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Network neighborhood for query Sequence : OBSCN_HUMAN

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OBSCN_HUMAN
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

OBSCN_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1931	Shared Neighborhood Hits	1931
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

TITIN_HUMAN
θ value	0 (rank : 2)	NC score	0.903999 (rank : 7)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2923	Shared Neighborhood Hits	1346
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

OBSL1_HUMAN
θ value	7.47326e-180 (rank : 3)	NC score	0.473598 (rank : 818)
Query Neighborhood Hits	1931	Target Neighborhood Hits	354	Shared Neighborhood Hits	319
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

HMCN1_HUMAN
θ value	6.80647e-157 (rank : 4)	NC score	0.329367 (rank : 947)
Query Neighborhood Hits	1931	Target Neighborhood Hits	983	Shared Neighborhood Hits	436
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

SPEG_HUMAN
θ value	1.18001e-100 (rank : 5)	NC score	0.943865 (rank : 3)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1762	Shared Neighborhood Hits	1244
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPEG_MOUSE
θ value	5.85632e-100 (rank : 6)	NC score	0.941840 (rank : 5)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1282
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PGBM_HUMAN
θ value	5.91091e-68 (rank : 7)	NC score	0.323939 (rank : 955)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1113	Shared Neighborhood Hits	448
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

TRIO_HUMAN
θ value	1.15626e-55 (rank : 8)	NC score	0.883924 (rank : 8)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1580	Shared Neighborhood Hits	1117
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

MYLK_HUMAN
θ value	1.72781e-51 (rank : 9)	NC score	0.945789 (rank : 2)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1328	Shared Neighborhood Hits	1134
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

DUET_HUMAN
θ value	4.25575e-50 (rank : 10)	NC score	0.917372 (rank : 6)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1220	Shared Neighborhood Hits	1063
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

MYLK_MOUSE
θ value	4.25575e-50 (rank : 11)	NC score	0.943805 (rank : 4)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1489	Shared Neighborhood Hits	1195
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

DAPK3_MOUSE
θ value	3.37202e-47 (rank : 12)	NC score	0.861366 (rank : 10)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	821
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KCC1B_HUMAN
θ value	2.41655e-45 (rank : 13)	NC score	0.856786 (rank : 17)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	832
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

DAPK2_MOUSE
θ value	9.18288e-45 (rank : 14)	NC score	0.861424 (rank : 9)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	824
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_HUMAN
θ value	1.01529e-43 (rank : 15)	NC score	0.860786 (rank : 12)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	820
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MYLK2_HUMAN
θ value	1.73182e-43 (rank : 16)	NC score	0.858165 (rank : 16)
Query Neighborhood Hits	1931	Target Neighborhood Hits	920	Shared Neighborhood Hits	853
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

KCC1B_MOUSE
θ value	2.26182e-43 (rank : 17)	NC score	0.856636 (rank : 18)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	832
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

DAPK3_HUMAN
θ value	4.2656e-42 (rank : 18)	NC score	0.859851 (rank : 14)
Query Neighborhood Hits	1931	Target Neighborhood Hits	945	Shared Neighborhood Hits	831
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ST17A_HUMAN
θ value	1.62093e-41 (rank : 19)	NC score	0.861167 (rank : 11)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	817
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_MOUSE
θ value	2.76489e-41 (rank : 20)	NC score	0.860027 (rank : 13)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KCC1D_MOUSE
θ value	6.15952e-41 (rank : 21)	NC score	0.855728 (rank : 26)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	831
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
θ value	8.04462e-41 (rank : 22)	NC score	0.855625 (rank : 27)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	830
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KPSH1_HUMAN
θ value	1.79215e-40 (rank : 23)	NC score	0.856337 (rank : 19)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	828
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

ST17B_HUMAN
θ value	3.99248e-40 (rank : 24)	NC score	0.859832 (rank : 15)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	824
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KCC1A_HUMAN
θ value	1.16164e-39 (rank : 25)	NC score	0.855974 (rank : 23)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	833
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	1.16164e-39 (rank : 26)	NC score	0.856117 (rank : 22)
Query Neighborhood Hits	1931	Target Neighborhood Hits	845	Shared Neighborhood Hits	833
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KPSH1_MOUSE
θ value	2.58786e-39 (rank : 27)	NC score	0.856313 (rank : 20)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	829
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

DAPK1_HUMAN
θ value	7.52953e-39 (rank : 28)	NC score	0.776191 (rank : 467)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1130	Shared Neighborhood Hits	842
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	1.28434e-38 (rank : 29)	NC score	0.772167 (rank : 480)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1138	Shared Neighborhood Hits	845
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

KPSH2_HUMAN
θ value	9.20422e-37 (rank : 30)	NC score	0.855893 (rank : 24)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	814
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KCC1G_HUMAN
θ value	1.20211e-36 (rank : 31)	NC score	0.853640 (rank : 31)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	833
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

MYPC3_HUMAN
θ value	1.20211e-36 (rank : 32)	NC score	0.381156 (rank : 905)
Query Neighborhood Hits	1931	Target Neighborhood Hits	318	Shared Neighborhood Hits	282
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

KCC1G_MOUSE
θ value	5.96599e-36 (rank : 33)	NC score	0.853736 (rank : 30)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	836
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC4_MOUSE
θ value	7.79185e-36 (rank : 34)	NC score	0.855877 (rank : 25)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	830
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_HUMAN
θ value	2.96089e-35 (rank : 35)	NC score	0.856275 (rank : 21)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	824
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KS6A2_MOUSE
θ value	6.59618e-35 (rank : 36)	NC score	0.840327 (rank : 119)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

MYPC3_MOUSE
θ value	8.61488e-35 (rank : 37)	NC score	0.381906 (rank : 904)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	276
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

KS6A2_HUMAN
θ value	1.24399e-33 (rank : 38)	NC score	0.839595 (rank : 129)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	841
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

ROBO2_HUMAN
θ value	1.6247e-33 (rank : 39)	NC score	0.431982 (rank : 837)
Query Neighborhood Hits	1931	Target Neighborhood Hits	479	Shared Neighborhood Hits	380
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

KS6A1_MOUSE
θ value	2.12192e-33 (rank : 40)	NC score	0.838990 (rank : 137)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	838
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

ROBO1_HUMAN
θ value	2.77131e-33 (rank : 41)	NC score	0.433626 (rank : 832)
Query Neighborhood Hits	1931	Target Neighborhood Hits	529	Shared Neighborhood Hits	392
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

STK36_HUMAN
θ value	3.61944e-33 (rank : 42)	NC score	0.845484 (rank : 78)
Query Neighborhood Hits	1931	Target Neighborhood Hits	896	Shared Neighborhood Hits	842
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

KS6A1_HUMAN
θ value	4.72714e-33 (rank : 43)	NC score	0.838694 (rank : 141)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	842
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

ROBO1_MOUSE
θ value	4.72714e-33 (rank : 44)	NC score	0.433438 (rank : 833)
Query Neighborhood Hits	1931	Target Neighborhood Hits	559	Shared Neighborhood Hits	403
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO2_MOUSE
θ value	1.0531e-32 (rank : 45)	NC score	0.431998 (rank : 836)
Query Neighborhood Hits	1931	Target Neighborhood Hits	504	Shared Neighborhood Hits	393
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

KS6A3_HUMAN
θ value	5.22648e-32 (rank : 46)	NC score	0.838750 (rank : 140)
Query Neighborhood Hits	1931	Target Neighborhood Hits	859	Shared Neighborhood Hits	842
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	5.22648e-32 (rank : 47)	NC score	0.838752 (rank : 139)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	842
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A6_HUMAN
θ value	1.98606e-31 (rank : 48)	NC score	0.839126 (rank : 135)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	840
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

PHKG1_HUMAN
θ value	3.3877e-31 (rank : 49)	NC score	0.848680 (rank : 53)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	831
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

ULK3_MOUSE
θ value	4.42448e-31 (rank : 50)	NC score	0.851938 (rank : 32)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	835
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

KCC2G_HUMAN
θ value	5.77852e-31 (rank : 51)	NC score	0.851935 (rank : 33)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	825
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	5.77852e-31 (rank : 52)	NC score	0.851934 (rank : 34)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	825
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2D_HUMAN
θ value	2.19584e-30 (rank : 53)	NC score	0.850920 (rank : 37)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	818
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

SN1L1_MOUSE
θ value	2.19584e-30 (rank : 54)	NC score	0.843066 (rank : 93)
Query Neighborhood Hits	1931	Target Neighborhood Hits	895	Shared Neighborhood Hits	845
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_MOUSE
θ value	2.86786e-30 (rank : 55)	NC score	0.841456 (rank : 108)
Query Neighborhood Hits	1931	Target Neighborhood Hits	944	Shared Neighborhood Hits	868
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

PGBM_MOUSE
θ value	3.74554e-30 (rank : 56)	NC score	0.309819 (rank : 966)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1073	Shared Neighborhood Hits	430
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

KCC2A_HUMAN
θ value	6.38894e-30 (rank : 57)	NC score	0.850805 (rank : 38)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	818
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

DCAK3_MOUSE
θ value	1.08979e-29 (rank : 58)	NC score	0.854831 (rank : 29)
Query Neighborhood Hits	1931	Target Neighborhood Hits	922	Shared Neighborhood Hits	839
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

MYPC1_HUMAN
θ value	1.08979e-29 (rank : 59)	NC score	0.393747 (rank : 892)
Query Neighborhood Hits	1931	Target Neighborhood Hits	303	Shared Neighborhood Hits	271
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

SN1L1_HUMAN
θ value	1.08979e-29 (rank : 60)	NC score	0.843261 (rank : 90)
Query Neighborhood Hits	1931	Target Neighborhood Hits	911	Shared Neighborhood Hits	853
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

STK36_MOUSE
θ value	1.08979e-29 (rank : 61)	NC score	0.842890 (rank : 94)
Query Neighborhood Hits	1931	Target Neighborhood Hits	877	Shared Neighborhood Hits	841
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

PLK4_MOUSE
θ value	1.4233e-29 (rank : 62)	NC score	0.849201 (rank : 47)
Query Neighborhood Hits	1931	Target Neighborhood Hits	879	Shared Neighborhood Hits	840
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

SN1L2_HUMAN
θ value	1.4233e-29 (rank : 63)	NC score	0.841316 (rank : 109)
Query Neighborhood Hits	1931	Target Neighborhood Hits	964	Shared Neighborhood Hits	876
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

MARK1_HUMAN
θ value	1.85889e-29 (rank : 64)	NC score	0.840091 (rank : 124)
Query Neighborhood Hits	1931	Target Neighborhood Hits	887	Shared Neighborhood Hits	844
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

CSKP_MOUSE
θ value	2.42779e-29 (rank : 65)	NC score	0.806732 (rank : 334)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1027	Shared Neighborhood Hits	834
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

KS6B2_MOUSE
θ value	5.40856e-29 (rank : 66)	NC score	0.831512 (rank : 176)
Query Neighborhood Hits	1931	Target Neighborhood Hits	871	Shared Neighborhood Hits	840
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PHKG1_MOUSE
θ value	5.40856e-29 (rank : 67)	NC score	0.848863 (rank : 51)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

CSKP_HUMAN
θ value	7.06379e-29 (rank : 68)	NC score	0.804450 (rank : 345)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1022	Shared Neighborhood Hits	831
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

KCC2A_MOUSE
θ value	7.06379e-29 (rank : 69)	NC score	0.850266 (rank : 40)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	816
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KS6B2_HUMAN
θ value	7.06379e-29 (rank : 70)	NC score	0.832958 (rank : 164)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	845
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

MARK4_HUMAN
θ value	9.2256e-29 (rank : 71)	NC score	0.842263 (rank : 103)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	852
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

DCAK1_HUMAN
θ value	1.2049e-28 (rank : 72)	NC score	0.842324 (rank : 102)
Query Neighborhood Hits	1931	Target Neighborhood Hits	877	Shared Neighborhood Hits	833
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	1.2049e-28 (rank : 73)	NC score	0.842630 (rank : 99)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	830
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

K0999_HUMAN
θ value	1.2049e-28 (rank : 74)	NC score	0.842691 (rank : 97)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	839
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

HUNK_MOUSE
θ value	1.57365e-28 (rank : 75)	NC score	0.847974 (rank : 56)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	842
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

K0999_MOUSE
θ value	1.57365e-28 (rank : 76)	NC score	0.842857 (rank : 95)
Query Neighborhood Hits	1931	Target Neighborhood Hits	931	Shared Neighborhood Hits	853
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MARK4_MOUSE
θ value	2.68423e-28 (rank : 77)	NC score	0.842211 (rank : 104)
Query Neighborhood Hits	1931	Target Neighborhood Hits	898	Shared Neighborhood Hits	852
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MYPC2_HUMAN
θ value	2.68423e-28 (rank : 78)	NC score	0.385679 (rank : 901)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	279
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

HUNK_HUMAN
θ value	4.57862e-28 (rank : 79)	NC score	0.847576 (rank : 59)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	844
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

DCAK2_HUMAN
θ value	5.97985e-28 (rank : 80)	NC score	0.841950 (rank : 106)
Query Neighborhood Hits	1931	Target Neighborhood Hits	862	Shared Neighborhood Hits	828
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK3_HUMAN
θ value	5.97985e-28 (rank : 81)	NC score	0.855314 (rank : 28)
Query Neighborhood Hits	1931	Target Neighborhood Hits	888	Shared Neighborhood Hits	834
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

PLK4_HUMAN
θ value	5.97985e-28 (rank : 82)	NC score	0.849171 (rank : 48)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	841
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

BRSK1_HUMAN
θ value	7.80994e-28 (rank : 83)	NC score	0.847743 (rank : 58)
Query Neighborhood Hits	1931	Target Neighborhood Hits	942	Shared Neighborhood Hits	865
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

PHKG2_HUMAN
θ value	7.80994e-28 (rank : 84)	NC score	0.849681 (rank : 44)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	830
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

DCAK2_MOUSE
θ value	1.33217e-27 (rank : 85)	NC score	0.842393 (rank : 101)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	829
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

SLK_HUMAN
θ value	1.33217e-27 (rank : 86)	NC score	0.793453 (rank : 395)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1775	Shared Neighborhood Hits	890
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

SLK_MOUSE
θ value	1.73987e-27 (rank : 87)	NC score	0.794408 (rank : 390)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1798	Shared Neighborhood Hits	893
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

MARK1_MOUSE
θ value	2.27234e-27 (rank : 88)	NC score	0.839837 (rank : 127)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	844
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	2.27234e-27 (rank : 89)	NC score	0.840621 (rank : 115)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1056	Shared Neighborhood Hits	893
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MAPK3_HUMAN
θ value	2.96777e-27 (rank : 90)	NC score	0.843291 (rank : 89)
Query Neighborhood Hits	1931	Target Neighborhood Hits	807	Shared Neighborhood Hits	795
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

NEK3_HUMAN
θ value	2.96777e-27 (rank : 91)	NC score	0.839374 (rank : 133)
Query Neighborhood Hits	1931	Target Neighborhood Hits	865	Shared Neighborhood Hits	839
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

ROBO3_HUMAN
θ value	2.96777e-27 (rank : 92)	NC score	0.434910 (rank : 830)
Query Neighborhood Hits	1931	Target Neighborhood Hits	570	Shared Neighborhood Hits	428
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

KCC2B_HUMAN
θ value	3.87602e-27 (rank : 93)	NC score	0.849628 (rank : 46)
Query Neighborhood Hits	1931	Target Neighborhood Hits	866	Shared Neighborhood Hits	830
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	3.87602e-27 (rank : 94)	NC score	0.847974 (rank : 57)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	818
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KS6B1_HUMAN
θ value	3.87602e-27 (rank : 95)	NC score	0.832690 (rank : 166)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	834
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	3.87602e-27 (rank : 96)	NC score	0.832542 (rank : 169)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	833
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

MARK2_MOUSE
θ value	5.06226e-27 (rank : 97)	NC score	0.839921 (rank : 126)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1018	Shared Neighborhood Hits	880
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

PLK2_HUMAN
θ value	5.06226e-27 (rank : 98)	NC score	0.844494 (rank : 80)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	836
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	5.06226e-27 (rank : 99)	NC score	0.844148 (rank : 83)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	836
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MYPC2_MOUSE
θ value	6.61148e-27 (rank : 100)	NC score	0.381072 (rank : 906)
Query Neighborhood Hits	1931	Target Neighborhood Hits	297	Shared Neighborhood Hits	264
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MAPK3_MOUSE
θ value	8.63488e-27 (rank : 101)	NC score	0.843905 (rank : 84)
Query Neighborhood Hits	1931	Target Neighborhood Hits	811	Shared Neighborhood Hits	805
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

NIM1_MOUSE
θ value	8.63488e-27 (rank : 102)	NC score	0.846728 (rank : 63)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	837
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

SNRK_HUMAN
θ value	8.63488e-27 (rank : 103)	NC score	0.848660 (rank : 54)
Query Neighborhood Hits	1931	Target Neighborhood Hits	855	Shared Neighborhood Hits	821
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

MAST3_HUMAN
θ value	1.12775e-26 (rank : 104)	NC score	0.823505 (rank : 225)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1128	Shared Neighborhood Hits	896
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MCF2L_MOUSE
θ value	1.12775e-26 (rank : 105)	NC score	0.157982 (rank : 1070)
Query Neighborhood Hits	1931	Target Neighborhood Hits	255	Shared Neighborhood Hits	82
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

PHKG2_MOUSE
θ value	1.12775e-26 (rank : 106)	NC score	0.850096 (rank : 42)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	831
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

SDK1_MOUSE
θ value	1.12775e-26 (rank : 107)	NC score	0.405627 (rank : 874)
Query Neighborhood Hits	1931	Target Neighborhood Hits	495	Shared Neighborhood Hits	382
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SN_HUMAN
θ value	1.12775e-26 (rank : 108)	NC score	0.376772 (rank : 911)
Query Neighborhood Hits	1931	Target Neighborhood Hits	434	Shared Neighborhood Hits	339
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

HAPIP_HUMAN
θ value	1.47289e-26 (rank : 109)	NC score	0.149477 (rank : 1080)
Query Neighborhood Hits	1931	Target Neighborhood Hits	350	Shared Neighborhood Hits	86
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

MARK3_MOUSE
θ value	1.47289e-26 (rank : 110)	NC score	0.840488 (rank : 117)
Query Neighborhood Hits	1931	Target Neighborhood Hits	919	Shared Neighborhood Hits	852
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

AURKC_MOUSE
θ value	1.92365e-26 (rank : 111)	NC score	0.849931 (rank : 43)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	840
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

CHK2_MOUSE
θ value	1.92365e-26 (rank : 112)	NC score	0.851238 (rank : 36)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

STK6_HUMAN
θ value	1.92365e-26 (rank : 113)	NC score	0.849129 (rank : 50)
Query Neighborhood Hits	1931	Target Neighborhood Hits	916	Shared Neighborhood Hits	860
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

BRSK2_HUMAN
θ value	2.51237e-26 (rank : 114)	NC score	0.846942 (rank : 62)
Query Neighborhood Hits	1931	Target Neighborhood Hits	897	Shared Neighborhood Hits	847
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

MCF2_HUMAN
θ value	2.51237e-26 (rank : 115)	NC score	0.160997 (rank : 1066)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

AURKC_HUMAN
θ value	3.28125e-26 (rank : 116)	NC score	0.849629 (rank : 45)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	842
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

MKNK2_HUMAN
θ value	3.28125e-26 (rank : 117)	NC score	0.840295 (rank : 120)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	813
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

STK33_HUMAN
θ value	7.30988e-26 (rank : 118)	NC score	0.851807 (rank : 35)
Query Neighborhood Hits	1931	Target Neighborhood Hits	879	Shared Neighborhood Hits	838
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

MAST2_MOUSE
θ value	9.54697e-26 (rank : 119)	NC score	0.821124 (rank : 247)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1110	Shared Neighborhood Hits	884
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST1_MOUSE
θ value	1.24688e-25 (rank : 120)	NC score	0.818289 (rank : 274)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1123	Shared Neighborhood Hits	900
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

NIM1_HUMAN
θ value	1.24688e-25 (rank : 121)	NC score	0.845319 (rank : 79)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KPCD2_HUMAN
θ value	1.62847e-25 (rank : 122)	NC score	0.843134 (rank : 92)
Query Neighborhood Hits	1931	Target Neighborhood Hits	910	Shared Neighborhood Hits	843
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

MKNK2_MOUSE
θ value	1.62847e-25 (rank : 123)	NC score	0.839441 (rank : 132)
Query Neighborhood Hits	1931	Target Neighborhood Hits	819	Shared Neighborhood Hits	811
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

ST38L_HUMAN
θ value	2.12685e-25 (rank : 124)	NC score	0.812375 (rank : 313)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	794
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

AKT3_HUMAN
θ value	2.77775e-25 (rank : 125)	NC score	0.829854 (rank : 187)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	2.77775e-25 (rank : 126)	NC score	0.829846 (rank : 188)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	834
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

MAST2_HUMAN
θ value	2.77775e-25 (rank : 127)	NC score	0.819775 (rank : 256)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1189	Shared Neighborhood Hits	910
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

NCAM2_MOUSE
θ value	2.77775e-25 (rank : 128)	NC score	0.434466 (rank : 831)
Query Neighborhood Hits	1931	Target Neighborhood Hits	472	Shared Neighborhood Hits	398
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

PLK3_MOUSE
θ value	3.62785e-25 (rank : 129)	NC score	0.845636 (rank : 74)
Query Neighborhood Hits	1931	Target Neighborhood Hits	863	Shared Neighborhood Hits	842
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

SDK1_HUMAN
θ value	3.62785e-25 (rank : 130)	NC score	0.407821 (rank : 868)
Query Neighborhood Hits	1931	Target Neighborhood Hits	511	Shared Neighborhood Hits	390
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

STK10_HUMAN
θ value	3.62785e-25 (rank : 131)	NC score	0.776901 (rank : 465)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1921	Shared Neighborhood Hits	932
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

NEK3_MOUSE
θ value	4.73814e-25 (rank : 132)	NC score	0.840533 (rank : 116)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	840
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

SNRK_MOUSE
θ value	4.73814e-25 (rank : 133)	NC score	0.847453 (rank : 60)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	822
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

KAPCB_HUMAN
θ value	6.18819e-25 (rank : 134)	NC score	0.833712 (rank : 158)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	831
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_MOUSE
θ value	6.18819e-25 (rank : 135)	NC score	0.833481 (rank : 161)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	831
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

MAST1_HUMAN
θ value	6.18819e-25 (rank : 136)	NC score	0.818326 (rank : 273)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1146	Shared Neighborhood Hits	907
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MYPN_HUMAN
θ value	6.18819e-25 (rank : 137)	NC score	0.423325 (rank : 843)
Query Neighborhood Hits	1931	Target Neighborhood Hits	418	Shared Neighborhood Hits	320
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

PLK3_HUMAN
θ value	8.08199e-25 (rank : 138)	NC score	0.845616 (rank : 75)
Query Neighborhood Hits	1931	Target Neighborhood Hits	865	Shared Neighborhood Hits	843
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PTK7_HUMAN
θ value	8.08199e-25 (rank : 139)	NC score	0.769924 (rank : 489)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1103	Shared Neighborhood Hits	1057
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

ST38L_MOUSE
θ value	8.08199e-25 (rank : 140)	NC score	0.806652 (rank : 335)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	788
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

MAST4_HUMAN
θ value	1.37858e-24 (rank : 141)	NC score	0.813609 (rank : 305)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1804	Shared Neighborhood Hits	1063
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

CNTN5_HUMAN
θ value	1.80048e-24 (rank : 142)	NC score	0.409519 (rank : 867)
Query Neighborhood Hits	1931	Target Neighborhood Hits	446	Shared Neighborhood Hits	383
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

KPCD1_HUMAN
θ value	1.80048e-24 (rank : 143)	NC score	0.842424 (rank : 100)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	840
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD1_MOUSE
θ value	1.80048e-24 (rank : 144)	NC score	0.842149 (rank : 105)
Query Neighborhood Hits	1931	Target Neighborhood Hits	891	Shared Neighborhood Hits	841
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

ROBO3_MOUSE
θ value	1.80048e-24 (rank : 145)	NC score	0.430403 (rank : 838)
Query Neighborhood Hits	1931	Target Neighborhood Hits	524	Shared Neighborhood Hits	408
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

DSCL1_HUMAN
θ value	2.35151e-24 (rank : 146)	NC score	0.428303 (rank : 840)
Query Neighborhood Hits	1931	Target Neighborhood Hits	589	Shared Neighborhood Hits	449
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

KS6A4_MOUSE
θ value	2.35151e-24 (rank : 147)	NC score	0.832412 (rank : 171)
Query Neighborhood Hits	1931	Target Neighborhood Hits	866	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

MELK_HUMAN
θ value	2.35151e-24 (rank : 148)	NC score	0.845583 (rank : 76)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	834
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MYPN_MOUSE
θ value	2.35151e-24 (rank : 149)	NC score	0.420469 (rank : 848)
Query Neighborhood Hits	1931	Target Neighborhood Hits	421	Shared Neighborhood Hits	319
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

STK38_HUMAN
θ value	2.35151e-24 (rank : 150)	NC score	0.811645 (rank : 319)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	802
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK6_MOUSE
θ value	2.35151e-24 (rank : 151)	NC score	0.849166 (rank : 49)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	853
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

KS6A4_HUMAN
θ value	3.07116e-24 (rank : 152)	NC score	0.832276 (rank : 172)
Query Neighborhood Hits	1931	Target Neighborhood Hits	868	Shared Neighborhood Hits	842
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

AAPK2_HUMAN
θ value	5.23862e-24 (rank : 153)	NC score	0.842644 (rank : 98)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	832
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

NUAK2_HUMAN
θ value	5.23862e-24 (rank : 154)	NC score	0.846945 (rank : 61)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	844
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

SN_MOUSE
θ value	5.23862e-24 (rank : 155)	NC score	0.378951 (rank : 908)
Query Neighborhood Hits	1931	Target Neighborhood Hits	416	Shared Neighborhood Hits	320
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

AURKB_MOUSE
θ value	6.84181e-24 (rank : 156)	NC score	0.848710 (rank : 52)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

KGP2_HUMAN
θ value	6.84181e-24 (rank : 157)	NC score	0.824301 (rank : 220)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1023	Shared Neighborhood Hits	845
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

ULK3_HUMAN
θ value	6.84181e-24 (rank : 158)	NC score	0.850259 (rank : 41)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

NUAK2_MOUSE
θ value	8.93572e-24 (rank : 159)	NC score	0.846387 (rank : 64)
Query Neighborhood Hits	1931	Target Neighborhood Hits	878	Shared Neighborhood Hits	846
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

TSSK4_MOUSE
θ value	8.93572e-24 (rank : 160)	NC score	0.842700 (rank : 96)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

CAMKV_HUMAN
θ value	1.5242e-23 (rank : 161)	NC score	0.830729 (rank : 182)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1084	Shared Neighborhood Hits	866
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	1.5242e-23 (rank : 162)	NC score	0.833806 (rank : 157)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	797
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MAPK2_MOUSE
θ value	1.5242e-23 (rank : 163)	NC score	0.845512 (rank : 77)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	814
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

KGP2_MOUSE
θ value	1.99067e-23 (rank : 164)	NC score	0.823985 (rank : 221)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1029	Shared Neighborhood Hits	841
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

MELK_MOUSE
θ value	1.99067e-23 (rank : 165)	NC score	0.845642 (rank : 73)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	833
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

ROCK2_HUMAN
θ value	1.99067e-23 (rank : 166)	NC score	0.725889 (rank : 565)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2073	Shared Neighborhood Hits	894
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

STK38_MOUSE
θ value	1.99067e-23 (rank : 167)	NC score	0.811226 (rank : 322)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	801
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

KPCD3_MOUSE
θ value	2.59989e-23 (rank : 168)	NC score	0.840449 (rank : 118)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	838
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

MAPK2_HUMAN
θ value	3.39556e-23 (rank : 169)	NC score	0.845931 (rank : 68)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	818
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

NUAK1_HUMAN
θ value	3.39556e-23 (rank : 170)	NC score	0.846082 (rank : 65)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	842
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

KAPCA_MOUSE
θ value	4.43474e-23 (rank : 171)	NC score	0.833919 (rank : 156)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	830
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

NCAM2_HUMAN
θ value	4.43474e-23 (rank : 172)	NC score	0.432358 (rank : 835)
Query Neighborhood Hits	1931	Target Neighborhood Hits	441	Shared Neighborhood Hits	387
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

KKCC2_HUMAN
θ value	5.79196e-23 (rank : 173)	NC score	0.845808 (rank : 72)
Query Neighborhood Hits	1931	Target Neighborhood Hits	852	Shared Neighborhood Hits	831
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	5.79196e-23 (rank : 174)	NC score	0.845877 (rank : 69)
Query Neighborhood Hits	1931	Target Neighborhood Hits	855	Shared Neighborhood Hits	832
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

NUAK1_MOUSE
θ value	5.79196e-23 (rank : 175)	NC score	0.846034 (rank : 67)
Query Neighborhood Hits	1931	Target Neighborhood Hits	881	Shared Neighborhood Hits	843
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

KAPCA_HUMAN
θ value	7.56453e-23 (rank : 176)	NC score	0.834078 (rank : 154)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	832
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KPCD3_HUMAN
θ value	7.56453e-23 (rank : 177)	NC score	0.840209 (rank : 122)
Query Neighborhood Hits	1931	Target Neighborhood Hits	895	Shared Neighborhood Hits	838
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KS6A5_HUMAN
θ value	7.56453e-23 (rank : 178)	NC score	0.834604 (rank : 151)
Query Neighborhood Hits	1931	Target Neighborhood Hits	855	Shared Neighborhood Hits	839
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

STK10_MOUSE
θ value	7.56453e-23 (rank : 179)	NC score	0.755133 (rank : 526)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2132	Shared Neighborhood Hits	927
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

DSCAM_HUMAN
θ value	9.87957e-23 (rank : 180)	NC score	0.425762 (rank : 841)
Query Neighborhood Hits	1931	Target Neighborhood Hits	524	Shared Neighborhood Hits	404
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

NEK1_MOUSE
θ value	9.87957e-23 (rank : 181)	NC score	0.830734 (rank : 181)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1311	Shared Neighborhood Hits	882
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK8_HUMAN
θ value	9.87957e-23 (rank : 182)	NC score	0.824822 (rank : 218)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	836
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	9.87957e-23 (rank : 183)	NC score	0.824948 (rank : 217)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	836
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

KAPCG_HUMAN
θ value	1.29031e-22 (rank : 184)	NC score	0.836835 (rank : 143)
Query Neighborhood Hits	1931	Target Neighborhood Hits	845	Shared Neighborhood Hits	834
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

PKN3_HUMAN
θ value	1.6852e-22 (rank : 185)	NC score	0.820770 (rank : 251)
Query Neighborhood Hits	1931	Target Neighborhood Hits	893	Shared Neighborhood Hits	839
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

ROCK2_MOUSE
θ value	1.6852e-22 (rank : 186)	NC score	0.719632 (rank : 573)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2072	Shared Neighborhood Hits	892
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

TSSK3_HUMAN
θ value	1.6852e-22 (rank : 187)	NC score	0.839471 (rank : 131)
Query Neighborhood Hits	1931	Target Neighborhood Hits	806	Shared Neighborhood Hits	803
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

AKT2_HUMAN
θ value	2.20094e-22 (rank : 188)	NC score	0.828566 (rank : 198)
Query Neighborhood Hits	1931	Target Neighborhood Hits	878	Shared Neighborhood Hits	829
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

NEK11_MOUSE
θ value	2.20094e-22 (rank : 189)	NC score	0.829349 (rank : 189)
Query Neighborhood Hits	1931	Target Neighborhood Hits	875	Shared Neighborhood Hits	836
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

STK3_MOUSE
θ value	2.20094e-22 (rank : 190)	NC score	0.822209 (rank : 236)
Query Neighborhood Hits	1931	Target Neighborhood Hits	869	Shared Neighborhood Hits	835
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

YSK4_HUMAN
θ value	2.20094e-22 (rank : 191)	NC score	0.823672 (rank : 223)
Query Neighborhood Hits	1931	Target Neighborhood Hits	921	Shared Neighborhood Hits	841
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

KKCC1_HUMAN
θ value	2.87452e-22 (rank : 192)	NC score	0.844191 (rank : 82)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	837
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

ULK1_HUMAN
θ value	2.87452e-22 (rank : 193)	NC score	0.843467 (rank : 86)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1121	Shared Neighborhood Hits	938
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

MKNK1_MOUSE
θ value	3.75424e-22 (rank : 194)	NC score	0.835545 (rank : 147)
Query Neighborhood Hits	1931	Target Neighborhood Hits	811	Shared Neighborhood Hits	800
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

NRCAM_HUMAN
θ value	3.75424e-22 (rank : 195)	NC score	0.401867 (rank : 882)
Query Neighborhood Hits	1931	Target Neighborhood Hits	439	Shared Neighborhood Hits	368
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

ULK1_MOUSE
θ value	3.75424e-22 (rank : 196)	NC score	0.841753 (rank : 107)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1214	Shared Neighborhood Hits	977
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

MARK3_HUMAN
θ value	4.9032e-22 (rank : 197)	NC score	0.836342 (rank : 145)
Query Neighborhood Hits	1931	Target Neighborhood Hits	893	Shared Neighborhood Hits	841
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

PKHG4_HUMAN
θ value	4.9032e-22 (rank : 198)	NC score	0.165796 (rank : 1057)
Query Neighborhood Hits	1931	Target Neighborhood Hits	200	Shared Neighborhood Hits	109
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

TSSK3_MOUSE
θ value	4.9032e-22 (rank : 199)	NC score	0.839034 (rank : 136)
Query Neighborhood Hits	1931	Target Neighborhood Hits	806	Shared Neighborhood Hits	802
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

AKT2_MOUSE
θ value	8.36355e-22 (rank : 200)	NC score	0.827927 (rank : 204)
Query Neighborhood Hits	1931	Target Neighborhood Hits	875	Shared Neighborhood Hits	829
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

KKCC1_MOUSE
θ value	8.36355e-22 (rank : 201)	NC score	0.844451 (rank : 81)
Query Neighborhood Hits	1931	Target Neighborhood Hits	866	Shared Neighborhood Hits	838
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KPCE_HUMAN
θ value	8.36355e-22 (rank : 202)	NC score	0.814813 (rank : 296)
Query Neighborhood Hits	1931	Target Neighborhood Hits	906	Shared Neighborhood Hits	833
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

PRKX_HUMAN
θ value	8.36355e-22 (rank : 203)	NC score	0.834777 (rank : 150)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	835
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

STK4_MOUSE
θ value	8.36355e-22 (rank : 204)	NC score	0.821541 (rank : 242)
Query Neighborhood Hits	1931	Target Neighborhood Hits	873	Shared Neighborhood Hits	835
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

KPCL_MOUSE
θ value	1.09232e-21 (rank : 205)	NC score	0.816538 (rank : 281)
Query Neighborhood Hits	1931	Target Neighborhood Hits	891	Shared Neighborhood Hits	828
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

ROCK1_HUMAN
θ value	1.42661e-21 (rank : 206)	NC score	0.721758 (rank : 568)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2000	Shared Neighborhood Hits	886
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	1.42661e-21 (rank : 207)	NC score	0.707046 (rank : 594)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2126	Shared Neighborhood Hits	899
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

TSSK6_MOUSE
θ value	1.42661e-21 (rank : 208)	NC score	0.841127 (rank : 111)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	821
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PTPRF_HUMAN
θ value	1.86321e-21 (rank : 209)	NC score	0.300481 (rank : 978)
Query Neighborhood Hits	1931	Target Neighborhood Hits	489	Shared Neighborhood Hits	355
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

STK4_HUMAN
θ value	1.86321e-21 (rank : 210)	NC score	0.821502 (rank : 243)
Query Neighborhood Hits	1931	Target Neighborhood Hits	870	Shared Neighborhood Hits	835
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

KPCE_MOUSE
θ value	2.43343e-21 (rank : 211)	NC score	0.814899 (rank : 294)
Query Neighborhood Hits	1931	Target Neighborhood Hits	906	Shared Neighborhood Hits	834
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MUSK_HUMAN
θ value	2.43343e-21 (rank : 212)	NC score	0.736311 (rank : 553)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1074	Shared Neighborhood Hits	1046
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	2.43343e-21 (rank : 213)	NC score	0.732970 (rank : 562)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1057	Shared Neighborhood Hits	1035
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

STK3_HUMAN
θ value	2.43343e-21 (rank : 214)	NC score	0.821930 (rank : 241)
Query Neighborhood Hits	1931	Target Neighborhood Hits	861	Shared Neighborhood Hits	838
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

CNTN5_MOUSE
θ value	3.17815e-21 (rank : 215)	NC score	0.405567 (rank : 875)
Query Neighborhood Hits	1931	Target Neighborhood Hits	434	Shared Neighborhood Hits	374
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

M3K13_HUMAN
θ value	3.17815e-21 (rank : 216)	NC score	0.782096 (rank : 449)
Query Neighborhood Hits	1931	Target Neighborhood Hits	911	Shared Neighborhood Hits	845
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

NFASC_HUMAN
θ value	3.17815e-21 (rank : 217)	NC score	0.410466 (rank : 865)
Query Neighborhood Hits	1931	Target Neighborhood Hits	497	Shared Neighborhood Hits	394
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

PRKX_MOUSE
θ value	3.17815e-21 (rank : 218)	NC score	0.834527 (rank : 152)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	838
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

TSSK4_HUMAN
θ value	3.17815e-21 (rank : 219)	NC score	0.840045 (rank : 125)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	830
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

AURKB_HUMAN
θ value	4.15078e-21 (rank : 220)	NC score	0.848547 (rank : 55)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	840
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

NFASC_MOUSE
θ value	4.15078e-21 (rank : 221)	NC score	0.412873 (rank : 859)
Query Neighborhood Hits	1931	Target Neighborhood Hits	475	Shared Neighborhood Hits	388
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

SDK2_MOUSE
θ value	4.15078e-21 (rank : 222)	NC score	0.401732 (rank : 884)
Query Neighborhood Hits	1931	Target Neighborhood Hits	480	Shared Neighborhood Hits	378
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

TSSK6_HUMAN
θ value	4.15078e-21 (rank : 223)	NC score	0.840261 (rank : 121)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	820
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

ULK2_HUMAN
θ value	4.15078e-21 (rank : 224)	NC score	0.843306 (rank : 88)
Query Neighborhood Hits	1931	Target Neighborhood Hits	979	Shared Neighborhood Hits	878
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

AAPK1_HUMAN
θ value	5.42112e-21 (rank : 225)	NC score	0.843312 (rank : 87)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	832
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	5.42112e-21 (rank : 226)	NC score	0.843145 (rank : 91)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	832
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

M4K2_HUMAN
θ value	5.42112e-21 (rank : 227)	NC score	0.812104 (rank : 318)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	831
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	5.42112e-21 (rank : 228)	NC score	0.812434 (rank : 312)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

CHK2_HUMAN
θ value	9.24701e-21 (rank : 229)	NC score	0.850562 (rank : 39)
Query Neighborhood Hits	1931	Target Neighborhood Hits	859	Shared Neighborhood Hits	827
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

DCC_MOUSE
θ value	9.24701e-21 (rank : 230)	NC score	0.411427 (rank : 862)
Query Neighborhood Hits	1931	Target Neighborhood Hits	896	Shared Neighborhood Hits	544
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

ULK2_MOUSE
θ value	9.24701e-21 (rank : 231)	NC score	0.843746 (rank : 85)
Query Neighborhood Hits	1931	Target Neighborhood Hits	943	Shared Neighborhood Hits	869
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

CDKL4_MOUSE
θ value	1.2077e-20 (rank : 232)	NC score	0.815467 (rank : 289)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KPCA_MOUSE
θ value	1.2077e-20 (rank : 233)	NC score	0.799455 (rank : 363)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1067	Shared Neighborhood Hits	847
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

M4K3_HUMAN
θ value	1.2077e-20 (rank : 234)	NC score	0.813627 (rank : 304)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

PTPRD_MOUSE
θ value	1.2077e-20 (rank : 235)	NC score	0.299342 (rank : 980)
Query Neighborhood Hits	1931	Target Neighborhood Hits	491	Shared Neighborhood Hits	349
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

CDKL4_HUMAN
θ value	1.5773e-20 (rank : 236)	NC score	0.812755 (rank : 310)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	820
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KPCA_HUMAN
θ value	1.5773e-20 (rank : 237)	NC score	0.798571 (rank : 366)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1070	Shared Neighborhood Hits	851
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

NEK1_HUMAN
θ value	1.5773e-20 (rank : 238)	NC score	0.832469 (rank : 170)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1129	Shared Neighborhood Hits	854
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK7_MOUSE
θ value	1.5773e-20 (rank : 239)	NC score	0.829155 (rank : 193)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	842
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

OXSR1_HUMAN
θ value	1.5773e-20 (rank : 240)	NC score	0.820819 (rank : 250)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	843
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

AKT1_HUMAN
θ value	2.69047e-20 (rank : 241)	NC score	0.825500 (rank : 215)
Query Neighborhood Hits	1931	Target Neighborhood Hits	885	Shared Neighborhood Hits	830
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	2.69047e-20 (rank : 242)	NC score	0.825173 (rank : 216)
Query Neighborhood Hits	1931	Target Neighborhood Hits	878	Shared Neighborhood Hits	829
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

PLK1_HUMAN
θ value	2.69047e-20 (rank : 243)	NC score	0.845810 (rank : 71)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	831
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

STK24_HUMAN
θ value	2.69047e-20 (rank : 244)	NC score	0.819042 (rank : 266)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

CDK2_HUMAN
θ value	3.51386e-20 (rank : 245)	NC score	0.803015 (rank : 351)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDKL1_HUMAN
θ value	3.51386e-20 (rank : 246)	NC score	0.815582 (rank : 288)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	824
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

FGRL1_HUMAN
θ value	3.51386e-20 (rank : 247)	NC score	0.417877 (rank : 854)
Query Neighborhood Hits	1931	Target Neighborhood Hits	335	Shared Neighborhood Hits	297
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

NEK7_HUMAN
θ value	3.51386e-20 (rank : 248)	NC score	0.829048 (rank : 195)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	841
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

PAK2_HUMAN
θ value	3.51386e-20 (rank : 249)	NC score	0.833608 (rank : 159)
Query Neighborhood Hits	1931	Target Neighborhood Hits	862	Shared Neighborhood Hits	845
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	3.51386e-20 (rank : 250)	NC score	0.833604 (rank : 160)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PDPK1_MOUSE
θ value	3.51386e-20 (rank : 251)	NC score	0.840923 (rank : 112)
Query Neighborhood Hits	1931	Target Neighborhood Hits	852	Shared Neighborhood Hits	835
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

TAOK2_HUMAN
θ value	3.51386e-20 (rank : 252)	NC score	0.795086 (rank : 387)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1172	Shared Neighborhood Hits	861
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

CNTN4_HUMAN
θ value	4.58923e-20 (rank : 253)	NC score	0.407376 (rank : 872)
Query Neighborhood Hits	1931	Target Neighborhood Hits	449	Shared Neighborhood Hits	386
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

OXSR1_MOUSE
θ value	4.58923e-20 (rank : 254)	NC score	0.820545 (rank : 252)
Query Neighborhood Hits	1931	Target Neighborhood Hits	865	Shared Neighborhood Hits	840
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PDPK1_HUMAN
θ value	4.58923e-20 (rank : 255)	NC score	0.841209 (rank : 110)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	836
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

TAOK2_MOUSE
θ value	4.58923e-20 (rank : 256)	NC score	0.783271 (rank : 444)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1373	Shared Neighborhood Hits	882
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

KPCB_HUMAN
θ value	5.99374e-20 (rank : 257)	NC score	0.792616 (rank : 402)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1121	Shared Neighborhood Hits	854
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	5.99374e-20 (rank : 258)	NC score	0.792917 (rank : 399)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1117	Shared Neighborhood Hits	854
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KS6A5_MOUSE
θ value	5.99374e-20 (rank : 259)	NC score	0.828065 (rank : 202)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	837
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

NEK6_HUMAN
θ value	5.99374e-20 (rank : 260)	NC score	0.831825 (rank : 174)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	841
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

PTPRD_HUMAN
θ value	5.99374e-20 (rank : 261)	NC score	0.291832 (rank : 984)
Query Neighborhood Hits	1931	Target Neighborhood Hits	485	Shared Neighborhood Hits	342
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

STK24_MOUSE
θ value	5.99374e-20 (rank : 262)	NC score	0.818468 (rank : 272)
Query Neighborhood Hits	1931	Target Neighborhood Hits	856	Shared Neighborhood Hits	844
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

NCA11_HUMAN
θ value	7.82807e-20 (rank : 263)	NC score	0.422372 (rank : 844)
Query Neighborhood Hits	1931	Target Neighborhood Hits	443	Shared Neighborhood Hits	375
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA12_HUMAN
θ value	7.82807e-20 (rank : 264)	NC score	0.423594 (rank : 842)
Query Neighborhood Hits	1931	Target Neighborhood Hits	437	Shared Neighborhood Hits	372
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

KPCL_HUMAN
θ value	1.02238e-19 (rank : 265)	NC score	0.814862 (rank : 295)
Query Neighborhood Hits	1931	Target Neighborhood Hits	887	Shared Neighborhood Hits	828
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

NEK11_HUMAN
θ value	1.02238e-19 (rank : 266)	NC score	0.826442 (rank : 207)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1043	Shared Neighborhood Hits	857
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK6_MOUSE
θ value	1.02238e-19 (rank : 267)	NC score	0.831562 (rank : 175)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	841
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

PKN3_MOUSE
θ value	1.02238e-19 (rank : 268)	NC score	0.818916 (rank : 268)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	866
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PTPRS_HUMAN
θ value	1.02238e-19 (rank : 269)	NC score	0.290564 (rank : 986)
Query Neighborhood Hits	1931	Target Neighborhood Hits	472	Shared Neighborhood Hits	339
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

SDK2_HUMAN
θ value	1.02238e-19 (rank : 270)	NC score	0.403845 (rank : 876)
Query Neighborhood Hits	1931	Target Neighborhood Hits	495	Shared Neighborhood Hits	387
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CNTN4_MOUSE
θ value	1.33526e-19 (rank : 271)	NC score	0.407443 (rank : 871)
Query Neighborhood Hits	1931	Target Neighborhood Hits	445	Shared Neighborhood Hits	383
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

ERN2_HUMAN
θ value	1.33526e-19 (rank : 272)	NC score	0.792067 (rank : 405)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	820
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

NRCAM_MOUSE
θ value	1.33526e-19 (rank : 273)	NC score	0.402771 (rank : 878)
Query Neighborhood Hits	1931	Target Neighborhood Hits	432	Shared Neighborhood Hits	351
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

SGK2_MOUSE
θ value	1.33526e-19 (rank : 274)	NC score	0.828292 (rank : 201)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	827
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

DMPK_MOUSE
θ value	1.74391e-19 (rank : 275)	NC score	0.804981 (rank : 343)
Query Neighborhood Hits	1931	Target Neighborhood Hits	908	Shared Neighborhood Hits	824
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

SGK3_MOUSE
θ value	2.27762e-19 (rank : 276)	NC score	0.823174 (rank : 227)
Query Neighborhood Hits	1931	Target Neighborhood Hits	882	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

CNTN3_MOUSE
θ value	2.97466e-19 (rank : 277)	NC score	0.398576 (rank : 888)
Query Neighborhood Hits	1931	Target Neighborhood Hits	447	Shared Neighborhood Hits	374
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

LRIG2_MOUSE
θ value	2.97466e-19 (rank : 278)	NC score	0.301570 (rank : 976)
Query Neighborhood Hits	1931	Target Neighborhood Hits	586	Shared Neighborhood Hits	320
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

MST4_HUMAN
θ value	2.97466e-19 (rank : 279)	NC score	0.817370 (rank : 278)
Query Neighborhood Hits	1931	Target Neighborhood Hits	852	Shared Neighborhood Hits	838
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

NEO1_MOUSE
θ value	2.97466e-19 (rank : 280)	NC score	0.409844 (rank : 866)
Query Neighborhood Hits	1931	Target Neighborhood Hits	523	Shared Neighborhood Hits	388
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

CDKL1_MOUSE
θ value	3.88503e-19 (rank : 281)	NC score	0.815955 (rank : 285)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	821
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

M3K12_HUMAN
θ value	3.88503e-19 (rank : 282)	NC score	0.774060 (rank : 472)
Query Neighborhood Hits	1931	Target Neighborhood Hits	940	Shared Neighborhood Hits	856
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	3.88503e-19 (rank : 283)	NC score	0.774167 (rank : 471)
Query Neighborhood Hits	1931	Target Neighborhood Hits	957	Shared Neighborhood Hits	862
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

MST4_MOUSE
θ value	3.88503e-19 (rank : 284)	NC score	0.817392 (rank : 277)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	838
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

SGK3_HUMAN
θ value	3.88503e-19 (rank : 285)	NC score	0.823029 (rank : 230)
Query Neighborhood Hits	1931	Target Neighborhood Hits	877	Shared Neighborhood Hits	826
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

KGP1A_HUMAN
θ value	5.07402e-19 (rank : 286)	NC score	0.822423 (rank : 233)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	835
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	5.07402e-19 (rank : 287)	NC score	0.822011 (rank : 239)
Query Neighborhood Hits	1931	Target Neighborhood Hits	921	Shared Neighborhood Hits	838
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	5.07402e-19 (rank : 288)	NC score	0.822070 (rank : 237)
Query Neighborhood Hits	1931	Target Neighborhood Hits	922	Shared Neighborhood Hits	838
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

PRKY_HUMAN
θ value	5.07402e-19 (rank : 289)	NC score	0.839561 (rank : 130)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	835
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

STK25_MOUSE
θ value	5.07402e-19 (rank : 290)	NC score	0.816440 (rank : 282)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	837
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

KPCD_MOUSE
θ value	6.62687e-19 (rank : 291)	NC score	0.814105 (rank : 303)
Query Neighborhood Hits	1931	Target Neighborhood Hits	888	Shared Neighborhood Hits	839
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

ST32B_MOUSE
θ value	6.62687e-19 (rank : 292)	NC score	0.829122 (rank : 194)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	820
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

TTK_HUMAN
θ value	6.62687e-19 (rank : 293)	NC score	0.819904 (rank : 255)
Query Neighborhood Hits	1931	Target Neighborhood Hits	816	Shared Neighborhood Hits	775
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

NEO1_HUMAN
θ value	8.65492e-19 (rank : 294)	NC score	0.411143 (rank : 863)
Query Neighborhood Hits	1931	Target Neighborhood Hits	530	Shared Neighborhood Hits	386
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

PUNC_MOUSE
θ value	8.65492e-19 (rank : 295)	NC score	0.421522 (rank : 845)
Query Neighborhood Hits	1931	Target Neighborhood Hits	501	Shared Neighborhood Hits	374
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

TAOK1_MOUSE
θ value	8.65492e-19 (rank : 296)	NC score	0.761214 (rank : 508)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1720	Shared Neighborhood Hits	884
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

CDKL5_HUMAN
θ value	1.13037e-18 (rank : 297)	NC score	0.814664 (rank : 298)
Query Neighborhood Hits	1931	Target Neighborhood Hits	967	Shared Neighborhood Hits	847
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CNTN2_MOUSE
θ value	1.13037e-18 (rank : 298)	NC score	0.407597 (rank : 870)
Query Neighborhood Hits	1931	Target Neighborhood Hits	450	Shared Neighborhood Hits	392
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

TAOK1_HUMAN
θ value	1.13037e-18 (rank : 299)	NC score	0.760820 (rank : 509)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1734	Shared Neighborhood Hits	888
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

FGRL1_MOUSE
θ value	1.47631e-18 (rank : 300)	NC score	0.415377 (rank : 856)
Query Neighborhood Hits	1931	Target Neighborhood Hits	325	Shared Neighborhood Hits	302
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

KPCD_HUMAN
θ value	1.47631e-18 (rank : 301)	NC score	0.814650 (rank : 299)
Query Neighborhood Hits	1931	Target Neighborhood Hits	900	Shared Neighborhood Hits	842
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

STK25_HUMAN
θ value	1.47631e-18 (rank : 302)	NC score	0.816854 (rank : 279)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	838
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

KPCG_MOUSE
θ value	1.92812e-18 (rank : 303)	NC score	0.793055 (rank : 398)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1123	Shared Neighborhood Hits	851
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

LATS1_HUMAN
θ value	1.92812e-18 (rank : 304)	NC score	0.793168 (rank : 397)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1057	Shared Neighborhood Hits	871
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

MAPK5_HUMAN
θ value	1.92812e-18 (rank : 305)	NC score	0.825700 (rank : 214)
Query Neighborhood Hits	1931	Target Neighborhood Hits	795	Shared Neighborhood Hits	784
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

NCA11_MOUSE
θ value	1.92812e-18 (rank : 306)	NC score	0.416352 (rank : 855)
Query Neighborhood Hits	1931	Target Neighborhood Hits	661	Shared Neighborhood Hits	447
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NCA12_MOUSE
θ value	1.92812e-18 (rank : 307)	NC score	0.420051 (rank : 849)
Query Neighborhood Hits	1931	Target Neighborhood Hits	399	Shared Neighborhood Hits	364
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

STK39_HUMAN
θ value	1.92812e-18 (rank : 308)	NC score	0.819195 (rank : 262)
Query Neighborhood Hits	1931	Target Neighborhood Hits	882	Shared Neighborhood Hits	845
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	1.92812e-18 (rank : 309)	NC score	0.819328 (rank : 259)
Query Neighborhood Hits	1931	Target Neighborhood Hits	915	Shared Neighborhood Hits	852
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

TAOK3_HUMAN
θ value	1.92812e-18 (rank : 310)	NC score	0.772353 (rank : 478)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1494	Shared Neighborhood Hits	873
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TSSK2_HUMAN
θ value	1.92812e-18 (rank : 311)	NC score	0.837836 (rank : 142)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	817
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

CNTN2_HUMAN
θ value	2.5182e-18 (rank : 312)	NC score	0.407616 (rank : 869)
Query Neighborhood Hits	1931	Target Neighborhood Hits	440	Shared Neighborhood Hits	386
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

DCC_HUMAN
θ value	2.5182e-18 (rank : 313)	NC score	0.412137 (rank : 861)
Query Neighborhood Hits	1931	Target Neighborhood Hits	583	Shared Neighborhood Hits	423
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

KPCG_HUMAN
θ value	2.5182e-18 (rank : 314)	NC score	0.792826 (rank : 400)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1126	Shared Neighborhood Hits	851
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

M3K3_HUMAN
θ value	2.5182e-18 (rank : 315)	NC score	0.828952 (rank : 196)
Query Neighborhood Hits	1931	Target Neighborhood Hits	885	Shared Neighborhood Hits	843
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MAPK5_MOUSE
θ value	2.5182e-18 (rank : 316)	NC score	0.826976 (rank : 206)
Query Neighborhood Hits	1931	Target Neighborhood Hits	799	Shared Neighborhood Hits	789
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MYOTI_HUMAN
θ value	2.5182e-18 (rank : 317)	NC score	0.418722 (rank : 852)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	275
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

PAK1_MOUSE
θ value	2.5182e-18 (rank : 318)	NC score	0.830344 (rank : 185)
Query Neighborhood Hits	1931	Target Neighborhood Hits	878	Shared Neighborhood Hits	847
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK3_HUMAN
θ value	2.5182e-18 (rank : 319)	NC score	0.830776 (rank : 179)
Query Neighborhood Hits	1931	Target Neighborhood Hits	887	Shared Neighborhood Hits	849
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	2.5182e-18 (rank : 320)	NC score	0.831045 (rank : 178)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	846
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

SGK1_HUMAN
θ value	2.5182e-18 (rank : 321)	NC score	0.829199 (rank : 191)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	834
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

CDK7_HUMAN
θ value	3.28887e-18 (rank : 322)	NC score	0.801309 (rank : 357)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	821
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	3.28887e-18 (rank : 323)	NC score	0.801472 (rank : 356)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	821
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

MYOTI_MOUSE
θ value	3.28887e-18 (rank : 324)	NC score	0.418548 (rank : 853)
Query Neighborhood Hits	1931	Target Neighborhood Hits	297	Shared Neighborhood Hits	273
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

ST32B_HUMAN
θ value	3.28887e-18 (rank : 325)	NC score	0.828534 (rank : 199)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

LRIG1_MOUSE
θ value	4.29542e-18 (rank : 326)	NC score	0.301126 (rank : 977)
Query Neighborhood Hits	1931	Target Neighborhood Hits	627	Shared Neighborhood Hits	332
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

SGK1_MOUSE
θ value	4.29542e-18 (rank : 327)	NC score	0.828836 (rank : 197)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	834
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

TTK_MOUSE
θ value	4.29542e-18 (rank : 328)	NC score	0.818518 (rank : 270)
Query Neighborhood Hits	1931	Target Neighborhood Hits	803	Shared Neighborhood Hits	759
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

MRCKG_MOUSE
θ value	5.60996e-18 (rank : 329)	NC score	0.771993 (rank : 482)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1466	Shared Neighborhood Hits	864
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PAK1_HUMAN
θ value	5.60996e-18 (rank : 330)	NC score	0.830735 (rank : 180)
Query Neighborhood Hits	1931	Target Neighborhood Hits	873	Shared Neighborhood Hits	845
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK6_HUMAN
θ value	5.60996e-18 (rank : 331)	NC score	0.834263 (rank : 153)
Query Neighborhood Hits	1931	Target Neighborhood Hits	915	Shared Neighborhood Hits	860
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PUNC_HUMAN
θ value	5.60996e-18 (rank : 332)	NC score	0.420611 (rank : 847)
Query Neighborhood Hits	1931	Target Neighborhood Hits	449	Shared Neighborhood Hits	345
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

LRIG2_HUMAN
θ value	7.32683e-18 (rank : 333)	NC score	0.303030 (rank : 973)
Query Neighborhood Hits	1931	Target Neighborhood Hits	595	Shared Neighborhood Hits	325
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

M3K1_MOUSE
θ value	9.56915e-18 (rank : 334)	NC score	0.830361 (rank : 184)
Query Neighborhood Hits	1931	Target Neighborhood Hits	952	Shared Neighborhood Hits	857
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_MOUSE
θ value	9.56915e-18 (rank : 335)	NC score	0.829250 (rank : 190)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	832
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

NEK9_HUMAN
θ value	9.56915e-18 (rank : 336)	NC score	0.813001 (rank : 308)
Query Neighborhood Hits	1931	Target Neighborhood Hits	900	Shared Neighborhood Hits	841
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

PAK4_HUMAN
θ value	9.56915e-18 (rank : 337)	NC score	0.833384 (rank : 162)
Query Neighborhood Hits	1931	Target Neighborhood Hits	924	Shared Neighborhood Hits	872
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PLK1_MOUSE
θ value	9.56915e-18 (rank : 338)	NC score	0.846069 (rank : 66)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	831
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

CDC2_HUMAN
θ value	1.24977e-17 (rank : 339)	NC score	0.807267 (rank : 332)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	831
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CNTN1_HUMAN
θ value	1.24977e-17 (rank : 340)	NC score	0.398206 (rank : 890)
Query Neighborhood Hits	1931	Target Neighborhood Hits	431	Shared Neighborhood Hits	356
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

M3K3_MOUSE
θ value	1.24977e-17 (rank : 341)	NC score	0.829170 (rank : 192)
Query Neighborhood Hits	1931	Target Neighborhood Hits	876	Shared Neighborhood Hits	841
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

TAOK3_MOUSE
θ value	1.24977e-17 (rank : 342)	NC score	0.774637 (rank : 469)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1458	Shared Neighborhood Hits	867
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

CDK3_HUMAN
θ value	1.63225e-17 (rank : 343)	NC score	0.804110 (rank : 348)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	829
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDON_MOUSE
θ value	1.63225e-17 (rank : 344)	NC score	0.414125 (rank : 858)
Query Neighborhood Hits	1931	Target Neighborhood Hits	410	Shared Neighborhood Hits	346
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CNTN3_HUMAN
θ value	1.63225e-17 (rank : 345)	NC score	0.402007 (rank : 881)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	375
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

LRIG1_HUMAN
θ value	1.63225e-17 (rank : 346)	NC score	0.307561 (rank : 968)
Query Neighborhood Hits	1931	Target Neighborhood Hits	654	Shared Neighborhood Hits	347
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

CDON_HUMAN
θ value	2.13179e-17 (rank : 347)	NC score	0.414132 (rank : 857)
Query Neighborhood Hits	1931	Target Neighborhood Hits	412	Shared Neighborhood Hits	331
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

M4K1_HUMAN
θ value	2.13179e-17 (rank : 348)	NC score	0.810725 (rank : 324)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	840
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

NEK4_MOUSE
θ value	2.13179e-17 (rank : 349)	NC score	0.832779 (rank : 165)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	844
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

CDC2_MOUSE
θ value	2.7842e-17 (rank : 350)	NC score	0.806538 (rank : 338)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	830
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDKL2_MOUSE
θ value	2.7842e-17 (rank : 351)	NC score	0.812804 (rank : 309)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	828
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

M4K1_MOUSE
θ value	2.7842e-17 (rank : 352)	NC score	0.809932 (rank : 325)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	837
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

SBK1_MOUSE
θ value	2.7842e-17 (rank : 353)	NC score	0.840722 (rank : 114)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	811
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

CDK2_MOUSE
θ value	3.63628e-17 (rank : 354)	NC score	0.800121 (rank : 361)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	820
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDKL3_MOUSE
θ value	3.63628e-17 (rank : 355)	NC score	0.819051 (rank : 265)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	831
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

DMPK_HUMAN
θ value	3.63628e-17 (rank : 356)	NC score	0.804375 (rank : 347)
Query Neighborhood Hits	1931	Target Neighborhood Hits	944	Shared Neighborhood Hits	828
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

KPCT_MOUSE
θ value	3.63628e-17 (rank : 357)	NC score	0.819626 (rank : 257)
Query Neighborhood Hits	1931	Target Neighborhood Hits	895	Shared Neighborhood Hits	840
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

LATS1_MOUSE
θ value	3.63628e-17 (rank : 358)	NC score	0.790607 (rank : 411)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1027	Shared Neighborhood Hits	850
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

M3K6_HUMAN
θ value	3.63628e-17 (rank : 359)	NC score	0.825863 (rank : 212)
Query Neighborhood Hits	1931	Target Neighborhood Hits	889	Shared Neighborhood Hits	847
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M4K5_HUMAN
θ value	3.63628e-17 (rank : 360)	NC score	0.805217 (rank : 342)
Query Neighborhood Hits	1931	Target Neighborhood Hits	845	Shared Neighborhood Hits	828
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

NEK2_HUMAN
θ value	3.63628e-17 (rank : 361)	NC score	0.834804 (rank : 149)
Query Neighborhood Hits	1931	Target Neighborhood Hits	908	Shared Neighborhood Hits	826
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

CDK6_HUMAN
θ value	4.74913e-17 (rank : 362)	NC score	0.797871 (rank : 370)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	828
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

KPCI_HUMAN
θ value	4.74913e-17 (rank : 363)	NC score	0.818957 (rank : 267)
Query Neighborhood Hits	1931	Target Neighborhood Hits	885	Shared Neighborhood Hits	845
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	4.74913e-17 (rank : 364)	NC score	0.819058 (rank : 264)
Query Neighborhood Hits	1931	Target Neighborhood Hits	888	Shared Neighborhood Hits	845
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

M4K5_MOUSE
θ value	4.74913e-17 (rank : 365)	NC score	0.806458 (rank : 339)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	824
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MRCKG_HUMAN
θ value	4.74913e-17 (rank : 366)	NC score	0.772942 (rank : 476)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1519	Shared Neighborhood Hits	879
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PIM2_HUMAN
θ value	4.74913e-17 (rank : 367)	NC score	0.826096 (rank : 209)
Query Neighborhood Hits	1931	Target Neighborhood Hits	808	Shared Neighborhood Hits	803
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PKN2_HUMAN
θ value	4.74913e-17 (rank : 368)	NC score	0.819937 (rank : 254)
Query Neighborhood Hits	1931	Target Neighborhood Hits	892	Shared Neighborhood Hits	828
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

SGK2_HUMAN
θ value	4.74913e-17 (rank : 369)	NC score	0.828352 (rank : 200)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

CDKL2_HUMAN
θ value	6.20254e-17 (rank : 370)	NC score	0.812146 (rank : 317)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	825
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

ERN2_MOUSE
θ value	6.20254e-17 (rank : 371)	NC score	0.788728 (rank : 419)
Query Neighborhood Hits	1931	Target Neighborhood Hits	825	Shared Neighborhood Hits	811
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

M3K2_HUMAN
θ value	6.20254e-17 (rank : 372)	NC score	0.828044 (rank : 203)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	836
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MKNK1_HUMAN
θ value	6.20254e-17 (rank : 373)	NC score	0.797650 (rank : 371)
Query Neighborhood Hits	1931	Target Neighborhood Hits	701	Shared Neighborhood Hits	690
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

IKKA_MOUSE
θ value	8.10077e-17 (rank : 374)	NC score	0.825841 (rank : 213)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	835
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MP2K1_HUMAN
θ value	8.10077e-17 (rank : 375)	NC score	0.815273 (rank : 290)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	821
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	8.10077e-17 (rank : 376)	NC score	0.815164 (rank : 292)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	821
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MRCKA_HUMAN
θ value	8.10077e-17 (rank : 377)	NC score	0.722983 (rank : 567)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1999	Shared Neighborhood Hits	889
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

NEK4_HUMAN
θ value	8.10077e-17 (rank : 378)	NC score	0.831282 (rank : 177)
Query Neighborhood Hits	1931	Target Neighborhood Hits	883	Shared Neighborhood Hits	836
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

PKN2_MOUSE
θ value	8.10077e-17 (rank : 379)	NC score	0.820183 (rank : 253)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	830
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

TSSK1_MOUSE
θ value	8.10077e-17 (rank : 380)	NC score	0.838840 (rank : 138)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	822
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MRCKB_HUMAN
θ value	1.058e-16 (rank : 381)	NC score	0.703367 (rank : 597)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2239	Shared Neighborhood Hits	922
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PAK4_MOUSE
θ value	1.058e-16 (rank : 382)	NC score	0.832173 (rank : 173)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1098	Shared Neighborhood Hits	926
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK7_HUMAN
θ value	1.058e-16 (rank : 383)	NC score	0.832654 (rank : 168)
Query Neighborhood Hits	1931	Target Neighborhood Hits	875	Shared Neighborhood Hits	850
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

CDK6_MOUSE
θ value	1.38178e-16 (rank : 384)	NC score	0.798228 (rank : 367)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	828
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CNTN6_MOUSE
θ value	1.38178e-16 (rank : 385)	NC score	0.401856 (rank : 883)
Query Neighborhood Hits	1931	Target Neighborhood Hits	429	Shared Neighborhood Hits	367
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

GRK5_HUMAN
θ value	1.38178e-16 (rank : 386)	NC score	0.814794 (rank : 297)
Query Neighborhood Hits	1931	Target Neighborhood Hits	819	Shared Neighborhood Hits	811
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

L1CAM_HUMAN
θ value	1.38178e-16 (rank : 387)	NC score	0.402443 (rank : 880)
Query Neighborhood Hits	1931	Target Neighborhood Hits	457	Shared Neighborhood Hits	379
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CNTN1_MOUSE
θ value	1.80466e-16 (rank : 388)	NC score	0.398221 (rank : 889)
Query Neighborhood Hits	1931	Target Neighborhood Hits	422	Shared Neighborhood Hits	359
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

M3K15_HUMAN
θ value	1.80466e-16 (rank : 389)	NC score	0.822562 (rank : 231)
Query Neighborhood Hits	1931	Target Neighborhood Hits	914	Shared Neighborhood Hits	840
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

NEK9_MOUSE
θ value	1.80466e-16 (rank : 390)	NC score	0.812325 (rank : 314)
Query Neighborhood Hits	1931	Target Neighborhood Hits	890	Shared Neighborhood Hits	842
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

PAK7_MOUSE
θ value	1.80466e-16 (rank : 391)	NC score	0.832663 (rank : 167)
Query Neighborhood Hits	1931	Target Neighborhood Hits	875	Shared Neighborhood Hits	850
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

SBK1_HUMAN
θ value	1.80466e-16 (rank : 392)	NC score	0.839195 (rank : 134)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	811
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

PKN1_MOUSE
θ value	2.35696e-16 (rank : 393)	NC score	0.818476 (rank : 271)
Query Neighborhood Hits	1931	Target Neighborhood Hits	888	Shared Neighborhood Hits	832
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

STK11_HUMAN
θ value	2.35696e-16 (rank : 394)	NC score	0.845875 (rank : 70)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	824
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

CTRO_HUMAN
θ value	3.07829e-16 (rank : 395)	NC score	0.719418 (rank : 574)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2092	Shared Neighborhood Hits	910
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

IKKB_HUMAN
θ value	3.07829e-16 (rank : 396)	NC score	0.822477 (rank : 232)
Query Neighborhood Hits	1931	Target Neighborhood Hits	980	Shared Neighborhood Hits	837
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MK12_MOUSE
θ value	3.07829e-16 (rank : 397)	NC score	0.795081 (rank : 388)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

RK_HUMAN
θ value	3.07829e-16 (rank : 398)	NC score	0.822024 (rank : 238)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	822
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

IKKA_HUMAN
θ value	4.02038e-16 (rank : 399)	NC score	0.823532 (rank : 224)
Query Neighborhood Hits	1931	Target Neighborhood Hits	863	Shared Neighborhood Hits	833
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KPCZ_HUMAN
θ value	4.02038e-16 (rank : 400)	NC score	0.814426 (rank : 301)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	837
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
θ value	4.02038e-16 (rank : 401)	NC score	0.814460 (rank : 300)
Query Neighborhood Hits	1931	Target Neighborhood Hits	882	Shared Neighborhood Hits	836
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

M3K11_HUMAN
θ value	4.02038e-16 (rank : 402)	NC score	0.756914 (rank : 519)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1136	Shared Neighborhood Hits	904
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PKHG1_HUMAN
θ value	4.02038e-16 (rank : 403)	NC score	0.143354 (rank : 1086)
Query Neighborhood Hits	1931	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

DYRK3_HUMAN
θ value	5.25075e-16 (rank : 404)	NC score	0.774285 (rank : 470)
Query Neighborhood Hits	1931	Target Neighborhood Hits	798	Shared Neighborhood Hits	788
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

GRK5_MOUSE
θ value	5.25075e-16 (rank : 405)	NC score	0.815074 (rank : 293)
Query Neighborhood Hits	1931	Target Neighborhood Hits	823	Shared Neighborhood Hits	811
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

LRIG3_HUMAN
θ value	5.25075e-16 (rank : 406)	NC score	0.287645 (rank : 988)
Query Neighborhood Hits	1931	Target Neighborhood Hits	601	Shared Neighborhood Hits	326
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

LRIG3_MOUSE
θ value	5.25075e-16 (rank : 407)	NC score	0.290766 (rank : 985)
Query Neighborhood Hits	1931	Target Neighborhood Hits	611	Shared Neighborhood Hits	332
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

MRCKB_MOUSE
θ value	5.25075e-16 (rank : 408)	NC score	0.710368 (rank : 588)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2180	Shared Neighborhood Hits	914
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PIM2_MOUSE
θ value	5.25075e-16 (rank : 409)	NC score	0.826353 (rank : 208)
Query Neighborhood Hits	1931	Target Neighborhood Hits	809	Shared Neighborhood Hits	800
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PKN1_HUMAN
θ value	5.25075e-16 (rank : 410)	NC score	0.818180 (rank : 276)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	839
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

ST32A_HUMAN
θ value	5.25075e-16 (rank : 411)	NC score	0.830217 (rank : 186)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	824
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

TSSK2_MOUSE
θ value	5.25075e-16 (rank : 412)	NC score	0.834813 (rank : 148)
Query Neighborhood Hits	1931	Target Neighborhood Hits	819	Shared Neighborhood Hits	809
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

CDKL3_HUMAN
θ value	6.85773e-16 (rank : 413)	NC score	0.818225 (rank : 275)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	831
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

IKKB_MOUSE
θ value	8.95645e-16 (rank : 414)	NC score	0.821996 (rank : 240)
Query Neighborhood Hits	1931	Target Neighborhood Hits	984	Shared Neighborhood Hits	835
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

M3K8_MOUSE
θ value	8.95645e-16 (rank : 415)	NC score	0.818902 (rank : 269)
Query Neighborhood Hits	1931	Target Neighborhood Hits	815	Shared Neighborhood Hits	801
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

FGFR1_HUMAN
θ value	1.16975e-15 (rank : 416)	NC score	0.749026 (rank : 537)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1069	Shared Neighborhood Hits	1046
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

PFTK1_HUMAN
θ value	1.16975e-15 (rank : 417)	NC score	0.798779 (rank : 365)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	822
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

RK_MOUSE
θ value	1.16975e-15 (rank : 418)	NC score	0.823964 (rank : 222)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	819
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ST32A_MOUSE
θ value	1.16975e-15 (rank : 419)	NC score	0.830597 (rank : 183)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

FGFR1_MOUSE
θ value	1.52774e-15 (rank : 420)	NC score	0.748929 (rank : 538)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1068	Shared Neighborhood Hits	1046
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

IKKE_HUMAN
θ value	1.52774e-15 (rank : 421)	NC score	0.823444 (rank : 226)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	810
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

M3K8_HUMAN
θ value	1.52774e-15 (rank : 422)	NC score	0.819534 (rank : 258)
Query Neighborhood Hits	1931	Target Neighborhood Hits	807	Shared Neighborhood Hits	800
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MAK_MOUSE
θ value	1.52774e-15 (rank : 423)	NC score	0.801998 (rank : 353)
Query Neighborhood Hits	1931	Target Neighborhood Hits	873	Shared Neighborhood Hits	837
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MP2K2_HUMAN
θ value	1.52774e-15 (rank : 424)	NC score	0.815953 (rank : 286)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MYO3B_HUMAN
θ value	1.52774e-15 (rank : 425)	NC score	0.705676 (rank : 596)
Query Neighborhood Hits	1931	Target Neighborhood Hits	923	Shared Neighborhood Hits	843
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

PFTK1_MOUSE
θ value	1.99529e-15 (rank : 426)	NC score	0.799053 (rank : 364)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	822
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

L1CAM_MOUSE
θ value	2.60593e-15 (rank : 427)	NC score	0.402759 (rank : 879)
Query Neighborhood Hits	1931	Target Neighborhood Hits	457	Shared Neighborhood Hits	375
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PMYT1_MOUSE
θ value	2.60593e-15 (rank : 428)	NC score	0.813306 (rank : 306)
Query Neighborhood Hits	1931	Target Neighborhood Hits	910	Shared Neighborhood Hits	853
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

NEK2_MOUSE
θ value	3.40345e-15 (rank : 429)	NC score	0.834029 (rank : 155)
Query Neighborhood Hits	1931	Target Neighborhood Hits	876	Shared Neighborhood Hits	825
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

TLK1_HUMAN
θ value	3.40345e-15 (rank : 430)	NC score	0.808029 (rank : 330)
Query Neighborhood Hits	1931	Target Neighborhood Hits	967	Shared Neighborhood Hits	783
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	3.40345e-15 (rank : 431)	NC score	0.807875 (rank : 331)
Query Neighborhood Hits	1931	Target Neighborhood Hits	947	Shared Neighborhood Hits	779
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TSSK1_HUMAN
θ value	3.40345e-15 (rank : 432)	NC score	0.836776 (rank : 144)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	814
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

BOC_HUMAN
θ value	4.44505e-15 (rank : 433)	NC score	0.419108 (rank : 851)
Query Neighborhood Hits	1931	Target Neighborhood Hits	543	Shared Neighborhood Hits	401
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CNTN6_HUMAN
θ value	4.44505e-15 (rank : 434)	NC score	0.398773 (rank : 887)
Query Neighborhood Hits	1931	Target Neighborhood Hits	422	Shared Neighborhood Hits	364
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

M3K4_HUMAN
θ value	4.44505e-15 (rank : 435)	NC score	0.826086 (rank : 210)
Query Neighborhood Hits	1931	Target Neighborhood Hits	911	Shared Neighborhood Hits	850
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

BOC_MOUSE
θ value	5.8054e-15 (rank : 436)	NC score	0.419489 (rank : 850)
Query Neighborhood Hits	1931	Target Neighborhood Hits	433	Shared Neighborhood Hits	354
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

WNK1_HUMAN
θ value	5.8054e-15 (rank : 437)	NC score	0.781152 (rank : 453)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1158	Shared Neighborhood Hits	854
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	5.8054e-15 (rank : 438)	NC score	0.779910 (rank : 457)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1179	Shared Neighborhood Hits	860
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

CHK1_MOUSE
θ value	7.58209e-15 (rank : 439)	NC score	0.840858 (rank : 113)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	831
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

IKKE_MOUSE
θ value	7.58209e-15 (rank : 440)	NC score	0.821060 (rank : 249)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	815
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

M3K9_HUMAN
θ value	9.90251e-15 (rank : 441)	NC score	0.756911 (rank : 520)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1123	Shared Neighborhood Hits	883
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

ULK4_MOUSE
θ value	9.90251e-15 (rank : 442)	NC score	0.833295 (rank : 163)
Query Neighborhood Hits	1931	Target Neighborhood Hits	793	Shared Neighborhood Hits	773
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

WNK3_HUMAN
θ value	9.90251e-15 (rank : 443)	NC score	0.789900 (rank : 413)
Query Neighborhood Hits	1931	Target Neighborhood Hits	948	Shared Neighborhood Hits	785
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

MP2K2_MOUSE
θ value	1.29331e-14 (rank : 444)	NC score	0.814175 (rank : 302)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	824
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

TBK1_MOUSE
θ value	1.29331e-14 (rank : 445)	NC score	0.821096 (rank : 248)
Query Neighborhood Hits	1931	Target Neighborhood Hits	893	Shared Neighborhood Hits	803
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TLK2_HUMAN
θ value	1.29331e-14 (rank : 446)	NC score	0.806735 (rank : 333)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1044	Shared Neighborhood Hits	804
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	1.29331e-14 (rank : 447)	NC score	0.804400 (rank : 346)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1088	Shared Neighborhood Hits	807
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

ICK_HUMAN
θ value	1.68911e-14 (rank : 448)	NC score	0.801950 (rank : 354)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	834
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

LATS2_MOUSE
θ value	1.68911e-14 (rank : 449)	NC score	0.788977 (rank : 417)
Query Neighborhood Hits	1931	Target Neighborhood Hits	879	Shared Neighborhood Hits	833
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

TBK1_HUMAN
θ value	1.68911e-14 (rank : 450)	NC score	0.821430 (rank : 245)
Query Neighborhood Hits	1931	Target Neighborhood Hits	861	Shared Neighborhood Hits	800
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

WNK4_HUMAN
θ value	1.68911e-14 (rank : 451)	NC score	0.776962 (rank : 464)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1043	Shared Neighborhood Hits	823
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK4_MOUSE
θ value	1.68911e-14 (rank : 452)	NC score	0.782130 (rank : 448)
Query Neighborhood Hits	1931	Target Neighborhood Hits	961	Shared Neighborhood Hits	806
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

FGFR4_MOUSE
θ value	2.20605e-14 (rank : 453)	NC score	0.715060 (rank : 581)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1026	Shared Neighborhood Hits	1011
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

GRK4_MOUSE
θ value	2.20605e-14 (rank : 454)	NC score	0.809026 (rank : 327)
Query Neighborhood Hits	1931	Target Neighborhood Hits	808	Shared Neighborhood Hits	804
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

ICK_MOUSE
θ value	2.20605e-14 (rank : 455)	NC score	0.802679 (rank : 352)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	834
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

M3K4_MOUSE
θ value	2.20605e-14 (rank : 456)	NC score	0.824771 (rank : 219)
Query Neighborhood Hits	1931	Target Neighborhood Hits	924	Shared Neighborhood Hits	848
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_MOUSE
θ value	2.20605e-14 (rank : 457)	NC score	0.823085 (rank : 228)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	833
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

MK04_HUMAN
θ value	2.20605e-14 (rank : 458)	NC score	0.788452 (rank : 422)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	819
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

PCTK1_HUMAN
θ value	2.20605e-14 (rank : 459)	NC score	0.795927 (rank : 383)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

CHK1_HUMAN
θ value	2.88119e-14 (rank : 460)	NC score	0.840163 (rank : 123)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

GRK6_HUMAN
θ value	2.88119e-14 (rank : 461)	NC score	0.816024 (rank : 284)
Query Neighborhood Hits	1931	Target Neighborhood Hits	823	Shared Neighborhood Hits	819
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

M3K5_HUMAN
θ value	2.88119e-14 (rank : 462)	NC score	0.823083 (rank : 229)
Query Neighborhood Hits	1931	Target Neighborhood Hits	868	Shared Neighborhood Hits	833
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

MK12_HUMAN
θ value	2.88119e-14 (rank : 463)	NC score	0.793746 (rank : 392)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PIM1_MOUSE
θ value	2.88119e-14 (rank : 464)	NC score	0.822303 (rank : 234)
Query Neighborhood Hits	1931	Target Neighborhood Hits	787	Shared Neighborhood Hits	781
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

TNIK_HUMAN
θ value	2.88119e-14 (rank : 465)	NC score	0.788667 (rank : 420)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1570	Shared Neighborhood Hits	916
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

CTRO_MOUSE
θ value	3.76295e-14 (rank : 466)	NC score	0.698504 (rank : 607)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2344	Shared Neighborhood Hits	919
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DYR1B_MOUSE
θ value	3.76295e-14 (rank : 467)	NC score	0.768757 (rank : 490)
Query Neighborhood Hits	1931	Target Neighborhood Hits	799	Shared Neighborhood Hits	775
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

MP2K6_MOUSE
θ value	3.76295e-14 (rank : 468)	NC score	0.798220 (rank : 368)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	823
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

ST32C_HUMAN
θ value	3.76295e-14 (rank : 469)	NC score	0.825891 (rank : 211)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	820
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	3.76295e-14 (rank : 470)	NC score	0.827478 (rank : 205)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	815
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ARBK1_HUMAN
θ value	4.91457e-14 (rank : 471)	NC score	0.806538 (rank : 337)
Query Neighborhood Hits	1931	Target Neighborhood Hits	859	Shared Neighborhood Hits	818
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

GRK6_MOUSE
θ value	4.91457e-14 (rank : 472)	NC score	0.815186 (rank : 291)
Query Neighborhood Hits	1931	Target Neighborhood Hits	820	Shared Neighborhood Hits	818
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

HIPK2_HUMAN
θ value	4.91457e-14 (rank : 473)	NC score	0.758867 (rank : 514)
Query Neighborhood Hits	1931	Target Neighborhood Hits	845	Shared Neighborhood Hits	790
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	4.91457e-14 (rank : 474)	NC score	0.758095 (rank : 516)
Query Neighborhood Hits	1931	Target Neighborhood Hits	871	Shared Neighborhood Hits	791
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

LATS2_HUMAN
θ value	4.91457e-14 (rank : 475)	NC score	0.788399 (rank : 423)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	834
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

MINK1_MOUSE
θ value	4.91457e-14 (rank : 476)	NC score	0.789011 (rank : 415)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1451	Shared Neighborhood Hits	898
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK04_MOUSE
θ value	4.91457e-14 (rank : 477)	NC score	0.787182 (rank : 429)
Query Neighborhood Hits	1931	Target Neighborhood Hits	852	Shared Neighborhood Hits	817
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MP2K3_MOUSE
θ value	4.91457e-14 (rank : 478)	NC score	0.801541 (rank : 355)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PCTK1_MOUSE
θ value	4.91457e-14 (rank : 479)	NC score	0.795701 (rank : 384)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	821
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

CEAM5_HUMAN
θ value	6.41864e-14 (rank : 480)	NC score	0.327333 (rank : 953)
Query Neighborhood Hits	1931	Target Neighborhood Hits	343	Shared Neighborhood Hits	289
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

CHL1_MOUSE
θ value	6.41864e-14 (rank : 481)	NC score	0.393507 (rank : 893)
Query Neighborhood Hits	1931	Target Neighborhood Hits	402	Shared Neighborhood Hits	345
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CHL1_HUMAN
θ value	8.38298e-14 (rank : 482)	NC score	0.392393 (rank : 896)
Query Neighborhood Hits	1931	Target Neighborhood Hits	413	Shared Neighborhood Hits	355
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

MINK1_HUMAN
θ value	8.38298e-14 (rank : 483)	NC score	0.788987 (rank : 416)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1477	Shared Neighborhood Hits	917
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK07_HUMAN
θ value	8.38298e-14 (rank : 484)	NC score	0.787145 (rank : 430)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1087	Shared Neighborhood Hits	913
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MYO3A_HUMAN
θ value	8.38298e-14 (rank : 485)	NC score	0.708804 (rank : 591)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1033	Shared Neighborhood Hits	846
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

WEE1B_MOUSE
θ value	8.38298e-14 (rank : 486)	NC score	0.753385 (rank : 528)
Query Neighborhood Hits	1931	Target Neighborhood Hits	765	Shared Neighborhood Hits	740
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

CCRK_MOUSE
θ value	1.09485e-13 (rank : 487)	NC score	0.795260 (rank : 385)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

E2AK1_MOUSE
θ value	1.09485e-13 (rank : 488)	NC score	0.796477 (rank : 378)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	812
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MK06_MOUSE
θ value	1.09485e-13 (rank : 489)	NC score	0.777516 (rank : 463)
Query Neighborhood Hits	1931	Target Neighborhood Hits	818	Shared Neighborhood Hits	796
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MP2K6_HUMAN
θ value	1.09485e-13 (rank : 490)	NC score	0.797163 (rank : 373)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

TESK2_MOUSE
θ value	1.09485e-13 (rank : 491)	NC score	0.767940 (rank : 494)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	814
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

GSK3A_HUMAN
θ value	1.42992e-13 (rank : 492)	NC score	0.796967 (rank : 376)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	810
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

KPCT_HUMAN
θ value	1.42992e-13 (rank : 493)	NC score	0.819252 (rank : 261)
Query Neighborhood Hits	1931	Target Neighborhood Hits	897	Shared Neighborhood Hits	843
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

LSAMP_HUMAN
θ value	1.42992e-13 (rank : 494)	NC score	0.400065 (rank : 885)
Query Neighborhood Hits	1931	Target Neighborhood Hits	347	Shared Neighborhood Hits	321
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

MK01_HUMAN
θ value	1.42992e-13 (rank : 495)	NC score	0.782616 (rank : 446)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	825
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK06_HUMAN
θ value	1.42992e-13 (rank : 496)	NC score	0.777814 (rank : 462)
Query Neighborhood Hits	1931	Target Neighborhood Hits	815	Shared Neighborhood Hits	795
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MP2K3_HUMAN
θ value	1.42992e-13 (rank : 497)	NC score	0.799818 (rank : 362)
Query Neighborhood Hits	1931	Target Neighborhood Hits	825	Shared Neighborhood Hits	819
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K5_HUMAN
θ value	1.42992e-13 (rank : 498)	NC score	0.808928 (rank : 328)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	825
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

ARBK1_MOUSE
θ value	1.86753e-13 (rank : 499)	NC score	0.805729 (rank : 340)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	816
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

HIPK1_HUMAN
θ value	1.86753e-13 (rank : 500)	NC score	0.760098 (rank : 511)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	792
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	1.86753e-13 (rank : 501)	NC score	0.759950 (rank : 512)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	790
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

MAMC1_HUMAN
θ value	1.86753e-13 (rank : 502)	NC score	0.383955 (rank : 902)
Query Neighborhood Hits	1931	Target Neighborhood Hits	357	Shared Neighborhood Hits	311
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MK01_MOUSE
θ value	1.86753e-13 (rank : 503)	NC score	0.782433 (rank : 447)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	825
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK07_MOUSE
θ value	1.86753e-13 (rank : 504)	NC score	0.787909 (rank : 424)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1054	Shared Neighborhood Hits	900
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

AL2S7_HUMAN
θ value	2.43908e-13 (rank : 505)	NC score	0.788774 (rank : 418)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	819
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

DYRK4_HUMAN
θ value	2.43908e-13 (rank : 506)	NC score	0.759192 (rank : 513)
Query Neighborhood Hits	1931	Target Neighborhood Hits	750	Shared Neighborhood Hits	742
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

HIPK3_HUMAN
θ value	2.43908e-13 (rank : 507)	NC score	0.760409 (rank : 510)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	801
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	2.43908e-13 (rank : 508)	NC score	0.762372 (rank : 505)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	804
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

LRRK2_HUMAN
θ value	2.43908e-13 (rank : 509)	NC score	0.691299 (rank : 614)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1382	Shared Neighborhood Hits	861
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

MAK_HUMAN
θ value	2.43908e-13 (rank : 510)	NC score	0.800423 (rank : 360)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	830
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PIM1_HUMAN
θ value	2.43908e-13 (rank : 511)	NC score	0.822283 (rank : 235)
Query Neighborhood Hits	1931	Target Neighborhood Hits	797	Shared Neighborhood Hits	793
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

DYR1B_HUMAN
θ value	3.18553e-13 (rank : 512)	NC score	0.765155 (rank : 502)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	777
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

M3K14_HUMAN
θ value	3.18553e-13 (rank : 513)	NC score	0.819163 (rank : 263)
Query Neighborhood Hits	1931	Target Neighborhood Hits	887	Shared Neighborhood Hits	837
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

MAMC1_MOUSE
θ value	3.18553e-13 (rank : 514)	NC score	0.382463 (rank : 903)
Query Neighborhood Hits	1931	Target Neighborhood Hits	357	Shared Neighborhood Hits	309
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MP2K5_MOUSE
θ value	3.18553e-13 (rank : 515)	NC score	0.813046 (rank : 307)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

CCRK_HUMAN
θ value	4.16044e-13 (rank : 516)	NC score	0.796101 (rank : 382)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	824
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

FGFR4_HUMAN
θ value	4.16044e-13 (rank : 517)	NC score	0.734232 (rank : 559)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1037	Shared Neighborhood Hits	1025
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

MK08_HUMAN
θ value	4.16044e-13 (rank : 518)	NC score	0.782696 (rank : 445)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	825
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	4.16044e-13 (rank : 519)	NC score	0.783281 (rank : 443)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	825
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MYOM2_HUMAN
θ value	4.16044e-13 (rank : 520)	NC score	0.371836 (rank : 916)
Query Neighborhood Hits	1931	Target Neighborhood Hits	341	Shared Neighborhood Hits	286
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

ARBK2_HUMAN
θ value	5.43371e-13 (rank : 521)	NC score	0.806564 (rank : 336)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	817
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

CDK3_MOUSE
θ value	5.43371e-13 (rank : 522)	NC score	0.805567 (rank : 341)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	820
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

GRK4_HUMAN
θ value	5.43371e-13 (rank : 523)	NC score	0.811611 (rank : 320)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	812
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

MK13_HUMAN
θ value	5.43371e-13 (rank : 524)	NC score	0.789623 (rank : 414)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	824
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

NPHN_MOUSE
θ value	5.43371e-13 (rank : 525)	NC score	0.372087 (rank : 915)
Query Neighborhood Hits	1931	Target Neighborhood Hits	370	Shared Neighborhood Hits	311
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NRK_HUMAN
θ value	5.43371e-13 (rank : 526)	NC score	0.798039 (rank : 369)
Query Neighborhood Hits	1931	Target Neighborhood Hits	931	Shared Neighborhood Hits	838
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

PASK_MOUSE
θ value	5.43371e-13 (rank : 527)	NC score	0.839709 (rank : 128)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	830
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

LSAMP_MOUSE
θ value	7.09661e-13 (rank : 528)	NC score	0.399467 (rank : 886)
Query Neighborhood Hits	1931	Target Neighborhood Hits	344	Shared Neighborhood Hits	320
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

MK03_HUMAN
θ value	7.09661e-13 (rank : 529)	NC score	0.785471 (rank : 435)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	826
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	7.09661e-13 (rank : 530)	NC score	0.785440 (rank : 436)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	826
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK15_HUMAN
θ value	7.09661e-13 (rank : 531)	NC score	0.800442 (rank : 359)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1038	Shared Neighborhood Hits	902
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

NEGR1_HUMAN
θ value	7.09661e-13 (rank : 532)	NC score	0.390445 (rank : 898)
Query Neighborhood Hits	1931	Target Neighborhood Hits	346	Shared Neighborhood Hits	312
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

NPHN_HUMAN
θ value	7.09661e-13 (rank : 533)	NC score	0.375782 (rank : 912)
Query Neighborhood Hits	1931	Target Neighborhood Hits	362	Shared Neighborhood Hits	310
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

PCTK3_HUMAN
θ value	7.09661e-13 (rank : 534)	NC score	0.794566 (rank : 389)
Query Neighborhood Hits	1931	Target Neighborhood Hits	827	Shared Neighborhood Hits	815
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PTK6_HUMAN
θ value	7.09661e-13 (rank : 535)	NC score	0.700099 (rank : 605)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1020	Shared Neighborhood Hits	848
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

VGFR2_HUMAN
θ value	7.09661e-13 (rank : 536)	NC score	0.710565 (rank : 587)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1103	Shared Neighborhood Hits	1051
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

CDK5_HUMAN
θ value	9.26847e-13 (rank : 537)	NC score	0.796464 (rank : 379)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

MOK_MOUSE
θ value	9.26847e-13 (rank : 538)	NC score	0.787349 (rank : 428)
Query Neighborhood Hits	1931	Target Neighborhood Hits	796	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

OPCM_HUMAN
θ value	9.26847e-13 (rank : 539)	NC score	0.395659 (rank : 891)
Query Neighborhood Hits	1931	Target Neighborhood Hits	332	Shared Neighborhood Hits	309
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

PCTK3_MOUSE
θ value	9.26847e-13 (rank : 540)	NC score	0.796990 (rank : 375)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	820
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

MDGA1_HUMAN
θ value	1.2105e-12 (rank : 541)	NC score	0.378182 (rank : 909)
Query Neighborhood Hits	1931	Target Neighborhood Hits	358	Shared Neighborhood Hits	309
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

MK10_MOUSE
θ value	1.2105e-12 (rank : 542)	NC score	0.781276 (rank : 452)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	827
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_HUMAN
θ value	1.58096e-12 (rank : 543)	NC score	0.781584 (rank : 451)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	826
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

NLK_HUMAN
θ value	1.58096e-12 (rank : 544)	NC score	0.787660 (rank : 427)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	828
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	1.58096e-12 (rank : 545)	NC score	0.787693 (rank : 425)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	828
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NRK_MOUSE
θ value	1.58096e-12 (rank : 546)	NC score	0.797110 (rank : 374)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	839
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

CDK5_MOUSE
θ value	2.0648e-12 (rank : 547)	NC score	0.796268 (rank : 381)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

NEGR1_MOUSE
θ value	2.0648e-12 (rank : 548)	NC score	0.389016 (rank : 899)
Query Neighborhood Hits	1931	Target Neighborhood Hits	349	Shared Neighborhood Hits	311
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

PMYT1_HUMAN
θ value	2.0648e-12 (rank : 549)	NC score	0.808080 (rank : 329)
Query Neighborhood Hits	1931	Target Neighborhood Hits	814	Shared Neighborhood Hits	803
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

TESK2_HUMAN
θ value	2.0648e-12 (rank : 550)	NC score	0.767901 (rank : 495)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	820
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

MK13_MOUSE
θ value	2.69671e-12 (rank : 551)	NC score	0.790708 (rank : 410)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_HUMAN
θ value	2.69671e-12 (rank : 552)	NC score	0.791530 (rank : 409)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK14_MOUSE
θ value	2.69671e-12 (rank : 553)	NC score	0.791767 (rank : 408)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

VGFR2_MOUSE
θ value	2.69671e-12 (rank : 554)	NC score	0.712425 (rank : 584)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1089	Shared Neighborhood Hits	1046
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

GSK3B_HUMAN
θ value	3.52202e-12 (rank : 555)	NC score	0.793592 (rank : 393)
Query Neighborhood Hits	1931	Target Neighborhood Hits	801	Shared Neighborhood Hits	795
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	3.52202e-12 (rank : 556)	NC score	0.793574 (rank : 394)
Query Neighborhood Hits	1931	Target Neighborhood Hits	800	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

M3K10_HUMAN
θ value	3.52202e-12 (rank : 557)	NC score	0.754707 (rank : 527)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1071	Shared Neighborhood Hits	864
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MK09_HUMAN
θ value	3.52202e-12 (rank : 558)	NC score	0.787693 (rank : 426)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	831
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK09_MOUSE
θ value	3.52202e-12 (rank : 559)	NC score	0.784246 (rank : 441)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	827
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK11_MOUSE
θ value	3.52202e-12 (rank : 560)	NC score	0.786407 (rank : 433)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	824
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MYO3A_MOUSE
θ value	3.52202e-12 (rank : 561)	NC score	0.715869 (rank : 580)
Query Neighborhood Hits	1931	Target Neighborhood Hits	902	Shared Neighborhood Hits	836
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

WEE1B_HUMAN
θ value	3.52202e-12 (rank : 562)	NC score	0.752213 (rank : 532)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	753
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1_MOUSE
θ value	3.52202e-12 (rank : 563)	NC score	0.779788 (rank : 460)
Query Neighborhood Hits	1931	Target Neighborhood Hits	794	Shared Neighborhood Hits	762
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

GRK7_HUMAN
θ value	4.59992e-12 (rank : 564)	NC score	0.812214 (rank : 315)
Query Neighborhood Hits	1931	Target Neighborhood Hits	820	Shared Neighborhood Hits	813
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

M3K14_MOUSE
θ value	4.59992e-12 (rank : 565)	NC score	0.816806 (rank : 280)
Query Neighborhood Hits	1931	Target Neighborhood Hits	889	Shared Neighborhood Hits	834
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MYOM1_HUMAN
θ value	4.59992e-12 (rank : 566)	NC score	0.360237 (rank : 920)
Query Neighborhood Hits	1931	Target Neighborhood Hits	405	Shared Neighborhood Hits	299
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

ARHG9_MOUSE
θ value	6.00763e-12 (rank : 567)	NC score	0.123267 (rank : 1117)
Query Neighborhood Hits	1931	Target Neighborhood Hits	234	Shared Neighborhood Hits	90
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

KIRR2_MOUSE
θ value	6.00763e-12 (rank : 568)	NC score	0.352871 (rank : 924)
Query Neighborhood Hits	1931	Target Neighborhood Hits	326	Shared Neighborhood Hits	271
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

NTRI_HUMAN
θ value	6.00763e-12 (rank : 569)	NC score	0.392150 (rank : 897)
Query Neighborhood Hits	1931	Target Neighborhood Hits	344	Shared Neighborhood Hits	317
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

TXK_HUMAN
θ value	6.00763e-12 (rank : 570)	NC score	0.681609 (rank : 630)
Query Neighborhood Hits	1931	Target Neighborhood Hits	971	Shared Neighborhood Hits	831
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

DYRK2_HUMAN
θ value	7.84624e-12 (rank : 571)	NC score	0.772238 (rank : 479)
Query Neighborhood Hits	1931	Target Neighborhood Hits	799	Shared Neighborhood Hits	786
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

FGD3_MOUSE
θ value	7.84624e-12 (rank : 572)	NC score	0.113242 (rank : 1133)
Query Neighborhood Hits	1931	Target Neighborhood Hits	257	Shared Neighborhood Hits	82
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

MP2K7_HUMAN
θ value	7.84624e-12 (rank : 573)	NC score	0.809572 (rank : 326)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	822
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MYOM1_MOUSE
θ value	7.84624e-12 (rank : 574)	NC score	0.368151 (rank : 917)
Query Neighborhood Hits	1931	Target Neighborhood Hits	415	Shared Neighborhood Hits	314
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

ROBO4_HUMAN
θ value	7.84624e-12 (rank : 575)	NC score	0.380943 (rank : 907)
Query Neighborhood Hits	1931	Target Neighborhood Hits	364	Shared Neighborhood Hits	293
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

WNK2_HUMAN
θ value	7.84624e-12 (rank : 576)	NC score	0.772422 (rank : 477)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1407	Shared Neighborhood Hits	922
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

DYR1A_MOUSE
θ value	1.02475e-11 (rank : 577)	NC score	0.756447 (rank : 522)
Query Neighborhood Hits	1931	Target Neighborhood Hits	762	Shared Neighborhood Hits	751
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

E2AK1_HUMAN
θ value	1.02475e-11 (rank : 578)	NC score	0.792048 (rank : 406)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

NTRI_MOUSE
θ value	1.02475e-11 (rank : 579)	NC score	0.392805 (rank : 894)
Query Neighborhood Hits	1931	Target Neighborhood Hits	342	Shared Neighborhood Hits	316
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

PASK_HUMAN
θ value	1.02475e-11 (rank : 580)	NC score	0.835679 (rank : 146)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	826
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PCTK2_MOUSE
θ value	1.02475e-11 (rank : 581)	NC score	0.792437 (rank : 403)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

ROBO4_MOUSE
θ value	1.02475e-11 (rank : 582)	NC score	0.386006 (rank : 900)
Query Neighborhood Hits	1931	Target Neighborhood Hits	358	Shared Neighborhood Hits	295
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

BRAF1_HUMAN
θ value	1.33837e-11 (rank : 583)	NC score	0.752777 (rank : 531)
Query Neighborhood Hits	1931	Target Neighborhood Hits	883	Shared Neighborhood Hits	837
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

CD2L6_HUMAN
θ value	1.33837e-11 (rank : 584)	NC score	0.773459 (rank : 474)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	822
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	1.33837e-11 (rank : 585)	NC score	0.773528 (rank : 473)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	824
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CDK10_HUMAN
θ value	1.33837e-11 (rank : 586)	NC score	0.783801 (rank : 442)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	826
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

DYR1A_HUMAN
θ value	1.33837e-11 (rank : 587)	NC score	0.756376 (rank : 523)
Query Neighborhood Hits	1931	Target Neighborhood Hits	764	Shared Neighborhood Hits	751
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

LRRK2_MOUSE
θ value	1.33837e-11 (rank : 588)	NC score	0.674567 (rank : 646)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1359	Shared Neighborhood Hits	848
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

MP2K4_HUMAN
θ value	1.33837e-11 (rank : 589)	NC score	0.803402 (rank : 349)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	826
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	1.33837e-11 (rank : 590)	NC score	0.803397 (rank : 350)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	826
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

PTK6_MOUSE
θ value	1.33837e-11 (rank : 591)	NC score	0.698056 (rank : 609)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1026	Shared Neighborhood Hits	850
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

ERN1_HUMAN
θ value	1.74796e-11 (rank : 592)	NC score	0.793178 (rank : 396)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	813
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

PCTK2_HUMAN
θ value	1.74796e-11 (rank : 593)	NC score	0.792663 (rank : 401)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	822
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PIM3_HUMAN
θ value	1.74796e-11 (rank : 594)	NC score	0.821480 (rank : 244)
Query Neighborhood Hits	1931	Target Neighborhood Hits	789	Shared Neighborhood Hits	787
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

CDK8_HUMAN
θ value	2.28291e-11 (rank : 595)	NC score	0.770603 (rank : 488)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	817
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

M3KL4_HUMAN
θ value	2.28291e-11 (rank : 596)	NC score	0.745126 (rank : 541)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1087	Shared Neighborhood Hits	855
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MASTL_HUMAN
θ value	2.28291e-11 (rank : 597)	NC score	0.812147 (rank : 316)
Query Neighborhood Hits	1931	Target Neighborhood Hits	894	Shared Neighborhood Hits	834
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
θ value	2.28291e-11 (rank : 598)	NC score	0.811573 (rank : 321)
Query Neighborhood Hits	1931	Target Neighborhood Hits	862	Shared Neighborhood Hits	830
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

VGFR1_HUMAN
θ value	2.28291e-11 (rank : 599)	NC score	0.720171 (rank : 570)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1109	Shared Neighborhood Hits	1068
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

BTK_HUMAN
θ value	2.98157e-11 (rank : 600)	NC score	0.675387 (rank : 643)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1026	Shared Neighborhood Hits	838
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

MOS_MOUSE
θ value	2.98157e-11 (rank : 601)	NC score	0.750783 (rank : 534)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

VGFR3_MOUSE
θ value	2.98157e-11 (rank : 602)	NC score	0.691389 (rank : 613)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1056	Shared Neighborhood Hits	1024
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

WEE1_HUMAN
θ value	2.98157e-11 (rank : 603)	NC score	0.768495 (rank : 492)
Query Neighborhood Hits	1931	Target Neighborhood Hits	777	Shared Neighborhood Hits	742
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

BTK_MOUSE
θ value	3.89403e-11 (rank : 604)	NC score	0.674532 (rank : 647)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1017	Shared Neighborhood Hits	837
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

FCRL5_HUMAN
θ value	3.89403e-11 (rank : 605)	NC score	0.314606 (rank : 964)
Query Neighborhood Hits	1931	Target Neighborhood Hits	267	Shared Neighborhood Hits	236
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

PIM3_MOUSE
θ value	3.89403e-11 (rank : 606)	NC score	0.819308 (rank : 260)
Query Neighborhood Hits	1931	Target Neighborhood Hits	783	Shared Neighborhood Hits	781
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

SRMS_HUMAN
θ value	3.89403e-11 (rank : 607)	NC score	0.669070 (rank : 656)
Query Neighborhood Hits	1931	Target Neighborhood Hits	946	Shared Neighborhood Hits	833
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

TXK_MOUSE
θ value	3.89403e-11 (rank : 608)	NC score	0.669935 (rank : 654)
Query Neighborhood Hits	1931	Target Neighborhood Hits	980	Shared Neighborhood Hits	820
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CD22_MOUSE
θ value	5.08577e-11 (rank : 609)	NC score	0.356632 (rank : 922)
Query Neighborhood Hits	1931	Target Neighborhood Hits	331	Shared Neighborhood Hits	273
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CSK22_MOUSE
θ value	5.08577e-11 (rank : 610)	NC score	0.779956 (rank : 456)
Query Neighborhood Hits	1931	Target Neighborhood Hits	758	Shared Neighborhood Hits	757
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_HUMAN
θ value	6.64225e-11 (rank : 611)	NC score	0.779801 (rank : 459)
Query Neighborhood Hits	1931	Target Neighborhood Hits	758	Shared Neighborhood Hits	757
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

FGFR2_MOUSE
θ value	6.64225e-11 (rank : 612)	NC score	0.740855 (rank : 547)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1062	Shared Neighborhood Hits	1038
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

GAK_HUMAN
θ value	6.64225e-11 (rank : 613)	NC score	0.770640 (rank : 487)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1028	Shared Neighborhood Hits	870
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

MYBPH_HUMAN
θ value	6.64225e-11 (rank : 614)	NC score	0.347959 (rank : 927)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	237
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

ARHG9_HUMAN
θ value	8.67504e-11 (rank : 615)	NC score	0.122536 (rank : 1119)
Query Neighborhood Hits	1931	Target Neighborhood Hits	235	Shared Neighborhood Hits	91
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

FGFR2_HUMAN
θ value	8.67504e-11 (rank : 616)	NC score	0.744007 (rank : 543)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1062	Shared Neighborhood Hits	1040
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

MYBPH_MOUSE
θ value	8.67504e-11 (rank : 617)	NC score	0.345807 (rank : 930)
Query Neighborhood Hits	1931	Target Neighborhood Hits	290	Shared Neighborhood Hits	246
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

TYK2_HUMAN
θ value	8.67504e-11 (rank : 618)	NC score	0.711841 (rank : 585)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	830
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

BMX_MOUSE
θ value	1.133e-10 (rank : 619)	NC score	0.677485 (rank : 636)
Query Neighborhood Hits	1931	Target Neighborhood Hits	912	Shared Neighborhood Hits	804
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

MOK_HUMAN
θ value	1.133e-10 (rank : 620)	NC score	0.788553 (rank : 421)
Query Neighborhood Hits	1931	Target Neighborhood Hits	807	Shared Neighborhood Hits	800
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

ERN1_MOUSE
θ value	1.47974e-10 (rank : 621)	NC score	0.792025 (rank : 407)
Query Neighborhood Hits	1931	Target Neighborhood Hits	823	Shared Neighborhood Hits	810
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FGFR3_HUMAN
θ value	1.47974e-10 (rank : 622)	NC score	0.737581 (rank : 550)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1042	Shared Neighborhood Hits	1029
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FRK_HUMAN
θ value	1.47974e-10 (rank : 623)	NC score	0.674862 (rank : 645)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1058	Shared Neighborhood Hits	852
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

M3K7_HUMAN
θ value	1.47974e-10 (rank : 624)	NC score	0.766249 (rank : 500)
Query Neighborhood Hits	1931	Target Neighborhood Hits	892	Shared Neighborhood Hits	831
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	1.47974e-10 (rank : 625)	NC score	0.766375 (rank : 499)
Query Neighborhood Hits	1931	Target Neighborhood Hits	892	Shared Neighborhood Hits	832
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

BMX_HUMAN
θ value	1.9326e-10 (rank : 626)	NC score	0.678069 (rank : 635)
Query Neighborhood Hits	1931	Target Neighborhood Hits	942	Shared Neighborhood Hits	811
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

CDK9_HUMAN
θ value	1.9326e-10 (rank : 627)	NC score	0.780641 (rank : 454)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

FGD3_HUMAN
θ value	1.9326e-10 (rank : 628)	NC score	0.109240 (rank : 1140)
Query Neighborhood Hits	1931	Target Neighborhood Hits	249	Shared Neighborhood Hits	88
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

MK15_MOUSE
θ value	1.9326e-10 (rank : 629)	NC score	0.797646 (rank : 372)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	825
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

RAF1_HUMAN
θ value	1.9326e-10 (rank : 630)	NC score	0.752878 (rank : 530)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	841
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

SRMS_MOUSE
θ value	1.9326e-10 (rank : 631)	NC score	0.674037 (rank : 649)
Query Neighborhood Hits	1931	Target Neighborhood Hits	964	Shared Neighborhood Hits	836
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

CD22_HUMAN
θ value	2.52405e-10 (rank : 632)	NC score	0.358058 (rank : 921)
Query Neighborhood Hits	1931	Target Neighborhood Hits	365	Shared Neighborhood Hits	291
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CDK9_MOUSE
θ value	2.52405e-10 (rank : 633)	NC score	0.779895 (rank : 458)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

E2AK2_MOUSE
θ value	2.52405e-10 (rank : 634)	NC score	0.821423 (rank : 246)
Query Neighborhood Hits	1931	Target Neighborhood Hits	864	Shared Neighborhood Hits	836
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

FCRL2_HUMAN
θ value	2.52405e-10 (rank : 635)	NC score	0.305677 (rank : 971)
Query Neighborhood Hits	1931	Target Neighborhood Hits	251	Shared Neighborhood Hits	224
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

FES_HUMAN
θ value	2.52405e-10 (rank : 636)	NC score	0.701235 (rank : 600)
Query Neighborhood Hits	1931	Target Neighborhood Hits	978	Shared Neighborhood Hits	811
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

MAG_HUMAN
θ value	2.52405e-10 (rank : 637)	NC score	0.364478 (rank : 919)
Query Neighborhood Hits	1931	Target Neighborhood Hits	278	Shared Neighborhood Hits	261
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

CSK21_HUMAN
θ value	3.29651e-10 (rank : 638)	NC score	0.784733 (rank : 440)
Query Neighborhood Hits	1931	Target Neighborhood Hits	772	Shared Neighborhood Hits	764
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

MK11_HUMAN
θ value	3.29651e-10 (rank : 639)	NC score	0.779959 (rank : 455)
Query Neighborhood Hits	1931	Target Neighborhood Hits	823	Shared Neighborhood Hits	819
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

RAF1_MOUSE
θ value	3.29651e-10 (rank : 640)	NC score	0.753186 (rank : 529)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	843
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

CDK4_HUMAN
θ value	4.30538e-10 (rank : 641)	NC score	0.786228 (rank : 434)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	826
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	4.30538e-10 (rank : 642)	NC score	0.786418 (rank : 432)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

FGFR3_MOUSE
θ value	4.30538e-10 (rank : 643)	NC score	0.739411 (rank : 548)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1059	Shared Neighborhood Hits	1041
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

M4K4_HUMAN
θ value	4.30538e-10 (rank : 644)	NC score	0.776040 (rank : 468)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1589	Shared Neighborhood Hits	878
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MLTK_HUMAN
θ value	4.30538e-10 (rank : 645)	NC score	0.750015 (rank : 536)
Query Neighborhood Hits	1931	Target Neighborhood Hits	911	Shared Neighborhood Hits	830
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

ARAF_MOUSE
θ value	5.62301e-10 (rank : 646)	NC score	0.747443 (rank : 540)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	835
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

CEA20_HUMAN
θ value	5.62301e-10 (rank : 647)	NC score	0.318028 (rank : 962)
Query Neighborhood Hits	1931	Target Neighborhood Hits	251	Shared Neighborhood Hits	219
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

F5006_HUMAN
θ value	5.62301e-10 (rank : 648)	NC score	0.801147 (rank : 358)
Query Neighborhood Hits	1931	Target Neighborhood Hits	794	Shared Neighborhood Hits	786
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

GAK_MOUSE
θ value	5.62301e-10 (rank : 649)	NC score	0.767877 (rank : 496)
Query Neighborhood Hits	1931	Target Neighborhood Hits	964	Shared Neighborhood Hits	842
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

LIMK1_HUMAN
θ value	5.62301e-10 (rank : 650)	NC score	0.734278 (rank : 558)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1005	Shared Neighborhood Hits	827
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

M4K4_MOUSE
θ value	5.62301e-10 (rank : 651)	NC score	0.772022 (rank : 481)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1560	Shared Neighborhood Hits	877
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MOS_HUMAN
θ value	5.62301e-10 (rank : 652)	NC score	0.751528 (rank : 533)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	826
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ARAF_HUMAN
θ value	7.34386e-10 (rank : 653)	NC score	0.747793 (rank : 539)
Query Neighborhood Hits	1931	Target Neighborhood Hits	924	Shared Neighborhood Hits	847
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

FGD4_HUMAN
θ value	7.34386e-10 (rank : 654)	NC score	0.103507 (rank : 1156)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	68
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

CEAM1_MOUSE
θ value	9.59137e-10 (rank : 655)	NC score	0.319724 (rank : 958)
Query Neighborhood Hits	1931	Target Neighborhood Hits	326	Shared Neighborhood Hits	280
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

ITK_MOUSE
θ value	9.59137e-10 (rank : 656)	NC score	0.676346 (rank : 640)
Query Neighborhood Hits	1931	Target Neighborhood Hits	985	Shared Neighborhood Hits	843
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

KIRR2_HUMAN
θ value	9.59137e-10 (rank : 657)	NC score	0.355784 (rank : 923)
Query Neighborhood Hits	1931	Target Neighborhood Hits	321	Shared Neighborhood Hits	271
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

PREX1_HUMAN
θ value	9.59137e-10 (rank : 658)	NC score	0.117039 (rank : 1128)
Query Neighborhood Hits	1931	Target Neighborhood Hits	177	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

TESK1_MOUSE
θ value	9.59137e-10 (rank : 659)	NC score	0.767419 (rank : 498)
Query Neighborhood Hits	1931	Target Neighborhood Hits	862	Shared Neighborhood Hits	820
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

VGFR1_MOUSE
θ value	9.59137e-10 (rank : 660)	NC score	0.724194 (rank : 566)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1118	Shared Neighborhood Hits	1072
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

ABL1_MOUSE
θ value	1.25267e-09 (rank : 661)	NC score	0.679866 (rank : 632)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1178	Shared Neighborhood Hits	904
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CSK21_MOUSE
θ value	1.25267e-09 (rank : 662)	NC score	0.784993 (rank : 438)
Query Neighborhood Hits	1931	Target Neighborhood Hits	770	Shared Neighborhood Hits	764
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

ERBB4_HUMAN
θ value	1.25267e-09 (rank : 663)	NC score	0.649039 (rank : 701)
Query Neighborhood Hits	1931	Target Neighborhood Hits	910	Shared Neighborhood Hits	817
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

MAG_MOUSE
θ value	1.25267e-09 (rank : 664)	NC score	0.365082 (rank : 918)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	256
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MLTK_MOUSE
θ value	1.25267e-09 (rank : 665)	NC score	0.750446 (rank : 535)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	822
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

ARHG4_HUMAN
θ value	1.63604e-09 (rank : 666)	NC score	0.123774 (rank : 1114)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BMP2K_MOUSE
θ value	1.63604e-09 (rank : 667)	NC score	0.771727 (rank : 483)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	784
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

FAK1_HUMAN
θ value	1.63604e-09 (rank : 668)	NC score	0.685096 (rank : 624)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FES_MOUSE
θ value	1.63604e-09 (rank : 669)	NC score	0.701842 (rank : 599)
Query Neighborhood Hits	1931	Target Neighborhood Hits	980	Shared Neighborhood Hits	816
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

STK35_HUMAN
θ value	1.63604e-09 (rank : 670)	NC score	0.812437 (rank : 311)
Query Neighborhood Hits	1931	Target Neighborhood Hits	825	Shared Neighborhood Hits	813
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

TESK1_HUMAN
θ value	1.63604e-09 (rank : 671)	NC score	0.766009 (rank : 501)
Query Neighborhood Hits	1931	Target Neighborhood Hits	864	Shared Neighborhood Hits	822
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

FSTL5_HUMAN
θ value	2.13673e-09 (rank : 672)	NC score	0.339890 (rank : 935)
Query Neighborhood Hits	1931	Target Neighborhood Hits	347	Shared Neighborhood Hits	264
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

FSTL5_MOUSE
θ value	2.13673e-09 (rank : 673)	NC score	0.336342 (rank : 937)
Query Neighborhood Hits	1931	Target Neighborhood Hits	355	Shared Neighborhood Hits	261
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

JAK2_HUMAN
θ value	2.13673e-09 (rank : 674)	NC score	0.718914 (rank : 575)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	828
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

LYN_MOUSE
θ value	2.13673e-09 (rank : 675)	NC score	0.674277 (rank : 648)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1023	Shared Neighborhood Hits	857
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SRC_HUMAN
θ value	2.13673e-09 (rank : 676)	NC score	0.653576 (rank : 695)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1058	Shared Neighborhood Hits	847
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TEC_HUMAN
θ value	2.13673e-09 (rank : 677)	NC score	0.682311 (rank : 629)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1006	Shared Neighborhood Hits	839
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TRIB3_MOUSE
θ value	2.13673e-09 (rank : 678)	NC score	0.720152 (rank : 571)
Query Neighborhood Hits	1931	Target Neighborhood Hits	578	Shared Neighborhood Hits	575
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

ABL1_HUMAN
θ value	2.79066e-09 (rank : 679)	NC score	0.679074 (rank : 633)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1220	Shared Neighborhood Hits	908
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CD2L1_MOUSE
θ value	2.79066e-09 (rank : 680)	NC score	0.764197 (rank : 504)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1463	Shared Neighborhood Hits	868
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L5_HUMAN
θ value	2.79066e-09 (rank : 681)	NC score	0.785053 (rank : 437)
Query Neighborhood Hits	1931	Target Neighborhood Hits	987	Shared Neighborhood Hits	853
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	2.79066e-09 (rank : 682)	NC score	0.784817 (rank : 439)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1011	Shared Neighborhood Hits	851
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

FGD4_MOUSE
θ value	2.79066e-09 (rank : 683)	NC score	0.102739 (rank : 1159)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGR_MOUSE
θ value	2.79066e-09 (rank : 684)	NC score	0.640921 (rank : 719)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1069	Shared Neighborhood Hits	849
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ACK1_HUMAN
θ value	3.64472e-09 (rank : 685)	NC score	0.656145 (rank : 683)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1140	Shared Neighborhood Hits	925
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

JAK3_HUMAN
θ value	3.64472e-09 (rank : 686)	NC score	0.712772 (rank : 583)
Query Neighborhood Hits	1931	Target Neighborhood Hits	827	Shared Neighborhood Hits	816
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

PDK1L_HUMAN
θ value	3.64472e-09 (rank : 687)	NC score	0.816115 (rank : 283)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	811
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

STK40_HUMAN
θ value	3.64472e-09 (rank : 688)	NC score	0.796557 (rank : 377)
Query Neighborhood Hits	1931	Target Neighborhood Hits	751	Shared Neighborhood Hits	746
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	3.64472e-09 (rank : 689)	NC score	0.796304 (rank : 380)
Query Neighborhood Hits	1931	Target Neighborhood Hits	751	Shared Neighborhood Hits	745
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

TRIB2_MOUSE
θ value	3.64472e-09 (rank : 690)	NC score	0.757956 (rank : 517)
Query Neighborhood Hits	1931	Target Neighborhood Hits	653	Shared Neighborhood Hits	650
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB3_HUMAN
θ value	3.64472e-09 (rank : 691)	NC score	0.700217 (rank : 604)
Query Neighborhood Hits	1931	Target Neighborhood Hits	519	Shared Neighborhood Hits	517
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

BASI_HUMAN
θ value	4.76016e-09 (rank : 692)	NC score	0.306454 (rank : 969)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	201
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

CD2L7_HUMAN
θ value	4.76016e-09 (rank : 693)	NC score	0.786873 (rank : 431)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1275	Shared Neighborhood Hits	925
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

E2AK3_HUMAN
θ value	4.76016e-09 (rank : 694)	NC score	0.792244 (rank : 404)
Query Neighborhood Hits	1931	Target Neighborhood Hits	859	Shared Neighborhood Hits	828
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	4.76016e-09 (rank : 695)	NC score	0.790119 (rank : 412)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	832
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

F5006_MOUSE
θ value	4.76016e-09 (rank : 696)	NC score	0.804899 (rank : 344)
Query Neighborhood Hits	1931	Target Neighborhood Hits	793	Shared Neighborhood Hits	790
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

JAK2_MOUSE
θ value	4.76016e-09 (rank : 697)	NC score	0.717739 (rank : 576)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	823
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

LIMK1_MOUSE
θ value	4.76016e-09 (rank : 698)	NC score	0.733634 (rank : 560)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1008	Shared Neighborhood Hits	826
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LYN_HUMAN
θ value	4.76016e-09 (rank : 699)	NC score	0.673418 (rank : 651)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1022	Shared Neighborhood Hits	858
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

TEC_MOUSE
θ value	4.76016e-09 (rank : 700)	NC score	0.686977 (rank : 620)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1006	Shared Neighborhood Hits	837
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TRIB2_HUMAN
θ value	4.76016e-09 (rank : 701)	NC score	0.758347 (rank : 515)
Query Neighborhood Hits	1931	Target Neighborhood Hits	657	Shared Neighborhood Hits	654
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

FAK1_MOUSE
θ value	6.21693e-09 (rank : 702)	NC score	0.684460 (rank : 627)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	819
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

PDK1L_MOUSE
θ value	6.21693e-09 (rank : 703)	NC score	0.815930 (rank : 287)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	812
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

SRC_MOUSE
θ value	6.21693e-09 (rank : 704)	NC score	0.653904 (rank : 694)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1033	Shared Neighborhood Hits	844
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FGD2_HUMAN
θ value	8.11959e-09 (rank : 705)	NC score	0.104199 (rank : 1155)
Query Neighborhood Hits	1931	Target Neighborhood Hits	151	Shared Neighborhood Hits	60
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ICAM5_MOUSE
θ value	8.11959e-09 (rank : 706)	NC score	0.332969 (rank : 942)
Query Neighborhood Hits	1931	Target Neighborhood Hits	308	Shared Neighborhood Hits	256
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

KAZD1_MOUSE
θ value	8.11959e-09 (rank : 707)	NC score	0.305501 (rank : 972)
Query Neighborhood Hits	1931	Target Neighborhood Hits	281	Shared Neighborhood Hits	206
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

LIMK2_MOUSE
θ value	8.11959e-09 (rank : 708)	NC score	0.734558 (rank : 556)
Query Neighborhood Hits	1931	Target Neighborhood Hits	998	Shared Neighborhood Hits	821
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

ROR2_MOUSE
θ value	8.11959e-09 (rank : 709)	NC score	0.665218 (rank : 662)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1000	Shared Neighborhood Hits	946
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

VCAM1_HUMAN
θ value	8.11959e-09 (rank : 710)	NC score	0.374335 (rank : 913)
Query Neighborhood Hits	1931	Target Neighborhood Hits	352	Shared Neighborhood Hits	284
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

BMP2K_HUMAN
θ value	1.06045e-08 (rank : 711)	NC score	0.770792 (rank : 485)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	784
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CD2L1_HUMAN
θ value	1.06045e-08 (rank : 712)	NC score	0.764422 (rank : 503)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1467	Shared Neighborhood Hits	870
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L2_HUMAN
θ value	1.06045e-08 (rank : 713)	NC score	0.767462 (rank : 497)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1439	Shared Neighborhood Hits	872
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

FER_HUMAN
θ value	1.38499e-08 (rank : 714)	NC score	0.683356 (rank : 628)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1278	Shared Neighborhood Hits	830
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

IGS4B_HUMAN
θ value	1.38499e-08 (rank : 715)	NC score	0.312089 (rank : 965)
Query Neighborhood Hits	1931	Target Neighborhood Hits	305	Shared Neighborhood Hits	262
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

RIPK1_MOUSE
θ value	1.38499e-08 (rank : 716)	NC score	0.755754 (rank : 524)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	832
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TYK2_MOUSE
θ value	1.38499e-08 (rank : 717)	NC score	0.706456 (rank : 595)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	833
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

VAV_HUMAN
θ value	1.38499e-08 (rank : 718)	NC score	0.141022 (rank : 1089)
Query Neighborhood Hits	1931	Target Neighborhood Hits	452	Shared Neighborhood Hits	150
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CEAM1_HUMAN
θ value	1.80886e-08 (rank : 719)	NC score	0.297262 (rank : 981)
Query Neighborhood Hits	1931	Target Neighborhood Hits	348	Shared Neighborhood Hits	274
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

EPHA1_HUMAN
θ value	1.80886e-08 (rank : 720)	NC score	0.636491 (rank : 725)
Query Neighborhood Hits	1931	Target Neighborhood Hits	997	Shared Neighborhood Hits	862
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

ERBB3_HUMAN
θ value	1.80886e-08 (rank : 721)	NC score	0.610477 (rank : 762)
Query Neighborhood Hits	1931	Target Neighborhood Hits	918	Shared Neighborhood Hits	788
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

LU_HUMAN
θ value	1.80886e-08 (rank : 722)	NC score	0.351064 (rank : 925)
Query Neighborhood Hits	1931	Target Neighborhood Hits	283	Shared Neighborhood Hits	260
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

PRP4B_HUMAN
θ value	1.80886e-08 (rank : 723)	NC score	0.744819 (rank : 542)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1030	Shared Neighborhood Hits	785
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	1.80886e-08 (rank : 724)	NC score	0.743137 (rank : 544)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1040	Shared Neighborhood Hits	787
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

ABL2_HUMAN
θ value	2.36244e-08 (rank : 725)	NC score	0.675213 (rank : 644)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1045	Shared Neighborhood Hits	850
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

DDR2_MOUSE
θ value	2.36244e-08 (rank : 726)	NC score	0.629217 (rank : 739)
Query Neighborhood Hits	1931	Target Neighborhood Hits	813	Shared Neighborhood Hits	779
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FGD2_MOUSE
θ value	2.36244e-08 (rank : 727)	NC score	0.102463 (rank : 1162)
Query Neighborhood Hits	1931	Target Neighborhood Hits	163	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD5_MOUSE
θ value	2.36244e-08 (rank : 728)	NC score	0.082842 (rank : 1214)
Query Neighborhood Hits	1931	Target Neighborhood Hits	170	Shared Neighborhood Hits	44
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

ITK_HUMAN
θ value	2.36244e-08 (rank : 729)	NC score	0.676256 (rank : 641)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1016	Shared Neighborhood Hits	846
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

JAM1_HUMAN
θ value	2.36244e-08 (rank : 730)	NC score	0.343625 (rank : 933)
Query Neighborhood Hits	1931	Target Neighborhood Hits	294	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

LCK_MOUSE
θ value	2.36244e-08 (rank : 731)	NC score	0.665014 (rank : 663)
Query Neighborhood Hits	1931	Target Neighborhood Hits	981	Shared Neighborhood Hits	837
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

RET_HUMAN
θ value	2.36244e-08 (rank : 732)	NC score	0.656613 (rank : 682)
Query Neighborhood Hits	1931	Target Neighborhood Hits	873	Shared Neighborhood Hits	804
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ROR2_HUMAN
θ value	2.36244e-08 (rank : 733)	NC score	0.685302 (rank : 623)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1014	Shared Neighborhood Hits	965
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ATL3_HUMAN
θ value	3.08544e-08 (rank : 734)	NC score	0.229619 (rank : 1014)
Query Neighborhood Hits	1931	Target Neighborhood Hits	414	Shared Neighborhood Hits	278
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

CSK_MOUSE
θ value	3.08544e-08 (rank : 735)	NC score	0.684652 (rank : 626)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	846
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

HCK_HUMAN
θ value	3.08544e-08 (rank : 736)	NC score	0.659171 (rank : 676)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1035	Shared Neighborhood Hits	848
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

IGS4B_MOUSE
θ value	3.08544e-08 (rank : 737)	NC score	0.319077 (rank : 959)
Query Neighborhood Hits	1931	Target Neighborhood Hits	328	Shared Neighborhood Hits	280
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

KIRR1_HUMAN
θ value	3.08544e-08 (rank : 738)	NC score	0.331885 (rank : 945)
Query Neighborhood Hits	1931	Target Neighborhood Hits	401	Shared Neighborhood Hits	302
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

KSYK_HUMAN
θ value	3.08544e-08 (rank : 739)	NC score	0.687610 (rank : 619)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	819
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LIMK2_HUMAN
θ value	3.08544e-08 (rank : 740)	NC score	0.737181 (rank : 551)
Query Neighborhood Hits	1931	Target Neighborhood Hits	986	Shared Neighborhood Hits	819
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MATK_HUMAN
θ value	3.08544e-08 (rank : 741)	NC score	0.672389 (rank : 652)
Query Neighborhood Hits	1931	Target Neighborhood Hits	954	Shared Neighborhood Hits	835
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	3.08544e-08 (rank : 742)	NC score	0.676143 (rank : 642)
Query Neighborhood Hits	1931	Target Neighborhood Hits	952	Shared Neighborhood Hits	835
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

AAK1_MOUSE
θ value	4.0297e-08 (rank : 743)	NC score	0.768681 (rank : 491)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1051	Shared Neighborhood Hits	875
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

KIRR1_MOUSE
θ value	4.0297e-08 (rank : 744)	NC score	0.328811 (rank : 948)
Query Neighborhood Hits	1931	Target Neighborhood Hits	403	Shared Neighborhood Hits	299
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

ARHG7_MOUSE
θ value	5.26297e-08 (rank : 745)	NC score	0.111994 (rank : 1136)
Query Neighborhood Hits	1931	Target Neighborhood Hits	396	Shared Neighborhood Hits	106
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CLK2_HUMAN
θ value	5.26297e-08 (rank : 746)	NC score	0.733039 (rank : 561)
Query Neighborhood Hits	1931	Target Neighborhood Hits	752	Shared Neighborhood Hits	736
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

CSK_HUMAN
θ value	5.26297e-08 (rank : 747)	NC score	0.677312 (rank : 638)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	845
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

EGFR_MOUSE
θ value	5.26297e-08 (rank : 748)	NC score	0.648110 (rank : 705)
Query Neighborhood Hits	1931	Target Neighborhood Hits	927	Shared Neighborhood Hits	827
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

FSTL4_HUMAN
θ value	5.26297e-08 (rank : 749)	NC score	0.343970 (rank : 931)
Query Neighborhood Hits	1931	Target Neighborhood Hits	344	Shared Neighborhood Hits	270
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

HCK_MOUSE
θ value	5.26297e-08 (rank : 750)	NC score	0.655090 (rank : 688)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1029	Shared Neighborhood Hits	848
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

KSYK_MOUSE
θ value	5.26297e-08 (rank : 751)	NC score	0.687652 (rank : 618)
Query Neighborhood Hits	1931	Target Neighborhood Hits	944	Shared Neighborhood Hits	840
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

YES_MOUSE
θ value	5.26297e-08 (rank : 752)	NC score	0.648926 (rank : 702)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1052	Shared Neighborhood Hits	844
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHG4_MOUSE
θ value	6.87365e-08 (rank : 753)	NC score	0.118582 (rank : 1125)
Query Neighborhood Hits	1931	Target Neighborhood Hits	185	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PSG8_HUMAN
θ value	6.87365e-08 (rank : 754)	NC score	0.233283 (rank : 1010)
Query Neighborhood Hits	1931	Target Neighborhood Hits	239	Shared Neighborhood Hits	218
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

RET_MOUSE
θ value	6.87365e-08 (rank : 755)	NC score	0.655275 (rank : 687)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	806
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ROR1_MOUSE
θ value	6.87365e-08 (rank : 756)	NC score	0.698379 (rank : 608)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1025	Shared Neighborhood Hits	987
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

YES_HUMAN
θ value	6.87365e-08 (rank : 757)	NC score	0.649499 (rank : 698)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1059	Shared Neighborhood Hits	847
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ACK1_MOUSE
θ value	8.97725e-08 (rank : 758)	NC score	0.654435 (rank : 690)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1080	Shared Neighborhood Hits	899
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ERBB2_HUMAN
θ value	8.97725e-08 (rank : 759)	NC score	0.636966 (rank : 724)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1073	Shared Neighborhood Hits	879
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ICAM5_HUMAN
θ value	8.97725e-08 (rank : 760)	NC score	0.320278 (rank : 957)
Query Neighborhood Hits	1931	Target Neighborhood Hits	276	Shared Neighborhood Hits	245
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

KIRR3_MOUSE
θ value	8.97725e-08 (rank : 761)	NC score	0.332085 (rank : 944)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	256
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

RON_HUMAN
θ value	8.97725e-08 (rank : 762)	NC score	0.637978 (rank : 723)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	807
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

TNK1_MOUSE
θ value	8.97725e-08 (rank : 763)	NC score	0.667632 (rank : 659)
Query Neighborhood Hits	1931	Target Neighborhood Hits	806	Shared Neighborhood Hits	786
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

FGR_HUMAN
θ value	1.17247e-07 (rank : 764)	NC score	0.644185 (rank : 713)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1067	Shared Neighborhood Hits	848
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

PSG4_HUMAN
θ value	1.17247e-07 (rank : 765)	NC score	0.231268 (rank : 1012)
Query Neighborhood Hits	1931	Target Neighborhood Hits	243	Shared Neighborhood Hits	222
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

VGFR3_HUMAN
θ value	1.17247e-07 (rank : 766)	NC score	0.686883 (rank : 621)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1037	Shared Neighborhood Hits	1014
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

ZAP70_MOUSE
θ value	1.17247e-07 (rank : 767)	NC score	0.684689 (rank : 625)
Query Neighborhood Hits	1931	Target Neighborhood Hits	905	Shared Neighborhood Hits	827
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

AAK1_HUMAN
θ value	1.53129e-07 (rank : 768)	NC score	0.768377 (rank : 493)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1077	Shared Neighborhood Hits	881
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

BLK_HUMAN
θ value	1.53129e-07 (rank : 769)	NC score	0.659571 (rank : 675)
Query Neighborhood Hits	1931	Target Neighborhood Hits	994	Shared Neighborhood Hits	842
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CLK1_HUMAN
θ value	1.53129e-07 (rank : 770)	NC score	0.742845 (rank : 545)
Query Neighborhood Hits	1931	Target Neighborhood Hits	756	Shared Neighborhood Hits	742
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

RIPK5_HUMAN
θ value	1.53129e-07 (rank : 771)	NC score	0.771273 (rank : 484)
Query Neighborhood Hits	1931	Target Neighborhood Hits	864	Shared Neighborhood Hits	838
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

ZAP70_HUMAN
θ value	1.53129e-07 (rank : 772)	NC score	0.686721 (rank : 622)
Query Neighborhood Hits	1931	Target Neighborhood Hits	893	Shared Neighborhood Hits	823
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

BASI_MOUSE
θ value	1.99992e-07 (rank : 773)	NC score	0.299632 (rank : 979)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	223
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

E2AK2_HUMAN
θ value	1.99992e-07 (rank : 774)	NC score	0.810921 (rank : 323)
Query Neighborhood Hits	1931	Target Neighborhood Hits	856	Shared Neighborhood Hits	825
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

EPHA7_HUMAN
θ value	1.99992e-07 (rank : 775)	NC score	0.660460 (rank : 671)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1053	Shared Neighborhood Hits	902
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	1.99992e-07 (rank : 776)	NC score	0.660494 (rank : 670)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1025	Shared Neighborhood Hits	899
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

ERBB2_MOUSE
θ value	1.99992e-07 (rank : 777)	NC score	0.639041 (rank : 720)
Query Neighborhood Hits	1931	Target Neighborhood Hits	918	Shared Neighborhood Hits	824
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_MOUSE
θ value	1.99992e-07 (rank : 778)	NC score	0.613019 (rank : 760)
Query Neighborhood Hits	1931	Target Neighborhood Hits	898	Shared Neighborhood Hits	787
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

JAM1_MOUSE
θ value	1.99992e-07 (rank : 779)	NC score	0.330546 (rank : 946)
Query Neighborhood Hits	1931	Target Neighborhood Hits	287	Shared Neighborhood Hits	255
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

RIPK5_MOUSE
θ value	1.99992e-07 (rank : 780)	NC score	0.770724 (rank : 486)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	839
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

EGFR_HUMAN
θ value	2.61198e-07 (rank : 781)	NC score	0.647467 (rank : 707)
Query Neighborhood Hits	1931	Target Neighborhood Hits	939	Shared Neighborhood Hits	820
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

INSR_MOUSE
θ value	2.61198e-07 (rank : 782)	NC score	0.633142 (rank : 731)
Query Neighborhood Hits	1931	Target Neighborhood Hits	968	Shared Neighborhood Hits	846
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KIRR3_HUMAN
θ value	2.61198e-07 (rank : 783)	NC score	0.334532 (rank : 940)
Query Neighborhood Hits	1931	Target Neighborhood Hits	302	Shared Neighborhood Hits	265
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

LRFN2_MOUSE
θ value	2.61198e-07 (rank : 784)	NC score	0.201757 (rank : 1033)
Query Neighborhood Hits	1931	Target Neighborhood Hits	450	Shared Neighborhood Hits	229
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN4_HUMAN
θ value	2.61198e-07 (rank : 785)	NC score	0.206661 (rank : 1025)
Query Neighborhood Hits	1931	Target Neighborhood Hits	462	Shared Neighborhood Hits	234
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

RIPK1_HUMAN
θ value	2.61198e-07 (rank : 786)	NC score	0.762056 (rank : 506)
Query Neighborhood Hits	1931	Target Neighborhood Hits	891	Shared Neighborhood Hits	841
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TNK1_HUMAN
θ value	2.61198e-07 (rank : 787)	NC score	0.658674 (rank : 678)
Query Neighborhood Hits	1931	Target Neighborhood Hits	815	Shared Neighborhood Hits	788
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

CLK1_MOUSE
θ value	3.41135e-07 (rank : 788)	NC score	0.742023 (rank : 546)
Query Neighborhood Hits	1931	Target Neighborhood Hits	760	Shared Neighborhood Hits	749
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

DDR2_HUMAN
θ value	3.41135e-07 (rank : 789)	NC score	0.623566 (rank : 746)
Query Neighborhood Hits	1931	Target Neighborhood Hits	818	Shared Neighborhood Hits	779
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

E2AK4_HUMAN
θ value	3.41135e-07 (rank : 790)	NC score	0.776779 (rank : 466)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1012	Shared Neighborhood Hits	845
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

EPHA1_MOUSE
θ value	3.41135e-07 (rank : 791)	NC score	0.627567 (rank : 741)
Query Neighborhood Hits	1931	Target Neighborhood Hits	958	Shared Neighborhood Hits	854
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHB1_HUMAN
θ value	3.41135e-07 (rank : 792)	NC score	0.661890 (rank : 668)
Query Neighborhood Hits	1931	Target Neighborhood Hits	988	Shared Neighborhood Hits	887
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

FSTL4_MOUSE
θ value	3.41135e-07 (rank : 793)	NC score	0.336539 (rank : 936)
Query Neighborhood Hits	1931	Target Neighborhood Hits	333	Shared Neighborhood Hits	261
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

GPA33_HUMAN
θ value	3.41135e-07 (rank : 794)	NC score	0.253437 (rank : 1001)
Query Neighborhood Hits	1931	Target Neighborhood Hits	273	Shared Neighborhood Hits	213
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

INSR_HUMAN
θ value	3.41135e-07 (rank : 795)	NC score	0.633622 (rank : 730)
Query Neighborhood Hits	1931	Target Neighborhood Hits	963	Shared Neighborhood Hits	853
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KAZD1_HUMAN
θ value	3.41135e-07 (rank : 796)	NC score	0.278757 (rank : 991)
Query Neighborhood Hits	1931	Target Neighborhood Hits	248	Shared Neighborhood Hits	173
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

ROR1_HUMAN
θ value	3.41135e-07 (rank : 797)	NC score	0.696909 (rank : 611)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1018	Shared Neighborhood Hits	980
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

VCAM1_MOUSE
θ value	3.41135e-07 (rank : 798)	NC score	0.373777 (rank : 914)
Query Neighborhood Hits	1931	Target Neighborhood Hits	320	Shared Neighborhood Hits	274
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

FAK2_MOUSE
θ value	4.45536e-07 (rank : 799)	NC score	0.673444 (rank : 650)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	807
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

LRFN2_HUMAN
θ value	4.45536e-07 (rank : 800)	NC score	0.202429 (rank : 1032)
Query Neighborhood Hits	1931	Target Neighborhood Hits	450	Shared Neighborhood Hits	224
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

HIPK4_HUMAN
θ value	5.81887e-07 (rank : 801)	NC score	0.778716 (rank : 461)
Query Neighborhood Hits	1931	Target Neighborhood Hits	799	Shared Neighborhood Hits	784
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

IGF1R_HUMAN
θ value	5.81887e-07 (rank : 802)	NC score	0.615797 (rank : 759)
Query Neighborhood Hits	1931	Target Neighborhood Hits	977	Shared Neighborhood Hits	843
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

BLK_MOUSE
θ value	7.59969e-07 (rank : 803)	NC score	0.657990 (rank : 680)
Query Neighborhood Hits	1931	Target Neighborhood Hits	992	Shared Neighborhood Hits	842
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FYN_MOUSE
θ value	7.59969e-07 (rank : 804)	NC score	0.653964 (rank : 693)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1073	Shared Neighborhood Hits	854
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

LCK_HUMAN
θ value	7.59969e-07 (rank : 805)	NC score	0.659834 (rank : 673)
Query Neighborhood Hits	1931	Target Neighborhood Hits	987	Shared Neighborhood Hits	841
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

NTRK2_HUMAN
θ value	7.59969e-07 (rank : 806)	NC score	0.716884 (rank : 579)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1081	Shared Neighborhood Hits	983
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	7.59969e-07 (rank : 807)	NC score	0.717224 (rank : 578)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1088	Shared Neighborhood Hits	981
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

PGFRA_HUMAN
θ value	7.59969e-07 (rank : 808)	NC score	0.657254 (rank : 681)
Query Neighborhood Hits	1931	Target Neighborhood Hits	980	Shared Neighborhood Hits	950
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	7.59969e-07 (rank : 809)	NC score	0.654964 (rank : 689)
Query Neighborhood Hits	1931	Target Neighborhood Hits	975	Shared Neighborhood Hits	952
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

FAK2_HUMAN
θ value	9.92553e-07 (rank : 810)	NC score	0.668713 (rank : 657)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	802
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

IGF1R_MOUSE
θ value	9.92553e-07 (rank : 811)	NC score	0.617542 (rank : 756)
Query Neighborhood Hits	1931	Target Neighborhood Hits	973	Shared Neighborhood Hits	842
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

NPTN_MOUSE
θ value	9.92553e-07 (rank : 812)	NC score	0.332231 (rank : 943)
Query Neighborhood Hits	1931	Target Neighborhood Hits	216	Shared Neighborhood Hits	208
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

RAGE_HUMAN
θ value	9.92553e-07 (rank : 813)	NC score	0.346837 (rank : 928)
Query Neighborhood Hits	1931	Target Neighborhood Hits	269	Shared Neighborhood Hits	252
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

CLK2_MOUSE
θ value	1.29631e-06 (rank : 814)	NC score	0.721165 (rank : 569)
Query Neighborhood Hits	1931	Target Neighborhood Hits	743	Shared Neighborhood Hits	730
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

EPHB4_MOUSE
θ value	1.29631e-06 (rank : 815)	NC score	0.655524 (rank : 686)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1013	Shared Neighborhood Hits	891
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

KSR2_HUMAN
θ value	1.29631e-06 (rank : 816)	NC score	0.734519 (rank : 557)
Query Neighborhood Hits	1931	Target Neighborhood Hits	920	Shared Neighborhood Hits	839
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

PSG3_HUMAN
θ value	1.29631e-06 (rank : 817)	NC score	0.232687 (rank : 1011)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	222
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

PSG7_HUMAN
θ value	1.29631e-06 (rank : 818)	NC score	0.225874 (rank : 1015)
Query Neighborhood Hits	1931	Target Neighborhood Hits	239	Shared Neighborhood Hits	218
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

PSG9_HUMAN
θ value	1.29631e-06 (rank : 819)	NC score	0.212353 (rank : 1022)
Query Neighborhood Hits	1931	Target Neighborhood Hits	221	Shared Neighborhood Hits	207
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

TOPK_HUMAN
θ value	1.29631e-06 (rank : 820)	NC score	0.582364 (rank : 787)
Query Neighborhood Hits	1931	Target Neighborhood Hits	605	Shared Neighborhood Hits	596
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

ARHG7_HUMAN
θ value	1.69304e-06 (rank : 821)	NC score	0.111217 (rank : 1138)
Query Neighborhood Hits	1931	Target Neighborhood Hits	347	Shared Neighborhood Hits	103
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CI096_HUMAN
θ value	1.69304e-06 (rank : 822)	NC score	0.781967 (rank : 450)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	799
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

E2AK4_MOUSE
θ value	1.69304e-06 (rank : 823)	NC score	0.773330 (rank : 475)
Query Neighborhood Hits	1931	Target Neighborhood Hits	984	Shared Neighborhood Hits	842
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

EPHA8_MOUSE
θ value	1.69304e-06 (rank : 824)	NC score	0.646267 (rank : 711)
Query Neighborhood Hits	1931	Target Neighborhood Hits	969	Shared Neighborhood Hits	890
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

FGD5_HUMAN
θ value	1.69304e-06 (rank : 825)	NC score	0.082596 (rank : 1217)
Query Neighborhood Hits	1931	Target Neighborhood Hits	235	Shared Neighborhood Hits	53
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FYN_HUMAN
θ value	1.69304e-06 (rank : 826)	NC score	0.658362 (rank : 679)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1078	Shared Neighborhood Hits	852
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

LRFN3_HUMAN
θ value	1.69304e-06 (rank : 827)	NC score	0.193134 (rank : 1037)
Query Neighborhood Hits	1931	Target Neighborhood Hits	444	Shared Neighborhood Hits	217
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

LRFN4_MOUSE
θ value	1.69304e-06 (rank : 828)	NC score	0.203591 (rank : 1028)
Query Neighborhood Hits	1931	Target Neighborhood Hits	442	Shared Neighborhood Hits	226
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRFN5_MOUSE
θ value	1.69304e-06 (rank : 829)	NC score	0.191220 (rank : 1040)
Query Neighborhood Hits	1931	Target Neighborhood Hits	472	Shared Neighborhood Hits	236
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

PIGR_HUMAN
θ value	1.69304e-06 (rank : 830)	NC score	0.158393 (rank : 1069)
Query Neighborhood Hits	1931	Target Neighborhood Hits	164	Shared Neighborhood Hits	125
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PINK1_HUMAN
θ value	1.69304e-06 (rank : 831)	NC score	0.709086 (rank : 590)
Query Neighborhood Hits	1931	Target Neighborhood Hits	741	Shared Neighborhood Hits	729
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

CLK4_MOUSE
θ value	2.21117e-06 (rank : 832)	NC score	0.735898 (rank : 554)
Query Neighborhood Hits	1931	Target Neighborhood Hits	759	Shared Neighborhood Hits	751
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

GUC2D_HUMAN
θ value	2.21117e-06 (rank : 833)	NC score	0.463431 (rank : 820)
Query Neighborhood Hits	1931	Target Neighborhood Hits	715	Shared Neighborhood Hits	664
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

JAK3_MOUSE
θ value	2.21117e-06 (rank : 834)	NC score	0.717314 (rank : 577)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	811
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

LRRN5_HUMAN
θ value	2.21117e-06 (rank : 835)	NC score	0.162303 (rank : 1062)
Query Neighborhood Hits	1931	Target Neighborhood Hits	493	Shared Neighborhood Hits	246
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

PGFRB_MOUSE
θ value	2.21117e-06 (rank : 836)	NC score	0.646326 (rank : 710)
Query Neighborhood Hits	1931	Target Neighborhood Hits	960	Shared Neighborhood Hits	938
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

RON_MOUSE
θ value	2.21117e-06 (rank : 837)	NC score	0.627036 (rank : 742)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	799
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

SIG11_HUMAN
θ value	2.21117e-06 (rank : 838)	NC score	0.305817 (rank : 970)
Query Neighborhood Hits	1931	Target Neighborhood Hits	273	Shared Neighborhood Hits	251
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

EPHB2_HUMAN
θ value	2.88788e-06 (rank : 839)	NC score	0.646690 (rank : 709)
Query Neighborhood Hits	1931	Target Neighborhood Hits	983	Shared Neighborhood Hits	880
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	2.88788e-06 (rank : 840)	NC score	0.646890 (rank : 708)
Query Neighborhood Hits	1931	Target Neighborhood Hits	982	Shared Neighborhood Hits	880
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB4_HUMAN
θ value	2.88788e-06 (rank : 841)	NC score	0.651641 (rank : 697)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1056	Shared Neighborhood Hits	896
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

FNDC3_MOUSE
θ value	2.88788e-06 (rank : 842)	NC score	0.253210 (rank : 1002)
Query Neighborhood Hits	1931	Target Neighborhood Hits	207	Shared Neighborhood Hits	145
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

GUC2E_MOUSE
θ value	2.88788e-06 (rank : 843)	NC score	0.442156 (rank : 829)
Query Neighborhood Hits	1931	Target Neighborhood Hits	692	Shared Neighborhood Hits	640
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

INSRR_MOUSE
θ value	2.88788e-06 (rank : 844)	NC score	0.619485 (rank : 752)
Query Neighborhood Hits	1931	Target Neighborhood Hits	961	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PSG1_HUMAN
θ value	2.88788e-06 (rank : 845)	NC score	0.220690 (rank : 1017)
Query Neighborhood Hits	1931	Target Neighborhood Hits	232	Shared Neighborhood Hits	213
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

LRFN5_HUMAN
θ value	3.77169e-06 (rank : 846)	NC score	0.187124 (rank : 1043)
Query Neighborhood Hits	1931	Target Neighborhood Hits	464	Shared Neighborhood Hits	231
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

TIAM1_MOUSE
θ value	3.77169e-06 (rank : 847)	NC score	0.102782 (rank : 1158)
Query Neighborhood Hits	1931	Target Neighborhood Hits	205	Shared Neighborhood Hits	71
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIE2_HUMAN
θ value	3.77169e-06 (rank : 848)	NC score	0.677334 (rank : 637)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1192	Shared Neighborhood Hits	913
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	3.77169e-06 (rank : 849)	NC score	0.676597 (rank : 639)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1204	Shared Neighborhood Hits	910
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TYRO3_HUMAN
θ value	3.77169e-06 (rank : 850)	NC score	0.701232 (rank : 601)
Query Neighborhood Hits	1931	Target Neighborhood Hits	995	Shared Neighborhood Hits	964
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

AL2S2_MOUSE
θ value	4.92598e-06 (rank : 851)	NC score	0.708241 (rank : 592)
Query Neighborhood Hits	1931	Target Neighborhood Hits	709	Shared Neighborhood Hits	695
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

EPHB3_HUMAN
θ value	4.92598e-06 (rank : 852)	NC score	0.642451 (rank : 716)
Query Neighborhood Hits	1931	Target Neighborhood Hits	996	Shared Neighborhood Hits	897
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	4.92598e-06 (rank : 853)	NC score	0.641582 (rank : 717)
Query Neighborhood Hits	1931	Target Neighborhood Hits	996	Shared Neighborhood Hits	896
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

FGD6_MOUSE
θ value	4.92598e-06 (rank : 854)	NC score	0.091684 (rank : 1190)
Query Neighborhood Hits	1931	Target Neighborhood Hits	282	Shared Neighborhood Hits	89
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

LRC21_HUMAN
θ value	4.92598e-06 (rank : 855)	NC score	0.191194 (rank : 1041)
Query Neighborhood Hits	1931	Target Neighborhood Hits	456	Shared Neighborhood Hits	239
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

NRG2_HUMAN
θ value	4.92598e-06 (rank : 856)	NC score	0.280155 (rank : 990)
Query Neighborhood Hits	1931	Target Neighborhood Hits	419	Shared Neighborhood Hits	262
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

TRIB1_MOUSE
θ value	4.92598e-06 (rank : 857)	NC score	0.730226 (rank : 564)
Query Neighborhood Hits	1931	Target Neighborhood Hits	593	Shared Neighborhood Hits	589
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

AL2S2_HUMAN
θ value	6.43352e-06 (rank : 858)	NC score	0.719983 (rank : 572)
Query Neighborhood Hits	1931	Target Neighborhood Hits	727	Shared Neighborhood Hits	717
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

ARHG8_MOUSE
θ value	6.43352e-06 (rank : 859)	NC score	0.081460 (rank : 1219)
Query Neighborhood Hits	1931	Target Neighborhood Hits	79	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

CI094_HUMAN
θ value	6.43352e-06 (rank : 860)	NC score	0.287296 (rank : 989)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	234
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

CLK4_HUMAN
θ value	6.43352e-06 (rank : 861)	NC score	0.737008 (rank : 552)
Query Neighborhood Hits	1931	Target Neighborhood Hits	759	Shared Neighborhood Hits	752
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

TYRO3_MOUSE
θ value	6.43352e-06 (rank : 862)	NC score	0.699670 (rank : 606)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1007	Shared Neighborhood Hits	973
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

DDR1_MOUSE
θ value	8.40245e-06 (rank : 863)	NC score	0.601145 (rank : 770)
Query Neighborhood Hits	1931	Target Neighborhood Hits	818	Shared Neighborhood Hits	775
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

EPHA4_HUMAN
θ value	8.40245e-06 (rank : 864)	NC score	0.648130 (rank : 704)
Query Neighborhood Hits	1931	Target Neighborhood Hits	975	Shared Neighborhood Hits	889
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	8.40245e-06 (rank : 865)	NC score	0.649077 (rank : 700)
Query Neighborhood Hits	1931	Target Neighborhood Hits	982	Shared Neighborhood Hits	890
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

MET_MOUSE
θ value	8.40245e-06 (rank : 866)	NC score	0.632667 (rank : 732)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	800
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

NRG2_MOUSE
θ value	8.40245e-06 (rank : 867)	NC score	0.273780 (rank : 992)
Query Neighborhood Hits	1931	Target Neighborhood Hits	392	Shared Neighborhood Hits	249
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

PGFRB_HUMAN
θ value	8.40245e-06 (rank : 868)	NC score	0.642454 (rank : 715)
Query Neighborhood Hits	1931	Target Neighborhood Hits	962	Shared Neighborhood Hits	942
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

SCYL2_HUMAN
θ value	8.40245e-06 (rank : 869)	NC score	0.606232 (rank : 767)
Query Neighborhood Hits	1931	Target Neighborhood Hits	632	Shared Neighborhood Hits	569
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

TRIB1_HUMAN
θ value	8.40245e-06 (rank : 870)	NC score	0.731677 (rank : 563)
Query Neighborhood Hits	1931	Target Neighborhood Hits	598	Shared Neighborhood Hits	592
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

VAV_MOUSE
θ value	8.40245e-06 (rank : 871)	NC score	0.135902 (rank : 1099)
Query Neighborhood Hits	1931	Target Neighborhood Hits	430	Shared Neighborhood Hits	147
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

MET_HUMAN
θ value	1.09739e-05 (rank : 872)	NC score	0.630622 (rank : 735)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	796
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

CDC7_MOUSE
θ value	1.43324e-05 (rank : 873)	NC score	0.666341 (rank : 661)
Query Neighborhood Hits	1931	Target Neighborhood Hits	641	Shared Neighborhood Hits	631
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

EPHA2_MOUSE
θ value	1.43324e-05 (rank : 874)	NC score	0.646223 (rank : 712)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1020	Shared Neighborhood Hits	885
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FCRLA_MOUSE
θ value	1.43324e-05 (rank : 875)	NC score	0.106115 (rank : 1151)
Query Neighborhood Hits	1931	Target Neighborhood Hits	110	Shared Neighborhood Hits	79
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FGD6_HUMAN
θ value	1.43324e-05 (rank : 876)	NC score	0.087676 (rank : 1196)
Query Neighborhood Hits	1931	Target Neighborhood Hits	237	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FNDC3_HUMAN
θ value	1.43324e-05 (rank : 877)	NC score	0.250600 (rank : 1004)
Query Neighborhood Hits	1931	Target Neighborhood Hits	196	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

GPA33_MOUSE
θ value	1.43324e-05 (rank : 878)	NC score	0.266285 (rank : 993)
Query Neighborhood Hits	1931	Target Neighborhood Hits	294	Shared Neighborhood Hits	223
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

JAM2_HUMAN
θ value	1.43324e-05 (rank : 879)	NC score	0.328662 (rank : 949)
Query Neighborhood Hits	1931	Target Neighborhood Hits	304	Shared Neighborhood Hits	280
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

RIPK4_HUMAN
θ value	1.43324e-05 (rank : 880)	NC score	0.573541 (rank : 795)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1094	Shared Neighborhood Hits	808
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

UHMK1_HUMAN
θ value	1.43324e-05 (rank : 881)	NC score	0.757920 (rank : 518)
Query Neighborhood Hits	1931	Target Neighborhood Hits	808	Shared Neighborhood Hits	767
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ARHG8_HUMAN
θ value	1.87187e-05 (rank : 882)	NC score	0.085005 (rank : 1205)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

CLK3_HUMAN
θ value	1.87187e-05 (rank : 883)	NC score	0.710946 (rank : 586)
Query Neighborhood Hits	1931	Target Neighborhood Hits	748	Shared Neighborhood Hits	732
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	1.87187e-05 (rank : 884)	NC score	0.710292 (rank : 589)
Query Neighborhood Hits	1931	Target Neighborhood Hits	761	Shared Neighborhood Hits	732
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

EPHA5_HUMAN
θ value	1.87187e-05 (rank : 885)	NC score	0.654073 (rank : 692)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	901
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA8_HUMAN
θ value	1.87187e-05 (rank : 886)	NC score	0.648897 (rank : 703)
Query Neighborhood Hits	1931	Target Neighborhood Hits	956	Shared Neighborhood Hits	891
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

FCRLA_HUMAN
θ value	1.87187e-05 (rank : 887)	NC score	0.103224 (rank : 1157)
Query Neighborhood Hits	1931	Target Neighborhood Hits	135	Shared Neighborhood Hits	82
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

LRC21_MOUSE
θ value	1.87187e-05 (rank : 888)	NC score	0.191561 (rank : 1039)
Query Neighborhood Hits	1931	Target Neighborhood Hits	462	Shared Neighborhood Hits	240
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRC24_MOUSE
θ value	1.87187e-05 (rank : 889)	NC score	0.134025 (rank : 1103)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	195
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

NFH_MOUSE
θ value	1.87187e-05 (rank : 890)	NC score	0.041080 (rank : 1388)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2247	Shared Neighborhood Hits	434
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NPTN_HUMAN
θ value	1.87187e-05 (rank : 891)	NC score	0.328565 (rank : 950)
Query Neighborhood Hits	1931	Target Neighborhood Hits	212	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

SIG10_HUMAN
θ value	1.87187e-05 (rank : 892)	NC score	0.302342 (rank : 975)
Query Neighborhood Hits	1931	Target Neighborhood Hits	363	Shared Neighborhood Hits	277
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

EPHA2_HUMAN
θ value	2.44474e-05 (rank : 893)	NC score	0.649284 (rank : 699)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1021	Shared Neighborhood Hits	888
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA5_MOUSE
θ value	2.44474e-05 (rank : 894)	NC score	0.664993 (rank : 665)
Query Neighborhood Hits	1931	Target Neighborhood Hits	950	Shared Neighborhood Hits	885
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

KSR1_MOUSE
θ value	2.44474e-05 (rank : 895)	NC score	0.707633 (rank : 593)
Query Neighborhood Hits	1931	Target Neighborhood Hits	870	Shared Neighborhood Hits	815
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

LRFN3_MOUSE
θ value	2.44474e-05 (rank : 896)	NC score	0.201105 (rank : 1034)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	231
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

LRRN3_HUMAN
θ value	2.44474e-05 (rank : 897)	NC score	0.171309 (rank : 1052)
Query Neighborhood Hits	1931	Target Neighborhood Hits	461	Shared Neighborhood Hits	231
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

MFA3L_HUMAN
θ value	2.44474e-05 (rank : 898)	NC score	0.290456 (rank : 987)
Query Neighborhood Hits	1931	Target Neighborhood Hits	230	Shared Neighborhood Hits	214
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

UHMK1_MOUSE
θ value	2.44474e-05 (rank : 899)	NC score	0.756488 (rank : 521)
Query Neighborhood Hits	1931	Target Neighborhood Hits	809	Shared Neighborhood Hits	767
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

EPHA3_HUMAN
θ value	3.19293e-05 (rank : 900)	NC score	0.660017 (rank : 672)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1005	Shared Neighborhood Hits	904
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

IRPL2_HUMAN
θ value	3.19293e-05 (rank : 901)	NC score	0.186501 (rank : 1044)
Query Neighborhood Hits	1931	Target Neighborhood Hits	194	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

KIT_HUMAN
θ value	3.19293e-05 (rank : 902)	NC score	0.636419 (rank : 726)
Query Neighborhood Hits	1931	Target Neighborhood Hits	953	Shared Neighborhood Hits	931
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

LRRK1_MOUSE
θ value	3.19293e-05 (rank : 903)	NC score	0.700600 (rank : 603)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1267	Shared Neighborhood Hits	851
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

TMIGD_MOUSE
θ value	3.19293e-05 (rank : 904)	NC score	0.333732 (rank : 941)
Query Neighborhood Hits	1931	Target Neighborhood Hits	234	Shared Neighborhood Hits	229
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

AATK_HUMAN
θ value	4.1701e-05 (rank : 905)	NC score	0.627987 (rank : 740)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1243	Shared Neighborhood Hits	927
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

CDC7_HUMAN
θ value	4.1701e-05 (rank : 906)	NC score	0.669422 (rank : 655)
Query Neighborhood Hits	1931	Target Neighborhood Hits	652	Shared Neighborhood Hits	634
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

KSR1_HUMAN
θ value	4.1701e-05 (rank : 907)	NC score	0.697678 (rank : 610)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	805
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

LRC24_HUMAN
θ value	4.1701e-05 (rank : 908)	NC score	0.146444 (rank : 1082)
Query Neighborhood Hits	1931	Target Neighborhood Hits	404	Shared Neighborhood Hits	198
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

LRRK1_HUMAN
θ value	4.1701e-05 (rank : 909)	NC score	0.702338 (rank : 598)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1237	Shared Neighborhood Hits	846
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

ROS_HUMAN
θ value	4.1701e-05 (rank : 910)	NC score	0.655553 (rank : 685)
Query Neighborhood Hits	1931	Target Neighborhood Hits	907	Shared Neighborhood Hits	844
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

STYK1_MOUSE
θ value	4.1701e-05 (rank : 911)	NC score	0.629219 (rank : 738)
Query Neighborhood Hits	1931	Target Neighborhood Hits	779	Shared Neighborhood Hits	771
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TIAM1_HUMAN
θ value	4.1701e-05 (rank : 912)	NC score	0.099818 (rank : 1166)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TOPK_MOUSE
θ value	4.1701e-05 (rank : 913)	NC score	0.587958 (rank : 782)
Query Neighborhood Hits	1931	Target Neighborhood Hits	618	Shared Neighborhood Hits	608
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

EPHA6_MOUSE
θ value	5.44631e-05 (rank : 914)	NC score	0.597786 (rank : 773)
Query Neighborhood Hits	1931	Target Neighborhood Hits	946	Shared Neighborhood Hits	865
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FLT3_HUMAN
θ value	5.44631e-05 (rank : 915)	NC score	0.598661 (rank : 771)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	834
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	5.44631e-05 (rank : 916)	NC score	0.603436 (rank : 768)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	842
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

GUC2F_HUMAN
θ value	5.44631e-05 (rank : 917)	NC score	0.506456 (rank : 816)
Query Neighborhood Hits	1931	Target Neighborhood Hits	740	Shared Neighborhood Hits	678
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

INSRR_HUMAN
θ value	5.44631e-05 (rank : 918)	NC score	0.615900 (rank : 758)
Query Neighborhood Hits	1931	Target Neighborhood Hits	950	Shared Neighborhood Hits	831
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ANKK1_HUMAN
θ value	7.1131e-05 (rank : 919)	NC score	0.572339 (rank : 796)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1075	Shared Neighborhood Hits	795
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

NGL1_HUMAN
θ value	7.1131e-05 (rank : 920)	NC score	0.136279 (rank : 1097)
Query Neighborhood Hits	1931	Target Neighborhood Hits	511	Shared Neighborhood Hits	240
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_MOUSE
θ value	7.1131e-05 (rank : 921)	NC score	0.136436 (rank : 1096)
Query Neighborhood Hits	1931	Target Neighborhood Hits	512	Shared Neighborhood Hits	241
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NTRK3_HUMAN
θ value	7.1131e-05 (rank : 922)	NC score	0.688436 (rank : 617)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1115	Shared Neighborhood Hits	964
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

PINK1_MOUSE
θ value	7.1131e-05 (rank : 923)	NC score	0.714499 (rank : 582)
Query Neighborhood Hits	1931	Target Neighborhood Hits	726	Shared Neighborhood Hits	721
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

SCYL2_MOUSE
θ value	7.1131e-05 (rank : 924)	NC score	0.585297 (rank : 783)
Query Neighborhood Hits	1931	Target Neighborhood Hits	603	Shared Neighborhood Hits	549
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

TMIGD_HUMAN
θ value	7.1131e-05 (rank : 925)	NC score	0.346366 (rank : 929)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	225
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

TNI3K_HUMAN
θ value	7.1131e-05 (rank : 926)	NC score	0.632150 (rank : 733)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1084	Shared Neighborhood Hits	803
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ANKK1_MOUSE
θ value	9.29e-05 (rank : 927)	NC score	0.582341 (rank : 788)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1072	Shared Neighborhood Hits	799
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ARHG6_HUMAN
θ value	9.29e-05 (rank : 928)	NC score	0.107403 (rank : 1145)
Query Neighborhood Hits	1931	Target Neighborhood Hits	376	Shared Neighborhood Hits	107
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

BT1A1_HUMAN
θ value	9.29e-05 (rank : 929)	NC score	0.045344 (rank : 1372)
Query Neighborhood Hits	1931	Target Neighborhood Hits	322	Shared Neighborhood Hits	133
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

EPHA3_MOUSE
θ value	9.29e-05 (rank : 930)	NC score	0.654192 (rank : 691)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	913
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

JAK1_HUMAN
θ value	9.29e-05 (rank : 931)	NC score	0.700809 (rank : 602)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	828
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

RAGE_MOUSE
θ value	9.29e-05 (rank : 932)	NC score	0.327440 (rank : 951)
Query Neighborhood Hits	1931	Target Neighborhood Hits	295	Shared Neighborhood Hits	233
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

STK16_HUMAN
θ value	9.29e-05 (rank : 933)	NC score	0.795091 (rank : 386)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	822
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

AATK_MOUSE
θ value	0.000121331 (rank : 934)	NC score	0.615902 (rank : 757)
Query Neighborhood Hits	1931	Target Neighborhood Hits	942	Shared Neighborhood Hits	819
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

IRAK4_HUMAN
θ value	0.000121331 (rank : 935)	NC score	0.755697 (rank : 525)
Query Neighborhood Hits	1931	Target Neighborhood Hits	816	Shared Neighborhood Hits	809
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

IRPL2_MOUSE
θ value	0.000121331 (rank : 936)	NC score	0.183497 (rank : 1046)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	156
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

EPHA6_HUMAN
θ value	0.000158464 (rank : 937)	NC score	0.595943 (rank : 774)
Query Neighborhood Hits	1931	Target Neighborhood Hits	959	Shared Neighborhood Hits	867
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

IRAK4_MOUSE
θ value	0.000158464 (rank : 938)	NC score	0.761301 (rank : 507)
Query Neighborhood Hits	1931	Target Neighborhood Hits	820	Shared Neighborhood Hits	811
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

LRC4B_HUMAN
θ value	0.000158464 (rank : 939)	NC score	0.134611 (rank : 1102)
Query Neighborhood Hits	1931	Target Neighborhood Hits	479	Shared Neighborhood Hits	233
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC4B_MOUSE
θ value	0.000158464 (rank : 940)	NC score	0.135656 (rank : 1100)
Query Neighborhood Hits	1931	Target Neighborhood Hits	484	Shared Neighborhood Hits	233
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

PSG10_HUMAN
θ value	0.000158464 (rank : 941)	NC score	0.213804 (rank : 1021)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	209
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG6_HUMAN
θ value	0.000158464 (rank : 942)	NC score	0.216036 (rank : 1019)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	212
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

STYK1_HUMAN
θ value	0.000158464 (rank : 943)	NC score	0.643756 (rank : 714)
Query Neighborhood Hits	1931	Target Neighborhood Hits	786	Shared Neighborhood Hits	776
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

I11RA_MOUSE
θ value	0.00020696 (rank : 944)	NC score	0.077212 (rank : 1234)
Query Neighborhood Hits	1931	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

IRPL1_MOUSE
θ value	0.00020696 (rank : 945)	NC score	0.181179 (rank : 1047)
Query Neighborhood Hits	1931	Target Neighborhood Hits	186	Shared Neighborhood Hits	168
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

KIT_MOUSE
θ value	0.00020696 (rank : 946)	NC score	0.635785 (rank : 727)
Query Neighborhood Hits	1931	Target Neighborhood Hits	949	Shared Neighborhood Hits	937
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

PSG5_HUMAN
θ value	0.00020696 (rank : 947)	NC score	0.209301 (rank : 1024)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	211
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

STK16_MOUSE
θ value	0.00020696 (rank : 948)	NC score	0.794323 (rank : 391)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	820
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

ANPRB_MOUSE
θ value	0.000270298 (rank : 949)	NC score	0.421021 (rank : 846)
Query Neighborhood Hits	1931	Target Neighborhood Hits	607	Shared Neighborhood Hits	560
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

FCG2A_HUMAN
θ value	0.000270298 (rank : 950)	NC score	0.098198 (rank : 1172)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	84
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

ILRL2_HUMAN
θ value	0.000270298 (rank : 951)	NC score	0.107464 (rank : 1144)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	103
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

JAK1_MOUSE
θ value	0.000270298 (rank : 952)	NC score	0.693984 (rank : 612)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	826
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAM3_MOUSE
θ value	0.000270298 (rank : 953)	NC score	0.327425 (rank : 952)
Query Neighborhood Hits	1931	Target Neighborhood Hits	286	Shared Neighborhood Hits	249
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

NRG1_HUMAN
θ value	0.000270298 (rank : 954)	NC score	0.215112 (rank : 1020)
Query Neighborhood Hits	1931	Target Neighborhood Hits	285	Shared Neighborhood Hits	180
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

TIE1_MOUSE
θ value	0.000270298 (rank : 955)	NC score	0.667524 (rank : 660)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1266	Shared Neighborhood Hits	949
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

VSIG2_MOUSE
θ value	0.000270298 (rank : 956)	NC score	0.296817 (rank : 982)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	247
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

IL1R1_HUMAN
θ value	0.00035302 (rank : 957)	NC score	0.161116 (rank : 1065)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	128
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

IRPL1_HUMAN
θ value	0.00035302 (rank : 958)	NC score	0.177090 (rank : 1048)
Query Neighborhood Hits	1931	Target Neighborhood Hits	196	Shared Neighborhood Hits	176
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

KC1G2_MOUSE
θ value	0.00035302 (rank : 959)	NC score	0.595407 (rank : 775)
Query Neighborhood Hits	1931	Target Neighborhood Hits	695	Shared Neighborhood Hits	691
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

MALT1_HUMAN
θ value	0.00035302 (rank : 960)	NC score	0.342850 (rank : 934)
Query Neighborhood Hits	1931	Target Neighborhood Hits	236	Shared Neighborhood Hits	223
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

PIGR_MOUSE
θ value	0.00035302 (rank : 961)	NC score	0.170097 (rank : 1053)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	164
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

RPKL1_HUMAN
θ value	0.00035302 (rank : 962)	NC score	0.678475 (rank : 634)
Query Neighborhood Hits	1931	Target Neighborhood Hits	708	Shared Neighborhood Hits	659
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

IBP7_MOUSE
θ value	0.000461057 (rank : 963)	NC score	0.252648 (rank : 1003)
Query Neighborhood Hits	1931	Target Neighborhood Hits	230	Shared Neighborhood Hits	168
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IL1R2_HUMAN
θ value	0.000461057 (rank : 964)	NC score	0.205218 (rank : 1026)
Query Neighborhood Hits	1931	Target Neighborhood Hits	153	Shared Neighborhood Hits	144
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

LRRN3_MOUSE
θ value	0.000461057 (rank : 965)	NC score	0.161434 (rank : 1064)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	228
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PRRT3_HUMAN
θ value	0.000461057 (rank : 966)	NC score	0.073294 (rank : 1245)
Query Neighborhood Hits	1931	Target Neighborhood Hits	998	Shared Neighborhood Hits	341
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

STK31_HUMAN
θ value	0.000461057 (rank : 967)	NC score	0.343915 (rank : 932)
Query Neighborhood Hits	1931	Target Neighborhood Hits	570	Shared Neighborhood Hits	377
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

TNI3K_MOUSE
θ value	0.000461057 (rank : 968)	NC score	0.638889 (rank : 721)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1079	Shared Neighborhood Hits	796
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ABR_HUMAN
θ value	0.000602161 (rank : 969)	NC score	0.053799 (rank : 1341)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ANPRB_HUMAN
θ value	0.000602161 (rank : 970)	NC score	0.446936 (rank : 828)
Query Neighborhood Hits	1931	Target Neighborhood Hits	646	Shared Neighborhood Hits	585
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

FGD1_MOUSE
θ value	0.000602161 (rank : 971)	NC score	0.100931 (rank : 1165)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	160
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

JAM2_MOUSE
θ value	0.000602161 (rank : 972)	NC score	0.318824 (rank : 961)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	264
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

KC1G2_HUMAN
θ value	0.000602161 (rank : 973)	NC score	0.593688 (rank : 776)
Query Neighborhood Hits	1931	Target Neighborhood Hits	693	Shared Neighborhood Hits	691
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

NACAM_MOUSE
θ value	0.000602161 (rank : 974)	NC score	0.077457 (rank : 1232)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1866	Shared Neighborhood Hits	447
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

A1BG_HUMAN
θ value	0.000786445 (rank : 975)	NC score	0.069981 (rank : 1257)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

ARHG6_MOUSE
θ value	0.000786445 (rank : 976)	NC score	0.099299 (rank : 1167)
Query Neighborhood Hits	1931	Target Neighborhood Hits	394	Shared Neighborhood Hits	103
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

IGSF2_HUMAN
θ value	0.000786445 (rank : 977)	NC score	0.104872 (rank : 1153)
Query Neighborhood Hits	1931	Target Neighborhood Hits	208	Shared Neighborhood Hits	127
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

JAM3_HUMAN
θ value	0.000786445 (rank : 978)	NC score	0.326225 (rank : 954)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	246
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

NTRK1_HUMAN
θ value	0.000786445 (rank : 979)	NC score	0.647485 (rank : 706)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1023	Shared Neighborhood Hits	896
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

RIPK2_MOUSE
θ value	0.000786445 (rank : 980)	NC score	0.690529 (rank : 615)
Query Neighborhood Hits	1931	Target Neighborhood Hits	776	Shared Neighborhood Hits	755
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

TIE1_HUMAN
θ value	0.000786445 (rank : 981)	NC score	0.661816 (rank : 669)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1241	Shared Neighborhood Hits	934
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

CEAM6_HUMAN
θ value	0.00102713 (rank : 982)	NC score	0.261647 (rank : 997)
Query Neighborhood Hits	1931	Target Neighborhood Hits	308	Shared Neighborhood Hits	266
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

CEAM8_HUMAN
θ value	0.00102713 (rank : 983)	NC score	0.235368 (rank : 1009)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	229
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

ILRL2_MOUSE
θ value	0.00102713 (rank : 984)	NC score	0.154390 (rank : 1075)
Query Neighborhood Hits	1931	Target Neighborhood Hits	158	Shared Neighborhood Hits	148
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

SIGL5_MOUSE
θ value	0.00102713 (rank : 985)	NC score	0.245302 (rank : 1007)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	243
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

STK31_MOUSE
θ value	0.00102713 (rank : 986)	NC score	0.295769 (rank : 983)
Query Neighborhood Hits	1931	Target Neighborhood Hits	474	Shared Neighborhood Hits	313
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

EPN3_MOUSE
θ value	0.00134147 (rank : 987)	NC score	0.028409 (rank : 1494)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	130
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

KC1G3_HUMAN
θ value	0.00134147 (rank : 988)	NC score	0.618638 (rank : 753)
Query Neighborhood Hits	1931	Target Neighborhood Hits	711	Shared Neighborhood Hits	707
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

MFA3L_MOUSE
θ value	0.00134147 (rank : 989)	NC score	0.248034 (rank : 1006)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	197
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

PECA1_MOUSE
θ value	0.00134147 (rank : 990)	NC score	0.161515 (rank : 1063)
Query Neighborhood Hits	1931	Target Neighborhood Hits	126	Shared Neighborhood Hits	111
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

SALL3_HUMAN
θ value	0.00134147 (rank : 991)	NC score	-0.016230 (rank : 2023)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1066	Shared Neighborhood Hits	175
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

SFPQ_MOUSE
θ value	0.00134147 (rank : 992)	NC score	0.036920 (rank : 1421)
Query Neighborhood Hits	1931	Target Neighborhood Hits	958	Shared Neighborhood Hits	194
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

CILP2_HUMAN
θ value	0.00175202 (rank : 993)	NC score	0.202603 (rank : 1031)
Query Neighborhood Hits	1931	Target Neighborhood Hits	307	Shared Neighborhood Hits	207
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CSF1R_HUMAN
θ value	0.00175202 (rank : 994)	NC score	0.609199 (rank : 763)
Query Neighborhood Hits	1931	Target Neighborhood Hits	943	Shared Neighborhood Hits	926
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FGD1_HUMAN
θ value	0.00175202 (rank : 995)	NC score	0.098222 (rank : 1171)
Query Neighborhood Hits	1931	Target Neighborhood Hits	367	Shared Neighborhood Hits	133
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GP116_HUMAN
θ value	0.00175202 (rank : 996)	NC score	0.056468 (rank : 1326)
Query Neighborhood Hits	1931	Target Neighborhood Hits	167	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

I11RB_MOUSE
θ value	0.00175202 (rank : 997)	NC score	0.079459 (rank : 1226)
Query Neighborhood Hits	1931	Target Neighborhood Hits	101	Shared Neighborhood Hits	70
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

MUC18_HUMAN
θ value	0.00175202 (rank : 998)	NC score	0.321779 (rank : 956)
Query Neighborhood Hits	1931	Target Neighborhood Hits	275	Shared Neighborhood Hits	237
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

BSN_HUMAN
θ value	0.00228821 (rank : 999)	NC score	0.062814 (rank : 1293)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1537	Shared Neighborhood Hits	370
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

FARP1_HUMAN
θ value	0.00228821 (rank : 1000)	NC score	0.053032 (rank : 1344)
Query Neighborhood Hits	1931	Target Neighborhood Hits	241	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

IBP7_HUMAN
θ value	0.00228821 (rank : 1001)	NC score	0.262228 (rank : 996)
Query Neighborhood Hits	1931	Target Neighborhood Hits	220	Shared Neighborhood Hits	171
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

LTK_MOUSE
θ value	0.00228821 (rank : 1002)	NC score	0.591703 (rank : 780)
Query Neighborhood Hits	1931	Target Neighborhood Hits	770	Shared Neighborhood Hits	753
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

PSG11_HUMAN
θ value	0.00228821 (rank : 1003)	NC score	0.221738 (rank : 1016)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

RIPK2_HUMAN
θ value	0.00228821 (rank : 1004)	NC score	0.690405 (rank : 616)
Query Neighborhood Hits	1931	Target Neighborhood Hits	774	Shared Neighborhood Hits	756
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

TARA_HUMAN
θ value	0.00228821 (rank : 1005)	NC score	0.043051 (rank : 1379)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1626	Shared Neighborhood Hits	340
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TEX14_HUMAN
θ value	0.00228821 (rank : 1006)	NC score	0.429381 (rank : 839)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1103	Shared Neighborhood Hits	620
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

UFO_MOUSE
θ value	0.00228821 (rank : 1007)	NC score	0.671996 (rank : 653)
Query Neighborhood Hits	1931	Target Neighborhood Hits	988	Shared Neighborhood Hits	927
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

CILP1_MOUSE
θ value	0.00298849 (rank : 1008)	NC score	0.174485 (rank : 1049)
Query Neighborhood Hits	1931	Target Neighborhood Hits	282	Shared Neighborhood Hits	199
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

FCGR1_HUMAN
θ value	0.00298849 (rank : 1009)	NC score	0.138677 (rank : 1091)
Query Neighborhood Hits	1931	Target Neighborhood Hits	145	Shared Neighborhood Hits	118
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

PSG2_HUMAN
θ value	0.00298849 (rank : 1010)	NC score	0.219160 (rank : 1018)
Query Neighborhood Hits	1931	Target Neighborhood Hits	229	Shared Neighborhood Hits	213
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

RPKL1_MOUSE
θ value	0.00298849 (rank : 1011)	NC score	0.680421 (rank : 631)
Query Neighborhood Hits	1931	Target Neighborhood Hits	704	Shared Neighborhood Hits	665
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

SIG12_MOUSE
θ value	0.00298849 (rank : 1012)	NC score	0.144003 (rank : 1085)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	182
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

TEX14_MOUSE
θ value	0.00298849 (rank : 1013)	NC score	0.466313 (rank : 819)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1333	Shared Neighborhood Hits	682
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ATBF1_MOUSE
θ value	0.00390308 (rank : 1014)	NC score	-0.008613 (rank : 2005)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1841	Shared Neighborhood Hits	227
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

DDR1_HUMAN
θ value	0.00390308 (rank : 1015)	NC score	0.598233 (rank : 772)
Query Neighborhood Hits	1931	Target Neighborhood Hits	819	Shared Neighborhood Hits	776
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

EMB_MOUSE
θ value	0.00390308 (rank : 1016)	NC score	0.159194 (rank : 1068)
Query Neighborhood Hits	1931	Target Neighborhood Hits	83	Shared Neighborhood Hits	81
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

FINC_MOUSE
θ value	0.00390308 (rank : 1017)	NC score	0.168457 (rank : 1055)
Query Neighborhood Hits	1931	Target Neighborhood Hits	309	Shared Neighborhood Hits	158
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

FXL19_MOUSE
θ value	0.00390308 (rank : 1018)	NC score	0.020389 (rank : 1550)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	67
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

IGSF8_HUMAN
θ value	0.00390308 (rank : 1019)	NC score	0.068464 (rank : 1264)
Query Neighborhood Hits	1931	Target Neighborhood Hits	88	Shared Neighborhood Hits	49
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

IGSF8_MOUSE
θ value	0.00390308 (rank : 1020)	NC score	0.061612 (rank : 1297)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R366, Q8R0L7	Gene names	Igsf8, Ewi2, Kct4, Pgrl
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory- like protein) (CD316 antigen).

IRAK1_HUMAN
θ value	0.00390308 (rank : 1021)	NC score	0.667991 (rank : 658)
Query Neighborhood Hits	1931	Target Neighborhood Hits	820	Shared Neighborhood Hits	770
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

LTK_HUMAN
θ value	0.00390308 (rank : 1022)	NC score	0.584618 (rank : 784)
Query Neighborhood Hits	1931	Target Neighborhood Hits	774	Shared Neighborhood Hits	756
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

MUC18_MOUSE
θ value	0.00390308 (rank : 1023)	NC score	0.317500 (rank : 963)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	243
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

RIPK3_HUMAN
θ value	0.00390308 (rank : 1024)	NC score	0.735191 (rank : 555)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	811
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

SIG12_HUMAN
θ value	0.00390308 (rank : 1025)	NC score	0.197593 (rank : 1036)
Query Neighborhood Hits	1931	Target Neighborhood Hits	245	Shared Neighborhood Hits	227
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

SSBP4_HUMAN
θ value	0.00390308 (rank : 1026)	NC score	0.032148 (rank : 1459)
Query Neighborhood Hits	1931	Target Neighborhood Hits	753	Shared Neighborhood Hits	254
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

VSIG2_HUMAN
θ value	0.00390308 (rank : 1027)	NC score	0.302740 (rank : 974)
Query Neighborhood Hits	1931	Target Neighborhood Hits	321	Shared Neighborhood Hits	253
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

ESAM_HUMAN
θ value	0.00509761 (rank : 1028)	NC score	0.235532 (rank : 1008)
Query Neighborhood Hits	1931	Target Neighborhood Hits	251	Shared Neighborhood Hits	206
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

FCG2B_HUMAN
θ value	0.00509761 (rank : 1029)	NC score	0.106439 (rank : 1149)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	95
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

FCG2C_HUMAN
θ value	0.00509761 (rank : 1030)	NC score	0.106187 (rank : 1150)
Query Neighborhood Hits	1931	Target Neighborhood Hits	118	Shared Neighborhood Hits	96
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

FINC_HUMAN
θ value	0.00509761 (rank : 1031)	NC score	0.165152 (rank : 1058)
Query Neighborhood Hits	1931	Target Neighborhood Hits	302	Shared Neighborhood Hits	157
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

MLKL_MOUSE
θ value	0.00509761 (rank : 1032)	NC score	0.620066 (rank : 751)
Query Neighborhood Hits	1931	Target Neighborhood Hits	707	Shared Neighborhood Hits	696
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

PECA1_HUMAN
θ value	0.00509761 (rank : 1033)	NC score	0.199071 (rank : 1035)
Query Neighborhood Hits	1931	Target Neighborhood Hits	178	Shared Neighborhood Hits	155
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

PGFRL_MOUSE
θ value	0.00509761 (rank : 1034)	NC score	0.150431 (rank : 1079)
Query Neighborhood Hits	1931	Target Neighborhood Hits	106	Shared Neighborhood Hits	97
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

RGS3_HUMAN
θ value	0.00509761 (rank : 1035)	NC score	0.056105 (rank : 1328)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1375	Shared Neighborhood Hits	381
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

SOS1_HUMAN
θ value	0.00509761 (rank : 1036)	NC score	0.047285 (rank : 1368)
Query Neighborhood Hits	1931	Target Neighborhood Hits	274	Shared Neighborhood Hits	86
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

UFO_HUMAN
θ value	0.00509761 (rank : 1037)	NC score	0.665010 (rank : 664)
Query Neighborhood Hits	1931	Target Neighborhood Hits	981	Shared Neighborhood Hits	921
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

FXL19_HUMAN
θ value	0.00665767 (rank : 1038)	NC score	0.013853 (rank : 1626)
Query Neighborhood Hits	1931	Target Neighborhood Hits	147	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

MUCM_MOUSE
θ value	0.00665767 (rank : 1039)	NC score	0.036635 (rank : 1425)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	P01873	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region membrane-bound form.

MUC_MOUSE
θ value	0.00665767 (rank : 1040)	NC score	0.036926 (rank : 1420)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	74
SwissProt Accessions	P01872	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region secreted form.

PCLO_MOUSE
θ value	0.00665767 (rank : 1041)	NC score	0.058877 (rank : 1308)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2275	Shared Neighborhood Hits	469
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PGFRL_HUMAN
θ value	0.00665767 (rank : 1042)	NC score	0.168933 (rank : 1054)
Query Neighborhood Hits	1931	Target Neighborhood Hits	115	Shared Neighborhood Hits	112
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

RIPK3_MOUSE
θ value	0.00665767 (rank : 1043)	NC score	0.738820 (rank : 549)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	825
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

SIGL8_HUMAN
θ value	0.00665767 (rank : 1044)	NC score	0.203329 (rank : 1029)
Query Neighborhood Hits	1931	Target Neighborhood Hits	252	Shared Neighborhood Hits	224
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

SOX9_MOUSE
θ value	0.00665767 (rank : 1045)	NC score	0.003673 (rank : 1810)
Query Neighborhood Hits	1931	Target Neighborhood Hits	188	Shared Neighborhood Hits	41
SwissProt Accessions	Q04887, Q8C7L2, Q91ZK2, Q99KQ0	Gene names	Sox9, Sox-9
Domain Architecture
Description	Transcription factor SOX-9.

SYNPO_HUMAN
θ value	0.00665767 (rank : 1046)	NC score	0.030705 (rank : 1472)
Query Neighborhood Hits	1931	Target Neighborhood Hits	281	Shared Neighborhood Hits	100
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

UNC5B_MOUSE
θ value	0.00665767 (rank : 1047)	NC score	0.115531 (rank : 1130)
Query Neighborhood Hits	1931	Target Neighborhood Hits	226	Shared Neighborhood Hits	137
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

VRK1_MOUSE
θ value	0.00665767 (rank : 1048)	NC score	0.452941 (rank : 825)
Query Neighborhood Hits	1931	Target Neighborhood Hits	583	Shared Neighborhood Hits	575
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

GUC2C_HUMAN
θ value	0.00869519 (rank : 1049)	NC score	0.456130 (rank : 823)
Query Neighborhood Hits	1931	Target Neighborhood Hits	624	Shared Neighborhood Hits	585
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

MERTK_MOUSE
θ value	0.00869519 (rank : 1050)	NC score	0.663804 (rank : 667)
Query Neighborhood Hits	1931	Target Neighborhood Hits	974	Shared Neighborhood Hits	935
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

VAV3_MOUSE
θ value	0.00869519 (rank : 1051)	NC score	0.135441 (rank : 1101)
Query Neighborhood Hits	1931	Target Neighborhood Hits	404	Shared Neighborhood Hits	148
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

AVR2B_HUMAN
θ value	0.0113563 (rank : 1052)	NC score	0.606371 (rank : 765)
Query Neighborhood Hits	1931	Target Neighborhood Hits	748	Shared Neighborhood Hits	740
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

EPHB6_MOUSE
θ value	0.0113563 (rank : 1053)	NC score	0.555744 (rank : 800)
Query Neighborhood Hits	1931	Target Neighborhood Hits	906	Shared Neighborhood Hits	797
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ESAM_MOUSE
θ value	0.0113563 (rank : 1054)	NC score	0.209346 (rank : 1023)
Query Neighborhood Hits	1931	Target Neighborhood Hits	222	Shared Neighborhood Hits	188
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

KC1G1_HUMAN
θ value	0.0113563 (rank : 1055)	NC score	0.621452 (rank : 750)
Query Neighborhood Hits	1931	Target Neighborhood Hits	708	Shared Neighborhood Hits	704
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	0.0113563 (rank : 1056)	NC score	0.623286 (rank : 747)
Query Neighborhood Hits	1931	Target Neighborhood Hits	713	Shared Neighborhood Hits	706
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

NRBP_MOUSE
θ value	0.0113563 (rank : 1057)	NC score	0.459596 (rank : 822)
Query Neighborhood Hits	1931	Target Neighborhood Hits	442	Shared Neighborhood Hits	419
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

OGFR_HUMAN
θ value	0.0113563 (rank : 1058)	NC score	0.070013 (rank : 1255)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1582	Shared Neighborhood Hits	445
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

SHPS1_MOUSE
θ value	0.0113563 (rank : 1059)	NC score	0.066104 (rank : 1274)
Query Neighborhood Hits	1931	Target Neighborhood Hits	439	Shared Neighborhood Hits	139
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

AMGO1_MOUSE
θ value	0.0148317 (rank : 1060)	NC score	0.048812 (rank : 1366)
Query Neighborhood Hits	1931	Target Neighborhood Hits	325	Shared Neighborhood Hits	94
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

BAT2_HUMAN
θ value	0.0148317 (rank : 1061)	NC score	0.054623 (rank : 1334)
Query Neighborhood Hits	1931	Target Neighborhood Hits	931	Shared Neighborhood Hits	277
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CD166_MOUSE
θ value	0.0148317 (rank : 1062)	NC score	0.260039 (rank : 998)
Query Neighborhood Hits	1931	Target Neighborhood Hits	252	Shared Neighborhood Hits	218
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

CXAR_HUMAN
θ value	0.0148317 (rank : 1063)	NC score	0.202927 (rank : 1030)
Query Neighborhood Hits	1931	Target Neighborhood Hits	245	Shared Neighborhood Hits	188
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

KS6C1_MOUSE
θ value	0.0148317 (rank : 1064)	NC score	0.659019 (rank : 677)
Query Neighborhood Hits	1931	Target Neighborhood Hits	700	Shared Neighborhood Hits	637
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

SEM4C_HUMAN
θ value	0.0148317 (rank : 1065)	NC score	0.027393 (rank : 1502)
Query Neighborhood Hits	1931	Target Neighborhood Hits	84	Shared Neighborhood Hits	38
SwissProt Accessions	Q9C0C4, Q7Z5X0	Gene names	SEMA4C, KIAA1739
Domain Architecture
Description	Semaphorin-4C precursor.

SFPQ_HUMAN
θ value	0.0148317 (rank : 1066)	NC score	0.043156 (rank : 1378)
Query Neighborhood Hits	1931	Target Neighborhood Hits	986	Shared Neighborhood Hits	213
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

SRRM2_HUMAN
θ value	0.0148317 (rank : 1067)	NC score	0.064154 (rank : 1281)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1296	Shared Neighborhood Hits	287
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

ACVR1_HUMAN
θ value	0.0193708 (rank : 1068)	NC score	0.601501 (rank : 769)
Query Neighborhood Hits	1931	Target Neighborhood Hits	760	Shared Neighborhood Hits	754
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	0.0193708 (rank : 1069)	NC score	0.607356 (rank : 764)
Query Neighborhood Hits	1931	Target Neighborhood Hits	768	Shared Neighborhood Hits	760
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

CILP1_HUMAN
θ value	0.0193708 (rank : 1070)	NC score	0.162904 (rank : 1061)
Query Neighborhood Hits	1931	Target Neighborhood Hits	266	Shared Neighborhood Hits	178
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

MLKL_HUMAN
θ value	0.0193708 (rank : 1071)	NC score	0.530819 (rank : 806)
Query Neighborhood Hits	1931	Target Neighborhood Hits	600	Shared Neighborhood Hits	580
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

SIGIR_MOUSE
θ value	0.0193708 (rank : 1072)	NC score	0.080632 (rank : 1222)
Query Neighborhood Hits	1931	Target Neighborhood Hits	95	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

TGFR2_HUMAN
θ value	0.0193708 (rank : 1073)	NC score	0.617654 (rank : 755)
Query Neighborhood Hits	1931	Target Neighborhood Hits	748	Shared Neighborhood Hits	743
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	0.0193708 (rank : 1074)	NC score	0.617694 (rank : 754)
Query Neighborhood Hits	1931	Target Neighborhood Hits	748	Shared Neighborhood Hits	744
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

VRK2_HUMAN
θ value	0.0193708 (rank : 1075)	NC score	0.451745 (rank : 826)
Query Neighborhood Hits	1931	Target Neighborhood Hits	582	Shared Neighborhood Hits	562
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

ALK_MOUSE
θ value	0.0252991 (rank : 1076)	NC score	0.590788 (rank : 781)
Query Neighborhood Hits	1931	Target Neighborhood Hits	811	Shared Neighborhood Hits	757
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AVR2A_HUMAN
θ value	0.0252991 (rank : 1077)	NC score	0.621547 (rank : 749)
Query Neighborhood Hits	1931	Target Neighborhood Hits	767	Shared Neighborhood Hits	763
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	0.0252991 (rank : 1078)	NC score	0.621561 (rank : 748)
Query Neighborhood Hits	1931	Target Neighborhood Hits	767	Shared Neighborhood Hits	763
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2B_MOUSE
θ value	0.0252991 (rank : 1079)	NC score	0.606340 (rank : 766)
Query Neighborhood Hits	1931	Target Neighborhood Hits	749	Shared Neighborhood Hits	740
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

CSF1R_MOUSE
θ value	0.0252991 (rank : 1080)	NC score	0.625826 (rank : 745)
Query Neighborhood Hits	1931	Target Neighborhood Hits	983	Shared Neighborhood Hits	963
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

I11RA_HUMAN
θ value	0.0252991 (rank : 1081)	NC score	0.074398 (rank : 1242)
Query Neighborhood Hits	1931	Target Neighborhood Hits	138	Shared Neighborhood Hits	82
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

ILRL1_HUMAN
θ value	0.0252991 (rank : 1082)	NC score	0.144743 (rank : 1083)
Query Neighborhood Hits	1931	Target Neighborhood Hits	167	Shared Neighborhood Hits	137
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

K1802_MOUSE
θ value	0.0252991 (rank : 1083)	NC score	0.030889 (rank : 1467)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1596	Shared Neighborhood Hits	356
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

NRBP_HUMAN
θ value	0.0252991 (rank : 1084)	NC score	0.461684 (rank : 821)
Query Neighborhood Hits	1931	Target Neighborhood Hits	448	Shared Neighborhood Hits	423
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

SEM3A_MOUSE
θ value	0.0252991 (rank : 1085)	NC score	0.021245 (rank : 1541)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	48
SwissProt Accessions	O08665, Q5BL08, Q62180, Q62215	Gene names	Sema3a, Semad, SemD
Domain Architecture
Description	Semaphorin-3A precursor (Semaphorin III) (Sema III) (Semaphorin D) (Sema D).

SRPK1_HUMAN
θ value	0.0252991 (rank : 1086)	NC score	0.516240 (rank : 812)
Query Neighborhood Hits	1931	Target Neighborhood Hits	706	Shared Neighborhood Hits	589
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_HUMAN
θ value	0.0252991 (rank : 1087)	NC score	0.517539 (rank : 811)
Query Neighborhood Hits	1931	Target Neighborhood Hits	664	Shared Neighborhood Hits	573
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	0.0252991 (rank : 1088)	NC score	0.514818 (rank : 813)
Query Neighborhood Hits	1931	Target Neighborhood Hits	765	Shared Neighborhood Hits	584
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

VAV3_HUMAN
θ value	0.0252991 (rank : 1089)	NC score	0.135989 (rank : 1098)
Query Neighborhood Hits	1931	Target Neighborhood Hits	398	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

WASP_MOUSE
θ value	0.0252991 (rank : 1090)	NC score	0.033022 (rank : 1453)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	98
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

ZN676_HUMAN
θ value	0.0252991 (rank : 1091)	NC score	-0.025338 (rank : 2035)
Query Neighborhood Hits	1931	Target Neighborhood Hits	754	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N7Q3	Gene names	ZNF676
Domain Architecture	No domain graphic available
Description	Zinc finger protein 676.

CD7_HUMAN
θ value	0.0330416 (rank : 1092)	NC score	0.036048 (rank : 1429)
Query Neighborhood Hits	1931	Target Neighborhood Hits	190	Shared Neighborhood Hits	56
SwissProt Accessions	P09564	Gene names	CD7
Domain Architecture
Description	T-cell antigen CD7 precursor (GP40) (T-cell leukemia antigen) (TP41) (Leu-9).

CO7A1_HUMAN
θ value	0.0330416 (rank : 1093)	NC score	0.092667 (rank : 1184)
Query Neighborhood Hits	1931	Target Neighborhood Hits	807	Shared Neighborhood Hits	293
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

HV04_MOUSE
θ value	0.0330416 (rank : 1094)	NC score	-0.000356 (rank : 1912)
Query Neighborhood Hits	1931	Target Neighborhood Hits	243	Shared Neighborhood Hits	45
SwissProt Accessions	P01748	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region 23 precursor.

IL1R1_MOUSE
θ value	0.0330416 (rank : 1095)	NC score	0.144633 (rank : 1084)
Query Neighborhood Hits	1931	Target Neighborhood Hits	142	Shared Neighborhood Hits	130
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

IL1R2_MOUSE
θ value	0.0330416 (rank : 1096)	NC score	0.173797 (rank : 1050)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	111
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

IRAK1_MOUSE
θ value	0.0330416 (rank : 1097)	NC score	0.663974 (rank : 666)
Query Neighborhood Hits	1931	Target Neighborhood Hits	784	Shared Neighborhood Hits	753
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

IRAK3_MOUSE
θ value	0.0330416 (rank : 1098)	NC score	0.579531 (rank : 793)
Query Neighborhood Hits	1931	Target Neighborhood Hits	628	Shared Neighborhood Hits	608
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

K0310_HUMAN
θ value	0.0330416 (rank : 1099)	NC score	0.036446 (rank : 1426)
Query Neighborhood Hits	1931	Target Neighborhood Hits	420	Shared Neighborhood Hits	141
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

KS6C1_HUMAN
θ value	0.0330416 (rank : 1100)	NC score	0.655590 (rank : 684)
Query Neighborhood Hits	1931	Target Neighborhood Hits	682	Shared Neighborhood Hits	640
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

MFAP3_MOUSE
θ value	0.0330416 (rank : 1101)	NC score	0.092004 (rank : 1187)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	89
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

SEM3B_HUMAN
θ value	0.0330416 (rank : 1102)	NC score	0.019744 (rank : 1555)
Query Neighborhood Hits	1931	Target Neighborhood Hits	76	Shared Neighborhood Hits	35
SwissProt Accessions	Q13214, Q8TB71, Q8TDV7, Q93018, Q96GX0	Gene names	SEMA3B, SEMA5
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin V) (Sema V) (Sema A(V)).

SEM3F_HUMAN
θ value	0.0330416 (rank : 1103)	NC score	0.026560 (rank : 1507)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q13275, Q13274, Q13372, Q15704	Gene names	SEMA3F
Domain Architecture
Description	Semaphorin-3F precursor (Semaphorin IV) (Sema IV) (Sema III/F).

SOS1_MOUSE
θ value	0.0330416 (rank : 1104)	NC score	0.046390 (rank : 1369)
Query Neighborhood Hits	1931	Target Neighborhood Hits	281	Shared Neighborhood Hits	91
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

SRPK1_MOUSE
θ value	0.0330416 (rank : 1105)	NC score	0.518348 (rank : 810)
Query Neighborhood Hits	1931	Target Neighborhood Hits	639	Shared Neighborhood Hits	566
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SYNJ1_MOUSE
θ value	0.0330416 (rank : 1106)	NC score	0.033102 (rank : 1451)
Query Neighborhood Hits	1931	Target Neighborhood Hits	516	Shared Neighborhood Hits	174
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TIMD1_HUMAN
θ value	0.0330416 (rank : 1107)	NC score	0.039742 (rank : 1398)
Query Neighborhood Hits	1931	Target Neighborhood Hits	155	Shared Neighborhood Hits	60
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

UNC5B_HUMAN
θ value	0.0330416 (rank : 1108)	NC score	0.117305 (rank : 1127)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	138
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

WBP11_HUMAN
θ value	0.0330416 (rank : 1109)	NC score	0.038216 (rank : 1407)
Query Neighborhood Hits	1931	Target Neighborhood Hits	354	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	0.0330416 (rank : 1110)	NC score	0.037100 (rank : 1419)
Query Neighborhood Hits	1931	Target Neighborhood Hits	362	Shared Neighborhood Hits	116
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

ALK_HUMAN
θ value	0.0431538 (rank : 1111)	NC score	0.592724 (rank : 779)
Query Neighborhood Hits	1931	Target Neighborhood Hits	795	Shared Neighborhood Hits	742
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ARHGA_MOUSE
θ value	0.0431538 (rank : 1112)	NC score	0.081426 (rank : 1220)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	62
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CD166_HUMAN
θ value	0.0431538 (rank : 1113)	NC score	0.248267 (rank : 1005)
Query Neighborhood Hits	1931	Target Neighborhood Hits	247	Shared Neighborhood Hits	217
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

CD19_HUMAN
θ value	0.0431538 (rank : 1114)	NC score	0.028170 (rank : 1495)
Query Neighborhood Hits	1931	Target Neighborhood Hits	63	Shared Neighborhood Hits	26
SwissProt Accessions	P15391, Q96S68, Q9BRD6	Gene names	CD19
Domain Architecture
Description	B-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B- lymphocyte surface antigen B4) (Leu-12).

CD48_MOUSE
θ value	0.0431538 (rank : 1115)	NC score	0.070776 (rank : 1252)
Query Neighborhood Hits	1931	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	P18181, Q545K2	Gene names	Cd48, Bcm-1
Domain Architecture
Description	CD48 antigen precursor (MRC OX-45 surface antigen) (BCM1 surface antigen) (BLAST-1) (HM48-1) (sgp-60).

CO3A1_HUMAN
θ value	0.0431538 (rank : 1116)	NC score	0.016700 (rank : 1599)
Query Neighborhood Hits	1931	Target Neighborhood Hits	452	Shared Neighborhood Hits	146
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

FCGR1_MOUSE
θ value	0.0431538 (rank : 1117)	NC score	0.118467 (rank : 1126)
Query Neighborhood Hits	1931	Target Neighborhood Hits	123	Shared Neighborhood Hits	99
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

HV48_MOUSE
θ value	0.0431538 (rank : 1118)	NC score	-0.001279 (rank : 1928)
Query Neighborhood Hits	1931	Target Neighborhood Hits	246	Shared Neighborhood Hits	45
SwissProt Accessions	P03980	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region TEPC 1017 precursor.

I28RA_MOUSE
θ value	0.0431538 (rank : 1119)	NC score	0.016796 (rank : 1597)
Query Neighborhood Hits	1931	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CGK5, Q6PEV1	Gene names	Il28ra, Ifnlr1
Domain Architecture	No domain graphic available
Description	Interleukin-28 receptor alpha chain precursor (IL-28R-alpha) (IL-28RA) (Cytokine receptor family 2 member 12) (Cytokine receptor class-II member 12) (CRF2-12) (Interferon lambda receptor 1) (IFN-lambda R1).

LV4E_HUMAN
θ value	0.0431538 (rank : 1120)	NC score	0.001724 (rank : 1861)
Query Neighborhood Hits	1931	Target Neighborhood Hits	218	Shared Neighborhood Hits	58
SwissProt Accessions	P06889	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-IV region MOL.

MERTK_HUMAN
θ value	0.0431538 (rank : 1121)	NC score	0.659745 (rank : 674)
Query Neighborhood Hits	1931	Target Neighborhood Hits	988	Shared Neighborhood Hits	953
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MLL2_HUMAN
θ value	0.0431538 (rank : 1122)	NC score	0.037763 (rank : 1412)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1788	Shared Neighborhood Hits	375
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PRP2_MOUSE
θ value	0.0431538 (rank : 1123)	NC score	0.054617 (rank : 1335)
Query Neighborhood Hits	1931	Target Neighborhood Hits	347	Shared Neighborhood Hits	124
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

SPR1B_MOUSE
θ value	0.0431538 (rank : 1124)	NC score	0.045233 (rank : 1373)
Query Neighborhood Hits	1931	Target Neighborhood Hits	395	Shared Neighborhood Hits	158
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SYN1_MOUSE
θ value	0.0431538 (rank : 1125)	NC score	0.034966 (rank : 1436)
Query Neighborhood Hits	1931	Target Neighborhood Hits	363	Shared Neighborhood Hits	141
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

UNC5C_MOUSE
θ value	0.0431538 (rank : 1126)	NC score	0.123312 (rank : 1116)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	141
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UPK3B_HUMAN
θ value	0.0431538 (rank : 1127)	NC score	0.019640 (rank : 1557)
Query Neighborhood Hits	1931	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BT76, Q86W06	Gene names	UPK3B
Domain Architecture	No domain graphic available
Description	Uroplakin-3B precursor (Uroplakin IIIb) (UPIIIb) (p35).

VRK1_HUMAN
θ value	0.0431538 (rank : 1128)	NC score	0.447011 (rank : 827)
Query Neighborhood Hits	1931	Target Neighborhood Hits	584	Shared Neighborhood Hits	574
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

ENL_HUMAN
θ value	0.0563607 (rank : 1129)	NC score	0.031167 (rank : 1464)
Query Neighborhood Hits	1931	Target Neighborhood Hits	305	Shared Neighborhood Hits	69
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

EPHAA_HUMAN
θ value	0.0563607 (rank : 1130)	NC score	0.545240 (rank : 802)
Query Neighborhood Hits	1931	Target Neighborhood Hits	960	Shared Neighborhood Hits	807
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_HUMAN
θ value	0.0563607 (rank : 1131)	NC score	0.542407 (rank : 804)
Query Neighborhood Hits	1931	Target Neighborhood Hits	912	Shared Neighborhood Hits	783
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

IL18R_MOUSE
θ value	0.0563607 (rank : 1132)	NC score	0.054041 (rank : 1339)
Query Neighborhood Hits	1931	Target Neighborhood Hits	82	Shared Neighborhood Hits	47
SwissProt Accessions	Q61098	Gene names	Il18r1
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp).

IZUM1_HUMAN
θ value	0.0563607 (rank : 1133)	NC score	0.033106 (rank : 1450)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IYV9, Q6Q8P6, Q6Q8P7	Gene names	IZUMO1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).

KC1D_HUMAN
θ value	0.0563607 (rank : 1134)	NC score	0.629613 (rank : 736)
Query Neighborhood Hits	1931	Target Neighborhood Hits	737	Shared Neighborhood Hits	727
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	0.0563607 (rank : 1135)	NC score	0.629609 (rank : 737)
Query Neighborhood Hits	1931	Target Neighborhood Hits	737	Shared Neighborhood Hits	727
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	0.0563607 (rank : 1136)	NC score	0.626431 (rank : 743)
Query Neighborhood Hits	1931	Target Neighborhood Hits	732	Shared Neighborhood Hits	724
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	0.0563607 (rank : 1137)	NC score	0.626421 (rank : 744)
Query Neighborhood Hits	1931	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

RYK_HUMAN
θ value	0.0563607 (rank : 1138)	NC score	0.521677 (rank : 809)
Query Neighborhood Hits	1931	Target Neighborhood Hits	701	Shared Neighborhood Hits	692
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	0.0563607 (rank : 1139)	NC score	0.535034 (rank : 805)
Query Neighborhood Hits	1931	Target Neighborhood Hits	715	Shared Neighborhood Hits	703
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SEM3D_HUMAN
θ value	0.0563607 (rank : 1140)	NC score	0.020616 (rank : 1545)
Query Neighborhood Hits	1931	Target Neighborhood Hits	104	Shared Neighborhood Hits	46
SwissProt Accessions	O95025, Q6UW77, Q8NCQ1	Gene names	SEMA3D
Domain Architecture
Description	Semaphorin-3D precursor.

SEM3F_MOUSE
θ value	0.0563607 (rank : 1141)	NC score	0.023103 (rank : 1529)
Query Neighborhood Hits	1931	Target Neighborhood Hits	86	Shared Neighborhood Hits	46
SwissProt Accessions	O88632, O88633	Gene names	Sema3f
Domain Architecture
Description	Semaphorin-3F precursor (Semaphorin IV) (Sema IV).

SMOO_HUMAN
θ value	0.0563607 (rank : 1142)	NC score	0.022165 (rank : 1535)
Query Neighborhood Hits	1931	Target Neighborhood Hits	391	Shared Neighborhood Hits	120
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

TB182_HUMAN
θ value	0.0563607 (rank : 1143)	NC score	0.035194 (rank : 1434)
Query Neighborhood Hits	1931	Target Neighborhood Hits	414	Shared Neighborhood Hits	116
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

AMGO1_HUMAN
θ value	0.0736092 (rank : 1144)	NC score	0.057155 (rank : 1321)
Query Neighborhood Hits	1931	Target Neighborhood Hits	353	Shared Neighborhood Hits	118
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

ARHG3_MOUSE
θ value	0.0736092 (rank : 1145)	NC score	0.078497 (rank : 1230)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

BAT2_MOUSE
θ value	0.0736092 (rank : 1146)	NC score	0.049219 (rank : 1363)
Query Neighborhood Hits	1931	Target Neighborhood Hits	947	Shared Neighborhood Hits	296
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CJ026_MOUSE
θ value	0.0736092 (rank : 1147)	NC score	0.015709 (rank : 1606)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BGW2, Q3TF48, Q3U3M2, Q6PD43, Q8R0W8	Gene names	D19Wsu162e
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf26 homolog.

DIAP2_HUMAN
θ value	0.0736092 (rank : 1148)	NC score	0.011082 (rank : 1672)
Query Neighborhood Hits	1931	Target Neighborhood Hits	342	Shared Neighborhood Hits	72
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

EPN1_HUMAN
θ value	0.0736092 (rank : 1149)	NC score	0.019893 (rank : 1554)
Query Neighborhood Hits	1931	Target Neighborhood Hits	206	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

I18RA_HUMAN
θ value	0.0736092 (rank : 1150)	NC score	0.066170 (rank : 1273)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	70
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

IL6RA_HUMAN
θ value	0.0736092 (rank : 1151)	NC score	0.059724 (rank : 1303)
Query Neighborhood Hits	1931	Target Neighborhood Hits	96	Shared Neighborhood Hits	63
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

IP3KA_HUMAN
θ value	0.0736092 (rank : 1152)	NC score	0.009838 (rank : 1691)
Query Neighborhood Hits	1931	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	P23677, Q8TAN3	Gene names	ITPKA
Domain Architecture
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

RX_MOUSE
θ value	0.0736092 (rank : 1153)	NC score	-0.011632 (rank : 2011)
Query Neighborhood Hits	1931	Target Neighborhood Hits	429	Shared Neighborhood Hits	53
SwissProt Accessions	O35602, O08748	Gene names	Rax, Rx
Domain Architecture
Description	Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein).

SHPS1_HUMAN
θ value	0.0736092 (rank : 1154)	NC score	0.093517 (rank : 1182)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	159
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

SOS2_HUMAN
θ value	0.0736092 (rank : 1155)	NC score	0.045541 (rank : 1371)
Query Neighborhood Hits	1931	Target Neighborhood Hits	193	Shared Neighborhood Hits	61
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOX9_HUMAN
θ value	0.0736092 (rank : 1156)	NC score	0.004012 (rank : 1802)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	56
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

SPT5H_HUMAN
θ value	0.0736092 (rank : 1157)	NC score	0.030545 (rank : 1474)
Query Neighborhood Hits	1931	Target Neighborhood Hits	436	Shared Neighborhood Hits	159
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	0.0736092 (rank : 1158)	NC score	0.030141 (rank : 1476)
Query Neighborhood Hits	1931	Target Neighborhood Hits	437	Shared Neighborhood Hits	158
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

STK23_HUMAN
θ value	0.0736092 (rank : 1159)	NC score	0.512717 (rank : 815)
Query Neighborhood Hits	1931	Target Neighborhood Hits	556	Shared Neighborhood Hits	552
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SYN1_HUMAN
θ value	0.0736092 (rank : 1160)	NC score	0.033410 (rank : 1448)
Query Neighborhood Hits	1931	Target Neighborhood Hits	419	Shared Neighborhood Hits	151
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

TRIM9_MOUSE
θ value	0.0736092 (rank : 1161)	NC score	0.025182 (rank : 1513)
Query Neighborhood Hits	1931	Target Neighborhood Hits	274	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

TTBK1_HUMAN
θ value	0.0736092 (rank : 1162)	NC score	0.652842 (rank : 696)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1058	Shared Neighborhood Hits	781
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	0.0736092 (rank : 1163)	NC score	0.641419 (rank : 718)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	721
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	0.0736092 (rank : 1164)	NC score	0.638626 (rank : 722)
Query Neighborhood Hits	1931	Target Neighborhood Hits	811	Shared Neighborhood Hits	713
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

ANPRA_MOUSE
θ value	0.0961366 (rank : 1165)	NC score	0.410715 (rank : 864)
Query Neighborhood Hits	1931	Target Neighborhood Hits	600	Shared Neighborhood Hits	539
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ATN1_HUMAN
θ value	0.0961366 (rank : 1166)	NC score	0.038846 (rank : 1405)
Query Neighborhood Hits	1931	Target Neighborhood Hits	676	Shared Neighborhood Hits	173
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BT1A1_MOUSE
θ value	0.0961366 (rank : 1167)	NC score	0.050159 (rank : 1361)
Query Neighborhood Hits	1931	Target Neighborhood Hits	252	Shared Neighborhood Hits	136
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

CD4_HUMAN
θ value	0.0961366 (rank : 1168)	NC score	0.079217 (rank : 1227)
Query Neighborhood Hits	1931	Target Neighborhood Hits	122	Shared Neighborhood Hits	68
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

CEL_HUMAN
θ value	0.0961366 (rank : 1169)	NC score	0.028954 (rank : 1489)
Query Neighborhood Hits	1931	Target Neighborhood Hits	896	Shared Neighborhood Hits	271
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CO3A1_MOUSE
θ value	0.0961366 (rank : 1170)	NC score	0.015449 (rank : 1611)
Query Neighborhood Hits	1931	Target Neighborhood Hits	466	Shared Neighborhood Hits	149
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

ILK1_HUMAN
θ value	0.0961366 (rank : 1171)	NC score	0.405765 (rank : 873)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	593
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
θ value	0.0961366 (rank : 1172)	NC score	0.403818 (rank : 877)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	594
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILRL1_MOUSE
θ value	0.0961366 (rank : 1173)	NC score	0.116550 (rank : 1129)
Query Neighborhood Hits	1931	Target Neighborhood Hits	172	Shared Neighborhood Hits	139
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

ITSN2_HUMAN
θ value	0.0961366 (rank : 1174)	NC score	0.085938 (rank : 1201)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1173	Shared Neighborhood Hits	185
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

LRRN1_HUMAN
θ value	0.0961366 (rank : 1175)	NC score	0.163011 (rank : 1060)
Query Neighborhood Hits	1931	Target Neighborhood Hits	518	Shared Neighborhood Hits	261
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

MARCS_MOUSE
θ value	0.0961366 (rank : 1176)	NC score	0.039982 (rank : 1395)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

NEUG_MOUSE
θ value	0.0961366 (rank : 1177)	NC score	0.039882 (rank : 1396)
Query Neighborhood Hits	1931	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	P60761, Q3TYH4	Gene names	Nrgn
Domain Architecture	No domain graphic available
Description	Neurogranin (Ng) (RC3).

SEM4D_HUMAN
θ value	0.0961366 (rank : 1178)	NC score	0.034368 (rank : 1442)
Query Neighborhood Hits	1931	Target Neighborhood Hits	139	Shared Neighborhood Hits	86
SwissProt Accessions	Q92854, Q7Z5S4	Gene names	SEMA4D, CD100
Domain Architecture
Description	Semaphorin-4D precursor (Leukocyte activation antigen CD100) (BB18) (A8) (GR3).

SIGL7_HUMAN
θ value	0.0961366 (rank : 1179)	NC score	0.152372 (rank : 1078)
Query Neighborhood Hits	1931	Target Neighborhood Hits	180	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

SYNJ1_HUMAN
θ value	0.0961366 (rank : 1180)	NC score	0.024001 (rank : 1524)
Query Neighborhood Hits	1931	Target Neighborhood Hits	498	Shared Neighborhood Hits	162
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TTC15_HUMAN
θ value	0.0961366 (rank : 1181)	NC score	0.019014 (rank : 1573)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WVT3, Q8WVW1, Q9Y395	Gene names	TTC15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

TXND2_HUMAN
θ value	0.0961366 (rank : 1182)	NC score	0.043645 (rank : 1377)
Query Neighborhood Hits	1931	Target Neighborhood Hits	793	Shared Neighborhood Hits	169
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

USH2A_MOUSE
θ value	0.0961366 (rank : 1183)	NC score	0.126285 (rank : 1111)
Query Neighborhood Hits	1931	Target Neighborhood Hits	626	Shared Neighborhood Hits	187
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

VSX1_HUMAN
θ value	0.0961366 (rank : 1184)	NC score	-0.010376 (rank : 2008)
Query Neighborhood Hits	1931	Target Neighborhood Hits	344	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZR4, Q5TF40, Q5TF41, Q9HCU3, Q9NU27	Gene names	VSX1, RINX
Domain Architecture
Description	Visual system homeobox 1 (Transcription factor VSX1) (Retinal inner nuclear layer homeobox protein) (Homeodomain protein RINX).

ZN687_MOUSE
θ value	0.0961366 (rank : 1185)	NC score	-0.015595 (rank : 2020)
Query Neighborhood Hits	1931	Target Neighborhood Hits	913	Shared Neighborhood Hits	136
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

BSN_MOUSE
θ value	0.125558 (rank : 1186)	NC score	0.065958 (rank : 1276)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2057	Shared Neighborhood Hits	470
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CSPG4_MOUSE
θ value	0.125558 (rank : 1187)	NC score	0.010251 (rank : 1686)
Query Neighborhood Hits	1931	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VHY0, Q5DTG1, Q8BPI8, Q8CE79	Gene names	Cspg4, An2, Kiaa4232, Ng2
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (AN2 proteoglycan).

ILK2_HUMAN
θ value	0.125558 (rank : 1188)	NC score	0.392411 (rank : 895)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	585
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

JPH2_HUMAN
θ value	0.125558 (rank : 1189)	NC score	0.034755 (rank : 1437)
Query Neighborhood Hits	1931	Target Neighborhood Hits	639	Shared Neighborhood Hits	237
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

LRRC4_HUMAN
θ value	0.125558 (rank : 1190)	NC score	0.118716 (rank : 1124)
Query Neighborhood Hits	1931	Target Neighborhood Hits	444	Shared Neighborhood Hits	203
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

LV3A_HUMAN
θ value	0.125558 (rank : 1191)	NC score	0.001525 (rank : 1866)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	P01714	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-III region SH.

NCOA6_HUMAN
θ value	0.125558 (rank : 1192)	NC score	0.056537 (rank : 1324)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1202	Shared Neighborhood Hits	357
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NEUG_HUMAN
θ value	0.125558 (rank : 1193)	NC score	0.040652 (rank : 1391)
Query Neighborhood Hits	1931	Target Neighborhood Hits	9	Shared Neighborhood Hits	7
SwissProt Accessions	Q92686	Gene names	NRGN
Domain Architecture	No domain graphic available
Description	Neurogranin (Ng) (RC3).

PRG4_HUMAN
θ value	0.125558 (rank : 1194)	NC score	0.039408 (rank : 1401)
Query Neighborhood Hits	1931	Target Neighborhood Hits	764	Shared Neighborhood Hits	186
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SAPS1_HUMAN
θ value	0.125558 (rank : 1195)	NC score	0.037679 (rank : 1414)
Query Neighborhood Hits	1931	Target Neighborhood Hits	704	Shared Neighborhood Hits	256
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SEM3D_MOUSE
θ value	0.125558 (rank : 1196)	NC score	0.020986 (rank : 1543)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BH34	Gene names	Sema3d
Domain Architecture	No domain graphic available
Description	Semaphorin-3D precursor.

SIRB1_HUMAN
θ value	0.125558 (rank : 1197)	NC score	0.084145 (rank : 1208)
Query Neighborhood Hits	1931	Target Neighborhood Hits	422	Shared Neighborhood Hits	147
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

UNC5C_HUMAN
θ value	0.125558 (rank : 1198)	NC score	0.121807 (rank : 1122)
Query Neighborhood Hits	1931	Target Neighborhood Hits	226	Shared Neighborhood Hits	136
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

VRK2_MOUSE
θ value	0.125558 (rank : 1199)	NC score	0.455632 (rank : 824)
Query Neighborhood Hits	1931	Target Neighborhood Hits	586	Shared Neighborhood Hits	574
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

ZN267_HUMAN
θ value	0.125558 (rank : 1200)	NC score	-0.026059 (rank : 2044)
Query Neighborhood Hits	1931	Target Neighborhood Hits	786	Shared Neighborhood Hits	54
SwissProt Accessions	Q14586, Q8NE41, Q9NRJ0	Gene names	ZNF267
Domain Architecture
Description	Zinc finger protein 267 (Zinc finger protein HZF2).

AMGO3_MOUSE
θ value	0.163984 (rank : 1201)	NC score	0.052894 (rank : 1345)
Query Neighborhood Hits	1931	Target Neighborhood Hits	276	Shared Neighborhood Hits	81
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

AMHR2_HUMAN
θ value	0.163984 (rank : 1202)	NC score	0.486967 (rank : 817)
Query Neighborhood Hits	1931	Target Neighborhood Hits	715	Shared Neighborhood Hits	668
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ARHG3_HUMAN
θ value	0.163984 (rank : 1203)	NC score	0.079736 (rank : 1224)
Query Neighborhood Hits	1931	Target Neighborhood Hits	82	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

CD276_HUMAN
θ value	0.163984 (rank : 1204)	NC score	0.189515 (rank : 1042)
Query Neighborhood Hits	1931	Target Neighborhood Hits	261	Shared Neighborhood Hits	188
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

COAA1_HUMAN
θ value	0.163984 (rank : 1205)	NC score	0.007915 (rank : 1727)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	118
SwissProt Accessions	Q03692	Gene names	COL10A1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

CSKI2_HUMAN
θ value	0.163984 (rank : 1206)	NC score	0.030912 (rank : 1466)
Query Neighborhood Hits	1931	Target Neighborhood Hits	747	Shared Neighborhood Hits	194
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CXAR_MOUSE
θ value	0.163984 (rank : 1207)	NC score	0.192096 (rank : 1038)
Query Neighborhood Hits	1931	Target Neighborhood Hits	250	Shared Neighborhood Hits	187
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

DUS8_HUMAN
θ value	0.163984 (rank : 1208)	NC score	0.007988 (rank : 1724)
Query Neighborhood Hits	1931	Target Neighborhood Hits	161	Shared Neighborhood Hits	50
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

EMB_HUMAN
θ value	0.163984 (rank : 1209)	NC score	0.102387 (rank : 1164)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

HAX1_MOUSE
θ value	0.163984 (rank : 1210)	NC score	0.015629 (rank : 1608)
Query Neighborhood Hits	1931	Target Neighborhood Hits	27	Shared Neighborhood Hits	6
SwissProt Accessions	O35387	Gene names	Hax1, Hs1bp1
Domain Architecture	No domain graphic available
Description	HS1-associating protein X-1 (HAX-1) (HS1-binding protein).

HXB3_MOUSE
θ value	0.163984 (rank : 1211)	NC score	-0.009089 (rank : 2006)
Query Neighborhood Hits	1931	Target Neighborhood Hits	493	Shared Neighborhood Hits	89
SwissProt Accessions	P09026, P10285, Q4PJ06, Q61680	Gene names	Hoxb3, Hox-2.7, Hoxb-3
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2.7) (Homeobox protein MH-23).

ITSN1_HUMAN
θ value	0.163984 (rank : 1212)	NC score	0.080442 (rank : 1223)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1757	Shared Neighborhood Hits	277
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.163984 (rank : 1213)	NC score	0.080679 (rank : 1221)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1669	Shared Neighborhood Hits	255
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

LAG3_MOUSE
θ value	0.163984 (rank : 1214)	NC score	0.123954 (rank : 1113)
Query Neighborhood Hits	1931	Target Neighborhood Hits	117	Shared Neighborhood Hits	100
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

LCP2_HUMAN
θ value	0.163984 (rank : 1215)	NC score	0.059010 (rank : 1307)
Query Neighborhood Hits	1931	Target Neighborhood Hits	531	Shared Neighborhood Hits	194
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LRRN1_MOUSE
θ value	0.163984 (rank : 1216)	NC score	0.157109 (rank : 1072)
Query Neighborhood Hits	1931	Target Neighborhood Hits	508	Shared Neighborhood Hits	256
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

MAGE1_HUMAN
θ value	0.163984 (rank : 1217)	NC score	0.042009 (rank : 1386)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1389	Shared Neighborhood Hits	385
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PRP1_HUMAN
θ value	0.163984 (rank : 1218)	NC score	0.050713 (rank : 1355)
Query Neighborhood Hits	1931	Target Neighborhood Hits	385	Shared Neighborhood Hits	143
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

RTN4_HUMAN
θ value	0.163984 (rank : 1219)	NC score	0.021511 (rank : 1540)
Query Neighborhood Hits	1931	Target Neighborhood Hits	357	Shared Neighborhood Hits	90
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SC24C_HUMAN
θ value	0.163984 (rank : 1220)	NC score	0.036239 (rank : 1428)
Query Neighborhood Hits	1931	Target Neighborhood Hits	662	Shared Neighborhood Hits	239
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SEM3A_HUMAN
θ value	0.163984 (rank : 1221)	NC score	0.019363 (rank : 1565)
Query Neighborhood Hits	1931	Target Neighborhood Hits	78	Shared Neighborhood Hits	41
SwissProt Accessions	Q14563	Gene names	SEMA3A
Domain Architecture
Description	Semaphorin-3A precursor (Semaphorin III) (Sema III).

SEM3B_MOUSE
θ value	0.163984 (rank : 1222)	NC score	0.018942 (rank : 1575)
Query Neighborhood Hits	1931	Target Neighborhood Hits	75	Shared Neighborhood Hits	34
SwissProt Accessions	Q62177	Gene names	Sema3b, Sema, Semaa
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin A) (Sema A).

SIGL5_HUMAN
θ value	0.163984 (rank : 1223)	NC score	0.204132 (rank : 1027)
Query Neighborhood Hits	1931	Target Neighborhood Hits	246	Shared Neighborhood Hits	207
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

SMCA2_HUMAN
θ value	0.163984 (rank : 1224)	NC score	0.006912 (rank : 1751)
Query Neighborhood Hits	1931	Target Neighborhood Hits	503	Shared Neighborhood Hits	106
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

CD79B_MOUSE
θ value	0.21417 (rank : 1225)	NC score	0.040815 (rank : 1389)
Query Neighborhood Hits	1931	Target Neighborhood Hits	150	Shared Neighborhood Hits	57
SwissProt Accessions	P15530	Gene names	Cd79b, Igb
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

CEAM7_HUMAN
θ value	0.21417 (rank : 1226)	NC score	0.155393 (rank : 1074)
Query Neighborhood Hits	1931	Target Neighborhood Hits	170	Shared Neighborhood Hits	151
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

CJ078_MOUSE
θ value	0.21417 (rank : 1227)	NC score	0.030119 (rank : 1477)
Query Neighborhood Hits	1931	Target Neighborhood Hits	559	Shared Neighborhood Hits	127
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

G7C_HUMAN
θ value	0.21417 (rank : 1228)	NC score	0.033124 (rank : 1449)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y334, Q5SSR5, Q96QC8, Q9UMP9	Gene names	C6orf27, G7C, NG37
Domain Architecture	No domain graphic available
Description	Protein G7c precursor.

GR65_MOUSE
θ value	0.21417 (rank : 1229)	NC score	0.008933 (rank : 1706)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q91X51, Q9D3L9	Gene names	Gorasp1
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65).

IGS21_MOUSE
θ value	0.21417 (rank : 1230)	NC score	0.133879 (rank : 1104)
Query Neighborhood Hits	1931	Target Neighborhood Hits	118	Shared Neighborhood Hits	108
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

K1683_HUMAN
θ value	0.21417 (rank : 1231)	NC score	0.034591 (rank : 1438)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

KC1A_HUMAN
θ value	0.21417 (rank : 1232)	NC score	0.634679 (rank : 728)
Query Neighborhood Hits	1931	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	0.21417 (rank : 1233)	NC score	0.634679 (rank : 729)
Query Neighborhood Hits	1931	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

LRC41_HUMAN
θ value	0.21417 (rank : 1234)	NC score	0.011895 (rank : 1661)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	9
SwissProt Accessions	Q15345, Q71RA8, Q9BSM0	Gene names	LRRC41, MUF1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

LRRC4_MOUSE
θ value	0.21417 (rank : 1235)	NC score	0.102468 (rank : 1161)
Query Neighborhood Hits	1931	Target Neighborhood Hits	412	Shared Neighborhood Hits	174
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

MDC1_MOUSE
θ value	0.21417 (rank : 1236)	NC score	0.049148 (rank : 1364)
Query Neighborhood Hits	1931	Target Neighborhood Hits	998	Shared Neighborhood Hits	262
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

NOTC3_HUMAN
θ value	0.21417 (rank : 1237)	NC score	0.003480 (rank : 1812)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1062	Shared Neighborhood Hits	150
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

SEM4C_MOUSE
θ value	0.21417 (rank : 1238)	NC score	0.021941 (rank : 1538)
Query Neighborhood Hits	1931	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	Q64151	Gene names	Sema4c, Semacl1, Semai
Domain Architecture
Description	Semaphorin-4C precursor (Semaphorin I) (Sema I) (Semaphorin C-like 1) (M-Sema F).

SIGIR_HUMAN
θ value	0.21417 (rank : 1239)	NC score	0.043859 (rank : 1376)
Query Neighborhood Hits	1931	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	Q6IA17, Q3KQY2, Q6UXI3, Q9H733	Gene names	SIGIRR
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

STK23_MOUSE
θ value	0.21417 (rank : 1240)	NC score	0.512986 (rank : 814)
Query Neighborhood Hits	1931	Target Neighborhood Hits	572	Shared Neighborhood Hits	558
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

TAF4_HUMAN
θ value	0.21417 (rank : 1241)	NC score	0.046248 (rank : 1370)
Query Neighborhood Hits	1931	Target Neighborhood Hits	687	Shared Neighborhood Hits	198
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

VAV2_MOUSE
θ value	0.21417 (rank : 1242)	NC score	0.130386 (rank : 1109)
Query Neighborhood Hits	1931	Target Neighborhood Hits	456	Shared Neighborhood Hits	148
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ANPRA_HUMAN
θ value	0.279714 (rank : 1243)	NC score	0.412141 (rank : 860)
Query Neighborhood Hits	1931	Target Neighborhood Hits	612	Shared Neighborhood Hits	548
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

BCR_HUMAN
θ value	0.279714 (rank : 1244)	NC score	0.048887 (rank : 1365)
Query Neighborhood Hits	1931	Target Neighborhood Hits	204	Shared Neighborhood Hits	72
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CSTFT_MOUSE
θ value	0.279714 (rank : 1245)	NC score	0.001058 (rank : 1881)
Query Neighborhood Hits	1931	Target Neighborhood Hits	356	Shared Neighborhood Hits	70
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

DAB1_HUMAN
θ value	0.279714 (rank : 1246)	NC score	0.014856 (rank : 1616)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	96
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

DEDD2_HUMAN
θ value	0.279714 (rank : 1247)	NC score	0.008581 (rank : 1715)
Query Neighborhood Hits	1931	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXF8, Q8NBR2, Q8NES1, Q8TAA8, Q96D35	Gene names	DEDD2, FLAME3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

EVPL_HUMAN
θ value	0.279714 (rank : 1248)	NC score	0.013706 (rank : 1628)
Query Neighborhood Hits	1931	Target Neighborhood Hits	895	Shared Neighborhood Hits	95
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

FYCO1_HUMAN
θ value	0.279714 (rank : 1249)	NC score	0.013189 (rank : 1637)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1149	Shared Neighborhood Hits	116
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

IGS21_HUMAN
θ value	0.279714 (rank : 1250)	NC score	0.133356 (rank : 1105)
Query Neighborhood Hits	1931	Target Neighborhood Hits	123	Shared Neighborhood Hits	109
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

INVS_HUMAN
θ value	0.279714 (rank : 1251)	NC score	0.013132 (rank : 1638)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

INVS_MOUSE
θ value	0.279714 (rank : 1252)	NC score	0.015218 (rank : 1613)
Query Neighborhood Hits	1931	Target Neighborhood Hits	609	Shared Neighborhood Hits	139
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

JAML1_HUMAN
θ value	0.279714 (rank : 1253)	NC score	0.068168 (rank : 1265)
Query Neighborhood Hits	1931	Target Neighborhood Hits	108	Shared Neighborhood Hits	78
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

KC1AL_HUMAN
θ value	0.279714 (rank : 1254)	NC score	0.630946 (rank : 734)
Query Neighborhood Hits	1931	Target Neighborhood Hits	734	Shared Neighborhood Hits	728
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

PAX1_HUMAN
θ value	0.279714 (rank : 1255)	NC score	0.006198 (rank : 1767)
Query Neighborhood Hits	1931	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	P15863, Q642X9, Q6NTC0, Q9Y558	Gene names	PAX1, HUP48
Domain Architecture
Description	Paired box protein Pax-1 (HUP48).

PDL2_MOUSE
θ value	0.279714 (rank : 1256)	NC score	0.122909 (rank : 1118)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	100
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

RN5A_MOUSE
θ value	0.279714 (rank : 1257)	NC score	0.308771 (rank : 967)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	614
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

SEM4D_MOUSE
θ value	0.279714 (rank : 1258)	NC score	0.027860 (rank : 1499)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	69
SwissProt Accessions	O09126	Gene names	Sema4d, Semacl2, Semaj
Domain Architecture
Description	Semaphorin-4D precursor (Semaphorin J) (Sema J) (Semaphorin C-like 2) (M-Sema G).

TCGAP_HUMAN
θ value	0.279714 (rank : 1259)	NC score	0.025035 (rank : 1516)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	262
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TRI47_MOUSE
θ value	0.279714 (rank : 1260)	NC score	-0.003596 (rank : 1959)
Query Neighborhood Hits	1931	Target Neighborhood Hits	295	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRIM9_HUMAN
θ value	0.279714 (rank : 1261)	NC score	0.026259 (rank : 1508)
Query Neighborhood Hits	1931	Target Neighborhood Hits	294	Shared Neighborhood Hits	63
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

WASP_HUMAN
θ value	0.279714 (rank : 1262)	NC score	0.029039 (rank : 1488)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	87
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

ZN687_HUMAN
θ value	0.279714 (rank : 1263)	NC score	-0.010478 (rank : 2009)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1244	Shared Neighborhood Hits	250
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

2B32_HUMAN
θ value	0.365318 (rank : 1264)	NC score	0.001923 (rank : 1854)
Query Neighborhood Hits	1931	Target Neighborhood Hits	207	Shared Neighborhood Hits	36
SwissProt Accessions	P01913, O78049, P79663, Q29721, Q29809, Q30144, Q9MYA4, Q9MYH3, Q9MYH4, Q9TPB5, Q9TQ21	Gene names	HLA-DRB3
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB3-2 beta chain precursor (MHC class I antigen DRB3*2).

ACV1B_HUMAN
θ value	0.365318 (rank : 1265)	NC score	0.582081 (rank : 790)
Query Neighborhood Hits	1931	Target Neighborhood Hits	753	Shared Neighborhood Hits	750
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	0.365318 (rank : 1266)	NC score	0.582188 (rank : 789)
Query Neighborhood Hits	1931	Target Neighborhood Hits	753	Shared Neighborhood Hits	749
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

APXL_HUMAN
θ value	0.365318 (rank : 1267)	NC score	0.032755 (rank : 1456)
Query Neighborhood Hits	1931	Target Neighborhood Hits	553	Shared Neighborhood Hits	131
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARI1B_HUMAN
θ value	0.365318 (rank : 1268)	NC score	0.031715 (rank : 1461)
Query Neighborhood Hits	1931	Target Neighborhood Hits	567	Shared Neighborhood Hits	185
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

CNTFR_HUMAN
θ value	0.365318 (rank : 1269)	NC score	0.035602 (rank : 1432)
Query Neighborhood Hits	1931	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CSKI1_HUMAN
θ value	0.365318 (rank : 1270)	NC score	0.036311 (rank : 1427)
Query Neighborhood Hits	1931	Target Neighborhood Hits	997	Shared Neighborhood Hits	289
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ENAH_MOUSE
θ value	0.365318 (rank : 1271)	NC score	0.038139 (rank : 1410)
Query Neighborhood Hits	1931	Target Neighborhood Hits	919	Shared Neighborhood Hits	208
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

GP113_HUMAN
θ value	0.365318 (rank : 1272)	NC score	-0.000703 (rank : 1916)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IZF5, Q6UXT7, Q6UXX3, Q86SL7, Q8IXD8, Q8TDT3	Gene names	GPR113, PGR23
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 113 precursor (G-protein coupled receptor PGR23).

HB2P_HUMAN
θ value	0.365318 (rank : 1273)	NC score	-0.000127 (rank : 1903)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	36
SwissProt Accessions	P04440, O19698, O19700, O19702	Gene names	HLA-DPB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DP(W4) beta chain precursor.

HB2Q_HUMAN
θ value	0.365318 (rank : 1274)	NC score	-0.000333 (rank : 1910)
Query Neighborhood Hits	1931	Target Neighborhood Hits	212	Shared Neighborhood Hits	36
SwissProt Accessions	P13763	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DP(W2) beta chain precursor (SB-2-beta).

HV07_MOUSE
θ value	0.365318 (rank : 1275)	NC score	-0.001238 (rank : 1927)
Query Neighborhood Hits	1931	Target Neighborhood Hits	246	Shared Neighborhood Hits	51
SwissProt Accessions	P01751, P01752	Gene names
Domain Architecture
Description	Ig heavy chain V region B1-8/186-2 precursor.

HV09_MOUSE
θ value	0.365318 (rank : 1276)	NC score	-0.001447 (rank : 1933)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	P01753, P11271	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region 186-1 precursor.

HV11_MOUSE
θ value	0.365318 (rank : 1277)	NC score	-0.001105 (rank : 1926)
Query Neighborhood Hits	1931	Target Neighborhood Hits	239	Shared Neighborhood Hits	48
SwissProt Accessions	P01755	Gene names
Domain Architecture
Description	Ig heavy chain V region S43 precursor.

HXB3_HUMAN
θ value	0.365318 (rank : 1278)	NC score	-0.008361 (rank : 2004)
Query Neighborhood Hits	1931	Target Neighborhood Hits	559	Shared Neighborhood Hits	118
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

IL12B_HUMAN
θ value	0.365318 (rank : 1279)	NC score	0.035134 (rank : 1435)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	34
SwissProt Accessions	P29460	Gene names	IL12B, NKSF2
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (NK cell stimulatory factor chain 2) (NKSF2).

IL12B_MOUSE
θ value	0.365318 (rank : 1280)	NC score	0.040767 (rank : 1390)
Query Neighborhood Hits	1931	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	P43432, Q9QUM1	Gene names	Il12b
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40).

IRAK3_HUMAN
θ value	0.365318 (rank : 1281)	NC score	0.578770 (rank : 794)
Query Neighborhood Hits	1931	Target Neighborhood Hits	644	Shared Neighborhood Hits	631
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

LV2J_HUMAN
θ value	0.365318 (rank : 1282)	NC score	-0.004268 (rank : 1971)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	P01713	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region NIG-58.

MBD6_HUMAN
θ value	0.365318 (rank : 1283)	NC score	0.045212 (rank : 1374)
Query Neighborhood Hits	1931	Target Neighborhood Hits	349	Shared Neighborhood Hits	131
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

MKL1_MOUSE
θ value	0.365318 (rank : 1284)	NC score	0.025948 (rank : 1510)
Query Neighborhood Hits	1931	Target Neighborhood Hits	667	Shared Neighborhood Hits	218
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

MLL4_HUMAN
θ value	0.365318 (rank : 1285)	NC score	0.019360 (rank : 1566)
Query Neighborhood Hits	1931	Target Neighborhood Hits	722	Shared Neighborhood Hits	167
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MOX2R_MOUSE
θ value	0.365318 (rank : 1286)	NC score	0.147161 (rank : 1081)
Query Neighborhood Hits	1931	Target Neighborhood Hits	110	Shared Neighborhood Hits	101
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MTR1L_HUMAN
θ value	0.365318 (rank : 1287)	NC score	-0.026338 (rank : 2048)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1180	Shared Neighborhood Hits	105
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

PER1_HUMAN
θ value	0.365318 (rank : 1288)	NC score	0.010381 (rank : 1681)
Query Neighborhood Hits	1931	Target Neighborhood Hits	215	Shared Neighborhood Hits	69
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PRPC_HUMAN
θ value	0.365318 (rank : 1289)	NC score	0.030756 (rank : 1470)
Query Neighborhood Hits	1931	Target Neighborhood Hits	165	Shared Neighborhood Hits	60
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

PSD4_HUMAN
θ value	0.365318 (rank : 1290)	NC score	0.014825 (rank : 1618)
Query Neighborhood Hits	1931	Target Neighborhood Hits	178	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

PSL1_HUMAN
θ value	0.365318 (rank : 1291)	NC score	0.036715 (rank : 1422)
Query Neighborhood Hits	1931	Target Neighborhood Hits	650	Shared Neighborhood Hits	243
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

TENR_HUMAN
θ value	0.365318 (rank : 1292)	NC score	0.087121 (rank : 1198)
Query Neighborhood Hits	1931	Target Neighborhood Hits	526	Shared Neighborhood Hits	151
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

TPSNR_HUMAN
θ value	0.365318 (rank : 1293)	NC score	0.063794 (rank : 1288)
Query Neighborhood Hits	1931	Target Neighborhood Hits	330	Shared Neighborhood Hits	136
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

UNC5D_HUMAN
θ value	0.365318 (rank : 1294)	NC score	0.155929 (rank : 1073)
Query Neighborhood Hits	1931	Target Neighborhood Hits	267	Shared Neighborhood Hits	186
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
θ value	0.365318 (rank : 1295)	NC score	0.157541 (rank : 1071)
Query Neighborhood Hits	1931	Target Neighborhood Hits	268	Shared Neighborhood Hits	187
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

USH2A_HUMAN
θ value	0.365318 (rank : 1296)	NC score	0.132041 (rank : 1107)
Query Neighborhood Hits	1931	Target Neighborhood Hits	600	Shared Neighborhood Hits	174
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

VRK3_HUMAN
θ value	0.365318 (rank : 1297)	NC score	0.255797 (rank : 1000)
Query Neighborhood Hits	1931	Target Neighborhood Hits	349	Shared Neighborhood Hits	317
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

ALX4_HUMAN
θ value	0.47712 (rank : 1298)	NC score	-0.012862 (rank : 2013)
Query Neighborhood Hits	1931	Target Neighborhood Hits	394	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H161, Q96JN7, Q9H198, Q9HAY9	Gene names	ALX4, KIAA1788
Domain Architecture
Description	Homeobox protein aristaless-like 4.

CD2_HUMAN
θ value	0.47712 (rank : 1299)	NC score	0.037432 (rank : 1417)
Query Neighborhood Hits	1931	Target Neighborhood Hits	504	Shared Neighborhood Hits	177
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

COCA1_HUMAN
θ value	0.47712 (rank : 1300)	NC score	0.115380 (rank : 1131)
Query Neighborhood Hits	1931	Target Neighborhood Hits	458	Shared Neighborhood Hits	209
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COFA1_HUMAN
θ value	0.47712 (rank : 1301)	NC score	0.012558 (rank : 1649)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	98
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

CS007_MOUSE
θ value	0.47712 (rank : 1302)	NC score	0.020457 (rank : 1547)
Query Neighborhood Hits	1931	Target Neighborhood Hits	464	Shared Neighborhood Hits	136
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

GPS2_HUMAN
θ value	0.47712 (rank : 1303)	NC score	0.037664 (rank : 1415)
Query Neighborhood Hits	1931	Target Neighborhood Hits	459	Shared Neighborhood Hits	116
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

IASPP_HUMAN
θ value	0.47712 (rank : 1304)	NC score	0.039692 (rank : 1400)
Query Neighborhood Hits	1931	Target Neighborhood Hits	688	Shared Neighborhood Hits	187
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

KCNN3_MOUSE
θ value	0.47712 (rank : 1305)	NC score	0.002344 (rank : 1843)
Query Neighborhood Hits	1931	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	P58391	Gene names	Kcnn3, Sk3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3).

MUCB_HUMAN
θ value	0.47712 (rank : 1306)	NC score	0.019654 (rank : 1556)
Query Neighborhood Hits	1931	Target Neighborhood Hits	233	Shared Neighborhood Hits	59
SwissProt Accessions	P04220	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu heavy chain disease protein (BOT).

MUCDL_HUMAN
θ value	0.47712 (rank : 1307)	NC score	0.022420 (rank : 1532)
Query Neighborhood Hits	1931	Target Neighborhood Hits	777	Shared Neighborhood Hits	230
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

MUC_HUMAN
θ value	0.47712 (rank : 1308)	NC score	0.019587 (rank : 1558)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	58
SwissProt Accessions	P01871	Gene names	IGHM
Domain Architecture
Description	Ig mu chain C region.

MY18B_HUMAN
θ value	0.47712 (rank : 1309)	NC score	0.018994 (rank : 1574)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1299	Shared Neighborhood Hits	198
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

NCOA3_MOUSE
θ value	0.47712 (rank : 1310)	NC score	0.004470 (rank : 1795)
Query Neighborhood Hits	1931	Target Neighborhood Hits	203	Shared Neighborhood Hits	56
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

PKHA6_HUMAN
θ value	0.47712 (rank : 1311)	NC score	0.027443 (rank : 1501)
Query Neighborhood Hits	1931	Target Neighborhood Hits	556	Shared Neighborhood Hits	152
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

RREB1_HUMAN
θ value	0.47712 (rank : 1312)	NC score	-0.021719 (rank : 2028)
Query Neighborhood Hits	1931	Target Neighborhood Hits	879	Shared Neighborhood Hits	95
SwissProt Accessions	Q92766, O75567	Gene names	RREB1
Domain Architecture
Description	RAS-responsive element-binding protein 1 (RREB-1) (Raf-responsive zinc finger protein LZ321).

SEM3C_MOUSE
θ value	0.47712 (rank : 1313)	NC score	0.029938 (rank : 1480)
Query Neighborhood Hits	1931	Target Neighborhood Hits	113	Shared Neighborhood Hits	70
SwissProt Accessions	Q62181	Gene names	Sema3c, Semae, SemE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

SEM4B_HUMAN
θ value	0.47712 (rank : 1314)	NC score	0.014704 (rank : 1620)
Query Neighborhood Hits	1931	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NPR2, Q6UXE3, Q8WVP9, Q96FK5, Q9C0B8, Q9H691, Q9NPM8, Q9NPN0	Gene names	SEMA4B, KIAA1745
Domain Architecture
Description	Semaphorin-4B precursor.

SF3B2_HUMAN
θ value	0.47712 (rank : 1315)	NC score	0.030754 (rank : 1471)
Query Neighborhood Hits	1931	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

SF3B4_HUMAN
θ value	0.47712 (rank : 1316)	NC score	0.001840 (rank : 1857)
Query Neighborhood Hits	1931	Target Neighborhood Hits	445	Shared Neighborhood Hits	101
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

SYN3_MOUSE
θ value	0.47712 (rank : 1317)	NC score	0.022355 (rank : 1533)
Query Neighborhood Hits	1931	Target Neighborhood Hits	200	Shared Neighborhood Hits	76
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

TAF5_HUMAN
θ value	0.47712 (rank : 1318)	NC score	-0.016217 (rank : 2022)
Query Neighborhood Hits	1931	Target Neighborhood Hits	352	Shared Neighborhood Hits	13
SwissProt Accessions	Q15542, Q86UZ7, Q9Y4K5	Gene names	TAF5, TAF2D
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

TENS1_HUMAN
θ value	0.47712 (rank : 1319)	NC score	0.034426 (rank : 1440)
Query Neighborhood Hits	1931	Target Neighborhood Hits	400	Shared Neighborhood Hits	131
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

TNR4_HUMAN
θ value	0.47712 (rank : 1320)	NC score	0.011645 (rank : 1665)
Query Neighborhood Hits	1931	Target Neighborhood Hits	152	Shared Neighborhood Hits	34
SwissProt Accessions	P43489, Q13663, Q5T7M0	Gene names	TNFRSF4, TXGP1L
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (ACT35 antigen) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD134 antigen).

TRML1_HUMAN
θ value	0.47712 (rank : 1321)	NC score	0.023041 (rank : 1530)
Query Neighborhood Hits	1931	Target Neighborhood Hits	33	Shared Neighborhood Hits	18
SwissProt Accessions	Q86YW5, Q496B3, Q8IWY1, Q8IWY2	Gene names	TREML1, TLT1
Domain Architecture	No domain graphic available
Description	Trem-like transcript 1 protein precursor (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1).

ZN546_HUMAN
θ value	0.47712 (rank : 1322)	NC score	-0.026162 (rank : 2047)
Query Neighborhood Hits	1931	Target Neighborhood Hits	772	Shared Neighborhood Hits	49
SwissProt Accessions	Q86UE3	Gene names	ZNF546, ZNF49
Domain Architecture	No domain graphic available
Description	Zinc finger protein 546.

2B11_HUMAN
θ value	0.62314 (rank : 1323)	NC score	0.001435 (rank : 1867)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	40
SwissProt Accessions	P04229, O62869, P13758, Q06662, Q30116, Q30117, Q95461, Q9BCL7, Q9GIK5, Q9MXZ0, Q9MXZ5, Q9TQ91	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-1 beta chain precursor (MHC class I antigen DRB1*1) (DR-1) (DR1).

2B18_HUMAN
θ value	0.62314 (rank : 1324)	NC score	0.001573 (rank : 1865)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	38
SwissProt Accessions	Q30134, O19718, O19788, Q29968, Q30108, Q30115, Q9BCP0, Q9BCP1, Q9BCP2, Q9BD33, Q9TQ37, Q9UIM9	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-8 beta chain precursor (MHC class I antigen DRB1*8) (DR-8) (DR8) (DRw8).

2B1B_HUMAN
θ value	0.62314 (rank : 1325)	NC score	0.001693 (rank : 1864)
Query Neighborhood Hits	1931	Target Neighborhood Hits	208	Shared Neighborhood Hits	40
SwissProt Accessions	P20039, Q30006, Q9GIX8	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-11 beta chain precursor (MHC class I antigen DRB1*11) (DR-5) (DR5) (DRw11).

2B31_HUMAN
θ value	0.62314 (rank : 1326)	NC score	0.002043 (rank : 1852)
Query Neighborhood Hits	1931	Target Neighborhood Hits	207	Shared Neighborhood Hits	38
SwissProt Accessions	P79483, Q95359, Q96H16	Gene names	HLA-DRB3
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB3-1 beta chain precursor (MHC class I antigen DRB3*1).

ACVL1_MOUSE
θ value	0.62314 (rank : 1327)	NC score	0.563538 (rank : 799)
Query Neighborhood Hits	1931	Target Neighborhood Hits	739	Shared Neighborhood Hits	736
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

CD79B_HUMAN
θ value	0.62314 (rank : 1328)	NC score	0.033756 (rank : 1445)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	66
SwissProt Accessions	P40259, Q9BU06	Gene names	CD79B, B29, IGB
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

CN032_HUMAN
θ value	0.62314 (rank : 1329)	NC score	0.028132 (rank : 1496)
Query Neighborhood Hits	1931	Target Neighborhood Hits	267	Shared Neighborhood Hits	94
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

CO1A1_HUMAN
θ value	0.62314 (rank : 1330)	NC score	0.013924 (rank : 1624)
Query Neighborhood Hits	1931	Target Neighborhood Hits	475	Shared Neighborhood Hits	146
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CRSP7_HUMAN
θ value	0.62314 (rank : 1331)	NC score	0.023973 (rank : 1525)
Query Neighborhood Hits	1931	Target Neighborhood Hits	247	Shared Neighborhood Hits	91
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

CT075_HUMAN
θ value	0.62314 (rank : 1332)	NC score	0.075826 (rank : 1238)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	129
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

GP125_HUMAN
θ value	0.62314 (rank : 1333)	NC score	0.040126 (rank : 1393)
Query Neighborhood Hits	1931	Target Neighborhood Hits	327	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IWK6, Q6UXK9, Q86SQ5, Q8TC55	Gene names	GPR125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

GP125_MOUSE
θ value	0.62314 (rank : 1334)	NC score	0.042332 (rank : 1384)
Query Neighborhood Hits	1931	Target Neighborhood Hits	329	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

HB2B_HUMAN
θ value	0.62314 (rank : 1335)	NC score	0.002431 (rank : 1838)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	41
SwissProt Accessions	P01912	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DR-1 beta chain precursor (Clone P2-beta-3).

HV49_MOUSE
θ value	0.62314 (rank : 1336)	NC score	-0.000188 (rank : 1906)
Query Neighborhood Hits	1931	Target Neighborhood Hits	232	Shared Neighborhood Hits	44
SwissProt Accessions	P06328	Gene names
Domain Architecture
Description	Ig heavy chain V region VH558 B4 precursor.

HXA3_HUMAN
θ value	0.62314 (rank : 1337)	NC score	-0.007139 (rank : 2001)
Query Neighborhood Hits	1931	Target Neighborhood Hits	535	Shared Neighborhood Hits	89
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

HXA3_MOUSE
θ value	0.62314 (rank : 1338)	NC score	-0.007036 (rank : 2000)
Query Neighborhood Hits	1931	Target Neighborhood Hits	558	Shared Neighborhood Hits	105
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

K1802_HUMAN
θ value	0.62314 (rank : 1339)	NC score	0.017524 (rank : 1589)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1378	Shared Neighborhood Hits	273
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MADCA_HUMAN
θ value	0.62314 (rank : 1340)	NC score	0.042683 (rank : 1381)
Query Neighborhood Hits	1931	Target Neighborhood Hits	221	Shared Neighborhood Hits	78
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MAML3_HUMAN
θ value	0.62314 (rank : 1341)	NC score	0.023175 (rank : 1528)
Query Neighborhood Hits	1931	Target Neighborhood Hits	323	Shared Neighborhood Hits	117
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

MYO15_MOUSE
θ value	0.62314 (rank : 1342)	NC score	0.016505 (rank : 1602)
Query Neighborhood Hits	1931	Target Neighborhood Hits	467	Shared Neighborhood Hits	162
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

PDLI4_HUMAN
θ value	0.62314 (rank : 1343)	NC score	0.003719 (rank : 1808)
Query Neighborhood Hits	1931	Target Neighborhood Hits	245	Shared Neighborhood Hits	34
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

PRB4S_HUMAN
θ value	0.62314 (rank : 1344)	NC score	0.048160 (rank : 1367)
Query Neighborhood Hits	1931	Target Neighborhood Hits	330	Shared Neighborhood Hits	124
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PTPRN_HUMAN
θ value	0.62314 (rank : 1345)	NC score	0.020398 (rank : 1549)
Query Neighborhood Hits	1931	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

PVRL3_MOUSE
θ value	0.62314 (rank : 1346)	NC score	0.172858 (rank : 1051)
Query Neighborhood Hits	1931	Target Neighborhood Hits	212	Shared Neighborhood Hits	173
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

RERE_HUMAN
θ value	0.62314 (rank : 1347)	NC score	0.031194 (rank : 1463)
Query Neighborhood Hits	1931	Target Neighborhood Hits	779	Shared Neighborhood Hits	212
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

REXO1_MOUSE
θ value	0.62314 (rank : 1348)	NC score	0.009157 (rank : 1701)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

RFX1_HUMAN
θ value	0.62314 (rank : 1349)	NC score	0.018495 (rank : 1578)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	89
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

RP1L1_HUMAN
θ value	0.62314 (rank : 1350)	NC score	0.039701 (rank : 1399)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1072	Shared Neighborhood Hits	238
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SEM3C_HUMAN
θ value	0.62314 (rank : 1351)	NC score	0.027669 (rank : 1500)
Query Neighborhood Hits	1931	Target Neighborhood Hits	106	Shared Neighborhood Hits	66
SwissProt Accessions	Q99985	Gene names	SEMA3C, SEMAE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

SMCA4_HUMAN
θ value	0.62314 (rank : 1352)	NC score	0.016174 (rank : 1603)
Query Neighborhood Hits	1931	Target Neighborhood Hits	597	Shared Neighborhood Hits	157
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

SPTN2_HUMAN
θ value	0.62314 (rank : 1353)	NC score	0.004308 (rank : 1796)
Query Neighborhood Hits	1931	Target Neighborhood Hits	535	Shared Neighborhood Hits	76
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

SRRM2_MOUSE
θ value	0.62314 (rank : 1354)	NC score	0.069927 (rank : 1258)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1470	Shared Neighborhood Hits	342
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

SYNPO_MOUSE
θ value	0.62314 (rank : 1355)	NC score	0.025615 (rank : 1511)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	85
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TENR_MOUSE
θ value	0.62314 (rank : 1356)	NC score	0.083707 (rank : 1209)
Query Neighborhood Hits	1931	Target Neighborhood Hits	531	Shared Neighborhood Hits	146
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

WDR33_HUMAN
θ value	0.62314 (rank : 1357)	NC score	-0.003744 (rank : 1963)
Query Neighborhood Hits	1931	Target Neighborhood Hits	638	Shared Neighborhood Hits	131
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

ZNF91_HUMAN
θ value	0.62314 (rank : 1358)	NC score	-0.025620 (rank : 2037)
Query Neighborhood Hits	1931	Target Neighborhood Hits	797	Shared Neighborhood Hits	56
SwissProt Accessions	Q05481	Gene names	ZNF91
Domain Architecture
Description	Zinc finger protein 91 (Zinc finger protein HTF10) (HPF7).

2DMA_MOUSE
θ value	0.813845 (rank : 1359)	NC score	0.002400 (rank : 1841)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	P28078	Gene names	H2-DMa, H2-Ma, Ma
Domain Architecture
Description	Class II histocompatibility antigen, M alpha chain precursor.

ACD_HUMAN
θ value	0.813845 (rank : 1360)	NC score	0.021207 (rank : 1542)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	50
SwissProt Accessions	Q96AP0, Q562H5, Q9H8F9	Gene names	ACD, PIP1, PTOP
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein).

ACVL1_HUMAN
θ value	0.813845 (rank : 1361)	NC score	0.542725 (rank : 803)
Query Neighborhood Hits	1931	Target Neighborhood Hits	716	Shared Neighborhood Hits	711
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

AFF1_MOUSE
θ value	0.813845 (rank : 1362)	NC score	0.020492 (rank : 1546)
Query Neighborhood Hits	1931	Target Neighborhood Hits	351	Shared Neighborhood Hits	81
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

AIPL1_HUMAN
θ value	0.813845 (rank : 1363)	NC score	0.002658 (rank : 1833)
Query Neighborhood Hits	1931	Target Neighborhood Hits	113	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZN9, Q9H873, Q9NS10	Gene names	AIPL1
Domain Architecture
Description	Aryl-hydrocarbon-interacting protein-like 1.

ANXA7_MOUSE
θ value	0.813845 (rank : 1364)	NC score	0.000928 (rank : 1883)
Query Neighborhood Hits	1931	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q07076	Gene names	Anxa7, Anx7
Domain Architecture
Description	Annexin A7 (Annexin VII) (Synexin).

CCDC9_HUMAN
θ value	0.813845 (rank : 1365)	NC score	0.013805 (rank : 1627)
Query Neighborhood Hits	1931	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

CHD9_MOUSE
θ value	0.813845 (rank : 1366)	NC score	0.006843 (rank : 1752)
Query Neighborhood Hits	1931	Target Neighborhood Hits	427	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

CIC_HUMAN
θ value	0.813845 (rank : 1367)	NC score	0.034386 (rank : 1441)
Query Neighborhood Hits	1931	Target Neighborhood Hits	992	Shared Neighborhood Hits	296
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CO002_HUMAN
θ value	0.813845 (rank : 1368)	NC score	0.027947 (rank : 1498)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

CO4A3_HUMAN
θ value	0.813845 (rank : 1369)	NC score	0.010171 (rank : 1688)
Query Neighborhood Hits	1931	Target Neighborhood Hits	421	Shared Neighborhood Hits	146
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

DACH1_HUMAN
θ value	0.813845 (rank : 1370)	NC score	0.007734 (rank : 1733)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

DRD4_HUMAN
θ value	0.813845 (rank : 1371)	NC score	-0.024543 (rank : 2033)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	P21917	Gene names	DRD4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).

F100A_MOUSE
θ value	0.813845 (rank : 1372)	NC score	0.009608 (rank : 1693)
Query Neighborhood Hits	1931	Target Neighborhood Hits	26	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P3B2	Gene names	Fam100a
Domain Architecture	No domain graphic available
Description	Protein FAM100A.

FOG1_HUMAN
θ value	0.813845 (rank : 1373)	NC score	-0.014466 (rank : 2018)
Query Neighborhood Hits	1931	Target Neighborhood Hits	981	Shared Neighborhood Hits	146
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

GLIS3_MOUSE
θ value	0.813845 (rank : 1374)	NC score	-0.022730 (rank : 2030)
Query Neighborhood Hits	1931	Target Neighborhood Hits	861	Shared Neighborhood Hits	110
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

HPLN2_HUMAN
θ value	0.813845 (rank : 1375)	NC score	0.018177 (rank : 1581)
Query Neighborhood Hits	1931	Target Neighborhood Hits	80	Shared Neighborhood Hits	47
SwissProt Accessions	Q9GZV7	Gene names	HAPLN2, BRAL1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

HPLN2_MOUSE
θ value	0.813845 (rank : 1376)	NC score	0.026826 (rank : 1506)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ESM3	Gene names	Hapln2, Bral1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

IL6RA_MOUSE
θ value	0.813845 (rank : 1377)	NC score	0.063854 (rank : 1285)
Query Neighborhood Hits	1931	Target Neighborhood Hits	104	Shared Neighborhood Hits	74
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

IRX5_HUMAN
θ value	0.813845 (rank : 1378)	NC score	0.003655 (rank : 1811)
Query Neighborhood Hits	1931	Target Neighborhood Hits	362	Shared Neighborhood Hits	74
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

LEPR_HUMAN
θ value	0.813845 (rank : 1379)	NC score	0.032871 (rank : 1455)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	61
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

LV2F_HUMAN
θ value	0.813845 (rank : 1380)	NC score	-0.003969 (rank : 1966)
Query Neighborhood Hits	1931	Target Neighborhood Hits	253	Shared Neighborhood Hits	53
SwissProt Accessions	P01709	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region MGC.

MFAP3_HUMAN
θ value	0.813845 (rank : 1381)	NC score	0.091942 (rank : 1188)
Query Neighborhood Hits	1931	Target Neighborhood Hits	91	Shared Neighborhood Hits	84
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MLL3_MOUSE
θ value	0.813845 (rank : 1382)	NC score	0.027981 (rank : 1497)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1399	Shared Neighborhood Hits	306
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MORC3_HUMAN
θ value	0.813845 (rank : 1383)	NC score	0.007746 (rank : 1732)
Query Neighborhood Hits	1931	Target Neighborhood Hits	489	Shared Neighborhood Hits	44
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

NCOR2_HUMAN
θ value	0.813845 (rank : 1384)	NC score	0.040137 (rank : 1392)
Query Neighborhood Hits	1931	Target Neighborhood Hits	870	Shared Neighborhood Hits	240
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NSD1_MOUSE
θ value	0.813845 (rank : 1385)	NC score	0.008685 (rank : 1712)
Query Neighborhood Hits	1931	Target Neighborhood Hits	472	Shared Neighborhood Hits	102
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PDZD2_HUMAN
θ value	0.813845 (rank : 1386)	NC score	0.017568 (rank : 1588)
Query Neighborhood Hits	1931	Target Neighborhood Hits	772	Shared Neighborhood Hits	189
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PRR12_HUMAN
θ value	0.813845 (rank : 1387)	NC score	0.039225 (rank : 1404)
Query Neighborhood Hits	1931	Target Neighborhood Hits	460	Shared Neighborhood Hits	136
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

PTPRT_HUMAN
θ value	0.813845 (rank : 1388)	NC score	0.090986 (rank : 1193)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	121
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PVRL2_HUMAN
θ value	0.813845 (rank : 1389)	NC score	0.126540 (rank : 1110)
Query Neighborhood Hits	1931	Target Neighborhood Hits	185	Shared Neighborhood Hits	136
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

RGP2_HUMAN
θ value	0.813845 (rank : 1390)	NC score	0.005547 (rank : 1777)
Query Neighborhood Hits	1931	Target Neighborhood Hits	60	Shared Neighborhood Hits	19
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

RGS3_MOUSE
θ value	0.813845 (rank : 1391)	NC score	0.057918 (rank : 1313)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1621	Shared Neighborhood Hits	433
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TOPB1_MOUSE
θ value	0.813845 (rank : 1392)	NC score	0.007253 (rank : 1743)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).

TTDN1_MOUSE
θ value	0.813845 (rank : 1393)	NC score	0.017253 (rank : 1593)
Query Neighborhood Hits	1931	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D011	Gene names	Ttdn1
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein homolog.

2B17_HUMAN
θ value	1.06291 (rank : 1394)	NC score	0.001200 (rank : 1879)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	P13761, O46699, O46872	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-7 beta chain precursor (MHC class I antigen DRB1*7) (DR-7) (DR7).

2B19_HUMAN
θ value	1.06291 (rank : 1395)	NC score	0.001288 (rank : 1875)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	38
SwissProt Accessions	Q9TQE0, Q30149	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-9 beta chain precursor (MHC class I antigen DRB1*9) (DR-9) (DR9).

ALEX_HUMAN
θ value	1.06291 (rank : 1396)	NC score	0.035330 (rank : 1433)
Query Neighborhood Hits	1931	Target Neighborhood Hits	361	Shared Neighborhood Hits	125
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

BASP_MOUSE
θ value	1.06291 (rank : 1397)	NC score	0.042616 (rank : 1383)
Query Neighborhood Hits	1931	Target Neighborhood Hits	260	Shared Neighborhood Hits	74
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BMR1B_HUMAN
θ value	1.06291 (rank : 1398)	NC score	0.580304 (rank : 792)
Query Neighborhood Hits	1931	Target Neighborhood Hits	760	Shared Neighborhood Hits	749
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	1.06291 (rank : 1399)	NC score	0.581935 (rank : 791)
Query Neighborhood Hits	1931	Target Neighborhood Hits	758	Shared Neighborhood Hits	750
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BRD8_MOUSE
θ value	1.06291 (rank : 1400)	NC score	0.010707 (rank : 1677)
Query Neighborhood Hits	1931	Target Neighborhood Hits	422	Shared Neighborhood Hits	90
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

CN155_HUMAN
θ value	1.06291 (rank : 1401)	NC score	0.038045 (rank : 1411)
Query Neighborhood Hits	1931	Target Neighborhood Hits	385	Shared Neighborhood Hits	104
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

COFA1_MOUSE
θ value	1.06291 (rank : 1402)	NC score	0.009924 (rank : 1689)
Query Neighborhood Hits	1931	Target Neighborhood Hits	305	Shared Neighborhood Hits	108
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

DREB_MOUSE
θ value	1.06291 (rank : 1403)	NC score	0.025214 (rank : 1512)
Query Neighborhood Hits	1931	Target Neighborhood Hits	446	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

EMID2_HUMAN
θ value	1.06291 (rank : 1404)	NC score	0.011876 (rank : 1662)
Query Neighborhood Hits	1931	Target Neighborhood Hits	226	Shared Neighborhood Hits	91
SwissProt Accessions	Q96A83	Gene names	EMID2, COL26A1, EMU2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

FREA_HUMAN
θ value	1.06291 (rank : 1405)	NC score	-0.004288 (rank : 1972)
Query Neighborhood Hits	1931	Target Neighborhood Hits	205	Shared Neighborhood Hits	64
SwissProt Accessions	O43638, Q96D28	Gene names	FKHL18, FREAC10
Domain Architecture	No domain graphic available
Description	Forkhead-related transcription factor 10 (FREAC-10) (Forkhead-like 18 protein).

HB2K_HUMAN
θ value	1.06291 (rank : 1406)	NC score	0.000821 (rank : 1889)
Query Neighborhood Hits	1931	Target Neighborhood Hits	204	Shared Neighborhood Hits	35
SwissProt Accessions	P13762	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DR-W53 beta chain precursor.

HV10_MOUSE
θ value	1.06291 (rank : 1407)	NC score	-0.001332 (rank : 1930)
Query Neighborhood Hits	1931	Target Neighborhood Hits	181	Shared Neighborhood Hits	38
SwissProt Accessions	P01754, P11270	Gene names	Igh-VJ558
Domain Architecture
Description	Ig heavy chain V region 145 precursor.

HV50_MOUSE
θ value	1.06291 (rank : 1408)	NC score	-0.002704 (rank : 1949)
Query Neighborhood Hits	1931	Target Neighborhood Hits	222	Shared Neighborhood Hits	43
SwissProt Accessions	P06329	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region AC38 15.3.

KCNN1_HUMAN
θ value	1.06291 (rank : 1409)	NC score	0.002693 (rank : 1830)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q92952	Gene names	KCNN1, SK
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 1 (SK1).

LAMA5_MOUSE
θ value	1.06291 (rank : 1410)	NC score	0.012773 (rank : 1644)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	110
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LBXCO_HUMAN
θ value	1.06291 (rank : 1411)	NC score	0.008769 (rank : 1709)
Query Neighborhood Hits	1931	Target Neighborhood Hits	167	Shared Neighborhood Hits	47
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

LTBP4_MOUSE
θ value	1.06291 (rank : 1412)	NC score	0.002645 (rank : 1834)
Query Neighborhood Hits	1931	Target Neighborhood Hits	607	Shared Neighborhood Hits	96
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MINT_HUMAN
θ value	1.06291 (rank : 1413)	NC score	0.024589 (rank : 1518)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1291	Shared Neighborhood Hits	248
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MY116_MOUSE
θ value	1.06291 (rank : 1414)	NC score	0.017832 (rank : 1584)
Query Neighborhood Hits	1931	Target Neighborhood Hits	70	Shared Neighborhood Hits	18
SwissProt Accessions	P17564	Gene names	Myd116
Domain Architecture	No domain graphic available
Description	Myeloid differentiation primary response protein MyD116.

NELFA_HUMAN
θ value	1.06291 (rank : 1415)	NC score	0.019238 (rank : 1570)
Query Neighborhood Hits	1931	Target Neighborhood Hits	161	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H3P2, O95392	Gene names	WHSC2, NELFA
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein).

PDC6I_HUMAN
θ value	1.06291 (rank : 1416)	NC score	0.017607 (rank : 1586)
Query Neighborhood Hits	1931	Target Neighborhood Hits	278	Shared Neighborhood Hits	87
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

PI3R4_HUMAN
θ value	1.06291 (rank : 1417)	NC score	0.335909 (rank : 938)
Query Neighborhood Hits	1931	Target Neighborhood Hits	534	Shared Neighborhood Hits	348
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	1.06291 (rank : 1418)	NC score	0.349840 (rank : 926)
Query Neighborhood Hits	1931	Target Neighborhood Hits	535	Shared Neighborhood Hits	356
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PTPRJ_HUMAN
θ value	1.06291 (rank : 1419)	NC score	0.044997 (rank : 1375)
Query Neighborhood Hits	1931	Target Neighborhood Hits	207	Shared Neighborhood Hits	97
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTPRT_MOUSE
θ value	1.06291 (rank : 1420)	NC score	0.091699 (rank : 1189)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	123
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

PX11C_MOUSE
θ value	1.06291 (rank : 1421)	NC score	0.008577 (rank : 1716)
Query Neighborhood Hits	1931	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P6M5, Q9D8P0, Q9D8X4	Gene names	Pex11g, Pex11c
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein 11C (Peroxin-11C) (Peroxisomal biogenesis factor 11C) (PEX11gamma) (Pex11pgamma).

RBM13_MOUSE
θ value	1.06291 (rank : 1422)	NC score	0.009326 (rank : 1699)
Query Neighborhood Hits	1931	Target Neighborhood Hits	63	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BGS0, Q921E0, Q9D5G6	Gene names	Rbm13
Domain Architecture	No domain graphic available
Description	MAK16-like protein RBM13 (RNA-binding motif protein 13).

RXRB_HUMAN
θ value	1.06291 (rank : 1423)	NC score	-0.006608 (rank : 1998)
Query Neighborhood Hits	1931	Target Neighborhood Hits	280	Shared Neighborhood Hits	72
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

SF01_MOUSE
θ value	1.06291 (rank : 1424)	NC score	0.027116 (rank : 1503)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	87
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

SLAF5_MOUSE
θ value	1.06291 (rank : 1425)	NC score	0.039289 (rank : 1403)
Query Neighborhood Hits	1931	Target Neighborhood Hits	93	Shared Neighborhood Hits	57
SwissProt Accessions	Q18PI6, Q18PI7, Q3TBT1, Q3U0A2, Q8BFV0, Q9Z178	Gene names	Cd84, Slamf5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen).

SON_HUMAN
θ value	1.06291 (rank : 1426)	NC score	0.056502 (rank : 1325)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1568	Shared Neighborhood Hits	407
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

TCOF_MOUSE
θ value	1.06291 (rank : 1427)	NC score	0.032265 (rank : 1458)
Query Neighborhood Hits	1931	Target Neighborhood Hits	471	Shared Neighborhood Hits	108
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TENX_HUMAN
θ value	1.06291 (rank : 1428)	NC score	0.068763 (rank : 1262)
Query Neighborhood Hits	1931	Target Neighborhood Hits	789	Shared Neighborhood Hits	193
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TRML1_MOUSE
θ value	1.06291 (rank : 1429)	NC score	0.037262 (rank : 1418)
Query Neighborhood Hits	1931	Target Neighborhood Hits	44	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K558, Q9D3N6	Gene names	Treml1, Tlt1
Domain Architecture	No domain graphic available
Description	Trem-like transcript 1 protein precursor (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1).

VSIG4_HUMAN
θ value	1.06291 (rank : 1430)	NC score	0.263337 (rank : 994)
Query Neighborhood Hits	1931	Target Neighborhood Hits	236	Shared Neighborhood Hits	213
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

WIRE_HUMAN
θ value	1.06291 (rank : 1431)	NC score	0.032702 (rank : 1457)
Query Neighborhood Hits	1931	Target Neighborhood Hits	329	Shared Neighborhood Hits	110
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

ZN708_HUMAN
θ value	1.06291 (rank : 1432)	NC score	-0.026082 (rank : 2045)
Query Neighborhood Hits	1931	Target Neighborhood Hits	747	Shared Neighborhood Hits	48
SwissProt Accessions	P17019, Q6ZMR0	Gene names	ZNF708, KOX8, ZNF15, ZNF15L1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 708 (Zinc finger protein 15-like 1) (Zinc finger protein KOX8).

ZNF43_HUMAN
θ value	1.06291 (rank : 1433)	NC score	-0.025915 (rank : 2041)
Query Neighborhood Hits	1931	Target Neighborhood Hits	779	Shared Neighborhood Hits	51
SwissProt Accessions	P17038, P28160, Q96DG1	Gene names	ZNF43, KOX27, ZNF39
Domain Architecture
Description	Zinc finger protein 43 (Zinc protein HTF6) (Zinc finger protein KOX27).

2B1A_HUMAN
θ value	1.38821 (rank : 1434)	NC score	0.003327 (rank : 1813)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	42
SwissProt Accessions	Q30167, Q9MYF5	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-10 beta chain precursor (MHC class I antigen DRB1*10) (DRw10).

AMELX_HUMAN
θ value	1.38821 (rank : 1435)	NC score	0.016755 (rank : 1598)
Query Neighborhood Hits	1931	Target Neighborhood Hits	95	Shared Neighborhood Hits	35
SwissProt Accessions	Q99217, Q96NW6, Q9UCA7	Gene names	AMELX, AMG, AMGX
Domain Architecture
Description	Amelogenin, X isoform precursor.

CD3E_MOUSE
θ value	1.38821 (rank : 1436)	NC score	0.041817 (rank : 1387)
Query Neighborhood Hits	1931	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	P22646	Gene names	Cd3e
Domain Architecture
Description	T-cell surface glycoprotein CD3 epsilon chain precursor (T-cell surface antigen T3/Leu-4 epsilon chain).

CDS2_HUMAN
θ value	1.38821 (rank : 1437)	NC score	0.003247 (rank : 1816)
Query Neighborhood Hits	1931	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	O95674, Q5TDY2, Q5TDY3, Q5TDY4, Q5TDY5, Q9BYK5, Q9NTT2	Gene names	CDS2
Domain Architecture
Description	Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-diglyceride synthetase 2) (CDP-diglyceride pyrophosphorylase 2) (CDP- diacylglycerol synthase 2) (CDS 2) (CTP:phosphatidate cytidylyltransferase 2) (CDP-DAG synthase 2) (CDP-DG synthetase 2).

CEBPA_HUMAN
θ value	1.38821 (rank : 1438)	NC score	0.003084 (rank : 1819)
Query Neighborhood Hits	1931	Target Neighborhood Hits	99	Shared Neighborhood Hits	14
SwissProt Accessions	P49715, P78319	Gene names	CEBPA
Domain Architecture
Description	CCAAT/enhancer-binding protein alpha (C/EBP alpha).

CHD9_HUMAN
θ value	1.38821 (rank : 1439)	NC score	0.001827 (rank : 1858)
Query Neighborhood Hits	1931	Target Neighborhood Hits	343	Shared Neighborhood Hits	49
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

CIC_MOUSE
θ value	1.38821 (rank : 1440)	NC score	0.023502 (rank : 1526)
Query Neighborhood Hits	1931	Target Neighborhood Hits	742	Shared Neighborhood Hits	223
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CO1A1_MOUSE
θ value	1.38821 (rank : 1441)	NC score	0.014984 (rank : 1615)
Query Neighborhood Hits	1931	Target Neighborhood Hits	457	Shared Neighborhood Hits	146
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

COBA2_HUMAN
θ value	1.38821 (rank : 1442)	NC score	0.008723 (rank : 1710)
Query Neighborhood Hits	1931	Target Neighborhood Hits	408	Shared Neighborhood Hits	131
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

CSF1_HUMAN
θ value	1.38821 (rank : 1443)	NC score	0.024520 (rank : 1519)
Query Neighborhood Hits	1931	Target Neighborhood Hits	258	Shared Neighborhood Hits	115
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

CSTFT_HUMAN
θ value	1.38821 (rank : 1444)	NC score	-0.003224 (rank : 1955)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H0L4, O75174, Q53HK6, Q7LGE8, Q8N6T1	Gene names	CSTF2T, KIAA0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

DDX51_HUMAN
θ value	1.38821 (rank : 1445)	NC score	-0.001573 (rank : 1936)
Query Neighborhood Hits	1931	Target Neighborhood Hits	332	Shared Neighborhood Hits	81
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

DEN2A_HUMAN
θ value	1.38821 (rank : 1446)	NC score	0.001383 (rank : 1871)
Query Neighborhood Hits	1931	Target Neighborhood Hits	83	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

EGR4_HUMAN
θ value	1.38821 (rank : 1447)	NC score	-0.024417 (rank : 2032)
Query Neighborhood Hits	1931	Target Neighborhood Hits	939	Shared Neighborhood Hits	151
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

ELL_MOUSE
θ value	1.38821 (rank : 1448)	NC score	0.006113 (rank : 1769)
Query Neighborhood Hits	1931	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	O08856	Gene names	Ell
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

EMID1_MOUSE
θ value	1.38821 (rank : 1449)	NC score	0.008108 (rank : 1721)
Query Neighborhood Hits	1931	Target Neighborhood Hits	230	Shared Neighborhood Hits	86
SwissProt Accessions	Q91VF5	Gene names	Emid1, Emu1
Domain Architecture	No domain graphic available
Description	EMI domain-containing protein 1 precursor (Protein Emu1) (Emilin and multimerin domain-containing protein 1).

FPRP_HUMAN
θ value	1.38821 (rank : 1450)	NC score	0.093117 (rank : 1183)
Query Neighborhood Hits	1931	Target Neighborhood Hits	130	Shared Neighborhood Hits	111
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

GON4L_MOUSE
θ value	1.38821 (rank : 1451)	NC score	0.012537 (rank : 1651)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	108
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

HB2C_HUMAN
θ value	1.38821 (rank : 1452)	NC score	0.002732 (rank : 1828)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	41
SwissProt Accessions	P01914	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DR-1 beta chain precursor (Clone P2-beta-4).

I18RA_MOUSE
θ value	1.38821 (rank : 1453)	NC score	0.064061 (rank : 1283)
Query Neighborhood Hits	1931	Target Neighborhood Hits	93	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

IFI3_MOUSE
θ value	1.38821 (rank : 1454)	NC score	0.002175 (rank : 1848)
Query Neighborhood Hits	1931	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O35368	Gene names	Ifi203
Domain Architecture
Description	Interferon-activable protein 203 (Ifi-203) (Interferon-inducible protein p203).

IRX6_MOUSE
θ value	1.38821 (rank : 1455)	NC score	-0.005593 (rank : 1993)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ER75	Gene names	Irx6, Irxb3
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-6 (Iroquois homeobox protein 6) (Homeodomain protein IRXB3).

ITSN2_MOUSE
θ value	1.38821 (rank : 1456)	NC score	0.078877 (rank : 1228)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1371	Shared Neighborhood Hits	203
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

K1H5_HUMAN
θ value	1.38821 (rank : 1457)	NC score	-0.005673 (rank : 1994)
Query Neighborhood Hits	1931	Target Neighborhood Hits	362	Shared Neighborhood Hits	34
SwissProt Accessions	Q92764, O76012, Q92651	Gene names	KRTHA5, HHA5, HKA5
Domain Architecture
Description	Keratin, type I cuticular Ha5 (Hair keratin, type I Ha5).

LV4C_HUMAN
θ value	1.38821 (rank : 1458)	NC score	0.008346 (rank : 1717)
Query Neighborhood Hits	1931	Target Neighborhood Hits	284	Shared Neighborhood Hits	87
SwissProt Accessions	P01717	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-IV region Hil.

NEUM_MOUSE
θ value	1.38821 (rank : 1459)	NC score	0.019073 (rank : 1572)
Query Neighborhood Hits	1931	Target Neighborhood Hits	149	Shared Neighborhood Hits	37
SwissProt Accessions	P06837	Gene names	Gap43, Basp2
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Calmodulin-binding protein P-57).

NFAC3_MOUSE
θ value	1.38821 (rank : 1460)	NC score	0.006381 (rank : 1762)
Query Neighborhood Hits	1931	Target Neighborhood Hits	106	Shared Neighborhood Hits	29
SwissProt Accessions	P97305, Q60896	Gene names	Nfatc3, Nfat4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

PELP1_HUMAN
θ value	1.38821 (rank : 1461)	NC score	0.020298 (rank : 1552)
Query Neighborhood Hits	1931	Target Neighborhood Hits	596	Shared Neighborhood Hits	113
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

RBM12_HUMAN
θ value	1.38821 (rank : 1462)	NC score	0.012243 (rank : 1655)
Query Neighborhood Hits	1931	Target Neighborhood Hits	298	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NTZ6, O94865, Q8N3B1, Q9H196	Gene names	RBM12, KIAA0765
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

RERE_MOUSE
θ value	1.38821 (rank : 1463)	NC score	0.028543 (rank : 1491)
Query Neighborhood Hits	1931	Target Neighborhood Hits	785	Shared Neighborhood Hits	204
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

SF01_HUMAN
θ value	1.38821 (rank : 1464)	NC score	0.030849 (rank : 1468)
Query Neighborhood Hits	1931	Target Neighborhood Hits	287	Shared Neighborhood Hits	106
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SF3A2_MOUSE
θ value	1.38821 (rank : 1465)	NC score	0.021820 (rank : 1539)
Query Neighborhood Hits	1931	Target Neighborhood Hits	247	Shared Neighborhood Hits	96
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SIGL6_HUMAN
θ value	1.38821 (rank : 1466)	NC score	0.186087 (rank : 1045)
Query Neighborhood Hits	1931	Target Neighborhood Hits	233	Shared Neighborhood Hits	210
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

SIRPG_HUMAN
θ value	1.38821 (rank : 1467)	NC score	0.063985 (rank : 1284)
Query Neighborhood Hits	1931	Target Neighborhood Hits	359	Shared Neighborhood Hits	119
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

SLAF6_HUMAN
θ value	1.38821 (rank : 1468)	NC score	0.026856 (rank : 1505)
Query Neighborhood Hits	1931	Target Neighborhood Hits	62	Shared Neighborhood Hits	43
SwissProt Accessions	Q96DU3, Q5TAT3, Q96DV0	Gene names	SLAMF6, KALI
Domain Architecture	No domain graphic available
Description	SLAM family member 6 precursor (NK-T-B-antigen) (NTB-A) (Activating NK receptor).

SMBP2_MOUSE
θ value	1.38821 (rank : 1469)	NC score	0.004024 (rank : 1801)
Query Neighborhood Hits	1931	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

SRCA_HUMAN
θ value	1.38821 (rank : 1470)	NC score	0.007815 (rank : 1730)
Query Neighborhood Hits	1931	Target Neighborhood Hits	380	Shared Neighborhood Hits	75
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

STAM1_HUMAN
θ value	1.38821 (rank : 1471)	NC score	0.042619 (rank : 1382)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	78
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

T22D4_MOUSE
θ value	1.38821 (rank : 1472)	NC score	0.011509 (rank : 1669)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EQN3	Gene names	Tsc22d4, Tilz2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2).

TBCD3_HUMAN
θ value	1.38821 (rank : 1473)	NC score	0.002051 (rank : 1850)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZP1, Q9H0B9, Q9UDD4	Gene names	TBC1D3, PRC17
Domain Architecture
Description	TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein).

TVC_HUMAN
θ value	1.38821 (rank : 1474)	NC score	0.004629 (rank : 1792)
Query Neighborhood Hits	1931	Target Neighborhood Hits	179	Shared Neighborhood Hits	48
SwissProt Accessions	P03979	Gene names	TCRB
Domain Architecture
Description	T-cell receptor gamma chain V region PT-gamma-1/2 precursor.

WIRE_MOUSE
θ value	1.38821 (rank : 1475)	NC score	0.029119 (rank : 1487)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	111
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

ZN358_HUMAN
θ value	1.38821 (rank : 1476)	NC score	-0.025433 (rank : 2036)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

ZN619_HUMAN
θ value	1.38821 (rank : 1477)	NC score	-0.026453 (rank : 2049)
Query Neighborhood Hits	1931	Target Neighborhood Hits	749	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N2I2	Gene names	ZNF619
Domain Architecture	No domain graphic available
Description	Zinc finger protein 619.

2B14_HUMAN
θ value	1.81305 (rank : 1478)	NC score	0.000989 (rank : 1882)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	41
SwissProt Accessions	P13760, O19717, O19739, P13759, Q29875, Q30145, Q9GIX9, Q9GIY4, Q9MY13, Q9XRY5	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-4 beta chain precursor (MHC class I antigen DRB1*4) (DR-4) (DR4).

AFF1_HUMAN
θ value	1.81305 (rank : 1479)	NC score	0.019235 (rank : 1571)
Query Neighborhood Hits	1931	Target Neighborhood Hits	506	Shared Neighborhood Hits	115
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

ARHGF_HUMAN
θ value	1.81305 (rank : 1480)	NC score	0.060684 (rank : 1301)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	111
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ASPM_HUMAN
θ value	1.81305 (rank : 1481)	NC score	0.010352 (rank : 1683)
Query Neighborhood Hits	1931	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IZT6, Q86UX4, Q8IUL2, Q8IZJ7, Q8IZJ8, Q8IZJ9, Q8N4D1, Q9NVS1, Q9NVT6	Gene names	ASPM, MCPH5
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog).

BAT3_HUMAN
θ value	1.81305 (rank : 1482)	NC score	0.022162 (rank : 1536)
Query Neighborhood Hits	1931	Target Neighborhood Hits	490	Shared Neighborhood Hits	180
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BAZ2A_HUMAN
θ value	1.81305 (rank : 1483)	NC score	0.017941 (rank : 1583)
Query Neighborhood Hits	1931	Target Neighborhood Hits	780	Shared Neighborhood Hits	199
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

BMR1A_MOUSE
θ value	1.81305 (rank : 1484)	NC score	0.593065 (rank : 778)
Query Neighborhood Hits	1931	Target Neighborhood Hits	758	Shared Neighborhood Hits	749
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

CB024_MOUSE
θ value	1.81305 (rank : 1485)	NC score	0.006323 (rank : 1763)
Query Neighborhood Hits	1931	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K158, Q3TE87	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf24 homolog.

CD80_MOUSE
θ value	1.81305 (rank : 1486)	NC score	0.107259 (rank : 1146)
Query Neighborhood Hits	1931	Target Neighborhood Hits	136	Shared Neighborhood Hits	114
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

CLIC6_MOUSE
θ value	1.81305 (rank : 1487)	NC score	0.004763 (rank : 1787)
Query Neighborhood Hits	1931	Target Neighborhood Hits	134	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BHB9	Gene names	Clic6
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

CO5A2_HUMAN
θ value	1.81305 (rank : 1488)	NC score	0.012577 (rank : 1648)
Query Neighborhood Hits	1931	Target Neighborhood Hits	760	Shared Neighborhood Hits	211
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

CTTB2_HUMAN
θ value	1.81305 (rank : 1489)	NC score	0.010921 (rank : 1674)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1061	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

DGKK_HUMAN
θ value	1.81305 (rank : 1490)	NC score	0.038456 (rank : 1406)
Query Neighborhood Hits	1931	Target Neighborhood Hits	378	Shared Neighborhood Hits	126
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DTNA_MOUSE
θ value	1.81305 (rank : 1491)	NC score	0.006260 (rank : 1766)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	35
SwissProt Accessions	Q9D2N4, P97319, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0	Gene names	Dtna, Dtn
Domain Architecture
Description	Dystrobrevin alpha (Alpha-dystrobrevin).

ENAM_MOUSE
θ value	1.81305 (rank : 1492)	NC score	0.012628 (rank : 1646)
Query Neighborhood Hits	1931	Target Neighborhood Hits	229	Shared Neighborhood Hits	73
SwissProt Accessions	O55196	Gene names	Enam
Domain Architecture	No domain graphic available
Description	Enamelin precursor.

FBX42_HUMAN
θ value	1.81305 (rank : 1493)	NC score	0.004691 (rank : 1789)
Query Neighborhood Hits	1931	Target Neighborhood Hits	121	Shared Neighborhood Hits	25
SwissProt Accessions	Q6P3S6, Q5TEU8, Q86XI0, Q8N3N4, Q8N5F8, Q9BRM0, Q9P2L4	Gene names	FBXO42, FBX42, KIAA1332
Domain Architecture	No domain graphic available
Description	F-box only protein 42.

FMNL_HUMAN
θ value	1.81305 (rank : 1494)	NC score	0.019486 (rank : 1563)
Query Neighborhood Hits	1931	Target Neighborhood Hits	529	Shared Neighborhood Hits	131
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

FPRP_MOUSE
θ value	1.81305 (rank : 1495)	NC score	0.082676 (rank : 1216)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	90
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

JIP2_MOUSE
θ value	1.81305 (rank : 1496)	NC score	0.012596 (rank : 1647)
Query Neighborhood Hits	1931	Target Neighborhood Hits	144	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

K2002_HUMAN
θ value	1.81305 (rank : 1497)	NC score	0.318941 (rank : 960)
Query Neighborhood Hits	1931	Target Neighborhood Hits	274	Shared Neighborhood Hits	264
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KV4A_MOUSE
θ value	1.81305 (rank : 1498)	NC score	-0.005122 (rank : 1987)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	71
SwissProt Accessions	P01680	Gene names
Domain Architecture
Description	Ig kappa chain V-IV region S107B precursor.

LV2G_HUMAN
θ value	1.81305 (rank : 1499)	NC score	-0.004746 (rank : 1981)
Query Neighborhood Hits	1931	Target Neighborhood Hits	263	Shared Neighborhood Hits	53
SwissProt Accessions	P01710	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region BO.

LV2H_HUMAN
θ value	1.81305 (rank : 1500)	NC score	-0.003284 (rank : 1957)
Query Neighborhood Hits	1931	Target Neighborhood Hits	257	Shared Neighborhood Hits	55
SwissProt Accessions	P01711	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region VIL.

LV2K_HUMAN
θ value	1.81305 (rank : 1501)	NC score	-0.003737 (rank : 1962)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	61
SwissProt Accessions	P04209	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region NIG-84.

MLL3_HUMAN
θ value	1.81305 (rank : 1502)	NC score	0.031555 (rank : 1462)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1644	Shared Neighborhood Hits	363
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NCOR2_MOUSE
θ value	1.81305 (rank : 1503)	NC score	0.029383 (rank : 1484)
Query Neighborhood Hits	1931	Target Neighborhood Hits	790	Shared Neighborhood Hits	175
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NUDC3_HUMAN
θ value	1.81305 (rank : 1504)	NC score	0.005990 (rank : 1771)
Query Neighborhood Hits	1931	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVD9, Q9BTI3, Q9H7W9, Q9UPT4	Gene names	NUDCD3, KIAA1068
Domain Architecture	No domain graphic available
Description	NudC domain-containing protein 3.

NUMB_MOUSE
θ value	1.81305 (rank : 1505)	NC score	0.007769 (rank : 1731)
Query Neighborhood Hits	1931	Target Neighborhood Hits	91	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

PRB3_HUMAN
θ value	1.81305 (rank : 1506)	NC score	0.037705 (rank : 1413)
Query Neighborhood Hits	1931	Target Neighborhood Hits	318	Shared Neighborhood Hits	117
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

PS1C2_MOUSE
θ value	1.81305 (rank : 1507)	NC score	0.031018 (rank : 1465)
Query Neighborhood Hits	1931	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

PTPRM_HUMAN
θ value	1.81305 (rank : 1508)	NC score	0.108488 (rank : 1141)
Query Neighborhood Hits	1931	Target Neighborhood Hits	244	Shared Neighborhood Hits	147
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PVRL1_MOUSE
θ value	1.81305 (rank : 1509)	NC score	0.152922 (rank : 1076)
Query Neighborhood Hits	1931	Target Neighborhood Hits	201	Shared Neighborhood Hits	164
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

PVRL3_HUMAN
θ value	1.81305 (rank : 1510)	NC score	0.166292 (rank : 1056)
Query Neighborhood Hits	1931	Target Neighborhood Hits	204	Shared Neighborhood Hits	166
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

SHAN1_HUMAN
θ value	1.81305 (rank : 1511)	NC score	0.038165 (rank : 1409)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1041	Shared Neighborhood Hits	252
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SPAG8_HUMAN
θ value	1.81305 (rank : 1512)	NC score	0.013367 (rank : 1635)
Query Neighborhood Hits	1931	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	Q99932, Q12937, Q5TCV8, Q8WWB4	Gene names	SPAG8
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 8 (Sperm membrane protein 1) (SMP-1) (HSD-1) (Sperm membrane protein BS-84).

STABP_MOUSE
θ value	1.81305 (rank : 1513)	NC score	0.007976 (rank : 1726)
Query Neighborhood Hits	1931	Target Neighborhood Hits	191	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CQ26, Q3UTI9	Gene names	Stambp, Amsh
Domain Architecture	No domain graphic available
Description	STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3 domain of STAM).

SYN3_HUMAN
θ value	1.81305 (rank : 1514)	NC score	0.022161 (rank : 1537)
Query Neighborhood Hits	1931	Target Neighborhood Hits	203	Shared Neighborhood Hits	74
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

TM108_HUMAN
θ value	1.81305 (rank : 1515)	NC score	0.024111 (rank : 1522)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3	Gene names	TMEM108, KIAA1690
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

UB7I1_MOUSE
θ value	1.81305 (rank : 1516)	NC score	0.009094 (rank : 1703)
Query Neighborhood Hits	1931	Target Neighborhood Hits	206	Shared Neighborhood Hits	67
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

VAV2_HUMAN
θ value	1.81305 (rank : 1517)	NC score	0.130430 (rank : 1108)
Query Neighborhood Hits	1931	Target Neighborhood Hits	453	Shared Neighborhood Hits	148
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

YLPM1_HUMAN
θ value	1.81305 (rank : 1518)	NC score	0.031990 (rank : 1460)
Query Neighborhood Hits	1931	Target Neighborhood Hits	670	Shared Neighborhood Hits	171
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZN479_HUMAN
θ value	1.81305 (rank : 1519)	NC score	-0.026131 (rank : 2046)
Query Neighborhood Hits	1931	Target Neighborhood Hits	746	Shared Neighborhood Hits	53
SwissProt Accessions	Q96JC4	Gene names	ZNF479
Domain Architecture
Description	Zinc finger protein 479 (Zinc finger protein Kr19) (HKr19).

ZN516_MOUSE
θ value	1.81305 (rank : 1520)	NC score	-0.017111 (rank : 2024)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1197	Shared Neighborhood Hits	230
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ACV1C_MOUSE
θ value	2.36792 (rank : 1521)	NC score	0.526700 (rank : 807)
Query Neighborhood Hits	1931	Target Neighborhood Hits	715	Shared Neighborhood Hits	703
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

APBB1_MOUSE
θ value	2.36792 (rank : 1522)	NC score	0.000920 (rank : 1884)
Query Neighborhood Hits	1931	Target Neighborhood Hits	75	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

ARHG5_HUMAN
θ value	2.36792 (rank : 1523)	NC score	0.062937 (rank : 1291)
Query Neighborhood Hits	1931	Target Neighborhood Hits	172	Shared Neighborhood Hits	68
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARMX2_HUMAN
θ value	2.36792 (rank : 1524)	NC score	0.012144 (rank : 1656)
Query Neighborhood Hits	1931	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

BMPR2_HUMAN
θ value	2.36792 (rank : 1525)	NC score	0.570058 (rank : 797)
Query Neighborhood Hits	1931	Target Neighborhood Hits	736	Shared Neighborhood Hits	710
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	2.36792 (rank : 1526)	NC score	0.568756 (rank : 798)
Query Neighborhood Hits	1931	Target Neighborhood Hits	738	Shared Neighborhood Hits	710
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BUB1_MOUSE
θ value	2.36792 (rank : 1527)	NC score	0.548293 (rank : 801)
Query Neighborhood Hits	1931	Target Neighborhood Hits	583	Shared Neighborhood Hits	535
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CBX2_HUMAN
θ value	2.36792 (rank : 1528)	NC score	0.011981 (rank : 1659)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	93
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

CK042_HUMAN
θ value	2.36792 (rank : 1529)	NC score	0.010935 (rank : 1673)
Query Neighborhood Hits	1931	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N5U0	Gene names	C11orf42
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf42.

CMTA2_HUMAN
θ value	2.36792 (rank : 1530)	NC score	0.009697 (rank : 1692)
Query Neighborhood Hits	1931	Target Neighborhood Hits	199	Shared Neighborhood Hits	49
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CMTA2_MOUSE
θ value	2.36792 (rank : 1531)	NC score	0.012300 (rank : 1654)
Query Neighborhood Hits	1931	Target Neighborhood Hits	216	Shared Neighborhood Hits	51
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CO4A1_MOUSE
θ value	2.36792 (rank : 1532)	NC score	0.009401 (rank : 1698)
Query Neighborhood Hits	1931	Target Neighborhood Hits	450	Shared Neighborhood Hits	157
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

CO4A4_HUMAN
θ value	2.36792 (rank : 1533)	NC score	0.013381 (rank : 1634)
Query Neighborhood Hits	1931	Target Neighborhood Hits	440	Shared Neighborhood Hits	156
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

CO4A6_HUMAN
θ value	2.36792 (rank : 1534)	NC score	0.007316 (rank : 1742)
Query Neighborhood Hits	1931	Target Neighborhood Hits	318	Shared Neighborhood Hits	105
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

COCA1_MOUSE
θ value	2.36792 (rank : 1535)	NC score	0.122472 (rank : 1120)
Query Neighborhood Hits	1931	Target Neighborhood Hits	467	Shared Neighborhood Hits	225
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COIA1_MOUSE
θ value	2.36792 (rank : 1536)	NC score	0.010810 (rank : 1676)
Query Neighborhood Hits	1931	Target Neighborhood Hits	481	Shared Neighborhood Hits	143
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

COJA1_HUMAN
θ value	2.36792 (rank : 1537)	NC score	0.005810 (rank : 1772)
Query Neighborhood Hits	1931	Target Neighborhood Hits	323	Shared Neighborhood Hits	105
SwissProt Accessions	Q14993, Q00559, Q05850, Q12885, Q13676, Q5JUF0, Q5T424, Q9H572, Q9NPZ2, Q9NQP2	Gene names	COL19A1
Domain Architecture
Description	Collagen alpha-1(XIX) chain precursor (Collagen alpha-1(Y) chain).

COKA1_HUMAN
θ value	2.36792 (rank : 1538)	NC score	0.076249 (rank : 1236)
Query Neighborhood Hits	1931	Target Neighborhood Hits	403	Shared Neighborhood Hits	181
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

CTND2_MOUSE
θ value	2.36792 (rank : 1539)	NC score	0.006483 (rank : 1760)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

DNMBP_HUMAN
θ value	2.36792 (rank : 1540)	NC score	0.088773 (rank : 1195)
Query Neighborhood Hits	1931	Target Neighborhood Hits	413	Shared Neighborhood Hits	122
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

E2F2_HUMAN
θ value	2.36792 (rank : 1541)	NC score	0.002050 (rank : 1851)
Query Neighborhood Hits	1931	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	Q14209	Gene names	E2F2
Domain Architecture
Description	Transcription factor E2F2 (E2F-2).

FHOD1_MOUSE
θ value	2.36792 (rank : 1542)	NC score	0.007993 (rank : 1723)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	70
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

FOG1_MOUSE
θ value	2.36792 (rank : 1543)	NC score	-0.012303 (rank : 2012)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1237	Shared Neighborhood Hits	233
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

FOXJ1_MOUSE
θ value	2.36792 (rank : 1544)	NC score	-0.005253 (rank : 1990)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	57
SwissProt Accessions	Q61660	Gene names	Foxj1, Fkhl13, Hfh4
Domain Architecture
Description	Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4).

G3BP2_HUMAN
θ value	2.36792 (rank : 1545)	NC score	-0.000329 (rank : 1909)
Query Neighborhood Hits	1931	Target Neighborhood Hits	260	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

GAK8_HUMAN
θ value	2.36792 (rank : 1546)	NC score	-0.001292 (rank : 1929)
Query Neighborhood Hits	1931	Target Neighborhood Hits	145	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HDB9	Gene names	ERVK5
Domain Architecture	No domain graphic available
Description	HERV-K_3q12.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(II) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GSCR1_HUMAN
θ value	2.36792 (rank : 1547)	NC score	0.040012 (rank : 1394)
Query Neighborhood Hits	1931	Target Neighborhood Hits	674	Shared Neighborhood Hits	200
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HCN2_HUMAN
θ value	2.36792 (rank : 1548)	NC score	0.015918 (rank : 1605)
Query Neighborhood Hits	1931	Target Neighborhood Hits	369	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

ITA2B_HUMAN
θ value	2.36792 (rank : 1549)	NC score	-0.004209 (rank : 1970)
Query Neighborhood Hits	1931	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	P08514, O95366, Q14443	Gene names	ITGA2B, GP2B, ITGAB
Domain Architecture
Description	Integrin alpha-IIb precursor (Platelet membrane glycoprotein IIb) (GPalpha IIb) (GPIIb) (CD41 antigen) [Contains: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain].

KI3L2_HUMAN
θ value	2.36792 (rank : 1550)	NC score	0.004135 (rank : 1799)
Query Neighborhood Hits	1931	Target Neighborhood Hits	58	Shared Neighborhood Hits	23
SwissProt Accessions	P43630, Q13238, Q14947, Q14948, Q92684, Q95367	Gene names	KIR3DL2, CD158K, NKAT4
Domain Architecture	No domain graphic available
Description	Killer cell immunoglobulin-like receptor 3DL2 precursor (MHC class I NK cell receptor) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor clone CL-5) (CD158k antigen).

LAMA5_HUMAN
θ value	2.36792 (rank : 1551)	NC score	0.013395 (rank : 1633)
Query Neighborhood Hits	1931	Target Neighborhood Hits	976	Shared Neighborhood Hits	157
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LV1E_HUMAN
θ value	2.36792 (rank : 1552)	NC score	-0.001999 (rank : 1943)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	59
SwissProt Accessions	P01703	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region NEWM.

LV1G_HUMAN
θ value	2.36792 (rank : 1553)	NC score	-0.004317 (rank : 1974)
Query Neighborhood Hits	1931	Target Neighborhood Hits	266	Shared Neighborhood Hits	56
SwissProt Accessions	P06316	Gene names
Domain Architecture
Description	Ig lambda chain V-I region BL2 precursor.

MGMT_MOUSE
θ value	2.36792 (rank : 1554)	NC score	0.006981 (rank : 1750)
Query Neighborhood Hits	1931	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P26187, Q54A49	Gene names	Mgmt
Domain Architecture
Description	Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA- alkyltransferase).

MMP15_MOUSE
θ value	2.36792 (rank : 1555)	NC score	-0.005104 (rank : 1986)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	24
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

MSH4_HUMAN
θ value	2.36792 (rank : 1556)	NC score	0.001312 (rank : 1874)
Query Neighborhood Hits	1931	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	O15457, Q8NEB3, Q9UNP8	Gene names	MSH4
Domain Architecture
Description	MutS protein homolog 4.

MYO9B_MOUSE
θ value	2.36792 (rank : 1557)	NC score	0.024080 (rank : 1523)
Query Neighborhood Hits	1931	Target Neighborhood Hits	311	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NALP5_HUMAN
θ value	2.36792 (rank : 1558)	NC score	-0.002303 (rank : 1945)
Query Neighborhood Hits	1931	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

NELFA_MOUSE
θ value	2.36792 (rank : 1559)	NC score	0.017192 (rank : 1594)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9	Gene names	Whsc2, Nelfa, Whsc2h
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2).

NOTC2_HUMAN
θ value	2.36792 (rank : 1560)	NC score	0.004533 (rank : 1794)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1113	Shared Neighborhood Hits	186
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NRX2A_HUMAN
θ value	2.36792 (rank : 1561)	NC score	0.019321 (rank : 1567)
Query Neighborhood Hits	1931	Target Neighborhood Hits	614	Shared Neighborhood Hits	186
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	2.36792 (rank : 1562)	NC score	0.018594 (rank : 1577)
Query Neighborhood Hits	1931	Target Neighborhood Hits	481	Shared Neighborhood Hits	173
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

PTN23_MOUSE
θ value	2.36792 (rank : 1563)	NC score	0.024502 (rank : 1520)
Query Neighborhood Hits	1931	Target Neighborhood Hits	726	Shared Neighborhood Hits	170
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

PTPRN_MOUSE
θ value	2.36792 (rank : 1564)	NC score	0.019279 (rank : 1568)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	80
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

RB_MOUSE
θ value	2.36792 (rank : 1565)	NC score	0.004007 (rank : 1803)
Query Neighborhood Hits	1931	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P13405	Gene names	Rb1, Rb-1
Domain Architecture
Description	Retinoblastoma-associated protein (PP105) (RB).

S27A5_HUMAN
θ value	2.36792 (rank : 1566)	NC score	-0.001479 (rank : 1934)
Query Neighborhood Hits	1931	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2P5	Gene names	SLC27A5, ACSB, ACSVL6, FACVL3, FATP5
Domain Architecture	No domain graphic available
Description	Bile acyl-CoA synthetase (EC 6.2.1.7) (BACS) (Bile acid CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Very long-chain acyl-CoA synthetase homolog 2) (VLCSH2) (VLCS-H2) (Very long chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) (Fatty-acid- coenzyme A ligase, very long-chain 3) (Fatty acid transport protein 5) (FATP-5) (Solute carrier family 27 member 5).

SCND2_HUMAN
θ value	2.36792 (rank : 1567)	NC score	-0.005443 (rank : 1991)
Query Neighborhood Hits	1931	Target Neighborhood Hits	86	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZW5, Q9H9G1	Gene names	SCAND2
Domain Architecture
Description	SCAN domain-containing protein 2.

STAM1_MOUSE
θ value	2.36792 (rank : 1568)	NC score	0.042232 (rank : 1385)
Query Neighborhood Hits	1931	Target Neighborhood Hits	273	Shared Neighborhood Hits	77
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

T22D2_HUMAN
θ value	2.36792 (rank : 1569)	NC score	0.019530 (rank : 1560)
Query Neighborhood Hits	1931	Target Neighborhood Hits	250	Shared Neighborhood Hits	91
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TIF1G_MOUSE
θ value	2.36792 (rank : 1570)	NC score	0.000144 (rank : 1899)
Query Neighborhood Hits	1931	Target Neighborhood Hits	498	Shared Neighborhood Hits	103
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

TRML2_HUMAN
θ value	2.36792 (rank : 1571)	NC score	0.011798 (rank : 1663)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q5T2D2, Q8IWY0, Q9H8E9	Gene names	TREML2, C6orf76, TLT2
Domain Architecture	No domain graphic available
Description	Trem-like transcript 2 protein precursor (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2).

ZDH18_HUMAN
θ value	2.36792 (rank : 1572)	NC score	-0.000769 (rank : 1919)
Query Neighborhood Hits	1931	Target Neighborhood Hits	72	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NUE0, Q5JYH0, Q9H020	Gene names	ZDHHC18
Domain Architecture
Description	Palmitoyltransferase ZDHHC18 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 18) (DHHC-18).

ZDHC5_MOUSE
θ value	2.36792 (rank : 1573)	NC score	-0.000136 (rank : 1904)
Query Neighborhood Hits	1931	Target Neighborhood Hits	113	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VDZ4, Q69ZB5, Q8R2X7	Gene names	Zdhhc5, Kiaa1748
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 5) (DHHC-5).

ZDHC9_HUMAN
θ value	2.36792 (rank : 1574)	NC score	-0.000761 (rank : 1918)
Query Neighborhood Hits	1931	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y397, Q59EK4, Q5JSW5, Q8WWS7, Q9BPY4, Q9NSP0, Q9NVL0, Q9NVR6	Gene names	ZDHHC9, ZNF379
Domain Architecture
Description	Palmitoyltransferase ZDHHC9 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 9) (DHHC-9) (DHHC9) (Zinc finger protein 379).

ZN335_HUMAN
θ value	2.36792 (rank : 1575)	NC score	-0.023944 (rank : 2031)
Query Neighborhood Hits	1931	Target Neighborhood Hits	973	Shared Neighborhood Hits	136
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

AB1IP_MOUSE
θ value	3.0926 (rank : 1576)	NC score	0.009485 (rank : 1696)
Query Neighborhood Hits	1931	Target Neighborhood Hits	181	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

AXN2_MOUSE
θ value	3.0926 (rank : 1577)	NC score	0.000399 (rank : 1894)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	28
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

BAI1_HUMAN
θ value	3.0926 (rank : 1578)	NC score	0.012989 (rank : 1640)
Query Neighborhood Hits	1931	Target Neighborhood Hits	375	Shared Neighborhood Hits	90
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BCL9_HUMAN
θ value	3.0926 (rank : 1579)	NC score	0.036678 (rank : 1423)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1008	Shared Neighborhood Hits	309
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CJ012_HUMAN
θ value	3.0926 (rank : 1580)	NC score	0.029843 (rank : 1482)
Query Neighborhood Hits	1931	Target Neighborhood Hits	467	Shared Neighborhood Hits	111
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CLIC6_HUMAN
θ value	3.0926 (rank : 1581)	NC score	0.008675 (rank : 1713)
Query Neighborhood Hits	1931	Target Neighborhood Hits	289	Shared Neighborhood Hits	77
SwissProt Accessions	Q96NY7, Q8IX31	Gene names	CLIC6, CLIC1L
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

CMTA1_HUMAN
θ value	3.0926 (rank : 1582)	NC score	0.009563 (rank : 1695)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

COBA2_MOUSE
θ value	3.0926 (rank : 1583)	NC score	0.008598 (rank : 1714)
Query Neighborhood Hits	1931	Target Neighborhood Hits	501	Shared Neighborhood Hits	153
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

COIA1_HUMAN
θ value	3.0926 (rank : 1584)	NC score	0.012556 (rank : 1650)
Query Neighborhood Hits	1931	Target Neighborhood Hits	447	Shared Neighborhood Hits	155
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CS007_HUMAN
θ value	3.0926 (rank : 1585)	NC score	0.015098 (rank : 1614)
Query Neighborhood Hits	1931	Target Neighborhood Hits	401	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

CSKI2_MOUSE
θ value	3.0926 (rank : 1586)	NC score	0.029167 (rank : 1486)
Query Neighborhood Hits	1931	Target Neighborhood Hits	812	Shared Neighborhood Hits	222
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DNMBP_MOUSE
θ value	3.0926 (rank : 1587)	NC score	0.085274 (rank : 1202)
Query Neighborhood Hits	1931	Target Neighborhood Hits	435	Shared Neighborhood Hits	137
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EMIL1_HUMAN
θ value	3.0926 (rank : 1588)	NC score	0.003305 (rank : 1814)
Query Neighborhood Hits	1931	Target Neighborhood Hits	239	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y6C2, Q96G58, Q9UG76	Gene names	EMILIN1, EMI
Domain Architecture
Description	EMILIN-1 precursor (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1).

ERMAP_MOUSE
θ value	3.0926 (rank : 1589)	NC score	0.013925 (rank : 1623)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JLN5, Q3UV82, Q6P4T5, Q8CEH1	Gene names	Ermap
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor.

FARP2_HUMAN
θ value	3.0926 (rank : 1590)	NC score	0.057958 (rank : 1312)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	88
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FCG3A_HUMAN
θ value	3.0926 (rank : 1591)	NC score	0.063819 (rank : 1287)
Query Neighborhood Hits	1931	Target Neighborhood Hits	65	Shared Neighborhood Hits	61
SwissProt Accessions	P08637	Gene names	FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-A precursor (IgG Fc receptor III-2) (Fc-gamma RIII-alpha) (Fc-gamma RIIIa) (FcRIIIa) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16a antigen).

HCN2_MOUSE
θ value	3.0926 (rank : 1592)	NC score	0.012142 (rank : 1657)
Query Neighborhood Hits	1931	Target Neighborhood Hits	278	Shared Neighborhood Hits	105
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HSF1_HUMAN
θ value	3.0926 (rank : 1593)	NC score	0.008247 (rank : 1719)
Query Neighborhood Hits	1931	Target Neighborhood Hits	163	Shared Neighborhood Hits	54
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

HV02_MOUSE
θ value	3.0926 (rank : 1594)	NC score	-0.003698 (rank : 1960)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	44
SwissProt Accessions	P01746	Gene names
Domain Architecture
Description	Ig heavy chain V region 93G7 precursor.

HV03_MOUSE
θ value	3.0926 (rank : 1595)	NC score	-0.003386 (rank : 1958)
Query Neighborhood Hits	1931	Target Neighborhood Hits	203	Shared Neighborhood Hits	44
SwissProt Accessions	P01747	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region 36-65.

IGH1M_MOUSE
θ value	3.0926 (rank : 1596)	NC score	0.008865 (rank : 1708)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	49
SwissProt Accessions	P01869	Gene names
Domain Architecture	No domain graphic available
Description	Ig gamma-1 chain C region, membrane-bound form.

IGHG1_MOUSE
θ value	3.0926 (rank : 1597)	NC score	0.009050 (rank : 1704)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	49
SwissProt Accessions	P01868	Gene names
Domain Architecture
Description	Ig gamma-1 chain C region secreted form.

IGX1_HUMAN
θ value	3.0926 (rank : 1598)	NC score	0.012662 (rank : 1645)
Query Neighborhood Hits	1931	Target Neighborhood Hits	36	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TAG5	Gene names
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain protein MGC33530 precursor.

KLF13_HUMAN
θ value	3.0926 (rank : 1599)	NC score	-0.026018 (rank : 2043)
Query Neighborhood Hits	1931	Target Neighborhood Hits	739	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2Y9, Q9Y356	Gene names	KLF13, BTEB3, NSLP1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor NSLP1) (Novel Sp1-like zinc finger transcription factor 1).

KV3H_HUMAN
θ value	3.0926 (rank : 1600)	NC score	-0.002474 (rank : 1946)
Query Neighborhood Hits	1931	Target Neighborhood Hits	285	Shared Neighborhood Hits	71
SwissProt Accessions	P04207	Gene names
Domain Architecture
Description	Ig kappa chain V-III region CLL precursor (Rheumatoid factor).

KV5G_MOUSE
θ value	3.0926 (rank : 1601)	NC score	-0.006311 (rank : 1996)
Query Neighborhood Hits	1931	Target Neighborhood Hits	228	Shared Neighborhood Hits	60
SwissProt Accessions	P01639, P01640	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region MOPC 41 precursor.

LPIN3_HUMAN
θ value	3.0926 (rank : 1602)	NC score	0.003953 (rank : 1804)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

LPP_HUMAN
θ value	3.0926 (rank : 1603)	NC score	0.024222 (rank : 1521)
Query Neighborhood Hits	1931	Target Neighborhood Hits	775	Shared Neighborhood Hits	234
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

LV1F_HUMAN
θ value	3.0926 (rank : 1604)	NC score	-0.005156 (rank : 1988)
Query Neighborhood Hits	1931	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	P04208	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region WAH.

LV2A_HUMAN
θ value	3.0926 (rank : 1605)	NC score	-0.001335 (rank : 1931)
Query Neighborhood Hits	1931	Target Neighborhood Hits	269	Shared Neighborhood Hits	63
SwissProt Accessions	P01704	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region TOG.

LV3B_HUMAN
θ value	3.0926 (rank : 1606)	NC score	0.003262 (rank : 1815)
Query Neighborhood Hits	1931	Target Neighborhood Hits	232	Shared Neighborhood Hits	73
SwissProt Accessions	P80748	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-III region LOI.

NEST_HUMAN
θ value	3.0926 (rank : 1607)	NC score	0.019544 (rank : 1559)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1305	Shared Neighborhood Hits	192
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NFAC1_MOUSE
θ value	3.0926 (rank : 1608)	NC score	0.005771 (rank : 1773)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	O88942, O70345	Gene names	Nfatc1, Nfat2, Nfatc
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

OGG1_MOUSE
θ value	3.0926 (rank : 1609)	NC score	0.004720 (rank : 1788)
Query Neighborhood Hits	1931	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O08760, O08733, O08910, O08991, O35617, O35915, Q9QXE8	Gene names	Ogg1
Domain Architecture
Description	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)].

PELP1_MOUSE
θ value	3.0926 (rank : 1610)	NC score	0.030844 (rank : 1469)
Query Neighborhood Hits	1931	Target Neighborhood Hits	709	Shared Neighborhood Hits	202
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PHF8_MOUSE
θ value	3.0926 (rank : 1611)	NC score	-0.000282 (rank : 1907)
Query Neighborhood Hits	1931	Target Neighborhood Hits	96	Shared Neighborhood Hits	17
SwissProt Accessions	Q80TJ7, Q8BLX8, Q8BLY0, Q8BZ61, Q8CG26	Gene names	Phf8, Kiaa1111
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

PTPRM_MOUSE
θ value	3.0926 (rank : 1612)	NC score	0.105279 (rank : 1152)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	145
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRU_HUMAN
θ value	3.0926 (rank : 1613)	NC score	0.091113 (rank : 1192)
Query Neighborhood Hits	1931	Target Neighborhood Hits	237	Shared Neighborhood Hits	139
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PVRL2_MOUSE
θ value	3.0926 (rank : 1614)	NC score	0.136794 (rank : 1094)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	144
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

RSSA_HUMAN
θ value	3.0926 (rank : 1615)	NC score	0.007229 (rank : 1745)
Query Neighborhood Hits	1931	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P08865, P11085, P12030, Q16471, Q6IPD1	Gene names	RPSA, LAMBR, LAMR1
Domain Architecture
Description	40S ribosomal protein SA (p40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance- associated protein MGr1-Ag).

RSSA_MOUSE
θ value	3.0926 (rank : 1616)	NC score	0.007232 (rank : 1744)
Query Neighborhood Hits	1931	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P14206	Gene names	Rpsa, Lamr1, P40-8
Domain Architecture
Description	40S ribosomal protein SA (p40) (34/67 kDa laminin receptor).

VRK3_MOUSE
θ value	3.0926 (rank : 1617)	NC score	0.230986 (rank : 1013)
Query Neighborhood Hits	1931	Target Neighborhood Hits	342	Shared Neighborhood Hits	324
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

ZBT45_HUMAN
θ value	3.0926 (rank : 1618)	NC score	-0.026811 (rank : 2054)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	96
SwissProt Accessions	Q96K62	Gene names	ZBTB45, ZNF499
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499).

ZFHX2_HUMAN
θ value	3.0926 (rank : 1619)	NC score	-0.016187 (rank : 2021)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1178	Shared Neighborhood Hits	140
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

3BP1_HUMAN
θ value	4.03905 (rank : 1620)	NC score	0.011678 (rank : 1664)
Query Neighborhood Hits	1931	Target Neighborhood Hits	376	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ACV1C_HUMAN
θ value	4.03905 (rank : 1621)	NC score	0.522918 (rank : 808)
Query Neighborhood Hits	1931	Target Neighborhood Hits	709	Shared Neighborhood Hits	697
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ADDA_MOUSE
θ value	4.03905 (rank : 1622)	NC score	0.008309 (rank : 1718)
Query Neighborhood Hits	1931	Target Neighborhood Hits	198	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

ANX11_MOUSE
θ value	4.03905 (rank : 1623)	NC score	0.000897 (rank : 1886)
Query Neighborhood Hits	1931	Target Neighborhood Hits	200	Shared Neighborhood Hits	64
SwissProt Accessions	P97384	Gene names	Anxa11, Anx11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50).

ANXA7_HUMAN
θ value	4.03905 (rank : 1624)	NC score	0.001384 (rank : 1870)
Query Neighborhood Hits	1931	Target Neighborhood Hits	168	Shared Neighborhood Hits	56
SwissProt Accessions	P20073	Gene names	ANXA7, ANX7, SNX
Domain Architecture
Description	Annexin A7 (Annexin VII) (Synexin).

ASPM_MOUSE
θ value	4.03905 (rank : 1625)	NC score	0.006698 (rank : 1756)
Query Neighborhood Hits	1931	Target Neighborhood Hits	150	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CJ27, O88482, Q8BJI8, Q8BKT4	Gene names	Aspm, Calmbp1, Sha1
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein homolog (Calmodulin-binding protein 1) (Spindle and hydroxyurea checkpoint abnormal protein) (Calmodulin-binding protein Sha1).

BTNL1_MOUSE
θ value	4.03905 (rank : 1626)	NC score	0.051486 (rank : 1350)
Query Neighborhood Hits	1931	Target Neighborhood Hits	151	Shared Neighborhood Hits	105
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

CA106_MOUSE
θ value	4.03905 (rank : 1627)	NC score	0.007222 (rank : 1746)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

CBX6_MOUSE
θ value	4.03905 (rank : 1628)	NC score	-0.000352 (rank : 1911)
Query Neighborhood Hits	1931	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBY5, Q8BZH5	Gene names	Cbx6
Domain Architecture
Description	Chromobox protein homolog 6.

CD8A_HUMAN
θ value	4.03905 (rank : 1629)	NC score	0.015619 (rank : 1609)
Query Neighborhood Hits	1931	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	P01732, Q13970	Gene names	CD8A, MAL
Domain Architecture
Description	T-cell surface glycoprotein CD8 alpha chain precursor (T-lymphocyte differentiation antigen T8/Leu-2) (CD8a antigen).

CECR2_HUMAN
θ value	4.03905 (rank : 1630)	NC score	0.012991 (rank : 1639)
Query Neighborhood Hits	1931	Target Neighborhood Hits	543	Shared Neighborhood Hits	164
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CENA2_MOUSE
θ value	4.03905 (rank : 1631)	NC score	-0.003889 (rank : 1965)
Query Neighborhood Hits	1931	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CF141_HUMAN
θ value	4.03905 (rank : 1632)	NC score	0.007539 (rank : 1736)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SZD1, Q8N400, Q96NQ1	Gene names	C6orf141
Domain Architecture	No domain graphic available
Description	Protein C6orf141.

CHD1_HUMAN
θ value	4.03905 (rank : 1633)	NC score	-0.000181 (rank : 1905)
Query Neighborhood Hits	1931	Target Neighborhood Hits	337	Shared Neighborhood Hits	51
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CLCN1_MOUSE
θ value	4.03905 (rank : 1634)	NC score	0.000071 (rank : 1902)
Query Neighborhood Hits	1931	Target Neighborhood Hits	61	Shared Neighborhood Hits	17
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

CNTFR_MOUSE
θ value	4.03905 (rank : 1635)	NC score	0.033716 (rank : 1447)
Query Neighborhood Hits	1931	Target Neighborhood Hits	74	Shared Neighborhood Hits	47
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

CO039_HUMAN
θ value	4.03905 (rank : 1636)	NC score	0.025983 (rank : 1509)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CO039_MOUSE
θ value	4.03905 (rank : 1637)	NC score	0.034204 (rank : 1443)
Query Neighborhood Hits	1931	Target Neighborhood Hits	445	Shared Neighborhood Hits	171
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

CO8A2_HUMAN
θ value	4.03905 (rank : 1638)	NC score	0.007425 (rank : 1738)
Query Neighborhood Hits	1931	Target Neighborhood Hits	299	Shared Neighborhood Hits	107
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

CRTC1_HUMAN
θ value	4.03905 (rank : 1639)	NC score	0.019444 (rank : 1564)
Query Neighborhood Hits	1931	Target Neighborhood Hits	319	Shared Neighborhood Hits	121
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

CSF3R_MOUSE
θ value	4.03905 (rank : 1640)	NC score	0.069036 (rank : 1261)
Query Neighborhood Hits	1931	Target Neighborhood Hits	104	Shared Neighborhood Hits	71
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

CSPG4_HUMAN
θ value	4.03905 (rank : 1641)	NC score	0.009157 (rank : 1700)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	19
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

CTND2_HUMAN
θ value	4.03905 (rank : 1642)	NC score	0.011545 (rank : 1667)
Query Neighborhood Hits	1931	Target Neighborhood Hits	333	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

DCBD1_HUMAN
θ value	4.03905 (rank : 1643)	NC score	-0.000503 (rank : 1914)
Query Neighborhood Hits	1931	Target Neighborhood Hits	110	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N8Z6, Q5H992, Q8IYK5, Q8N7L9, Q96NH2	Gene names	DCBLD1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

DIAP2_MOUSE
θ value	4.03905 (rank : 1644)	NC score	0.007420 (rank : 1739)
Query Neighborhood Hits	1931	Target Neighborhood Hits	260	Shared Neighborhood Hits	65
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

DOCK4_HUMAN
θ value	4.03905 (rank : 1645)	NC score	0.006607 (rank : 1757)
Query Neighborhood Hits	1931	Target Neighborhood Hits	237	Shared Neighborhood Hits	89
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	4.03905 (rank : 1646)	NC score	0.005431 (rank : 1779)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	80
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

EMIL3_HUMAN
θ value	4.03905 (rank : 1647)	NC score	0.001970 (rank : 1853)
Query Neighborhood Hits	1931	Target Neighborhood Hits	249	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NT22, Q76KT4	Gene names	EMILIN3, C20orf130, EMILIN5
Domain Architecture	No domain graphic available
Description	EMILIN-3 precursor (EMILIN-5) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5).

ENAH_HUMAN
θ value	4.03905 (rank : 1648)	NC score	0.034533 (rank : 1439)
Query Neighborhood Hits	1931	Target Neighborhood Hits	784	Shared Neighborhood Hits	153
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

FA48A_HUMAN
θ value	4.03905 (rank : 1649)	NC score	0.006312 (rank : 1764)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NEM7, Q71RF3, Q9Y6A6	Gene names	FAM48A
Domain Architecture	No domain graphic available
Description	Protein FAM48A (p38-interacting protein) (p38IP).

FCERA_MOUSE
θ value	4.03905 (rank : 1650)	NC score	0.059382 (rank : 1306)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	50
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

GAB2_HUMAN
θ value	4.03905 (rank : 1651)	NC score	0.004217 (rank : 1797)
Query Neighborhood Hits	1931	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GGA1_HUMAN
θ value	4.03905 (rank : 1652)	NC score	0.008705 (rank : 1711)
Query Neighborhood Hits	1931	Target Neighborhood Hits	169	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

GGA2_HUMAN
θ value	4.03905 (rank : 1653)	NC score	0.002538 (rank : 1836)
Query Neighborhood Hits	1931	Target Neighborhood Hits	114	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

HAX1_HUMAN
θ value	4.03905 (rank : 1654)	NC score	0.010532 (rank : 1679)
Query Neighborhood Hits	1931	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	O00165, Q96AU4, Q9BS80	Gene names	HAX1, HS1BP1
Domain Architecture	No domain graphic available
Description	HS1-associating protein X-1 (HAX-1) (HS1-binding protein).

HPLN1_HUMAN
θ value	4.03905 (rank : 1655)	NC score	0.008972 (rank : 1705)
Query Neighborhood Hits	1931	Target Neighborhood Hits	67	Shared Neighborhood Hits	39
SwissProt Accessions	P10915	Gene names	HAPLN1, CRTL1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 1 precursor (Proteoglycan link protein) (Cartilage link protein) (LP).

HPLN1_MOUSE
θ value	4.03905 (rank : 1656)	NC score	0.007696 (rank : 1734)
Query Neighborhood Hits	1931	Target Neighborhood Hits	64	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QUP5, Q9D1G9, Q9Z1X7	Gene names	Hapln1, Crtl1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 1 precursor (Proteoglycan link protein) (Cartilage link protein) (LP).

HV14_MOUSE
θ value	4.03905 (rank : 1657)	NC score	-0.003069 (rank : 1954)
Query Neighborhood Hits	1931	Target Neighborhood Hits	222	Shared Neighborhood Hits	43
SwissProt Accessions	P01758	Gene names	Igh-VJ558
Domain Architecture
Description	Ig heavy chain V region 108A precursor.

HV52_MOUSE
θ value	4.03905 (rank : 1658)	NC score	-0.003248 (rank : 1956)
Query Neighborhood Hits	1931	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	P06327	Gene names
Domain Architecture
Description	Ig heavy chain V region VH558 A1/A4 precursor.

IRS2_HUMAN
θ value	4.03905 (rank : 1659)	NC score	0.020267 (rank : 1553)
Query Neighborhood Hits	1931	Target Neighborhood Hits	262	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

K2002_MOUSE
θ value	4.03905 (rank : 1660)	NC score	0.262733 (rank : 995)
Query Neighborhood Hits	1931	Target Neighborhood Hits	267	Shared Neighborhood Hits	234
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KCNH3_HUMAN
θ value	4.03905 (rank : 1661)	NC score	0.001724 (rank : 1860)
Query Neighborhood Hits	1931	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

KI2L4_HUMAN
θ value	4.03905 (rank : 1662)	NC score	0.006787 (rank : 1753)
Query Neighborhood Hits	1931	Target Neighborhood Hits	68	Shared Neighborhood Hits	29
SwissProt Accessions	Q99706, O14621, O14622, O14623, O14624, O43534, P78400, P78401, Q99559, Q99560, Q99561, Q99562, Q9UQJ7	Gene names	KIR2DL4, CD158D, KIR103AS
Domain Architecture
Description	Killer cell immunoglobulin-like receptor 2DL4 precursor (MHC class I NK cell receptor KIR103AS) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (G9P) (CD158d antigen).

LIPA3_MOUSE
θ value	4.03905 (rank : 1663)	NC score	0.008101 (rank : 1722)
Query Neighborhood Hits	1931	Target Neighborhood Hits	636	Shared Neighborhood Hits	70
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LV1B_HUMAN
θ value	4.03905 (rank : 1664)	NC score	-0.004195 (rank : 1969)
Query Neighborhood Hits	1931	Target Neighborhood Hits	237	Shared Neighborhood Hits	54
SwissProt Accessions	P01700	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region HA.

LV1D_HUMAN
θ value	4.03905 (rank : 1665)	NC score	-0.004500 (rank : 1976)
Query Neighborhood Hits	1931	Target Neighborhood Hits	258	Shared Neighborhood Hits	53
SwissProt Accessions	P01702	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region NIG-64.

LV1H_HUMAN
θ value	4.03905 (rank : 1666)	NC score	-0.004643 (rank : 1978)
Query Neighborhood Hits	1931	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	P06887	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region MEM.

MAP1A_HUMAN
θ value	4.03905 (rank : 1667)	NC score	0.033733 (rank : 1446)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1626	Shared Neighborhood Hits	300
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MTG8R_HUMAN
θ value	4.03905 (rank : 1668)	NC score	0.001906 (rank : 1855)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	O43439, Q5TGE4, Q5TGE7, Q8IWF3, Q96B06, Q96L00, Q9H436, Q9UJP8, Q9UJP9, Q9UP24	Gene names	CBFA2T2, EHT, MTGR1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (ETO homologous on chromosome 20) (p85).

NEIL1_MOUSE
θ value	4.03905 (rank : 1669)	NC score	0.003924 (rank : 1805)
Query Neighborhood Hits	1931	Target Neighborhood Hits	52	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4Q6, Q80V58, Q9CYT9	Gene names	Neil1, Nei1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1).

NFAC1_HUMAN
θ value	4.03905 (rank : 1670)	NC score	0.010217 (rank : 1687)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	100
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

PCLO_HUMAN
θ value	4.03905 (rank : 1671)	NC score	0.054974 (rank : 1332)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2046	Shared Neighborhood Hits	413
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PDL1_MOUSE
θ value	4.03905 (rank : 1672)	NC score	0.113945 (rank : 1132)
Query Neighborhood Hits	1931	Target Neighborhood Hits	168	Shared Neighborhood Hits	133
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PER1_MOUSE
θ value	4.03905 (rank : 1673)	NC score	0.009569 (rank : 1694)
Query Neighborhood Hits	1931	Target Neighborhood Hits	235	Shared Neighborhood Hits	90
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PHLPP_HUMAN
θ value	4.03905 (rank : 1674)	NC score	0.022692 (rank : 1531)
Query Neighborhood Hits	1931	Target Neighborhood Hits	604	Shared Neighborhood Hits	161
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

PTDSR_HUMAN
θ value	4.03905 (rank : 1675)	NC score	0.003015 (rank : 1821)
Query Neighborhood Hits	1931	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q6NYC1, Q86VY0, Q8IUM5, Q9Y4E2	Gene names	PTDSR, KIAA0585
Domain Architecture	No domain graphic available
Description	Protein PTDSR (Phosphatidylserine receptor).

PTN23_HUMAN
θ value	4.03905 (rank : 1676)	NC score	0.023436 (rank : 1527)
Query Neighborhood Hits	1931	Target Neighborhood Hits	646	Shared Neighborhood Hits	157
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

PVRL1_HUMAN
θ value	4.03905 (rank : 1677)	NC score	0.160958 (rank : 1067)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	171
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

RP1L1_MOUSE
θ value	4.03905 (rank : 1678)	NC score	0.033098 (rank : 1452)
Query Neighborhood Hits	1931	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

SCN5A_HUMAN
θ value	4.03905 (rank : 1679)	NC score	-0.004837 (rank : 1982)
Query Neighborhood Hits	1931	Target Neighborhood Hits	145	Shared Neighborhood Hits	22
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SEM4F_MOUSE
θ value	4.03905 (rank : 1680)	NC score	0.012894 (rank : 1642)
Query Neighborhood Hits	1931	Target Neighborhood Hits	59	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z123, Q9R1Y1	Gene names	Sema4f, Semaw
Domain Architecture
Description	Semaphorin-4F precursor (Semaphorin W) (Sema W).

SEM4G_HUMAN
θ value	4.03905 (rank : 1681)	NC score	0.022346 (rank : 1534)
Query Neighborhood Hits	1931	Target Neighborhood Hits	88	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NTN9, Q9HCF3	Gene names	SEMA4G, KIAA1619
Domain Architecture
Description	Semaphorin-4G precursor.

SMRC2_MOUSE
θ value	4.03905 (rank : 1682)	NC score	0.005106 (rank : 1782)
Query Neighborhood Hits	1931	Target Neighborhood Hits	487	Shared Neighborhood Hits	99
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SPRR3_MOUSE
θ value	4.03905 (rank : 1683)	NC score	0.010293 (rank : 1685)
Query Neighborhood Hits	1931	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	O09116	Gene names	Sprr3
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta).

SPT12_HUMAN
θ value	4.03905 (rank : 1684)	NC score	0.007901 (rank : 1728)
Query Neighborhood Hits	1931	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z6I5	Gene names	SPATA12, SRG5
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 12 (Spermatogenesis-related protein 5).

STAP2_HUMAN
θ value	4.03905 (rank : 1685)	NC score	0.009441 (rank : 1697)
Query Neighborhood Hits	1931	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UGK3, Q9NXI2	Gene names	STAP2, BKS
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

TBX21_MOUSE
θ value	4.03905 (rank : 1686)	NC score	-0.002744 (rank : 1950)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

TDIF1_HUMAN
θ value	4.03905 (rank : 1687)	NC score	0.004593 (rank : 1793)
Query Neighborhood Hits	1931	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H147, Q96DE3, Q9BQP2, Q9H148	Gene names	DNTTIP1, C20orf167, TDIF1
Domain Architecture	No domain graphic available
Description	Terminal deoxynucleotidyltransferase-interacting factor 1 (TdT- interacting factor 1) (TdIF1).

TFF2_HUMAN
θ value	4.03905 (rank : 1688)	NC score	0.002832 (rank : 1826)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q03403, Q15854	Gene names	TFF2, SML1
Domain Architecture
Description	Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP) (Spasmolysin).

TNC6B_HUMAN
θ value	4.03905 (rank : 1689)	NC score	0.008221 (rank : 1720)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

VGF_HUMAN
θ value	4.03905 (rank : 1690)	NC score	0.010623 (rank : 1678)
Query Neighborhood Hits	1931	Target Neighborhood Hits	167	Shared Neighborhood Hits	30
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

ZN206_HUMAN
θ value	4.03905 (rank : 1691)	NC score	-0.025905 (rank : 2040)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	90
SwissProt Accessions	Q96SZ4	Gene names	ZNF206, ZSCAN10
Domain Architecture	No domain graphic available
Description	Zinc finger protein 206 (Zinc finger and SCAN domain-containing protein 10).

ZN207_HUMAN
θ value	4.03905 (rank : 1692)	NC score	0.018912 (rank : 1576)
Query Neighborhood Hits	1931	Target Neighborhood Hits	326	Shared Neighborhood Hits	77
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

ZN595_HUMAN
θ value	4.03905 (rank : 1693)	NC score	-0.025660 (rank : 2038)
Query Neighborhood Hits	1931	Target Neighborhood Hits	798	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IYB9	Gene names	ZNF595
Domain Architecture	No domain graphic available
Description	Zinc finger protein 595.

ADA12_MOUSE
θ value	5.27518 (rank : 1694)	NC score	0.000113 (rank : 1901)
Query Neighborhood Hits	1931	Target Neighborhood Hits	474	Shared Neighborhood Hits	139
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA1D_HUMAN
θ value	5.27518 (rank : 1695)	NC score	-0.030837 (rank : 2059)
Query Neighborhood Hits	1931	Target Neighborhood Hits	937	Shared Neighborhood Hits	11
SwissProt Accessions	P25100, Q9NPY0	Gene names	ADRA1D, ADRA1A
Domain Architecture
Description	Alpha-1D adrenergic receptor (Alpha 1D-adrenoceptor) (Alpha 1D- adrenoreceptor) (Alpha-1A adrenergic receptor) (Alpha adrenergic receptor 1a).

AGRIN_HUMAN
θ value	5.27518 (rank : 1696)	NC score	0.019257 (rank : 1569)
Query Neighborhood Hits	1931	Target Neighborhood Hits	582	Shared Neighborhood Hits	82
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

ANK2_HUMAN
θ value	5.27518 (rank : 1697)	NC score	0.028419 (rank : 1493)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1615	Shared Neighborhood Hits	333
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ARHGB_HUMAN
θ value	5.27518 (rank : 1698)	NC score	0.057835 (rank : 1315)
Query Neighborhood Hits	1931	Target Neighborhood Hits	375	Shared Neighborhood Hits	108
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ATBF1_HUMAN
θ value	5.27518 (rank : 1699)	NC score	-0.017980 (rank : 2025)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1547	Shared Neighborhood Hits	178
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ATF6B_MOUSE
θ value	5.27518 (rank : 1700)	NC score	0.003080 (rank : 1820)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	24
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

ATP7B_HUMAN
θ value	5.27518 (rank : 1701)	NC score	-0.003723 (rank : 1961)
Query Neighborhood Hits	1931	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	P35670, Q16318, Q16319, Q4U3V3, Q59FJ9, Q5T7X7	Gene names	ATP7B, PWD, WC1, WND
Domain Architecture
Description	Copper-transporting ATPase 2 (EC 3.6.3.4) (Copper pump 2) (Wilson disease-associated protein).

BASP_HUMAN
θ value	5.27518 (rank : 1702)	NC score	0.036677 (rank : 1424)
Query Neighborhood Hits	1931	Target Neighborhood Hits	321	Shared Neighborhood Hits	78
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BCL9_MOUSE
θ value	5.27518 (rank : 1703)	NC score	0.030622 (rank : 1473)
Query Neighborhood Hits	1931	Target Neighborhood Hits	770	Shared Neighborhood Hits	267
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

CIZ1_HUMAN
θ value	5.27518 (rank : 1704)	NC score	0.013483 (rank : 1630)
Query Neighborhood Hits	1931	Target Neighborhood Hits	359	Shared Neighborhood Hits	91
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

CNGB1_HUMAN
θ value	5.27518 (rank : 1705)	NC score	0.007445 (rank : 1737)
Query Neighborhood Hits	1931	Target Neighborhood Hits	222	Shared Neighborhood Hits	42
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CO9A2_MOUSE
θ value	5.27518 (rank : 1706)	NC score	0.006100 (rank : 1770)
Query Neighborhood Hits	1931	Target Neighborhood Hits	279	Shared Neighborhood Hits	98
SwissProt Accessions	Q07643	Gene names	Col9a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

CUED1_MOUSE
θ value	5.27518 (rank : 1707)	NC score	0.002994 (rank : 1822)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3V6	Gene names	Cuedc1
Domain Architecture
Description	CUE domain-containing protein 1.

DC1L2_HUMAN
θ value	5.27518 (rank : 1708)	NC score	0.002430 (rank : 1839)
Query Neighborhood Hits	1931	Target Neighborhood Hits	39	Shared Neighborhood Hits	13
SwissProt Accessions	O43237, Q8TAT3	Gene names	DYNC1LI2, DNCLI2, LIC2
Domain Architecture
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC53/55) (LIC-2).

DC1L2_MOUSE
θ value	5.27518 (rank : 1709)	NC score	0.011518 (rank : 1668)
Query Neighborhood Hits	1931	Target Neighborhood Hits	173	Shared Neighborhood Hits	67
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

DTNA_HUMAN
θ value	5.27518 (rank : 1710)	NC score	0.005646 (rank : 1776)
Query Neighborhood Hits	1931	Target Neighborhood Hits	295	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y4J8, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500	Gene names	DTNA, DRP3
Domain Architecture
Description	Dystrobrevin alpha (Dystrobrevin-alpha) (Dystrophin-related protein 3).

EP400_HUMAN
θ value	5.27518 (rank : 1711)	NC score	0.010519 (rank : 1680)
Query Neighborhood Hits	1931	Target Neighborhood Hits	556	Shared Neighborhood Hits	152
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

GGN_MOUSE
θ value	5.27518 (rank : 1712)	NC score	0.028613 (rank : 1490)
Query Neighborhood Hits	1931	Target Neighborhood Hits	311	Shared Neighborhood Hits	107
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

GP123_HUMAN
θ value	5.27518 (rank : 1713)	NC score	0.003799 (rank : 1806)
Query Neighborhood Hits	1931	Target Neighborhood Hits	120	Shared Neighborhood Hits	33
SwissProt Accessions	Q86SQ6, Q86SN7, Q96JJ9	Gene names	GPR123, KIAA1828
Domain Architecture
Description	Probable G-protein coupled receptor 123.

HAIR_MOUSE
θ value	5.27518 (rank : 1714)	NC score	0.002376 (rank : 1842)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	27
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

HMMR_HUMAN
θ value	5.27518 (rank : 1715)	NC score	0.012102 (rank : 1658)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1082	Shared Neighborhood Hits	90
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

HV15_MOUSE
θ value	5.27518 (rank : 1716)	NC score	-0.001749 (rank : 1940)
Query Neighborhood Hits	1931	Target Neighborhood Hits	170	Shared Neighborhood Hits	45
SwissProt Accessions	P01759	Gene names
Domain Architecture
Description	Ig heavy chain V region BCL1 precursor.

HV1F_HUMAN
θ value	5.27518 (rank : 1717)	NC score	-0.004317 (rank : 1973)
Query Neighborhood Hits	1931	Target Neighborhood Hits	183	Shared Neighborhood Hits	39
SwissProt Accessions	P06326	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V-I region Mot.

ICAM1_HUMAN
θ value	5.27518 (rank : 1718)	NC score	0.085241 (rank : 1203)
Query Neighborhood Hits	1931	Target Neighborhood Hits	80	Shared Neighborhood Hits	69
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

IL4RA_MOUSE
θ value	5.27518 (rank : 1719)	NC score	0.010325 (rank : 1684)
Query Neighborhood Hits	1931	Target Neighborhood Hits	194	Shared Neighborhood Hits	82
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

JAD1D_HUMAN
θ value	5.27518 (rank : 1720)	NC score	-0.003987 (rank : 1967)
Query Neighborhood Hits	1931	Target Neighborhood Hits	147	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BY66, Q92509, Q92809, Q9HCU1	Gene names	SMCY, HY, HYA, JARID1D, KIAA0234
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

KCNH3_MOUSE
θ value	5.27518 (rank : 1721)	NC score	0.000370 (rank : 1895)
Query Neighborhood Hits	1931	Target Neighborhood Hits	133	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

LAD1_HUMAN
θ value	5.27518 (rank : 1722)	NC score	0.035866 (rank : 1431)
Query Neighborhood Hits	1931	Target Neighborhood Hits	441	Shared Neighborhood Hits	105
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

LDB3_HUMAN
θ value	5.27518 (rank : 1723)	NC score	0.004791 (rank : 1786)
Query Neighborhood Hits	1931	Target Neighborhood Hits	497	Shared Neighborhood Hits	112
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

LV2E_HUMAN
θ value	5.27518 (rank : 1724)	NC score	-0.005538 (rank : 1992)
Query Neighborhood Hits	1931	Target Neighborhood Hits	259	Shared Neighborhood Hits	54
SwissProt Accessions	P01708	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region BUR.

LV4B_HUMAN
θ value	5.27518 (rank : 1725)	NC score	-0.000708 (rank : 1917)
Query Neighborhood Hits	1931	Target Neighborhood Hits	202	Shared Neighborhood Hits	54
SwissProt Accessions	P01716	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-IV region X.

LV4D_HUMAN
θ value	5.27518 (rank : 1726)	NC score	-0.000314 (rank : 1908)
Query Neighborhood Hits	1931	Target Neighborhood Hits	199	Shared Neighborhood Hits	56
SwissProt Accessions	P01718	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-IV region Kern.

LY9_MOUSE
θ value	5.27518 (rank : 1727)	NC score	0.069130 (rank : 1260)
Query Neighborhood Hits	1931	Target Neighborhood Hits	110	Shared Neighborhood Hits	80
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

MTG8R_MOUSE
θ value	5.27518 (rank : 1728)	NC score	0.002106 (rank : 1849)
Query Neighborhood Hits	1931	Target Neighborhood Hits	124	Shared Neighborhood Hits	22
SwissProt Accessions	O70374	Gene names	Cbfa2t2, Cbfa2t2h, Mtgr1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1).

MYCB2_HUMAN
θ value	5.27518 (rank : 1729)	NC score	0.012366 (rank : 1653)
Query Neighborhood Hits	1931	Target Neighborhood Hits	390	Shared Neighborhood Hits	61
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

NCOR1_MOUSE
θ value	5.27518 (rank : 1730)	NC score	0.013557 (rank : 1629)
Query Neighborhood Hits	1931	Target Neighborhood Hits	521	Shared Neighborhood Hits	99
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

NUMBL_HUMAN
θ value	5.27518 (rank : 1731)	NC score	0.013291 (rank : 1636)
Query Neighborhood Hits	1931	Target Neighborhood Hits	394	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

PA24A_MOUSE
θ value	5.27518 (rank : 1732)	NC score	0.007387 (rank : 1740)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PHF8_HUMAN
θ value	5.27518 (rank : 1733)	NC score	0.001241 (rank : 1878)
Query Neighborhood Hits	1931	Target Neighborhood Hits	105	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UPP1, Q5H9U5, Q5VUJ4, Q7Z6D4, Q9HAH2	Gene names	PHF8, KIAA1111, ZNF422
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

PRD13_HUMAN
θ value	5.27518 (rank : 1734)	NC score	-0.026854 (rank : 2055)
Query Neighborhood Hits	1931	Target Neighborhood Hits	716	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4Q3, Q5TGC1	Gene names	PRDM13, PFM10
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 13 (PR domain-containing protein 13).

RIMB1_HUMAN
θ value	5.27518 (rank : 1735)	NC score	0.042781 (rank : 1380)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1479	Shared Neighborhood Hits	290
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RTN1_MOUSE
θ value	5.27518 (rank : 1736)	NC score	0.015495 (rank : 1610)
Query Neighborhood Hits	1931	Target Neighborhood Hits	189	Shared Neighborhood Hits	67
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SEM4B_MOUSE
θ value	5.27518 (rank : 1737)	NC score	0.013470 (rank : 1631)
Query Neighborhood Hits	1931	Target Neighborhood Hits	67	Shared Neighborhood Hits	27
SwissProt Accessions	Q62179, Q4PKI6, Q69ZB7	Gene names	Sema4b, Kiaa1745, Semac, SemC
Domain Architecture	No domain graphic available
Description	Semaphorin-4B precursor (Semaphorin C) (Sema C).

SFR14_MOUSE
θ value	5.27518 (rank : 1738)	NC score	0.002718 (rank : 1829)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

TMAP1_HUMAN
θ value	5.27518 (rank : 1739)	NC score	0.019492 (rank : 1562)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	50
SwissProt Accessions	P84157	Gene names	TMAP1
Domain Architecture	No domain graphic available
Description	Transmembrane anchor protein 1.

TMPSD_HUMAN
θ value	5.27518 (rank : 1740)	NC score	-0.011404 (rank : 2010)
Query Neighborhood Hits	1931	Target Neighborhood Hits	333	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

ZBT46_HUMAN
θ value	5.27518 (rank : 1741)	NC score	-0.029011 (rank : 2058)
Query Neighborhood Hits	1931	Target Neighborhood Hits	813	Shared Neighborhood Hits	46
SwissProt Accessions	Q86UZ6, Q5JWJ3, Q9BQK3, Q9H3Z8, Q9H3Z9	Gene names	ZBTB46, BTBD4, ZNF340
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 46 (BTB/POZ domain- containing protein 4) (Zinc finger protein 340).

ZCH11_HUMAN
θ value	5.27518 (rank : 1742)	NC score	0.007331 (rank : 1741)
Query Neighborhood Hits	1931	Target Neighborhood Hits	278	Shared Neighborhood Hits	54
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

ZIC5_HUMAN
θ value	5.27518 (rank : 1743)	NC score	-0.025261 (rank : 2034)
Query Neighborhood Hits	1931	Target Neighborhood Hits	774	Shared Neighborhood Hits	80
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

ZN414_HUMAN
θ value	5.27518 (rank : 1744)	NC score	-0.009220 (rank : 2007)
Query Neighborhood Hits	1931	Target Neighborhood Hits	548	Shared Neighborhood Hits	70
SwissProt Accessions	Q96IQ9	Gene names	ZNF414
Domain Architecture	No domain graphic available
Description	Zinc finger protein 414.

ZN438_HUMAN
θ value	5.27518 (rank : 1745)	NC score	-0.020837 (rank : 2027)
Query Neighborhood Hits	1931	Target Neighborhood Hits	906	Shared Neighborhood Hits	126
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

ZN621_HUMAN
θ value	5.27518 (rank : 1746)	NC score	-0.026725 (rank : 2052)
Query Neighborhood Hits	1931	Target Neighborhood Hits	737	Shared Neighborhood Hits	46
SwissProt Accessions	Q6ZSS3, Q8TE91	Gene names	ZNF621
Domain Architecture	No domain graphic available
Description	Zinc finger protein 621.

ZN713_HUMAN
θ value	5.27518 (rank : 1747)	NC score	-0.027334 (rank : 2056)
Query Neighborhood Hits	1931	Target Neighborhood Hits	728	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N859	Gene names	ZNF713
Domain Architecture	No domain graphic available
Description	Zinc finger protein 713.

2DMB_MOUSE
θ value	6.88961 (rank : 1748)	NC score	0.000193 (rank : 1898)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	44
SwissProt Accessions	P35737	Gene names	H2-DMb1, H-2Mb1, Mb
Domain Architecture
Description	Class II histocompatibility antigen, M beta 1 chain precursor (H2-M beta 1 chain).

ABP1_HUMAN
θ value	6.88961 (rank : 1749)	NC score	-0.000598 (rank : 1915)
Query Neighborhood Hits	1931	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P19801, Q16683, Q16684, Q56II4, Q6GU42	Gene names	ABP1, AOC1, DAO1
Domain Architecture
Description	Amiloride-sensitive amine oxidase [copper-containing] precursor (EC 1.4.3.6) (Diamine oxidase) (DAO) (Amiloride-binding protein) (ABP) (Histaminase) (Kidney amine oxidase) (KAO).

AFF3_HUMAN
θ value	6.88961 (rank : 1750)	NC score	0.007184 (rank : 1748)
Query Neighborhood Hits	1931	Target Neighborhood Hits	190	Shared Neighborhood Hits	51
SwissProt Accessions	P51826	Gene names	AFF3, LAF4
Domain Architecture
Description	AF4/FMR2 family member 3 (Protein LAF-4) (Lymphoid nuclear protein related to AF4).

ANKF1_HUMAN
θ value	6.88961 (rank : 1751)	NC score	0.066894 (rank : 1270)
Query Neighborhood Hits	1931	Target Neighborhood Hits	126	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

ARI1A_HUMAN
θ value	6.88961 (rank : 1752)	NC score	0.027054 (rank : 1504)
Query Neighborhood Hits	1931	Target Neighborhood Hits	787	Shared Neighborhood Hits	243
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

AUTS2_HUMAN
θ value	6.88961 (rank : 1753)	NC score	0.014846 (rank : 1617)
Query Neighborhood Hits	1931	Target Neighborhood Hits	342	Shared Neighborhood Hits	102
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

BAT3_MOUSE
θ value	6.88961 (rank : 1754)	NC score	0.020912 (rank : 1544)
Query Neighborhood Hits	1931	Target Neighborhood Hits	518	Shared Neighborhood Hits	187
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

BT3A1_HUMAN
θ value	6.88961 (rank : 1755)	NC score	0.029233 (rank : 1485)
Query Neighborhood Hits	1931	Target Neighborhood Hits	229	Shared Neighborhood Hits	110
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

BTBD7_HUMAN
θ value	6.88961 (rank : 1756)	NC score	-0.002682 (rank : 1948)
Query Neighborhood Hits	1931	Target Neighborhood Hits	176	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P203, Q69Z05, Q7Z308, Q86TS0, Q9HAA4, Q9NVM0	Gene names	BTBD7, KIAA1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

BTNL8_HUMAN
θ value	6.88961 (rank : 1757)	NC score	0.017584 (rank : 1587)
Query Neighborhood Hits	1931	Target Neighborhood Hits	177	Shared Neighborhood Hits	73
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

CAC1A_HUMAN
θ value	6.88961 (rank : 1758)	NC score	0.002299 (rank : 1845)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	116
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CD248_MOUSE
θ value	6.88961 (rank : 1759)	NC score	0.010374 (rank : 1682)
Query Neighborhood Hits	1931	Target Neighborhood Hits	578	Shared Neighborhood Hits	141
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CE005_MOUSE
θ value	6.88961 (rank : 1760)	NC score	-0.002139 (rank : 1944)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CENPT_HUMAN
θ value	6.88961 (rank : 1761)	NC score	0.003683 (rank : 1809)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q96BT3, Q96I29, Q96IC6, Q96NK9, Q9H901	Gene names	CENPT, C16orf56, ICEN22
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T) (Interphase centromere complex protein 22).

CLCN2_HUMAN
θ value	6.88961 (rank : 1762)	NC score	-0.001499 (rank : 1935)
Query Neighborhood Hits	1931	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	P51788, O14864, Q8WU13	Gene names	CLCN2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

COHA1_MOUSE
θ value	6.88961 (rank : 1763)	NC score	0.011459 (rank : 1670)
Query Neighborhood Hits	1931	Target Neighborhood Hits	414	Shared Neighborhood Hits	136
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CPSF6_HUMAN
θ value	6.88961 (rank : 1764)	NC score	0.015637 (rank : 1607)
Query Neighborhood Hits	1931	Target Neighborhood Hits	359	Shared Neighborhood Hits	119
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	6.88961 (rank : 1765)	NC score	0.016163 (rank : 1604)
Query Neighborhood Hits	1931	Target Neighborhood Hits	356	Shared Neighborhood Hits	122
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CROCC_HUMAN
θ value	6.88961 (rank : 1766)	NC score	0.011555 (rank : 1666)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1409	Shared Neighborhood Hits	135
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CUTL1_HUMAN
θ value	6.88961 (rank : 1767)	NC score	0.005687 (rank : 1775)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1574	Shared Neighborhood Hits	191
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

EDEM1_HUMAN
θ value	6.88961 (rank : 1768)	NC score	-0.001083 (rank : 1925)
Query Neighborhood Hits	1931	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

EMIL1_MOUSE
θ value	6.88961 (rank : 1769)	NC score	0.002190 (rank : 1847)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	56
SwissProt Accessions	Q99K41	Gene names	Emilin1
Domain Architecture
Description	EMILIN-1 precursor (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1).

EP300_HUMAN
θ value	6.88961 (rank : 1770)	NC score	0.024672 (rank : 1517)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	236
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

EPN1_MOUSE
θ value	6.88961 (rank : 1771)	NC score	0.017116 (rank : 1595)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	90
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

EVI1_HUMAN
θ value	6.88961 (rank : 1772)	NC score	-0.025755 (rank : 2039)
Query Neighborhood Hits	1931	Target Neighborhood Hits	924	Shared Neighborhood Hits	84
SwissProt Accessions	Q03112, Q16122, Q99917	Gene names	EVI1
Domain Architecture
Description	Ecotropic virus integration 1 site protein.

FCERA_HUMAN
θ value	6.88961 (rank : 1773)	NC score	0.132516 (rank : 1106)
Query Neighborhood Hits	1931	Target Neighborhood Hits	150	Shared Neighborhood Hits	132
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

FOXD2_HUMAN
θ value	6.88961 (rank : 1774)	NC score	-0.007468 (rank : 2002)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	23
SwissProt Accessions	O60548	Gene names	FOXD2, FKHL17, FREAC9
Domain Architecture
Description	Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead- related transcription factor 9) (FREAC-9).

FXL13_HUMAN
θ value	6.88961 (rank : 1775)	NC score	0.000520 (rank : 1891)
Query Neighborhood Hits	1931	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

GAK4_HUMAN
θ value	6.88961 (rank : 1776)	NC score	0.008881 (rank : 1707)
Query Neighborhood Hits	1931	Target Neighborhood Hits	415	Shared Neighborhood Hits	153
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HCFC2_HUMAN
θ value	6.88961 (rank : 1777)	NC score	0.067829 (rank : 1267)
Query Neighborhood Hits	1931	Target Neighborhood Hits	154	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

HES6_HUMAN
θ value	6.88961 (rank : 1778)	NC score	-0.001640 (rank : 1939)
Query Neighborhood Hits	1931	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HHLA2_HUMAN
θ value	6.88961 (rank : 1779)	NC score	0.104438 (rank : 1154)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

HPLN4_MOUSE
θ value	6.88961 (rank : 1780)	NC score	0.017292 (rank : 1592)
Query Neighborhood Hits	1931	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q80WM4, Q80XX2	Gene names	Hapln4, Bral2, Lpr4
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2) (Link protein 4).

HV06_MOUSE
θ value	6.88961 (rank : 1781)	NC score	-0.003053 (rank : 1953)
Query Neighborhood Hits	1931	Target Neighborhood Hits	259	Shared Neighborhood Hits	49
SwissProt Accessions	P01750	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region 102 precursor.

HXC5_HUMAN
θ value	6.88961 (rank : 1782)	NC score	-0.014289 (rank : 2016)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	23
SwissProt Accessions	Q00444	Gene names	HOXC5, HOX3D
Domain Architecture
Description	Homeobox protein Hox-C5 (Hox-3D) (CP11).

IASPP_MOUSE
θ value	6.88961 (rank : 1783)	NC score	0.051619 (rank : 1349)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1024	Shared Neighborhood Hits	315
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IGHE_HUMAN
θ value	6.88961 (rank : 1784)	NC score	0.017631 (rank : 1585)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	58
SwissProt Accessions	P01854	Gene names	IGHE
Domain Architecture
Description	Ig epsilon chain C region.

IRS2_MOUSE
θ value	6.88961 (rank : 1785)	NC score	0.017417 (rank : 1591)
Query Neighborhood Hits	1931	Target Neighborhood Hits	248	Shared Neighborhood Hits	91
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

JAD1C_HUMAN
θ value	6.88961 (rank : 1786)	NC score	-0.002769 (rank : 1951)
Query Neighborhood Hits	1931	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	P41229	Gene names	SMCX, DXS1272E, JARID1C, XE169
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1C (Protein SmcX) (Protein Xe169).

LAD1_MOUSE
θ value	6.88961 (rank : 1787)	NC score	0.039768 (rank : 1397)
Query Neighborhood Hits	1931	Target Neighborhood Hits	391	Shared Neighborhood Hits	111
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LBXCO_MOUSE
θ value	6.88961 (rank : 1788)	NC score	0.005188 (rank : 1781)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

LV5A_HUMAN
θ value	6.88961 (rank : 1789)	NC score	0.004168 (rank : 1798)
Query Neighborhood Hits	1931	Target Neighborhood Hits	220	Shared Neighborhood Hits	70
SwissProt Accessions	P01719	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-V region DEL.

MYO9B_HUMAN
θ value	6.88961 (rank : 1790)	NC score	0.029952 (rank : 1479)
Query Neighborhood Hits	1931	Target Neighborhood Hits	641	Shared Neighborhood Hits	187
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NEB2_HUMAN
θ value	6.88961 (rank : 1791)	NC score	0.007977 (rank : 1725)
Query Neighborhood Hits	1931	Target Neighborhood Hits	883	Shared Neighborhood Hits	95
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	6.88961 (rank : 1792)	NC score	0.009865 (rank : 1690)
Query Neighborhood Hits	1931	Target Neighborhood Hits	889	Shared Neighborhood Hits	102
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NECD_MOUSE
θ value	6.88961 (rank : 1793)	NC score	-0.003866 (rank : 1964)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	P25233, Q542W7, Q61951	Gene names	Ndn
Domain Architecture
Description	Necdin.

NFAC3_HUMAN
θ value	6.88961 (rank : 1794)	NC score	0.002990 (rank : 1823)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	25
SwissProt Accessions	Q12968, O75211, Q14516, Q99840, Q99841, Q99842	Gene names	NFATC3, NFAT4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

P53_HUMAN
θ value	6.88961 (rank : 1795)	NC score	0.000496 (rank : 1892)
Query Neighborhood Hits	1931	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61	Gene names	TP53, P53
Domain Architecture
Description	Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).

PA24A_HUMAN
θ value	6.88961 (rank : 1796)	NC score	0.007214 (rank : 1747)
Query Neighborhood Hits	1931	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

PARD3_HUMAN
θ value	6.88961 (rank : 1797)	NC score	-0.000863 (rank : 1922)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

PDL1_HUMAN
θ value	6.88961 (rank : 1798)	NC score	0.137645 (rank : 1093)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

RA54B_HUMAN
θ value	6.88961 (rank : 1799)	NC score	-0.001578 (rank : 1937)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y620	Gene names	RAD54B
Domain Architecture	No domain graphic available
Description	DNA repair and recombination protein RAD54B (EC 3.6.1.-) (RAD54 homolog B).

RFTN1_MOUSE
θ value	6.88961 (rank : 1800)	NC score	0.001702 (rank : 1862)
Query Neighborhood Hits	1931	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	Q6A0D4, Q3U654, Q3U8P6, Q80US1	Gene names	Rftn1, Kiaa0084
Domain Architecture	No domain graphic available
Description	Raftlin (Raft-linking protein).

SC10A_MOUSE
θ value	6.88961 (rank : 1801)	NC score	-0.005060 (rank : 1985)
Query Neighborhood Hits	1931	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SI1L1_MOUSE
θ value	6.88961 (rank : 1802)	NC score	-0.000778 (rank : 1920)
Query Neighborhood Hits	1931	Target Neighborhood Hits	189	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SIP1_MOUSE
θ value	6.88961 (rank : 1803)	NC score	-0.026548 (rank : 2050)
Query Neighborhood Hits	1931	Target Neighborhood Hits	870	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

TGFR1_HUMAN
θ value	6.88961 (rank : 1804)	NC score	0.583266 (rank : 785)
Query Neighborhood Hits	1931	Target Neighborhood Hits	755	Shared Neighborhood Hits	748
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	6.88961 (rank : 1805)	NC score	0.582948 (rank : 786)
Query Neighborhood Hits	1931	Target Neighborhood Hits	753	Shared Neighborhood Hits	748
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TM55B_MOUSE
θ value	6.88961 (rank : 1806)	NC score	0.002677 (rank : 1831)
Query Neighborhood Hits	1931	Target Neighborhood Hits	50	Shared Neighborhood Hits	20
SwissProt Accessions	Q3TWL2	Gene names	Tmem55b
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55B (EC 3.1.3.-) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase I).

TREM2_HUMAN
θ value	6.88961 (rank : 1807)	NC score	0.020322 (rank : 1551)
Query Neighborhood Hits	1931	Target Neighborhood Hits	60	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZC2, Q8N5H8, Q8WYN6	Gene names	TREM2
Domain Architecture	No domain graphic available
Description	Triggering receptor expressed on myeloid cells 2 precursor (Triggering receptor expressed on monocytes 2) (TREM-2).

TTDN1_HUMAN
θ value	6.88961 (rank : 1808)	NC score	0.015233 (rank : 1612)
Query Neighborhood Hits	1931	Target Neighborhood Hits	43	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TAP9	Gene names	TTDN1, C7orf11
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein.

UBE4B_HUMAN
θ value	6.88961 (rank : 1809)	NC score	0.005333 (rank : 1780)
Query Neighborhood Hits	1931	Target Neighborhood Hits	158	Shared Neighborhood Hits	47
SwissProt Accessions	O95155, O75169, O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7	Gene names	UBE4B, HDNB1, KIAA0684, UFD2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1).

UNC5A_HUMAN
θ value	6.88961 (rank : 1810)	NC score	0.120550 (rank : 1123)
Query Neighborhood Hits	1931	Target Neighborhood Hits	198	Shared Neighborhood Hits	127
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

UNC5A_MOUSE
θ value	6.88961 (rank : 1811)	NC score	0.106949 (rank : 1147)
Query Neighborhood Hits	1931	Target Neighborhood Hits	203	Shared Neighborhood Hits	124
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

VPP2_MOUSE
θ value	6.88961 (rank : 1812)	NC score	-0.001618 (rank : 1938)
Query Neighborhood Hits	1931	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	P15920, Q3U2X3, Q9JHJ2	Gene names	Atp6v0a2, Atp6n1b, Tj6
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (Immune suppressor factor J6B7).

WASF2_MOUSE
θ value	6.88961 (rank : 1813)	NC score	0.018481 (rank : 1579)
Query Neighborhood Hits	1931	Target Neighborhood Hits	315	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

WASL_HUMAN
θ value	6.88961 (rank : 1814)	NC score	0.037657 (rank : 1416)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	125
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

XKR6_HUMAN
θ value	6.88961 (rank : 1815)	NC score	-0.000827 (rank : 1921)
Query Neighborhood Hits	1931	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q5GH73, Q8TBA0	Gene names	XKR6, C8orf21, C8orf7, XRG6
Domain Architecture	No domain graphic available
Description	XK-related protein 6.

ZDHC8_HUMAN
θ value	6.88961 (rank : 1816)	NC score	0.001887 (rank : 1856)
Query Neighborhood Hits	1931	Target Neighborhood Hits	234	Shared Neighborhood Hits	95
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

ZN502_HUMAN
θ value	6.88961 (rank : 1817)	NC score	-0.026780 (rank : 2053)
Query Neighborhood Hits	1931	Target Neighborhood Hits	762	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TBZ5	Gene names	ZNF502
Domain Architecture	No domain graphic available
Description	Zinc finger protein 502.

ZN718_HUMAN
θ value	6.88961 (rank : 1818)	NC score	-0.025957 (rank : 2042)
Query Neighborhood Hits	1931	Target Neighborhood Hits	761	Shared Neighborhood Hits	52
SwissProt Accessions	Q3SXZ3, Q3SXZ4, Q3SXZ5	Gene names	ZNF718
Domain Architecture	No domain graphic available
Description	Zinc finger protein 718.

2DMB_HUMAN
θ value	8.99809 (rank : 1819)	NC score	0.000360 (rank : 1896)
Query Neighborhood Hits	1931	Target Neighborhood Hits	216	Shared Neighborhood Hits	46
SwissProt Accessions	P28068, O77936, Q13012, Q29751, Q9XRX2	Gene names	HLA-DMB, DMB, RING7
Domain Architecture
Description	HLA class II histocompatibility antigen, DM beta chain precursor (MHC class II antigen DMB).

ACOT8_MOUSE
θ value	8.99809 (rank : 1820)	NC score	0.001696 (rank : 1863)
Query Neighborhood Hits	1931	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P58137, Q8VHM4	Gene names	Acot8, Pte1, Pte2
Domain Architecture
Description	Acyl-coenzyme A thioesterase 8 (EC 3.1.2.2) (Acyl-CoA thioesterase 8) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-coA thioesterase 1) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2).

AF17_HUMAN
θ value	8.99809 (rank : 1821)	NC score	0.005709 (rank : 1774)
Query Neighborhood Hits	1931	Target Neighborhood Hits	230	Shared Neighborhood Hits	62
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

B3A2_MOUSE
θ value	8.99809 (rank : 1822)	NC score	-0.003041 (rank : 1952)
Query Neighborhood Hits	1931	Target Neighborhood Hits	64	Shared Neighborhood Hits	14
SwissProt Accessions	P13808, Q9ES09, Q9ES10, Q9ES11, Q9ES12, Q9ES13	Gene names	Slc4a2, Ae2
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (B3RP).

B4GN3_HUMAN
θ value	8.99809 (rank : 1823)	NC score	0.002301 (rank : 1844)
Query Neighborhood Hits	1931	Target Neighborhood Hits	128	Shared Neighborhood Hits	43
SwissProt Accessions	Q6L9W6, Q6ZNC1, Q8N7T6	Gene names	B4GALNT3
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.244) (NGalNAc-T2) (Beta- 1,4-N-acetylgalactosaminyltransferase III) (Beta4GalNAc-T3) (Beta4GalNAcT3).

BAZ1B_HUMAN
θ value	8.99809 (rank : 1824)	NC score	0.004864 (rank : 1785)
Query Neighborhood Hits	1931	Target Neighborhood Hits	701	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

BIN1_MOUSE
θ value	8.99809 (rank : 1825)	NC score	0.011959 (rank : 1660)
Query Neighborhood Hits	1931	Target Neighborhood Hits	283	Shared Neighborhood Hits	79
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BMR1A_HUMAN
θ value	8.99809 (rank : 1826)	NC score	0.593574 (rank : 777)
Query Neighborhood Hits	1931	Target Neighborhood Hits	759	Shared Neighborhood Hits	749
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BPAEA_HUMAN
θ value	8.99809 (rank : 1827)	NC score	0.004968 (rank : 1784)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1369	Shared Neighborhood Hits	103
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BRD4_HUMAN
θ value	8.99809 (rank : 1828)	NC score	0.016541 (rank : 1601)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	190
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

BT3A2_HUMAN
θ value	8.99809 (rank : 1829)	NC score	0.058004 (rank : 1311)
Query Neighborhood Hits	1931	Target Neighborhood Hits	158	Shared Neighborhood Hits	107
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

BT3A3_HUMAN
θ value	8.99809 (rank : 1830)	NC score	0.029876 (rank : 1481)
Query Neighborhood Hits	1931	Target Neighborhood Hits	233	Shared Neighborhood Hits	115
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

BTNL3_HUMAN
θ value	8.99809 (rank : 1831)	NC score	0.006549 (rank : 1758)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	53
SwissProt Accessions	Q6UXE8, Q9Y2C7	Gene names	BTNL3, BTNLR, COLF4100
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 3 precursor (Butyrophilin-like receptor).

CACB3_MOUSE
θ value	8.99809 (rank : 1832)	NC score	0.001403 (rank : 1869)
Query Neighborhood Hits	1931	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

CBP_HUMAN
θ value	8.99809 (rank : 1833)	NC score	0.025060 (rank : 1515)
Query Neighborhood Hits	1931	Target Neighborhood Hits	941	Shared Neighborhood Hits	256
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CC019_HUMAN
θ value	8.99809 (rank : 1834)	NC score	0.000842 (rank : 1888)
Query Neighborhood Hits	1931	Target Neighborhood Hits	87	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PII3, Q96CS5	Gene names	C3orf19
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf19.

CEP41_HUMAN
θ value	8.99809 (rank : 1835)	NC score	0.002413 (rank : 1840)
Query Neighborhood Hits	1931	Target Neighborhood Hits	42	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BYV8, Q7Z496, Q86TM1, Q8NFU8, Q9H6A3, Q9NPV3	Gene names	TSGA14, CEP41
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 41 kDa (Cep41 protein) (Testis-specific gene A14 protein).

CF051_HUMAN
θ value	8.99809 (rank : 1836)	NC score	0.004990 (rank : 1783)
Query Neighborhood Hits	1931	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q969F1	Gene names	C6orf51
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf51.

CNTRB_MOUSE
θ value	8.99809 (rank : 1837)	NC score	0.029488 (rank : 1483)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1029	Shared Neighborhood Hits	159
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CO2A1_MOUSE
θ value	8.99809 (rank : 1838)	NC score	0.009128 (rank : 1702)
Query Neighborhood Hits	1931	Target Neighborhood Hits	483	Shared Neighborhood Hits	163
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

COBA1_HUMAN
θ value	8.99809 (rank : 1839)	NC score	0.006718 (rank : 1755)
Query Neighborhood Hits	1931	Target Neighborhood Hits	491	Shared Neighborhood Hits	143
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

CP007_HUMAN
θ value	8.99809 (rank : 1840)	NC score	0.002890 (rank : 1825)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2B5	Gene names	C16orf7, ATPBL
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 (Protein ATP-BL).

CP053_HUMAN
θ value	8.99809 (rank : 1841)	NC score	0.003773 (rank : 1807)
Query Neighborhood Hits	1931	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BTK6	Gene names	C16orf53
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf53.

CSF3R_HUMAN
θ value	8.99809 (rank : 1842)	NC score	0.086073 (rank : 1200)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	95
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

DIDO1_HUMAN
θ value	8.99809 (rank : 1843)	NC score	0.032890 (rank : 1454)
Query Neighborhood Hits	1931	Target Neighborhood Hits	960	Shared Neighborhood Hits	269
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DOT1L_HUMAN
θ value	8.99809 (rank : 1844)	NC score	0.030057 (rank : 1478)
Query Neighborhood Hits	1931	Target Neighborhood Hits	660	Shared Neighborhood Hits	177
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

DYN3_HUMAN
θ value	8.99809 (rank : 1845)	NC score	0.002531 (rank : 1837)
Query Neighborhood Hits	1931	Target Neighborhood Hits	158	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

ECM1_HUMAN
θ value	8.99809 (rank : 1846)	NC score	0.016840 (rank : 1596)
Query Neighborhood Hits	1931	Target Neighborhood Hits	182	Shared Neighborhood Hits	77
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

EMID2_MOUSE
θ value	8.99809 (rank : 1847)	NC score	0.007890 (rank : 1729)
Query Neighborhood Hits	1931	Target Neighborhood Hits	201	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VF6, Q8K4P3	Gene names	Emid2, Col26a, Col26a1, Emu2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

EP15R_MOUSE
θ value	8.99809 (rank : 1848)	NC score	0.005496 (rank : 1778)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1135	Shared Neighborhood Hits	113
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

EPAS1_MOUSE
θ value	8.99809 (rank : 1849)	NC score	-0.002570 (rank : 1947)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

FCGR2_MOUSE
θ value	8.99809 (rank : 1850)	NC score	0.064305 (rank : 1279)
Query Neighborhood Hits	1931	Target Neighborhood Hits	105	Shared Neighborhood Hits	71
SwissProt Accessions	P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558	Gene names	Fcgr2, Fcgr2b, Ly-17
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II precursor (Fc- gamma RII) (FcRII) (IgG Fc receptor II beta) (Fc gamma receptor IIB) (Fc-gamma-RIIB) (Lymphocyte antigen Ly-17) (CD32 antigen).

FCN3_HUMAN
θ value	8.99809 (rank : 1851)	NC score	-0.003997 (rank : 1968)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	O75636, Q6IBJ5, Q8WW86	Gene names	FCN3, HAKA1
Domain Architecture
Description	Ficolin-3 precursor (Collagen/fibrinogen domain-containing protein 3) (Collagen/fibrinogen domain-containing lectin 3 p35) (Hakata antigen).

FMNL_MOUSE
θ value	8.99809 (rank : 1852)	NC score	0.012529 (rank : 1652)
Query Neighborhood Hits	1931	Target Neighborhood Hits	428	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

G3BP2_MOUSE
θ value	8.99809 (rank : 1853)	NC score	-0.001991 (rank : 1942)
Query Neighborhood Hits	1931	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

G3BP_HUMAN
θ value	8.99809 (rank : 1854)	NC score	0.000908 (rank : 1885)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	34
SwissProt Accessions	Q13283	Gene names	G3BP, G3BP1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

GC3M_MOUSE
θ value	8.99809 (rank : 1855)	NC score	0.006528 (rank : 1759)
Query Neighborhood Hits	1931	Target Neighborhood Hits	215	Shared Neighborhood Hits	44
SwissProt Accessions	P03987	Gene names
Domain Architecture
Description	Ig gamma-3 chain C region, membrane-bound form.

GC3_MOUSE
θ value	8.99809 (rank : 1856)	NC score	0.006267 (rank : 1765)
Query Neighborhood Hits	1931	Target Neighborhood Hits	212	Shared Neighborhood Hits	43
SwissProt Accessions	P22436	Gene names
Domain Architecture	No domain graphic available
Description	Ig gamma-3 chain C region, secreted form.

GCNL2_HUMAN
θ value	8.99809 (rank : 1857)	NC score	0.002622 (rank : 1835)
Query Neighborhood Hits	1931	Target Neighborhood Hits	159	Shared Neighborhood Hits	54
SwissProt Accessions	Q92830, Q9UCW1	Gene names	GCN5L2, GCN5, HGCN5
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (hsGCN5) (STAF97).

GNDS_MOUSE
θ value	8.99809 (rank : 1858)	NC score	0.002217 (rank : 1846)
Query Neighborhood Hits	1931	Target Neighborhood Hits	115	Shared Neighborhood Hits	31
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

GRIN1_HUMAN
θ value	8.99809 (rank : 1859)	NC score	0.039325 (rank : 1402)
Query Neighborhood Hits	1931	Target Neighborhood Hits	681	Shared Neighborhood Hits	210
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

HLX1_HUMAN
θ value	8.99809 (rank : 1860)	NC score	-0.015400 (rank : 2019)
Query Neighborhood Hits	1931	Target Neighborhood Hits	370	Shared Neighborhood Hits	27
SwissProt Accessions	Q14774, Q15988	Gene names	HLX1
Domain Architecture
Description	Homeobox protein HLX1 (Homeobox protein HB24).

HORN_HUMAN
θ value	8.99809 (rank : 1861)	NC score	0.001251 (rank : 1877)
Query Neighborhood Hits	1931	Target Neighborhood Hits	206	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

HPLN4_HUMAN
θ value	8.99809 (rank : 1862)	NC score	0.020419 (rank : 1548)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	Q86UW8, Q96PW2	Gene names	HAPLN4, BRAL2, KIAA1926
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2).

HV1B_HUMAN
θ value	8.99809 (rank : 1863)	NC score	-0.004465 (rank : 1975)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	54
SwissProt Accessions	P01743	Gene names
Domain Architecture
Description	Ig heavy chain V-I region HG3 precursor.

HXC5_MOUSE
θ value	8.99809 (rank : 1864)	NC score	-0.014404 (rank : 2017)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	24
SwissProt Accessions	P32043, Q8BJW4	Gene names	Hoxc5, Hox-3.4, Hoxc-5
Domain Architecture
Description	Homeobox protein Hox-C5 (Hox-3.4) (Hox-6.2).

IGX1_MOUSE
θ value	8.99809 (rank : 1865)	NC score	0.011349 (rank : 1671)
Query Neighborhood Hits	1931	Target Neighborhood Hits	44	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R0A6	Gene names
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain protein MGC33530 precursor.

IL3RB_MOUSE
θ value	8.99809 (rank : 1866)	NC score	0.014480 (rank : 1621)
Query Neighborhood Hits	1931	Target Neighborhood Hits	355	Shared Neighborhood Hits	143
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

IQEC3_MOUSE
θ value	8.99809 (rank : 1867)	NC score	0.007069 (rank : 1749)
Query Neighborhood Hits	1931	Target Neighborhood Hits	274	Shared Neighborhood Hits	93
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

IRX1_HUMAN
θ value	8.99809 (rank : 1868)	NC score	-0.005760 (rank : 1995)
Query Neighborhood Hits	1931	Target Neighborhood Hits	285	Shared Neighborhood Hits	32
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

KLF2_HUMAN
θ value	8.99809 (rank : 1869)	NC score	-0.026606 (rank : 2051)
Query Neighborhood Hits	1931	Target Neighborhood Hits	755	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y5W3, Q9UJS5, Q9UKR6	Gene names	KLF2, LKLF
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 2 (Lung krueppel-like factor).

KV1M_HUMAN
θ value	8.99809 (rank : 1870)	NC score	-0.004502 (rank : 1977)
Query Neighborhood Hits	1931	Target Neighborhood Hits	249	Shared Neighborhood Hits	63
SwissProt Accessions	P01605	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Lay.

KV3F_HUMAN
θ value	8.99809 (rank : 1871)	NC score	-0.006771 (rank : 1999)
Query Neighborhood Hits	1931	Target Neighborhood Hits	283	Shared Neighborhood Hits	70
SwissProt Accessions	P01624	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-III region POM.

KV5M_MOUSE
θ value	8.99809 (rank : 1872)	NC score	-0.006581 (rank : 1997)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	49
SwissProt Accessions	P01646	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region HP 123E6.

KV5O_MOUSE
θ value	8.99809 (rank : 1873)	NC score	-0.004670 (rank : 1979)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	55
SwissProt Accessions	P01648	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region HP 91A3.

LAG3_HUMAN
θ value	8.99809 (rank : 1874)	NC score	0.102397 (rank : 1163)
Query Neighborhood Hits	1931	Target Neighborhood Hits	129	Shared Neighborhood Hits	89
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

LEG3_HUMAN
θ value	8.99809 (rank : 1875)	NC score	0.000855 (rank : 1887)
Query Neighborhood Hits	1931	Target Neighborhood Hits	124	Shared Neighborhood Hits	46
SwissProt Accessions	P17931, Q16005, Q96J47	Gene names	LGALS3, MAC2
Domain Architecture
Description	Galectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-binding protein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Laminin-binding protein) (Lectin L-29) (L-31) (Galactoside-binding protein) (GALBP).

LIPS_HUMAN
θ value	8.99809 (rank : 1876)	NC score	0.018163 (rank : 1582)
Query Neighborhood Hits	1931	Target Neighborhood Hits	314	Shared Neighborhood Hits	106
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

LV2B_HUMAN
θ value	8.99809 (rank : 1877)	NC score	-0.004866 (rank : 1983)
Query Neighborhood Hits	1931	Target Neighborhood Hits	234	Shared Neighborhood Hits	53
SwissProt Accessions	P01705	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region NEI.

LV6D_HUMAN
θ value	8.99809 (rank : 1878)	NC score	-0.005169 (rank : 1989)
Query Neighborhood Hits	1931	Target Neighborhood Hits	268	Shared Neighborhood Hits	54
SwissProt Accessions	P06318	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-VI region WLT.

MBD1_HUMAN
θ value	8.99809 (rank : 1879)	NC score	0.000646 (rank : 1890)
Query Neighborhood Hits	1931	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UIS9, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9	Gene names	MBD1, PCM1
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1).

MMP9_MOUSE
θ value	8.99809 (rank : 1880)	NC score	-0.000889 (rank : 1923)
Query Neighborhood Hits	1931	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

MSRB2_HUMAN
θ value	8.99809 (rank : 1881)	NC score	0.003192 (rank : 1817)
Query Neighborhood Hits	1931	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3D2, Q9Y5W6	Gene names	MSRB2, MSRB
Domain Architecture
Description	Methionine-R-sulfoxide reductase B2 (EC 1.8.4.-).

MUC7_HUMAN
θ value	8.99809 (rank : 1882)	NC score	0.038166 (rank : 1408)
Query Neighborhood Hits	1931	Target Neighborhood Hits	538	Shared Neighborhood Hits	158
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MYO15_HUMAN
θ value	8.99809 (rank : 1883)	NC score	0.018187 (rank : 1580)
Query Neighborhood Hits	1931	Target Neighborhood Hits	671	Shared Neighborhood Hits	228
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NIN_HUMAN
θ value	8.99809 (rank : 1884)	NC score	0.012805 (rank : 1643)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1416	Shared Neighborhood Hits	134
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NOTC2_MOUSE
θ value	8.99809 (rank : 1885)	NC score	0.003153 (rank : 1818)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1069	Shared Neighborhood Hits	151
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NUP53_MOUSE
θ value	8.99809 (rank : 1886)	NC score	0.006411 (rank : 1761)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

PARD3_MOUSE
θ value	8.99809 (rank : 1887)	NC score	-0.000465 (rank : 1913)
Query Neighborhood Hits	1931	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

PC11X_HUMAN
θ value	8.99809 (rank : 1888)	NC score	-0.013390 (rank : 2015)
Query Neighborhood Hits	1931	Target Neighborhood Hits	199	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZA7, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5	Gene names	PCDH11X, PCDH11, PCDHX
Domain Architecture	No domain graphic available
Description	Protocadherin-11 X-linked precursor (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S).

PCOC1_HUMAN
θ value	8.99809 (rank : 1889)	NC score	-0.004691 (rank : 1980)
Query Neighborhood Hits	1931	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

PER3_MOUSE
θ value	8.99809 (rank : 1890)	NC score	0.002668 (rank : 1832)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PHC2_HUMAN
θ value	8.99809 (rank : 1891)	NC score	0.017497 (rank : 1590)
Query Neighborhood Hits	1931	Target Neighborhood Hits	388	Shared Neighborhood Hits	136
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

PKHA4_HUMAN
θ value	8.99809 (rank : 1892)	NC score	0.012981 (rank : 1641)
Query Neighborhood Hits	1931	Target Neighborhood Hits	283	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PO210_MOUSE
θ value	8.99809 (rank : 1893)	NC score	0.001772 (rank : 1859)
Query Neighborhood Hits	1931	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QY81, Q3U031, Q69ZW2, Q7TQM1	Gene names	Nup210, Kiaa0906
Domain Architecture	No domain graphic available
Description	Nuclear pore membrane glycoprotein 210 precursor (POM210) (Nuclear pore protein gp210).

PO6F2_MOUSE
θ value	8.99809 (rank : 1894)	NC score	-0.004970 (rank : 1984)
Query Neighborhood Hits	1931	Target Neighborhood Hits	639	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PPOX_MOUSE
θ value	8.99809 (rank : 1895)	NC score	0.001362 (rank : 1872)
Query Neighborhood Hits	1931	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	P51175, P97344, Q99M34	Gene names	Ppox
Domain Architecture
Description	Protoporphyrinogen oxidase (EC 1.3.3.4) (PPO).

PRG4_MOUSE
θ value	8.99809 (rank : 1896)	NC score	0.033847 (rank : 1444)
Query Neighborhood Hits	1931	Target Neighborhood Hits	624	Shared Neighborhood Hits	154
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RGS12_HUMAN
θ value	8.99809 (rank : 1897)	NC score	-0.000921 (rank : 1924)
Query Neighborhood Hits	1931	Target Neighborhood Hits	333	Shared Neighborhood Hits	73
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

S28A2_HUMAN
θ value	8.99809 (rank : 1898)	NC score	0.001285 (rank : 1876)
Query Neighborhood Hits	1931	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	O43868, O43239	Gene names	SLC28A2, CNT2
Domain Architecture
Description	Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Sodium/purine nucleoside co- transporter) (SPNT).

S28A2_MOUSE
θ value	8.99809 (rank : 1899)	NC score	0.001341 (rank : 1873)
Query Neighborhood Hits	1931	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O88627	Gene names	Slc28a2, Cnt2
Domain Architecture
Description	Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (Sodium/purine nucleoside cotransporter) (SPNT).

S2A4R_HUMAN
θ value	8.99809 (rank : 1900)	NC score	0.004656 (rank : 1791)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NR83, Q6F6I6, Q6F6I7, Q6GTK5, Q8TAH5, Q8WVW7, Q96QD3, Q9BV85	Gene names	SLC2A4RG, HDBP1
Domain Architecture	No domain graphic available
Description	SLC2A4 regulator (GLUT4 enhancer factor) (GEF) (Huntington disease gene regulatory region-binding protein 1) (HDBP-1).

SASH1_MOUSE
θ value	8.99809 (rank : 1901)	NC score	0.025097 (rank : 1514)
Query Neighborhood Hits	1931	Target Neighborhood Hits	263	Shared Neighborhood Hits	91
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SCN4B_HUMAN
θ value	8.99809 (rank : 1902)	NC score	0.035910 (rank : 1430)
Query Neighborhood Hits	1931	Target Neighborhood Hits	68	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWT1, Q6PIG5	Gene names	SCN4B
Domain Architecture	No domain graphic available
Description	Sodium channel beta-4 subunit precursor.

SEM3E_HUMAN
θ value	8.99809 (rank : 1903)	NC score	0.016655 (rank : 1600)
Query Neighborhood Hits	1931	Target Neighborhood Hits	73	Shared Neighborhood Hits	31
SwissProt Accessions	O15041, Q75M94, Q75M97	Gene names	SEMA3E, KIAA0331
Domain Architecture	No domain graphic available
Description	Semaphorin-3E precursor.

SEM6B_MOUSE
θ value	8.99809 (rank : 1904)	NC score	0.013857 (rank : 1625)
Query Neighborhood Hits	1931	Target Neighborhood Hits	200	Shared Neighborhood Hits	91
SwissProt Accessions	O54951	Gene names	Sema6b, Seman
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin VIB) (Sema VIB) (Semaphorin N) (Sema N).

SFR15_HUMAN
θ value	8.99809 (rank : 1905)	NC score	0.019500 (rank : 1561)
Query Neighborhood Hits	1931	Target Neighborhood Hits	368	Shared Neighborhood Hits	97
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SH2D3_MOUSE
θ value	8.99809 (rank : 1906)	NC score	0.028493 (rank : 1492)
Query Neighborhood Hits	1931	Target Neighborhood Hits	174	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SNPC4_HUMAN
θ value	8.99809 (rank : 1907)	NC score	0.030208 (rank : 1475)
Query Neighborhood Hits	1931	Target Neighborhood Hits	589	Shared Neighborhood Hits	205
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SP17_HUMAN
θ value	8.99809 (rank : 1908)	NC score	0.002824 (rank : 1827)
Query Neighborhood Hits	1931	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	Q15506, Q9BXF7	Gene names	SPA17, SP17
Domain Architecture
Description	Sperm surface protein Sp17 (Sperm autoantigenic protein 17) (Sperm protein 17) (Sp17-1).

SRA1_MOUSE
θ value	8.99809 (rank : 1909)	NC score	0.002913 (rank : 1824)
Query Neighborhood Hits	1931	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q80VJ2, Q8R0S3, Q9CWU7, Q9D973	Gene names	Sra1
Domain Architecture	No domain graphic available
Description	Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP).

SREC2_HUMAN
θ value	8.99809 (rank : 1910)	NC score	0.014734 (rank : 1619)
Query Neighborhood Hits	1931	Target Neighborhood Hits	645	Shared Neighborhood Hits	114
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SSPO_MOUSE
θ value	8.99809 (rank : 1911)	NC score	0.010847 (rank : 1675)
Query Neighborhood Hits	1931	Target Neighborhood Hits	800	Shared Neighborhood Hits	115
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

SYIM_MOUSE
θ value	8.99809 (rank : 1912)	NC score	-0.001434 (rank : 1932)
Query Neighborhood Hits	1931	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BIJ6, Q3TKT8, Q8BIJ0, Q8BIP3	Gene names	Iars2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

SYNP2_MOUSE
θ value	8.99809 (rank : 1913)	NC score	0.007596 (rank : 1735)
Query Neighborhood Hits	1931	Target Neighborhood Hits	252	Shared Neighborhood Hits	65
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

TACC3_HUMAN
θ value	8.99809 (rank : 1914)	NC score	0.014079 (rank : 1622)
Query Neighborhood Hits	1931	Target Neighborhood Hits	779	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TFEB_MOUSE
θ value	8.99809 (rank : 1915)	NC score	-0.001817 (rank : 1941)
Query Neighborhood Hits	1931	Target Neighborhood Hits	119	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

THAP3_HUMAN
θ value	8.99809 (rank : 1916)	NC score	0.000128 (rank : 1900)
Query Neighborhood Hits	1931	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WTV1, Q569K1, Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3	Gene names	THAP3
Domain Architecture
Description	THAP domain-containing protein 3.

THAP8_HUMAN
θ value	8.99809 (rank : 1917)	NC score	0.004111 (rank : 1800)
Query Neighborhood Hits	1931	Target Neighborhood Hits	35	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NA92, Q96M21	Gene names	THAP8
Domain Architecture
Description	THAP domain-containing protein 8.

TM16H_HUMAN
θ value	8.99809 (rank : 1918)	NC score	0.006775 (rank : 1754)
Query Neighborhood Hits	1931	Target Neighborhood Hits	139	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HCE9	Gene names	TMEM16H, KIAA1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

TM55B_HUMAN
θ value	8.99809 (rank : 1919)	NC score	0.001144 (rank : 1880)
Query Neighborhood Hits	1931	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q86T03, Q86U09, Q8WUC0, Q9BU67, Q9NSU8	Gene names	TMEM55B, C14orf9
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55B (EC 3.1.3.-) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase I).

TMM25_HUMAN
θ value	8.99809 (rank : 1920)	NC score	0.055064 (rank : 1331)
Query Neighborhood Hits	1931	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q86YD3, Q6UW89, Q86UA7, Q96KA6, Q96MW9	Gene names	TMEM25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

TRAIP_MOUSE
θ value	8.99809 (rank : 1921)	NC score	0.000285 (rank : 1897)
Query Neighborhood Hits	1931	Target Neighborhood Hits	745	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

TRML2_MOUSE
θ value	8.99809 (rank : 1922)	NC score	0.006177 (rank : 1768)
Query Neighborhood Hits	1931	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q2LA85	Gene names	Treml2, Tlt2
Domain Architecture	No domain graphic available
Description	Trem-like transcript 2 protein precursor (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2).

VSX1_MOUSE
θ value	8.99809 (rank : 1923)	NC score	-0.013132 (rank : 2014)
Query Neighborhood Hits	1931	Target Neighborhood Hits	356	Shared Neighborhood Hits	26
SwissProt Accessions	Q91V10	Gene names	Vsx1, Rinx
Domain Architecture
Description	Visual system homeobox 1 (Transcription factor VSX1) (Retinal inner nuclear layer homeobox protein) (Homeodomain protein RINX).

WDR43_HUMAN
θ value	8.99809 (rank : 1924)	NC score	-0.008342 (rank : 2003)
Query Neighborhood Hits	1931	Target Neighborhood Hits	269	Shared Neighborhood Hits	14
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

ZDHC8_MOUSE
θ value	8.99809 (rank : 1925)	NC score	0.001422 (rank : 1868)
Query Neighborhood Hits	1931	Target Neighborhood Hits	243	Shared Neighborhood Hits	90
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

ZEP2_MOUSE
θ value	8.99809 (rank : 1926)	NC score	-0.019488 (rank : 2026)
Query Neighborhood Hits	1931	Target Neighborhood Hits	964	Shared Neighborhood Hits	127
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

ZIMP7_MOUSE
θ value	8.99809 (rank : 1927)	NC score	0.013447 (rank : 1632)
Query Neighborhood Hits	1931	Target Neighborhood Hits	566	Shared Neighborhood Hits	206
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZN185_HUMAN
θ value	8.99809 (rank : 1928)	NC score	0.000434 (rank : 1893)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	20
SwissProt Accessions	O15231, O00345, Q9NSD2	Gene names	ZNF185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein ZNF185) (P1-A).

ZN219_HUMAN
θ value	8.99809 (rank : 1929)	NC score	-0.022536 (rank : 2029)
Query Neighborhood Hits	1931	Target Neighborhood Hits	876	Shared Neighborhood Hits	111
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

ZN410_HUMAN
θ value	8.99809 (rank : 1930)	NC score	-0.027672 (rank : 2057)
Query Neighborhood Hits	1931	Target Neighborhood Hits	716	Shared Neighborhood Hits	43
SwissProt Accessions	Q86VK4, O00153, Q9BQ19	Gene names	ZNF410, APA1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 410 (Zinc finger protein APA-1) (Another partner for ARF 1).

ZYX_HUMAN
θ value	8.99809 (rank : 1931)	NC score	0.004690 (rank : 1790)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	85
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

AMGO2_HUMAN
θ value	θ > 10 (rank : 1932)	NC score	0.066883 (rank : 1271)
Query Neighborhood Hits	1931	Target Neighborhood Hits	357	Shared Neighborhood Hits	137
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

AMGO2_MOUSE
θ value	θ > 10 (rank : 1933)	NC score	0.057794 (rank : 1316)
Query Neighborhood Hits	1931	Target Neighborhood Hits	329	Shared Neighborhood Hits	108
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

AMGO3_HUMAN
θ value	θ > 10 (rank : 1934)	NC score	0.053284 (rank : 1342)
Query Neighborhood Hits	1931	Target Neighborhood Hits	276	Shared Neighborhood Hits	84
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

ARHG2_HUMAN
θ value	θ > 10 (rank : 1935)	NC score	0.055363 (rank : 1330)
Query Neighborhood Hits	1931	Target Neighborhood Hits	142	Shared Neighborhood Hits	73
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 1936)	NC score	0.056137 (rank : 1327)
Query Neighborhood Hits	1931	Target Neighborhood Hits	120	Shared Neighborhood Hits	66
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHGA_HUMAN
θ value	θ > 10 (rank : 1937)	NC score	0.075562 (rank : 1239)
Query Neighborhood Hits	1931	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGC_HUMAN
θ value	θ > 10 (rank : 1938)	NC score	0.051015 (rank : 1352)
Query Neighborhood Hits	1931	Target Neighborhood Hits	351	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 1939)	NC score	0.061641 (rank : 1296)
Query Neighborhood Hits	1931	Target Neighborhood Hits	129	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 1940)	NC score	0.057608 (rank : 1317)
Query Neighborhood Hits	1931	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BTNL2_HUMAN
θ value	θ > 10 (rank : 1941)	NC score	0.072525 (rank : 1247)
Query Neighborhood Hits	1931	Target Neighborhood Hits	164	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

BUB1B_HUMAN
θ value	θ > 10 (rank : 1942)	NC score	0.096215 (rank : 1175)
Query Neighborhood Hits	1931	Target Neighborhood Hits	208	Shared Neighborhood Hits	120
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1B_MOUSE
θ value	θ > 10 (rank : 1943)	NC score	0.075957 (rank : 1237)
Query Neighborhood Hits	1931	Target Neighborhood Hits	202	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

BUB1_HUMAN
θ value	θ > 10 (rank : 1944)	NC score	0.378167 (rank : 910)
Query Neighborhood Hits	1931	Target Neighborhood Hits	543	Shared Neighborhood Hits	412
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

CD226_HUMAN
θ value	θ > 10 (rank : 1945)	NC score	0.054544 (rank : 1337)
Query Neighborhood Hits	1931	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

CD244_HUMAN
θ value	θ > 10 (rank : 1946)	NC score	0.050874 (rank : 1354)
Query Neighborhood Hits	1931	Target Neighborhood Hits	72	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BZW8, Q96T47, Q9NQD2, Q9NQD3, Q9Y288	Gene names	CD244, 2B4
Domain Architecture
Description	Natural killer cell receptor 2B4 precursor (NKR2B4) (NK cell type I receptor protein 2B4) (h2B4) (CD244 antigen) (NK cell activation- inducing ligand) (NAIL).

CD276_MOUSE
θ value	θ > 10 (rank : 1947)	NC score	0.152652 (rank : 1077)
Query Neighborhood Hits	1931	Target Neighborhood Hits	243	Shared Neighborhood Hits	184
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CD48_HUMAN
θ value	θ > 10 (rank : 1948)	NC score	0.054814 (rank : 1333)
Query Neighborhood Hits	1931	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	P09326	Gene names	CD48, BCM1, BLAST1
Domain Architecture	No domain graphic available
Description	CD48 antigen precursor (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (TCT.1).

CD79A_HUMAN
θ value	θ > 10 (rank : 1949)	NC score	0.089185 (rank : 1194)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	71
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

CD80_HUMAN
θ value	θ > 10 (rank : 1950)	NC score	0.098292 (rank : 1170)
Query Neighborhood Hits	1931	Target Neighborhood Hits	129	Shared Neighborhood Hits	110
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

CEAM3_HUMAN
θ value	θ > 10 (rank : 1951)	NC score	0.061107 (rank : 1299)
Query Neighborhood Hits	1931	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	P40198	Gene names	CEACAM3, CD66D, CGM1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 precursor (Carcinoembryonic antigen CGM1) (CD66d antigen).

CEAMA_MOUSE
θ value	θ > 10 (rank : 1952)	NC score	0.062183 (rank : 1294)
Query Neighborhood Hits	1931	Target Neighborhood Hits	41	Shared Neighborhood Hits	35
SwissProt Accessions	Q61400, Q99LD6, Q9D329	Gene names	Ceacam10, Cea10
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 10 precursor (CEA-related cell adhesion molecule 10) (Carcinoembryonic antigen 10) (CEA10).

CHIN_HUMAN
θ value	θ > 10 (rank : 1953)	NC score	0.070068 (rank : 1254)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1954)	NC score	0.070794 (rank : 1251)
Query Neighborhood Hits	1931	Target Neighborhood Hits	229	Shared Neighborhood Hits	79
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1955)	NC score	0.071442 (rank : 1250)
Query Neighborhood Hits	1931	Target Neighborhood Hits	220	Shared Neighborhood Hits	76
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 1956)	NC score	0.064283 (rank : 1280)
Query Neighborhood Hits	1931	Target Neighborhood Hits	130	Shared Neighborhood Hits	49
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

COEA1_HUMAN
θ value	θ > 10 (rank : 1957)	NC score	0.083306 (rank : 1210)
Query Neighborhood Hits	1931	Target Neighborhood Hits	427	Shared Neighborhood Hits	196
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

COEA1_MOUSE
θ value	θ > 10 (rank : 1958)	NC score	0.098006 (rank : 1173)
Query Neighborhood Hits	1931	Target Neighborhood Hits	402	Shared Neighborhood Hits	183
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

CRKL_HUMAN
θ value	θ > 10 (rank : 1959)	NC score	0.056709 (rank : 1323)
Query Neighborhood Hits	1931	Target Neighborhood Hits	313	Shared Neighborhood Hits	88
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 1960)	NC score	0.057117 (rank : 1322)
Query Neighborhood Hits	1931	Target Neighborhood Hits	307	Shared Neighborhood Hits	84
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRLF1_HUMAN
θ value	θ > 10 (rank : 1961)	NC score	0.050280 (rank : 1359)
Query Neighborhood Hits	1931	Target Neighborhood Hits	122	Shared Neighborhood Hits	73
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

CT075_MOUSE
θ value	θ > 10 (rank : 1962)	NC score	0.059544 (rank : 1304)
Query Neighborhood Hits	1931	Target Neighborhood Hits	358	Shared Neighborhood Hits	108
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

DAPP1_HUMAN
θ value	θ > 10 (rank : 1963)	NC score	0.051950 (rank : 1348)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 1964)	NC score	0.050687 (rank : 1356)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCX_HUMAN
θ value	θ > 10 (rank : 1965)	NC score	0.066022 (rank : 1275)
Query Neighborhood Hits	1931	Target Neighborhood Hits	141	Shared Neighborhood Hits	57
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCX_MOUSE
θ value	θ > 10 (rank : 1966)	NC score	0.061641 (rank : 1295)
Query Neighborhood Hits	1931	Target Neighborhood Hits	124	Shared Neighborhood Hits	36
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DGKD_HUMAN
θ value	θ > 10 (rank : 1967)	NC score	0.070424 (rank : 1253)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	98
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1968)	NC score	0.066974 (rank : 1269)
Query Neighborhood Hits	1931	Target Neighborhood Hits	255	Shared Neighborhood Hits	91
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1969)	NC score	0.062859 (rank : 1292)
Query Neighborhood Hits	1931	Target Neighborhood Hits	131	Shared Neighborhood Hits	48
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

ECT2_HUMAN
θ value	θ > 10 (rank : 1970)	NC score	0.075488 (rank : 1240)
Query Neighborhood Hits	1931	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 1971)	NC score	0.077271 (rank : 1233)
Query Neighborhood Hits	1931	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FARP2_MOUSE
θ value	θ > 10 (rank : 1972)	NC score	0.057891 (rank : 1314)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FCG3B_HUMAN
θ value	θ > 10 (rank : 1973)	NC score	0.068711 (rank : 1263)
Query Neighborhood Hits	1931	Target Neighborhood Hits	67	Shared Neighborhood Hits	63
SwissProt Accessions	O75015	Gene names	FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-B precursor (IgG Fc receptor III-1) (Fc-gamma RIII-beta) (Fc-gamma RIIIb) (FcRIIIb) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16b antigen).

FCGR3_MOUSE
θ value	θ > 10 (rank : 1974)	NC score	0.054617 (rank : 1336)
Query Neighborhood Hits	1931	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	P08508	Gene names	Fcgr3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III precursor (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII).

GRAP2_HUMAN
θ value	θ > 10 (rank : 1975)	NC score	0.082961 (rank : 1212)
Query Neighborhood Hits	1931	Target Neighborhood Hits	304	Shared Neighborhood Hits	85
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1976)	NC score	0.081714 (rank : 1218)
Query Neighborhood Hits	1931	Target Neighborhood Hits	297	Shared Neighborhood Hits	84
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1977)	NC score	0.087553 (rank : 1197)
Query Neighborhood Hits	1931	Target Neighborhood Hits	307	Shared Neighborhood Hits	92
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1978)	NC score	0.086454 (rank : 1199)
Query Neighborhood Hits	1931	Target Neighborhood Hits	309	Shared Neighborhood Hits	90
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 1979)	NC score	0.082877 (rank : 1213)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	87
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1980)	NC score	0.082821 (rank : 1215)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	87
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 1981)	NC score	0.095452 (rank : 1177)
Query Neighborhood Hits	1931	Target Neighborhood Hits	131	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GUC2G_MOUSE
θ value	θ > 10 (rank : 1982)	NC score	0.432372 (rank : 834)
Query Neighborhood Hits	1931	Target Neighborhood Hits	644	Shared Neighborhood Hits	585
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HCFC2_MOUSE
θ value	θ > 10 (rank : 1983)	NC score	0.108044 (rank : 1142)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

I12R1_HUMAN
θ value	θ > 10 (rank : 1984)	NC score	0.063387 (rank : 1289)
Query Neighborhood Hits	1931	Target Neighborhood Hits	78	Shared Neighborhood Hits	56
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

I12R1_MOUSE
θ value	θ > 10 (rank : 1985)	NC score	0.050962 (rank : 1353)
Query Neighborhood Hits	1931	Target Neighborhood Hits	70	Shared Neighborhood Hits	49
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

I12R2_HUMAN
θ value	θ > 10 (rank : 1986)	NC score	0.107915 (rank : 1143)
Query Neighborhood Hits	1931	Target Neighborhood Hits	163	Shared Neighborhood Hits	105
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

I12R2_MOUSE
θ value	θ > 10 (rank : 1987)	NC score	0.106543 (rank : 1148)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	99
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

ICAM1_MOUSE
θ value	θ > 10 (rank : 1988)	NC score	0.091632 (rank : 1191)
Query Neighborhood Hits	1931	Target Neighborhood Hits	99	Shared Neighborhood Hits	88
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

ICAM3_HUMAN
θ value	θ > 10 (rank : 1989)	NC score	0.079654 (rank : 1225)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

ICOSL_MOUSE
θ value	θ > 10 (rank : 1990)	NC score	0.050559 (rank : 1358)
Query Neighborhood Hits	1931	Target Neighborhood Hits	93	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

IL1AP_HUMAN
θ value	θ > 10 (rank : 1991)	NC score	0.051307 (rank : 1351)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NPH3, O14915, Q86WJ7	Gene names	IL1RAP
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

IL1AP_MOUSE
θ value	θ > 10 (rank : 1992)	NC score	0.061515 (rank : 1298)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	62
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

IL27B_HUMAN
θ value	θ > 10 (rank : 1993)	NC score	0.065532 (rank : 1277)
Query Neighborhood Hits	1931	Target Neighborhood Hits	80	Shared Neighborhood Hits	59
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

IL6RB_HUMAN
θ value	θ > 10 (rank : 1994)	NC score	0.140353 (rank : 1090)
Query Neighborhood Hits	1931	Target Neighborhood Hits	181	Shared Neighborhood Hits	117
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

IL6RB_MOUSE
θ value	θ > 10 (rank : 1995)	NC score	0.122064 (rank : 1121)
Query Neighborhood Hits	1931	Target Neighborhood Hits	168	Shared Neighborhood Hits	115
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

IRAK2_HUMAN
θ value	θ > 10 (rank : 1996)	NC score	0.611014 (rank : 761)
Query Neighborhood Hits	1931	Target Neighborhood Hits	714	Shared Neighborhood Hits	685
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ITB4_HUMAN
θ value	θ > 10 (rank : 1997)	NC score	0.125147 (rank : 1112)
Query Neighborhood Hits	1931	Target Neighborhood Hits	458	Shared Neighborhood Hits	159
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

JAML1_MOUSE
θ value	θ > 10 (rank : 1998)	NC score	0.112602 (rank : 1134)
Query Neighborhood Hits	1931	Target Neighborhood Hits	185	Shared Neighborhood Hits	136
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

KALM_HUMAN
θ value	θ > 10 (rank : 1999)	NC score	0.111511 (rank : 1137)
Query Neighborhood Hits	1931	Target Neighborhood Hits	114	Shared Neighborhood Hits	72
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

LIFR_HUMAN
θ value	θ > 10 (rank : 2000)	NC score	0.110606 (rank : 1139)
Query Neighborhood Hits	1931	Target Neighborhood Hits	130	Shared Neighborhood Hits	84
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

LIFR_MOUSE
θ value	θ > 10 (rank : 2001)	NC score	0.102529 (rank : 1160)
Query Neighborhood Hits	1931	Target Neighborhood Hits	127	Shared Neighborhood Hits	82
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

MDC1_HUMAN
θ value	θ > 10 (rank : 2002)	NC score	0.050621 (rank : 1357)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1446	Shared Neighborhood Hits	315
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MOX2R_HUMAN
θ value	θ > 10 (rank : 2003)	NC score	0.069524 (rank : 1259)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

MUC1_HUMAN
θ value	θ > 10 (rank : 2004)	NC score	0.052405 (rank : 1347)
Query Neighborhood Hits	1931	Target Neighborhood Hits	975	Shared Neighborhood Hits	327
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NCK1_HUMAN
θ value	θ > 10 (rank : 2005)	NC score	0.078668 (rank : 1229)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	84
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 2006)	NC score	0.078298 (rank : 1231)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	85
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NGEF_HUMAN
θ value	θ > 10 (rank : 2007)	NC score	0.057487 (rank : 1318)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 2008)	NC score	0.060583 (rank : 1302)
Query Neighborhood Hits	1931	Target Neighborhood Hits	228	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NTKL_HUMAN
θ value	θ > 10 (rank : 2009)	NC score	0.257335 (rank : 999)
Query Neighborhood Hits	1931	Target Neighborhood Hits	266	Shared Neighborhood Hits	230
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

NTKL_MOUSE
θ value	θ > 10 (rank : 2010)	NC score	0.335109 (rank : 939)
Query Neighborhood Hits	1931	Target Neighborhood Hits	326	Shared Neighborhood Hits	298
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

OX2G_HUMAN
θ value	θ > 10 (rank : 2011)	NC score	0.085125 (rank : 1204)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

OX2G_MOUSE
θ value	θ > 10 (rank : 2012)	NC score	0.098334 (rank : 1169)
Query Neighborhood Hits	1931	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

P85B_MOUSE
θ value	θ > 10 (rank : 2013)	NC score	0.050032 (rank : 1362)
Query Neighborhood Hits	1931	Target Neighborhood Hits	519	Shared Neighborhood Hits	98
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACE1_HUMAN
θ value	θ > 10 (rank : 2014)	NC score	0.063837 (rank : 1286)
Query Neighborhood Hits	1931	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PACE1_MOUSE
θ value	θ > 10 (rank : 2015)	NC score	0.066386 (rank : 1272)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	61
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PDL2_HUMAN
θ value	θ > 10 (rank : 2016)	NC score	0.093956 (rank : 1180)
Query Neighborhood Hits	1931	Target Neighborhood Hits	114	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

PDZD8_HUMAN
θ value	θ > 10 (rank : 2017)	NC score	0.074172 (rank : 1243)
Query Neighborhood Hits	1931	Target Neighborhood Hits	185	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PLCG1_HUMAN
θ value	θ > 10 (rank : 2018)	NC score	0.052613 (rank : 1346)
Query Neighborhood Hits	1931	Target Neighborhood Hits	293	Shared Neighborhood Hits	82
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 2019)	NC score	0.053036 (rank : 1343)
Query Neighborhood Hits	1931	Target Neighborhood Hits	314	Shared Neighborhood Hits	84
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PRPK_HUMAN
θ value	θ > 10 (rank : 2020)	NC score	0.143354 (rank : 1087)
Query Neighborhood Hits	1931	Target Neighborhood Hits	131	Shared Neighborhood Hits	129
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 2021)	NC score	0.141427 (rank : 1088)
Query Neighborhood Hits	1931	Target Neighborhood Hits	139	Shared Neighborhood Hits	133
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PTPRK_HUMAN
θ value	θ > 10 (rank : 2022)	NC score	0.083040 (rank : 1211)
Query Neighborhood Hits	1931	Target Neighborhood Hits	228	Shared Neighborhood Hits	131
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	θ > 10 (rank : 2023)	NC score	0.084186 (rank : 1207)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	131
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PVR_HUMAN
θ value	θ > 10 (rank : 2024)	NC score	0.136761 (rank : 1095)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	152
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

PXK_HUMAN
θ value	θ > 10 (rank : 2025)	NC score	0.123659 (rank : 1115)
Query Neighborhood Hits	1931	Target Neighborhood Hits	216	Shared Neighborhood Hits	145
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 2026)	NC score	0.165091 (rank : 1059)
Query Neighborhood Hits	1931	Target Neighborhood Hits	320	Shared Neighborhood Hits	216
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RASA1_HUMAN
θ value	θ > 10 (rank : 2027)	NC score	0.057479 (rank : 1319)
Query Neighborhood Hits	1931	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_HUMAN
θ value	θ > 10 (rank : 2028)	NC score	0.058220 (rank : 1310)
Query Neighborhood Hits	1931	Target Neighborhood Hits	62	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 2029)	NC score	0.071979 (rank : 1249)
Query Neighborhood Hits	1931	Target Neighborhood Hits	74	Shared Neighborhood Hits	37
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RGNEF_MOUSE
θ value	θ > 10 (rank : 2030)	NC score	0.073407 (rank : 1244)
Query Neighborhood Hits	1931	Target Neighborhood Hits	641	Shared Neighborhood Hits	151
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RIMB2_HUMAN
θ value	θ > 10 (rank : 2031)	NC score	0.063275 (rank : 1290)
Query Neighborhood Hits	1931	Target Neighborhood Hits	263	Shared Neighborhood Hits	98
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 2032)	NC score	0.059470 (rank : 1305)
Query Neighborhood Hits	1931	Target Neighborhood Hits	246	Shared Neighborhood Hits	89
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RN5A_HUMAN
θ value	θ > 10 (rank : 2033)	NC score	0.137776 (rank : 1092)
Query Neighborhood Hits	1931	Target Neighborhood Hits	608	Shared Neighborhood Hits	336
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

SH21A_HUMAN
θ value	θ > 10 (rank : 2034)	NC score	0.054023 (rank : 1340)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	39
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 2035)	NC score	0.058460 (rank : 1309)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	40
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 2036)	NC score	0.057410 (rank : 1320)
Query Neighborhood Hits	1931	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 2037)	NC score	0.064109 (rank : 1282)
Query Neighborhood Hits	1931	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SIGL9_HUMAN
θ value	θ > 10 (rank : 2038)	NC score	0.072621 (rank : 1246)
Query Neighborhood Hits	1931	Target Neighborhood Hits	76	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

SLAP1_HUMAN
θ value	θ > 10 (rank : 2039)	NC score	0.093926 (rank : 1181)
Query Neighborhood Hits	1931	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 2040)	NC score	0.092593 (rank : 1185)
Query Neighborhood Hits	1931	Target Neighborhood Hits	117	Shared Neighborhood Hits	45
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 2041)	NC score	0.095468 (rank : 1176)
Query Neighborhood Hits	1931	Target Neighborhood Hits	139	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 2042)	NC score	0.098681 (rank : 1168)
Query Neighborhood Hits	1931	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SORL_HUMAN
θ value	θ > 10 (rank : 2043)	NC score	0.076355 (rank : 1235)
Query Neighborhood Hits	1931	Target Neighborhood Hits	440	Shared Neighborhood Hits	126
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

SORL_MOUSE
θ value	θ > 10 (rank : 2044)	NC score	0.075040 (rank : 1241)
Query Neighborhood Hits	1931	Target Neighborhood Hits	439	Shared Neighborhood Hits	128
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

SRRM1_HUMAN
θ value	θ > 10 (rank : 2045)	NC score	0.050255 (rank : 1360)
Query Neighborhood Hits	1931	Target Neighborhood Hits	690	Shared Neighborhood Hits	180
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 2046)	NC score	0.068099 (rank : 1266)
Query Neighborhood Hits	1931	Target Neighborhood Hits	966	Shared Neighborhood Hits	276
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

STAC3_HUMAN
θ value	θ > 10 (rank : 2047)	NC score	0.094544 (rank : 1179)
Query Neighborhood Hits	1931	Target Neighborhood Hits	228	Shared Neighborhood Hits	97
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 2048)	NC score	0.095404 (rank : 1178)
Query Neighborhood Hits	1931	Target Neighborhood Hits	232	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 2049)	NC score	0.092260 (rank : 1186)
Query Neighborhood Hits	1931	Target Neighborhood Hits	276	Shared Neighborhood Hits	108
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 2050)	NC score	0.097600 (rank : 1174)
Query Neighborhood Hits	1931	Target Neighborhood Hits	268	Shared Neighborhood Hits	108
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

TARSH_HUMAN
θ value	θ > 10 (rank : 2051)	NC score	0.112351 (rank : 1135)
Query Neighborhood Hits	1931	Target Neighborhood Hits	768	Shared Neighborhood Hits	302
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TENA_HUMAN
θ value	θ > 10 (rank : 2052)	NC score	0.055524 (rank : 1329)
Query Neighborhood Hits	1931	Target Neighborhood Hits	631	Shared Neighborhood Hits	141
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TENN_HUMAN
θ value	θ > 10 (rank : 2053)	NC score	0.072131 (rank : 1248)
Query Neighborhood Hits	1931	Target Neighborhood Hits	453	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TENN_MOUSE
θ value	θ > 10 (rank : 2054)	NC score	0.084729 (rank : 1206)
Query Neighborhood Hits	1931	Target Neighborhood Hits	484	Shared Neighborhood Hits	140
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TMM25_MOUSE
θ value	θ > 10 (rank : 2055)	NC score	0.054532 (rank : 1338)
Query Neighborhood Hits	1931	Target Neighborhood Hits	46	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DCF1, Q3TMP3, Q6PAK7	Gene names	Tmem25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

TPSNR_MOUSE
θ value	θ > 10 (rank : 2056)	NC score	0.060957 (rank : 1300)
Query Neighborhood Hits	1931	Target Neighborhood Hits	336	Shared Neighborhood Hits	141
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

UN13A_HUMAN
θ value	θ > 10 (rank : 2057)	NC score	0.069983 (rank : 1256)
Query Neighborhood Hits	1931	Target Neighborhood Hits	285	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 2058)	NC score	0.067483 (rank : 1268)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	63
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 2059)	NC score	0.065258 (rank : 1278)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

Hits sorted by NC score

OBSCN_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1931	Shared Neighborhood Hits	1931
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

MYLK_HUMAN
NC score	0.945789 (rank : 2)	θ value	1.72781e-51 (rank : 9)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1328	Shared Neighborhood Hits	1134
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

SPEG_HUMAN
NC score	0.943865 (rank : 3)	θ value	1.18001e-100 (rank : 5)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1762	Shared Neighborhood Hits	1244
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MYLK_MOUSE
NC score	0.943805 (rank : 4)	θ value	4.25575e-50 (rank : 11)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1489	Shared Neighborhood Hits	1195
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

SPEG_MOUSE
NC score	0.941840 (rank : 5)	θ value	5.85632e-100 (rank : 6)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1282
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

DUET_HUMAN
NC score	0.917372 (rank : 6)	θ value	4.25575e-50 (rank : 10)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1220	Shared Neighborhood Hits	1063
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TITIN_HUMAN
NC score	0.903999 (rank : 7)	θ value	0 (rank : 2)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2923	Shared Neighborhood Hits	1346
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TRIO_HUMAN
NC score	0.883924 (rank : 8)	θ value	1.15626e-55 (rank : 8)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1580	Shared Neighborhood Hits	1117
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DAPK2_MOUSE
NC score	0.861424 (rank : 9)	θ value	9.18288e-45 (rank : 14)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	824
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_MOUSE
NC score	0.861366 (rank : 10)	θ value	3.37202e-47 (rank : 12)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	821
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ST17A_HUMAN
NC score	0.861167 (rank : 11)	θ value	1.62093e-41 (rank : 19)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	817
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

DAPK2_HUMAN
NC score	0.860786 (rank : 12)	θ value	1.01529e-43 (rank : 15)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	820
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

ST17B_MOUSE
NC score	0.860027 (rank : 13)	θ value	2.76489e-41 (rank : 20)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

DAPK3_HUMAN
NC score	0.859851 (rank : 14)	θ value	4.2656e-42 (rank : 18)
Query Neighborhood Hits	1931	Target Neighborhood Hits	945	Shared Neighborhood Hits	831
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ST17B_HUMAN
NC score	0.859832 (rank : 15)	θ value	3.99248e-40 (rank : 24)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	824
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MYLK2_HUMAN
NC score	0.858165 (rank : 16)	θ value	1.73182e-43 (rank : 16)
Query Neighborhood Hits	1931	Target Neighborhood Hits	920	Shared Neighborhood Hits	853
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

KCC1B_HUMAN
NC score	0.856786 (rank : 17)	θ value	2.41655e-45 (rank : 13)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	832
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
NC score	0.856636 (rank : 18)	θ value	2.26182e-43 (rank : 17)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	832
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KPSH1_HUMAN
NC score	0.856337 (rank : 19)	θ value	1.79215e-40 (rank : 23)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	828
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
NC score	0.856313 (rank : 20)	θ value	2.58786e-39 (rank : 27)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	829
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KCC4_HUMAN
NC score	0.856275 (rank : 21)	θ value	2.96089e-35 (rank : 35)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	824
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC1A_MOUSE
NC score	0.856117 (rank : 22)	θ value	1.16164e-39 (rank : 26)
Query Neighborhood Hits	1931	Target Neighborhood Hits	845	Shared Neighborhood Hits	833
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_HUMAN
NC score	0.855974 (rank : 23)	θ value	1.16164e-39 (rank : 25)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	833
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KPSH2_HUMAN
NC score	0.855893 (rank : 24)	θ value	9.20422e-37 (rank : 30)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	814
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KCC4_MOUSE
NC score	0.855877 (rank : 25)	θ value	7.79185e-36 (rank : 34)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	830
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC1D_MOUSE
NC score	0.855728 (rank : 26)	θ value	6.15952e-41 (rank : 21)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	831
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.855625 (rank : 27)	θ value	8.04462e-41 (rank : 22)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	830
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

DCAK3_HUMAN
NC score	0.855314 (rank : 28)	θ value	5.97985e-28 (rank : 81)
Query Neighborhood Hits	1931	Target Neighborhood Hits	888	Shared Neighborhood Hits	834
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
NC score	0.854831 (rank : 29)	θ value	1.08979e-29 (rank : 58)
Query Neighborhood Hits	1931	Target Neighborhood Hits	922	Shared Neighborhood Hits	839
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KCC1G_MOUSE
NC score	0.853736 (rank : 30)	θ value	5.96599e-36 (rank : 33)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	836
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_HUMAN
NC score	0.853640 (rank : 31)	θ value	1.20211e-36 (rank : 31)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	833
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

ULK3_MOUSE
NC score	0.851938 (rank : 32)	θ value	4.42448e-31 (rank : 50)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	835
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

KCC2G_HUMAN
NC score	0.851935 (rank : 33)	θ value	5.77852e-31 (rank : 51)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	825
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
NC score	0.851934 (rank : 34)	θ value	5.77852e-31 (rank : 52)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	825
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

STK33_HUMAN
NC score	0.851807 (rank : 35)	θ value	7.30988e-26 (rank : 118)
Query Neighborhood Hits	1931	Target Neighborhood Hits	879	Shared Neighborhood Hits	838
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

CHK2_MOUSE
NC score	0.851238 (rank : 36)	θ value	1.92365e-26 (rank : 112)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

KCC2D_HUMAN
NC score	0.850920 (rank : 37)	θ value	2.19584e-30 (rank : 53)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	818
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KCC2A_HUMAN
NC score	0.850805 (rank : 38)	θ value	6.38894e-30 (rank : 57)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	818
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

CHK2_HUMAN
NC score	0.850562 (rank : 39)	θ value	9.24701e-21 (rank : 229)
Query Neighborhood Hits	1931	Target Neighborhood Hits	859	Shared Neighborhood Hits	827
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

KCC2A_MOUSE
NC score	0.850266 (rank : 40)	θ value	7.06379e-29 (rank : 69)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	816
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

ULK3_HUMAN
NC score	0.850259 (rank : 41)	θ value	6.84181e-24 (rank : 158)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PHKG2_MOUSE
NC score	0.850096 (rank : 42)	θ value	1.12775e-26 (rank : 106)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	831
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

AURKC_MOUSE
NC score	0.849931 (rank : 43)	θ value	1.92365e-26 (rank : 111)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	840
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

PHKG2_HUMAN
NC score	0.849681 (rank : 44)	θ value	7.80994e-28 (rank : 84)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	830
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

AURKC_HUMAN
NC score	0.849629 (rank : 45)	θ value	3.28125e-26 (rank : 116)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	842
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

KCC2B_HUMAN
NC score	0.849628 (rank : 46)	θ value	3.87602e-27 (rank : 93)
Query Neighborhood Hits	1931	Target Neighborhood Hits	866	Shared Neighborhood Hits	830
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

PLK4_MOUSE
NC score	0.849201 (rank : 47)	θ value	1.4233e-29 (rank : 62)
Query Neighborhood Hits	1931	Target Neighborhood Hits	879	Shared Neighborhood Hits	840
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_HUMAN
NC score	0.849171 (rank : 48)	θ value	5.97985e-28 (rank : 82)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	841
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

STK6_MOUSE
NC score	0.849166 (rank : 49)	θ value	2.35151e-24 (rank : 151)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	853
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

STK6_HUMAN
NC score	0.849129 (rank : 50)	θ value	1.92365e-26 (rank : 113)
Query Neighborhood Hits	1931	Target Neighborhood Hits	916	Shared Neighborhood Hits	860
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

PHKG1_MOUSE
NC score	0.848863 (rank : 51)	θ value	5.40856e-29 (rank : 67)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

AURKB_MOUSE
NC score	0.848710 (rank : 52)	θ value	6.84181e-24 (rank : 156)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

PHKG1_HUMAN
NC score	0.848680 (rank : 53)	θ value	3.3877e-31 (rank : 49)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	831
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

SNRK_HUMAN
NC score	0.848660 (rank : 54)	θ value	8.63488e-27 (rank : 103)
Query Neighborhood Hits	1931	Target Neighborhood Hits	855	Shared Neighborhood Hits	821
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

AURKB_HUMAN
NC score	0.848547 (rank : 55)	θ value	4.15078e-21 (rank : 220)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	840
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

HUNK_MOUSE
NC score	0.847974 (rank : 56)	θ value	1.57365e-28 (rank : 75)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	842
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

KCC2B_MOUSE
NC score	0.847974 (rank : 57)	θ value	3.87602e-27 (rank : 94)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	818
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

BRSK1_HUMAN
NC score	0.847743 (rank : 58)	θ value	7.80994e-28 (rank : 83)
Query Neighborhood Hits	1931	Target Neighborhood Hits	942	Shared Neighborhood Hits	865
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

HUNK_HUMAN
NC score	0.847576 (rank : 59)	θ value	4.57862e-28 (rank : 79)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	844
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

SNRK_MOUSE
NC score	0.847453 (rank : 60)	θ value	4.73814e-25 (rank : 133)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	822
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

NUAK2_HUMAN
NC score	0.846945 (rank : 61)	θ value	5.23862e-24 (rank : 154)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	844
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

BRSK2_HUMAN
NC score	0.846942 (rank : 62)	θ value	2.51237e-26 (rank : 114)
Query Neighborhood Hits	1931	Target Neighborhood Hits	897	Shared Neighborhood Hits	847
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

NIM1_MOUSE
NC score	0.846728 (rank : 63)	θ value	8.63488e-27 (rank : 102)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	837
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NUAK2_MOUSE
NC score	0.846387 (rank : 64)	θ value	8.93572e-24 (rank : 159)
Query Neighborhood Hits	1931	Target Neighborhood Hits	878	Shared Neighborhood Hits	846
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

NUAK1_HUMAN
NC score	0.846082 (rank : 65)	θ value	3.39556e-23 (rank : 170)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	842
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

PLK1_MOUSE
NC score	0.846069 (rank : 66)	θ value	9.56915e-18 (rank : 338)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	831
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

NUAK1_MOUSE
NC score	0.846034 (rank : 67)	θ value	5.79196e-23 (rank : 175)
Query Neighborhood Hits	1931	Target Neighborhood Hits	881	Shared Neighborhood Hits	843
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

MAPK2_HUMAN
NC score	0.845931 (rank : 68)	θ value	3.39556e-23 (rank : 169)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	818
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

KKCC2_MOUSE
NC score	0.845877 (rank : 69)	θ value	5.79196e-23 (rank : 174)
Query Neighborhood Hits	1931	Target Neighborhood Hits	855	Shared Neighborhood Hits	832
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

STK11_HUMAN
NC score	0.845875 (rank : 70)	θ value	2.35696e-16 (rank : 394)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	824
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

PLK1_HUMAN
NC score	0.845810 (rank : 71)	θ value	2.69047e-20 (rank : 243)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	831
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KKCC2_HUMAN
NC score	0.845808 (rank : 72)	θ value	5.79196e-23 (rank : 173)
Query Neighborhood Hits	1931	Target Neighborhood Hits	852	Shared Neighborhood Hits	831
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

MELK_MOUSE
NC score	0.845642 (rank : 73)	θ value	1.99067e-23 (rank : 165)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	833
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

PLK3_MOUSE
NC score	0.845636 (rank : 74)	θ value	3.62785e-25 (rank : 129)
Query Neighborhood Hits	1931	Target Neighborhood Hits	863	Shared Neighborhood Hits	842
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK3_HUMAN
NC score	0.845616 (rank : 75)	θ value	8.08199e-25 (rank : 138)
Query Neighborhood Hits	1931	Target Neighborhood Hits	865	Shared Neighborhood Hits	843
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

MELK_HUMAN
NC score	0.845583 (rank : 76)	θ value	2.35151e-24 (rank : 148)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	834
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MAPK2_MOUSE
NC score	0.845512 (rank : 77)	θ value	1.5242e-23 (rank : 163)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	814
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

STK36_HUMAN
NC score	0.845484 (rank : 78)	θ value	3.61944e-33 (rank : 42)
Query Neighborhood Hits	1931	Target Neighborhood Hits	896	Shared Neighborhood Hits	842
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

NIM1_HUMAN
NC score	0.845319 (rank : 79)	θ value	1.24688e-25 (rank : 121)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PLK2_HUMAN
NC score	0.844494 (rank : 80)	θ value	5.06226e-27 (rank : 98)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	836
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

KKCC1_MOUSE
NC score	0.844451 (rank : 81)	θ value	8.36355e-22 (rank : 201)
Query Neighborhood Hits	1931	Target Neighborhood Hits	866	Shared Neighborhood Hits	838
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_HUMAN
NC score	0.844191 (rank : 82)	θ value	2.87452e-22 (rank : 192)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	837
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PLK2_MOUSE
NC score	0.844148 (rank : 83)	θ value	5.06226e-27 (rank : 99)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	836
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MAPK3_MOUSE
NC score	0.843905 (rank : 84)	θ value	8.63488e-27 (rank : 101)
Query Neighborhood Hits	1931	Target Neighborhood Hits	811	Shared Neighborhood Hits	805
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

ULK2_MOUSE
NC score	0.843746 (rank : 85)	θ value	9.24701e-21 (rank : 231)
Query Neighborhood Hits	1931	Target Neighborhood Hits	943	Shared Neighborhood Hits	869
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK1_HUMAN
NC score	0.843467 (rank : 86)	θ value	2.87452e-22 (rank : 193)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1121	Shared Neighborhood Hits	938
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

AAPK1_HUMAN
NC score	0.843312 (rank : 87)	θ value	5.42112e-21 (rank : 225)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	832
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

ULK2_HUMAN
NC score	0.843306 (rank : 88)	θ value	4.15078e-21 (rank : 224)
Query Neighborhood Hits	1931	Target Neighborhood Hits	979	Shared Neighborhood Hits	878
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

MAPK3_HUMAN
NC score	0.843291 (rank : 89)	θ value	2.96777e-27 (rank : 90)
Query Neighborhood Hits	1931	Target Neighborhood Hits	807	Shared Neighborhood Hits	795
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

SN1L1_HUMAN
NC score	0.843261 (rank : 90)	θ value	1.08979e-29 (rank : 60)
Query Neighborhood Hits	1931	Target Neighborhood Hits	911	Shared Neighborhood Hits	853
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

AAPK1_MOUSE
NC score	0.843145 (rank : 91)	θ value	5.42112e-21 (rank : 226)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	832
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KPCD2_HUMAN
NC score	0.843134 (rank : 92)	θ value	1.62847e-25 (rank : 122)
Query Neighborhood Hits	1931	Target Neighborhood Hits	910	Shared Neighborhood Hits	843
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

SN1L1_MOUSE
NC score	0.843066 (rank : 93)	θ value	2.19584e-30 (rank : 54)
Query Neighborhood Hits	1931	Target Neighborhood Hits	895	Shared Neighborhood Hits	845
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

STK36_MOUSE
NC score	0.842890 (rank : 94)	θ value	1.08979e-29 (rank : 61)
Query Neighborhood Hits	1931	Target Neighborhood Hits	877	Shared Neighborhood Hits	841
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

K0999_MOUSE
NC score	0.842857 (rank : 95)	θ value	1.57365e-28 (rank : 76)
Query Neighborhood Hits	1931	Target Neighborhood Hits	931	Shared Neighborhood Hits	853
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

TSSK4_MOUSE
NC score	0.842700 (rank : 96)	θ value	8.93572e-24 (rank : 160)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

K0999_HUMAN
NC score	0.842691 (rank : 97)	θ value	1.2049e-28 (rank : 74)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	839
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

AAPK2_HUMAN
NC score	0.842644 (rank : 98)	θ value	5.23862e-24 (rank : 153)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	832
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

DCAK1_MOUSE
NC score	0.842630 (rank : 99)	θ value	1.2049e-28 (rank : 73)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	830
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KPCD1_HUMAN
NC score	0.842424 (rank : 100)	θ value	1.80048e-24 (rank : 143)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	840
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

DCAK2_MOUSE
NC score	0.842393 (rank : 101)	θ value	1.33217e-27 (rank : 85)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	829
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK1_HUMAN
NC score	0.842324 (rank : 102)	θ value	1.2049e-28 (rank : 72)
Query Neighborhood Hits	1931	Target Neighborhood Hits	877	Shared Neighborhood Hits	833
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

MARK4_HUMAN
NC score	0.842263 (rank : 103)	θ value	9.2256e-29 (rank : 71)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	852
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
NC score	0.842211 (rank : 104)	θ value	2.68423e-28 (rank : 77)
Query Neighborhood Hits	1931	Target Neighborhood Hits	898	Shared Neighborhood Hits	852
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

KPCD1_MOUSE
NC score	0.842149 (rank : 105)	θ value	1.80048e-24 (rank : 144)
Query Neighborhood Hits	1931	Target Neighborhood Hits	891	Shared Neighborhood Hits	841
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

DCAK2_HUMAN
NC score	0.841950 (rank : 106)	θ value	5.97985e-28 (rank : 80)
Query Neighborhood Hits	1931	Target Neighborhood Hits	862	Shared Neighborhood Hits	828
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

ULK1_MOUSE
NC score	0.841753 (rank : 107)	θ value	3.75424e-22 (rank : 196)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1214	Shared Neighborhood Hits	977
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

SN1L2_MOUSE
NC score	0.841456 (rank : 108)	θ value	2.86786e-30 (rank : 55)
Query Neighborhood Hits	1931	Target Neighborhood Hits	944	Shared Neighborhood Hits	868
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SN1L2_HUMAN
NC score	0.841316 (rank : 109)	θ value	1.4233e-29 (rank : 63)
Query Neighborhood Hits	1931	Target Neighborhood Hits	964	Shared Neighborhood Hits	876
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

PDPK1_HUMAN
NC score	0.841209 (rank : 110)	θ value	4.58923e-20 (rank : 255)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	836
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

TSSK6_MOUSE
NC score	0.841127 (rank : 111)	θ value	1.42661e-21 (rank : 208)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	821
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PDPK1_MOUSE
NC score	0.840923 (rank : 112)	θ value	3.51386e-20 (rank : 251)
Query Neighborhood Hits	1931	Target Neighborhood Hits	852	Shared Neighborhood Hits	835
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

CHK1_MOUSE
NC score	0.840858 (rank : 113)	θ value	7.58209e-15 (rank : 439)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	831
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

SBK1_MOUSE
NC score	0.840722 (rank : 114)	θ value	2.7842e-17 (rank : 353)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	811
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

MARK2_HUMAN
NC score	0.840621 (rank : 115)	θ value	2.27234e-27 (rank : 89)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1056	Shared Neighborhood Hits	893
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

NEK3_MOUSE
NC score	0.840533 (rank : 116)	θ value	4.73814e-25 (rank : 132)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	840
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

MARK3_MOUSE
NC score	0.840488 (rank : 117)	θ value	1.47289e-26 (rank : 110)
Query Neighborhood Hits	1931	Target Neighborhood Hits	919	Shared Neighborhood Hits	852
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

KPCD3_MOUSE
NC score	0.840449 (rank : 118)	θ value	2.59989e-23 (rank : 168)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	838
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KS6A2_MOUSE
NC score	0.840327 (rank : 119)	θ value	6.59618e-35 (rank : 36)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

MKNK2_HUMAN
NC score	0.840295 (rank : 120)	θ value	3.28125e-26 (rank : 117)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	813
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

TSSK6_HUMAN
NC score	0.840261 (rank : 121)	θ value	4.15078e-21 (rank : 223)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	820
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

KPCD3_HUMAN
NC score	0.840209 (rank : 122)	θ value	7.56453e-23 (rank : 177)
Query Neighborhood Hits	1931	Target Neighborhood Hits	895	Shared Neighborhood Hits	838
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

CHK1_HUMAN
NC score	0.840163 (rank : 123)	θ value	2.88119e-14 (rank : 460)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MARK1_HUMAN
NC score	0.840091 (rank : 124)	θ value	1.85889e-29 (rank : 64)
Query Neighborhood Hits	1931	Target Neighborhood Hits	887	Shared Neighborhood Hits	844
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

TSSK4_HUMAN
NC score	0.840045 (rank : 125)	θ value	3.17815e-21 (rank : 219)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	830
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

MARK2_MOUSE
NC score	0.839921 (rank : 126)	θ value	5.06226e-27 (rank : 97)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1018	Shared Neighborhood Hits	880
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK1_MOUSE
NC score	0.839837 (rank : 127)	θ value	2.27234e-27 (rank : 88)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	844
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

PASK_MOUSE
NC score	0.839709 (rank : 128)	θ value	5.43371e-13 (rank : 527)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	830
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

KS6A2_HUMAN
NC score	0.839595 (rank : 129)	θ value	1.24399e-33 (rank : 38)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	841
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PRKY_HUMAN
NC score	0.839561 (rank : 130)	θ value	5.07402e-19 (rank : 289)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	835
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

TSSK3_HUMAN
NC score	0.839471 (rank : 131)	θ value	1.6852e-22 (rank : 187)
Query Neighborhood Hits	1931	Target Neighborhood Hits	806	Shared Neighborhood Hits	803
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

MKNK2_MOUSE
NC score	0.839441 (rank : 132)	θ value	1.62847e-25 (rank : 123)
Query Neighborhood Hits	1931	Target Neighborhood Hits	819	Shared Neighborhood Hits	811
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

NEK3_HUMAN
NC score	0.839374 (rank : 133)	θ value	2.96777e-27 (rank : 91)
Query Neighborhood Hits	1931	Target Neighborhood Hits	865	Shared Neighborhood Hits	839
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

SBK1_HUMAN
NC score	0.839195 (rank : 134)	θ value	1.80466e-16 (rank : 392)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	811
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

KS6A6_HUMAN
NC score	0.839126 (rank : 135)	θ value	1.98606e-31 (rank : 48)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	840
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

TSSK3_MOUSE
NC score	0.839034 (rank : 136)	θ value	4.9032e-22 (rank : 199)
Query Neighborhood Hits	1931	Target Neighborhood Hits	806	Shared Neighborhood Hits	802
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

KS6A1_MOUSE
NC score	0.838990 (rank : 137)	θ value	2.12192e-33 (rank : 40)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	838
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

TSSK1_MOUSE
NC score	0.838840 (rank : 138)	θ value	8.10077e-17 (rank : 380)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	822
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KS6A3_MOUSE
NC score	0.838752 (rank : 139)	θ value	5.22648e-32 (rank : 47)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	842
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.838750 (rank : 140)	θ value	5.22648e-32 (rank : 46)
Query Neighborhood Hits	1931	Target Neighborhood Hits	859	Shared Neighborhood Hits	842
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A1_HUMAN
NC score	0.838694 (rank : 141)	θ value	4.72714e-33 (rank : 43)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	842
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

TSSK2_HUMAN
NC score	0.837836 (rank : 142)	θ value	1.92812e-18 (rank : 311)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	817
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

KAPCG_HUMAN
NC score	0.836835 (rank : 143)	θ value	1.29031e-22 (rank : 184)
Query Neighborhood Hits	1931	Target Neighborhood Hits	845	Shared Neighborhood Hits	834
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

TSSK1_HUMAN
NC score	0.836776 (rank : 144)	θ value	3.40345e-15 (rank : 432)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	814
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MARK3_HUMAN
NC score	0.836342 (rank : 145)	θ value	4.9032e-22 (rank : 197)
Query Neighborhood Hits	1931	Target Neighborhood Hits	893	Shared Neighborhood Hits	841
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

PASK_HUMAN
NC score	0.835679 (rank : 146)	θ value	1.02475e-11 (rank : 580)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	826
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

MKNK1_MOUSE
NC score	0.835545 (rank : 147)	θ value	3.75424e-22 (rank : 194)
Query Neighborhood Hits	1931	Target Neighborhood Hits	811	Shared Neighborhood Hits	800
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

TSSK2_MOUSE
NC score	0.834813 (rank : 148)	θ value	5.25075e-16 (rank : 412)
Query Neighborhood Hits	1931	Target Neighborhood Hits	819	Shared Neighborhood Hits	809
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

NEK2_HUMAN
NC score	0.834804 (rank : 149)	θ value	3.63628e-17 (rank : 361)
Query Neighborhood Hits	1931	Target Neighborhood Hits	908	Shared Neighborhood Hits	826
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

PRKX_HUMAN
NC score	0.834777 (rank : 150)	θ value	8.36355e-22 (rank : 203)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	835
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

KS6A5_HUMAN
NC score	0.834604 (rank : 151)	θ value	7.56453e-23 (rank : 178)
Query Neighborhood Hits	1931	Target Neighborhood Hits	855	Shared Neighborhood Hits	839
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

PRKX_MOUSE
NC score	0.834527 (rank : 152)	θ value	3.17815e-21 (rank : 218)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	838
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PAK6_HUMAN
NC score	0.834263 (rank : 153)	θ value	5.60996e-18 (rank : 331)
Query Neighborhood Hits	1931	Target Neighborhood Hits	915	Shared Neighborhood Hits	860
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

KAPCA_HUMAN
NC score	0.834078 (rank : 154)	θ value	7.56453e-23 (rank : 176)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	832
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

NEK2_MOUSE
NC score	0.834029 (rank : 155)	θ value	3.40345e-15 (rank : 429)
Query Neighborhood Hits	1931	Target Neighborhood Hits	876	Shared Neighborhood Hits	825
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

KAPCA_MOUSE
NC score	0.833919 (rank : 156)	θ value	4.43474e-23 (rank : 171)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	830
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

CAMKV_MOUSE
NC score	0.833806 (rank : 157)	θ value	1.5242e-23 (rank : 162)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	797
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

KAPCB_HUMAN
NC score	0.833712 (rank : 158)	θ value	6.18819e-25 (rank : 134)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	831
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

PAK2_HUMAN
NC score	0.833608 (rank : 159)	θ value	3.51386e-20 (rank : 249)
Query Neighborhood Hits	1931	Target Neighborhood Hits	862	Shared Neighborhood Hits	845
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
NC score	0.833604 (rank : 160)	θ value	3.51386e-20 (rank : 250)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

KAPCB_MOUSE
NC score	0.833481 (rank : 161)	θ value	6.18819e-25 (rank : 135)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	831
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

PAK4_HUMAN
NC score	0.833384 (rank : 162)	θ value	9.56915e-18 (rank : 337)
Query Neighborhood Hits	1931	Target Neighborhood Hits	924	Shared Neighborhood Hits	872
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

ULK4_MOUSE
NC score	0.833295 (rank : 163)	θ value	9.90251e-15 (rank : 442)
Query Neighborhood Hits	1931	Target Neighborhood Hits	793	Shared Neighborhood Hits	773
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

KS6B2_HUMAN
NC score	0.832958 (rank : 164)	θ value	7.06379e-29 (rank : 70)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	845
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

NEK4_MOUSE
NC score	0.832779 (rank : 165)	θ value	2.13179e-17 (rank : 349)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	844
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

KS6B1_HUMAN
NC score	0.832690 (rank : 166)	θ value	3.87602e-27 (rank : 95)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	834
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

PAK7_MOUSE
NC score	0.832663 (rank : 167)	θ value	1.80466e-16 (rank : 391)
Query Neighborhood Hits	1931	Target Neighborhood Hits	875	Shared Neighborhood Hits	850
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PAK7_HUMAN
NC score	0.832654 (rank : 168)	θ value	1.058e-16 (rank : 383)
Query Neighborhood Hits	1931	Target Neighborhood Hits	875	Shared Neighborhood Hits	850
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

KS6B1_MOUSE
NC score	0.832542 (rank : 169)	θ value	3.87602e-27 (rank : 96)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	833
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

NEK1_HUMAN
NC score	0.832469 (rank : 170)	θ value	1.5773e-20 (rank : 238)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1129	Shared Neighborhood Hits	854
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

KS6A4_MOUSE
NC score	0.832412 (rank : 171)	θ value	2.35151e-24 (rank : 147)
Query Neighborhood Hits	1931	Target Neighborhood Hits	866	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

KS6A4_HUMAN
NC score	0.832276 (rank : 172)	θ value	3.07116e-24 (rank : 152)
Query Neighborhood Hits	1931	Target Neighborhood Hits	868	Shared Neighborhood Hits	842
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

PAK4_MOUSE
NC score	0.832173 (rank : 173)	θ value	1.058e-16 (rank : 382)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1098	Shared Neighborhood Hits	926
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

NEK6_HUMAN
NC score	0.831825 (rank : 174)	θ value	5.99374e-20 (rank : 260)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	841
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.831562 (rank : 175)	θ value	1.02238e-19 (rank : 267)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	841
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

KS6B2_MOUSE
NC score	0.831512 (rank : 176)	θ value	5.40856e-29 (rank : 66)
Query Neighborhood Hits	1931	Target Neighborhood Hits	871	Shared Neighborhood Hits	840
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

NEK4_HUMAN
NC score	0.831282 (rank : 177)	θ value	8.10077e-17 (rank : 378)
Query Neighborhood Hits	1931	Target Neighborhood Hits	883	Shared Neighborhood Hits	836
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

PAK3_MOUSE
NC score	0.831045 (rank : 178)	θ value	2.5182e-18 (rank : 320)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	846
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK3_HUMAN
NC score	0.830776 (rank : 179)	θ value	2.5182e-18 (rank : 319)
Query Neighborhood Hits	1931	Target Neighborhood Hits	887	Shared Neighborhood Hits	849
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK1_HUMAN
NC score	0.830735 (rank : 180)	θ value	5.60996e-18 (rank : 330)
Query Neighborhood Hits	1931	Target Neighborhood Hits	873	Shared Neighborhood Hits	845
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

NEK1_MOUSE
NC score	0.830734 (rank : 181)	θ value	9.87957e-23 (rank : 181)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1311	Shared Neighborhood Hits	882
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

CAMKV_HUMAN
NC score	0.830729 (rank : 182)	θ value	1.5242e-23 (rank : 161)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1084	Shared Neighborhood Hits	866
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

ST32A_MOUSE
NC score	0.830597 (rank : 183)	θ value	1.16975e-15 (rank : 419)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

M3K1_MOUSE
NC score	0.830361 (rank : 184)	θ value	9.56915e-18 (rank : 334)
Query Neighborhood Hits	1931	Target Neighborhood Hits	952	Shared Neighborhood Hits	857
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

PAK1_MOUSE
NC score	0.830344 (rank : 185)	θ value	2.5182e-18 (rank : 318)
Query Neighborhood Hits	1931	Target Neighborhood Hits	878	Shared Neighborhood Hits	847
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

ST32A_HUMAN
NC score	0.830217 (rank : 186)	θ value	5.25075e-16 (rank : 411)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	824
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

AKT3_HUMAN
NC score	0.829854 (rank : 187)	θ value	2.77775e-25 (rank : 125)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.829846 (rank : 188)	θ value	2.77775e-25 (rank : 126)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	834
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

NEK11_MOUSE
NC score	0.829349 (rank : 189)	θ value	2.20094e-22 (rank : 189)
Query Neighborhood Hits	1931	Target Neighborhood Hits	875	Shared Neighborhood Hits	836
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

M3K2_MOUSE
NC score	0.829250 (rank : 190)	θ value	9.56915e-18 (rank : 335)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	832
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

SGK1_HUMAN
NC score	0.829199 (rank : 191)	θ value	2.5182e-18 (rank : 321)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	834
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

M3K3_MOUSE
NC score	0.829170 (rank : 192)	θ value	1.24977e-17 (rank : 341)
Query Neighborhood Hits	1931	Target Neighborhood Hits	876	Shared Neighborhood Hits	841
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK7_MOUSE
NC score	0.829155 (rank : 193)	θ value	1.5773e-20 (rank : 239)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	842
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

ST32B_MOUSE
NC score	0.829122 (rank : 194)	θ value	6.62687e-19 (rank : 292)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	820
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

NEK7_HUMAN
NC score	0.829048 (rank : 195)	θ value	3.51386e-20 (rank : 248)
Query Neighborhood Hits	1931	Target Neighborhood Hits	846	Shared Neighborhood Hits	841
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

M3K3_HUMAN
NC score	0.828952 (rank : 196)	θ value	2.5182e-18 (rank : 315)
Query Neighborhood Hits	1931	Target Neighborhood Hits	885	Shared Neighborhood Hits	843
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

SGK1_MOUSE
NC score	0.828836 (rank : 197)	θ value	4.29542e-18 (rank : 327)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	834
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

AKT2_HUMAN
NC score	0.828566 (rank : 198)	θ value	2.20094e-22 (rank : 188)
Query Neighborhood Hits	1931	Target Neighborhood Hits	878	Shared Neighborhood Hits	829
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

ST32B_HUMAN
NC score	0.828534 (rank : 199)	θ value	3.28887e-18 (rank : 325)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

SGK2_HUMAN
NC score	0.828352 (rank : 200)	θ value	4.74913e-17 (rank : 369)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	830
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK2_MOUSE
NC score	0.828292 (rank : 201)	θ value	1.33526e-19 (rank : 274)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	827
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

KS6A5_MOUSE
NC score	0.828065 (rank : 202)	θ value	5.99374e-20 (rank : 259)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	837
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

M3K2_HUMAN
NC score	0.828044 (rank : 203)	θ value	6.20254e-17 (rank : 372)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	836
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

AKT2_MOUSE
NC score	0.827927 (rank : 204)	θ value	8.36355e-22 (rank : 200)
Query Neighborhood Hits	1931	Target Neighborhood Hits	875	Shared Neighborhood Hits	829
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

ST32C_MOUSE
NC score	0.827478 (rank : 205)	θ value	3.76295e-14 (rank : 470)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	815
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

MAPK5_MOUSE
NC score	0.826976 (rank : 206)	θ value	2.5182e-18 (rank : 316)
Query Neighborhood Hits	1931	Target Neighborhood Hits	799	Shared Neighborhood Hits	789
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

NEK11_HUMAN
NC score	0.826442 (rank : 207)	θ value	1.02238e-19 (rank : 266)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1043	Shared Neighborhood Hits	857
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PIM2_MOUSE
NC score	0.826353 (rank : 208)	θ value	5.25075e-16 (rank : 409)
Query Neighborhood Hits	1931	Target Neighborhood Hits	809	Shared Neighborhood Hits	800
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PIM2_HUMAN
NC score	0.826096 (rank : 209)	θ value	4.74913e-17 (rank : 367)
Query Neighborhood Hits	1931	Target Neighborhood Hits	808	Shared Neighborhood Hits	803
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

M3K4_HUMAN
NC score	0.826086 (rank : 210)	θ value	4.44505e-15 (rank : 435)
Query Neighborhood Hits	1931	Target Neighborhood Hits	911	Shared Neighborhood Hits	850
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

ST32C_HUMAN
NC score	0.825891 (rank : 211)	θ value	3.76295e-14 (rank : 469)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	820
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

M3K6_HUMAN
NC score	0.825863 (rank : 212)	θ value	3.63628e-17 (rank : 359)
Query Neighborhood Hits	1931	Target Neighborhood Hits	889	Shared Neighborhood Hits	847
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

IKKA_MOUSE
NC score	0.825841 (rank : 213)	θ value	8.10077e-17 (rank : 374)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	835
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MAPK5_HUMAN
NC score	0.825700 (rank : 214)	θ value	1.92812e-18 (rank : 305)
Query Neighborhood Hits	1931	Target Neighborhood Hits	795	Shared Neighborhood Hits	784
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

AKT1_HUMAN
NC score	0.825500 (rank : 215)	θ value	2.69047e-20 (rank : 241)
Query Neighborhood Hits	1931	Target Neighborhood Hits	885	Shared Neighborhood Hits	830
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
NC score	0.825173 (rank : 216)	θ value	2.69047e-20 (rank : 242)
Query Neighborhood Hits	1931	Target Neighborhood Hits	878	Shared Neighborhood Hits	829
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

NEK8_MOUSE
NC score	0.824948 (rank : 217)	θ value	9.87957e-23 (rank : 183)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	836
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK8_HUMAN
NC score	0.824822 (rank : 218)	θ value	9.87957e-23 (rank : 182)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	836
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

M3K4_MOUSE
NC score	0.824771 (rank : 219)	θ value	2.20605e-14 (rank : 456)
Query Neighborhood Hits	1931	Target Neighborhood Hits	924	Shared Neighborhood Hits	848
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

KGP2_HUMAN
NC score	0.824301 (rank : 220)	θ value	6.84181e-24 (rank : 157)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1023	Shared Neighborhood Hits	845
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
NC score	0.823985 (rank : 221)	θ value	1.99067e-23 (rank : 164)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1029	Shared Neighborhood Hits	841
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

RK_MOUSE
NC score	0.823964 (rank : 222)	θ value	1.16975e-15 (rank : 418)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	819
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

YSK4_HUMAN
NC score	0.823672 (rank : 223)	θ value	2.20094e-22 (rank : 191)
Query Neighborhood Hits	1931	Target Neighborhood Hits	921	Shared Neighborhood Hits	841
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

IKKA_HUMAN
NC score	0.823532 (rank : 224)	θ value	4.02038e-16 (rank : 399)
Query Neighborhood Hits	1931	Target Neighborhood Hits	863	Shared Neighborhood Hits	833
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MAST3_HUMAN
NC score	0.823505 (rank : 225)	θ value	1.12775e-26 (rank : 104)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1128	Shared Neighborhood Hits	896
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

IKKE_HUMAN
NC score	0.823444 (rank : 226)	θ value	1.52774e-15 (rank : 421)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	810
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

SGK3_MOUSE
NC score	0.823174 (rank : 227)	θ value	2.27762e-19 (rank : 276)
Query Neighborhood Hits	1931	Target Neighborhood Hits	882	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

M3K5_MOUSE
NC score	0.823085 (rank : 228)	θ value	2.20605e-14 (rank : 457)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	833
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_HUMAN
NC score	0.823083 (rank : 229)	θ value	2.88119e-14 (rank : 462)
Query Neighborhood Hits	1931	Target Neighborhood Hits	868	Shared Neighborhood Hits	833
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

SGK3_HUMAN
NC score	0.823029 (rank : 230)	θ value	3.88503e-19 (rank : 285)
Query Neighborhood Hits	1931	Target Neighborhood Hits	877	Shared Neighborhood Hits	826
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

M3K15_HUMAN
NC score	0.822562 (rank : 231)	θ value	1.80466e-16 (rank : 389)
Query Neighborhood Hits	1931	Target Neighborhood Hits	914	Shared Neighborhood Hits	840
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

IKKB_HUMAN
NC score	0.822477 (rank : 232)	θ value	3.07829e-16 (rank : 396)
Query Neighborhood Hits	1931	Target Neighborhood Hits	980	Shared Neighborhood Hits	837
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KGP1A_HUMAN
NC score	0.822423 (rank : 233)	θ value	5.07402e-19 (rank : 286)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	835
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

PIM1_MOUSE
NC score	0.822303 (rank : 234)	θ value	2.88119e-14 (rank : 464)
Query Neighborhood Hits	1931	Target Neighborhood Hits	787	Shared Neighborhood Hits	781
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_HUMAN
NC score	0.822283 (rank : 235)	θ value	2.43908e-13 (rank : 511)
Query Neighborhood Hits	1931	Target Neighborhood Hits	797	Shared Neighborhood Hits	793
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

STK3_MOUSE
NC score	0.822209 (rank : 236)	θ value	2.20094e-22 (rank : 190)
Query Neighborhood Hits	1931	Target Neighborhood Hits	869	Shared Neighborhood Hits	835
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

KGP1B_MOUSE
NC score	0.822070 (rank : 237)	θ value	5.07402e-19 (rank : 288)
Query Neighborhood Hits	1931	Target Neighborhood Hits	922	Shared Neighborhood Hits	838
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

RK_HUMAN
NC score	0.822024 (rank : 238)	θ value	3.07829e-16 (rank : 398)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	822
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KGP1B_HUMAN
NC score	0.822011 (rank : 239)	θ value	5.07402e-19 (rank : 287)
Query Neighborhood Hits	1931	Target Neighborhood Hits	921	Shared Neighborhood Hits	838
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

IKKB_MOUSE
NC score	0.821996 (rank : 240)	θ value	8.95645e-16 (rank : 414)
Query Neighborhood Hits	1931	Target Neighborhood Hits	984	Shared Neighborhood Hits	835
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

STK3_HUMAN
NC score	0.821930 (rank : 241)	θ value	2.43343e-21 (rank : 214)
Query Neighborhood Hits	1931	Target Neighborhood Hits	861	Shared Neighborhood Hits	838
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK4_MOUSE
NC score	0.821541 (rank : 242)	θ value	8.36355e-22 (rank : 204)
Query Neighborhood Hits	1931	Target Neighborhood Hits	873	Shared Neighborhood Hits	835
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK4_HUMAN
NC score	0.821502 (rank : 243)	θ value	1.86321e-21 (rank : 210)
Query Neighborhood Hits	1931	Target Neighborhood Hits	870	Shared Neighborhood Hits	835
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

PIM3_HUMAN
NC score	0.821480 (rank : 244)	θ value	1.74796e-11 (rank : 594)
Query Neighborhood Hits	1931	Target Neighborhood Hits	789	Shared Neighborhood Hits	787
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

TBK1_HUMAN
NC score	0.821430 (rank : 245)	θ value	1.68911e-14 (rank : 450)
Query Neighborhood Hits	1931	Target Neighborhood Hits	861	Shared Neighborhood Hits	800
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

E2AK2_MOUSE
NC score	0.821423 (rank : 246)	θ value	2.52405e-10 (rank : 634)
Query Neighborhood Hits	1931	Target Neighborhood Hits	864	Shared Neighborhood Hits	836
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

MAST2_MOUSE
NC score	0.821124 (rank : 247)	θ value	9.54697e-26 (rank : 119)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1110	Shared Neighborhood Hits	884
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

TBK1_MOUSE
NC score	0.821096 (rank : 248)	θ value	1.29331e-14 (rank : 445)
Query Neighborhood Hits	1931	Target Neighborhood Hits	893	Shared Neighborhood Hits	803
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

IKKE_MOUSE
NC score	0.821060 (rank : 249)	θ value	7.58209e-15 (rank : 440)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	815
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

OXSR1_HUMAN
NC score	0.820819 (rank : 250)	θ value	1.5773e-20 (rank : 240)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	843
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PKN3_HUMAN
NC score	0.820770 (rank : 251)	θ value	1.6852e-22 (rank : 185)
Query Neighborhood Hits	1931	Target Neighborhood Hits	893	Shared Neighborhood Hits	839
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

OXSR1_MOUSE
NC score	0.820545 (rank : 252)	θ value	4.58923e-20 (rank : 254)
Query Neighborhood Hits	1931	Target Neighborhood Hits	865	Shared Neighborhood Hits	840
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PKN2_MOUSE
NC score	0.820183 (rank : 253)	θ value	8.10077e-17 (rank : 379)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	830
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_HUMAN
NC score	0.819937 (rank : 254)	θ value	4.74913e-17 (rank : 368)
Query Neighborhood Hits	1931	Target Neighborhood Hits	892	Shared Neighborhood Hits	828
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

TTK_HUMAN
NC score	0.819904 (rank : 255)	θ value	6.62687e-19 (rank : 293)
Query Neighborhood Hits	1931	Target Neighborhood Hits	816	Shared Neighborhood Hits	775
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

MAST2_HUMAN
NC score	0.819775 (rank : 256)	θ value	2.77775e-25 (rank : 127)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1189	Shared Neighborhood Hits	910
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

KPCT_MOUSE
NC score	0.819626 (rank : 257)	θ value	3.63628e-17 (rank : 357)
Query Neighborhood Hits	1931	Target Neighborhood Hits	895	Shared Neighborhood Hits	840
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

M3K8_HUMAN
NC score	0.819534 (rank : 258)	θ value	1.52774e-15 (rank : 422)
Query Neighborhood Hits	1931	Target Neighborhood Hits	807	Shared Neighborhood Hits	800
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

STK39_MOUSE
NC score	0.819328 (rank : 259)	θ value	1.92812e-18 (rank : 309)
Query Neighborhood Hits	1931	Target Neighborhood Hits	915	Shared Neighborhood Hits	852
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

PIM3_MOUSE
NC score	0.819308 (rank : 260)	θ value	3.89403e-11 (rank : 606)
Query Neighborhood Hits	1931	Target Neighborhood Hits	783	Shared Neighborhood Hits	781
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

KPCT_HUMAN
NC score	0.819252 (rank : 261)	θ value	1.42992e-13 (rank : 493)
Query Neighborhood Hits	1931	Target Neighborhood Hits	897	Shared Neighborhood Hits	843
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

STK39_HUMAN
NC score	0.819195 (rank : 262)	θ value	1.92812e-18 (rank : 308)
Query Neighborhood Hits	1931	Target Neighborhood Hits	882	Shared Neighborhood Hits	845
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

M3K14_HUMAN
NC score	0.819163 (rank : 263)	θ value	3.18553e-13 (rank : 513)
Query Neighborhood Hits	1931	Target Neighborhood Hits	887	Shared Neighborhood Hits	837
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

KPCI_MOUSE
NC score	0.819058 (rank : 264)	θ value	4.74913e-17 (rank : 364)
Query Neighborhood Hits	1931	Target Neighborhood Hits	888	Shared Neighborhood Hits	845
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

CDKL3_MOUSE
NC score	0.819051 (rank : 265)	θ value	3.63628e-17 (rank : 355)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	831
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

STK24_HUMAN
NC score	0.819042 (rank : 266)	θ value	2.69047e-20 (rank : 244)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

KPCI_HUMAN
NC score	0.818957 (rank : 267)	θ value	4.74913e-17 (rank : 363)
Query Neighborhood Hits	1931	Target Neighborhood Hits	885	Shared Neighborhood Hits	845
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

PKN3_MOUSE
NC score	0.818916 (rank : 268)	θ value	1.02238e-19 (rank : 268)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	866
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

M3K8_MOUSE
NC score	0.818902 (rank : 269)	θ value	8.95645e-16 (rank : 415)
Query Neighborhood Hits	1931	Target Neighborhood Hits	815	Shared Neighborhood Hits	801
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

TTK_MOUSE
NC score	0.818518 (rank : 270)	θ value	4.29542e-18 (rank : 328)
Query Neighborhood Hits	1931	Target Neighborhood Hits	803	Shared Neighborhood Hits	759
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

PKN1_MOUSE
NC score	0.818476 (rank : 271)	θ value	2.35696e-16 (rank : 393)
Query Neighborhood Hits	1931	Target Neighborhood Hits	888	Shared Neighborhood Hits	832
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

STK24_MOUSE
NC score	0.818468 (rank : 272)	θ value	5.99374e-20 (rank : 262)
Query Neighborhood Hits	1931	Target Neighborhood Hits	856	Shared Neighborhood Hits	844
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

MAST1_HUMAN
NC score	0.818326 (rank : 273)	θ value	6.18819e-25 (rank : 136)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1146	Shared Neighborhood Hits	907
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
NC score	0.818289 (rank : 274)	θ value	1.24688e-25 (rank : 120)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1123	Shared Neighborhood Hits	900
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

CDKL3_HUMAN
NC score	0.818225 (rank : 275)	θ value	6.85773e-16 (rank : 413)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	831
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

PKN1_HUMAN
NC score	0.818180 (rank : 276)	θ value	5.25075e-16 (rank : 410)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	839
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

MST4_MOUSE
NC score	0.817392 (rank : 277)	θ value	3.88503e-19 (rank : 284)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	838
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.817370 (rank : 278)	θ value	2.97466e-19 (rank : 279)
Query Neighborhood Hits	1931	Target Neighborhood Hits	852	Shared Neighborhood Hits	838
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

STK25_HUMAN
NC score	0.816854 (rank : 279)	θ value	1.47631e-18 (rank : 302)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	838
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

M3K14_MOUSE
NC score	0.816806 (rank : 280)	θ value	4.59992e-12 (rank : 565)
Query Neighborhood Hits	1931	Target Neighborhood Hits	889	Shared Neighborhood Hits	834
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

KPCL_MOUSE
NC score	0.816538 (rank : 281)	θ value	1.09232e-21 (rank : 205)
Query Neighborhood Hits	1931	Target Neighborhood Hits	891	Shared Neighborhood Hits	828
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

STK25_MOUSE
NC score	0.816440 (rank : 282)	θ value	5.07402e-19 (rank : 290)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	837
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

PDK1L_HUMAN
NC score	0.816115 (rank : 283)	θ value	3.64472e-09 (rank : 687)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	811
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

GRK6_HUMAN
NC score	0.816024 (rank : 284)	θ value	2.88119e-14 (rank : 461)
Query Neighborhood Hits	1931	Target Neighborhood Hits	823	Shared Neighborhood Hits	819
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

CDKL1_MOUSE
NC score	0.815955 (rank : 285)	θ value	3.88503e-19 (rank : 281)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	821
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

MP2K2_HUMAN
NC score	0.815953 (rank : 286)	θ value	1.52774e-15 (rank : 424)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PDK1L_MOUSE
NC score	0.815930 (rank : 287)	θ value	6.21693e-09 (rank : 703)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	812
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

CDKL1_HUMAN
NC score	0.815582 (rank : 288)	θ value	3.51386e-20 (rank : 246)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	824
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL4_MOUSE
NC score	0.815467 (rank : 289)	θ value	1.2077e-20 (rank : 232)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

MP2K1_HUMAN
NC score	0.815273 (rank : 290)	θ value	8.10077e-17 (rank : 375)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	821
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

GRK6_MOUSE
NC score	0.815186 (rank : 291)	θ value	4.91457e-14 (rank : 472)
Query Neighborhood Hits	1931	Target Neighborhood Hits	820	Shared Neighborhood Hits	818
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MP2K1_MOUSE
NC score	0.815164 (rank : 292)	θ value	8.10077e-17 (rank : 376)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	821
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

GRK5_MOUSE
NC score	0.815074 (rank : 293)	θ value	5.25075e-16 (rank : 405)
Query Neighborhood Hits	1931	Target Neighborhood Hits	823	Shared Neighborhood Hits	811
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KPCE_MOUSE
NC score	0.814899 (rank : 294)	θ value	2.43343e-21 (rank : 211)
Query Neighborhood Hits	1931	Target Neighborhood Hits	906	Shared Neighborhood Hits	834
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCL_HUMAN
NC score	0.814862 (rank : 295)	θ value	1.02238e-19 (rank : 265)
Query Neighborhood Hits	1931	Target Neighborhood Hits	887	Shared Neighborhood Hits	828
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCE_HUMAN
NC score	0.814813 (rank : 296)	θ value	8.36355e-22 (rank : 202)
Query Neighborhood Hits	1931	Target Neighborhood Hits	906	Shared Neighborhood Hits	833
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

GRK5_HUMAN
NC score	0.814794 (rank : 297)	θ value	1.38178e-16 (rank : 386)
Query Neighborhood Hits	1931	Target Neighborhood Hits	819	Shared Neighborhood Hits	811
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

CDKL5_HUMAN
NC score	0.814664 (rank : 298)	θ value	1.13037e-18 (rank : 297)
Query Neighborhood Hits	1931	Target Neighborhood Hits	967	Shared Neighborhood Hits	847
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

KPCD_HUMAN
NC score	0.814650 (rank : 299)	θ value	1.47631e-18 (rank : 301)
Query Neighborhood Hits	1931	Target Neighborhood Hits	900	Shared Neighborhood Hits	842
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCZ_MOUSE
NC score	0.814460 (rank : 300)	θ value	4.02038e-16 (rank : 401)
Query Neighborhood Hits	1931	Target Neighborhood Hits	882	Shared Neighborhood Hits	836
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.814426 (rank : 301)	θ value	4.02038e-16 (rank : 400)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	837
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MP2K2_MOUSE
NC score	0.814175 (rank : 302)	θ value	1.29331e-14 (rank : 444)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	824
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

KPCD_MOUSE
NC score	0.814105 (rank : 303)	θ value	6.62687e-19 (rank : 291)
Query Neighborhood Hits	1931	Target Neighborhood Hits	888	Shared Neighborhood Hits	839
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

M4K3_HUMAN
NC score	0.813627 (rank : 304)	θ value	1.2077e-20 (rank : 234)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MAST4_HUMAN
NC score	0.813609 (rank : 305)	θ value	1.37858e-24 (rank : 141)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1804	Shared Neighborhood Hits	1063
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PMYT1_MOUSE
NC score	0.813306 (rank : 306)	θ value	2.60593e-15 (rank : 428)
Query Neighborhood Hits	1931	Target Neighborhood Hits	910	Shared Neighborhood Hits	853
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

MP2K5_MOUSE
NC score	0.813046 (rank : 307)	θ value	3.18553e-13 (rank : 515)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

NEK9_HUMAN
NC score	0.813001 (rank : 308)	θ value	9.56915e-18 (rank : 336)
Query Neighborhood Hits	1931	Target Neighborhood Hits	900	Shared Neighborhood Hits	841
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

CDKL2_MOUSE
NC score	0.812804 (rank : 309)	θ value	2.7842e-17 (rank : 351)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	828
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CDKL4_HUMAN
NC score	0.812755 (rank : 310)	θ value	1.5773e-20 (rank : 236)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	820
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

STK35_HUMAN
NC score	0.812437 (rank : 311)	θ value	1.63604e-09 (rank : 670)
Query Neighborhood Hits	1931	Target Neighborhood Hits	825	Shared Neighborhood Hits	813
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

M4K2_MOUSE
NC score	0.812434 (rank : 312)	θ value	5.42112e-21 (rank : 228)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

ST38L_HUMAN
NC score	0.812375 (rank : 313)	θ value	2.12685e-25 (rank : 124)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	794
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

NEK9_MOUSE
NC score	0.812325 (rank : 314)	θ value	1.80466e-16 (rank : 390)
Query Neighborhood Hits	1931	Target Neighborhood Hits	890	Shared Neighborhood Hits	842
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

GRK7_HUMAN
NC score	0.812214 (rank : 315)	θ value	4.59992e-12 (rank : 564)
Query Neighborhood Hits	1931	Target Neighborhood Hits	820	Shared Neighborhood Hits	813
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

MASTL_HUMAN
NC score	0.812147 (rank : 316)	θ value	2.28291e-11 (rank : 597)
Query Neighborhood Hits	1931	Target Neighborhood Hits	894	Shared Neighborhood Hits	834
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

CDKL2_HUMAN
NC score	0.812146 (rank : 317)	θ value	6.20254e-17 (rank : 370)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	825
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

M4K2_HUMAN
NC score	0.812104 (rank : 318)	θ value	5.42112e-21 (rank : 227)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	831
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

STK38_HUMAN
NC score	0.811645 (rank : 319)	θ value	2.35151e-24 (rank : 150)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	802
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

GRK4_HUMAN
NC score	0.811611 (rank : 320)	θ value	5.43371e-13 (rank : 523)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	812
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

MASTL_MOUSE
NC score	0.811573 (rank : 321)	θ value	2.28291e-11 (rank : 598)
Query Neighborhood Hits	1931	Target Neighborhood Hits	862	Shared Neighborhood Hits	830
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

STK38_MOUSE
NC score	0.811226 (rank : 322)	θ value	1.99067e-23 (rank : 167)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	801
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

E2AK2_HUMAN
NC score	0.810921 (rank : 323)	θ value	1.99992e-07 (rank : 774)
Query Neighborhood Hits	1931	Target Neighborhood Hits	856	Shared Neighborhood Hits	825
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

M4K1_HUMAN
NC score	0.810725 (rank : 324)	θ value	2.13179e-17 (rank : 348)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	840
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
NC score	0.809932 (rank : 325)	θ value	2.7842e-17 (rank : 352)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	837
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

MP2K7_HUMAN
NC score	0.809572 (rank : 326)	θ value	7.84624e-12 (rank : 573)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	822
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

GRK4_MOUSE
NC score	0.809026 (rank : 327)	θ value	2.20605e-14 (rank : 454)
Query Neighborhood Hits	1931	Target Neighborhood Hits	808	Shared Neighborhood Hits	804
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

MP2K5_HUMAN
NC score	0.808928 (rank : 328)	θ value	1.42992e-13 (rank : 498)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	825
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PMYT1_HUMAN
NC score	0.808080 (rank : 329)	θ value	2.0648e-12 (rank : 549)
Query Neighborhood Hits	1931	Target Neighborhood Hits	814	Shared Neighborhood Hits	803
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

TLK1_HUMAN
NC score	0.808029 (rank : 330)	θ value	3.40345e-15 (rank : 430)
Query Neighborhood Hits	1931	Target Neighborhood Hits	967	Shared Neighborhood Hits	783
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
NC score	0.807875 (rank : 331)	θ value	3.40345e-15 (rank : 431)
Query Neighborhood Hits	1931	Target Neighborhood Hits	947	Shared Neighborhood Hits	779
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

CDC2_HUMAN
NC score	0.807267 (rank : 332)	θ value	1.24977e-17 (rank : 339)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	831
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

TLK2_HUMAN
NC score	0.806735 (rank : 333)	θ value	1.29331e-14 (rank : 446)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1044	Shared Neighborhood Hits	804
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

CSKP_MOUSE
NC score	0.806732 (rank : 334)	θ value	2.42779e-29 (rank : 65)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1027	Shared Neighborhood Hits	834
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

ST38L_MOUSE
NC score	0.806652 (rank : 335)	θ value	8.08199e-25 (rank : 140)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	788
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ARBK2_HUMAN
NC score	0.806564 (rank : 336)	θ value	5.43371e-13 (rank : 521)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	817
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ARBK1_HUMAN
NC score	0.806538 (rank : 337)	θ value	4.91457e-14 (rank : 471)
Query Neighborhood Hits	1931	Target Neighborhood Hits	859	Shared Neighborhood Hits	818
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

CDC2_MOUSE
NC score	0.806538 (rank : 338)	θ value	2.7842e-17 (rank : 350)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	830
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

M4K5_MOUSE
NC score	0.806458 (rank : 339)	θ value	4.74913e-17 (rank : 365)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	824
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

ARBK1_MOUSE
NC score	0.805729 (rank : 340)	θ value	1.86753e-13 (rank : 499)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	816
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

CDK3_MOUSE
NC score	0.805567 (rank : 341)	θ value	5.43371e-13 (rank : 522)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	820
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

M4K5_HUMAN
NC score	0.805217 (rank : 342)	θ value	3.63628e-17 (rank : 360)
Query Neighborhood Hits	1931	Target Neighborhood Hits	845	Shared Neighborhood Hits	828
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

DMPK_MOUSE
NC score	0.804981 (rank : 343)	θ value	1.74391e-19 (rank : 275)
Query Neighborhood Hits	1931	Target Neighborhood Hits	908	Shared Neighborhood Hits	824
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

F5006_MOUSE
NC score	0.804899 (rank : 344)	θ value	4.76016e-09 (rank : 696)
Query Neighborhood Hits	1931	Target Neighborhood Hits	793	Shared Neighborhood Hits	790
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

CSKP_HUMAN
NC score	0.804450 (rank : 345)	θ value	7.06379e-29 (rank : 68)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1022	Shared Neighborhood Hits	831
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

TLK2_MOUSE
NC score	0.804400 (rank : 346)	θ value	1.29331e-14 (rank : 447)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1088	Shared Neighborhood Hits	807
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

DMPK_HUMAN
NC score	0.804375 (rank : 347)	θ value	3.63628e-17 (rank : 356)
Query Neighborhood Hits	1931	Target Neighborhood Hits	944	Shared Neighborhood Hits	828
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

CDK3_HUMAN
NC score	0.804110 (rank : 348)	θ value	1.63225e-17 (rank : 343)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	829
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

MP2K4_HUMAN
NC score	0.803402 (rank : 349)	θ value	1.33837e-11 (rank : 589)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	826
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
NC score	0.803397 (rank : 350)	θ value	1.33837e-11 (rank : 590)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	826
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

CDK2_HUMAN
NC score	0.803015 (rank : 351)	θ value	3.51386e-20 (rank : 245)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

ICK_MOUSE
NC score	0.802679 (rank : 352)	θ value	2.20605e-14 (rank : 455)
Query Neighborhood Hits	1931	Target Neighborhood Hits	860	Shared Neighborhood Hits	834
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MAK_MOUSE
NC score	0.801998 (rank : 353)	θ value	1.52774e-15 (rank : 423)
Query Neighborhood Hits	1931	Target Neighborhood Hits	873	Shared Neighborhood Hits	837
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

ICK_HUMAN
NC score	0.801950 (rank : 354)	θ value	1.68911e-14 (rank : 448)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	834
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

MP2K3_MOUSE
NC score	0.801541 (rank : 355)	θ value	4.91457e-14 (rank : 478)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

CDK7_MOUSE
NC score	0.801472 (rank : 356)	θ value	3.28887e-18 (rank : 323)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	821
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK7_HUMAN
NC score	0.801309 (rank : 357)	θ value	3.28887e-18 (rank : 322)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	821
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

F5006_HUMAN
NC score	0.801147 (rank : 358)	θ value	5.62301e-10 (rank : 648)
Query Neighborhood Hits	1931	Target Neighborhood Hits	794	Shared Neighborhood Hits	786
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

MK15_HUMAN
NC score	0.800442 (rank : 359)	θ value	7.09661e-13 (rank : 531)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1038	Shared Neighborhood Hits	902
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MAK_HUMAN
NC score	0.800423 (rank : 360)	θ value	2.43908e-13 (rank : 510)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	830
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

CDK2_MOUSE
NC score	0.800121 (rank : 361)	θ value	3.63628e-17 (rank : 354)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	820
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

MP2K3_HUMAN
NC score	0.799818 (rank : 362)	θ value	1.42992e-13 (rank : 497)
Query Neighborhood Hits	1931	Target Neighborhood Hits	825	Shared Neighborhood Hits	819
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

KPCA_MOUSE
NC score	0.799455 (rank : 363)	θ value	1.2077e-20 (rank : 233)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1067	Shared Neighborhood Hits	847
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

PFTK1_MOUSE
NC score	0.799053 (rank : 364)	θ value	1.99529e-15 (rank : 426)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	822
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_HUMAN
NC score	0.798779 (rank : 365)	θ value	1.16975e-15 (rank : 417)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	822
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KPCA_HUMAN
NC score	0.798571 (rank : 366)	θ value	1.5773e-20 (rank : 237)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1070	Shared Neighborhood Hits	851
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

CDK6_MOUSE
NC score	0.798228 (rank : 367)	θ value	1.38178e-16 (rank : 384)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	828
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

MP2K6_MOUSE
NC score	0.798220 (rank : 368)	θ value	3.76295e-14 (rank : 468)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	823
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

NRK_HUMAN
NC score	0.798039 (rank : 369)	θ value	5.43371e-13 (rank : 526)
Query Neighborhood Hits	1931	Target Neighborhood Hits	931	Shared Neighborhood Hits	838
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

CDK6_HUMAN
NC score	0.797871 (rank : 370)	θ value	4.74913e-17 (rank : 362)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	828
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

MKNK1_HUMAN
NC score	0.797650 (rank : 371)	θ value	6.20254e-17 (rank : 373)
Query Neighborhood Hits	1931	Target Neighborhood Hits	701	Shared Neighborhood Hits	690
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MK15_MOUSE
NC score	0.797646 (rank : 372)	θ value	1.9326e-10 (rank : 629)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	825
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MP2K6_HUMAN
NC score	0.797163 (rank : 373)	θ value	1.09485e-13 (rank : 490)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

NRK_MOUSE
NC score	0.797110 (rank : 374)	θ value	1.58096e-12 (rank : 546)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	839
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

PCTK3_MOUSE
NC score	0.796990 (rank : 375)	θ value	9.26847e-13 (rank : 540)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	820
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

GSK3A_HUMAN
NC score	0.796967 (rank : 376)	θ value	1.42992e-13 (rank : 492)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	810
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

STK40_HUMAN
NC score	0.796557 (rank : 377)	θ value	3.64472e-09 (rank : 688)
Query Neighborhood Hits	1931	Target Neighborhood Hits	751	Shared Neighborhood Hits	746
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

E2AK1_MOUSE
NC score	0.796477 (rank : 378)	θ value	1.09485e-13 (rank : 488)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	812
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CDK5_HUMAN
NC score	0.796464 (rank : 379)	θ value	9.26847e-13 (rank : 537)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

STK40_MOUSE
NC score	0.796304 (rank : 380)	θ value	3.64472e-09 (rank : 689)
Query Neighborhood Hits	1931	Target Neighborhood Hits	751	Shared Neighborhood Hits	745
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

CDK5_MOUSE
NC score	0.796268 (rank : 381)	θ value	2.0648e-12 (rank : 547)
Query Neighborhood Hits	1931	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CCRK_HUMAN
NC score	0.796101 (rank : 382)	θ value	4.16044e-13 (rank : 516)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	824
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

PCTK1_HUMAN
NC score	0.795927 (rank : 383)	θ value	2.20605e-14 (rank : 459)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
NC score	0.795701 (rank : 384)	θ value	4.91457e-14 (rank : 479)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	821
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

CCRK_MOUSE
NC score	0.795260 (rank : 385)	θ value	1.09485e-13 (rank : 487)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

STK16_HUMAN
NC score	0.795091 (rank : 386)	θ value	9.29e-05 (rank : 933)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	822
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

TAOK2_HUMAN
NC score	0.795086 (rank : 387)	θ value	3.51386e-20 (rank : 252)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1172	Shared Neighborhood Hits	861
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

MK12_MOUSE
NC score	0.795081 (rank : 388)	θ value	3.07829e-16 (rank : 397)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PCTK3_HUMAN
NC score	0.794566 (rank : 389)	θ value	7.09661e-13 (rank : 534)
Query Neighborhood Hits	1931	Target Neighborhood Hits	827	Shared Neighborhood Hits	815
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

SLK_MOUSE
NC score	0.794408 (rank : 390)	θ value	1.73987e-27 (rank : 87)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1798	Shared Neighborhood Hits	893
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

STK16_MOUSE
NC score	0.794323 (rank : 391)	θ value	0.00020696 (rank : 948)
Query Neighborhood Hits	1931	Target Neighborhood Hits	824	Shared Neighborhood Hits	820
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

MK12_HUMAN
NC score	0.793746 (rank : 392)	θ value	2.88119e-14 (rank : 463)
Query Neighborhood Hits	1931	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

GSK3B_HUMAN
NC score	0.793592 (rank : 393)	θ value	3.52202e-12 (rank : 555)
Query Neighborhood Hits	1931	Target Neighborhood Hits	801	Shared Neighborhood Hits	795
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.793574 (rank : 394)	θ value	3.52202e-12 (rank : 556)
Query Neighborhood Hits	1931	Target Neighborhood Hits	800	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

SLK_HUMAN
NC score	0.793453 (rank : 395)	θ value	1.33217e-27 (rank : 86)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1775	Shared Neighborhood Hits	890
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

ERN1_HUMAN
NC score	0.793178 (rank : 396)	θ value	1.74796e-11 (rank : 592)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	813
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

LATS1_HUMAN
NC score	0.793168 (rank : 397)	θ value	1.92812e-18 (rank : 304)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1057	Shared Neighborhood Hits	871
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

KPCG_MOUSE
NC score	0.793055 (rank : 398)	θ value	1.92812e-18 (rank : 303)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1123	Shared Neighborhood Hits	851
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCB_MOUSE
NC score	0.792917 (rank : 399)	θ value	5.99374e-20 (rank : 258)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1117	Shared Neighborhood Hits	854
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCG_HUMAN
NC score	0.792826 (rank : 400)	θ value	2.5182e-18 (rank : 314)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1126	Shared Neighborhood Hits	851
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PCTK2_HUMAN
NC score	0.792663 (rank : 401)	θ value	1.74796e-11 (rank : 593)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	822
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

KPCB_HUMAN
NC score	0.792616 (rank : 402)	θ value	5.99374e-20 (rank : 257)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1121	Shared Neighborhood Hits	854
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PCTK2_MOUSE
NC score	0.792437 (rank : 403)	θ value	1.02475e-11 (rank : 581)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

E2AK3_HUMAN
NC score	0.792244 (rank : 404)	θ value	4.76016e-09 (rank : 694)
Query Neighborhood Hits	1931	Target Neighborhood Hits	859	Shared Neighborhood Hits	828
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

ERN2_HUMAN
NC score	0.792067 (rank : 405)	θ value	1.33526e-19 (rank : 272)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	820
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

E2AK1_HUMAN
NC score	0.792048 (rank : 406)	θ value	1.02475e-11 (rank : 578)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

ERN1_MOUSE
NC score	0.792025 (rank : 407)	θ value	1.47974e-10 (rank : 621)
Query Neighborhood Hits	1931	Target Neighborhood Hits	823	Shared Neighborhood Hits	810
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK14_MOUSE
NC score	0.791767 (rank : 408)	θ value	2.69671e-12 (rank : 553)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK14_HUMAN
NC score	0.791530 (rank : 409)	θ value	2.69671e-12 (rank : 552)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK13_MOUSE
NC score	0.790708 (rank : 410)	θ value	2.69671e-12 (rank : 551)
Query Neighborhood Hits	1931	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

LATS1_MOUSE
NC score	0.790607 (rank : 411)	θ value	3.63628e-17 (rank : 358)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1027	Shared Neighborhood Hits	850
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

E2AK3_MOUSE
NC score	0.790119 (rank : 412)	θ value	4.76016e-09 (rank : 695)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	832
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

WNK3_HUMAN
NC score	0.789900 (rank : 413)	θ value	9.90251e-15 (rank : 443)
Query Neighborhood Hits	1931	Target Neighborhood Hits	948	Shared Neighborhood Hits	785
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

MK13_HUMAN
NC score	0.789623 (rank : 414)	θ value	5.43371e-13 (rank : 524)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	824
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MINK1_MOUSE
NC score	0.789011 (rank : 415)	θ value	4.91457e-14 (rank : 476)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1451	Shared Neighborhood Hits	898
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_HUMAN
NC score	0.788987 (rank : 416)	θ value	8.38298e-14 (rank : 483)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1477	Shared Neighborhood Hits	917
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

LATS2_MOUSE
NC score	0.788977 (rank : 417)	θ value	1.68911e-14 (rank : 449)
Query Neighborhood Hits	1931	Target Neighborhood Hits	879	Shared Neighborhood Hits	833
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

AL2S7_HUMAN
NC score	0.788774 (rank : 418)	θ value	2.43908e-13 (rank : 505)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	819
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ERN2_MOUSE
NC score	0.788728 (rank : 419)	θ value	6.20254e-17 (rank : 371)
Query Neighborhood Hits	1931	Target Neighborhood Hits	825	Shared Neighborhood Hits	811
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

TNIK_HUMAN
NC score	0.788667 (rank : 420)	θ value	2.88119e-14 (rank : 465)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1570	Shared Neighborhood Hits	916
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

MOK_HUMAN
NC score	0.788553 (rank : 421)	θ value	1.133e-10 (rank : 620)
Query Neighborhood Hits	1931	Target Neighborhood Hits	807	Shared Neighborhood Hits	800
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MK04_HUMAN
NC score	0.788452 (rank : 422)	θ value	2.20605e-14 (rank : 458)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	819
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

LATS2_HUMAN
NC score	0.788399 (rank : 423)	θ value	4.91457e-14 (rank : 475)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	834
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

MK07_MOUSE
NC score	0.787909 (rank : 424)	θ value	1.86753e-13 (rank : 504)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1054	Shared Neighborhood Hits	900
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

NLK_MOUSE
NC score	0.787693 (rank : 425)	θ value	1.58096e-12 (rank : 545)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	828
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

MK09_HUMAN
NC score	0.787693 (rank : 426)	θ value	3.52202e-12 (rank : 558)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	831
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

NLK_HUMAN
NC score	0.787660 (rank : 427)	θ value	1.58096e-12 (rank : 544)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	828
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

MOK_MOUSE
NC score	0.787349 (rank : 428)	θ value	9.26847e-13 (rank : 538)
Query Neighborhood Hits	1931	Target Neighborhood Hits	796	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MK04_MOUSE
NC score	0.787182 (rank : 429)	θ value	4.91457e-14 (rank : 477)
Query Neighborhood Hits	1931	Target Neighborhood Hits	852	Shared Neighborhood Hits	817
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

MK07_HUMAN
NC score	0.787145 (rank : 430)	θ value	8.38298e-14 (rank : 484)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1087	Shared Neighborhood Hits	913
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

CD2L7_HUMAN
NC score	0.786873 (rank : 431)	θ value	4.76016e-09 (rank : 693)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1275	Shared Neighborhood Hits	925
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDK4_MOUSE
NC score	0.786418 (rank : 432)	θ value	4.30538e-10 (rank : 642)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

MK11_MOUSE
NC score	0.786407 (rank : 433)	θ value	3.52202e-12 (rank : 560)
Query Neighborhood Hits	1931	Target Neighborhood Hits	835	Shared Neighborhood Hits	824
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

CDK4_HUMAN
NC score	0.786228 (rank : 434)	θ value	4.30538e-10 (rank : 641)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	826
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

MK03_HUMAN
NC score	0.785471 (rank : 435)	θ value	7.09661e-13 (rank : 529)
Query Neighborhood Hits	1931	Target Neighborhood Hits	837	Shared Neighborhood Hits	826
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
NC score	0.785440 (rank : 436)	θ value	7.09661e-13 (rank : 530)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	826
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

CD2L5_HUMAN
NC score	0.785053 (rank : 437)	θ value	2.79066e-09 (rank : 681)
Query Neighborhood Hits	1931	Target Neighborhood Hits	987	Shared Neighborhood Hits	853
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CSK21_MOUSE
NC score	0.784993 (rank : 438)	θ value	1.25267e-09 (rank : 662)
Query Neighborhood Hits	1931	Target Neighborhood Hits	770	Shared Neighborhood Hits	764
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CD2L5_MOUSE
NC score	0.784817 (rank : 439)	θ value	2.79066e-09 (rank : 682)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1011	Shared Neighborhood Hits	851
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CSK21_HUMAN
NC score	0.784733 (rank : 440)	θ value	3.29651e-10 (rank : 638)
Query Neighborhood Hits	1931	Target Neighborhood Hits	772	Shared Neighborhood Hits	764
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

MK09_MOUSE
NC score	0.784246 (rank : 441)	θ value	3.52202e-12 (rank : 559)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	827
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

CDK10_HUMAN
NC score	0.783801 (rank : 442)	θ value	1.33837e-11 (rank : 586)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	826
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

MK08_MOUSE
NC score	0.783281 (rank : 443)	θ value	4.16044e-13 (rank : 519)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	825
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

TAOK2_MOUSE
NC score	0.783271 (rank : 444)	θ value	4.58923e-20 (rank : 256)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1373	Shared Neighborhood Hits	882
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

MK08_HUMAN
NC score	0.782696 (rank : 445)	θ value	4.16044e-13 (rank : 518)
Query Neighborhood Hits	1931	Target Neighborhood Hits	834	Shared Neighborhood Hits	825
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK01_HUMAN
NC score	0.782616 (rank : 446)	θ value	1.42992e-13 (rank : 495)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	825
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
NC score	0.782433 (rank : 447)	θ value	1.86753e-13 (rank : 503)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	825
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

WNK4_MOUSE
NC score	0.782130 (rank : 448)	θ value	1.68911e-14 (rank : 452)
Query Neighborhood Hits	1931	Target Neighborhood Hits	961	Shared Neighborhood Hits	806
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

M3K13_HUMAN
NC score	0.782096 (rank : 449)	θ value	3.17815e-21 (rank : 216)
Query Neighborhood Hits	1931	Target Neighborhood Hits	911	Shared Neighborhood Hits	845
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

CI096_HUMAN
NC score	0.781967 (rank : 450)	θ value	1.69304e-06 (rank : 822)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	799
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

MK10_HUMAN
NC score	0.781584 (rank : 451)	θ value	1.58096e-12 (rank : 543)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	826
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
NC score	0.781276 (rank : 452)	θ value	1.2105e-12 (rank : 542)
Query Neighborhood Hits	1931	Target Neighborhood Hits	849	Shared Neighborhood Hits	827
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

WNK1_HUMAN
NC score	0.781152 (rank : 453)	θ value	5.8054e-15 (rank : 437)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1158	Shared Neighborhood Hits	854
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

CDK9_HUMAN
NC score	0.780641 (rank : 454)	θ value	1.9326e-10 (rank : 627)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

MK11_HUMAN
NC score	0.779959 (rank : 455)	θ value	3.29651e-10 (rank : 639)
Query Neighborhood Hits	1931	Target Neighborhood Hits	823	Shared Neighborhood Hits	819
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

CSK22_MOUSE
NC score	0.779956 (rank : 456)	θ value	5.08577e-11 (rank : 610)
Query Neighborhood Hits	1931	Target Neighborhood Hits	758	Shared Neighborhood Hits	757
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

WNK1_MOUSE
NC score	0.779910 (rank : 457)	θ value	5.8054e-15 (rank : 438)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1179	Shared Neighborhood Hits	860
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

CDK9_MOUSE
NC score	0.779895 (rank : 458)	θ value	2.52405e-10 (rank : 633)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CSK22_HUMAN
NC score	0.779801 (rank : 459)	θ value	6.64225e-11 (rank : 611)
Query Neighborhood Hits	1931	Target Neighborhood Hits	758	Shared Neighborhood Hits	757
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

WEE1_MOUSE
NC score	0.779788 (rank : 460)	θ value	3.52202e-12 (rank : 563)
Query Neighborhood Hits	1931	Target Neighborhood Hits	794	Shared Neighborhood Hits	762
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

HIPK4_HUMAN
NC score	0.778716 (rank : 461)	θ value	5.81887e-07 (rank : 801)
Query Neighborhood Hits	1931	Target Neighborhood Hits	799	Shared Neighborhood Hits	784
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

MK06_HUMAN
NC score	0.777814 (rank : 462)	θ value	1.42992e-13 (rank : 496)
Query Neighborhood Hits	1931	Target Neighborhood Hits	815	Shared Neighborhood Hits	795
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
NC score	0.777516 (rank : 463)	θ value	1.09485e-13 (rank : 489)
Query Neighborhood Hits	1931	Target Neighborhood Hits	818	Shared Neighborhood Hits	796
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

WNK4_HUMAN
NC score	0.776962 (rank : 464)	θ value	1.68911e-14 (rank : 451)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1043	Shared Neighborhood Hits	823
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

STK10_HUMAN
NC score	0.776901 (rank : 465)	θ value	3.62785e-25 (rank : 131)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1921	Shared Neighborhood Hits	932
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

E2AK4_HUMAN
NC score	0.776779 (rank : 466)	θ value	3.41135e-07 (rank : 790)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1012	Shared Neighborhood Hits	845
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

DAPK1_HUMAN
NC score	0.776191 (rank : 467)	θ value	7.52953e-39 (rank : 28)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1130	Shared Neighborhood Hits	842
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

M4K4_HUMAN
NC score	0.776040 (rank : 468)	θ value	4.30538e-10 (rank : 644)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1589	Shared Neighborhood Hits	878
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

TAOK3_MOUSE
NC score	0.774637 (rank : 469)	θ value	1.24977e-17 (rank : 342)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1458	Shared Neighborhood Hits	867
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

DYRK3_HUMAN
NC score	0.774285 (rank : 470)	θ value	5.25075e-16 (rank : 404)
Query Neighborhood Hits	1931	Target Neighborhood Hits	798	Shared Neighborhood Hits	788
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

M3K12_MOUSE
NC score	0.774167 (rank : 471)	θ value	3.88503e-19 (rank : 283)
Query Neighborhood Hits	1931	Target Neighborhood Hits	957	Shared Neighborhood Hits	862
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
NC score	0.774060 (rank : 472)	θ value	3.88503e-19 (rank : 282)
Query Neighborhood Hits	1931	Target Neighborhood Hits	940	Shared Neighborhood Hits	856
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

CD2L6_MOUSE
NC score	0.773528 (rank : 473)	θ value	1.33837e-11 (rank : 585)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	824
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L6_HUMAN
NC score	0.773459 (rank : 474)	θ value	1.33837e-11 (rank : 584)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	822
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

E2AK4_MOUSE
NC score	0.773330 (rank : 475)	θ value	1.69304e-06 (rank : 823)
Query Neighborhood Hits	1931	Target Neighborhood Hits	984	Shared Neighborhood Hits	842
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

MRCKG_HUMAN
NC score	0.772942 (rank : 476)	θ value	4.74913e-17 (rank : 366)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1519	Shared Neighborhood Hits	879
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

WNK2_HUMAN
NC score	0.772422 (rank : 477)	θ value	7.84624e-12 (rank : 576)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1407	Shared Neighborhood Hits	922
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

TAOK3_HUMAN
NC score	0.772353 (rank : 478)	θ value	1.92812e-18 (rank : 310)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1494	Shared Neighborhood Hits	873
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

DYRK2_HUMAN
NC score	0.772238 (rank : 479)	θ value	7.84624e-12 (rank : 571)
Query Neighborhood Hits	1931	Target Neighborhood Hits	799	Shared Neighborhood Hits	786
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

DAPK1_MOUSE
NC score	0.772167 (rank : 480)	θ value	1.28434e-38 (rank : 29)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1138	Shared Neighborhood Hits	845
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

M4K4_MOUSE
NC score	0.772022 (rank : 481)	θ value	5.62301e-10 (rank : 651)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1560	Shared Neighborhood Hits	877
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MRCKG_MOUSE
NC score	0.771993 (rank : 482)	θ value	5.60996e-18 (rank : 329)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1466	Shared Neighborhood Hits	864
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

BMP2K_MOUSE
NC score	0.771727 (rank : 483)	θ value	1.63604e-09 (rank : 667)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	784
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

RIPK5_HUMAN
NC score	0.771273 (rank : 484)	θ value	1.53129e-07 (rank : 771)
Query Neighborhood Hits	1931	Target Neighborhood Hits	864	Shared Neighborhood Hits	838
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

BMP2K_HUMAN
NC score	0.770792 (rank : 485)	θ value	1.06045e-08 (rank : 711)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	784
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

RIPK5_MOUSE
NC score	0.770724 (rank : 486)	θ value	1.99992e-07 (rank : 780)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	839
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

GAK_HUMAN
NC score	0.770640 (rank : 487)	θ value	6.64225e-11 (rank : 613)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1028	Shared Neighborhood Hits	870
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

CDK8_HUMAN
NC score	0.770603 (rank : 488)	θ value	2.28291e-11 (rank : 595)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	817
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

PTK7_HUMAN
NC score	0.769924 (rank : 489)	θ value	8.08199e-25 (rank : 139)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1103	Shared Neighborhood Hits	1057
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

DYR1B_MOUSE
NC score	0.768757 (rank : 490)	θ value	3.76295e-14 (rank : 467)
Query Neighborhood Hits	1931	Target Neighborhood Hits	799	Shared Neighborhood Hits	775
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

AAK1_MOUSE
NC score	0.768681 (rank : 491)	θ value	4.0297e-08 (rank : 743)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1051	Shared Neighborhood Hits	875
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

WEE1_HUMAN
NC score	0.768495 (rank : 492)	θ value	2.98157e-11 (rank : 603)
Query Neighborhood Hits	1931	Target Neighborhood Hits	777	Shared Neighborhood Hits	742
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

AAK1_HUMAN
NC score	0.768377 (rank : 493)	θ value	1.53129e-07 (rank : 768)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1077	Shared Neighborhood Hits	881
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

TESK2_MOUSE
NC score	0.767940 (rank : 494)	θ value	1.09485e-13 (rank : 491)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	814
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_HUMAN
NC score	0.767901 (rank : 495)	θ value	2.0648e-12 (rank : 550)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	820
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

GAK_MOUSE
NC score	0.767877 (rank : 496)	θ value	5.62301e-10 (rank : 649)
Query Neighborhood Hits	1931	Target Neighborhood Hits	964	Shared Neighborhood Hits	842
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

CD2L2_HUMAN
NC score	0.767462 (rank : 497)	θ value	1.06045e-08 (rank : 713)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1439	Shared Neighborhood Hits	872
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

TESK1_MOUSE
NC score	0.767419 (rank : 498)	θ value	9.59137e-10 (rank : 659)
Query Neighborhood Hits	1931	Target Neighborhood Hits	862	Shared Neighborhood Hits	820
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

M3K7_MOUSE
NC score	0.766375 (rank : 499)	θ value	1.47974e-10 (rank : 625)
Query Neighborhood Hits	1931	Target Neighborhood Hits	892	Shared Neighborhood Hits	832
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.766249 (rank : 500)	θ value	1.47974e-10 (rank : 624)
Query Neighborhood Hits	1931	Target Neighborhood Hits	892	Shared Neighborhood Hits	831
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

TESK1_HUMAN
NC score	0.766009 (rank : 501)	θ value	1.63604e-09 (rank : 671)
Query Neighborhood Hits	1931	Target Neighborhood Hits	864	Shared Neighborhood Hits	822
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

DYR1B_HUMAN
NC score	0.765155 (rank : 502)	θ value	3.18553e-13 (rank : 512)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	777
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

CD2L1_HUMAN
NC score	0.764422 (rank : 503)	θ value	1.06045e-08 (rank : 712)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1467	Shared Neighborhood Hits	870
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
NC score	0.764197 (rank : 504)	θ value	2.79066e-09 (rank : 680)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1463	Shared Neighborhood Hits	868
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

HIPK3_MOUSE
NC score	0.762372 (rank : 505)	θ value	2.43908e-13 (rank : 508)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	804
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

RIPK1_HUMAN
NC score	0.762056 (rank : 506)	θ value	2.61198e-07 (rank : 786)
Query Neighborhood Hits	1931	Target Neighborhood Hits	891	Shared Neighborhood Hits	841
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

IRAK4_MOUSE
NC score	0.761301 (rank : 507)	θ value	0.000158464 (rank : 938)
Query Neighborhood Hits	1931	Target Neighborhood Hits	820	Shared Neighborhood Hits	811
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

TAOK1_MOUSE
NC score	0.761214 (rank : 508)	θ value	8.65492e-19 (rank : 296)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1720	Shared Neighborhood Hits	884
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK1_HUMAN
NC score	0.760820 (rank : 509)	θ value	1.13037e-18 (rank : 299)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1734	Shared Neighborhood Hits	888
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

HIPK3_HUMAN
NC score	0.760409 (rank : 510)	θ value	2.43908e-13 (rank : 507)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	801
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK1_HUMAN
NC score	0.760098 (rank : 511)	θ value	1.86753e-13 (rank : 500)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	792
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.759950 (rank : 512)	θ value	1.86753e-13 (rank : 501)
Query Neighborhood Hits	1931	Target Neighborhood Hits	838	Shared Neighborhood Hits	790
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

DYRK4_HUMAN
NC score	0.759192 (rank : 513)	θ value	2.43908e-13 (rank : 506)
Query Neighborhood Hits	1931	Target Neighborhood Hits	750	Shared Neighborhood Hits	742
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

HIPK2_HUMAN
NC score	0.758867 (rank : 514)	θ value	4.91457e-14 (rank : 473)
Query Neighborhood Hits	1931	Target Neighborhood Hits	845	Shared Neighborhood Hits	790
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

TRIB2_HUMAN
NC score	0.758347 (rank : 515)	θ value	4.76016e-09 (rank : 701)
Query Neighborhood Hits	1931	Target Neighborhood Hits	657	Shared Neighborhood Hits	654
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

HIPK2_MOUSE
NC score	0.758095 (rank : 516)	θ value	4.91457e-14 (rank : 474)
Query Neighborhood Hits	1931	Target Neighborhood Hits	871	Shared Neighborhood Hits	791
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

TRIB2_MOUSE
NC score	0.757956 (rank : 517)	θ value	3.64472e-09 (rank : 690)
Query Neighborhood Hits	1931	Target Neighborhood Hits	653	Shared Neighborhood Hits	650
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

UHMK1_HUMAN
NC score	0.757920 (rank : 518)	θ value	1.43324e-05 (rank : 881)
Query Neighborhood Hits	1931	Target Neighborhood Hits	808	Shared Neighborhood Hits	767
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

M3K11_HUMAN
NC score	0.756914 (rank : 519)	θ value	4.02038e-16 (rank : 402)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1136	Shared Neighborhood Hits	904
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K9_HUMAN
NC score	0.756911 (rank : 520)	θ value	9.90251e-15 (rank : 441)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1123	Shared Neighborhood Hits	883
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

UHMK1_MOUSE
NC score	0.756488 (rank : 521)	θ value	2.44474e-05 (rank : 899)
Query Neighborhood Hits	1931	Target Neighborhood Hits	809	Shared Neighborhood Hits	767
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

DYR1A_MOUSE
NC score	0.756447 (rank : 522)	θ value	1.02475e-11 (rank : 577)
Query Neighborhood Hits	1931	Target Neighborhood Hits	762	Shared Neighborhood Hits	751
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1A_HUMAN
NC score	0.756376 (rank : 523)	θ value	1.33837e-11 (rank : 587)
Query Neighborhood Hits	1931	Target Neighborhood Hits	764	Shared Neighborhood Hits	751
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

RIPK1_MOUSE
NC score	0.755754 (rank : 524)	θ value	1.38499e-08 (rank : 716)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	832
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

IRAK4_HUMAN
NC score	0.755697 (rank : 525)	θ value	0.000121331 (rank : 935)
Query Neighborhood Hits	1931	Target Neighborhood Hits	816	Shared Neighborhood Hits	809
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

STK10_MOUSE
NC score	0.755133 (rank : 526)	θ value	7.56453e-23 (rank : 179)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2132	Shared Neighborhood Hits	927
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

M3K10_HUMAN
NC score	0.754707 (rank : 527)	θ value	3.52202e-12 (rank : 557)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1071	Shared Neighborhood Hits	864
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

WEE1B_MOUSE
NC score	0.753385 (rank : 528)	θ value	8.38298e-14 (rank : 486)
Query Neighborhood Hits	1931	Target Neighborhood Hits	765	Shared Neighborhood Hits	740
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

RAF1_MOUSE
NC score	0.753186 (rank : 529)	θ value	3.29651e-10 (rank : 640)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	843
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_HUMAN
NC score	0.752878 (rank : 530)	θ value	1.9326e-10 (rank : 630)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	841
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

BRAF1_HUMAN
NC score	0.752777 (rank : 531)	θ value	1.33837e-11 (rank : 583)
Query Neighborhood Hits	1931	Target Neighborhood Hits	883	Shared Neighborhood Hits	837
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

WEE1B_HUMAN
NC score	0.752213 (rank : 532)	θ value	3.52202e-12 (rank : 562)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	753
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

MOS_HUMAN
NC score	0.751528 (rank : 533)	θ value	5.62301e-10 (rank : 652)
Query Neighborhood Hits	1931	Target Neighborhood Hits	829	Shared Neighborhood Hits	826
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MOS_MOUSE
NC score	0.750783 (rank : 534)	θ value	2.98157e-11 (rank : 601)
Query Neighborhood Hits	1931	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MLTK_MOUSE
NC score	0.750446 (rank : 535)	θ value	1.25267e-09 (rank : 665)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	822
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.750015 (rank : 536)	θ value	4.30538e-10 (rank : 645)
Query Neighborhood Hits	1931	Target Neighborhood Hits	911	Shared Neighborhood Hits	830
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

FGFR1_HUMAN
NC score	0.749026 (rank : 537)	θ value	1.16975e-15 (rank : 416)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1069	Shared Neighborhood Hits	1046
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
NC score	0.748929 (rank : 538)	θ value	1.52774e-15 (rank : 420)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1068	Shared Neighborhood Hits	1046
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

ARAF_HUMAN
NC score	0.747793 (rank : 539)	θ value	7.34386e-10 (rank : 653)
Query Neighborhood Hits	1931	Target Neighborhood Hits	924	Shared Neighborhood Hits	847
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
NC score	0.747443 (rank : 540)	θ value	5.62301e-10 (rank : 646)
Query Neighborhood Hits	1931	Target Neighborhood Hits	874	Shared Neighborhood Hits	835
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

M3KL4_HUMAN
NC score	0.745126 (rank : 541)	θ value	2.28291e-11 (rank : 596)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1087	Shared Neighborhood Hits	855
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

PRP4B_HUMAN
NC score	0.744819 (rank : 542)	θ value	1.80886e-08 (rank : 723)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1030	Shared Neighborhood Hits	785
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

FGFR2_HUMAN
NC score	0.744007 (rank : 543)	θ value	8.67504e-11 (rank : 616)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1062	Shared Neighborhood Hits	1040
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

PRP4B_MOUSE
NC score	0.743137 (rank : 544)	θ value	1.80886e-08 (rank : 724)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1040	Shared Neighborhood Hits	787
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

CLK1_HUMAN
NC score	0.742845 (rank : 545)	θ value	1.53129e-07 (rank : 770)
Query Neighborhood Hits	1931	Target Neighborhood Hits	756	Shared Neighborhood Hits	742
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CLK1_MOUSE
NC score	0.742023 (rank : 546)	θ value	3.41135e-07 (rank : 788)
Query Neighborhood Hits	1931	Target Neighborhood Hits	760	Shared Neighborhood Hits	749
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

FGFR2_MOUSE
NC score	0.740855 (rank : 547)	θ value	6.64225e-11 (rank : 612)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1062	Shared Neighborhood Hits	1038
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_MOUSE
NC score	0.739411 (rank : 548)	θ value	4.30538e-10 (rank : 643)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1059	Shared Neighborhood Hits	1041
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

RIPK3_MOUSE
NC score	0.738820 (rank : 549)	θ value	0.00665767 (rank : 1043)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	825
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

FGFR3_HUMAN
NC score	0.737581 (rank : 550)	θ value	1.47974e-10 (rank : 622)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1042	Shared Neighborhood Hits	1029
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

LIMK2_HUMAN
NC score	0.737181 (rank : 551)	θ value	3.08544e-08 (rank : 740)
Query Neighborhood Hits	1931	Target Neighborhood Hits	986	Shared Neighborhood Hits	819
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

CLK4_HUMAN
NC score	0.737008 (rank : 552)	θ value	6.43352e-06 (rank : 861)
Query Neighborhood Hits	1931	Target Neighborhood Hits	759	Shared Neighborhood Hits	752
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

MUSK_HUMAN
NC score	0.736311 (rank : 553)	θ value	2.43343e-21 (rank : 212)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1074	Shared Neighborhood Hits	1046
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

CLK4_MOUSE
NC score	0.735898 (rank : 554)	θ value	2.21117e-06 (rank : 832)
Query Neighborhood Hits	1931	Target Neighborhood Hits	759	Shared Neighborhood Hits	751
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

RIPK3_HUMAN
NC score	0.735191 (rank : 555)	θ value	0.00390308 (rank : 1024)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	811
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

LIMK2_MOUSE
NC score	0.734558 (rank : 556)	θ value	8.11959e-09 (rank : 708)
Query Neighborhood Hits	1931	Target Neighborhood Hits	998	Shared Neighborhood Hits	821
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

KSR2_HUMAN
NC score	0.734519 (rank : 557)	θ value	1.29631e-06 (rank : 816)
Query Neighborhood Hits	1931	Target Neighborhood Hits	920	Shared Neighborhood Hits	839
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

LIMK1_HUMAN
NC score	0.734278 (rank : 558)	θ value	5.62301e-10 (rank : 650)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1005	Shared Neighborhood Hits	827
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

FGFR4_HUMAN
NC score	0.734232 (rank : 559)	θ value	4.16044e-13 (rank : 517)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1037	Shared Neighborhood Hits	1025
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

LIMK1_MOUSE
NC score	0.733634 (rank : 560)	θ value	4.76016e-09 (rank : 698)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1008	Shared Neighborhood Hits	826
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

CLK2_HUMAN
NC score	0.733039 (rank : 561)	θ value	5.26297e-08 (rank : 746)
Query Neighborhood Hits	1931	Target Neighborhood Hits	752	Shared Neighborhood Hits	736
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

MUSK_MOUSE
NC score	0.732970 (rank : 562)	θ value	2.43343e-21 (rank : 213)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1057	Shared Neighborhood Hits	1035
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

TRIB1_HUMAN
NC score	0.731677 (rank : 563)	θ value	8.40245e-06 (rank : 870)
Query Neighborhood Hits	1931	Target Neighborhood Hits	598	Shared Neighborhood Hits	592
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
NC score	0.730226 (rank : 564)	θ value	4.92598e-06 (rank : 857)
Query Neighborhood Hits	1931	Target Neighborhood Hits	593	Shared Neighborhood Hits	589
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

ROCK2_HUMAN
NC score	0.725889 (rank : 565)	θ value	1.99067e-23 (rank : 166)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2073	Shared Neighborhood Hits	894
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

VGFR1_MOUSE
NC score	0.724194 (rank : 566)	θ value	9.59137e-10 (rank : 660)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1118	Shared Neighborhood Hits	1072
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

MRCKA_HUMAN
NC score	0.722983 (rank : 567)	θ value	8.10077e-17 (rank : 377)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1999	Shared Neighborhood Hits	889
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

ROCK1_HUMAN
NC score	0.721758 (rank : 568)	θ value	1.42661e-21 (rank : 206)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2000	Shared Neighborhood Hits	886
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

CLK2_MOUSE
NC score	0.721165 (rank : 569)	θ value	1.29631e-06 (rank : 814)
Query Neighborhood Hits	1931	Target Neighborhood Hits	743	Shared Neighborhood Hits	730
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

VGFR1_HUMAN
NC score	0.720171 (rank : 570)	θ value	2.28291e-11 (rank : 599)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1109	Shared Neighborhood Hits	1068
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

TRIB3_MOUSE
NC score	0.720152 (rank : 571)	θ value	2.13673e-09 (rank : 678)
Query Neighborhood Hits	1931	Target Neighborhood Hits	578	Shared Neighborhood Hits	575
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

AL2S2_HUMAN
NC score	0.719983 (rank : 572)	θ value	6.43352e-06 (rank : 858)
Query Neighborhood Hits	1931	Target Neighborhood Hits	727	Shared Neighborhood Hits	717
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

ROCK2_MOUSE
NC score	0.719632 (rank : 573)	θ value	1.6852e-22 (rank : 186)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2072	Shared Neighborhood Hits	892
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

CTRO_HUMAN
NC score	0.719418 (rank : 574)	θ value	3.07829e-16 (rank : 395)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2092	Shared Neighborhood Hits	910
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

JAK2_HUMAN
NC score	0.718914 (rank : 575)	θ value	2.13673e-09 (rank : 674)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	828
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
NC score	0.717739 (rank : 576)	θ value	4.76016e-09 (rank : 697)
Query Neighborhood Hits	1931	Target Neighborhood Hits	839	Shared Neighborhood Hits	823
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK3_MOUSE
NC score	0.717314 (rank : 577)	θ value	2.21117e-06 (rank : 834)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	811
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

NTRK2_MOUSE
NC score	0.717224 (rank : 578)	θ value	7.59969e-07 (rank : 807)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1088	Shared Neighborhood Hits	981
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK2_HUMAN
NC score	0.716884 (rank : 579)	θ value	7.59969e-07 (rank : 806)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1081	Shared Neighborhood Hits	983
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

MYO3A_MOUSE
NC score	0.715869 (rank : 580)	θ value	3.52202e-12 (rank : 561)
Query Neighborhood Hits	1931	Target Neighborhood Hits	902	Shared Neighborhood Hits	836
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

FGFR4_MOUSE
NC score	0.715060 (rank : 581)	θ value	2.20605e-14 (rank : 453)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1026	Shared Neighborhood Hits	1011
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

PINK1_MOUSE
NC score	0.714499 (rank : 582)	θ value	7.1131e-05 (rank : 923)
Query Neighborhood Hits	1931	Target Neighborhood Hits	726	Shared Neighborhood Hits	721
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

JAK3_HUMAN
NC score	0.712772 (rank : 583)	θ value	3.64472e-09 (rank : 686)
Query Neighborhood Hits	1931	Target Neighborhood Hits	827	Shared Neighborhood Hits	816
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

VGFR2_MOUSE
NC score	0.712425 (rank : 584)	θ value	2.69671e-12 (rank : 554)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1089	Shared Neighborhood Hits	1046
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

TYK2_HUMAN
NC score	0.711841 (rank : 585)	θ value	8.67504e-11 (rank : 618)
Query Neighborhood Hits	1931	Target Neighborhood Hits	841	Shared Neighborhood Hits	830
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

CLK3_HUMAN
NC score	0.710946 (rank : 586)	θ value	1.87187e-05 (rank : 883)
Query Neighborhood Hits	1931	Target Neighborhood Hits	748	Shared Neighborhood Hits	732
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

VGFR2_HUMAN
NC score	0.710565 (rank : 587)	θ value	7.09661e-13 (rank : 536)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1103	Shared Neighborhood Hits	1051
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

MRCKB_MOUSE
NC score	0.710368 (rank : 588)	θ value	5.25075e-16 (rank : 408)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2180	Shared Neighborhood Hits	914
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

CLK3_MOUSE
NC score	0.710292 (rank : 589)	θ value	1.87187e-05 (rank : 884)
Query Neighborhood Hits	1931	Target Neighborhood Hits	761	Shared Neighborhood Hits	732
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

PINK1_HUMAN
NC score	0.709086 (rank : 590)	θ value	1.69304e-06 (rank : 831)
Query Neighborhood Hits	1931	Target Neighborhood Hits	741	Shared Neighborhood Hits	729
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

MYO3A_HUMAN
NC score	0.708804 (rank : 591)	θ value	8.38298e-14 (rank : 485)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1033	Shared Neighborhood Hits	846
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

AL2S2_MOUSE
NC score	0.708241 (rank : 592)	θ value	4.92598e-06 (rank : 851)
Query Neighborhood Hits	1931	Target Neighborhood Hits	709	Shared Neighborhood Hits	695
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

KSR1_MOUSE
NC score	0.707633 (rank : 593)	θ value	2.44474e-05 (rank : 895)
Query Neighborhood Hits	1931	Target Neighborhood Hits	870	Shared Neighborhood Hits	815
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

ROCK1_MOUSE
NC score	0.707046 (rank : 594)	θ value	1.42661e-21 (rank : 207)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2126	Shared Neighborhood Hits	899
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

TYK2_MOUSE
NC score	0.706456 (rank : 595)	θ value	1.38499e-08 (rank : 717)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	833
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

MYO3B_HUMAN
NC score	0.705676 (rank : 596)	θ value	1.52774e-15 (rank : 425)
Query Neighborhood Hits	1931	Target Neighborhood Hits	923	Shared Neighborhood Hits	843
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

MRCKB_HUMAN
NC score	0.703367 (rank : 597)	θ value	1.058e-16 (rank : 381)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2239	Shared Neighborhood Hits	922
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

LRRK1_HUMAN
NC score	0.702338 (rank : 598)	θ value	4.1701e-05 (rank : 909)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1237	Shared Neighborhood Hits	846
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

FES_MOUSE
NC score	0.701842 (rank : 599)	θ value	1.63604e-09 (rank : 669)
Query Neighborhood Hits	1931	Target Neighborhood Hits	980	Shared Neighborhood Hits	816
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_HUMAN
NC score	0.701235 (rank : 600)	θ value	2.52405e-10 (rank : 636)
Query Neighborhood Hits	1931	Target Neighborhood Hits	978	Shared Neighborhood Hits	811
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TYRO3_HUMAN
NC score	0.701232 (rank : 601)	θ value	3.77169e-06 (rank : 850)
Query Neighborhood Hits	1931	Target Neighborhood Hits	995	Shared Neighborhood Hits	964
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

JAK1_HUMAN
NC score	0.700809 (rank : 602)	θ value	9.29e-05 (rank : 931)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	828
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

LRRK1_MOUSE
NC score	0.700600 (rank : 603)	θ value	3.19293e-05 (rank : 903)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1267	Shared Neighborhood Hits	851
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

TRIB3_HUMAN
NC score	0.700217 (rank : 604)	θ value	3.64472e-09 (rank : 691)
Query Neighborhood Hits	1931	Target Neighborhood Hits	519	Shared Neighborhood Hits	517
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

PTK6_HUMAN
NC score	0.700099 (rank : 605)	θ value	7.09661e-13 (rank : 535)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1020	Shared Neighborhood Hits	848
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TYRO3_MOUSE
NC score	0.699670 (rank : 606)	θ value	6.43352e-06 (rank : 862)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1007	Shared Neighborhood Hits	973
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

CTRO_MOUSE
NC score	0.698504 (rank : 607)	θ value	3.76295e-14 (rank : 466)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2344	Shared Neighborhood Hits	919
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ROR1_MOUSE
NC score	0.698379 (rank : 608)	θ value	6.87365e-08 (rank : 756)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1025	Shared Neighborhood Hits	987
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

PTK6_MOUSE
NC score	0.698056 (rank : 609)	θ value	1.33837e-11 (rank : 591)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1026	Shared Neighborhood Hits	850
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

KSR1_HUMAN
NC score	0.697678 (rank : 610)	θ value	4.1701e-05 (rank : 907)
Query Neighborhood Hits	1931	Target Neighborhood Hits	867	Shared Neighborhood Hits	805
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

ROR1_HUMAN
NC score	0.696909 (rank : 611)	θ value	3.41135e-07 (rank : 797)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1018	Shared Neighborhood Hits	980
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

JAK1_MOUSE
NC score	0.693984 (rank : 612)	θ value	0.000270298 (rank : 952)
Query Neighborhood Hits	1931	Target Neighborhood Hits	854	Shared Neighborhood Hits	826
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

VGFR3_MOUSE
NC score	0.691389 (rank : 613)	θ value	2.98157e-11 (rank : 602)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1056	Shared Neighborhood Hits	1024
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

LRRK2_HUMAN
NC score	0.691299 (rank : 614)	θ value	2.43908e-13 (rank : 509)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1382	Shared Neighborhood Hits	861
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

RIPK2_MOUSE
NC score	0.690529 (rank : 615)	θ value	0.000786445 (rank : 980)
Query Neighborhood Hits	1931	Target Neighborhood Hits	776	Shared Neighborhood Hits	755
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK2_HUMAN
NC score	0.690405 (rank : 616)	θ value	0.00228821 (rank : 1004)
Query Neighborhood Hits	1931	Target Neighborhood Hits	774	Shared Neighborhood Hits	756
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

NTRK3_HUMAN
NC score	0.688436 (rank : 617)	θ value	7.1131e-05 (rank : 922)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1115	Shared Neighborhood Hits	964
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

KSYK_MOUSE
NC score	0.687652 (rank : 618)	θ value	5.26297e-08 (rank : 751)
Query Neighborhood Hits	1931	Target Neighborhood Hits	944	Shared Neighborhood Hits	840
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.687610 (rank : 619)	θ value	3.08544e-08 (rank : 739)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	819
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TEC_MOUSE
NC score	0.686977 (rank : 620)	θ value	4.76016e-09 (rank : 700)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1006	Shared Neighborhood Hits	837
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VGFR3_HUMAN
NC score	0.686883 (rank : 621)	θ value	1.17247e-07 (rank : 766)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1037	Shared Neighborhood Hits	1014
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

ZAP70_HUMAN
NC score	0.686721 (rank : 622)	θ value	1.53129e-07 (rank : 772)
Query Neighborhood Hits	1931	Target Neighborhood Hits	893	Shared Neighborhood Hits	823
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ROR2_HUMAN
NC score	0.685302 (rank : 623)	θ value	2.36244e-08 (rank : 733)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1014	Shared Neighborhood Hits	965
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

FAK1_HUMAN
NC score	0.685096 (rank : 624)	θ value	1.63604e-09 (rank : 668)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

ZAP70_MOUSE
NC score	0.684689 (rank : 625)	θ value	1.17247e-07 (rank : 767)
Query Neighborhood Hits	1931	Target Neighborhood Hits	905	Shared Neighborhood Hits	827
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CSK_MOUSE
NC score	0.684652 (rank : 626)	θ value	3.08544e-08 (rank : 735)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	846
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

FAK1_MOUSE
NC score	0.684460 (rank : 627)	θ value	6.21693e-09 (rank : 702)
Query Neighborhood Hits	1931	Target Neighborhood Hits	850	Shared Neighborhood Hits	819
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FER_HUMAN
NC score	0.683356 (rank : 628)	θ value	1.38499e-08 (rank : 714)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1278	Shared Neighborhood Hits	830
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

TEC_HUMAN
NC score	0.682311 (rank : 629)	θ value	2.13673e-09 (rank : 677)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1006	Shared Neighborhood Hits	839
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
NC score	0.681609 (rank : 630)	θ value	6.00763e-12 (rank : 570)
Query Neighborhood Hits	1931	Target Neighborhood Hits	971	Shared Neighborhood Hits	831
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

RPKL1_MOUSE
NC score	0.680421 (rank : 631)	θ value	0.00298849 (rank : 1011)
Query Neighborhood Hits	1931	Target Neighborhood Hits	704	Shared Neighborhood Hits	665
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

ABL1_MOUSE
NC score	0.679866 (rank : 632)	θ value	1.25267e-09 (rank : 661)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1178	Shared Neighborhood Hits	904
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_HUMAN
NC score	0.679074 (rank : 633)	θ value	2.79066e-09 (rank : 679)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1220	Shared Neighborhood Hits	908
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

RPKL1_HUMAN
NC score	0.678475 (rank : 634)	θ value	0.00035302 (rank : 962)
Query Neighborhood Hits	1931	Target Neighborhood Hits	708	Shared Neighborhood Hits	659
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

BMX_HUMAN
NC score	0.678069 (rank : 635)	θ value	1.9326e-10 (rank : 626)
Query Neighborhood Hits	1931	Target Neighborhood Hits	942	Shared Neighborhood Hits	811
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BMX_MOUSE
NC score	0.677485 (rank : 636)	θ value	1.133e-10 (rank : 619)
Query Neighborhood Hits	1931	Target Neighborhood Hits	912	Shared Neighborhood Hits	804
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

TIE2_HUMAN
NC score	0.677334 (rank : 637)	θ value	3.77169e-06 (rank : 848)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1192	Shared Neighborhood Hits	913
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

CSK_HUMAN
NC score	0.677312 (rank : 638)	θ value	5.26297e-08 (rank : 747)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	845
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

TIE2_MOUSE
NC score	0.676597 (rank : 639)	θ value	3.77169e-06 (rank : 849)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1204	Shared Neighborhood Hits	910
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

ITK_MOUSE
NC score	0.676346 (rank : 640)	θ value	9.59137e-10 (rank : 656)
Query Neighborhood Hits	1931	Target Neighborhood Hits	985	Shared Neighborhood Hits	843
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.676256 (rank : 641)	θ value	2.36244e-08 (rank : 729)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1016	Shared Neighborhood Hits	846
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MATK_MOUSE
NC score	0.676143 (rank : 642)	θ value	3.08544e-08 (rank : 742)
Query Neighborhood Hits	1931	Target Neighborhood Hits	952	Shared Neighborhood Hits	835
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

BTK_HUMAN
NC score	0.675387 (rank : 643)	θ value	2.98157e-11 (rank : 600)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1026	Shared Neighborhood Hits	838
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

ABL2_HUMAN
NC score	0.675213 (rank : 644)	θ value	2.36244e-08 (rank : 725)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1045	Shared Neighborhood Hits	850
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

FRK_HUMAN
NC score	0.674862 (rank : 645)	θ value	1.47974e-10 (rank : 623)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1058	Shared Neighborhood Hits	852
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LRRK2_MOUSE
NC score	0.674567 (rank : 646)	θ value	1.33837e-11 (rank : 588)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1359	Shared Neighborhood Hits	848
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

BTK_MOUSE
NC score	0.674532 (rank : 647)	θ value	3.89403e-11 (rank : 604)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1017	Shared Neighborhood Hits	837
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

LYN_MOUSE
NC score	0.674277 (rank : 648)	θ value	2.13673e-09 (rank : 675)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1023	Shared Neighborhood Hits	857
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SRMS_MOUSE
NC score	0.674037 (rank : 649)	θ value	1.9326e-10 (rank : 631)
Query Neighborhood Hits	1931	Target Neighborhood Hits	964	Shared Neighborhood Hits	836
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

FAK2_MOUSE
NC score	0.673444 (rank : 650)	θ value	4.45536e-07 (rank : 799)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	807
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

LYN_HUMAN
NC score	0.673418 (rank : 651)	θ value	4.76016e-09 (rank : 699)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1022	Shared Neighborhood Hits	858
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MATK_HUMAN
NC score	0.672389 (rank : 652)	θ value	3.08544e-08 (rank : 741)
Query Neighborhood Hits	1931	Target Neighborhood Hits	954	Shared Neighborhood Hits	835
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

UFO_MOUSE
NC score	0.671996 (rank : 653)	θ value	0.00228821 (rank : 1007)
Query Neighborhood Hits	1931	Target Neighborhood Hits	988	Shared Neighborhood Hits	927
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

TXK_MOUSE
NC score	0.669935 (rank : 654)	θ value	3.89403e-11 (rank : 608)
Query Neighborhood Hits	1931	Target Neighborhood Hits	980	Shared Neighborhood Hits	820
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CDC7_HUMAN
NC score	0.669422 (rank : 655)	θ value	4.1701e-05 (rank : 906)
Query Neighborhood Hits	1931	Target Neighborhood Hits	652	Shared Neighborhood Hits	634
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

SRMS_HUMAN
NC score	0.669070 (rank : 656)	θ value	3.89403e-11 (rank : 607)
Query Neighborhood Hits	1931	Target Neighborhood Hits	946	Shared Neighborhood Hits	833
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FAK2_HUMAN
NC score	0.668713 (rank : 657)	θ value	9.92553e-07 (rank : 810)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	802
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

IRAK1_HUMAN
NC score	0.667991 (rank : 658)	θ value	0.00390308 (rank : 1021)
Query Neighborhood Hits	1931	Target Neighborhood Hits	820	Shared Neighborhood Hits	770
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TNK1_MOUSE
NC score	0.667632 (rank : 659)	θ value	8.97725e-08 (rank : 763)
Query Neighborhood Hits	1931	Target Neighborhood Hits	806	Shared Neighborhood Hits	786
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TIE1_MOUSE
NC score	0.667524 (rank : 660)	θ value	0.000270298 (rank : 955)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1266	Shared Neighborhood Hits	949
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

CDC7_MOUSE
NC score	0.666341 (rank : 661)	θ value	1.43324e-05 (rank : 873)
Query Neighborhood Hits	1931	Target Neighborhood Hits	641	Shared Neighborhood Hits	631
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

ROR2_MOUSE
NC score	0.665218 (rank : 662)	θ value	8.11959e-09 (rank : 709)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1000	Shared Neighborhood Hits	946
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

LCK_MOUSE
NC score	0.665014 (rank : 663)	θ value	2.36244e-08 (rank : 731)
Query Neighborhood Hits	1931	Target Neighborhood Hits	981	Shared Neighborhood Hits	837
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

UFO_HUMAN
NC score	0.665010 (rank : 664)	θ value	0.00509761 (rank : 1037)
Query Neighborhood Hits	1931	Target Neighborhood Hits	981	Shared Neighborhood Hits	921
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

EPHA5_MOUSE
NC score	0.664993 (rank : 665)	θ value	2.44474e-05 (rank : 894)
Query Neighborhood Hits	1931	Target Neighborhood Hits	950	Shared Neighborhood Hits	885
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

IRAK1_MOUSE
NC score	0.663974 (rank : 666)	θ value	0.0330416 (rank : 1097)
Query Neighborhood Hits	1931	Target Neighborhood Hits	784	Shared Neighborhood Hits	753
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

MERTK_MOUSE
NC score	0.663804 (rank : 667)	θ value	0.00869519 (rank : 1050)
Query Neighborhood Hits	1931	Target Neighborhood Hits	974	Shared Neighborhood Hits	935
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

EPHB1_HUMAN
NC score	0.661890 (rank : 668)	θ value	3.41135e-07 (rank : 792)
Query Neighborhood Hits	1931	Target Neighborhood Hits	988	Shared Neighborhood Hits	887
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

TIE1_HUMAN
NC score	0.661816 (rank : 669)	θ value	0.000786445 (rank : 981)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1241	Shared Neighborhood Hits	934
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHA7_MOUSE
NC score	0.660494 (rank : 670)	θ value	1.99992e-07 (rank : 776)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1025	Shared Neighborhood Hits	899
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA7_HUMAN
NC score	0.660460 (rank : 671)	θ value	1.99992e-07 (rank : 775)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1053	Shared Neighborhood Hits	902
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA3_HUMAN
NC score	0.660017 (rank : 672)	θ value	3.19293e-05 (rank : 900)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1005	Shared Neighborhood Hits	904
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

LCK_HUMAN
NC score	0.659834 (rank : 673)	θ value	7.59969e-07 (rank : 805)
Query Neighborhood Hits	1931	Target Neighborhood Hits	987	Shared Neighborhood Hits	841
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

MERTK_HUMAN
NC score	0.659745 (rank : 674)	θ value	0.0431538 (rank : 1121)
Query Neighborhood Hits	1931	Target Neighborhood Hits	988	Shared Neighborhood Hits	953
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

BLK_HUMAN
NC score	0.659571 (rank : 675)	θ value	1.53129e-07 (rank : 769)
Query Neighborhood Hits	1931	Target Neighborhood Hits	994	Shared Neighborhood Hits	842
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_HUMAN
NC score	0.659171 (rank : 676)	θ value	3.08544e-08 (rank : 736)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1035	Shared Neighborhood Hits	848
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

KS6C1_MOUSE
NC score	0.659019 (rank : 677)	θ value	0.0148317 (rank : 1064)
Query Neighborhood Hits	1931	Target Neighborhood Hits	700	Shared Neighborhood Hits	637
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

TNK1_HUMAN
NC score	0.658674 (rank : 678)	θ value	2.61198e-07 (rank : 787)
Query Neighborhood Hits	1931	Target Neighborhood Hits	815	Shared Neighborhood Hits	788
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

FYN_HUMAN
NC score	0.658362 (rank : 679)	θ value	1.69304e-06 (rank : 826)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1078	Shared Neighborhood Hits	852
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

BLK_MOUSE
NC score	0.657990 (rank : 680)	θ value	7.59969e-07 (rank : 803)
Query Neighborhood Hits	1931	Target Neighborhood Hits	992	Shared Neighborhood Hits	842
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PGFRA_HUMAN
NC score	0.657254 (rank : 681)	θ value	7.59969e-07 (rank : 808)
Query Neighborhood Hits	1931	Target Neighborhood Hits	980	Shared Neighborhood Hits	950
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

RET_HUMAN
NC score	0.656613 (rank : 682)	θ value	2.36244e-08 (rank : 732)
Query Neighborhood Hits	1931	Target Neighborhood Hits	873	Shared Neighborhood Hits	804
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ACK1_HUMAN
NC score	0.656145 (rank : 683)	θ value	3.64472e-09 (rank : 685)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1140	Shared Neighborhood Hits	925
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

KS6C1_HUMAN
NC score	0.655590 (rank : 684)	θ value	0.0330416 (rank : 1100)
Query Neighborhood Hits	1931	Target Neighborhood Hits	682	Shared Neighborhood Hits	640
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

ROS_HUMAN
NC score	0.655553 (rank : 685)	θ value	4.1701e-05 (rank : 910)
Query Neighborhood Hits	1931	Target Neighborhood Hits	907	Shared Neighborhood Hits	844
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

EPHB4_MOUSE
NC score	0.655524 (rank : 686)	θ value	1.29631e-06 (rank : 815)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1013	Shared Neighborhood Hits	891
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

RET_MOUSE
NC score	0.655275 (rank : 687)	θ value	6.87365e-08 (rank : 755)
Query Neighborhood Hits	1931	Target Neighborhood Hits	884	Shared Neighborhood Hits	806
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

HCK_MOUSE
NC score	0.655090 (rank : 688)	θ value	5.26297e-08 (rank : 750)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1029	Shared Neighborhood Hits	848
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

PGFRA_MOUSE
NC score	0.654964 (rank : 689)	θ value	7.59969e-07 (rank : 809)
Query Neighborhood Hits	1931	Target Neighborhood Hits	975	Shared Neighborhood Hits	952
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

ACK1_MOUSE
NC score	0.654435 (rank : 690)	θ value	8.97725e-08 (rank : 758)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1080	Shared Neighborhood Hits	899
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

EPHA3_MOUSE
NC score	0.654192 (rank : 691)	θ value	9.29e-05 (rank : 930)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	913
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA5_HUMAN
NC score	0.654073 (rank : 692)	θ value	1.87187e-05 (rank : 885)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1009	Shared Neighborhood Hits	901
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

FYN_MOUSE
NC score	0.653964 (rank : 693)	θ value	7.59969e-07 (rank : 804)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1073	Shared Neighborhood Hits	854
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SRC_MOUSE
NC score	0.653904 (rank : 694)	θ value	6.21693e-09 (rank : 704)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1033	Shared Neighborhood Hits	844
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRC_HUMAN
NC score	0.653576 (rank : 695)	θ value	2.13673e-09 (rank : 676)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1058	Shared Neighborhood Hits	847
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

TTBK1_HUMAN
NC score	0.652842 (rank : 696)	θ value	0.0736092 (rank : 1162)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1058	Shared Neighborhood Hits	781
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

EPHB4_HUMAN
NC score	0.651641 (rank : 697)	θ value	2.88788e-06 (rank : 841)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1056	Shared Neighborhood Hits	896
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

YES_HUMAN
NC score	0.649499 (rank : 698)	θ value	6.87365e-08 (rank : 757)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1059	Shared Neighborhood Hits	847
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

EPHA2_HUMAN
NC score	0.649284 (rank : 699)	θ value	2.44474e-05 (rank : 893)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1021	Shared Neighborhood Hits	888
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA4_MOUSE
NC score	0.649077 (rank : 700)	θ value	8.40245e-06 (rank : 865)
Query Neighborhood Hits	1931	Target Neighborhood Hits	982	Shared Neighborhood Hits	890
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

ERBB4_HUMAN
NC score	0.649039 (rank : 701)	θ value	1.25267e-09 (rank : 663)
Query Neighborhood Hits	1931	Target Neighborhood Hits	910	Shared Neighborhood Hits	817
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

YES_MOUSE
NC score	0.648926 (rank : 702)	θ value	5.26297e-08 (rank : 752)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1052	Shared Neighborhood Hits	844
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

EPHA8_HUMAN
NC score	0.648897 (rank : 703)	θ value	1.87187e-05 (rank : 886)
Query Neighborhood Hits	1931	Target Neighborhood Hits	956	Shared Neighborhood Hits	891
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA4_HUMAN
NC score	0.648130 (rank : 704)	θ value	8.40245e-06 (rank : 864)
Query Neighborhood Hits	1931	Target Neighborhood Hits	975	Shared Neighborhood Hits	889
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EGFR_MOUSE
NC score	0.648110 (rank : 705)	θ value	5.26297e-08 (rank : 748)
Query Neighborhood Hits	1931	Target Neighborhood Hits	927	Shared Neighborhood Hits	827
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

NTRK1_HUMAN
NC score	0.647485 (rank : 706)	θ value	0.000786445 (rank : 979)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1023	Shared Neighborhood Hits	896
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

EGFR_HUMAN
NC score	0.647467 (rank : 707)	θ value	2.61198e-07 (rank : 781)
Query Neighborhood Hits	1931	Target Neighborhood Hits	939	Shared Neighborhood Hits	820
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EPHB2_MOUSE
NC score	0.646890 (rank : 708)	θ value	2.88788e-06 (rank : 840)
Query Neighborhood Hits	1931	Target Neighborhood Hits	982	Shared Neighborhood Hits	880
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.646690 (rank : 709)	θ value	2.88788e-06 (rank : 839)
Query Neighborhood Hits	1931	Target Neighborhood Hits	983	Shared Neighborhood Hits	880
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

PGFRB_MOUSE
NC score	0.646326 (rank : 710)	θ value	2.21117e-06 (rank : 836)
Query Neighborhood Hits	1931	Target Neighborhood Hits	960	Shared Neighborhood Hits	938
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

EPHA8_MOUSE
NC score	0.646267 (rank : 711)	θ value	1.69304e-06 (rank : 824)
Query Neighborhood Hits	1931	Target Neighborhood Hits	969	Shared Neighborhood Hits	890
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA2_MOUSE
NC score	0.646223 (rank : 712)	θ value	1.43324e-05 (rank : 874)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1020	Shared Neighborhood Hits	885
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

FGR_HUMAN
NC score	0.644185 (rank : 713)	θ value	1.17247e-07 (rank : 764)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1067	Shared Neighborhood Hits	848
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

STYK1_HUMAN
NC score	0.643756 (rank : 714)	θ value	0.000158464 (rank : 943)
Query Neighborhood Hits	1931	Target Neighborhood Hits	786	Shared Neighborhood Hits	776
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

PGFRB_HUMAN
NC score	0.642454 (rank : 715)	θ value	8.40245e-06 (rank : 868)
Query Neighborhood Hits	1931	Target Neighborhood Hits	962	Shared Neighborhood Hits	942
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

EPHB3_HUMAN
NC score	0.642451 (rank : 716)	θ value	4.92598e-06 (rank : 852)
Query Neighborhood Hits	1931	Target Neighborhood Hits	996	Shared Neighborhood Hits	897
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
NC score	0.641582 (rank : 717)	θ value	4.92598e-06 (rank : 853)
Query Neighborhood Hits	1931	Target Neighborhood Hits	996	Shared Neighborhood Hits	896
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

TTBK2_HUMAN
NC score	0.641419 (rank : 718)	θ value	0.0736092 (rank : 1163)
Query Neighborhood Hits	1931	Target Neighborhood Hits	822	Shared Neighborhood Hits	721
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

FGR_MOUSE
NC score	0.640921 (rank : 719)	θ value	2.79066e-09 (rank : 684)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1069	Shared Neighborhood Hits	849
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ERBB2_MOUSE
NC score	0.639041 (rank : 720)	θ value	1.99992e-07 (rank : 777)
Query Neighborhood Hits	1931	Target Neighborhood Hits	918	Shared Neighborhood Hits	824
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

TNI3K_MOUSE
NC score	0.638889 (rank : 721)	θ value	0.000461057 (rank : 968)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1079	Shared Neighborhood Hits	796
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TTBK2_MOUSE
NC score	0.638626 (rank : 722)	θ value	0.0736092 (rank : 1164)
Query Neighborhood Hits	1931	Target Neighborhood Hits	811	Shared Neighborhood Hits	713
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

RON_HUMAN
NC score	0.637978 (rank : 723)	θ value	8.97725e-08 (rank : 762)
Query Neighborhood Hits	1931	Target Neighborhood Hits	842	Shared Neighborhood Hits	807
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ERBB2_HUMAN
NC score	0.636966 (rank : 724)	θ value	8.97725e-08 (rank : 759)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1073	Shared Neighborhood Hits	879
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

EPHA1_HUMAN
NC score	0.636491 (rank : 725)	θ value	1.80886e-08 (rank : 720)
Query Neighborhood Hits	1931	Target Neighborhood Hits	997	Shared Neighborhood Hits	862
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

KIT_HUMAN
NC score	0.636419 (rank : 726)	θ value	3.19293e-05 (rank : 902)
Query Neighborhood Hits	1931	Target Neighborhood Hits	953	Shared Neighborhood Hits	931
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
NC score	0.635785 (rank : 727)	θ value	0.00020696 (rank : 946)
Query Neighborhood Hits	1931	Target Neighborhood Hits	949	Shared Neighborhood Hits	937
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KC1A_HUMAN
NC score	0.634679 (rank : 728)	θ value	0.21417 (rank : 1232)
Query Neighborhood Hits	1931	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.634679 (rank : 729)	θ value	0.21417 (rank : 1233)
Query Neighborhood Hits	1931	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

INSR_HUMAN
NC score	0.633622 (rank : 730)	θ value	3.41135e-07 (rank : 795)
Query Neighborhood Hits	1931	Target Neighborhood Hits	963	Shared Neighborhood Hits	853
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
NC score	0.633142 (rank : 731)	θ value	2.61198e-07 (rank : 782)
Query Neighborhood Hits	1931	Target Neighborhood Hits	968	Shared Neighborhood Hits	846
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

MET_MOUSE
NC score	0.632667 (rank : 732)	θ value	8.40245e-06 (rank : 866)
Query Neighborhood Hits	1931	Target Neighborhood Hits	844	Shared Neighborhood Hits	800
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

TNI3K_HUMAN
NC score	0.632150 (rank : 733)	θ value	7.1131e-05 (rank : 926)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1084	Shared Neighborhood Hits	803
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

KC1AL_HUMAN
NC score	0.630946 (rank : 734)	θ value	0.279714 (rank : 1254)
Query Neighborhood Hits	1931	Target Neighborhood Hits	734	Shared Neighborhood Hits	728
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

MET_HUMAN
NC score	0.630622 (rank : 735)	θ value	1.09739e-05 (rank : 872)
Query Neighborhood Hits	1931	Target Neighborhood Hits	831	Shared Neighborhood Hits	796
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

KC1D_HUMAN
NC score	0.629613 (rank : 736)	θ value	0.0563607 (rank : 1134)
Query Neighborhood Hits	1931	Target Neighborhood Hits	737	Shared Neighborhood Hits	727
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.629609 (rank : 737)	θ value	0.0563607 (rank : 1135)
Query Neighborhood Hits	1931	Target Neighborhood Hits	737	Shared Neighborhood Hits	727
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

STYK1_MOUSE
NC score	0.629219 (rank : 738)	θ value	4.1701e-05 (rank : 911)
Query Neighborhood Hits	1931	Target Neighborhood Hits	779	Shared Neighborhood Hits	771
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

DDR2_MOUSE
NC score	0.629217 (rank : 739)	θ value	2.36244e-08 (rank : 726)
Query Neighborhood Hits	1931	Target Neighborhood Hits	813	Shared Neighborhood Hits	779
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

AATK_HUMAN
NC score	0.627987 (rank : 740)	θ value	4.1701e-05 (rank : 905)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1243	Shared Neighborhood Hits	927
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

EPHA1_MOUSE
NC score	0.627567 (rank : 741)	θ value	3.41135e-07 (rank : 791)
Query Neighborhood Hits	1931	Target Neighborhood Hits	958	Shared Neighborhood Hits	854
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

RON_MOUSE
NC score	0.627036 (rank : 742)	θ value	2.21117e-06 (rank : 837)
Query Neighborhood Hits	1931	Target Neighborhood Hits	836	Shared Neighborhood Hits	799
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

KC1E_HUMAN
NC score	0.626431 (rank : 743)	θ value	0.0563607 (rank : 1136)
Query Neighborhood Hits	1931	Target Neighborhood Hits	732	Shared Neighborhood Hits	724
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
NC score	0.626421 (rank : 744)	θ value	0.0563607 (rank : 1137)
Query Neighborhood Hits	1931	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

CSF1R_MOUSE
NC score	0.625826 (rank : 745)	θ value	0.0252991 (rank : 1080)
Query Neighborhood Hits	1931	Target Neighborhood Hits	983	Shared Neighborhood Hits	963
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

DDR2_HUMAN
NC score	0.623566 (rank : 746)	θ value	3.41135e-07 (rank : 789)
Query Neighborhood Hits	1931	Target Neighborhood Hits	818	Shared Neighborhood Hits	779
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

KC1G1_MOUSE
NC score	0.623286 (rank : 747)	θ value	0.0113563 (rank : 1056)
Query Neighborhood Hits	1931	Target Neighborhood Hits	713	Shared Neighborhood Hits	706
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

AVR2A_MOUSE
NC score	0.621561 (rank : 748)	θ value	0.0252991 (rank : 1078)
Query Neighborhood Hits	1931	Target Neighborhood Hits	767	Shared Neighborhood Hits	763
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.621547 (rank : 749)	θ value	0.0252991 (rank : 1077)
Query Neighborhood Hits	1931	Target Neighborhood Hits	767	Shared Neighborhood Hits	763
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

KC1G1_HUMAN
NC score	0.621452 (rank : 750)	θ value	0.0113563 (rank : 1055)
Query Neighborhood Hits	1931	Target Neighborhood Hits	708	Shared Neighborhood Hits	704
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

MLKL_MOUSE
NC score	0.620066 (rank : 751)	θ value	0.00509761 (rank : 1032)
Query Neighborhood Hits	1931	Target Neighborhood Hits	707	Shared Neighborhood Hits	696
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

INSRR_MOUSE
NC score	0.619485 (rank : 752)	θ value	2.88788e-06 (rank : 844)
Query Neighborhood Hits	1931	Target Neighborhood Hits	961	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KC1G3_HUMAN
NC score	0.618638 (rank : 753)	θ value	0.00134147 (rank : 988)
Query Neighborhood Hits	1931	Target Neighborhood Hits	711	Shared Neighborhood Hits	707
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

TGFR2_MOUSE
NC score	0.617694 (rank : 754)	θ value	0.0193708 (rank : 1074)
Query Neighborhood Hits	1931	Target Neighborhood Hits	748	Shared Neighborhood Hits	744
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_HUMAN
NC score	0.617654 (rank : 755)	θ value	0.0193708 (rank : 1073)
Query Neighborhood Hits	1931	Target Neighborhood Hits	748	Shared Neighborhood Hits	743
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

IGF1R_MOUSE
NC score	0.617542 (rank : 756)	θ value	9.92553e-07 (rank : 811)
Query Neighborhood Hits	1931	Target Neighborhood Hits	973	Shared Neighborhood Hits	842
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

AATK_MOUSE
NC score	0.615902 (rank : 757)	θ value	0.000121331 (rank : 934)
Query Neighborhood Hits	1931	Target Neighborhood Hits	942	Shared Neighborhood Hits	819
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

INSRR_HUMAN
NC score	0.615900 (rank : 758)	θ value	5.44631e-05 (rank : 918)
Query Neighborhood Hits	1931	Target Neighborhood Hits	950	Shared Neighborhood Hits	831
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

IGF1R_HUMAN
NC score	0.615797 (rank : 759)	θ value	5.81887e-07 (rank : 802)
Query Neighborhood Hits	1931	Target Neighborhood Hits	977	Shared Neighborhood Hits	843
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ERBB3_MOUSE
NC score	0.613019 (rank : 760)	θ value	1.99992e-07 (rank : 778)
Query Neighborhood Hits	1931	Target Neighborhood Hits	898	Shared Neighborhood Hits	787
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

IRAK2_HUMAN
NC score	0.611014 (rank : 761)	θ value	θ > 10 (rank : 1996)
Query Neighborhood Hits	1931	Target Neighborhood Hits	714	Shared Neighborhood Hits	685
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ERBB3_HUMAN
NC score	0.610477 (rank : 762)	θ value	1.80886e-08 (rank : 721)
Query Neighborhood Hits	1931	Target Neighborhood Hits	918	Shared Neighborhood Hits	788
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

CSF1R_HUMAN
NC score	0.609199 (rank : 763)	θ value	0.00175202 (rank : 994)
Query Neighborhood Hits	1931	Target Neighborhood Hits	943	Shared Neighborhood Hits	926
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ACVR1_MOUSE
NC score	0.607356 (rank : 764)	θ value	0.0193708 (rank : 1069)
Query Neighborhood Hits	1931	Target Neighborhood Hits	768	Shared Neighborhood Hits	760
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

AVR2B_HUMAN
NC score	0.606371 (rank : 765)	θ value	0.0113563 (rank : 1052)
Query Neighborhood Hits	1931	Target Neighborhood Hits	748	Shared Neighborhood Hits	740
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
NC score	0.606340 (rank : 766)	θ value	0.0252991 (rank : 1079)
Query Neighborhood Hits	1931	Target Neighborhood Hits	749	Shared Neighborhood Hits	740
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

SCYL2_HUMAN
NC score	0.606232 (rank : 767)	θ value	8.40245e-06 (rank : 869)
Query Neighborhood Hits	1931	Target Neighborhood Hits	632	Shared Neighborhood Hits	569
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

FLT3_MOUSE
NC score	0.603436 (rank : 768)	θ value	5.44631e-05 (rank : 916)
Query Neighborhood Hits	1931	Target Neighborhood Hits	847	Shared Neighborhood Hits	842
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

ACVR1_HUMAN
NC score	0.601501 (rank : 769)	θ value	0.0193708 (rank : 1068)
Query Neighborhood Hits	1931	Target Neighborhood Hits	760	Shared Neighborhood Hits	754
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

DDR1_MOUSE
NC score	0.601145 (rank : 770)	θ value	8.40245e-06 (rank : 863)
Query Neighborhood Hits	1931	Target Neighborhood Hits	818	Shared Neighborhood Hits	775
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

FLT3_HUMAN
NC score	0.598661 (rank : 771)	θ value	5.44631e-05 (rank : 915)
Query Neighborhood Hits	1931	Target Neighborhood Hits	843	Shared Neighborhood Hits	834
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

DDR1_HUMAN
NC score	0.598233 (rank : 772)	θ value	0.00390308 (rank : 1015)
Query Neighborhood Hits	1931	Target Neighborhood Hits	819	Shared Neighborhood Hits	776
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

EPHA6_MOUSE
NC score	0.597786 (rank : 773)	θ value	5.44631e-05 (rank : 914)
Query Neighborhood Hits	1931	Target Neighborhood Hits	946	Shared Neighborhood Hits	865
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_HUMAN
NC score	0.595943 (rank : 774)	θ value	0.000158464 (rank : 937)
Query Neighborhood Hits	1931	Target Neighborhood Hits	959	Shared Neighborhood Hits	867
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

KC1G2_MOUSE
NC score	0.595407 (rank : 775)	θ value	0.00035302 (rank : 959)
Query Neighborhood Hits	1931	Target Neighborhood Hits	695	Shared Neighborhood Hits	691
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_HUMAN
NC score	0.593688 (rank : 776)	θ value	0.000602161 (rank : 973)
Query Neighborhood Hits	1931	Target Neighborhood Hits	693	Shared Neighborhood Hits	691
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

BMR1A_HUMAN
NC score	0.593574 (rank : 777)	θ value	8.99809 (rank : 1826)
Query Neighborhood Hits	1931	Target Neighborhood Hits	759	Shared Neighborhood Hits	749
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
NC score	0.593065 (rank : 778)	θ value	1.81305 (rank : 1484)
Query Neighborhood Hits	1931	Target Neighborhood Hits	758	Shared Neighborhood Hits	749
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

ALK_HUMAN
NC score	0.592724 (rank : 779)	θ value	0.0431538 (rank : 1111)
Query Neighborhood Hits	1931	Target Neighborhood Hits	795	Shared Neighborhood Hits	742
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LTK_MOUSE
NC score	0.591703 (rank : 780)	θ value	0.00228821 (rank : 1002)
Query Neighborhood Hits	1931	Target Neighborhood Hits	770	Shared Neighborhood Hits	753
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

ALK_MOUSE
NC score	0.590788 (rank : 781)	θ value	0.0252991 (rank : 1076)
Query Neighborhood Hits	1931	Target Neighborhood Hits	811	Shared Neighborhood Hits	757
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

TOPK_MOUSE
NC score	0.587958 (rank : 782)	θ value	4.1701e-05 (rank : 913)
Query Neighborhood Hits	1931	Target Neighborhood Hits	618	Shared Neighborhood Hits	608
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

SCYL2_MOUSE
NC score	0.585297 (rank : 783)	θ value	7.1131e-05 (rank : 924)
Query Neighborhood Hits	1931	Target Neighborhood Hits	603	Shared Neighborhood Hits	549
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

LTK_HUMAN
NC score	0.584618 (rank : 784)	θ value	0.00390308 (rank : 1022)
Query Neighborhood Hits	1931	Target Neighborhood Hits	774	Shared Neighborhood Hits	756
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

TGFR1_HUMAN
NC score	0.583266 (rank : 785)	θ value	6.88961 (rank : 1804)
Query Neighborhood Hits	1931	Target Neighborhood Hits	755	Shared Neighborhood Hits	748
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.582948 (rank : 786)	θ value	6.88961 (rank : 1805)
Query Neighborhood Hits	1931	Target Neighborhood Hits	753	Shared Neighborhood Hits	748
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TOPK_HUMAN
NC score	0.582364 (rank : 787)	θ value	1.29631e-06 (rank : 820)
Query Neighborhood Hits	1931	Target Neighborhood Hits	605	Shared Neighborhood Hits	596
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

ANKK1_MOUSE
NC score	0.582341 (rank : 788)	θ value	9.29e-05 (rank : 927)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1072	Shared Neighborhood Hits	799
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ACV1B_MOUSE
NC score	0.582188 (rank : 789)	θ value	0.365318 (rank : 1266)
Query Neighborhood Hits	1931	Target Neighborhood Hits	753	Shared Neighborhood Hits	749
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.582081 (rank : 790)	θ value	0.365318 (rank : 1265)
Query Neighborhood Hits	1931	Target Neighborhood Hits	753	Shared Neighborhood Hits	750
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

BMR1B_MOUSE
NC score	0.581935 (rank : 791)	θ value	1.06291 (rank : 1399)
Query Neighborhood Hits	1931	Target Neighborhood Hits	758	Shared Neighborhood Hits	750
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMR1B_HUMAN
NC score	0.580304 (rank : 792)	θ value	1.06291 (rank : 1398)
Query Neighborhood Hits	1931	Target Neighborhood Hits	760	Shared Neighborhood Hits	749
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

IRAK3_MOUSE
NC score	0.579531 (rank : 793)	θ value	0.0330416 (rank : 1098)
Query Neighborhood Hits	1931	Target Neighborhood Hits	628	Shared Neighborhood Hits	608
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IRAK3_HUMAN
NC score	0.578770 (rank : 794)	θ value	0.365318 (rank : 1281)
Query Neighborhood Hits	1931	Target Neighborhood Hits	644	Shared Neighborhood Hits	631
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RIPK4_HUMAN
NC score	0.573541 (rank : 795)	θ value	1.43324e-05 (rank : 880)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1094	Shared Neighborhood Hits	808
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANKK1_HUMAN
NC score	0.572339 (rank : 796)	θ value	7.1131e-05 (rank : 919)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1075	Shared Neighborhood Hits	795
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

BMPR2_HUMAN
NC score	0.570058 (rank : 797)	θ value	2.36792 (rank : 1525)
Query Neighborhood Hits	1931	Target Neighborhood Hits	736	Shared Neighborhood Hits	710
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
NC score	0.568756 (rank : 798)	θ value	2.36792 (rank : 1526)
Query Neighborhood Hits	1931	Target Neighborhood Hits	738	Shared Neighborhood Hits	710
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

ACVL1_MOUSE
NC score	0.563538 (rank : 799)	θ value	0.62314 (rank : 1327)
Query Neighborhood Hits	1931	Target Neighborhood Hits	739	Shared Neighborhood Hits	736
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

EPHB6_MOUSE
NC score	0.555744 (rank : 800)	θ value	0.0113563 (rank : 1053)
Query Neighborhood Hits	1931	Target Neighborhood Hits	906	Shared Neighborhood Hits	797
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

BUB1_MOUSE
NC score	0.548293 (rank : 801)	θ value	2.36792 (rank : 1527)
Query Neighborhood Hits	1931	Target Neighborhood Hits	583	Shared Neighborhood Hits	535
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

EPHAA_HUMAN
NC score	0.545240 (rank : 802)	θ value	0.0563607 (rank : 1130)
Query Neighborhood Hits	1931	Target Neighborhood Hits	960	Shared Neighborhood Hits	807
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

ACVL1_HUMAN
NC score	0.542725 (rank : 803)	θ value	0.813845 (rank : 1361)
Query Neighborhood Hits	1931	Target Neighborhood Hits	716	Shared Neighborhood Hits	711
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

EPHB6_HUMAN
NC score	0.542407 (rank : 804)	θ value	0.0563607 (rank : 1131)
Query Neighborhood Hits	1931	Target Neighborhood Hits	912	Shared Neighborhood Hits	783
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

RYK_MOUSE
NC score	0.535034 (rank : 805)	θ value	0.0563607 (rank : 1139)
Query Neighborhood Hits	1931	Target Neighborhood Hits	715	Shared Neighborhood Hits	703
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

MLKL_HUMAN
NC score	0.530819 (rank : 806)	θ value	0.0193708 (rank : 1071)
Query Neighborhood Hits	1931	Target Neighborhood Hits	600	Shared Neighborhood Hits	580
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ACV1C_MOUSE
NC score	0.526700 (rank : 807)	θ value	2.36792 (rank : 1521)
Query Neighborhood Hits	1931	Target Neighborhood Hits	715	Shared Neighborhood Hits	703
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_HUMAN
NC score	0.522918 (rank : 808)	θ value	4.03905 (rank : 1621)
Query Neighborhood Hits	1931	Target Neighborhood Hits	709	Shared Neighborhood Hits	697
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

RYK_HUMAN
NC score	0.521677 (rank : 809)	θ value	0.0563607 (rank : 1138)
Query Neighborhood Hits	1931	Target Neighborhood Hits	701	Shared Neighborhood Hits	692
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

SRPK1_MOUSE
NC score	0.518348 (rank : 810)	θ value	0.0330416 (rank : 1105)
Query Neighborhood Hits	1931	Target Neighborhood Hits	639	Shared Neighborhood Hits	566
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_HUMAN
NC score	0.517539 (rank : 811)	θ value	0.0252991 (rank : 1087)
Query Neighborhood Hits	1931	Target Neighborhood Hits	664	Shared Neighborhood Hits	573
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK1_HUMAN
NC score	0.516240 (rank : 812)	θ value	0.0252991 (rank : 1086)
Query Neighborhood Hits	1931	Target Neighborhood Hits	706	Shared Neighborhood Hits	589
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_MOUSE
NC score	0.514818 (rank : 813)	θ value	0.0252991 (rank : 1088)
Query Neighborhood Hits	1931	Target Neighborhood Hits	765	Shared Neighborhood Hits	584
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STK23_MOUSE
NC score	0.512986 (rank : 814)	θ value	0.21417 (rank : 1240)
Query Neighborhood Hits	1931	Target Neighborhood Hits	572	Shared Neighborhood Hits	558
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_HUMAN
NC score	0.512717 (rank : 815)	θ value	0.0736092 (rank : 1159)
Query Neighborhood Hits	1931	Target Neighborhood Hits	556	Shared Neighborhood Hits	552
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

GUC2F_HUMAN
NC score	0.506456 (rank : 816)	θ value	5.44631e-05 (rank : 917)
Query Neighborhood Hits	1931	Target Neighborhood Hits	740	Shared Neighborhood Hits	678
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

AMHR2_HUMAN
NC score	0.486967 (rank : 817)	θ value	0.163984 (rank : 1202)
Query Neighborhood Hits	1931	Target Neighborhood Hits	715	Shared Neighborhood Hits	668
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

OBSL1_HUMAN
NC score	0.473598 (rank : 818)	θ value	7.47326e-180 (rank : 3)
Query Neighborhood Hits	1931	Target Neighborhood Hits	354	Shared Neighborhood Hits	319
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

TEX14_MOUSE
NC score	0.466313 (rank : 819)	θ value	0.00298849 (rank : 1013)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1333	Shared Neighborhood Hits	682
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

GUC2D_HUMAN
NC score	0.463431 (rank : 820)	θ value	2.21117e-06 (rank : 833)
Query Neighborhood Hits	1931	Target Neighborhood Hits	715	Shared Neighborhood Hits	664
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

NRBP_HUMAN
NC score	0.461684 (rank : 821)	θ value	0.0252991 (rank : 1084)
Query Neighborhood Hits	1931	Target Neighborhood Hits	448	Shared Neighborhood Hits	423
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
NC score	0.459596 (rank : 822)	θ value	0.0113563 (rank : 1057)
Query Neighborhood Hits	1931	Target Neighborhood Hits	442	Shared Neighborhood Hits	419
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

GUC2C_HUMAN
NC score	0.456130 (rank : 823)	θ value	0.00869519 (rank : 1049)
Query Neighborhood Hits	1931	Target Neighborhood Hits	624	Shared Neighborhood Hits	585
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

VRK2_MOUSE
NC score	0.455632 (rank : 824)	θ value	0.125558 (rank : 1199)
Query Neighborhood Hits	1931	Target Neighborhood Hits	586	Shared Neighborhood Hits	574
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_MOUSE
NC score	0.452941 (rank : 825)	θ value	0.00665767 (rank : 1048)
Query Neighborhood Hits	1931	Target Neighborhood Hits	583	Shared Neighborhood Hits	575
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK2_HUMAN
NC score	0.451745 (rank : 826)	θ value	0.0193708 (rank : 1075)
Query Neighborhood Hits	1931	Target Neighborhood Hits	582	Shared Neighborhood Hits	562
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_HUMAN
NC score	0.447011 (rank : 827)	θ value	0.0431538 (rank : 1128)
Query Neighborhood Hits	1931	Target Neighborhood Hits	584	Shared Neighborhood Hits	574
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

ANPRB_HUMAN
NC score	0.446936 (rank : 828)	θ value	0.000602161 (rank : 970)
Query Neighborhood Hits	1931	Target Neighborhood Hits	646	Shared Neighborhood Hits	585
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2E_MOUSE
NC score	0.442156 (rank : 829)	θ value	2.88788e-06 (rank : 843)
Query Neighborhood Hits	1931	Target Neighborhood Hits	692	Shared Neighborhood Hits	640
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

ROBO3_HUMAN
NC score	0.434910 (rank : 830)	θ value	2.96777e-27 (rank : 92)
Query Neighborhood Hits	1931	Target Neighborhood Hits	570	Shared Neighborhood Hits	428
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

NCAM2_MOUSE
NC score	0.434466 (rank : 831)	θ value	2.77775e-25 (rank : 128)
Query Neighborhood Hits	1931	Target Neighborhood Hits	472	Shared Neighborhood Hits	398
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

ROBO1_HUMAN
NC score	0.433626 (rank : 832)	θ value	2.77131e-33 (rank : 41)
Query Neighborhood Hits	1931	Target Neighborhood Hits	529	Shared Neighborhood Hits	392
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO1_MOUSE
NC score	0.433438 (rank : 833)	θ value	4.72714e-33 (rank : 44)
Query Neighborhood Hits	1931	Target Neighborhood Hits	559	Shared Neighborhood Hits	403
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

GUC2G_MOUSE
NC score	0.432372 (rank : 834)	θ value	θ > 10 (rank : 1982)
Query Neighborhood Hits	1931	Target Neighborhood Hits	644	Shared Neighborhood Hits	585
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

NCAM2_HUMAN
NC score	0.432358 (rank : 835)	θ value	4.43474e-23 (rank : 172)
Query Neighborhood Hits	1931	Target Neighborhood Hits	441	Shared Neighborhood Hits	387
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

ROBO2_MOUSE
NC score	0.431998 (rank : 836)	θ value	1.0531e-32 (rank : 45)
Query Neighborhood Hits	1931	Target Neighborhood Hits	504	Shared Neighborhood Hits	393
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_HUMAN
NC score	0.431982 (rank : 837)	θ value	1.6247e-33 (rank : 39)
Query Neighborhood Hits	1931	Target Neighborhood Hits	479	Shared Neighborhood Hits	380
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_MOUSE
NC score	0.430403 (rank : 838)	θ value	1.80048e-24 (rank : 145)
Query Neighborhood Hits	1931	Target Neighborhood Hits	524	Shared Neighborhood Hits	408
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

TEX14_HUMAN
NC score	0.429381 (rank : 839)	θ value	0.00228821 (rank : 1006)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1103	Shared Neighborhood Hits	620
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

DSCL1_HUMAN
NC score	0.428303 (rank : 840)	θ value	2.35151e-24 (rank : 146)
Query Neighborhood Hits	1931	Target Neighborhood Hits	589	Shared Neighborhood Hits	449
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DSCAM_HUMAN
NC score	0.425762 (rank : 841)	θ value	9.87957e-23 (rank : 180)
Query Neighborhood Hits	1931	Target Neighborhood Hits	524	Shared Neighborhood Hits	404
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

NCA12_HUMAN
NC score	0.423594 (rank : 842)	θ value	7.82807e-20 (rank : 264)
Query Neighborhood Hits	1931	Target Neighborhood Hits	437	Shared Neighborhood Hits	372
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

MYPN_HUMAN
NC score	0.423325 (rank : 843)	θ value	6.18819e-25 (rank : 137)
Query Neighborhood Hits	1931	Target Neighborhood Hits	418	Shared Neighborhood Hits	320
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

NCA11_HUMAN
NC score	0.422372 (rank : 844)	θ value	7.82807e-20 (rank : 263)
Query Neighborhood Hits	1931	Target Neighborhood Hits	443	Shared Neighborhood Hits	375
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

PUNC_MOUSE
NC score	0.421522 (rank : 845)	θ value	8.65492e-19 (rank : 295)
Query Neighborhood Hits	1931	Target Neighborhood Hits	501	Shared Neighborhood Hits	374
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ANPRB_MOUSE
NC score	0.421021 (rank : 846)	θ value	0.000270298 (rank : 949)
Query Neighborhood Hits	1931	Target Neighborhood Hits	607	Shared Neighborhood Hits	560
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

PUNC_HUMAN
NC score	0.420611 (rank : 847)	θ value	5.60996e-18 (rank : 332)
Query Neighborhood Hits	1931	Target Neighborhood Hits	449	Shared Neighborhood Hits	345
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

MYPN_MOUSE
NC score	0.420469 (rank : 848)	θ value	2.35151e-24 (rank : 149)
Query Neighborhood Hits	1931	Target Neighborhood Hits	421	Shared Neighborhood Hits	319
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NCA12_MOUSE
NC score	0.420051 (rank : 849)	θ value	1.92812e-18 (rank : 307)
Query Neighborhood Hits	1931	Target Neighborhood Hits	399	Shared Neighborhood Hits	364
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

BOC_MOUSE
NC score	0.419489 (rank : 850)	θ value	5.8054e-15 (rank : 436)
Query Neighborhood Hits	1931	Target Neighborhood Hits	433	Shared Neighborhood Hits	354
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BOC_HUMAN
NC score	0.419108 (rank : 851)	θ value	4.44505e-15 (rank : 433)
Query Neighborhood Hits	1931	Target Neighborhood Hits	543	Shared Neighborhood Hits	401
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

MYOTI_HUMAN
NC score	0.418722 (rank : 852)	θ value	2.5182e-18 (rank : 317)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	275
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
NC score	0.418548 (rank : 853)	θ value	3.28887e-18 (rank : 324)
Query Neighborhood Hits	1931	Target Neighborhood Hits	297	Shared Neighborhood Hits	273
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

FGRL1_HUMAN
NC score	0.417877 (rank : 854)	θ value	3.51386e-20 (rank : 247)
Query Neighborhood Hits	1931	Target Neighborhood Hits	335	Shared Neighborhood Hits	297
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

NCA11_MOUSE
NC score	0.416352 (rank : 855)	θ value	1.92812e-18 (rank : 306)
Query Neighborhood Hits	1931	Target Neighborhood Hits	661	Shared Neighborhood Hits	447
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

FGRL1_MOUSE
NC score	0.415377 (rank : 856)	θ value	1.47631e-18 (rank : 300)
Query Neighborhood Hits	1931	Target Neighborhood Hits	325	Shared Neighborhood Hits	302
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

CDON_HUMAN
NC score	0.414132 (rank : 857)	θ value	2.13179e-17 (rank : 347)
Query Neighborhood Hits	1931	Target Neighborhood Hits	412	Shared Neighborhood Hits	331
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CDON_MOUSE
NC score	0.414125 (rank : 858)	θ value	1.63225e-17 (rank : 344)
Query Neighborhood Hits	1931	Target Neighborhood Hits	410	Shared Neighborhood Hits	346
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

NFASC_MOUSE
NC score	0.412873 (rank : 859)	θ value	4.15078e-21 (rank : 221)
Query Neighborhood Hits	1931	Target Neighborhood Hits	475	Shared Neighborhood Hits	388
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

ANPRA_HUMAN
NC score	0.412141 (rank : 860)	θ value	0.279714 (rank : 1243)
Query Neighborhood Hits	1931	Target Neighborhood Hits	612	Shared Neighborhood Hits	548
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

DCC_HUMAN
NC score	0.412137 (rank : 861)	θ value	2.5182e-18 (rank : 313)
Query Neighborhood Hits	1931	Target Neighborhood Hits	583	Shared Neighborhood Hits	423
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
NC score	0.411427 (rank : 862)	θ value	9.24701e-21 (rank : 230)
Query Neighborhood Hits	1931	Target Neighborhood Hits	896	Shared Neighborhood Hits	544
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

NEO1_HUMAN
NC score	0.411143 (rank : 863)	θ value	8.65492e-19 (rank : 294)
Query Neighborhood Hits	1931	Target Neighborhood Hits	530	Shared Neighborhood Hits	386
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

ANPRA_MOUSE
NC score	0.410715 (rank : 864)	θ value	0.0961366 (rank : 1165)
Query Neighborhood Hits	1931	Target Neighborhood Hits	600	Shared Neighborhood Hits	539
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

NFASC_HUMAN
NC score	0.410466 (rank : 865)	θ value	3.17815e-21 (rank : 217)
Query Neighborhood Hits	1931	Target Neighborhood Hits	497	Shared Neighborhood Hits	394
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NEO1_MOUSE
NC score	0.409844 (rank : 866)	θ value	2.97466e-19 (rank : 280)
Query Neighborhood Hits	1931	Target Neighborhood Hits	523	Shared Neighborhood Hits	388
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

CNTN5_HUMAN
NC score	0.409519 (rank : 867)	θ value	1.80048e-24 (rank : 142)
Query Neighborhood Hits	1931	Target Neighborhood Hits	446	Shared Neighborhood Hits	383
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

SDK1_HUMAN
NC score	0.407821 (rank : 868)	θ value	3.62785e-25 (rank : 130)
Query Neighborhood Hits	1931	Target Neighborhood Hits	511	Shared Neighborhood Hits	390
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

CNTN2_HUMAN
NC score	0.407616 (rank : 869)	θ value	2.5182e-18 (rank : 312)
Query Neighborhood Hits	1931	Target Neighborhood Hits	440	Shared Neighborhood Hits	386
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
NC score	0.407597 (rank : 870)	θ value	1.13037e-18 (rank : 298)
Query Neighborhood Hits	1931	Target Neighborhood Hits	450	Shared Neighborhood Hits	392
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN4_MOUSE
NC score	0.407443 (rank : 871)	θ value	1.33526e-19 (rank : 271)
Query Neighborhood Hits	1931	Target Neighborhood Hits	445	Shared Neighborhood Hits	383
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

CNTN4_HUMAN
NC score	0.407376 (rank : 872)	θ value	4.58923e-20 (rank : 253)
Query Neighborhood Hits	1931	Target Neighborhood Hits	449	Shared Neighborhood Hits	386
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

ILK1_HUMAN
NC score	0.405765 (rank : 873)	θ value	0.0961366 (rank : 1171)
Query Neighborhood Hits	1931	Target Neighborhood Hits	857	Shared Neighborhood Hits	593
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

SDK1_MOUSE
NC score	0.405627 (rank : 874)	θ value	1.12775e-26 (rank : 107)
Query Neighborhood Hits	1931	Target Neighborhood Hits	495	Shared Neighborhood Hits	382
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

CNTN5_MOUSE
NC score	0.405567 (rank : 875)	θ value	3.17815e-21 (rank : 215)
Query Neighborhood Hits	1931	Target Neighborhood Hits	434	Shared Neighborhood Hits	374
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

SDK2_HUMAN
NC score	0.403845 (rank : 876)	θ value	1.02238e-19 (rank : 270)
Query Neighborhood Hits	1931	Target Neighborhood Hits	495	Shared Neighborhood Hits	387
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

ILK_MOUSE
NC score	0.403818 (rank : 877)	θ value	0.0961366 (rank : 1172)
Query Neighborhood Hits	1931	Target Neighborhood Hits	858	Shared Neighborhood Hits	594
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

NRCAM_MOUSE
NC score	0.402771 (rank : 878)	θ value	1.33526e-19 (rank : 273)
Query Neighborhood Hits	1931	Target Neighborhood Hits	432	Shared Neighborhood Hits	351
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

L1CAM_MOUSE
NC score	0.402759 (rank : 879)	θ value	2.60593e-15 (rank : 427)
Query Neighborhood Hits	1931	Target Neighborhood Hits	457	Shared Neighborhood Hits	375
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_HUMAN
NC score	0.402443 (rank : 880)	θ value	1.38178e-16 (rank : 387)
Query Neighborhood Hits	1931	Target Neighborhood Hits	457	Shared Neighborhood Hits	379
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CNTN3_HUMAN
NC score	0.402007 (rank : 881)	θ value	1.63225e-17 (rank : 345)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	375
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

NRCAM_HUMAN
NC score	0.401867 (rank : 882)	θ value	3.75424e-22 (rank : 195)
Query Neighborhood Hits	1931	Target Neighborhood Hits	439	Shared Neighborhood Hits	368
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

CNTN6_MOUSE
NC score	0.401856 (rank : 883)	θ value	1.38178e-16 (rank : 385)
Query Neighborhood Hits	1931	Target Neighborhood Hits	429	Shared Neighborhood Hits	367
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

SDK2_MOUSE
NC score	0.401732 (rank : 884)	θ value	4.15078e-21 (rank : 222)
Query Neighborhood Hits	1931	Target Neighborhood Hits	480	Shared Neighborhood Hits	378
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

LSAMP_HUMAN
NC score	0.400065 (rank : 885)	θ value	1.42992e-13 (rank : 494)
Query Neighborhood Hits	1931	Target Neighborhood Hits	347	Shared Neighborhood Hits	321
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

LSAMP_MOUSE
NC score	0.399467 (rank : 886)	θ value	7.09661e-13 (rank : 528)
Query Neighborhood Hits	1931	Target Neighborhood Hits	344	Shared Neighborhood Hits	320
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

CNTN6_HUMAN
NC score	0.398773 (rank : 887)	θ value	4.44505e-15 (rank : 434)
Query Neighborhood Hits	1931	Target Neighborhood Hits	422	Shared Neighborhood Hits	364
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CNTN3_MOUSE
NC score	0.398576 (rank : 888)	θ value	2.97466e-19 (rank : 277)
Query Neighborhood Hits	1931	Target Neighborhood Hits	447	Shared Neighborhood Hits	374
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN1_MOUSE
NC score	0.398221 (rank : 889)	θ value	1.80466e-16 (rank : 388)
Query Neighborhood Hits	1931	Target Neighborhood Hits	422	Shared Neighborhood Hits	359
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN1_HUMAN
NC score	0.398206 (rank : 890)	θ value	1.24977e-17 (rank : 340)
Query Neighborhood Hits	1931	Target Neighborhood Hits	431	Shared Neighborhood Hits	356
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

OPCM_HUMAN
NC score	0.395659 (rank : 891)	θ value	9.26847e-13 (rank : 539)
Query Neighborhood Hits	1931	Target Neighborhood Hits	332	Shared Neighborhood Hits	309
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

MYPC1_HUMAN
NC score	0.393747 (rank : 892)	θ value	1.08979e-29 (rank : 59)
Query Neighborhood Hits	1931	Target Neighborhood Hits	303	Shared Neighborhood Hits	271
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

CHL1_MOUSE
NC score	0.393507 (rank : 893)	θ value	6.41864e-14 (rank : 481)
Query Neighborhood Hits	1931	Target Neighborhood Hits	402	Shared Neighborhood Hits	345
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

NTRI_MOUSE
NC score	0.392805 (rank : 894)	θ value	1.02475e-11 (rank : 579)
Query Neighborhood Hits	1931	Target Neighborhood Hits	342	Shared Neighborhood Hits	316
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

ILK2_HUMAN
NC score	0.392411 (rank : 895)	θ value	0.125558 (rank : 1188)
Query Neighborhood Hits	1931	Target Neighborhood Hits	848	Shared Neighborhood Hits	585
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

CHL1_HUMAN
NC score	0.392393 (rank : 896)	θ value	8.38298e-14 (rank : 482)
Query Neighborhood Hits	1931	Target Neighborhood Hits	413	Shared Neighborhood Hits	355
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

NTRI_HUMAN
NC score	0.392150 (rank : 897)	θ value	6.00763e-12 (rank : 569)
Query Neighborhood Hits	1931	Target Neighborhood Hits	344	Shared Neighborhood Hits	317
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

NEGR1_HUMAN
NC score	0.390445 (rank : 898)	θ value	7.09661e-13 (rank : 532)
Query Neighborhood Hits	1931	Target Neighborhood Hits	346	Shared Neighborhood Hits	312
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

NEGR1_MOUSE
NC score	0.389016 (rank : 899)	θ value	2.0648e-12 (rank : 548)
Query Neighborhood Hits	1931	Target Neighborhood Hits	349	Shared Neighborhood Hits	311
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

ROBO4_MOUSE
NC score	0.386006 (rank : 900)	θ value	1.02475e-11 (rank : 582)
Query Neighborhood Hits	1931	Target Neighborhood Hits	358	Shared Neighborhood Hits	295
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

MYPC2_HUMAN
NC score	0.385679 (rank : 901)	θ value	2.68423e-28 (rank : 78)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	279
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

MAMC1_HUMAN
NC score	0.383955 (rank : 902)	θ value	1.86753e-13 (rank : 502)
Query Neighborhood Hits	1931	Target Neighborhood Hits	357	Shared Neighborhood Hits	311
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_MOUSE
NC score	0.382463 (rank : 903)	θ value	3.18553e-13 (rank : 514)
Query Neighborhood Hits	1931	Target Neighborhood Hits	357	Shared Neighborhood Hits	309
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MYPC3_MOUSE
NC score	0.381906 (rank : 904)	θ value	8.61488e-35 (rank : 37)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	276
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC3_HUMAN
NC score	0.381156 (rank : 905)	θ value	1.20211e-36 (rank : 32)
Query Neighborhood Hits	1931	Target Neighborhood Hits	318	Shared Neighborhood Hits	282
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC2_MOUSE
NC score	0.381072 (rank : 906)	θ value	6.61148e-27 (rank : 100)
Query Neighborhood Hits	1931	Target Neighborhood Hits	297	Shared Neighborhood Hits	264
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

ROBO4_HUMAN
NC score	0.380943 (rank : 907)	θ value	7.84624e-12 (rank : 575)
Query Neighborhood Hits	1931	Target Neighborhood Hits	364	Shared Neighborhood Hits	293
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

SN_MOUSE
NC score	0.378951 (rank : 908)	θ value	5.23862e-24 (rank : 155)
Query Neighborhood Hits	1931	Target Neighborhood Hits	416	Shared Neighborhood Hits	320
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

MDGA1_HUMAN
NC score	0.378182 (rank : 909)	θ value	1.2105e-12 (rank : 541)
Query Neighborhood Hits	1931	Target Neighborhood Hits	358	Shared Neighborhood Hits	309
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

BUB1_HUMAN
NC score	0.378167 (rank : 910)	θ value	θ > 10 (rank : 1944)
Query Neighborhood Hits	1931	Target Neighborhood Hits	543	Shared Neighborhood Hits	412
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

SN_HUMAN
NC score	0.376772 (rank : 911)	θ value	1.12775e-26 (rank : 108)
Query Neighborhood Hits	1931	Target Neighborhood Hits	434	Shared Neighborhood Hits	339
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

NPHN_HUMAN
NC score	0.375782 (rank : 912)	θ value	7.09661e-13 (rank : 533)
Query Neighborhood Hits	1931	Target Neighborhood Hits	362	Shared Neighborhood Hits	310
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

VCAM1_HUMAN
NC score	0.374335 (rank : 913)	θ value	8.11959e-09 (rank : 710)
Query Neighborhood Hits	1931	Target Neighborhood Hits	352	Shared Neighborhood Hits	284
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

VCAM1_MOUSE
NC score	0.373777 (rank : 914)	θ value	3.41135e-07 (rank : 798)
Query Neighborhood Hits	1931	Target Neighborhood Hits	320	Shared Neighborhood Hits	274
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

NPHN_MOUSE
NC score	0.372087 (rank : 915)	θ value	5.43371e-13 (rank : 525)
Query Neighborhood Hits	1931	Target Neighborhood Hits	370	Shared Neighborhood Hits	311
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

MYOM2_HUMAN
NC score	0.371836 (rank : 916)	θ value	4.16044e-13 (rank : 520)
Query Neighborhood Hits	1931	Target Neighborhood Hits	341	Shared Neighborhood Hits	286
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYOM1_MOUSE
NC score	0.368151 (rank : 917)	θ value	7.84624e-12 (rank : 574)
Query Neighborhood Hits	1931	Target Neighborhood Hits	415	Shared Neighborhood Hits	314
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MAG_MOUSE
NC score	0.365082 (rank : 918)	θ value	1.25267e-09 (rank : 664)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	256
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MAG_HUMAN
NC score	0.364478 (rank : 919)	θ value	2.52405e-10 (rank : 637)
Query Neighborhood Hits	1931	Target Neighborhood Hits	278	Shared Neighborhood Hits	261
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MYOM1_HUMAN
NC score	0.360237 (rank : 920)	θ value	4.59992e-12 (rank : 566)
Query Neighborhood Hits	1931	Target Neighborhood Hits	405	Shared Neighborhood Hits	299
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

CD22_HUMAN
NC score	0.358058 (rank : 921)	θ value	2.52405e-10 (rank : 632)
Query Neighborhood Hits	1931	Target Neighborhood Hits	365	Shared Neighborhood Hits	291
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CD22_MOUSE
NC score	0.356632 (rank : 922)	θ value	5.08577e-11 (rank : 609)
Query Neighborhood Hits	1931	Target Neighborhood Hits	331	Shared Neighborhood Hits	273
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

KIRR2_HUMAN
NC score	0.355784 (rank : 923)	θ value	9.59137e-10 (rank : 657)
Query Neighborhood Hits	1931	Target Neighborhood Hits	321	Shared Neighborhood Hits	271
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

KIRR2_MOUSE
NC score	0.352871 (rank : 924)	θ value	6.00763e-12 (rank : 568)
Query Neighborhood Hits	1931	Target Neighborhood Hits	326	Shared Neighborhood Hits	271
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

LU_HUMAN
NC score	0.351064 (rank : 925)	θ value	1.80886e-08 (rank : 722)
Query Neighborhood Hits	1931	Target Neighborhood Hits	283	Shared Neighborhood Hits	260
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

PI3R4_MOUSE
NC score	0.349840 (rank : 926)	θ value	1.06291 (rank : 1418)
Query Neighborhood Hits	1931	Target Neighborhood Hits	535	Shared Neighborhood Hits	356
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

MYBPH_HUMAN
NC score	0.347959 (rank : 927)	θ value	6.64225e-11 (rank : 614)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	237
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

RAGE_HUMAN
NC score	0.346837 (rank : 928)	θ value	9.92553e-07 (rank : 813)
Query Neighborhood Hits	1931	Target Neighborhood Hits	269	Shared Neighborhood Hits	252
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

TMIGD_HUMAN
NC score	0.346366 (rank : 929)	θ value	7.1131e-05 (rank : 925)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	225
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

MYBPH_MOUSE
NC score	0.345807 (rank : 930)	θ value	8.67504e-11 (rank : 617)
Query Neighborhood Hits	1931	Target Neighborhood Hits	290	Shared Neighborhood Hits	246
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

FSTL4_HUMAN
NC score	0.343970 (rank : 931)	θ value	5.26297e-08 (rank : 749)
Query Neighborhood Hits	1931	Target Neighborhood Hits	344	Shared Neighborhood Hits	270
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

STK31_HUMAN
NC score	0.343915 (rank : 932)	θ value	0.000461057 (rank : 967)
Query Neighborhood Hits	1931	Target Neighborhood Hits	570	Shared Neighborhood Hits	377
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

JAM1_HUMAN
NC score	0.343625 (rank : 933)	θ value	2.36244e-08 (rank : 730)
Query Neighborhood Hits	1931	Target Neighborhood Hits	294	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

MALT1_HUMAN
NC score	0.342850 (rank : 934)	θ value	0.00035302 (rank : 960)
Query Neighborhood Hits	1931	Target Neighborhood Hits	236	Shared Neighborhood Hits	223
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

FSTL5_HUMAN
NC score	0.339890 (rank : 935)	θ value	2.13673e-09 (rank : 672)
Query Neighborhood Hits	1931	Target Neighborhood Hits	347	Shared Neighborhood Hits	264
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

FSTL4_MOUSE
NC score	0.336539 (rank : 936)	θ value	3.41135e-07 (rank : 793)
Query Neighborhood Hits	1931	Target Neighborhood Hits	333	Shared Neighborhood Hits	261
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

FSTL5_MOUSE
NC score	0.336342 (rank : 937)	θ value	2.13673e-09 (rank : 673)
Query Neighborhood Hits	1931	Target Neighborhood Hits	355	Shared Neighborhood Hits	261
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

PI3R4_HUMAN
NC score	0.335909 (rank : 938)	θ value	1.06291 (rank : 1417)
Query Neighborhood Hits	1931	Target Neighborhood Hits	534	Shared Neighborhood Hits	348
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

NTKL_MOUSE
NC score	0.335109 (rank : 939)	θ value	θ > 10 (rank : 2010)
Query Neighborhood Hits	1931	Target Neighborhood Hits	326	Shared Neighborhood Hits	298
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

KIRR3_HUMAN
NC score	0.334532 (rank : 940)	θ value	2.61198e-07 (rank : 783)
Query Neighborhood Hits	1931	Target Neighborhood Hits	302	Shared Neighborhood Hits	265
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

TMIGD_MOUSE
NC score	0.333732 (rank : 941)	θ value	3.19293e-05 (rank : 904)
Query Neighborhood Hits	1931	Target Neighborhood Hits	234	Shared Neighborhood Hits	229
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

ICAM5_MOUSE
NC score	0.332969 (rank : 942)	θ value	8.11959e-09 (rank : 706)
Query Neighborhood Hits	1931	Target Neighborhood Hits	308	Shared Neighborhood Hits	256
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

NPTN_MOUSE
NC score	0.332231 (rank : 943)	θ value	9.92553e-07 (rank : 812)
Query Neighborhood Hits	1931	Target Neighborhood Hits	216	Shared Neighborhood Hits	208
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

KIRR3_MOUSE
NC score	0.332085 (rank : 944)	θ value	8.97725e-08 (rank : 761)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	256
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

KIRR1_HUMAN
NC score	0.331885 (rank : 945)	θ value	3.08544e-08 (rank : 738)
Query Neighborhood Hits	1931	Target Neighborhood Hits	401	Shared Neighborhood Hits	302
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

JAM1_MOUSE
NC score	0.330546 (rank : 946)	θ value	1.99992e-07 (rank : 779)
Query Neighborhood Hits	1931	Target Neighborhood Hits	287	Shared Neighborhood Hits	255
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

HMCN1_HUMAN
NC score	0.329367 (rank : 947)	θ value	6.80647e-157 (rank : 4)
Query Neighborhood Hits	1931	Target Neighborhood Hits	983	Shared Neighborhood Hits	436
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

KIRR1_MOUSE
NC score	0.328811 (rank : 948)	θ value	4.0297e-08 (rank : 744)
Query Neighborhood Hits	1931	Target Neighborhood Hits	403	Shared Neighborhood Hits	299
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

JAM2_HUMAN
NC score	0.328662 (rank : 949)	θ value	1.43324e-05 (rank : 879)
Query Neighborhood Hits	1931	Target Neighborhood Hits	304	Shared Neighborhood Hits	280
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

NPTN_HUMAN
NC score	0.328565 (rank : 950)	θ value	1.87187e-05 (rank : 891)
Query Neighborhood Hits	1931	Target Neighborhood Hits	212	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

RAGE_MOUSE
NC score	0.327440 (rank : 951)	θ value	9.29e-05 (rank : 932)
Query Neighborhood Hits	1931	Target Neighborhood Hits	295	Shared Neighborhood Hits	233
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

JAM3_MOUSE
NC score	0.327425 (rank : 952)	θ value	0.000270298 (rank : 953)
Query Neighborhood Hits	1931	Target Neighborhood Hits	286	Shared Neighborhood Hits	249
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

CEAM5_HUMAN
NC score	0.327333 (rank : 953)	θ value	6.41864e-14 (rank : 480)
Query Neighborhood Hits	1931	Target Neighborhood Hits	343	Shared Neighborhood Hits	289
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

JAM3_HUMAN
NC score	0.326225 (rank : 954)	θ value	0.000786445 (rank : 978)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	246
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

PGBM_HUMAN
NC score	0.323939 (rank : 955)	θ value	5.91091e-68 (rank : 7)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1113	Shared Neighborhood Hits	448
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

MUC18_HUMAN
NC score	0.321779 (rank : 956)	θ value	0.00175202 (rank : 998)
Query Neighborhood Hits	1931	Target Neighborhood Hits	275	Shared Neighborhood Hits	237
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

ICAM5_HUMAN
NC score	0.320278 (rank : 957)	θ value	8.97725e-08 (rank : 760)
Query Neighborhood Hits	1931	Target Neighborhood Hits	276	Shared Neighborhood Hits	245
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

CEAM1_MOUSE
NC score	0.319724 (rank : 958)	θ value	9.59137e-10 (rank : 655)
Query Neighborhood Hits	1931	Target Neighborhood Hits	326	Shared Neighborhood Hits	280
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

IGS4B_MOUSE
NC score	0.319077 (rank : 959)	θ value	3.08544e-08 (rank : 737)
Query Neighborhood Hits	1931	Target Neighborhood Hits	328	Shared Neighborhood Hits	280
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

K2002_HUMAN
NC score	0.318941 (rank : 960)	θ value	1.81305 (rank : 1497)
Query Neighborhood Hits	1931	Target Neighborhood Hits	274	Shared Neighborhood Hits	264
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

JAM2_MOUSE
NC score	0.318824 (rank : 961)	θ value	0.000602161 (rank : 972)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	264
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

CEA20_HUMAN
NC score	0.318028 (rank : 962)	θ value	5.62301e-10 (rank : 647)
Query Neighborhood Hits	1931	Target Neighborhood Hits	251	Shared Neighborhood Hits	219
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

MUC18_MOUSE
NC score	0.317500 (rank : 963)	θ value	0.00390308 (rank : 1023)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	243
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

FCRL5_HUMAN
NC score	0.314606 (rank : 964)	θ value	3.89403e-11 (rank : 605)
Query Neighborhood Hits	1931	Target Neighborhood Hits	267	Shared Neighborhood Hits	236
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

IGS4B_HUMAN
NC score	0.312089 (rank : 965)	θ value	1.38499e-08 (rank : 715)
Query Neighborhood Hits	1931	Target Neighborhood Hits	305	Shared Neighborhood Hits	262
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

PGBM_MOUSE
NC score	0.309819 (rank : 966)	θ value	3.74554e-30 (rank : 56)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1073	Shared Neighborhood Hits	430
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

RN5A_MOUSE
NC score	0.308771 (rank : 967)	θ value	0.279714 (rank : 1257)
Query Neighborhood Hits	1931	Target Neighborhood Hits	899	Shared Neighborhood Hits	614
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

LRIG1_HUMAN
NC score	0.307561 (rank : 968)	θ value	1.63225e-17 (rank : 346)
Query Neighborhood Hits	1931	Target Neighborhood Hits	654	Shared Neighborhood Hits	347
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

BASI_HUMAN
NC score	0.306454 (rank : 969)	θ value	4.76016e-09 (rank : 692)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	201
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

SIG11_HUMAN
NC score	0.305817 (rank : 970)	θ value	2.21117e-06 (rank : 838)
Query Neighborhood Hits	1931	Target Neighborhood Hits	273	Shared Neighborhood Hits	251
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

FCRL2_HUMAN
NC score	0.305677 (rank : 971)	θ value	2.52405e-10 (rank : 635)
Query Neighborhood Hits	1931	Target Neighborhood Hits	251	Shared Neighborhood Hits	224
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

KAZD1_MOUSE
NC score	0.305501 (rank : 972)	θ value	8.11959e-09 (rank : 707)
Query Neighborhood Hits	1931	Target Neighborhood Hits	281	Shared Neighborhood Hits	206
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

LRIG2_HUMAN
NC score	0.303030 (rank : 973)	θ value	7.32683e-18 (rank : 333)
Query Neighborhood Hits	1931	Target Neighborhood Hits	595	Shared Neighborhood Hits	325
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

VSIG2_HUMAN
NC score	0.302740 (rank : 974)	θ value	0.00390308 (rank : 1027)
Query Neighborhood Hits	1931	Target Neighborhood Hits	321	Shared Neighborhood Hits	253
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

SIG10_HUMAN
NC score	0.302342 (rank : 975)	θ value	1.87187e-05 (rank : 892)
Query Neighborhood Hits	1931	Target Neighborhood Hits	363	Shared Neighborhood Hits	277
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

LRIG2_MOUSE
NC score	0.301570 (rank : 976)	θ value	2.97466e-19 (rank : 278)
Query Neighborhood Hits	1931	Target Neighborhood Hits	586	Shared Neighborhood Hits	320
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

LRIG1_MOUSE
NC score	0.301126 (rank : 977)	θ value	4.29542e-18 (rank : 326)
Query Neighborhood Hits	1931	Target Neighborhood Hits	627	Shared Neighborhood Hits	332
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

PTPRF_HUMAN
NC score	0.300481 (rank : 978)	θ value	1.86321e-21 (rank : 209)
Query Neighborhood Hits	1931	Target Neighborhood Hits	489	Shared Neighborhood Hits	355
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

BASI_MOUSE
NC score	0.299632 (rank : 979)	θ value	1.99992e-07 (rank : 773)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	223
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

PTPRD_MOUSE
NC score	0.299342 (rank : 980)	θ value	1.2077e-20 (rank : 235)
Query Neighborhood Hits	1931	Target Neighborhood Hits	491	Shared Neighborhood Hits	349
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

CEAM1_HUMAN
NC score	0.297262 (rank : 981)	θ value	1.80886e-08 (rank : 719)
Query Neighborhood Hits	1931	Target Neighborhood Hits	348	Shared Neighborhood Hits	274
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

VSIG2_MOUSE
NC score	0.296817 (rank : 982)	θ value	0.000270298 (rank : 956)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	247
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

STK31_MOUSE
NC score	0.295769 (rank : 983)	θ value	0.00102713 (rank : 986)
Query Neighborhood Hits	1931	Target Neighborhood Hits	474	Shared Neighborhood Hits	313
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

PTPRD_HUMAN
NC score	0.291832 (rank : 984)	θ value	5.99374e-20 (rank : 261)
Query Neighborhood Hits	1931	Target Neighborhood Hits	485	Shared Neighborhood Hits	342
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

LRIG3_MOUSE
NC score	0.290766 (rank : 985)	θ value	5.25075e-16 (rank : 407)
Query Neighborhood Hits	1931	Target Neighborhood Hits	611	Shared Neighborhood Hits	332
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

PTPRS_HUMAN
NC score	0.290564 (rank : 986)	θ value	1.02238e-19 (rank : 269)
Query Neighborhood Hits	1931	Target Neighborhood Hits	472	Shared Neighborhood Hits	339
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

MFA3L_HUMAN
NC score	0.290456 (rank : 987)	θ value	2.44474e-05 (rank : 898)
Query Neighborhood Hits	1931	Target Neighborhood Hits	230	Shared Neighborhood Hits	214
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

LRIG3_HUMAN
NC score	0.287645 (rank : 988)	θ value	5.25075e-16 (rank : 406)
Query Neighborhood Hits	1931	Target Neighborhood Hits	601	Shared Neighborhood Hits	326
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

CI094_HUMAN
NC score	0.287296 (rank : 989)	θ value	6.43352e-06 (rank : 860)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	234
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

NRG2_HUMAN
NC score	0.280155 (rank : 990)	θ value	4.92598e-06 (rank : 856)
Query Neighborhood Hits	1931	Target Neighborhood Hits	419	Shared Neighborhood Hits	262
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

KAZD1_HUMAN
NC score	0.278757 (rank : 991)	θ value	3.41135e-07 (rank : 796)
Query Neighborhood Hits	1931	Target Neighborhood Hits	248	Shared Neighborhood Hits	173
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

NRG2_MOUSE
NC score	0.273780 (rank : 992)	θ value	8.40245e-06 (rank : 867)
Query Neighborhood Hits	1931	Target Neighborhood Hits	392	Shared Neighborhood Hits	249
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

GPA33_MOUSE
NC score	0.266285 (rank : 993)	θ value	1.43324e-05 (rank : 878)
Query Neighborhood Hits	1931	Target Neighborhood Hits	294	Shared Neighborhood Hits	223
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

VSIG4_HUMAN
NC score	0.263337 (rank : 994)	θ value	1.06291 (rank : 1430)
Query Neighborhood Hits	1931	Target Neighborhood Hits	236	Shared Neighborhood Hits	213
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

K2002_MOUSE
NC score	0.262733 (rank : 995)	θ value	4.03905 (rank : 1660)
Query Neighborhood Hits	1931	Target Neighborhood Hits	267	Shared Neighborhood Hits	234
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

IBP7_HUMAN
NC score	0.262228 (rank : 996)	θ value	0.00228821 (rank : 1001)
Query Neighborhood Hits	1931	Target Neighborhood Hits	220	Shared Neighborhood Hits	171
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

CEAM6_HUMAN
NC score	0.261647 (rank : 997)	θ value	0.00102713 (rank : 982)
Query Neighborhood Hits	1931	Target Neighborhood Hits	308	Shared Neighborhood Hits	266
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

CD166_MOUSE
NC score	0.260039 (rank : 998)	θ value	0.0148317 (rank : 1062)
Query Neighborhood Hits	1931	Target Neighborhood Hits	252	Shared Neighborhood Hits	218
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

NTKL_HUMAN
NC score	0.257335 (rank : 999)	θ value	θ > 10 (rank : 2009)
Query Neighborhood Hits	1931	Target Neighborhood Hits	266	Shared Neighborhood Hits	230
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

VRK3_HUMAN
NC score	0.255797 (rank : 1000)	θ value	0.365318 (rank : 1297)
Query Neighborhood Hits	1931	Target Neighborhood Hits	349	Shared Neighborhood Hits	317
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

GPA33_HUMAN
NC score	0.253437 (rank : 1001)	θ value	3.41135e-07 (rank : 794)
Query Neighborhood Hits	1931	Target Neighborhood Hits	273	Shared Neighborhood Hits	213
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

FNDC3_MOUSE
NC score	0.253210 (rank : 1002)	θ value	2.88788e-06 (rank : 842)
Query Neighborhood Hits	1931	Target Neighborhood Hits	207	Shared Neighborhood Hits	145
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

IBP7_MOUSE
NC score	0.252648 (rank : 1003)	θ value	0.000461057 (rank : 963)
Query Neighborhood Hits	1931	Target Neighborhood Hits	230	Shared Neighborhood Hits	168
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

FNDC3_HUMAN
NC score	0.250600 (rank : 1004)	θ value	1.43324e-05 (rank : 877)
Query Neighborhood Hits	1931	Target Neighborhood Hits	196	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

CD166_HUMAN
NC score	0.248267 (rank : 1005)	θ value	0.0431538 (rank : 1113)
Query Neighborhood Hits	1931	Target Neighborhood Hits	247	Shared Neighborhood Hits	217
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

MFA3L_MOUSE
NC score	0.248034 (rank : 1006)	θ value	0.00134147 (rank : 989)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	197
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

SIGL5_MOUSE
NC score	0.245302 (rank : 1007)	θ value	0.00102713 (rank : 985)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	243
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

ESAM_HUMAN
NC score	0.235532 (rank : 1008)	θ value	0.00509761 (rank : 1028)
Query Neighborhood Hits	1931	Target Neighborhood Hits	251	Shared Neighborhood Hits	206
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

CEAM8_HUMAN
NC score	0.235368 (rank : 1009)	θ value	0.00102713 (rank : 983)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	229
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

PSG8_HUMAN
NC score	0.233283 (rank : 1010)	θ value	6.87365e-08 (rank : 754)
Query Neighborhood Hits	1931	Target Neighborhood Hits	239	Shared Neighborhood Hits	218
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

PSG3_HUMAN
NC score	0.232687 (rank : 1011)	θ value	1.29631e-06 (rank : 817)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	222
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

PSG4_HUMAN
NC score	0.231268 (rank : 1012)	θ value	1.17247e-07 (rank : 765)
Query Neighborhood Hits	1931	Target Neighborhood Hits	243	Shared Neighborhood Hits	222
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

VRK3_MOUSE
NC score	0.230986 (rank : 1013)	θ value	3.0926 (rank : 1617)
Query Neighborhood Hits	1931	Target Neighborhood Hits	342	Shared Neighborhood Hits	324
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

ATL3_HUMAN
NC score	0.229619 (rank : 1014)	θ value	3.08544e-08 (rank : 734)
Query Neighborhood Hits	1931	Target Neighborhood Hits	414	Shared Neighborhood Hits	278
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

PSG7_HUMAN
NC score	0.225874 (rank : 1015)	θ value	1.29631e-06 (rank : 818)
Query Neighborhood Hits	1931	Target Neighborhood Hits	239	Shared Neighborhood Hits	218
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

PSG11_HUMAN
NC score	0.221738 (rank : 1016)	θ value	0.00228821 (rank : 1003)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	210
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

PSG1_HUMAN
NC score	0.220690 (rank : 1017)	θ value	2.88788e-06 (rank : 845)
Query Neighborhood Hits	1931	Target Neighborhood Hits	232	Shared Neighborhood Hits	213
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

PSG2_HUMAN
NC score	0.219160 (rank : 1018)	θ value	0.00298849 (rank : 1010)
Query Neighborhood Hits	1931	Target Neighborhood Hits	229	Shared Neighborhood Hits	213
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

PSG6_HUMAN
NC score	0.216036 (rank : 1019)	θ value	0.000158464 (rank : 942)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	212
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

NRG1_HUMAN
NC score	0.215112 (rank : 1020)	θ value	0.000270298 (rank : 954)
Query Neighborhood Hits	1931	Target Neighborhood Hits	285	Shared Neighborhood Hits	180
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

PSG10_HUMAN
NC score	0.213804 (rank : 1021)	θ value	0.000158464 (rank : 941)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	209
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG9_HUMAN
NC score	0.212353 (rank : 1022)	θ value	1.29631e-06 (rank : 819)
Query Neighborhood Hits	1931	Target Neighborhood Hits	221	Shared Neighborhood Hits	207
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

ESAM_MOUSE
NC score	0.209346 (rank : 1023)	θ value	0.0113563 (rank : 1054)
Query Neighborhood Hits	1931	Target Neighborhood Hits	222	Shared Neighborhood Hits	188
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

PSG5_HUMAN
NC score	0.209301 (rank : 1024)	θ value	0.00020696 (rank : 947)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	211
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

LRFN4_HUMAN
NC score	0.206661 (rank : 1025)	θ value	2.61198e-07 (rank : 785)
Query Neighborhood Hits	1931	Target Neighborhood Hits	462	Shared Neighborhood Hits	234
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

IL1R2_HUMAN
NC score	0.205218 (rank : 1026)	θ value	0.000461057 (rank : 964)
Query Neighborhood Hits	1931	Target Neighborhood Hits	153	Shared Neighborhood Hits	144
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

SIGL5_HUMAN
NC score	0.204132 (rank : 1027)	θ value	0.163984 (rank : 1223)
Query Neighborhood Hits	1931	Target Neighborhood Hits	246	Shared Neighborhood Hits	207
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

LRFN4_MOUSE
NC score	0.203591 (rank : 1028)	θ value	1.69304e-06 (rank : 828)
Query Neighborhood Hits	1931	Target Neighborhood Hits	442	Shared Neighborhood Hits	226
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

SIGL8_HUMAN
NC score	0.203329 (rank : 1029)	θ value	0.00665767 (rank : 1044)
Query Neighborhood Hits	1931	Target Neighborhood Hits	252	Shared Neighborhood Hits	224
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

CXAR_HUMAN
NC score	0.202927 (rank : 1030)	θ value	0.0148317 (rank : 1063)
Query Neighborhood Hits	1931	Target Neighborhood Hits	245	Shared Neighborhood Hits	188
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

CILP2_HUMAN
NC score	0.202603 (rank : 1031)	θ value	0.00175202 (rank : 993)
Query Neighborhood Hits	1931	Target Neighborhood Hits	307	Shared Neighborhood Hits	207
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

LRFN2_HUMAN
NC score	0.202429 (rank : 1032)	θ value	4.45536e-07 (rank : 800)
Query Neighborhood Hits	1931	Target Neighborhood Hits	450	Shared Neighborhood Hits	224
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN2_MOUSE
NC score	0.201757 (rank : 1033)	θ value	2.61198e-07 (rank : 784)
Query Neighborhood Hits	1931	Target Neighborhood Hits	450	Shared Neighborhood Hits	229
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

LRFN3_MOUSE
NC score	0.201105 (rank : 1034)	θ value	2.44474e-05 (rank : 896)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	231
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

PECA1_HUMAN
NC score	0.199071 (rank : 1035)	θ value	0.00509761 (rank : 1033)
Query Neighborhood Hits	1931	Target Neighborhood Hits	178	Shared Neighborhood Hits	155
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

SIG12_HUMAN
NC score	0.197593 (rank : 1036)	θ value	0.00390308 (rank : 1025)
Query Neighborhood Hits	1931	Target Neighborhood Hits	245	Shared Neighborhood Hits	227
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

LRFN3_HUMAN
NC score	0.193134 (rank : 1037)	θ value	1.69304e-06 (rank : 827)
Query Neighborhood Hits	1931	Target Neighborhood Hits	444	Shared Neighborhood Hits	217
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

CXAR_MOUSE
NC score	0.192096 (rank : 1038)	θ value	0.163984 (rank : 1207)
Query Neighborhood Hits	1931	Target Neighborhood Hits	250	Shared Neighborhood Hits	187
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

LRC21_MOUSE
NC score	0.191561 (rank : 1039)	θ value	1.87187e-05 (rank : 888)
Query Neighborhood Hits	1931	Target Neighborhood Hits	462	Shared Neighborhood Hits	240
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRFN5_MOUSE
NC score	0.191220 (rank : 1040)	θ value	1.69304e-06 (rank : 829)
Query Neighborhood Hits	1931	Target Neighborhood Hits	472	Shared Neighborhood Hits	236
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

LRC21_HUMAN
NC score	0.191194 (rank : 1041)	θ value	4.92598e-06 (rank : 855)
Query Neighborhood Hits	1931	Target Neighborhood Hits	456	Shared Neighborhood Hits	239
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

CD276_HUMAN
NC score	0.189515 (rank : 1042)	θ value	0.163984 (rank : 1204)
Query Neighborhood Hits	1931	Target Neighborhood Hits	261	Shared Neighborhood Hits	188
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

LRFN5_HUMAN
NC score	0.187124 (rank : 1043)	θ value	3.77169e-06 (rank : 846)
Query Neighborhood Hits	1931	Target Neighborhood Hits	464	Shared Neighborhood Hits	231
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

IRPL2_HUMAN
NC score	0.186501 (rank : 1044)	θ value	3.19293e-05 (rank : 901)
Query Neighborhood Hits	1931	Target Neighborhood Hits	194	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

SIGL6_HUMAN
NC score	0.186087 (rank : 1045)	θ value	1.38821 (rank : 1466)
Query Neighborhood Hits	1931	Target Neighborhood Hits	233	Shared Neighborhood Hits	210
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

IRPL2_MOUSE
NC score	0.183497 (rank : 1046)	θ value	0.000121331 (rank : 936)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	156
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

IRPL1_MOUSE
NC score	0.181179 (rank : 1047)	θ value	0.00020696 (rank : 945)
Query Neighborhood Hits	1931	Target Neighborhood Hits	186	Shared Neighborhood Hits	168
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

IRPL1_HUMAN
NC score	0.177090 (rank : 1048)	θ value	0.00035302 (rank : 958)
Query Neighborhood Hits	1931	Target Neighborhood Hits	196	Shared Neighborhood Hits	176
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

CILP1_MOUSE
NC score	0.174485 (rank : 1049)	θ value	0.00298849 (rank : 1008)
Query Neighborhood Hits	1931	Target Neighborhood Hits	282	Shared Neighborhood Hits	199
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

IL1R2_MOUSE
NC score	0.173797 (rank : 1050)	θ value	0.0330416 (rank : 1096)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	111
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

PVRL3_MOUSE
NC score	0.172858 (rank : 1051)	θ value	0.62314 (rank : 1346)
Query Neighborhood Hits	1931	Target Neighborhood Hits	212	Shared Neighborhood Hits	173
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

LRRN3_HUMAN
NC score	0.171309 (rank : 1052)	θ value	2.44474e-05 (rank : 897)
Query Neighborhood Hits	1931	Target Neighborhood Hits	461	Shared Neighborhood Hits	231
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PIGR_MOUSE
NC score	0.170097 (rank : 1053)	θ value	0.00035302 (rank : 961)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	164
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

PGFRL_HUMAN
NC score	0.168933 (rank : 1054)	θ value	0.00665767 (rank : 1042)
Query Neighborhood Hits	1931	Target Neighborhood Hits	115	Shared Neighborhood Hits	112
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

FINC_MOUSE
NC score	0.168457 (rank : 1055)	θ value	0.00390308 (rank : 1017)
Query Neighborhood Hits	1931	Target Neighborhood Hits	309	Shared Neighborhood Hits	158
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

PVRL3_HUMAN
NC score	0.166292 (rank : 1056)	θ value	1.81305 (rank : 1510)
Query Neighborhood Hits	1931	Target Neighborhood Hits	204	Shared Neighborhood Hits	166
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

PKHG4_HUMAN
NC score	0.165796 (rank : 1057)	θ value	4.9032e-22 (rank : 198)
Query Neighborhood Hits	1931	Target Neighborhood Hits	200	Shared Neighborhood Hits	109
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

FINC_HUMAN
NC score	0.165152 (rank : 1058)	θ value	0.00509761 (rank : 1031)
Query Neighborhood Hits	1931	Target Neighborhood Hits	302	Shared Neighborhood Hits	157
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

PXK_MOUSE
NC score	0.165091 (rank : 1059)	θ value	θ > 10 (rank : 2026)
Query Neighborhood Hits	1931	Target Neighborhood Hits	320	Shared Neighborhood Hits	216
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

LRRN1_HUMAN
NC score	0.163011 (rank : 1060)	θ value	0.0961366 (rank : 1175)
Query Neighborhood Hits	1931	Target Neighborhood Hits	518	Shared Neighborhood Hits	261
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

CILP1_HUMAN
NC score	0.162904 (rank : 1061)	θ value	0.0193708 (rank : 1070)
Query Neighborhood Hits	1931	Target Neighborhood Hits	266	Shared Neighborhood Hits	178
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

LRRN5_HUMAN
NC score	0.162303 (rank : 1062)	θ value	2.21117e-06 (rank : 835)
Query Neighborhood Hits	1931	Target Neighborhood Hits	493	Shared Neighborhood Hits	246
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

PECA1_MOUSE
NC score	0.161515 (rank : 1063)	θ value	0.00134147 (rank : 990)
Query Neighborhood Hits	1931	Target Neighborhood Hits	126	Shared Neighborhood Hits	111
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

LRRN3_MOUSE
NC score	0.161434 (rank : 1064)	θ value	0.000461057 (rank : 965)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	228
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

IL1R1_HUMAN
NC score	0.161116 (rank : 1065)	θ value	0.00035302 (rank : 957)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	128
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

MCF2_HUMAN
NC score	0.160997 (rank : 1066)	θ value	2.51237e-26 (rank : 115)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	61
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

PVRL1_HUMAN
NC score	0.160958 (rank : 1067)	θ value	4.03905 (rank : 1677)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	171
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

EMB_MOUSE
NC score	0.159194 (rank : 1068)	θ value	0.00390308 (rank : 1016)
Query Neighborhood Hits	1931	Target Neighborhood Hits	83	Shared Neighborhood Hits	81
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

PIGR_HUMAN
NC score	0.158393 (rank : 1069)	θ value	1.69304e-06 (rank : 830)
Query Neighborhood Hits	1931	Target Neighborhood Hits	164	Shared Neighborhood Hits	125
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

MCF2L_MOUSE
NC score	0.157982 (rank : 1070)	θ value	1.12775e-26 (rank : 105)
Query Neighborhood Hits	1931	Target Neighborhood Hits	255	Shared Neighborhood Hits	82
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

UNC5D_MOUSE
NC score	0.157541 (rank : 1071)	θ value	0.365318 (rank : 1295)
Query Neighborhood Hits	1931	Target Neighborhood Hits	268	Shared Neighborhood Hits	187
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

LRRN1_MOUSE
NC score	0.157109 (rank : 1072)	θ value	0.163984 (rank : 1216)
Query Neighborhood Hits	1931	Target Neighborhood Hits	508	Shared Neighborhood Hits	256
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

UNC5D_HUMAN
NC score	0.155929 (rank : 1073)	θ value	0.365318 (rank : 1294)
Query Neighborhood Hits	1931	Target Neighborhood Hits	267	Shared Neighborhood Hits	186
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

CEAM7_HUMAN
NC score	0.155393 (rank : 1074)	θ value	0.21417 (rank : 1226)
Query Neighborhood Hits	1931	Target Neighborhood Hits	170	Shared Neighborhood Hits	151
SwissProt Accessions	Q14002, O15148, O15149, Q13983, Q9UPJ2	Gene names	CEACAM7, CGM2
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 7 precursor (Carcinoembryonic antigen CGM2).

ILRL2_MOUSE
NC score	0.154390 (rank : 1075)	θ value	0.00102713 (rank : 984)
Query Neighborhood Hits	1931	Target Neighborhood Hits	158	Shared Neighborhood Hits	148
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

PVRL1_MOUSE
NC score	0.152922 (rank : 1076)	θ value	1.81305 (rank : 1509)
Query Neighborhood Hits	1931	Target Neighborhood Hits	201	Shared Neighborhood Hits	164
SwissProt Accessions	Q9JKF6, Q9ERL5, Q9JI17	Gene names	Pvrl1, Hvec, Prr1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (CD111 antigen).

CD276_MOUSE
NC score	0.152652 (rank : 1077)	θ value	θ > 10 (rank : 1947)
Query Neighborhood Hits	1931	Target Neighborhood Hits	243	Shared Neighborhood Hits	184
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

SIGL7_HUMAN
NC score	0.152372 (rank : 1078)	θ value	0.0961366 (rank : 1179)
Query Neighborhood Hits	1931	Target Neighborhood Hits	180	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

PGFRL_MOUSE
NC score	0.150431 (rank : 1079)	θ value	0.00509761 (rank : 1034)
Query Neighborhood Hits	1931	Target Neighborhood Hits	106	Shared Neighborhood Hits	97
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

HAPIP_HUMAN
NC score	0.149477 (rank : 1080)	θ value	1.47289e-26 (rank : 109)
Query Neighborhood Hits	1931	Target Neighborhood Hits	350	Shared Neighborhood Hits	86
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

MOX2R_MOUSE
NC score	0.147161 (rank : 1081)	θ value	0.365318 (rank : 1286)
Query Neighborhood Hits	1931	Target Neighborhood Hits	110	Shared Neighborhood Hits	101
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

LRC24_HUMAN
NC score	0.146444 (rank : 1082)	θ value	4.1701e-05 (rank : 908)
Query Neighborhood Hits	1931	Target Neighborhood Hits	404	Shared Neighborhood Hits	198
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

ILRL1_HUMAN
NC score	0.144743 (rank : 1083)	θ value	0.0252991 (rank : 1082)
Query Neighborhood Hits	1931	Target Neighborhood Hits	167	Shared Neighborhood Hits	137
SwissProt Accessions	Q01638, Q53TU7, Q8NEJ3, Q9ULV7, Q9UQ44	Gene names	IL1RL1, DER4, ST2, T1
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein).

IL1R1_MOUSE
NC score	0.144633 (rank : 1084)	θ value	0.0330416 (rank : 1095)
Query Neighborhood Hits	1931	Target Neighborhood Hits	142	Shared Neighborhood Hits	130
SwissProt Accessions	P13504	Gene names	Il1r1, Il-1r1, Il1ra
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (p80) (CD121a antigen).

SIG12_MOUSE
NC score	0.144003 (rank : 1085)	θ value	0.00298849 (rank : 1012)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	182
SwissProt Accessions	Q91Y57	Gene names	Siglec12, Siglec5, Siglece, Siglecl1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1) (Sialic acid-binding Ig-like lectin 5) (Siglec-5) (mSiglec-E) (Myeloid inhibitory siglec) (MIS).

PKHG1_HUMAN
NC score	0.143354 (rank : 1086)	θ value	4.02038e-16 (rank : 403)
Query Neighborhood Hits	1931	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PRPK_HUMAN
NC score	0.143354 (rank : 1087)	θ value	θ > 10 (rank : 2020)
Query Neighborhood Hits	1931	Target Neighborhood Hits	131	Shared Neighborhood Hits	129
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
NC score	0.141427 (rank : 1088)	θ value	θ > 10 (rank : 2021)
Query Neighborhood Hits	1931	Target Neighborhood Hits	139	Shared Neighborhood Hits	133
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

VAV_HUMAN
NC score	0.141022 (rank : 1089)	θ value	1.38499e-08 (rank : 718)
Query Neighborhood Hits	1931	Target Neighborhood Hits	452	Shared Neighborhood Hits	150
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

IL6RB_HUMAN
NC score	0.140353 (rank : 1090)	θ value	θ > 10 (rank : 1994)
Query Neighborhood Hits	1931	Target Neighborhood Hits	181	Shared Neighborhood Hits	117
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

FCGR1_HUMAN
NC score	0.138677 (rank : 1091)	θ value	0.00298849 (rank : 1009)
Query Neighborhood Hits	1931	Target Neighborhood Hits	145	Shared Neighborhood Hits	118
SwissProt Accessions	P12314, P12315, Q92495, Q92663	Gene names	FCGR1A, FCG1, FCGR1, IGFR1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I) (CD64 antigen).

RN5A_HUMAN
NC score	0.137776 (rank : 1092)	θ value	θ > 10 (rank : 2033)
Query Neighborhood Hits	1931	Target Neighborhood Hits	608	Shared Neighborhood Hits	336
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

PDL1_HUMAN
NC score	0.137645 (rank : 1093)	θ value	6.88961 (rank : 1798)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	152
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PVRL2_MOUSE
NC score	0.136794 (rank : 1094)	θ value	3.0926 (rank : 1614)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	144
SwissProt Accessions	P32507, Q62096	Gene names	Pvrl2, Mph, Pvr, Pvs
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Murine herpesvirus entry protein B) (mHveB) (Nectin-2) (Poliovirus receptor homolog) (CD112 antigen).

PVR_HUMAN
NC score	0.136761 (rank : 1095)	θ value	θ > 10 (rank : 2024)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	152
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

NGL1_MOUSE
NC score	0.136436 (rank : 1096)	θ value	7.1131e-05 (rank : 921)
Query Neighborhood Hits	1931	Target Neighborhood Hits	512	Shared Neighborhood Hits	241
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_HUMAN
NC score	0.136279 (rank : 1097)	θ value	7.1131e-05 (rank : 920)
Query Neighborhood Hits	1931	Target Neighborhood Hits	511	Shared Neighborhood Hits	240
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

VAV3_HUMAN
NC score	0.135989 (rank : 1098)	θ value	0.0252991 (rank : 1089)
Query Neighborhood Hits	1931	Target Neighborhood Hits	398	Shared Neighborhood Hits	145
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV_MOUSE
NC score	0.135902 (rank : 1099)	θ value	8.40245e-06 (rank : 871)
Query Neighborhood Hits	1931	Target Neighborhood Hits	430	Shared Neighborhood Hits	147
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

LRC4B_MOUSE
NC score	0.135656 (rank : 1100)	θ value	0.000158464 (rank : 940)
Query Neighborhood Hits	1931	Target Neighborhood Hits	484	Shared Neighborhood Hits	233
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

VAV3_MOUSE
NC score	0.135441 (rank : 1101)	θ value	0.00869519 (rank : 1051)
Query Neighborhood Hits	1931	Target Neighborhood Hits	404	Shared Neighborhood Hits	148
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

LRC4B_HUMAN
NC score	0.134611 (rank : 1102)	θ value	0.000158464 (rank : 939)
Query Neighborhood Hits	1931	Target Neighborhood Hits	479	Shared Neighborhood Hits	233
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC24_MOUSE
NC score	0.134025 (rank : 1103)	θ value	1.87187e-05 (rank : 889)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	195
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

IGS21_MOUSE
NC score	0.133879 (rank : 1104)	θ value	0.21417 (rank : 1230)
Query Neighborhood Hits	1931	Target Neighborhood Hits	118	Shared Neighborhood Hits	108
SwissProt Accessions	Q7TNR6	Gene names	Igsf21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

IGS21_HUMAN
NC score	0.133356 (rank : 1105)	θ value	0.279714 (rank : 1250)
Query Neighborhood Hits	1931	Target Neighborhood Hits	123	Shared Neighborhood Hits	109
SwissProt Accessions	Q96ID5, Q8NBR8	Gene names	IGSF21
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 21 precursor.

FCERA_HUMAN
NC score	0.132516 (rank : 1106)	θ value	6.88961 (rank : 1773)
Query Neighborhood Hits	1931	Target Neighborhood Hits	150	Shared Neighborhood Hits	132
SwissProt Accessions	P12319	Gene names	FCER1A, FCE1A
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

USH2A_HUMAN
NC score	0.132041 (rank : 1107)	θ value	0.365318 (rank : 1296)
Query Neighborhood Hits	1931	Target Neighborhood Hits	600	Shared Neighborhood Hits	174
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

VAV2_HUMAN
NC score	0.130430 (rank : 1108)	θ value	1.81305 (rank : 1517)
Query Neighborhood Hits	1931	Target Neighborhood Hits	453	Shared Neighborhood Hits	148
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.130386 (rank : 1109)	θ value	0.21417 (rank : 1242)
Query Neighborhood Hits	1931	Target Neighborhood Hits	456	Shared Neighborhood Hits	148
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

PVRL2_HUMAN
NC score	0.126540 (rank : 1110)	θ value	0.813845 (rank : 1389)
Query Neighborhood Hits	1931	Target Neighborhood Hits	185	Shared Neighborhood Hits	136
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

USH2A_MOUSE
NC score	0.126285 (rank : 1111)	θ value	0.0961366 (rank : 1183)
Query Neighborhood Hits	1931	Target Neighborhood Hits	626	Shared Neighborhood Hits	187
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

ITB4_HUMAN
NC score	0.125147 (rank : 1112)	θ value	θ > 10 (rank : 1997)
Query Neighborhood Hits	1931	Target Neighborhood Hits	458	Shared Neighborhood Hits	159
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

LAG3_MOUSE
NC score	0.123954 (rank : 1113)	θ value	0.163984 (rank : 1214)
Query Neighborhood Hits	1931	Target Neighborhood Hits	117	Shared Neighborhood Hits	100
SwissProt Accessions	Q61790, Q0VBL2	Gene names	Lag3
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (CD223 antigen).

ARHG4_HUMAN
NC score	0.123774 (rank : 1114)	θ value	1.63604e-09 (rank : 666)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PXK_HUMAN
NC score	0.123659 (rank : 1115)	θ value	θ > 10 (rank : 2025)
Query Neighborhood Hits	1931	Target Neighborhood Hits	216	Shared Neighborhood Hits	145
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

UNC5C_MOUSE
NC score	0.123312 (rank : 1116)	θ value	0.0431538 (rank : 1126)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	141
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

ARHG9_MOUSE
NC score	0.123267 (rank : 1117)	θ value	6.00763e-12 (rank : 567)
Query Neighborhood Hits	1931	Target Neighborhood Hits	234	Shared Neighborhood Hits	90
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PDL2_MOUSE
NC score	0.122909 (rank : 1118)	θ value	0.279714 (rank : 1256)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	100
SwissProt Accessions	Q9WUL5	Gene names	Pdcd1lg2, B7dc, Btdc, Cd273, Pdl2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

ARHG9_HUMAN
NC score	0.122536 (rank : 1119)	θ value	8.67504e-11 (rank : 615)
Query Neighborhood Hits	1931	Target Neighborhood Hits	235	Shared Neighborhood Hits	91
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

COCA1_MOUSE
NC score	0.122472 (rank : 1120)	θ value	2.36792 (rank : 1535)
Query Neighborhood Hits	1931	Target Neighborhood Hits	467	Shared Neighborhood Hits	225
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

IL6RB_MOUSE
NC score	0.122064 (rank : 1121)	θ value	θ > 10 (rank : 1995)
Query Neighborhood Hits	1931	Target Neighborhood Hits	168	Shared Neighborhood Hits	115
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

UNC5C_HUMAN
NC score	0.121807 (rank : 1122)	θ value	0.125558 (rank : 1198)
Query Neighborhood Hits	1931	Target Neighborhood Hits	226	Shared Neighborhood Hits	136
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5A_HUMAN
NC score	0.120550 (rank : 1123)	θ value	6.88961 (rank : 1810)
Query Neighborhood Hits	1931	Target Neighborhood Hits	198	Shared Neighborhood Hits	127
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

LRRC4_HUMAN
NC score	0.118716 (rank : 1124)	θ value	0.125558 (rank : 1190)
Query Neighborhood Hits	1931	Target Neighborhood Hits	444	Shared Neighborhood Hits	203
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

ARHG4_MOUSE
NC score	0.118582 (rank : 1125)	θ value	6.87365e-08 (rank : 753)
Query Neighborhood Hits	1931	Target Neighborhood Hits	185	Shared Neighborhood Hits	72
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

FCGR1_MOUSE
NC score	0.118467 (rank : 1126)	θ value	0.0431538 (rank : 1117)
Query Neighborhood Hits	1931	Target Neighborhood Hits	123	Shared Neighborhood Hits	99
SwissProt Accessions	P26151	Gene names	Fcgr1, Fcg1
Domain Architecture
Description	High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma RI) (FcRI) (IgG Fc receptor I).

UNC5B_HUMAN
NC score	0.117305 (rank : 1127)	θ value	0.0330416 (rank : 1108)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	138
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

PREX1_HUMAN
NC score	0.117039 (rank : 1128)	θ value	9.59137e-10 (rank : 658)
Query Neighborhood Hits	1931	Target Neighborhood Hits	177	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ILRL1_MOUSE
NC score	0.116550 (rank : 1129)	θ value	0.0961366 (rank : 1173)
Query Neighborhood Hits	1931	Target Neighborhood Hits	172	Shared Neighborhood Hits	139
SwissProt Accessions	P14719, Q05208	Gene names	Il1rl1, Ly84, St2, Ste2
Domain Architecture
Description	Interleukin-1 receptor-like 1 precursor (ST2 protein) (T1 protein) (Lymphocyte antigen 84).

UNC5B_MOUSE
NC score	0.115531 (rank : 1130)	θ value	0.00665767 (rank : 1047)
Query Neighborhood Hits	1931	Target Neighborhood Hits	226	Shared Neighborhood Hits	137
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

COCA1_HUMAN
NC score	0.115380 (rank : 1131)	θ value	0.47712 (rank : 1300)
Query Neighborhood Hits	1931	Target Neighborhood Hits	458	Shared Neighborhood Hits	209
SwissProt Accessions	Q99715, Q99716	Gene names	COL12A1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

PDL1_MOUSE
NC score	0.113945 (rank : 1132)	θ value	4.03905 (rank : 1672)
Query Neighborhood Hits	1931	Target Neighborhood Hits	168	Shared Neighborhood Hits	133
SwissProt Accessions	Q9EP73	Gene names	Cd274, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

FGD3_MOUSE
NC score	0.113242 (rank : 1133)	θ value	7.84624e-12 (rank : 572)
Query Neighborhood Hits	1931	Target Neighborhood Hits	257	Shared Neighborhood Hits	82
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

JAML1_MOUSE
NC score	0.112602 (rank : 1134)	θ value	θ > 10 (rank : 1998)
Query Neighborhood Hits	1931	Target Neighborhood Hits	185	Shared Neighborhood Hits	136
SwissProt Accessions	Q80UL9, Q5DTC4	Gene names	Amica1, Gm638, Jaml
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (mCrea7).

TARSH_HUMAN
NC score	0.112351 (rank : 1135)	θ value	θ > 10 (rank : 2051)
Query Neighborhood Hits	1931	Target Neighborhood Hits	768	Shared Neighborhood Hits	302
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ARHG7_MOUSE
NC score	0.111994 (rank : 1136)	θ value	5.26297e-08 (rank : 745)
Query Neighborhood Hits	1931	Target Neighborhood Hits	396	Shared Neighborhood Hits	106
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

KALM_HUMAN
NC score	0.111511 (rank : 1137)	θ value	θ > 10 (rank : 1999)
Query Neighborhood Hits	1931	Target Neighborhood Hits	114	Shared Neighborhood Hits	72
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

ARHG7_HUMAN
NC score	0.111217 (rank : 1138)	θ value	1.69304e-06 (rank : 821)
Query Neighborhood Hits	1931	Target Neighborhood Hits	347	Shared Neighborhood Hits	103
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

LIFR_HUMAN
NC score	0.110606 (rank : 1139)	θ value	θ > 10 (rank : 2000)
Query Neighborhood Hits	1931	Target Neighborhood Hits	130	Shared Neighborhood Hits	84
SwissProt Accessions	P42702, Q6LCD9	Gene names	LIFR
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (CD118 antigen).

FGD3_HUMAN
NC score	0.109240 (rank : 1140)	θ value	1.9326e-10 (rank : 628)
Query Neighborhood Hits	1931	Target Neighborhood Hits	249	Shared Neighborhood Hits	88
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

PTPRM_HUMAN
NC score	0.108488 (rank : 1141)	θ value	1.81305 (rank : 1508)
Query Neighborhood Hits	1931	Target Neighborhood Hits	244	Shared Neighborhood Hits	147
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

HCFC2_MOUSE
NC score	0.108044 (rank : 1142)	θ value	θ > 10 (rank : 1983)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	85
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

I12R2_HUMAN
NC score	0.107915 (rank : 1143)	θ value	θ > 10 (rank : 1986)
Query Neighborhood Hits	1931	Target Neighborhood Hits	163	Shared Neighborhood Hits	105
SwissProt Accessions	Q99665	Gene names	IL12RB2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

ILRL2_HUMAN
NC score	0.107464 (rank : 1144)	θ value	0.000270298 (rank : 951)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	103
SwissProt Accessions	Q9HB29, Q13525, Q45H74	Gene names	IL1RL2, IL1RRP2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2) (Interleukin-1 receptor-related protein 2) (IL1R-rp2).

ARHG6_HUMAN
NC score	0.107403 (rank : 1145)	θ value	9.29e-05 (rank : 928)
Query Neighborhood Hits	1931	Target Neighborhood Hits	376	Shared Neighborhood Hits	107
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

CD80_MOUSE
NC score	0.107259 (rank : 1146)	θ value	1.81305 (rank : 1486)
Query Neighborhood Hits	1931	Target Neighborhood Hits	136	Shared Neighborhood Hits	114
SwissProt Accessions	Q00609, Q61332	Gene names	Cd80, B7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (B7).

UNC5A_MOUSE
NC score	0.106949 (rank : 1147)	θ value	6.88961 (rank : 1811)
Query Neighborhood Hits	1931	Target Neighborhood Hits	203	Shared Neighborhood Hits	124
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

I12R2_MOUSE
NC score	0.106543 (rank : 1148)	θ value	θ > 10 (rank : 1987)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	99
SwissProt Accessions	P97378	Gene names	Il12rb2
Domain Architecture
Description	Interleukin-12 receptor beta-2 chain precursor (IL-12 receptor beta-2) (IL-12R-beta2).

FCG2B_HUMAN
NC score	0.106439 (rank : 1149)	θ value	0.00509761 (rank : 1029)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	95
SwissProt Accessions	P31994, O95649, Q53X85, Q5VXA9, Q8NIA1	Gene names	FCGR2B, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-b precursor (Fc-gamma RII-b) (FcRII-b) (IgG Fc receptor II-b) (Fc-gamma-RIIb) (CD32 antigen) (CDw32).

FCG2C_HUMAN
NC score	0.106187 (rank : 1150)	θ value	0.00509761 (rank : 1030)
Query Neighborhood Hits	1931	Target Neighborhood Hits	118	Shared Neighborhood Hits	96
SwissProt Accessions	P31995, O00523, O00524, O00525	Gene names	FCGR2C, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-c precursor (Fc-gamma RII-c) (FcRII-c) (IgG Fc receptor II-c) (Fc-gamma-RIIc) (CD32 antigen) (CDw32).

FCRLA_MOUSE
NC score	0.106115 (rank : 1151)	θ value	1.43324e-05 (rank : 875)
Query Neighborhood Hits	1931	Target Neighborhood Hits	110	Shared Neighborhood Hits	79
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

PTPRM_MOUSE
NC score	0.105279 (rank : 1152)	θ value	3.0926 (rank : 1612)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	145
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

IGSF2_HUMAN
NC score	0.104872 (rank : 1153)	θ value	0.000786445 (rank : 977)
Query Neighborhood Hits	1931	Target Neighborhood Hits	208	Shared Neighborhood Hits	127
SwissProt Accessions	Q93033, Q15856	Gene names	IGSF2, CD101, EWI101, V7
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 2 precursor (Glu-Trp-Ile EWI motif- containing protein 101) (EWI-101) (Cell surface glycoprotein V7) (CD101 antigen).

HHLA2_HUMAN
NC score	0.104438 (rank : 1154)	θ value	6.88961 (rank : 1779)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	97
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

FGD2_HUMAN
NC score	0.104199 (rank : 1155)	θ value	8.11959e-09 (rank : 705)
Query Neighborhood Hits	1931	Target Neighborhood Hits	151	Shared Neighborhood Hits	60
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
NC score	0.103507 (rank : 1156)	θ value	7.34386e-10 (rank : 654)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	68
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FCRLA_HUMAN
NC score	0.103224 (rank : 1157)	θ value	1.87187e-05 (rank : 887)
Query Neighborhood Hits	1931	Target Neighborhood Hits	135	Shared Neighborhood Hits	82
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

TIAM1_MOUSE
NC score	0.102782 (rank : 1158)	θ value	3.77169e-06 (rank : 847)
Query Neighborhood Hits	1931	Target Neighborhood Hits	205	Shared Neighborhood Hits	71
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FGD4_MOUSE
NC score	0.102739 (rank : 1159)	θ value	2.79066e-09 (rank : 683)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

LIFR_MOUSE
NC score	0.102529 (rank : 1160)	θ value	θ > 10 (rank : 2001)
Query Neighborhood Hits	1931	Target Neighborhood Hits	127	Shared Neighborhood Hits	82
SwissProt Accessions	P42703	Gene names	Lifr
Domain Architecture
Description	Leukemia inhibitory factor receptor precursor (LIF receptor) (LIF-R) (D-factor/LIF receptor) (CD118 antigen).

LRRC4_MOUSE
NC score	0.102468 (rank : 1161)	θ value	0.21417 (rank : 1235)
Query Neighborhood Hits	1931	Target Neighborhood Hits	412	Shared Neighborhood Hits	174
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

FGD2_MOUSE
NC score	0.102463 (rank : 1162)	θ value	2.36244e-08 (rank : 727)
Query Neighborhood Hits	1931	Target Neighborhood Hits	163	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

LAG3_HUMAN
NC score	0.102397 (rank : 1163)	θ value	8.99809 (rank : 1874)
Query Neighborhood Hits	1931	Target Neighborhood Hits	129	Shared Neighborhood Hits	89
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

EMB_HUMAN
NC score	0.102387 (rank : 1164)	θ value	0.163984 (rank : 1209)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PCB8	Gene names	EMB
Domain Architecture	No domain graphic available
Description	Embigin precursor.

FGD1_MOUSE
NC score	0.100931 (rank : 1165)	θ value	0.000602161 (rank : 971)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	160
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

TIAM1_HUMAN
NC score	0.099818 (rank : 1166)	θ value	4.1701e-05 (rank : 912)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	74
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG6_MOUSE
NC score	0.099299 (rank : 1167)	θ value	0.000786445 (rank : 976)
Query Neighborhood Hits	1931	Target Neighborhood Hits	394	Shared Neighborhood Hits	103
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SLAP2_MOUSE
NC score	0.098681 (rank : 1168)	θ value	θ > 10 (rank : 2042)
Query Neighborhood Hits	1931	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

OX2G_MOUSE
NC score	0.098334 (rank : 1169)	θ value	θ > 10 (rank : 2012)
Query Neighborhood Hits	1931	Target Neighborhood Hits	105	Shared Neighborhood Hits	94
SwissProt Accessions	O54901, O54816, Q9JHD5	Gene names	Cd200, Mox2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (MRC OX-2 antigen) (CD200 antigen).

CD80_HUMAN
NC score	0.098292 (rank : 1170)	θ value	θ > 10 (rank : 1950)
Query Neighborhood Hits	1931	Target Neighborhood Hits	129	Shared Neighborhood Hits	110
SwissProt Accessions	P33681	Gene names	CD80, CD28LG, CD28LG1, LAB7
Domain Architecture
Description	T-lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1).

FGD1_HUMAN
NC score	0.098222 (rank : 1171)	θ value	0.00175202 (rank : 995)
Query Neighborhood Hits	1931	Target Neighborhood Hits	367	Shared Neighborhood Hits	133
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FCG2A_HUMAN
NC score	0.098198 (rank : 1172)	θ value	0.000270298 (rank : 950)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	84
SwissProt Accessions	P12318	Gene names	FCGR2A, CD32, FCG2, IGFR2
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II-a precursor (Fc-gamma RII-a) (FcRII-a) (IgG Fc receptor II-a) (Fc-gamma-RIIa) (CD32 antigen) (CDw32).

COEA1_MOUSE
NC score	0.098006 (rank : 1173)	θ value	θ > 10 (rank : 1958)
Query Neighborhood Hits	1931	Target Neighborhood Hits	402	Shared Neighborhood Hits	183
SwissProt Accessions	Q80X19, Q8C6X3, Q9WV05	Gene names	Col14a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor.

STAC_MOUSE
NC score	0.097600 (rank : 1174)	θ value	θ > 10 (rank : 2050)
Query Neighborhood Hits	1931	Target Neighborhood Hits	268	Shared Neighborhood Hits	108
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

BUB1B_HUMAN
NC score	0.096215 (rank : 1175)	θ value	θ > 10 (rank : 1942)
Query Neighborhood Hits	1931	Target Neighborhood Hits	208	Shared Neighborhood Hits	120
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

SLAP2_HUMAN
NC score	0.095468 (rank : 1176)	θ value	θ > 10 (rank : 2041)
Query Neighborhood Hits	1931	Target Neighborhood Hits	139	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

GRP3_HUMAN
NC score	0.095452 (rank : 1177)	θ value	θ > 10 (rank : 1981)
Query Neighborhood Hits	1931	Target Neighborhood Hits	131	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

STAC3_MOUSE
NC score	0.095404 (rank : 1178)	θ value	θ > 10 (rank : 2048)
Query Neighborhood Hits	1931	Target Neighborhood Hits	232	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.094544 (rank : 1179)	θ value	θ > 10 (rank : 2047)
Query Neighborhood Hits	1931	Target Neighborhood Hits	228	Shared Neighborhood Hits	97
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

PDL2_HUMAN
NC score	0.093956 (rank : 1180)	θ value	θ > 10 (rank : 2016)
Query Neighborhood Hits	1931	Target Neighborhood Hits	114	Shared Neighborhood Hits	91
SwissProt Accessions	Q9BQ51, Q5T7Z6, Q6JXL8, Q6JXL9	Gene names	PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 2 precursor (Programmed death ligand 2) (PD-L2) (PD-1-ligand 2) (PDCD1 ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD273 antigen).

SLAP1_HUMAN
NC score	0.093926 (rank : 1181)	θ value	θ > 10 (rank : 2039)
Query Neighborhood Hits	1931	Target Neighborhood Hits	113	Shared Neighborhood Hits	44
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SHPS1_HUMAN
NC score	0.093517 (rank : 1182)	θ value	0.0736092 (rank : 1154)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	159
SwissProt Accessions	P78324, O00683, O43799, Q8N517, Q8TAL8, Q9H0Z2, Q9UDX2, Q9UIJ6, Q9Y4U9	Gene names	SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (Sirp-alpha-2) (Sirp-alpha- 3) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (Macrophage fusion receptor) (p84) (CD172a antigen).

FPRP_HUMAN
NC score	0.093117 (rank : 1183)	θ value	1.38821 (rank : 1450)
Query Neighborhood Hits	1931	Target Neighborhood Hits	130	Shared Neighborhood Hits	111
SwissProt Accessions	Q9P2B2, Q8N2K6	Gene names	PTGFRN, CD9P1, FPRP, KIAA1436
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD9 partner 1) (CD9P-1) (CD315 antigen).

CO7A1_HUMAN
NC score	0.092667 (rank : 1184)	θ value	0.0330416 (rank : 1093)
Query Neighborhood Hits	1931	Target Neighborhood Hits	807	Shared Neighborhood Hits	293
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

SLAP1_MOUSE
NC score	0.092593 (rank : 1185)	θ value	θ > 10 (rank : 2040)
Query Neighborhood Hits	1931	Target Neighborhood Hits	117	Shared Neighborhood Hits	45
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

STAC_HUMAN
NC score	0.092260 (rank : 1186)	θ value	θ > 10 (rank : 2049)
Query Neighborhood Hits	1931	Target Neighborhood Hits	276	Shared Neighborhood Hits	108
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MFAP3_MOUSE
NC score	0.092004 (rank : 1187)	θ value	0.0330416 (rank : 1101)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	89
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

MFAP3_HUMAN
NC score	0.091942 (rank : 1188)	θ value	0.813845 (rank : 1381)
Query Neighborhood Hits	1931	Target Neighborhood Hits	91	Shared Neighborhood Hits	84
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

PTPRT_MOUSE
NC score	0.091699 (rank : 1189)	θ value	1.06291 (rank : 1420)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	123
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

FGD6_MOUSE
NC score	0.091684 (rank : 1190)	θ value	4.92598e-06 (rank : 854)
Query Neighborhood Hits	1931	Target Neighborhood Hits	282	Shared Neighborhood Hits	89
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ICAM1_MOUSE
NC score	0.091632 (rank : 1191)	θ value	θ > 10 (rank : 1988)
Query Neighborhood Hits	1931	Target Neighborhood Hits	99	Shared Neighborhood Hits	88
SwissProt Accessions	P13597, Q61828	Gene names	Icam1, Icam-1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (MALA-2).

PTPRU_HUMAN
NC score	0.091113 (rank : 1192)	θ value	3.0926 (rank : 1613)
Query Neighborhood Hits	1931	Target Neighborhood Hits	237	Shared Neighborhood Hits	139
SwissProt Accessions	Q92729	Gene names	PTPRU, PCP2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase U precursor (EC 3.1.3.48) (R-PTP-U) (Protein-tyrosine phosphatase J) (PTP-J) (Pancreatic carcinoma phosphatase 2) (PCP-2).

PTPRT_HUMAN
NC score	0.090986 (rank : 1193)	θ value	0.813845 (rank : 1388)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	121
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

CD79A_HUMAN
NC score	0.089185 (rank : 1194)	θ value	θ > 10 (rank : 1949)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	71
SwissProt Accessions	P11912	Gene names	CD79A, IGA, MB1
Domain Architecture
Description	B-cell antigen receptor complex-associated protein alpha-chain precursor (Ig-alpha) (MB-1 membrane glycoprotein) (Surface IgM- associated protein) (Membrane-bound immunoglobulin-associated protein) (CD79a antigen).

DNMBP_HUMAN
NC score	0.088773 (rank : 1195)	θ value	2.36792 (rank : 1540)
Query Neighborhood Hits	1931	Target Neighborhood Hits	413	Shared Neighborhood Hits	122
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FGD6_HUMAN
NC score	0.087676 (rank : 1196)	θ value	1.43324e-05 (rank : 876)
Query Neighborhood Hits	1931	Target Neighborhood Hits	237	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

GRAP_HUMAN
NC score	0.087553 (rank : 1197)	θ value	θ > 10 (rank : 1977)
Query Neighborhood Hits	1931	Target Neighborhood Hits	307	Shared Neighborhood Hits	92
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

TENR_HUMAN
NC score	0.087121 (rank : 1198)	θ value	0.365318 (rank : 1292)
Query Neighborhood Hits	1931	Target Neighborhood Hits	526	Shared Neighborhood Hits	151
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

GRAP_MOUSE
NC score	0.086454 (rank : 1199)	θ value	θ > 10 (rank : 1978)
Query Neighborhood Hits	1931	Target Neighborhood Hits	309	Shared Neighborhood Hits	90
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CSF3R_HUMAN
NC score	0.086073 (rank : 1200)	θ value	8.99809 (rank : 1842)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	95
SwissProt Accessions	Q99062	Gene names	CSF3R, GCSFR
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

ITSN2_HUMAN
NC score	0.085938 (rank : 1201)	θ value	0.0961366 (rank : 1174)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1173	Shared Neighborhood Hits	185
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

DNMBP_MOUSE
NC score	0.085274 (rank : 1202)	θ value	3.0926 (rank : 1587)
Query Neighborhood Hits	1931	Target Neighborhood Hits	435	Shared Neighborhood Hits	137
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ICAM1_HUMAN
NC score	0.085241 (rank : 1203)	θ value	5.27518 (rank : 1718)
Query Neighborhood Hits	1931	Target Neighborhood Hits	80	Shared Neighborhood Hits	69
SwissProt Accessions	P05362, Q96B50	Gene names	ICAM1
Domain Architecture
Description	Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen).

OX2G_HUMAN
NC score	0.085125 (rank : 1204)	θ value	θ > 10 (rank : 2011)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3	Gene names	CD200, MOX2
Domain Architecture
Description	OX-2 membrane glycoprotein precursor (CD200 antigen).

ARHG8_HUMAN
NC score	0.085005 (rank : 1205)	θ value	1.87187e-05 (rank : 882)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

TENN_MOUSE
NC score	0.084729 (rank : 1206)	θ value	θ > 10 (rank : 2054)
Query Neighborhood Hits	1931	Target Neighborhood Hits	484	Shared Neighborhood Hits	140
SwissProt Accessions	Q80Z71	Gene names	Tnn
Domain Architecture
Description	Tenascin-N precursor (TN-N).

PTPRK_MOUSE
NC score	0.084186 (rank : 1207)	θ value	θ > 10 (rank : 2023)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	131
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

SIRB1_HUMAN
NC score	0.084145 (rank : 1208)	θ value	0.125558 (rank : 1197)
Query Neighborhood Hits	1931	Target Neighborhood Hits	422	Shared Neighborhood Hits	147
SwissProt Accessions	O00241, Q5TFR0, Q8TB12, Q9H1U5, Q9Y4V0	Gene names	SIRPB1
Domain Architecture
Description	Signal-regulatory protein beta-1 precursor (SIRP-beta-1) (CD172b antigen).

TENR_MOUSE
NC score	0.083707 (rank : 1209)	θ value	0.62314 (rank : 1356)
Query Neighborhood Hits	1931	Target Neighborhood Hits	531	Shared Neighborhood Hits	146
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

COEA1_HUMAN
NC score	0.083306 (rank : 1210)	θ value	θ > 10 (rank : 1957)
Query Neighborhood Hits	1931	Target Neighborhood Hits	427	Shared Neighborhood Hits	196
SwissProt Accessions	Q05707, O00260, O00261, O00262, Q05708, Q5XJ18, Q96C67	Gene names	COL14A1, UND
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XIV) chain precursor (Undulin).

PTPRK_HUMAN
NC score	0.083040 (rank : 1211)	θ value	θ > 10 (rank : 2022)
Query Neighborhood Hits	1931	Target Neighborhood Hits	228	Shared Neighborhood Hits	131
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

GRAP2_HUMAN
NC score	0.082961 (rank : 1212)	θ value	θ > 10 (rank : 1975)
Query Neighborhood Hits	1931	Target Neighborhood Hits	304	Shared Neighborhood Hits	85
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRB2_HUMAN
NC score	0.082877 (rank : 1213)	θ value	θ > 10 (rank : 1979)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	87
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

FGD5_MOUSE
NC score	0.082842 (rank : 1214)	θ value	2.36244e-08 (rank : 728)
Query Neighborhood Hits	1931	Target Neighborhood Hits	170	Shared Neighborhood Hits	44
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

GRB2_MOUSE
NC score	0.082821 (rank : 1215)	θ value	θ > 10 (rank : 1980)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	87
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

FPRP_MOUSE
NC score	0.082676 (rank : 1216)	θ value	1.81305 (rank : 1495)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	90
SwissProt Accessions	Q9WV91	Gene names	Ptgfrn, Fprp
Domain Architecture
Description	Prostaglandin F2 receptor negative regulator precursor (Prostaglandin F2-alpha receptor regulatory protein) (Prostaglandin F2-alpha receptor-associated protein) (CD315 antigen).

FGD5_HUMAN
NC score	0.082596 (rank : 1217)	θ value	1.69304e-06 (rank : 825)
Query Neighborhood Hits	1931	Target Neighborhood Hits	235	Shared Neighborhood Hits	53
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

GRAP2_MOUSE
NC score	0.081714 (rank : 1218)	θ value	θ > 10 (rank : 1976)
Query Neighborhood Hits	1931	Target Neighborhood Hits	297	Shared Neighborhood Hits	84
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ARHG8_MOUSE
NC score	0.081460 (rank : 1219)	θ value	6.43352e-06 (rank : 859)
Query Neighborhood Hits	1931	Target Neighborhood Hits	79	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_MOUSE
NC score	0.081426 (rank : 1220)	θ value	0.0431538 (rank : 1112)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	62
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ITSN1_MOUSE
NC score	0.080679 (rank : 1221)	θ value	0.163984 (rank : 1213)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1669	Shared Neighborhood Hits	255
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

SIGIR_MOUSE
NC score	0.080632 (rank : 1222)	θ value	0.0193708 (rank : 1072)
Query Neighborhood Hits	1931	Target Neighborhood Hits	95	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

ITSN1_HUMAN
NC score	0.080442 (rank : 1223)	θ value	0.163984 (rank : 1212)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1757	Shared Neighborhood Hits	277
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ARHG3_HUMAN
NC score	0.079736 (rank : 1224)	θ value	0.163984 (rank : 1203)
Query Neighborhood Hits	1931	Target Neighborhood Hits	82	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ICAM3_HUMAN
NC score	0.079654 (rank : 1225)	θ value	θ > 10 (rank : 1989)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	85
SwissProt Accessions	P32942	Gene names	ICAM3
Domain Architecture
Description	Intercellular adhesion molecule 3 precursor (ICAM-3) (ICAM-R) (CDw50) (CD50 antigen).

I11RB_MOUSE
NC score	0.079459 (rank : 1226)	θ value	0.00175202 (rank : 997)
Query Neighborhood Hits	1931	Target Neighborhood Hits	101	Shared Neighborhood Hits	70
SwissProt Accessions	P70225, O09074, Q78DW8	Gene names	Il11ra2
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-2 chain precursor (IL-11R-alpha-2) (Interleukin-11 receptor beta chain) (IL-11R-beta).

CD4_HUMAN
NC score	0.079217 (rank : 1227)	θ value	0.0961366 (rank : 1168)
Query Neighborhood Hits	1931	Target Neighborhood Hits	122	Shared Neighborhood Hits	68
SwissProt Accessions	P01730, Q4ZGK2, Q5U066	Gene names	CD4
Domain Architecture
Description	T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3).

ITSN2_MOUSE
NC score	0.078877 (rank : 1228)	θ value	1.38821 (rank : 1456)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1371	Shared Neighborhood Hits	203
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NCK1_HUMAN
NC score	0.078668 (rank : 1229)	θ value	θ > 10 (rank : 2005)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	84
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ARHG3_MOUSE
NC score	0.078497 (rank : 1230)	θ value	0.0736092 (rank : 1145)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	50
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

NCK2_HUMAN
NC score	0.078298 (rank : 1231)	θ value	θ > 10 (rank : 2006)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	85
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NACAM_MOUSE
NC score	0.077457 (rank : 1232)	θ value	0.000602161 (rank : 974)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1866	Shared Neighborhood Hits	447
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ECT2_MOUSE
NC score	0.077271 (rank : 1233)	θ value	θ > 10 (rank : 1971)
Query Neighborhood Hits	1931	Target Neighborhood Hits	98	Shared Neighborhood Hits	60
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

I11RA_MOUSE
NC score	0.077212 (rank : 1234)	θ value	0.00020696 (rank : 944)
Query Neighborhood Hits	1931	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q64385, Q6NSQ0	Gene names	Il11ra1, Etl2, Il11ra
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha-1 chain precursor (IL-11R-alpha-1) (IL- 11RA1) (IL-11R-alpha) (IL-11RA) (Enhancer trap locus homolog 2) (Etl- 2) (NR-1).

SORL_HUMAN
NC score	0.076355 (rank : 1235)	θ value	θ > 10 (rank : 2043)
Query Neighborhood Hits	1931	Target Neighborhood Hits	440	Shared Neighborhood Hits	126
SwissProt Accessions	Q92673, Q92856	Gene names	SORL1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (SorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11).

COKA1_HUMAN
NC score	0.076249 (rank : 1236)	θ value	2.36792 (rank : 1538)
Query Neighborhood Hits	1931	Target Neighborhood Hits	403	Shared Neighborhood Hits	181
SwissProt Accessions	Q9P218, Q4VXQ4, Q8WUT2, Q96CY9, Q9BQU6, Q9BQU7	Gene names	COL20A1, KIAA1510
Domain Architecture
Description	Collagen alpha-1(XX) chain precursor.

BUB1B_MOUSE
NC score	0.075957 (rank : 1237)	θ value	θ > 10 (rank : 1943)
Query Neighborhood Hits	1931	Target Neighborhood Hits	202	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

CT075_HUMAN
NC score	0.075826 (rank : 1238)	θ value	0.62314 (rank : 1332)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	129
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

ARHGA_HUMAN
NC score	0.075562 (rank : 1239)	θ value	θ > 10 (rank : 1937)
Query Neighborhood Hits	1931	Target Neighborhood Hits	187	Shared Neighborhood Hits	64
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_HUMAN
NC score	0.075488 (rank : 1240)	θ value	θ > 10 (rank : 1970)
Query Neighborhood Hits	1931	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SORL_MOUSE
NC score	0.075040 (rank : 1241)	θ value	θ > 10 (rank : 2044)
Query Neighborhood Hits	1931	Target Neighborhood Hits	439	Shared Neighborhood Hits	128
SwissProt Accessions	O88307, O54711, O70581	Gene names	Sorl1
Domain Architecture
Description	Sortilin-related receptor precursor (Sorting protein-related receptor containing LDLR class A repeats) (mSorLA) (SorLA-1) (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (Gp250).

I11RA_HUMAN
NC score	0.074398 (rank : 1242)	θ value	0.0252991 (rank : 1081)
Query Neighborhood Hits	1931	Target Neighborhood Hits	138	Shared Neighborhood Hits	82
SwissProt Accessions	Q14626, Q16542, Q7KYJ7	Gene names	IL11RA
Domain Architecture	No domain graphic available
Description	Interleukin-11 receptor alpha chain precursor (IL-11R-alpha) (IL- 11RA).

PDZD8_HUMAN
NC score	0.074172 (rank : 1243)	θ value	θ > 10 (rank : 2017)
Query Neighborhood Hits	1931	Target Neighborhood Hits	185	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

RGNEF_MOUSE
NC score	0.073407 (rank : 1244)	θ value	θ > 10 (rank : 2030)
Query Neighborhood Hits	1931	Target Neighborhood Hits	641	Shared Neighborhood Hits	151
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

PRRT3_HUMAN
NC score	0.073294 (rank : 1245)	θ value	0.000461057 (rank : 966)
Query Neighborhood Hits	1931	Target Neighborhood Hits	998	Shared Neighborhood Hits	341
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SIGL9_HUMAN
NC score	0.072621 (rank : 1246)	θ value	θ > 10 (rank : 2038)
Query Neighborhood Hits	1931	Target Neighborhood Hits	76	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y336, Q9BYI9	Gene names	SIGLEC9
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 9 precursor (Siglec-9) (Protein FOAP-9).

BTNL2_HUMAN
NC score	0.072525 (rank : 1247)	θ value	θ > 10 (rank : 1941)
Query Neighborhood Hits	1931	Target Neighborhood Hits	164	Shared Neighborhood Hits	123
SwissProt Accessions	Q9UIR0, O98261, Q5JYF9, Q5RIF8, Q5SP08, Q5SP09, Q5SRW3, Q5SRW4, Q5SU36, Q95HK0	Gene names	BTNL2
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 2 precursor (BTL-II).

TENN_HUMAN
NC score	0.072131 (rank : 1248)	θ value	θ > 10 (rank : 2053)
Query Neighborhood Hits	1931	Target Neighborhood Hits	453	Shared Neighborhood Hits	130
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

RASF1_MOUSE
NC score	0.071979 (rank : 1249)	θ value	θ > 10 (rank : 2029)
Query Neighborhood Hits	1931	Target Neighborhood Hits	74	Shared Neighborhood Hits	37
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

CHIO_HUMAN
NC score	0.071442 (rank : 1250)	θ value	θ > 10 (rank : 1955)
Query Neighborhood Hits	1931	Target Neighborhood Hits	220	Shared Neighborhood Hits	76
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_MOUSE
NC score	0.070794 (rank : 1251)	θ value	θ > 10 (rank : 1954)
Query Neighborhood Hits	1931	Target Neighborhood Hits	229	Shared Neighborhood Hits	79
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CD48_MOUSE
NC score	0.070776 (rank : 1252)	θ value	0.0431538 (rank : 1115)
Query Neighborhood Hits	1931	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	P18181, Q545K2	Gene names	Cd48, Bcm-1
Domain Architecture
Description	CD48 antigen precursor (MRC OX-45 surface antigen) (BCM1 surface antigen) (BLAST-1) (HM48-1) (sgp-60).

DGKD_HUMAN
NC score	0.070424 (rank : 1253)	θ value	θ > 10 (rank : 1967)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	98
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

CHIN_HUMAN
NC score	0.070068 (rank : 1254)	θ value	θ > 10 (rank : 1953)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

OGFR_HUMAN
NC score	0.070013 (rank : 1255)	θ value	0.0113563 (rank : 1058)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1582	Shared Neighborhood Hits	445
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

UN13A_HUMAN
NC score	0.069983 (rank : 1256)	θ value	θ > 10 (rank : 2057)
Query Neighborhood Hits	1931	Target Neighborhood Hits	285	Shared Neighborhood Hits	75
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

A1BG_HUMAN
NC score	0.069981 (rank : 1257)	θ value	0.000786445 (rank : 975)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	P04217, Q8IYJ6, Q96P39	Gene names	A1BG
Domain Architecture
Description	Alpha-1B-glycoprotein precursor (Alpha-1-B glycoprotein).

SRRM2_MOUSE
NC score	0.069927 (rank : 1258)	θ value	0.62314 (rank : 1354)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1470	Shared Neighborhood Hits	342
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

MOX2R_HUMAN
NC score	0.069524 (rank : 1259)	θ value	θ > 10 (rank : 2003)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	48
SwissProt Accessions	Q8TD46, Q8TD44, Q8TD45, Q8TD52	Gene names	CD200R1, CD200R, CRTR2, MOX2R, OX2R
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

LY9_MOUSE
NC score	0.069130 (rank : 1260)	θ value	5.27518 (rank : 1727)
Query Neighborhood Hits	1931	Target Neighborhood Hits	110	Shared Neighborhood Hits	80
SwissProt Accessions	Q01965, Q9ES29, Q9ES35, Q9ES36	Gene names	Ly9, Ly-9
Domain Architecture
Description	T-lymphocyte surface antigen Ly-9 precursor (Lymphocyte antigen 9) (Cell-surface molecule Ly-9).

CSF3R_MOUSE
NC score	0.069036 (rank : 1261)	θ value	4.03905 (rank : 1640)
Query Neighborhood Hits	1931	Target Neighborhood Hits	104	Shared Neighborhood Hits	71
SwissProt Accessions	P40223	Gene names	Csf3r, Csfgr
Domain Architecture
Description	Granulocyte colony-stimulating factor receptor precursor (G-CSF-R) (CD114 antigen).

TENX_HUMAN
NC score	0.068763 (rank : 1262)	θ value	1.06291 (rank : 1428)
Query Neighborhood Hits	1931	Target Neighborhood Hits	789	Shared Neighborhood Hits	193
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

FCG3B_HUMAN
NC score	0.068711 (rank : 1263)	θ value	θ > 10 (rank : 1973)
Query Neighborhood Hits	1931	Target Neighborhood Hits	67	Shared Neighborhood Hits	63
SwissProt Accessions	O75015	Gene names	FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-B precursor (IgG Fc receptor III-1) (Fc-gamma RIII-beta) (Fc-gamma RIIIb) (FcRIIIb) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16b antigen).

IGSF8_HUMAN
NC score	0.068464 (rank : 1264)	θ value	0.00390308 (rank : 1019)
Query Neighborhood Hits	1931	Target Neighborhood Hits	88	Shared Neighborhood Hits	49
SwissProt Accessions	Q969P0, Q8NG09, Q96DP4, Q9BTG9	Gene names	IGSF8, CD81P3, EWI2, KCT4
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (LIR-D1) (CD316 antigen).

JAML1_HUMAN
NC score	0.068168 (rank : 1265)	θ value	0.279714 (rank : 1253)
Query Neighborhood Hits	1931	Target Neighborhood Hits	108	Shared Neighborhood Hits	78
SwissProt Accessions	Q86YT9, Q5DTC6, Q7Z499, Q8N9I7, Q8NF70	Gene names	AMICA1, JAML
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule-like precursor (Dendritic cell-specific protein CREA7-1) (Adhesion molecule interacting with CXADR antigen 1).

SRRM1_MOUSE
NC score	0.068099 (rank : 1266)	θ value	θ > 10 (rank : 2046)
Query Neighborhood Hits	1931	Target Neighborhood Hits	966	Shared Neighborhood Hits	276
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

HCFC2_HUMAN
NC score	0.067829 (rank : 1267)	θ value	6.88961 (rank : 1777)
Query Neighborhood Hits	1931	Target Neighborhood Hits	154	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y5Z7	Gene names	HCFC2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

UN13B_HUMAN
NC score	0.067483 (rank : 1268)	θ value	θ > 10 (rank : 2058)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	63
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

DGKH_HUMAN
NC score	0.066974 (rank : 1269)	θ value	θ > 10 (rank : 1968)
Query Neighborhood Hits	1931	Target Neighborhood Hits	255	Shared Neighborhood Hits	91
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

ANKF1_HUMAN
NC score	0.066894 (rank : 1270)	θ value	6.88961 (rank : 1751)
Query Neighborhood Hits	1931	Target Neighborhood Hits	126	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

AMGO2_HUMAN
NC score	0.066883 (rank : 1271)	θ value	θ > 10 (rank : 1932)
Query Neighborhood Hits	1931	Target Neighborhood Hits	357	Shared Neighborhood Hits	137
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

PACE1_MOUSE
NC score	0.066386 (rank : 1272)	θ value	θ > 10 (rank : 2015)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	61
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

I18RA_HUMAN
NC score	0.066170 (rank : 1273)	θ value	0.0736092 (rank : 1150)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	70
SwissProt Accessions	O95256, Q53TT4, Q53TU5	Gene names	IL18RAP
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7) (CDw218b antigen).

SHPS1_MOUSE
NC score	0.066104 (rank : 1274)	θ value	0.0113563 (rank : 1059)
Query Neighborhood Hits	1931	Target Neighborhood Hits	439	Shared Neighborhood Hits	139
SwissProt Accessions	P97797, O08907, O35924, O88555, O88556, P97796, Q8R559, Q9QX57, Q9WTN4	Gene names	Sirpa, Bit, Myd1, Ptpns1, Shps1, Sirp
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type substrate 1 precursor (SHP substrate 1) (SHPS-1) (Inhibitory receptor SHPS-1) (Signal- regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (MyD-1 antigen) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (p84) (CD172a antigen).

DCX_HUMAN
NC score	0.066022 (rank : 1275)	θ value	θ > 10 (rank : 1965)
Query Neighborhood Hits	1931	Target Neighborhood Hits	141	Shared Neighborhood Hits	57
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

BSN_MOUSE
NC score	0.065958 (rank : 1276)	θ value	0.125558 (rank : 1186)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2057	Shared Neighborhood Hits	470
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

IL27B_HUMAN
NC score	0.065532 (rank : 1277)	θ value	θ > 10 (rank : 1993)
Query Neighborhood Hits	1931	Target Neighborhood Hits	80	Shared Neighborhood Hits	59
SwissProt Accessions	Q14213, O75269	Gene names	EBI3, IL27B
Domain Architecture
Description	Interleukin-27 beta chain precursor (IL-27B) (Epstein-Barr virus- induced gene 3 protein) (EBV-induced gene 3 protein).

UN13B_MOUSE
NC score	0.065258 (rank : 1278)	θ value	θ > 10 (rank : 2059)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

FCGR2_MOUSE
NC score	0.064305 (rank : 1279)	θ value	8.99809 (rank : 1850)
Query Neighborhood Hits	1931	Target Neighborhood Hits	105	Shared Neighborhood Hits	71
SwissProt Accessions	P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558	Gene names	Fcgr2, Fcgr2b, Ly-17
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor II precursor (Fc- gamma RII) (FcRII) (IgG Fc receptor II beta) (Fc gamma receptor IIB) (Fc-gamma-RIIB) (Lymphocyte antigen Ly-17) (CD32 antigen).

CHIO_MOUSE
NC score	0.064283 (rank : 1280)	θ value	θ > 10 (rank : 1956)
Query Neighborhood Hits	1931	Target Neighborhood Hits	130	Shared Neighborhood Hits	49
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SRRM2_HUMAN
NC score	0.064154 (rank : 1281)	θ value	0.0148317 (rank : 1067)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1296	Shared Neighborhood Hits	287
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SH21B_MOUSE
NC score	0.064109 (rank : 1282)	θ value	θ > 10 (rank : 2037)
Query Neighborhood Hits	1931	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

I18RA_MOUSE
NC score	0.064061 (rank : 1283)	θ value	1.38821 (rank : 1453)
Query Neighborhood Hits	1931	Target Neighborhood Hits	93	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Z2B1	Gene names	Il18rap
Domain Architecture	No domain graphic available
Description	Interleukin-18 receptor accessory protein precursor (IL-18 receptor accessory protein) (IL-18RAcP) (Interleukin-18 receptor accessory protein-like) (IL-18Rbeta) (IL-1R accessory protein-like) (IL-1RAcPL) (Accessory protein-like) (AcPL) (IL-1R7).

SIRPG_HUMAN
NC score	0.063985 (rank : 1284)	θ value	1.38821 (rank : 1467)
Query Neighborhood Hits	1931	Target Neighborhood Hits	359	Shared Neighborhood Hits	119
SwissProt Accessions	Q9P1W8, Q8WWA5, Q9NQK8	Gene names	SIRPG, SIRPB2
Domain Architecture
Description	Signal-regulatory protein gamma precursor (Signal-regulatory protein beta-2) (SIRP-beta-2) (SIRP-b2) (CD172g antigen).

IL6RA_MOUSE
NC score	0.063854 (rank : 1285)	θ value	0.813845 (rank : 1377)
Query Neighborhood Hits	1931	Target Neighborhood Hits	104	Shared Neighborhood Hits	74
SwissProt Accessions	P22272	Gene names	Il6ra, Il6r
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (CD126 antigen).

PACE1_HUMAN
NC score	0.063837 (rank : 1286)	θ value	θ > 10 (rank : 2014)
Query Neighborhood Hits	1931	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

FCG3A_HUMAN
NC score	0.063819 (rank : 1287)	θ value	3.0926 (rank : 1591)
Query Neighborhood Hits	1931	Target Neighborhood Hits	65	Shared Neighborhood Hits	61
SwissProt Accessions	P08637	Gene names	FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III-A precursor (IgG Fc receptor III-2) (Fc-gamma RIII-alpha) (Fc-gamma RIIIa) (FcRIIIa) (Fc-gamma RIII) (FcRIII) (FcR-10) (CD16a antigen).

TPSNR_HUMAN
NC score	0.063794 (rank : 1288)	θ value	0.365318 (rank : 1293)
Query Neighborhood Hits	1931	Target Neighborhood Hits	330	Shared Neighborhood Hits	136
SwissProt Accessions	Q9BX59, Q9NWB8	Gene names	TAPBPL
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

I12R1_HUMAN
NC score	0.063387 (rank : 1289)	θ value	θ > 10 (rank : 1984)
Query Neighborhood Hits	1931	Target Neighborhood Hits	78	Shared Neighborhood Hits	56
SwissProt Accessions	P42701	Gene names	IL12RB1, IL12R, IL12RB
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (IL- 12RB1) (CD212 antigen).

RIMB2_HUMAN
NC score	0.063275 (rank : 1290)	θ value	θ > 10 (rank : 2031)
Query Neighborhood Hits	1931	Target Neighborhood Hits	263	Shared Neighborhood Hits	98
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ARHG5_HUMAN
NC score	0.062937 (rank : 1291)	θ value	2.36792 (rank : 1523)
Query Neighborhood Hits	1931	Target Neighborhood Hits	172	Shared Neighborhood Hits	68
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

DGKQ_HUMAN
NC score	0.062859 (rank : 1292)	θ value	θ > 10 (rank : 1969)
Query Neighborhood Hits	1931	Target Neighborhood Hits	131	Shared Neighborhood Hits	48
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

BSN_HUMAN
NC score	0.062814 (rank : 1293)	θ value	0.00228821 (rank : 999)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1537	Shared Neighborhood Hits	370
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CEAMA_MOUSE
NC score	0.062183 (rank : 1294)	θ value	θ > 10 (rank : 1952)
Query Neighborhood Hits	1931	Target Neighborhood Hits	41	Shared Neighborhood Hits	35
SwissProt Accessions	Q61400, Q99LD6, Q9D329	Gene names	Ceacam10, Cea10
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 10 precursor (CEA-related cell adhesion molecule 10) (Carcinoembryonic antigen 10) (CEA10).

DCX_MOUSE
NC score	0.061641 (rank : 1295)	θ value	θ > 10 (rank : 1966)
Query Neighborhood Hits	1931	Target Neighborhood Hits	124	Shared Neighborhood Hits	36
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

ARHGG_HUMAN
NC score	0.061641 (rank : 1296)	θ value	θ > 10 (rank : 1939)
Query Neighborhood Hits	1931	Target Neighborhood Hits	129	Shared Neighborhood Hits	63
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

IGSF8_MOUSE
NC score	0.061612 (rank : 1297)	θ value	0.00390308 (rank : 1020)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	54
SwissProt Accessions	Q8R366, Q8R0L7	Gene names	Igsf8, Ewi2, Kct4, Pgrl
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 8 precursor (CD81 partner 3) (Glu- Trp-Ile EWI motif-containing protein 2) (EWI-2) (Keratinocytes- associated transmembrane protein 4) (KCT-4) (Prostaglandin regulatory- like protein) (CD316 antigen).

IL1AP_MOUSE
NC score	0.061515 (rank : 1298)	θ value	θ > 10 (rank : 1992)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	62
SwissProt Accessions	Q61730, Q8VCB9	Gene names	Il1rap
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

CEAM3_HUMAN
NC score	0.061107 (rank : 1299)	θ value	θ > 10 (rank : 1951)
Query Neighborhood Hits	1931	Target Neighborhood Hits	28	Shared Neighborhood Hits	23
SwissProt Accessions	P40198	Gene names	CEACAM3, CD66D, CGM1
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 3 precursor (Carcinoembryonic antigen CGM1) (CD66d antigen).

TPSNR_MOUSE
NC score	0.060957 (rank : 1300)	θ value	θ > 10 (rank : 2056)
Query Neighborhood Hits	1931	Target Neighborhood Hits	336	Shared Neighborhood Hits	141
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

ARHGF_HUMAN
NC score	0.060684 (rank : 1301)	θ value	1.81305 (rank : 1480)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	111
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

NGEF_MOUSE
NC score	0.060583 (rank : 1302)	θ value	θ > 10 (rank : 2008)
Query Neighborhood Hits	1931	Target Neighborhood Hits	228	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

IL6RA_HUMAN
NC score	0.059724 (rank : 1303)	θ value	0.0736092 (rank : 1151)
Query Neighborhood Hits	1931	Target Neighborhood Hits	96	Shared Neighborhood Hits	63
SwissProt Accessions	P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23	Gene names	IL6R
Domain Architecture
Description	Interleukin-6 receptor alpha chain precursor (IL-6R-alpha) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD126 antigen).

CT075_MOUSE
NC score	0.059544 (rank : 1304)	θ value	θ > 10 (rank : 1962)
Query Neighborhood Hits	1931	Target Neighborhood Hits	358	Shared Neighborhood Hits	108
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

RIMB2_MOUSE
NC score	0.059470 (rank : 1305)	θ value	θ > 10 (rank : 2032)
Query Neighborhood Hits	1931	Target Neighborhood Hits	246	Shared Neighborhood Hits	89
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

FCERA_MOUSE
NC score	0.059382 (rank : 1306)	θ value	4.03905 (rank : 1650)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	50
SwissProt Accessions	P20489	Gene names	Fcer1a, Fce1a
Domain Architecture
Description	High affinity immunoglobulin epsilon receptor alpha-subunit precursor (FcERI) (IgE Fc receptor, alpha-subunit) (Fc-epsilon RI-alpha).

LCP2_HUMAN
NC score	0.059010 (rank : 1307)	θ value	0.163984 (rank : 1215)
Query Neighborhood Hits	1931	Target Neighborhood Hits	531	Shared Neighborhood Hits	194
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PCLO_MOUSE
NC score	0.058877 (rank : 1308)	θ value	0.00665767 (rank : 1041)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2275	Shared Neighborhood Hits	469
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

SH21A_MOUSE
NC score	0.058460 (rank : 1309)	θ value	θ > 10 (rank : 2035)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	40
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

RASF1_HUMAN
NC score	0.058220 (rank : 1310)	θ value	θ > 10 (rank : 2028)
Query Neighborhood Hits	1931	Target Neighborhood Hits	62	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

BT3A2_HUMAN
NC score	0.058004 (rank : 1311)	θ value	8.99809 (rank : 1829)
Query Neighborhood Hits	1931	Target Neighborhood Hits	158	Shared Neighborhood Hits	107
SwissProt Accessions	P78410, O00477, O15338, O75658, Q76PA0, Q9BU81, Q9NR44	Gene names	BTN3A2, BT3.2, BTF3, BTF4
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A2 precursor.

FARP2_HUMAN
NC score	0.057958 (rank : 1312)	θ value	3.0926 (rank : 1590)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	88
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

RGS3_MOUSE
NC score	0.057918 (rank : 1313)	θ value	0.813845 (rank : 1391)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1621	Shared Neighborhood Hits	433
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

FARP2_MOUSE
NC score	0.057891 (rank : 1314)	θ value	θ > 10 (rank : 1972)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHGB_HUMAN
NC score	0.057835 (rank : 1315)	θ value	5.27518 (rank : 1698)
Query Neighborhood Hits	1931	Target Neighborhood Hits	375	Shared Neighborhood Hits	108
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

AMGO2_MOUSE
NC score	0.057794 (rank : 1316)	θ value	θ > 10 (rank : 1933)
Query Neighborhood Hits	1931	Target Neighborhood Hits	329	Shared Neighborhood Hits	108
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

ARHGG_MOUSE
NC score	0.057608 (rank : 1317)	θ value	θ > 10 (rank : 1940)
Query Neighborhood Hits	1931	Target Neighborhood Hits	152	Shared Neighborhood Hits	59
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

NGEF_HUMAN
NC score	0.057487 (rank : 1318)	θ value	θ > 10 (rank : 2007)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

RASA1_HUMAN
NC score	0.057479 (rank : 1319)	θ value	θ > 10 (rank : 2027)
Query Neighborhood Hits	1931	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21B_HUMAN
NC score	0.057410 (rank : 1320)	θ value	θ > 10 (rank : 2036)
Query Neighborhood Hits	1931	Target Neighborhood Hits	101	Shared Neighborhood Hits	41
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

AMGO1_HUMAN
NC score	0.057155 (rank : 1321)	θ value	0.0736092 (rank : 1144)
Query Neighborhood Hits	1931	Target Neighborhood Hits	353	Shared Neighborhood Hits	118
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

CRKL_MOUSE
NC score	0.057117 (rank : 1322)	θ value	θ > 10 (rank : 1960)
Query Neighborhood Hits	1931	Target Neighborhood Hits	307	Shared Neighborhood Hits	84
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.056709 (rank : 1323)	θ value	θ > 10 (rank : 1959)
Query Neighborhood Hits	1931	Target Neighborhood Hits	313	Shared Neighborhood Hits	88
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

NCOA6_HUMAN
NC score	0.056537 (rank : 1324)	θ value	0.125558 (rank : 1192)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1202	Shared Neighborhood Hits	357
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

SON_HUMAN
NC score	0.056502 (rank : 1325)	θ value	1.06291 (rank : 1426)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1568	Shared Neighborhood Hits	407
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

GP116_HUMAN
NC score	0.056468 (rank : 1326)	θ value	0.00175202 (rank : 996)
Query Neighborhood Hits	1931	Target Neighborhood Hits	167	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IZF2, O94858, Q6RGN2, Q86SP0, Q9Y3Z2	Gene names	GPR116, KIAA0758
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 116 precursor.

ARHG2_MOUSE
NC score	0.056137 (rank : 1327)	θ value	θ > 10 (rank : 1936)
Query Neighborhood Hits	1931	Target Neighborhood Hits	120	Shared Neighborhood Hits	66
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

RGS3_HUMAN
NC score	0.056105 (rank : 1328)	θ value	0.00509761 (rank : 1035)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1375	Shared Neighborhood Hits	381
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TENA_HUMAN
NC score	0.055524 (rank : 1329)	θ value	θ > 10 (rank : 2052)
Query Neighborhood Hits	1931	Target Neighborhood Hits	631	Shared Neighborhood Hits	141
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

ARHG2_HUMAN
NC score	0.055363 (rank : 1330)	θ value	θ > 10 (rank : 1935)
Query Neighborhood Hits	1931	Target Neighborhood Hits	142	Shared Neighborhood Hits	73
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

TMM25_HUMAN
NC score	0.055064 (rank : 1331)	θ value	8.99809 (rank : 1920)
Query Neighborhood Hits	1931	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q86YD3, Q6UW89, Q86UA7, Q96KA6, Q96MW9	Gene names	TMEM25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

PCLO_HUMAN
NC score	0.054974 (rank : 1332)	θ value	4.03905 (rank : 1671)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2046	Shared Neighborhood Hits	413
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

CD48_HUMAN
NC score	0.054814 (rank : 1333)	θ value	θ > 10 (rank : 1948)
Query Neighborhood Hits	1931	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	P09326	Gene names	CD48, BCM1, BLAST1
Domain Architecture	No domain graphic available
Description	CD48 antigen precursor (B-lymphocyte activation marker BLAST-1) (BCM1 surface antigen) (Leukocyte antigen MEM-102) (TCT.1).

BAT2_HUMAN
NC score	0.054623 (rank : 1334)	θ value	0.0148317 (rank : 1061)
Query Neighborhood Hits	1931	Target Neighborhood Hits	931	Shared Neighborhood Hits	277
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

PRP2_MOUSE
NC score	0.054617 (rank : 1335)	θ value	0.0431538 (rank : 1123)
Query Neighborhood Hits	1931	Target Neighborhood Hits	347	Shared Neighborhood Hits	124
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

FCGR3_MOUSE
NC score	0.054617 (rank : 1336)	θ value	θ > 10 (rank : 1974)
Query Neighborhood Hits	1931	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	P08508	Gene names	Fcgr3
Domain Architecture
Description	Low affinity immunoglobulin gamma Fc region receptor III precursor (IgG Fc receptor III) (Fc-gamma RIII) (FcRIII).

CD226_HUMAN
NC score	0.054544 (rank : 1337)	θ value	θ > 10 (rank : 1945)
Query Neighborhood Hits	1931	Target Neighborhood Hits	87	Shared Neighborhood Hits	72
SwissProt Accessions	Q15762	Gene names	CD226, DNAM1
Domain Architecture
Description	CD226 antigen precursor (DNAX accessory molecule 1) (DNAM-1).

TMM25_MOUSE
NC score	0.054532 (rank : 1338)	θ value	θ > 10 (rank : 2055)
Query Neighborhood Hits	1931	Target Neighborhood Hits	46	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DCF1, Q3TMP3, Q6PAK7	Gene names	Tmem25
Domain Architecture	No domain graphic available
Description	Transmembrane protein 25 precursor.

IL18R_MOUSE
NC score	0.054041 (rank : 1339)	θ value	0.0563607 (rank : 1132)
Query Neighborhood Hits	1931	Target Neighborhood Hits	82	Shared Neighborhood Hits	47
SwissProt Accessions	Q61098	Gene names	Il18r1
Domain Architecture
Description	Interleukin-18 receptor 1 precursor (IL1 receptor-related protein) (IL-1Rrp).

SH21A_HUMAN
NC score	0.054023 (rank : 1340)	θ value	θ > 10 (rank : 2034)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	39
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

ABR_HUMAN
NC score	0.053799 (rank : 1341)	θ value	0.000602161 (rank : 969)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

AMGO3_HUMAN
NC score	0.053284 (rank : 1342)	θ value	θ > 10 (rank : 1934)
Query Neighborhood Hits	1931	Target Neighborhood Hits	276	Shared Neighborhood Hits	84
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

PLCG1_MOUSE
NC score	0.053036 (rank : 1343)	θ value	θ > 10 (rank : 2019)
Query Neighborhood Hits	1931	Target Neighborhood Hits	314	Shared Neighborhood Hits	84
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

FARP1_HUMAN
NC score	0.053032 (rank : 1344)	θ value	0.00228821 (rank : 1000)
Query Neighborhood Hits	1931	Target Neighborhood Hits	241	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

AMGO3_MOUSE
NC score	0.052894 (rank : 1345)	θ value	0.163984 (rank : 1201)
Query Neighborhood Hits	1931	Target Neighborhood Hits	276	Shared Neighborhood Hits	81
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

PLCG1_HUMAN
NC score	0.052613 (rank : 1346)	θ value	θ > 10 (rank : 2018)
Query Neighborhood Hits	1931	Target Neighborhood Hits	293	Shared Neighborhood Hits	82
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MUC1_HUMAN
NC score	0.052405 (rank : 1347)	θ value	θ > 10 (rank : 2004)
Query Neighborhood Hits	1931	Target Neighborhood Hits	975	Shared Neighborhood Hits	327
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

DAPP1_HUMAN
NC score	0.051950 (rank : 1348)	θ value	θ > 10 (rank : 1963)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

IASPP_MOUSE
NC score	0.051619 (rank : 1349)	θ value	6.88961 (rank : 1783)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1024	Shared Neighborhood Hits	315
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

BTNL1_MOUSE
NC score	0.051486 (rank : 1350)	θ value	4.03905 (rank : 1626)
Query Neighborhood Hits	1931	Target Neighborhood Hits	151	Shared Neighborhood Hits	105
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

IL1AP_HUMAN
NC score	0.051307 (rank : 1351)	θ value	θ > 10 (rank : 1991)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NPH3, O14915, Q86WJ7	Gene names	IL1RAP
Domain Architecture
Description	Interleukin-1 receptor accessory protein precursor (IL-1 receptor accessory protein) (IL-1RAcP).

ARHGC_HUMAN
NC score	0.051015 (rank : 1352)	θ value	θ > 10 (rank : 1938)
Query Neighborhood Hits	1931	Target Neighborhood Hits	351	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

I12R1_MOUSE
NC score	0.050962 (rank : 1353)	θ value	θ > 10 (rank : 1985)
Query Neighborhood Hits	1931	Target Neighborhood Hits	70	Shared Neighborhood Hits	49
SwissProt Accessions	Q60837	Gene names	Il12rb1, Il12rb
Domain Architecture
Description	Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component) (CD212 antigen).

CD244_HUMAN
NC score	0.050874 (rank : 1354)	θ value	θ > 10 (rank : 1946)
Query Neighborhood Hits	1931	Target Neighborhood Hits	72	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BZW8, Q96T47, Q9NQD2, Q9NQD3, Q9Y288	Gene names	CD244, 2B4
Domain Architecture
Description	Natural killer cell receptor 2B4 precursor (NKR2B4) (NK cell type I receptor protein 2B4) (h2B4) (CD244 antigen) (NK cell activation- inducing ligand) (NAIL).

PRP1_HUMAN
NC score	0.050713 (rank : 1355)	θ value	0.163984 (rank : 1218)
Query Neighborhood Hits	1931	Target Neighborhood Hits	385	Shared Neighborhood Hits	143
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

DAPP1_MOUSE
NC score	0.050687 (rank : 1356)	θ value	θ > 10 (rank : 1964)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

MDC1_HUMAN
NC score	0.050621 (rank : 1357)	θ value	θ > 10 (rank : 2002)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1446	Shared Neighborhood Hits	315
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

ICOSL_MOUSE
NC score	0.050559 (rank : 1358)	θ value	θ > 10 (rank : 1990)
Query Neighborhood Hits	1931	Target Neighborhood Hits	93	Shared Neighborhood Hits	66
SwissProt Accessions	Q9JHJ8	Gene names	Icoslg, B7h2, B7rp1, Icosl
Domain Architecture
Description	ICOS ligand precursor (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (LICOS) (CD275 antigen).

CRLF1_HUMAN
NC score	0.050280 (rank : 1359)	θ value	θ > 10 (rank : 1961)
Query Neighborhood Hits	1931	Target Neighborhood Hits	122	Shared Neighborhood Hits	73
SwissProt Accessions	O75462, Q9UHH5	Gene names	CRLF1, ZCYTOR5
Domain Architecture
Description	Cytokine receptor-like factor 1 precursor (Cytokine-like factor 1) (CLF-1) (ZcytoR5).

SRRM1_HUMAN
NC score	0.050255 (rank : 1360)	θ value	θ > 10 (rank : 2045)
Query Neighborhood Hits	1931	Target Neighborhood Hits	690	Shared Neighborhood Hits	180
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

BT1A1_MOUSE
NC score	0.050159 (rank : 1361)	θ value	0.0961366 (rank : 1167)
Query Neighborhood Hits	1931	Target Neighborhood Hits	252	Shared Neighborhood Hits	136
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

P85B_MOUSE
NC score	0.050032 (rank : 1362)	θ value	θ > 10 (rank : 2013)
Query Neighborhood Hits	1931	Target Neighborhood Hits	519	Shared Neighborhood Hits	98
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

BAT2_MOUSE
NC score	0.049219 (rank : 1363)	θ value	0.0736092 (rank : 1146)
Query Neighborhood Hits	1931	Target Neighborhood Hits	947	Shared Neighborhood Hits	296
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

MDC1_MOUSE
NC score	0.049148 (rank : 1364)	θ value	0.21417 (rank : 1236)
Query Neighborhood Hits	1931	Target Neighborhood Hits	998	Shared Neighborhood Hits	262
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

BCR_HUMAN
NC score	0.048887 (rank : 1365)	θ value	0.279714 (rank : 1244)
Query Neighborhood Hits	1931	Target Neighborhood Hits	204	Shared Neighborhood Hits	72
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

AMGO1_MOUSE
NC score	0.048812 (rank : 1366)	θ value	0.0148317 (rank : 1060)
Query Neighborhood Hits	1931	Target Neighborhood Hits	325	Shared Neighborhood Hits	94
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

PRB4S_HUMAN
NC score	0.048160 (rank : 1367)	θ value	0.62314 (rank : 1344)
Query Neighborhood Hits	1931	Target Neighborhood Hits	330	Shared Neighborhood Hits	124
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

SOS1_HUMAN
NC score	0.047285 (rank : 1368)	θ value	0.00509761 (rank : 1036)
Query Neighborhood Hits	1931	Target Neighborhood Hits	274	Shared Neighborhood Hits	86
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

SOS1_MOUSE
NC score	0.046390 (rank : 1369)	θ value	0.0330416 (rank : 1104)
Query Neighborhood Hits	1931	Target Neighborhood Hits	281	Shared Neighborhood Hits	91
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TAF4_HUMAN
NC score	0.046248 (rank : 1370)	θ value	0.21417 (rank : 1241)
Query Neighborhood Hits	1931	Target Neighborhood Hits	687	Shared Neighborhood Hits	198
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

SOS2_HUMAN
NC score	0.045541 (rank : 1371)	θ value	0.0736092 (rank : 1155)
Query Neighborhood Hits	1931	Target Neighborhood Hits	193	Shared Neighborhood Hits	61
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

BT1A1_HUMAN
NC score	0.045344 (rank : 1372)	θ value	9.29e-05 (rank : 929)
Query Neighborhood Hits	1931	Target Neighborhood Hits	322	Shared Neighborhood Hits	133
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

SPR1B_MOUSE
NC score	0.045233 (rank : 1373)	θ value	0.0431538 (rank : 1124)
Query Neighborhood Hits	1931	Target Neighborhood Hits	395	Shared Neighborhood Hits	158
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

MBD6_HUMAN
NC score	0.045212 (rank : 1374)	θ value	0.365318 (rank : 1283)
Query Neighborhood Hits	1931	Target Neighborhood Hits	349	Shared Neighborhood Hits	131
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

PTPRJ_HUMAN
NC score	0.044997 (rank : 1375)	θ value	1.06291 (rank : 1419)
Query Neighborhood Hits	1931	Target Neighborhood Hits	207	Shared Neighborhood Hits	97
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

SIGIR_HUMAN
NC score	0.043859 (rank : 1376)	θ value	0.21417 (rank : 1239)
Query Neighborhood Hits	1931	Target Neighborhood Hits	53	Shared Neighborhood Hits	28
SwissProt Accessions	Q6IA17, Q3KQY2, Q6UXI3, Q9H733	Gene names	SIGIRR
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

TXND2_HUMAN
NC score	0.043645 (rank : 1377)	θ value	0.0961366 (rank : 1182)
Query Neighborhood Hits	1931	Target Neighborhood Hits	793	Shared Neighborhood Hits	169
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

SFPQ_HUMAN
NC score	0.043156 (rank : 1378)	θ value	0.0148317 (rank : 1066)
Query Neighborhood Hits	1931	Target Neighborhood Hits	986	Shared Neighborhood Hits	213
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

TARA_HUMAN
NC score	0.043051 (rank : 1379)	θ value	0.00228821 (rank : 1005)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1626	Shared Neighborhood Hits	340
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

RIMB1_HUMAN
NC score	0.042781 (rank : 1380)	θ value	5.27518 (rank : 1735)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1479	Shared Neighborhood Hits	290
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MADCA_HUMAN
NC score	0.042683 (rank : 1381)	θ value	0.62314 (rank : 1340)
Query Neighborhood Hits	1931	Target Neighborhood Hits	221	Shared Neighborhood Hits	78
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

STAM1_HUMAN
NC score	0.042619 (rank : 1382)	θ value	1.38821 (rank : 1471)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	78
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

BASP_MOUSE
NC score	0.042616 (rank : 1383)	θ value	1.06291 (rank : 1397)
Query Neighborhood Hits	1931	Target Neighborhood Hits	260	Shared Neighborhood Hits	74
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

GP125_MOUSE
NC score	0.042332 (rank : 1384)	θ value	0.62314 (rank : 1334)
Query Neighborhood Hits	1931	Target Neighborhood Hits	329	Shared Neighborhood Hits	80
SwissProt Accessions	Q7TT36, Q6PE67, Q8VE71	Gene names	Gpr125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

STAM1_MOUSE
NC score	0.042232 (rank : 1385)	θ value	2.36792 (rank : 1568)
Query Neighborhood Hits	1931	Target Neighborhood Hits	273	Shared Neighborhood Hits	77
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

MAGE1_HUMAN
NC score	0.042009 (rank : 1386)	θ value	0.163984 (rank : 1217)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1389	Shared Neighborhood Hits	385
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CD3E_MOUSE
NC score	0.041817 (rank : 1387)	θ value	1.38821 (rank : 1436)
Query Neighborhood Hits	1931	Target Neighborhood Hits	34	Shared Neighborhood Hits	23
SwissProt Accessions	P22646	Gene names	Cd3e
Domain Architecture
Description	T-cell surface glycoprotein CD3 epsilon chain precursor (T-cell surface antigen T3/Leu-4 epsilon chain).

NFH_MOUSE
NC score	0.041080 (rank : 1388)	θ value	1.87187e-05 (rank : 890)
Query Neighborhood Hits	1931	Target Neighborhood Hits	2247	Shared Neighborhood Hits	434
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CD79B_MOUSE
NC score	0.040815 (rank : 1389)	θ value	0.21417 (rank : 1225)
Query Neighborhood Hits	1931	Target Neighborhood Hits	150	Shared Neighborhood Hits	57
SwissProt Accessions	P15530	Gene names	Cd79b, Igb
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

IL12B_MOUSE
NC score	0.040767 (rank : 1390)	θ value	0.365318 (rank : 1280)
Query Neighborhood Hits	1931	Target Neighborhood Hits	43	Shared Neighborhood Hits	33
SwissProt Accessions	P43432, Q9QUM1	Gene names	Il12b
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40).

NEUG_HUMAN
NC score	0.040652 (rank : 1391)	θ value	0.125558 (rank : 1193)
Query Neighborhood Hits	1931	Target Neighborhood Hits	9	Shared Neighborhood Hits	7
SwissProt Accessions	Q92686	Gene names	NRGN
Domain Architecture	No domain graphic available
Description	Neurogranin (Ng) (RC3).

NCOR2_HUMAN
NC score	0.040137 (rank : 1392)	θ value	0.813845 (rank : 1384)
Query Neighborhood Hits	1931	Target Neighborhood Hits	870	Shared Neighborhood Hits	240
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

GP125_HUMAN
NC score	0.040126 (rank : 1393)	θ value	0.62314 (rank : 1333)
Query Neighborhood Hits	1931	Target Neighborhood Hits	327	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IWK6, Q6UXK9, Q86SQ5, Q8TC55	Gene names	GPR125
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 125 precursor.

GSCR1_HUMAN
NC score	0.040012 (rank : 1394)	θ value	2.36792 (rank : 1547)
Query Neighborhood Hits	1931	Target Neighborhood Hits	674	Shared Neighborhood Hits	200
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MARCS_MOUSE
NC score	0.039982 (rank : 1395)	θ value	0.0961366 (rank : 1176)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	65
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

NEUG_MOUSE
NC score	0.039882 (rank : 1396)	θ value	0.0961366 (rank : 1177)
Query Neighborhood Hits	1931	Target Neighborhood Hits	12	Shared Neighborhood Hits	7
SwissProt Accessions	P60761, Q3TYH4	Gene names	Nrgn
Domain Architecture	No domain graphic available
Description	Neurogranin (Ng) (RC3).

LAD1_MOUSE
NC score	0.039768 (rank : 1397)	θ value	6.88961 (rank : 1787)
Query Neighborhood Hits	1931	Target Neighborhood Hits	391	Shared Neighborhood Hits	111
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

TIMD1_HUMAN
NC score	0.039742 (rank : 1398)	θ value	0.0330416 (rank : 1107)
Query Neighborhood Hits	1931	Target Neighborhood Hits	155	Shared Neighborhood Hits	60
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

RP1L1_HUMAN
NC score	0.039701 (rank : 1399)	θ value	0.62314 (rank : 1350)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1072	Shared Neighborhood Hits	238
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

IASPP_HUMAN
NC score	0.039692 (rank : 1400)	θ value	0.47712 (rank : 1304)
Query Neighborhood Hits	1931	Target Neighborhood Hits	688	Shared Neighborhood Hits	187
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PRG4_HUMAN
NC score	0.039408 (rank : 1401)	θ value	0.125558 (rank : 1194)
Query Neighborhood Hits	1931	Target Neighborhood Hits	764	Shared Neighborhood Hits	186
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

GRIN1_HUMAN
NC score	0.039325 (rank : 1402)	θ value	8.99809 (rank : 1859)
Query Neighborhood Hits	1931	Target Neighborhood Hits	681	Shared Neighborhood Hits	210
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

SLAF5_MOUSE
NC score	0.039289 (rank : 1403)	θ value	1.06291 (rank : 1425)
Query Neighborhood Hits	1931	Target Neighborhood Hits	93	Shared Neighborhood Hits	57
SwissProt Accessions	Q18PI6, Q18PI7, Q3TBT1, Q3U0A2, Q8BFV0, Q9Z178	Gene names	Cd84, Slamf5
Domain Architecture	No domain graphic available
Description	SLAM family member 5 precursor (Signaling lymphocytic activation molecule 5) (Leukocyte differentiation antigen CD84) (CD84 antigen).

PRR12_HUMAN
NC score	0.039225 (rank : 1404)	θ value	0.813845 (rank : 1387)
Query Neighborhood Hits	1931	Target Neighborhood Hits	460	Shared Neighborhood Hits	136
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

ATN1_HUMAN
NC score	0.038846 (rank : 1405)	θ value	0.0961366 (rank : 1166)
Query Neighborhood Hits	1931	Target Neighborhood Hits	676	Shared Neighborhood Hits	173
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

DGKK_HUMAN
NC score	0.038456 (rank : 1406)	θ value	1.81305 (rank : 1490)
Query Neighborhood Hits	1931	Target Neighborhood Hits	378	Shared Neighborhood Hits	126
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

WBP11_HUMAN
NC score	0.038216 (rank : 1407)	θ value	0.0330416 (rank : 1109)
Query Neighborhood Hits	1931	Target Neighborhood Hits	354	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

MUC7_HUMAN
NC score	0.038166 (rank : 1408)	θ value	8.99809 (rank : 1882)
Query Neighborhood Hits	1931	Target Neighborhood Hits	538	Shared Neighborhood Hits	158
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

SHAN1_HUMAN
NC score	0.038165 (rank : 1409)	θ value	1.81305 (rank : 1511)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1041	Shared Neighborhood Hits	252
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ENAH_MOUSE
NC score	0.038139 (rank : 1410)	θ value	0.365318 (rank : 1271)
Query Neighborhood Hits	1931	Target Neighborhood Hits	919	Shared Neighborhood Hits	208
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

CN155_HUMAN
NC score	0.038045 (rank : 1411)	θ value	1.06291 (rank : 1401)
Query Neighborhood Hits	1931	Target Neighborhood Hits	385	Shared Neighborhood Hits	104
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

MLL2_HUMAN
NC score	0.037763 (rank : 1412)	θ value	0.0431538 (rank : 1122)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1788	Shared Neighborhood Hits	375
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

PRB3_HUMAN
NC score	0.037705 (rank : 1413)	θ value	1.81305 (rank : 1506)
Query Neighborhood Hits	1931	Target Neighborhood Hits	318	Shared Neighborhood Hits	117
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

SAPS1_HUMAN
NC score	0.037679 (rank : 1414)	θ value	0.125558 (rank : 1195)
Query Neighborhood Hits	1931	Target Neighborhood Hits	704	Shared Neighborhood Hits	256
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

GPS2_HUMAN
NC score	0.037664 (rank : 1415)	θ value	0.47712 (rank : 1303)
Query Neighborhood Hits	1931	Target Neighborhood Hits	459	Shared Neighborhood Hits	116
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

WASL_HUMAN
NC score	0.037657 (rank : 1416)	θ value	6.88961 (rank : 1814)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	125
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

CD2_HUMAN
NC score	0.037432 (rank : 1417)	θ value	0.47712 (rank : 1299)
Query Neighborhood Hits	1931	Target Neighborhood Hits	504	Shared Neighborhood Hits	177
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

TRML1_MOUSE
NC score	0.037262 (rank : 1418)	θ value	1.06291 (rank : 1429)
Query Neighborhood Hits	1931	Target Neighborhood Hits	44	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K558, Q9D3N6	Gene names	Treml1, Tlt1
Domain Architecture	No domain graphic available
Description	Trem-like transcript 1 protein precursor (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1).

WBP11_MOUSE
NC score	0.037100 (rank : 1419)	θ value	0.0330416 (rank : 1110)
Query Neighborhood Hits	1931	Target Neighborhood Hits	362	Shared Neighborhood Hits	116
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

MUC_MOUSE
NC score	0.036926 (rank : 1420)	θ value	0.00665767 (rank : 1040)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	74
SwissProt Accessions	P01872	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region secreted form.

SFPQ_MOUSE
NC score	0.036920 (rank : 1421)	θ value	0.00134147 (rank : 992)
Query Neighborhood Hits	1931	Target Neighborhood Hits	958	Shared Neighborhood Hits	194
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

PSL1_HUMAN
NC score	0.036715 (rank : 1422)	θ value	0.365318 (rank : 1291)
Query Neighborhood Hits	1931	Target Neighborhood Hits	650	Shared Neighborhood Hits	243
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

BCL9_HUMAN
NC score	0.036678 (rank : 1423)	θ value	3.0926 (rank : 1579)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1008	Shared Neighborhood Hits	309
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

BASP_HUMAN
NC score	0.036677 (rank : 1424)	θ value	5.27518 (rank : 1702)
Query Neighborhood Hits	1931	Target Neighborhood Hits	321	Shared Neighborhood Hits	78
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

MUCM_MOUSE
NC score	0.036635 (rank : 1425)	θ value	0.00665767 (rank : 1039)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	73
SwissProt Accessions	P01873	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu chain C region membrane-bound form.

K0310_HUMAN
NC score	0.036446 (rank : 1426)	θ value	0.0330416 (rank : 1099)
Query Neighborhood Hits	1931	Target Neighborhood Hits	420	Shared Neighborhood Hits	141
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

CSKI1_HUMAN
NC score	0.036311 (rank : 1427)	θ value	0.365318 (rank : 1270)
Query Neighborhood Hits	1931	Target Neighborhood Hits	997	Shared Neighborhood Hits	289
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

SC24C_HUMAN
NC score	0.036239 (rank : 1428)	θ value	0.163984 (rank : 1220)
Query Neighborhood Hits	1931	Target Neighborhood Hits	662	Shared Neighborhood Hits	239
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

CD7_HUMAN
NC score	0.036048 (rank : 1429)	θ value	0.0330416 (rank : 1092)
Query Neighborhood Hits	1931	Target Neighborhood Hits	190	Shared Neighborhood Hits	56
SwissProt Accessions	P09564	Gene names	CD7
Domain Architecture
Description	T-cell antigen CD7 precursor (GP40) (T-cell leukemia antigen) (TP41) (Leu-9).

SCN4B_HUMAN
NC score	0.035910 (rank : 1430)	θ value	8.99809 (rank : 1902)
Query Neighborhood Hits	1931	Target Neighborhood Hits	68	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWT1, Q6PIG5	Gene names	SCN4B
Domain Architecture	No domain graphic available
Description	Sodium channel beta-4 subunit precursor.

LAD1_HUMAN
NC score	0.035866 (rank : 1431)	θ value	5.27518 (rank : 1722)
Query Neighborhood Hits	1931	Target Neighborhood Hits	441	Shared Neighborhood Hits	105
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

CNTFR_HUMAN
NC score	0.035602 (rank : 1432)	θ value	0.365318 (rank : 1269)
Query Neighborhood Hits	1931	Target Neighborhood Hits	66	Shared Neighborhood Hits	38
SwissProt Accessions	P26992	Gene names	CNTFR
Domain Architecture
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

ALEX_HUMAN
NC score	0.035330 (rank : 1433)	θ value	1.06291 (rank : 1396)
Query Neighborhood Hits	1931	Target Neighborhood Hits	361	Shared Neighborhood Hits	125
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

TB182_HUMAN
NC score	0.035194 (rank : 1434)	θ value	0.0563607 (rank : 1143)
Query Neighborhood Hits	1931	Target Neighborhood Hits	414	Shared Neighborhood Hits	116
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

IL12B_HUMAN
NC score	0.035134 (rank : 1435)	θ value	0.365318 (rank : 1279)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	34
SwissProt Accessions	P29460	Gene names	IL12B, NKSF2
Domain Architecture
Description	Interleukin-12 beta chain precursor (IL-12B) (IL-12 p40) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (NK cell stimulatory factor chain 2) (NKSF2).

SYN1_MOUSE
NC score	0.034966 (rank : 1436)	θ value	0.0431538 (rank : 1125)
Query Neighborhood Hits	1931	Target Neighborhood Hits	363	Shared Neighborhood Hits	141
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

JPH2_HUMAN
NC score	0.034755 (rank : 1437)	θ value	0.125558 (rank : 1189)
Query Neighborhood Hits	1931	Target Neighborhood Hits	639	Shared Neighborhood Hits	237
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

K1683_HUMAN
NC score	0.034591 (rank : 1438)	θ value	0.21417 (rank : 1231)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

ENAH_HUMAN
NC score	0.034533 (rank : 1439)	θ value	4.03905 (rank : 1648)
Query Neighborhood Hits	1931	Target Neighborhood Hits	784	Shared Neighborhood Hits	153
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

TENS1_HUMAN
NC score	0.034426 (rank : 1440)	θ value	0.47712 (rank : 1319)
Query Neighborhood Hits	1931	Target Neighborhood Hits	400	Shared Neighborhood Hits	131
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

CIC_HUMAN
NC score	0.034386 (rank : 1441)	θ value	0.813845 (rank : 1367)
Query Neighborhood Hits	1931	Target Neighborhood Hits	992	Shared Neighborhood Hits	296
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

SEM4D_HUMAN
NC score	0.034368 (rank : 1442)	θ value	0.0961366 (rank : 1178)
Query Neighborhood Hits	1931	Target Neighborhood Hits	139	Shared Neighborhood Hits	86
SwissProt Accessions	Q92854, Q7Z5S4	Gene names	SEMA4D, CD100
Domain Architecture
Description	Semaphorin-4D precursor (Leukocyte activation antigen CD100) (BB18) (A8) (GR3).

CO039_MOUSE
NC score	0.034204 (rank : 1443)	θ value	4.03905 (rank : 1637)
Query Neighborhood Hits	1931	Target Neighborhood Hits	445	Shared Neighborhood Hits	171
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

PRG4_MOUSE
NC score	0.033847 (rank : 1444)	θ value	8.99809 (rank : 1896)
Query Neighborhood Hits	1931	Target Neighborhood Hits	624	Shared Neighborhood Hits	154
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

CD79B_HUMAN
NC score	0.033756 (rank : 1445)	θ value	0.62314 (rank : 1328)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	66
SwissProt Accessions	P40259, Q9BU06	Gene names	CD79B, B29, IGB
Domain Architecture
Description	B-cell antigen receptor complex-associated protein beta-chain precursor (B-cell-specific glycoprotein B29) (Immunoglobulin- associated B29 protein) (IG-beta) (CD79b antigen).

MAP1A_HUMAN
NC score	0.033733 (rank : 1446)	θ value	4.03905 (rank : 1667)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1626	Shared Neighborhood Hits	300
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

CNTFR_MOUSE
NC score	0.033716 (rank : 1447)	θ value	4.03905 (rank : 1635)
Query Neighborhood Hits	1931	Target Neighborhood Hits	74	Shared Neighborhood Hits	47
SwissProt Accessions	O88507, Q80T01	Gene names	Cntfr
Domain Architecture	No domain graphic available
Description	Ciliary neurotrophic factor receptor alpha precursor (CNTFR alpha).

SYN1_HUMAN
NC score	0.033410 (rank : 1448)	θ value	0.0736092 (rank : 1160)
Query Neighborhood Hits	1931	Target Neighborhood Hits	419	Shared Neighborhood Hits	151
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

G7C_HUMAN
NC score	0.033124 (rank : 1449)	θ value	0.21417 (rank : 1228)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y334, Q5SSR5, Q96QC8, Q9UMP9	Gene names	C6orf27, G7C, NG37
Domain Architecture	No domain graphic available
Description	Protein G7c precursor.

IZUM1_HUMAN
NC score	0.033106 (rank : 1450)	θ value	0.0563607 (rank : 1133)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	17
SwissProt Accessions	Q8IYV9, Q6Q8P6, Q6Q8P7	Gene names	IZUMO1
Domain Architecture	No domain graphic available
Description	Izumo sperm-egg fusion protein 1 precursor (Sperm-specific protein izumo).

SYNJ1_MOUSE
NC score	0.033102 (rank : 1451)	θ value	0.0330416 (rank : 1106)
Query Neighborhood Hits	1931	Target Neighborhood Hits	516	Shared Neighborhood Hits	174
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

RP1L1_MOUSE
NC score	0.033098 (rank : 1452)	θ value	4.03905 (rank : 1678)
Query Neighborhood Hits	1931	Target Neighborhood Hits	170	Shared Neighborhood Hits	53
SwissProt Accessions	Q8CGM2, Q8K0I4	Gene names	Rp1l1, Rp1hl1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein (Retinitis pigmentosa 1-like protein 1).

WASP_MOUSE
NC score	0.033022 (rank : 1453)	θ value	0.0252991 (rank : 1090)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	98
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

DIDO1_HUMAN
NC score	0.032890 (rank : 1454)	θ value	8.99809 (rank : 1843)
Query Neighborhood Hits	1931	Target Neighborhood Hits	960	Shared Neighborhood Hits	269
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

LEPR_HUMAN
NC score	0.032871 (rank : 1455)	θ value	0.813845 (rank : 1379)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	61
SwissProt Accessions	P48357, Q13592, Q13593, Q13594, Q92919, Q92920, Q92921	Gene names	LEPR, DB, OBR
Domain Architecture
Description	Leptin receptor precursor (LEP-R) (OB receptor) (OB-R) (HuB219) (CD295 antigen).

APXL_HUMAN
NC score	0.032755 (rank : 1456)	θ value	0.365318 (rank : 1267)
Query Neighborhood Hits	1931	Target Neighborhood Hits	553	Shared Neighborhood Hits	131
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

WIRE_HUMAN
NC score	0.032702 (rank : 1457)	θ value	1.06291 (rank : 1431)
Query Neighborhood Hits	1931	Target Neighborhood Hits	329	Shared Neighborhood Hits	110
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

TCOF_MOUSE
NC score	0.032265 (rank : 1458)	θ value	1.06291 (rank : 1427)
Query Neighborhood Hits	1931	Target Neighborhood Hits	471	Shared Neighborhood Hits	108
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

SSBP4_HUMAN
NC score	0.032148 (rank : 1459)	θ value	0.00390308 (rank : 1026)
Query Neighborhood Hits	1931	Target Neighborhood Hits	753	Shared Neighborhood Hits	254
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

YLPM1_HUMAN
NC score	0.031990 (rank : 1460)	θ value	1.81305 (rank : 1518)
Query Neighborhood Hits	1931	Target Neighborhood Hits	670	Shared Neighborhood Hits	171
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ARI1B_HUMAN
NC score	0.031715 (rank : 1461)	θ value	0.365318 (rank : 1268)
Query Neighborhood Hits	1931	Target Neighborhood Hits	567	Shared Neighborhood Hits	185
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

MLL3_HUMAN
NC score	0.031555 (rank : 1462)	θ value	1.81305 (rank : 1502)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1644	Shared Neighborhood Hits	363
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

RERE_HUMAN
NC score	0.031194 (rank : 1463)	θ value	0.62314 (rank : 1347)
Query Neighborhood Hits	1931	Target Neighborhood Hits	779	Shared Neighborhood Hits	212
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

ENL_HUMAN
NC score	0.031167 (rank : 1464)	θ value	0.0563607 (rank : 1129)
Query Neighborhood Hits	1931	Target Neighborhood Hits	305	Shared Neighborhood Hits	69
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

PS1C2_MOUSE
NC score	0.031018 (rank : 1465)	θ value	1.81305 (rank : 1507)
Query Neighborhood Hits	1931	Target Neighborhood Hits	59	Shared Neighborhood Hits	28
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

CSKI2_HUMAN
NC score	0.030912 (rank : 1466)	θ value	0.163984 (rank : 1206)
Query Neighborhood Hits	1931	Target Neighborhood Hits	747	Shared Neighborhood Hits	194
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

K1802_MOUSE
NC score	0.030889 (rank : 1467)	θ value	0.0252991 (rank : 1083)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1596	Shared Neighborhood Hits	356
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SF01_HUMAN
NC score	0.030849 (rank : 1468)	θ value	1.38821 (rank : 1464)
Query Neighborhood Hits	1931	Target Neighborhood Hits	287	Shared Neighborhood Hits	106
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

PELP1_MOUSE
NC score	0.030844 (rank : 1469)	θ value	3.0926 (rank : 1610)
Query Neighborhood Hits	1931	Target Neighborhood Hits	709	Shared Neighborhood Hits	202
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PRPC_HUMAN
NC score	0.030756 (rank : 1470)	θ value	0.365318 (rank : 1289)
Query Neighborhood Hits	1931	Target Neighborhood Hits	165	Shared Neighborhood Hits	60
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

SF3B2_HUMAN
NC score	0.030754 (rank : 1471)	θ value	0.47712 (rank : 1315)
Query Neighborhood Hits	1931	Target Neighborhood Hits	157	Shared Neighborhood Hits	47
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

SYNPO_HUMAN
NC score	0.030705 (rank : 1472)	θ value	0.00665767 (rank : 1046)
Query Neighborhood Hits	1931	Target Neighborhood Hits	281	Shared Neighborhood Hits	100
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

BCL9_MOUSE
NC score	0.030622 (rank : 1473)	θ value	5.27518 (rank : 1703)
Query Neighborhood Hits	1931	Target Neighborhood Hits	770	Shared Neighborhood Hits	267
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

SPT5H_HUMAN
NC score	0.030545 (rank : 1474)	θ value	0.0736092 (rank : 1157)
Query Neighborhood Hits	1931	Target Neighborhood Hits	436	Shared Neighborhood Hits	159
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SNPC4_HUMAN
NC score	0.030208 (rank : 1475)	θ value	8.99809 (rank : 1907)
Query Neighborhood Hits	1931	Target Neighborhood Hits	589	Shared Neighborhood Hits	205
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SPT5H_MOUSE
NC score	0.030141 (rank : 1476)	θ value	0.0736092 (rank : 1158)
Query Neighborhood Hits	1931	Target Neighborhood Hits	437	Shared Neighborhood Hits	158
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

CJ078_MOUSE
NC score	0.030119 (rank : 1477)	θ value	0.21417 (rank : 1227)
Query Neighborhood Hits	1931	Target Neighborhood Hits	559	Shared Neighborhood Hits	127
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

DOT1L_HUMAN
NC score	0.030057 (rank : 1478)	θ value	8.99809 (rank : 1844)
Query Neighborhood Hits	1931	Target Neighborhood Hits	660	Shared Neighborhood Hits	177
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

MYO9B_HUMAN
NC score	0.029952 (rank : 1479)	θ value	6.88961 (rank : 1790)
Query Neighborhood Hits	1931	Target Neighborhood Hits	641	Shared Neighborhood Hits	187
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

SEM3C_MOUSE
NC score	0.029938 (rank : 1480)	θ value	0.47712 (rank : 1313)
Query Neighborhood Hits	1931	Target Neighborhood Hits	113	Shared Neighborhood Hits	70
SwissProt Accessions	Q62181	Gene names	Sema3c, Semae, SemE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

BT3A3_HUMAN
NC score	0.029876 (rank : 1481)	θ value	8.99809 (rank : 1830)
Query Neighborhood Hits	1931	Target Neighborhood Hits	233	Shared Neighborhood Hits	115
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

CJ012_HUMAN
NC score	0.029843 (rank : 1482)	θ value	3.0926 (rank : 1580)
Query Neighborhood Hits	1931	Target Neighborhood Hits	467	Shared Neighborhood Hits	111
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CNTRB_MOUSE
NC score	0.029488 (rank : 1483)	θ value	8.99809 (rank : 1837)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1029	Shared Neighborhood Hits	159
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

NCOR2_MOUSE
NC score	0.029383 (rank : 1484)	θ value	1.81305 (rank : 1503)
Query Neighborhood Hits	1931	Target Neighborhood Hits	790	Shared Neighborhood Hits	175
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

BT3A1_HUMAN
NC score	0.029233 (rank : 1485)	θ value	6.88961 (rank : 1755)
Query Neighborhood Hits	1931	Target Neighborhood Hits	229	Shared Neighborhood Hits	110
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

CSKI2_MOUSE
NC score	0.029167 (rank : 1486)	θ value	3.0926 (rank : 1586)
Query Neighborhood Hits	1931	Target Neighborhood Hits	812	Shared Neighborhood Hits	222
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

WIRE_MOUSE
NC score	0.029119 (rank : 1487)	θ value	1.38821 (rank : 1475)
Query Neighborhood Hits	1931	Target Neighborhood Hits	310	Shared Neighborhood Hits	111
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

WASP_HUMAN
NC score	0.029039 (rank : 1488)	θ value	0.279714 (rank : 1262)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	87
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

CEL_HUMAN
NC score	0.028954 (rank : 1489)	θ value	0.0961366 (rank : 1169)
Query Neighborhood Hits	1931	Target Neighborhood Hits	896	Shared Neighborhood Hits	271
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

GGN_MOUSE
NC score	0.028613 (rank : 1490)	θ value	5.27518 (rank : 1712)
Query Neighborhood Hits	1931	Target Neighborhood Hits	311	Shared Neighborhood Hits	107
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

RERE_MOUSE
NC score	0.028543 (rank : 1491)	θ value	1.38821 (rank : 1463)
Query Neighborhood Hits	1931	Target Neighborhood Hits	785	Shared Neighborhood Hits	204
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

SH2D3_MOUSE
NC score	0.028493 (rank : 1492)	θ value	8.99809 (rank : 1906)
Query Neighborhood Hits	1931	Target Neighborhood Hits	174	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

ANK2_HUMAN
NC score	0.028419 (rank : 1493)	θ value	5.27518 (rank : 1697)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1615	Shared Neighborhood Hits	333
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

EPN3_MOUSE
NC score	0.028409 (rank : 1494)	θ value	0.00134147 (rank : 987)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	130
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

CD19_HUMAN
NC score	0.028170 (rank : 1495)	θ value	0.0431538 (rank : 1114)
Query Neighborhood Hits	1931	Target Neighborhood Hits	63	Shared Neighborhood Hits	26
SwissProt Accessions	P15391, Q96S68, Q9BRD6	Gene names	CD19
Domain Architecture
Description	B-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B- lymphocyte surface antigen B4) (Leu-12).

CN032_HUMAN
NC score	0.028132 (rank : 1496)	θ value	0.62314 (rank : 1329)
Query Neighborhood Hits	1931	Target Neighborhood Hits	267	Shared Neighborhood Hits	94
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

MLL3_MOUSE
NC score	0.027981 (rank : 1497)	θ value	0.813845 (rank : 1382)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1399	Shared Neighborhood Hits	306
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

CO002_HUMAN
NC score	0.027947 (rank : 1498)	θ value	0.813845 (rank : 1368)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	122
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

SEM4D_MOUSE
NC score	0.027860 (rank : 1499)	θ value	0.279714 (rank : 1258)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	69
SwissProt Accessions	O09126	Gene names	Sema4d, Semacl2, Semaj
Domain Architecture
Description	Semaphorin-4D precursor (Semaphorin J) (Sema J) (Semaphorin C-like 2) (M-Sema G).

SEM3C_HUMAN
NC score	0.027669 (rank : 1500)	θ value	0.62314 (rank : 1351)
Query Neighborhood Hits	1931	Target Neighborhood Hits	106	Shared Neighborhood Hits	66
SwissProt Accessions	Q99985	Gene names	SEMA3C, SEMAE
Domain Architecture
Description	Semaphorin-3C precursor (Semaphorin E) (Sema E).

PKHA6_HUMAN
NC score	0.027443 (rank : 1501)	θ value	0.47712 (rank : 1311)
Query Neighborhood Hits	1931	Target Neighborhood Hits	556	Shared Neighborhood Hits	152
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SEM4C_HUMAN
NC score	0.027393 (rank : 1502)	θ value	0.0148317 (rank : 1065)
Query Neighborhood Hits	1931	Target Neighborhood Hits	84	Shared Neighborhood Hits	38
SwissProt Accessions	Q9C0C4, Q7Z5X0	Gene names	SEMA4C, KIAA1739
Domain Architecture
Description	Semaphorin-4C precursor.

SF01_MOUSE
NC score	0.027116 (rank : 1503)	θ value	1.06291 (rank : 1424)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	87
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

ARI1A_HUMAN
NC score	0.027054 (rank : 1504)	θ value	6.88961 (rank : 1752)
Query Neighborhood Hits	1931	Target Neighborhood Hits	787	Shared Neighborhood Hits	243
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

SLAF6_HUMAN
NC score	0.026856 (rank : 1505)	θ value	1.38821 (rank : 1468)
Query Neighborhood Hits	1931	Target Neighborhood Hits	62	Shared Neighborhood Hits	43
SwissProt Accessions	Q96DU3, Q5TAT3, Q96DV0	Gene names	SLAMF6, KALI
Domain Architecture	No domain graphic available
Description	SLAM family member 6 precursor (NK-T-B-antigen) (NTB-A) (Activating NK receptor).

HPLN2_MOUSE
NC score	0.026826 (rank : 1506)	θ value	0.813845 (rank : 1376)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ESM3	Gene names	Hapln2, Bral1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

SEM3F_HUMAN
NC score	0.026560 (rank : 1507)	θ value	0.0330416 (rank : 1103)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	61
SwissProt Accessions	Q13275, Q13274, Q13372, Q15704	Gene names	SEMA3F
Domain Architecture
Description	Semaphorin-3F precursor (Semaphorin IV) (Sema IV) (Sema III/F).

TRIM9_HUMAN
NC score	0.026259 (rank : 1508)	θ value	0.279714 (rank : 1261)
Query Neighborhood Hits	1931	Target Neighborhood Hits	294	Shared Neighborhood Hits	63
SwissProt Accessions	Q9C026, Q92557, Q96D24, Q96NI4, Q9C025, Q9C027	Gene names	TRIM9, KIAA0282, RNF91
Domain Architecture
Description	Tripartite motif-containing protein 9 (RING finger protein 91).

CO039_HUMAN
NC score	0.025983 (rank : 1509)	θ value	4.03905 (rank : 1636)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

MKL1_MOUSE
NC score	0.025948 (rank : 1510)	θ value	0.365318 (rank : 1284)
Query Neighborhood Hits	1931	Target Neighborhood Hits	667	Shared Neighborhood Hits	218
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

SYNPO_MOUSE
NC score	0.025615 (rank : 1511)	θ value	0.62314 (rank : 1355)
Query Neighborhood Hits	1931	Target Neighborhood Hits	242	Shared Neighborhood Hits	85
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

DREB_MOUSE
NC score	0.025214 (rank : 1512)	θ value	1.06291 (rank : 1403)
Query Neighborhood Hits	1931	Target Neighborhood Hits	446	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

TRIM9_MOUSE
NC score	0.025182 (rank : 1513)	θ value	0.0736092 (rank : 1161)
Query Neighborhood Hits	1931	Target Neighborhood Hits	274	Shared Neighborhood Hits	53
SwissProt Accessions	Q8C7M3, Q6ZQE5, Q80WT6, Q8C7Z4, Q8CC32, Q8CEG2, Q99PQ3	Gene names	Trim9, Kiaa0282
Domain Architecture
Description	Tripartite motif-containing protein 9.

SASH1_MOUSE
NC score	0.025097 (rank : 1514)	θ value	8.99809 (rank : 1901)
Query Neighborhood Hits	1931	Target Neighborhood Hits	263	Shared Neighborhood Hits	91
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

CBP_HUMAN
NC score	0.025060 (rank : 1515)	θ value	8.99809 (rank : 1833)
Query Neighborhood Hits	1931	Target Neighborhood Hits	941	Shared Neighborhood Hits	256
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

TCGAP_HUMAN
NC score	0.025035 (rank : 1516)	θ value	0.279714 (rank : 1259)
Query Neighborhood Hits	1931	Target Neighborhood Hits	872	Shared Neighborhood Hits	262
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

EP300_HUMAN
NC score	0.024672 (rank : 1517)	θ value	6.88961 (rank : 1770)
Query Neighborhood Hits	1931	Target Neighborhood Hits	821	Shared Neighborhood Hits	236
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

MINT_HUMAN
NC score	0.024589 (rank : 1518)	θ value	1.06291 (rank : 1413)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1291	Shared Neighborhood Hits	248
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CSF1_HUMAN
NC score	0.024520 (rank : 1519)	θ value	1.38821 (rank : 1443)
Query Neighborhood Hits	1931	Target Neighborhood Hits	258	Shared Neighborhood Hits	115
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

PTN23_MOUSE
NC score	0.024502 (rank : 1520)	θ value	2.36792 (rank : 1563)
Query Neighborhood Hits	1931	Target Neighborhood Hits	726	Shared Neighborhood Hits	170
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

LPP_HUMAN
NC score	0.024222 (rank : 1521)	θ value	3.0926 (rank : 1603)
Query Neighborhood Hits	1931	Target Neighborhood Hits	775	Shared Neighborhood Hits	234
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

TM108_HUMAN
NC score	0.024111 (rank : 1522)	θ value	1.81305 (rank : 1515)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3	Gene names	TMEM108, KIAA1690
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

MYO9B_MOUSE
NC score	0.024080 (rank : 1523)	θ value	2.36792 (rank : 1557)
Query Neighborhood Hits	1931	Target Neighborhood Hits	311	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

SYNJ1_HUMAN
NC score	0.024001 (rank : 1524)	θ value	0.0961366 (rank : 1180)
Query Neighborhood Hits	1931	Target Neighborhood Hits	498	Shared Neighborhood Hits	162
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

CRSP7_HUMAN
NC score	0.023973 (rank : 1525)	θ value	0.62314 (rank : 1331)
Query Neighborhood Hits	1931	Target Neighborhood Hits	247	Shared Neighborhood Hits	91
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

CIC_MOUSE
NC score	0.023502 (rank : 1526)	θ value	1.38821 (rank : 1440)
Query Neighborhood Hits	1931	Target Neighborhood Hits	742	Shared Neighborhood Hits	223
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

PTN23_HUMAN
NC score	0.023436 (rank : 1527)	θ value	4.03905 (rank : 1676)
Query Neighborhood Hits	1931	Target Neighborhood Hits	646	Shared Neighborhood Hits	157
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

MAML3_HUMAN
NC score	0.023175 (rank : 1528)	θ value	0.62314 (rank : 1341)
Query Neighborhood Hits	1931	Target Neighborhood Hits	323	Shared Neighborhood Hits	117
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

SEM3F_MOUSE
NC score	0.023103 (rank : 1529)	θ value	0.0563607 (rank : 1141)
Query Neighborhood Hits	1931	Target Neighborhood Hits	86	Shared Neighborhood Hits	46
SwissProt Accessions	O88632, O88633	Gene names	Sema3f
Domain Architecture
Description	Semaphorin-3F precursor (Semaphorin IV) (Sema IV).

TRML1_HUMAN
NC score	0.023041 (rank : 1530)	θ value	0.47712 (rank : 1321)
Query Neighborhood Hits	1931	Target Neighborhood Hits	33	Shared Neighborhood Hits	18
SwissProt Accessions	Q86YW5, Q496B3, Q8IWY1, Q8IWY2	Gene names	TREML1, TLT1
Domain Architecture	No domain graphic available
Description	Trem-like transcript 1 protein precursor (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1).

PHLPP_HUMAN
NC score	0.022692 (rank : 1531)	θ value	4.03905 (rank : 1674)
Query Neighborhood Hits	1931	Target Neighborhood Hits	604	Shared Neighborhood Hits	161
SwissProt Accessions	O60346, Q641Q7, Q6P4C4, Q6PJI6, Q86TN6, Q96FK2, Q9NUY1	Gene names	PHLPP, KIAA0606, PLEKHE1, SCOP
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP).

MUCDL_HUMAN
NC score	0.022420 (rank : 1532)	θ value	0.47712 (rank : 1307)
Query Neighborhood Hits	1931	Target Neighborhood Hits	777	Shared Neighborhood Hits	230
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SYN3_MOUSE
NC score	0.022355 (rank : 1533)	θ value	0.47712 (rank : 1317)
Query Neighborhood Hits	1931	Target Neighborhood Hits	200	Shared Neighborhood Hits	76
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

SEM4G_HUMAN
NC score	0.022346 (rank : 1534)	θ value	4.03905 (rank : 1681)
Query Neighborhood Hits	1931	Target Neighborhood Hits	88	Shared Neighborhood Hits	45
SwissProt Accessions	Q9NTN9, Q9HCF3	Gene names	SEMA4G, KIAA1619
Domain Architecture
Description	Semaphorin-4G precursor.

SMOO_HUMAN
NC score	0.022165 (rank : 1535)	θ value	0.0563607 (rank : 1142)
Query Neighborhood Hits	1931	Target Neighborhood Hits	391	Shared Neighborhood Hits	120
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

BAT3_HUMAN
NC score	0.022162 (rank : 1536)	θ value	1.81305 (rank : 1482)
Query Neighborhood Hits	1931	Target Neighborhood Hits	490	Shared Neighborhood Hits	180
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

SYN3_HUMAN
NC score	0.022161 (rank : 1537)	θ value	1.81305 (rank : 1514)
Query Neighborhood Hits	1931	Target Neighborhood Hits	203	Shared Neighborhood Hits	74
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

SEM4C_MOUSE
NC score	0.021941 (rank : 1538)	θ value	0.21417 (rank : 1238)
Query Neighborhood Hits	1931	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	Q64151	Gene names	Sema4c, Semacl1, Semai
Domain Architecture
Description	Semaphorin-4C precursor (Semaphorin I) (Sema I) (Semaphorin C-like 1) (M-Sema F).

SF3A2_MOUSE
NC score	0.021820 (rank : 1539)	θ value	1.38821 (rank : 1465)
Query Neighborhood Hits	1931	Target Neighborhood Hits	247	Shared Neighborhood Hits	96
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

RTN4_HUMAN
NC score	0.021511 (rank : 1540)	θ value	0.163984 (rank : 1219)
Query Neighborhood Hits	1931	Target Neighborhood Hits	357	Shared Neighborhood Hits	90
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SEM3A_MOUSE
NC score	0.021245 (rank : 1541)	θ value	0.0252991 (rank : 1085)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	48
SwissProt Accessions	O08665, Q5BL08, Q62180, Q62215	Gene names	Sema3a, Semad, SemD
Domain Architecture
Description	Semaphorin-3A precursor (Semaphorin III) (Sema III) (Semaphorin D) (Sema D).

ACD_HUMAN
NC score	0.021207 (rank : 1542)	θ value	0.813845 (rank : 1360)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	50
SwissProt Accessions	Q96AP0, Q562H5, Q9H8F9	Gene names	ACD, PIP1, PTOP
Domain Architecture	No domain graphic available
Description	Adrenocortical dysplasia protein homolog (POT1 and TIN2-interacting protein).

SEM3D_MOUSE
NC score	0.020986 (rank : 1543)	θ value	0.125558 (rank : 1196)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BH34	Gene names	Sema3d
Domain Architecture	No domain graphic available
Description	Semaphorin-3D precursor.

BAT3_MOUSE
NC score	0.020912 (rank : 1544)	θ value	6.88961 (rank : 1754)
Query Neighborhood Hits	1931	Target Neighborhood Hits	518	Shared Neighborhood Hits	187
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

SEM3D_HUMAN
NC score	0.020616 (rank : 1545)	θ value	0.0563607 (rank : 1140)
Query Neighborhood Hits	1931	Target Neighborhood Hits	104	Shared Neighborhood Hits	46
SwissProt Accessions	O95025, Q6UW77, Q8NCQ1	Gene names	SEMA3D
Domain Architecture
Description	Semaphorin-3D precursor.

AFF1_MOUSE
NC score	0.020492 (rank : 1546)	θ value	0.813845 (rank : 1362)
Query Neighborhood Hits	1931	Target Neighborhood Hits	351	Shared Neighborhood Hits	81
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CS007_MOUSE
NC score	0.020457 (rank : 1547)	θ value	0.47712 (rank : 1302)
Query Neighborhood Hits	1931	Target Neighborhood Hits	464	Shared Neighborhood Hits	136
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

HPLN4_HUMAN
NC score	0.020419 (rank : 1548)	θ value	8.99809 (rank : 1862)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	68
SwissProt Accessions	Q86UW8, Q96PW2	Gene names	HAPLN4, BRAL2, KIAA1926
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2).

PTPRN_HUMAN
NC score	0.020398 (rank : 1549)	θ value	0.62314 (rank : 1345)
Query Neighborhood Hits	1931	Target Neighborhood Hits	156	Shared Neighborhood Hits	49
SwissProt Accessions	Q16849, Q08319	Gene names	PTPRN, ICA3, ICA512
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3).

FXL19_MOUSE
NC score	0.020389 (rank : 1550)	θ value	0.00390308 (rank : 1018)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	67
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

TREM2_HUMAN
NC score	0.020322 (rank : 1551)	θ value	6.88961 (rank : 1807)
Query Neighborhood Hits	1931	Target Neighborhood Hits	60	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NZC2, Q8N5H8, Q8WYN6	Gene names	TREM2
Domain Architecture	No domain graphic available
Description	Triggering receptor expressed on myeloid cells 2 precursor (Triggering receptor expressed on monocytes 2) (TREM-2).

PELP1_HUMAN
NC score	0.020298 (rank : 1552)	θ value	1.38821 (rank : 1461)
Query Neighborhood Hits	1931	Target Neighborhood Hits	596	Shared Neighborhood Hits	113
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

IRS2_HUMAN
NC score	0.020267 (rank : 1553)	θ value	4.03905 (rank : 1659)
Query Neighborhood Hits	1931	Target Neighborhood Hits	262	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

EPN1_HUMAN
NC score	0.019893 (rank : 1554)	θ value	0.0736092 (rank : 1149)
Query Neighborhood Hits	1931	Target Neighborhood Hits	206	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

SEM3B_HUMAN
NC score	0.019744 (rank : 1555)	θ value	0.0330416 (rank : 1102)
Query Neighborhood Hits	1931	Target Neighborhood Hits	76	Shared Neighborhood Hits	35
SwissProt Accessions	Q13214, Q8TB71, Q8TDV7, Q93018, Q96GX0	Gene names	SEMA3B, SEMA5
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin V) (Sema V) (Sema A(V)).

MUCB_HUMAN
NC score	0.019654 (rank : 1556)	θ value	0.47712 (rank : 1306)
Query Neighborhood Hits	1931	Target Neighborhood Hits	233	Shared Neighborhood Hits	59
SwissProt Accessions	P04220	Gene names
Domain Architecture	No domain graphic available
Description	Ig mu heavy chain disease protein (BOT).

UPK3B_HUMAN
NC score	0.019640 (rank : 1557)	θ value	0.0431538 (rank : 1127)
Query Neighborhood Hits	1931	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BT76, Q86W06	Gene names	UPK3B
Domain Architecture	No domain graphic available
Description	Uroplakin-3B precursor (Uroplakin IIIb) (UPIIIb) (p35).

MUC_HUMAN
NC score	0.019587 (rank : 1558)	θ value	0.47712 (rank : 1308)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	58
SwissProt Accessions	P01871	Gene names	IGHM
Domain Architecture
Description	Ig mu chain C region.

NEST_HUMAN
NC score	0.019544 (rank : 1559)	θ value	3.0926 (rank : 1607)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1305	Shared Neighborhood Hits	192
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

T22D2_HUMAN
NC score	0.019530 (rank : 1560)	θ value	2.36792 (rank : 1569)
Query Neighborhood Hits	1931	Target Neighborhood Hits	250	Shared Neighborhood Hits	91
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

SFR15_HUMAN
NC score	0.019500 (rank : 1561)	θ value	8.99809 (rank : 1905)
Query Neighborhood Hits	1931	Target Neighborhood Hits	368	Shared Neighborhood Hits	97
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

TMAP1_HUMAN
NC score	0.019492 (rank : 1562)	θ value	5.27518 (rank : 1739)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	50
SwissProt Accessions	P84157	Gene names	TMAP1
Domain Architecture	No domain graphic available
Description	Transmembrane anchor protein 1.

FMNL_HUMAN
NC score	0.019486 (rank : 1563)	θ value	1.81305 (rank : 1494)
Query Neighborhood Hits	1931	Target Neighborhood Hits	529	Shared Neighborhood Hits	131
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

CRTC1_HUMAN
NC score	0.019444 (rank : 1564)	θ value	4.03905 (rank : 1639)
Query Neighborhood Hits	1931	Target Neighborhood Hits	319	Shared Neighborhood Hits	121
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

SEM3A_HUMAN
NC score	0.019363 (rank : 1565)	θ value	0.163984 (rank : 1221)
Query Neighborhood Hits	1931	Target Neighborhood Hits	78	Shared Neighborhood Hits	41
SwissProt Accessions	Q14563	Gene names	SEMA3A
Domain Architecture
Description	Semaphorin-3A precursor (Semaphorin III) (Sema III).

MLL4_HUMAN
NC score	0.019360 (rank : 1566)	θ value	0.365318 (rank : 1285)
Query Neighborhood Hits	1931	Target Neighborhood Hits	722	Shared Neighborhood Hits	167
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

NRX2A_HUMAN
NC score	0.019321 (rank : 1567)	θ value	2.36792 (rank : 1561)
Query Neighborhood Hits	1931	Target Neighborhood Hits	614	Shared Neighborhood Hits	186
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

PTPRN_MOUSE
NC score	0.019279 (rank : 1568)	θ value	2.36792 (rank : 1564)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	80
SwissProt Accessions	Q60673, Q62129	Gene names	Ptprn, Ptp35
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase-like N precursor (R-PTP-N) (PTP IA-2).

AGRIN_HUMAN
NC score	0.019257 (rank : 1569)	θ value	5.27518 (rank : 1696)
Query Neighborhood Hits	1931	Target Neighborhood Hits	582	Shared Neighborhood Hits	82
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

NELFA_HUMAN
NC score	0.019238 (rank : 1570)	θ value	1.06291 (rank : 1415)
Query Neighborhood Hits	1931	Target Neighborhood Hits	161	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H3P2, O95392	Gene names	WHSC2, NELFA
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein).

AFF1_HUMAN
NC score	0.019235 (rank : 1571)	θ value	1.81305 (rank : 1479)
Query Neighborhood Hits	1931	Target Neighborhood Hits	506	Shared Neighborhood Hits	115
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

NEUM_MOUSE
NC score	0.019073 (rank : 1572)	θ value	1.38821 (rank : 1459)
Query Neighborhood Hits	1931	Target Neighborhood Hits	149	Shared Neighborhood Hits	37
SwissProt Accessions	P06837	Gene names	Gap43, Basp2
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Calmodulin-binding protein P-57).

TTC15_HUMAN
NC score	0.019014 (rank : 1573)	θ value	0.0961366 (rank : 1181)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WVT3, Q8WVW1, Q9Y395	Gene names	TTC15
Domain Architecture
Description	Tetratricopeptide repeat protein 15 (TPR repeat protein 15).

MY18B_HUMAN
NC score	0.018994 (rank : 1574)	θ value	0.47712 (rank : 1309)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1299	Shared Neighborhood Hits	198
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

SEM3B_MOUSE
NC score	0.018942 (rank : 1575)	θ value	0.163984 (rank : 1222)
Query Neighborhood Hits	1931	Target Neighborhood Hits	75	Shared Neighborhood Hits	34
SwissProt Accessions	Q62177	Gene names	Sema3b, Sema, Semaa
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin A) (Sema A).

ZN207_HUMAN
NC score	0.018912 (rank : 1576)	θ value	4.03905 (rank : 1692)
Query Neighborhood Hits	1931	Target Neighborhood Hits	326	Shared Neighborhood Hits	77
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

NRX2B_HUMAN
NC score	0.018594 (rank : 1577)	θ value	2.36792 (rank : 1562)
Query Neighborhood Hits	1931	Target Neighborhood Hits	481	Shared Neighborhood Hits	173
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

RFX1_HUMAN
NC score	0.018495 (rank : 1578)	θ value	0.62314 (rank : 1349)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	89
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

WASF2_MOUSE
NC score	0.018481 (rank : 1579)	θ value	6.88961 (rank : 1813)
Query Neighborhood Hits	1931	Target Neighborhood Hits	315	Shared Neighborhood Hits	111
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

MYO15_HUMAN
NC score	0.018187 (rank : 1580)	θ value	8.99809 (rank : 1883)
Query Neighborhood Hits	1931	Target Neighborhood Hits	671	Shared Neighborhood Hits	228
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

HPLN2_HUMAN
NC score	0.018177 (rank : 1581)	θ value	0.813845 (rank : 1375)
Query Neighborhood Hits	1931	Target Neighborhood Hits	80	Shared Neighborhood Hits	47
SwissProt Accessions	Q9GZV7	Gene names	HAPLN2, BRAL1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

LIPS_HUMAN
NC score	0.018163 (rank : 1582)	θ value	8.99809 (rank : 1876)
Query Neighborhood Hits	1931	Target Neighborhood Hits	314	Shared Neighborhood Hits	106
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

BAZ2A_HUMAN
NC score	0.017941 (rank : 1583)	θ value	1.81305 (rank : 1483)
Query Neighborhood Hits	1931	Target Neighborhood Hits	780	Shared Neighborhood Hits	199
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

MY116_MOUSE
NC score	0.017832 (rank : 1584)	θ value	1.06291 (rank : 1414)
Query Neighborhood Hits	1931	Target Neighborhood Hits	70	Shared Neighborhood Hits	18
SwissProt Accessions	P17564	Gene names	Myd116
Domain Architecture	No domain graphic available
Description	Myeloid differentiation primary response protein MyD116.

IGHE_HUMAN
NC score	0.017631 (rank : 1585)	θ value	6.88961 (rank : 1784)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	58
SwissProt Accessions	P01854	Gene names	IGHE
Domain Architecture
Description	Ig epsilon chain C region.

PDC6I_HUMAN
NC score	0.017607 (rank : 1586)	θ value	1.06291 (rank : 1416)
Query Neighborhood Hits	1931	Target Neighborhood Hits	278	Shared Neighborhood Hits	87
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

BTNL8_HUMAN
NC score	0.017584 (rank : 1587)	θ value	6.88961 (rank : 1757)
Query Neighborhood Hits	1931	Target Neighborhood Hits	177	Shared Neighborhood Hits	73
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

PDZD2_HUMAN
NC score	0.017568 (rank : 1588)	θ value	0.813845 (rank : 1386)
Query Neighborhood Hits	1931	Target Neighborhood Hits	772	Shared Neighborhood Hits	189
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

K1802_HUMAN
NC score	0.017524 (rank : 1589)	θ value	0.62314 (rank : 1339)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1378	Shared Neighborhood Hits	273
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

PHC2_HUMAN
NC score	0.017497 (rank : 1590)	θ value	8.99809 (rank : 1891)
Query Neighborhood Hits	1931	Target Neighborhood Hits	388	Shared Neighborhood Hits	136
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

IRS2_MOUSE
NC score	0.017417 (rank : 1591)	θ value	6.88961 (rank : 1785)
Query Neighborhood Hits	1931	Target Neighborhood Hits	248	Shared Neighborhood Hits	91
SwissProt Accessions	P81122	Gene names	Irs2
Domain Architecture	No domain graphic available
Description	Insulin receptor substrate 2 (IRS-2) (4PS).

HPLN4_MOUSE
NC score	0.017292 (rank : 1592)	θ value	6.88961 (rank : 1780)
Query Neighborhood Hits	1931	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q80WM4, Q80XX2	Gene names	Hapln4, Bral2, Lpr4
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2) (Link protein 4).

TTDN1_MOUSE
NC score	0.017253 (rank : 1593)	θ value	0.813845 (rank : 1393)
Query Neighborhood Hits	1931	Target Neighborhood Hits	26	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D011	Gene names	Ttdn1
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein homolog.

NELFA_MOUSE
NC score	0.017192 (rank : 1594)	θ value	2.36792 (rank : 1559)
Query Neighborhood Hits	1931	Target Neighborhood Hits	195	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9	Gene names	Whsc2, Nelfa, Whsc2h
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2).

EPN1_MOUSE
NC score	0.017116 (rank : 1595)	θ value	6.88961 (rank : 1771)
Query Neighborhood Hits	1931	Target Neighborhood Hits	240	Shared Neighborhood Hits	90
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

ECM1_HUMAN
NC score	0.016840 (rank : 1596)	θ value	8.99809 (rank : 1846)
Query Neighborhood Hits	1931	Target Neighborhood Hits	182	Shared Neighborhood Hits	77
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

I28RA_MOUSE
NC score	0.016796 (rank : 1597)	θ value	0.0431538 (rank : 1119)
Query Neighborhood Hits	1931	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CGK5, Q6PEV1	Gene names	Il28ra, Ifnlr1
Domain Architecture	No domain graphic available
Description	Interleukin-28 receptor alpha chain precursor (IL-28R-alpha) (IL-28RA) (Cytokine receptor family 2 member 12) (Cytokine receptor class-II member 12) (CRF2-12) (Interferon lambda receptor 1) (IFN-lambda R1).

AMELX_HUMAN
NC score	0.016755 (rank : 1598)	θ value	1.38821 (rank : 1435)
Query Neighborhood Hits	1931	Target Neighborhood Hits	95	Shared Neighborhood Hits	35
SwissProt Accessions	Q99217, Q96NW6, Q9UCA7	Gene names	AMELX, AMG, AMGX
Domain Architecture
Description	Amelogenin, X isoform precursor.

CO3A1_HUMAN
NC score	0.016700 (rank : 1599)	θ value	0.0431538 (rank : 1116)
Query Neighborhood Hits	1931	Target Neighborhood Hits	452	Shared Neighborhood Hits	146
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

SEM3E_HUMAN
NC score	0.016655 (rank : 1600)	θ value	8.99809 (rank : 1903)
Query Neighborhood Hits	1931	Target Neighborhood Hits	73	Shared Neighborhood Hits	31
SwissProt Accessions	O15041, Q75M94, Q75M97	Gene names	SEMA3E, KIAA0331
Domain Architecture	No domain graphic available
Description	Semaphorin-3E precursor.

BRD4_HUMAN
NC score	0.016541 (rank : 1601)	θ value	8.99809 (rank : 1828)
Query Neighborhood Hits	1931	Target Neighborhood Hits	851	Shared Neighborhood Hits	190
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

MYO15_MOUSE
NC score	0.016505 (rank : 1602)	θ value	0.62314 (rank : 1342)
Query Neighborhood Hits	1931	Target Neighborhood Hits	467	Shared Neighborhood Hits	162
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

SMCA4_HUMAN
NC score	0.016174 (rank : 1603)	θ value	0.62314 (rank : 1352)
Query Neighborhood Hits	1931	Target Neighborhood Hits	597	Shared Neighborhood Hits	157
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

CPSF6_MOUSE
NC score	0.016163 (rank : 1604)	θ value	6.88961 (rank : 1765)
Query Neighborhood Hits	1931	Target Neighborhood Hits	356	Shared Neighborhood Hits	122
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

HCN2_HUMAN
NC score	0.015918 (rank : 1605)	θ value	2.36792 (rank : 1548)
Query Neighborhood Hits	1931	Target Neighborhood Hits	369	Shared Neighborhood Hits	135
SwissProt Accessions	Q9UL51, O60742, O60743, O75267, Q9UBS2	Gene names	HCN2, BCNG2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2).

CJ026_MOUSE
NC score	0.015709 (rank : 1606)	θ value	0.0736092 (rank : 1147)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BGW2, Q3TF48, Q3U3M2, Q6PD43, Q8R0W8	Gene names	D19Wsu162e
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C10orf26 homolog.

CPSF6_HUMAN
NC score	0.015637 (rank : 1607)	θ value	6.88961 (rank : 1764)
Query Neighborhood Hits	1931	Target Neighborhood Hits	359	Shared Neighborhood Hits	119
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

HAX1_MOUSE
NC score	0.015629 (rank : 1608)	θ value	0.163984 (rank : 1210)
Query Neighborhood Hits	1931	Target Neighborhood Hits	27	Shared Neighborhood Hits	6
SwissProt Accessions	O35387	Gene names	Hax1, Hs1bp1
Domain Architecture	No domain graphic available
Description	HS1-associating protein X-1 (HAX-1) (HS1-binding protein).

CD8A_HUMAN
NC score	0.015619 (rank : 1609)	θ value	4.03905 (rank : 1629)
Query Neighborhood Hits	1931	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	P01732, Q13970	Gene names	CD8A, MAL
Domain Architecture
Description	T-cell surface glycoprotein CD8 alpha chain precursor (T-lymphocyte differentiation antigen T8/Leu-2) (CD8a antigen).

RTN1_MOUSE
NC score	0.015495 (rank : 1610)	θ value	5.27518 (rank : 1736)
Query Neighborhood Hits	1931	Target Neighborhood Hits	189	Shared Neighborhood Hits	67
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

CO3A1_MOUSE
NC score	0.015449 (rank : 1611)	θ value	0.0961366 (rank : 1170)
Query Neighborhood Hits	1931	Target Neighborhood Hits	466	Shared Neighborhood Hits	149
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

TTDN1_HUMAN
NC score	0.015233 (rank : 1612)	θ value	6.88961 (rank : 1808)
Query Neighborhood Hits	1931	Target Neighborhood Hits	43	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TAP9	Gene names	TTDN1, C7orf11
Domain Architecture	No domain graphic available
Description	TTD non-photosensitive 1 protein.

INVS_MOUSE
NC score	0.015218 (rank : 1613)	θ value	0.279714 (rank : 1252)
Query Neighborhood Hits	1931	Target Neighborhood Hits	609	Shared Neighborhood Hits	139
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

CS007_HUMAN
NC score	0.015098 (rank : 1614)	θ value	3.0926 (rank : 1585)
Query Neighborhood Hits	1931	Target Neighborhood Hits	401	Shared Neighborhood Hits	121
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

CO1A1_MOUSE
NC score	0.014984 (rank : 1615)	θ value	1.38821 (rank : 1441)
Query Neighborhood Hits	1931	Target Neighborhood Hits	457	Shared Neighborhood Hits	146
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

DAB1_HUMAN
NC score	0.014856 (rank : 1616)	θ value	0.279714 (rank : 1246)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	96
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

AUTS2_HUMAN
NC score	0.014846 (rank : 1617)	θ value	6.88961 (rank : 1753)
Query Neighborhood Hits	1931	Target Neighborhood Hits	342	Shared Neighborhood Hits	102
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

PSD4_HUMAN
NC score	0.014825 (rank : 1618)	θ value	0.365318 (rank : 1290)
Query Neighborhood Hits	1931	Target Neighborhood Hits	178	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

SREC2_HUMAN
NC score	0.014734 (rank : 1619)	θ value	8.99809 (rank : 1910)
Query Neighborhood Hits	1931	Target Neighborhood Hits	645	Shared Neighborhood Hits	114
SwissProt Accessions	Q96GP6, Q8IXF3, Q9BW74	Gene names	SCARF2, SREC2, SREPCR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II) (SRECRP-1).

SEM4B_HUMAN
NC score	0.014704 (rank : 1620)	θ value	0.47712 (rank : 1314)
Query Neighborhood Hits	1931	Target Neighborhood Hits	67	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NPR2, Q6UXE3, Q8WVP9, Q96FK5, Q9C0B8, Q9H691, Q9NPM8, Q9NPN0	Gene names	SEMA4B, KIAA1745
Domain Architecture
Description	Semaphorin-4B precursor.

IL3RB_MOUSE
NC score	0.014480 (rank : 1621)	θ value	8.99809 (rank : 1866)
Query Neighborhood Hits	1931	Target Neighborhood Hits	355	Shared Neighborhood Hits	143
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

TACC3_HUMAN
NC score	0.014079 (rank : 1622)	θ value	8.99809 (rank : 1914)
Query Neighborhood Hits	1931	Target Neighborhood Hits	779	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

ERMAP_MOUSE
NC score	0.013925 (rank : 1623)	θ value	3.0926 (rank : 1589)
Query Neighborhood Hits	1931	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q9JLN5, Q3UV82, Q6P4T5, Q8CEH1	Gene names	Ermap
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor.

CO1A1_HUMAN
NC score	0.013924 (rank : 1624)	θ value	0.62314 (rank : 1330)
Query Neighborhood Hits	1931	Target Neighborhood Hits	475	Shared Neighborhood Hits	146
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

SEM6B_MOUSE
NC score	0.013857 (rank : 1625)	θ value	8.99809 (rank : 1904)
Query Neighborhood Hits	1931	Target Neighborhood Hits	200	Shared Neighborhood Hits	91
SwissProt Accessions	O54951	Gene names	Sema6b, Seman
Domain Architecture
Description	Semaphorin-6B precursor (Semaphorin VIB) (Sema VIB) (Semaphorin N) (Sema N).

FXL19_HUMAN
NC score	0.013853 (rank : 1626)	θ value	0.00665767 (rank : 1038)
Query Neighborhood Hits	1931	Target Neighborhood Hits	147	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

CCDC9_HUMAN
NC score	0.013805 (rank : 1627)	θ value	0.813845 (rank : 1365)
Query Neighborhood Hits	1931	Target Neighborhood Hits	175	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y3X0	Gene names	CCDC9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

EVPL_HUMAN
NC score	0.013706 (rank : 1628)	θ value	0.279714 (rank : 1248)
Query Neighborhood Hits	1931	Target Neighborhood Hits	895	Shared Neighborhood Hits	95
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

NCOR1_MOUSE
NC score	0.013557 (rank : 1629)	θ value	5.27518 (rank : 1730)
Query Neighborhood Hits	1931	Target Neighborhood Hits	521	Shared Neighborhood Hits	99
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

CIZ1_HUMAN
NC score	0.013483 (rank : 1630)	θ value	5.27518 (rank : 1704)
Query Neighborhood Hits	1931	Target Neighborhood Hits	359	Shared Neighborhood Hits	91
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

SEM4B_MOUSE
NC score	0.013470 (rank : 1631)	θ value	5.27518 (rank : 1737)
Query Neighborhood Hits	1931	Target Neighborhood Hits	67	Shared Neighborhood Hits	27
SwissProt Accessions	Q62179, Q4PKI6, Q69ZB7	Gene names	Sema4b, Kiaa1745, Semac, SemC
Domain Architecture	No domain graphic available
Description	Semaphorin-4B precursor (Semaphorin C) (Sema C).

ZIMP7_MOUSE
NC score	0.013447 (rank : 1632)	θ value	8.99809 (rank : 1927)
Query Neighborhood Hits	1931	Target Neighborhood Hits	566	Shared Neighborhood Hits	206
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

LAMA5_HUMAN
NC score	0.013395 (rank : 1633)	θ value	2.36792 (rank : 1551)
Query Neighborhood Hits	1931	Target Neighborhood Hits	976	Shared Neighborhood Hits	157
SwissProt Accessions	O15230, Q8WZA7, Q9H1P1	Gene names	LAMA5, KIAA0533, KIAA1907
Domain Architecture
Description	Laminin alpha-5 chain precursor.

CO4A4_HUMAN
NC score	0.013381 (rank : 1634)	θ value	2.36792 (rank : 1533)
Query Neighborhood Hits	1931	Target Neighborhood Hits	440	Shared Neighborhood Hits	156
SwissProt Accessions	P53420	Gene names	COL4A4
Domain Architecture
Description	Collagen alpha-4(IV) chain precursor.

SPAG8_HUMAN
NC score	0.013367 (rank : 1635)	θ value	1.81305 (rank : 1512)
Query Neighborhood Hits	1931	Target Neighborhood Hits	56	Shared Neighborhood Hits	24
SwissProt Accessions	Q99932, Q12937, Q5TCV8, Q8WWB4	Gene names	SPAG8
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 8 (Sperm membrane protein 1) (SMP-1) (HSD-1) (Sperm membrane protein BS-84).

NUMBL_HUMAN
NC score	0.013291 (rank : 1636)	θ value	5.27518 (rank : 1731)
Query Neighborhood Hits	1931	Target Neighborhood Hits	394	Shared Neighborhood Hits	136
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

FYCO1_HUMAN
NC score	0.013189 (rank : 1637)	θ value	0.279714 (rank : 1249)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1149	Shared Neighborhood Hits	116
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

INVS_HUMAN
NC score	0.013132 (rank : 1638)	θ value	0.279714 (rank : 1251)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

CECR2_HUMAN
NC score	0.012991 (rank : 1639)	θ value	4.03905 (rank : 1630)
Query Neighborhood Hits	1931	Target Neighborhood Hits	543	Shared Neighborhood Hits	164
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

BAI1_HUMAN
NC score	0.012989 (rank : 1640)	θ value	3.0926 (rank : 1578)
Query Neighborhood Hits	1931	Target Neighborhood Hits	375	Shared Neighborhood Hits	90
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

PKHA4_HUMAN
NC score	0.012981 (rank : 1641)	θ value	8.99809 (rank : 1892)
Query Neighborhood Hits	1931	Target Neighborhood Hits	283	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SEM4F_MOUSE
NC score	0.012894 (rank : 1642)	θ value	4.03905 (rank : 1680)
Query Neighborhood Hits	1931	Target Neighborhood Hits	59	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z123, Q9R1Y1	Gene names	Sema4f, Semaw
Domain Architecture
Description	Semaphorin-4F precursor (Semaphorin W) (Sema W).

NIN_HUMAN
NC score	0.012805 (rank : 1643)	θ value	8.99809 (rank : 1884)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1416	Shared Neighborhood Hits	134
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

LAMA5_MOUSE
NC score	0.012773 (rank : 1644)	θ value	1.06291 (rank : 1410)
Query Neighborhood Hits	1931	Target Neighborhood Hits	828	Shared Neighborhood Hits	110
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

IGX1_HUMAN
NC score	0.012662 (rank : 1645)	θ value	3.0926 (rank : 1598)
Query Neighborhood Hits	1931	Target Neighborhood Hits	36	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TAG5	Gene names
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain protein MGC33530 precursor.

ENAM_MOUSE
NC score	0.012628 (rank : 1646)	θ value	1.81305 (rank : 1492)
Query Neighborhood Hits	1931	Target Neighborhood Hits	229	Shared Neighborhood Hits	73
SwissProt Accessions	O55196	Gene names	Enam
Domain Architecture	No domain graphic available
Description	Enamelin precursor.

JIP2_MOUSE
NC score	0.012596 (rank : 1647)	θ value	1.81305 (rank : 1496)
Query Neighborhood Hits	1931	Target Neighborhood Hits	144	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

CO5A2_HUMAN
NC score	0.012577 (rank : 1648)	θ value	1.81305 (rank : 1488)
Query Neighborhood Hits	1931	Target Neighborhood Hits	760	Shared Neighborhood Hits	211
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

COFA1_HUMAN
NC score	0.012558 (rank : 1649)	θ value	0.47712 (rank : 1301)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	98
SwissProt Accessions	P39059, Q5T6J4, Q9Y4W4	Gene names	COL15A1
Domain Architecture
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV) (Restin) (Related to endostatin)].

COIA1_HUMAN
NC score	0.012556 (rank : 1650)	θ value	3.0926 (rank : 1584)
Query Neighborhood Hits	1931	Target Neighborhood Hits	447	Shared Neighborhood Hits	155
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

GON4L_MOUSE
NC score	0.012537 (rank : 1651)	θ value	1.38821 (rank : 1451)
Query Neighborhood Hits	1931	Target Neighborhood Hits	455	Shared Neighborhood Hits	108
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

FMNL_MOUSE
NC score	0.012529 (rank : 1652)	θ value	8.99809 (rank : 1852)
Query Neighborhood Hits	1931	Target Neighborhood Hits	428	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

MYCB2_HUMAN
NC score	0.012366 (rank : 1653)	θ value	5.27518 (rank : 1729)
Query Neighborhood Hits	1931	Target Neighborhood Hits	390	Shared Neighborhood Hits	61
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

CMTA2_MOUSE
NC score	0.012300 (rank : 1654)	θ value	2.36792 (rank : 1531)
Query Neighborhood Hits	1931	Target Neighborhood Hits	216	Shared Neighborhood Hits	51
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

RBM12_HUMAN
NC score	0.012243 (rank : 1655)	θ value	1.38821 (rank : 1462)
Query Neighborhood Hits	1931	Target Neighborhood Hits	298	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NTZ6, O94865, Q8N3B1, Q9H196	Gene names	RBM12, KIAA0765
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

ARMX2_HUMAN
NC score	0.012144 (rank : 1656)	θ value	2.36792 (rank : 1524)
Query Neighborhood Hits	1931	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q7L311, O60267, Q5H9D9	Gene names	ARMCX2, ALEX2, KIAA0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2 (Protein ALEX2) (ARM protein lost in epithelial cancers on chromosome X 2).

HCN2_MOUSE
NC score	0.012142 (rank : 1657)	θ value	3.0926 (rank : 1592)
Query Neighborhood Hits	1931	Target Neighborhood Hits	278	Shared Neighborhood Hits	105
SwissProt Accessions	O88703, O70506	Gene names	Hcn2, Bcng2, Hac1
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Brain cyclic nucleotide-gated channel 2) (BCNG-2) (Hyperpolarization-activated cation channel 1) (HAC-1).

HMMR_HUMAN
NC score	0.012102 (rank : 1658)	θ value	5.27518 (rank : 1715)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1082	Shared Neighborhood Hits	90
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

CBX2_HUMAN
NC score	0.011981 (rank : 1659)	θ value	2.36792 (rank : 1528)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	93
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

BIN1_MOUSE
NC score	0.011959 (rank : 1660)	θ value	8.99809 (rank : 1825)
Query Neighborhood Hits	1931	Target Neighborhood Hits	283	Shared Neighborhood Hits	79
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

LRC41_HUMAN
NC score	0.011895 (rank : 1661)	θ value	0.21417 (rank : 1234)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	9
SwissProt Accessions	Q15345, Q71RA8, Q9BSM0	Gene names	LRRC41, MUF1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 41 (Protein Muf1).

EMID2_HUMAN
NC score	0.011876 (rank : 1662)	θ value	1.06291 (rank : 1404)
Query Neighborhood Hits	1931	Target Neighborhood Hits	226	Shared Neighborhood Hits	91
SwissProt Accessions	Q96A83	Gene names	EMID2, COL26A1, EMU2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

TRML2_HUMAN
NC score	0.011798 (rank : 1663)	θ value	2.36792 (rank : 1571)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q5T2D2, Q8IWY0, Q9H8E9	Gene names	TREML2, C6orf76, TLT2
Domain Architecture	No domain graphic available
Description	Trem-like transcript 2 protein precursor (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2).

3BP1_HUMAN
NC score	0.011678 (rank : 1664)	θ value	4.03905 (rank : 1620)
Query Neighborhood Hits	1931	Target Neighborhood Hits	376	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

TNR4_HUMAN
NC score	0.011645 (rank : 1665)	θ value	0.47712 (rank : 1320)
Query Neighborhood Hits	1931	Target Neighborhood Hits	152	Shared Neighborhood Hits	34
SwissProt Accessions	P43489, Q13663, Q5T7M0	Gene names	TNFRSF4, TXGP1L
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 4 precursor (OX40L receptor) (ACT35 antigen) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD134 antigen).

CROCC_HUMAN
NC score	0.011555 (rank : 1666)	θ value	6.88961 (rank : 1766)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1409	Shared Neighborhood Hits	135
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CTND2_HUMAN
NC score	0.011545 (rank : 1667)	θ value	4.03905 (rank : 1642)
Query Neighborhood Hits	1931	Target Neighborhood Hits	333	Shared Neighborhood Hits	110
SwissProt Accessions	Q9UQB3, O00379, O15390, O43206, O43840, Q13589, Q9UM66, Q9UPM3	Gene names	CTNND2, NPRAP
Domain Architecture
Description	Catenin delta-2 (Delta-catenin) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin) (GT24).

DC1L2_MOUSE
NC score	0.011518 (rank : 1668)	θ value	5.27518 (rank : 1709)
Query Neighborhood Hits	1931	Target Neighborhood Hits	173	Shared Neighborhood Hits	67
SwissProt Accessions	Q6PDL0	Gene names	Dync1li2, Dncli2, Dnclic2
Domain Architecture	No domain graphic available
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic).

T22D4_MOUSE
NC score	0.011509 (rank : 1669)	θ value	1.38821 (rank : 1472)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EQN3	Gene names	Tsc22d4, Tilz2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2).

COHA1_MOUSE
NC score	0.011459 (rank : 1670)	θ value	6.88961 (rank : 1763)
Query Neighborhood Hits	1931	Target Neighborhood Hits	414	Shared Neighborhood Hits	136
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

IGX1_MOUSE
NC score	0.011349 (rank : 1671)	θ value	8.99809 (rank : 1865)
Query Neighborhood Hits	1931	Target Neighborhood Hits	44	Shared Neighborhood Hits	26
SwissProt Accessions	Q8R0A6	Gene names
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain protein MGC33530 precursor.

DIAP2_HUMAN
NC score	0.011082 (rank : 1672)	θ value	0.0736092 (rank : 1148)
Query Neighborhood Hits	1931	Target Neighborhood Hits	342	Shared Neighborhood Hits	72
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

CK042_HUMAN
NC score	0.010935 (rank : 1673)	θ value	2.36792 (rank : 1529)
Query Neighborhood Hits	1931	Target Neighborhood Hits	22	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N5U0	Gene names	C11orf42
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf42.

CTTB2_HUMAN
NC score	0.010921 (rank : 1674)	θ value	1.81305 (rank : 1489)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1061	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

SSPO_MOUSE
NC score	0.010847 (rank : 1675)	θ value	8.99809 (rank : 1911)
Query Neighborhood Hits	1931	Target Neighborhood Hits	800	Shared Neighborhood Hits	115
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

COIA1_MOUSE
NC score	0.010810 (rank : 1676)	θ value	2.36792 (rank : 1536)
Query Neighborhood Hits	1931	Target Neighborhood Hits	481	Shared Neighborhood Hits	143
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

BRD8_MOUSE
NC score	0.010707 (rank : 1677)	θ value	1.06291 (rank : 1400)
Query Neighborhood Hits	1931	Target Neighborhood Hits	422	Shared Neighborhood Hits	90
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

VGF_HUMAN
NC score	0.010623 (rank : 1678)	θ value	4.03905 (rank : 1690)
Query Neighborhood Hits	1931	Target Neighborhood Hits	167	Shared Neighborhood Hits	30
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

HAX1_HUMAN
NC score	0.010532 (rank : 1679)	θ value	4.03905 (rank : 1654)
Query Neighborhood Hits	1931	Target Neighborhood Hits	28	Shared Neighborhood Hits	7
SwissProt Accessions	O00165, Q96AU4, Q9BS80	Gene names	HAX1, HS1BP1
Domain Architecture	No domain graphic available
Description	HS1-associating protein X-1 (HAX-1) (HS1-binding protein).

EP400_HUMAN
NC score	0.010519 (rank : 1680)	θ value	5.27518 (rank : 1711)
Query Neighborhood Hits	1931	Target Neighborhood Hits	556	Shared Neighborhood Hits	152
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

PER1_HUMAN
NC score	0.010381 (rank : 1681)	θ value	0.365318 (rank : 1288)
Query Neighborhood Hits	1931	Target Neighborhood Hits	215	Shared Neighborhood Hits	69
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

CD248_MOUSE
NC score	0.010374 (rank : 1682)	θ value	6.88961 (rank : 1759)
Query Neighborhood Hits	1931	Target Neighborhood Hits	578	Shared Neighborhood Hits	141
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

ASPM_HUMAN
NC score	0.010352 (rank : 1683)	θ value	1.81305 (rank : 1481)
Query Neighborhood Hits	1931	Target Neighborhood Hits	197	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IZT6, Q86UX4, Q8IUL2, Q8IZJ7, Q8IZJ8, Q8IZJ9, Q8N4D1, Q9NVS1, Q9NVT6	Gene names	ASPM, MCPH5
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog).

IL4RA_MOUSE
NC score	0.010325 (rank : 1684)	θ value	5.27518 (rank : 1719)
Query Neighborhood Hits	1931	Target Neighborhood Hits	194	Shared Neighborhood Hits	82
SwissProt Accessions	P16382, O54690, Q60583, Q8CBW5	Gene names	Il4r, Il4ra
Domain Architecture
Description	Interleukin-4 receptor alpha chain precursor (IL-4R-alpha) (CD124 antigen) [Contains: Soluble interleukin-4 receptor alpha chain (IL-4- binding protein) (IL4-BP)].

SPRR3_MOUSE
NC score	0.010293 (rank : 1685)	θ value	4.03905 (rank : 1683)
Query Neighborhood Hits	1931	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	O09116	Gene names	Sprr3
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta).

CSPG4_MOUSE
NC score	0.010251 (rank : 1686)	θ value	0.125558 (rank : 1187)
Query Neighborhood Hits	1931	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VHY0, Q5DTG1, Q8BPI8, Q8CE79	Gene names	Cspg4, An2, Kiaa4232, Ng2
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (AN2 proteoglycan).

NFAC1_HUMAN
NC score	0.010217 (rank : 1687)	θ value	4.03905 (rank : 1670)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	100
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

CO4A3_HUMAN
NC score	0.010171 (rank : 1688)	θ value	0.813845 (rank : 1369)
Query Neighborhood Hits	1931	Target Neighborhood Hits	421	Shared Neighborhood Hits	146
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

COFA1_MOUSE
NC score	0.009924 (rank : 1689)	θ value	1.06291 (rank : 1402)
Query Neighborhood Hits	1931	Target Neighborhood Hits	305	Shared Neighborhood Hits	108
SwissProt Accessions	O35206, Q9EQD9	Gene names	Col15a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XV) chain precursor [Contains: Endostatin (Endostatin-XV)].

NEB2_MOUSE
NC score	0.009865 (rank : 1690)	θ value	6.88961 (rank : 1792)
Query Neighborhood Hits	1931	Target Neighborhood Hits	889	Shared Neighborhood Hits	102
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

IP3KA_HUMAN
NC score	0.009838 (rank : 1691)	θ value	0.0736092 (rank : 1152)
Query Neighborhood Hits	1931	Target Neighborhood Hits	60	Shared Neighborhood Hits	16
SwissProt Accessions	P23677, Q8TAN3	Gene names	ITPKA
Domain Architecture
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

CMTA2_HUMAN
NC score	0.009697 (rank : 1692)	θ value	2.36792 (rank : 1530)
Query Neighborhood Hits	1931	Target Neighborhood Hits	199	Shared Neighborhood Hits	49
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

F100A_MOUSE
NC score	0.009608 (rank : 1693)	θ value	0.813845 (rank : 1372)
Query Neighborhood Hits	1931	Target Neighborhood Hits	26	Shared Neighborhood Hits	9
SwissProt Accessions	Q6P3B2	Gene names	Fam100a
Domain Architecture	No domain graphic available
Description	Protein FAM100A.

PER1_MOUSE
NC score	0.009569 (rank : 1694)	θ value	4.03905 (rank : 1673)
Query Neighborhood Hits	1931	Target Neighborhood Hits	235	Shared Neighborhood Hits	90
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

CMTA1_HUMAN
NC score	0.009563 (rank : 1695)	θ value	3.0926 (rank : 1582)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

AB1IP_MOUSE
NC score	0.009485 (rank : 1696)	θ value	3.0926 (rank : 1576)
Query Neighborhood Hits	1931	Target Neighborhood Hits	181	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

STAP2_HUMAN
NC score	0.009441 (rank : 1697)	θ value	4.03905 (rank : 1685)
Query Neighborhood Hits	1931	Target Neighborhood Hits	29	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UGK3, Q9NXI2	Gene names	STAP2, BKS
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate).

CO4A1_MOUSE
NC score	0.009401 (rank : 1698)	θ value	2.36792 (rank : 1532)
Query Neighborhood Hits	1931	Target Neighborhood Hits	450	Shared Neighborhood Hits	157
SwissProt Accessions	P02463	Gene names	Col4a1
Domain Architecture
Description	Collagen alpha-1(IV) chain precursor.

RBM13_MOUSE
NC score	0.009326 (rank : 1699)	θ value	1.06291 (rank : 1422)
Query Neighborhood Hits	1931	Target Neighborhood Hits	63	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BGS0, Q921E0, Q9D5G6	Gene names	Rbm13
Domain Architecture	No domain graphic available
Description	MAK16-like protein RBM13 (RNA-binding motif protein 13).

CSPG4_HUMAN
NC score	0.009157 (rank : 1700)	θ value	4.03905 (rank : 1641)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	19
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

REXO1_MOUSE
NC score	0.009157 (rank : 1701)	θ value	0.62314 (rank : 1348)
Query Neighborhood Hits	1931	Target Neighborhood Hits	166	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TT28, Q3UMP1, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29	Gene names	Rexo1, Kiaa1138, Tceb3bp1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Transcription elongation factor B polypeptide 3-binding protein 1).

CO2A1_MOUSE
NC score	0.009128 (rank : 1702)	θ value	8.99809 (rank : 1838)
Query Neighborhood Hits	1931	Target Neighborhood Hits	483	Shared Neighborhood Hits	163
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

UB7I1_MOUSE
NC score	0.009094 (rank : 1703)	θ value	1.81305 (rank : 1516)
Query Neighborhood Hits	1931	Target Neighborhood Hits	206	Shared Neighborhood Hits	67
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

IGHG1_MOUSE
NC score	0.009050 (rank : 1704)	θ value	3.0926 (rank : 1597)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	49
SwissProt Accessions	P01868	Gene names
Domain Architecture
Description	Ig gamma-1 chain C region secreted form.

HPLN1_HUMAN
NC score	0.008972 (rank : 1705)	θ value	4.03905 (rank : 1655)
Query Neighborhood Hits	1931	Target Neighborhood Hits	67	Shared Neighborhood Hits	39
SwissProt Accessions	P10915	Gene names	HAPLN1, CRTL1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 1 precursor (Proteoglycan link protein) (Cartilage link protein) (LP).

GR65_MOUSE
NC score	0.008933 (rank : 1706)	θ value	0.21417 (rank : 1229)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	18
SwissProt Accessions	Q91X51, Q9D3L9	Gene names	Gorasp1
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65).

GAK4_HUMAN
NC score	0.008881 (rank : 1707)	θ value	6.88961 (rank : 1776)
Query Neighborhood Hits	1931	Target Neighborhood Hits	415	Shared Neighborhood Hits	153
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

IGH1M_MOUSE
NC score	0.008865 (rank : 1708)	θ value	3.0926 (rank : 1596)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	49
SwissProt Accessions	P01869	Gene names
Domain Architecture	No domain graphic available
Description	Ig gamma-1 chain C region, membrane-bound form.

LBXCO_HUMAN
NC score	0.008769 (rank : 1709)	θ value	1.06291 (rank : 1411)
Query Neighborhood Hits	1931	Target Neighborhood Hits	167	Shared Neighborhood Hits	47
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

COBA2_HUMAN
NC score	0.008723 (rank : 1710)	θ value	1.38821 (rank : 1442)
Query Neighborhood Hits	1931	Target Neighborhood Hits	408	Shared Neighborhood Hits	131
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

GGA1_HUMAN
NC score	0.008705 (rank : 1711)	θ value	4.03905 (rank : 1652)
Query Neighborhood Hits	1931	Target Neighborhood Hits	169	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UJY5, Q5TG07, Q9BW94, Q9UG00, Q9UGW0, Q9UGW1	Gene names	GGA1
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

NSD1_MOUSE
NC score	0.008685 (rank : 1712)	θ value	0.813845 (rank : 1385)
Query Neighborhood Hits	1931	Target Neighborhood Hits	472	Shared Neighborhood Hits	102
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

CLIC6_HUMAN
NC score	0.008675 (rank : 1713)	θ value	3.0926 (rank : 1581)
Query Neighborhood Hits	1931	Target Neighborhood Hits	289	Shared Neighborhood Hits	77
SwissProt Accessions	Q96NY7, Q8IX31	Gene names	CLIC6, CLIC1L
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

COBA2_MOUSE
NC score	0.008598 (rank : 1714)	θ value	3.0926 (rank : 1583)
Query Neighborhood Hits	1931	Target Neighborhood Hits	501	Shared Neighborhood Hits	153
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

DEDD2_HUMAN
NC score	0.008581 (rank : 1715)	θ value	0.279714 (rank : 1247)
Query Neighborhood Hits	1931	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WXF8, Q8NBR2, Q8NES1, Q8TAA8, Q96D35	Gene names	DEDD2, FLAME3
Domain Architecture	No domain graphic available
Description	DNA-binding death effector domain-containing protein 2 (FADD-like anti-apoptotic molecule 3) (DED-containing protein FLAME-3).

PX11C_MOUSE
NC score	0.008577 (rank : 1716)	θ value	1.06291 (rank : 1421)
Query Neighborhood Hits	1931	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q6P6M5, Q9D8P0, Q9D8X4	Gene names	Pex11g, Pex11c
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein 11C (Peroxin-11C) (Peroxisomal biogenesis factor 11C) (PEX11gamma) (Pex11pgamma).

LV4C_HUMAN
NC score	0.008346 (rank : 1717)	θ value	1.38821 (rank : 1458)
Query Neighborhood Hits	1931	Target Neighborhood Hits	284	Shared Neighborhood Hits	87
SwissProt Accessions	P01717	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-IV region Hil.

ADDA_MOUSE
NC score	0.008309 (rank : 1718)	θ value	4.03905 (rank : 1622)
Query Neighborhood Hits	1931	Target Neighborhood Hits	198	Shared Neighborhood Hits	63
SwissProt Accessions	Q9QYC0, Q9JLE3	Gene names	Add1
Domain Architecture
Description	Alpha-adducin (Erythrocyte adducin subunit alpha).

HSF1_HUMAN
NC score	0.008247 (rank : 1719)	θ value	3.0926 (rank : 1593)
Query Neighborhood Hits	1931	Target Neighborhood Hits	163	Shared Neighborhood Hits	54
SwissProt Accessions	Q00613	Gene names	HSF1, HSTF1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

TNC6B_HUMAN
NC score	0.008221 (rank : 1720)	θ value	4.03905 (rank : 1689)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

EMID1_MOUSE
NC score	0.008108 (rank : 1721)	θ value	1.38821 (rank : 1449)
Query Neighborhood Hits	1931	Target Neighborhood Hits	230	Shared Neighborhood Hits	86
SwissProt Accessions	Q91VF5	Gene names	Emid1, Emu1
Domain Architecture	No domain graphic available
Description	EMI domain-containing protein 1 precursor (Protein Emu1) (Emilin and multimerin domain-containing protein 1).

LIPA3_MOUSE
NC score	0.008101 (rank : 1722)	θ value	4.03905 (rank : 1663)
Query Neighborhood Hits	1931	Target Neighborhood Hits	636	Shared Neighborhood Hits	70
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

FHOD1_MOUSE
NC score	0.007993 (rank : 1723)	θ value	2.36792 (rank : 1542)
Query Neighborhood Hits	1931	Target Neighborhood Hits	217	Shared Neighborhood Hits	70
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

DUS8_HUMAN
NC score	0.007988 (rank : 1724)	θ value	0.163984 (rank : 1208)
Query Neighborhood Hits	1931	Target Neighborhood Hits	161	Shared Neighborhood Hits	50
SwissProt Accessions	Q13202	Gene names	DUSP8, VH5
Domain Architecture
Description	Dual specificity protein phosphatase 8 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase hVH-5).

NEB2_HUMAN
NC score	0.007977 (rank : 1725)	θ value	6.88961 (rank : 1791)
Query Neighborhood Hits	1931	Target Neighborhood Hits	883	Shared Neighborhood Hits	95
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

STABP_MOUSE
NC score	0.007976 (rank : 1726)	θ value	1.81305 (rank : 1513)
Query Neighborhood Hits	1931	Target Neighborhood Hits	191	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CQ26, Q3UTI9	Gene names	Stambp, Amsh
Domain Architecture	No domain graphic available
Description	STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3 domain of STAM).

COAA1_HUMAN
NC score	0.007915 (rank : 1727)	θ value	0.163984 (rank : 1205)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	118
SwissProt Accessions	Q03692	Gene names	COL10A1
Domain Architecture
Description	Collagen alpha-1(X) chain precursor.

SPT12_HUMAN
NC score	0.007901 (rank : 1728)	θ value	4.03905 (rank : 1684)
Query Neighborhood Hits	1931	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z6I5	Gene names	SPATA12, SRG5
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 12 (Spermatogenesis-related protein 5).

EMID2_MOUSE
NC score	0.007890 (rank : 1729)	θ value	8.99809 (rank : 1847)
Query Neighborhood Hits	1931	Target Neighborhood Hits	201	Shared Neighborhood Hits	78
SwissProt Accessions	Q91VF6, Q8K4P3	Gene names	Emid2, Col26a, Col26a1, Emu2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XXVI) chain precursor (EMI domain-containing protein 2) (Protein Emu2) (Emilin and multimerin domain-containing protein 2).

SRCA_HUMAN
NC score	0.007815 (rank : 1730)	θ value	1.38821 (rank : 1470)
Query Neighborhood Hits	1931	Target Neighborhood Hits	380	Shared Neighborhood Hits	75
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

NUMB_MOUSE
NC score	0.007769 (rank : 1731)	θ value	1.81305 (rank : 1505)
Query Neighborhood Hits	1931	Target Neighborhood Hits	91	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZS3, P70422, Q8CIB1, Q9DC57, Q9QZR1, Q9QZS4	Gene names	Numb
Domain Architecture
Description	Protein numb homolog (m-Numb) (m-Nb).

MORC3_HUMAN
NC score	0.007746 (rank : 1732)	θ value	0.813845 (rank : 1383)
Query Neighborhood Hits	1931	Target Neighborhood Hits	489	Shared Neighborhood Hits	44
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

DACH1_HUMAN
NC score	0.007734 (rank : 1733)	θ value	0.813845 (rank : 1370)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

HPLN1_MOUSE
NC score	0.007696 (rank : 1734)	θ value	4.03905 (rank : 1656)
Query Neighborhood Hits	1931	Target Neighborhood Hits	64	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QUP5, Q9D1G9, Q9Z1X7	Gene names	Hapln1, Crtl1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 1 precursor (Proteoglycan link protein) (Cartilage link protein) (LP).

SYNP2_MOUSE
NC score	0.007596 (rank : 1735)	θ value	8.99809 (rank : 1913)
Query Neighborhood Hits	1931	Target Neighborhood Hits	252	Shared Neighborhood Hits	65
SwissProt Accessions	Q91YE8, Q8C592	Gene names	Synpo2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin).

CF141_HUMAN
NC score	0.007539 (rank : 1736)	θ value	4.03905 (rank : 1632)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SZD1, Q8N400, Q96NQ1	Gene names	C6orf141
Domain Architecture	No domain graphic available
Description	Protein C6orf141.

CNGB1_HUMAN
NC score	0.007445 (rank : 1737)	θ value	5.27518 (rank : 1705)
Query Neighborhood Hits	1931	Target Neighborhood Hits	222	Shared Neighborhood Hits	42
SwissProt Accessions	Q14028, Q14029	Gene names	CNGB1, CNCG4
Domain Architecture
Description	Cyclic nucleotide-gated cation channel 4 (CNG channel 4) (CNG-4) (CNG4) (Cyclic nucleotide-gated cation channel modulatory subunit).

CO8A2_HUMAN
NC score	0.007425 (rank : 1738)	θ value	4.03905 (rank : 1638)
Query Neighborhood Hits	1931	Target Neighborhood Hits	299	Shared Neighborhood Hits	107
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

DIAP2_MOUSE
NC score	0.007420 (rank : 1739)	θ value	4.03905 (rank : 1644)
Query Neighborhood Hits	1931	Target Neighborhood Hits	260	Shared Neighborhood Hits	65
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

PA24A_MOUSE
NC score	0.007387 (rank : 1740)	θ value	5.27518 (rank : 1732)
Query Neighborhood Hits	1931	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	P47713	Gene names	Pla2g4a, Cpla2, Pla2g4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

ZCH11_HUMAN
NC score	0.007331 (rank : 1741)	θ value	5.27518 (rank : 1742)
Query Neighborhood Hits	1931	Target Neighborhood Hits	278	Shared Neighborhood Hits	54
SwissProt Accessions	Q5TAX3, Q12764, Q5TAX4, Q86XZ3	Gene names	ZCCHC11, KIAA0191
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 11.

CO4A6_HUMAN
NC score	0.007316 (rank : 1742)	θ value	2.36792 (rank : 1534)
Query Neighborhood Hits	1931	Target Neighborhood Hits	318	Shared Neighborhood Hits	105
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

TOPB1_MOUSE
NC score	0.007253 (rank : 1743)	θ value	0.813845 (rank : 1392)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	Q6ZQF0, Q6P6P0, Q80Y33, Q8BUI0, Q8BUK1, Q8R348, Q91VX3, Q922X8	Gene names	Topbp1, Kiaa0259
Domain Architecture	No domain graphic available
Description	DNA topoisomerase II-binding protein 1 (DNA topoisomerase IIbeta- binding protein 1) (TopBP1).

RSSA_MOUSE
NC score	0.007232 (rank : 1744)	θ value	3.0926 (rank : 1616)
Query Neighborhood Hits	1931	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P14206	Gene names	Rpsa, Lamr1, P40-8
Domain Architecture
Description	40S ribosomal protein SA (p40) (34/67 kDa laminin receptor).

RSSA_HUMAN
NC score	0.007229 (rank : 1745)	θ value	3.0926 (rank : 1615)
Query Neighborhood Hits	1931	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	P08865, P11085, P12030, Q16471, Q6IPD1	Gene names	RPSA, LAMBR, LAMR1
Domain Architecture
Description	40S ribosomal protein SA (p40) (34/67 kDa laminin receptor) (Colon carcinoma laminin-binding protein) (NEM/1CHD4) (Multidrug resistance- associated protein MGr1-Ag).

CA106_MOUSE
NC score	0.007222 (rank : 1746)	θ value	4.03905 (rank : 1627)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	34
SwissProt Accessions	Q7TN12, Q7TN27, Q8BGK3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106 homolog.

PA24A_HUMAN
NC score	0.007214 (rank : 1747)	θ value	6.88961 (rank : 1796)
Query Neighborhood Hits	1931	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	P47712	Gene names	PLA2G4A, CPLA2, PLA2G4
Domain Architecture
Description	Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2- acylhydrolase); Lysophospholipase (EC 3.1.1.5)].

AFF3_HUMAN
NC score	0.007184 (rank : 1748)	θ value	6.88961 (rank : 1750)
Query Neighborhood Hits	1931	Target Neighborhood Hits	190	Shared Neighborhood Hits	51
SwissProt Accessions	P51826	Gene names	AFF3, LAF4
Domain Architecture
Description	AF4/FMR2 family member 3 (Protein LAF-4) (Lymphoid nuclear protein related to AF4).

IQEC3_MOUSE
NC score	0.007069 (rank : 1749)	θ value	8.99809 (rank : 1867)
Query Neighborhood Hits	1931	Target Neighborhood Hits	274	Shared Neighborhood Hits	93
SwissProt Accessions	Q3TES0, Q3UHP8, Q80TJ8	Gene names	Iqsec3, Kiaa1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

MGMT_MOUSE
NC score	0.006981 (rank : 1750)	θ value	2.36792 (rank : 1554)
Query Neighborhood Hits	1931	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P26187, Q54A49	Gene names	Mgmt
Domain Architecture
Description	Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O- methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA- alkyltransferase).

SMCA2_HUMAN
NC score	0.006912 (rank : 1751)	θ value	0.163984 (rank : 1224)
Query Neighborhood Hits	1931	Target Neighborhood Hits	503	Shared Neighborhood Hits	106
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

CHD9_MOUSE
NC score	0.006843 (rank : 1752)	θ value	0.813845 (rank : 1366)
Query Neighborhood Hits	1931	Target Neighborhood Hits	427	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

KI2L4_HUMAN
NC score	0.006787 (rank : 1753)	θ value	4.03905 (rank : 1662)
Query Neighborhood Hits	1931	Target Neighborhood Hits	68	Shared Neighborhood Hits	29
SwissProt Accessions	Q99706, O14621, O14622, O14623, O14624, O43534, P78400, P78401, Q99559, Q99560, Q99561, Q99562, Q9UQJ7	Gene names	KIR2DL4, CD158D, KIR103AS
Domain Architecture
Description	Killer cell immunoglobulin-like receptor 2DL4 precursor (MHC class I NK cell receptor KIR103AS) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (G9P) (CD158d antigen).

TM16H_HUMAN
NC score	0.006775 (rank : 1754)	θ value	8.99809 (rank : 1918)
Query Neighborhood Hits	1931	Target Neighborhood Hits	139	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HCE9	Gene names	TMEM16H, KIAA1623
Domain Architecture	No domain graphic available
Description	Transmembrane protein 16H.

COBA1_HUMAN
NC score	0.006718 (rank : 1755)	θ value	8.99809 (rank : 1839)
Query Neighborhood Hits	1931	Target Neighborhood Hits	491	Shared Neighborhood Hits	143
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

ASPM_MOUSE
NC score	0.006698 (rank : 1756)	θ value	4.03905 (rank : 1625)
Query Neighborhood Hits	1931	Target Neighborhood Hits	150	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CJ27, O88482, Q8BJI8, Q8BKT4	Gene names	Aspm, Calmbp1, Sha1
Domain Architecture
Description	Abnormal spindle-like microcephaly-associated protein homolog (Calmodulin-binding protein 1) (Spindle and hydroxyurea checkpoint abnormal protein) (Calmodulin-binding protein Sha1).

DOCK4_HUMAN
NC score	0.006607 (rank : 1757)	θ value	4.03905 (rank : 1645)
Query Neighborhood Hits	1931	Target Neighborhood Hits	237	Shared Neighborhood Hits	89
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

BTNL3_HUMAN
NC score	0.006549 (rank : 1758)	θ value	8.99809 (rank : 1831)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	53
SwissProt Accessions	Q6UXE8, Q9Y2C7	Gene names	BTNL3, BTNLR, COLF4100
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 3 precursor (Butyrophilin-like receptor).

GC3M_MOUSE
NC score	0.006528 (rank : 1759)	θ value	8.99809 (rank : 1855)
Query Neighborhood Hits	1931	Target Neighborhood Hits	215	Shared Neighborhood Hits	44
SwissProt Accessions	P03987	Gene names
Domain Architecture
Description	Ig gamma-3 chain C region, membrane-bound form.

CTND2_MOUSE
NC score	0.006483 (rank : 1760)	θ value	2.36792 (rank : 1539)
Query Neighborhood Hits	1931	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	O35927	Gene names	Ctnnd2, Catnd2, Nprap
Domain Architecture
Description	Catenin delta-2 (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin).

NUP53_MOUSE
NC score	0.006411 (rank : 1761)	θ value	8.99809 (rank : 1886)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4R6, Q9D7J2	Gene names	Nup35, Mp44, Nup53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

NFAC3_MOUSE
NC score	0.006381 (rank : 1762)	θ value	1.38821 (rank : 1460)
Query Neighborhood Hits	1931	Target Neighborhood Hits	106	Shared Neighborhood Hits	29
SwissProt Accessions	P97305, Q60896	Gene names	Nfatc3, Nfat4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

CB024_MOUSE
NC score	0.006323 (rank : 1763)	θ value	1.81305 (rank : 1485)
Query Neighborhood Hits	1931	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K158, Q3TE87	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf24 homolog.

FA48A_HUMAN
NC score	0.006312 (rank : 1764)	θ value	4.03905 (rank : 1649)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NEM7, Q71RF3, Q9Y6A6	Gene names	FAM48A
Domain Architecture	No domain graphic available
Description	Protein FAM48A (p38-interacting protein) (p38IP).

GC3_MOUSE
NC score	0.006267 (rank : 1765)	θ value	8.99809 (rank : 1856)
Query Neighborhood Hits	1931	Target Neighborhood Hits	212	Shared Neighborhood Hits	43
SwissProt Accessions	P22436	Gene names
Domain Architecture	No domain graphic available
Description	Ig gamma-3 chain C region, secreted form.

DTNA_MOUSE
NC score	0.006260 (rank : 1766)	θ value	1.81305 (rank : 1491)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	35
SwissProt Accessions	Q9D2N4, P97319, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0	Gene names	Dtna, Dtn
Domain Architecture
Description	Dystrobrevin alpha (Alpha-dystrobrevin).

PAX1_HUMAN
NC score	0.006198 (rank : 1767)	θ value	0.279714 (rank : 1255)
Query Neighborhood Hits	1931	Target Neighborhood Hits	72	Shared Neighborhood Hits	22
SwissProt Accessions	P15863, Q642X9, Q6NTC0, Q9Y558	Gene names	PAX1, HUP48
Domain Architecture
Description	Paired box protein Pax-1 (HUP48).

TRML2_MOUSE
NC score	0.006177 (rank : 1768)	θ value	8.99809 (rank : 1922)
Query Neighborhood Hits	1931	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q2LA85	Gene names	Treml2, Tlt2
Domain Architecture	No domain graphic available
Description	Trem-like transcript 2 protein precursor (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2).

ELL_MOUSE
NC score	0.006113 (rank : 1769)	θ value	1.38821 (rank : 1448)
Query Neighborhood Hits	1931	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	O08856	Gene names	Ell
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

CO9A2_MOUSE
NC score	0.006100 (rank : 1770)	θ value	5.27518 (rank : 1706)
Query Neighborhood Hits	1931	Target Neighborhood Hits	279	Shared Neighborhood Hits	98
SwissProt Accessions	Q07643	Gene names	Col9a2
Domain Architecture	No domain graphic available
Description	Collagen alpha-2(IX) chain precursor.

NUDC3_HUMAN
NC score	0.005990 (rank : 1771)	θ value	1.81305 (rank : 1504)
Query Neighborhood Hits	1931	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IVD9, Q9BTI3, Q9H7W9, Q9UPT4	Gene names	NUDCD3, KIAA1068
Domain Architecture	No domain graphic available
Description	NudC domain-containing protein 3.

COJA1_HUMAN
NC score	0.005810 (rank : 1772)	θ value	2.36792 (rank : 1537)
Query Neighborhood Hits	1931	Target Neighborhood Hits	323	Shared Neighborhood Hits	105
SwissProt Accessions	Q14993, Q00559, Q05850, Q12885, Q13676, Q5JUF0, Q5T424, Q9H572, Q9NPZ2, Q9NQP2	Gene names	COL19A1
Domain Architecture
Description	Collagen alpha-1(XIX) chain precursor (Collagen alpha-1(Y) chain).

NFAC1_MOUSE
NC score	0.005771 (rank : 1773)	θ value	3.0926 (rank : 1608)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	O88942, O70345	Gene names	Nfatc1, Nfat2, Nfatc
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

AF17_HUMAN
NC score	0.005709 (rank : 1774)	θ value	8.99809 (rank : 1821)
Query Neighborhood Hits	1931	Target Neighborhood Hits	230	Shared Neighborhood Hits	62
SwissProt Accessions	P55198, Q9UF49	Gene names	MLLT6, AF17
Domain Architecture
Description	Protein AF-17.

CUTL1_HUMAN
NC score	0.005687 (rank : 1775)	θ value	6.88961 (rank : 1767)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1574	Shared Neighborhood Hits	191
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

DTNA_HUMAN
NC score	0.005646 (rank : 1776)	θ value	5.27518 (rank : 1710)
Query Neighborhood Hits	1931	Target Neighborhood Hits	295	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y4J8, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500	Gene names	DTNA, DRP3
Domain Architecture
Description	Dystrobrevin alpha (Dystrobrevin-alpha) (Dystrophin-related protein 3).

RGP2_HUMAN
NC score	0.005547 (rank : 1777)	θ value	0.813845 (rank : 1390)
Query Neighborhood Hits	1931	Target Neighborhood Hits	60	Shared Neighborhood Hits	19
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

EP15R_MOUSE
NC score	0.005496 (rank : 1778)	θ value	8.99809 (rank : 1848)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1135	Shared Neighborhood Hits	113
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

DOCK4_MOUSE
NC score	0.005431 (rank : 1779)	θ value	4.03905 (rank : 1646)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	80
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

UBE4B_HUMAN
NC score	0.005333 (rank : 1780)	θ value	6.88961 (rank : 1809)
Query Neighborhood Hits	1931	Target Neighborhood Hits	158	Shared Neighborhood Hits	47
SwissProt Accessions	O95155, O75169, O95338, Q5SZ12, Q5SZ16, Q96QD4, Q9BYI7	Gene names	UBE4B, HDNB1, KIAA0684, UFD2
Domain Architecture
Description	Ubiquitin conjugation factor E4 B (Ubiquitin fusion degradation protein 2) (Homozygously deleted in neuroblastoma 1).

LBXCO_MOUSE
NC score	0.005188 (rank : 1781)	θ value	6.88961 (rank : 1788)
Query Neighborhood Hits	1931	Target Neighborhood Hits	140	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

SMRC2_MOUSE
NC score	0.005106 (rank : 1782)	θ value	4.03905 (rank : 1682)
Query Neighborhood Hits	1931	Target Neighborhood Hits	487	Shared Neighborhood Hits	99
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

CF051_HUMAN
NC score	0.004990 (rank : 1783)	θ value	8.99809 (rank : 1836)
Query Neighborhood Hits	1931	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q969F1	Gene names	C6orf51
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf51.

BPAEA_HUMAN
NC score	0.004968 (rank : 1784)	θ value	8.99809 (rank : 1827)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1369	Shared Neighborhood Hits	103
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BAZ1B_HUMAN
NC score	0.004864 (rank : 1785)	θ value	8.99809 (rank : 1824)
Query Neighborhood Hits	1931	Target Neighborhood Hits	701	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

LDB3_HUMAN
NC score	0.004791 (rank : 1786)	θ value	5.27518 (rank : 1723)
Query Neighborhood Hits	1931	Target Neighborhood Hits	497	Shared Neighborhood Hits	112
SwissProt Accessions	O75112, Q5K6N9, Q5K6P0, Q5K6P1, Q96FH2, Q9Y4Z3, Q9Y4Z4, Q9Y4Z5	Gene names	LDB3, KIAA0613, ZASP
Domain Architecture	No domain graphic available
Description	LIM domain-binding protein 3 (Z-band alternatively spliced PDZ-motif protein) (Protein cypher).

CLIC6_MOUSE
NC score	0.004763 (rank : 1787)	θ value	1.81305 (rank : 1487)
Query Neighborhood Hits	1931	Target Neighborhood Hits	134	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BHB9	Gene names	Clic6
Domain Architecture	No domain graphic available
Description	Chloride intracellular channel 6.

OGG1_MOUSE
NC score	0.004720 (rank : 1788)	θ value	3.0926 (rank : 1609)
Query Neighborhood Hits	1931	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	O08760, O08733, O08910, O08991, O35617, O35915, Q9QXE8	Gene names	Ogg1
Domain Architecture
Description	N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase (EC 3.2.2.-); DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) (AP lyase)].

FBX42_HUMAN
NC score	0.004691 (rank : 1789)	θ value	1.81305 (rank : 1493)
Query Neighborhood Hits	1931	Target Neighborhood Hits	121	Shared Neighborhood Hits	25
SwissProt Accessions	Q6P3S6, Q5TEU8, Q86XI0, Q8N3N4, Q8N5F8, Q9BRM0, Q9P2L4	Gene names	FBXO42, FBX42, KIAA1332
Domain Architecture	No domain graphic available
Description	F-box only protein 42.

ZYX_HUMAN
NC score	0.004690 (rank : 1790)	θ value	8.99809 (rank : 1931)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	85
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

S2A4R_HUMAN
NC score	0.004656 (rank : 1791)	θ value	8.99809 (rank : 1900)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NR83, Q6F6I6, Q6F6I7, Q6GTK5, Q8TAH5, Q8WVW7, Q96QD3, Q9BV85	Gene names	SLC2A4RG, HDBP1
Domain Architecture	No domain graphic available
Description	SLC2A4 regulator (GLUT4 enhancer factor) (GEF) (Huntington disease gene regulatory region-binding protein 1) (HDBP-1).

TVC_HUMAN
NC score	0.004629 (rank : 1792)	θ value	1.38821 (rank : 1474)
Query Neighborhood Hits	1931	Target Neighborhood Hits	179	Shared Neighborhood Hits	48
SwissProt Accessions	P03979	Gene names	TCRB
Domain Architecture
Description	T-cell receptor gamma chain V region PT-gamma-1/2 precursor.

TDIF1_HUMAN
NC score	0.004593 (rank : 1793)	θ value	4.03905 (rank : 1687)
Query Neighborhood Hits	1931	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H147, Q96DE3, Q9BQP2, Q9H148	Gene names	DNTTIP1, C20orf167, TDIF1
Domain Architecture	No domain graphic available
Description	Terminal deoxynucleotidyltransferase-interacting factor 1 (TdT- interacting factor 1) (TdIF1).

NOTC2_HUMAN
NC score	0.004533 (rank : 1794)	θ value	2.36792 (rank : 1560)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1113	Shared Neighborhood Hits	186
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NCOA3_MOUSE
NC score	0.004470 (rank : 1795)	θ value	0.47712 (rank : 1310)
Query Neighborhood Hits	1931	Target Neighborhood Hits	203	Shared Neighborhood Hits	56
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

SPTN2_HUMAN
NC score	0.004308 (rank : 1796)	θ value	0.62314 (rank : 1353)
Query Neighborhood Hits	1931	Target Neighborhood Hits	535	Shared Neighborhood Hits	76
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

GAB2_HUMAN
NC score	0.004217 (rank : 1797)	θ value	4.03905 (rank : 1651)
Query Neighborhood Hits	1931	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

LV5A_HUMAN
NC score	0.004168 (rank : 1798)	θ value	6.88961 (rank : 1789)
Query Neighborhood Hits	1931	Target Neighborhood Hits	220	Shared Neighborhood Hits	70
SwissProt Accessions	P01719	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-V region DEL.

KI3L2_HUMAN
NC score	0.004135 (rank : 1799)	θ value	2.36792 (rank : 1550)
Query Neighborhood Hits	1931	Target Neighborhood Hits	58	Shared Neighborhood Hits	23
SwissProt Accessions	P43630, Q13238, Q14947, Q14948, Q92684, Q95367	Gene names	KIR3DL2, CD158K, NKAT4
Domain Architecture	No domain graphic available
Description	Killer cell immunoglobulin-like receptor 3DL2 precursor (MHC class I NK cell receptor) (Natural killer-associated transcript 4) (NKAT-4) (p70 natural killer cell receptor clone CL-5) (CD158k antigen).

THAP8_HUMAN
NC score	0.004111 (rank : 1800)	θ value	8.99809 (rank : 1917)
Query Neighborhood Hits	1931	Target Neighborhood Hits	35	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NA92, Q96M21	Gene names	THAP8
Domain Architecture
Description	THAP domain-containing protein 8.

SMBP2_MOUSE
NC score	0.004024 (rank : 1801)	θ value	1.38821 (rank : 1469)
Query Neighborhood Hits	1931	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

SOX9_HUMAN
NC score	0.004012 (rank : 1802)	θ value	0.0736092 (rank : 1156)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	56
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

RB_MOUSE
NC score	0.004007 (rank : 1803)	θ value	2.36792 (rank : 1565)
Query Neighborhood Hits	1931	Target Neighborhood Hits	31	Shared Neighborhood Hits	10
SwissProt Accessions	P13405	Gene names	Rb1, Rb-1
Domain Architecture
Description	Retinoblastoma-associated protein (PP105) (RB).

LPIN3_HUMAN
NC score	0.003953 (rank : 1804)	θ value	3.0926 (rank : 1602)
Query Neighborhood Hits	1931	Target Neighborhood Hits	92	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

NEIL1_MOUSE
NC score	0.003924 (rank : 1805)	θ value	4.03905 (rank : 1669)
Query Neighborhood Hits	1931	Target Neighborhood Hits	52	Shared Neighborhood Hits	11
SwissProt Accessions	Q8K4Q6, Q80V58, Q9CYT9	Gene names	Neil1, Nei1
Domain Architecture	No domain graphic available
Description	Endonuclease VIII-like 1 (EC 3.2.2.-) (EC 4.2.99.18) (Nei-like 1) (DNA glycosylase/AP lyase Neil1) (DNA-(apurinic or apyrimidinic site) lyase Neil1) (NEH1).

GP123_HUMAN
NC score	0.003799 (rank : 1806)	θ value	5.27518 (rank : 1713)
Query Neighborhood Hits	1931	Target Neighborhood Hits	120	Shared Neighborhood Hits	33
SwissProt Accessions	Q86SQ6, Q86SN7, Q96JJ9	Gene names	GPR123, KIAA1828
Domain Architecture
Description	Probable G-protein coupled receptor 123.

CP053_HUMAN
NC score	0.003773 (rank : 1807)	θ value	8.99809 (rank : 1841)
Query Neighborhood Hits	1931	Target Neighborhood Hits	45	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BTK6	Gene names	C16orf53
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf53.

PDLI4_HUMAN
NC score	0.003719 (rank : 1808)	θ value	0.62314 (rank : 1343)
Query Neighborhood Hits	1931	Target Neighborhood Hits	245	Shared Neighborhood Hits	34
SwissProt Accessions	P50479, Q96AT8, Q9BTW8, Q9Y292	Gene names	PDLIM4, RIL
Domain Architecture
Description	PDZ and LIM domain protein 4 (LIM protein RIL) (Reversion-induced LIM protein).

CENPT_HUMAN
NC score	0.003683 (rank : 1809)	θ value	6.88961 (rank : 1761)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	14
SwissProt Accessions	Q96BT3, Q96I29, Q96IC6, Q96NK9, Q9H901	Gene names	CENPT, C16orf56, ICEN22
Domain Architecture	No domain graphic available
Description	Centromere protein T (CENP-T) (Interphase centromere complex protein 22).

SOX9_MOUSE
NC score	0.003673 (rank : 1810)	θ value	0.00665767 (rank : 1045)
Query Neighborhood Hits	1931	Target Neighborhood Hits	188	Shared Neighborhood Hits	41
SwissProt Accessions	Q04887, Q8C7L2, Q91ZK2, Q99KQ0	Gene names	Sox9, Sox-9
Domain Architecture
Description	Transcription factor SOX-9.

IRX5_HUMAN
NC score	0.003655 (rank : 1811)	θ value	0.813845 (rank : 1378)
Query Neighborhood Hits	1931	Target Neighborhood Hits	362	Shared Neighborhood Hits	74
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

NOTC3_HUMAN
NC score	0.003480 (rank : 1812)	θ value	0.21417 (rank : 1237)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1062	Shared Neighborhood Hits	150
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

2B1A_HUMAN
NC score	0.003327 (rank : 1813)	θ value	1.38821 (rank : 1434)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	42
SwissProt Accessions	Q30167, Q9MYF5	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-10 beta chain precursor (MHC class I antigen DRB1*10) (DRw10).

EMIL1_HUMAN
NC score	0.003305 (rank : 1814)	θ value	3.0926 (rank : 1588)
Query Neighborhood Hits	1931	Target Neighborhood Hits	239	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y6C2, Q96G58, Q9UG76	Gene names	EMILIN1, EMI
Domain Architecture
Description	EMILIN-1 precursor (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1).

LV3B_HUMAN
NC score	0.003262 (rank : 1815)	θ value	3.0926 (rank : 1606)
Query Neighborhood Hits	1931	Target Neighborhood Hits	232	Shared Neighborhood Hits	73
SwissProt Accessions	P80748	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-III region LOI.

CDS2_HUMAN
NC score	0.003247 (rank : 1816)	θ value	1.38821 (rank : 1437)
Query Neighborhood Hits	1931	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	O95674, Q5TDY2, Q5TDY3, Q5TDY4, Q5TDY5, Q9BYK5, Q9NTT2	Gene names	CDS2
Domain Architecture
Description	Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-diglyceride synthetase 2) (CDP-diglyceride pyrophosphorylase 2) (CDP- diacylglycerol synthase 2) (CDS 2) (CTP:phosphatidate cytidylyltransferase 2) (CDP-DAG synthase 2) (CDP-DG synthetase 2).

MSRB2_HUMAN
NC score	0.003192 (rank : 1817)	θ value	8.99809 (rank : 1881)
Query Neighborhood Hits	1931	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3D2, Q9Y5W6	Gene names	MSRB2, MSRB
Domain Architecture
Description	Methionine-R-sulfoxide reductase B2 (EC 1.8.4.-).

NOTC2_MOUSE
NC score	0.003153 (rank : 1818)	θ value	8.99809 (rank : 1885)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1069	Shared Neighborhood Hits	151
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

CEBPA_HUMAN
NC score	0.003084 (rank : 1819)	θ value	1.38821 (rank : 1438)
Query Neighborhood Hits	1931	Target Neighborhood Hits	99	Shared Neighborhood Hits	14
SwissProt Accessions	P49715, P78319	Gene names	CEBPA
Domain Architecture
Description	CCAAT/enhancer-binding protein alpha (C/EBP alpha).

ATF6B_MOUSE
NC score	0.003080 (rank : 1820)	θ value	5.27518 (rank : 1700)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	24
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

PTDSR_HUMAN
NC score	0.003015 (rank : 1821)	θ value	4.03905 (rank : 1675)
Query Neighborhood Hits	1931	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q6NYC1, Q86VY0, Q8IUM5, Q9Y4E2	Gene names	PTDSR, KIAA0585
Domain Architecture	No domain graphic available
Description	Protein PTDSR (Phosphatidylserine receptor).

CUED1_MOUSE
NC score	0.002994 (rank : 1822)	θ value	5.27518 (rank : 1707)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R3V6	Gene names	Cuedc1
Domain Architecture
Description	CUE domain-containing protein 1.

NFAC3_HUMAN
NC score	0.002990 (rank : 1823)	θ value	6.88961 (rank : 1794)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	25
SwissProt Accessions	Q12968, O75211, Q14516, Q99840, Q99841, Q99842	Gene names	NFATC3, NFAT4
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (T cell transcription factor NFAT4) (NF-AT4) (NFATx).

SRA1_MOUSE
NC score	0.002913 (rank : 1824)	θ value	8.99809 (rank : 1909)
Query Neighborhood Hits	1931	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q80VJ2, Q8R0S3, Q9CWU7, Q9D973	Gene names	Sra1
Domain Architecture	No domain graphic available
Description	Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP).

CP007_HUMAN
NC score	0.002890 (rank : 1825)	θ value	8.99809 (rank : 1840)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y2B5	Gene names	C16orf7, ATPBL
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C16orf7 (Protein ATP-BL).

TFF2_HUMAN
NC score	0.002832 (rank : 1826)	θ value	4.03905 (rank : 1688)
Query Neighborhood Hits	1931	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q03403, Q15854	Gene names	TFF2, SML1
Domain Architecture
Description	Trefoil factor 2 precursor (Spasmolytic polypeptide) (SP) (Spasmolysin).

SP17_HUMAN
NC score	0.002824 (rank : 1827)	θ value	8.99809 (rank : 1908)
Query Neighborhood Hits	1931	Target Neighborhood Hits	34	Shared Neighborhood Hits	7
SwissProt Accessions	Q15506, Q9BXF7	Gene names	SPA17, SP17
Domain Architecture
Description	Sperm surface protein Sp17 (Sperm autoantigenic protein 17) (Sperm protein 17) (Sp17-1).

HB2C_HUMAN
NC score	0.002732 (rank : 1828)	θ value	1.38821 (rank : 1452)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	41
SwissProt Accessions	P01914	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DR-1 beta chain precursor (Clone P2-beta-4).

SFR14_MOUSE
NC score	0.002718 (rank : 1829)	θ value	5.27518 (rank : 1738)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

KCNN1_HUMAN
NC score	0.002693 (rank : 1830)	θ value	1.06291 (rank : 1409)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	17
SwissProt Accessions	Q92952	Gene names	KCNN1, SK
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 1 (SK1).

TM55B_MOUSE
NC score	0.002677 (rank : 1831)	θ value	6.88961 (rank : 1806)
Query Neighborhood Hits	1931	Target Neighborhood Hits	50	Shared Neighborhood Hits	20
SwissProt Accessions	Q3TWL2	Gene names	Tmem55b
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55B (EC 3.1.3.-) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase I).

PER3_MOUSE
NC score	0.002668 (rank : 1832)	θ value	8.99809 (rank : 1890)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	18
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

AIPL1_HUMAN
NC score	0.002658 (rank : 1833)	θ value	0.813845 (rank : 1363)
Query Neighborhood Hits	1931	Target Neighborhood Hits	113	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZN9, Q9H873, Q9NS10	Gene names	AIPL1
Domain Architecture
Description	Aryl-hydrocarbon-interacting protein-like 1.

LTBP4_MOUSE
NC score	0.002645 (rank : 1834)	θ value	1.06291 (rank : 1412)
Query Neighborhood Hits	1931	Target Neighborhood Hits	607	Shared Neighborhood Hits	96
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

GCNL2_HUMAN
NC score	0.002622 (rank : 1835)	θ value	8.99809 (rank : 1857)
Query Neighborhood Hits	1931	Target Neighborhood Hits	159	Shared Neighborhood Hits	54
SwissProt Accessions	Q92830, Q9UCW1	Gene names	GCN5L2, GCN5, HGCN5
Domain Architecture
Description	General control of amino acid synthesis protein 5-like 2 (EC 2.3.1.48) (Histone acetyltransferase GCN5) (hsGCN5) (STAF97).

GGA2_HUMAN
NC score	0.002538 (rank : 1836)	θ value	4.03905 (rank : 1653)
Query Neighborhood Hits	1931	Target Neighborhood Hits	114	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UJY4, O14564, Q9NYN2, Q9UPS2	Gene names	GGA2, KIAA1080
Domain Architecture
Description	ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (Gamma-adaptin-related protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear).

DYN3_HUMAN
NC score	0.002531 (rank : 1837)	θ value	8.99809 (rank : 1845)
Query Neighborhood Hits	1931	Target Neighborhood Hits	158	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

HB2B_HUMAN
NC score	0.002431 (rank : 1838)	θ value	0.62314 (rank : 1335)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	41
SwissProt Accessions	P01912	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DR-1 beta chain precursor (Clone P2-beta-3).

DC1L2_HUMAN
NC score	0.002430 (rank : 1839)	θ value	5.27518 (rank : 1708)
Query Neighborhood Hits	1931	Target Neighborhood Hits	39	Shared Neighborhood Hits	13
SwissProt Accessions	O43237, Q8TAT3	Gene names	DYNC1LI2, DNCLI2, LIC2
Domain Architecture
Description	Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC53/55) (LIC-2).

CEP41_HUMAN
NC score	0.002413 (rank : 1840)	θ value	8.99809 (rank : 1835)
Query Neighborhood Hits	1931	Target Neighborhood Hits	42	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BYV8, Q7Z496, Q86TM1, Q8NFU8, Q9H6A3, Q9NPV3	Gene names	TSGA14, CEP41
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 41 kDa (Cep41 protein) (Testis-specific gene A14 protein).

2DMA_MOUSE
NC score	0.002400 (rank : 1841)	θ value	0.813845 (rank : 1359)
Query Neighborhood Hits	1931	Target Neighborhood Hits	89	Shared Neighborhood Hits	27
SwissProt Accessions	P28078	Gene names	H2-DMa, H2-Ma, Ma
Domain Architecture
Description	Class II histocompatibility antigen, M alpha chain precursor.

HAIR_MOUSE
NC score	0.002376 (rank : 1842)	θ value	5.27518 (rank : 1714)
Query Neighborhood Hits	1931	Target Neighborhood Hits	97	Shared Neighborhood Hits	27
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

KCNN3_MOUSE
NC score	0.002344 (rank : 1843)	θ value	0.47712 (rank : 1305)
Query Neighborhood Hits	1931	Target Neighborhood Hits	171	Shared Neighborhood Hits	20
SwissProt Accessions	P58391	Gene names	Kcnn3, Sk3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3).

B4GN3_HUMAN
NC score	0.002301 (rank : 1844)	θ value	8.99809 (rank : 1823)
Query Neighborhood Hits	1931	Target Neighborhood Hits	128	Shared Neighborhood Hits	43
SwissProt Accessions	Q6L9W6, Q6ZNC1, Q8N7T6	Gene names	B4GALNT3
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.244) (NGalNAc-T2) (Beta- 1,4-N-acetylgalactosaminyltransferase III) (Beta4GalNAc-T3) (Beta4GalNAcT3).

CAC1A_HUMAN
NC score	0.002299 (rank : 1845)	θ value	6.88961 (rank : 1758)
Query Neighborhood Hits	1931	Target Neighborhood Hits	387	Shared Neighborhood Hits	116
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

GNDS_MOUSE
NC score	0.002217 (rank : 1846)	θ value	8.99809 (rank : 1858)
Query Neighborhood Hits	1931	Target Neighborhood Hits	115	Shared Neighborhood Hits	31
SwissProt Accessions	Q03385	Gene names	Ralgds, Rgds
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

EMIL1_MOUSE
NC score	0.002190 (rank : 1847)	θ value	6.88961 (rank : 1769)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	56
SwissProt Accessions	Q99K41	Gene names	Emilin1
Domain Architecture
Description	EMILIN-1 precursor (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1).

IFI3_MOUSE
NC score	0.002175 (rank : 1848)	θ value	1.38821 (rank : 1454)
Query Neighborhood Hits	1931	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O35368	Gene names	Ifi203
Domain Architecture
Description	Interferon-activable protein 203 (Ifi-203) (Interferon-inducible protein p203).

MTG8R_MOUSE
NC score	0.002106 (rank : 1849)	θ value	5.27518 (rank : 1728)
Query Neighborhood Hits	1931	Target Neighborhood Hits	124	Shared Neighborhood Hits	22
SwissProt Accessions	O70374	Gene names	Cbfa2t2, Cbfa2t2h, Mtgr1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1).

TBCD3_HUMAN
NC score	0.002051 (rank : 1850)	θ value	1.38821 (rank : 1473)
Query Neighborhood Hits	1931	Target Neighborhood Hits	51	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IZP1, Q9H0B9, Q9UDD4	Gene names	TBC1D3, PRC17
Domain Architecture
Description	TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein).

E2F2_HUMAN
NC score	0.002050 (rank : 1851)	θ value	2.36792 (rank : 1541)
Query Neighborhood Hits	1931	Target Neighborhood Hits	76	Shared Neighborhood Hits	19
SwissProt Accessions	Q14209	Gene names	E2F2
Domain Architecture
Description	Transcription factor E2F2 (E2F-2).

2B31_HUMAN
NC score	0.002043 (rank : 1852)	θ value	0.62314 (rank : 1326)
Query Neighborhood Hits	1931	Target Neighborhood Hits	207	Shared Neighborhood Hits	38
SwissProt Accessions	P79483, Q95359, Q96H16	Gene names	HLA-DRB3
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB3-1 beta chain precursor (MHC class I antigen DRB3*1).

EMIL3_HUMAN
NC score	0.001970 (rank : 1853)	θ value	4.03905 (rank : 1647)
Query Neighborhood Hits	1931	Target Neighborhood Hits	249	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NT22, Q76KT4	Gene names	EMILIN3, C20orf130, EMILIN5
Domain Architecture	No domain graphic available
Description	EMILIN-3 precursor (EMILIN-5) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5).

2B32_HUMAN
NC score	0.001923 (rank : 1854)	θ value	0.365318 (rank : 1264)
Query Neighborhood Hits	1931	Target Neighborhood Hits	207	Shared Neighborhood Hits	36
SwissProt Accessions	P01913, O78049, P79663, Q29721, Q29809, Q30144, Q9MYA4, Q9MYH3, Q9MYH4, Q9TPB5, Q9TQ21	Gene names	HLA-DRB3
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB3-2 beta chain precursor (MHC class I antigen DRB3*2).

MTG8R_HUMAN
NC score	0.001906 (rank : 1855)	θ value	4.03905 (rank : 1668)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	23
SwissProt Accessions	O43439, Q5TGE4, Q5TGE7, Q8IWF3, Q96B06, Q96L00, Q9H436, Q9UJP8, Q9UJP9, Q9UP24	Gene names	CBFA2T2, EHT, MTGR1
Domain Architecture
Description	Protein CBFA2T2 (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (ETO homologous on chromosome 20) (p85).

ZDHC8_HUMAN
NC score	0.001887 (rank : 1856)	θ value	6.88961 (rank : 1816)
Query Neighborhood Hits	1931	Target Neighborhood Hits	234	Shared Neighborhood Hits	95
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

SF3B4_HUMAN
NC score	0.001840 (rank : 1857)	θ value	0.47712 (rank : 1316)
Query Neighborhood Hits	1931	Target Neighborhood Hits	445	Shared Neighborhood Hits	101
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

CHD9_HUMAN
NC score	0.001827 (rank : 1858)	θ value	1.38821 (rank : 1439)
Query Neighborhood Hits	1931	Target Neighborhood Hits	343	Shared Neighborhood Hits	49
SwissProt Accessions	Q3L8U1, O15025, Q1WF12, Q6DTK9, Q9H9V7	Gene names	CHD9, KIAA0308, KISH2, PRIC320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin remodeling factor CHROM1) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha-interacting complex protein 320 kDa) (Kismet homolog 2).

PO210_MOUSE
NC score	0.001772 (rank : 1859)	θ value	8.99809 (rank : 1893)
Query Neighborhood Hits	1931	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QY81, Q3U031, Q69ZW2, Q7TQM1	Gene names	Nup210, Kiaa0906
Domain Architecture	No domain graphic available
Description	Nuclear pore membrane glycoprotein 210 precursor (POM210) (Nuclear pore protein gp210).

KCNH3_HUMAN
NC score	0.001724 (rank : 1860)	θ value	4.03905 (rank : 1661)
Query Neighborhood Hits	1931	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

LV4E_HUMAN
NC score	0.001724 (rank : 1861)	θ value	0.0431538 (rank : 1120)
Query Neighborhood Hits	1931	Target Neighborhood Hits	218	Shared Neighborhood Hits	58
SwissProt Accessions	P06889	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-IV region MOL.

RFTN1_MOUSE
NC score	0.001702 (rank : 1862)	θ value	6.88961 (rank : 1800)
Query Neighborhood Hits	1931	Target Neighborhood Hits	36	Shared Neighborhood Hits	9
SwissProt Accessions	Q6A0D4, Q3U654, Q3U8P6, Q80US1	Gene names	Rftn1, Kiaa0084
Domain Architecture	No domain graphic available
Description	Raftlin (Raft-linking protein).

ACOT8_MOUSE
NC score	0.001696 (rank : 1863)	θ value	8.99809 (rank : 1820)
Query Neighborhood Hits	1931	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P58137, Q8VHM4	Gene names	Acot8, Pte1, Pte2
Domain Architecture
Description	Acyl-coenzyme A thioesterase 8 (EC 3.1.2.2) (Acyl-CoA thioesterase 8) (Peroxisomal acyl-coenzyme A thioester hydrolase 1) (PTE-1) (Peroxisomal long-chain acyl-coA thioesterase 1) (Peroxisomal acyl-CoA thioesterase 2) (PTE-2).

2B1B_HUMAN
NC score	0.001693 (rank : 1864)	θ value	0.62314 (rank : 1325)
Query Neighborhood Hits	1931	Target Neighborhood Hits	208	Shared Neighborhood Hits	40
SwissProt Accessions	P20039, Q30006, Q9GIX8	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-11 beta chain precursor (MHC class I antigen DRB1*11) (DR-5) (DR5) (DRw11).

2B18_HUMAN
NC score	0.001573 (rank : 1865)	θ value	0.62314 (rank : 1324)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	38
SwissProt Accessions	Q30134, O19718, O19788, Q29968, Q30108, Q30115, Q9BCP0, Q9BCP1, Q9BCP2, Q9BD33, Q9TQ37, Q9UIM9	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-8 beta chain precursor (MHC class I antigen DRB1*8) (DR-8) (DR8) (DRw8).

LV3A_HUMAN
NC score	0.001525 (rank : 1866)	θ value	0.125558 (rank : 1191)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	P01714	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-III region SH.

2B11_HUMAN
NC score	0.001435 (rank : 1867)	θ value	0.62314 (rank : 1323)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	40
SwissProt Accessions	P04229, O62869, P13758, Q06662, Q30116, Q30117, Q95461, Q9BCL7, Q9GIK5, Q9MXZ0, Q9MXZ5, Q9TQ91	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-1 beta chain precursor (MHC class I antigen DRB1*1) (DR-1) (DR1).

ZDHC8_MOUSE
NC score	0.001422 (rank : 1868)	θ value	8.99809 (rank : 1925)
Query Neighborhood Hits	1931	Target Neighborhood Hits	243	Shared Neighborhood Hits	90
SwissProt Accessions	Q5Y5T5, Q7TNF7	Gene names	Zdhhc8
Domain Architecture	No domain graphic available
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8).

CACB3_MOUSE
NC score	0.001403 (rank : 1869)	θ value	8.99809 (rank : 1832)
Query Neighborhood Hits	1931	Target Neighborhood Hits	48	Shared Neighborhood Hits	8
SwissProt Accessions	P54285	Gene names	Cacnb3, Cacnlb3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit beta-3 (CAB3) (Calcium channel voltage-dependent subunit beta 3) (CCHB3).

ANXA7_HUMAN
NC score	0.001384 (rank : 1870)	θ value	4.03905 (rank : 1624)
Query Neighborhood Hits	1931	Target Neighborhood Hits	168	Shared Neighborhood Hits	56
SwissProt Accessions	P20073	Gene names	ANXA7, ANX7, SNX
Domain Architecture
Description	Annexin A7 (Annexin VII) (Synexin).

DEN2A_HUMAN
NC score	0.001383 (rank : 1871)	θ value	1.38821 (rank : 1446)
Query Neighborhood Hits	1931	Target Neighborhood Hits	83	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ULE3, Q1RMD5, Q86XY0	Gene names	DENND2A, KIAA1277
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 2A.

PPOX_MOUSE
NC score	0.001362 (rank : 1872)	θ value	8.99809 (rank : 1895)
Query Neighborhood Hits	1931	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	P51175, P97344, Q99M34	Gene names	Ppox
Domain Architecture
Description	Protoporphyrinogen oxidase (EC 1.3.3.4) (PPO).

S28A2_MOUSE
NC score	0.001341 (rank : 1873)	θ value	8.99809 (rank : 1899)
Query Neighborhood Hits	1931	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	O88627	Gene names	Slc28a2, Cnt2
Domain Architecture
Description	Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (Sodium/purine nucleoside cotransporter) (SPNT).

MSH4_HUMAN
NC score	0.001312 (rank : 1874)	θ value	2.36792 (rank : 1556)
Query Neighborhood Hits	1931	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	O15457, Q8NEB3, Q9UNP8	Gene names	MSH4
Domain Architecture
Description	MutS protein homolog 4.

2B19_HUMAN
NC score	0.001288 (rank : 1875)	θ value	1.06291 (rank : 1395)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	38
SwissProt Accessions	Q9TQE0, Q30149	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-9 beta chain precursor (MHC class I antigen DRB1*9) (DR-9) (DR9).

S28A2_HUMAN
NC score	0.001285 (rank : 1876)	θ value	8.99809 (rank : 1898)
Query Neighborhood Hits	1931	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	O43868, O43239	Gene names	SLC28A2, CNT2
Domain Architecture
Description	Sodium/nucleoside cotransporter 2 (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Sodium/purine nucleoside co- transporter) (SPNT).

HORN_HUMAN
NC score	0.001251 (rank : 1877)	θ value	8.99809 (rank : 1861)
Query Neighborhood Hits	1931	Target Neighborhood Hits	206	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YZ3	Gene names	HRNR, S100A18
Domain Architecture	No domain graphic available
Description	Hornerin.

PHF8_HUMAN
NC score	0.001241 (rank : 1878)	θ value	5.27518 (rank : 1733)
Query Neighborhood Hits	1931	Target Neighborhood Hits	105	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UPP1, Q5H9U5, Q5VUJ4, Q7Z6D4, Q9HAH2	Gene names	PHF8, KIAA1111, ZNF422
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

2B17_HUMAN
NC score	0.001200 (rank : 1879)	θ value	1.06291 (rank : 1394)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	39
SwissProt Accessions	P13761, O46699, O46872	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-7 beta chain precursor (MHC class I antigen DRB1*7) (DR-7) (DR7).

TM55B_HUMAN
NC score	0.001144 (rank : 1880)	θ value	8.99809 (rank : 1919)
Query Neighborhood Hits	1931	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	Q86T03, Q86U09, Q8WUC0, Q9BU67, Q9NSU8	Gene names	TMEM55B, C14orf9
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55B (EC 3.1.3.-) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase I).

CSTFT_MOUSE
NC score	0.001058 (rank : 1881)	θ value	0.279714 (rank : 1245)
Query Neighborhood Hits	1931	Target Neighborhood Hits	356	Shared Neighborhood Hits	70
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

2B14_HUMAN
NC score	0.000989 (rank : 1882)	θ value	1.81305 (rank : 1478)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	41
SwissProt Accessions	P13760, O19717, O19739, P13759, Q29875, Q30145, Q9GIX9, Q9GIY4, Q9MY13, Q9XRY5	Gene names	HLA-DRB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DRB1-4 beta chain precursor (MHC class I antigen DRB1*4) (DR-4) (DR4).

ANXA7_MOUSE
NC score	0.000928 (rank : 1883)	θ value	0.813845 (rank : 1364)
Query Neighborhood Hits	1931	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q07076	Gene names	Anxa7, Anx7
Domain Architecture
Description	Annexin A7 (Annexin VII) (Synexin).

APBB1_MOUSE
NC score	0.000920 (rank : 1884)	θ value	2.36792 (rank : 1522)
Query Neighborhood Hits	1931	Target Neighborhood Hits	75	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QXJ1, O08642, Q3TPU0, Q8BNF4, Q8BSR9	Gene names	Apbb1, Fe65
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family B member 1 (Fe65 protein).

G3BP_HUMAN
NC score	0.000908 (rank : 1885)	θ value	8.99809 (rank : 1854)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	34
SwissProt Accessions	Q13283	Gene names	G3BP, G3BP1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

ANX11_MOUSE
NC score	0.000897 (rank : 1886)	θ value	4.03905 (rank : 1623)
Query Neighborhood Hits	1931	Target Neighborhood Hits	200	Shared Neighborhood Hits	64
SwissProt Accessions	P97384	Gene names	Anxa11, Anx11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50).

LEG3_HUMAN
NC score	0.000855 (rank : 1887)	θ value	8.99809 (rank : 1875)
Query Neighborhood Hits	1931	Target Neighborhood Hits	124	Shared Neighborhood Hits	46
SwissProt Accessions	P17931, Q16005, Q96J47	Gene names	LGALS3, MAC2
Domain Architecture
Description	Galectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-binding protein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Laminin-binding protein) (Lectin L-29) (L-31) (Galactoside-binding protein) (GALBP).

CC019_HUMAN
NC score	0.000842 (rank : 1888)	θ value	8.99809 (rank : 1834)
Query Neighborhood Hits	1931	Target Neighborhood Hits	87	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PII3, Q96CS5	Gene names	C3orf19
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf19.

HB2K_HUMAN
NC score	0.000821 (rank : 1889)	θ value	1.06291 (rank : 1406)
Query Neighborhood Hits	1931	Target Neighborhood Hits	204	Shared Neighborhood Hits	35
SwissProt Accessions	P13762	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DR-W53 beta chain precursor.

MBD1_HUMAN
NC score	0.000646 (rank : 1890)	θ value	8.99809 (rank : 1879)
Query Neighborhood Hits	1931	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UIS9, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9	Gene names	MBD1, PCM1
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 1 (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1).

FXL13_HUMAN
NC score	0.000520 (rank : 1891)	θ value	6.88961 (rank : 1775)
Query Neighborhood Hits	1931	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NEE6, Q6UVW7, Q6UVW8, Q75MN5, Q86UJ5, Q8N7Y4, Q8TCL2, Q8WUF9, Q8WUG0	Gene names	FBXL13, FBL13
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein 13).

P53_HUMAN
NC score	0.000496 (rank : 1892)	θ value	6.88961 (rank : 1795)
Query Neighborhood Hits	1931	Target Neighborhood Hits	42	Shared Neighborhood Hits	13
SwissProt Accessions	P04637, Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61	Gene names	TP53, P53
Domain Architecture
Description	Cellular tumor antigen p53 (Tumor suppressor p53) (Phosphoprotein p53) (Antigen NY-CO-13).

ZN185_HUMAN
NC score	0.000434 (rank : 1893)	θ value	8.99809 (rank : 1928)
Query Neighborhood Hits	1931	Target Neighborhood Hits	112	Shared Neighborhood Hits	20
SwissProt Accessions	O15231, O00345, Q9NSD2	Gene names	ZNF185
Domain Architecture
Description	Zinc finger protein 185 (LIM-domain protein ZNF185) (P1-A).

AXN2_MOUSE
NC score	0.000399 (rank : 1894)	θ value	3.0926 (rank : 1577)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	28
SwissProt Accessions	O88566, Q9QXJ6	Gene names	Axin2
Domain Architecture
Description	Axin-2 (Axis inhibition protein 2) (Conductin) (Axin-like protein) (Axil).

KCNH3_MOUSE
NC score	0.000370 (rank : 1895)	θ value	5.27518 (rank : 1721)
Query Neighborhood Hits	1931	Target Neighborhood Hits	133	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

2DMB_HUMAN
NC score	0.000360 (rank : 1896)	θ value	8.99809 (rank : 1819)
Query Neighborhood Hits	1931	Target Neighborhood Hits	216	Shared Neighborhood Hits	46
SwissProt Accessions	P28068, O77936, Q13012, Q29751, Q9XRX2	Gene names	HLA-DMB, DMB, RING7
Domain Architecture
Description	HLA class II histocompatibility antigen, DM beta chain precursor (MHC class II antigen DMB).

TRAIP_MOUSE
NC score	0.000285 (rank : 1897)	θ value	8.99809 (rank : 1921)
Query Neighborhood Hits	1931	Target Neighborhood Hits	745	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

2DMB_MOUSE
NC score	0.000193 (rank : 1898)	θ value	6.88961 (rank : 1748)
Query Neighborhood Hits	1931	Target Neighborhood Hits	214	Shared Neighborhood Hits	44
SwissProt Accessions	P35737	Gene names	H2-DMb1, H-2Mb1, Mb
Domain Architecture
Description	Class II histocompatibility antigen, M beta 1 chain precursor (H2-M beta 1 chain).

TIF1G_MOUSE
NC score	0.000144 (rank : 1899)	θ value	2.36792 (rank : 1570)
Query Neighborhood Hits	1931	Target Neighborhood Hits	498	Shared Neighborhood Hits	103
SwissProt Accessions	Q99PP7, Q6SI71, Q6ZPX5	Gene names	Trim33, Kiaa1113
Domain Architecture	No domain graphic available
Description	Transcription intermediary factor 1-gamma (TIF1-gamma) (Tripartite motif-containing protein 33).

THAP3_HUMAN
NC score	0.000128 (rank : 1900)	θ value	8.99809 (rank : 1916)
Query Neighborhood Hits	1931	Target Neighborhood Hits	36	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WTV1, Q569K1, Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3	Gene names	THAP3
Domain Architecture
Description	THAP domain-containing protein 3.

ADA12_MOUSE
NC score	0.000113 (rank : 1901)	θ value	5.27518 (rank : 1694)
Query Neighborhood Hits	1931	Target Neighborhood Hits	474	Shared Neighborhood Hits	139
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

CLCN1_MOUSE
NC score	0.000071 (rank : 1902)	θ value	4.03905 (rank : 1634)
Query Neighborhood Hits	1931	Target Neighborhood Hits	61	Shared Neighborhood Hits	17
SwissProt Accessions	Q64347	Gene names	Clcn1, Clc1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

HB2P_HUMAN
NC score	-0.000127 (rank : 1903)	θ value	0.365318 (rank : 1273)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	36
SwissProt Accessions	P04440, O19698, O19700, O19702	Gene names	HLA-DPB1
Domain Architecture
Description	HLA class II histocompatibility antigen, DP(W4) beta chain precursor.

ZDHC5_MOUSE
NC score	-0.000136 (rank : 1904)	θ value	2.36792 (rank : 1573)
Query Neighborhood Hits	1931	Target Neighborhood Hits	113	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VDZ4, Q69ZB5, Q8R2X7	Gene names	Zdhhc5, Kiaa1748
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC5 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 5) (DHHC-5).

CHD1_HUMAN
NC score	-0.000181 (rank : 1905)	θ value	4.03905 (rank : 1633)
Query Neighborhood Hits	1931	Target Neighborhood Hits	337	Shared Neighborhood Hits	51
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

HV49_MOUSE
NC score	-0.000188 (rank : 1906)	θ value	0.62314 (rank : 1336)
Query Neighborhood Hits	1931	Target Neighborhood Hits	232	Shared Neighborhood Hits	44
SwissProt Accessions	P06328	Gene names
Domain Architecture
Description	Ig heavy chain V region VH558 B4 precursor.

PHF8_MOUSE
NC score	-0.000282 (rank : 1907)	θ value	3.0926 (rank : 1611)
Query Neighborhood Hits	1931	Target Neighborhood Hits	96	Shared Neighborhood Hits	17
SwissProt Accessions	Q80TJ7, Q8BLX8, Q8BLY0, Q8BZ61, Q8CG26	Gene names	Phf8, Kiaa1111
Domain Architecture	No domain graphic available
Description	PHD finger protein 8.

LV4D_HUMAN
NC score	-0.000314 (rank : 1908)	θ value	5.27518 (rank : 1726)
Query Neighborhood Hits	1931	Target Neighborhood Hits	199	Shared Neighborhood Hits	56
SwissProt Accessions	P01718	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-IV region Kern.

G3BP2_HUMAN
NC score	-0.000329 (rank : 1909)	θ value	2.36792 (rank : 1545)
Query Neighborhood Hits	1931	Target Neighborhood Hits	260	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

HB2Q_HUMAN
NC score	-0.000333 (rank : 1910)	θ value	0.365318 (rank : 1274)
Query Neighborhood Hits	1931	Target Neighborhood Hits	212	Shared Neighborhood Hits	36
SwissProt Accessions	P13763	Gene names
Domain Architecture
Description	HLA class II histocompatibility antigen, DP(W2) beta chain precursor (SB-2-beta).

CBX6_MOUSE
NC score	-0.000352 (rank : 1911)	θ value	4.03905 (rank : 1628)
Query Neighborhood Hits	1931	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q9DBY5, Q8BZH5	Gene names	Cbx6
Domain Architecture
Description	Chromobox protein homolog 6.

HV04_MOUSE
NC score	-0.000356 (rank : 1912)	θ value	0.0330416 (rank : 1094)
Query Neighborhood Hits	1931	Target Neighborhood Hits	243	Shared Neighborhood Hits	45
SwissProt Accessions	P01748	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region 23 precursor.

PARD3_MOUSE
NC score	-0.000465 (rank : 1913)	θ value	8.99809 (rank : 1887)
Query Neighborhood Hits	1931	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q99NH2	Gene names	Pard3, Par3
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP).

DCBD1_HUMAN
NC score	-0.000503 (rank : 1914)	θ value	4.03905 (rank : 1643)
Query Neighborhood Hits	1931	Target Neighborhood Hits	110	Shared Neighborhood Hits	18
SwissProt Accessions	Q8N8Z6, Q5H992, Q8IYK5, Q8N7L9, Q96NH2	Gene names	DCBLD1
Domain Architecture	No domain graphic available
Description	Discoidin, CUB and LCCL domain-containing protein 1 precursor.

ABP1_HUMAN
NC score	-0.000598 (rank : 1915)	θ value	6.88961 (rank : 1749)
Query Neighborhood Hits	1931	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P19801, Q16683, Q16684, Q56II4, Q6GU42	Gene names	ABP1, AOC1, DAO1
Domain Architecture
Description	Amiloride-sensitive amine oxidase [copper-containing] precursor (EC 1.4.3.6) (Diamine oxidase) (DAO) (Amiloride-binding protein) (ABP) (Histaminase) (Kidney amine oxidase) (KAO).

GP113_HUMAN
NC score	-0.000703 (rank : 1916)	θ value	0.365318 (rank : 1272)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IZF5, Q6UXT7, Q6UXX3, Q86SL7, Q8IXD8, Q8TDT3	Gene names	GPR113, PGR23
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 113 precursor (G-protein coupled receptor PGR23).

LV4B_HUMAN
NC score	-0.000708 (rank : 1917)	θ value	5.27518 (rank : 1725)
Query Neighborhood Hits	1931	Target Neighborhood Hits	202	Shared Neighborhood Hits	54
SwissProt Accessions	P01716	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-IV region X.

ZDHC9_HUMAN
NC score	-0.000761 (rank : 1918)	θ value	2.36792 (rank : 1574)
Query Neighborhood Hits	1931	Target Neighborhood Hits	69	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y397, Q59EK4, Q5JSW5, Q8WWS7, Q9BPY4, Q9NSP0, Q9NVL0, Q9NVR6	Gene names	ZDHHC9, ZNF379
Domain Architecture
Description	Palmitoyltransferase ZDHHC9 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 9) (DHHC-9) (DHHC9) (Zinc finger protein 379).

ZDH18_HUMAN
NC score	-0.000769 (rank : 1919)	θ value	2.36792 (rank : 1572)
Query Neighborhood Hits	1931	Target Neighborhood Hits	72	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NUE0, Q5JYH0, Q9H020	Gene names	ZDHHC18
Domain Architecture
Description	Palmitoyltransferase ZDHHC18 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 18) (DHHC-18).

SI1L1_MOUSE
NC score	-0.000778 (rank : 1920)	θ value	6.88961 (rank : 1802)
Query Neighborhood Hits	1931	Target Neighborhood Hits	189	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

XKR6_HUMAN
NC score	-0.000827 (rank : 1921)	θ value	6.88961 (rank : 1815)
Query Neighborhood Hits	1931	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q5GH73, Q8TBA0	Gene names	XKR6, C8orf21, C8orf7, XRG6
Domain Architecture	No domain graphic available
Description	XK-related protein 6.

PARD3_HUMAN
NC score	-0.000863 (rank : 1922)	θ value	6.88961 (rank : 1797)
Query Neighborhood Hits	1931	Target Neighborhood Hits	312	Shared Neighborhood Hits	42
SwissProt Accessions	Q8TEW0, Q8TEW1, Q8TEW2, Q8TEW3, Q96K28, Q96RM6, Q96RM7, Q9BY57, Q9BY58, Q9HC48, Q9NWL4, Q9NYE6	Gene names	PARD3, PAR3, PAR3A
Domain Architecture
Description	Partitioning-defective 3 homolog (PARD-3) (PAR-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2- 5) (PAR3-alpha).

MMP9_MOUSE
NC score	-0.000889 (rank : 1923)	θ value	8.99809 (rank : 1880)
Query Neighborhood Hits	1931	Target Neighborhood Hits	151	Shared Neighborhood Hits	39
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

RGS12_HUMAN
NC score	-0.000921 (rank : 1924)	θ value	8.99809 (rank : 1897)
Query Neighborhood Hits	1931	Target Neighborhood Hits	333	Shared Neighborhood Hits	73
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

EDEM1_HUMAN
NC score	-0.001083 (rank : 1925)	θ value	6.88961 (rank : 1768)
Query Neighborhood Hits	1931	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

HV11_MOUSE
NC score	-0.001105 (rank : 1926)	θ value	0.365318 (rank : 1277)
Query Neighborhood Hits	1931	Target Neighborhood Hits	239	Shared Neighborhood Hits	48
SwissProt Accessions	P01755	Gene names
Domain Architecture
Description	Ig heavy chain V region S43 precursor.

HV07_MOUSE
NC score	-0.001238 (rank : 1927)	θ value	0.365318 (rank : 1275)
Query Neighborhood Hits	1931	Target Neighborhood Hits	246	Shared Neighborhood Hits	51
SwissProt Accessions	P01751, P01752	Gene names
Domain Architecture
Description	Ig heavy chain V region B1-8/186-2 precursor.

HV48_MOUSE
NC score	-0.001279 (rank : 1928)	θ value	0.0431538 (rank : 1118)
Query Neighborhood Hits	1931	Target Neighborhood Hits	246	Shared Neighborhood Hits	45
SwissProt Accessions	P03980	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region TEPC 1017 precursor.

GAK8_HUMAN
NC score	-0.001292 (rank : 1929)	θ value	2.36792 (rank : 1546)
Query Neighborhood Hits	1931	Target Neighborhood Hits	145	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HDB9	Gene names	ERVK5
Domain Architecture	No domain graphic available
Description	HERV-K_3q12.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(II) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HV10_MOUSE
NC score	-0.001332 (rank : 1930)	θ value	1.06291 (rank : 1407)
Query Neighborhood Hits	1931	Target Neighborhood Hits	181	Shared Neighborhood Hits	38
SwissProt Accessions	P01754, P11270	Gene names	Igh-VJ558
Domain Architecture
Description	Ig heavy chain V region 145 precursor.

LV2A_HUMAN
NC score	-0.001335 (rank : 1931)	θ value	3.0926 (rank : 1605)
Query Neighborhood Hits	1931	Target Neighborhood Hits	269	Shared Neighborhood Hits	63
SwissProt Accessions	P01704	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region TOG.

SYIM_MOUSE
NC score	-0.001434 (rank : 1932)	θ value	8.99809 (rank : 1912)
Query Neighborhood Hits	1931	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BIJ6, Q3TKT8, Q8BIJ0, Q8BIP3	Gene names	Iars2
Domain Architecture	No domain graphic available
Description	Isoleucyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS).

HV09_MOUSE
NC score	-0.001447 (rank : 1933)	θ value	0.365318 (rank : 1276)
Query Neighborhood Hits	1931	Target Neighborhood Hits	225	Shared Neighborhood Hits	45
SwissProt Accessions	P01753, P11271	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region 186-1 precursor.

S27A5_HUMAN
NC score	-0.001479 (rank : 1934)	θ value	2.36792 (rank : 1566)
Query Neighborhood Hits	1931	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y2P5	Gene names	SLC27A5, ACSB, ACSVL6, FACVL3, FATP5
Domain Architecture	No domain graphic available
Description	Bile acyl-CoA synthetase (EC 6.2.1.7) (BACS) (Bile acid CoA ligase) (BA-CoA ligase) (BAL) (Cholate--CoA ligase) (Very long-chain acyl-CoA synthetase homolog 2) (VLCSH2) (VLCS-H2) (Very long chain acyl-CoA synthetase-related protein) (VLACS-related) (VLACSR) (Fatty-acid- coenzyme A ligase, very long-chain 3) (Fatty acid transport protein 5) (FATP-5) (Solute carrier family 27 member 5).

CLCN2_HUMAN
NC score	-0.001499 (rank : 1935)	θ value	6.88961 (rank : 1762)
Query Neighborhood Hits	1931	Target Neighborhood Hits	46	Shared Neighborhood Hits	11
SwissProt Accessions	P51788, O14864, Q8WU13	Gene names	CLCN2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

DDX51_HUMAN
NC score	-0.001573 (rank : 1936)	θ value	1.38821 (rank : 1445)
Query Neighborhood Hits	1931	Target Neighborhood Hits	332	Shared Neighborhood Hits	81
SwissProt Accessions	Q8N8A6, Q5CZ71, Q8IXK5, Q96ED1	Gene names	DDX51
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX51 (EC 3.6.1.-) (DEAD box protein 51).

RA54B_HUMAN
NC score	-0.001578 (rank : 1937)	θ value	6.88961 (rank : 1799)
Query Neighborhood Hits	1931	Target Neighborhood Hits	54	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y620	Gene names	RAD54B
Domain Architecture	No domain graphic available
Description	DNA repair and recombination protein RAD54B (EC 3.6.1.-) (RAD54 homolog B).

VPP2_MOUSE
NC score	-0.001618 (rank : 1938)	θ value	6.88961 (rank : 1812)
Query Neighborhood Hits	1931	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	P15920, Q3U2X3, Q9JHJ2	Gene names	Atp6v0a2, Atp6n1b, Tj6
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 (V- ATPase 116 kDa isoform a2) (Immune suppressor factor J6B7).

HES6_HUMAN
NC score	-0.001640 (rank : 1939)	θ value	6.88961 (rank : 1778)
Query Neighborhood Hits	1931	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HV15_MOUSE
NC score	-0.001749 (rank : 1940)	θ value	5.27518 (rank : 1716)
Query Neighborhood Hits	1931	Target Neighborhood Hits	170	Shared Neighborhood Hits	45
SwissProt Accessions	P01759	Gene names
Domain Architecture
Description	Ig heavy chain V region BCL1 precursor.

TFEB_MOUSE
NC score	-0.001817 (rank : 1941)	θ value	8.99809 (rank : 1915)
Query Neighborhood Hits	1931	Target Neighborhood Hits	119	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

G3BP2_MOUSE
NC score	-0.001991 (rank : 1942)	θ value	8.99809 (rank : 1853)
Query Neighborhood Hits	1931	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

LV1E_HUMAN
NC score	-0.001999 (rank : 1943)	θ value	2.36792 (rank : 1552)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	59
SwissProt Accessions	P01703	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region NEWM.

CE005_MOUSE
NC score	-0.002139 (rank : 1944)	θ value	6.88961 (rank : 1760)
Query Neighborhood Hits	1931	Target Neighborhood Hits	238	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

NALP5_HUMAN
NC score	-0.002303 (rank : 1945)	θ value	2.36792 (rank : 1558)
Query Neighborhood Hits	1931	Target Neighborhood Hits	88	Shared Neighborhood Hits	8
SwissProt Accessions	P59047, Q86W29	Gene names	NALP5, MATER
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Mater protein homolog).

KV3H_HUMAN
NC score	-0.002474 (rank : 1946)	θ value	3.0926 (rank : 1600)
Query Neighborhood Hits	1931	Target Neighborhood Hits	285	Shared Neighborhood Hits	71
SwissProt Accessions	P04207	Gene names
Domain Architecture
Description	Ig kappa chain V-III region CLL precursor (Rheumatoid factor).

EPAS1_MOUSE
NC score	-0.002570 (rank : 1947)	θ value	8.99809 (rank : 1849)
Query Neighborhood Hits	1931	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

BTBD7_HUMAN
NC score	-0.002682 (rank : 1948)	θ value	6.88961 (rank : 1756)
Query Neighborhood Hits	1931	Target Neighborhood Hits	176	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P203, Q69Z05, Q7Z308, Q86TS0, Q9HAA4, Q9NVM0	Gene names	BTBD7, KIAA1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

HV50_MOUSE
NC score	-0.002704 (rank : 1949)	θ value	1.06291 (rank : 1408)
Query Neighborhood Hits	1931	Target Neighborhood Hits	222	Shared Neighborhood Hits	43
SwissProt Accessions	P06329	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region AC38 15.3.

TBX21_MOUSE
NC score	-0.002744 (rank : 1950)	θ value	4.03905 (rank : 1686)
Query Neighborhood Hits	1931	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JKD8, Q9R0A6	Gene names	Tbx21, Tbet, Tblym
Domain Architecture	No domain graphic available
Description	T-box transcription factor TBX21 (T-box protein 21) (Transcription factor TBLYM) (T-cell-specific T-box transcription factor T-bet).

JAD1C_HUMAN
NC score	-0.002769 (rank : 1951)	θ value	6.88961 (rank : 1786)
Query Neighborhood Hits	1931	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	P41229	Gene names	SMCX, DXS1272E, JARID1C, XE169
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1C (Protein SmcX) (Protein Xe169).

B3A2_MOUSE
NC score	-0.003041 (rank : 1952)	θ value	8.99809 (rank : 1822)
Query Neighborhood Hits	1931	Target Neighborhood Hits	64	Shared Neighborhood Hits	14
SwissProt Accessions	P13808, Q9ES09, Q9ES10, Q9ES11, Q9ES12, Q9ES13	Gene names	Slc4a2, Ae2
Domain Architecture
Description	Anion exchange protein 2 (Non-erythroid band 3-like protein) (AE2 anion exchanger) (Solute carrier family 4 member 2) (B3RP).

HV06_MOUSE
NC score	-0.003053 (rank : 1953)	θ value	6.88961 (rank : 1781)
Query Neighborhood Hits	1931	Target Neighborhood Hits	259	Shared Neighborhood Hits	49
SwissProt Accessions	P01750	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region 102 precursor.

HV14_MOUSE
NC score	-0.003069 (rank : 1954)	θ value	4.03905 (rank : 1657)
Query Neighborhood Hits	1931	Target Neighborhood Hits	222	Shared Neighborhood Hits	43
SwissProt Accessions	P01758	Gene names	Igh-VJ558
Domain Architecture
Description	Ig heavy chain V region 108A precursor.

CSTFT_HUMAN
NC score	-0.003224 (rank : 1955)	θ value	1.38821 (rank : 1444)
Query Neighborhood Hits	1931	Target Neighborhood Hits	292	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H0L4, O75174, Q53HK6, Q7LGE8, Q8N6T1	Gene names	CSTF2T, KIAA0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

HV52_MOUSE
NC score	-0.003248 (rank : 1956)	θ value	4.03905 (rank : 1658)
Query Neighborhood Hits	1931	Target Neighborhood Hits	187	Shared Neighborhood Hits	30
SwissProt Accessions	P06327	Gene names
Domain Architecture
Description	Ig heavy chain V region VH558 A1/A4 precursor.

LV2H_HUMAN
NC score	-0.003284 (rank : 1957)	θ value	1.81305 (rank : 1500)
Query Neighborhood Hits	1931	Target Neighborhood Hits	257	Shared Neighborhood Hits	55
SwissProt Accessions	P01711	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region VIL.

HV03_MOUSE
NC score	-0.003386 (rank : 1958)	θ value	3.0926 (rank : 1595)
Query Neighborhood Hits	1931	Target Neighborhood Hits	203	Shared Neighborhood Hits	44
SwissProt Accessions	P01747	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V region 36-65.

TRI47_MOUSE
NC score	-0.003596 (rank : 1959)	θ value	0.279714 (rank : 1260)
Query Neighborhood Hits	1931	Target Neighborhood Hits	295	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

HV02_MOUSE
NC score	-0.003698 (rank : 1960)	θ value	3.0926 (rank : 1594)
Query Neighborhood Hits	1931	Target Neighborhood Hits	223	Shared Neighborhood Hits	44
SwissProt Accessions	P01746	Gene names
Domain Architecture
Description	Ig heavy chain V region 93G7 precursor.

ATP7B_HUMAN
NC score	-0.003723 (rank : 1961)	θ value	5.27518 (rank : 1701)
Query Neighborhood Hits	1931	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	P35670, Q16318, Q16319, Q4U3V3, Q59FJ9, Q5T7X7	Gene names	ATP7B, PWD, WC1, WND
Domain Architecture
Description	Copper-transporting ATPase 2 (EC 3.6.3.4) (Copper pump 2) (Wilson disease-associated protein).

LV2K_HUMAN
NC score	-0.003737 (rank : 1962)	θ value	1.81305 (rank : 1501)
Query Neighborhood Hits	1931	Target Neighborhood Hits	271	Shared Neighborhood Hits	61
SwissProt Accessions	P04209	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region NIG-84.

WDR33_HUMAN
NC score	-0.003744 (rank : 1963)	θ value	0.62314 (rank : 1357)
Query Neighborhood Hits	1931	Target Neighborhood Hits	638	Shared Neighborhood Hits	131
SwissProt Accessions	Q9C0J8	Gene names	WDR33, WDC146
Domain Architecture
Description	WD repeat protein 33 (WD repeat protein WDC146).

NECD_MOUSE
NC score	-0.003866 (rank : 1964)	θ value	6.88961 (rank : 1793)
Query Neighborhood Hits	1931	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	P25233, Q542W7, Q61951	Gene names	Ndn
Domain Architecture
Description	Necdin.

CENA2_MOUSE
NC score	-0.003889 (rank : 1965)	θ value	4.03905 (rank : 1631)
Query Neighborhood Hits	1931	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

LV2F_HUMAN
NC score	-0.003969 (rank : 1966)	θ value	0.813845 (rank : 1380)
Query Neighborhood Hits	1931	Target Neighborhood Hits	253	Shared Neighborhood Hits	53
SwissProt Accessions	P01709	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region MGC.

JAD1D_HUMAN
NC score	-0.003987 (rank : 1967)	θ value	5.27518 (rank : 1720)
Query Neighborhood Hits	1931	Target Neighborhood Hits	147	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BY66, Q92509, Q92809, Q9HCU1	Gene names	SMCY, HY, HYA, JARID1D, KIAA0234
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

FCN3_HUMAN
NC score	-0.003997 (rank : 1968)	θ value	8.99809 (rank : 1851)
Query Neighborhood Hits	1931	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	O75636, Q6IBJ5, Q8WW86	Gene names	FCN3, HAKA1
Domain Architecture
Description	Ficolin-3 precursor (Collagen/fibrinogen domain-containing protein 3) (Collagen/fibrinogen domain-containing lectin 3 p35) (Hakata antigen).

LV1B_HUMAN
NC score	-0.004195 (rank : 1969)	θ value	4.03905 (rank : 1664)
Query Neighborhood Hits	1931	Target Neighborhood Hits	237	Shared Neighborhood Hits	54
SwissProt Accessions	P01700	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region HA.

ITA2B_HUMAN
NC score	-0.004209 (rank : 1970)	θ value	2.36792 (rank : 1549)
Query Neighborhood Hits	1931	Target Neighborhood Hits	41	Shared Neighborhood Hits	2
SwissProt Accessions	P08514, O95366, Q14443	Gene names	ITGA2B, GP2B, ITGAB
Domain Architecture
Description	Integrin alpha-IIb precursor (Platelet membrane glycoprotein IIb) (GPalpha IIb) (GPIIb) (CD41 antigen) [Contains: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain].

LV2J_HUMAN
NC score	-0.004268 (rank : 1971)	θ value	0.365318 (rank : 1282)
Query Neighborhood Hits	1931	Target Neighborhood Hits	219	Shared Neighborhood Hits	45
SwissProt Accessions	P01713	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region NIG-58.

FREA_HUMAN
NC score	-0.004288 (rank : 1972)	θ value	1.06291 (rank : 1405)
Query Neighborhood Hits	1931	Target Neighborhood Hits	205	Shared Neighborhood Hits	64
SwissProt Accessions	O43638, Q96D28	Gene names	FKHL18, FREAC10
Domain Architecture	No domain graphic available
Description	Forkhead-related transcription factor 10 (FREAC-10) (Forkhead-like 18 protein).

HV1F_HUMAN
NC score	-0.004317 (rank : 1973)	θ value	5.27518 (rank : 1717)
Query Neighborhood Hits	1931	Target Neighborhood Hits	183	Shared Neighborhood Hits	39
SwissProt Accessions	P06326	Gene names
Domain Architecture	No domain graphic available
Description	Ig heavy chain V-I region Mot.

LV1G_HUMAN
NC score	-0.004317 (rank : 1974)	θ value	2.36792 (rank : 1553)
Query Neighborhood Hits	1931	Target Neighborhood Hits	266	Shared Neighborhood Hits	56
SwissProt Accessions	P06316	Gene names
Domain Architecture
Description	Ig lambda chain V-I region BL2 precursor.

HV1B_HUMAN
NC score	-0.004465 (rank : 1975)	θ value	8.99809 (rank : 1863)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	54
SwissProt Accessions	P01743	Gene names
Domain Architecture
Description	Ig heavy chain V-I region HG3 precursor.

LV1D_HUMAN
NC score	-0.004500 (rank : 1976)	θ value	4.03905 (rank : 1665)
Query Neighborhood Hits	1931	Target Neighborhood Hits	258	Shared Neighborhood Hits	53
SwissProt Accessions	P01702	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region NIG-64.

KV1M_HUMAN
NC score	-0.004502 (rank : 1977)	θ value	8.99809 (rank : 1870)
Query Neighborhood Hits	1931	Target Neighborhood Hits	249	Shared Neighborhood Hits	63
SwissProt Accessions	P01605	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-I region Lay.

LV1H_HUMAN
NC score	-0.004643 (rank : 1978)	θ value	4.03905 (rank : 1666)
Query Neighborhood Hits	1931	Target Neighborhood Hits	255	Shared Neighborhood Hits	51
SwissProt Accessions	P06887	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region MEM.

KV5O_MOUSE
NC score	-0.004670 (rank : 1979)	θ value	8.99809 (rank : 1873)
Query Neighborhood Hits	1931	Target Neighborhood Hits	211	Shared Neighborhood Hits	55
SwissProt Accessions	P01648	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region HP 91A3.

PCOC1_HUMAN
NC score	-0.004691 (rank : 1980)	θ value	8.99809 (rank : 1889)
Query Neighborhood Hits	1931	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	Q15113, O14550	Gene names	PCOLCE, PCPE1
Domain Architecture
Description	Procollagen C-endopeptidase enhancer 1 precursor (Procollagen COOH- terminal proteinase enhancer 1) (Procollagen C-proteinase enhancer 1) (PCPE-1) (Type I procollagen COOH-terminal proteinase enhancer) (Type 1 procollagen C-proteinase enhancer protein).

LV2G_HUMAN
NC score	-0.004746 (rank : 1981)	θ value	1.81305 (rank : 1499)
Query Neighborhood Hits	1931	Target Neighborhood Hits	263	Shared Neighborhood Hits	53
SwissProt Accessions	P01710	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region BO.

SCN5A_HUMAN
NC score	-0.004837 (rank : 1982)	θ value	4.03905 (rank : 1679)
Query Neighborhood Hits	1931	Target Neighborhood Hits	145	Shared Neighborhood Hits	22
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

LV2B_HUMAN
NC score	-0.004866 (rank : 1983)	θ value	8.99809 (rank : 1877)
Query Neighborhood Hits	1931	Target Neighborhood Hits	234	Shared Neighborhood Hits	53
SwissProt Accessions	P01705	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region NEI.

PO6F2_MOUSE
NC score	-0.004970 (rank : 1984)	θ value	8.99809 (rank : 1894)
Query Neighborhood Hits	1931	Target Neighborhood Hits	639	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

SC10A_MOUSE
NC score	-0.005060 (rank : 1985)	θ value	6.88961 (rank : 1801)
Query Neighborhood Hits	1931	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

MMP15_MOUSE
NC score	-0.005104 (rank : 1986)	θ value	2.36792 (rank : 1555)
Query Neighborhood Hits	1931	Target Neighborhood Hits	102	Shared Neighborhood Hits	24
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

KV4A_MOUSE
NC score	-0.005122 (rank : 1987)	θ value	1.81305 (rank : 1498)
Query Neighborhood Hits	1931	Target Neighborhood Hits	264	Shared Neighborhood Hits	71
SwissProt Accessions	P01680	Gene names
Domain Architecture
Description	Ig kappa chain V-IV region S107B precursor.

LV1F_HUMAN
NC score	-0.005156 (rank : 1988)	θ value	3.0926 (rank : 1604)
Query Neighborhood Hits	1931	Target Neighborhood Hits	266	Shared Neighborhood Hits	54
SwissProt Accessions	P04208	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region WAH.

LV6D_HUMAN
NC score	-0.005169 (rank : 1989)	θ value	8.99809 (rank : 1878)
Query Neighborhood Hits	1931	Target Neighborhood Hits	268	Shared Neighborhood Hits	54
SwissProt Accessions	P06318	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-VI region WLT.

FOXJ1_MOUSE
NC score	-0.005253 (rank : 1990)	θ value	2.36792 (rank : 1544)
Query Neighborhood Hits	1931	Target Neighborhood Hits	209	Shared Neighborhood Hits	57
SwissProt Accessions	Q61660	Gene names	Foxj1, Fkhl13, Hfh4
Domain Architecture
Description	Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4).

SCND2_HUMAN
NC score	-0.005443 (rank : 1991)	θ value	2.36792 (rank : 1567)
Query Neighborhood Hits	1931	Target Neighborhood Hits	86	Shared Neighborhood Hits	14
SwissProt Accessions	Q9GZW5, Q9H9G1	Gene names	SCAND2
Domain Architecture
Description	SCAN domain-containing protein 2.

LV2E_HUMAN
NC score	-0.005538 (rank : 1992)	θ value	5.27518 (rank : 1724)
Query Neighborhood Hits	1931	Target Neighborhood Hits	259	Shared Neighborhood Hits	54
SwissProt Accessions	P01708	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-II region BUR.

IRX6_MOUSE
NC score	-0.005593 (rank : 1993)	θ value	1.38821 (rank : 1455)
Query Neighborhood Hits	1931	Target Neighborhood Hits	256	Shared Neighborhood Hits	19
SwissProt Accessions	Q9ER75	Gene names	Irx6, Irxb3
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-6 (Iroquois homeobox protein 6) (Homeodomain protein IRXB3).

K1H5_HUMAN
NC score	-0.005673 (rank : 1994)	θ value	1.38821 (rank : 1457)
Query Neighborhood Hits	1931	Target Neighborhood Hits	362	Shared Neighborhood Hits	34
SwissProt Accessions	Q92764, O76012, Q92651	Gene names	KRTHA5, HHA5, HKA5
Domain Architecture
Description	Keratin, type I cuticular Ha5 (Hair keratin, type I Ha5).

IRX1_HUMAN
NC score	-0.005760 (rank : 1995)	θ value	8.99809 (rank : 1868)
Query Neighborhood Hits	1931	Target Neighborhood Hits	285	Shared Neighborhood Hits	32
SwissProt Accessions	P78414, Q7Z2F8, Q8N312	Gene names	IRX1, IRXA1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-1 (Iroquois homeobox protein 1) (Homeodomain protein IRXA1).

KV5G_MOUSE
NC score	-0.006311 (rank : 1996)	θ value	3.0926 (rank : 1601)
Query Neighborhood Hits	1931	Target Neighborhood Hits	228	Shared Neighborhood Hits	60
SwissProt Accessions	P01639, P01640	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region MOPC 41 precursor.

KV5M_MOUSE
NC score	-0.006581 (rank : 1997)	θ value	8.99809 (rank : 1872)
Query Neighborhood Hits	1931	Target Neighborhood Hits	210	Shared Neighborhood Hits	49
SwissProt Accessions	P01646	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-V region HP 123E6.

RXRB_HUMAN
NC score	-0.006608 (rank : 1998)	θ value	1.06291 (rank : 1423)
Query Neighborhood Hits	1931	Target Neighborhood Hits	280	Shared Neighborhood Hits	72
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

KV3F_HUMAN
NC score	-0.006771 (rank : 1999)	θ value	8.99809 (rank : 1871)
Query Neighborhood Hits	1931	Target Neighborhood Hits	283	Shared Neighborhood Hits	70
SwissProt Accessions	P01624	Gene names
Domain Architecture	No domain graphic available
Description	Ig kappa chain V-III region POM.

HXA3_MOUSE
NC score	-0.007036 (rank : 2000)	θ value	0.62314 (rank : 1338)
Query Neighborhood Hits	1931	Target Neighborhood Hits	558	Shared Neighborhood Hits	105
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

HXA3_HUMAN
NC score	-0.007139 (rank : 2001)	θ value	0.62314 (rank : 1337)
Query Neighborhood Hits	1931	Target Neighborhood Hits	535	Shared Neighborhood Hits	89
SwissProt Accessions	O43365	Gene names	HOXA3, HOX1E
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1E).

FOXD2_HUMAN
NC score	-0.007468 (rank : 2002)	θ value	6.88961 (rank : 1774)
Query Neighborhood Hits	1931	Target Neighborhood Hits	143	Shared Neighborhood Hits	23
SwissProt Accessions	O60548	Gene names	FOXD2, FKHL17, FREAC9
Domain Architecture
Description	Forkhead box protein D2 (Forkhead-related protein FKHL17) (Forkhead- related transcription factor 9) (FREAC-9).

WDR43_HUMAN
NC score	-0.008342 (rank : 2003)	θ value	8.99809 (rank : 1924)
Query Neighborhood Hits	1931	Target Neighborhood Hits	269	Shared Neighborhood Hits	14
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

HXB3_HUMAN
NC score	-0.008361 (rank : 2004)	θ value	0.365318 (rank : 1278)
Query Neighborhood Hits	1931	Target Neighborhood Hits	559	Shared Neighborhood Hits	118
SwissProt Accessions	P14651, O95615, P17484	Gene names	HOXB3, HOX2G
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2G) (Hox-2.7).

ATBF1_MOUSE
NC score	-0.008613 (rank : 2005)	θ value	0.00390308 (rank : 1014)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1841	Shared Neighborhood Hits	227
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

HXB3_MOUSE
NC score	-0.009089 (rank : 2006)	θ value	0.163984 (rank : 1211)
Query Neighborhood Hits	1931	Target Neighborhood Hits	493	Shared Neighborhood Hits	89
SwissProt Accessions	P09026, P10285, Q4PJ06, Q61680	Gene names	Hoxb3, Hox-2.7, Hoxb-3
Domain Architecture
Description	Homeobox protein Hox-B3 (Hox-2.7) (Homeobox protein MH-23).

ZN414_HUMAN
NC score	-0.009220 (rank : 2007)	θ value	5.27518 (rank : 1744)
Query Neighborhood Hits	1931	Target Neighborhood Hits	548	Shared Neighborhood Hits	70
SwissProt Accessions	Q96IQ9	Gene names	ZNF414
Domain Architecture	No domain graphic available
Description	Zinc finger protein 414.

VSX1_HUMAN
NC score	-0.010376 (rank : 2008)	θ value	0.0961366 (rank : 1184)
Query Neighborhood Hits	1931	Target Neighborhood Hits	344	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZR4, Q5TF40, Q5TF41, Q9HCU3, Q9NU27	Gene names	VSX1, RINX
Domain Architecture
Description	Visual system homeobox 1 (Transcription factor VSX1) (Retinal inner nuclear layer homeobox protein) (Homeodomain protein RINX).

ZN687_HUMAN
NC score	-0.010478 (rank : 2009)	θ value	0.279714 (rank : 1263)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1244	Shared Neighborhood Hits	250
SwissProt Accessions	Q8N1G0, Q68DQ8, Q9H937, Q9P2A7	Gene names	ZNF687, KIAA1441
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

TMPSD_HUMAN
NC score	-0.011404 (rank : 2010)	θ value	5.27518 (rank : 1740)
Query Neighborhood Hits	1931	Target Neighborhood Hits	333	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

RX_MOUSE
NC score	-0.011632 (rank : 2011)	θ value	0.0736092 (rank : 1153)
Query Neighborhood Hits	1931	Target Neighborhood Hits	429	Shared Neighborhood Hits	53
SwissProt Accessions	O35602, O08748	Gene names	Rax, Rx
Domain Architecture
Description	Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein).

FOG1_MOUSE
NC score	-0.012303 (rank : 2012)	θ value	2.36792 (rank : 1543)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1237	Shared Neighborhood Hits	233
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ALX4_HUMAN
NC score	-0.012862 (rank : 2013)	θ value	0.47712 (rank : 1298)
Query Neighborhood Hits	1931	Target Neighborhood Hits	394	Shared Neighborhood Hits	34
SwissProt Accessions	Q9H161, Q96JN7, Q9H198, Q9HAY9	Gene names	ALX4, KIAA1788
Domain Architecture
Description	Homeobox protein aristaless-like 4.

VSX1_MOUSE
NC score	-0.013132 (rank : 2014)	θ value	8.99809 (rank : 1923)
Query Neighborhood Hits	1931	Target Neighborhood Hits	356	Shared Neighborhood Hits	26
SwissProt Accessions	Q91V10	Gene names	Vsx1, Rinx
Domain Architecture
Description	Visual system homeobox 1 (Transcription factor VSX1) (Retinal inner nuclear layer homeobox protein) (Homeodomain protein RINX).

PC11X_HUMAN
NC score	-0.013390 (rank : 2015)	θ value	8.99809 (rank : 1888)
Query Neighborhood Hits	1931	Target Neighborhood Hits	199	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZA7, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5	Gene names	PCDH11X, PCDH11, PCDHX
Domain Architecture	No domain graphic available
Description	Protocadherin-11 X-linked precursor (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S).

HXC5_HUMAN
NC score	-0.014289 (rank : 2016)	θ value	6.88961 (rank : 1782)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	23
SwissProt Accessions	Q00444	Gene names	HOXC5, HOX3D
Domain Architecture
Description	Homeobox protein Hox-C5 (Hox-3D) (CP11).

HXC5_MOUSE
NC score	-0.014404 (rank : 2017)	θ value	8.99809 (rank : 1864)
Query Neighborhood Hits	1931	Target Neighborhood Hits	316	Shared Neighborhood Hits	24
SwissProt Accessions	P32043, Q8BJW4	Gene names	Hoxc5, Hox-3.4, Hoxc-5
Domain Architecture
Description	Homeobox protein Hox-C5 (Hox-3.4) (Hox-6.2).

FOG1_HUMAN
NC score	-0.014466 (rank : 2018)	θ value	0.813845 (rank : 1373)
Query Neighborhood Hits	1931	Target Neighborhood Hits	981	Shared Neighborhood Hits	146
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

HLX1_HUMAN
NC score	-0.015400 (rank : 2019)	θ value	8.99809 (rank : 1860)
Query Neighborhood Hits	1931	Target Neighborhood Hits	370	Shared Neighborhood Hits	27
SwissProt Accessions	Q14774, Q15988	Gene names	HLX1
Domain Architecture
Description	Homeobox protein HLX1 (Homeobox protein HB24).

ZN687_MOUSE
NC score	-0.015595 (rank : 2020)	θ value	0.0961366 (rank : 1185)
Query Neighborhood Hits	1931	Target Neighborhood Hits	913	Shared Neighborhood Hits	136
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

ZFHX2_HUMAN
NC score	-0.016187 (rank : 2021)	θ value	3.0926 (rank : 1619)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1178	Shared Neighborhood Hits	140
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

TAF5_HUMAN
NC score	-0.016217 (rank : 2022)	θ value	0.47712 (rank : 1318)
Query Neighborhood Hits	1931	Target Neighborhood Hits	352	Shared Neighborhood Hits	13
SwissProt Accessions	Q15542, Q86UZ7, Q9Y4K5	Gene names	TAF5, TAF2D
Domain Architecture
Description	Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100).

SALL3_HUMAN
NC score	-0.016230 (rank : 2023)	θ value	0.00134147 (rank : 991)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1066	Shared Neighborhood Hits	175
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

ZN516_MOUSE
NC score	-0.017111 (rank : 2024)	θ value	1.81305 (rank : 1520)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1197	Shared Neighborhood Hits	230
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ATBF1_HUMAN
NC score	-0.017980 (rank : 2025)	θ value	5.27518 (rank : 1699)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1547	Shared Neighborhood Hits	178
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ZEP2_MOUSE
NC score	-0.019488 (rank : 2026)	θ value	8.99809 (rank : 1926)
Query Neighborhood Hits	1931	Target Neighborhood Hits	964	Shared Neighborhood Hits	127
SwissProt Accessions	Q3UHF7, O55140, Q3UVD4, Q3UVH5	Gene names	Hivep2, Mibp1
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 homolog (Myc intron-binding protein 1) (MIBP-1).

ZN438_HUMAN
NC score	-0.020837 (rank : 2027)	θ value	5.27518 (rank : 1745)
Query Neighborhood Hits	1931	Target Neighborhood Hits	906	Shared Neighborhood Hits	126
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

RREB1_HUMAN
NC score	-0.021719 (rank : 2028)	θ value	0.47712 (rank : 1312)
Query Neighborhood Hits	1931	Target Neighborhood Hits	879	Shared Neighborhood Hits	95
SwissProt Accessions	Q92766, O75567	Gene names	RREB1
Domain Architecture
Description	RAS-responsive element-binding protein 1 (RREB-1) (Raf-responsive zinc finger protein LZ321).

ZN219_HUMAN
NC score	-0.022536 (rank : 2029)	θ value	8.99809 (rank : 1929)
Query Neighborhood Hits	1931	Target Neighborhood Hits	876	Shared Neighborhood Hits	111
SwissProt Accessions	Q9P2Y4, Q8IYC1, Q9BW28	Gene names	ZNF219
Domain Architecture	No domain graphic available
Description	Zinc finger protein 219.

GLIS3_MOUSE
NC score	-0.022730 (rank : 2030)	θ value	0.813845 (rank : 1374)
Query Neighborhood Hits	1931	Target Neighborhood Hits	861	Shared Neighborhood Hits	110
SwissProt Accessions	Q6XP49, Q8BI60	Gene names	Glis3
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS3 (GLI-similar 3).

ZN335_HUMAN
NC score	-0.023944 (rank : 2031)	θ value	2.36792 (rank : 1575)
Query Neighborhood Hits	1931	Target Neighborhood Hits	973	Shared Neighborhood Hits	136
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

EGR4_HUMAN
NC score	-0.024417 (rank : 2032)	θ value	1.38821 (rank : 1447)
Query Neighborhood Hits	1931	Target Neighborhood Hits	939	Shared Neighborhood Hits	151
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

DRD4_HUMAN
NC score	-0.024543 (rank : 2033)	θ value	0.813845 (rank : 1371)
Query Neighborhood Hits	1931	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	P21917	Gene names	DRD4
Domain Architecture
Description	D(4) dopamine receptor (Dopamine D4 receptor) (D(2C) dopamine receptor).

ZIC5_HUMAN
NC score	-0.025261 (rank : 2034)	θ value	5.27518 (rank : 1743)
Query Neighborhood Hits	1931	Target Neighborhood Hits	774	Shared Neighborhood Hits	80
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

ZN676_HUMAN
NC score	-0.025338 (rank : 2035)	θ value	0.0252991 (rank : 1091)
Query Neighborhood Hits	1931	Target Neighborhood Hits	754	Shared Neighborhood Hits	51
SwissProt Accessions	Q8N7Q3	Gene names	ZNF676
Domain Architecture	No domain graphic available
Description	Zinc finger protein 676.

ZN358_HUMAN
NC score	-0.025433 (rank : 2036)	θ value	1.38821 (rank : 1476)
Query Neighborhood Hits	1931	Target Neighborhood Hits	840	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

ZNF91_HUMAN
NC score	-0.025620 (rank : 2037)	θ value	0.62314 (rank : 1358)
Query Neighborhood Hits	1931	Target Neighborhood Hits	797	Shared Neighborhood Hits	56
SwissProt Accessions	Q05481	Gene names	ZNF91
Domain Architecture
Description	Zinc finger protein 91 (Zinc finger protein HTF10) (HPF7).

ZN595_HUMAN
NC score	-0.025660 (rank : 2038)	θ value	4.03905 (rank : 1693)
Query Neighborhood Hits	1931	Target Neighborhood Hits	798	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IYB9	Gene names	ZNF595
Domain Architecture	No domain graphic available
Description	Zinc finger protein 595.

EVI1_HUMAN
NC score	-0.025755 (rank : 2039)	θ value	6.88961 (rank : 1772)
Query Neighborhood Hits	1931	Target Neighborhood Hits	924	Shared Neighborhood Hits	84
SwissProt Accessions	Q03112, Q16122, Q99917	Gene names	EVI1
Domain Architecture
Description	Ecotropic virus integration 1 site protein.

ZN206_HUMAN
NC score	-0.025905 (rank : 2040)	θ value	4.03905 (rank : 1691)
Query Neighborhood Hits	1931	Target Neighborhood Hits	853	Shared Neighborhood Hits	90
SwissProt Accessions	Q96SZ4	Gene names	ZNF206, ZSCAN10
Domain Architecture	No domain graphic available
Description	Zinc finger protein 206 (Zinc finger and SCAN domain-containing protein 10).

ZNF43_HUMAN
NC score	-0.025915 (rank : 2041)	θ value	1.06291 (rank : 1433)
Query Neighborhood Hits	1931	Target Neighborhood Hits	779	Shared Neighborhood Hits	51
SwissProt Accessions	P17038, P28160, Q96DG1	Gene names	ZNF43, KOX27, ZNF39
Domain Architecture
Description	Zinc finger protein 43 (Zinc protein HTF6) (Zinc finger protein KOX27).

ZN718_HUMAN
NC score	-0.025957 (rank : 2042)	θ value	6.88961 (rank : 1818)
Query Neighborhood Hits	1931	Target Neighborhood Hits	761	Shared Neighborhood Hits	52
SwissProt Accessions	Q3SXZ3, Q3SXZ4, Q3SXZ5	Gene names	ZNF718
Domain Architecture	No domain graphic available
Description	Zinc finger protein 718.

KLF13_HUMAN
NC score	-0.026018 (rank : 2043)	θ value	3.0926 (rank : 1599)
Query Neighborhood Hits	1931	Target Neighborhood Hits	739	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y2Y9, Q9Y356	Gene names	KLF13, BTEB3, NSLP1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 13 (Transcription factor BTEB3) (Basic transcription element-binding protein 3) (BTE-binding protein 3) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor NSLP1) (Novel Sp1-like zinc finger transcription factor 1).

ZN267_HUMAN
NC score	-0.026059 (rank : 2044)	θ value	0.125558 (rank : 1200)
Query Neighborhood Hits	1931	Target Neighborhood Hits	786	Shared Neighborhood Hits	54
SwissProt Accessions	Q14586, Q8NE41, Q9NRJ0	Gene names	ZNF267
Domain Architecture
Description	Zinc finger protein 267 (Zinc finger protein HZF2).

ZN708_HUMAN
NC score	-0.026082 (rank : 2045)	θ value	1.06291 (rank : 1432)
Query Neighborhood Hits	1931	Target Neighborhood Hits	747	Shared Neighborhood Hits	48
SwissProt Accessions	P17019, Q6ZMR0	Gene names	ZNF708, KOX8, ZNF15, ZNF15L1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 708 (Zinc finger protein 15-like 1) (Zinc finger protein KOX8).

ZN479_HUMAN
NC score	-0.026131 (rank : 2046)	θ value	1.81305 (rank : 1519)
Query Neighborhood Hits	1931	Target Neighborhood Hits	746	Shared Neighborhood Hits	53
SwissProt Accessions	Q96JC4	Gene names	ZNF479
Domain Architecture
Description	Zinc finger protein 479 (Zinc finger protein Kr19) (HKr19).

ZN546_HUMAN
NC score	-0.026162 (rank : 2047)	θ value	0.47712 (rank : 1322)
Query Neighborhood Hits	1931	Target Neighborhood Hits	772	Shared Neighborhood Hits	49
SwissProt Accessions	Q86UE3	Gene names	ZNF546, ZNF49
Domain Architecture	No domain graphic available
Description	Zinc finger protein 546.

MTR1L_HUMAN
NC score	-0.026338 (rank : 2048)	θ value	0.365318 (rank : 1287)
Query Neighborhood Hits	1931	Target Neighborhood Hits	1180	Shared Neighborhood Hits	105
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

ZN619_HUMAN
NC score	-0.026453 (rank : 2049)	θ value	1.38821 (rank : 1477)
Query Neighborhood Hits	1931	Target Neighborhood Hits	749	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N2I2	Gene names	ZNF619
Domain Architecture	No domain graphic available
Description	Zinc finger protein 619.

SIP1_MOUSE
NC score	-0.026548 (rank : 2050)	θ value	6.88961 (rank : 1803)
Query Neighborhood Hits	1931	Target Neighborhood Hits	870	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R0G7	Gene names	Zfhx1b, Sip1, Zfx1b
Domain Architecture
Description	Zinc finger homeobox protein 1b (Smad-interacting protein 1).

KLF2_HUMAN
NC score	-0.026606 (rank : 2051)	θ value	8.99809 (rank : 1869)
Query Neighborhood Hits	1931	Target Neighborhood Hits	755	Shared Neighborhood Hits	72
SwissProt Accessions	Q9Y5W3, Q9UJS5, Q9UKR6	Gene names	KLF2, LKLF
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 2 (Lung krueppel-like factor).

ZN621_HUMAN
NC score	-0.026725 (rank : 2052)	θ value	5.27518 (rank : 1746)
Query Neighborhood Hits	1931	Target Neighborhood Hits	737	Shared Neighborhood Hits	46
SwissProt Accessions	Q6ZSS3, Q8TE91	Gene names	ZNF621
Domain Architecture	No domain graphic available
Description	Zinc finger protein 621.

ZN502_HUMAN
NC score	-0.026780 (rank : 2053)	θ value	6.88961 (rank : 1817)
Query Neighborhood Hits	1931	Target Neighborhood Hits	762	Shared Neighborhood Hits	47
SwissProt Accessions	Q8TBZ5	Gene names	ZNF502
Domain Architecture	No domain graphic available
Description	Zinc finger protein 502.

ZBT45_HUMAN
NC score	-0.026811 (rank : 2054)	θ value	3.0926 (rank : 1618)
Query Neighborhood Hits	1931	Target Neighborhood Hits	901	Shared Neighborhood Hits	96
SwissProt Accessions	Q96K62	Gene names	ZBTB45, ZNF499
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499).

PRD13_HUMAN
NC score	-0.026854 (rank : 2055)	θ value	5.27518 (rank : 1734)
Query Neighborhood Hits	1931	Target Neighborhood Hits	716	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H4Q3, Q5TGC1	Gene names	PRDM13, PFM10
Domain Architecture	No domain graphic available
Description	PR domain zinc finger protein 13 (PR domain-containing protein 13).

ZN713_HUMAN
NC score	-0.027334 (rank : 2056)	θ value	5.27518 (rank : 1747)
Query Neighborhood Hits	1931	Target Neighborhood Hits	728	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N859	Gene names	ZNF713
Domain Architecture	No domain graphic available
Description	Zinc finger protein 713.

ZN410_HUMAN
NC score	-0.027672 (rank : 2057)	θ value	8.99809 (rank : 1930)
Query Neighborhood Hits	1931	Target Neighborhood Hits	716	Shared Neighborhood Hits	43
SwissProt Accessions	Q86VK4, O00153, Q9BQ19	Gene names	ZNF410, APA1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 410 (Zinc finger protein APA-1) (Another partner for ARF 1).

ZBT46_HUMAN
NC score	-0.029011 (rank : 2058)	θ value	5.27518 (rank : 1741)
Query Neighborhood Hits	1931	Target Neighborhood Hits	813	Shared Neighborhood Hits	46
SwissProt Accessions	Q86UZ6, Q5JWJ3, Q9BQK3, Q9H3Z8, Q9H3Z9	Gene names	ZBTB46, BTBD4, ZNF340
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 46 (BTB/POZ domain- containing protein 4) (Zinc finger protein 340).

ADA1D_HUMAN
NC score	-0.030837 (rank : 2059)	θ value	5.27518 (rank : 1695)
Query Neighborhood Hits	1931	Target Neighborhood Hits	937	Shared Neighborhood Hits	11
SwissProt Accessions	P25100, Q9NPY0	Gene names	ADRA1D, ADRA1A
Domain Architecture
Description	Alpha-1D adrenergic receptor (Alpha 1D-adrenoceptor) (Alpha 1D- adrenoreceptor) (Alpha-1A adrenergic receptor) (Alpha adrenergic receptor 1a).