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Network neighborhood for query Sequence : CD2L7_HUMAN

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CD2L7_HUMAN
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CD2L5_HUMAN
θ value	0 (rank : 1)	NC score	0.990471 (rank : 2)
Query Neighborhood Hits	1275	Target Neighborhood Hits	987	Shared Neighborhood Hits	864
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	0 (rank : 2)	NC score	0.990379 (rank : 3)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1011	Shared Neighborhood Hits	878
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1275	Shared Neighborhood Hits	1275
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CDK9_MOUSE
θ value	1.95861e-79 (rank : 4)	NC score	0.979388 (rank : 4)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDK9_HUMAN
θ value	7.44272e-79 (rank : 5)	NC score	0.979338 (rank : 5)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK10_HUMAN
θ value	1.11475e-66 (rank : 6)	NC score	0.976460 (rank : 17)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	822
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CD2L2_HUMAN
θ value	3.03575e-64 (rank : 7)	NC score	0.963888 (rank : 61)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1439	Shared Neighborhood Hits	894
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CD2L1_HUMAN
θ value	3.96481e-64 (rank : 8)	NC score	0.961054 (rank : 66)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1467	Shared Neighborhood Hits	890
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	2.56992e-63 (rank : 9)	NC score	0.959514 (rank : 68)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1463	Shared Neighborhood Hits	888
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CDK3_HUMAN
θ value	2.56992e-63 (rank : 10)	NC score	0.978673 (rank : 7)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK2_HUMAN
θ value	9.76566e-63 (rank : 11)	NC score	0.978220 (rank : 9)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDC2_HUMAN
θ value	1.19377e-60 (rank : 12)	NC score	0.978834 (rank : 6)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	826
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CCRK_HUMAN
θ value	4.53632e-60 (rank : 13)	NC score	0.977628 (rank : 13)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	821
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CDC2_MOUSE
θ value	4.53632e-60 (rank : 14)	NC score	0.978225 (rank : 8)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK5_HUMAN
θ value	4.24587e-58 (rank : 15)	NC score	0.977613 (rank : 14)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	814
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	7.24236e-58 (rank : 16)	NC score	0.977591 (rank : 15)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	814
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CCRK_MOUSE
θ value	1.23536e-57 (rank : 17)	NC score	0.976752 (rank : 16)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	819
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

PCTK2_HUMAN
θ value	1.36585e-56 (rank : 18)	NC score	0.974403 (rank : 24)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	818
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	1.78386e-56 (rank : 19)	NC score	0.974235 (rank : 26)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	818
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_MOUSE
θ value	5.19021e-56 (rank : 20)	NC score	0.974500 (rank : 22)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	818
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDK2_MOUSE
θ value	1.97229e-55 (rank : 21)	NC score	0.977898 (rank : 12)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	821
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

PCTK1_HUMAN
θ value	1.97229e-55 (rank : 22)	NC score	0.974261 (rank : 25)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	819
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	5.73848e-55 (rank : 23)	NC score	0.974154 (rank : 27)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	817
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK3_HUMAN
θ value	7.49467e-55 (rank : 24)	NC score	0.973291 (rank : 28)
Query Neighborhood Hits	1275	Target Neighborhood Hits	827	Shared Neighborhood Hits	812
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDK7_HUMAN
θ value	1.56274e-52 (rank : 25)	NC score	0.978003 (rank : 10)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	821
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	7.75577e-52 (rank : 26)	NC score	0.977928 (rank : 11)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	821
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

PFTK1_HUMAN
θ value	2.94719e-51 (rank : 27)	NC score	0.974765 (rank : 19)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	816
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
θ value	6.56568e-51 (rank : 28)	NC score	0.974756 (rank : 20)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	816
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

CDKL5_HUMAN
θ value	1.91031e-50 (rank : 29)	NC score	0.969389 (rank : 42)
Query Neighborhood Hits	1275	Target Neighborhood Hits	967	Shared Neighborhood Hits	850
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CDKL2_HUMAN
θ value	2.49495e-50 (rank : 30)	NC score	0.972319 (rank : 32)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	822
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDK6_MOUSE
θ value	7.25919e-50 (rank : 31)	NC score	0.974704 (rank : 21)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	824
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDK6_HUMAN
θ value	9.48078e-50 (rank : 32)	NC score	0.974417 (rank : 23)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	824
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDKL4_MOUSE
θ value	1.23823e-49 (rank : 33)	NC score	0.973163 (rank : 29)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	820
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL1_HUMAN
θ value	2.75849e-49 (rank : 34)	NC score	0.969937 (rank : 40)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	820
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL1_MOUSE
θ value	1.788e-48 (rank : 35)	NC score	0.968108 (rank : 46)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	819
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

CDKL2_MOUSE
θ value	8.87376e-48 (rank : 36)	NC score	0.971593 (rank : 37)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	822
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

CD2L6_HUMAN
θ value	3.37202e-47 (rank : 37)	NC score	0.961425 (rank : 64)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

AL2S7_HUMAN
θ value	5.7518e-47 (rank : 38)	NC score	0.975115 (rank : 18)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	818
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

CDK4_MOUSE
θ value	3.72821e-46 (rank : 39)	NC score	0.972767 (rank : 31)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	823
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDKL4_HUMAN
θ value	3.72821e-46 (rank : 40)	NC score	0.971848 (rank : 36)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	818
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDK8_HUMAN
θ value	6.35935e-46 (rank : 41)	NC score	0.960270 (rank : 67)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	814
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

CD2L6_MOUSE
θ value	8.30557e-46 (rank : 42)	NC score	0.961438 (rank : 63)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	817
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CDK4_HUMAN
θ value	1.85029e-45 (rank : 43)	NC score	0.971863 (rank : 35)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	823
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

ICK_HUMAN
θ value	5.38352e-45 (rank : 44)	NC score	0.972086 (rank : 34)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	828
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

MK01_HUMAN
θ value	7.03111e-45 (rank : 45)	NC score	0.965075 (rank : 53)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	820
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
θ value	9.18288e-45 (rank : 46)	NC score	0.964999 (rank : 55)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	820
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	2.04573e-44 (rank : 47)	NC score	0.966915 (rank : 49)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

ICK_MOUSE
θ value	2.67181e-44 (rank : 48)	NC score	0.972169 (rank : 33)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	827
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MK03_MOUSE
θ value	2.67181e-44 (rank : 49)	NC score	0.966554 (rank : 50)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	824
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MAK_HUMAN
θ value	5.95217e-44 (rank : 50)	NC score	0.971151 (rank : 39)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	831
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	5.95217e-44 (rank : 51)	NC score	0.971534 (rank : 38)
Query Neighborhood Hits	1275	Target Neighborhood Hits	873	Shared Neighborhood Hits	837
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MK07_HUMAN
θ value	2.95404e-43 (rank : 52)	NC score	0.968778 (rank : 43)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1087	Shared Neighborhood Hits	919
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK12_MOUSE
θ value	3.85808e-43 (rank : 53)	NC score	0.966150 (rank : 51)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	820
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

CDK3_MOUSE
θ value	8.59492e-43 (rank : 54)	NC score	0.972922 (rank : 30)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	821
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

MK07_MOUSE
θ value	2.50074e-42 (rank : 55)	NC score	0.969654 (rank : 41)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1054	Shared Neighborhood Hits	911
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

CDKL3_MOUSE
θ value	7.27602e-42 (rank : 56)	NC score	0.968242 (rank : 45)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	829
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

MK13_MOUSE
θ value	2.11701e-41 (rank : 57)	NC score	0.964353 (rank : 57)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	819
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK04_MOUSE
θ value	2.76489e-41 (rank : 58)	NC score	0.957668 (rank : 70)
Query Neighborhood Hits	1275	Target Neighborhood Hits	852	Shared Neighborhood Hits	807
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

CDKL3_HUMAN
θ value	8.04462e-41 (rank : 59)	NC score	0.968701 (rank : 44)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	832
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

MK04_HUMAN
θ value	8.04462e-41 (rank : 60)	NC score	0.959173 (rank : 69)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK12_HUMAN
θ value	1.3722e-40 (rank : 61)	NC score	0.965907 (rank : 52)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	820
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK15_MOUSE
θ value	5.21438e-40 (rank : 62)	NC score	0.964757 (rank : 56)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	822
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

NLK_HUMAN
θ value	5.21438e-40 (rank : 63)	NC score	0.967834 (rank : 48)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	826
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	5.21438e-40 (rank : 64)	NC score	0.967883 (rank : 47)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	826
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

MK13_HUMAN
θ value	6.81017e-40 (rank : 65)	NC score	0.964248 (rank : 58)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	819
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK06_MOUSE
θ value	1.98146e-39 (rank : 66)	NC score	0.953349 (rank : 73)
Query Neighborhood Hits	1275	Target Neighborhood Hits	818	Shared Neighborhood Hits	793
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK06_HUMAN
θ value	4.41421e-39 (rank : 67)	NC score	0.953507 (rank : 72)
Query Neighborhood Hits	1275	Target Neighborhood Hits	815	Shared Neighborhood Hits	792
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK15_HUMAN
θ value	5.76516e-39 (rank : 68)	NC score	0.965038 (rank : 54)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1038	Shared Neighborhood Hits	853
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK14_MOUSE
θ value	4.88048e-38 (rank : 69)	NC score	0.964013 (rank : 59)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	823
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK14_HUMAN
θ value	1.08726e-37 (rank : 70)	NC score	0.963967 (rank : 60)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	823
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MK11_MOUSE
θ value	4.568e-36 (rank : 71)	NC score	0.961649 (rank : 62)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	825
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK11_HUMAN
θ value	7.79185e-36 (rank : 72)	NC score	0.961381 (rank : 65)
Query Neighborhood Hits	1275	Target Neighborhood Hits	823	Shared Neighborhood Hits	817
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MOK_MOUSE
θ value	4.00176e-32 (rank : 73)	NC score	0.952580 (rank : 77)
Query Neighborhood Hits	1275	Target Neighborhood Hits	796	Shared Neighborhood Hits	788
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MOK_HUMAN
θ value	8.91499e-32 (rank : 74)	NC score	0.953016 (rank : 74)
Query Neighborhood Hits	1275	Target Neighborhood Hits	807	Shared Neighborhood Hits	796
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MK10_MOUSE
θ value	2.59387e-31 (rank : 75)	NC score	0.952433 (rank : 78)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	818
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_HUMAN
θ value	7.54701e-31 (rank : 76)	NC score	0.952334 (rank : 79)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	816
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

GSK3A_HUMAN
θ value	6.38894e-30 (rank : 77)	NC score	0.954554 (rank : 71)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	798
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

GSK3B_HUMAN
θ value	6.38894e-30 (rank : 78)	NC score	0.952594 (rank : 75)
Query Neighborhood Hits	1275	Target Neighborhood Hits	801	Shared Neighborhood Hits	795
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	6.38894e-30 (rank : 79)	NC score	0.952592 (rank : 76)
Query Neighborhood Hits	1275	Target Neighborhood Hits	800	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

MK08_HUMAN
θ value	1.4233e-29 (rank : 80)	NC score	0.951604 (rank : 82)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	818
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	1.85889e-29 (rank : 81)	NC score	0.952195 (rank : 80)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	818
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK09_HUMAN
θ value	5.40856e-29 (rank : 82)	NC score	0.952143 (rank : 81)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK09_MOUSE
θ value	1.33217e-27 (rank : 83)	NC score	0.951559 (rank : 83)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	819
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

DYRK4_HUMAN
θ value	3.87602e-27 (rank : 84)	NC score	0.901789 (rank : 235)
Query Neighborhood Hits	1275	Target Neighborhood Hits	750	Shared Neighborhood Hits	740
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

CSK22_MOUSE
θ value	5.06226e-27 (rank : 85)	NC score	0.924564 (rank : 103)
Query Neighborhood Hits	1275	Target Neighborhood Hits	758	Shared Neighborhood Hits	755
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_HUMAN
θ value	1.12775e-26 (rank : 86)	NC score	0.924299 (rank : 105)
Query Neighborhood Hits	1275	Target Neighborhood Hits	758	Shared Neighborhood Hits	755
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

STK36_HUMAN
θ value	1.12775e-26 (rank : 87)	NC score	0.936997 (rank : 85)
Query Neighborhood Hits	1275	Target Neighborhood Hits	896	Shared Neighborhood Hits	833
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

NEK3_MOUSE
θ value	1.47289e-26 (rank : 88)	NC score	0.930770 (rank : 91)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	825
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

STK6_HUMAN
θ value	1.47289e-26 (rank : 89)	NC score	0.920195 (rank : 122)
Query Neighborhood Hits	1275	Target Neighborhood Hits	916	Shared Neighborhood Hits	843
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

CSK21_MOUSE
θ value	3.28125e-26 (rank : 90)	NC score	0.931858 (rank : 86)
Query Neighborhood Hits	1275	Target Neighborhood Hits	770	Shared Neighborhood Hits	763
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

STK36_MOUSE
θ value	4.28545e-26 (rank : 91)	NC score	0.941190 (rank : 84)
Query Neighborhood Hits	1275	Target Neighborhood Hits	877	Shared Neighborhood Hits	830
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

CSK21_HUMAN
θ value	5.59698e-26 (rank : 92)	NC score	0.931851 (rank : 87)
Query Neighborhood Hits	1275	Target Neighborhood Hits	772	Shared Neighborhood Hits	763
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

NEK3_HUMAN
θ value	3.62785e-25 (rank : 93)	NC score	0.931801 (rank : 88)
Query Neighborhood Hits	1275	Target Neighborhood Hits	865	Shared Neighborhood Hits	827
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

DYRK3_HUMAN
θ value	4.73814e-25 (rank : 94)	NC score	0.924478 (rank : 104)
Query Neighborhood Hits	1275	Target Neighborhood Hits	798	Shared Neighborhood Hits	784
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

STK4_MOUSE
θ value	3.07116e-24 (rank : 95)	NC score	0.915860 (rank : 147)
Query Neighborhood Hits	1275	Target Neighborhood Hits	873	Shared Neighborhood Hits	825
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK6_MOUSE
θ value	4.01107e-24 (rank : 96)	NC score	0.919395 (rank : 128)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	837
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

DYR1B_MOUSE
θ value	5.23862e-24 (rank : 97)	NC score	0.909723 (rank : 178)
Query Neighborhood Hits	1275	Target Neighborhood Hits	799	Shared Neighborhood Hits	769
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

STK4_HUMAN
θ value	5.23862e-24 (rank : 98)	NC score	0.915701 (rank : 149)
Query Neighborhood Hits	1275	Target Neighborhood Hits	870	Shared Neighborhood Hits	825
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

NUAK2_MOUSE
θ value	6.84181e-24 (rank : 99)	NC score	0.915266 (rank : 152)
Query Neighborhood Hits	1275	Target Neighborhood Hits	878	Shared Neighborhood Hits	835
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

CSKP_MOUSE
θ value	8.93572e-24 (rank : 100)	NC score	0.847958 (rank : 513)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1027	Shared Neighborhood Hits	806
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

AURKC_MOUSE
θ value	1.5242e-23 (rank : 101)	NC score	0.919154 (rank : 129)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	828
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

CSKP_HUMAN
θ value	1.5242e-23 (rank : 102)	NC score	0.845396 (rank : 516)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1022	Shared Neighborhood Hits	805
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

DYRK2_HUMAN
θ value	1.5242e-23 (rank : 103)	NC score	0.918510 (rank : 130)
Query Neighborhood Hits	1275	Target Neighborhood Hits	799	Shared Neighborhood Hits	783
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

PAK1_HUMAN
θ value	2.59989e-23 (rank : 104)	NC score	0.916349 (rank : 145)
Query Neighborhood Hits	1275	Target Neighborhood Hits	873	Shared Neighborhood Hits	839
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

STK3_HUMAN
θ value	2.59989e-23 (rank : 105)	NC score	0.914155 (rank : 160)
Query Neighborhood Hits	1275	Target Neighborhood Hits	861	Shared Neighborhood Hits	822
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

SNRK_HUMAN
θ value	3.39556e-23 (rank : 106)	NC score	0.912406 (rank : 165)
Query Neighborhood Hits	1275	Target Neighborhood Hits	855	Shared Neighborhood Hits	815
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

NUAK1_MOUSE
θ value	4.43474e-23 (rank : 107)	NC score	0.916333 (rank : 146)
Query Neighborhood Hits	1275	Target Neighborhood Hits	881	Shared Neighborhood Hits	836
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	4.43474e-23 (rank : 108)	NC score	0.917198 (rank : 137)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	836
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

SNRK_MOUSE
θ value	4.43474e-23 (rank : 109)	NC score	0.913030 (rank : 163)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	814
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

AURKB_MOUSE
θ value	5.79196e-23 (rank : 110)	NC score	0.917440 (rank : 136)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	830
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

DYR1B_HUMAN
θ value	7.56453e-23 (rank : 111)	NC score	0.905656 (rank : 205)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	772
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

STK3_MOUSE
θ value	7.56453e-23 (rank : 112)	NC score	0.914535 (rank : 157)
Query Neighborhood Hits	1275	Target Neighborhood Hits	869	Shared Neighborhood Hits	825
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

NUAK1_HUMAN
θ value	9.87957e-23 (rank : 113)	NC score	0.916427 (rank : 144)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	836
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

PAK1_MOUSE
θ value	9.87957e-23 (rank : 114)	NC score	0.915741 (rank : 148)
Query Neighborhood Hits	1275	Target Neighborhood Hits	878	Shared Neighborhood Hits	840
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

AURKB_HUMAN
θ value	1.6852e-22 (rank : 115)	NC score	0.917664 (rank : 135)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

NEK2_HUMAN
θ value	2.87452e-22 (rank : 116)	NC score	0.925009 (rank : 100)
Query Neighborhood Hits	1275	Target Neighborhood Hits	908	Shared Neighborhood Hits	819
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

HIPK4_HUMAN
θ value	6.40375e-22 (rank : 117)	NC score	0.929970 (rank : 92)
Query Neighborhood Hits	1275	Target Neighborhood Hits	799	Shared Neighborhood Hits	780
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

M3K4_HUMAN
θ value	1.09232e-21 (rank : 118)	NC score	0.923213 (rank : 109)
Query Neighborhood Hits	1275	Target Neighborhood Hits	911	Shared Neighborhood Hits	837
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K6_HUMAN
θ value	1.42661e-21 (rank : 119)	NC score	0.923254 (rank : 108)
Query Neighborhood Hits	1275	Target Neighborhood Hits	889	Shared Neighborhood Hits	843
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

PRP4B_HUMAN
θ value	1.42661e-21 (rank : 120)	NC score	0.906715 (rank : 196)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1030	Shared Neighborhood Hits	822
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	1.42661e-21 (rank : 121)	NC score	0.904654 (rank : 217)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1040	Shared Neighborhood Hits	823
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

TAOK1_HUMAN
θ value	1.42661e-21 (rank : 122)	NC score	0.867934 (rank : 423)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1734	Shared Neighborhood Hits	900
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	1.42661e-21 (rank : 123)	NC score	0.868206 (rank : 422)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1720	Shared Neighborhood Hits	901
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

DCAK3_MOUSE
θ value	1.86321e-21 (rank : 124)	NC score	0.905163 (rank : 211)
Query Neighborhood Hits	1275	Target Neighborhood Hits	922	Shared Neighborhood Hits	837
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

NEK1_MOUSE
θ value	1.86321e-21 (rank : 125)	NC score	0.920912 (rank : 116)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1311	Shared Neighborhood Hits	882
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

SN1L1_MOUSE
θ value	1.86321e-21 (rank : 126)	NC score	0.907384 (rank : 189)
Query Neighborhood Hits	1275	Target Neighborhood Hits	895	Shared Neighborhood Hits	837
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

AURKC_HUMAN
θ value	2.43343e-21 (rank : 127)	NC score	0.920245 (rank : 121)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	829
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

CHK1_HUMAN
θ value	3.17815e-21 (rank : 128)	NC score	0.923070 (rank : 110)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	823
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

NEK2_MOUSE
θ value	3.17815e-21 (rank : 129)	NC score	0.924920 (rank : 101)
Query Neighborhood Hits	1275	Target Neighborhood Hits	876	Shared Neighborhood Hits	813
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

TAOK3_HUMAN
θ value	3.17815e-21 (rank : 130)	NC score	0.879761 (rank : 362)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1494	Shared Neighborhood Hits	877
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

DYR1A_HUMAN
θ value	7.0802e-21 (rank : 131)	NC score	0.895049 (rank : 283)
Query Neighborhood Hits	1275	Target Neighborhood Hits	764	Shared Neighborhood Hits	745
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	7.0802e-21 (rank : 132)	NC score	0.895114 (rank : 282)
Query Neighborhood Hits	1275	Target Neighborhood Hits	762	Shared Neighborhood Hits	745
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

SN1L1_HUMAN
θ value	7.0802e-21 (rank : 133)	NC score	0.903237 (rank : 223)
Query Neighborhood Hits	1275	Target Neighborhood Hits	911	Shared Neighborhood Hits	842
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

TAOK3_MOUSE
θ value	7.0802e-21 (rank : 134)	NC score	0.884106 (rank : 343)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1458	Shared Neighborhood Hits	876
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

CHK1_MOUSE
θ value	9.24701e-21 (rank : 135)	NC score	0.923717 (rank : 107)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	822
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

NEK1_HUMAN
θ value	9.24701e-21 (rank : 136)	NC score	0.921940 (rank : 114)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1129	Shared Neighborhood Hits	861
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

PAK3_HUMAN
θ value	9.24701e-21 (rank : 137)	NC score	0.915219 (rank : 153)
Query Neighborhood Hits	1275	Target Neighborhood Hits	887	Shared Neighborhood Hits	842
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PHKG2_MOUSE
θ value	1.2077e-20 (rank : 138)	NC score	0.903947 (rank : 220)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	826
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

STK33_HUMAN
θ value	1.2077e-20 (rank : 139)	NC score	0.916547 (rank : 143)
Query Neighborhood Hits	1275	Target Neighborhood Hits	879	Shared Neighborhood Hits	827
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

M3K4_MOUSE
θ value	2.06002e-20 (rank : 140)	NC score	0.922589 (rank : 112)
Query Neighborhood Hits	1275	Target Neighborhood Hits	924	Shared Neighborhood Hits	837
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K1_MOUSE
θ value	2.69047e-20 (rank : 141)	NC score	0.929775 (rank : 95)
Query Neighborhood Hits	1275	Target Neighborhood Hits	952	Shared Neighborhood Hits	846
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

PHKG2_HUMAN
θ value	3.51386e-20 (rank : 142)	NC score	0.902365 (rank : 232)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	825
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PLK3_HUMAN
θ value	3.51386e-20 (rank : 143)	NC score	0.915303 (rank : 151)
Query Neighborhood Hits	1275	Target Neighborhood Hits	865	Shared Neighborhood Hits	827
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

TAOK2_HUMAN
θ value	3.51386e-20 (rank : 144)	NC score	0.906514 (rank : 197)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1172	Shared Neighborhood Hits	862
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	3.51386e-20 (rank : 145)	NC score	0.893068 (rank : 302)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1373	Shared Neighborhood Hits	878
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

M3K15_HUMAN
θ value	4.58923e-20 (rank : 146)	NC score	0.922108 (rank : 113)
Query Neighborhood Hits	1275	Target Neighborhood Hits	914	Shared Neighborhood Hits	836
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K2_HUMAN
θ value	4.58923e-20 (rank : 147)	NC score	0.919589 (rank : 126)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MARK4_HUMAN
θ value	4.58923e-20 (rank : 148)	NC score	0.906888 (rank : 194)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	844
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

STK10_MOUSE
θ value	4.58923e-20 (rank : 149)	NC score	0.835446 (rank : 526)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2132	Shared Neighborhood Hits	934
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

HIPK2_HUMAN
θ value	5.99374e-20 (rank : 150)	NC score	0.893734 (rank : 294)
Query Neighborhood Hits	1275	Target Neighborhood Hits	845	Shared Neighborhood Hits	785
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

M4K2_HUMAN
θ value	5.99374e-20 (rank : 151)	NC score	0.898885 (rank : 259)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	5.99374e-20 (rank : 152)	NC score	0.899833 (rank : 250)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	815
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

ULK3_MOUSE
θ value	5.99374e-20 (rank : 153)	NC score	0.925827 (rank : 98)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	826
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

M3K3_MOUSE
θ value	7.82807e-20 (rank : 154)	NC score	0.920078 (rank : 123)
Query Neighborhood Hits	1275	Target Neighborhood Hits	876	Shared Neighborhood Hits	836
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MST4_HUMAN
θ value	7.82807e-20 (rank : 155)	NC score	0.909599 (rank : 179)
Query Neighborhood Hits	1275	Target Neighborhood Hits	852	Shared Neighborhood Hits	827
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

PLK4_MOUSE
θ value	7.82807e-20 (rank : 156)	NC score	0.920351 (rank : 120)
Query Neighborhood Hits	1275	Target Neighborhood Hits	879	Shared Neighborhood Hits	836
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PAK7_HUMAN
θ value	1.02238e-19 (rank : 157)	NC score	0.916706 (rank : 140)
Query Neighborhood Hits	1275	Target Neighborhood Hits	875	Shared Neighborhood Hits	832
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	1.02238e-19 (rank : 158)	NC score	0.916563 (rank : 142)
Query Neighborhood Hits	1275	Target Neighborhood Hits	875	Shared Neighborhood Hits	830
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

M3K3_HUMAN
θ value	1.33526e-19 (rank : 159)	NC score	0.920812 (rank : 117)
Query Neighborhood Hits	1275	Target Neighborhood Hits	885	Shared Neighborhood Hits	840
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MARK2_HUMAN
θ value	1.33526e-19 (rank : 160)	NC score	0.902231 (rank : 233)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1056	Shared Neighborhood Hits	877
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK4_MOUSE
θ value	1.33526e-19 (rank : 161)	NC score	0.906727 (rank : 195)
Query Neighborhood Hits	1275	Target Neighborhood Hits	898	Shared Neighborhood Hits	842
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

PAK2_HUMAN
θ value	1.33526e-19 (rank : 162)	NC score	0.917954 (rank : 133)
Query Neighborhood Hits	1275	Target Neighborhood Hits	862	Shared Neighborhood Hits	835
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

JAK2_HUMAN
θ value	1.74391e-19 (rank : 163)	NC score	0.856340 (rank : 479)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	817
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

M4K1_HUMAN
θ value	1.74391e-19 (rank : 164)	NC score	0.909892 (rank : 176)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	833
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M3K2_MOUSE
θ value	2.97466e-19 (rank : 165)	NC score	0.917062 (rank : 138)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	824
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

E2AK2_HUMAN
θ value	3.88503e-19 (rank : 166)	NC score	0.924647 (rank : 102)
Query Neighborhood Hits	1275	Target Neighborhood Hits	856	Shared Neighborhood Hits	820
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

PAK3_MOUSE
θ value	3.88503e-19 (rank : 167)	NC score	0.915162 (rank : 155)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	834
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PLK4_HUMAN
θ value	3.88503e-19 (rank : 168)	NC score	0.918409 (rank : 131)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	833
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

ULK1_MOUSE
θ value	3.88503e-19 (rank : 169)	NC score	0.919416 (rank : 127)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1214	Shared Neighborhood Hits	892
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

DCAK3_HUMAN
θ value	5.07402e-19 (rank : 170)	NC score	0.905689 (rank : 204)
Query Neighborhood Hits	1275	Target Neighborhood Hits	888	Shared Neighborhood Hits	839
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

M4K3_HUMAN
θ value	5.07402e-19 (rank : 171)	NC score	0.904707 (rank : 216)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	830
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

PAK2_MOUSE
θ value	5.07402e-19 (rank : 172)	NC score	0.917762 (rank : 134)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	832
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

SN1L2_HUMAN
θ value	5.07402e-19 (rank : 173)	NC score	0.900937 (rank : 242)
Query Neighborhood Hits	1275	Target Neighborhood Hits	964	Shared Neighborhood Hits	879
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

ULK3_HUMAN
θ value	5.07402e-19 (rank : 174)	NC score	0.931415 (rank : 89)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	818
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

MARK2_MOUSE
θ value	6.62687e-19 (rank : 175)	NC score	0.900127 (rank : 247)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1018	Shared Neighborhood Hits	873
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

STK10_HUMAN
θ value	6.62687e-19 (rank : 176)	NC score	0.857823 (rank : 470)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1921	Shared Neighborhood Hits	915
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

JAK2_MOUSE
θ value	8.65492e-19 (rank : 177)	NC score	0.853321 (rank : 493)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	813
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

M3K5_HUMAN
θ value	8.65492e-19 (rank : 178)	NC score	0.919678 (rank : 125)
Query Neighborhood Hits	1275	Target Neighborhood Hits	868	Shared Neighborhood Hits	831
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	8.65492e-19 (rank : 179)	NC score	0.919702 (rank : 124)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	832
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

SLK_HUMAN
θ value	8.65492e-19 (rank : 180)	NC score	0.877175 (rank : 368)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1775	Shared Neighborhood Hits	910
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

TLK2_HUMAN
θ value	8.65492e-19 (rank : 181)	NC score	0.892283 (rank : 307)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1044	Shared Neighborhood Hits	797
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	8.65492e-19 (rank : 182)	NC score	0.890032 (rank : 314)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1088	Shared Neighborhood Hits	804
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

ULK1_HUMAN
θ value	8.65492e-19 (rank : 183)	NC score	0.920675 (rank : 118)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1121	Shared Neighborhood Hits	870
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

CHK2_MOUSE
θ value	1.13037e-18 (rank : 184)	NC score	0.906909 (rank : 193)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	825
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

HIPK2_MOUSE
θ value	1.13037e-18 (rank : 185)	NC score	0.893329 (rank : 301)
Query Neighborhood Hits	1275	Target Neighborhood Hits	871	Shared Neighborhood Hits	793
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

MST4_MOUSE
θ value	1.13037e-18 (rank : 186)	NC score	0.909536 (rank : 180)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	828
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

PAK4_MOUSE
θ value	1.13037e-18 (rank : 187)	NC score	0.913838 (rank : 162)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1098	Shared Neighborhood Hits	865
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PLK3_MOUSE
θ value	1.13037e-18 (rank : 188)	NC score	0.914133 (rank : 161)
Query Neighborhood Hits	1275	Target Neighborhood Hits	863	Shared Neighborhood Hits	829
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

K0999_HUMAN
θ value	1.47631e-18 (rank : 189)	NC score	0.893633 (rank : 296)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

TEC_MOUSE
θ value	1.47631e-18 (rank : 190)	NC score	0.806069 (rank : 558)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1006	Shared Neighborhood Hits	813
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

PDPK1_HUMAN
θ value	1.92812e-18 (rank : 191)	NC score	0.902913 (rank : 226)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	830
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	1.92812e-18 (rank : 192)	NC score	0.903063 (rank : 225)
Query Neighborhood Hits	1275	Target Neighborhood Hits	852	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

SN1L2_MOUSE
θ value	1.92812e-18 (rank : 193)	NC score	0.899986 (rank : 249)
Query Neighborhood Hits	1275	Target Neighborhood Hits	944	Shared Neighborhood Hits	867
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

K0999_MOUSE
θ value	2.5182e-18 (rank : 194)	NC score	0.893470 (rank : 298)
Query Neighborhood Hits	1275	Target Neighborhood Hits	931	Shared Neighborhood Hits	842
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KS6A2_HUMAN
θ value	2.5182e-18 (rank : 195)	NC score	0.885786 (rank : 336)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	832
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PAK4_HUMAN
θ value	2.5182e-18 (rank : 196)	NC score	0.914816 (rank : 156)
Query Neighborhood Hits	1275	Target Neighborhood Hits	924	Shared Neighborhood Hits	847
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

KCC2B_HUMAN
θ value	3.28887e-18 (rank : 197)	NC score	0.891703 (rank : 311)
Query Neighborhood Hits	1275	Target Neighborhood Hits	866	Shared Neighborhood Hits	824
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

NEK4_HUMAN
θ value	3.28887e-18 (rank : 198)	NC score	0.920666 (rank : 119)
Query Neighborhood Hits	1275	Target Neighborhood Hits	883	Shared Neighborhood Hits	836
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	3.28887e-18 (rank : 199)	NC score	0.921856 (rank : 115)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	844
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

PAK6_HUMAN
θ value	3.28887e-18 (rank : 200)	NC score	0.916900 (rank : 139)
Query Neighborhood Hits	1275	Target Neighborhood Hits	915	Shared Neighborhood Hits	849
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

STK24_HUMAN
θ value	3.28887e-18 (rank : 201)	NC score	0.910555 (rank : 173)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

CAMKV_HUMAN
θ value	4.29542e-18 (rank : 202)	NC score	0.852866 (rank : 495)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1084	Shared Neighborhood Hits	822
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CLK3_HUMAN
θ value	4.29542e-18 (rank : 203)	NC score	0.856979 (rank : 475)
Query Neighborhood Hits	1275	Target Neighborhood Hits	748	Shared Neighborhood Hits	729
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	4.29542e-18 (rank : 204)	NC score	0.856397 (rank : 478)
Query Neighborhood Hits	1275	Target Neighborhood Hits	761	Shared Neighborhood Hits	731
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

KS6A2_MOUSE
θ value	4.29542e-18 (rank : 205)	NC score	0.886035 (rank : 332)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

STK11_HUMAN
θ value	4.29542e-18 (rank : 206)	NC score	0.925287 (rank : 99)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	822
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

KCC2A_MOUSE
θ value	5.60996e-18 (rank : 207)	NC score	0.891908 (rank : 310)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	810
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

M4K1_MOUSE
θ value	5.60996e-18 (rank : 208)	NC score	0.909806 (rank : 177)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	828
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K5_MOUSE
θ value	5.60996e-18 (rank : 209)	NC score	0.898412 (rank : 261)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	818
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

ST32A_MOUSE
θ value	5.60996e-18 (rank : 210)	NC score	0.893745 (rank : 293)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

HIPK1_HUMAN
θ value	7.32683e-18 (rank : 211)	NC score	0.895852 (rank : 278)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	785
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

KCC4_MOUSE
θ value	7.32683e-18 (rank : 212)	NC score	0.896610 (rank : 273)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	835
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

M4K5_HUMAN
θ value	7.32683e-18 (rank : 213)	NC score	0.897183 (rank : 266)
Query Neighborhood Hits	1275	Target Neighborhood Hits	845	Shared Neighborhood Hits	820
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

NEK7_HUMAN
θ value	7.32683e-18 (rank : 214)	NC score	0.926024 (rank : 97)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	828
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

HIPK1_MOUSE
θ value	9.56915e-18 (rank : 215)	NC score	0.895786 (rank : 279)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	785
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

MYO3A_MOUSE
θ value	9.56915e-18 (rank : 216)	NC score	0.794487 (rank : 586)
Query Neighborhood Hits	1275	Target Neighborhood Hits	902	Shared Neighborhood Hits	821
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

PLK1_MOUSE
θ value	9.56915e-18 (rank : 217)	NC score	0.905859 (rank : 200)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	825
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

STK24_MOUSE
θ value	9.56915e-18 (rank : 218)	NC score	0.910099 (rank : 174)
Query Neighborhood Hits	1275	Target Neighborhood Hits	856	Shared Neighborhood Hits	829
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

TEC_HUMAN
θ value	9.56915e-18 (rank : 219)	NC score	0.801035 (rank : 575)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1006	Shared Neighborhood Hits	813
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CHK2_HUMAN
θ value	1.24977e-17 (rank : 220)	NC score	0.903463 (rank : 222)
Query Neighborhood Hits	1275	Target Neighborhood Hits	859	Shared Neighborhood Hits	824
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

AAPK2_HUMAN
θ value	1.63225e-17 (rank : 221)	NC score	0.901077 (rank : 238)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	822
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

KCC1A_HUMAN
θ value	1.63225e-17 (rank : 222)	NC score	0.901075 (rank : 239)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	826
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

MARK1_HUMAN
θ value	1.63225e-17 (rank : 223)	NC score	0.900370 (rank : 244)
Query Neighborhood Hits	1275	Target Neighborhood Hits	887	Shared Neighborhood Hits	837
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

NEK8_MOUSE
θ value	1.63225e-17 (rank : 224)	NC score	0.910585 (rank : 172)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	825
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

KCC1A_MOUSE
θ value	2.13179e-17 (rank : 225)	NC score	0.901057 (rank : 240)
Query Neighborhood Hits	1275	Target Neighborhood Hits	845	Shared Neighborhood Hits	826
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC2D_HUMAN
θ value	2.13179e-17 (rank : 226)	NC score	0.893508 (rank : 297)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	814
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KS6A1_MOUSE
θ value	2.13179e-17 (rank : 227)	NC score	0.880360 (rank : 360)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	829
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

LIMK1_HUMAN
θ value	2.13179e-17 (rank : 228)	NC score	0.852360 (rank : 497)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1005	Shared Neighborhood Hits	818
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MARK3_MOUSE
θ value	2.13179e-17 (rank : 229)	NC score	0.902822 (rank : 228)
Query Neighborhood Hits	1275	Target Neighborhood Hits	919	Shared Neighborhood Hits	846
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MYO3A_HUMAN
θ value	2.13179e-17 (rank : 230)	NC score	0.785224 (rank : 608)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1033	Shared Neighborhood Hits	845
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

NEK9_HUMAN
θ value	2.13179e-17 (rank : 231)	NC score	0.905086 (rank : 212)
Query Neighborhood Hits	1275	Target Neighborhood Hits	900	Shared Neighborhood Hits	833
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	2.13179e-17 (rank : 232)	NC score	0.905597 (rank : 207)
Query Neighborhood Hits	1275	Target Neighborhood Hits	890	Shared Neighborhood Hits	832
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

DAPK3_HUMAN
θ value	2.7842e-17 (rank : 233)	NC score	0.901159 (rank : 237)
Query Neighborhood Hits	1275	Target Neighborhood Hits	945	Shared Neighborhood Hits	823
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KCC2B_MOUSE
θ value	2.7842e-17 (rank : 234)	NC score	0.889079 (rank : 317)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	813
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KS6A1_HUMAN
θ value	2.7842e-17 (rank : 235)	NC score	0.884813 (rank : 339)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	830
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

NEK8_HUMAN
θ value	2.7842e-17 (rank : 236)	NC score	0.910663 (rank : 170)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	826
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

KCC2A_HUMAN
θ value	4.74913e-17 (rank : 237)	NC score	0.893019 (rank : 303)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	812
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KS6A4_HUMAN
θ value	4.74913e-17 (rank : 238)	NC score	0.868257 (rank : 421)
Query Neighborhood Hits	1275	Target Neighborhood Hits	868	Shared Neighborhood Hits	837
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A5_MOUSE
θ value	4.74913e-17 (rank : 239)	NC score	0.864990 (rank : 436)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	826
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MARK1_MOUSE
θ value	4.74913e-17 (rank : 240)	NC score	0.900323 (rank : 245)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	840
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

SLK_MOUSE
θ value	4.74913e-17 (rank : 241)	NC score	0.879512 (rank : 363)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1798	Shared Neighborhood Hits	911
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

AAPK1_HUMAN
θ value	6.20254e-17 (rank : 242)	NC score	0.905851 (rank : 201)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	822
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

BRSK1_HUMAN
θ value	6.20254e-17 (rank : 243)	NC score	0.907381 (rank : 190)
Query Neighborhood Hits	1275	Target Neighborhood Hits	942	Shared Neighborhood Hits	852
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

E2AK2_MOUSE
θ value	6.20254e-17 (rank : 244)	NC score	0.931064 (rank : 90)
Query Neighborhood Hits	1275	Target Neighborhood Hits	864	Shared Neighborhood Hits	827
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

KS6A6_HUMAN
θ value	6.20254e-17 (rank : 245)	NC score	0.883137 (rank : 349)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	830
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

LIMK1_MOUSE
θ value	6.20254e-17 (rank : 246)	NC score	0.852234 (rank : 499)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1008	Shared Neighborhood Hits	816
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

AKT3_HUMAN
θ value	8.10077e-17 (rank : 247)	NC score	0.869512 (rank : 413)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	820
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	8.10077e-17 (rank : 248)	NC score	0.869468 (rank : 414)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	820
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

KCC1D_MOUSE
θ value	8.10077e-17 (rank : 249)	NC score	0.893455 (rank : 299)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	821
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KS6A5_HUMAN
θ value	8.10077e-17 (rank : 250)	NC score	0.874744 (rank : 378)
Query Neighborhood Hits	1275	Target Neighborhood Hits	855	Shared Neighborhood Hits	826
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

RK_MOUSE
θ value	8.10077e-17 (rank : 251)	NC score	0.868762 (rank : 418)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	813
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ST32A_HUMAN
θ value	8.10077e-17 (rank : 252)	NC score	0.889868 (rank : 315)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	822
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

STK25_HUMAN
θ value	8.10077e-17 (rank : 253)	NC score	0.908682 (rank : 181)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	828
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

ULK2_MOUSE
θ value	8.10077e-17 (rank : 254)	NC score	0.923848 (rank : 106)
Query Neighborhood Hits	1275	Target Neighborhood Hits	943	Shared Neighborhood Hits	851
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

NEK7_MOUSE
θ value	1.058e-16 (rank : 255)	NC score	0.926055 (rank : 96)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	829
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

MYLK_MOUSE
θ value	1.38178e-16 (rank : 256)	NC score	0.822019 (rank : 545)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1489	Shared Neighborhood Hits	883
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PLK2_HUMAN
θ value	1.38178e-16 (rank : 257)	NC score	0.907454 (rank : 188)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	830
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	1.38178e-16 (rank : 258)	NC score	0.907345 (rank : 191)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	828
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

SPEG_HUMAN
θ value	1.38178e-16 (rank : 259)	NC score	0.824536 (rank : 539)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1762	Shared Neighborhood Hits	967
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STK25_MOUSE
θ value	1.38178e-16 (rank : 260)	NC score	0.908213 (rank : 185)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	827
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

TYK2_HUMAN
θ value	1.38178e-16 (rank : 261)	NC score	0.841807 (rank : 519)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	818
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

FYN_HUMAN
θ value	1.80466e-16 (rank : 262)	NC score	0.791540 (rank : 596)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1078	Shared Neighborhood Hits	827
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

KCC1D_HUMAN
θ value	1.80466e-16 (rank : 263)	NC score	0.893422 (rank : 300)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	821
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KPCL_MOUSE
θ value	1.80466e-16 (rank : 264)	NC score	0.853689 (rank : 492)
Query Neighborhood Hits	1275	Target Neighborhood Hits	891	Shared Neighborhood Hits	815
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

TSSK1_MOUSE
θ value	1.80466e-16 (rank : 265)	NC score	0.899390 (rank : 253)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	815
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

ULK2_HUMAN
θ value	1.80466e-16 (rank : 266)	NC score	0.922610 (rank : 111)
Query Neighborhood Hits	1275	Target Neighborhood Hits	979	Shared Neighborhood Hits	847
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

AAPK1_MOUSE
θ value	2.35696e-16 (rank : 267)	NC score	0.905313 (rank : 210)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	822
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

CLK2_MOUSE
θ value	2.35696e-16 (rank : 268)	NC score	0.852853 (rank : 496)
Query Neighborhood Hits	1275	Target Neighborhood Hits	743	Shared Neighborhood Hits	727
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

HIPK3_HUMAN
θ value	2.35696e-16 (rank : 269)	NC score	0.897372 (rank : 265)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	792
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

KPSH1_MOUSE
θ value	2.35696e-16 (rank : 270)	NC score	0.896108 (rank : 276)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	819
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KS6B1_HUMAN
θ value	2.35696e-16 (rank : 271)	NC score	0.883448 (rank : 346)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	823
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	2.35696e-16 (rank : 272)	NC score	0.883487 (rank : 345)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	823
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

TSSK1_HUMAN
θ value	2.35696e-16 (rank : 273)	NC score	0.886017 (rank : 333)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	806
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

CLK1_MOUSE
θ value	3.07829e-16 (rank : 274)	NC score	0.873967 (rank : 382)
Query Neighborhood Hits	1275	Target Neighborhood Hits	760	Shared Neighborhood Hits	743
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK2_HUMAN
θ value	3.07829e-16 (rank : 275)	NC score	0.862475 (rank : 453)
Query Neighborhood Hits	1275	Target Neighborhood Hits	752	Shared Neighborhood Hits	733
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

HIPK3_MOUSE
θ value	3.07829e-16 (rank : 276)	NC score	0.898935 (rank : 257)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	795
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

KCC1G_MOUSE
θ value	3.07829e-16 (rank : 277)	NC score	0.899192 (rank : 256)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	826
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

PLK1_HUMAN
θ value	3.07829e-16 (rank : 278)	NC score	0.905045 (rank : 214)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	824
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

CLK1_HUMAN
θ value	4.02038e-16 (rank : 279)	NC score	0.871601 (rank : 396)
Query Neighborhood Hits	1275	Target Neighborhood Hits	756	Shared Neighborhood Hits	735
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

CLK4_MOUSE
θ value	4.02038e-16 (rank : 280)	NC score	0.869122 (rank : 415)
Query Neighborhood Hits	1275	Target Neighborhood Hits	759	Shared Neighborhood Hits	746
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

KCC1G_HUMAN
θ value	4.02038e-16 (rank : 281)	NC score	0.898634 (rank : 260)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	823
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2G_HUMAN
θ value	4.02038e-16 (rank : 282)	NC score	0.894400 (rank : 285)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	819
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	4.02038e-16 (rank : 283)	NC score	0.894333 (rank : 288)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	818
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KS6A4_MOUSE
θ value	4.02038e-16 (rank : 284)	NC score	0.869832 (rank : 409)
Query Neighborhood Hits	1275	Target Neighborhood Hits	866	Shared Neighborhood Hits	835
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

NEK6_MOUSE
θ value	4.02038e-16 (rank : 285)	NC score	0.929855 (rank : 94)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	829
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

ST32B_MOUSE
θ value	4.02038e-16 (rank : 286)	NC score	0.886875 (rank : 331)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	814
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

YES_HUMAN
θ value	4.02038e-16 (rank : 287)	NC score	0.780980 (rank : 616)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1059	Shared Neighborhood Hits	820
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CAMKV_MOUSE
θ value	5.25075e-16 (rank : 288)	NC score	0.857736 (rank : 471)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	785
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CSK_MOUSE
θ value	5.25075e-16 (rank : 289)	NC score	0.809720 (rank : 555)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	822
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

FES_HUMAN
θ value	5.25075e-16 (rank : 290)	NC score	0.823359 (rank : 542)
Query Neighborhood Hits	1275	Target Neighborhood Hits	978	Shared Neighborhood Hits	812
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

GRK6_HUMAN
θ value	5.25075e-16 (rank : 291)	NC score	0.873878 (rank : 383)
Query Neighborhood Hits	1275	Target Neighborhood Hits	823	Shared Neighborhood Hits	809
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	5.25075e-16 (rank : 292)	NC score	0.872954 (rank : 388)
Query Neighborhood Hits	1275	Target Neighborhood Hits	820	Shared Neighborhood Hits	810
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KAPCA_HUMAN
θ value	5.25075e-16 (rank : 293)	NC score	0.875636 (rank : 372)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KPCL_HUMAN
θ value	5.25075e-16 (rank : 294)	NC score	0.849943 (rank : 505)
Query Neighborhood Hits	1275	Target Neighborhood Hits	887	Shared Neighborhood Hits	815
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KS6A3_HUMAN
θ value	5.25075e-16 (rank : 295)	NC score	0.881995 (rank : 353)
Query Neighborhood Hits	1275	Target Neighborhood Hits	859	Shared Neighborhood Hits	832
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	5.25075e-16 (rank : 296)	NC score	0.882012 (rank : 352)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	832
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

M4K4_HUMAN
θ value	5.25075e-16 (rank : 297)	NC score	0.873395 (rank : 387)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1589	Shared Neighborhood Hits	895
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

SRC_MOUSE
θ value	5.25075e-16 (rank : 298)	NC score	0.785689 (rank : 607)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1033	Shared Neighborhood Hits	818
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

YES_MOUSE
θ value	5.25075e-16 (rank : 299)	NC score	0.780313 (rank : 618)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1052	Shared Neighborhood Hits	818
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

DAPK3_MOUSE
θ value	6.85773e-16 (rank : 300)	NC score	0.900076 (rank : 248)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	814
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

FGR_HUMAN
θ value	6.85773e-16 (rank : 301)	NC score	0.776591 (rank : 619)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1067	Shared Neighborhood Hits	825
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

HUNK_HUMAN
θ value	6.85773e-16 (rank : 302)	NC score	0.905317 (rank : 209)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	834
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

KAPCA_MOUSE
θ value	6.85773e-16 (rank : 303)	NC score	0.874898 (rank : 376)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	824
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KPSH1_HUMAN
θ value	6.85773e-16 (rank : 304)	NC score	0.896183 (rank : 275)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	820
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

NEK6_HUMAN
θ value	6.85773e-16 (rank : 305)	NC score	0.929884 (rank : 93)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	829
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

SRC_HUMAN
θ value	6.85773e-16 (rank : 306)	NC score	0.783858 (rank : 612)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1058	Shared Neighborhood Hits	820
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ST32C_MOUSE
θ value	6.85773e-16 (rank : 307)	NC score	0.888754 (rank : 319)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	812
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

TSSK3_MOUSE
θ value	6.85773e-16 (rank : 308)	NC score	0.888671 (rank : 320)
Query Neighborhood Hits	1275	Target Neighborhood Hits	806	Shared Neighborhood Hits	791
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

AKT2_MOUSE
θ value	8.95645e-16 (rank : 309)	NC score	0.866071 (rank : 432)
Query Neighborhood Hits	1275	Target Neighborhood Hits	875	Shared Neighborhood Hits	818
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

FGR_MOUSE
θ value	8.95645e-16 (rank : 310)	NC score	0.774534 (rank : 624)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1069	Shared Neighborhood Hits	822
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

KPCD1_MOUSE
θ value	8.95645e-16 (rank : 311)	NC score	0.900621 (rank : 243)
Query Neighborhood Hits	1275	Target Neighborhood Hits	891	Shared Neighborhood Hits	821
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

CLK4_HUMAN
θ value	1.16975e-15 (rank : 312)	NC score	0.869981 (rank : 407)
Query Neighborhood Hits	1275	Target Neighborhood Hits	759	Shared Neighborhood Hits	747
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CSK_HUMAN
θ value	1.16975e-15 (rank : 313)	NC score	0.801807 (rank : 566)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	821
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

KCC4_HUMAN
θ value	1.16975e-15 (rank : 314)	NC score	0.895861 (rank : 277)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	824
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

NEK11_MOUSE
θ value	1.16975e-15 (rank : 315)	NC score	0.917985 (rank : 132)
Query Neighborhood Hits	1275	Target Neighborhood Hits	875	Shared Neighborhood Hits	825
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

ST32C_HUMAN
θ value	1.16975e-15 (rank : 316)	NC score	0.885309 (rank : 338)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	815
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

FES_MOUSE
θ value	1.52774e-15 (rank : 317)	NC score	0.823437 (rank : 541)
Query Neighborhood Hits	1275	Target Neighborhood Hits	980	Shared Neighborhood Hits	820
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FYN_MOUSE
θ value	1.52774e-15 (rank : 318)	NC score	0.783972 (rank : 611)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1073	Shared Neighborhood Hits	828
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

MYO3B_HUMAN
θ value	1.52774e-15 (rank : 319)	NC score	0.780550 (rank : 617)
Query Neighborhood Hits	1275	Target Neighborhood Hits	923	Shared Neighborhood Hits	832
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

PTK6_MOUSE
θ value	1.52774e-15 (rank : 320)	NC score	0.821129 (rank : 548)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1026	Shared Neighborhood Hits	822
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

AKT2_HUMAN
θ value	1.99529e-15 (rank : 321)	NC score	0.866472 (rank : 426)
Query Neighborhood Hits	1275	Target Neighborhood Hits	878	Shared Neighborhood Hits	818
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

BRSK2_HUMAN
θ value	1.99529e-15 (rank : 322)	NC score	0.905617 (rank : 206)
Query Neighborhood Hits	1275	Target Neighborhood Hits	897	Shared Neighborhood Hits	835
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

GRK4_MOUSE
θ value	1.99529e-15 (rank : 323)	NC score	0.863220 (rank : 447)
Query Neighborhood Hits	1275	Target Neighborhood Hits	808	Shared Neighborhood Hits	797
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

KAPCG_HUMAN
θ value	1.99529e-15 (rank : 324)	NC score	0.880785 (rank : 357)
Query Neighborhood Hits	1275	Target Neighborhood Hits	845	Shared Neighborhood Hits	827
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KPCD1_HUMAN
θ value	1.99529e-15 (rank : 325)	NC score	0.901026 (rank : 241)
Query Neighborhood Hits	1275	Target Neighborhood Hits	901	Shared Neighborhood Hits	822
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

M3K13_HUMAN
θ value	1.99529e-15 (rank : 326)	NC score	0.881430 (rank : 354)
Query Neighborhood Hits	1275	Target Neighborhood Hits	911	Shared Neighborhood Hits	833
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

ST17B_MOUSE
θ value	1.99529e-15 (rank : 327)	NC score	0.905464 (rank : 208)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	816
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

TLK1_HUMAN
θ value	1.99529e-15 (rank : 328)	NC score	0.888045 (rank : 325)
Query Neighborhood Hits	1275	Target Neighborhood Hits	967	Shared Neighborhood Hits	781
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	1.99529e-15 (rank : 329)	NC score	0.888182 (rank : 324)
Query Neighborhood Hits	1275	Target Neighborhood Hits	947	Shared Neighborhood Hits	783
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TSSK2_HUMAN
θ value	1.99529e-15 (rank : 330)	NC score	0.892656 (rank : 305)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	810
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

ABL1_HUMAN
θ value	2.60593e-15 (rank : 331)	NC score	0.799308 (rank : 579)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1220	Shared Neighborhood Hits	866
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

EPHB1_HUMAN
θ value	2.60593e-15 (rank : 332)	NC score	0.767004 (rank : 636)
Query Neighborhood Hits	1275	Target Neighborhood Hits	988	Shared Neighborhood Hits	802
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

HUNK_MOUSE
θ value	2.60593e-15 (rank : 333)	NC score	0.905052 (rank : 213)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	835
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

KKCC1_HUMAN
θ value	2.60593e-15 (rank : 334)	NC score	0.902811 (rank : 229)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	825
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MARK3_HUMAN
θ value	2.60593e-15 (rank : 335)	NC score	0.894542 (rank : 284)
Query Neighborhood Hits	1275	Target Neighborhood Hits	893	Shared Neighborhood Hits	834
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MINK1_HUMAN
θ value	2.60593e-15 (rank : 336)	NC score	0.888327 (rank : 322)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1477	Shared Neighborhood Hits	911
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

TYK2_MOUSE
θ value	2.60593e-15 (rank : 337)	NC score	0.839400 (rank : 521)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	817
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

FER_HUMAN
θ value	3.40345e-15 (rank : 338)	NC score	0.801045 (rank : 574)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1278	Shared Neighborhood Hits	829
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

IRAK4_HUMAN
θ value	3.40345e-15 (rank : 339)	NC score	0.883090 (rank : 350)
Query Neighborhood Hits	1275	Target Neighborhood Hits	816	Shared Neighborhood Hits	803
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

KPCD2_HUMAN
θ value	3.40345e-15 (rank : 340)	NC score	0.904873 (rank : 215)
Query Neighborhood Hits	1275	Target Neighborhood Hits	910	Shared Neighborhood Hits	828
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPSH2_HUMAN
θ value	3.40345e-15 (rank : 341)	NC score	0.893799 (rank : 292)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	807
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

MELK_MOUSE
θ value	3.40345e-15 (rank : 342)	NC score	0.899266 (rank : 254)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	825
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MINK1_MOUSE
θ value	3.40345e-15 (rank : 343)	NC score	0.888283 (rank : 323)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1451	Shared Neighborhood Hits	906
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MYLK_HUMAN
θ value	3.40345e-15 (rank : 344)	NC score	0.821584 (rank : 546)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1328	Shared Neighborhood Hits	850
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

STK39_HUMAN
θ value	3.40345e-15 (rank : 345)	NC score	0.905706 (rank : 203)
Query Neighborhood Hits	1275	Target Neighborhood Hits	882	Shared Neighborhood Hits	832
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	3.40345e-15 (rank : 346)	NC score	0.905999 (rank : 199)
Query Neighborhood Hits	1275	Target Neighborhood Hits	915	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

ABL1_MOUSE
θ value	4.44505e-15 (rank : 347)	NC score	0.801345 (rank : 572)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1178	Shared Neighborhood Hits	882
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BTK_MOUSE
θ value	4.44505e-15 (rank : 348)	NC score	0.794279 (rank : 588)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1017	Shared Neighborhood Hits	817
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

EPHA2_MOUSE
θ value	4.44505e-15 (rank : 349)	NC score	0.755778 (rank : 664)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1020	Shared Neighborhood Hits	808
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

TNIK_HUMAN
θ value	4.44505e-15 (rank : 350)	NC score	0.883189 (rank : 348)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1570	Shared Neighborhood Hits	908
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

GRK5_HUMAN
θ value	5.8054e-15 (rank : 351)	NC score	0.870706 (rank : 403)
Query Neighborhood Hits	1275	Target Neighborhood Hits	819	Shared Neighborhood Hits	804
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	5.8054e-15 (rank : 352)	NC score	0.871009 (rank : 401)
Query Neighborhood Hits	1275	Target Neighborhood Hits	823	Shared Neighborhood Hits	804
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

JAK1_HUMAN
θ value	5.8054e-15 (rank : 353)	NC score	0.838661 (rank : 523)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	820
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

KKCC2_HUMAN
θ value	5.8054e-15 (rank : 354)	NC score	0.907678 (rank : 187)
Query Neighborhood Hits	1275	Target Neighborhood Hits	852	Shared Neighborhood Hits	819
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	5.8054e-15 (rank : 355)	NC score	0.907906 (rank : 186)
Query Neighborhood Hits	1275	Target Neighborhood Hits	855	Shared Neighborhood Hits	821
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

MRCKG_HUMAN
θ value	5.8054e-15 (rank : 356)	NC score	0.805761 (rank : 559)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1519	Shared Neighborhood Hits	877
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PHKG1_MOUSE
θ value	5.8054e-15 (rank : 357)	NC score	0.893974 (rank : 291)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	820
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

ST17A_HUMAN
θ value	5.8054e-15 (rank : 358)	NC score	0.899589 (rank : 251)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	809
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST32B_HUMAN
θ value	5.8054e-15 (rank : 359)	NC score	0.884580 (rank : 342)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	816
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

TSSK3_HUMAN
θ value	5.8054e-15 (rank : 360)	NC score	0.887769 (rank : 330)
Query Neighborhood Hits	1275	Target Neighborhood Hits	806	Shared Neighborhood Hits	791
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

EPHA2_HUMAN
θ value	7.58209e-15 (rank : 361)	NC score	0.756187 (rank : 659)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1021	Shared Neighborhood Hits	810
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

AKT1_MOUSE
θ value	9.90251e-15 (rank : 362)	NC score	0.860126 (rank : 464)
Query Neighborhood Hits	1275	Target Neighborhood Hits	878	Shared Neighborhood Hits	817
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

BTK_HUMAN
θ value	9.90251e-15 (rank : 363)	NC score	0.794356 (rank : 587)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1026	Shared Neighborhood Hits	815
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

DAPK2_HUMAN
θ value	9.90251e-15 (rank : 364)	NC score	0.896921 (rank : 269)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	812
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DMPK_HUMAN
θ value	9.90251e-15 (rank : 365)	NC score	0.832935 (rank : 532)
Query Neighborhood Hits	1275	Target Neighborhood Hits	944	Shared Neighborhood Hits	818
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

KPCE_HUMAN
θ value	9.90251e-15 (rank : 366)	NC score	0.855203 (rank : 488)
Query Neighborhood Hits	1275	Target Neighborhood Hits	906	Shared Neighborhood Hits	818
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MAST2_HUMAN
θ value	9.90251e-15 (rank : 367)	NC score	0.862284 (rank : 454)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1189	Shared Neighborhood Hits	895
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

SPEG_MOUSE
θ value	9.90251e-15 (rank : 368)	NC score	0.815611 (rank : 550)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1959	Shared Neighborhood Hits	996
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

KPCA_MOUSE
θ value	1.29331e-14 (rank : 369)	NC score	0.838739 (rank : 522)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1067	Shared Neighborhood Hits	817
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

PASK_MOUSE
θ value	1.29331e-14 (rank : 370)	NC score	0.908320 (rank : 183)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	822
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

LCK_HUMAN
θ value	1.68911e-14 (rank : 371)	NC score	0.792352 (rank : 594)
Query Neighborhood Hits	1275	Target Neighborhood Hits	987	Shared Neighborhood Hits	819
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

MRCKB_HUMAN
θ value	1.68911e-14 (rank : 372)	NC score	0.736114 (rank : 707)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2239	Shared Neighborhood Hits	905
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

RK_HUMAN
θ value	1.68911e-14 (rank : 373)	NC score	0.864859 (rank : 438)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	814
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

DMPK_MOUSE
θ value	2.20605e-14 (rank : 374)	NC score	0.833082 (rank : 531)
Query Neighborhood Hits	1275	Target Neighborhood Hits	908	Shared Neighborhood Hits	815
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

JAK3_MOUSE
θ value	2.20605e-14 (rank : 375)	NC score	0.850427 (rank : 503)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	802
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KPCD3_MOUSE
θ value	2.20605e-14 (rank : 376)	NC score	0.897472 (rank : 263)
Query Neighborhood Hits	1275	Target Neighborhood Hits	901	Shared Neighborhood Hits	821
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KS6B2_HUMAN
θ value	2.20605e-14 (rank : 377)	NC score	0.876629 (rank : 370)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	832
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

MAST3_HUMAN
θ value	2.20605e-14 (rank : 378)	NC score	0.863048 (rank : 449)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1128	Shared Neighborhood Hits	902
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

NEK11_HUMAN
θ value	2.20605e-14 (rank : 379)	NC score	0.916634 (rank : 141)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1043	Shared Neighborhood Hits	843
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PHKG1_HUMAN
θ value	2.20605e-14 (rank : 380)	NC score	0.894147 (rank : 289)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	821
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

TSSK2_MOUSE
θ value	2.20605e-14 (rank : 381)	NC score	0.880936 (rank : 355)
Query Neighborhood Hits	1275	Target Neighborhood Hits	819	Shared Neighborhood Hits	805
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TXK_HUMAN
θ value	2.20605e-14 (rank : 382)	NC score	0.801503 (rank : 569)
Query Neighborhood Hits	1275	Target Neighborhood Hits	971	Shared Neighborhood Hits	809
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ABL2_HUMAN
θ value	2.88119e-14 (rank : 383)	NC score	0.794038 (rank : 589)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1045	Shared Neighborhood Hits	823
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

CTRO_HUMAN
θ value	2.88119e-14 (rank : 384)	NC score	0.761554 (rank : 644)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2092	Shared Neighborhood Hits	902
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

EPHB3_HUMAN
θ value	2.88119e-14 (rank : 385)	NC score	0.745308 (rank : 687)
Query Neighborhood Hits	1275	Target Neighborhood Hits	996	Shared Neighborhood Hits	804
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

IRAK4_MOUSE
θ value	2.88119e-14 (rank : 386)	NC score	0.884697 (rank : 341)
Query Neighborhood Hits	1275	Target Neighborhood Hits	820	Shared Neighborhood Hits	803
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

LIMK2_MOUSE
θ value	2.88119e-14 (rank : 387)	NC score	0.846302 (rank : 515)
Query Neighborhood Hits	1275	Target Neighborhood Hits	998	Shared Neighborhood Hits	808
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MAST2_MOUSE
θ value	2.88119e-14 (rank : 388)	NC score	0.862936 (rank : 450)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1110	Shared Neighborhood Hits	870
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

NTRK2_HUMAN
θ value	2.88119e-14 (rank : 389)	NC score	0.769887 (rank : 630)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1081	Shared Neighborhood Hits	799
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	2.88119e-14 (rank : 390)	NC score	0.769450 (rank : 632)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1088	Shared Neighborhood Hits	799
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

BLK_HUMAN
θ value	3.76295e-14 (rank : 391)	NC score	0.792964 (rank : 593)
Query Neighborhood Hits	1275	Target Neighborhood Hits	994	Shared Neighborhood Hits	824
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

DAPK2_MOUSE
θ value	3.76295e-14 (rank : 392)	NC score	0.898024 (rank : 262)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	816
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

KPCT_HUMAN
θ value	3.76295e-14 (rank : 393)	NC score	0.871954 (rank : 394)
Query Neighborhood Hits	1275	Target Neighborhood Hits	897	Shared Neighborhood Hits	824
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

LCK_MOUSE
θ value	3.76295e-14 (rank : 394)	NC score	0.795938 (rank : 585)
Query Neighborhood Hits	1275	Target Neighborhood Hits	981	Shared Neighborhood Hits	818
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MAST1_HUMAN
θ value	3.76295e-14 (rank : 395)	NC score	0.857070 (rank : 474)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1146	Shared Neighborhood Hits	877
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	3.76295e-14 (rank : 396)	NC score	0.856060 (rank : 481)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1123	Shared Neighborhood Hits	865
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MRCKB_MOUSE
θ value	3.76295e-14 (rank : 397)	NC score	0.743080 (rank : 691)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2180	Shared Neighborhood Hits	899
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

ROR1_MOUSE
θ value	3.76295e-14 (rank : 398)	NC score	0.756134 (rank : 661)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1025	Shared Neighborhood Hits	805
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

KPCD3_HUMAN
θ value	4.91457e-14 (rank : 399)	NC score	0.897118 (rank : 268)
Query Neighborhood Hits	1275	Target Neighborhood Hits	895	Shared Neighborhood Hits	821
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

PTK6_HUMAN
θ value	4.91457e-14 (rank : 400)	NC score	0.825980 (rank : 537)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1020	Shared Neighborhood Hits	821
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

YSK4_HUMAN
θ value	4.91457e-14 (rank : 401)	NC score	0.914286 (rank : 159)
Query Neighborhood Hits	1275	Target Neighborhood Hits	921	Shared Neighborhood Hits	838
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

DAPK1_MOUSE
θ value	6.41864e-14 (rank : 402)	NC score	0.806859 (rank : 557)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1138	Shared Neighborhood Hits	828
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DDR2_HUMAN
θ value	6.41864e-14 (rank : 403)	NC score	0.759020 (rank : 650)
Query Neighborhood Hits	1275	Target Neighborhood Hits	818	Shared Neighborhood Hits	770
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA5_HUMAN
θ value	6.41864e-14 (rank : 404)	NC score	0.756955 (rank : 656)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	804
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

JAK3_HUMAN
θ value	6.41864e-14 (rank : 405)	NC score	0.842574 (rank : 518)
Query Neighborhood Hits	1275	Target Neighborhood Hits	827	Shared Neighborhood Hits	811
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

KKCC1_MOUSE
θ value	6.41864e-14 (rank : 406)	NC score	0.902862 (rank : 227)
Query Neighborhood Hits	1275	Target Neighborhood Hits	866	Shared Neighborhood Hits	825
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KPCA_HUMAN
θ value	6.41864e-14 (rank : 407)	NC score	0.835965 (rank : 525)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1070	Shared Neighborhood Hits	820
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCE_MOUSE
θ value	6.41864e-14 (rank : 408)	NC score	0.855435 (rank : 485)
Query Neighborhood Hits	1275	Target Neighborhood Hits	906	Shared Neighborhood Hits	817
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

DAPK1_HUMAN
θ value	8.38298e-14 (rank : 409)	NC score	0.810856 (rank : 554)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1130	Shared Neighborhood Hits	828
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

EPHB3_MOUSE
θ value	8.38298e-14 (rank : 410)	NC score	0.744005 (rank : 689)
Query Neighborhood Hits	1275	Target Neighborhood Hits	996	Shared Neighborhood Hits	804
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

MAST4_HUMAN
θ value	8.38298e-14 (rank : 411)	NC score	0.852106 (rank : 501)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1804	Shared Neighborhood Hits	983
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MATK_MOUSE
θ value	8.38298e-14 (rank : 412)	NC score	0.802947 (rank : 561)
Query Neighborhood Hits	1275	Target Neighborhood Hits	952	Shared Neighborhood Hits	817
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MRCKA_HUMAN
θ value	8.38298e-14 (rank : 413)	NC score	0.757196 (rank : 655)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1999	Shared Neighborhood Hits	888
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

EPHA4_HUMAN
θ value	1.09485e-13 (rank : 414)	NC score	0.747295 (rank : 681)
Query Neighborhood Hits	1275	Target Neighborhood Hits	975	Shared Neighborhood Hits	802
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	1.09485e-13 (rank : 415)	NC score	0.747031 (rank : 682)
Query Neighborhood Hits	1275	Target Neighborhood Hits	982	Shared Neighborhood Hits	802
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

GRK4_HUMAN
θ value	1.09485e-13 (rank : 416)	NC score	0.865412 (rank : 434)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	804
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

JAK1_MOUSE
θ value	1.09485e-13 (rank : 417)	NC score	0.835002 (rank : 527)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	816
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

KPCI_MOUSE
θ value	1.09485e-13 (rank : 418)	NC score	0.855584 (rank : 482)
Query Neighborhood Hits	1275	Target Neighborhood Hits	888	Shared Neighborhood Hits	828
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCT_MOUSE
θ value	1.09485e-13 (rank : 419)	NC score	0.869713 (rank : 411)
Query Neighborhood Hits	1275	Target Neighborhood Hits	895	Shared Neighborhood Hits	821
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MRCKG_MOUSE
θ value	1.09485e-13 (rank : 420)	NC score	0.803364 (rank : 560)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1466	Shared Neighborhood Hits	860
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

NTRK1_HUMAN
θ value	1.09485e-13 (rank : 421)	NC score	0.746751 (rank : 685)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1023	Shared Neighborhood Hits	783
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

ROR1_HUMAN
θ value	1.09485e-13 (rank : 422)	NC score	0.755650 (rank : 665)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1018	Shared Neighborhood Hits	802
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

AKT1_HUMAN
θ value	1.42992e-13 (rank : 423)	NC score	0.859626 (rank : 465)
Query Neighborhood Hits	1275	Target Neighborhood Hits	885	Shared Neighborhood Hits	818
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

BMP2K_MOUSE
θ value	1.42992e-13 (rank : 424)	NC score	0.862627 (rank : 452)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	783
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CTRO_MOUSE
θ value	1.42992e-13 (rank : 425)	NC score	0.741359 (rank : 697)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2344	Shared Neighborhood Hits	919
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

EPHA3_HUMAN
θ value	1.42992e-13 (rank : 426)	NC score	0.760139 (rank : 648)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1005	Shared Neighborhood Hits	810
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA6_MOUSE
θ value	1.42992e-13 (rank : 427)	NC score	0.709294 (rank : 763)
Query Neighborhood Hits	1275	Target Neighborhood Hits	946	Shared Neighborhood Hits	792
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

M4K4_MOUSE
θ value	1.42992e-13 (rank : 428)	NC score	0.868303 (rank : 420)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1560	Shared Neighborhood Hits	900
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MP2K2_MOUSE
θ value	1.42992e-13 (rank : 429)	NC score	0.911413 (rank : 167)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	814
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

OXSR1_HUMAN
θ value	1.42992e-13 (rank : 430)	NC score	0.904377 (rank : 218)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	835
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

SGK2_MOUSE
θ value	1.42992e-13 (rank : 431)	NC score	0.869966 (rank : 408)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	820
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ULK4_MOUSE
θ value	1.42992e-13 (rank : 432)	NC score	0.892795 (rank : 304)
Query Neighborhood Hits	1275	Target Neighborhood Hits	793	Shared Neighborhood Hits	766
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

EPHA3_MOUSE
θ value	1.86753e-13 (rank : 433)	NC score	0.754521 (rank : 669)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	816
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

KAPCB_MOUSE
θ value	1.86753e-13 (rank : 434)	NC score	0.871900 (rank : 395)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	823
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

MYLK2_HUMAN
θ value	1.86753e-13 (rank : 435)	NC score	0.901607 (rank : 236)
Query Neighborhood Hits	1275	Target Neighborhood Hits	920	Shared Neighborhood Hits	830
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

OXSR1_MOUSE
θ value	1.86753e-13 (rank : 436)	NC score	0.904172 (rank : 219)
Query Neighborhood Hits	1275	Target Neighborhood Hits	865	Shared Neighborhood Hits	833
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ARBK1_HUMAN
θ value	2.43908e-13 (rank : 437)	NC score	0.858173 (rank : 469)
Query Neighborhood Hits	1275	Target Neighborhood Hits	859	Shared Neighborhood Hits	814
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	2.43908e-13 (rank : 438)	NC score	0.855339 (rank : 487)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	814
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

BLK_MOUSE
θ value	2.43908e-13 (rank : 439)	NC score	0.788248 (rank : 602)
Query Neighborhood Hits	1275	Target Neighborhood Hits	992	Shared Neighborhood Hits	820
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

KAPCB_HUMAN
θ value	2.43908e-13 (rank : 440)	NC score	0.872432 (rank : 391)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KPCG_MOUSE
θ value	2.43908e-13 (rank : 441)	NC score	0.826610 (rank : 534)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1123	Shared Neighborhood Hits	817
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

ST38L_HUMAN
θ value	2.43908e-13 (rank : 442)	NC score	0.833492 (rank : 528)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	789
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

DDR2_MOUSE
θ value	3.18553e-13 (rank : 443)	NC score	0.762320 (rank : 643)
Query Neighborhood Hits	1275	Target Neighborhood Hits	813	Shared Neighborhood Hits	771
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

KPCG_HUMAN
θ value	3.18553e-13 (rank : 444)	NC score	0.826103 (rank : 536)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1126	Shared Neighborhood Hits	817
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCI_HUMAN
θ value	3.18553e-13 (rank : 445)	NC score	0.855546 (rank : 484)
Query Neighborhood Hits	1275	Target Neighborhood Hits	885	Shared Neighborhood Hits	827
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

LIMK2_HUMAN
θ value	3.18553e-13 (rank : 446)	NC score	0.849129 (rank : 507)
Query Neighborhood Hits	1275	Target Neighborhood Hits	986	Shared Neighborhood Hits	809
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

SGK2_HUMAN
θ value	3.18553e-13 (rank : 447)	NC score	0.869039 (rank : 416)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	824
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ST17B_HUMAN
θ value	3.18553e-13 (rank : 448)	NC score	0.899493 (rank : 252)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	812
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

EPHA1_HUMAN
θ value	4.16044e-13 (rank : 449)	NC score	0.754229 (rank : 672)
Query Neighborhood Hits	1275	Target Neighborhood Hits	997	Shared Neighborhood Hits	796
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

KCC1B_MOUSE
θ value	4.16044e-13 (rank : 450)	NC score	0.893662 (rank : 295)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

ARBK2_HUMAN
θ value	5.43371e-13 (rank : 451)	NC score	0.854381 (rank : 490)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	810
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

EPHA5_MOUSE
θ value	5.43371e-13 (rank : 452)	NC score	0.774754 (rank : 623)
Query Neighborhood Hits	1275	Target Neighborhood Hits	950	Shared Neighborhood Hits	803
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA7_MOUSE
θ value	5.43371e-13 (rank : 453)	NC score	0.755971 (rank : 663)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1025	Shared Neighborhood Hits	808
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHB2_HUMAN
θ value	5.43371e-13 (rank : 454)	NC score	0.748830 (rank : 678)
Query Neighborhood Hits	1275	Target Neighborhood Hits	983	Shared Neighborhood Hits	801
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	5.43371e-13 (rank : 455)	NC score	0.748998 (rank : 677)
Query Neighborhood Hits	1275	Target Neighborhood Hits	982	Shared Neighborhood Hits	801
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

LYN_HUMAN
θ value	5.43371e-13 (rank : 456)	NC score	0.801563 (rank : 567)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1022	Shared Neighborhood Hits	832
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MELK_HUMAN
θ value	5.43371e-13 (rank : 457)	NC score	0.896760 (rank : 272)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	823
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

ROCK1_HUMAN
θ value	5.43371e-13 (rank : 458)	NC score	0.758057 (rank : 654)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2000	Shared Neighborhood Hits	888
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	5.43371e-13 (rank : 459)	NC score	0.742650 (rank : 693)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2126	Shared Neighborhood Hits	897
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

SBK1_HUMAN
θ value	5.43371e-13 (rank : 460)	NC score	0.897440 (rank : 264)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	808
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TESK1_MOUSE
θ value	5.43371e-13 (rank : 461)	NC score	0.880536 (rank : 358)
Query Neighborhood Hits	1275	Target Neighborhood Hits	862	Shared Neighborhood Hits	815
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TSSK6_MOUSE
θ value	5.43371e-13 (rank : 462)	NC score	0.907157 (rank : 192)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	813
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

DCAK2_HUMAN
θ value	7.09661e-13 (rank : 463)	NC score	0.882034 (rank : 351)
Query Neighborhood Hits	1275	Target Neighborhood Hits	862	Shared Neighborhood Hits	823
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
θ value	7.09661e-13 (rank : 464)	NC score	0.883437 (rank : 347)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	822
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

EPHA6_HUMAN
θ value	7.09661e-13 (rank : 465)	NC score	0.704977 (rank : 769)
Query Neighborhood Hits	1275	Target Neighborhood Hits	959	Shared Neighborhood Hits	787
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	7.09661e-13 (rank : 466)	NC score	0.754783 (rank : 668)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1053	Shared Neighborhood Hits	809
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

IKKB_HUMAN
θ value	7.09661e-13 (rank : 467)	NC score	0.914369 (rank : 158)
Query Neighborhood Hits	1275	Target Neighborhood Hits	980	Shared Neighborhood Hits	835
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

EPHA1_MOUSE
θ value	9.26847e-13 (rank : 468)	NC score	0.745594 (rank : 686)
Query Neighborhood Hits	1275	Target Neighborhood Hits	958	Shared Neighborhood Hits	784
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHB4_HUMAN
θ value	9.26847e-13 (rank : 469)	NC score	0.753299 (rank : 673)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1056	Shared Neighborhood Hits	803
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

KS6B2_MOUSE
θ value	9.26847e-13 (rank : 470)	NC score	0.873854 (rank : 384)
Query Neighborhood Hits	1275	Target Neighborhood Hits	871	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

LATS1_HUMAN
θ value	9.26847e-13 (rank : 471)	NC score	0.822187 (rank : 544)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1057	Shared Neighborhood Hits	879
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

MATK_HUMAN
θ value	9.26847e-13 (rank : 472)	NC score	0.797735 (rank : 581)
Query Neighborhood Hits	1275	Target Neighborhood Hits	954	Shared Neighborhood Hits	816
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MKNK2_MOUSE
θ value	9.26847e-13 (rank : 473)	NC score	0.868760 (rank : 419)
Query Neighborhood Hits	1275	Target Neighborhood Hits	819	Shared Neighborhood Hits	804
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

TSSK4_MOUSE
θ value	9.26847e-13 (rank : 474)	NC score	0.903172 (rank : 224)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	820
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

EPHB4_MOUSE
θ value	1.2105e-12 (rank : 475)	NC score	0.756163 (rank : 660)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1013	Shared Neighborhood Hits	801
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

FGFR1_HUMAN
θ value	1.2105e-12 (rank : 476)	NC score	0.765231 (rank : 639)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1069	Shared Neighborhood Hits	811
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	1.2105e-12 (rank : 477)	NC score	0.765268 (rank : 638)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1068	Shared Neighborhood Hits	811
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

KCC1B_HUMAN
θ value	1.2105e-12 (rank : 478)	NC score	0.892465 (rank : 306)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

LYN_MOUSE
θ value	1.2105e-12 (rank : 479)	NC score	0.802266 (rank : 564)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1023	Shared Neighborhood Hits	831
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FGFR2_HUMAN
θ value	1.58096e-12 (rank : 480)	NC score	0.770401 (rank : 629)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1062	Shared Neighborhood Hits	807
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	1.58096e-12 (rank : 481)	NC score	0.772678 (rank : 626)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1062	Shared Neighborhood Hits	808
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

PKN3_MOUSE
θ value	1.58096e-12 (rank : 482)	NC score	0.859563 (rank : 467)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	841
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

LATS1_MOUSE
θ value	2.0648e-12 (rank : 483)	NC score	0.821408 (rank : 547)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1027	Shared Neighborhood Hits	869
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

SRMS_MOUSE
θ value	2.0648e-12 (rank : 484)	NC score	0.801348 (rank : 571)
Query Neighborhood Hits	1275	Target Neighborhood Hits	964	Shared Neighborhood Hits	823
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TSSK6_HUMAN
θ value	2.0648e-12 (rank : 485)	NC score	0.906102 (rank : 198)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	814
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

MAPK2_HUMAN
θ value	2.69671e-12 (rank : 486)	NC score	0.874231 (rank : 380)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	809
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MKNK2_HUMAN
θ value	2.69671e-12 (rank : 487)	NC score	0.870323 (rank : 406)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	806
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MP2K1_HUMAN
θ value	2.69671e-12 (rank : 488)	NC score	0.911186 (rank : 168)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	814
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	2.69671e-12 (rank : 489)	NC score	0.910837 (rank : 169)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	814
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	2.69671e-12 (rank : 490)	NC score	0.911517 (rank : 166)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	815
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PASK_HUMAN
θ value	2.69671e-12 (rank : 491)	NC score	0.902152 (rank : 234)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	813
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PKN2_HUMAN
θ value	2.69671e-12 (rank : 492)	NC score	0.866417 (rank : 428)
Query Neighborhood Hits	1275	Target Neighborhood Hits	892	Shared Neighborhood Hits	824
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

SBK1_MOUSE
θ value	2.69671e-12 (rank : 493)	NC score	0.900295 (rank : 246)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	804
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

ST38L_MOUSE
θ value	2.69671e-12 (rank : 494)	NC score	0.822676 (rank : 543)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	784
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

AAK1_MOUSE
θ value	3.52202e-12 (rank : 495)	NC score	0.849487 (rank : 506)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1051	Shared Neighborhood Hits	855
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

KPCD_HUMAN
θ value	3.52202e-12 (rank : 496)	NC score	0.860502 (rank : 462)
Query Neighborhood Hits	1275	Target Neighborhood Hits	900	Shared Neighborhood Hits	820
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

M3K14_MOUSE
θ value	3.52202e-12 (rank : 497)	NC score	0.891452 (rank : 313)
Query Neighborhood Hits	1275	Target Neighborhood Hits	889	Shared Neighborhood Hits	816
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MAPK2_MOUSE
θ value	3.52202e-12 (rank : 498)	NC score	0.873508 (rank : 386)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	803
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

GRK7_HUMAN
θ value	4.59992e-12 (rank : 499)	NC score	0.871170 (rank : 399)
Query Neighborhood Hits	1275	Target Neighborhood Hits	820	Shared Neighborhood Hits	813
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

KPCZ_MOUSE
θ value	4.59992e-12 (rank : 500)	NC score	0.849051 (rank : 509)
Query Neighborhood Hits	1275	Target Neighborhood Hits	882	Shared Neighborhood Hits	824
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MAPK5_HUMAN
θ value	4.59992e-12 (rank : 501)	NC score	0.838083 (rank : 524)
Query Neighborhood Hits	1275	Target Neighborhood Hits	795	Shared Neighborhood Hits	776
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

PKN1_MOUSE
θ value	4.59992e-12 (rank : 502)	NC score	0.863587 (rank : 443)
Query Neighborhood Hits	1275	Target Neighborhood Hits	888	Shared Neighborhood Hits	821
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_MOUSE
θ value	4.59992e-12 (rank : 503)	NC score	0.866378 (rank : 429)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	821
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PRKX_MOUSE
θ value	4.59992e-12 (rank : 504)	NC score	0.875637 (rank : 371)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	832
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

RON_HUMAN
θ value	4.59992e-12 (rank : 505)	NC score	0.771069 (rank : 628)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	794
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

STK38_HUMAN
θ value	4.59992e-12 (rank : 506)	NC score	0.832913 (rank : 533)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	793
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	4.59992e-12 (rank : 507)	NC score	0.833409 (rank : 529)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	793
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

TNI3K_MOUSE
θ value	4.59992e-12 (rank : 508)	NC score	0.736155 (rank : 706)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1079	Shared Neighborhood Hits	790
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TXK_MOUSE
θ value	4.59992e-12 (rank : 509)	NC score	0.786199 (rank : 606)
Query Neighborhood Hits	1275	Target Neighborhood Hits	980	Shared Neighborhood Hits	804
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

GAK_MOUSE
θ value	6.00763e-12 (rank : 510)	NC score	0.860469 (rank : 463)
Query Neighborhood Hits	1275	Target Neighborhood Hits	964	Shared Neighborhood Hits	819
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KPCB_HUMAN
θ value	6.00763e-12 (rank : 511)	NC score	0.825576 (rank : 538)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1121	Shared Neighborhood Hits	821
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	6.00763e-12 (rank : 512)	NC score	0.826282 (rank : 535)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1117	Shared Neighborhood Hits	820
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

NTRK3_HUMAN
θ value	6.00763e-12 (rank : 513)	NC score	0.732953 (rank : 715)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1115	Shared Neighborhood Hits	788
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

HCK_HUMAN
θ value	7.84624e-12 (rank : 514)	NC score	0.786667 (rank : 605)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1035	Shared Neighborhood Hits	825
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

IKKE_MOUSE
θ value	7.84624e-12 (rank : 515)	NC score	0.903872 (rank : 221)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	803
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MAPK5_MOUSE
θ value	7.84624e-12 (rank : 516)	NC score	0.840160 (rank : 520)
Query Neighborhood Hits	1275	Target Neighborhood Hits	799	Shared Neighborhood Hits	781
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

PDK1L_MOUSE
θ value	7.84624e-12 (rank : 517)	NC score	0.915451 (rank : 150)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	809
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

RAF1_HUMAN
θ value	7.84624e-12 (rank : 518)	NC score	0.863814 (rank : 441)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	826
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RON_MOUSE
θ value	7.84624e-12 (rank : 519)	NC score	0.762538 (rank : 642)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	788
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

TESK1_HUMAN
θ value	7.84624e-12 (rank : 520)	NC score	0.880127 (rank : 361)
Query Neighborhood Hits	1275	Target Neighborhood Hits	864	Shared Neighborhood Hits	818
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

WNK1_HUMAN
θ value	7.84624e-12 (rank : 521)	NC score	0.856136 (rank : 480)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1158	Shared Neighborhood Hits	849
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	7.84624e-12 (rank : 522)	NC score	0.854338 (rank : 491)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1179	Shared Neighborhood Hits	851
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

GAK_HUMAN
θ value	1.02475e-11 (rank : 523)	NC score	0.863900 (rank : 440)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1028	Shared Neighborhood Hits	830
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

IKKE_HUMAN
θ value	1.02475e-11 (rank : 524)	NC score	0.902380 (rank : 231)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	805
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

NIM1_MOUSE
θ value	1.02475e-11 (rank : 525)	NC score	0.895461 (rank : 280)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

TNI3K_HUMAN
θ value	1.02475e-11 (rank : 526)	NC score	0.731092 (rank : 719)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1084	Shared Neighborhood Hits	795
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

F5006_MOUSE
θ value	1.33837e-11 (rank : 527)	NC score	0.871536 (rank : 398)
Query Neighborhood Hits	1275	Target Neighborhood Hits	793	Shared Neighborhood Hits	789
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

IKKB_MOUSE
θ value	1.33837e-11 (rank : 528)	NC score	0.912551 (rank : 164)
Query Neighborhood Hits	1275	Target Neighborhood Hits	984	Shared Neighborhood Hits	830
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MKNK1_MOUSE
θ value	1.33837e-11 (rank : 529)	NC score	0.862710 (rank : 451)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	794
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MP2K5_MOUSE
θ value	1.33837e-11 (rank : 530)	NC score	0.905759 (rank : 202)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	822
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K7_HUMAN
θ value	1.33837e-11 (rank : 531)	NC score	0.899257 (rank : 255)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

PIM1_MOUSE
θ value	1.33837e-11 (rank : 532)	NC score	0.870552 (rank : 404)
Query Neighborhood Hits	1275	Target Neighborhood Hits	787	Shared Neighborhood Hits	773
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

TIE2_HUMAN
θ value	1.33837e-11 (rank : 533)	NC score	0.756582 (rank : 658)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1192	Shared Neighborhood Hits	811
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

KPCZ_HUMAN
θ value	1.74796e-11 (rank : 534)	NC score	0.849053 (rank : 508)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	823
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

M3K14_HUMAN
θ value	1.74796e-11 (rank : 535)	NC score	0.896271 (rank : 274)
Query Neighborhood Hits	1275	Target Neighborhood Hits	887	Shared Neighborhood Hits	834
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

NIM1_HUMAN
θ value	1.74796e-11 (rank : 536)	NC score	0.894353 (rank : 287)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	825
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PIM1_HUMAN
θ value	1.74796e-11 (rank : 537)	NC score	0.874152 (rank : 381)
Query Neighborhood Hits	1275	Target Neighborhood Hits	797	Shared Neighborhood Hits	783
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

TIE2_MOUSE
θ value	1.74796e-11 (rank : 538)	NC score	0.755353 (rank : 667)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1204	Shared Neighborhood Hits	812
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

FGFR3_HUMAN
θ value	2.28291e-11 (rank : 539)	NC score	0.759605 (rank : 649)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1042	Shared Neighborhood Hits	806
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

KSYK_MOUSE
θ value	2.28291e-11 (rank : 540)	NC score	0.801401 (rank : 570)
Query Neighborhood Hits	1275	Target Neighborhood Hits	944	Shared Neighborhood Hits	810
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MERTK_HUMAN
θ value	2.28291e-11 (rank : 541)	NC score	0.720731 (rank : 742)
Query Neighborhood Hits	1275	Target Neighborhood Hits	988	Shared Neighborhood Hits	772
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

PDK1L_HUMAN
θ value	2.28291e-11 (rank : 542)	NC score	0.915191 (rank : 154)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	809
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PKN1_HUMAN
θ value	2.28291e-11 (rank : 543)	NC score	0.863102 (rank : 448)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	829
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

SRMS_HUMAN
θ value	2.28291e-11 (rank : 544)	NC score	0.793893 (rank : 591)
Query Neighborhood Hits	1275	Target Neighborhood Hits	946	Shared Neighborhood Hits	822
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

TITIN_HUMAN
θ value	2.28291e-11 (rank : 545)	NC score	0.694286 (rank : 779)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2923	Shared Neighborhood Hits	989
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

FGFR3_MOUSE
θ value	2.98157e-11 (rank : 546)	NC score	0.756109 (rank : 662)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1059	Shared Neighborhood Hits	806
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

ITK_HUMAN
θ value	2.98157e-11 (rank : 547)	NC score	0.796508 (rank : 583)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1016	Shared Neighborhood Hits	819
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

KSYK_HUMAN
θ value	2.98157e-11 (rank : 548)	NC score	0.801552 (rank : 568)
Query Neighborhood Hits	1275	Target Neighborhood Hits	901	Shared Neighborhood Hits	803
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

WNK4_MOUSE
θ value	2.98157e-11 (rank : 549)	NC score	0.852907 (rank : 494)
Query Neighborhood Hits	1275	Target Neighborhood Hits	961	Shared Neighborhood Hits	816
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

FRK_HUMAN
θ value	3.89403e-11 (rank : 550)	NC score	0.799191 (rank : 580)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1058	Shared Neighborhood Hits	826
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ITK_MOUSE
θ value	3.89403e-11 (rank : 551)	NC score	0.796913 (rank : 582)
Query Neighborhood Hits	1275	Target Neighborhood Hits	985	Shared Neighborhood Hits	817
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LATS2_HUMAN
θ value	3.89403e-11 (rank : 552)	NC score	0.817250 (rank : 549)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

M3K12_HUMAN
θ value	3.89403e-11 (rank : 553)	NC score	0.872913 (rank : 389)
Query Neighborhood Hits	1275	Target Neighborhood Hits	940	Shared Neighborhood Hits	840
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	3.89403e-11 (rank : 554)	NC score	0.872756 (rank : 390)
Query Neighborhood Hits	1275	Target Neighborhood Hits	957	Shared Neighborhood Hits	837
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

PKN3_HUMAN
θ value	3.89403e-11 (rank : 555)	NC score	0.860582 (rank : 460)
Query Neighborhood Hits	1275	Target Neighborhood Hits	893	Shared Neighborhood Hits	828
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PRKX_HUMAN
θ value	3.89403e-11 (rank : 556)	NC score	0.875221 (rank : 374)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	831
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

RAF1_MOUSE
θ value	3.89403e-11 (rank : 557)	NC score	0.863358 (rank : 446)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	830
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

WNK4_HUMAN
θ value	3.89403e-11 (rank : 558)	NC score	0.850410 (rank : 504)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1043	Shared Neighborhood Hits	833
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

BMP2K_HUMAN
θ value	5.08577e-11 (rank : 559)	NC score	0.859538 (rank : 468)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	786
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

MUSK_HUMAN
θ value	5.08577e-11 (rank : 560)	NC score	0.702296 (rank : 772)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1074	Shared Neighborhood Hits	781
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

PIM2_MOUSE
θ value	5.08577e-11 (rank : 561)	NC score	0.873700 (rank : 385)
Query Neighborhood Hits	1275	Target Neighborhood Hits	809	Shared Neighborhood Hits	793
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

HCK_MOUSE
θ value	6.64225e-11 (rank : 562)	NC score	0.782972 (rank : 615)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1029	Shared Neighborhood Hits	822
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

MERTK_MOUSE
θ value	6.64225e-11 (rank : 563)	NC score	0.727750 (rank : 728)
Query Neighborhood Hits	1275	Target Neighborhood Hits	974	Shared Neighborhood Hits	761
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

SGK1_HUMAN
θ value	6.64225e-11 (rank : 564)	NC score	0.870372 (rank : 405)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	827
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

TIE1_HUMAN
θ value	6.64225e-11 (rank : 565)	NC score	0.733085 (rank : 714)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1241	Shared Neighborhood Hits	814
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

WNK3_HUMAN
θ value	6.64225e-11 (rank : 566)	NC score	0.857301 (rank : 472)
Query Neighborhood Hits	1275	Target Neighborhood Hits	948	Shared Neighborhood Hits	784
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

DCAK1_HUMAN
θ value	8.67504e-11 (rank : 567)	NC score	0.888563 (rank : 321)
Query Neighborhood Hits	1275	Target Neighborhood Hits	877	Shared Neighborhood Hits	831
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

LATS2_MOUSE
θ value	8.67504e-11 (rank : 568)	NC score	0.815548 (rank : 551)
Query Neighborhood Hits	1275	Target Neighborhood Hits	879	Shared Neighborhood Hits	816
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

MLTK_HUMAN
θ value	8.67504e-11 (rank : 569)	NC score	0.860699 (rank : 459)
Query Neighborhood Hits	1275	Target Neighborhood Hits	911	Shared Neighborhood Hits	816
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MUSK_MOUSE
θ value	8.67504e-11 (rank : 570)	NC score	0.697680 (rank : 777)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1057	Shared Neighborhood Hits	777
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

SGK1_MOUSE
θ value	8.67504e-11 (rank : 571)	NC score	0.869733 (rank : 410)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	827
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

DCAK1_MOUSE
θ value	1.133e-10 (rank : 572)	NC score	0.887908 (rank : 326)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	824
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

MET_HUMAN
θ value	1.133e-10 (rank : 573)	NC score	0.760230 (rank : 647)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	792
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	1.133e-10 (rank : 574)	NC score	0.761399 (rank : 645)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	795
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MP2K5_HUMAN
θ value	1.133e-10 (rank : 575)	NC score	0.902643 (rank : 230)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PMYT1_MOUSE
θ value	1.133e-10 (rank : 576)	NC score	0.891531 (rank : 312)
Query Neighborhood Hits	1275	Target Neighborhood Hits	910	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

TESK2_HUMAN
θ value	1.133e-10 (rank : 577)	NC score	0.875562 (rank : 373)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	806
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

AAK1_HUMAN
θ value	1.47974e-10 (rank : 578)	NC score	0.851196 (rank : 502)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1077	Shared Neighborhood Hits	868
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

EPHA8_HUMAN
θ value	1.47974e-10 (rank : 579)	NC score	0.742024 (rank : 694)
Query Neighborhood Hits	1275	Target Neighborhood Hits	956	Shared Neighborhood Hits	797
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

ROCK2_MOUSE
θ value	1.47974e-10 (rank : 580)	NC score	0.754474 (rank : 670)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2072	Shared Neighborhood Hits	896
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

SGK3_MOUSE
θ value	1.47974e-10 (rank : 581)	NC score	0.865042 (rank : 435)
Query Neighborhood Hits	1275	Target Neighborhood Hits	882	Shared Neighborhood Hits	819
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

TSSK4_HUMAN
θ value	1.47974e-10 (rank : 582)	NC score	0.895274 (rank : 281)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	819
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

WNK2_HUMAN
θ value	1.47974e-10 (rank : 583)	NC score	0.848278 (rank : 511)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1407	Shared Neighborhood Hits	912
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

FGFR4_HUMAN
θ value	1.9326e-10 (rank : 584)	NC score	0.749406 (rank : 676)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1037	Shared Neighborhood Hits	795
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

INSR_HUMAN
θ value	1.9326e-10 (rank : 585)	NC score	0.742877 (rank : 692)
Query Neighborhood Hits	1275	Target Neighborhood Hits	963	Shared Neighborhood Hits	802
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

KGP2_HUMAN
θ value	1.9326e-10 (rank : 586)	NC score	0.861422 (rank : 457)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1023	Shared Neighborhood Hits	840
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PIM3_HUMAN
θ value	1.9326e-10 (rank : 587)	NC score	0.866081 (rank : 431)
Query Neighborhood Hits	1275	Target Neighborhood Hits	789	Shared Neighborhood Hits	777
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

RIPK1_MOUSE
θ value	1.9326e-10 (rank : 588)	NC score	0.866535 (rank : 425)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	830
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

ROCK2_HUMAN
θ value	1.9326e-10 (rank : 589)	NC score	0.760831 (rank : 646)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2073	Shared Neighborhood Hits	900
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SGK3_HUMAN
θ value	1.9326e-10 (rank : 590)	NC score	0.864692 (rank : 439)
Query Neighborhood Hits	1275	Target Neighborhood Hits	877	Shared Neighborhood Hits	819
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

TIE1_MOUSE
θ value	1.9326e-10 (rank : 591)	NC score	0.733658 (rank : 713)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1266	Shared Neighborhood Hits	813
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHA8_MOUSE
θ value	2.52405e-10 (rank : 592)	NC score	0.736679 (rank : 704)
Query Neighborhood Hits	1275	Target Neighborhood Hits	969	Shared Neighborhood Hits	795
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

KC1AL_HUMAN
θ value	2.52405e-10 (rank : 593)	NC score	0.748308 (rank : 680)
Query Neighborhood Hits	1275	Target Neighborhood Hits	734	Shared Neighborhood Hits	728
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KC1A_HUMAN
θ value	2.52405e-10 (rank : 594)	NC score	0.746822 (rank : 683)
Query Neighborhood Hits	1275	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	2.52405e-10 (rank : 595)	NC score	0.746822 (rank : 684)
Query Neighborhood Hits	1275	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

MP2K6_MOUSE
θ value	2.52405e-10 (rank : 596)	NC score	0.894363 (rank : 286)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	815
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

PIM2_HUMAN
θ value	2.52405e-10 (rank : 597)	NC score	0.872128 (rank : 393)
Query Neighborhood Hits	1275	Target Neighborhood Hits	808	Shared Neighborhood Hits	799
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PRKY_HUMAN
θ value	2.52405e-10 (rank : 598)	NC score	0.885430 (rank : 337)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	831
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

ZAP70_HUMAN
θ value	2.52405e-10 (rank : 599)	NC score	0.800757 (rank : 576)
Query Neighborhood Hits	1275	Target Neighborhood Hits	893	Shared Neighborhood Hits	810
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ERBB4_HUMAN
θ value	3.29651e-10 (rank : 600)	NC score	0.764973 (rank : 640)
Query Neighborhood Hits	1275	Target Neighborhood Hits	910	Shared Neighborhood Hits	798
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

MP2K6_HUMAN
θ value	3.29651e-10 (rank : 601)	NC score	0.894007 (rank : 290)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	814
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

F5006_HUMAN
θ value	4.30538e-10 (rank : 602)	NC score	0.861612 (rank : 456)
Query Neighborhood Hits	1275	Target Neighborhood Hits	794	Shared Neighborhood Hits	784
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

INSR_MOUSE
θ value	4.30538e-10 (rank : 603)	NC score	0.739074 (rank : 699)
Query Neighborhood Hits	1275	Target Neighborhood Hits	968	Shared Neighborhood Hits	800
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

M3K7_HUMAN
θ value	4.30538e-10 (rank : 604)	NC score	0.874823 (rank : 377)
Query Neighborhood Hits	1275	Target Neighborhood Hits	892	Shared Neighborhood Hits	820
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	4.30538e-10 (rank : 605)	NC score	0.874931 (rank : 375)
Query Neighborhood Hits	1275	Target Neighborhood Hits	892	Shared Neighborhood Hits	821
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MP2K3_HUMAN
θ value	4.30538e-10 (rank : 606)	NC score	0.897152 (rank : 267)
Query Neighborhood Hits	1275	Target Neighborhood Hits	825	Shared Neighborhood Hits	810
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K3_MOUSE
θ value	4.30538e-10 (rank : 607)	NC score	0.896885 (rank : 270)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	811
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

TESK2_MOUSE
θ value	4.30538e-10 (rank : 608)	NC score	0.874409 (rank : 379)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	805
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

IKKA_MOUSE
θ value	5.62301e-10 (rank : 609)	NC score	0.908653 (rank : 182)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	826
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KGP2_MOUSE
θ value	5.62301e-10 (rank : 610)	NC score	0.859612 (rank : 466)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1029	Shared Neighborhood Hits	840
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

M3KL4_HUMAN
θ value	5.62301e-10 (rank : 611)	NC score	0.843465 (rank : 517)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1087	Shared Neighborhood Hits	837
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MLTK_MOUSE
θ value	5.62301e-10 (rank : 612)	NC score	0.860946 (rank : 458)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	812
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

NRK_MOUSE
θ value	5.62301e-10 (rank : 613)	NC score	0.878945 (rank : 364)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	840
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

PTK7_HUMAN
θ value	5.62301e-10 (rank : 614)	NC score	0.696413 (rank : 778)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1103	Shared Neighborhood Hits	773
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PIM3_MOUSE
θ value	7.34386e-10 (rank : 615)	NC score	0.862227 (rank : 455)
Query Neighborhood Hits	1275	Target Neighborhood Hits	783	Shared Neighborhood Hits	771
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

ZAP70_MOUSE
θ value	7.34386e-10 (rank : 616)	NC score	0.799512 (rank : 578)
Query Neighborhood Hits	1275	Target Neighborhood Hits	905	Shared Neighborhood Hits	813
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

FAK1_HUMAN
θ value	9.59137e-10 (rank : 617)	NC score	0.802031 (rank : 565)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	814
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	9.59137e-10 (rank : 618)	NC score	0.802512 (rank : 563)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	810
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_MOUSE
θ value	9.59137e-10 (rank : 619)	NC score	0.789166 (rank : 598)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	795
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

INSRR_MOUSE
θ value	9.59137e-10 (rank : 620)	NC score	0.724693 (rank : 736)
Query Neighborhood Hits	1275	Target Neighborhood Hits	961	Shared Neighborhood Hits	776
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KPCD_MOUSE
θ value	9.59137e-10 (rank : 621)	NC score	0.854531 (rank : 489)
Query Neighborhood Hits	1275	Target Neighborhood Hits	888	Shared Neighborhood Hits	818
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MAPK3_HUMAN
θ value	9.59137e-10 (rank : 622)	NC score	0.866824 (rank : 424)
Query Neighborhood Hits	1275	Target Neighborhood Hits	807	Shared Neighborhood Hits	785
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

UFO_HUMAN
θ value	9.59137e-10 (rank : 623)	NC score	0.729496 (rank : 724)
Query Neighborhood Hits	1275	Target Neighborhood Hits	981	Shared Neighborhood Hits	763
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	9.59137e-10 (rank : 624)	NC score	0.732914 (rank : 716)
Query Neighborhood Hits	1275	Target Neighborhood Hits	988	Shared Neighborhood Hits	761
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ACK1_MOUSE
θ value	1.25267e-09 (rank : 625)	NC score	0.775476 (rank : 622)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1080	Shared Neighborhood Hits	882
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

MAPK3_MOUSE
θ value	1.25267e-09 (rank : 626)	NC score	0.869687 (rank : 412)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	794
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

RIPK3_HUMAN
θ value	1.25267e-09 (rank : 627)	NC score	0.848983 (rank : 510)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	800
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

ACK1_HUMAN
θ value	1.63604e-09 (rank : 628)	NC score	0.776186 (rank : 620)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1140	Shared Neighborhood Hits	895
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

MASTL_HUMAN
θ value	1.63604e-09 (rank : 629)	NC score	0.864878 (rank : 437)
Query Neighborhood Hits	1275	Target Neighborhood Hits	894	Shared Neighborhood Hits	827
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

NRK_HUMAN
θ value	1.63604e-09 (rank : 630)	NC score	0.878587 (rank : 365)
Query Neighborhood Hits	1275	Target Neighborhood Hits	931	Shared Neighborhood Hits	837
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

PMYT1_HUMAN
θ value	1.63604e-09 (rank : 631)	NC score	0.884713 (rank : 340)
Query Neighborhood Hits	1275	Target Neighborhood Hits	814	Shared Neighborhood Hits	796
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

IKKA_HUMAN
θ value	2.13673e-09 (rank : 632)	NC score	0.908320 (rank : 184)
Query Neighborhood Hits	1275	Target Neighborhood Hits	863	Shared Neighborhood Hits	827
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

INSRR_HUMAN
θ value	2.13673e-09 (rank : 633)	NC score	0.724539 (rank : 737)
Query Neighborhood Hits	1275	Target Neighborhood Hits	950	Shared Neighborhood Hits	775
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KIT_HUMAN
θ value	2.13673e-09 (rank : 634)	NC score	0.716113 (rank : 747)
Query Neighborhood Hits	1275	Target Neighborhood Hits	953	Shared Neighborhood Hits	787
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

FAK2_HUMAN
θ value	2.79066e-09 (rank : 635)	NC score	0.783380 (rank : 614)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	791
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FGFR4_MOUSE
θ value	2.79066e-09 (rank : 636)	NC score	0.729520 (rank : 722)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1026	Shared Neighborhood Hits	785
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

MASTL_MOUSE
θ value	3.64472e-09 (rank : 637)	NC score	0.863424 (rank : 445)
Query Neighborhood Hits	1275	Target Neighborhood Hits	862	Shared Neighborhood Hits	823
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

PGFRA_HUMAN
θ value	3.64472e-09 (rank : 638)	NC score	0.723042 (rank : 738)
Query Neighborhood Hits	1275	Target Neighborhood Hits	980	Shared Neighborhood Hits	786
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	3.64472e-09 (rank : 639)	NC score	0.721607 (rank : 740)
Query Neighborhood Hits	1275	Target Neighborhood Hits	975	Shared Neighborhood Hits	783
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

ARAF_HUMAN
θ value	4.76016e-09 (rank : 640)	NC score	0.855578 (rank : 483)
Query Neighborhood Hits	1275	Target Neighborhood Hits	924	Shared Neighborhood Hits	831
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

BRAF1_HUMAN
θ value	4.76016e-09 (rank : 641)	NC score	0.860576 (rank : 461)
Query Neighborhood Hits	1275	Target Neighborhood Hits	883	Shared Neighborhood Hits	821
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

EGFR_MOUSE
θ value	4.76016e-09 (rank : 642)	NC score	0.769367 (rank : 633)
Query Neighborhood Hits	1275	Target Neighborhood Hits	927	Shared Neighborhood Hits	803
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

KGP1A_HUMAN
θ value	4.76016e-09 (rank : 643)	NC score	0.857267 (rank : 473)
Query Neighborhood Hits	1275	Target Neighborhood Hits	901	Shared Neighborhood Hits	822
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	4.76016e-09 (rank : 644)	NC score	0.856775 (rank : 477)
Query Neighborhood Hits	1275	Target Neighborhood Hits	921	Shared Neighborhood Hits	826
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	4.76016e-09 (rank : 645)	NC score	0.856821 (rank : 476)
Query Neighborhood Hits	1275	Target Neighborhood Hits	922	Shared Neighborhood Hits	826
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KIT_MOUSE
θ value	4.76016e-09 (rank : 646)	NC score	0.708933 (rank : 764)
Query Neighborhood Hits	1275	Target Neighborhood Hits	949	Shared Neighborhood Hits	784
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

MP2K4_HUMAN
θ value	4.76016e-09 (rank : 647)	NC score	0.891933 (rank : 309)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	817
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	4.76016e-09 (rank : 648)	NC score	0.892141 (rank : 308)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

OBSCN_HUMAN
θ value	4.76016e-09 (rank : 649)	NC score	0.786873 (rank : 604)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1931	Shared Neighborhood Hits	925
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

RET_MOUSE
θ value	4.76016e-09 (rank : 650)	NC score	0.773458 (rank : 625)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	797
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIPK1_HUMAN
θ value	4.76016e-09 (rank : 651)	NC score	0.868788 (rank : 417)
Query Neighborhood Hits	1275	Target Neighborhood Hits	891	Shared Neighborhood Hits	833
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

STK35_HUMAN
θ value	4.76016e-09 (rank : 652)	NC score	0.909939 (rank : 175)
Query Neighborhood Hits	1275	Target Neighborhood Hits	825	Shared Neighborhood Hits	810
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

TBK1_HUMAN
θ value	4.76016e-09 (rank : 653)	NC score	0.889116 (rank : 316)
Query Neighborhood Hits	1275	Target Neighborhood Hits	861	Shared Neighborhood Hits	799
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TTK_HUMAN
θ value	4.76016e-09 (rank : 654)	NC score	0.887897 (rank : 327)
Query Neighborhood Hits	1275	Target Neighborhood Hits	816	Shared Neighborhood Hits	773
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

M3K11_HUMAN
θ value	6.21693e-09 (rank : 655)	NC score	0.852265 (rank : 498)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1136	Shared Neighborhood Hits	868
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

RET_HUMAN
θ value	6.21693e-09 (rank : 656)	NC score	0.771673 (rank : 627)
Query Neighborhood Hits	1275	Target Neighborhood Hits	873	Shared Neighborhood Hits	799
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

TBK1_MOUSE
θ value	6.21693e-09 (rank : 657)	NC score	0.887820 (rank : 328)
Query Neighborhood Hits	1275	Target Neighborhood Hits	893	Shared Neighborhood Hits	801
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

VGFR2_HUMAN
θ value	8.11959e-09 (rank : 658)	NC score	0.701470 (rank : 773)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1103	Shared Neighborhood Hits	792
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	8.11959e-09 (rank : 659)	NC score	0.704994 (rank : 768)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1089	Shared Neighborhood Hits	790
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

EGFR_HUMAN
θ value	1.06045e-08 (rank : 660)	NC score	0.768392 (rank : 635)
Query Neighborhood Hits	1275	Target Neighborhood Hits	939	Shared Neighborhood Hits	800
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

ERBB2_MOUSE
θ value	1.38499e-08 (rank : 661)	NC score	0.756912 (rank : 657)
Query Neighborhood Hits	1275	Target Neighborhood Hits	918	Shared Neighborhood Hits	816
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

M3K9_HUMAN
θ value	1.38499e-08 (rank : 662)	NC score	0.852220 (rank : 500)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1123	Shared Neighborhood Hits	848
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

STK16_MOUSE
θ value	1.38499e-08 (rank : 663)	NC score	0.896801 (rank : 271)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	811
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

TYRO3_MOUSE
θ value	1.38499e-08 (rank : 664)	NC score	0.719703 (rank : 746)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1007	Shared Neighborhood Hits	774
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

VGFR1_HUMAN
θ value	1.38499e-08 (rank : 665)	NC score	0.702674 (rank : 771)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1109	Shared Neighborhood Hits	798
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR3_HUMAN
θ value	1.38499e-08 (rank : 666)	NC score	0.714952 (rank : 752)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1037	Shared Neighborhood Hits	786
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

E2AK1_MOUSE
θ value	1.80886e-08 (rank : 667)	NC score	0.888902 (rank : 318)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	805
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

LTK_MOUSE
θ value	1.80886e-08 (rank : 668)	NC score	0.698919 (rank : 776)
Query Neighborhood Hits	1275	Target Neighborhood Hits	770	Shared Neighborhood Hits	743
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

TYRO3_HUMAN
θ value	1.80886e-08 (rank : 669)	NC score	0.720425 (rank : 744)
Query Neighborhood Hits	1275	Target Neighborhood Hits	995	Shared Neighborhood Hits	774
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

VGFR1_MOUSE
θ value	1.80886e-08 (rank : 670)	NC score	0.710426 (rank : 761)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1118	Shared Neighborhood Hits	801
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR3_MOUSE
θ value	1.80886e-08 (rank : 671)	NC score	0.715493 (rank : 749)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1056	Shared Neighborhood Hits	784
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

CSF1R_HUMAN
θ value	2.36244e-08 (rank : 672)	NC score	0.683478 (rank : 786)
Query Neighborhood Hits	1275	Target Neighborhood Hits	943	Shared Neighborhood Hits	781
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ERBB2_HUMAN
θ value	2.36244e-08 (rank : 673)	NC score	0.752816 (rank : 674)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1073	Shared Neighborhood Hits	823
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ANKK1_HUMAN
θ value	3.08544e-08 (rank : 674)	NC score	0.645978 (rank : 806)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1075	Shared Neighborhood Hits	789
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

DDR1_HUMAN
θ value	3.08544e-08 (rank : 675)	NC score	0.729571 (rank : 721)
Query Neighborhood Hits	1275	Target Neighborhood Hits	819	Shared Neighborhood Hits	767
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

E2AK1_HUMAN
θ value	3.08544e-08 (rank : 676)	NC score	0.885946 (rank : 334)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	810
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK4_MOUSE
θ value	3.08544e-08 (rank : 677)	NC score	0.865711 (rank : 433)
Query Neighborhood Hits	1275	Target Neighborhood Hits	984	Shared Neighborhood Hits	839
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

M3K10_HUMAN
θ value	3.08544e-08 (rank : 678)	NC score	0.848099 (rank : 512)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1071	Shared Neighborhood Hits	835
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

PGFRB_HUMAN
θ value	3.08544e-08 (rank : 679)	NC score	0.715734 (rank : 748)
Query Neighborhood Hits	1275	Target Neighborhood Hits	962	Shared Neighborhood Hits	781
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

CSF1R_MOUSE
θ value	4.0297e-08 (rank : 680)	NC score	0.676106 (rank : 789)
Query Neighborhood Hits	1275	Target Neighborhood Hits	983	Shared Neighborhood Hits	779
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

E2AK3_HUMAN
θ value	5.26297e-08 (rank : 681)	NC score	0.887810 (rank : 329)
Query Neighborhood Hits	1275	Target Neighborhood Hits	859	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

E2AK3_MOUSE
θ value	5.26297e-08 (rank : 682)	NC score	0.885804 (rank : 335)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	822
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

E2AK4_HUMAN
θ value	5.26297e-08 (rank : 683)	NC score	0.870824 (rank : 402)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1012	Shared Neighborhood Hits	845
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

FLT3_MOUSE
θ value	5.26297e-08 (rank : 684)	NC score	0.709416 (rank : 762)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	778
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

ROR2_HUMAN
θ value	5.26297e-08 (rank : 685)	NC score	0.735377 (rank : 712)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1014	Shared Neighborhood Hits	787
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ARAF_MOUSE
θ value	6.87365e-08 (rank : 686)	NC score	0.855431 (rank : 486)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	826
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

DDR1_MOUSE
θ value	8.97725e-08 (rank : 687)	NC score	0.729978 (rank : 720)
Query Neighborhood Hits	1275	Target Neighborhood Hits	818	Shared Neighborhood Hits	766
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

FLT3_HUMAN
θ value	8.97725e-08 (rank : 688)	NC score	0.712285 (rank : 759)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	779
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

IGF1R_MOUSE
θ value	8.97725e-08 (rank : 689)	NC score	0.725868 (rank : 732)
Query Neighborhood Hits	1275	Target Neighborhood Hits	973	Shared Neighborhood Hits	787
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

PGFRB_MOUSE
θ value	8.97725e-08 (rank : 690)	NC score	0.715439 (rank : 750)
Query Neighborhood Hits	1275	Target Neighborhood Hits	960	Shared Neighborhood Hits	786
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

RIPK2_MOUSE
θ value	8.97725e-08 (rank : 691)	NC score	0.801163 (rank : 573)
Query Neighborhood Hits	1275	Target Neighborhood Hits	776	Shared Neighborhood Hits	748
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

ANKK1_MOUSE
θ value	1.17247e-07 (rank : 692)	NC score	0.660341 (rank : 796)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1072	Shared Neighborhood Hits	793
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

BMR1A_HUMAN
θ value	1.17247e-07 (rank : 693)	NC score	0.737229 (rank : 702)
Query Neighborhood Hits	1275	Target Neighborhood Hits	759	Shared Neighborhood Hits	742
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	1.17247e-07 (rank : 694)	NC score	0.735920 (rank : 708)
Query Neighborhood Hits	1275	Target Neighborhood Hits	758	Shared Neighborhood Hits	742
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

RIPK5_HUMAN
θ value	1.17247e-07 (rank : 695)	NC score	0.872377 (rank : 392)
Query Neighborhood Hits	1275	Target Neighborhood Hits	864	Shared Neighborhood Hits	827
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	1.17247e-07 (rank : 696)	NC score	0.871599 (rank : 397)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	828
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

STK16_HUMAN
θ value	1.17247e-07 (rank : 697)	NC score	0.898906 (rank : 258)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	812
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

ALK_HUMAN
θ value	1.53129e-07 (rank : 698)	NC score	0.693783 (rank : 780)
Query Neighborhood Hits	1275	Target Neighborhood Hits	795	Shared Neighborhood Hits	738
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

BMPR2_HUMAN
θ value	1.53129e-07 (rank : 699)	NC score	0.722438 (rank : 739)
Query Neighborhood Hits	1275	Target Neighborhood Hits	736	Shared Neighborhood Hits	701
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

IGF1R_HUMAN
θ value	1.53129e-07 (rank : 700)	NC score	0.725002 (rank : 735)
Query Neighborhood Hits	1275	Target Neighborhood Hits	977	Shared Neighborhood Hits	787
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LTK_HUMAN
θ value	1.53129e-07 (rank : 701)	NC score	0.693237 (rank : 781)
Query Neighborhood Hits	1275	Target Neighborhood Hits	774	Shared Neighborhood Hits	746
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

TTBK1_HUMAN
θ value	1.53129e-07 (rank : 702)	NC score	0.768848 (rank : 634)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1058	Shared Neighborhood Hits	773
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

VRK1_HUMAN
θ value	1.53129e-07 (rank : 703)	NC score	0.533110 (rank : 827)
Query Neighborhood Hits	1275	Target Neighborhood Hits	584	Shared Neighborhood Hits	575
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

CI096_HUMAN
θ value	1.99992e-07 (rank : 704)	NC score	0.910655 (rank : 171)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	799
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

KSR2_HUMAN
θ value	1.99992e-07 (rank : 705)	NC score	0.833209 (rank : 530)
Query Neighborhood Hits	1275	Target Neighborhood Hits	920	Shared Neighborhood Hits	844
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

TRIO_HUMAN
θ value	1.99992e-07 (rank : 706)	NC score	0.795946 (rank : 584)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1580	Shared Neighborhood Hits	871
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

BMPR2_MOUSE
θ value	2.61198e-07 (rank : 707)	NC score	0.721455 (rank : 741)
Query Neighborhood Hits	1275	Target Neighborhood Hits	738	Shared Neighborhood Hits	702
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1B_MOUSE
θ value	2.61198e-07 (rank : 708)	NC score	0.728556 (rank : 726)
Query Neighborhood Hits	1275	Target Neighborhood Hits	758	Shared Neighborhood Hits	741
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

ROR2_MOUSE
θ value	2.61198e-07 (rank : 709)	NC score	0.712806 (rank : 757)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1000	Shared Neighborhood Hits	765
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	2.61198e-07 (rank : 710)	NC score	0.735878 (rank : 709)
Query Neighborhood Hits	1275	Target Neighborhood Hits	907	Shared Neighborhood Hits	764
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

ALK_MOUSE
θ value	3.41135e-07 (rank : 711)	NC score	0.691159 (rank : 783)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	749
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

BMR1B_HUMAN
θ value	3.41135e-07 (rank : 712)	NC score	0.727088 (rank : 730)
Query Neighborhood Hits	1275	Target Neighborhood Hits	760	Shared Neighborhood Hits	740
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

ERBB3_MOUSE
θ value	3.41135e-07 (rank : 713)	NC score	0.727807 (rank : 727)
Query Neighborhood Hits	1275	Target Neighborhood Hits	898	Shared Neighborhood Hits	774
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

LRRK2_HUMAN
θ value	3.41135e-07 (rank : 714)	NC score	0.758196 (rank : 653)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1382	Shared Neighborhood Hits	817
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

STYK1_HUMAN
θ value	3.41135e-07 (rank : 715)	NC score	0.748578 (rank : 679)
Query Neighborhood Hits	1275	Target Neighborhood Hits	786	Shared Neighborhood Hits	763
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

TTK_MOUSE
θ value	3.41135e-07 (rank : 716)	NC score	0.883666 (rank : 344)
Query Neighborhood Hits	1275	Target Neighborhood Hits	803	Shared Neighborhood Hits	764
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

KC1D_HUMAN
θ value	4.45536e-07 (rank : 717)	NC score	0.735476 (rank : 710)
Query Neighborhood Hits	1275	Target Neighborhood Hits	737	Shared Neighborhood Hits	726
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	4.45536e-07 (rank : 718)	NC score	0.735474 (rank : 711)
Query Neighborhood Hits	1275	Target Neighborhood Hits	737	Shared Neighborhood Hits	726
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

LRRK2_MOUSE
θ value	4.45536e-07 (rank : 719)	NC score	0.743883 (rank : 690)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1359	Shared Neighborhood Hits	811
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

ACVR1_MOUSE
θ value	7.59969e-07 (rank : 720)	NC score	0.741934 (rank : 695)
Query Neighborhood Hits	1275	Target Neighborhood Hits	768	Shared Neighborhood Hits	753
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ERN1_HUMAN
θ value	7.59969e-07 (rank : 721)	NC score	0.876843 (rank : 369)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	805
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

M3K8_MOUSE
θ value	7.59969e-07 (rank : 722)	NC score	0.878445 (rank : 366)
Query Neighborhood Hits	1275	Target Neighborhood Hits	815	Shared Neighborhood Hits	793
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

UHMK1_HUMAN
θ value	7.59969e-07 (rank : 723)	NC score	0.880484 (rank : 359)
Query Neighborhood Hits	1275	Target Neighborhood Hits	808	Shared Neighborhood Hits	768
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

VRK1_MOUSE
θ value	7.59969e-07 (rank : 724)	NC score	0.536522 (rank : 825)
Query Neighborhood Hits	1275	Target Neighborhood Hits	583	Shared Neighborhood Hits	576
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

ACVR1_HUMAN
θ value	9.92553e-07 (rank : 725)	NC score	0.736350 (rank : 705)
Query Neighborhood Hits	1275	Target Neighborhood Hits	760	Shared Neighborhood Hits	747
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ERBB3_HUMAN
θ value	9.92553e-07 (rank : 726)	NC score	0.725447 (rank : 733)
Query Neighborhood Hits	1275	Target Neighborhood Hits	918	Shared Neighborhood Hits	777
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

BMX_MOUSE
θ value	1.29631e-06 (rank : 727)	NC score	0.788100 (rank : 603)
Query Neighborhood Hits	1275	Target Neighborhood Hits	912	Shared Neighborhood Hits	789
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

RIPK3_MOUSE
θ value	1.29631e-06 (rank : 728)	NC score	0.846471 (rank : 514)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	805
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

UHMK1_MOUSE
θ value	1.29631e-06 (rank : 729)	NC score	0.880935 (rank : 356)
Query Neighborhood Hits	1275	Target Neighborhood Hits	809	Shared Neighborhood Hits	768
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

KC1E_HUMAN
θ value	1.69304e-06 (rank : 730)	NC score	0.729507 (rank : 723)
Query Neighborhood Hits	1275	Target Neighborhood Hits	732	Shared Neighborhood Hits	724
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	1.69304e-06 (rank : 731)	NC score	0.729496 (rank : 725)
Query Neighborhood Hits	1275	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

SRPK1_HUMAN
θ value	1.69304e-06 (rank : 732)	NC score	0.659791 (rank : 798)
Query Neighborhood Hits	1275	Target Neighborhood Hits	706	Shared Neighborhood Hits	585
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

AVR2A_HUMAN
θ value	2.21117e-06 (rank : 733)	NC score	0.758885 (rank : 652)
Query Neighborhood Hits	1275	Target Neighborhood Hits	767	Shared Neighborhood Hits	757
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	2.21117e-06 (rank : 734)	NC score	0.758897 (rank : 651)
Query Neighborhood Hits	1275	Target Neighborhood Hits	767	Shared Neighborhood Hits	757
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

TTBK2_MOUSE
θ value	2.21117e-06 (rank : 735)	NC score	0.751967 (rank : 675)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	717
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

BMX_HUMAN
θ value	2.88788e-06 (rank : 736)	NC score	0.788356 (rank : 601)
Query Neighborhood Hits	1275	Target Neighborhood Hits	942	Shared Neighborhood Hits	798
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ERN2_MOUSE
θ value	2.88788e-06 (rank : 737)	NC score	0.863615 (rank : 442)
Query Neighborhood Hits	1275	Target Neighborhood Hits	825	Shared Neighborhood Hits	803
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

EPHB6_MOUSE
θ value	3.77169e-06 (rank : 738)	NC score	0.632906 (rank : 809)
Query Neighborhood Hits	1275	Target Neighborhood Hits	906	Shared Neighborhood Hits	705
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

RIPK2_HUMAN
θ value	3.77169e-06 (rank : 739)	NC score	0.793711 (rank : 592)
Query Neighborhood Hits	1275	Target Neighborhood Hits	774	Shared Neighborhood Hits	747
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

SRPK1_MOUSE
θ value	3.77169e-06 (rank : 740)	NC score	0.663886 (rank : 793)
Query Neighborhood Hits	1275	Target Neighborhood Hits	639	Shared Neighborhood Hits	572
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

TTBK2_HUMAN
θ value	3.77169e-06 (rank : 741)	NC score	0.754472 (rank : 671)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	727
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

VRK2_MOUSE
θ value	3.77169e-06 (rank : 742)	NC score	0.542667 (rank : 821)
Query Neighborhood Hits	1275	Target Neighborhood Hits	586	Shared Neighborhood Hits	578
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

MOS_MOUSE
θ value	4.92598e-06 (rank : 743)	NC score	0.866155 (rank : 430)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	818
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

NACAM_MOUSE
θ value	4.92598e-06 (rank : 744)	NC score	0.064658 (rank : 908)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1866	Shared Neighborhood Hits	364
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

SRPK2_HUMAN
θ value	4.92598e-06 (rank : 745)	NC score	0.647167 (rank : 805)
Query Neighborhood Hits	1275	Target Neighborhood Hits	664	Shared Neighborhood Hits	574
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	4.92598e-06 (rank : 746)	NC score	0.647518 (rank : 803)
Query Neighborhood Hits	1275	Target Neighborhood Hits	765	Shared Neighborhood Hits	590
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

ERN1_MOUSE
θ value	6.43352e-06 (rank : 747)	NC score	0.871128 (rank : 400)
Query Neighborhood Hits	1275	Target Neighborhood Hits	823	Shared Neighborhood Hits	801
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

RPKL1_HUMAN
θ value	6.43352e-06 (rank : 748)	NC score	0.702775 (rank : 770)
Query Neighborhood Hits	1275	Target Neighborhood Hits	708	Shared Neighborhood Hits	652
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	6.43352e-06 (rank : 749)	NC score	0.714935 (rank : 753)
Query Neighborhood Hits	1275	Target Neighborhood Hits	704	Shared Neighborhood Hits	660
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

TNK1_HUMAN
θ value	6.43352e-06 (rank : 750)	NC score	0.769691 (rank : 631)
Query Neighborhood Hits	1275	Target Neighborhood Hits	815	Shared Neighborhood Hits	775
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

GUC2D_HUMAN
θ value	1.09739e-05 (rank : 751)	NC score	0.560890 (rank : 817)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	661
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

IRAK1_HUMAN
θ value	1.09739e-05 (rank : 752)	NC score	0.791946 (rank : 595)
Query Neighborhood Hits	1275	Target Neighborhood Hits	820	Shared Neighborhood Hits	761
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TNK1_MOUSE
θ value	1.09739e-05 (rank : 753)	NC score	0.776123 (rank : 621)
Query Neighborhood Hits	1275	Target Neighborhood Hits	806	Shared Neighborhood Hits	773
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

ERN2_HUMAN
θ value	1.43324e-05 (rank : 754)	NC score	0.866458 (rank : 427)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	811
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

IRAK1_MOUSE
θ value	1.43324e-05 (rank : 755)	NC score	0.788728 (rank : 600)
Query Neighborhood Hits	1275	Target Neighborhood Hits	784	Shared Neighborhood Hits	740
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

VRK2_HUMAN
θ value	1.43324e-05 (rank : 756)	NC score	0.534589 (rank : 826)
Query Neighborhood Hits	1275	Target Neighborhood Hits	582	Shared Neighborhood Hits	564
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

ANPRA_MOUSE
θ value	1.87187e-05 (rank : 757)	NC score	0.514151 (rank : 829)
Query Neighborhood Hits	1275	Target Neighborhood Hits	600	Shared Neighborhood Hits	534
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
θ value	2.44474e-05 (rank : 758)	NC score	0.519753 (rank : 828)
Query Neighborhood Hits	1275	Target Neighborhood Hits	612	Shared Neighborhood Hits	543
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

EPHAA_HUMAN
θ value	2.44474e-05 (rank : 759)	NC score	0.639540 (rank : 808)
Query Neighborhood Hits	1275	Target Neighborhood Hits	960	Shared Neighborhood Hits	732
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_HUMAN
θ value	2.44474e-05 (rank : 760)	NC score	0.611181 (rank : 813)
Query Neighborhood Hits	1275	Target Neighborhood Hits	912	Shared Neighborhood Hits	682
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

GUC2F_HUMAN
θ value	2.44474e-05 (rank : 761)	NC score	0.614776 (rank : 812)
Query Neighborhood Hits	1275	Target Neighborhood Hits	740	Shared Neighborhood Hits	673
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

KS6C1_MOUSE
θ value	2.44474e-05 (rank : 762)	NC score	0.693081 (rank : 782)
Query Neighborhood Hits	1275	Target Neighborhood Hits	700	Shared Neighborhood Hits	633
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KSR1_MOUSE
θ value	2.44474e-05 (rank : 763)	NC score	0.807548 (rank : 556)
Query Neighborhood Hits	1275	Target Neighborhood Hits	870	Shared Neighborhood Hits	807
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

RIPK4_HUMAN
θ value	2.44474e-05 (rank : 764)	NC score	0.659794 (rank : 797)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1094	Shared Neighborhood Hits	802
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

GUC2E_MOUSE
θ value	3.19293e-05 (rank : 765)	NC score	0.539661 (rank : 822)
Query Neighborhood Hits	1275	Target Neighborhood Hits	692	Shared Neighborhood Hits	637
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2G_MOUSE
θ value	3.19293e-05 (rank : 766)	NC score	0.552358 (rank : 819)
Query Neighborhood Hits	1275	Target Neighborhood Hits	644	Shared Neighborhood Hits	579
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

KC1G1_HUMAN
θ value	3.19293e-05 (rank : 767)	NC score	0.713906 (rank : 754)
Query Neighborhood Hits	1275	Target Neighborhood Hits	708	Shared Neighborhood Hits	704
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	3.19293e-05 (rank : 768)	NC score	0.715221 (rank : 751)
Query Neighborhood Hits	1275	Target Neighborhood Hits	713	Shared Neighborhood Hits	706
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G3_HUMAN
θ value	3.19293e-05 (rank : 769)	NC score	0.710809 (rank : 760)
Query Neighborhood Hits	1275	Target Neighborhood Hits	711	Shared Neighborhood Hits	707
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KS6C1_HUMAN
θ value	3.19293e-05 (rank : 770)	NC score	0.688055 (rank : 784)
Query Neighborhood Hits	1275	Target Neighborhood Hits	682	Shared Neighborhood Hits	637
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

M3K8_HUMAN
θ value	3.19293e-05 (rank : 771)	NC score	0.877363 (rank : 367)
Query Neighborhood Hits	1275	Target Neighborhood Hits	807	Shared Neighborhood Hits	792
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

WEE1B_HUMAN
θ value	3.19293e-05 (rank : 772)	NC score	0.793970 (rank : 590)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	744
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

ACV1C_MOUSE
θ value	4.1701e-05 (rank : 773)	NC score	0.662196 (rank : 794)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	698
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

MKNK1_HUMAN
θ value	4.1701e-05 (rank : 774)	NC score	0.784908 (rank : 609)
Query Neighborhood Hits	1275	Target Neighborhood Hits	701	Shared Neighborhood Hits	688
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

STK23_HUMAN
θ value	4.1701e-05 (rank : 775)	NC score	0.647211 (rank : 804)
Query Neighborhood Hits	1275	Target Neighborhood Hits	556	Shared Neighborhood Hits	550
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	4.1701e-05 (rank : 776)	NC score	0.649086 (rank : 802)
Query Neighborhood Hits	1275	Target Neighborhood Hits	572	Shared Neighborhood Hits	556
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

MOS_HUMAN
θ value	7.1131e-05 (rank : 777)	NC score	0.863576 (rank : 444)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	817
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

TARA_HUMAN
θ value	9.29e-05 (rank : 778)	NC score	0.055659 (rank : 956)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1626	Shared Neighborhood Hits	265
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TGFR1_HUMAN
θ value	9.29e-05 (rank : 779)	NC score	0.713669 (rank : 755)
Query Neighborhood Hits	1275	Target Neighborhood Hits	755	Shared Neighborhood Hits	743
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	9.29e-05 (rank : 780)	NC score	0.713369 (rank : 756)
Query Neighborhood Hits	1275	Target Neighborhood Hits	753	Shared Neighborhood Hits	743
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

ACV1C_HUMAN
θ value	0.000121331 (rank : 781)	NC score	0.655868 (rank : 801)
Query Neighborhood Hits	1275	Target Neighborhood Hits	709	Shared Neighborhood Hits	692
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

AL2S2_HUMAN
θ value	0.000121331 (rank : 782)	NC score	0.815159 (rank : 552)
Query Neighborhood Hits	1275	Target Neighborhood Hits	727	Shared Neighborhood Hits	713
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AVR2B_HUMAN
θ value	0.000121331 (rank : 783)	NC score	0.738640 (rank : 701)
Query Neighborhood Hits	1275	Target Neighborhood Hits	748	Shared Neighborhood Hits	735
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	0.000121331 (rank : 784)	NC score	0.738652 (rank : 700)
Query Neighborhood Hits	1275	Target Neighborhood Hits	749	Shared Neighborhood Hits	735
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

KSR1_HUMAN
θ value	0.000121331 (rank : 785)	NC score	0.802944 (rank : 562)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	797
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

ACVL1_MOUSE
θ value	0.000158464 (rank : 786)	NC score	0.699047 (rank : 775)
Query Neighborhood Hits	1275	Target Neighborhood Hits	739	Shared Neighborhood Hits	729
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACV1B_HUMAN
θ value	0.00020696 (rank : 787)	NC score	0.705718 (rank : 767)
Query Neighborhood Hits	1275	Target Neighborhood Hits	753	Shared Neighborhood Hits	744
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	0.00020696 (rank : 788)	NC score	0.706012 (rank : 766)
Query Neighborhood Hits	1275	Target Neighborhood Hits	753	Shared Neighborhood Hits	743
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

RYK_MOUSE
θ value	0.00020696 (rank : 789)	NC score	0.658311 (rank : 799)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	694
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

DCC_MOUSE
θ value	0.000270298 (rank : 790)	NC score	0.070917 (rank : 890)
Query Neighborhood Hits	1275	Target Neighborhood Hits	896	Shared Neighborhood Hits	189
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

IRAK2_HUMAN
θ value	0.000270298 (rank : 791)	NC score	0.712501 (rank : 758)
Query Neighborhood Hits	1275	Target Neighborhood Hits	714	Shared Neighborhood Hits	681
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

KC1G2_MOUSE
θ value	0.000270298 (rank : 792)	NC score	0.683756 (rank : 785)
Query Neighborhood Hits	1275	Target Neighborhood Hits	695	Shared Neighborhood Hits	691
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

ANK2_HUMAN
θ value	0.00035302 (rank : 793)	NC score	0.037100 (rank : 1036)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1615	Shared Neighborhood Hits	280
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CDC7_HUMAN
θ value	0.00035302 (rank : 794)	NC score	0.755469 (rank : 666)
Query Neighborhood Hits	1275	Target Neighborhood Hits	652	Shared Neighborhood Hits	628
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

RYK_HUMAN
θ value	0.00035302 (rank : 795)	NC score	0.642045 (rank : 807)
Query Neighborhood Hits	1275	Target Neighborhood Hits	701	Shared Neighborhood Hits	682
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

STYK1_MOUSE
θ value	0.00035302 (rank : 796)	NC score	0.732331 (rank : 717)
Query Neighborhood Hits	1275	Target Neighborhood Hits	779	Shared Neighborhood Hits	759
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

ACVL1_HUMAN
θ value	0.000461057 (rank : 797)	NC score	0.677154 (rank : 788)
Query Neighborhood Hits	1275	Target Neighborhood Hits	716	Shared Neighborhood Hits	707
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

AL2S2_MOUSE
θ value	0.000461057 (rank : 798)	NC score	0.800415 (rank : 577)
Query Neighborhood Hits	1275	Target Neighborhood Hits	709	Shared Neighborhood Hits	693
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

KC1G2_HUMAN
θ value	0.000461057 (rank : 799)	NC score	0.682841 (rank : 787)
Query Neighborhood Hits	1275	Target Neighborhood Hits	693	Shared Neighborhood Hits	690
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

STK31_HUMAN
θ value	0.000461057 (rank : 800)	NC score	0.371031 (rank : 840)
Query Neighborhood Hits	1275	Target Neighborhood Hits	570	Shared Neighborhood Hits	382
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

DUET_HUMAN
θ value	0.000602161 (rank : 801)	NC score	0.790138 (rank : 597)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1220	Shared Neighborhood Hits	805
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

NPBL_MOUSE
θ value	0.000602161 (rank : 802)	NC score	0.049046 (rank : 1001)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1041	Shared Neighborhood Hits	177
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

RGS3_MOUSE
θ value	0.000602161 (rank : 803)	NC score	0.040655 (rank : 1021)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1621	Shared Neighborhood Hits	286
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TGFR2_HUMAN
θ value	0.000602161 (rank : 804)	NC score	0.741787 (rank : 696)
Query Neighborhood Hits	1275	Target Neighborhood Hits	748	Shared Neighborhood Hits	736
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	0.000602161 (rank : 805)	NC score	0.741042 (rank : 698)
Query Neighborhood Hits	1275	Target Neighborhood Hits	748	Shared Neighborhood Hits	737
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TRIB3_MOUSE
θ value	0.000602161 (rank : 806)	NC score	0.664676 (rank : 792)
Query Neighborhood Hits	1275	Target Neighborhood Hits	578	Shared Neighborhood Hits	571
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

IRAK3_MOUSE
θ value	0.000786445 (rank : 807)	NC score	0.661495 (rank : 795)
Query Neighborhood Hits	1275	Target Neighborhood Hits	628	Shared Neighborhood Hits	603
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

TOPK_MOUSE
θ value	0.000786445 (rank : 808)	NC score	0.708766 (rank : 765)
Query Neighborhood Hits	1275	Target Neighborhood Hits	618	Shared Neighborhood Hits	600
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

IWS1_HUMAN
θ value	0.00102713 (rank : 809)	NC score	0.042320 (rank : 1015)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1241	Shared Neighborhood Hits	201
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LRRK1_MOUSE
θ value	0.00102713 (rank : 810)	NC score	0.763820 (rank : 641)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1267	Shared Neighborhood Hits	805
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

NIPBL_HUMAN
θ value	0.00102713 (rank : 811)	NC score	0.054225 (rank : 966)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1311	Shared Neighborhood Hits	207
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

WEE1_HUMAN
θ value	0.00102713 (rank : 812)	NC score	0.814704 (rank : 553)
Query Neighborhood Hits	1275	Target Neighborhood Hits	777	Shared Neighborhood Hits	733
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

BCAR1_HUMAN
θ value	0.00134147 (rank : 813)	NC score	0.034489 (rank : 1041)
Query Neighborhood Hits	1275	Target Neighborhood Hits	554	Shared Neighborhood Hits	126
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

MDC1_MOUSE
θ value	0.00134147 (rank : 814)	NC score	0.058762 (rank : 936)
Query Neighborhood Hits	1275	Target Neighborhood Hits	998	Shared Neighborhood Hits	220
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

TOPK_HUMAN
θ value	0.00134147 (rank : 815)	NC score	0.700158 (rank : 774)
Query Neighborhood Hits	1275	Target Neighborhood Hits	605	Shared Neighborhood Hits	587
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

LRRK1_HUMAN
θ value	0.00175202 (rank : 816)	NC score	0.766681 (rank : 637)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1237	Shared Neighborhood Hits	800
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MLKL_MOUSE
θ value	0.00175202 (rank : 817)	NC score	0.727047 (rank : 731)
Query Neighborhood Hits	1275	Target Neighborhood Hits	707	Shared Neighborhood Hits	688
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MUC1_HUMAN
θ value	0.00175202 (rank : 818)	NC score	0.033108 (rank : 1045)
Query Neighborhood Hits	1275	Target Neighborhood Hits	975	Shared Neighborhood Hits	182
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

SON_HUMAN
θ value	0.00175202 (rank : 819)	NC score	0.049446 (rank : 1000)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1568	Shared Neighborhood Hits	296
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CDC7_MOUSE
θ value	0.00228821 (rank : 820)	NC score	0.744323 (rank : 688)
Query Neighborhood Hits	1275	Target Neighborhood Hits	641	Shared Neighborhood Hits	625
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

IRAK3_HUMAN
θ value	0.00228821 (rank : 821)	NC score	0.658013 (rank : 800)
Query Neighborhood Hits	1275	Target Neighborhood Hits	644	Shared Neighborhood Hits	624
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

MDC1_HUMAN
θ value	0.00228821 (rank : 822)	NC score	0.058846 (rank : 934)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1446	Shared Neighborhood Hits	259
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

RGS3_HUMAN
θ value	0.00228821 (rank : 823)	NC score	0.039475 (rank : 1024)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1375	Shared Neighborhood Hits	225
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

AATK_HUMAN
θ value	0.00298849 (rank : 824)	NC score	0.736987 (rank : 703)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1243	Shared Neighborhood Hits	836
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ABLM3_MOUSE
θ value	0.00298849 (rank : 825)	NC score	0.011429 (rank : 1221)
Query Neighborhood Hits	1275	Target Neighborhood Hits	294	Shared Neighborhood Hits	25
SwissProt Accessions	Q69ZX8, Q52KR1, Q6PAI7	Gene names	Ablim3, Kiaa0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

SALL1_HUMAN
θ value	0.00390308 (rank : 826)	NC score	-0.022707 (rank : 1413)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NSC2, Q99881, Q9NSC3, Q9P1R0	Gene names	SALL1, SAL1
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1).

CRSP2_HUMAN
θ value	0.00509761 (rank : 827)	NC score	0.029990 (rank : 1058)
Query Neighborhood Hits	1275	Target Neighborhood Hits	380	Shared Neighborhood Hits	87
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

NFH_MOUSE
θ value	0.00509761 (rank : 828)	NC score	0.039660 (rank : 1023)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2247	Shared Neighborhood Hits	343
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

TGON2_HUMAN
θ value	0.00509761 (rank : 829)	NC score	0.053006 (rank : 973)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1037	Shared Neighborhood Hits	195
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TXND2_MOUSE
θ value	0.00509761 (rank : 830)	NC score	0.030915 (rank : 1055)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	116
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

WEE1_MOUSE
θ value	0.00509761 (rank : 831)	NC score	0.824391 (rank : 540)
Query Neighborhood Hits	1275	Target Neighborhood Hits	794	Shared Neighborhood Hits	752
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

CEL_HUMAN
θ value	0.00665767 (rank : 832)	NC score	0.016111 (rank : 1159)
Query Neighborhood Hits	1275	Target Neighborhood Hits	896	Shared Neighborhood Hits	166
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

STK40_HUMAN
θ value	0.00665767 (rank : 833)	NC score	0.784793 (rank : 610)
Query Neighborhood Hits	1275	Target Neighborhood Hits	751	Shared Neighborhood Hits	733
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

SFRIP_HUMAN
θ value	0.00869519 (rank : 834)	NC score	0.052833 (rank : 975)
Query Neighborhood Hits	1275	Target Neighborhood Hits	530	Shared Neighborhood Hits	125
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

TARSH_HUMAN
θ value	0.00869519 (rank : 835)	NC score	0.068593 (rank : 895)
Query Neighborhood Hits	1275	Target Neighborhood Hits	768	Shared Neighborhood Hits	191
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

AATK_MOUSE
θ value	0.0113563 (rank : 836)	NC score	0.727538 (rank : 729)
Query Neighborhood Hits	1275	Target Neighborhood Hits	942	Shared Neighborhood Hits	793
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

UBQL1_MOUSE
θ value	0.0113563 (rank : 837)	NC score	0.010099 (rank : 1238)
Query Neighborhood Hits	1275	Target Neighborhood Hits	86	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R317, Q80V10, Q8C7T4, Q8C835, Q8K141, Q91VI8, Q9D0Z0, Q9QZM1	Gene names	Ubqln1, Plic1
Domain Architecture
Description	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1).

CBL_MOUSE
θ value	0.0148317 (rank : 838)	NC score	0.011072 (rank : 1227)
Query Neighborhood Hits	1275	Target Neighborhood Hits	426	Shared Neighborhood Hits	65
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

LPP_HUMAN
θ value	0.0148317 (rank : 839)	NC score	0.024927 (rank : 1082)
Query Neighborhood Hits	1275	Target Neighborhood Hits	775	Shared Neighborhood Hits	147
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

MINT_MOUSE
θ value	0.0148317 (rank : 840)	NC score	0.041155 (rank : 1019)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1514	Shared Neighborhood Hits	276
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SON_MOUSE
θ value	0.0148317 (rank : 841)	NC score	0.044063 (rank : 1011)
Query Neighborhood Hits	1275	Target Neighborhood Hits	957	Shared Neighborhood Hits	215
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SRRM2_MOUSE
θ value	0.0148317 (rank : 842)	NC score	0.078132 (rank : 882)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1470	Shared Neighborhood Hits	308
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

BCAR1_MOUSE
θ value	0.0193708 (rank : 843)	NC score	0.034769 (rank : 1040)
Query Neighborhood Hits	1275	Target Neighborhood Hits	438	Shared Neighborhood Hits	118
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NOLC1_HUMAN
θ value	0.0193708 (rank : 844)	NC score	0.047884 (rank : 1004)
Query Neighborhood Hits	1275	Target Neighborhood Hits	452	Shared Neighborhood Hits	125
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

PI3R4_MOUSE
θ value	0.0193708 (rank : 845)	NC score	0.380016 (rank : 838)
Query Neighborhood Hits	1275	Target Neighborhood Hits	535	Shared Neighborhood Hits	354
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

RBBP6_HUMAN
θ value	0.0193708 (rank : 846)	NC score	0.037895 (rank : 1033)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1135	Shared Neighborhood Hits	188
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

SELPL_MOUSE
θ value	0.0193708 (rank : 847)	NC score	0.032786 (rank : 1048)
Query Neighborhood Hits	1275	Target Neighborhood Hits	588	Shared Neighborhood Hits	134
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

TTC16_HUMAN
θ value	0.0193708 (rank : 848)	NC score	0.028525 (rank : 1066)
Query Neighborhood Hits	1275	Target Neighborhood Hits	417	Shared Neighborhood Hits	85
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

BSN_HUMAN
θ value	0.0252991 (rank : 849)	NC score	0.056414 (rank : 950)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1537	Shared Neighborhood Hits	308
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

EMSY_MOUSE
θ value	0.0252991 (rank : 850)	NC score	0.027260 (rank : 1072)
Query Neighborhood Hits	1275	Target Neighborhood Hits	294	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

IWS1_MOUSE
θ value	0.0252991 (rank : 851)	NC score	0.035743 (rank : 1037)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1258	Shared Neighborhood Hits	197
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

WEE1B_MOUSE
θ value	0.0252991 (rank : 852)	NC score	0.788793 (rank : 599)
Query Neighborhood Hits	1275	Target Neighborhood Hits	765	Shared Neighborhood Hits	731
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

PI3R4_HUMAN
θ value	0.0330416 (rank : 853)	NC score	0.368015 (rank : 841)
Query Neighborhood Hits	1275	Target Neighborhood Hits	534	Shared Neighborhood Hits	351
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

RN5A_MOUSE
θ value	0.0330416 (rank : 854)	NC score	0.356315 (rank : 842)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	612
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

STK40_MOUSE
θ value	0.0330416 (rank : 855)	NC score	0.783701 (rank : 613)
Query Neighborhood Hits	1275	Target Neighborhood Hits	751	Shared Neighborhood Hits	733
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

CN155_HUMAN
θ value	0.0431538 (rank : 856)	NC score	0.048942 (rank : 1002)
Query Neighborhood Hits	1275	Target Neighborhood Hits	385	Shared Neighborhood Hits	122
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

F8I2_MOUSE
θ value	0.0431538 (rank : 857)	NC score	0.017058 (rank : 1152)
Query Neighborhood Hits	1275	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q00558	Gene names	F8a1, F8a
Domain Architecture	No domain graphic available
Description	Factor VIII intron 22 protein (CpG island protein).

IASPP_MOUSE
θ value	0.0431538 (rank : 858)	NC score	0.047923 (rank : 1003)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1024	Shared Neighborhood Hits	188
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SYMPK_HUMAN
θ value	0.0431538 (rank : 859)	NC score	0.022671 (rank : 1099)
Query Neighborhood Hits	1275	Target Neighborhood Hits	90	Shared Neighborhood Hits	32
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

CRTC1_HUMAN
θ value	0.0563607 (rank : 860)	NC score	0.030555 (rank : 1057)
Query Neighborhood Hits	1275	Target Neighborhood Hits	319	Shared Neighborhood Hits	111
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

EP300_HUMAN
θ value	0.0563607 (rank : 861)	NC score	0.033048 (rank : 1046)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	206
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

HCFC1_HUMAN
θ value	0.0563607 (rank : 862)	NC score	0.019995 (rank : 1121)
Query Neighborhood Hits	1275	Target Neighborhood Hits	331	Shared Neighborhood Hits	79
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

PXK_MOUSE
θ value	0.0563607 (rank : 863)	NC score	0.185039 (rank : 849)
Query Neighborhood Hits	1275	Target Neighborhood Hits	320	Shared Neighborhood Hits	219
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SETBP_HUMAN
θ value	0.0563607 (rank : 864)	NC score	0.025046 (rank : 1080)
Query Neighborhood Hits	1275	Target Neighborhood Hits	305	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

TRIB3_HUMAN
θ value	0.0563607 (rank : 865)	NC score	0.630413 (rank : 810)
Query Neighborhood Hits	1275	Target Neighborhood Hits	519	Shared Neighborhood Hits	510
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

VRK3_MOUSE
θ value	0.0563607 (rank : 866)	NC score	0.286900 (rank : 845)
Query Neighborhood Hits	1275	Target Neighborhood Hits	342	Shared Neighborhood Hits	323
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

AKAP5_HUMAN
θ value	0.0736092 (rank : 867)	NC score	0.020415 (rank : 1118)
Query Neighborhood Hits	1275	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	P24588	Gene names	AKAP5, AKAP79
Domain Architecture
Description	A-kinase anchor protein 5 (A-kinase anchor protein 79 kDa) (AKAP 79) (cAMP-dependent protein kinase regulatory subunit II high affinity- binding protein) (H21).

CK024_HUMAN
θ value	0.0736092 (rank : 868)	NC score	0.043776 (rank : 1012)
Query Neighborhood Hits	1275	Target Neighborhood Hits	408	Shared Neighborhood Hits	111
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

PO6F1_MOUSE
θ value	0.0736092 (rank : 869)	NC score	0.004086 (rank : 1309)
Query Neighborhood Hits	1275	Target Neighborhood Hits	581	Shared Neighborhood Hits	92
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

COHA1_HUMAN
θ value	0.0961366 (rank : 870)	NC score	0.012836 (rank : 1204)
Query Neighborhood Hits	1275	Target Neighborhood Hits	400	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CUTL1_HUMAN
θ value	0.0961366 (rank : 871)	NC score	0.018020 (rank : 1141)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1574	Shared Neighborhood Hits	186
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

MLL3_HUMAN
θ value	0.0961366 (rank : 872)	NC score	0.028945 (rank : 1065)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1644	Shared Neighborhood Hits	271
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NPAS4_MOUSE
θ value	0.0961366 (rank : 873)	NC score	0.017104 (rank : 1151)
Query Neighborhood Hits	1275	Target Neighborhood Hits	245	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

SYNJ1_MOUSE
θ value	0.0961366 (rank : 874)	NC score	0.029172 (rank : 1063)
Query Neighborhood Hits	1275	Target Neighborhood Hits	516	Shared Neighborhood Hits	159
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

ASPP1_MOUSE
θ value	0.125558 (rank : 875)	NC score	0.045491 (rank : 1009)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1244	Shared Neighborhood Hits	226
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CD248_HUMAN
θ value	0.125558 (rank : 876)	NC score	0.012881 (rank : 1203)
Query Neighborhood Hits	1275	Target Neighborhood Hits	679	Shared Neighborhood Hits	127
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CIC_MOUSE
θ value	0.125558 (rank : 877)	NC score	0.025030 (rank : 1081)
Query Neighborhood Hits	1275	Target Neighborhood Hits	742	Shared Neighborhood Hits	176
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

GAK6_HUMAN
θ value	0.125558 (rank : 878)	NC score	0.015107 (rank : 1173)
Query Neighborhood Hits	1275	Target Neighborhood Hits	392	Shared Neighborhood Hits	87
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

RBBP6_MOUSE
θ value	0.125558 (rank : 879)	NC score	0.047218 (rank : 1006)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1014	Shared Neighborhood Hits	189
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

SEPT9_HUMAN
θ value	0.125558 (rank : 880)	NC score	0.015791 (rank : 1167)
Query Neighborhood Hits	1275	Target Neighborhood Hits	706	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SRRM1_MOUSE
θ value	0.125558 (rank : 881)	NC score	0.088016 (rank : 872)
Query Neighborhood Hits	1275	Target Neighborhood Hits	966	Shared Neighborhood Hits	252
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SVIL_HUMAN
θ value	0.125558 (rank : 882)	NC score	0.017661 (rank : 1146)
Query Neighborhood Hits	1275	Target Neighborhood Hits	232	Shared Neighborhood Hits	56
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

WDHD1_MOUSE
θ value	0.125558 (rank : 883)	NC score	-0.003892 (rank : 1385)
Query Neighborhood Hits	1275	Target Neighborhood Hits	414	Shared Neighborhood Hits	31
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

CCD45_MOUSE
θ value	0.163984 (rank : 884)	NC score	0.038473 (rank : 1031)
Query Neighborhood Hits	1275	Target Neighborhood Hits	663	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CO002_HUMAN
θ value	0.163984 (rank : 885)	NC score	0.022625 (rank : 1100)
Query Neighborhood Hits	1275	Target Neighborhood Hits	387	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

ENAM_HUMAN
θ value	0.163984 (rank : 886)	NC score	0.018184 (rank : 1140)
Query Neighborhood Hits	1275	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

FILA_HUMAN
θ value	0.163984 (rank : 887)	NC score	0.032990 (rank : 1047)
Query Neighborhood Hits	1275	Target Neighborhood Hits	685	Shared Neighborhood Hits	108
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

GP1BA_HUMAN
θ value	0.163984 (rank : 888)	NC score	-0.002022 (rank : 1373)
Query Neighborhood Hits	1275	Target Neighborhood Hits	407	Shared Neighborhood Hits	68
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

K0460_HUMAN
θ value	0.163984 (rank : 889)	NC score	0.023451 (rank : 1093)
Query Neighborhood Hits	1275	Target Neighborhood Hits	357	Shared Neighborhood Hits	89
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

K2027_HUMAN
θ value	0.163984 (rank : 890)	NC score	0.023599 (rank : 1092)
Query Neighborhood Hits	1275	Target Neighborhood Hits	194	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

SOX30_HUMAN
θ value	0.163984 (rank : 891)	NC score	0.005808 (rank : 1279)
Query Neighborhood Hits	1275	Target Neighborhood Hits	305	Shared Neighborhood Hits	65
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

VRK3_HUMAN
θ value	0.163984 (rank : 892)	NC score	0.286405 (rank : 846)
Query Neighborhood Hits	1275	Target Neighborhood Hits	349	Shared Neighborhood Hits	321
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

HNF3G_MOUSE
θ value	0.21417 (rank : 893)	NC score	-0.004958 (rank : 1390)
Query Neighborhood Hits	1275	Target Neighborhood Hits	103	Shared Neighborhood Hits	11
SwissProt Accessions	P35584	Gene names	Foxa3, Hnf3g, Tcf-3g, Tcf3g
Domain Architecture
Description	Hepatocyte nuclear factor 3-gamma (HNF-3G) (Forkhead box protein A3).

NCOA6_MOUSE
θ value	0.21417 (rank : 894)	NC score	0.047867 (rank : 1005)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1076	Shared Neighborhood Hits	235
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RHG06_HUMAN
θ value	0.21417 (rank : 895)	NC score	0.002109 (rank : 1333)
Query Neighborhood Hits	1275	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

ST5_HUMAN
θ value	0.21417 (rank : 896)	NC score	0.008009 (rank : 1254)
Query Neighborhood Hits	1275	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

TNC6B_HUMAN
θ value	0.21417 (rank : 897)	NC score	0.016050 (rank : 1160)
Query Neighborhood Hits	1275	Target Neighborhood Hits	256	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

TRI66_HUMAN
θ value	0.21417 (rank : 898)	NC score	0.008656 (rank : 1246)
Query Neighborhood Hits	1275	Target Neighborhood Hits	479	Shared Neighborhood Hits	108
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

TXLNB_HUMAN
θ value	0.21417 (rank : 899)	NC score	0.031897 (rank : 1051)
Query Neighborhood Hits	1275	Target Neighborhood Hits	912	Shared Neighborhood Hits	151
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

CCD55_MOUSE
θ value	0.279714 (rank : 900)	NC score	0.037542 (rank : 1035)
Query Neighborhood Hits	1275	Target Neighborhood Hits	519	Shared Neighborhood Hits	90
SwissProt Accessions	Q5NCR9	Gene names	Ccdc55
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 55.

CK5P2_HUMAN
θ value	0.279714 (rank : 901)	NC score	0.020575 (rank : 1115)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1433	Shared Neighborhood Hits	149
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

DDEF1_MOUSE
θ value	0.279714 (rank : 902)	NC score	0.010864 (rank : 1229)
Query Neighborhood Hits	1275	Target Neighborhood Hits	592	Shared Neighborhood Hits	104
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

GAK11_HUMAN
θ value	0.279714 (rank : 903)	NC score	0.014194 (rank : 1193)
Query Neighborhood Hits	1275	Target Neighborhood Hits	409	Shared Neighborhood Hits	86
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	0.279714 (rank : 904)	NC score	0.013831 (rank : 1195)
Query Neighborhood Hits	1275	Target Neighborhood Hits	415	Shared Neighborhood Hits	89
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GCM2_HUMAN
θ value	0.279714 (rank : 905)	NC score	0.007602 (rank : 1258)
Query Neighborhood Hits	1275	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	O75603	Gene names	GCM2, GCMB
Domain Architecture
Description	Chorion-specific transcription factor GCMb (Glial cells missing homolog 2) (GCM motif protein 2) (hGCMb).

IL3B2_MOUSE
θ value	0.279714 (rank : 906)	NC score	0.018290 (rank : 1137)
Query Neighborhood Hits	1275	Target Neighborhood Hits	372	Shared Neighborhood Hits	69
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

IPR1_MOUSE
θ value	0.279714 (rank : 907)	NC score	0.011196 (rank : 1225)
Query Neighborhood Hits	1275	Target Neighborhood Hits	65	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BVK9, Q3UCV7, Q80V00	Gene names	Ipr1, Ifi75
Domain Architecture	No domain graphic available
Description	Intracellular pathogen resistance protein 1.

NKX28_MOUSE
θ value	0.279714 (rank : 908)	NC score	-0.013111 (rank : 1407)
Query Neighborhood Hits	1275	Target Neighborhood Hits	347	Shared Neighborhood Hits	16
SwissProt Accessions	O70584	Gene names	Nkx2-8, Nkx-2.9, Nkx2-9, Nkx2h
Domain Architecture
Description	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H) (Homeobox protein Nkx-2.9).

PF21A_HUMAN
θ value	0.279714 (rank : 909)	NC score	0.005571 (rank : 1283)
Query Neighborhood Hits	1275	Target Neighborhood Hits	303	Shared Neighborhood Hits	42
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

SC24A_MOUSE
θ value	0.279714 (rank : 910)	NC score	0.015049 (rank : 1176)
Query Neighborhood Hits	1275	Target Neighborhood Hits	394	Shared Neighborhood Hits	94
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SETB1_HUMAN
θ value	0.279714 (rank : 911)	NC score	0.005506 (rank : 1284)
Query Neighborhood Hits	1275	Target Neighborhood Hits	141	Shared Neighborhood Hits	28
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

SETBP_MOUSE
θ value	0.279714 (rank : 912)	NC score	0.022068 (rank : 1106)
Query Neighborhood Hits	1275	Target Neighborhood Hits	352	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SRBP1_MOUSE
θ value	0.279714 (rank : 913)	NC score	0.012518 (rank : 1208)
Query Neighborhood Hits	1275	Target Neighborhood Hits	384	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

UBQL2_MOUSE
θ value	0.279714 (rank : 914)	NC score	0.009273 (rank : 1241)
Query Neighborhood Hits	1275	Target Neighborhood Hits	114	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZM0, Q7TSJ8, Q8VDH9	Gene names	Ubqln2, Plic2
Domain Architecture
Description	Ubiquilin-2 (Protein linking IAP with cytoskeleton 2) (PLIC-2) (Ubiquitin-like product Chap1/Dsk2) (DSK2 homolog) (Chap1).

AMHR2_HUMAN
θ value	0.365318 (rank : 915)	NC score	0.601546 (rank : 814)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	656
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

CD248_MOUSE
θ value	0.365318 (rank : 916)	NC score	0.007085 (rank : 1264)
Query Neighborhood Hits	1275	Target Neighborhood Hits	578	Shared Neighborhood Hits	96
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CI039_HUMAN
θ value	0.365318 (rank : 917)	NC score	0.027375 (rank : 1071)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1171	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CJ047_MOUSE
θ value	0.365318 (rank : 918)	NC score	0.018252 (rank : 1139)
Query Neighborhood Hits	1275	Target Neighborhood Hits	76	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C5R2, Q8R017, Q8R2Z9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf47 homolog.

FA47B_HUMAN
θ value	0.365318 (rank : 919)	NC score	0.023294 (rank : 1095)
Query Neighborhood Hits	1275	Target Neighborhood Hits	431	Shared Neighborhood Hits	102
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

FA5_HUMAN
θ value	0.365318 (rank : 920)	NC score	0.010427 (rank : 1233)
Query Neighborhood Hits	1275	Target Neighborhood Hits	172	Shared Neighborhood Hits	38
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

NOTC2_MOUSE
θ value	0.365318 (rank : 921)	NC score	-0.004795 (rank : 1388)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1069	Shared Neighborhood Hits	94
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NPAS4_HUMAN
θ value	0.365318 (rank : 922)	NC score	0.014914 (rank : 1179)
Query Neighborhood Hits	1275	Target Neighborhood Hits	214	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

PHC3_HUMAN
θ value	0.365318 (rank : 923)	NC score	0.018645 (rank : 1131)
Query Neighborhood Hits	1275	Target Neighborhood Hits	218	Shared Neighborhood Hits	69
SwissProt Accessions	Q8NDX5, Q5HYF0, Q6NSG2, Q8NFT7, Q8NFZ1, Q8TBM2, Q9H971, Q9H9I4	Gene names	PHC3, EDR3, PH3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3 (hPH3) (Homolog of polyhomeotic 3) (Early development regulatory protein 3).

PRRT3_HUMAN
θ value	0.365318 (rank : 924)	NC score	0.033383 (rank : 1044)
Query Neighborhood Hits	1275	Target Neighborhood Hits	998	Shared Neighborhood Hits	186
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RPGF1_HUMAN
θ value	0.365318 (rank : 925)	NC score	0.006340 (rank : 1272)
Query Neighborhood Hits	1275	Target Neighborhood Hits	262	Shared Neighborhood Hits	43
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RTKN_HUMAN
θ value	0.365318 (rank : 926)	NC score	0.011128 (rank : 1226)
Query Neighborhood Hits	1275	Target Neighborhood Hits	97	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BST9, Q8WVN1, Q96PT6, Q9HB05	Gene names	RTKN
Domain Architecture	No domain graphic available
Description	Rhotekin.

ZN409_HUMAN
θ value	0.365318 (rank : 927)	NC score	-0.005618 (rank : 1395)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPU6	Gene names	ZNF409, KIAA1056
Domain Architecture	No domain graphic available
Description	Zinc finger protein 409.

ACM4_HUMAN
θ value	0.47712 (rank : 928)	NC score	-0.023827 (rank : 1417)
Query Neighborhood Hits	1275	Target Neighborhood Hits	889	Shared Neighborhood Hits	11
SwissProt Accessions	P08173	Gene names	CHRM4
Domain Architecture
Description	Muscarinic acetylcholine receptor M4.

ADRM1_MOUSE
θ value	0.47712 (rank : 929)	NC score	0.015962 (rank : 1164)
Query Neighborhood Hits	1275	Target Neighborhood Hits	84	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JKV1	Gene names	Adrm1, Gp110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110) (ARM-1).

BUB1_HUMAN
θ value	0.47712 (rank : 930)	NC score	0.375955 (rank : 839)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	408
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

CENPE_HUMAN
θ value	0.47712 (rank : 931)	NC score	0.014789 (rank : 1182)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2060	Shared Neighborhood Hits	188
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

ELK4_HUMAN
θ value	0.47712 (rank : 932)	NC score	0.001294 (rank : 1346)
Query Neighborhood Hits	1275	Target Neighborhood Hits	184	Shared Neighborhood Hits	43
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

GAK2_HUMAN
θ value	0.47712 (rank : 933)	NC score	0.013647 (rank : 1197)
Query Neighborhood Hits	1275	Target Neighborhood Hits	406	Shared Neighborhood Hits	84
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

LCP2_HUMAN
θ value	0.47712 (rank : 934)	NC score	0.049998 (rank : 998)
Query Neighborhood Hits	1275	Target Neighborhood Hits	531	Shared Neighborhood Hits	148
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LPIN3_MOUSE
θ value	0.47712 (rank : 935)	NC score	0.004436 (rank : 1305)
Query Neighborhood Hits	1275	Target Neighborhood Hits	52	Shared Neighborhood Hits	8
SwissProt Accessions	Q99PI4, Q3TQ75, Q8C7R9	Gene names	Lpin3
Domain Architecture
Description	Lipin-3.

NCOA6_HUMAN
θ value	0.47712 (rank : 936)	NC score	0.042772 (rank : 1014)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1202	Shared Neighborhood Hits	254
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

RHG06_MOUSE
θ value	0.47712 (rank : 937)	NC score	0.002061 (rank : 1334)
Query Neighborhood Hits	1275	Target Neighborhood Hits	105	Shared Neighborhood Hits	11
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

SAPS1_HUMAN
θ value	0.47712 (rank : 938)	NC score	0.021262 (rank : 1111)
Query Neighborhood Hits	1275	Target Neighborhood Hits	704	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SNPC4_HUMAN
θ value	0.47712 (rank : 939)	NC score	0.026077 (rank : 1077)
Query Neighborhood Hits	1275	Target Neighborhood Hits	589	Shared Neighborhood Hits	128
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SYMPK_MOUSE
θ value	0.47712 (rank : 940)	NC score	0.020547 (rank : 1116)
Query Neighborhood Hits	1275	Target Neighborhood Hits	109	Shared Neighborhood Hits	33
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

TENS1_HUMAN
θ value	0.47712 (rank : 941)	NC score	0.038516 (rank : 1030)
Query Neighborhood Hits	1275	Target Neighborhood Hits	400	Shared Neighborhood Hits	99
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

UBP53_MOUSE
θ value	0.47712 (rank : 942)	NC score	0.008117 (rank : 1252)
Query Neighborhood Hits	1275	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

ZFHX2_HUMAN
θ value	0.47712 (rank : 943)	NC score	-0.013780 (rank : 1410)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1178	Shared Neighborhood Hits	105
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

ACM4_MOUSE
θ value	0.62314 (rank : 944)	NC score	-0.023551 (rank : 1416)
Query Neighborhood Hits	1275	Target Neighborhood Hits	894	Shared Neighborhood Hits	13
SwissProt Accessions	P32211, Q64056	Gene names	Chrm4, Chrm-4
Domain Architecture
Description	Muscarinic acetylcholine receptor M4 (Mm4 mAChR).

ADA12_MOUSE
θ value	0.62314 (rank : 945)	NC score	-0.001538 (rank : 1371)
Query Neighborhood Hits	1275	Target Neighborhood Hits	474	Shared Neighborhood Hits	83
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ANGL1_MOUSE
θ value	0.62314 (rank : 946)	NC score	-0.003552 (rank : 1384)
Query Neighborhood Hits	1275	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q640P2, Q3UQL1, Q9CZ81	Gene names	Angptl1
Domain Architecture	No domain graphic available
Description	Angiopoietin-related protein 1 precursor (Angiopoietin-like 1).

BAZ2A_MOUSE
θ value	0.62314 (rank : 947)	NC score	0.024383 (rank : 1084)
Query Neighborhood Hits	1275	Target Neighborhood Hits	744	Shared Neighborhood Hits	154
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

CBP_HUMAN
θ value	0.62314 (rank : 948)	NC score	0.032565 (rank : 1049)
Query Neighborhood Hits	1275	Target Neighborhood Hits	941	Shared Neighborhood Hits	223
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CIR_MOUSE
θ value	0.62314 (rank : 949)	NC score	0.022943 (rank : 1098)
Query Neighborhood Hits	1275	Target Neighborhood Hits	255	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

DOK2_MOUSE
θ value	0.62314 (rank : 950)	NC score	0.013784 (rank : 1196)
Query Neighborhood Hits	1275	Target Neighborhood Hits	244	Shared Neighborhood Hits	53
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

ELOA1_MOUSE
θ value	0.62314 (rank : 951)	NC score	0.014576 (rank : 1185)
Query Neighborhood Hits	1275	Target Neighborhood Hits	152	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CB77, Q80VB2, Q9R0Q5	Gene names	Tceb3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

FANCM_HUMAN
θ value	0.62314 (rank : 952)	NC score	0.000299 (rank : 1355)
Query Neighborhood Hits	1275	Target Neighborhood Hits	210	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FBLN2_MOUSE
θ value	0.62314 (rank : 953)	NC score	-0.006301 (rank : 1397)
Query Neighborhood Hits	1275	Target Neighborhood Hits	505	Shared Neighborhood Hits	59
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

FCRLA_HUMAN
θ value	0.62314 (rank : 954)	NC score	0.004180 (rank : 1308)
Query Neighborhood Hits	1275	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

FMN2_HUMAN
θ value	0.62314 (rank : 955)	NC score	0.024305 (rank : 1085)
Query Neighborhood Hits	1275	Target Neighborhood Hits	484	Shared Neighborhood Hits	133
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

GCC2_MOUSE
θ value	0.62314 (rank : 956)	NC score	0.016043 (rank : 1161)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1619	Shared Neighborhood Hits	153
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

LRBA_HUMAN
θ value	0.62314 (rank : 957)	NC score	0.005886 (rank : 1277)
Query Neighborhood Hits	1275	Target Neighborhood Hits	196	Shared Neighborhood Hits	27
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

MBB1A_HUMAN
θ value	0.62314 (rank : 958)	NC score	0.033869 (rank : 1043)
Query Neighborhood Hits	1275	Target Neighborhood Hits	665	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

MTR1L_HUMAN
θ value	0.62314 (rank : 959)	NC score	-0.022859 (rank : 1414)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1180	Shared Neighborhood Hits	72
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

NCOR2_HUMAN
θ value	0.62314 (rank : 960)	NC score	0.050520 (rank : 991)
Query Neighborhood Hits	1275	Target Neighborhood Hits	870	Shared Neighborhood Hits	209
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

PTN13_MOUSE
θ value	0.62314 (rank : 961)	NC score	-0.006372 (rank : 1399)
Query Neighborhood Hits	1275	Target Neighborhood Hits	426	Shared Neighborhood Hits	46
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

REPS2_MOUSE
θ value	0.62314 (rank : 962)	NC score	0.015085 (rank : 1174)
Query Neighborhood Hits	1275	Target Neighborhood Hits	102	Shared Neighborhood Hits	33
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

STYX_HUMAN
θ value	0.62314 (rank : 963)	NC score	-0.000257 (rank : 1363)
Query Neighborhood Hits	1275	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WUJ0, Q99850	Gene names	STYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein).

ZN645_HUMAN
θ value	0.62314 (rank : 964)	NC score	0.017701 (rank : 1144)
Query Neighborhood Hits	1275	Target Neighborhood Hits	265	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

ABLM3_HUMAN
θ value	0.813845 (rank : 965)	NC score	0.008413 (rank : 1249)
Query Neighborhood Hits	1275	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	O94929, Q658S1, Q68CI5, Q9BV32	Gene names	ABLIM3, KIAA0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

ATBF1_MOUSE
θ value	0.813845 (rank : 966)	NC score	-0.006442 (rank : 1400)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1841	Shared Neighborhood Hits	214
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CBL_HUMAN
θ value	0.813845 (rank : 967)	NC score	0.007321 (rank : 1259)
Query Neighborhood Hits	1275	Target Neighborhood Hits	353	Shared Neighborhood Hits	50
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

GAK12_HUMAN
θ value	0.813845 (rank : 968)	NC score	0.012717 (rank : 1205)
Query Neighborhood Hits	1275	Target Neighborhood Hits	374	Shared Neighborhood Hits	82
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
θ value	0.813845 (rank : 969)	NC score	0.014198 (rank : 1192)
Query Neighborhood Hits	1275	Target Neighborhood Hits	429	Shared Neighborhood Hits	91
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GON4L_HUMAN
θ value	0.813845 (rank : 970)	NC score	0.020187 (rank : 1119)
Query Neighborhood Hits	1275	Target Neighborhood Hits	555	Shared Neighborhood Hits	115
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

HEMGN_MOUSE
θ value	0.813845 (rank : 971)	NC score	0.012426 (rank : 1212)
Query Neighborhood Hits	1275	Target Neighborhood Hits	81	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ERZ0, Q3TAE6, Q80YT2, Q8CF29	Gene names	Hemgn, Ndr
Domain Architecture	No domain graphic available
Description	Hemogen (Hemopoietic gene protein) (Negative differentiation regulator protein) (mNDR).

ICB1_MOUSE
θ value	0.813845 (rank : 972)	NC score	0.007102 (rank : 1263)
Query Neighborhood Hits	1275	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	Q91YX0	Gene names	Icb1
Domain Architecture	No domain graphic available
Description	Induced by contact to basement membrane 1 protein homolog (ICB-1 protein).

IF4G1_MOUSE
θ value	0.813845 (rank : 973)	NC score	0.014268 (rank : 1191)
Query Neighborhood Hits	1275	Target Neighborhood Hits	534	Shared Neighborhood Hits	109
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

K0586_HUMAN
θ value	0.813845 (rank : 974)	NC score	0.029540 (rank : 1061)
Query Neighborhood Hits	1275	Target Neighborhood Hits	311	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

MEGF9_MOUSE
θ value	0.813845 (rank : 975)	NC score	0.014765 (rank : 1183)
Query Neighborhood Hits	1275	Target Neighborhood Hits	896	Shared Neighborhood Hits	151
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

NKG2C_HUMAN
θ value	0.813845 (rank : 976)	NC score	-0.003393 (rank : 1383)
Query Neighborhood Hits	1275	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	P26717, O43802, Q9NR42	Gene names	KLRC2, NKG2C
Domain Architecture
Description	NKG2-C type II integral membrane protein (NKG2-C-activating NK receptor) (NK cell receptor C) (CD159c antigen).

NRX2A_HUMAN
θ value	0.813845 (rank : 977)	NC score	-0.000157 (rank : 1359)
Query Neighborhood Hits	1275	Target Neighborhood Hits	614	Shared Neighborhood Hits	78
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	0.813845 (rank : 978)	NC score	0.004996 (rank : 1295)
Query Neighborhood Hits	1275	Target Neighborhood Hits	481	Shared Neighborhood Hits	70
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

NTKL_MOUSE
θ value	0.813845 (rank : 979)	NC score	0.381824 (rank : 837)
Query Neighborhood Hits	1275	Target Neighborhood Hits	326	Shared Neighborhood Hits	290
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

PCLO_HUMAN
θ value	0.813845 (rank : 980)	NC score	0.049742 (rank : 999)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2046	Shared Neighborhood Hits	364
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PHLB1_MOUSE
θ value	0.813845 (rank : 981)	NC score	0.022497 (rank : 1105)
Query Neighborhood Hits	1275	Target Neighborhood Hits	678	Shared Neighborhood Hits	114
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB2_HUMAN
θ value	0.813845 (rank : 982)	NC score	0.022578 (rank : 1102)
Query Neighborhood Hits	1275	Target Neighborhood Hits	964	Shared Neighborhood Hits	114
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PI4KB_MOUSE
θ value	0.813845 (rank : 983)	NC score	0.006755 (rank : 1268)
Query Neighborhood Hits	1275	Target Neighborhood Hits	67	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

PLEC1_HUMAN
θ value	0.813845 (rank : 984)	NC score	0.013101 (rank : 1199)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1326	Shared Neighborhood Hits	134
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

RGL1_HUMAN
θ value	0.813845 (rank : 985)	NC score	0.002546 (rank : 1325)
Query Neighborhood Hits	1275	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RIMS1_HUMAN
θ value	0.813845 (rank : 986)	NC score	0.019834 (rank : 1122)
Query Neighborhood Hits	1275	Target Neighborhood Hits	437	Shared Neighborhood Hits	82
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

RSF1_HUMAN
θ value	0.813845 (rank : 987)	NC score	0.020514 (rank : 1117)
Query Neighborhood Hits	1275	Target Neighborhood Hits	539	Shared Neighborhood Hits	100
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

SETX_HUMAN
θ value	0.813845 (rank : 988)	NC score	0.014059 (rank : 1194)
Query Neighborhood Hits	1275	Target Neighborhood Hits	368	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

ST5_MOUSE
θ value	0.813845 (rank : 989)	NC score	0.008512 (rank : 1247)
Query Neighborhood Hits	1275	Target Neighborhood Hits	126	Shared Neighborhood Hits	41
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

TARA_MOUSE
θ value	0.813845 (rank : 990)	NC score	0.039295 (rank : 1025)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1133	Shared Neighborhood Hits	208
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TEX14_MOUSE
θ value	0.813845 (rank : 991)	NC score	0.539484 (rank : 823)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1333	Shared Neighborhood Hits	695
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

U689_HUMAN
θ value	0.813845 (rank : 992)	NC score	0.012882 (rank : 1202)
Query Neighborhood Hits	1275	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q6UX39	Gene names	ames=UNQ689/PRO1329
Domain Architecture	No domain graphic available
Description	Protein UNQ689/PRO1329 precursor.

ANK3_HUMAN
θ value	1.06291 (rank : 993)	NC score	0.012647 (rank : 1207)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	144
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANR11_HUMAN
θ value	1.06291 (rank : 994)	NC score	0.025112 (rank : 1079)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1289	Shared Neighborhood Hits	192
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

BPTF_HUMAN
θ value	1.06291 (rank : 995)	NC score	0.024209 (rank : 1087)
Query Neighborhood Hits	1275	Target Neighborhood Hits	786	Shared Neighborhood Hits	178
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

CIC_HUMAN
θ value	1.06291 (rank : 996)	NC score	0.029704 (rank : 1059)
Query Neighborhood Hits	1275	Target Neighborhood Hits	992	Shared Neighborhood Hits	222
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

DMN_HUMAN
θ value	1.06291 (rank : 997)	NC score	0.005053 (rank : 1290)
Query Neighborhood Hits	1275	Target Neighborhood Hits	690	Shared Neighborhood Hits	93
SwissProt Accessions	O15061	Gene names	DMN, KIAA0353
Domain Architecture
Description	Desmuslin.

DYN3_HUMAN
θ value	1.06291 (rank : 998)	NC score	0.006066 (rank : 1274)
Query Neighborhood Hits	1275	Target Neighborhood Hits	158	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

GNAS1_MOUSE
θ value	1.06291 (rank : 999)	NC score	0.007142 (rank : 1261)
Query Neighborhood Hits	1275	Target Neighborhood Hits	651	Shared Neighborhood Hits	120
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

MAML2_HUMAN
θ value	1.06291 (rank : 1000)	NC score	0.021453 (rank : 1108)
Query Neighborhood Hits	1275	Target Neighborhood Hits	360	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

NOTC2_HUMAN
θ value	1.06291 (rank : 1001)	NC score	-0.002300 (rank : 1375)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1113	Shared Neighborhood Hits	121
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

OGFR_HUMAN
θ value	1.06291 (rank : 1002)	NC score	0.038656 (rank : 1028)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1582	Shared Neighborhood Hits	250
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PHC3_MOUSE
θ value	1.06291 (rank : 1003)	NC score	0.021793 (rank : 1107)
Query Neighborhood Hits	1275	Target Neighborhood Hits	194	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CHP6, Q3TLV5	Gene names	Phc3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3.

PLCB4_HUMAN
θ value	1.06291 (rank : 1004)	NC score	0.035094 (rank : 1039)
Query Neighborhood Hits	1275	Target Neighborhood Hits	658	Shared Neighborhood Hits	104
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

SPR1B_MOUSE
θ value	1.06291 (rank : 1005)	NC score	0.016025 (rank : 1162)
Query Neighborhood Hits	1275	Target Neighborhood Hits	395	Shared Neighborhood Hits	85
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

STYX_MOUSE
θ value	1.06291 (rank : 1006)	NC score	-0.000700 (rank : 1368)
Query Neighborhood Hits	1275	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q60969, Q3TMA3, Q60970, Q9DCF8	Gene names	Styx
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein).

TCF20_HUMAN
θ value	1.06291 (rank : 1007)	NC score	0.014496 (rank : 1187)
Query Neighborhood Hits	1275	Target Neighborhood Hits	323	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TCOF_HUMAN
θ value	1.06291 (rank : 1008)	NC score	0.032487 (rank : 1050)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	121
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

ALMS1_HUMAN
θ value	1.38821 (rank : 1009)	NC score	0.017989 (rank : 1142)
Query Neighborhood Hits	1275	Target Neighborhood Hits	356	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

ATX7_HUMAN
θ value	1.38821 (rank : 1010)	NC score	0.014399 (rank : 1188)
Query Neighborhood Hits	1275	Target Neighborhood Hits	351	Shared Neighborhood Hits	80
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

BAT2_HUMAN
θ value	1.38821 (rank : 1011)	NC score	0.041458 (rank : 1018)
Query Neighborhood Hits	1275	Target Neighborhood Hits	931	Shared Neighborhood Hits	221
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAZ2A_HUMAN
θ value	1.38821 (rank : 1012)	NC score	0.019167 (rank : 1126)
Query Neighborhood Hits	1275	Target Neighborhood Hits	780	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

BSN_MOUSE
θ value	1.38821 (rank : 1013)	NC score	0.052514 (rank : 979)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2057	Shared Neighborhood Hits	351
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

C8AP2_HUMAN
θ value	1.38821 (rank : 1014)	NC score	0.027531 (rank : 1070)
Query Neighborhood Hits	1275	Target Neighborhood Hits	548	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

EMIL2_MOUSE
θ value	1.38821 (rank : 1015)	NC score	0.002753 (rank : 1319)
Query Neighborhood Hits	1275	Target Neighborhood Hits	485	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K482	Gene names	Emilin2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Basilin).

FYB_HUMAN
θ value	1.38821 (rank : 1016)	NC score	0.023792 (rank : 1088)
Query Neighborhood Hits	1275	Target Neighborhood Hits	379	Shared Neighborhood Hits	92
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GA2L2_MOUSE
θ value	1.38821 (rank : 1017)	NC score	0.016760 (rank : 1154)
Query Neighborhood Hits	1275	Target Neighborhood Hits	395	Shared Neighborhood Hits	97
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

GOGB1_HUMAN
θ value	1.38821 (rank : 1018)	NC score	0.019746 (rank : 1123)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2297	Shared Neighborhood Hits	213
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

HSF1_MOUSE
θ value	1.38821 (rank : 1019)	NC score	0.010192 (rank : 1236)
Query Neighborhood Hits	1275	Target Neighborhood Hits	267	Shared Neighborhood Hits	55
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

JPH1_MOUSE
θ value	1.38821 (rank : 1020)	NC score	0.005052 (rank : 1291)
Query Neighborhood Hits	1275	Target Neighborhood Hits	120	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

K1802_MOUSE
θ value	1.38821 (rank : 1021)	NC score	0.014763 (rank : 1184)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1596	Shared Neighborhood Hits	233
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

NTBP1_MOUSE
θ value	1.38821 (rank : 1022)	NC score	0.017389 (rank : 1147)
Query Neighborhood Hits	1275	Target Neighborhood Hits	528	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

PER2_MOUSE
θ value	1.38821 (rank : 1023)	NC score	0.011261 (rank : 1223)
Query Neighborhood Hits	1275	Target Neighborhood Hits	325	Shared Neighborhood Hits	51
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

SETD2_HUMAN
θ value	1.38821 (rank : 1024)	NC score	0.012965 (rank : 1201)
Query Neighborhood Hits	1275	Target Neighborhood Hits	412	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SLIK4_MOUSE
θ value	1.38821 (rank : 1025)	NC score	-0.008918 (rank : 1401)
Query Neighborhood Hits	1275	Target Neighborhood Hits	292	Shared Neighborhood Hits	17
SwissProt Accessions	Q810B8, Q8BL56, Q8BWB0, Q8BYG4, Q8C056	Gene names	Slitrk4
Domain Architecture
Description	SLIT and NTRK-like protein 4 precursor.

SMRC1_HUMAN
θ value	1.38821 (rank : 1026)	NC score	0.016627 (rank : 1155)
Query Neighborhood Hits	1275	Target Neighborhood Hits	375	Shared Neighborhood Hits	92
SwissProt Accessions	Q92922, Q6P172, Q8IWH2	Gene names	SMARCC1, BAF155
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155).

SRRM2_HUMAN
θ value	1.38821 (rank : 1027)	NC score	0.073474 (rank : 885)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1296	Shared Neighborhood Hits	298
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TXND2_HUMAN
θ value	1.38821 (rank : 1028)	NC score	0.040968 (rank : 1020)
Query Neighborhood Hits	1275	Target Neighborhood Hits	793	Shared Neighborhood Hits	163
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

BAT3_HUMAN
θ value	1.81305 (rank : 1029)	NC score	0.015984 (rank : 1163)
Query Neighborhood Hits	1275	Target Neighborhood Hits	490	Shared Neighborhood Hits	97
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BCL9_HUMAN
θ value	1.81305 (rank : 1030)	NC score	0.021443 (rank : 1109)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1008	Shared Neighborhood Hits	192
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CD2_HUMAN
θ value	1.81305 (rank : 1031)	NC score	0.019074 (rank : 1128)
Query Neighborhood Hits	1275	Target Neighborhood Hits	504	Shared Neighborhood Hits	114
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CI079_HUMAN
θ value	1.81305 (rank : 1032)	NC score	0.017247 (rank : 1148)
Query Neighborhood Hits	1275	Target Neighborhood Hits	288	Shared Neighborhood Hits	74
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

CJ118_MOUSE
θ value	1.81305 (rank : 1033)	NC score	0.018411 (rank : 1134)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1132	Shared Neighborhood Hits	108
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

EVI2B_HUMAN
θ value	1.81305 (rank : 1034)	NC score	0.011024 (rank : 1228)
Query Neighborhood Hits	1275	Target Neighborhood Hits	135	Shared Neighborhood Hits	37
SwissProt Accessions	P34910	Gene names	EVI2B, EVDB
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

FOXP2_MOUSE
θ value	1.81305 (rank : 1035)	NC score	0.004710 (rank : 1301)
Query Neighborhood Hits	1275	Target Neighborhood Hits	366	Shared Neighborhood Hits	60
SwissProt Accessions	P58463, Q6PD37, Q8C4F0, Q8R441	Gene names	Foxp2
Domain Architecture
Description	Forkhead box protein P2.

FZD3_HUMAN
θ value	1.81305 (rank : 1036)	NC score	-0.003332 (rank : 1382)
Query Neighborhood Hits	1275	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NPG1	Gene names	FZD3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (hFz3).

FZD3_MOUSE
θ value	1.81305 (rank : 1037)	NC score	-0.003073 (rank : 1379)
Query Neighborhood Hits	1275	Target Neighborhood Hits	75	Shared Neighborhood Hits	5
SwissProt Accessions	Q61086	Gene names	Fzd3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (mFz3).

GON4L_MOUSE
θ value	1.81305 (rank : 1038)	NC score	0.013430 (rank : 1198)
Query Neighborhood Hits	1275	Target Neighborhood Hits	455	Shared Neighborhood Hits	93
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

HDAC7_MOUSE
θ value	1.81305 (rank : 1039)	NC score	0.000662 (rank : 1353)
Query Neighborhood Hits	1275	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72	Gene names	Hdac7a, Hdac7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

IASPP_HUMAN
θ value	1.81305 (rank : 1040)	NC score	0.050258 (rank : 993)
Query Neighborhood Hits	1275	Target Neighborhood Hits	688	Shared Neighborhood Hits	159
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ITSN1_MOUSE
θ value	1.81305 (rank : 1041)	NC score	0.050653 (rank : 990)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1669	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

K1210_HUMAN
θ value	1.81305 (rank : 1042)	NC score	0.014887 (rank : 1180)
Query Neighborhood Hits	1275	Target Neighborhood Hits	219	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

LAD1_HUMAN
θ value	1.81305 (rank : 1043)	NC score	0.028958 (rank : 1064)
Query Neighborhood Hits	1275	Target Neighborhood Hits	441	Shared Neighborhood Hits	114
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

LIPA4_HUMAN
θ value	1.81305 (rank : 1044)	NC score	0.001450 (rank : 1344)
Query Neighborhood Hits	1275	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

MKL1_MOUSE
θ value	1.81305 (rank : 1045)	NC score	0.020144 (rank : 1120)
Query Neighborhood Hits	1275	Target Neighborhood Hits	667	Shared Neighborhood Hits	131
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

OBF1_MOUSE
θ value	1.81305 (rank : 1046)	NC score	0.008848 (rank : 1245)
Query Neighborhood Hits	1275	Target Neighborhood Hits	73	Shared Neighborhood Hits	17
SwissProt Accessions	Q64693	Gene names	Pou2af1, Obf-1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (BOB1) (OCA-B).

PCQAP_HUMAN
θ value	1.81305 (rank : 1047)	NC score	0.047029 (rank : 1008)
Query Neighborhood Hits	1275	Target Neighborhood Hits	549	Shared Neighborhood Hits	156
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PELP1_MOUSE
θ value	1.81305 (rank : 1048)	NC score	0.031069 (rank : 1052)
Query Neighborhood Hits	1275	Target Neighborhood Hits	709	Shared Neighborhood Hits	158
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PP1RA_HUMAN
θ value	1.81305 (rank : 1049)	NC score	0.011644 (rank : 1218)
Query Neighborhood Hits	1275	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q96QC0, O00405	Gene names	PPP1R10, CAT53, FB19, PNUTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Phosphatase 1 nuclear targeting subunit) (MHC class I region proline- rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa) (p99).

PSL1_HUMAN
θ value	1.81305 (rank : 1050)	NC score	0.016435 (rank : 1156)
Query Neighborhood Hits	1275	Target Neighborhood Hits	650	Shared Neighborhood Hits	115
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RD23A_MOUSE
θ value	1.81305 (rank : 1051)	NC score	0.005633 (rank : 1282)
Query Neighborhood Hits	1275	Target Neighborhood Hits	84	Shared Neighborhood Hits	24
SwissProt Accessions	P54726	Gene names	Rad23a, Mhr23a
Domain Architecture
Description	UV excision repair protein RAD23 homolog A (mHR23A).

SF3B1_MOUSE
θ value	1.81305 (rank : 1052)	NC score	0.013034 (rank : 1200)
Query Neighborhood Hits	1275	Target Neighborhood Hits	352	Shared Neighborhood Hits	67
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SOX13_MOUSE
θ value	1.81305 (rank : 1053)	NC score	0.007137 (rank : 1262)
Query Neighborhood Hits	1275	Target Neighborhood Hits	495	Shared Neighborhood Hits	100
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

TCF7_MOUSE
θ value	1.81305 (rank : 1054)	NC score	-0.000635 (rank : 1367)
Query Neighborhood Hits	1275	Target Neighborhood Hits	277	Shared Neighborhood Hits	30
SwissProt Accessions	Q00417	Gene names	Tcf7, Tcf-1, Tcf1
Domain Architecture
Description	Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1).

TMC2_MOUSE
θ value	1.81305 (rank : 1055)	NC score	0.015077 (rank : 1175)
Query Neighborhood Hits	1275	Target Neighborhood Hits	249	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R4P4	Gene names	Tmc2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

ZEP2_HUMAN
θ value	1.81305 (rank : 1056)	NC score	-0.019020 (rank : 1412)
Query Neighborhood Hits	1275	Target Neighborhood Hits	937	Shared Neighborhood Hits	82
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

AKAP2_MOUSE
θ value	2.36792 (rank : 1057)	NC score	0.026722 (rank : 1074)
Query Neighborhood Hits	1275	Target Neighborhood Hits	385	Shared Neighborhood Hits	89
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

ARI4A_HUMAN
θ value	2.36792 (rank : 1058)	NC score	0.022619 (rank : 1101)
Query Neighborhood Hits	1275	Target Neighborhood Hits	434	Shared Neighborhood Hits	76
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

ATF6B_HUMAN
θ value	2.36792 (rank : 1059)	NC score	0.004922 (rank : 1296)
Query Neighborhood Hits	1275	Target Neighborhood Hits	122	Shared Neighborhood Hits	25
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

BAT3_MOUSE
θ value	2.36792 (rank : 1060)	NC score	0.016170 (rank : 1158)
Query Neighborhood Hits	1275	Target Neighborhood Hits	518	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

BCOR_HUMAN
θ value	2.36792 (rank : 1061)	NC score	0.010454 (rank : 1232)
Query Neighborhood Hits	1275	Target Neighborhood Hits	609	Shared Neighborhood Hits	93
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

CG1_HUMAN
θ value	2.36792 (rank : 1062)	NC score	0.023277 (rank : 1096)
Query Neighborhood Hits	1275	Target Neighborhood Hits	222	Shared Neighborhood Hits	70
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

CJ006_HUMAN
θ value	2.36792 (rank : 1063)	NC score	0.005029 (rank : 1294)
Query Neighborhood Hits	1275	Target Neighborhood Hits	122	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IX21, Q5W0L8, Q9NPE8	Gene names	C10orf6
Domain Architecture	No domain graphic available
Description	Protein C10orf6.

DAB1_HUMAN
θ value	2.36792 (rank : 1064)	NC score	0.007795 (rank : 1256)
Query Neighborhood Hits	1275	Target Neighborhood Hits	219	Shared Neighborhood Hits	52
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

ELOA1_HUMAN
θ value	2.36792 (rank : 1065)	NC score	0.026660 (rank : 1075)
Query Neighborhood Hits	1275	Target Neighborhood Hits	388	Shared Neighborhood Hits	74
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

FOXP1_MOUSE
θ value	2.36792 (rank : 1066)	NC score	0.001290 (rank : 1347)
Query Neighborhood Hits	1275	Target Neighborhood Hits	241	Shared Neighborhood Hits	36
SwissProt Accessions	P58462	Gene names	Foxp1
Domain Architecture
Description	Forkhead box protein P1 (Forkhead-related transcription factor 1).

IC1_MOUSE
θ value	2.36792 (rank : 1067)	NC score	-0.005442 (rank : 1394)
Query Neighborhood Hits	1275	Target Neighborhood Hits	164	Shared Neighborhood Hits	25
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

IL3RB_MOUSE
θ value	2.36792 (rank : 1068)	NC score	0.015464 (rank : 1171)
Query Neighborhood Hits	1275	Target Neighborhood Hits	355	Shared Neighborhood Hits	66
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

JIP1_MOUSE
θ value	2.36792 (rank : 1069)	NC score	0.008899 (rank : 1244)
Query Neighborhood Hits	1275	Target Neighborhood Hits	259	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JPH2_HUMAN
θ value	2.36792 (rank : 1070)	NC score	0.020700 (rank : 1114)
Query Neighborhood Hits	1275	Target Neighborhood Hits	639	Shared Neighborhood Hits	127
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

LEO1_MOUSE
θ value	2.36792 (rank : 1071)	NC score	0.012451 (rank : 1211)
Query Neighborhood Hits	1275	Target Neighborhood Hits	946	Shared Neighborhood Hits	99
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

MPP8_HUMAN
θ value	2.36792 (rank : 1072)	NC score	0.018276 (rank : 1138)
Query Neighborhood Hits	1275	Target Neighborhood Hits	948	Shared Neighborhood Hits	124
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

NCOR2_MOUSE
θ value	2.36792 (rank : 1073)	NC score	0.041821 (rank : 1016)
Query Neighborhood Hits	1275	Target Neighborhood Hits	790	Shared Neighborhood Hits	190
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NFM_MOUSE
θ value	2.36792 (rank : 1074)	NC score	0.008374 (rank : 1251)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1159	Shared Neighborhood Hits	141
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

NRIP1_HUMAN
θ value	2.36792 (rank : 1075)	NC score	0.005882 (rank : 1278)
Query Neighborhood Hits	1275	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	P48552, Q8IWE8	Gene names	NRIP1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

PDZD2_HUMAN
θ value	2.36792 (rank : 1076)	NC score	0.012295 (rank : 1213)
Query Neighborhood Hits	1275	Target Neighborhood Hits	772	Shared Neighborhood Hits	126
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PI4KB_HUMAN
θ value	2.36792 (rank : 1077)	NC score	0.006139 (rank : 1273)
Query Neighborhood Hits	1275	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

PXK_HUMAN
θ value	2.36792 (rank : 1078)	NC score	0.134278 (rank : 857)
Query Neighborhood Hits	1275	Target Neighborhood Hits	216	Shared Neighborhood Hits	148
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RGL1_MOUSE
θ value	2.36792 (rank : 1079)	NC score	0.001985 (rank : 1336)
Query Neighborhood Hits	1275	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGS12_HUMAN
θ value	2.36792 (rank : 1080)	NC score	0.000678 (rank : 1352)
Query Neighborhood Hits	1275	Target Neighborhood Hits	333	Shared Neighborhood Hits	50
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

SH22A_MOUSE
θ value	2.36792 (rank : 1081)	NC score	0.038796 (rank : 1027)
Query Neighborhood Hits	1275	Target Neighborhood Hits	179	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SNPC4_MOUSE
θ value	2.36792 (rank : 1082)	NC score	0.015881 (rank : 1165)
Query Neighborhood Hits	1275	Target Neighborhood Hits	237	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

SUSD4_MOUSE
θ value	2.36792 (rank : 1083)	NC score	-0.002845 (rank : 1377)
Query Neighborhood Hits	1275	Target Neighborhood Hits	122	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BH32, Q8VC43	Gene names	Susd4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

XKR7_MOUSE
θ value	2.36792 (rank : 1084)	NC score	0.002491 (rank : 1328)
Query Neighborhood Hits	1275	Target Neighborhood Hits	146	Shared Neighborhood Hits	23
SwissProt Accessions	Q5GH64	Gene names	Xkr7, Xrg7
Domain Architecture	No domain graphic available
Description	XK-related protein 7.

YTHD2_HUMAN
θ value	2.36792 (rank : 1085)	NC score	0.001714 (rank : 1341)
Query Neighborhood Hits	1275	Target Neighborhood Hits	89	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y5A9, Q5VSZ9, Q8TDH0, Q9BUJ5	Gene names	YTHDF2, HGRG8
Domain Architecture
Description	YTH domain family protein 2 (High-glucose-regulated protein 8) (NY- REN-2 antigen) (CLL-associated antigen KW-14).

3BP2_HUMAN
θ value	3.0926 (rank : 1086)	NC score	0.018560 (rank : 1132)
Query Neighborhood Hits	1275	Target Neighborhood Hits	296	Shared Neighborhood Hits	65
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

AGRIN_HUMAN
θ value	3.0926 (rank : 1087)	NC score	-0.003032 (rank : 1378)
Query Neighborhood Hits	1275	Target Neighborhood Hits	582	Shared Neighborhood Hits	65
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

AHTF1_HUMAN
θ value	3.0926 (rank : 1088)	NC score	0.010579 (rank : 1231)
Query Neighborhood Hits	1275	Target Neighborhood Hits	286	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WYP5, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6	Gene names	AHCTF1, ELYS, TMBS62
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

AMFR2_HUMAN
θ value	3.0926 (rank : 1089)	NC score	-0.004878 (rank : 1389)
Query Neighborhood Hits	1275	Target Neighborhood Hits	219	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

ARI5B_HUMAN
θ value	3.0926 (rank : 1090)	NC score	0.017235 (rank : 1149)
Query Neighborhood Hits	1275	Target Neighborhood Hits	328	Shared Neighborhood Hits	65
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

ATX2L_MOUSE
θ value	3.0926 (rank : 1091)	NC score	0.028079 (rank : 1067)
Query Neighborhood Hits	1275	Target Neighborhood Hits	401	Shared Neighborhood Hits	120
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

CO039_HUMAN
θ value	3.0926 (rank : 1092)	NC score	0.023723 (rank : 1090)
Query Neighborhood Hits	1275	Target Neighborhood Hits	264	Shared Neighborhood Hits	87
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CO039_MOUSE
θ value	3.0926 (rank : 1093)	NC score	0.027084 (rank : 1073)
Query Neighborhood Hits	1275	Target Neighborhood Hits	445	Shared Neighborhood Hits	128
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

EXO1_MOUSE
θ value	3.0926 (rank : 1094)	NC score	0.004538 (rank : 1304)
Query Neighborhood Hits	1275	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QZ11, Q3TLM4, Q923A5	Gene names	Exo1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (mExo1) (Exonuclease I).

GAK1_HUMAN
θ value	3.0926 (rank : 1095)	NC score	0.009511 (rank : 1239)
Query Neighborhood Hits	1275	Target Neighborhood Hits	268	Shared Neighborhood Hits	60
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HCFC1_MOUSE
θ value	3.0926 (rank : 1096)	NC score	0.018313 (rank : 1136)
Query Neighborhood Hits	1275	Target Neighborhood Hits	348	Shared Neighborhood Hits	79
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

LRC46_HUMAN
θ value	3.0926 (rank : 1097)	NC score	-0.002165 (rank : 1374)
Query Neighborhood Hits	1275	Target Neighborhood Hits	181	Shared Neighborhood Hits	15
SwissProt Accessions	Q96FV0	Gene names	LRRC46
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 46.

MILK1_MOUSE
θ value	3.0926 (rank : 1098)	NC score	0.023775 (rank : 1089)
Query Neighborhood Hits	1275	Target Neighborhood Hits	788	Shared Neighborhood Hits	175
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MLL2_HUMAN
θ value	3.0926 (rank : 1099)	NC score	0.038371 (rank : 1032)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1788	Shared Neighborhood Hits	315
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MYO9B_HUMAN
θ value	3.0926 (rank : 1100)	NC score	0.027891 (rank : 1069)
Query Neighborhood Hits	1275	Target Neighborhood Hits	641	Shared Neighborhood Hits	149
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NBEA_HUMAN
θ value	3.0926 (rank : 1101)	NC score	0.001020 (rank : 1351)
Query Neighborhood Hits	1275	Target Neighborhood Hits	186	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NFM_HUMAN
θ value	3.0926 (rank : 1102)	NC score	0.012096 (rank : 1217)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1328	Shared Neighborhood Hits	198
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

PGBM_MOUSE
θ value	3.0926 (rank : 1103)	NC score	0.029534 (rank : 1062)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1073	Shared Neighborhood Hits	104
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

PINK1_HUMAN
θ value	3.0926 (rank : 1104)	NC score	0.725444 (rank : 734)
Query Neighborhood Hits	1275	Target Neighborhood Hits	741	Shared Neighborhood Hits	713
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

RAD9B_MOUSE
θ value	3.0926 (rank : 1105)	NC score	0.002660 (rank : 1321)
Query Neighborhood Hits	1275	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q6WBX7	Gene names	Rad9b
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint control protein RAD9B homolog (RAD9 homolog B) (mRAD9B).

RTEL1_HUMAN
θ value	3.0926 (rank : 1106)	NC score	0.003835 (rank : 1312)
Query Neighborhood Hits	1275	Target Neighborhood Hits	116	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

WIRE_MOUSE
θ value	3.0926 (rank : 1107)	NC score	0.034132 (rank : 1042)
Query Neighborhood Hits	1275	Target Neighborhood Hits	310	Shared Neighborhood Hits	115
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

ZN445_MOUSE
θ value	3.0926 (rank : 1108)	NC score	-0.025860 (rank : 1418)
Query Neighborhood Hits	1275	Target Neighborhood Hits	760	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R2V3, Q8K216	Gene names	Znf445, Zfp445
Domain Architecture
Description	Zinc finger protein 445.

4ET_MOUSE
θ value	4.03905 (rank : 1109)	NC score	0.004650 (rank : 1303)
Query Neighborhood Hits	1275	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EST3, Q9CSS3	Gene names	Eif4enif1, Clast4
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

ATX2L_HUMAN
θ value	4.03905 (rank : 1110)	NC score	0.031027 (rank : 1054)
Query Neighborhood Hits	1275	Target Neighborhood Hits	443	Shared Neighborhood Hits	140
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

BAG3_MOUSE
θ value	4.03905 (rank : 1111)	NC score	0.019631 (rank : 1124)
Query Neighborhood Hits	1275	Target Neighborhood Hits	513	Shared Neighborhood Hits	137
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

COHA1_MOUSE
θ value	4.03905 (rank : 1112)	NC score	0.007745 (rank : 1257)
Query Neighborhood Hits	1275	Target Neighborhood Hits	414	Shared Neighborhood Hits	79
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

CSKI1_MOUSE
θ value	4.03905 (rank : 1113)	NC score	0.042873 (rank : 1013)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1031	Shared Neighborhood Hits	224
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CUTL1_MOUSE
θ value	4.03905 (rank : 1114)	NC score	0.018538 (rank : 1133)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1620	Shared Neighborhood Hits	198
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

DOT1L_HUMAN
θ value	4.03905 (rank : 1115)	NC score	0.025940 (rank : 1078)
Query Neighborhood Hits	1275	Target Neighborhood Hits	660	Shared Neighborhood Hits	142
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

FA47A_HUMAN
θ value	4.03905 (rank : 1116)	NC score	0.029589 (rank : 1060)
Query Neighborhood Hits	1275	Target Neighborhood Hits	451	Shared Neighborhood Hits	120
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

G3BP2_HUMAN
θ value	4.03905 (rank : 1117)	NC score	-0.000942 (rank : 1369)
Query Neighborhood Hits	1275	Target Neighborhood Hits	260	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

IF4G3_MOUSE
θ value	4.03905 (rank : 1118)	NC score	0.010185 (rank : 1237)
Query Neighborhood Hits	1275	Target Neighborhood Hits	279	Shared Neighborhood Hits	74
SwissProt Accessions	Q80XI3, Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0	Gene names	Eif4g3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

K1024_MOUSE
θ value	4.03905 (rank : 1119)	NC score	0.003289 (rank : 1316)
Query Neighborhood Hits	1275	Target Neighborhood Hits	57	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3V7, Q69ZS9	Gene names	Kiaa1024
Domain Architecture
Description	UPF0258 protein KIAA1024 (Protein DD1).

KLF17_HUMAN
θ value	4.03905 (rank : 1120)	NC score	-0.023242 (rank : 1415)
Query Neighborhood Hits	1275	Target Neighborhood Hits	882	Shared Neighborhood Hits	66
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

LAD1_MOUSE
θ value	4.03905 (rank : 1121)	NC score	0.037658 (rank : 1034)
Query Neighborhood Hits	1275	Target Neighborhood Hits	391	Shared Neighborhood Hits	115
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LIPA3_HUMAN
θ value	4.03905 (rank : 1122)	NC score	0.011307 (rank : 1222)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	96
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

MAGI2_MOUSE
θ value	4.03905 (rank : 1123)	NC score	0.007019 (rank : 1265)
Query Neighborhood Hits	1275	Target Neighborhood Hits	370	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MMAC_HUMAN
θ value	4.03905 (rank : 1124)	NC score	0.004753 (rank : 1298)
Query Neighborhood Hits	1275	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4U1, Q5T157, Q9BRQ7	Gene names	MMACHC
Domain Architecture	No domain graphic available
Description	Methylmalonic aciduria and homocystinuria type C protein.

MUC5B_HUMAN
θ value	4.03905 (rank : 1125)	NC score	0.019119 (rank : 1127)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1020	Shared Neighborhood Hits	164
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

MYCB2_HUMAN
θ value	4.03905 (rank : 1126)	NC score	0.019336 (rank : 1125)
Query Neighborhood Hits	1275	Target Neighborhood Hits	390	Shared Neighborhood Hits	79
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYO15_HUMAN
θ value	4.03905 (rank : 1127)	NC score	0.015253 (rank : 1172)
Query Neighborhood Hits	1275	Target Neighborhood Hits	671	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NEBU_HUMAN
θ value	4.03905 (rank : 1128)	NC score	0.021392 (rank : 1110)
Query Neighborhood Hits	1275	Target Neighborhood Hits	420	Shared Neighborhood Hits	70
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NOVA1_HUMAN
θ value	4.03905 (rank : 1129)	NC score	-0.000003 (rank : 1357)
Query Neighborhood Hits	1275	Target Neighborhood Hits	50	Shared Neighborhood Hits	7
SwissProt Accessions	P51513	Gene names	NOVA1
Domain Architecture
Description	RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1).

NRBF2_HUMAN
θ value	4.03905 (rank : 1130)	NC score	0.005773 (rank : 1280)
Query Neighborhood Hits	1275	Target Neighborhood Hits	122	Shared Neighborhood Hits	23
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

NUP53_HUMAN
θ value	4.03905 (rank : 1131)	NC score	0.005967 (rank : 1276)
Query Neighborhood Hits	1275	Target Neighborhood Hits	156	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

PK1L1_HUMAN
θ value	4.03905 (rank : 1132)	NC score	0.005214 (rank : 1287)
Query Neighborhood Hits	1275	Target Neighborhood Hits	140	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

PRKDC_MOUSE
θ value	4.03905 (rank : 1133)	NC score	-0.000229 (rank : 1362)
Query Neighborhood Hits	1275	Target Neighborhood Hits	92	Shared Neighborhood Hits	16
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

RAD50_HUMAN
θ value	4.03905 (rank : 1134)	NC score	0.016343 (rank : 1157)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1317	Shared Neighborhood Hits	133
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

SREC2_MOUSE
θ value	4.03905 (rank : 1135)	NC score	0.005039 (rank : 1292)
Query Neighborhood Hits	1275	Target Neighborhood Hits	605	Shared Neighborhood Hits	95
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

TPO_MOUSE
θ value	4.03905 (rank : 1136)	NC score	0.007975 (rank : 1255)
Query Neighborhood Hits	1275	Target Neighborhood Hits	258	Shared Neighborhood Hits	45
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

TRIB1_HUMAN
θ value	4.03905 (rank : 1137)	NC score	0.673477 (rank : 790)
Query Neighborhood Hits	1275	Target Neighborhood Hits	598	Shared Neighborhood Hits	579
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

WIRE_HUMAN
θ value	4.03905 (rank : 1138)	NC score	0.038563 (rank : 1029)
Query Neighborhood Hits	1275	Target Neighborhood Hits	329	Shared Neighborhood Hits	132
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

YAP1_HUMAN
θ value	4.03905 (rank : 1139)	NC score	0.008013 (rank : 1253)
Query Neighborhood Hits	1275	Target Neighborhood Hits	173	Shared Neighborhood Hits	51
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ZCHC7_HUMAN
θ value	4.03905 (rank : 1140)	NC score	0.004857 (rank : 1297)
Query Neighborhood Hits	1275	Target Neighborhood Hits	73	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N3Z6, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0	Gene names	ZCCHC7
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 7.

ANR35_HUMAN
θ value	5.27518 (rank : 1141)	NC score	0.006702 (rank : 1269)
Query Neighborhood Hits	1275	Target Neighborhood Hits	784	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

APBB2_MOUSE
θ value	5.27518 (rank : 1142)	NC score	0.001704 (rank : 1342)
Query Neighborhood Hits	1275	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

B3A3_MOUSE
θ value	5.27518 (rank : 1143)	NC score	-0.000194 (rank : 1360)
Query Neighborhood Hits	1275	Target Neighborhood Hits	112	Shared Neighborhood Hits	26
SwissProt Accessions	P16283	Gene names	Slc4a3, Ae3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3).

BPAEA_MOUSE
θ value	5.27518 (rank : 1144)	NC score	0.016799 (rank : 1153)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1480	Shared Neighborhood Hits	148
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CABIN_HUMAN
θ value	5.27518 (rank : 1145)	NC score	0.022559 (rank : 1104)
Query Neighborhood Hits	1275	Target Neighborhood Hits	490	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CAC1A_MOUSE
θ value	5.27518 (rank : 1146)	NC score	-0.003222 (rank : 1381)
Query Neighborhood Hits	1275	Target Neighborhood Hits	267	Shared Neighborhood Hits	46
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAP1_MOUSE
θ value	5.27518 (rank : 1147)	NC score	0.001106 (rank : 1348)
Query Neighborhood Hits	1275	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	P40124	Gene names	Cap1, Cap
Domain Architecture
Description	Adenylyl cyclase-associated protein 1 (CAP 1).

CB017_MOUSE
θ value	5.27518 (rank : 1148)	NC score	0.010591 (rank : 1230)
Query Neighborhood Hits	1275	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	Q6NS82, Q3TA48, Q8BSD3, Q8CHY1, Q8R0Q3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf17 homolog.

CCM2_MOUSE
θ value	5.27518 (rank : 1149)	NC score	0.002774 (rank : 1318)
Query Neighborhood Hits	1275	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K2Y9	Gene names	Ccm2, Osm
Domain Architecture	No domain graphic available
Description	Malcavernin (Cerebral cavernous malformations protein 2 homolog) (Osmosensing scaffold for MEKK3).

CEBPD_HUMAN
θ value	5.27518 (rank : 1150)	NC score	0.004734 (rank : 1300)
Query Neighborhood Hits	1275	Target Neighborhood Hits	135	Shared Neighborhood Hits	28
SwissProt Accessions	P49716, Q14937	Gene names	CEBPD
Domain Architecture
Description	CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF- IL6-beta) (NF-IL6-beta).

CEBPE_HUMAN
θ value	5.27518 (rank : 1151)	NC score	0.001319 (rank : 1345)
Query Neighborhood Hits	1275	Target Neighborhood Hits	236	Shared Neighborhood Hits	30
SwissProt Accessions	Q15744, Q15745, Q8IYI2, Q99803	Gene names	CEBPE
Domain Architecture
Description	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon).

CK5P2_MOUSE
θ value	5.27518 (rank : 1152)	NC score	0.018808 (rank : 1130)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1151	Shared Neighborhood Hits	126
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CLMN_MOUSE
θ value	5.27518 (rank : 1153)	NC score	-0.000198 (rank : 1361)
Query Neighborhood Hits	1275	Target Neighborhood Hits	180	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

CUTL2_MOUSE
θ value	5.27518 (rank : 1154)	NC score	0.006033 (rank : 1275)
Query Neighborhood Hits	1275	Target Neighborhood Hits	771	Shared Neighborhood Hits	118
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

DAB2_HUMAN
θ value	5.27518 (rank : 1155)	NC score	0.005203 (rank : 1288)
Query Neighborhood Hits	1275	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

DCP1A_HUMAN
θ value	5.27518 (rank : 1156)	NC score	0.017120 (rank : 1150)
Query Neighborhood Hits	1275	Target Neighborhood Hits	228	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

EYA3_MOUSE
θ value	5.27518 (rank : 1157)	NC score	0.000002 (rank : 1356)
Query Neighborhood Hits	1275	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	P97480, P97768	Gene names	Eya3
Domain Architecture
Description	Eyes absent homolog 3 (EC 3.1.3.48).

GAB2_MOUSE
θ value	5.27518 (rank : 1158)	NC score	0.011540 (rank : 1220)
Query Neighborhood Hits	1275	Target Neighborhood Hits	220	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

ILDR1_HUMAN
θ value	5.27518 (rank : 1159)	NC score	0.002400 (rank : 1330)
Query Neighborhood Hits	1275	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q86SU0, Q6ZP61, Q7Z578	Gene names	ILDR1
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain-containing receptor 1 precursor.

IP3KA_HUMAN
θ value	5.27518 (rank : 1160)	NC score	0.002375 (rank : 1331)
Query Neighborhood Hits	1275	Target Neighborhood Hits	60	Shared Neighborhood Hits	10
SwissProt Accessions	P23677, Q8TAN3	Gene names	ITPKA
Domain Architecture
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

K0226_MOUSE
θ value	5.27518 (rank : 1161)	NC score	0.001883 (rank : 1338)
Query Neighborhood Hits	1275	Target Neighborhood Hits	59	Shared Neighborhood Hits	10
SwissProt Accessions	Q80U62, Q3TAX3, Q3TDF7, Q3TDU2, Q6P9T7, Q6PG18, Q8BMP7, Q8BY22	Gene names	Kiaa0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

K0831_MOUSE
θ value	5.27518 (rank : 1162)	NC score	0.014537 (rank : 1186)
Query Neighborhood Hits	1275	Target Neighborhood Hits	277	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CDJ3, Q69ZY1, Q6PFY6, Q8C6N0, Q8R3M3	Gene names	Kiaa0831, D14Ertd436e
Domain Architecture	No domain graphic available
Description	Protein KIAA0831.

KCNQ5_HUMAN
θ value	5.27518 (rank : 1163)	NC score	-0.003132 (rank : 1380)
Query Neighborhood Hits	1275	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

KI67_HUMAN
θ value	5.27518 (rank : 1164)	NC score	0.031063 (rank : 1053)
Query Neighborhood Hits	1275	Target Neighborhood Hits	581	Shared Neighborhood Hits	120
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

KLF3_MOUSE
θ value	5.27518 (rank : 1165)	NC score	-0.025985 (rank : 1419)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	19
SwissProt Accessions	Q60980	Gene names	Klf3, Bklf
Domain Architecture
Description	Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2).

LR37A_HUMAN
θ value	5.27518 (rank : 1166)	NC score	0.014938 (rank : 1178)
Query Neighborhood Hits	1275	Target Neighborhood Hits	720	Shared Neighborhood Hits	154
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

LYPD3_HUMAN
θ value	5.27518 (rank : 1167)	NC score	0.003039 (rank : 1317)
Query Neighborhood Hits	1275	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	O95274, Q9UJ74	Gene names	LYPD3, C4.4A
Domain Architecture	No domain graphic available
Description	Ly6/PLAUR domain-containing protein 3 precursor (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4).

MKL2_MOUSE
θ value	5.27518 (rank : 1168)	NC score	0.006603 (rank : 1270)
Query Neighborhood Hits	1275	Target Neighborhood Hits	269	Shared Neighborhood Hits	59
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

MYO9B_MOUSE
θ value	5.27518 (rank : 1169)	NC score	0.023450 (rank : 1094)
Query Neighborhood Hits	1275	Target Neighborhood Hits	311	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NOL7_HUMAN
θ value	5.27518 (rank : 1170)	NC score	0.004737 (rank : 1299)
Query Neighborhood Hits	1275	Target Neighborhood Hits	39	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UMY1, Q5T297, Q9Y3U7	Gene names	NOL7, C6orf90, NOP27
Domain Architecture	No domain graphic available
Description	Nucleolar protein 7 (Nucleolar protein of 27 kDa).

PAX3_MOUSE
θ value	5.27518 (rank : 1171)	NC score	-0.012399 (rank : 1405)
Query Neighborhood Hits	1275	Target Neighborhood Hits	478	Shared Neighborhood Hits	47
SwissProt Accessions	P24610, Q3UFQ9, Q8BRE7, Q9CXI6	Gene names	Pax3, Pax-3
Domain Architecture
Description	Paired box protein Pax-3.

PCLO_MOUSE
θ value	5.27518 (rank : 1172)	NC score	0.047094 (rank : 1007)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2275	Shared Neighborhood Hits	378
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PO6F2_HUMAN
θ value	5.27518 (rank : 1173)	NC score	0.002507 (rank : 1327)
Query Neighborhood Hits	1275	Target Neighborhood Hits	618	Shared Neighborhood Hits	118
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

RC3H1_HUMAN
θ value	5.27518 (rank : 1174)	NC score	0.001515 (rank : 1343)
Query Neighborhood Hits	1275	Target Neighborhood Hits	433	Shared Neighborhood Hits	64
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RHBD3_MOUSE
θ value	5.27518 (rank : 1175)	NC score	0.002750 (rank : 1320)
Query Neighborhood Hits	1275	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BP97, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7	Gene names	Rhbdd3
Domain Architecture	No domain graphic available
Description	Rhomboid domain-containing protein 3.

RUFY1_MOUSE
θ value	5.27518 (rank : 1176)	NC score	0.010369 (rank : 1234)
Query Neighborhood Hits	1275	Target Neighborhood Hits	765	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

SFRS6_HUMAN
θ value	5.27518 (rank : 1177)	NC score	-0.001527 (rank : 1370)
Query Neighborhood Hits	1275	Target Neighborhood Hits	247	Shared Neighborhood Hits	37
SwissProt Accessions	Q13247, Q13244, Q13245, Q96J06, Q9UJB8, Q9Y3N7	Gene names	SFRS6, SRP55
Domain Architecture
Description	Splicing factor, arginine/serine-rich 6 (Pre-mRNA-splicing factor SRP55).

SL9A5_HUMAN
θ value	5.27518 (rank : 1178)	NC score	-0.000525 (rank : 1366)
Query Neighborhood Hits	1275	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	Q14940, Q9Y626	Gene names	SLC9A5, NHE5
Domain Architecture
Description	Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5).

SMC1A_HUMAN
θ value	5.27518 (rank : 1179)	NC score	0.019031 (rank : 1129)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1346	Shared Neighborhood Hits	134
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SMC1A_MOUSE
θ value	5.27518 (rank : 1180)	NC score	0.021012 (rank : 1113)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1384	Shared Neighborhood Hits	138
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SYNE2_HUMAN
θ value	5.27518 (rank : 1181)	NC score	0.006487 (rank : 1271)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1323	Shared Neighborhood Hits	120
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TM55B_MOUSE
θ value	5.27518 (rank : 1182)	NC score	0.001090 (rank : 1349)
Query Neighborhood Hits	1275	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TWL2	Gene names	Tmem55b
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55B (EC 3.1.3.-) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase I).

TRIB1_MOUSE
θ value	5.27518 (rank : 1183)	NC score	0.672559 (rank : 791)
Query Neighborhood Hits	1275	Target Neighborhood Hits	593	Shared Neighborhood Hits	581
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TTLL4_MOUSE
θ value	5.27518 (rank : 1184)	NC score	0.002419 (rank : 1329)
Query Neighborhood Hits	1275	Target Neighborhood Hits	103	Shared Neighborhood Hits	26
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

YLPM1_HUMAN
θ value	5.27518 (rank : 1185)	NC score	0.035372 (rank : 1038)
Query Neighborhood Hits	1275	Target Neighborhood Hits	670	Shared Neighborhood Hits	183
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ZN395_HUMAN
θ value	5.27518 (rank : 1186)	NC score	0.005308 (rank : 1286)
Query Neighborhood Hits	1275	Target Neighborhood Hits	64	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H8N7, Q6F6H2, Q9BY72, Q9NPB2, Q9NS57, Q9NS58, Q9NS59	Gene names	ZNF395, HDBP2, PBF
Domain Architecture	No domain graphic available
Description	Zinc finger protein 395 (Papillomavirus-binding factor) (Papillomavirus regulatory factor 1) (PRF-1) (Huntington disease gene regulatory region-binding protein 2) (HDBP-2) (HD gene regulatory region-binding protein 2) (HD-regulating factor 2) (HDRF-2).

ZN567_HUMAN
θ value	5.27518 (rank : 1187)	NC score	-0.026557 (rank : 1420)
Query Neighborhood Hits	1275	Target Neighborhood Hits	769	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N184, Q6N044	Gene names	ZNF567
Domain Architecture	No domain graphic available
Description	Zinc finger protein 567.

ADA15_MOUSE
θ value	6.88961 (rank : 1188)	NC score	-0.006359 (rank : 1398)
Query Neighborhood Hits	1275	Target Neighborhood Hits	324	Shared Neighborhood Hits	39
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

AL2S4_MOUSE
θ value	6.88961 (rank : 1189)	NC score	0.012686 (rank : 1206)
Query Neighborhood Hits	1275	Target Neighborhood Hits	193	Shared Neighborhood Hits	49
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

ASPP2_HUMAN
θ value	6.88961 (rank : 1190)	NC score	0.041727 (rank : 1017)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1156	Shared Neighborhood Hits	204
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ATBF1_HUMAN
θ value	6.88961 (rank : 1191)	NC score	-0.014804 (rank : 1411)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1547	Shared Neighborhood Hits	164
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CABYR_MOUSE
θ value	6.88961 (rank : 1192)	NC score	0.005403 (rank : 1285)
Query Neighborhood Hits	1275	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D424, Q91Y41, Q91Y42	Gene names	Cabyr, Cbp86
Domain Architecture	No domain graphic available
Description	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium- binding protein 86) (Testis-specific calcium-binding protein CBP86).

CCM2_HUMAN
θ value	6.88961 (rank : 1193)	NC score	0.002526 (rank : 1326)
Query Neighborhood Hits	1275	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BSQ5, Q71RE5, Q8TAT4	Gene names	CCM2, C7orf22
Domain Architecture	No domain graphic available
Description	Malcavernin (Cerebral cavernous malformations 2 protein).

CEP35_HUMAN
θ value	6.88961 (rank : 1194)	NC score	0.026616 (rank : 1076)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	129
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CGRE1_MOUSE
θ value	6.88961 (rank : 1195)	NC score	0.010292 (rank : 1235)
Query Neighborhood Hits	1275	Target Neighborhood Hits	173	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R1U2, Q9D1K1	Gene names	Cgref1, Cgr11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

DMRT1_MOUSE
θ value	6.88961 (rank : 1196)	NC score	0.000610 (rank : 1354)
Query Neighborhood Hits	1275	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZ59, Q9QZ37, Q9QZA4	Gene names	Dmrt1
Domain Architecture
Description	Doublesex- and mab-3-related transcription factor 1.

EP15R_MOUSE
θ value	6.88961 (rank : 1197)	NC score	0.012502 (rank : 1210)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1135	Shared Neighborhood Hits	129
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

FA13C_MOUSE
θ value	6.88961 (rank : 1198)	NC score	0.001896 (rank : 1337)
Query Neighborhood Hits	1275	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBR2	Gene names	Fam13c1
Domain Architecture	No domain graphic available
Description	Protein FAM13C1.

FADD_MOUSE
θ value	6.88961 (rank : 1199)	NC score	0.011546 (rank : 1219)
Query Neighborhood Hits	1275	Target Neighborhood Hits	23	Shared Neighborhood Hits	6
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

FOXP2_HUMAN
θ value	6.88961 (rank : 1200)	NC score	0.004230 (rank : 1306)
Query Neighborhood Hits	1275	Target Neighborhood Hits	366	Shared Neighborhood Hits	60
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

GAB1_MOUSE
θ value	6.88961 (rank : 1201)	NC score	0.007187 (rank : 1260)
Query Neighborhood Hits	1275	Target Neighborhood Hits	233	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAK10_HUMAN
θ value	6.88961 (rank : 1202)	NC score	0.012237 (rank : 1214)
Query Neighborhood Hits	1275	Target Neighborhood Hits	289	Shared Neighborhood Hits	68
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GP156_MOUSE
θ value	6.88961 (rank : 1203)	NC score	0.002005 (rank : 1335)
Query Neighborhood Hits	1275	Target Neighborhood Hits	95	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PCP7, Q8K452	Gene names	Gpr156, Gababl
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor).

HIRP3_HUMAN
θ value	6.88961 (rank : 1204)	NC score	0.023687 (rank : 1091)
Query Neighborhood Hits	1275	Target Neighborhood Hits	323	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

HRX_HUMAN
θ value	6.88961 (rank : 1205)	NC score	0.012181 (rank : 1215)
Query Neighborhood Hits	1275	Target Neighborhood Hits	825	Shared Neighborhood Hits	167
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

JOSD3_MOUSE
θ value	6.88961 (rank : 1206)	NC score	0.003398 (rank : 1315)
Query Neighborhood Hits	1275	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D4V4, Q149X7, Q8C7I5, Q9CZG0, Q9D5U6	Gene names	Josd3
Domain Architecture	No domain graphic available
Description	Protein JOSD3.

KMHN1_HUMAN
θ value	6.88961 (rank : 1207)	NC score	0.015738 (rank : 1168)
Query Neighborhood Hits	1275	Target Neighborhood Hits	950	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

KTN1_MOUSE
θ value	6.88961 (rank : 1208)	NC score	0.015623 (rank : 1169)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1324	Shared Neighborhood Hits	140
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

MACF4_HUMAN
θ value	6.88961 (rank : 1209)	NC score	0.009406 (rank : 1240)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1321	Shared Neighborhood Hits	133
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MAGE1_HUMAN
θ value	6.88961 (rank : 1210)	NC score	0.023195 (rank : 1097)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1389	Shared Neighborhood Hits	238
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAP1A_HUMAN
θ value	6.88961 (rank : 1211)	NC score	0.040476 (rank : 1022)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1626	Shared Neighborhood Hits	261
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NCTR2_HUMAN
θ value	6.88961 (rank : 1212)	NC score	0.003907 (rank : 1311)
Query Neighborhood Hits	1275	Target Neighborhood Hits	99	Shared Neighborhood Hits	19
SwissProt Accessions	O95944, Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2	Gene names	NCR2, LY95
Domain Architecture
Description	Natural cytotoxicity triggering receptor 2 precursor (Natural killer cell p44-related protein) (NKp44) (NK-p44) (NK cell-activating receptor) (Lymphocyte antigen 95 homolog) (CD336 antigen).

NFAT5_MOUSE
θ value	6.88961 (rank : 1213)	NC score	0.001840 (rank : 1340)
Query Neighborhood Hits	1275	Target Neighborhood Hits	162	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WV30	Gene names	Nfat5
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T cell transcription factor NFAT5) (NF-AT5) (Rel domain-containing transcription factor NFAT5).

NUMBL_MOUSE
θ value	6.88961 (rank : 1214)	NC score	0.002623 (rank : 1323)
Query Neighborhood Hits	1275	Target Neighborhood Hits	147	Shared Neighborhood Hits	36
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

P66B_HUMAN
θ value	6.88961 (rank : 1215)	NC score	0.004201 (rank : 1307)
Query Neighborhood Hits	1275	Target Neighborhood Hits	61	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WXI9, Q7LG68, Q9ULS0	Gene names	GATAD2B, KIAA1150
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 beta (p66/p68) (GATA zinc finger domain- containing protein 2B).

PAX3_HUMAN
θ value	6.88961 (rank : 1216)	NC score	-0.012425 (rank : 1406)
Query Neighborhood Hits	1275	Target Neighborhood Hits	513	Shared Neighborhood Hits	50
SwissProt Accessions	P23760, Q16448	Gene names	PAX3, HUP2
Domain Architecture
Description	Paired box protein Pax-3 (HUP2).

PAX6_HUMAN
θ value	6.88961 (rank : 1217)	NC score	-0.013434 (rank : 1408)
Query Neighborhood Hits	1275	Target Neighborhood Hits	383	Shared Neighborhood Hits	19
SwissProt Accessions	P26367, Q6N006, Q99413	Gene names	PAX6, AN2
Domain Architecture
Description	Paired box protein Pax-6 (Oculorhombin) (Aniridia type II protein).

PAX6_MOUSE
θ value	6.88961 (rank : 1218)	NC score	-0.013434 (rank : 1409)
Query Neighborhood Hits	1275	Target Neighborhood Hits	383	Shared Neighborhood Hits	19
SwissProt Accessions	P63015, P32117, P70601, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8	Gene names	Pax6, Pax-6, Sey
Domain Architecture	No domain graphic available
Description	Paired box protein Pax-6 (Oculorhombin).

PGCA_HUMAN
θ value	6.88961 (rank : 1219)	NC score	-0.002567 (rank : 1376)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	102
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

PHC1_MOUSE
θ value	6.88961 (rank : 1220)	NC score	0.014966 (rank : 1177)
Query Neighborhood Hits	1275	Target Neighborhood Hits	205	Shared Neighborhood Hits	66
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

PINK1_MOUSE
θ value	6.88961 (rank : 1221)	NC score	0.731248 (rank : 718)
Query Neighborhood Hits	1275	Target Neighborhood Hits	726	Shared Neighborhood Hits	712
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PK1IP_MOUSE
θ value	6.88961 (rank : 1222)	NC score	-0.012292 (rank : 1404)
Query Neighborhood Hits	1275	Target Neighborhood Hits	313	Shared Neighborhood Hits	11
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

PPR3A_MOUSE
θ value	6.88961 (rank : 1223)	NC score	0.005655 (rank : 1281)
Query Neighborhood Hits	1275	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	Q99MR9, Q8BUJ4, Q8BUL0	Gene names	Ppp1r3a, Pp1g
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RGL).

PRR8_HUMAN
θ value	6.88961 (rank : 1224)	NC score	0.022568 (rank : 1103)
Query Neighborhood Hits	1275	Target Neighborhood Hits	217	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

RBP2_MOUSE
θ value	6.88961 (rank : 1225)	NC score	-0.005204 (rank : 1393)
Query Neighborhood Hits	1275	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

SCYBG_HUMAN
θ value	6.88961 (rank : 1226)	NC score	0.005032 (rank : 1293)
Query Neighborhood Hits	1275	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H2A7, Q8TC80, Q96K63, Q9BXD6, Q9H2F6	Gene names	CXCL16, SCYB16, SRPSOX
Domain Architecture	No domain graphic available
Description	Small inducible cytokine B16 precursor (Transmembrane chemokine CXCL16) (SR-PSOX) (Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein).

SFR15_HUMAN
θ value	6.88961 (rank : 1227)	NC score	0.027930 (rank : 1068)
Query Neighborhood Hits	1275	Target Neighborhood Hits	368	Shared Neighborhood Hits	114
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SI1L3_HUMAN
θ value	6.88961 (rank : 1228)	NC score	0.005202 (rank : 1289)
Query Neighborhood Hits	1275	Target Neighborhood Hits	305	Shared Neighborhood Hits	67
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SLIK4_HUMAN
θ value	6.88961 (rank : 1229)	NC score	-0.009320 (rank : 1402)
Query Neighborhood Hits	1275	Target Neighborhood Hits	287	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IW52, Q8TCM8, Q96DL3	Gene names	SLITRK4
Domain Architecture
Description	SLIT and NTRK-like protein 4 precursor.

SPR1A_MOUSE
θ value	6.88961 (rank : 1230)	NC score	0.009263 (rank : 1242)
Query Neighborhood Hits	1275	Target Neighborhood Hits	343	Shared Neighborhood Hits	65
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

TCOF_MOUSE
θ value	6.88961 (rank : 1231)	NC score	0.044115 (rank : 1010)
Query Neighborhood Hits	1275	Target Neighborhood Hits	471	Shared Neighborhood Hits	130
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

TTC28_HUMAN
θ value	6.88961 (rank : 1232)	NC score	0.006972 (rank : 1266)
Query Neighborhood Hits	1275	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

TULP4_HUMAN
θ value	6.88961 (rank : 1233)	NC score	0.008386 (rank : 1250)
Query Neighborhood Hits	1275	Target Neighborhood Hits	426	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

UTX_HUMAN
θ value	6.88961 (rank : 1234)	NC score	0.002292 (rank : 1332)
Query Neighborhood Hits	1275	Target Neighborhood Hits	161	Shared Neighborhood Hits	25
SwissProt Accessions	O15550	Gene names	UTX
Domain Architecture
Description	Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).

WHRN_MOUSE
θ value	6.88961 (rank : 1235)	NC score	0.004662 (rank : 1302)
Query Neighborhood Hits	1275	Target Neighborhood Hits	412	Shared Neighborhood Hits	71
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

YETS2_HUMAN
θ value	6.88961 (rank : 1236)	NC score	0.008464 (rank : 1248)
Query Neighborhood Hits	1275	Target Neighborhood Hits	212	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ULM3, Q641P6, Q9NW96	Gene names	YEATS2, KIAA1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ZC11A_HUMAN
θ value	6.88961 (rank : 1237)	NC score	0.014878 (rank : 1181)
Query Neighborhood Hits	1275	Target Neighborhood Hits	170	Shared Neighborhood Hits	36
SwissProt Accessions	O75152, Q6AHY4, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7	Gene names	ZC3H11A, KIAA0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

ANLN_MOUSE
θ value	8.99809 (rank : 1238)	NC score	0.014342 (rank : 1190)
Query Neighborhood Hits	1275	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

ANR15_HUMAN
θ value	8.99809 (rank : 1239)	NC score	0.006778 (rank : 1267)
Query Neighborhood Hits	1275	Target Neighborhood Hits	478	Shared Neighborhood Hits	57
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ANR26_HUMAN
θ value	8.99809 (rank : 1240)	NC score	0.015810 (rank : 1166)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1614	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

APC_HUMAN
θ value	8.99809 (rank : 1241)	NC score	0.017690 (rank : 1145)
Query Neighborhood Hits	1275	Target Neighborhood Hits	603	Shared Neighborhood Hits	133
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

BRD4_HUMAN
θ value	8.99809 (rank : 1242)	NC score	0.030638 (rank : 1056)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	239
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CECR2_HUMAN
θ value	8.99809 (rank : 1243)	NC score	0.001863 (rank : 1339)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CN145_MOUSE
θ value	8.99809 (rank : 1244)	NC score	0.014374 (rank : 1189)
Query Neighborhood Hits	1275	Target Neighborhood Hits	916	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

CNOT4_MOUSE
θ value	8.99809 (rank : 1245)	NC score	0.003402 (rank : 1314)
Query Neighborhood Hits	1275	Target Neighborhood Hits	277	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

DMP1_HUMAN
θ value	8.99809 (rank : 1246)	NC score	0.024542 (rank : 1083)
Query Neighborhood Hits	1275	Target Neighborhood Hits	491	Shared Neighborhood Hits	84
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

EDRF1_HUMAN
θ value	8.99809 (rank : 1247)	NC score	0.001040 (rank : 1350)
Query Neighborhood Hits	1275	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q3B7T1, Q4G190, Q8IZ74, Q9Y3W4	Gene names	EDRF1, C10orf137
Domain Architecture	No domain graphic available
Description	Erythroid differentiation-related factor 1.

ENAH_HUMAN
θ value	8.99809 (rank : 1248)	NC score	0.038964 (rank : 1026)
Query Neighborhood Hits	1275	Target Neighborhood Hits	784	Shared Neighborhood Hits	180
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

EPS8_MOUSE
θ value	8.99809 (rank : 1249)	NC score	0.018317 (rank : 1135)
Query Neighborhood Hits	1275	Target Neighborhood Hits	157	Shared Neighborhood Hits	37
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

FBXL6_HUMAN
θ value	8.99809 (rank : 1250)	NC score	-0.001701 (rank : 1372)
Query Neighborhood Hits	1275	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N531, Q9H5W9, Q9UKC7	Gene names	FBXL6, FBL6
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A).

H2AW_HUMAN
θ value	8.99809 (rank : 1251)	NC score	-0.005115 (rank : 1392)
Query Neighborhood Hits	1275	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P0M6, Q5SQT2	Gene names	H2AFY2, MACROH2A2
Domain Architecture
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

KCNH7_HUMAN
θ value	8.99809 (rank : 1252)	NC score	-0.004053 (rank : 1386)
Query Neighborhood Hits	1275	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

LAMP1_HUMAN
θ value	8.99809 (rank : 1253)	NC score	-0.000065 (rank : 1358)
Query Neighborhood Hits	1275	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	P11279	Gene names	LAMP1
Domain Architecture
Description	Lysosome-associated membrane glycoprotein 1 precursor (LAMP-1) (CD107a antigen).

MBB1A_MOUSE
θ value	8.99809 (rank : 1254)	NC score	0.012512 (rank : 1209)
Query Neighborhood Hits	1275	Target Neighborhood Hits	233	Shared Neighborhood Hits	56
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

MYPN_MOUSE
θ value	8.99809 (rank : 1255)	NC score	0.057013 (rank : 947)
Query Neighborhood Hits	1275	Target Neighborhood Hits	421	Shared Neighborhood Hits	92
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NKG2E_HUMAN
θ value	8.99809 (rank : 1256)	NC score	-0.004766 (rank : 1387)
Query Neighborhood Hits	1275	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q07444, Q96RL0, Q9UP04	Gene names	KLRC3, NKG2E
Domain Architecture
Description	NKG2-E type II integral membrane protein (NKG2-E-activating NK receptor) (NK cell receptor E).

NTKL_HUMAN
θ value	8.99809 (rank : 1257)	NC score	0.292281 (rank : 844)
Query Neighborhood Hits	1275	Target Neighborhood Hits	266	Shared Neighborhood Hits	229
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

P66B_MOUSE
θ value	8.99809 (rank : 1258)	NC score	0.004011 (rank : 1310)
Query Neighborhood Hits	1275	Target Neighborhood Hits	64	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VHR5, Q8C9Q3	Gene names	Gatad2b
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 beta (p66/p68) (GATA zinc finger domain- containing protein 2B).

PC11Y_HUMAN
θ value	8.99809 (rank : 1259)	NC score	-0.010921 (rank : 1403)
Query Neighborhood Hits	1275	Target Neighborhood Hits	205	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZA8, Q70LR6, Q70LR8, Q70LS0, Q70LS1, Q70LS2, Q70LS3, Q70LS4, Q70LS5, Q8WY34, Q9BZA9, Q9H4E1	Gene names	PCDH11Y, PCDH11, PCDH22, PCDHY
Domain Architecture	No domain graphic available
Description	Protocadherin-11 Y-linked precursor (Protocadherin-11) (Protocadherin- 22) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC).

PDLI1_MOUSE
θ value	8.99809 (rank : 1260)	NC score	0.003630 (rank : 1313)
Query Neighborhood Hits	1275	Target Neighborhood Hits	213	Shared Neighborhood Hits	20
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

PHLB2_MOUSE
θ value	8.99809 (rank : 1261)	NC score	0.024282 (rank : 1086)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1016	Shared Neighborhood Hits	126
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

REPS2_HUMAN
θ value	8.99809 (rank : 1262)	NC score	0.011215 (rank : 1224)
Query Neighborhood Hits	1275	Target Neighborhood Hits	131	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

SCG3_HUMAN
θ value	8.99809 (rank : 1263)	NC score	0.009021 (rank : 1243)
Query Neighborhood Hits	1275	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WXD2, Q96C83, Q96GE8, Q9Y6G7	Gene names	SCG3
Domain Architecture	No domain graphic available
Description	Secretogranin-3 precursor (Secretogranin III) (SgIII).

SEM6D_HUMAN
θ value	8.99809 (rank : 1264)	NC score	-0.005083 (rank : 1391)
Query Neighborhood Hits	1275	Target Neighborhood Hits	169	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

SGIP1_HUMAN
θ value	8.99809 (rank : 1265)	NC score	0.017867 (rank : 1143)
Query Neighborhood Hits	1275	Target Neighborhood Hits	198	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SRRM1_HUMAN
θ value	8.99809 (rank : 1266)	NC score	0.073835 (rank : 884)
Query Neighborhood Hits	1275	Target Neighborhood Hits	690	Shared Neighborhood Hits	207
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

STX18_HUMAN
θ value	8.99809 (rank : 1267)	NC score	0.002641 (rank : 1322)
Query Neighborhood Hits	1275	Target Neighborhood Hits	225	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P2W9, Q596L3, Q5TZP5	Gene names	STX18, GIG9
Domain Architecture	No domain graphic available
Description	Syntaxin-18 (Growth-inhibiting gene 9 protein).

TAF6_MOUSE
θ value	8.99809 (rank : 1268)	NC score	0.012112 (rank : 1216)
Query Neighborhood Hits	1275	Target Neighborhood Hits	110	Shared Neighborhood Hits	49
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

TEX14_HUMAN
θ value	8.99809 (rank : 1269)	NC score	0.489838 (rank : 831)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1103	Shared Neighborhood Hits	624
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TSH2_HUMAN
θ value	8.99809 (rank : 1270)	NC score	-0.006255 (rank : 1396)
Query Neighborhood Hits	1275	Target Neighborhood Hits	479	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NRE2, Q4VXM4, Q6N003, Q8N260	Gene names	TSHZ2, C20orf17, TSH2, ZNF218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (Ovarian cancer-related protein 10-2) (OVC10-2).

TTLL7_HUMAN
θ value	8.99809 (rank : 1271)	NC score	0.002578 (rank : 1324)
Query Neighborhood Hits	1275	Target Neighborhood Hits	95	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

TXLNB_MOUSE
θ value	8.99809 (rank : 1272)	NC score	0.021152 (rank : 1112)
Query Neighborhood Hits	1275	Target Neighborhood Hits	640	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

UACA_MOUSE
θ value	8.99809 (rank : 1273)	NC score	0.015468 (rank : 1170)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1620	Shared Neighborhood Hits	145
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

UBIP1_MOUSE
θ value	8.99809 (rank : 1274)	NC score	-0.000436 (rank : 1365)
Query Neighborhood Hits	1275	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q811S7, Q3UPR3, Q3US11, Q60786, Q8C514	Gene names	Ubp1, Cp2b, Nf2d9
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (Nuclear factor 2d9) (NF2d9).

YAP1_MOUSE
θ value	8.99809 (rank : 1275)	NC score	-0.000337 (rank : 1364)
Query Neighborhood Hits	1275	Target Neighborhood Hits	96	Shared Neighborhood Hits	24
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ANPRB_HUMAN
θ value	θ > 10 (rank : 1276)	NC score	0.537120 (rank : 824)
Query Neighborhood Hits	1275	Target Neighborhood Hits	646	Shared Neighborhood Hits	575
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 1277)	NC score	0.509351 (rank : 830)
Query Neighborhood Hits	1275	Target Neighborhood Hits	607	Shared Neighborhood Hits	552
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

APS_HUMAN
θ value	θ > 10 (rank : 1278)	NC score	0.057404 (rank : 944)
Query Neighborhood Hits	1275	Target Neighborhood Hits	162	Shared Neighborhood Hits	57
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

BOC_HUMAN
θ value	θ > 10 (rank : 1279)	NC score	0.050810 (rank : 989)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BUB1B_HUMAN
θ value	θ > 10 (rank : 1280)	NC score	0.096357 (rank : 867)
Query Neighborhood Hits	1275	Target Neighborhood Hits	208	Shared Neighborhood Hits	119
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1B_MOUSE
θ value	θ > 10 (rank : 1281)	NC score	0.089359 (rank : 868)
Query Neighborhood Hits	1275	Target Neighborhood Hits	202	Shared Neighborhood Hits	120
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

BUB1_MOUSE
θ value	θ > 10 (rank : 1282)	NC score	0.555306 (rank : 818)
Query Neighborhood Hits	1275	Target Neighborhood Hits	583	Shared Neighborhood Hits	538
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CHIN_HUMAN
θ value	θ > 10 (rank : 1283)	NC score	0.067008 (rank : 899)
Query Neighborhood Hits	1275	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1284)	NC score	0.068012 (rank : 897)
Query Neighborhood Hits	1275	Target Neighborhood Hits	229	Shared Neighborhood Hits	68
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1285)	NC score	0.067928 (rank : 898)
Query Neighborhood Hits	1275	Target Neighborhood Hits	220	Shared Neighborhood Hits	66
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 1286)	NC score	0.053643 (rank : 970)
Query Neighborhood Hits	1275	Target Neighborhood Hits	130	Shared Neighborhood Hits	40
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CNTN5_HUMAN
θ value	θ > 10 (rank : 1287)	NC score	0.052795 (rank : 976)
Query Neighborhood Hits	1275	Target Neighborhood Hits	446	Shared Neighborhood Hits	88
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CRKL_HUMAN
θ value	θ > 10 (rank : 1288)	NC score	0.070348 (rank : 894)
Query Neighborhood Hits	1275	Target Neighborhood Hits	313	Shared Neighborhood Hits	64
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 1289)	NC score	0.071296 (rank : 889)
Query Neighborhood Hits	1275	Target Neighborhood Hits	307	Shared Neighborhood Hits	63
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 1290)	NC score	0.059882 (rank : 926)
Query Neighborhood Hits	1275	Target Neighborhood Hits	308	Shared Neighborhood Hits	64
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 1291)	NC score	0.058798 (rank : 935)
Query Neighborhood Hits	1275	Target Neighborhood Hits	314	Shared Neighborhood Hits	66
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	θ > 10 (rank : 1292)	NC score	0.072684 (rank : 888)
Query Neighborhood Hits	1275	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 1293)	NC score	0.070559 (rank : 893)
Query Neighborhood Hits	1275	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCC_HUMAN
θ value	θ > 10 (rank : 1294)	NC score	0.065652 (rank : 904)
Query Neighborhood Hits	1275	Target Neighborhood Hits	583	Shared Neighborhood Hits	117
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DGKD_HUMAN
θ value	θ > 10 (rank : 1295)	NC score	0.066386 (rank : 900)
Query Neighborhood Hits	1275	Target Neighborhood Hits	231	Shared Neighborhood Hits	76
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1296)	NC score	0.060175 (rank : 924)
Query Neighborhood Hits	1275	Target Neighborhood Hits	255	Shared Neighborhood Hits	69
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1297)	NC score	0.054481 (rank : 962)
Query Neighborhood Hits	1275	Target Neighborhood Hits	131	Shared Neighborhood Hits	38
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

DSCAM_HUMAN
θ value	θ > 10 (rank : 1298)	NC score	0.059418 (rank : 931)
Query Neighborhood Hits	1275	Target Neighborhood Hits	524	Shared Neighborhood Hits	97
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
θ value	θ > 10 (rank : 1299)	NC score	0.062644 (rank : 915)
Query Neighborhood Hits	1275	Target Neighborhood Hits	589	Shared Neighborhood Hits	127
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 1300)	NC score	0.050176 (rank : 996)
Query Neighborhood Hits	1275	Target Neighborhood Hits	206	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FGRL1_HUMAN
θ value	θ > 10 (rank : 1301)	NC score	0.063049 (rank : 912)
Query Neighborhood Hits	1275	Target Neighborhood Hits	335	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

FGRL1_MOUSE
θ value	θ > 10 (rank : 1302)	NC score	0.064994 (rank : 907)
Query Neighborhood Hits	1275	Target Neighborhood Hits	325	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

GRAP2_HUMAN
θ value	θ > 10 (rank : 1303)	NC score	0.102165 (rank : 862)
Query Neighborhood Hits	1275	Target Neighborhood Hits	304	Shared Neighborhood Hits	65
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1304)	NC score	0.100391 (rank : 863)
Query Neighborhood Hits	1275	Target Neighborhood Hits	297	Shared Neighborhood Hits	62
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1305)	NC score	0.105863 (rank : 858)
Query Neighborhood Hits	1275	Target Neighborhood Hits	307	Shared Neighborhood Hits	68
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1306)	NC score	0.105289 (rank : 859)
Query Neighborhood Hits	1275	Target Neighborhood Hits	309	Shared Neighborhood Hits	66
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB14_HUMAN
θ value	θ > 10 (rank : 1307)	NC score	0.057981 (rank : 940)
Query Neighborhood Hits	1275	Target Neighborhood Hits	137	Shared Neighborhood Hits	42
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 1308)	NC score	0.063017 (rank : 913)
Query Neighborhood Hits	1275	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 1309)	NC score	0.102625 (rank : 860)
Query Neighborhood Hits	1275	Target Neighborhood Hits	310	Shared Neighborhood Hits	65
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1310)	NC score	0.102574 (rank : 861)
Query Neighborhood Hits	1275	Target Neighborhood Hits	312	Shared Neighborhood Hits	65
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB7_MOUSE
θ value	θ > 10 (rank : 1311)	NC score	0.054469 (rank : 963)
Query Neighborhood Hits	1275	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRP3_HUMAN
θ value	θ > 10 (rank : 1312)	NC score	0.080414 (rank : 880)
Query Neighborhood Hits	1275	Target Neighborhood Hits	131	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GUC2C_HUMAN
θ value	θ > 10 (rank : 1313)	NC score	0.544264 (rank : 820)
Query Neighborhood Hits	1275	Target Neighborhood Hits	624	Shared Neighborhood Hits	577
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

HSH2D_HUMAN
θ value	θ > 10 (rank : 1314)	NC score	0.068203 (rank : 896)
Query Neighborhood Hits	1275	Target Neighborhood Hits	159	Shared Neighborhood Hits	47
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ILK1_HUMAN
θ value	θ > 10 (rank : 1315)	NC score	0.457806 (rank : 834)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	592
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 1316)	NC score	0.443407 (rank : 836)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	583
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 1317)	NC score	0.456775 (rank : 835)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	593
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

K2002_HUMAN
θ value	θ > 10 (rank : 1318)	NC score	0.285973 (rank : 847)
Query Neighborhood Hits	1275	Target Neighborhood Hits	274	Shared Neighborhood Hits	260
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

K2002_MOUSE
θ value	θ > 10 (rank : 1319)	NC score	0.234950 (rank : 848)
Query Neighborhood Hits	1275	Target Neighborhood Hits	267	Shared Neighborhood Hits	230
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

L1CAM_HUMAN
θ value	θ > 10 (rank : 1320)	NC score	0.058885 (rank : 932)
Query Neighborhood Hits	1275	Target Neighborhood Hits	457	Shared Neighborhood Hits	96
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_MOUSE
θ value	θ > 10 (rank : 1321)	NC score	0.055670 (rank : 955)
Query Neighborhood Hits	1275	Target Neighborhood Hits	457	Shared Neighborhood Hits	95
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

LNK_HUMAN
θ value	θ > 10 (rank : 1322)	NC score	0.053277 (rank : 971)
Query Neighborhood Hits	1275	Target Neighborhood Hits	151	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

MLKL_HUMAN
θ value	θ > 10 (rank : 1323)	NC score	0.619760 (rank : 811)
Query Neighborhood Hits	1275	Target Neighborhood Hits	600	Shared Neighborhood Hits	570
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MUC7_HUMAN
θ value	θ > 10 (rank : 1324)	NC score	0.052359 (rank : 981)
Query Neighborhood Hits	1275	Target Neighborhood Hits	538	Shared Neighborhood Hits	180
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MYOM1_HUMAN
θ value	θ > 10 (rank : 1325)	NC score	0.066067 (rank : 901)
Query Neighborhood Hits	1275	Target Neighborhood Hits	405	Shared Neighborhood Hits	103
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM1_MOUSE
θ value	θ > 10 (rank : 1326)	NC score	0.064300 (rank : 909)
Query Neighborhood Hits	1275	Target Neighborhood Hits	415	Shared Neighborhood Hits	102
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MYOM2_HUMAN
θ value	θ > 10 (rank : 1327)	NC score	0.059737 (rank : 928)
Query Neighborhood Hits	1275	Target Neighborhood Hits	341	Shared Neighborhood Hits	76
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYOTI_HUMAN
θ value	θ > 10 (rank : 1328)	NC score	0.052747 (rank : 977)
Query Neighborhood Hits	1275	Target Neighborhood Hits	292	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
θ value	θ > 10 (rank : 1329)	NC score	0.050204 (rank : 995)
Query Neighborhood Hits	1275	Target Neighborhood Hits	297	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYPC3_HUMAN
θ value	θ > 10 (rank : 1330)	NC score	0.054568 (rank : 960)
Query Neighborhood Hits	1275	Target Neighborhood Hits	318	Shared Neighborhood Hits	73
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC3_MOUSE
θ value	θ > 10 (rank : 1331)	NC score	0.057590 (rank : 942)
Query Neighborhood Hits	1275	Target Neighborhood Hits	310	Shared Neighborhood Hits	71
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPN_HUMAN
θ value	θ > 10 (rank : 1332)	NC score	0.055934 (rank : 954)
Query Neighborhood Hits	1275	Target Neighborhood Hits	418	Shared Neighborhood Hits	90
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

NCA11_HUMAN
θ value	θ > 10 (rank : 1333)	NC score	0.052619 (rank : 978)
Query Neighborhood Hits	1275	Target Neighborhood Hits	443	Shared Neighborhood Hits	76
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA11_MOUSE
θ value	θ > 10 (rank : 1334)	NC score	0.056004 (rank : 952)
Query Neighborhood Hits	1275	Target Neighborhood Hits	661	Shared Neighborhood Hits	154
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NCA12_HUMAN
θ value	θ > 10 (rank : 1335)	NC score	0.052101 (rank : 983)
Query Neighborhood Hits	1275	Target Neighborhood Hits	437	Shared Neighborhood Hits	75
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCAM2_HUMAN
θ value	θ > 10 (rank : 1336)	NC score	0.057714 (rank : 941)
Query Neighborhood Hits	1275	Target Neighborhood Hits	441	Shared Neighborhood Hits	84
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NCAM2_MOUSE
θ value	θ > 10 (rank : 1337)	NC score	0.059670 (rank : 930)
Query Neighborhood Hits	1275	Target Neighborhood Hits	472	Shared Neighborhood Hits	87
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCK1_HUMAN
θ value	θ > 10 (rank : 1338)	NC score	0.098179 (rank : 865)
Query Neighborhood Hits	1275	Target Neighborhood Hits	312	Shared Neighborhood Hits	66
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 1339)	NC score	0.098211 (rank : 864)
Query Neighborhood Hits	1275	Target Neighborhood Hits	310	Shared Neighborhood Hits	68
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEO1_HUMAN
θ value	θ > 10 (rank : 1340)	NC score	0.070764 (rank : 891)
Query Neighborhood Hits	1275	Target Neighborhood Hits	530	Shared Neighborhood Hits	106
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	θ > 10 (rank : 1341)	NC score	0.070745 (rank : 892)
Query Neighborhood Hits	1275	Target Neighborhood Hits	523	Shared Neighborhood Hits	107
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NFASC_HUMAN
θ value	θ > 10 (rank : 1342)	NC score	0.057378 (rank : 945)
Query Neighborhood Hits	1275	Target Neighborhood Hits	497	Shared Neighborhood Hits	109
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NFASC_MOUSE
θ value	θ > 10 (rank : 1343)	NC score	0.052211 (rank : 982)
Query Neighborhood Hits	1275	Target Neighborhood Hits	475	Shared Neighborhood Hits	101
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

NPHP1_HUMAN
θ value	θ > 10 (rank : 1344)	NC score	0.054120 (rank : 967)
Query Neighborhood Hits	1275	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 1345)	NC score	0.055409 (rank : 957)
Query Neighborhood Hits	1275	Target Neighborhood Hits	267	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NRBP_HUMAN
θ value	θ > 10 (rank : 1346)	NC score	0.488899 (rank : 832)
Query Neighborhood Hits	1275	Target Neighborhood Hits	448	Shared Neighborhood Hits	420
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
θ value	θ > 10 (rank : 1347)	NC score	0.486736 (rank : 833)
Query Neighborhood Hits	1275	Target Neighborhood Hits	442	Shared Neighborhood Hits	416
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

NRCAM_HUMAN
θ value	θ > 10 (rank : 1348)	NC score	0.056898 (rank : 948)
Query Neighborhood Hits	1275	Target Neighborhood Hits	439	Shared Neighborhood Hits	90
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NRCAM_MOUSE
θ value	θ > 10 (rank : 1349)	NC score	0.054957 (rank : 959)
Query Neighborhood Hits	1275	Target Neighborhood Hits	432	Shared Neighborhood Hits	89
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

P55G_HUMAN
θ value	θ > 10 (rank : 1350)	NC score	0.062480 (rank : 918)
Query Neighborhood Hits	1275	Target Neighborhood Hits	451	Shared Neighborhood Hits	81
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 1351)	NC score	0.063581 (rank : 911)
Query Neighborhood Hits	1275	Target Neighborhood Hits	401	Shared Neighborhood Hits	84
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 1352)	NC score	0.052846 (rank : 974)
Query Neighborhood Hits	1275	Target Neighborhood Hits	479	Shared Neighborhood Hits	85
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 1353)	NC score	0.051891 (rank : 984)
Query Neighborhood Hits	1275	Target Neighborhood Hits	435	Shared Neighborhood Hits	84
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 1354)	NC score	0.064061 (rank : 910)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	102
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 1355)	NC score	0.065931 (rank : 902)
Query Neighborhood Hits	1275	Target Neighborhood Hits	519	Shared Neighborhood Hits	92
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACE1_HUMAN
θ value	θ > 10 (rank : 1356)	NC score	0.059730 (rank : 929)
Query Neighborhood Hits	1275	Target Neighborhood Hits	74	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PACE1_MOUSE
θ value	θ > 10 (rank : 1357)	NC score	0.060963 (rank : 922)
Query Neighborhood Hits	1275	Target Neighborhood Hits	92	Shared Neighborhood Hits	58
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PDZD8_HUMAN
θ value	θ > 10 (rank : 1358)	NC score	0.065919 (rank : 903)
Query Neighborhood Hits	1275	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PGFRL_HUMAN
θ value	θ > 10 (rank : 1359)	NC score	0.058531 (rank : 937)
Query Neighborhood Hits	1275	Target Neighborhood Hits	115	Shared Neighborhood Hits	31
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PGFRL_MOUSE
θ value	θ > 10 (rank : 1360)	NC score	0.058881 (rank : 933)
Query Neighborhood Hits	1275	Target Neighborhood Hits	106	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PLCG1_HUMAN
θ value	θ > 10 (rank : 1361)	NC score	0.062525 (rank : 916)
Query Neighborhood Hits	1275	Target Neighborhood Hits	293	Shared Neighborhood Hits	68
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 1362)	NC score	0.062812 (rank : 914)
Query Neighborhood Hits	1275	Target Neighborhood Hits	314	Shared Neighborhood Hits	70
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 1363)	NC score	0.061308 (rank : 921)
Query Neighborhood Hits	1275	Target Neighborhood Hits	280	Shared Neighborhood Hits	60
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PRB4S_HUMAN
θ value	θ > 10 (rank : 1364)	NC score	0.052490 (rank : 980)
Query Neighborhood Hits	1275	Target Neighborhood Hits	330	Shared Neighborhood Hits	118
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRPK_HUMAN
θ value	θ > 10 (rank : 1365)	NC score	0.141384 (rank : 854)
Query Neighborhood Hits	1275	Target Neighborhood Hits	131	Shared Neighborhood Hits	129
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 1366)	NC score	0.153302 (rank : 850)
Query Neighborhood Hits	1275	Target Neighborhood Hits	139	Shared Neighborhood Hits	133
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PTPRD_HUMAN
θ value	θ > 10 (rank : 1367)	NC score	0.050299 (rank : 992)
Query Neighborhood Hits	1275	Target Neighborhood Hits	485	Shared Neighborhood Hits	93
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PUNC_HUMAN
θ value	θ > 10 (rank : 1368)	NC score	0.050119 (rank : 997)
Query Neighborhood Hits	1275	Target Neighborhood Hits	449	Shared Neighborhood Hits	74
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

RASA1_HUMAN
θ value	θ > 10 (rank : 1369)	NC score	0.082538 (rank : 875)
Query Neighborhood Hits	1275	Target Neighborhood Hits	258	Shared Neighborhood Hits	66
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_HUMAN
θ value	θ > 10 (rank : 1370)	NC score	0.051098 (rank : 988)
Query Neighborhood Hits	1275	Target Neighborhood Hits	62	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 1371)	NC score	0.062485 (rank : 917)
Query Neighborhood Hits	1275	Target Neighborhood Hits	74	Shared Neighborhood Hits	34
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RN5A_HUMAN
θ value	θ > 10 (rank : 1372)	NC score	0.151331 (rank : 851)
Query Neighborhood Hits	1275	Target Neighborhood Hits	608	Shared Neighborhood Hits	336
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ROBO1_HUMAN
θ value	θ > 10 (rank : 1373)	NC score	0.057444 (rank : 943)
Query Neighborhood Hits	1275	Target Neighborhood Hits	529	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO1_MOUSE
θ value	θ > 10 (rank : 1374)	NC score	0.058335 (rank : 938)
Query Neighborhood Hits	1275	Target Neighborhood Hits	559	Shared Neighborhood Hits	121
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO2_HUMAN
θ value	θ > 10 (rank : 1375)	NC score	0.055997 (rank : 953)
Query Neighborhood Hits	1275	Target Neighborhood Hits	479	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
θ value	θ > 10 (rank : 1376)	NC score	0.056207 (rank : 951)
Query Neighborhood Hits	1275	Target Neighborhood Hits	504	Shared Neighborhood Hits	91
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_HUMAN
θ value	θ > 10 (rank : 1377)	NC score	0.056593 (rank : 949)
Query Neighborhood Hits	1275	Target Neighborhood Hits	570	Shared Neighborhood Hits	121
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

ROBO3_MOUSE
θ value	θ > 10 (rank : 1378)	NC score	0.053129 (rank : 972)
Query Neighborhood Hits	1275	Target Neighborhood Hits	524	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

SCYL2_HUMAN
θ value	θ > 10 (rank : 1379)	NC score	0.588896 (rank : 815)
Query Neighborhood Hits	1275	Target Neighborhood Hits	632	Shared Neighborhood Hits	562
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 1380)	NC score	0.568229 (rank : 816)
Query Neighborhood Hits	1275	Target Neighborhood Hits	603	Shared Neighborhood Hits	542
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SDK1_HUMAN
θ value	θ > 10 (rank : 1381)	NC score	0.061622 (rank : 920)
Query Neighborhood Hits	1275	Target Neighborhood Hits	511	Shared Neighborhood Hits	104
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_MOUSE
θ value	θ > 10 (rank : 1382)	NC score	0.059926 (rank : 925)
Query Neighborhood Hits	1275	Target Neighborhood Hits	495	Shared Neighborhood Hits	100
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
θ value	θ > 10 (rank : 1383)	NC score	0.059818 (rank : 927)
Query Neighborhood Hits	1275	Target Neighborhood Hits	495	Shared Neighborhood Hits	101
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
θ value	θ > 10 (rank : 1384)	NC score	0.058122 (rank : 939)
Query Neighborhood Hits	1275	Target Neighborhood Hits	480	Shared Neighborhood Hits	97
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SH21A_HUMAN
θ value	θ > 10 (rank : 1385)	NC score	0.081160 (rank : 877)
Query Neighborhood Hits	1275	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 1386)	NC score	0.087444 (rank : 873)
Query Neighborhood Hits	1275	Target Neighborhood Hits	89	Shared Neighborhood Hits	39
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1387)	NC score	0.087366 (rank : 874)
Query Neighborhood Hits	1275	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1388)	NC score	0.097893 (rank : 866)
Query Neighborhood Hits	1275	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH24A_HUMAN
θ value	θ > 10 (rank : 1389)	NC score	0.062295 (rank : 919)
Query Neighborhood Hits	1275	Target Neighborhood Hits	455	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SHB_HUMAN
θ value	θ > 10 (rank : 1390)	NC score	0.051693 (rank : 986)
Query Neighborhood Hits	1275	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 1391)	NC score	0.053845 (rank : 968)
Query Neighborhood Hits	1275	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 1392)	NC score	0.054487 (rank : 961)
Query Neighborhood Hits	1275	Target Neighborhood Hits	170	Shared Neighborhood Hits	56
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 1393)	NC score	0.053781 (rank : 969)
Query Neighborhood Hits	1275	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 1394)	NC score	0.054293 (rank : 964)
Query Neighborhood Hits	1275	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHD_HUMAN
θ value	θ > 10 (rank : 1395)	NC score	0.050222 (rank : 994)
Query Neighborhood Hits	1275	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 1396)	NC score	0.051294 (rank : 987)
Query Neighborhood Hits	1275	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 1397)	NC score	0.065335 (rank : 906)
Query Neighborhood Hits	1275	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 1398)	NC score	0.065487 (rank : 905)
Query Neighborhood Hits	1275	Target Neighborhood Hits	169	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 1399)	NC score	0.141053 (rank : 855)
Query Neighborhood Hits	1275	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 1400)	NC score	0.139045 (rank : 856)
Query Neighborhood Hits	1275	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 1401)	NC score	0.141402 (rank : 853)
Query Neighborhood Hits	1275	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 1402)	NC score	0.145462 (rank : 852)
Query Neighborhood Hits	1275	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPN90_HUMAN
θ value	θ > 10 (rank : 1403)	NC score	0.054262 (rank : 965)
Query Neighborhood Hits	1275	Target Neighborhood Hits	157	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 1404)	NC score	0.051716 (rank : 985)
Query Neighborhood Hits	1275	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

STAC3_HUMAN
θ value	θ > 10 (rank : 1405)	NC score	0.088298 (rank : 871)
Query Neighborhood Hits	1275	Target Neighborhood Hits	228	Shared Neighborhood Hits	73
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1406)	NC score	0.088634 (rank : 870)
Query Neighborhood Hits	1275	Target Neighborhood Hits	232	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1407)	NC score	0.082312 (rank : 876)
Query Neighborhood Hits	1275	Target Neighborhood Hits	276	Shared Neighborhood Hits	85
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1408)	NC score	0.088889 (rank : 869)
Query Neighborhood Hits	1275	Target Neighborhood Hits	268	Shared Neighborhood Hits	86
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STK31_MOUSE
θ value	θ > 10 (rank : 1409)	NC score	0.302237 (rank : 843)
Query Neighborhood Hits	1275	Target Neighborhood Hits	474	Shared Neighborhood Hits	323
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

TRIB2_HUMAN
θ value	θ > 10 (rank : 1410)	NC score	0.720606 (rank : 743)
Query Neighborhood Hits	1275	Target Neighborhood Hits	657	Shared Neighborhood Hits	646
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	θ > 10 (rank : 1411)	NC score	0.719740 (rank : 745)
Query Neighborhood Hits	1275	Target Neighborhood Hits	653	Shared Neighborhood Hits	642
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

UN13A_HUMAN
θ value	θ > 10 (rank : 1412)	NC score	0.060332 (rank : 923)
Query Neighborhood Hits	1275	Target Neighborhood Hits	285	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 1413)	NC score	0.057283 (rank : 946)
Query Neighborhood Hits	1275	Target Neighborhood Hits	217	Shared Neighborhood Hits	47
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 1414)	NC score	0.055257 (rank : 958)
Query Neighborhood Hits	1275	Target Neighborhood Hits	210	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 1415)	NC score	0.075886 (rank : 883)
Query Neighborhood Hits	1275	Target Neighborhood Hits	453	Shared Neighborhood Hits	100
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1416)	NC score	0.072830 (rank : 886)
Query Neighborhood Hits	1275	Target Neighborhood Hits	456	Shared Neighborhood Hits	98
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1417)	NC score	0.080864 (rank : 878)
Query Neighborhood Hits	1275	Target Neighborhood Hits	398	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 1418)	NC score	0.080707 (rank : 879)
Query Neighborhood Hits	1275	Target Neighborhood Hits	404	Shared Neighborhood Hits	102
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1419)	NC score	0.078330 (rank : 881)
Query Neighborhood Hits	1275	Target Neighborhood Hits	452	Shared Neighborhood Hits	100
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1420)	NC score	0.072829 (rank : 887)
Query Neighborhood Hits	1275	Target Neighborhood Hits	430	Shared Neighborhood Hits	98
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

CD2L7_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1275	Shared Neighborhood Hits	1275
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CD2L5_HUMAN
NC score	0.990471 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	1275	Target Neighborhood Hits	987	Shared Neighborhood Hits	864
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
NC score	0.990379 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1011	Shared Neighborhood Hits	878
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CDK9_MOUSE
NC score	0.979388 (rank : 4)	θ value	1.95861e-79 (rank : 4)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CDK9_HUMAN
NC score	0.979338 (rank : 5)	θ value	7.44272e-79 (rank : 5)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDC2_HUMAN
NC score	0.978834 (rank : 6)	θ value	1.19377e-60 (rank : 12)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	826
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK3_HUMAN
NC score	0.978673 (rank : 7)	θ value	2.56992e-63 (rank : 10)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDC2_MOUSE
NC score	0.978225 (rank : 8)	θ value	4.53632e-60 (rank : 14)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK2_HUMAN
NC score	0.978220 (rank : 9)	θ value	9.76566e-63 (rank : 11)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

CDK7_HUMAN
NC score	0.978003 (rank : 10)	θ value	1.56274e-52 (rank : 25)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	821
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
NC score	0.977928 (rank : 11)	θ value	7.75577e-52 (rank : 26)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	821
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK2_MOUSE
NC score	0.977898 (rank : 12)	θ value	1.97229e-55 (rank : 21)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	821
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CCRK_HUMAN
NC score	0.977628 (rank : 13)	θ value	4.53632e-60 (rank : 13)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	821
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CDK5_HUMAN
NC score	0.977613 (rank : 14)	θ value	4.24587e-58 (rank : 15)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	814
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
NC score	0.977591 (rank : 15)	θ value	7.24236e-58 (rank : 16)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	814
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CCRK_MOUSE
NC score	0.976752 (rank : 16)	θ value	1.23536e-57 (rank : 17)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	819
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CDK10_HUMAN
NC score	0.976460 (rank : 17)	θ value	1.11475e-66 (rank : 6)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	822
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

AL2S7_HUMAN
NC score	0.975115 (rank : 18)	θ value	5.7518e-47 (rank : 38)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	818
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

PFTK1_HUMAN
NC score	0.974765 (rank : 19)	θ value	2.94719e-51 (rank : 27)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	816
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_MOUSE
NC score	0.974756 (rank : 20)	θ value	6.56568e-51 (rank : 28)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	816
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

CDK6_MOUSE
NC score	0.974704 (rank : 21)	θ value	7.25919e-50 (rank : 31)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	824
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

PCTK3_MOUSE
NC score	0.974500 (rank : 22)	θ value	5.19021e-56 (rank : 20)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	818
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDK6_HUMAN
NC score	0.974417 (rank : 23)	θ value	9.48078e-50 (rank : 32)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	824
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

PCTK2_HUMAN
NC score	0.974403 (rank : 24)	θ value	1.36585e-56 (rank : 18)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	818
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK1_HUMAN
NC score	0.974261 (rank : 25)	θ value	1.97229e-55 (rank : 22)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	819
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK2_MOUSE
NC score	0.974235 (rank : 26)	θ value	1.78386e-56 (rank : 19)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	818
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK1_MOUSE
NC score	0.974154 (rank : 27)	θ value	5.73848e-55 (rank : 23)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	817
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK3_HUMAN
NC score	0.973291 (rank : 28)	θ value	7.49467e-55 (rank : 24)
Query Neighborhood Hits	1275	Target Neighborhood Hits	827	Shared Neighborhood Hits	812
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDKL4_MOUSE
NC score	0.973163 (rank : 29)	θ value	1.23823e-49 (rank : 33)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	820
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDK3_MOUSE
NC score	0.972922 (rank : 30)	θ value	8.59492e-43 (rank : 54)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	821
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

CDK4_MOUSE
NC score	0.972767 (rank : 31)	θ value	3.72821e-46 (rank : 39)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	823
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

CDKL2_HUMAN
NC score	0.972319 (rank : 32)	θ value	2.49495e-50 (rank : 30)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	822
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

ICK_MOUSE
NC score	0.972169 (rank : 33)	θ value	2.67181e-44 (rank : 48)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	827
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

ICK_HUMAN
NC score	0.972086 (rank : 34)	θ value	5.38352e-45 (rank : 44)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	828
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

CDK4_HUMAN
NC score	0.971863 (rank : 35)	θ value	1.85029e-45 (rank : 43)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	823
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDKL4_HUMAN
NC score	0.971848 (rank : 36)	θ value	3.72821e-46 (rank : 40)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	818
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

CDKL2_MOUSE
NC score	0.971593 (rank : 37)	θ value	8.87376e-48 (rank : 36)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	822
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

MAK_MOUSE
NC score	0.971534 (rank : 38)	θ value	5.95217e-44 (rank : 51)
Query Neighborhood Hits	1275	Target Neighborhood Hits	873	Shared Neighborhood Hits	837
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MAK_HUMAN
NC score	0.971151 (rank : 39)	θ value	5.95217e-44 (rank : 50)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	831
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

CDKL1_HUMAN
NC score	0.969937 (rank : 40)	θ value	2.75849e-49 (rank : 34)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	820
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

MK07_MOUSE
NC score	0.969654 (rank : 41)	θ value	2.50074e-42 (rank : 55)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1054	Shared Neighborhood Hits	911
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

CDKL5_HUMAN
NC score	0.969389 (rank : 42)	θ value	1.91031e-50 (rank : 29)
Query Neighborhood Hits	1275	Target Neighborhood Hits	967	Shared Neighborhood Hits	850
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

MK07_HUMAN
NC score	0.968778 (rank : 43)	θ value	2.95404e-43 (rank : 52)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1087	Shared Neighborhood Hits	919
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

CDKL3_HUMAN
NC score	0.968701 (rank : 44)	θ value	8.04462e-41 (rank : 59)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	832
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CDKL3_MOUSE
NC score	0.968242 (rank : 45)	θ value	7.27602e-42 (rank : 56)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	829
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CDKL1_MOUSE
NC score	0.968108 (rank : 46)	θ value	1.788e-48 (rank : 35)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	819
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

NLK_MOUSE
NC score	0.967883 (rank : 47)	θ value	5.21438e-40 (rank : 64)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	826
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NLK_HUMAN
NC score	0.967834 (rank : 48)	θ value	5.21438e-40 (rank : 63)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	826
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

MK03_HUMAN
NC score	0.966915 (rank : 49)	θ value	2.04573e-44 (rank : 47)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
NC score	0.966554 (rank : 50)	θ value	2.67181e-44 (rank : 49)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	824
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK12_MOUSE
NC score	0.966150 (rank : 51)	θ value	3.85808e-43 (rank : 53)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	820
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK12_HUMAN
NC score	0.965907 (rank : 52)	θ value	1.3722e-40 (rank : 61)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	820
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK01_HUMAN
NC score	0.965075 (rank : 53)	θ value	7.03111e-45 (rank : 45)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	820
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK15_HUMAN
NC score	0.965038 (rank : 54)	θ value	5.76516e-39 (rank : 68)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1038	Shared Neighborhood Hits	853
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

MK01_MOUSE
NC score	0.964999 (rank : 55)	θ value	9.18288e-45 (rank : 46)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	820
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK15_MOUSE
NC score	0.964757 (rank : 56)	θ value	5.21438e-40 (rank : 62)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	822
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MK13_MOUSE
NC score	0.964353 (rank : 57)	θ value	2.11701e-41 (rank : 57)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	819
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_HUMAN
NC score	0.964248 (rank : 58)	θ value	6.81017e-40 (rank : 65)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	819
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK14_MOUSE
NC score	0.964013 (rank : 59)	θ value	4.88048e-38 (rank : 69)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	823
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

MK14_HUMAN
NC score	0.963967 (rank : 60)	θ value	1.08726e-37 (rank : 70)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	823
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

CD2L2_HUMAN
NC score	0.963888 (rank : 61)	θ value	3.03575e-64 (rank : 7)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1439	Shared Neighborhood Hits	894
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

MK11_MOUSE
NC score	0.961649 (rank : 62)	θ value	4.568e-36 (rank : 71)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	825
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

CD2L6_MOUSE
NC score	0.961438 (rank : 63)	θ value	8.30557e-46 (rank : 42)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	817
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L6_HUMAN
NC score	0.961425 (rank : 64)	θ value	3.37202e-47 (rank : 37)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

MK11_HUMAN
NC score	0.961381 (rank : 65)	θ value	7.79185e-36 (rank : 72)
Query Neighborhood Hits	1275	Target Neighborhood Hits	823	Shared Neighborhood Hits	817
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

CD2L1_HUMAN
NC score	0.961054 (rank : 66)	θ value	3.96481e-64 (rank : 8)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1467	Shared Neighborhood Hits	890
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CDK8_HUMAN
NC score	0.960270 (rank : 67)	θ value	6.35935e-46 (rank : 41)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	814
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

CD2L1_MOUSE
NC score	0.959514 (rank : 68)	θ value	2.56992e-63 (rank : 9)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1463	Shared Neighborhood Hits	888
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

MK04_HUMAN
NC score	0.959173 (rank : 69)	θ value	8.04462e-41 (rank : 60)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK04_MOUSE
NC score	0.957668 (rank : 70)	θ value	2.76489e-41 (rank : 58)
Query Neighborhood Hits	1275	Target Neighborhood Hits	852	Shared Neighborhood Hits	807
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

GSK3A_HUMAN
NC score	0.954554 (rank : 71)	θ value	6.38894e-30 (rank : 77)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	798
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

MK06_HUMAN
NC score	0.953507 (rank : 72)	θ value	4.41421e-39 (rank : 67)
Query Neighborhood Hits	1275	Target Neighborhood Hits	815	Shared Neighborhood Hits	792
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
NC score	0.953349 (rank : 73)	θ value	1.98146e-39 (rank : 66)
Query Neighborhood Hits	1275	Target Neighborhood Hits	818	Shared Neighborhood Hits	793
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MOK_HUMAN
NC score	0.953016 (rank : 74)	θ value	8.91499e-32 (rank : 74)
Query Neighborhood Hits	1275	Target Neighborhood Hits	807	Shared Neighborhood Hits	796
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

GSK3B_HUMAN
NC score	0.952594 (rank : 75)	θ value	6.38894e-30 (rank : 78)
Query Neighborhood Hits	1275	Target Neighborhood Hits	801	Shared Neighborhood Hits	795
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.952592 (rank : 76)	θ value	6.38894e-30 (rank : 79)
Query Neighborhood Hits	1275	Target Neighborhood Hits	800	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

MOK_MOUSE
NC score	0.952580 (rank : 77)	θ value	4.00176e-32 (rank : 73)
Query Neighborhood Hits	1275	Target Neighborhood Hits	796	Shared Neighborhood Hits	788
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MK10_MOUSE
NC score	0.952433 (rank : 78)	θ value	2.59387e-31 (rank : 75)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	818
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_HUMAN
NC score	0.952334 (rank : 79)	θ value	7.54701e-31 (rank : 76)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	816
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK08_MOUSE
NC score	0.952195 (rank : 80)	θ value	1.85889e-29 (rank : 81)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	818
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK09_HUMAN
NC score	0.952143 (rank : 81)	θ value	5.40856e-29 (rank : 82)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK08_HUMAN
NC score	0.951604 (rank : 82)	θ value	1.4233e-29 (rank : 80)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	818
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK09_MOUSE
NC score	0.951559 (rank : 83)	θ value	1.33217e-27 (rank : 83)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	819
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

STK36_MOUSE
NC score	0.941190 (rank : 84)	θ value	4.28545e-26 (rank : 91)
Query Neighborhood Hits	1275	Target Neighborhood Hits	877	Shared Neighborhood Hits	830
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_HUMAN
NC score	0.936997 (rank : 85)	θ value	1.12775e-26 (rank : 87)
Query Neighborhood Hits	1275	Target Neighborhood Hits	896	Shared Neighborhood Hits	833
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

CSK21_MOUSE
NC score	0.931858 (rank : 86)	θ value	3.28125e-26 (rank : 90)
Query Neighborhood Hits	1275	Target Neighborhood Hits	770	Shared Neighborhood Hits	763
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_HUMAN
NC score	0.931851 (rank : 87)	θ value	5.59698e-26 (rank : 92)
Query Neighborhood Hits	1275	Target Neighborhood Hits	772	Shared Neighborhood Hits	763
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

NEK3_HUMAN
NC score	0.931801 (rank : 88)	θ value	3.62785e-25 (rank : 93)
Query Neighborhood Hits	1275	Target Neighborhood Hits	865	Shared Neighborhood Hits	827
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

ULK3_HUMAN
NC score	0.931415 (rank : 89)	θ value	5.07402e-19 (rank : 174)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	818
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

E2AK2_MOUSE
NC score	0.931064 (rank : 90)	θ value	6.20254e-17 (rank : 244)
Query Neighborhood Hits	1275	Target Neighborhood Hits	864	Shared Neighborhood Hits	827
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

NEK3_MOUSE
NC score	0.930770 (rank : 91)	θ value	1.47289e-26 (rank : 88)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	825
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

HIPK4_HUMAN
NC score	0.929970 (rank : 92)	θ value	6.40375e-22 (rank : 117)
Query Neighborhood Hits	1275	Target Neighborhood Hits	799	Shared Neighborhood Hits	780
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

NEK6_HUMAN
NC score	0.929884 (rank : 93)	θ value	6.85773e-16 (rank : 305)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	829
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.929855 (rank : 94)	θ value	4.02038e-16 (rank : 285)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	829
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

M3K1_MOUSE
NC score	0.929775 (rank : 95)	θ value	2.69047e-20 (rank : 141)
Query Neighborhood Hits	1275	Target Neighborhood Hits	952	Shared Neighborhood Hits	846
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

NEK7_MOUSE
NC score	0.926055 (rank : 96)	θ value	1.058e-16 (rank : 255)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	829
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_HUMAN
NC score	0.926024 (rank : 97)	θ value	7.32683e-18 (rank : 214)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	828
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

ULK3_MOUSE
NC score	0.925827 (rank : 98)	θ value	5.99374e-20 (rank : 153)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	826
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

STK11_HUMAN
NC score	0.925287 (rank : 99)	θ value	4.29542e-18 (rank : 206)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	822
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

NEK2_HUMAN
NC score	0.925009 (rank : 100)	θ value	2.87452e-22 (rank : 116)
Query Neighborhood Hits	1275	Target Neighborhood Hits	908	Shared Neighborhood Hits	819
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
NC score	0.924920 (rank : 101)	θ value	3.17815e-21 (rank : 129)
Query Neighborhood Hits	1275	Target Neighborhood Hits	876	Shared Neighborhood Hits	813
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

E2AK2_HUMAN
NC score	0.924647 (rank : 102)	θ value	3.88503e-19 (rank : 166)
Query Neighborhood Hits	1275	Target Neighborhood Hits	856	Shared Neighborhood Hits	820
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

CSK22_MOUSE
NC score	0.924564 (rank : 103)	θ value	5.06226e-27 (rank : 85)
Query Neighborhood Hits	1275	Target Neighborhood Hits	758	Shared Neighborhood Hits	755
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

DYRK3_HUMAN
NC score	0.924478 (rank : 104)	θ value	4.73814e-25 (rank : 94)
Query Neighborhood Hits	1275	Target Neighborhood Hits	798	Shared Neighborhood Hits	784
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

CSK22_HUMAN
NC score	0.924299 (rank : 105)	θ value	1.12775e-26 (rank : 86)
Query Neighborhood Hits	1275	Target Neighborhood Hits	758	Shared Neighborhood Hits	755
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

ULK2_MOUSE
NC score	0.923848 (rank : 106)	θ value	8.10077e-17 (rank : 254)
Query Neighborhood Hits	1275	Target Neighborhood Hits	943	Shared Neighborhood Hits	851
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

CHK1_MOUSE
NC score	0.923717 (rank : 107)	θ value	9.24701e-21 (rank : 135)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	822
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

M3K6_HUMAN
NC score	0.923254 (rank : 108)	θ value	1.42661e-21 (rank : 119)
Query Neighborhood Hits	1275	Target Neighborhood Hits	889	Shared Neighborhood Hits	843
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M3K4_HUMAN
NC score	0.923213 (rank : 109)	θ value	1.09232e-21 (rank : 118)
Query Neighborhood Hits	1275	Target Neighborhood Hits	911	Shared Neighborhood Hits	837
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

CHK1_HUMAN
NC score	0.923070 (rank : 110)	θ value	3.17815e-21 (rank : 128)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	823
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

ULK2_HUMAN
NC score	0.922610 (rank : 111)	θ value	1.80466e-16 (rank : 266)
Query Neighborhood Hits	1275	Target Neighborhood Hits	979	Shared Neighborhood Hits	847
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

M3K4_MOUSE
NC score	0.922589 (rank : 112)	θ value	2.06002e-20 (rank : 140)
Query Neighborhood Hits	1275	Target Neighborhood Hits	924	Shared Neighborhood Hits	837
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K15_HUMAN
NC score	0.922108 (rank : 113)	θ value	4.58923e-20 (rank : 146)
Query Neighborhood Hits	1275	Target Neighborhood Hits	914	Shared Neighborhood Hits	836
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

NEK1_HUMAN
NC score	0.921940 (rank : 114)	θ value	9.24701e-21 (rank : 136)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1129	Shared Neighborhood Hits	861
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK4_MOUSE
NC score	0.921856 (rank : 115)	θ value	3.28887e-18 (rank : 199)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	844
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK1_MOUSE
NC score	0.920912 (rank : 116)	θ value	1.86321e-21 (rank : 125)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1311	Shared Neighborhood Hits	882
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

M3K3_HUMAN
NC score	0.920812 (rank : 117)	θ value	1.33526e-19 (rank : 159)
Query Neighborhood Hits	1275	Target Neighborhood Hits	885	Shared Neighborhood Hits	840
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

ULK1_HUMAN
NC score	0.920675 (rank : 118)	θ value	8.65492e-19 (rank : 183)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1121	Shared Neighborhood Hits	870
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

NEK4_HUMAN
NC score	0.920666 (rank : 119)	θ value	3.28887e-18 (rank : 198)
Query Neighborhood Hits	1275	Target Neighborhood Hits	883	Shared Neighborhood Hits	836
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

PLK4_MOUSE
NC score	0.920351 (rank : 120)	θ value	7.82807e-20 (rank : 156)
Query Neighborhood Hits	1275	Target Neighborhood Hits	879	Shared Neighborhood Hits	836
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

AURKC_HUMAN
NC score	0.920245 (rank : 121)	θ value	2.43343e-21 (rank : 127)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	829
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

STK6_HUMAN
NC score	0.920195 (rank : 122)	θ value	1.47289e-26 (rank : 89)
Query Neighborhood Hits	1275	Target Neighborhood Hits	916	Shared Neighborhood Hits	843
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

M3K3_MOUSE
NC score	0.920078 (rank : 123)	θ value	7.82807e-20 (rank : 154)
Query Neighborhood Hits	1275	Target Neighborhood Hits	876	Shared Neighborhood Hits	836
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K5_MOUSE
NC score	0.919702 (rank : 124)	θ value	8.65492e-19 (rank : 179)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	832
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_HUMAN
NC score	0.919678 (rank : 125)	θ value	8.65492e-19 (rank : 178)
Query Neighborhood Hits	1275	Target Neighborhood Hits	868	Shared Neighborhood Hits	831
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K2_HUMAN
NC score	0.919589 (rank : 126)	θ value	4.58923e-20 (rank : 147)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

ULK1_MOUSE
NC score	0.919416 (rank : 127)	θ value	3.88503e-19 (rank : 169)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1214	Shared Neighborhood Hits	892
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

STK6_MOUSE
NC score	0.919395 (rank : 128)	θ value	4.01107e-24 (rank : 96)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	837
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

AURKC_MOUSE
NC score	0.919154 (rank : 129)	θ value	1.5242e-23 (rank : 101)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	828
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

DYRK2_HUMAN
NC score	0.918510 (rank : 130)	θ value	1.5242e-23 (rank : 103)
Query Neighborhood Hits	1275	Target Neighborhood Hits	799	Shared Neighborhood Hits	783
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

PLK4_HUMAN
NC score	0.918409 (rank : 131)	θ value	3.88503e-19 (rank : 168)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	833
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

NEK11_MOUSE
NC score	0.917985 (rank : 132)	θ value	1.16975e-15 (rank : 315)
Query Neighborhood Hits	1275	Target Neighborhood Hits	875	Shared Neighborhood Hits	825
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PAK2_HUMAN
NC score	0.917954 (rank : 133)	θ value	1.33526e-19 (rank : 162)
Query Neighborhood Hits	1275	Target Neighborhood Hits	862	Shared Neighborhood Hits	835
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
NC score	0.917762 (rank : 134)	θ value	5.07402e-19 (rank : 172)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	832
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

AURKB_HUMAN
NC score	0.917664 (rank : 135)	θ value	1.6852e-22 (rank : 115)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	826
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
NC score	0.917440 (rank : 136)	θ value	5.79196e-23 (rank : 110)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	830
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

NUAK2_HUMAN
NC score	0.917198 (rank : 137)	θ value	4.43474e-23 (rank : 108)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	836
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

M3K2_MOUSE
NC score	0.917062 (rank : 138)	θ value	2.97466e-19 (rank : 165)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	824
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

PAK6_HUMAN
NC score	0.916900 (rank : 139)	θ value	3.28887e-18 (rank : 200)
Query Neighborhood Hits	1275	Target Neighborhood Hits	915	Shared Neighborhood Hits	849
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
NC score	0.916706 (rank : 140)	θ value	1.02238e-19 (rank : 157)
Query Neighborhood Hits	1275	Target Neighborhood Hits	875	Shared Neighborhood Hits	832
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

NEK11_HUMAN
NC score	0.916634 (rank : 141)	θ value	2.20605e-14 (rank : 379)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1043	Shared Neighborhood Hits	843
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PAK7_MOUSE
NC score	0.916563 (rank : 142)	θ value	1.02238e-19 (rank : 158)
Query Neighborhood Hits	1275	Target Neighborhood Hits	875	Shared Neighborhood Hits	830
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

STK33_HUMAN
NC score	0.916547 (rank : 143)	θ value	1.2077e-20 (rank : 139)
Query Neighborhood Hits	1275	Target Neighborhood Hits	879	Shared Neighborhood Hits	827
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

NUAK1_HUMAN
NC score	0.916427 (rank : 144)	θ value	9.87957e-23 (rank : 113)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	836
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

PAK1_HUMAN
NC score	0.916349 (rank : 145)	θ value	2.59989e-23 (rank : 104)
Query Neighborhood Hits	1275	Target Neighborhood Hits	873	Shared Neighborhood Hits	839
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

NUAK1_MOUSE
NC score	0.916333 (rank : 146)	θ value	4.43474e-23 (rank : 107)
Query Neighborhood Hits	1275	Target Neighborhood Hits	881	Shared Neighborhood Hits	836
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

STK4_MOUSE
NC score	0.915860 (rank : 147)	θ value	3.07116e-24 (rank : 95)
Query Neighborhood Hits	1275	Target Neighborhood Hits	873	Shared Neighborhood Hits	825
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

PAK1_MOUSE
NC score	0.915741 (rank : 148)	θ value	9.87957e-23 (rank : 114)
Query Neighborhood Hits	1275	Target Neighborhood Hits	878	Shared Neighborhood Hits	840
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

STK4_HUMAN
NC score	0.915701 (rank : 149)	θ value	5.23862e-24 (rank : 98)
Query Neighborhood Hits	1275	Target Neighborhood Hits	870	Shared Neighborhood Hits	825
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

PDK1L_MOUSE
NC score	0.915451 (rank : 150)	θ value	7.84624e-12 (rank : 517)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	809
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PLK3_HUMAN
NC score	0.915303 (rank : 151)	θ value	3.51386e-20 (rank : 143)
Query Neighborhood Hits	1275	Target Neighborhood Hits	865	Shared Neighborhood Hits	827
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

NUAK2_MOUSE
NC score	0.915266 (rank : 152)	θ value	6.84181e-24 (rank : 99)
Query Neighborhood Hits	1275	Target Neighborhood Hits	878	Shared Neighborhood Hits	835
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

PAK3_HUMAN
NC score	0.915219 (rank : 153)	θ value	9.24701e-21 (rank : 137)
Query Neighborhood Hits	1275	Target Neighborhood Hits	887	Shared Neighborhood Hits	842
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PDK1L_HUMAN
NC score	0.915191 (rank : 154)	θ value	2.28291e-11 (rank : 542)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	809
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PAK3_MOUSE
NC score	0.915162 (rank : 155)	θ value	3.88503e-19 (rank : 167)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	834
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
NC score	0.914816 (rank : 156)	θ value	2.5182e-18 (rank : 196)
Query Neighborhood Hits	1275	Target Neighborhood Hits	924	Shared Neighborhood Hits	847
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

STK3_MOUSE
NC score	0.914535 (rank : 157)	θ value	7.56453e-23 (rank : 112)
Query Neighborhood Hits	1275	Target Neighborhood Hits	869	Shared Neighborhood Hits	825
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

IKKB_HUMAN
NC score	0.914369 (rank : 158)	θ value	7.09661e-13 (rank : 467)
Query Neighborhood Hits	1275	Target Neighborhood Hits	980	Shared Neighborhood Hits	835
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

YSK4_HUMAN
NC score	0.914286 (rank : 159)	θ value	4.91457e-14 (rank : 401)
Query Neighborhood Hits	1275	Target Neighborhood Hits	921	Shared Neighborhood Hits	838
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

STK3_HUMAN
NC score	0.914155 (rank : 160)	θ value	2.59989e-23 (rank : 105)
Query Neighborhood Hits	1275	Target Neighborhood Hits	861	Shared Neighborhood Hits	822
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

PLK3_MOUSE
NC score	0.914133 (rank : 161)	θ value	1.13037e-18 (rank : 188)
Query Neighborhood Hits	1275	Target Neighborhood Hits	863	Shared Neighborhood Hits	829
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PAK4_MOUSE
NC score	0.913838 (rank : 162)	θ value	1.13037e-18 (rank : 187)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1098	Shared Neighborhood Hits	865
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

SNRK_MOUSE
NC score	0.913030 (rank : 163)	θ value	4.43474e-23 (rank : 109)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	814
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

IKKB_MOUSE
NC score	0.912551 (rank : 164)	θ value	1.33837e-11 (rank : 528)
Query Neighborhood Hits	1275	Target Neighborhood Hits	984	Shared Neighborhood Hits	830
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

SNRK_HUMAN
NC score	0.912406 (rank : 165)	θ value	3.39556e-23 (rank : 106)
Query Neighborhood Hits	1275	Target Neighborhood Hits	855	Shared Neighborhood Hits	815
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

MP2K2_HUMAN
NC score	0.911517 (rank : 166)	θ value	2.69671e-12 (rank : 490)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	815
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
NC score	0.911413 (rank : 167)	θ value	1.42992e-13 (rank : 429)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	814
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K1_HUMAN
NC score	0.911186 (rank : 168)	θ value	2.69671e-12 (rank : 488)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	814
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
NC score	0.910837 (rank : 169)	θ value	2.69671e-12 (rank : 489)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	814
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

NEK8_HUMAN
NC score	0.910663 (rank : 170)	θ value	2.7842e-17 (rank : 236)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	826
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

CI096_HUMAN
NC score	0.910655 (rank : 171)	θ value	1.99992e-07 (rank : 704)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	799
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

NEK8_MOUSE
NC score	0.910585 (rank : 172)	θ value	1.63225e-17 (rank : 224)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	825
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

STK24_HUMAN
NC score	0.910555 (rank : 173)	θ value	3.28887e-18 (rank : 201)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
NC score	0.910099 (rank : 174)	θ value	9.56915e-18 (rank : 218)
Query Neighborhood Hits	1275	Target Neighborhood Hits	856	Shared Neighborhood Hits	829
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK35_HUMAN
NC score	0.909939 (rank : 175)	θ value	4.76016e-09 (rank : 652)
Query Neighborhood Hits	1275	Target Neighborhood Hits	825	Shared Neighborhood Hits	810
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

M4K1_HUMAN
NC score	0.909892 (rank : 176)	θ value	1.74391e-19 (rank : 164)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	833
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
NC score	0.909806 (rank : 177)	θ value	5.60996e-18 (rank : 208)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	828
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

DYR1B_MOUSE
NC score	0.909723 (rank : 178)	θ value	5.23862e-24 (rank : 97)
Query Neighborhood Hits	1275	Target Neighborhood Hits	799	Shared Neighborhood Hits	769
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

MST4_HUMAN
NC score	0.909599 (rank : 179)	θ value	7.82807e-20 (rank : 155)
Query Neighborhood Hits	1275	Target Neighborhood Hits	852	Shared Neighborhood Hits	827
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
NC score	0.909536 (rank : 180)	θ value	1.13037e-18 (rank : 186)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	828
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

STK25_HUMAN
NC score	0.908682 (rank : 181)	θ value	8.10077e-17 (rank : 253)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	828
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

IKKA_MOUSE
NC score	0.908653 (rank : 182)	θ value	5.62301e-10 (rank : 609)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	826
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

PASK_MOUSE
NC score	0.908320 (rank : 183)	θ value	1.29331e-14 (rank : 370)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	822
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

IKKA_HUMAN
NC score	0.908320 (rank : 184)	θ value	2.13673e-09 (rank : 632)
Query Neighborhood Hits	1275	Target Neighborhood Hits	863	Shared Neighborhood Hits	827
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

STK25_MOUSE
NC score	0.908213 (rank : 185)	θ value	1.38178e-16 (rank : 260)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	827
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

KKCC2_MOUSE
NC score	0.907906 (rank : 186)	θ value	5.8054e-15 (rank : 355)
Query Neighborhood Hits	1275	Target Neighborhood Hits	855	Shared Neighborhood Hits	821
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_HUMAN
NC score	0.907678 (rank : 187)	θ value	5.8054e-15 (rank : 354)
Query Neighborhood Hits	1275	Target Neighborhood Hits	852	Shared Neighborhood Hits	819
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

PLK2_HUMAN
NC score	0.907454 (rank : 188)	θ value	1.38178e-16 (rank : 257)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	830
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

SN1L1_MOUSE
NC score	0.907384 (rank : 189)	θ value	1.86321e-21 (rank : 126)
Query Neighborhood Hits	1275	Target Neighborhood Hits	895	Shared Neighborhood Hits	837
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

BRSK1_HUMAN
NC score	0.907381 (rank : 190)	θ value	6.20254e-17 (rank : 243)
Query Neighborhood Hits	1275	Target Neighborhood Hits	942	Shared Neighborhood Hits	852
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

PLK2_MOUSE
NC score	0.907345 (rank : 191)	θ value	1.38178e-16 (rank : 258)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	828
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

TSSK6_MOUSE
NC score	0.907157 (rank : 192)	θ value	5.43371e-13 (rank : 462)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	813
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

CHK2_MOUSE
NC score	0.906909 (rank : 193)	θ value	1.13037e-18 (rank : 184)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	825
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

MARK4_HUMAN
NC score	0.906888 (rank : 194)	θ value	4.58923e-20 (rank : 148)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	844
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
NC score	0.906727 (rank : 195)	θ value	1.33526e-19 (rank : 161)
Query Neighborhood Hits	1275	Target Neighborhood Hits	898	Shared Neighborhood Hits	842
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

PRP4B_HUMAN
NC score	0.906715 (rank : 196)	θ value	1.42661e-21 (rank : 120)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1030	Shared Neighborhood Hits	822
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

TAOK2_HUMAN
NC score	0.906514 (rank : 197)	θ value	3.51386e-20 (rank : 144)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1172	Shared Neighborhood Hits	862
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TSSK6_HUMAN
NC score	0.906102 (rank : 198)	θ value	2.0648e-12 (rank : 485)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	814
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

STK39_MOUSE
NC score	0.905999 (rank : 199)	θ value	3.40345e-15 (rank : 346)
Query Neighborhood Hits	1275	Target Neighborhood Hits	915	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

PLK1_MOUSE
NC score	0.905859 (rank : 200)	θ value	9.56915e-18 (rank : 217)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	825
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

AAPK1_HUMAN
NC score	0.905851 (rank : 201)	θ value	6.20254e-17 (rank : 242)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	822
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

MP2K5_MOUSE
NC score	0.905759 (rank : 202)	θ value	1.33837e-11 (rank : 530)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	822
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

STK39_HUMAN
NC score	0.905706 (rank : 203)	θ value	3.40345e-15 (rank : 345)
Query Neighborhood Hits	1275	Target Neighborhood Hits	882	Shared Neighborhood Hits	832
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

DCAK3_HUMAN
NC score	0.905689 (rank : 204)	θ value	5.07402e-19 (rank : 170)
Query Neighborhood Hits	1275	Target Neighborhood Hits	888	Shared Neighborhood Hits	839
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DYR1B_HUMAN
NC score	0.905656 (rank : 205)	θ value	7.56453e-23 (rank : 111)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	772
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

BRSK2_HUMAN
NC score	0.905617 (rank : 206)	θ value	1.99529e-15 (rank : 322)
Query Neighborhood Hits	1275	Target Neighborhood Hits	897	Shared Neighborhood Hits	835
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

NEK9_MOUSE
NC score	0.905597 (rank : 207)	θ value	2.13179e-17 (rank : 232)
Query Neighborhood Hits	1275	Target Neighborhood Hits	890	Shared Neighborhood Hits	832
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

ST17B_MOUSE
NC score	0.905464 (rank : 208)	θ value	1.99529e-15 (rank : 327)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	816
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

HUNK_HUMAN
NC score	0.905317 (rank : 209)	θ value	6.85773e-16 (rank : 302)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	834
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

AAPK1_MOUSE
NC score	0.905313 (rank : 210)	θ value	2.35696e-16 (rank : 267)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	822
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

DCAK3_MOUSE
NC score	0.905163 (rank : 211)	θ value	1.86321e-21 (rank : 124)
Query Neighborhood Hits	1275	Target Neighborhood Hits	922	Shared Neighborhood Hits	837
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

NEK9_HUMAN
NC score	0.905086 (rank : 212)	θ value	2.13179e-17 (rank : 231)
Query Neighborhood Hits	1275	Target Neighborhood Hits	900	Shared Neighborhood Hits	833
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

HUNK_MOUSE
NC score	0.905052 (rank : 213)	θ value	2.60593e-15 (rank : 333)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	835
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

PLK1_HUMAN
NC score	0.905045 (rank : 214)	θ value	3.07829e-16 (rank : 278)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	824
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KPCD2_HUMAN
NC score	0.904873 (rank : 215)	θ value	3.40345e-15 (rank : 340)
Query Neighborhood Hits	1275	Target Neighborhood Hits	910	Shared Neighborhood Hits	828
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

M4K3_HUMAN
NC score	0.904707 (rank : 216)	θ value	5.07402e-19 (rank : 171)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	830
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

PRP4B_MOUSE
NC score	0.904654 (rank : 217)	θ value	1.42661e-21 (rank : 121)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1040	Shared Neighborhood Hits	823
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

OXSR1_HUMAN
NC score	0.904377 (rank : 218)	θ value	1.42992e-13 (rank : 430)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	835
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
NC score	0.904172 (rank : 219)	θ value	1.86753e-13 (rank : 436)
Query Neighborhood Hits	1275	Target Neighborhood Hits	865	Shared Neighborhood Hits	833
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PHKG2_MOUSE
NC score	0.903947 (rank : 220)	θ value	1.2077e-20 (rank : 138)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	826
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

IKKE_MOUSE
NC score	0.903872 (rank : 221)	θ value	7.84624e-12 (rank : 515)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	803
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

CHK2_HUMAN
NC score	0.903463 (rank : 222)	θ value	1.24977e-17 (rank : 220)
Query Neighborhood Hits	1275	Target Neighborhood Hits	859	Shared Neighborhood Hits	824
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

SN1L1_HUMAN
NC score	0.903237 (rank : 223)	θ value	7.0802e-21 (rank : 133)
Query Neighborhood Hits	1275	Target Neighborhood Hits	911	Shared Neighborhood Hits	842
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

TSSK4_MOUSE
NC score	0.903172 (rank : 224)	θ value	9.26847e-13 (rank : 474)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	820
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

PDPK1_MOUSE
NC score	0.903063 (rank : 225)	θ value	1.92812e-18 (rank : 192)
Query Neighborhood Hits	1275	Target Neighborhood Hits	852	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PDPK1_HUMAN
NC score	0.902913 (rank : 226)	θ value	1.92812e-18 (rank : 191)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	830
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

KKCC1_MOUSE
NC score	0.902862 (rank : 227)	θ value	6.41864e-14 (rank : 406)
Query Neighborhood Hits	1275	Target Neighborhood Hits	866	Shared Neighborhood Hits	825
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MARK3_MOUSE
NC score	0.902822 (rank : 228)	θ value	2.13179e-17 (rank : 229)
Query Neighborhood Hits	1275	Target Neighborhood Hits	919	Shared Neighborhood Hits	846
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

KKCC1_HUMAN
NC score	0.902811 (rank : 229)	θ value	2.60593e-15 (rank : 334)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	825
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MP2K5_HUMAN
NC score	0.902643 (rank : 230)	θ value	1.133e-10 (rank : 575)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

IKKE_HUMAN
NC score	0.902380 (rank : 231)	θ value	1.02475e-11 (rank : 524)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	805
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

PHKG2_HUMAN
NC score	0.902365 (rank : 232)	θ value	3.51386e-20 (rank : 142)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	825
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

MARK2_HUMAN
NC score	0.902231 (rank : 233)	θ value	1.33526e-19 (rank : 160)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1056	Shared Neighborhood Hits	877
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

PASK_HUMAN
NC score	0.902152 (rank : 234)	θ value	2.69671e-12 (rank : 491)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	813
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

DYRK4_HUMAN
NC score	0.901789 (rank : 235)	θ value	3.87602e-27 (rank : 84)
Query Neighborhood Hits	1275	Target Neighborhood Hits	750	Shared Neighborhood Hits	740
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

MYLK2_HUMAN
NC score	0.901607 (rank : 236)	θ value	1.86753e-13 (rank : 435)
Query Neighborhood Hits	1275	Target Neighborhood Hits	920	Shared Neighborhood Hits	830
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

DAPK3_HUMAN
NC score	0.901159 (rank : 237)	θ value	2.7842e-17 (rank : 233)
Query Neighborhood Hits	1275	Target Neighborhood Hits	945	Shared Neighborhood Hits	823
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

AAPK2_HUMAN
NC score	0.901077 (rank : 238)	θ value	1.63225e-17 (rank : 221)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	822
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

KCC1A_HUMAN
NC score	0.901075 (rank : 239)	θ value	1.63225e-17 (rank : 222)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	826
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
NC score	0.901057 (rank : 240)	θ value	2.13179e-17 (rank : 225)
Query Neighborhood Hits	1275	Target Neighborhood Hits	845	Shared Neighborhood Hits	826
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KPCD1_HUMAN
NC score	0.901026 (rank : 241)	θ value	1.99529e-15 (rank : 325)
Query Neighborhood Hits	1275	Target Neighborhood Hits	901	Shared Neighborhood Hits	822
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

SN1L2_HUMAN
NC score	0.900937 (rank : 242)	θ value	5.07402e-19 (rank : 173)
Query Neighborhood Hits	1275	Target Neighborhood Hits	964	Shared Neighborhood Hits	879
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

KPCD1_MOUSE
NC score	0.900621 (rank : 243)	θ value	8.95645e-16 (rank : 311)
Query Neighborhood Hits	1275	Target Neighborhood Hits	891	Shared Neighborhood Hits	821
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MARK1_HUMAN
NC score	0.900370 (rank : 244)	θ value	1.63225e-17 (rank : 223)
Query Neighborhood Hits	1275	Target Neighborhood Hits	887	Shared Neighborhood Hits	837
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
NC score	0.900323 (rank : 245)	θ value	4.74913e-17 (rank : 240)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	840
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

SBK1_MOUSE
NC score	0.900295 (rank : 246)	θ value	2.69671e-12 (rank : 493)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	804
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

MARK2_MOUSE
NC score	0.900127 (rank : 247)	θ value	6.62687e-19 (rank : 175)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1018	Shared Neighborhood Hits	873
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

DAPK3_MOUSE
NC score	0.900076 (rank : 248)	θ value	6.85773e-16 (rank : 300)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	814
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

SN1L2_MOUSE
NC score	0.899986 (rank : 249)	θ value	1.92812e-18 (rank : 193)
Query Neighborhood Hits	1275	Target Neighborhood Hits	944	Shared Neighborhood Hits	867
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

M4K2_MOUSE
NC score	0.899833 (rank : 250)	θ value	5.99374e-20 (rank : 152)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	815
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

ST17A_HUMAN
NC score	0.899589 (rank : 251)	θ value	5.8054e-15 (rank : 358)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	809
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
NC score	0.899493 (rank : 252)	θ value	3.18553e-13 (rank : 448)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	812
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

TSSK1_MOUSE
NC score	0.899390 (rank : 253)	θ value	1.80466e-16 (rank : 265)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	815
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MELK_MOUSE
NC score	0.899266 (rank : 254)	θ value	3.40345e-15 (rank : 342)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	825
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MP2K7_HUMAN
NC score	0.899257 (rank : 255)	θ value	1.33837e-11 (rank : 531)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

KCC1G_MOUSE
NC score	0.899192 (rank : 256)	θ value	3.07829e-16 (rank : 277)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	826
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

HIPK3_MOUSE
NC score	0.898935 (rank : 257)	θ value	3.07829e-16 (rank : 276)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	795
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

STK16_HUMAN
NC score	0.898906 (rank : 258)	θ value	1.17247e-07 (rank : 697)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	812
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

M4K2_HUMAN
NC score	0.898885 (rank : 259)	θ value	5.99374e-20 (rank : 151)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

KCC1G_HUMAN
NC score	0.898634 (rank : 260)	θ value	4.02038e-16 (rank : 281)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	823
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

M4K5_MOUSE
NC score	0.898412 (rank : 261)	θ value	5.60996e-18 (rank : 209)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	818
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

DAPK2_MOUSE
NC score	0.898024 (rank : 262)	θ value	3.76295e-14 (rank : 392)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	816
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

KPCD3_MOUSE
NC score	0.897472 (rank : 263)	θ value	2.20605e-14 (rank : 376)
Query Neighborhood Hits	1275	Target Neighborhood Hits	901	Shared Neighborhood Hits	821
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

SBK1_HUMAN
NC score	0.897440 (rank : 264)	θ value	5.43371e-13 (rank : 460)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	808
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

HIPK3_HUMAN
NC score	0.897372 (rank : 265)	θ value	2.35696e-16 (rank : 269)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	792
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

M4K5_HUMAN
NC score	0.897183 (rank : 266)	θ value	7.32683e-18 (rank : 213)
Query Neighborhood Hits	1275	Target Neighborhood Hits	845	Shared Neighborhood Hits	820
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MP2K3_HUMAN
NC score	0.897152 (rank : 267)	θ value	4.30538e-10 (rank : 606)
Query Neighborhood Hits	1275	Target Neighborhood Hits	825	Shared Neighborhood Hits	810
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

KPCD3_HUMAN
NC score	0.897118 (rank : 268)	θ value	4.91457e-14 (rank : 399)
Query Neighborhood Hits	1275	Target Neighborhood Hits	895	Shared Neighborhood Hits	821
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

DAPK2_HUMAN
NC score	0.896921 (rank : 269)	θ value	9.90251e-15 (rank : 364)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	812
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MP2K3_MOUSE
NC score	0.896885 (rank : 270)	θ value	4.30538e-10 (rank : 607)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	811
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

STK16_MOUSE
NC score	0.896801 (rank : 271)	θ value	1.38499e-08 (rank : 663)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	811
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

MELK_HUMAN
NC score	0.896760 (rank : 272)	θ value	5.43371e-13 (rank : 457)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	823
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

KCC4_MOUSE
NC score	0.896610 (rank : 273)	θ value	7.32683e-18 (rank : 212)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	835
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

M3K14_HUMAN
NC score	0.896271 (rank : 274)	θ value	1.74796e-11 (rank : 535)
Query Neighborhood Hits	1275	Target Neighborhood Hits	887	Shared Neighborhood Hits	834
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

KPSH1_HUMAN
NC score	0.896183 (rank : 275)	θ value	6.85773e-16 (rank : 304)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	820
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
NC score	0.896108 (rank : 276)	θ value	2.35696e-16 (rank : 270)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	819
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KCC4_HUMAN
NC score	0.895861 (rank : 277)	θ value	1.16975e-15 (rank : 314)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	824
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

HIPK1_HUMAN
NC score	0.895852 (rank : 278)	θ value	7.32683e-18 (rank : 211)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	785
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.895786 (rank : 279)	θ value	9.56915e-18 (rank : 215)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	785
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

NIM1_MOUSE
NC score	0.895461 (rank : 280)	θ value	1.02475e-11 (rank : 525)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

TSSK4_HUMAN
NC score	0.895274 (rank : 281)	θ value	1.47974e-10 (rank : 582)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	819
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

DYR1A_MOUSE
NC score	0.895114 (rank : 282)	θ value	7.0802e-21 (rank : 132)
Query Neighborhood Hits	1275	Target Neighborhood Hits	762	Shared Neighborhood Hits	745
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1A_HUMAN
NC score	0.895049 (rank : 283)	θ value	7.0802e-21 (rank : 131)
Query Neighborhood Hits	1275	Target Neighborhood Hits	764	Shared Neighborhood Hits	745
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

MARK3_HUMAN
NC score	0.894542 (rank : 284)	θ value	2.60593e-15 (rank : 335)
Query Neighborhood Hits	1275	Target Neighborhood Hits	893	Shared Neighborhood Hits	834
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

KCC2G_HUMAN
NC score	0.894400 (rank : 285)	θ value	4.02038e-16 (rank : 282)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	819
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

MP2K6_MOUSE
NC score	0.894363 (rank : 286)	θ value	2.52405e-10 (rank : 596)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	815
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

NIM1_HUMAN
NC score	0.894353 (rank : 287)	θ value	1.74796e-11 (rank : 536)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	825
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KCC2G_MOUSE
NC score	0.894333 (rank : 288)	θ value	4.02038e-16 (rank : 283)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	818
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

PHKG1_HUMAN
NC score	0.894147 (rank : 289)	θ value	2.20605e-14 (rank : 380)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	821
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

MP2K6_HUMAN
NC score	0.894007 (rank : 290)	θ value	3.29651e-10 (rank : 601)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	814
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

PHKG1_MOUSE
NC score	0.893974 (rank : 291)	θ value	5.8054e-15 (rank : 357)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	820
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

KPSH2_HUMAN
NC score	0.893799 (rank : 292)	θ value	3.40345e-15 (rank : 341)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	807
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

ST32A_MOUSE
NC score	0.893745 (rank : 293)	θ value	5.60996e-18 (rank : 210)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

HIPK2_HUMAN
NC score	0.893734 (rank : 294)	θ value	5.99374e-20 (rank : 150)
Query Neighborhood Hits	1275	Target Neighborhood Hits	845	Shared Neighborhood Hits	785
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

KCC1B_MOUSE
NC score	0.893662 (rank : 295)	θ value	4.16044e-13 (rank : 450)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

K0999_HUMAN
NC score	0.893633 (rank : 296)	θ value	1.47631e-18 (rank : 189)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KCC2D_HUMAN
NC score	0.893508 (rank : 297)	θ value	2.13179e-17 (rank : 226)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	814
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

K0999_MOUSE
NC score	0.893470 (rank : 298)	θ value	2.5182e-18 (rank : 194)
Query Neighborhood Hits	1275	Target Neighborhood Hits	931	Shared Neighborhood Hits	842
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KCC1D_MOUSE
NC score	0.893455 (rank : 299)	θ value	8.10077e-17 (rank : 249)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	821
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.893422 (rank : 300)	θ value	1.80466e-16 (rank : 263)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	821
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

HIPK2_MOUSE
NC score	0.893329 (rank : 301)	θ value	1.13037e-18 (rank : 185)
Query Neighborhood Hits	1275	Target Neighborhood Hits	871	Shared Neighborhood Hits	793
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

TAOK2_MOUSE
NC score	0.893068 (rank : 302)	θ value	3.51386e-20 (rank : 145)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1373	Shared Neighborhood Hits	878
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

KCC2A_HUMAN
NC score	0.893019 (rank : 303)	θ value	4.74913e-17 (rank : 237)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	812
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

ULK4_MOUSE
NC score	0.892795 (rank : 304)	θ value	1.42992e-13 (rank : 432)
Query Neighborhood Hits	1275	Target Neighborhood Hits	793	Shared Neighborhood Hits	766
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

TSSK2_HUMAN
NC score	0.892656 (rank : 305)	θ value	1.99529e-15 (rank : 330)
Query Neighborhood Hits	1275	Target Neighborhood Hits	826	Shared Neighborhood Hits	810
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

KCC1B_HUMAN
NC score	0.892465 (rank : 306)	θ value	1.2105e-12 (rank : 478)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	823
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

TLK2_HUMAN
NC score	0.892283 (rank : 307)	θ value	8.65492e-19 (rank : 181)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1044	Shared Neighborhood Hits	797
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

MP2K4_MOUSE
NC score	0.892141 (rank : 308)	θ value	4.76016e-09 (rank : 648)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	817
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K4_HUMAN
NC score	0.891933 (rank : 309)	θ value	4.76016e-09 (rank : 647)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	817
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

KCC2A_MOUSE
NC score	0.891908 (rank : 310)	θ value	5.60996e-18 (rank : 207)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	810
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
NC score	0.891703 (rank : 311)	θ value	3.28887e-18 (rank : 197)
Query Neighborhood Hits	1275	Target Neighborhood Hits	866	Shared Neighborhood Hits	824
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

PMYT1_MOUSE
NC score	0.891531 (rank : 312)	θ value	1.133e-10 (rank : 576)
Query Neighborhood Hits	1275	Target Neighborhood Hits	910	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

M3K14_MOUSE
NC score	0.891452 (rank : 313)	θ value	3.52202e-12 (rank : 497)
Query Neighborhood Hits	1275	Target Neighborhood Hits	889	Shared Neighborhood Hits	816
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

TLK2_MOUSE
NC score	0.890032 (rank : 314)	θ value	8.65492e-19 (rank : 182)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1088	Shared Neighborhood Hits	804
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

ST32A_HUMAN
NC score	0.889868 (rank : 315)	θ value	8.10077e-17 (rank : 252)
Query Neighborhood Hits	1275	Target Neighborhood Hits	834	Shared Neighborhood Hits	822
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

TBK1_HUMAN
NC score	0.889116 (rank : 316)	θ value	4.76016e-09 (rank : 653)
Query Neighborhood Hits	1275	Target Neighborhood Hits	861	Shared Neighborhood Hits	799
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

KCC2B_MOUSE
NC score	0.889079 (rank : 317)	θ value	2.7842e-17 (rank : 234)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	813
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

E2AK1_MOUSE
NC score	0.888902 (rank : 318)	θ value	1.80886e-08 (rank : 667)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	805
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

ST32C_MOUSE
NC score	0.888754 (rank : 319)	θ value	6.85773e-16 (rank : 307)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	812
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

TSSK3_MOUSE
NC score	0.888671 (rank : 320)	θ value	6.85773e-16 (rank : 308)
Query Neighborhood Hits	1275	Target Neighborhood Hits	806	Shared Neighborhood Hits	791
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

DCAK1_HUMAN
NC score	0.888563 (rank : 321)	θ value	8.67504e-11 (rank : 567)
Query Neighborhood Hits	1275	Target Neighborhood Hits	877	Shared Neighborhood Hits	831
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

MINK1_HUMAN
NC score	0.888327 (rank : 322)	θ value	2.60593e-15 (rank : 336)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1477	Shared Neighborhood Hits	911
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
NC score	0.888283 (rank : 323)	θ value	3.40345e-15 (rank : 343)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1451	Shared Neighborhood Hits	906
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

TLK1_MOUSE
NC score	0.888182 (rank : 324)	θ value	1.99529e-15 (rank : 329)
Query Neighborhood Hits	1275	Target Neighborhood Hits	947	Shared Neighborhood Hits	783
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK1_HUMAN
NC score	0.888045 (rank : 325)	θ value	1.99529e-15 (rank : 328)
Query Neighborhood Hits	1275	Target Neighborhood Hits	967	Shared Neighborhood Hits	781
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

DCAK1_MOUSE
NC score	0.887908 (rank : 326)	θ value	1.133e-10 (rank : 572)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	824
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

TTK_HUMAN
NC score	0.887897 (rank : 327)	θ value	4.76016e-09 (rank : 654)
Query Neighborhood Hits	1275	Target Neighborhood Hits	816	Shared Neighborhood Hits	773
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TBK1_MOUSE
NC score	0.887820 (rank : 328)	θ value	6.21693e-09 (rank : 657)
Query Neighborhood Hits	1275	Target Neighborhood Hits	893	Shared Neighborhood Hits	801
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

E2AK3_HUMAN
NC score	0.887810 (rank : 329)	θ value	5.26297e-08 (rank : 681)
Query Neighborhood Hits	1275	Target Neighborhood Hits	859	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

TSSK3_HUMAN
NC score	0.887769 (rank : 330)	θ value	5.8054e-15 (rank : 360)
Query Neighborhood Hits	1275	Target Neighborhood Hits	806	Shared Neighborhood Hits	791
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

ST32B_MOUSE
NC score	0.886875 (rank : 331)	θ value	4.02038e-16 (rank : 286)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	814
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

KS6A2_MOUSE
NC score	0.886035 (rank : 332)	θ value	4.29542e-18 (rank : 205)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

TSSK1_HUMAN
NC score	0.886017 (rank : 333)	θ value	2.35696e-16 (rank : 273)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	806
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

E2AK1_HUMAN
NC score	0.885946 (rank : 334)	θ value	3.08544e-08 (rank : 676)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	810
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

E2AK3_MOUSE
NC score	0.885804 (rank : 335)	θ value	5.26297e-08 (rank : 682)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	822
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

KS6A2_HUMAN
NC score	0.885786 (rank : 336)	θ value	2.5182e-18 (rank : 195)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	832
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PRKY_HUMAN
NC score	0.885430 (rank : 337)	θ value	2.52405e-10 (rank : 598)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	831
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

ST32C_HUMAN
NC score	0.885309 (rank : 338)	θ value	1.16975e-15 (rank : 316)
Query Neighborhood Hits	1275	Target Neighborhood Hits	832	Shared Neighborhood Hits	815
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

KS6A1_HUMAN
NC score	0.884813 (rank : 339)	θ value	2.7842e-17 (rank : 235)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	830
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PMYT1_HUMAN
NC score	0.884713 (rank : 340)	θ value	1.63604e-09 (rank : 631)
Query Neighborhood Hits	1275	Target Neighborhood Hits	814	Shared Neighborhood Hits	796
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

IRAK4_MOUSE
NC score	0.884697 (rank : 341)	θ value	2.88119e-14 (rank : 386)
Query Neighborhood Hits	1275	Target Neighborhood Hits	820	Shared Neighborhood Hits	803
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ST32B_HUMAN
NC score	0.884580 (rank : 342)	θ value	5.8054e-15 (rank : 359)
Query Neighborhood Hits	1275	Target Neighborhood Hits	830	Shared Neighborhood Hits	816
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

TAOK3_MOUSE
NC score	0.884106 (rank : 343)	θ value	7.0802e-21 (rank : 134)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1458	Shared Neighborhood Hits	876
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TTK_MOUSE
NC score	0.883666 (rank : 344)	θ value	3.41135e-07 (rank : 716)
Query Neighborhood Hits	1275	Target Neighborhood Hits	803	Shared Neighborhood Hits	764
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

KS6B1_MOUSE
NC score	0.883487 (rank : 345)	θ value	2.35696e-16 (rank : 272)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	823
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.883448 (rank : 346)	θ value	2.35696e-16 (rank : 271)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	823
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

DCAK2_MOUSE
NC score	0.883437 (rank : 347)	θ value	7.09661e-13 (rank : 464)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	822
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

TNIK_HUMAN
NC score	0.883189 (rank : 348)	θ value	4.44505e-15 (rank : 350)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1570	Shared Neighborhood Hits	908
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

KS6A6_HUMAN
NC score	0.883137 (rank : 349)	θ value	6.20254e-17 (rank : 245)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	830
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

IRAK4_HUMAN
NC score	0.883090 (rank : 350)	θ value	3.40345e-15 (rank : 339)
Query Neighborhood Hits	1275	Target Neighborhood Hits	816	Shared Neighborhood Hits	803
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

DCAK2_HUMAN
NC score	0.882034 (rank : 351)	θ value	7.09661e-13 (rank : 463)
Query Neighborhood Hits	1275	Target Neighborhood Hits	862	Shared Neighborhood Hits	823
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KS6A3_MOUSE
NC score	0.882012 (rank : 352)	θ value	5.25075e-16 (rank : 296)
Query Neighborhood Hits	1275	Target Neighborhood Hits	860	Shared Neighborhood Hits	832
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.881995 (rank : 353)	θ value	5.25075e-16 (rank : 295)
Query Neighborhood Hits	1275	Target Neighborhood Hits	859	Shared Neighborhood Hits	832
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

M3K13_HUMAN
NC score	0.881430 (rank : 354)	θ value	1.99529e-15 (rank : 326)
Query Neighborhood Hits	1275	Target Neighborhood Hits	911	Shared Neighborhood Hits	833
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

TSSK2_MOUSE
NC score	0.880936 (rank : 355)	θ value	2.20605e-14 (rank : 381)
Query Neighborhood Hits	1275	Target Neighborhood Hits	819	Shared Neighborhood Hits	805
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

UHMK1_MOUSE
NC score	0.880935 (rank : 356)	θ value	1.29631e-06 (rank : 729)
Query Neighborhood Hits	1275	Target Neighborhood Hits	809	Shared Neighborhood Hits	768
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

KAPCG_HUMAN
NC score	0.880785 (rank : 357)	θ value	1.99529e-15 (rank : 324)
Query Neighborhood Hits	1275	Target Neighborhood Hits	845	Shared Neighborhood Hits	827
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

TESK1_MOUSE
NC score	0.880536 (rank : 358)	θ value	5.43371e-13 (rank : 461)
Query Neighborhood Hits	1275	Target Neighborhood Hits	862	Shared Neighborhood Hits	815
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

UHMK1_HUMAN
NC score	0.880484 (rank : 359)	θ value	7.59969e-07 (rank : 723)
Query Neighborhood Hits	1275	Target Neighborhood Hits	808	Shared Neighborhood Hits	768
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

KS6A1_MOUSE
NC score	0.880360 (rank : 360)	θ value	2.13179e-17 (rank : 227)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	829
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

TESK1_HUMAN
NC score	0.880127 (rank : 361)	θ value	7.84624e-12 (rank : 520)
Query Neighborhood Hits	1275	Target Neighborhood Hits	864	Shared Neighborhood Hits	818
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TAOK3_HUMAN
NC score	0.879761 (rank : 362)	θ value	3.17815e-21 (rank : 130)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1494	Shared Neighborhood Hits	877
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

SLK_MOUSE
NC score	0.879512 (rank : 363)	θ value	4.74913e-17 (rank : 241)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1798	Shared Neighborhood Hits	911
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

NRK_MOUSE
NC score	0.878945 (rank : 364)	θ value	5.62301e-10 (rank : 613)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	840
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NRK_HUMAN
NC score	0.878587 (rank : 365)	θ value	1.63604e-09 (rank : 630)
Query Neighborhood Hits	1275	Target Neighborhood Hits	931	Shared Neighborhood Hits	837
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

M3K8_MOUSE
NC score	0.878445 (rank : 366)	θ value	7.59969e-07 (rank : 722)
Query Neighborhood Hits	1275	Target Neighborhood Hits	815	Shared Neighborhood Hits	793
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

M3K8_HUMAN
NC score	0.877363 (rank : 367)	θ value	3.19293e-05 (rank : 771)
Query Neighborhood Hits	1275	Target Neighborhood Hits	807	Shared Neighborhood Hits	792
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

SLK_HUMAN
NC score	0.877175 (rank : 368)	θ value	8.65492e-19 (rank : 180)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1775	Shared Neighborhood Hits	910
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

ERN1_HUMAN
NC score	0.876843 (rank : 369)	θ value	7.59969e-07 (rank : 721)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	805
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KS6B2_HUMAN
NC score	0.876629 (rank : 370)	θ value	2.20605e-14 (rank : 377)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	832
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

PRKX_MOUSE
NC score	0.875637 (rank : 371)	θ value	4.59992e-12 (rank : 504)
Query Neighborhood Hits	1275	Target Neighborhood Hits	846	Shared Neighborhood Hits	832
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

KAPCA_HUMAN
NC score	0.875636 (rank : 372)	θ value	5.25075e-16 (rank : 293)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

TESK2_HUMAN
NC score	0.875562 (rank : 373)	θ value	1.133e-10 (rank : 577)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	806
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

PRKX_HUMAN
NC score	0.875221 (rank : 374)	θ value	3.89403e-11 (rank : 556)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	831
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

M3K7_MOUSE
NC score	0.874931 (rank : 375)	θ value	4.30538e-10 (rank : 605)
Query Neighborhood Hits	1275	Target Neighborhood Hits	892	Shared Neighborhood Hits	821
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

KAPCA_MOUSE
NC score	0.874898 (rank : 376)	θ value	6.85773e-16 (rank : 303)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	824
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

M3K7_HUMAN
NC score	0.874823 (rank : 377)	θ value	4.30538e-10 (rank : 604)
Query Neighborhood Hits	1275	Target Neighborhood Hits	892	Shared Neighborhood Hits	820
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

KS6A5_HUMAN
NC score	0.874744 (rank : 378)	θ value	8.10077e-17 (rank : 250)
Query Neighborhood Hits	1275	Target Neighborhood Hits	855	Shared Neighborhood Hits	826
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

TESK2_MOUSE
NC score	0.874409 (rank : 379)	θ value	4.30538e-10 (rank : 608)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	805
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

MAPK2_HUMAN
NC score	0.874231 (rank : 380)	θ value	2.69671e-12 (rank : 486)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	809
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

PIM1_HUMAN
NC score	0.874152 (rank : 381)	θ value	1.74796e-11 (rank : 537)
Query Neighborhood Hits	1275	Target Neighborhood Hits	797	Shared Neighborhood Hits	783
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

CLK1_MOUSE
NC score	0.873967 (rank : 382)	θ value	3.07829e-16 (rank : 274)
Query Neighborhood Hits	1275	Target Neighborhood Hits	760	Shared Neighborhood Hits	743
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

GRK6_HUMAN
NC score	0.873878 (rank : 383)	θ value	5.25075e-16 (rank : 291)
Query Neighborhood Hits	1275	Target Neighborhood Hits	823	Shared Neighborhood Hits	809
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KS6B2_MOUSE
NC score	0.873854 (rank : 384)	θ value	9.26847e-13 (rank : 470)
Query Neighborhood Hits	1275	Target Neighborhood Hits	871	Shared Neighborhood Hits	834
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PIM2_MOUSE
NC score	0.873700 (rank : 385)	θ value	5.08577e-11 (rank : 561)
Query Neighborhood Hits	1275	Target Neighborhood Hits	809	Shared Neighborhood Hits	793
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

MAPK2_MOUSE
NC score	0.873508 (rank : 386)	θ value	3.52202e-12 (rank : 498)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	803
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

M4K4_HUMAN
NC score	0.873395 (rank : 387)	θ value	5.25075e-16 (rank : 297)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1589	Shared Neighborhood Hits	895
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

GRK6_MOUSE
NC score	0.872954 (rank : 388)	θ value	5.25075e-16 (rank : 292)
Query Neighborhood Hits	1275	Target Neighborhood Hits	820	Shared Neighborhood Hits	810
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

M3K12_HUMAN
NC score	0.872913 (rank : 389)	θ value	3.89403e-11 (rank : 553)
Query Neighborhood Hits	1275	Target Neighborhood Hits	940	Shared Neighborhood Hits	840
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.872756 (rank : 390)	θ value	3.89403e-11 (rank : 554)
Query Neighborhood Hits	1275	Target Neighborhood Hits	957	Shared Neighborhood Hits	837
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

KAPCB_HUMAN
NC score	0.872432 (rank : 391)	θ value	2.43908e-13 (rank : 440)
Query Neighborhood Hits	1275	Target Neighborhood Hits	837	Shared Neighborhood Hits	823
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

RIPK5_HUMAN
NC score	0.872377 (rank : 392)	θ value	1.17247e-07 (rank : 695)
Query Neighborhood Hits	1275	Target Neighborhood Hits	864	Shared Neighborhood Hits	827
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

PIM2_HUMAN
NC score	0.872128 (rank : 393)	θ value	2.52405e-10 (rank : 597)
Query Neighborhood Hits	1275	Target Neighborhood Hits	808	Shared Neighborhood Hits	799
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

KPCT_HUMAN
NC score	0.871954 (rank : 394)	θ value	3.76295e-14 (rank : 393)
Query Neighborhood Hits	1275	Target Neighborhood Hits	897	Shared Neighborhood Hits	824
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KAPCB_MOUSE
NC score	0.871900 (rank : 395)	θ value	1.86753e-13 (rank : 434)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	823
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

CLK1_HUMAN
NC score	0.871601 (rank : 396)	θ value	4.02038e-16 (rank : 279)
Query Neighborhood Hits	1275	Target Neighborhood Hits	756	Shared Neighborhood Hits	735
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

RIPK5_MOUSE
NC score	0.871599 (rank : 397)	θ value	1.17247e-07 (rank : 696)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	828
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

F5006_MOUSE
NC score	0.871536 (rank : 398)	θ value	1.33837e-11 (rank : 527)
Query Neighborhood Hits	1275	Target Neighborhood Hits	793	Shared Neighborhood Hits	789
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

GRK7_HUMAN
NC score	0.871170 (rank : 399)	θ value	4.59992e-12 (rank : 499)
Query Neighborhood Hits	1275	Target Neighborhood Hits	820	Shared Neighborhood Hits	813
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

ERN1_MOUSE
NC score	0.871128 (rank : 400)	θ value	6.43352e-06 (rank : 747)
Query Neighborhood Hits	1275	Target Neighborhood Hits	823	Shared Neighborhood Hits	801
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

GRK5_MOUSE
NC score	0.871009 (rank : 401)	θ value	5.8054e-15 (rank : 352)
Query Neighborhood Hits	1275	Target Neighborhood Hits	823	Shared Neighborhood Hits	804
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

E2AK4_HUMAN
NC score	0.870824 (rank : 402)	θ value	5.26297e-08 (rank : 683)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1012	Shared Neighborhood Hits	845
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

GRK5_HUMAN
NC score	0.870706 (rank : 403)	θ value	5.8054e-15 (rank : 351)
Query Neighborhood Hits	1275	Target Neighborhood Hits	819	Shared Neighborhood Hits	804
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

PIM1_MOUSE
NC score	0.870552 (rank : 404)	θ value	1.33837e-11 (rank : 532)
Query Neighborhood Hits	1275	Target Neighborhood Hits	787	Shared Neighborhood Hits	773
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

SGK1_HUMAN
NC score	0.870372 (rank : 405)	θ value	6.64225e-11 (rank : 564)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	827
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

MKNK2_HUMAN
NC score	0.870323 (rank : 406)	θ value	2.69671e-12 (rank : 487)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	806
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

CLK4_HUMAN
NC score	0.869981 (rank : 407)	θ value	1.16975e-15 (rank : 312)
Query Neighborhood Hits	1275	Target Neighborhood Hits	759	Shared Neighborhood Hits	747
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

SGK2_MOUSE
NC score	0.869966 (rank : 408)	θ value	1.42992e-13 (rank : 431)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	820
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

KS6A4_MOUSE
NC score	0.869832 (rank : 409)	θ value	4.02038e-16 (rank : 284)
Query Neighborhood Hits	1275	Target Neighborhood Hits	866	Shared Neighborhood Hits	835
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

SGK1_MOUSE
NC score	0.869733 (rank : 410)	θ value	8.67504e-11 (rank : 571)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	827
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

KPCT_MOUSE
NC score	0.869713 (rank : 411)	θ value	1.09485e-13 (rank : 419)
Query Neighborhood Hits	1275	Target Neighborhood Hits	895	Shared Neighborhood Hits	821
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MAPK3_MOUSE
NC score	0.869687 (rank : 412)	θ value	1.25267e-09 (rank : 626)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	794
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

AKT3_HUMAN
NC score	0.869512 (rank : 413)	θ value	8.10077e-17 (rank : 247)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	820
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.869468 (rank : 414)	θ value	8.10077e-17 (rank : 248)
Query Neighborhood Hits	1275	Target Neighborhood Hits	872	Shared Neighborhood Hits	820
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

CLK4_MOUSE
NC score	0.869122 (rank : 415)	θ value	4.02038e-16 (rank : 280)
Query Neighborhood Hits	1275	Target Neighborhood Hits	759	Shared Neighborhood Hits	746
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

SGK2_HUMAN
NC score	0.869039 (rank : 416)	θ value	3.18553e-13 (rank : 447)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	824
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

RIPK1_HUMAN
NC score	0.868788 (rank : 417)	θ value	4.76016e-09 (rank : 651)
Query Neighborhood Hits	1275	Target Neighborhood Hits	891	Shared Neighborhood Hits	833
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

RK_MOUSE
NC score	0.868762 (rank : 418)	θ value	8.10077e-17 (rank : 251)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	813
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MKNK2_MOUSE
NC score	0.868760 (rank : 419)	θ value	9.26847e-13 (rank : 473)
Query Neighborhood Hits	1275	Target Neighborhood Hits	819	Shared Neighborhood Hits	804
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

M4K4_MOUSE
NC score	0.868303 (rank : 420)	θ value	1.42992e-13 (rank : 428)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1560	Shared Neighborhood Hits	900
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

KS6A4_HUMAN
NC score	0.868257 (rank : 421)	θ value	4.74913e-17 (rank : 238)
Query Neighborhood Hits	1275	Target Neighborhood Hits	868	Shared Neighborhood Hits	837
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

TAOK1_MOUSE
NC score	0.868206 (rank : 422)	θ value	1.42661e-21 (rank : 123)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1720	Shared Neighborhood Hits	901
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK1_HUMAN
NC score	0.867934 (rank : 423)	θ value	1.42661e-21 (rank : 122)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1734	Shared Neighborhood Hits	900
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

MAPK3_HUMAN
NC score	0.866824 (rank : 424)	θ value	9.59137e-10 (rank : 622)
Query Neighborhood Hits	1275	Target Neighborhood Hits	807	Shared Neighborhood Hits	785
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

RIPK1_MOUSE
NC score	0.866535 (rank : 425)	θ value	1.9326e-10 (rank : 588)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	830
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

AKT2_HUMAN
NC score	0.866472 (rank : 426)	θ value	1.99529e-15 (rank : 321)
Query Neighborhood Hits	1275	Target Neighborhood Hits	878	Shared Neighborhood Hits	818
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

ERN2_HUMAN
NC score	0.866458 (rank : 427)	θ value	1.43324e-05 (rank : 754)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	811
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

PKN2_HUMAN
NC score	0.866417 (rank : 428)	θ value	2.69671e-12 (rank : 492)
Query Neighborhood Hits	1275	Target Neighborhood Hits	892	Shared Neighborhood Hits	824
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
NC score	0.866378 (rank : 429)	θ value	4.59992e-12 (rank : 503)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	821
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

MOS_MOUSE
NC score	0.866155 (rank : 430)	θ value	4.92598e-06 (rank : 743)
Query Neighborhood Hits	1275	Target Neighborhood Hits	833	Shared Neighborhood Hits	818
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

PIM3_HUMAN
NC score	0.866081 (rank : 431)	θ value	1.9326e-10 (rank : 587)
Query Neighborhood Hits	1275	Target Neighborhood Hits	789	Shared Neighborhood Hits	777
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

AKT2_MOUSE
NC score	0.866071 (rank : 432)	θ value	8.95645e-16 (rank : 309)
Query Neighborhood Hits	1275	Target Neighborhood Hits	875	Shared Neighborhood Hits	818
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

E2AK4_MOUSE
NC score	0.865711 (rank : 433)	θ value	3.08544e-08 (rank : 677)
Query Neighborhood Hits	1275	Target Neighborhood Hits	984	Shared Neighborhood Hits	839
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

GRK4_HUMAN
NC score	0.865412 (rank : 434)	θ value	1.09485e-13 (rank : 416)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	804
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

SGK3_MOUSE
NC score	0.865042 (rank : 435)	θ value	1.47974e-10 (rank : 581)
Query Neighborhood Hits	1275	Target Neighborhood Hits	882	Shared Neighborhood Hits	819
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

KS6A5_MOUSE
NC score	0.864990 (rank : 436)	θ value	4.74913e-17 (rank : 239)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	826
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MASTL_HUMAN
NC score	0.864878 (rank : 437)	θ value	1.63604e-09 (rank : 629)
Query Neighborhood Hits	1275	Target Neighborhood Hits	894	Shared Neighborhood Hits	827
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

RK_HUMAN
NC score	0.864859 (rank : 438)	θ value	1.68911e-14 (rank : 373)
Query Neighborhood Hits	1275	Target Neighborhood Hits	835	Shared Neighborhood Hits	814
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

SGK3_HUMAN
NC score	0.864692 (rank : 439)	θ value	1.9326e-10 (rank : 590)
Query Neighborhood Hits	1275	Target Neighborhood Hits	877	Shared Neighborhood Hits	819
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

GAK_HUMAN
NC score	0.863900 (rank : 440)	θ value	1.02475e-11 (rank : 523)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1028	Shared Neighborhood Hits	830
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

RAF1_HUMAN
NC score	0.863814 (rank : 441)	θ value	7.84624e-12 (rank : 518)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	826
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

ERN2_MOUSE
NC score	0.863615 (rank : 442)	θ value	2.88788e-06 (rank : 737)
Query Neighborhood Hits	1275	Target Neighborhood Hits	825	Shared Neighborhood Hits	803
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

PKN1_MOUSE
NC score	0.863587 (rank : 443)	θ value	4.59992e-12 (rank : 502)
Query Neighborhood Hits	1275	Target Neighborhood Hits	888	Shared Neighborhood Hits	821
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

MOS_HUMAN
NC score	0.863576 (rank : 444)	θ value	7.1131e-05 (rank : 777)
Query Neighborhood Hits	1275	Target Neighborhood Hits	829	Shared Neighborhood Hits	817
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MASTL_MOUSE
NC score	0.863424 (rank : 445)	θ value	3.64472e-09 (rank : 637)
Query Neighborhood Hits	1275	Target Neighborhood Hits	862	Shared Neighborhood Hits	823
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

RAF1_MOUSE
NC score	0.863358 (rank : 446)	θ value	3.89403e-11 (rank : 557)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	830
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

GRK4_MOUSE
NC score	0.863220 (rank : 447)	θ value	1.99529e-15 (rank : 323)
Query Neighborhood Hits	1275	Target Neighborhood Hits	808	Shared Neighborhood Hits	797
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

PKN1_HUMAN
NC score	0.863102 (rank : 448)	θ value	2.28291e-11 (rank : 543)
Query Neighborhood Hits	1275	Target Neighborhood Hits	886	Shared Neighborhood Hits	829
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

MAST3_HUMAN
NC score	0.863048 (rank : 449)	θ value	2.20605e-14 (rank : 378)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1128	Shared Neighborhood Hits	902
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST2_MOUSE
NC score	0.862936 (rank : 450)	θ value	2.88119e-14 (rank : 388)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1110	Shared Neighborhood Hits	870
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MKNK1_MOUSE
NC score	0.862710 (rank : 451)	θ value	1.33837e-11 (rank : 529)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	794
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

BMP2K_MOUSE
NC score	0.862627 (rank : 452)	θ value	1.42992e-13 (rank : 424)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	783
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CLK2_HUMAN
NC score	0.862475 (rank : 453)	θ value	3.07829e-16 (rank : 275)
Query Neighborhood Hits	1275	Target Neighborhood Hits	752	Shared Neighborhood Hits	733
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

MAST2_HUMAN
NC score	0.862284 (rank : 454)	θ value	9.90251e-15 (rank : 367)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1189	Shared Neighborhood Hits	895
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PIM3_MOUSE
NC score	0.862227 (rank : 455)	θ value	7.34386e-10 (rank : 615)
Query Neighborhood Hits	1275	Target Neighborhood Hits	783	Shared Neighborhood Hits	771
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

F5006_HUMAN
NC score	0.861612 (rank : 456)	θ value	4.30538e-10 (rank : 602)
Query Neighborhood Hits	1275	Target Neighborhood Hits	794	Shared Neighborhood Hits	784
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

KGP2_HUMAN
NC score	0.861422 (rank : 457)	θ value	1.9326e-10 (rank : 586)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1023	Shared Neighborhood Hits	840
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

MLTK_MOUSE
NC score	0.860946 (rank : 458)	θ value	5.62301e-10 (rank : 612)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	812
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MLTK_HUMAN
NC score	0.860699 (rank : 459)	θ value	8.67504e-11 (rank : 569)
Query Neighborhood Hits	1275	Target Neighborhood Hits	911	Shared Neighborhood Hits	816
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

PKN3_HUMAN
NC score	0.860582 (rank : 460)	θ value	3.89403e-11 (rank : 555)
Query Neighborhood Hits	1275	Target Neighborhood Hits	893	Shared Neighborhood Hits	828
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

BRAF1_HUMAN
NC score	0.860576 (rank : 461)	θ value	4.76016e-09 (rank : 641)
Query Neighborhood Hits	1275	Target Neighborhood Hits	883	Shared Neighborhood Hits	821
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

KPCD_HUMAN
NC score	0.860502 (rank : 462)	θ value	3.52202e-12 (rank : 496)
Query Neighborhood Hits	1275	Target Neighborhood Hits	900	Shared Neighborhood Hits	820
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

GAK_MOUSE
NC score	0.860469 (rank : 463)	θ value	6.00763e-12 (rank : 510)
Query Neighborhood Hits	1275	Target Neighborhood Hits	964	Shared Neighborhood Hits	819
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

AKT1_MOUSE
NC score	0.860126 (rank : 464)	θ value	9.90251e-15 (rank : 362)
Query Neighborhood Hits	1275	Target Neighborhood Hits	878	Shared Neighborhood Hits	817
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT1_HUMAN
NC score	0.859626 (rank : 465)	θ value	1.42992e-13 (rank : 423)
Query Neighborhood Hits	1275	Target Neighborhood Hits	885	Shared Neighborhood Hits	818
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

KGP2_MOUSE
NC score	0.859612 (rank : 466)	θ value	5.62301e-10 (rank : 610)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1029	Shared Neighborhood Hits	840
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

PKN3_MOUSE
NC score	0.859563 (rank : 467)	θ value	1.58096e-12 (rank : 482)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	841
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

BMP2K_HUMAN
NC score	0.859538 (rank : 468)	θ value	5.08577e-11 (rank : 559)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	786
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

ARBK1_HUMAN
NC score	0.858173 (rank : 469)	θ value	2.43908e-13 (rank : 437)
Query Neighborhood Hits	1275	Target Neighborhood Hits	859	Shared Neighborhood Hits	814
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

STK10_HUMAN
NC score	0.857823 (rank : 470)	θ value	6.62687e-19 (rank : 176)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1921	Shared Neighborhood Hits	915
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CAMKV_MOUSE
NC score	0.857736 (rank : 471)	θ value	5.25075e-16 (rank : 288)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	785
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

WNK3_HUMAN
NC score	0.857301 (rank : 472)	θ value	6.64225e-11 (rank : 566)
Query Neighborhood Hits	1275	Target Neighborhood Hits	948	Shared Neighborhood Hits	784
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

KGP1A_HUMAN
NC score	0.857267 (rank : 473)	θ value	4.76016e-09 (rank : 643)
Query Neighborhood Hits	1275	Target Neighborhood Hits	901	Shared Neighborhood Hits	822
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

MAST1_HUMAN
NC score	0.857070 (rank : 474)	θ value	3.76295e-14 (rank : 395)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1146	Shared Neighborhood Hits	877
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

CLK3_HUMAN
NC score	0.856979 (rank : 475)	θ value	4.29542e-18 (rank : 203)
Query Neighborhood Hits	1275	Target Neighborhood Hits	748	Shared Neighborhood Hits	729
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

KGP1B_MOUSE
NC score	0.856821 (rank : 476)	θ value	4.76016e-09 (rank : 645)
Query Neighborhood Hits	1275	Target Neighborhood Hits	922	Shared Neighborhood Hits	826
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.856775 (rank : 477)	θ value	4.76016e-09 (rank : 644)
Query Neighborhood Hits	1275	Target Neighborhood Hits	921	Shared Neighborhood Hits	826
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

CLK3_MOUSE
NC score	0.856397 (rank : 478)	θ value	4.29542e-18 (rank : 204)
Query Neighborhood Hits	1275	Target Neighborhood Hits	761	Shared Neighborhood Hits	731
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

JAK2_HUMAN
NC score	0.856340 (rank : 479)	θ value	1.74391e-19 (rank : 163)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	817
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

WNK1_HUMAN
NC score	0.856136 (rank : 480)	θ value	7.84624e-12 (rank : 521)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1158	Shared Neighborhood Hits	849
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

MAST1_MOUSE
NC score	0.856060 (rank : 481)	θ value	3.76295e-14 (rank : 396)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1123	Shared Neighborhood Hits	865
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KPCI_MOUSE
NC score	0.855584 (rank : 482)	θ value	1.09485e-13 (rank : 418)
Query Neighborhood Hits	1275	Target Neighborhood Hits	888	Shared Neighborhood Hits	828
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

ARAF_HUMAN
NC score	0.855578 (rank : 483)	θ value	4.76016e-09 (rank : 640)
Query Neighborhood Hits	1275	Target Neighborhood Hits	924	Shared Neighborhood Hits	831
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

KPCI_HUMAN
NC score	0.855546 (rank : 484)	θ value	3.18553e-13 (rank : 445)
Query Neighborhood Hits	1275	Target Neighborhood Hits	885	Shared Neighborhood Hits	827
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCE_MOUSE
NC score	0.855435 (rank : 485)	θ value	6.41864e-14 (rank : 408)
Query Neighborhood Hits	1275	Target Neighborhood Hits	906	Shared Neighborhood Hits	817
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

ARAF_MOUSE
NC score	0.855431 (rank : 486)	θ value	6.87365e-08 (rank : 686)
Query Neighborhood Hits	1275	Target Neighborhood Hits	874	Shared Neighborhood Hits	826
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARBK1_MOUSE
NC score	0.855339 (rank : 487)	θ value	2.43908e-13 (rank : 438)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	814
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

KPCE_HUMAN
NC score	0.855203 (rank : 488)	θ value	9.90251e-15 (rank : 366)
Query Neighborhood Hits	1275	Target Neighborhood Hits	906	Shared Neighborhood Hits	818
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCD_MOUSE
NC score	0.854531 (rank : 489)	θ value	9.59137e-10 (rank : 621)
Query Neighborhood Hits	1275	Target Neighborhood Hits	888	Shared Neighborhood Hits	818
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

ARBK2_HUMAN
NC score	0.854381 (rank : 490)	θ value	5.43371e-13 (rank : 451)
Query Neighborhood Hits	1275	Target Neighborhood Hits	849	Shared Neighborhood Hits	810
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

WNK1_MOUSE
NC score	0.854338 (rank : 491)	θ value	7.84624e-12 (rank : 522)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1179	Shared Neighborhood Hits	851
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

KPCL_MOUSE
NC score	0.853689 (rank : 492)	θ value	1.80466e-16 (rank : 264)
Query Neighborhood Hits	1275	Target Neighborhood Hits	891	Shared Neighborhood Hits	815
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

JAK2_MOUSE
NC score	0.853321 (rank : 493)	θ value	8.65492e-19 (rank : 177)
Query Neighborhood Hits	1275	Target Neighborhood Hits	839	Shared Neighborhood Hits	813
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

WNK4_MOUSE
NC score	0.852907 (rank : 494)	θ value	2.98157e-11 (rank : 549)
Query Neighborhood Hits	1275	Target Neighborhood Hits	961	Shared Neighborhood Hits	816
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

CAMKV_HUMAN
NC score	0.852866 (rank : 495)	θ value	4.29542e-18 (rank : 202)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1084	Shared Neighborhood Hits	822
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CLK2_MOUSE
NC score	0.852853 (rank : 496)	θ value	2.35696e-16 (rank : 268)
Query Neighborhood Hits	1275	Target Neighborhood Hits	743	Shared Neighborhood Hits	727
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

LIMK1_HUMAN
NC score	0.852360 (rank : 497)	θ value	2.13179e-17 (rank : 228)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1005	Shared Neighborhood Hits	818
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

M3K11_HUMAN
NC score	0.852265 (rank : 498)	θ value	6.21693e-09 (rank : 655)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1136	Shared Neighborhood Hits	868
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

LIMK1_MOUSE
NC score	0.852234 (rank : 499)	θ value	6.20254e-17 (rank : 246)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1008	Shared Neighborhood Hits	816
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

M3K9_HUMAN
NC score	0.852220 (rank : 500)	θ value	1.38499e-08 (rank : 662)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1123	Shared Neighborhood Hits	848
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MAST4_HUMAN
NC score	0.852106 (rank : 501)	θ value	8.38298e-14 (rank : 411)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1804	Shared Neighborhood Hits	983
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

AAK1_HUMAN
NC score	0.851196 (rank : 502)	θ value	1.47974e-10 (rank : 578)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1077	Shared Neighborhood Hits	868
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

JAK3_MOUSE
NC score	0.850427 (rank : 503)	θ value	2.20605e-14 (rank : 375)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	802
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

WNK4_HUMAN
NC score	0.850410 (rank : 504)	θ value	3.89403e-11 (rank : 558)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1043	Shared Neighborhood Hits	833
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

KPCL_HUMAN
NC score	0.849943 (rank : 505)	θ value	5.25075e-16 (rank : 294)
Query Neighborhood Hits	1275	Target Neighborhood Hits	887	Shared Neighborhood Hits	815
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

AAK1_MOUSE
NC score	0.849487 (rank : 506)	θ value	3.52202e-12 (rank : 495)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1051	Shared Neighborhood Hits	855
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

LIMK2_HUMAN
NC score	0.849129 (rank : 507)	θ value	3.18553e-13 (rank : 446)
Query Neighborhood Hits	1275	Target Neighborhood Hits	986	Shared Neighborhood Hits	809
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

KPCZ_HUMAN
NC score	0.849053 (rank : 508)	θ value	1.74796e-11 (rank : 534)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	823
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
NC score	0.849051 (rank : 509)	θ value	4.59992e-12 (rank : 500)
Query Neighborhood Hits	1275	Target Neighborhood Hits	882	Shared Neighborhood Hits	824
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

RIPK3_HUMAN
NC score	0.848983 (rank : 510)	θ value	1.25267e-09 (rank : 627)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	800
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

WNK2_HUMAN
NC score	0.848278 (rank : 511)	θ value	1.47974e-10 (rank : 583)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1407	Shared Neighborhood Hits	912
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

M3K10_HUMAN
NC score	0.848099 (rank : 512)	θ value	3.08544e-08 (rank : 678)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1071	Shared Neighborhood Hits	835
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

CSKP_MOUSE
NC score	0.847958 (rank : 513)	θ value	8.93572e-24 (rank : 100)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1027	Shared Neighborhood Hits	806
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

RIPK3_MOUSE
NC score	0.846471 (rank : 514)	θ value	1.29631e-06 (rank : 728)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	805
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

LIMK2_MOUSE
NC score	0.846302 (rank : 515)	θ value	2.88119e-14 (rank : 387)
Query Neighborhood Hits	1275	Target Neighborhood Hits	998	Shared Neighborhood Hits	808
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

CSKP_HUMAN
NC score	0.845396 (rank : 516)	θ value	1.5242e-23 (rank : 102)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1022	Shared Neighborhood Hits	805
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

M3KL4_HUMAN
NC score	0.843465 (rank : 517)	θ value	5.62301e-10 (rank : 611)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1087	Shared Neighborhood Hits	837
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

JAK3_HUMAN
NC score	0.842574 (rank : 518)	θ value	6.41864e-14 (rank : 405)
Query Neighborhood Hits	1275	Target Neighborhood Hits	827	Shared Neighborhood Hits	811
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

TYK2_HUMAN
NC score	0.841807 (rank : 519)	θ value	1.38178e-16 (rank : 261)
Query Neighborhood Hits	1275	Target Neighborhood Hits	841	Shared Neighborhood Hits	818
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

MAPK5_MOUSE
NC score	0.840160 (rank : 520)	θ value	7.84624e-12 (rank : 516)
Query Neighborhood Hits	1275	Target Neighborhood Hits	799	Shared Neighborhood Hits	781
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

TYK2_MOUSE
NC score	0.839400 (rank : 521)	θ value	2.60593e-15 (rank : 337)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	817
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

KPCA_MOUSE
NC score	0.838739 (rank : 522)	θ value	1.29331e-14 (rank : 369)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1067	Shared Neighborhood Hits	817
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

JAK1_HUMAN
NC score	0.838661 (rank : 523)	θ value	5.8054e-15 (rank : 353)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	820
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

MAPK5_HUMAN
NC score	0.838083 (rank : 524)	θ value	4.59992e-12 (rank : 501)
Query Neighborhood Hits	1275	Target Neighborhood Hits	795	Shared Neighborhood Hits	776
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

KPCA_HUMAN
NC score	0.835965 (rank : 525)	θ value	6.41864e-14 (rank : 407)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1070	Shared Neighborhood Hits	820
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

STK10_MOUSE
NC score	0.835446 (rank : 526)	θ value	4.58923e-20 (rank : 149)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2132	Shared Neighborhood Hits	934
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

JAK1_MOUSE
NC score	0.835002 (rank : 527)	θ value	1.09485e-13 (rank : 417)
Query Neighborhood Hits	1275	Target Neighborhood Hits	854	Shared Neighborhood Hits	816
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

ST38L_HUMAN
NC score	0.833492 (rank : 528)	θ value	2.43908e-13 (rank : 442)
Query Neighborhood Hits	1275	Target Neighborhood Hits	824	Shared Neighborhood Hits	789
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK38_MOUSE
NC score	0.833409 (rank : 529)	θ value	4.59992e-12 (rank : 507)
Query Neighborhood Hits	1275	Target Neighborhood Hits	838	Shared Neighborhood Hits	793
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

KSR2_HUMAN
NC score	0.833209 (rank : 530)	θ value	1.99992e-07 (rank : 705)
Query Neighborhood Hits	1275	Target Neighborhood Hits	920	Shared Neighborhood Hits	844
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

DMPK_MOUSE
NC score	0.833082 (rank : 531)	θ value	2.20605e-14 (rank : 374)
Query Neighborhood Hits	1275	Target Neighborhood Hits	908	Shared Neighborhood Hits	815
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_HUMAN
NC score	0.832935 (rank : 532)	θ value	9.90251e-15 (rank : 365)
Query Neighborhood Hits	1275	Target Neighborhood Hits	944	Shared Neighborhood Hits	818
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

STK38_HUMAN
NC score	0.832913 (rank : 533)	θ value	4.59992e-12 (rank : 506)
Query Neighborhood Hits	1275	Target Neighborhood Hits	840	Shared Neighborhood Hits	793
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

KPCG_MOUSE
NC score	0.826610 (rank : 534)	θ value	2.43908e-13 (rank : 441)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1123	Shared Neighborhood Hits	817
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCB_MOUSE
NC score	0.826282 (rank : 535)	θ value	6.00763e-12 (rank : 512)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1117	Shared Neighborhood Hits	820
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCG_HUMAN
NC score	0.826103 (rank : 536)	θ value	3.18553e-13 (rank : 444)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1126	Shared Neighborhood Hits	817
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PTK6_HUMAN
NC score	0.825980 (rank : 537)	θ value	4.91457e-14 (rank : 400)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1020	Shared Neighborhood Hits	821
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

KPCB_HUMAN
NC score	0.825576 (rank : 538)	θ value	6.00763e-12 (rank : 511)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1121	Shared Neighborhood Hits	821
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

SPEG_HUMAN
NC score	0.824536 (rank : 539)	θ value	1.38178e-16 (rank : 259)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1762	Shared Neighborhood Hits	967
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

WEE1_MOUSE
NC score	0.824391 (rank : 540)	θ value	0.00509761 (rank : 831)
Query Neighborhood Hits	1275	Target Neighborhood Hits	794	Shared Neighborhood Hits	752
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

FES_MOUSE
NC score	0.823437 (rank : 541)	θ value	1.52774e-15 (rank : 317)
Query Neighborhood Hits	1275	Target Neighborhood Hits	980	Shared Neighborhood Hits	820
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_HUMAN
NC score	0.823359 (rank : 542)	θ value	5.25075e-16 (rank : 290)
Query Neighborhood Hits	1275	Target Neighborhood Hits	978	Shared Neighborhood Hits	812
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

ST38L_MOUSE
NC score	0.822676 (rank : 543)	θ value	2.69671e-12 (rank : 494)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	784
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

LATS1_HUMAN
NC score	0.822187 (rank : 544)	θ value	9.26847e-13 (rank : 471)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1057	Shared Neighborhood Hits	879
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

MYLK_MOUSE
NC score	0.822019 (rank : 545)	θ value	1.38178e-16 (rank : 256)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1489	Shared Neighborhood Hits	883
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_HUMAN
NC score	0.821584 (rank : 546)	θ value	3.40345e-15 (rank : 344)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1328	Shared Neighborhood Hits	850
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

LATS1_MOUSE
NC score	0.821408 (rank : 547)	θ value	2.0648e-12 (rank : 483)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1027	Shared Neighborhood Hits	869
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

PTK6_MOUSE
NC score	0.821129 (rank : 548)	θ value	1.52774e-15 (rank : 320)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1026	Shared Neighborhood Hits	822
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

LATS2_HUMAN
NC score	0.817250 (rank : 549)	θ value	3.89403e-11 (rank : 552)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

SPEG_MOUSE
NC score	0.815611 (rank : 550)	θ value	9.90251e-15 (rank : 368)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1959	Shared Neighborhood Hits	996
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

LATS2_MOUSE
NC score	0.815548 (rank : 551)	θ value	8.67504e-11 (rank : 568)
Query Neighborhood Hits	1275	Target Neighborhood Hits	879	Shared Neighborhood Hits	816
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

AL2S2_HUMAN
NC score	0.815159 (rank : 552)	θ value	0.000121331 (rank : 782)
Query Neighborhood Hits	1275	Target Neighborhood Hits	727	Shared Neighborhood Hits	713
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

WEE1_HUMAN
NC score	0.814704 (rank : 553)	θ value	0.00102713 (rank : 812)
Query Neighborhood Hits	1275	Target Neighborhood Hits	777	Shared Neighborhood Hits	733
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

DAPK1_HUMAN
NC score	0.810856 (rank : 554)	θ value	8.38298e-14 (rank : 409)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1130	Shared Neighborhood Hits	828
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

CSK_MOUSE
NC score	0.809720 (rank : 555)	θ value	5.25075e-16 (rank : 289)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	822
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

KSR1_MOUSE
NC score	0.807548 (rank : 556)	θ value	2.44474e-05 (rank : 763)
Query Neighborhood Hits	1275	Target Neighborhood Hits	870	Shared Neighborhood Hits	807
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

DAPK1_MOUSE
NC score	0.806859 (rank : 557)	θ value	6.41864e-14 (rank : 402)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1138	Shared Neighborhood Hits	828
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

TEC_MOUSE
NC score	0.806069 (rank : 558)	θ value	1.47631e-18 (rank : 190)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1006	Shared Neighborhood Hits	813
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MRCKG_HUMAN
NC score	0.805761 (rank : 559)	θ value	5.8054e-15 (rank : 356)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1519	Shared Neighborhood Hits	877
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
NC score	0.803364 (rank : 560)	θ value	1.09485e-13 (rank : 420)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1466	Shared Neighborhood Hits	860
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MATK_MOUSE
NC score	0.802947 (rank : 561)	θ value	8.38298e-14 (rank : 412)
Query Neighborhood Hits	1275	Target Neighborhood Hits	952	Shared Neighborhood Hits	817
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

KSR1_HUMAN
NC score	0.802944 (rank : 562)	θ value	0.000121331 (rank : 785)
Query Neighborhood Hits	1275	Target Neighborhood Hits	867	Shared Neighborhood Hits	797
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

FAK1_MOUSE
NC score	0.802512 (rank : 563)	θ value	9.59137e-10 (rank : 618)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	810
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

LYN_MOUSE
NC score	0.802266 (rank : 564)	θ value	1.2105e-12 (rank : 479)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1023	Shared Neighborhood Hits	831
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

FAK1_HUMAN
NC score	0.802031 (rank : 565)	θ value	9.59137e-10 (rank : 617)
Query Neighborhood Hits	1275	Target Neighborhood Hits	850	Shared Neighborhood Hits	814
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

CSK_HUMAN
NC score	0.801807 (rank : 566)	θ value	1.16975e-15 (rank : 313)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	821
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

LYN_HUMAN
NC score	0.801563 (rank : 567)	θ value	5.43371e-13 (rank : 456)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1022	Shared Neighborhood Hits	832
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

KSYK_HUMAN
NC score	0.801552 (rank : 568)	θ value	2.98157e-11 (rank : 548)
Query Neighborhood Hits	1275	Target Neighborhood Hits	901	Shared Neighborhood Hits	803
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TXK_HUMAN
NC score	0.801503 (rank : 569)	θ value	2.20605e-14 (rank : 382)
Query Neighborhood Hits	1275	Target Neighborhood Hits	971	Shared Neighborhood Hits	809
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

KSYK_MOUSE
NC score	0.801401 (rank : 570)	θ value	2.28291e-11 (rank : 540)
Query Neighborhood Hits	1275	Target Neighborhood Hits	944	Shared Neighborhood Hits	810
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

SRMS_MOUSE
NC score	0.801348 (rank : 571)	θ value	2.0648e-12 (rank : 484)
Query Neighborhood Hits	1275	Target Neighborhood Hits	964	Shared Neighborhood Hits	823
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ABL1_MOUSE
NC score	0.801345 (rank : 572)	θ value	4.44505e-15 (rank : 347)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1178	Shared Neighborhood Hits	882
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

RIPK2_MOUSE
NC score	0.801163 (rank : 573)	θ value	8.97725e-08 (rank : 691)
Query Neighborhood Hits	1275	Target Neighborhood Hits	776	Shared Neighborhood Hits	748
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

FER_HUMAN
NC score	0.801045 (rank : 574)	θ value	3.40345e-15 (rank : 338)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1278	Shared Neighborhood Hits	829
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

TEC_HUMAN
NC score	0.801035 (rank : 575)	θ value	9.56915e-18 (rank : 219)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1006	Shared Neighborhood Hits	813
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZAP70_HUMAN
NC score	0.800757 (rank : 576)	θ value	2.52405e-10 (rank : 599)
Query Neighborhood Hits	1275	Target Neighborhood Hits	893	Shared Neighborhood Hits	810
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

AL2S2_MOUSE
NC score	0.800415 (rank : 577)	θ value	0.000461057 (rank : 798)
Query Neighborhood Hits	1275	Target Neighborhood Hits	709	Shared Neighborhood Hits	693
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

ZAP70_MOUSE
NC score	0.799512 (rank : 578)	θ value	7.34386e-10 (rank : 616)
Query Neighborhood Hits	1275	Target Neighborhood Hits	905	Shared Neighborhood Hits	813
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ABL1_HUMAN
NC score	0.799308 (rank : 579)	θ value	2.60593e-15 (rank : 331)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1220	Shared Neighborhood Hits	866
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FRK_HUMAN
NC score	0.799191 (rank : 580)	θ value	3.89403e-11 (rank : 550)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1058	Shared Neighborhood Hits	826
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

MATK_HUMAN
NC score	0.797735 (rank : 581)	θ value	9.26847e-13 (rank : 472)
Query Neighborhood Hits	1275	Target Neighborhood Hits	954	Shared Neighborhood Hits	816
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ITK_MOUSE
NC score	0.796913 (rank : 582)	θ value	3.89403e-11 (rank : 551)
Query Neighborhood Hits	1275	Target Neighborhood Hits	985	Shared Neighborhood Hits	817
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.796508 (rank : 583)	θ value	2.98157e-11 (rank : 547)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1016	Shared Neighborhood Hits	819
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

TRIO_HUMAN
NC score	0.795946 (rank : 584)	θ value	1.99992e-07 (rank : 706)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1580	Shared Neighborhood Hits	871
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

LCK_MOUSE
NC score	0.795938 (rank : 585)	θ value	3.76295e-14 (rank : 394)
Query Neighborhood Hits	1275	Target Neighborhood Hits	981	Shared Neighborhood Hits	818
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MYO3A_MOUSE
NC score	0.794487 (rank : 586)	θ value	9.56915e-18 (rank : 216)
Query Neighborhood Hits	1275	Target Neighborhood Hits	902	Shared Neighborhood Hits	821
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

BTK_HUMAN
NC score	0.794356 (rank : 587)	θ value	9.90251e-15 (rank : 363)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1026	Shared Neighborhood Hits	815
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.794279 (rank : 588)	θ value	4.44505e-15 (rank : 348)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1017	Shared Neighborhood Hits	817
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ABL2_HUMAN
NC score	0.794038 (rank : 589)	θ value	2.88119e-14 (rank : 383)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1045	Shared Neighborhood Hits	823
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

WEE1B_HUMAN
NC score	0.793970 (rank : 590)	θ value	3.19293e-05 (rank : 772)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	744
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

SRMS_HUMAN
NC score	0.793893 (rank : 591)	θ value	2.28291e-11 (rank : 544)
Query Neighborhood Hits	1275	Target Neighborhood Hits	946	Shared Neighborhood Hits	822
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

RIPK2_HUMAN
NC score	0.793711 (rank : 592)	θ value	3.77169e-06 (rank : 739)
Query Neighborhood Hits	1275	Target Neighborhood Hits	774	Shared Neighborhood Hits	747
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

BLK_HUMAN
NC score	0.792964 (rank : 593)	θ value	3.76295e-14 (rank : 391)
Query Neighborhood Hits	1275	Target Neighborhood Hits	994	Shared Neighborhood Hits	824
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LCK_HUMAN
NC score	0.792352 (rank : 594)	θ value	1.68911e-14 (rank : 371)
Query Neighborhood Hits	1275	Target Neighborhood Hits	987	Shared Neighborhood Hits	819
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

IRAK1_HUMAN
NC score	0.791946 (rank : 595)	θ value	1.09739e-05 (rank : 752)
Query Neighborhood Hits	1275	Target Neighborhood Hits	820	Shared Neighborhood Hits	761
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

FYN_HUMAN
NC score	0.791540 (rank : 596)	θ value	1.80466e-16 (rank : 262)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1078	Shared Neighborhood Hits	827
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

DUET_HUMAN
NC score	0.790138 (rank : 597)	θ value	0.000602161 (rank : 801)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1220	Shared Neighborhood Hits	805
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

FAK2_MOUSE
NC score	0.789166 (rank : 598)	θ value	9.59137e-10 (rank : 619)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	795
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

WEE1B_MOUSE
NC score	0.788793 (rank : 599)	θ value	0.0252991 (rank : 852)
Query Neighborhood Hits	1275	Target Neighborhood Hits	765	Shared Neighborhood Hits	731
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

IRAK1_MOUSE
NC score	0.788728 (rank : 600)	θ value	1.43324e-05 (rank : 755)
Query Neighborhood Hits	1275	Target Neighborhood Hits	784	Shared Neighborhood Hits	740
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

BMX_HUMAN
NC score	0.788356 (rank : 601)	θ value	2.88788e-06 (rank : 736)
Query Neighborhood Hits	1275	Target Neighborhood Hits	942	Shared Neighborhood Hits	798
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BLK_MOUSE
NC score	0.788248 (rank : 602)	θ value	2.43908e-13 (rank : 439)
Query Neighborhood Hits	1275	Target Neighborhood Hits	992	Shared Neighborhood Hits	820
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BMX_MOUSE
NC score	0.788100 (rank : 603)	θ value	1.29631e-06 (rank : 727)
Query Neighborhood Hits	1275	Target Neighborhood Hits	912	Shared Neighborhood Hits	789
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

OBSCN_HUMAN
NC score	0.786873 (rank : 604)	θ value	4.76016e-09 (rank : 649)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1931	Shared Neighborhood Hits	925
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

HCK_HUMAN
NC score	0.786667 (rank : 605)	θ value	7.84624e-12 (rank : 514)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1035	Shared Neighborhood Hits	825
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

TXK_MOUSE
NC score	0.786199 (rank : 606)	θ value	4.59992e-12 (rank : 509)
Query Neighborhood Hits	1275	Target Neighborhood Hits	980	Shared Neighborhood Hits	804
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

SRC_MOUSE
NC score	0.785689 (rank : 607)	θ value	5.25075e-16 (rank : 298)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1033	Shared Neighborhood Hits	818
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

MYO3A_HUMAN
NC score	0.785224 (rank : 608)	θ value	2.13179e-17 (rank : 230)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1033	Shared Neighborhood Hits	845
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MKNK1_HUMAN
NC score	0.784908 (rank : 609)	θ value	4.1701e-05 (rank : 774)
Query Neighborhood Hits	1275	Target Neighborhood Hits	701	Shared Neighborhood Hits	688
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

STK40_HUMAN
NC score	0.784793 (rank : 610)	θ value	0.00665767 (rank : 833)
Query Neighborhood Hits	1275	Target Neighborhood Hits	751	Shared Neighborhood Hits	733
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

FYN_MOUSE
NC score	0.783972 (rank : 611)	θ value	1.52774e-15 (rank : 318)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1073	Shared Neighborhood Hits	828
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SRC_HUMAN
NC score	0.783858 (rank : 612)	θ value	6.85773e-16 (rank : 306)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1058	Shared Neighborhood Hits	820
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

STK40_MOUSE
NC score	0.783701 (rank : 613)	θ value	0.0330416 (rank : 855)
Query Neighborhood Hits	1275	Target Neighborhood Hits	751	Shared Neighborhood Hits	733
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

FAK2_HUMAN
NC score	0.783380 (rank : 614)	θ value	2.79066e-09 (rank : 635)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	791
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

HCK_MOUSE
NC score	0.782972 (rank : 615)	θ value	6.64225e-11 (rank : 562)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1029	Shared Neighborhood Hits	822
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

YES_HUMAN
NC score	0.780980 (rank : 616)	θ value	4.02038e-16 (rank : 287)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1059	Shared Neighborhood Hits	820
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

MYO3B_HUMAN
NC score	0.780550 (rank : 617)	θ value	1.52774e-15 (rank : 319)
Query Neighborhood Hits	1275	Target Neighborhood Hits	923	Shared Neighborhood Hits	832
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

YES_MOUSE
NC score	0.780313 (rank : 618)	θ value	5.25075e-16 (rank : 299)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1052	Shared Neighborhood Hits	818
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_HUMAN
NC score	0.776591 (rank : 619)	θ value	6.85773e-16 (rank : 301)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1067	Shared Neighborhood Hits	825
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ACK1_HUMAN
NC score	0.776186 (rank : 620)	θ value	1.63604e-09 (rank : 628)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1140	Shared Neighborhood Hits	895
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

TNK1_MOUSE
NC score	0.776123 (rank : 621)	θ value	1.09739e-05 (rank : 753)
Query Neighborhood Hits	1275	Target Neighborhood Hits	806	Shared Neighborhood Hits	773
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

ACK1_MOUSE
NC score	0.775476 (rank : 622)	θ value	1.25267e-09 (rank : 625)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1080	Shared Neighborhood Hits	882
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

EPHA5_MOUSE
NC score	0.774754 (rank : 623)	θ value	5.43371e-13 (rank : 452)
Query Neighborhood Hits	1275	Target Neighborhood Hits	950	Shared Neighborhood Hits	803
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

FGR_MOUSE
NC score	0.774534 (rank : 624)	θ value	8.95645e-16 (rank : 310)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1069	Shared Neighborhood Hits	822
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RET_MOUSE
NC score	0.773458 (rank : 625)	θ value	4.76016e-09 (rank : 650)
Query Neighborhood Hits	1275	Target Neighborhood Hits	884	Shared Neighborhood Hits	797
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

FGFR2_MOUSE
NC score	0.772678 (rank : 626)	θ value	1.58096e-12 (rank : 481)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1062	Shared Neighborhood Hits	808
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

RET_HUMAN
NC score	0.771673 (rank : 627)	θ value	6.21693e-09 (rank : 656)
Query Neighborhood Hits	1275	Target Neighborhood Hits	873	Shared Neighborhood Hits	799
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RON_HUMAN
NC score	0.771069 (rank : 628)	θ value	4.59992e-12 (rank : 505)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	794
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

FGFR2_HUMAN
NC score	0.770401 (rank : 629)	θ value	1.58096e-12 (rank : 480)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1062	Shared Neighborhood Hits	807
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

NTRK2_HUMAN
NC score	0.769887 (rank : 630)	θ value	2.88119e-14 (rank : 389)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1081	Shared Neighborhood Hits	799
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

TNK1_HUMAN
NC score	0.769691 (rank : 631)	θ value	6.43352e-06 (rank : 750)
Query Neighborhood Hits	1275	Target Neighborhood Hits	815	Shared Neighborhood Hits	775
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

NTRK2_MOUSE
NC score	0.769450 (rank : 632)	θ value	2.88119e-14 (rank : 390)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1088	Shared Neighborhood Hits	799
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

EGFR_MOUSE
NC score	0.769367 (rank : 633)	θ value	4.76016e-09 (rank : 642)
Query Neighborhood Hits	1275	Target Neighborhood Hits	927	Shared Neighborhood Hits	803
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

TTBK1_HUMAN
NC score	0.768848 (rank : 634)	θ value	1.53129e-07 (rank : 702)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1058	Shared Neighborhood Hits	773
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

EGFR_HUMAN
NC score	0.768392 (rank : 635)	θ value	1.06045e-08 (rank : 660)
Query Neighborhood Hits	1275	Target Neighborhood Hits	939	Shared Neighborhood Hits	800
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EPHB1_HUMAN
NC score	0.767004 (rank : 636)	θ value	2.60593e-15 (rank : 332)
Query Neighborhood Hits	1275	Target Neighborhood Hits	988	Shared Neighborhood Hits	802
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

LRRK1_HUMAN
NC score	0.766681 (rank : 637)	θ value	0.00175202 (rank : 816)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1237	Shared Neighborhood Hits	800
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

FGFR1_MOUSE
NC score	0.765268 (rank : 638)	θ value	1.2105e-12 (rank : 477)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1068	Shared Neighborhood Hits	811
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.765231 (rank : 639)	θ value	1.2105e-12 (rank : 476)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1069	Shared Neighborhood Hits	811
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

ERBB4_HUMAN
NC score	0.764973 (rank : 640)	θ value	3.29651e-10 (rank : 600)
Query Neighborhood Hits	1275	Target Neighborhood Hits	910	Shared Neighborhood Hits	798
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

LRRK1_MOUSE
NC score	0.763820 (rank : 641)	θ value	0.00102713 (rank : 810)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1267	Shared Neighborhood Hits	805
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

RON_MOUSE
NC score	0.762538 (rank : 642)	θ value	7.84624e-12 (rank : 519)
Query Neighborhood Hits	1275	Target Neighborhood Hits	836	Shared Neighborhood Hits	788
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

DDR2_MOUSE
NC score	0.762320 (rank : 643)	θ value	3.18553e-13 (rank : 443)
Query Neighborhood Hits	1275	Target Neighborhood Hits	813	Shared Neighborhood Hits	771
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

CTRO_HUMAN
NC score	0.761554 (rank : 644)	θ value	2.88119e-14 (rank : 384)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2092	Shared Neighborhood Hits	902
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MET_MOUSE
NC score	0.761399 (rank : 645)	θ value	1.133e-10 (rank : 574)
Query Neighborhood Hits	1275	Target Neighborhood Hits	844	Shared Neighborhood Hits	795
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

ROCK2_HUMAN
NC score	0.760831 (rank : 646)	θ value	1.9326e-10 (rank : 589)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2073	Shared Neighborhood Hits	900
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

MET_HUMAN
NC score	0.760230 (rank : 647)	θ value	1.133e-10 (rank : 573)
Query Neighborhood Hits	1275	Target Neighborhood Hits	831	Shared Neighborhood Hits	792
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

EPHA3_HUMAN
NC score	0.760139 (rank : 648)	θ value	1.42992e-13 (rank : 426)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1005	Shared Neighborhood Hits	810
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

FGFR3_HUMAN
NC score	0.759605 (rank : 649)	θ value	2.28291e-11 (rank : 539)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1042	Shared Neighborhood Hits	806
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

DDR2_HUMAN
NC score	0.759020 (rank : 650)	θ value	6.41864e-14 (rank : 403)
Query Neighborhood Hits	1275	Target Neighborhood Hits	818	Shared Neighborhood Hits	770
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

AVR2A_MOUSE
NC score	0.758897 (rank : 651)	θ value	2.21117e-06 (rank : 734)
Query Neighborhood Hits	1275	Target Neighborhood Hits	767	Shared Neighborhood Hits	757
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.758885 (rank : 652)	θ value	2.21117e-06 (rank : 733)
Query Neighborhood Hits	1275	Target Neighborhood Hits	767	Shared Neighborhood Hits	757
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

LRRK2_HUMAN
NC score	0.758196 (rank : 653)	θ value	3.41135e-07 (rank : 714)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1382	Shared Neighborhood Hits	817
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

ROCK1_HUMAN
NC score	0.758057 (rank : 654)	θ value	5.43371e-13 (rank : 458)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2000	Shared Neighborhood Hits	888
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

MRCKA_HUMAN
NC score	0.757196 (rank : 655)	θ value	8.38298e-14 (rank : 413)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1999	Shared Neighborhood Hits	888
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

EPHA5_HUMAN
NC score	0.756955 (rank : 656)	θ value	6.41864e-14 (rank : 404)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	804
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

ERBB2_MOUSE
NC score	0.756912 (rank : 657)	θ value	1.38499e-08 (rank : 661)
Query Neighborhood Hits	1275	Target Neighborhood Hits	918	Shared Neighborhood Hits	816
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

TIE2_HUMAN
NC score	0.756582 (rank : 658)	θ value	1.33837e-11 (rank : 533)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1192	Shared Neighborhood Hits	811
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

EPHA2_HUMAN
NC score	0.756187 (rank : 659)	θ value	7.58209e-15 (rank : 361)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1021	Shared Neighborhood Hits	810
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHB4_MOUSE
NC score	0.756163 (rank : 660)	θ value	1.2105e-12 (rank : 475)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1013	Shared Neighborhood Hits	801
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

ROR1_MOUSE
NC score	0.756134 (rank : 661)	θ value	3.76295e-14 (rank : 398)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1025	Shared Neighborhood Hits	805
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

FGFR3_MOUSE
NC score	0.756109 (rank : 662)	θ value	2.98157e-11 (rank : 546)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1059	Shared Neighborhood Hits	806
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

EPHA7_MOUSE
NC score	0.755971 (rank : 663)	θ value	5.43371e-13 (rank : 453)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1025	Shared Neighborhood Hits	808
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA2_MOUSE
NC score	0.755778 (rank : 664)	θ value	4.44505e-15 (rank : 349)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1020	Shared Neighborhood Hits	808
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

ROR1_HUMAN
NC score	0.755650 (rank : 665)	θ value	1.09485e-13 (rank : 422)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1018	Shared Neighborhood Hits	802
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

CDC7_HUMAN
NC score	0.755469 (rank : 666)	θ value	0.00035302 (rank : 794)
Query Neighborhood Hits	1275	Target Neighborhood Hits	652	Shared Neighborhood Hits	628
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

TIE2_MOUSE
NC score	0.755353 (rank : 667)	θ value	1.74796e-11 (rank : 538)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1204	Shared Neighborhood Hits	812
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

EPHA7_HUMAN
NC score	0.754783 (rank : 668)	θ value	7.09661e-13 (rank : 466)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1053	Shared Neighborhood Hits	809
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA3_MOUSE
NC score	0.754521 (rank : 669)	θ value	1.86753e-13 (rank : 433)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1009	Shared Neighborhood Hits	816
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ROCK2_MOUSE
NC score	0.754474 (rank : 670)	θ value	1.47974e-10 (rank : 580)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2072	Shared Neighborhood Hits	896
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

TTBK2_HUMAN
NC score	0.754472 (rank : 671)	θ value	3.77169e-06 (rank : 741)
Query Neighborhood Hits	1275	Target Neighborhood Hits	822	Shared Neighborhood Hits	727
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

EPHA1_HUMAN
NC score	0.754229 (rank : 672)	θ value	4.16044e-13 (rank : 449)
Query Neighborhood Hits	1275	Target Neighborhood Hits	997	Shared Neighborhood Hits	796
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHB4_HUMAN
NC score	0.753299 (rank : 673)	θ value	9.26847e-13 (rank : 469)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1056	Shared Neighborhood Hits	803
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

ERBB2_HUMAN
NC score	0.752816 (rank : 674)	θ value	2.36244e-08 (rank : 673)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1073	Shared Neighborhood Hits	823
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

TTBK2_MOUSE
NC score	0.751967 (rank : 675)	θ value	2.21117e-06 (rank : 735)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	717
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

FGFR4_HUMAN
NC score	0.749406 (rank : 676)	θ value	1.9326e-10 (rank : 584)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1037	Shared Neighborhood Hits	795
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

EPHB2_MOUSE
NC score	0.748998 (rank : 677)	θ value	5.43371e-13 (rank : 455)
Query Neighborhood Hits	1275	Target Neighborhood Hits	982	Shared Neighborhood Hits	801
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.748830 (rank : 678)	θ value	5.43371e-13 (rank : 454)
Query Neighborhood Hits	1275	Target Neighborhood Hits	983	Shared Neighborhood Hits	801
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

STYK1_HUMAN
NC score	0.748578 (rank : 679)	θ value	3.41135e-07 (rank : 715)
Query Neighborhood Hits	1275	Target Neighborhood Hits	786	Shared Neighborhood Hits	763
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

KC1AL_HUMAN
NC score	0.748308 (rank : 680)	θ value	2.52405e-10 (rank : 593)
Query Neighborhood Hits	1275	Target Neighborhood Hits	734	Shared Neighborhood Hits	728
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

EPHA4_HUMAN
NC score	0.747295 (rank : 681)	θ value	1.09485e-13 (rank : 414)
Query Neighborhood Hits	1275	Target Neighborhood Hits	975	Shared Neighborhood Hits	802
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
NC score	0.747031 (rank : 682)	θ value	1.09485e-13 (rank : 415)
Query Neighborhood Hits	1275	Target Neighborhood Hits	982	Shared Neighborhood Hits	802
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

KC1A_HUMAN
NC score	0.746822 (rank : 683)	θ value	2.52405e-10 (rank : 594)
Query Neighborhood Hits	1275	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.746822 (rank : 684)	θ value	2.52405e-10 (rank : 595)
Query Neighborhood Hits	1275	Target Neighborhood Hits	728	Shared Neighborhood Hits	725
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

NTRK1_HUMAN
NC score	0.746751 (rank : 685)	θ value	1.09485e-13 (rank : 421)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1023	Shared Neighborhood Hits	783
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

EPHA1_MOUSE
NC score	0.745594 (rank : 686)	θ value	9.26847e-13 (rank : 468)
Query Neighborhood Hits	1275	Target Neighborhood Hits	958	Shared Neighborhood Hits	784
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHB3_HUMAN
NC score	0.745308 (rank : 687)	θ value	2.88119e-14 (rank : 385)
Query Neighborhood Hits	1275	Target Neighborhood Hits	996	Shared Neighborhood Hits	804
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

CDC7_MOUSE
NC score	0.744323 (rank : 688)	θ value	0.00228821 (rank : 820)
Query Neighborhood Hits	1275	Target Neighborhood Hits	641	Shared Neighborhood Hits	625
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

EPHB3_MOUSE
NC score	0.744005 (rank : 689)	θ value	8.38298e-14 (rank : 410)
Query Neighborhood Hits	1275	Target Neighborhood Hits	996	Shared Neighborhood Hits	804
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

LRRK2_MOUSE
NC score	0.743883 (rank : 690)	θ value	4.45536e-07 (rank : 719)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1359	Shared Neighborhood Hits	811
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

MRCKB_MOUSE
NC score	0.743080 (rank : 691)	θ value	3.76295e-14 (rank : 397)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2180	Shared Neighborhood Hits	899
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

INSR_HUMAN
NC score	0.742877 (rank : 692)	θ value	1.9326e-10 (rank : 585)
Query Neighborhood Hits	1275	Target Neighborhood Hits	963	Shared Neighborhood Hits	802
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ROCK1_MOUSE
NC score	0.742650 (rank : 693)	θ value	5.43371e-13 (rank : 459)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2126	Shared Neighborhood Hits	897
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

EPHA8_HUMAN
NC score	0.742024 (rank : 694)	θ value	1.47974e-10 (rank : 579)
Query Neighborhood Hits	1275	Target Neighborhood Hits	956	Shared Neighborhood Hits	797
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

ACVR1_MOUSE
NC score	0.741934 (rank : 695)	θ value	7.59969e-07 (rank : 720)
Query Neighborhood Hits	1275	Target Neighborhood Hits	768	Shared Neighborhood Hits	753
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

TGFR2_HUMAN
NC score	0.741787 (rank : 696)	θ value	0.000602161 (rank : 804)
Query Neighborhood Hits	1275	Target Neighborhood Hits	748	Shared Neighborhood Hits	736
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

CTRO_MOUSE
NC score	0.741359 (rank : 697)	θ value	1.42992e-13 (rank : 425)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2344	Shared Neighborhood Hits	919
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

TGFR2_MOUSE
NC score	0.741042 (rank : 698)	θ value	0.000602161 (rank : 805)
Query Neighborhood Hits	1275	Target Neighborhood Hits	748	Shared Neighborhood Hits	737
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

INSR_MOUSE
NC score	0.739074 (rank : 699)	θ value	4.30538e-10 (rank : 603)
Query Neighborhood Hits	1275	Target Neighborhood Hits	968	Shared Neighborhood Hits	800
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

AVR2B_MOUSE
NC score	0.738652 (rank : 700)	θ value	0.000121331 (rank : 784)
Query Neighborhood Hits	1275	Target Neighborhood Hits	749	Shared Neighborhood Hits	735
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.738640 (rank : 701)	θ value	0.000121331 (rank : 783)
Query Neighborhood Hits	1275	Target Neighborhood Hits	748	Shared Neighborhood Hits	735
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

BMR1A_HUMAN
NC score	0.737229 (rank : 702)	θ value	1.17247e-07 (rank : 693)
Query Neighborhood Hits	1275	Target Neighborhood Hits	759	Shared Neighborhood Hits	742
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

AATK_HUMAN
NC score	0.736987 (rank : 703)	θ value	0.00298849 (rank : 824)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1243	Shared Neighborhood Hits	836
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

EPHA8_MOUSE
NC score	0.736679 (rank : 704)	θ value	2.52405e-10 (rank : 592)
Query Neighborhood Hits	1275	Target Neighborhood Hits	969	Shared Neighborhood Hits	795
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

ACVR1_HUMAN
NC score	0.736350 (rank : 705)	θ value	9.92553e-07 (rank : 725)
Query Neighborhood Hits	1275	Target Neighborhood Hits	760	Shared Neighborhood Hits	747
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

TNI3K_MOUSE
NC score	0.736155 (rank : 706)	θ value	4.59992e-12 (rank : 508)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1079	Shared Neighborhood Hits	790
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

MRCKB_HUMAN
NC score	0.736114 (rank : 707)	θ value	1.68911e-14 (rank : 372)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2239	Shared Neighborhood Hits	905
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

BMR1A_MOUSE
NC score	0.735920 (rank : 708)	θ value	1.17247e-07 (rank : 694)
Query Neighborhood Hits	1275	Target Neighborhood Hits	758	Shared Neighborhood Hits	742
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

ROS_HUMAN
NC score	0.735878 (rank : 709)	θ value	2.61198e-07 (rank : 710)
Query Neighborhood Hits	1275	Target Neighborhood Hits	907	Shared Neighborhood Hits	764
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

KC1D_HUMAN
NC score	0.735476 (rank : 710)	θ value	4.45536e-07 (rank : 717)
Query Neighborhood Hits	1275	Target Neighborhood Hits	737	Shared Neighborhood Hits	726
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.735474 (rank : 711)	θ value	4.45536e-07 (rank : 718)
Query Neighborhood Hits	1275	Target Neighborhood Hits	737	Shared Neighborhood Hits	726
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

ROR2_HUMAN
NC score	0.735377 (rank : 712)	θ value	5.26297e-08 (rank : 685)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1014	Shared Neighborhood Hits	787
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

TIE1_MOUSE
NC score	0.733658 (rank : 713)	θ value	1.9326e-10 (rank : 591)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1266	Shared Neighborhood Hits	813
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_HUMAN
NC score	0.733085 (rank : 714)	θ value	6.64225e-11 (rank : 565)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1241	Shared Neighborhood Hits	814
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

NTRK3_HUMAN
NC score	0.732953 (rank : 715)	θ value	6.00763e-12 (rank : 513)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1115	Shared Neighborhood Hits	788
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

UFO_MOUSE
NC score	0.732914 (rank : 716)	θ value	9.59137e-10 (rank : 624)
Query Neighborhood Hits	1275	Target Neighborhood Hits	988	Shared Neighborhood Hits	761
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

STYK1_MOUSE
NC score	0.732331 (rank : 717)	θ value	0.00035302 (rank : 796)
Query Neighborhood Hits	1275	Target Neighborhood Hits	779	Shared Neighborhood Hits	759
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

PINK1_MOUSE
NC score	0.731248 (rank : 718)	θ value	6.88961 (rank : 1221)
Query Neighborhood Hits	1275	Target Neighborhood Hits	726	Shared Neighborhood Hits	712
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

TNI3K_HUMAN
NC score	0.731092 (rank : 719)	θ value	1.02475e-11 (rank : 526)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1084	Shared Neighborhood Hits	795
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

DDR1_MOUSE
NC score	0.729978 (rank : 720)	θ value	8.97725e-08 (rank : 687)
Query Neighborhood Hits	1275	Target Neighborhood Hits	818	Shared Neighborhood Hits	766
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.729571 (rank : 721)	θ value	3.08544e-08 (rank : 675)
Query Neighborhood Hits	1275	Target Neighborhood Hits	819	Shared Neighborhood Hits	767
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

FGFR4_MOUSE
NC score	0.729520 (rank : 722)	θ value	2.79066e-09 (rank : 636)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1026	Shared Neighborhood Hits	785
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

KC1E_HUMAN
NC score	0.729507 (rank : 723)	θ value	1.69304e-06 (rank : 730)
Query Neighborhood Hits	1275	Target Neighborhood Hits	732	Shared Neighborhood Hits	724
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

UFO_HUMAN
NC score	0.729496 (rank : 724)	θ value	9.59137e-10 (rank : 623)
Query Neighborhood Hits	1275	Target Neighborhood Hits	981	Shared Neighborhood Hits	763
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

KC1E_MOUSE
NC score	0.729496 (rank : 725)	θ value	1.69304e-06 (rank : 731)
Query Neighborhood Hits	1275	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

BMR1B_MOUSE
NC score	0.728556 (rank : 726)	θ value	2.61198e-07 (rank : 708)
Query Neighborhood Hits	1275	Target Neighborhood Hits	758	Shared Neighborhood Hits	741
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

ERBB3_MOUSE
NC score	0.727807 (rank : 727)	θ value	3.41135e-07 (rank : 713)
Query Neighborhood Hits	1275	Target Neighborhood Hits	898	Shared Neighborhood Hits	774
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

MERTK_MOUSE
NC score	0.727750 (rank : 728)	θ value	6.64225e-11 (rank : 563)
Query Neighborhood Hits	1275	Target Neighborhood Hits	974	Shared Neighborhood Hits	761
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

AATK_MOUSE
NC score	0.727538 (rank : 729)	θ value	0.0113563 (rank : 836)
Query Neighborhood Hits	1275	Target Neighborhood Hits	942	Shared Neighborhood Hits	793
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

BMR1B_HUMAN
NC score	0.727088 (rank : 730)	θ value	3.41135e-07 (rank : 712)
Query Neighborhood Hits	1275	Target Neighborhood Hits	760	Shared Neighborhood Hits	740
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

MLKL_MOUSE
NC score	0.727047 (rank : 731)	θ value	0.00175202 (rank : 817)
Query Neighborhood Hits	1275	Target Neighborhood Hits	707	Shared Neighborhood Hits	688
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

IGF1R_MOUSE
NC score	0.725868 (rank : 732)	θ value	8.97725e-08 (rank : 689)
Query Neighborhood Hits	1275	Target Neighborhood Hits	973	Shared Neighborhood Hits	787
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ERBB3_HUMAN
NC score	0.725447 (rank : 733)	θ value	9.92553e-07 (rank : 726)
Query Neighborhood Hits	1275	Target Neighborhood Hits	918	Shared Neighborhood Hits	777
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

PINK1_HUMAN
NC score	0.725444 (rank : 734)	θ value	3.0926 (rank : 1104)
Query Neighborhood Hits	1275	Target Neighborhood Hits	741	Shared Neighborhood Hits	713
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

IGF1R_HUMAN
NC score	0.725002 (rank : 735)	θ value	1.53129e-07 (rank : 700)
Query Neighborhood Hits	1275	Target Neighborhood Hits	977	Shared Neighborhood Hits	787
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_MOUSE
NC score	0.724693 (rank : 736)	θ value	9.59137e-10 (rank : 620)
Query Neighborhood Hits	1275	Target Neighborhood Hits	961	Shared Neighborhood Hits	776
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_HUMAN
NC score	0.724539 (rank : 737)	θ value	2.13673e-09 (rank : 633)
Query Neighborhood Hits	1275	Target Neighborhood Hits	950	Shared Neighborhood Hits	775
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PGFRA_HUMAN
NC score	0.723042 (rank : 738)	θ value	3.64472e-09 (rank : 638)
Query Neighborhood Hits	1275	Target Neighborhood Hits	980	Shared Neighborhood Hits	786
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

BMPR2_HUMAN
NC score	0.722438 (rank : 739)	θ value	1.53129e-07 (rank : 699)
Query Neighborhood Hits	1275	Target Neighborhood Hits	736	Shared Neighborhood Hits	701
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

PGFRA_MOUSE
NC score	0.721607 (rank : 740)	θ value	3.64472e-09 (rank : 639)
Query Neighborhood Hits	1275	Target Neighborhood Hits	975	Shared Neighborhood Hits	783
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

BMPR2_MOUSE
NC score	0.721455 (rank : 741)	θ value	2.61198e-07 (rank : 707)
Query Neighborhood Hits	1275	Target Neighborhood Hits	738	Shared Neighborhood Hits	702
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

MERTK_HUMAN
NC score	0.720731 (rank : 742)	θ value	2.28291e-11 (rank : 541)
Query Neighborhood Hits	1275	Target Neighborhood Hits	988	Shared Neighborhood Hits	772
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

TRIB2_HUMAN
NC score	0.720606 (rank : 743)	θ value	θ > 10 (rank : 1410)
Query Neighborhood Hits	1275	Target Neighborhood Hits	657	Shared Neighborhood Hits	646
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TYRO3_HUMAN
NC score	0.720425 (rank : 744)	θ value	1.80886e-08 (rank : 669)
Query Neighborhood Hits	1275	Target Neighborhood Hits	995	Shared Neighborhood Hits	774
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TRIB2_MOUSE
NC score	0.719740 (rank : 745)	θ value	θ > 10 (rank : 1411)
Query Neighborhood Hits	1275	Target Neighborhood Hits	653	Shared Neighborhood Hits	642
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TYRO3_MOUSE
NC score	0.719703 (rank : 746)	θ value	1.38499e-08 (rank : 664)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1007	Shared Neighborhood Hits	774
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

KIT_HUMAN
NC score	0.716113 (rank : 747)	θ value	2.13673e-09 (rank : 634)
Query Neighborhood Hits	1275	Target Neighborhood Hits	953	Shared Neighborhood Hits	787
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

PGFRB_HUMAN
NC score	0.715734 (rank : 748)	θ value	3.08544e-08 (rank : 679)
Query Neighborhood Hits	1275	Target Neighborhood Hits	962	Shared Neighborhood Hits	781
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

VGFR3_MOUSE
NC score	0.715493 (rank : 749)	θ value	1.80886e-08 (rank : 671)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1056	Shared Neighborhood Hits	784
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

PGFRB_MOUSE
NC score	0.715439 (rank : 750)	θ value	8.97725e-08 (rank : 690)
Query Neighborhood Hits	1275	Target Neighborhood Hits	960	Shared Neighborhood Hits	786
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

KC1G1_MOUSE
NC score	0.715221 (rank : 751)	θ value	3.19293e-05 (rank : 768)
Query Neighborhood Hits	1275	Target Neighborhood Hits	713	Shared Neighborhood Hits	706
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

VGFR3_HUMAN
NC score	0.714952 (rank : 752)	θ value	1.38499e-08 (rank : 666)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1037	Shared Neighborhood Hits	786
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

RPKL1_MOUSE
NC score	0.714935 (rank : 753)	θ value	6.43352e-06 (rank : 749)
Query Neighborhood Hits	1275	Target Neighborhood Hits	704	Shared Neighborhood Hits	660
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

KC1G1_HUMAN
NC score	0.713906 (rank : 754)	θ value	3.19293e-05 (rank : 767)
Query Neighborhood Hits	1275	Target Neighborhood Hits	708	Shared Neighborhood Hits	704
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

TGFR1_HUMAN
NC score	0.713669 (rank : 755)	θ value	9.29e-05 (rank : 779)
Query Neighborhood Hits	1275	Target Neighborhood Hits	755	Shared Neighborhood Hits	743
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.713369 (rank : 756)	θ value	9.29e-05 (rank : 780)
Query Neighborhood Hits	1275	Target Neighborhood Hits	753	Shared Neighborhood Hits	743
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

ROR2_MOUSE
NC score	0.712806 (rank : 757)	θ value	2.61198e-07 (rank : 709)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1000	Shared Neighborhood Hits	765
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

IRAK2_HUMAN
NC score	0.712501 (rank : 758)	θ value	0.000270298 (rank : 791)
Query Neighborhood Hits	1275	Target Neighborhood Hits	714	Shared Neighborhood Hits	681
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

FLT3_HUMAN
NC score	0.712285 (rank : 759)	θ value	8.97725e-08 (rank : 688)
Query Neighborhood Hits	1275	Target Neighborhood Hits	843	Shared Neighborhood Hits	779
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

KC1G3_HUMAN
NC score	0.710809 (rank : 760)	θ value	3.19293e-05 (rank : 769)
Query Neighborhood Hits	1275	Target Neighborhood Hits	711	Shared Neighborhood Hits	707
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

VGFR1_MOUSE
NC score	0.710426 (rank : 761)	θ value	1.80886e-08 (rank : 670)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1118	Shared Neighborhood Hits	801
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

FLT3_MOUSE
NC score	0.709416 (rank : 762)	θ value	5.26297e-08 (rank : 684)
Query Neighborhood Hits	1275	Target Neighborhood Hits	847	Shared Neighborhood Hits	778
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

EPHA6_MOUSE
NC score	0.709294 (rank : 763)	θ value	1.42992e-13 (rank : 427)
Query Neighborhood Hits	1275	Target Neighborhood Hits	946	Shared Neighborhood Hits	792
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

KIT_MOUSE
NC score	0.708933 (rank : 764)	θ value	4.76016e-09 (rank : 646)
Query Neighborhood Hits	1275	Target Neighborhood Hits	949	Shared Neighborhood Hits	784
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

TOPK_MOUSE
NC score	0.708766 (rank : 765)	θ value	0.000786445 (rank : 808)
Query Neighborhood Hits	1275	Target Neighborhood Hits	618	Shared Neighborhood Hits	600
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

ACV1B_MOUSE
NC score	0.706012 (rank : 766)	θ value	0.00020696 (rank : 788)
Query Neighborhood Hits	1275	Target Neighborhood Hits	753	Shared Neighborhood Hits	743
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.705718 (rank : 767)	θ value	0.00020696 (rank : 787)
Query Neighborhood Hits	1275	Target Neighborhood Hits	753	Shared Neighborhood Hits	744
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

VGFR2_MOUSE
NC score	0.704994 (rank : 768)	θ value	8.11959e-09 (rank : 659)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1089	Shared Neighborhood Hits	790
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

EPHA6_HUMAN
NC score	0.704977 (rank : 769)	θ value	7.09661e-13 (rank : 465)
Query Neighborhood Hits	1275	Target Neighborhood Hits	959	Shared Neighborhood Hits	787
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

RPKL1_HUMAN
NC score	0.702775 (rank : 770)	θ value	6.43352e-06 (rank : 748)
Query Neighborhood Hits	1275	Target Neighborhood Hits	708	Shared Neighborhood Hits	652
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

VGFR1_HUMAN
NC score	0.702674 (rank : 771)	θ value	1.38499e-08 (rank : 665)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1109	Shared Neighborhood Hits	798
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

MUSK_HUMAN
NC score	0.702296 (rank : 772)	θ value	5.08577e-11 (rank : 560)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1074	Shared Neighborhood Hits	781
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

VGFR2_HUMAN
NC score	0.701470 (rank : 773)	θ value	8.11959e-09 (rank : 658)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1103	Shared Neighborhood Hits	792
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

TOPK_HUMAN
NC score	0.700158 (rank : 774)	θ value	0.00134147 (rank : 815)
Query Neighborhood Hits	1275	Target Neighborhood Hits	605	Shared Neighborhood Hits	587
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

ACVL1_MOUSE
NC score	0.699047 (rank : 775)	θ value	0.000158464 (rank : 786)
Query Neighborhood Hits	1275	Target Neighborhood Hits	739	Shared Neighborhood Hits	729
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

LTK_MOUSE
NC score	0.698919 (rank : 776)	θ value	1.80886e-08 (rank : 668)
Query Neighborhood Hits	1275	Target Neighborhood Hits	770	Shared Neighborhood Hits	743
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

MUSK_MOUSE
NC score	0.697680 (rank : 777)	θ value	8.67504e-11 (rank : 570)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1057	Shared Neighborhood Hits	777
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

PTK7_HUMAN
NC score	0.696413 (rank : 778)	θ value	5.62301e-10 (rank : 614)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1103	Shared Neighborhood Hits	773
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

TITIN_HUMAN
NC score	0.694286 (rank : 779)	θ value	2.28291e-11 (rank : 545)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2923	Shared Neighborhood Hits	989
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ALK_HUMAN
NC score	0.693783 (rank : 780)	θ value	1.53129e-07 (rank : 698)
Query Neighborhood Hits	1275	Target Neighborhood Hits	795	Shared Neighborhood Hits	738
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LTK_HUMAN
NC score	0.693237 (rank : 781)	θ value	1.53129e-07 (rank : 701)
Query Neighborhood Hits	1275	Target Neighborhood Hits	774	Shared Neighborhood Hits	746
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

KS6C1_MOUSE
NC score	0.693081 (rank : 782)	θ value	2.44474e-05 (rank : 762)
Query Neighborhood Hits	1275	Target Neighborhood Hits	700	Shared Neighborhood Hits	633
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

ALK_MOUSE
NC score	0.691159 (rank : 783)	θ value	3.41135e-07 (rank : 711)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	749
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

KS6C1_HUMAN
NC score	0.688055 (rank : 784)	θ value	3.19293e-05 (rank : 770)
Query Neighborhood Hits	1275	Target Neighborhood Hits	682	Shared Neighborhood Hits	637
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KC1G2_MOUSE
NC score	0.683756 (rank : 785)	θ value	0.000270298 (rank : 792)
Query Neighborhood Hits	1275	Target Neighborhood Hits	695	Shared Neighborhood Hits	691
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

CSF1R_HUMAN
NC score	0.683478 (rank : 786)	θ value	2.36244e-08 (rank : 672)
Query Neighborhood Hits	1275	Target Neighborhood Hits	943	Shared Neighborhood Hits	781
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

KC1G2_HUMAN
NC score	0.682841 (rank : 787)	θ value	0.000461057 (rank : 799)
Query Neighborhood Hits	1275	Target Neighborhood Hits	693	Shared Neighborhood Hits	690
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

ACVL1_HUMAN
NC score	0.677154 (rank : 788)	θ value	0.000461057 (rank : 797)
Query Neighborhood Hits	1275	Target Neighborhood Hits	716	Shared Neighborhood Hits	707
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

CSF1R_MOUSE
NC score	0.676106 (rank : 789)	θ value	4.0297e-08 (rank : 680)
Query Neighborhood Hits	1275	Target Neighborhood Hits	983	Shared Neighborhood Hits	779
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

TRIB1_HUMAN
NC score	0.673477 (rank : 790)	θ value	4.03905 (rank : 1137)
Query Neighborhood Hits	1275	Target Neighborhood Hits	598	Shared Neighborhood Hits	579
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
NC score	0.672559 (rank : 791)	θ value	5.27518 (rank : 1183)
Query Neighborhood Hits	1275	Target Neighborhood Hits	593	Shared Neighborhood Hits	581
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB3_MOUSE
NC score	0.664676 (rank : 792)	θ value	0.000602161 (rank : 806)
Query Neighborhood Hits	1275	Target Neighborhood Hits	578	Shared Neighborhood Hits	571
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

SRPK1_MOUSE
NC score	0.663886 (rank : 793)	θ value	3.77169e-06 (rank : 740)
Query Neighborhood Hits	1275	Target Neighborhood Hits	639	Shared Neighborhood Hits	572
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

ACV1C_MOUSE
NC score	0.662196 (rank : 794)	θ value	4.1701e-05 (rank : 773)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	698
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

IRAK3_MOUSE
NC score	0.661495 (rank : 795)	θ value	0.000786445 (rank : 807)
Query Neighborhood Hits	1275	Target Neighborhood Hits	628	Shared Neighborhood Hits	603
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ANKK1_MOUSE
NC score	0.660341 (rank : 796)	θ value	1.17247e-07 (rank : 692)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1072	Shared Neighborhood Hits	793
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

RIPK4_HUMAN
NC score	0.659794 (rank : 797)	θ value	2.44474e-05 (rank : 764)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1094	Shared Neighborhood Hits	802
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

SRPK1_HUMAN
NC score	0.659791 (rank : 798)	θ value	1.69304e-06 (rank : 732)
Query Neighborhood Hits	1275	Target Neighborhood Hits	706	Shared Neighborhood Hits	585
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

RYK_MOUSE
NC score	0.658311 (rank : 799)	θ value	0.00020696 (rank : 789)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	694
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

IRAK3_HUMAN
NC score	0.658013 (rank : 800)	θ value	0.00228821 (rank : 821)
Query Neighborhood Hits	1275	Target Neighborhood Hits	644	Shared Neighborhood Hits	624
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ACV1C_HUMAN
NC score	0.655868 (rank : 801)	θ value	0.000121331 (rank : 781)
Query Neighborhood Hits	1275	Target Neighborhood Hits	709	Shared Neighborhood Hits	692
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

STK23_MOUSE
NC score	0.649086 (rank : 802)	θ value	4.1701e-05 (rank : 776)
Query Neighborhood Hits	1275	Target Neighborhood Hits	572	Shared Neighborhood Hits	556
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SRPK2_MOUSE
NC score	0.647518 (rank : 803)	θ value	4.92598e-06 (rank : 746)
Query Neighborhood Hits	1275	Target Neighborhood Hits	765	Shared Neighborhood Hits	590
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STK23_HUMAN
NC score	0.647211 (rank : 804)	θ value	4.1701e-05 (rank : 775)
Query Neighborhood Hits	1275	Target Neighborhood Hits	556	Shared Neighborhood Hits	550
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SRPK2_HUMAN
NC score	0.647167 (rank : 805)	θ value	4.92598e-06 (rank : 745)
Query Neighborhood Hits	1275	Target Neighborhood Hits	664	Shared Neighborhood Hits	574
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

ANKK1_HUMAN
NC score	0.645978 (rank : 806)	θ value	3.08544e-08 (rank : 674)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1075	Shared Neighborhood Hits	789
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

RYK_HUMAN
NC score	0.642045 (rank : 807)	θ value	0.00035302 (rank : 795)
Query Neighborhood Hits	1275	Target Neighborhood Hits	701	Shared Neighborhood Hits	682
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

EPHAA_HUMAN
NC score	0.639540 (rank : 808)	θ value	2.44474e-05 (rank : 759)
Query Neighborhood Hits	1275	Target Neighborhood Hits	960	Shared Neighborhood Hits	732
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB6_MOUSE
NC score	0.632906 (rank : 809)	θ value	3.77169e-06 (rank : 738)
Query Neighborhood Hits	1275	Target Neighborhood Hits	906	Shared Neighborhood Hits	705
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

TRIB3_HUMAN
NC score	0.630413 (rank : 810)	θ value	0.0563607 (rank : 865)
Query Neighborhood Hits	1275	Target Neighborhood Hits	519	Shared Neighborhood Hits	510
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

MLKL_HUMAN
NC score	0.619760 (rank : 811)	θ value	θ > 10 (rank : 1323)
Query Neighborhood Hits	1275	Target Neighborhood Hits	600	Shared Neighborhood Hits	570
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

GUC2F_HUMAN
NC score	0.614776 (rank : 812)	θ value	2.44474e-05 (rank : 761)
Query Neighborhood Hits	1275	Target Neighborhood Hits	740	Shared Neighborhood Hits	673
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

EPHB6_HUMAN
NC score	0.611181 (rank : 813)	θ value	2.44474e-05 (rank : 760)
Query Neighborhood Hits	1275	Target Neighborhood Hits	912	Shared Neighborhood Hits	682
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

AMHR2_HUMAN
NC score	0.601546 (rank : 814)	θ value	0.365318 (rank : 915)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	656
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

SCYL2_HUMAN
NC score	0.588896 (rank : 815)	θ value	θ > 10 (rank : 1379)
Query Neighborhood Hits	1275	Target Neighborhood Hits	632	Shared Neighborhood Hits	562
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
NC score	0.568229 (rank : 816)	θ value	θ > 10 (rank : 1380)
Query Neighborhood Hits	1275	Target Neighborhood Hits	603	Shared Neighborhood Hits	542
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

GUC2D_HUMAN
NC score	0.560890 (rank : 817)	θ value	1.09739e-05 (rank : 751)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	661
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

BUB1_MOUSE
NC score	0.555306 (rank : 818)	θ value	θ > 10 (rank : 1282)
Query Neighborhood Hits	1275	Target Neighborhood Hits	583	Shared Neighborhood Hits	538
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

GUC2G_MOUSE
NC score	0.552358 (rank : 819)	θ value	3.19293e-05 (rank : 766)
Query Neighborhood Hits	1275	Target Neighborhood Hits	644	Shared Neighborhood Hits	579
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GUC2C_HUMAN
NC score	0.544264 (rank : 820)	θ value	θ > 10 (rank : 1313)
Query Neighborhood Hits	1275	Target Neighborhood Hits	624	Shared Neighborhood Hits	577
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

VRK2_MOUSE
NC score	0.542667 (rank : 821)	θ value	3.77169e-06 (rank : 742)
Query Neighborhood Hits	1275	Target Neighborhood Hits	586	Shared Neighborhood Hits	578
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

GUC2E_MOUSE
NC score	0.539661 (rank : 822)	θ value	3.19293e-05 (rank : 765)
Query Neighborhood Hits	1275	Target Neighborhood Hits	692	Shared Neighborhood Hits	637
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

TEX14_MOUSE
NC score	0.539484 (rank : 823)	θ value	0.813845 (rank : 991)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1333	Shared Neighborhood Hits	695
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ANPRB_HUMAN
NC score	0.537120 (rank : 824)	θ value	θ > 10 (rank : 1276)
Query Neighborhood Hits	1275	Target Neighborhood Hits	646	Shared Neighborhood Hits	575
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

VRK1_MOUSE
NC score	0.536522 (rank : 825)	θ value	7.59969e-07 (rank : 724)
Query Neighborhood Hits	1275	Target Neighborhood Hits	583	Shared Neighborhood Hits	576
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK2_HUMAN
NC score	0.534589 (rank : 826)	θ value	1.43324e-05 (rank : 756)
Query Neighborhood Hits	1275	Target Neighborhood Hits	582	Shared Neighborhood Hits	564
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_HUMAN
NC score	0.533110 (rank : 827)	θ value	1.53129e-07 (rank : 703)
Query Neighborhood Hits	1275	Target Neighborhood Hits	584	Shared Neighborhood Hits	575
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

ANPRA_HUMAN
NC score	0.519753 (rank : 828)	θ value	2.44474e-05 (rank : 758)
Query Neighborhood Hits	1275	Target Neighborhood Hits	612	Shared Neighborhood Hits	543
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
NC score	0.514151 (rank : 829)	θ value	1.87187e-05 (rank : 757)
Query Neighborhood Hits	1275	Target Neighborhood Hits	600	Shared Neighborhood Hits	534
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRB_MOUSE
NC score	0.509351 (rank : 830)	θ value	θ > 10 (rank : 1277)
Query Neighborhood Hits	1275	Target Neighborhood Hits	607	Shared Neighborhood Hits	552
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

TEX14_HUMAN
NC score	0.489838 (rank : 831)	θ value	8.99809 (rank : 1269)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1103	Shared Neighborhood Hits	624
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

NRBP_HUMAN
NC score	0.488899 (rank : 832)	θ value	θ > 10 (rank : 1346)
Query Neighborhood Hits	1275	Target Neighborhood Hits	448	Shared Neighborhood Hits	420
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
NC score	0.486736 (rank : 833)	θ value	θ > 10 (rank : 1347)
Query Neighborhood Hits	1275	Target Neighborhood Hits	442	Shared Neighborhood Hits	416
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

ILK1_HUMAN
NC score	0.457806 (rank : 834)	θ value	θ > 10 (rank : 1315)
Query Neighborhood Hits	1275	Target Neighborhood Hits	857	Shared Neighborhood Hits	592
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.456775 (rank : 835)	θ value	θ > 10 (rank : 1317)
Query Neighborhood Hits	1275	Target Neighborhood Hits	858	Shared Neighborhood Hits	593
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK2_HUMAN
NC score	0.443407 (rank : 836)	θ value	θ > 10 (rank : 1316)
Query Neighborhood Hits	1275	Target Neighborhood Hits	848	Shared Neighborhood Hits	583
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

NTKL_MOUSE
NC score	0.381824 (rank : 837)	θ value	0.813845 (rank : 979)
Query Neighborhood Hits	1275	Target Neighborhood Hits	326	Shared Neighborhood Hits	290
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

PI3R4_MOUSE
NC score	0.380016 (rank : 838)	θ value	0.0193708 (rank : 845)
Query Neighborhood Hits	1275	Target Neighborhood Hits	535	Shared Neighborhood Hits	354
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

BUB1_HUMAN
NC score	0.375955 (rank : 839)	θ value	0.47712 (rank : 930)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	408
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

STK31_HUMAN
NC score	0.371031 (rank : 840)	θ value	0.000461057 (rank : 800)
Query Neighborhood Hits	1275	Target Neighborhood Hits	570	Shared Neighborhood Hits	382
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

PI3R4_HUMAN
NC score	0.368015 (rank : 841)	θ value	0.0330416 (rank : 853)
Query Neighborhood Hits	1275	Target Neighborhood Hits	534	Shared Neighborhood Hits	351
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

RN5A_MOUSE
NC score	0.356315 (rank : 842)	θ value	0.0330416 (rank : 854)
Query Neighborhood Hits	1275	Target Neighborhood Hits	899	Shared Neighborhood Hits	612
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

STK31_MOUSE
NC score	0.302237 (rank : 843)	θ value	θ > 10 (rank : 1409)
Query Neighborhood Hits	1275	Target Neighborhood Hits	474	Shared Neighborhood Hits	323
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

NTKL_HUMAN
NC score	0.292281 (rank : 844)	θ value	8.99809 (rank : 1257)
Query Neighborhood Hits	1275	Target Neighborhood Hits	266	Shared Neighborhood Hits	229
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

VRK3_MOUSE
NC score	0.286900 (rank : 845)	θ value	0.0563607 (rank : 866)
Query Neighborhood Hits	1275	Target Neighborhood Hits	342	Shared Neighborhood Hits	323
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VRK3_HUMAN
NC score	0.286405 (rank : 846)	θ value	0.163984 (rank : 892)
Query Neighborhood Hits	1275	Target Neighborhood Hits	349	Shared Neighborhood Hits	321
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

K2002_HUMAN
NC score	0.285973 (rank : 847)	θ value	θ > 10 (rank : 1318)
Query Neighborhood Hits	1275	Target Neighborhood Hits	274	Shared Neighborhood Hits	260
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

K2002_MOUSE
NC score	0.234950 (rank : 848)	θ value	θ > 10 (rank : 1319)
Query Neighborhood Hits	1275	Target Neighborhood Hits	267	Shared Neighborhood Hits	230
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

PXK_MOUSE
NC score	0.185039 (rank : 849)	θ value	0.0563607 (rank : 863)
Query Neighborhood Hits	1275	Target Neighborhood Hits	320	Shared Neighborhood Hits	219
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PRPK_MOUSE
NC score	0.153302 (rank : 850)	θ value	θ > 10 (rank : 1366)
Query Neighborhood Hits	1275	Target Neighborhood Hits	139	Shared Neighborhood Hits	133
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

RN5A_HUMAN
NC score	0.151331 (rank : 851)	θ value	θ > 10 (rank : 1372)
Query Neighborhood Hits	1275	Target Neighborhood Hits	608	Shared Neighborhood Hits	336
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

SLAP2_MOUSE
NC score	0.145462 (rank : 852)	θ value	θ > 10 (rank : 1402)
Query Neighborhood Hits	1275	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.141402 (rank : 853)	θ value	θ > 10 (rank : 1401)
Query Neighborhood Hits	1275	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

PRPK_HUMAN
NC score	0.141384 (rank : 854)	θ value	θ > 10 (rank : 1365)
Query Neighborhood Hits	1275	Target Neighborhood Hits	131	Shared Neighborhood Hits	129
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

SLAP1_HUMAN
NC score	0.141053 (rank : 855)	θ value	θ > 10 (rank : 1399)
Query Neighborhood Hits	1275	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.139045 (rank : 856)	θ value	θ > 10 (rank : 1400)
Query Neighborhood Hits	1275	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

PXK_HUMAN
NC score	0.134278 (rank : 857)	θ value	2.36792 (rank : 1078)
Query Neighborhood Hits	1275	Target Neighborhood Hits	216	Shared Neighborhood Hits	148
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

GRAP_HUMAN
NC score	0.105863 (rank : 858)	θ value	θ > 10 (rank : 1305)
Query Neighborhood Hits	1275	Target Neighborhood Hits	307	Shared Neighborhood Hits	68
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.105289 (rank : 859)	θ value	θ > 10 (rank : 1306)
Query Neighborhood Hits	1275	Target Neighborhood Hits	309	Shared Neighborhood Hits	66
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
NC score	0.102625 (rank : 860)	θ value	θ > 10 (rank : 1309)
Query Neighborhood Hits	1275	Target Neighborhood Hits	310	Shared Neighborhood Hits	65
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.102574 (rank : 861)	θ value	θ > 10 (rank : 1310)
Query Neighborhood Hits	1275	Target Neighborhood Hits	312	Shared Neighborhood Hits	65
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRAP2_HUMAN
NC score	0.102165 (rank : 862)	θ value	θ > 10 (rank : 1303)
Query Neighborhood Hits	1275	Target Neighborhood Hits	304	Shared Neighborhood Hits	65
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.100391 (rank : 863)	θ value	θ > 10 (rank : 1304)
Query Neighborhood Hits	1275	Target Neighborhood Hits	297	Shared Neighborhood Hits	62
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCK2_HUMAN
NC score	0.098211 (rank : 864)	θ value	θ > 10 (rank : 1339)
Query Neighborhood Hits	1275	Target Neighborhood Hits	310	Shared Neighborhood Hits	68
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.098179 (rank : 865)	θ value	θ > 10 (rank : 1338)
Query Neighborhood Hits	1275	Target Neighborhood Hits	312	Shared Neighborhood Hits	66
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH21B_MOUSE
NC score	0.097893 (rank : 866)	θ value	θ > 10 (rank : 1388)
Query Neighborhood Hits	1275	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

BUB1B_HUMAN
NC score	0.096357 (rank : 867)	θ value	θ > 10 (rank : 1280)
Query Neighborhood Hits	1275	Target Neighborhood Hits	208	Shared Neighborhood Hits	119
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1B_MOUSE
NC score	0.089359 (rank : 868)	θ value	θ > 10 (rank : 1281)
Query Neighborhood Hits	1275	Target Neighborhood Hits	202	Shared Neighborhood Hits	120
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

STAC_MOUSE
NC score	0.088889 (rank : 869)	θ value	θ > 10 (rank : 1408)
Query Neighborhood Hits	1275	Target Neighborhood Hits	268	Shared Neighborhood Hits	86
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC3_MOUSE
NC score	0.088634 (rank : 870)	θ value	θ > 10 (rank : 1406)
Query Neighborhood Hits	1275	Target Neighborhood Hits	232	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.088298 (rank : 871)	θ value	θ > 10 (rank : 1405)
Query Neighborhood Hits	1275	Target Neighborhood Hits	228	Shared Neighborhood Hits	73
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SRRM1_MOUSE
NC score	0.088016 (rank : 872)	θ value	0.125558 (rank : 881)
Query Neighborhood Hits	1275	Target Neighborhood Hits	966	Shared Neighborhood Hits	252
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SH21A_MOUSE
NC score	0.087444 (rank : 873)	θ value	θ > 10 (rank : 1386)
Query Neighborhood Hits	1275	Target Neighborhood Hits	89	Shared Neighborhood Hits	39
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
NC score	0.087366 (rank : 874)	θ value	θ > 10 (rank : 1387)
Query Neighborhood Hits	1275	Target Neighborhood Hits	101	Shared Neighborhood Hits	40
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

RASA1_HUMAN
NC score	0.082538 (rank : 875)	θ value	θ > 10 (rank : 1369)
Query Neighborhood Hits	1275	Target Neighborhood Hits	258	Shared Neighborhood Hits	66
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

STAC_HUMAN
NC score	0.082312 (rank : 876)	θ value	θ > 10 (rank : 1407)
Query Neighborhood Hits	1275	Target Neighborhood Hits	276	Shared Neighborhood Hits	85
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SH21A_HUMAN
NC score	0.081160 (rank : 877)	θ value	θ > 10 (rank : 1385)
Query Neighborhood Hits	1275	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

VAV3_HUMAN
NC score	0.080864 (rank : 878)	θ value	θ > 10 (rank : 1417)
Query Neighborhood Hits	1275	Target Neighborhood Hits	398	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.080707 (rank : 879)	θ value	θ > 10 (rank : 1418)
Query Neighborhood Hits	1275	Target Neighborhood Hits	404	Shared Neighborhood Hits	102
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

GRP3_HUMAN
NC score	0.080414 (rank : 880)	θ value	θ > 10 (rank : 1312)
Query Neighborhood Hits	1275	Target Neighborhood Hits	131	Shared Neighborhood Hits	45
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

VAV_HUMAN
NC score	0.078330 (rank : 881)	θ value	θ > 10 (rank : 1419)
Query Neighborhood Hits	1275	Target Neighborhood Hits	452	Shared Neighborhood Hits	100
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

SRRM2_MOUSE
NC score	0.078132 (rank : 882)	θ value	0.0148317 (rank : 842)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1470	Shared Neighborhood Hits	308
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

VAV2_HUMAN
NC score	0.075886 (rank : 883)	θ value	θ > 10 (rank : 1415)
Query Neighborhood Hits	1275	Target Neighborhood Hits	453	Shared Neighborhood Hits	100
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SRRM1_HUMAN
NC score	0.073835 (rank : 884)	θ value	8.99809 (rank : 1266)
Query Neighborhood Hits	1275	Target Neighborhood Hits	690	Shared Neighborhood Hits	207
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM2_HUMAN
NC score	0.073474 (rank : 885)	θ value	1.38821 (rank : 1027)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1296	Shared Neighborhood Hits	298
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

VAV2_MOUSE
NC score	0.072830 (rank : 886)	θ value	θ > 10 (rank : 1416)
Query Neighborhood Hits	1275	Target Neighborhood Hits	456	Shared Neighborhood Hits	98
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV_MOUSE
NC score	0.072829 (rank : 887)	θ value	θ > 10 (rank : 1420)
Query Neighborhood Hits	1275	Target Neighborhood Hits	430	Shared Neighborhood Hits	98
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

DAPP1_HUMAN
NC score	0.072684 (rank : 888)	θ value	θ > 10 (rank : 1292)
Query Neighborhood Hits	1275	Target Neighborhood Hits	227	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CRKL_MOUSE
NC score	0.071296 (rank : 889)	θ value	θ > 10 (rank : 1289)
Query Neighborhood Hits	1275	Target Neighborhood Hits	307	Shared Neighborhood Hits	63
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

DCC_MOUSE
NC score	0.070917 (rank : 890)	θ value	0.000270298 (rank : 790)
Query Neighborhood Hits	1275	Target Neighborhood Hits	896	Shared Neighborhood Hits	189
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

NEO1_HUMAN
NC score	0.070764 (rank : 891)	θ value	θ > 10 (rank : 1340)
Query Neighborhood Hits	1275	Target Neighborhood Hits	530	Shared Neighborhood Hits	106
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
NC score	0.070745 (rank : 892)	θ value	θ > 10 (rank : 1341)
Query Neighborhood Hits	1275	Target Neighborhood Hits	523	Shared Neighborhood Hits	107
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

DAPP1_MOUSE
NC score	0.070559 (rank : 893)	θ value	θ > 10 (rank : 1293)
Query Neighborhood Hits	1275	Target Neighborhood Hits	225	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CRKL_HUMAN
NC score	0.070348 (rank : 894)	θ value	θ > 10 (rank : 1288)
Query Neighborhood Hits	1275	Target Neighborhood Hits	313	Shared Neighborhood Hits	64
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

TARSH_HUMAN
NC score	0.068593 (rank : 895)	θ value	0.00869519 (rank : 835)
Query Neighborhood Hits	1275	Target Neighborhood Hits	768	Shared Neighborhood Hits	191
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

HSH2D_HUMAN
NC score	0.068203 (rank : 896)	θ value	θ > 10 (rank : 1314)
Query Neighborhood Hits	1275	Target Neighborhood Hits	159	Shared Neighborhood Hits	47
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

CHIN_MOUSE
NC score	0.068012 (rank : 897)	θ value	θ > 10 (rank : 1284)
Query Neighborhood Hits	1275	Target Neighborhood Hits	229	Shared Neighborhood Hits	68
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
NC score	0.067928 (rank : 898)	θ value	θ > 10 (rank : 1285)
Query Neighborhood Hits	1275	Target Neighborhood Hits	220	Shared Neighborhood Hits	66
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_HUMAN
NC score	0.067008 (rank : 899)	θ value	θ > 10 (rank : 1283)
Query Neighborhood Hits	1275	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

DGKD_HUMAN
NC score	0.066386 (rank : 900)	θ value	θ > 10 (rank : 1295)
Query Neighborhood Hits	1275	Target Neighborhood Hits	231	Shared Neighborhood Hits	76
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

MYOM1_HUMAN
NC score	0.066067 (rank : 901)	θ value	θ > 10 (rank : 1325)
Query Neighborhood Hits	1275	Target Neighborhood Hits	405	Shared Neighborhood Hits	103
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

P85B_MOUSE
NC score	0.065931 (rank : 902)	θ value	θ > 10 (rank : 1355)
Query Neighborhood Hits	1275	Target Neighborhood Hits	519	Shared Neighborhood Hits	92
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PDZD8_HUMAN
NC score	0.065919 (rank : 903)	θ value	θ > 10 (rank : 1358)
Query Neighborhood Hits	1275	Target Neighborhood Hits	185	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

DCC_HUMAN
NC score	0.065652 (rank : 904)	θ value	θ > 10 (rank : 1294)
Query Neighborhood Hits	1275	Target Neighborhood Hits	583	Shared Neighborhood Hits	117
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

SHE_MOUSE
NC score	0.065487 (rank : 905)	θ value	θ > 10 (rank : 1398)
Query Neighborhood Hits	1275	Target Neighborhood Hits	169	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_HUMAN
NC score	0.065335 (rank : 906)	θ value	θ > 10 (rank : 1397)
Query Neighborhood Hits	1275	Target Neighborhood Hits	164	Shared Neighborhood Hits	50
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

FGRL1_MOUSE
NC score	0.064994 (rank : 907)	θ value	θ > 10 (rank : 1302)
Query Neighborhood Hits	1275	Target Neighborhood Hits	325	Shared Neighborhood Hits	51
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

NACAM_MOUSE
NC score	0.064658 (rank : 908)	θ value	4.92598e-06 (rank : 744)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1866	Shared Neighborhood Hits	364
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

MYOM1_MOUSE
NC score	0.064300 (rank : 909)	θ value	θ > 10 (rank : 1326)
Query Neighborhood Hits	1275	Target Neighborhood Hits	415	Shared Neighborhood Hits	102
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

P85B_HUMAN
NC score	0.064061 (rank : 910)	θ value	θ > 10 (rank : 1354)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	102
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P55G_MOUSE
NC score	0.063581 (rank : 911)	θ value	θ > 10 (rank : 1351)
Query Neighborhood Hits	1275	Target Neighborhood Hits	401	Shared Neighborhood Hits	84
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

FGRL1_HUMAN
NC score	0.063049 (rank : 912)	θ value	θ > 10 (rank : 1301)
Query Neighborhood Hits	1275	Target Neighborhood Hits	335	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

GRB14_MOUSE
NC score	0.063017 (rank : 913)	θ value	θ > 10 (rank : 1308)
Query Neighborhood Hits	1275	Target Neighborhood Hits	149	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

PLCG1_MOUSE
NC score	0.062812 (rank : 914)	θ value	θ > 10 (rank : 1362)
Query Neighborhood Hits	1275	Target Neighborhood Hits	314	Shared Neighborhood Hits	70
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DSCL1_HUMAN
NC score	0.062644 (rank : 915)	θ value	θ > 10 (rank : 1299)
Query Neighborhood Hits	1275	Target Neighborhood Hits	589	Shared Neighborhood Hits	127
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

PLCG1_HUMAN
NC score	0.062525 (rank : 916)	θ value	θ > 10 (rank : 1361)
Query Neighborhood Hits	1275	Target Neighborhood Hits	293	Shared Neighborhood Hits	68
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RASF1_MOUSE
NC score	0.062485 (rank : 917)	θ value	θ > 10 (rank : 1371)
Query Neighborhood Hits	1275	Target Neighborhood Hits	74	Shared Neighborhood Hits	34
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

P55G_HUMAN
NC score	0.062480 (rank : 918)	θ value	θ > 10 (rank : 1350)
Query Neighborhood Hits	1275	Target Neighborhood Hits	451	Shared Neighborhood Hits	81
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SH24A_HUMAN
NC score	0.062295 (rank : 919)	θ value	θ > 10 (rank : 1389)
Query Neighborhood Hits	1275	Target Neighborhood Hits	455	Shared Neighborhood Hits	90
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SDK1_HUMAN
NC score	0.061622 (rank : 920)	θ value	θ > 10 (rank : 1381)
Query Neighborhood Hits	1275	Target Neighborhood Hits	511	Shared Neighborhood Hits	104
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

PLCG2_HUMAN
NC score	0.061308 (rank : 921)	θ value	θ > 10 (rank : 1363)
Query Neighborhood Hits	1275	Target Neighborhood Hits	280	Shared Neighborhood Hits	60
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PACE1_MOUSE
NC score	0.060963 (rank : 922)	θ value	θ > 10 (rank : 1357)
Query Neighborhood Hits	1275	Target Neighborhood Hits	92	Shared Neighborhood Hits	58
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

UN13A_HUMAN
NC score	0.060332 (rank : 923)	θ value	θ > 10 (rank : 1412)
Query Neighborhood Hits	1275	Target Neighborhood Hits	285	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

DGKH_HUMAN
NC score	0.060175 (rank : 924)	θ value	θ > 10 (rank : 1296)
Query Neighborhood Hits	1275	Target Neighborhood Hits	255	Shared Neighborhood Hits	69
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

SDK1_MOUSE
NC score	0.059926 (rank : 925)	θ value	θ > 10 (rank : 1382)
Query Neighborhood Hits	1275	Target Neighborhood Hits	495	Shared Neighborhood Hits	100
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

CRK_HUMAN
NC score	0.059882 (rank : 926)	θ value	θ > 10 (rank : 1290)
Query Neighborhood Hits	1275	Target Neighborhood Hits	308	Shared Neighborhood Hits	64
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SDK2_HUMAN
NC score	0.059818 (rank : 927)	θ value	θ > 10 (rank : 1383)
Query Neighborhood Hits	1275	Target Neighborhood Hits	495	Shared Neighborhood Hits	101
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

MYOM2_HUMAN
NC score	0.059737 (rank : 928)	θ value	θ > 10 (rank : 1327)
Query Neighborhood Hits	1275	Target Neighborhood Hits	341	Shared Neighborhood Hits	76
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

PACE1_HUMAN
NC score	0.059730 (rank : 929)	θ value	θ > 10 (rank : 1356)
Query Neighborhood Hits	1275	Target Neighborhood Hits	74	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

NCAM2_MOUSE
NC score	0.059670 (rank : 930)	θ value	θ > 10 (rank : 1337)
Query Neighborhood Hits	1275	Target Neighborhood Hits	472	Shared Neighborhood Hits	87
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

DSCAM_HUMAN
NC score	0.059418 (rank : 931)	θ value	θ > 10 (rank : 1298)
Query Neighborhood Hits	1275	Target Neighborhood Hits	524	Shared Neighborhood Hits	97
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

L1CAM_HUMAN
NC score	0.058885 (rank : 932)	θ value	θ > 10 (rank : 1320)
Query Neighborhood Hits	1275	Target Neighborhood Hits	457	Shared Neighborhood Hits	96
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PGFRL_MOUSE
NC score	0.058881 (rank : 933)	θ value	θ > 10 (rank : 1360)
Query Neighborhood Hits	1275	Target Neighborhood Hits	106	Shared Neighborhood Hits	30
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

MDC1_HUMAN
NC score	0.058846 (rank : 934)	θ value	0.00228821 (rank : 822)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1446	Shared Neighborhood Hits	259
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CRK_MOUSE
NC score	0.058798 (rank : 935)	θ value	θ > 10 (rank : 1291)
Query Neighborhood Hits	1275	Target Neighborhood Hits	314	Shared Neighborhood Hits	66
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

MDC1_MOUSE
NC score	0.058762 (rank : 936)	θ value	0.00134147 (rank : 814)
Query Neighborhood Hits	1275	Target Neighborhood Hits	998	Shared Neighborhood Hits	220
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PGFRL_HUMAN
NC score	0.058531 (rank : 937)	θ value	θ > 10 (rank : 1359)
Query Neighborhood Hits	1275	Target Neighborhood Hits	115	Shared Neighborhood Hits	31
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

ROBO1_MOUSE
NC score	0.058335 (rank : 938)	θ value	θ > 10 (rank : 1374)
Query Neighborhood Hits	1275	Target Neighborhood Hits	559	Shared Neighborhood Hits	121
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

SDK2_MOUSE
NC score	0.058122 (rank : 939)	θ value	θ > 10 (rank : 1384)
Query Neighborhood Hits	1275	Target Neighborhood Hits	480	Shared Neighborhood Hits	97
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

GRB14_HUMAN
NC score	0.057981 (rank : 940)	θ value	θ > 10 (rank : 1307)
Query Neighborhood Hits	1275	Target Neighborhood Hits	137	Shared Neighborhood Hits	42
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

NCAM2_HUMAN
NC score	0.057714 (rank : 941)	θ value	θ > 10 (rank : 1336)
Query Neighborhood Hits	1275	Target Neighborhood Hits	441	Shared Neighborhood Hits	84
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

MYPC3_MOUSE
NC score	0.057590 (rank : 942)	θ value	θ > 10 (rank : 1331)
Query Neighborhood Hits	1275	Target Neighborhood Hits	310	Shared Neighborhood Hits	71
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

ROBO1_HUMAN
NC score	0.057444 (rank : 943)	θ value	θ > 10 (rank : 1373)
Query Neighborhood Hits	1275	Target Neighborhood Hits	529	Shared Neighborhood Hits	107
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

APS_HUMAN
NC score	0.057404 (rank : 944)	θ value	θ > 10 (rank : 1278)
Query Neighborhood Hits	1275	Target Neighborhood Hits	162	Shared Neighborhood Hits	57
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

NFASC_HUMAN
NC score	0.057378 (rank : 945)	θ value	θ > 10 (rank : 1342)
Query Neighborhood Hits	1275	Target Neighborhood Hits	497	Shared Neighborhood Hits	109
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

UN13B_HUMAN
NC score	0.057283 (rank : 946)	θ value	θ > 10 (rank : 1413)
Query Neighborhood Hits	1275	Target Neighborhood Hits	217	Shared Neighborhood Hits	47
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

MYPN_MOUSE
NC score	0.057013 (rank : 947)	θ value	8.99809 (rank : 1255)
Query Neighborhood Hits	1275	Target Neighborhood Hits	421	Shared Neighborhood Hits	92
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NRCAM_HUMAN
NC score	0.056898 (rank : 948)	θ value	θ > 10 (rank : 1348)
Query Neighborhood Hits	1275	Target Neighborhood Hits	439	Shared Neighborhood Hits	90
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

ROBO3_HUMAN
NC score	0.056593 (rank : 949)	θ value	θ > 10 (rank : 1377)
Query Neighborhood Hits	1275	Target Neighborhood Hits	570	Shared Neighborhood Hits	121
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

BSN_HUMAN
NC score	0.056414 (rank : 950)	θ value	0.0252991 (rank : 849)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1537	Shared Neighborhood Hits	308
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

ROBO2_MOUSE
NC score	0.056207 (rank : 951)	θ value	θ > 10 (rank : 1376)
Query Neighborhood Hits	1275	Target Neighborhood Hits	504	Shared Neighborhood Hits	91
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

NCA11_MOUSE
NC score	0.056004 (rank : 952)	θ value	θ > 10 (rank : 1334)
Query Neighborhood Hits	1275	Target Neighborhood Hits	661	Shared Neighborhood Hits	154
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

ROBO2_HUMAN
NC score	0.055997 (rank : 953)	θ value	θ > 10 (rank : 1375)
Query Neighborhood Hits	1275	Target Neighborhood Hits	479	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

MYPN_HUMAN
NC score	0.055934 (rank : 954)	θ value	θ > 10 (rank : 1332)
Query Neighborhood Hits	1275	Target Neighborhood Hits	418	Shared Neighborhood Hits	90
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

L1CAM_MOUSE
NC score	0.055670 (rank : 955)	θ value	θ > 10 (rank : 1321)
Query Neighborhood Hits	1275	Target Neighborhood Hits	457	Shared Neighborhood Hits	95
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

TARA_HUMAN
NC score	0.055659 (rank : 956)	θ value	9.29e-05 (rank : 778)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1626	Shared Neighborhood Hits	265
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

NPHP1_MOUSE
NC score	0.055409 (rank : 957)	θ value	θ > 10 (rank : 1345)
Query Neighborhood Hits	1275	Target Neighborhood Hits	267	Shared Neighborhood Hits	49
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

UN13B_MOUSE
NC score	0.055257 (rank : 958)	θ value	θ > 10 (rank : 1414)
Query Neighborhood Hits	1275	Target Neighborhood Hits	210	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

NRCAM_MOUSE
NC score	0.054957 (rank : 959)	θ value	θ > 10 (rank : 1349)
Query Neighborhood Hits	1275	Target Neighborhood Hits	432	Shared Neighborhood Hits	89
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

MYPC3_HUMAN
NC score	0.054568 (rank : 960)	θ value	θ > 10 (rank : 1330)
Query Neighborhood Hits	1275	Target Neighborhood Hits	318	Shared Neighborhood Hits	73
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

SHC1_HUMAN
NC score	0.054487 (rank : 961)	θ value	θ > 10 (rank : 1392)
Query Neighborhood Hits	1275	Target Neighborhood Hits	170	Shared Neighborhood Hits	56
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

DGKQ_HUMAN
NC score	0.054481 (rank : 962)	θ value	θ > 10 (rank : 1297)
Query Neighborhood Hits	1275	Target Neighborhood Hits	131	Shared Neighborhood Hits	38
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

GRB7_MOUSE
NC score	0.054469 (rank : 963)	θ value	θ > 10 (rank : 1311)
Query Neighborhood Hits	1275	Target Neighborhood Hits	157	Shared Neighborhood Hits	51
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

SHC2_HUMAN
NC score	0.054293 (rank : 964)	θ value	θ > 10 (rank : 1394)
Query Neighborhood Hits	1275	Target Neighborhood Hits	170	Shared Neighborhood Hits	55
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SPN90_HUMAN
NC score	0.054262 (rank : 965)	θ value	θ > 10 (rank : 1403)
Query Neighborhood Hits	1275	Target Neighborhood Hits	157	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

NIPBL_HUMAN
NC score	0.054225 (rank : 966)	θ value	0.00102713 (rank : 811)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1311	Shared Neighborhood Hits	207
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NPHP1_HUMAN
NC score	0.054120 (rank : 967)	θ value	θ > 10 (rank : 1344)
Query Neighborhood Hits	1275	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SHB_MOUSE
NC score	0.053845 (rank : 968)	θ value	θ > 10 (rank : 1391)
Query Neighborhood Hits	1275	Target Neighborhood Hits	137	Shared Neighborhood Hits	48
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_MOUSE
NC score	0.053781 (rank : 969)	θ value	θ > 10 (rank : 1393)
Query Neighborhood Hits	1275	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

CHIO_MOUSE
NC score	0.053643 (rank : 970)	θ value	θ > 10 (rank : 1286)
Query Neighborhood Hits	1275	Target Neighborhood Hits	130	Shared Neighborhood Hits	40
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

LNK_HUMAN
NC score	0.053277 (rank : 971)	θ value	θ > 10 (rank : 1322)
Query Neighborhood Hits	1275	Target Neighborhood Hits	151	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ROBO3_MOUSE
NC score	0.053129 (rank : 972)	θ value	θ > 10 (rank : 1378)
Query Neighborhood Hits	1275	Target Neighborhood Hits	524	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

TGON2_HUMAN
NC score	0.053006 (rank : 973)	θ value	0.00509761 (rank : 829)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1037	Shared Neighborhood Hits	195
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

P85A_HUMAN
NC score	0.052846 (rank : 974)	θ value	θ > 10 (rank : 1352)
Query Neighborhood Hits	1275	Target Neighborhood Hits	479	Shared Neighborhood Hits	85
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SFRIP_HUMAN
NC score	0.052833 (rank : 975)	θ value	0.00869519 (rank : 834)
Query Neighborhood Hits	1275	Target Neighborhood Hits	530	Shared Neighborhood Hits	125
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

CNTN5_HUMAN
NC score	0.052795 (rank : 976)	θ value	θ > 10 (rank : 1287)
Query Neighborhood Hits	1275	Target Neighborhood Hits	446	Shared Neighborhood Hits	88
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

MYOTI_HUMAN
NC score	0.052747 (rank : 977)	θ value	θ > 10 (rank : 1328)
Query Neighborhood Hits	1275	Target Neighborhood Hits	292	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

NCA11_HUMAN
NC score	0.052619 (rank : 978)	θ value	θ > 10 (rank : 1333)
Query Neighborhood Hits	1275	Target Neighborhood Hits	443	Shared Neighborhood Hits	76
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

BSN_MOUSE
NC score	0.052514 (rank : 979)	θ value	1.38821 (rank : 1013)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2057	Shared Neighborhood Hits	351
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

PRB4S_HUMAN
NC score	0.052490 (rank : 980)	θ value	θ > 10 (rank : 1364)
Query Neighborhood Hits	1275	Target Neighborhood Hits	330	Shared Neighborhood Hits	118
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

MUC7_HUMAN
NC score	0.052359 (rank : 981)	θ value	θ > 10 (rank : 1324)
Query Neighborhood Hits	1275	Target Neighborhood Hits	538	Shared Neighborhood Hits	180
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NFASC_MOUSE
NC score	0.052211 (rank : 982)	θ value	θ > 10 (rank : 1343)
Query Neighborhood Hits	1275	Target Neighborhood Hits	475	Shared Neighborhood Hits	101
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

NCA12_HUMAN
NC score	0.052101 (rank : 983)	θ value	θ > 10 (rank : 1335)
Query Neighborhood Hits	1275	Target Neighborhood Hits	437	Shared Neighborhood Hits	75
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

P85A_MOUSE
NC score	0.051891 (rank : 984)	θ value	θ > 10 (rank : 1353)
Query Neighborhood Hits	1275	Target Neighborhood Hits	435	Shared Neighborhood Hits	84
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SPN90_MOUSE
NC score	0.051716 (rank : 985)	θ value	θ > 10 (rank : 1404)
Query Neighborhood Hits	1275	Target Neighborhood Hits	157	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SHB_HUMAN
NC score	0.051693 (rank : 986)	θ value	θ > 10 (rank : 1390)
Query Neighborhood Hits	1275	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_MOUSE
NC score	0.051294 (rank : 987)	θ value	θ > 10 (rank : 1396)
Query Neighborhood Hits	1275	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

RASF1_HUMAN
NC score	0.051098 (rank : 988)	θ value	θ > 10 (rank : 1370)
Query Neighborhood Hits	1275	Target Neighborhood Hits	62	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

BOC_HUMAN
NC score	0.050810 (rank : 989)	θ value	θ > 10 (rank : 1279)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	94
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

ITSN1_MOUSE
NC score	0.050653 (rank : 990)	θ value	1.81305 (rank : 1041)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1669	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NCOR2_HUMAN
NC score	0.050520 (rank : 991)	θ value	0.62314 (rank : 960)
Query Neighborhood Hits	1275	Target Neighborhood Hits	870	Shared Neighborhood Hits	209
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

PTPRD_HUMAN
NC score	0.050299 (rank : 992)	θ value	θ > 10 (rank : 1367)
Query Neighborhood Hits	1275	Target Neighborhood Hits	485	Shared Neighborhood Hits	93
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

IASPP_HUMAN
NC score	0.050258 (rank : 993)	θ value	1.81305 (rank : 1040)
Query Neighborhood Hits	1275	Target Neighborhood Hits	688	Shared Neighborhood Hits	159
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SHD_HUMAN
NC score	0.050222 (rank : 994)	θ value	θ > 10 (rank : 1395)
Query Neighborhood Hits	1275	Target Neighborhood Hits	204	Shared Neighborhood Hits	53
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

MYOTI_MOUSE
NC score	0.050204 (rank : 995)	θ value	θ > 10 (rank : 1329)
Query Neighborhood Hits	1275	Target Neighborhood Hits	297	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

ES8L3_HUMAN
NC score	0.050176 (rank : 996)	θ value	θ > 10 (rank : 1300)
Query Neighborhood Hits	1275	Target Neighborhood Hits	206	Shared Neighborhood Hits	58
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PUNC_HUMAN
NC score	0.050119 (rank : 997)	θ value	θ > 10 (rank : 1368)
Query Neighborhood Hits	1275	Target Neighborhood Hits	449	Shared Neighborhood Hits	74
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

LCP2_HUMAN
NC score	0.049998 (rank : 998)	θ value	0.47712 (rank : 934)
Query Neighborhood Hits	1275	Target Neighborhood Hits	531	Shared Neighborhood Hits	148
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

PCLO_HUMAN
NC score	0.049742 (rank : 999)	θ value	0.813845 (rank : 980)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2046	Shared Neighborhood Hits	364
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

SON_HUMAN
NC score	0.049446 (rank : 1000)	θ value	0.00175202 (rank : 819)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1568	Shared Neighborhood Hits	296
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

NPBL_MOUSE
NC score	0.049046 (rank : 1001)	θ value	0.000602161 (rank : 802)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1041	Shared Neighborhood Hits	177
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

CN155_HUMAN
NC score	0.048942 (rank : 1002)	θ value	0.0431538 (rank : 856)
Query Neighborhood Hits	1275	Target Neighborhood Hits	385	Shared Neighborhood Hits	122
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

IASPP_MOUSE
NC score	0.047923 (rank : 1003)	θ value	0.0431538 (rank : 858)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1024	Shared Neighborhood Hits	188
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NOLC1_HUMAN
NC score	0.047884 (rank : 1004)	θ value	0.0193708 (rank : 844)
Query Neighborhood Hits	1275	Target Neighborhood Hits	452	Shared Neighborhood Hits	125
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NCOA6_MOUSE
NC score	0.047867 (rank : 1005)	θ value	0.21417 (rank : 894)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1076	Shared Neighborhood Hits	235
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

RBBP6_MOUSE
NC score	0.047218 (rank : 1006)	θ value	0.125558 (rank : 879)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1014	Shared Neighborhood Hits	189
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

PCLO_MOUSE
NC score	0.047094 (rank : 1007)	θ value	5.27518 (rank : 1172)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2275	Shared Neighborhood Hits	378
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PCQAP_HUMAN
NC score	0.047029 (rank : 1008)	θ value	1.81305 (rank : 1047)
Query Neighborhood Hits	1275	Target Neighborhood Hits	549	Shared Neighborhood Hits	156
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

ASPP1_MOUSE
NC score	0.045491 (rank : 1009)	θ value	0.125558 (rank : 875)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1244	Shared Neighborhood Hits	226
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

TCOF_MOUSE
NC score	0.044115 (rank : 1010)	θ value	6.88961 (rank : 1231)
Query Neighborhood Hits	1275	Target Neighborhood Hits	471	Shared Neighborhood Hits	130
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

SON_MOUSE
NC score	0.044063 (rank : 1011)	θ value	0.0148317 (rank : 841)
Query Neighborhood Hits	1275	Target Neighborhood Hits	957	Shared Neighborhood Hits	215
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

CK024_HUMAN
NC score	0.043776 (rank : 1012)	θ value	0.0736092 (rank : 868)
Query Neighborhood Hits	1275	Target Neighborhood Hits	408	Shared Neighborhood Hits	111
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CSKI1_MOUSE
NC score	0.042873 (rank : 1013)	θ value	4.03905 (rank : 1113)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1031	Shared Neighborhood Hits	224
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NCOA6_HUMAN
NC score	0.042772 (rank : 1014)	θ value	0.47712 (rank : 936)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1202	Shared Neighborhood Hits	254
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

IWS1_HUMAN
NC score	0.042320 (rank : 1015)	θ value	0.00102713 (rank : 809)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1241	Shared Neighborhood Hits	201
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NCOR2_MOUSE
NC score	0.041821 (rank : 1016)	θ value	2.36792 (rank : 1073)
Query Neighborhood Hits	1275	Target Neighborhood Hits	790	Shared Neighborhood Hits	190
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

ASPP2_HUMAN
NC score	0.041727 (rank : 1017)	θ value	6.88961 (rank : 1190)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1156	Shared Neighborhood Hits	204
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAT2_HUMAN
NC score	0.041458 (rank : 1018)	θ value	1.38821 (rank : 1011)
Query Neighborhood Hits	1275	Target Neighborhood Hits	931	Shared Neighborhood Hits	221
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

MINT_MOUSE
NC score	0.041155 (rank : 1019)	θ value	0.0148317 (rank : 840)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1514	Shared Neighborhood Hits	276
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

TXND2_HUMAN
NC score	0.040968 (rank : 1020)	θ value	1.38821 (rank : 1028)
Query Neighborhood Hits	1275	Target Neighborhood Hits	793	Shared Neighborhood Hits	163
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

RGS3_MOUSE
NC score	0.040655 (rank : 1021)	θ value	0.000602161 (rank : 803)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1621	Shared Neighborhood Hits	286
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

MAP1A_HUMAN
NC score	0.040476 (rank : 1022)	θ value	6.88961 (rank : 1211)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1626	Shared Neighborhood Hits	261
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NFH_MOUSE
NC score	0.039660 (rank : 1023)	θ value	0.00509761 (rank : 828)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2247	Shared Neighborhood Hits	343
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

RGS3_HUMAN
NC score	0.039475 (rank : 1024)	θ value	0.00228821 (rank : 823)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1375	Shared Neighborhood Hits	225
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TARA_MOUSE
NC score	0.039295 (rank : 1025)	θ value	0.813845 (rank : 990)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1133	Shared Neighborhood Hits	208
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ENAH_HUMAN
NC score	0.038964 (rank : 1026)	θ value	8.99809 (rank : 1248)
Query Neighborhood Hits	1275	Target Neighborhood Hits	784	Shared Neighborhood Hits	180
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

SH22A_MOUSE
NC score	0.038796 (rank : 1027)	θ value	2.36792 (rank : 1081)
Query Neighborhood Hits	1275	Target Neighborhood Hits	179	Shared Neighborhood Hits	44
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

OGFR_HUMAN
NC score	0.038656 (rank : 1028)	θ value	1.06291 (rank : 1002)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1582	Shared Neighborhood Hits	250
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

WIRE_HUMAN
NC score	0.038563 (rank : 1029)	θ value	4.03905 (rank : 1138)
Query Neighborhood Hits	1275	Target Neighborhood Hits	329	Shared Neighborhood Hits	132
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

TENS1_HUMAN
NC score	0.038516 (rank : 1030)	θ value	0.47712 (rank : 941)
Query Neighborhood Hits	1275	Target Neighborhood Hits	400	Shared Neighborhood Hits	99
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

CCD45_MOUSE
NC score	0.038473 (rank : 1031)	θ value	0.163984 (rank : 884)
Query Neighborhood Hits	1275	Target Neighborhood Hits	663	Shared Neighborhood Hits	96
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

MLL2_HUMAN
NC score	0.038371 (rank : 1032)	θ value	3.0926 (rank : 1099)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1788	Shared Neighborhood Hits	315
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

RBBP6_HUMAN
NC score	0.037895 (rank : 1033)	θ value	0.0193708 (rank : 846)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1135	Shared Neighborhood Hits	188
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

LAD1_MOUSE
NC score	0.037658 (rank : 1034)	θ value	4.03905 (rank : 1121)
Query Neighborhood Hits	1275	Target Neighborhood Hits	391	Shared Neighborhood Hits	115
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

CCD55_MOUSE
NC score	0.037542 (rank : 1035)	θ value	0.279714 (rank : 900)
Query Neighborhood Hits	1275	Target Neighborhood Hits	519	Shared Neighborhood Hits	90
SwissProt Accessions	Q5NCR9	Gene names	Ccdc55
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 55.

ANK2_HUMAN
NC score	0.037100 (rank : 1036)	θ value	0.00035302 (rank : 793)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1615	Shared Neighborhood Hits	280
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

IWS1_MOUSE
NC score	0.035743 (rank : 1037)	θ value	0.0252991 (rank : 851)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1258	Shared Neighborhood Hits	197
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

YLPM1_HUMAN
NC score	0.035372 (rank : 1038)	θ value	5.27518 (rank : 1185)
Query Neighborhood Hits	1275	Target Neighborhood Hits	670	Shared Neighborhood Hits	183
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

PLCB4_HUMAN
NC score	0.035094 (rank : 1039)	θ value	1.06291 (rank : 1004)
Query Neighborhood Hits	1275	Target Neighborhood Hits	658	Shared Neighborhood Hits	104
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

BCAR1_MOUSE
NC score	0.034769 (rank : 1040)	θ value	0.0193708 (rank : 843)
Query Neighborhood Hits	1275	Target Neighborhood Hits	438	Shared Neighborhood Hits	118
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_HUMAN
NC score	0.034489 (rank : 1041)	θ value	0.00134147 (rank : 813)
Query Neighborhood Hits	1275	Target Neighborhood Hits	554	Shared Neighborhood Hits	126
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

WIRE_MOUSE
NC score	0.034132 (rank : 1042)	θ value	3.0926 (rank : 1107)
Query Neighborhood Hits	1275	Target Neighborhood Hits	310	Shared Neighborhood Hits	115
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

MBB1A_HUMAN
NC score	0.033869 (rank : 1043)	θ value	0.62314 (rank : 958)
Query Neighborhood Hits	1275	Target Neighborhood Hits	665	Shared Neighborhood Hits	138
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

PRRT3_HUMAN
NC score	0.033383 (rank : 1044)	θ value	0.365318 (rank : 924)
Query Neighborhood Hits	1275	Target Neighborhood Hits	998	Shared Neighborhood Hits	186
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

MUC1_HUMAN
NC score	0.033108 (rank : 1045)	θ value	0.00175202 (rank : 818)
Query Neighborhood Hits	1275	Target Neighborhood Hits	975	Shared Neighborhood Hits	182
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

EP300_HUMAN
NC score	0.033048 (rank : 1046)	θ value	0.0563607 (rank : 861)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	206
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

FILA_HUMAN
NC score	0.032990 (rank : 1047)	θ value	0.163984 (rank : 887)
Query Neighborhood Hits	1275	Target Neighborhood Hits	685	Shared Neighborhood Hits	108
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

SELPL_MOUSE
NC score	0.032786 (rank : 1048)	θ value	0.0193708 (rank : 847)
Query Neighborhood Hits	1275	Target Neighborhood Hits	588	Shared Neighborhood Hits	134
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

CBP_HUMAN
NC score	0.032565 (rank : 1049)	θ value	0.62314 (rank : 948)
Query Neighborhood Hits	1275	Target Neighborhood Hits	941	Shared Neighborhood Hits	223
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

TCOF_HUMAN
NC score	0.032487 (rank : 1050)	θ value	1.06291 (rank : 1008)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	121
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TXLNB_HUMAN
NC score	0.031897 (rank : 1051)	θ value	0.21417 (rank : 899)
Query Neighborhood Hits	1275	Target Neighborhood Hits	912	Shared Neighborhood Hits	151
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

PELP1_MOUSE
NC score	0.031069 (rank : 1052)	θ value	1.81305 (rank : 1048)
Query Neighborhood Hits	1275	Target Neighborhood Hits	709	Shared Neighborhood Hits	158
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

KI67_HUMAN
NC score	0.031063 (rank : 1053)	θ value	5.27518 (rank : 1164)
Query Neighborhood Hits	1275	Target Neighborhood Hits	581	Shared Neighborhood Hits	120
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

ATX2L_HUMAN
NC score	0.031027 (rank : 1054)	θ value	4.03905 (rank : 1110)
Query Neighborhood Hits	1275	Target Neighborhood Hits	443	Shared Neighborhood Hits	140
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

TXND2_MOUSE
NC score	0.030915 (rank : 1055)	θ value	0.00509761 (rank : 830)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	116
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

BRD4_HUMAN
NC score	0.030638 (rank : 1056)	θ value	8.99809 (rank : 1242)
Query Neighborhood Hits	1275	Target Neighborhood Hits	851	Shared Neighborhood Hits	239
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CRTC1_HUMAN
NC score	0.030555 (rank : 1057)	θ value	0.0563607 (rank : 860)
Query Neighborhood Hits	1275	Target Neighborhood Hits	319	Shared Neighborhood Hits	111
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

CRSP2_HUMAN
NC score	0.029990 (rank : 1058)	θ value	0.00509761 (rank : 827)
Query Neighborhood Hits	1275	Target Neighborhood Hits	380	Shared Neighborhood Hits	87
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

CIC_HUMAN
NC score	0.029704 (rank : 1059)	θ value	1.06291 (rank : 996)
Query Neighborhood Hits	1275	Target Neighborhood Hits	992	Shared Neighborhood Hits	222
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

FA47A_HUMAN
NC score	0.029589 (rank : 1060)	θ value	4.03905 (rank : 1116)
Query Neighborhood Hits	1275	Target Neighborhood Hits	451	Shared Neighborhood Hits	120
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

K0586_HUMAN
NC score	0.029540 (rank : 1061)	θ value	0.813845 (rank : 974)
Query Neighborhood Hits	1275	Target Neighborhood Hits	311	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

PGBM_MOUSE
NC score	0.029534 (rank : 1062)	θ value	3.0926 (rank : 1103)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1073	Shared Neighborhood Hits	104
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

SYNJ1_MOUSE
NC score	0.029172 (rank : 1063)	θ value	0.0961366 (rank : 874)
Query Neighborhood Hits	1275	Target Neighborhood Hits	516	Shared Neighborhood Hits	159
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

LAD1_HUMAN
NC score	0.028958 (rank : 1064)	θ value	1.81305 (rank : 1043)
Query Neighborhood Hits	1275	Target Neighborhood Hits	441	Shared Neighborhood Hits	114
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

MLL3_HUMAN
NC score	0.028945 (rank : 1065)	θ value	0.0961366 (rank : 872)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1644	Shared Neighborhood Hits	271
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

TTC16_HUMAN
NC score	0.028525 (rank : 1066)	θ value	0.0193708 (rank : 848)
Query Neighborhood Hits	1275	Target Neighborhood Hits	417	Shared Neighborhood Hits	85
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

ATX2L_MOUSE
NC score	0.028079 (rank : 1067)	θ value	3.0926 (rank : 1091)
Query Neighborhood Hits	1275	Target Neighborhood Hits	401	Shared Neighborhood Hits	120
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

SFR15_HUMAN
NC score	0.027930 (rank : 1068)	θ value	6.88961 (rank : 1227)
Query Neighborhood Hits	1275	Target Neighborhood Hits	368	Shared Neighborhood Hits	114
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

MYO9B_HUMAN
NC score	0.027891 (rank : 1069)	θ value	3.0926 (rank : 1100)
Query Neighborhood Hits	1275	Target Neighborhood Hits	641	Shared Neighborhood Hits	149
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

C8AP2_HUMAN
NC score	0.027531 (rank : 1070)	θ value	1.38821 (rank : 1014)
Query Neighborhood Hits	1275	Target Neighborhood Hits	548	Shared Neighborhood Hits	102
SwissProt Accessions	Q9UKL3, Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1, Q9Y563	Gene names	CASP8AP2, FLASH, KIAA1315, RIP25
Domain Architecture	No domain graphic available
Description	CASP8-associated protein 2 (FLICE-associated huge protein).

CI039_HUMAN
NC score	0.027375 (rank : 1071)	θ value	0.365318 (rank : 917)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1171	Shared Neighborhood Hits	129
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

EMSY_MOUSE
NC score	0.027260 (rank : 1072)	θ value	0.0252991 (rank : 850)
Query Neighborhood Hits	1275	Target Neighborhood Hits	294	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

CO039_MOUSE
NC score	0.027084 (rank : 1073)	θ value	3.0926 (rank : 1093)
Query Neighborhood Hits	1275	Target Neighborhood Hits	445	Shared Neighborhood Hits	128
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

AKAP2_MOUSE
NC score	0.026722 (rank : 1074)	θ value	2.36792 (rank : 1057)
Query Neighborhood Hits	1275	Target Neighborhood Hits	385	Shared Neighborhood Hits	89
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

ELOA1_HUMAN
NC score	0.026660 (rank : 1075)	θ value	2.36792 (rank : 1065)
Query Neighborhood Hits	1275	Target Neighborhood Hits	388	Shared Neighborhood Hits	74
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

CEP35_HUMAN
NC score	0.026616 (rank : 1076)	θ value	6.88961 (rank : 1194)
Query Neighborhood Hits	1275	Target Neighborhood Hits	811	Shared Neighborhood Hits	129
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

SNPC4_HUMAN
NC score	0.026077 (rank : 1077)	θ value	0.47712 (rank : 939)
Query Neighborhood Hits	1275	Target Neighborhood Hits	589	Shared Neighborhood Hits	128
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

DOT1L_HUMAN
NC score	0.025940 (rank : 1078)	θ value	4.03905 (rank : 1115)
Query Neighborhood Hits	1275	Target Neighborhood Hits	660	Shared Neighborhood Hits	142
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

ANR11_HUMAN
NC score	0.025112 (rank : 1079)	θ value	1.06291 (rank : 994)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1289	Shared Neighborhood Hits	192
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

SETBP_HUMAN
NC score	0.025046 (rank : 1080)	θ value	0.0563607 (rank : 864)
Query Neighborhood Hits	1275	Target Neighborhood Hits	305	Shared Neighborhood Hits	85
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

CIC_MOUSE
NC score	0.025030 (rank : 1081)	θ value	0.125558 (rank : 877)
Query Neighborhood Hits	1275	Target Neighborhood Hits	742	Shared Neighborhood Hits	176
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

LPP_HUMAN
NC score	0.024927 (rank : 1082)	θ value	0.0148317 (rank : 839)
Query Neighborhood Hits	1275	Target Neighborhood Hits	775	Shared Neighborhood Hits	147
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

DMP1_HUMAN
NC score	0.024542 (rank : 1083)	θ value	8.99809 (rank : 1246)
Query Neighborhood Hits	1275	Target Neighborhood Hits	491	Shared Neighborhood Hits	84
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

BAZ2A_MOUSE
NC score	0.024383 (rank : 1084)	θ value	0.62314 (rank : 947)
Query Neighborhood Hits	1275	Target Neighborhood Hits	744	Shared Neighborhood Hits	154
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

FMN2_HUMAN
NC score	0.024305 (rank : 1085)	θ value	0.62314 (rank : 955)
Query Neighborhood Hits	1275	Target Neighborhood Hits	484	Shared Neighborhood Hits	133
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

PHLB2_MOUSE
NC score	0.024282 (rank : 1086)	θ value	8.99809 (rank : 1261)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1016	Shared Neighborhood Hits	126
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

BPTF_HUMAN
NC score	0.024209 (rank : 1087)	θ value	1.06291 (rank : 995)
Query Neighborhood Hits	1275	Target Neighborhood Hits	786	Shared Neighborhood Hits	178
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

FYB_HUMAN
NC score	0.023792 (rank : 1088)	θ value	1.38821 (rank : 1016)
Query Neighborhood Hits	1275	Target Neighborhood Hits	379	Shared Neighborhood Hits	92
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

MILK1_MOUSE
NC score	0.023775 (rank : 1089)	θ value	3.0926 (rank : 1098)
Query Neighborhood Hits	1275	Target Neighborhood Hits	788	Shared Neighborhood Hits	175
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

CO039_HUMAN
NC score	0.023723 (rank : 1090)	θ value	3.0926 (rank : 1092)
Query Neighborhood Hits	1275	Target Neighborhood Hits	264	Shared Neighborhood Hits	87
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

HIRP3_HUMAN
NC score	0.023687 (rank : 1091)	θ value	6.88961 (rank : 1204)
Query Neighborhood Hits	1275	Target Neighborhood Hits	323	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BW71, O75707, O75708	Gene names	HIRIP3
Domain Architecture	No domain graphic available
Description	HIRA-interacting protein 3.

K2027_HUMAN
NC score	0.023599 (rank : 1092)	θ value	0.163984 (rank : 890)
Query Neighborhood Hits	1275	Target Neighborhood Hits	194	Shared Neighborhood Hits	62
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

K0460_HUMAN
NC score	0.023451 (rank : 1093)	θ value	0.163984 (rank : 889)
Query Neighborhood Hits	1275	Target Neighborhood Hits	357	Shared Neighborhood Hits	89
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

MYO9B_MOUSE
NC score	0.023450 (rank : 1094)	θ value	5.27518 (rank : 1169)
Query Neighborhood Hits	1275	Target Neighborhood Hits	311	Shared Neighborhood Hits	72
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

FA47B_HUMAN
NC score	0.023294 (rank : 1095)	θ value	0.365318 (rank : 919)
Query Neighborhood Hits	1275	Target Neighborhood Hits	431	Shared Neighborhood Hits	102
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

CG1_HUMAN
NC score	0.023277 (rank : 1096)	θ value	2.36792 (rank : 1062)
Query Neighborhood Hits	1275	Target Neighborhood Hits	222	Shared Neighborhood Hits	70
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

MAGE1_HUMAN
NC score	0.023195 (rank : 1097)	θ value	6.88961 (rank : 1210)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1389	Shared Neighborhood Hits	238
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

CIR_MOUSE
NC score	0.022943 (rank : 1098)	θ value	0.62314 (rank : 949)
Query Neighborhood Hits	1275	Target Neighborhood Hits	255	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

SYMPK_HUMAN
NC score	0.022671 (rank : 1099)	θ value	0.0431538 (rank : 859)
Query Neighborhood Hits	1275	Target Neighborhood Hits	90	Shared Neighborhood Hits	32
SwissProt Accessions	Q92797, O00521, O00689, O00733, Q59GT5, Q8N2U5	Gene names	SYMPK, SPK
Domain Architecture	No domain graphic available
Description	Symplekin.

CO002_HUMAN
NC score	0.022625 (rank : 1100)	θ value	0.163984 (rank : 885)
Query Neighborhood Hits	1275	Target Neighborhood Hits	387	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

ARI4A_HUMAN
NC score	0.022619 (rank : 1101)	θ value	2.36792 (rank : 1058)
Query Neighborhood Hits	1275	Target Neighborhood Hits	434	Shared Neighborhood Hits	76
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

PHLB2_HUMAN
NC score	0.022578 (rank : 1102)	θ value	0.813845 (rank : 982)
Query Neighborhood Hits	1275	Target Neighborhood Hits	964	Shared Neighborhood Hits	114
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PRR8_HUMAN
NC score	0.022568 (rank : 1103)	θ value	6.88961 (rank : 1224)
Query Neighborhood Hits	1275	Target Neighborhood Hits	217	Shared Neighborhood Hits	72
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

CABIN_HUMAN
NC score	0.022559 (rank : 1104)	θ value	5.27518 (rank : 1145)
Query Neighborhood Hits	1275	Target Neighborhood Hits	490	Shared Neighborhood Hits	104
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

PHLB1_MOUSE
NC score	0.022497 (rank : 1105)	θ value	0.813845 (rank : 981)
Query Neighborhood Hits	1275	Target Neighborhood Hits	678	Shared Neighborhood Hits	114
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SETBP_MOUSE
NC score	0.022068 (rank : 1106)	θ value	0.279714 (rank : 912)
Query Neighborhood Hits	1275	Target Neighborhood Hits	352	Shared Neighborhood Hits	89
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

PHC3_MOUSE
NC score	0.021793 (rank : 1107)	θ value	1.06291 (rank : 1003)
Query Neighborhood Hits	1275	Target Neighborhood Hits	194	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CHP6, Q3TLV5	Gene names	Phc3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3.

MAML2_HUMAN
NC score	0.021453 (rank : 1108)	θ value	1.06291 (rank : 1000)
Query Neighborhood Hits	1275	Target Neighborhood Hits	360	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IZL2, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6	Gene names	MAML2, KIAA1819
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 2 (Mam-2).

BCL9_HUMAN
NC score	0.021443 (rank : 1109)	θ value	1.81305 (rank : 1030)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1008	Shared Neighborhood Hits	192
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

NEBU_HUMAN
NC score	0.021392 (rank : 1110)	θ value	4.03905 (rank : 1128)
Query Neighborhood Hits	1275	Target Neighborhood Hits	420	Shared Neighborhood Hits	70
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

SAPS1_HUMAN
NC score	0.021262 (rank : 1111)	θ value	0.47712 (rank : 938)
Query Neighborhood Hits	1275	Target Neighborhood Hits	704	Shared Neighborhood Hits	147
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

TXLNB_MOUSE
NC score	0.021152 (rank : 1112)	θ value	8.99809 (rank : 1272)
Query Neighborhood Hits	1275	Target Neighborhood Hits	640	Shared Neighborhood Hits	94
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

SMC1A_MOUSE
NC score	0.021012 (rank : 1113)	θ value	5.27518 (rank : 1180)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1384	Shared Neighborhood Hits	138
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

JPH2_HUMAN
NC score	0.020700 (rank : 1114)	θ value	2.36792 (rank : 1070)
Query Neighborhood Hits	1275	Target Neighborhood Hits	639	Shared Neighborhood Hits	127
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

CK5P2_HUMAN
NC score	0.020575 (rank : 1115)	θ value	0.279714 (rank : 901)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1433	Shared Neighborhood Hits	149
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

SYMPK_MOUSE
NC score	0.020547 (rank : 1116)	θ value	0.47712 (rank : 940)
Query Neighborhood Hits	1275	Target Neighborhood Hits	109	Shared Neighborhood Hits	33
SwissProt Accessions	Q80X82	Gene names	Sympk
Domain Architecture	No domain graphic available
Description	Symplekin.

RSF1_HUMAN
NC score	0.020514 (rank : 1117)	θ value	0.813845 (rank : 987)
Query Neighborhood Hits	1275	Target Neighborhood Hits	539	Shared Neighborhood Hits	100
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

AKAP5_HUMAN
NC score	0.020415 (rank : 1118)	θ value	0.0736092 (rank : 867)
Query Neighborhood Hits	1275	Target Neighborhood Hits	41	Shared Neighborhood Hits	10
SwissProt Accessions	P24588	Gene names	AKAP5, AKAP79
Domain Architecture
Description	A-kinase anchor protein 5 (A-kinase anchor protein 79 kDa) (AKAP 79) (cAMP-dependent protein kinase regulatory subunit II high affinity- binding protein) (H21).

GON4L_HUMAN
NC score	0.020187 (rank : 1119)	θ value	0.813845 (rank : 970)
Query Neighborhood Hits	1275	Target Neighborhood Hits	555	Shared Neighborhood Hits	115
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

MKL1_MOUSE
NC score	0.020144 (rank : 1120)	θ value	1.81305 (rank : 1045)
Query Neighborhood Hits	1275	Target Neighborhood Hits	667	Shared Neighborhood Hits	131
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

HCFC1_HUMAN
NC score	0.019995 (rank : 1121)	θ value	0.0563607 (rank : 862)
Query Neighborhood Hits	1275	Target Neighborhood Hits	331	Shared Neighborhood Hits	79
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

RIMS1_HUMAN
NC score	0.019834 (rank : 1122)	θ value	0.813845 (rank : 986)
Query Neighborhood Hits	1275	Target Neighborhood Hits	437	Shared Neighborhood Hits	82
SwissProt Accessions	Q86UR5, O15048, Q8TDY9, Q8TDZ5, Q9HBA1, Q9HBA2, Q9HBA3, Q9HBA4, Q9HBA5, Q9HBA6	Gene names	RIMS1, KIAA0340, RIM1
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 1 (Rab3-interacting molecule 1) (RIM 1).

GOGB1_HUMAN
NC score	0.019746 (rank : 1123)	θ value	1.38821 (rank : 1018)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2297	Shared Neighborhood Hits	213
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

BAG3_MOUSE
NC score	0.019631 (rank : 1124)	θ value	4.03905 (rank : 1111)
Query Neighborhood Hits	1275	Target Neighborhood Hits	513	Shared Neighborhood Hits	137
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

MYCB2_HUMAN
NC score	0.019336 (rank : 1125)	θ value	4.03905 (rank : 1126)
Query Neighborhood Hits	1275	Target Neighborhood Hits	390	Shared Neighborhood Hits	79
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

BAZ2A_HUMAN
NC score	0.019167 (rank : 1126)	θ value	1.38821 (rank : 1012)
Query Neighborhood Hits	1275	Target Neighborhood Hits	780	Shared Neighborhood Hits	153
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

MUC5B_HUMAN
NC score	0.019119 (rank : 1127)	θ value	4.03905 (rank : 1125)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1020	Shared Neighborhood Hits	164
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

CD2_HUMAN
NC score	0.019074 (rank : 1128)	θ value	1.81305 (rank : 1031)
Query Neighborhood Hits	1275	Target Neighborhood Hits	504	Shared Neighborhood Hits	114
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

SMC1A_HUMAN
NC score	0.019031 (rank : 1129)	θ value	5.27518 (rank : 1179)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1346	Shared Neighborhood Hits	134
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

CK5P2_MOUSE
NC score	0.018808 (rank : 1130)	θ value	5.27518 (rank : 1152)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1151	Shared Neighborhood Hits	126
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

PHC3_HUMAN
NC score	0.018645 (rank : 1131)	θ value	0.365318 (rank : 923)
Query Neighborhood Hits	1275	Target Neighborhood Hits	218	Shared Neighborhood Hits	69
SwissProt Accessions	Q8NDX5, Q5HYF0, Q6NSG2, Q8NFT7, Q8NFZ1, Q8TBM2, Q9H971, Q9H9I4	Gene names	PHC3, EDR3, PH3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3 (hPH3) (Homolog of polyhomeotic 3) (Early development regulatory protein 3).

3BP2_HUMAN
NC score	0.018560 (rank : 1132)	θ value	3.0926 (rank : 1086)
Query Neighborhood Hits	1275	Target Neighborhood Hits	296	Shared Neighborhood Hits	65
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CUTL1_MOUSE
NC score	0.018538 (rank : 1133)	θ value	4.03905 (rank : 1114)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1620	Shared Neighborhood Hits	198
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CJ118_MOUSE
NC score	0.018411 (rank : 1134)	θ value	1.81305 (rank : 1033)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1132	Shared Neighborhood Hits	108
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

EPS8_MOUSE
NC score	0.018317 (rank : 1135)	θ value	8.99809 (rank : 1249)
Query Neighborhood Hits	1275	Target Neighborhood Hits	157	Shared Neighborhood Hits	37
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

HCFC1_MOUSE
NC score	0.018313 (rank : 1136)	θ value	3.0926 (rank : 1096)
Query Neighborhood Hits	1275	Target Neighborhood Hits	348	Shared Neighborhood Hits	79
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

IL3B2_MOUSE
NC score	0.018290 (rank : 1137)	θ value	0.279714 (rank : 906)
Query Neighborhood Hits	1275	Target Neighborhood Hits	372	Shared Neighborhood Hits	69
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

MPP8_HUMAN
NC score	0.018276 (rank : 1138)	θ value	2.36792 (rank : 1072)
Query Neighborhood Hits	1275	Target Neighborhood Hits	948	Shared Neighborhood Hits	124
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

CJ047_MOUSE
NC score	0.018252 (rank : 1139)	θ value	0.365318 (rank : 918)
Query Neighborhood Hits	1275	Target Neighborhood Hits	76	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C5R2, Q8R017, Q8R2Z9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf47 homolog.

ENAM_HUMAN
NC score	0.018184 (rank : 1140)	θ value	0.163984 (rank : 886)
Query Neighborhood Hits	1275	Target Neighborhood Hits	227	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

CUTL1_HUMAN
NC score	0.018020 (rank : 1141)	θ value	0.0961366 (rank : 871)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1574	Shared Neighborhood Hits	186
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

ALMS1_HUMAN
NC score	0.017989 (rank : 1142)	θ value	1.38821 (rank : 1009)
Query Neighborhood Hits	1275	Target Neighborhood Hits	356	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

SGIP1_HUMAN
NC score	0.017867 (rank : 1143)	θ value	8.99809 (rank : 1265)
Query Neighborhood Hits	1275	Target Neighborhood Hits	198	Shared Neighborhood Hits	75
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

ZN645_HUMAN
NC score	0.017701 (rank : 1144)	θ value	0.62314 (rank : 964)
Query Neighborhood Hits	1275	Target Neighborhood Hits	265	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

APC_HUMAN
NC score	0.017690 (rank : 1145)	θ value	8.99809 (rank : 1241)
Query Neighborhood Hits	1275	Target Neighborhood Hits	603	Shared Neighborhood Hits	133
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

SVIL_HUMAN
NC score	0.017661 (rank : 1146)	θ value	0.125558 (rank : 882)
Query Neighborhood Hits	1275	Target Neighborhood Hits	232	Shared Neighborhood Hits	56
SwissProt Accessions	O95425, O60611, O60612, Q5VZK5, Q5VZK6, Q9H1R7	Gene names	SVIL
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

NTBP1_MOUSE
NC score	0.017389 (rank : 1147)	θ value	1.38821 (rank : 1022)
Query Neighborhood Hits	1275	Target Neighborhood Hits	528	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

CI079_HUMAN
NC score	0.017247 (rank : 1148)	θ value	1.81305 (rank : 1032)
Query Neighborhood Hits	1275	Target Neighborhood Hits	288	Shared Neighborhood Hits	74
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

ARI5B_HUMAN
NC score	0.017235 (rank : 1149)	θ value	3.0926 (rank : 1090)
Query Neighborhood Hits	1275	Target Neighborhood Hits	328	Shared Neighborhood Hits	65
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

DCP1A_HUMAN
NC score	0.017120 (rank : 1150)	θ value	5.27518 (rank : 1156)
Query Neighborhood Hits	1275	Target Neighborhood Hits	228	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

NPAS4_MOUSE
NC score	0.017104 (rank : 1151)	θ value	0.0961366 (rank : 873)
Query Neighborhood Hits	1275	Target Neighborhood Hits	245	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

F8I2_MOUSE
NC score	0.017058 (rank : 1152)	θ value	0.0431538 (rank : 857)
Query Neighborhood Hits	1275	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q00558	Gene names	F8a1, F8a
Domain Architecture	No domain graphic available
Description	Factor VIII intron 22 protein (CpG island protein).

BPAEA_MOUSE
NC score	0.016799 (rank : 1153)	θ value	5.27518 (rank : 1144)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1480	Shared Neighborhood Hits	148
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

GA2L2_MOUSE
NC score	0.016760 (rank : 1154)	θ value	1.38821 (rank : 1017)
Query Neighborhood Hits	1275	Target Neighborhood Hits	395	Shared Neighborhood Hits	97
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

SMRC1_HUMAN
NC score	0.016627 (rank : 1155)	θ value	1.38821 (rank : 1026)
Query Neighborhood Hits	1275	Target Neighborhood Hits	375	Shared Neighborhood Hits	92
SwissProt Accessions	Q92922, Q6P172, Q8IWH2	Gene names	SMARCC1, BAF155
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 (SWI/SNF complex 155 kDa subunit) (BRG1-associated factor 155).

PSL1_HUMAN
NC score	0.016435 (rank : 1156)	θ value	1.81305 (rank : 1050)
Query Neighborhood Hits	1275	Target Neighborhood Hits	650	Shared Neighborhood Hits	115
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RAD50_HUMAN
NC score	0.016343 (rank : 1157)	θ value	4.03905 (rank : 1134)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1317	Shared Neighborhood Hits	133
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

BAT3_MOUSE
NC score	0.016170 (rank : 1158)	θ value	2.36792 (rank : 1060)
Query Neighborhood Hits	1275	Target Neighborhood Hits	518	Shared Neighborhood Hits	114
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

CEL_HUMAN
NC score	0.016111 (rank : 1159)	θ value	0.00665767 (rank : 832)
Query Neighborhood Hits	1275	Target Neighborhood Hits	896	Shared Neighborhood Hits	166
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

TNC6B_HUMAN
NC score	0.016050 (rank : 1160)	θ value	0.21417 (rank : 897)
Query Neighborhood Hits	1275	Target Neighborhood Hits	256	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPQ9, Q5TH52, Q8TBX2	Gene names	TNRC6B, KIAA1093
Domain Architecture
Description	Trinucleotide repeat-containing 6B protein.

GCC2_MOUSE
NC score	0.016043 (rank : 1161)	θ value	0.62314 (rank : 956)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1619	Shared Neighborhood Hits	153
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

SPR1B_MOUSE
NC score	0.016025 (rank : 1162)	θ value	1.06291 (rank : 1005)
Query Neighborhood Hits	1275	Target Neighborhood Hits	395	Shared Neighborhood Hits	85
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

BAT3_HUMAN
NC score	0.015984 (rank : 1163)	θ value	1.81305 (rank : 1029)
Query Neighborhood Hits	1275	Target Neighborhood Hits	490	Shared Neighborhood Hits	97
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

ADRM1_MOUSE
NC score	0.015962 (rank : 1164)	θ value	0.47712 (rank : 929)
Query Neighborhood Hits	1275	Target Neighborhood Hits	84	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JKV1	Gene names	Adrm1, Gp110
Domain Architecture
Description	Adhesion-regulating molecule 1 precursor (110 kDa cell membrane glycoprotein) (Gp110) (ARM-1).

SNPC4_MOUSE
NC score	0.015881 (rank : 1165)	θ value	2.36792 (rank : 1082)
Query Neighborhood Hits	1275	Target Neighborhood Hits	237	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

ANR26_HUMAN
NC score	0.015810 (rank : 1166)	θ value	8.99809 (rank : 1240)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1614	Shared Neighborhood Hits	151
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

SEPT9_HUMAN
NC score	0.015791 (rank : 1167)	θ value	0.125558 (rank : 880)
Query Neighborhood Hits	1275	Target Neighborhood Hits	706	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

KMHN1_HUMAN
NC score	0.015738 (rank : 1168)	θ value	6.88961 (rank : 1207)
Query Neighborhood Hits	1275	Target Neighborhood Hits	950	Shared Neighborhood Hits	100
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

KTN1_MOUSE
NC score	0.015623 (rank : 1169)	θ value	6.88961 (rank : 1208)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1324	Shared Neighborhood Hits	140
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

UACA_MOUSE
NC score	0.015468 (rank : 1170)	θ value	8.99809 (rank : 1273)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1620	Shared Neighborhood Hits	145
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

IL3RB_MOUSE
NC score	0.015464 (rank : 1171)	θ value	2.36792 (rank : 1068)
Query Neighborhood Hits	1275	Target Neighborhood Hits	355	Shared Neighborhood Hits	66
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

MYO15_HUMAN
NC score	0.015253 (rank : 1172)	θ value	4.03905 (rank : 1127)
Query Neighborhood Hits	1275	Target Neighborhood Hits	671	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

GAK6_HUMAN
NC score	0.015107 (rank : 1173)	θ value	0.125558 (rank : 878)
Query Neighborhood Hits	1275	Target Neighborhood Hits	392	Shared Neighborhood Hits	87
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

REPS2_MOUSE
NC score	0.015085 (rank : 1174)	θ value	0.62314 (rank : 962)
Query Neighborhood Hits	1275	Target Neighborhood Hits	102	Shared Neighborhood Hits	33
SwissProt Accessions	Q80XA6	Gene names	Reps2, Pob1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

TMC2_MOUSE
NC score	0.015077 (rank : 1175)	θ value	1.81305 (rank : 1055)
Query Neighborhood Hits	1275	Target Neighborhood Hits	249	Shared Neighborhood Hits	56
SwissProt Accessions	Q8R4P4	Gene names	Tmc2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

SC24A_MOUSE
NC score	0.015049 (rank : 1176)	θ value	0.279714 (rank : 910)
Query Neighborhood Hits	1275	Target Neighborhood Hits	394	Shared Neighborhood Hits	94
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

PHC1_MOUSE
NC score	0.014966 (rank : 1177)	θ value	6.88961 (rank : 1220)
Query Neighborhood Hits	1275	Target Neighborhood Hits	205	Shared Neighborhood Hits	66
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

LR37A_HUMAN
NC score	0.014938 (rank : 1178)	θ value	5.27518 (rank : 1166)
Query Neighborhood Hits	1275	Target Neighborhood Hits	720	Shared Neighborhood Hits	154
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

NPAS4_HUMAN
NC score	0.014914 (rank : 1179)	θ value	0.365318 (rank : 922)
Query Neighborhood Hits	1275	Target Neighborhood Hits	214	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

K1210_HUMAN
NC score	0.014887 (rank : 1180)	θ value	1.81305 (rank : 1042)
Query Neighborhood Hits	1275	Target Neighborhood Hits	219	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

ZC11A_HUMAN
NC score	0.014878 (rank : 1181)	θ value	6.88961 (rank : 1237)
Query Neighborhood Hits	1275	Target Neighborhood Hits	170	Shared Neighborhood Hits	36
SwissProt Accessions	O75152, Q6AHY4, Q6AHY9, Q6AW79, Q6AWA1, Q6PJK4, Q86XZ7	Gene names	ZC3H11A, KIAA0663
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 11A.

CENPE_HUMAN
NC score	0.014789 (rank : 1182)	θ value	0.47712 (rank : 931)
Query Neighborhood Hits	1275	Target Neighborhood Hits	2060	Shared Neighborhood Hits	188
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

MEGF9_MOUSE
NC score	0.014765 (rank : 1183)	θ value	0.813845 (rank : 975)
Query Neighborhood Hits	1275	Target Neighborhood Hits	896	Shared Neighborhood Hits	151
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

K1802_MOUSE
NC score	0.014763 (rank : 1184)	θ value	1.38821 (rank : 1021)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1596	Shared Neighborhood Hits	233
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

ELOA1_MOUSE
NC score	0.014576 (rank : 1185)	θ value	0.62314 (rank : 951)
Query Neighborhood Hits	1275	Target Neighborhood Hits	152	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CB77, Q80VB2, Q9R0Q5	Gene names	Tceb3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

K0831_MOUSE
NC score	0.014537 (rank : 1186)	θ value	5.27518 (rank : 1162)
Query Neighborhood Hits	1275	Target Neighborhood Hits	277	Shared Neighborhood Hits	42
SwissProt Accessions	Q8CDJ3, Q69ZY1, Q6PFY6, Q8C6N0, Q8R3M3	Gene names	Kiaa0831, D14Ertd436e
Domain Architecture	No domain graphic available
Description	Protein KIAA0831.

TCF20_HUMAN
NC score	0.014496 (rank : 1187)	θ value	1.06291 (rank : 1007)
Query Neighborhood Hits	1275	Target Neighborhood Hits	323	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

ATX7_HUMAN
NC score	0.014399 (rank : 1188)	θ value	1.38821 (rank : 1010)
Query Neighborhood Hits	1275	Target Neighborhood Hits	351	Shared Neighborhood Hits	80
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

CN145_MOUSE
NC score	0.014374 (rank : 1189)	θ value	8.99809 (rank : 1244)
Query Neighborhood Hits	1275	Target Neighborhood Hits	916	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

ANLN_MOUSE
NC score	0.014342 (rank : 1190)	θ value	8.99809 (rank : 1238)
Query Neighborhood Hits	1275	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	Q8K298, Q8BL79, Q8BLB3, Q8K2N0, Q9CUY0	Gene names	Anln
Domain Architecture	No domain graphic available
Description	Actin-binding protein anillin.

IF4G1_MOUSE
NC score	0.014268 (rank : 1191)	θ value	0.813845 (rank : 973)
Query Neighborhood Hits	1275	Target Neighborhood Hits	534	Shared Neighborhood Hits	109
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

GAK5_HUMAN
NC score	0.014198 (rank : 1192)	θ value	0.813845 (rank : 969)
Query Neighborhood Hits	1275	Target Neighborhood Hits	429	Shared Neighborhood Hits	91
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.014194 (rank : 1193)	θ value	0.279714 (rank : 903)
Query Neighborhood Hits	1275	Target Neighborhood Hits	409	Shared Neighborhood Hits	86
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

SETX_HUMAN
NC score	0.014059 (rank : 1194)	θ value	0.813845 (rank : 988)
Query Neighborhood Hits	1275	Target Neighborhood Hits	368	Shared Neighborhood Hits	67
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

GAK4_HUMAN
NC score	0.013831 (rank : 1195)	θ value	0.279714 (rank : 904)
Query Neighborhood Hits	1275	Target Neighborhood Hits	415	Shared Neighborhood Hits	89
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

DOK2_MOUSE
NC score	0.013784 (rank : 1196)	θ value	0.62314 (rank : 950)
Query Neighborhood Hits	1275	Target Neighborhood Hits	244	Shared Neighborhood Hits	53
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

GAK2_HUMAN
NC score	0.013647 (rank : 1197)	θ value	0.47712 (rank : 933)
Query Neighborhood Hits	1275	Target Neighborhood Hits	406	Shared Neighborhood Hits	84
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GON4L_MOUSE
NC score	0.013430 (rank : 1198)	θ value	1.81305 (rank : 1038)
Query Neighborhood Hits	1275	Target Neighborhood Hits	455	Shared Neighborhood Hits	93
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

PLEC1_HUMAN
NC score	0.013101 (rank : 1199)	θ value	0.813845 (rank : 984)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1326	Shared Neighborhood Hits	134
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

SF3B1_MOUSE
NC score	0.013034 (rank : 1200)	θ value	1.81305 (rank : 1052)
Query Neighborhood Hits	1275	Target Neighborhood Hits	352	Shared Neighborhood Hits	67
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SETD2_HUMAN
NC score	0.012965 (rank : 1201)	θ value	1.38821 (rank : 1024)
Query Neighborhood Hits	1275	Target Neighborhood Hits	412	Shared Neighborhood Hits	95
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

U689_HUMAN
NC score	0.012882 (rank : 1202)	θ value	0.813845 (rank : 992)
Query Neighborhood Hits	1275	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q6UX39	Gene names	ames=UNQ689/PRO1329
Domain Architecture	No domain graphic available
Description	Protein UNQ689/PRO1329 precursor.

CD248_HUMAN
NC score	0.012881 (rank : 1203)	θ value	0.125558 (rank : 876)
Query Neighborhood Hits	1275	Target Neighborhood Hits	679	Shared Neighborhood Hits	127
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

COHA1_HUMAN
NC score	0.012836 (rank : 1204)	θ value	0.0961366 (rank : 870)
Query Neighborhood Hits	1275	Target Neighborhood Hits	400	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

GAK12_HUMAN
NC score	0.012717 (rank : 1205)	θ value	0.813845 (rank : 968)
Query Neighborhood Hits	1275	Target Neighborhood Hits	374	Shared Neighborhood Hits	82
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

AL2S4_MOUSE
NC score	0.012686 (rank : 1206)	θ value	6.88961 (rank : 1189)
Query Neighborhood Hits	1275	Target Neighborhood Hits	193	Shared Neighborhood Hits	49
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

ANK3_HUMAN
NC score	0.012647 (rank : 1207)	θ value	1.06291 (rank : 993)
Query Neighborhood Hits	1275	Target Neighborhood Hits	853	Shared Neighborhood Hits	144
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

SRBP1_MOUSE
NC score	0.012518 (rank : 1208)	θ value	0.279714 (rank : 913)
Query Neighborhood Hits	1275	Target Neighborhood Hits	384	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MBB1A_MOUSE
NC score	0.012512 (rank : 1209)	θ value	8.99809 (rank : 1254)
Query Neighborhood Hits	1275	Target Neighborhood Hits	233	Shared Neighborhood Hits	56
SwissProt Accessions	Q7TPV4, O35851, Q80Y66, Q8R4X2, Q99KP0	Gene names	Mybbp1a, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A (Myb-binding protein of 160 kDa).

EP15R_MOUSE
NC score	0.012502 (rank : 1210)	θ value	6.88961 (rank : 1197)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1135	Shared Neighborhood Hits	129
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

LEO1_MOUSE
NC score	0.012451 (rank : 1211)	θ value	2.36792 (rank : 1071)
Query Neighborhood Hits	1275	Target Neighborhood Hits	946	Shared Neighborhood Hits	99
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

HEMGN_MOUSE
NC score	0.012426 (rank : 1212)	θ value	0.813845 (rank : 971)
Query Neighborhood Hits	1275	Target Neighborhood Hits	81	Shared Neighborhood Hits	27
SwissProt Accessions	Q9ERZ0, Q3TAE6, Q80YT2, Q8CF29	Gene names	Hemgn, Ndr
Domain Architecture	No domain graphic available
Description	Hemogen (Hemopoietic gene protein) (Negative differentiation regulator protein) (mNDR).

PDZD2_HUMAN
NC score	0.012295 (rank : 1213)	θ value	2.36792 (rank : 1076)
Query Neighborhood Hits	1275	Target Neighborhood Hits	772	Shared Neighborhood Hits	126
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

GAK10_HUMAN
NC score	0.012237 (rank : 1214)	θ value	6.88961 (rank : 1202)
Query Neighborhood Hits	1275	Target Neighborhood Hits	289	Shared Neighborhood Hits	68
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HRX_HUMAN
NC score	0.012181 (rank : 1215)	θ value	6.88961 (rank : 1205)
Query Neighborhood Hits	1275	Target Neighborhood Hits	825	Shared Neighborhood Hits	167
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

TAF6_MOUSE
NC score	0.012112 (rank : 1216)	θ value	8.99809 (rank : 1268)
Query Neighborhood Hits	1275	Target Neighborhood Hits	110	Shared Neighborhood Hits	49
SwissProt Accessions	Q62311	Gene names	Taf6, Taf2e
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80) (p80).

NFM_HUMAN
NC score	0.012096 (rank : 1217)	θ value	3.0926 (rank : 1102)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1328	Shared Neighborhood Hits	198
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

PP1RA_HUMAN
NC score	0.011644 (rank : 1218)	θ value	1.81305 (rank : 1049)
Query Neighborhood Hits	1275	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q96QC0, O00405	Gene names	PPP1R10, CAT53, FB19, PNUTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 1 regulatory subunit 10 (Phosphatase 1 nuclear targeting subunit) (MHC class I region proline- rich protein CAT53) (FB19 protein) (PP1-binding protein of 114 kDa) (p99).

FADD_MOUSE
NC score	0.011546 (rank : 1219)	θ value	6.88961 (rank : 1199)
Query Neighborhood Hits	1275	Target Neighborhood Hits	23	Shared Neighborhood Hits	6
SwissProt Accessions	Q61160, Q3TC37, Q61082	Gene names	Fadd, Mort1
Domain Architecture
Description	FADD protein (FAS-associating death domain-containing protein) (Mediator of receptor induced toxicity).

GAB2_MOUSE
NC score	0.011540 (rank : 1220)	θ value	5.27518 (rank : 1158)
Query Neighborhood Hits	1275	Target Neighborhood Hits	220	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

ABLM3_MOUSE
NC score	0.011429 (rank : 1221)	θ value	0.00298849 (rank : 825)
Query Neighborhood Hits	1275	Target Neighborhood Hits	294	Shared Neighborhood Hits	25
SwissProt Accessions	Q69ZX8, Q52KR1, Q6PAI7	Gene names	Ablim3, Kiaa0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

LIPA3_HUMAN
NC score	0.011307 (rank : 1222)	θ value	4.03905 (rank : 1122)
Query Neighborhood Hits	1275	Target Neighborhood Hits	828	Shared Neighborhood Hits	96
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

PER2_MOUSE
NC score	0.011261 (rank : 1223)	θ value	1.38821 (rank : 1023)
Query Neighborhood Hits	1275	Target Neighborhood Hits	325	Shared Neighborhood Hits	51
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

REPS2_HUMAN
NC score	0.011215 (rank : 1224)	θ value	8.99809 (rank : 1262)
Query Neighborhood Hits	1275	Target Neighborhood Hits	131	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NFH8, O43428, Q8NFI5	Gene names	REPS2, POB1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 2 (RalBP1-interacting protein 2) (Partner of RalBP1).

IPR1_MOUSE
NC score	0.011196 (rank : 1225)	θ value	0.279714 (rank : 907)
Query Neighborhood Hits	1275	Target Neighborhood Hits	65	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BVK9, Q3UCV7, Q80V00	Gene names	Ipr1, Ifi75
Domain Architecture	No domain graphic available
Description	Intracellular pathogen resistance protein 1.

RTKN_HUMAN
NC score	0.011128 (rank : 1226)	θ value	0.365318 (rank : 926)
Query Neighborhood Hits	1275	Target Neighborhood Hits	97	Shared Neighborhood Hits	24
SwissProt Accessions	Q9BST9, Q8WVN1, Q96PT6, Q9HB05	Gene names	RTKN
Domain Architecture	No domain graphic available
Description	Rhotekin.

CBL_MOUSE
NC score	0.011072 (rank : 1227)	θ value	0.0148317 (rank : 838)
Query Neighborhood Hits	1275	Target Neighborhood Hits	426	Shared Neighborhood Hits	65
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

EVI2B_HUMAN
NC score	0.011024 (rank : 1228)	θ value	1.81305 (rank : 1034)
Query Neighborhood Hits	1275	Target Neighborhood Hits	135	Shared Neighborhood Hits	37
SwissProt Accessions	P34910	Gene names	EVI2B, EVDB
Domain Architecture	No domain graphic available
Description	EVI2B protein precursor (Ecotropic viral integration site 2B protein).

DDEF1_MOUSE
NC score	0.010864 (rank : 1229)	θ value	0.279714 (rank : 902)
Query Neighborhood Hits	1275	Target Neighborhood Hits	592	Shared Neighborhood Hits	104
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CB017_MOUSE
NC score	0.010591 (rank : 1230)	θ value	5.27518 (rank : 1148)
Query Neighborhood Hits	1275	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	Q6NS82, Q3TA48, Q8BSD3, Q8CHY1, Q8R0Q3	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf17 homolog.

AHTF1_HUMAN
NC score	0.010579 (rank : 1231)	θ value	3.0926 (rank : 1088)
Query Neighborhood Hits	1275	Target Neighborhood Hits	286	Shared Neighborhood Hits	62
SwissProt Accessions	Q8WYP5, Q7Z4E3, Q8IZA4, Q96EH9, Q9Y4Q6	Gene names	AHCTF1, ELYS, TMBS62
Domain Architecture	No domain graphic available
Description	AT-hook-containing transcription factor 1 (Embryonic large molecule derived from yolk sac).

BCOR_HUMAN
NC score	0.010454 (rank : 1232)	θ value	2.36792 (rank : 1061)
Query Neighborhood Hits	1275	Target Neighborhood Hits	609	Shared Neighborhood Hits	93
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

FA5_HUMAN
NC score	0.010427 (rank : 1233)	θ value	0.365318 (rank : 920)
Query Neighborhood Hits	1275	Target Neighborhood Hits	172	Shared Neighborhood Hits	38
SwissProt Accessions	P12259, Q14285, Q6UPU6	Gene names	F5
Domain Architecture
Description	Coagulation factor V precursor (Activated protein C cofactor) [Contains: Coagulation factor V heavy chain; Coagulation factor V light chain].

RUFY1_MOUSE
NC score	0.010369 (rank : 1234)	θ value	5.27518 (rank : 1176)
Query Neighborhood Hits	1275	Target Neighborhood Hits	765	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

CGRE1_MOUSE
NC score	0.010292 (rank : 1235)	θ value	6.88961 (rank : 1195)
Query Neighborhood Hits	1275	Target Neighborhood Hits	173	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R1U2, Q9D1K1	Gene names	Cgref1, Cgr11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

HSF1_MOUSE
NC score	0.010192 (rank : 1236)	θ value	1.38821 (rank : 1019)
Query Neighborhood Hits	1275	Target Neighborhood Hits	267	Shared Neighborhood Hits	55
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

IF4G3_MOUSE
NC score	0.010185 (rank : 1237)	θ value	4.03905 (rank : 1118)
Query Neighborhood Hits	1275	Target Neighborhood Hits	279	Shared Neighborhood Hits	74
SwissProt Accessions	Q80XI3, Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0	Gene names	Eif4g3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

UBQL1_MOUSE
NC score	0.010099 (rank : 1238)	θ value	0.0113563 (rank : 837)
Query Neighborhood Hits	1275	Target Neighborhood Hits	86	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R317, Q80V10, Q8C7T4, Q8C835, Q8K141, Q91VI8, Q9D0Z0, Q9QZM1	Gene names	Ubqln1, Plic1
Domain Architecture
Description	Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1).

GAK1_HUMAN
NC score	0.009511 (rank : 1239)	θ value	3.0926 (rank : 1095)
Query Neighborhood Hits	1275	Target Neighborhood Hits	268	Shared Neighborhood Hits	60
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MACF4_HUMAN
NC score	0.009406 (rank : 1240)	θ value	6.88961 (rank : 1209)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1321	Shared Neighborhood Hits	133
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

UBQL2_MOUSE
NC score	0.009273 (rank : 1241)	θ value	0.279714 (rank : 914)
Query Neighborhood Hits	1275	Target Neighborhood Hits	114	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZM0, Q7TSJ8, Q8VDH9	Gene names	Ubqln2, Plic2
Domain Architecture
Description	Ubiquilin-2 (Protein linking IAP with cytoskeleton 2) (PLIC-2) (Ubiquitin-like product Chap1/Dsk2) (DSK2 homolog) (Chap1).

SPR1A_MOUSE
NC score	0.009263 (rank : 1242)	θ value	6.88961 (rank : 1230)
Query Neighborhood Hits	1275	Target Neighborhood Hits	343	Shared Neighborhood Hits	65
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SCG3_HUMAN
NC score	0.009021 (rank : 1243)	θ value	8.99809 (rank : 1263)
Query Neighborhood Hits	1275	Target Neighborhood Hits	125	Shared Neighborhood Hits	28
SwissProt Accessions	Q8WXD2, Q96C83, Q96GE8, Q9Y6G7	Gene names	SCG3
Domain Architecture	No domain graphic available
Description	Secretogranin-3 precursor (Secretogranin III) (SgIII).

JIP1_MOUSE
NC score	0.008899 (rank : 1244)	θ value	2.36792 (rank : 1069)
Query Neighborhood Hits	1275	Target Neighborhood Hits	259	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

OBF1_MOUSE
NC score	0.008848 (rank : 1245)	θ value	1.81305 (rank : 1046)
Query Neighborhood Hits	1275	Target Neighborhood Hits	73	Shared Neighborhood Hits	17
SwissProt Accessions	Q64693	Gene names	Pou2af1, Obf-1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (BOB1) (OCA-B).

TRI66_HUMAN
NC score	0.008656 (rank : 1246)	θ value	0.21417 (rank : 898)
Query Neighborhood Hits	1275	Target Neighborhood Hits	479	Shared Neighborhood Hits	108
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ST5_MOUSE
NC score	0.008512 (rank : 1247)	θ value	0.813845 (rank : 989)
Query Neighborhood Hits	1275	Target Neighborhood Hits	126	Shared Neighborhood Hits	41
SwissProt Accessions	Q924W7, Q78H54, Q8K2P3, Q924W8	Gene names	St5, Dennd2b
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (DENN domain-containing protein 2B).

YETS2_HUMAN
NC score	0.008464 (rank : 1248)	θ value	6.88961 (rank : 1236)
Query Neighborhood Hits	1275	Target Neighborhood Hits	212	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ULM3, Q641P6, Q9NW96	Gene names	YEATS2, KIAA1197
Domain Architecture	No domain graphic available
Description	YEATS domain-containing protein 2.

ABLM3_HUMAN
NC score	0.008413 (rank : 1249)	θ value	0.813845 (rank : 965)
Query Neighborhood Hits	1275	Target Neighborhood Hits	293	Shared Neighborhood Hits	27
SwissProt Accessions	O94929, Q658S1, Q68CI5, Q9BV32	Gene names	ABLIM3, KIAA0843
Domain Architecture	No domain graphic available
Description	Actin-binding LIM protein 3 (Actin-binding LIM protein family member 3) (abLIM-3).

TULP4_HUMAN
NC score	0.008386 (rank : 1250)	θ value	6.88961 (rank : 1233)
Query Neighborhood Hits	1275	Target Neighborhood Hits	426	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

NFM_MOUSE
NC score	0.008374 (rank : 1251)	θ value	2.36792 (rank : 1074)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1159	Shared Neighborhood Hits	141
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

UBP53_MOUSE
NC score	0.008117 (rank : 1252)	θ value	0.47712 (rank : 942)
Query Neighborhood Hits	1275	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

YAP1_HUMAN
NC score	0.008013 (rank : 1253)	θ value	4.03905 (rank : 1139)
Query Neighborhood Hits	1275	Target Neighborhood Hits	173	Shared Neighborhood Hits	51
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ST5_HUMAN
NC score	0.008009 (rank : 1254)	θ value	0.21417 (rank : 896)
Query Neighborhood Hits	1275	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	P78524, P78523, Q16492, Q7KYY2, Q7KZ12, Q8NE12, Q9BQQ6	Gene names	ST5, DENND2B, HTS1
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity 5 (HeLa tumor suppression 1) (DENN domain-containing protein 2B).

TPO_MOUSE
NC score	0.007975 (rank : 1255)	θ value	4.03905 (rank : 1136)
Query Neighborhood Hits	1275	Target Neighborhood Hits	258	Shared Neighborhood Hits	45
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

DAB1_HUMAN
NC score	0.007795 (rank : 1256)	θ value	2.36792 (rank : 1064)
Query Neighborhood Hits	1275	Target Neighborhood Hits	219	Shared Neighborhood Hits	52
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

COHA1_MOUSE
NC score	0.007745 (rank : 1257)	θ value	4.03905 (rank : 1112)
Query Neighborhood Hits	1275	Target Neighborhood Hits	414	Shared Neighborhood Hits	79
SwissProt Accessions	Q07563, Q99LK8	Gene names	Col17a1, Bp180, Bpag2
Domain Architecture
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

GCM2_HUMAN
NC score	0.007602 (rank : 1258)	θ value	0.279714 (rank : 905)
Query Neighborhood Hits	1275	Target Neighborhood Hits	53	Shared Neighborhood Hits	13
SwissProt Accessions	O75603	Gene names	GCM2, GCMB
Domain Architecture
Description	Chorion-specific transcription factor GCMb (Glial cells missing homolog 2) (GCM motif protein 2) (hGCMb).

CBL_HUMAN
NC score	0.007321 (rank : 1259)	θ value	0.813845 (rank : 967)
Query Neighborhood Hits	1275	Target Neighborhood Hits	353	Shared Neighborhood Hits	50
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

GAB1_MOUSE
NC score	0.007187 (rank : 1260)	θ value	6.88961 (rank : 1201)
Query Neighborhood Hits	1275	Target Neighborhood Hits	233	Shared Neighborhood Hits	52
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GNAS1_MOUSE
NC score	0.007142 (rank : 1261)	θ value	1.06291 (rank : 999)
Query Neighborhood Hits	1275	Target Neighborhood Hits	651	Shared Neighborhood Hits	120
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

SOX13_MOUSE
NC score	0.007137 (rank : 1262)	θ value	1.81305 (rank : 1053)
Query Neighborhood Hits	1275	Target Neighborhood Hits	495	Shared Neighborhood Hits	100
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

ICB1_MOUSE
NC score	0.007102 (rank : 1263)	θ value	0.813845 (rank : 972)
Query Neighborhood Hits	1275	Target Neighborhood Hits	69	Shared Neighborhood Hits	20
SwissProt Accessions	Q91YX0	Gene names	Icb1
Domain Architecture	No domain graphic available
Description	Induced by contact to basement membrane 1 protein homolog (ICB-1 protein).

CD248_MOUSE
NC score	0.007085 (rank : 1264)	θ value	0.365318 (rank : 916)
Query Neighborhood Hits	1275	Target Neighborhood Hits	578	Shared Neighborhood Hits	96
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

MAGI2_MOUSE
NC score	0.007019 (rank : 1265)	θ value	4.03905 (rank : 1123)
Query Neighborhood Hits	1275	Target Neighborhood Hits	370	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

TTC28_HUMAN
NC score	0.006972 (rank : 1266)	θ value	6.88961 (rank : 1232)
Query Neighborhood Hits	1275	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q96AY4, O95928, O95929, Q9NTE4, Q9UG31, Q9UGG5, Q9UPV8, Q9Y3S5	Gene names	TTC28, KIAA1043
Domain Architecture
Description	Tetratricopeptide repeat protein 28 (TPR repeat protein 28).

ANR15_HUMAN
NC score	0.006778 (rank : 1267)	θ value	8.99809 (rank : 1239)
Query Neighborhood Hits	1275	Target Neighborhood Hits	478	Shared Neighborhood Hits	57
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

PI4KB_MOUSE
NC score	0.006755 (rank : 1268)	θ value	0.813845 (rank : 983)
Query Neighborhood Hits	1275	Target Neighborhood Hits	67	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BKC8, Q8C146	Gene names	Pik4cb
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta).

ANR35_HUMAN
NC score	0.006702 (rank : 1269)	θ value	5.27518 (rank : 1141)
Query Neighborhood Hits	1275	Target Neighborhood Hits	784	Shared Neighborhood Hits	74
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

MKL2_MOUSE
NC score	0.006603 (rank : 1270)	θ value	5.27518 (rank : 1168)
Query Neighborhood Hits	1275	Target Neighborhood Hits	269	Shared Neighborhood Hits	59
SwissProt Accessions	P59759	Gene names	Mkl2, Mrtfb
Domain Architecture
Description	MKL/myocardin-like protein 2 (Myocardin-related transcription factor B) (MRTF-B).

SYNE2_HUMAN
NC score	0.006487 (rank : 1271)	θ value	5.27518 (rank : 1181)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1323	Shared Neighborhood Hits	120
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

RPGF1_HUMAN
NC score	0.006340 (rank : 1272)	θ value	0.365318 (rank : 925)
Query Neighborhood Hits	1275	Target Neighborhood Hits	262	Shared Neighborhood Hits	43
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

PI4KB_HUMAN
NC score	0.006139 (rank : 1273)	θ value	2.36792 (rank : 1077)
Query Neighborhood Hits	1275	Target Neighborhood Hits	79	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UBF8, O15096, P78405, Q9BWR6	Gene names	PIK4CB, PI4KB
Domain Architecture
Description	Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) (PtdIns 4-kinase beta) (PI4Kbeta) (PI4K-beta) (NPIK) (PI4K92).

DYN3_HUMAN
NC score	0.006066 (rank : 1274)	θ value	1.06291 (rank : 998)
Query Neighborhood Hits	1275	Target Neighborhood Hits	158	Shared Neighborhood Hits	49
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

CUTL2_MOUSE
NC score	0.006033 (rank : 1275)	θ value	5.27518 (rank : 1154)
Query Neighborhood Hits	1275	Target Neighborhood Hits	771	Shared Neighborhood Hits	118
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

NUP53_HUMAN
NC score	0.005967 (rank : 1276)	θ value	4.03905 (rank : 1131)
Query Neighborhood Hits	1275	Target Neighborhood Hits	156	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

LRBA_HUMAN
NC score	0.005886 (rank : 1277)	θ value	0.62314 (rank : 957)
Query Neighborhood Hits	1275	Target Neighborhood Hits	196	Shared Neighborhood Hits	27
SwissProt Accessions	P50851, Q9H2U3, Q9H2U4	Gene names	LRBA, BGL, CDC4L, LBA
Domain Architecture
Description	Lipopolysaccharide-responsive and beige-like anchor protein (CDC4-like protein) (Beige-like protein).

NRIP1_HUMAN
NC score	0.005882 (rank : 1278)	θ value	2.36792 (rank : 1075)
Query Neighborhood Hits	1275	Target Neighborhood Hits	88	Shared Neighborhood Hits	23
SwissProt Accessions	P48552, Q8IWE8	Gene names	NRIP1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

SOX30_HUMAN
NC score	0.005808 (rank : 1279)	θ value	0.163984 (rank : 891)
Query Neighborhood Hits	1275	Target Neighborhood Hits	305	Shared Neighborhood Hits	65
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

NRBF2_HUMAN
NC score	0.005773 (rank : 1280)	θ value	4.03905 (rank : 1130)
Query Neighborhood Hits	1275	Target Neighborhood Hits	122	Shared Neighborhood Hits	23
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

PPR3A_MOUSE
NC score	0.005655 (rank : 1281)	θ value	6.88961 (rank : 1223)
Query Neighborhood Hits	1275	Target Neighborhood Hits	45	Shared Neighborhood Hits	12
SwissProt Accessions	Q99MR9, Q8BUJ4, Q8BUL0	Gene names	Ppp1r3a, Pp1g
Domain Architecture	No domain graphic available
Description	Protein phosphatase 1 regulatory subunit 3A (Protein phosphatase 1 glycogen-associated regulatory subunit) (Protein phosphatase type-1 glycogen targeting subunit) (RGL).

RD23A_MOUSE
NC score	0.005633 (rank : 1282)	θ value	1.81305 (rank : 1051)
Query Neighborhood Hits	1275	Target Neighborhood Hits	84	Shared Neighborhood Hits	24
SwissProt Accessions	P54726	Gene names	Rad23a, Mhr23a
Domain Architecture
Description	UV excision repair protein RAD23 homolog A (mHR23A).

PF21A_HUMAN
NC score	0.005571 (rank : 1283)	θ value	0.279714 (rank : 909)
Query Neighborhood Hits	1275	Target Neighborhood Hits	303	Shared Neighborhood Hits	42
SwissProt Accessions	Q96BD5, Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9	Gene names	PHF21A, BHC80, KIAA1696
Domain Architecture	No domain graphic available
Description	PHD finger protein 21A (BRAF35-HDAC complex protein BHC80) (BHC80a).

SETB1_HUMAN
NC score	0.005506 (rank : 1284)	θ value	0.279714 (rank : 911)
Query Neighborhood Hits	1275	Target Neighborhood Hits	141	Shared Neighborhood Hits	28
SwissProt Accessions	Q15047, Q96GM9	Gene names	SETDB1, KIAA0067
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET).

CABYR_MOUSE
NC score	0.005403 (rank : 1285)	θ value	6.88961 (rank : 1192)
Query Neighborhood Hits	1275	Target Neighborhood Hits	80	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D424, Q91Y41, Q91Y42	Gene names	Cabyr, Cbp86
Domain Architecture	No domain graphic available
Description	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium- binding protein 86) (Testis-specific calcium-binding protein CBP86).

ZN395_HUMAN
NC score	0.005308 (rank : 1286)	θ value	5.27518 (rank : 1186)
Query Neighborhood Hits	1275	Target Neighborhood Hits	64	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H8N7, Q6F6H2, Q9BY72, Q9NPB2, Q9NS57, Q9NS58, Q9NS59	Gene names	ZNF395, HDBP2, PBF
Domain Architecture	No domain graphic available
Description	Zinc finger protein 395 (Papillomavirus-binding factor) (Papillomavirus regulatory factor 1) (PRF-1) (Huntington disease gene regulatory region-binding protein 2) (HDBP-2) (HD gene regulatory region-binding protein 2) (HD-regulating factor 2) (HDRF-2).

PK1L1_HUMAN
NC score	0.005214 (rank : 1287)	θ value	4.03905 (rank : 1132)
Query Neighborhood Hits	1275	Target Neighborhood Hits	140	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

DAB2_HUMAN
NC score	0.005203 (rank : 1288)	θ value	5.27518 (rank : 1155)
Query Neighborhood Hits	1275	Target Neighborhood Hits	197	Shared Neighborhood Hits	39
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

SI1L3_HUMAN
NC score	0.005202 (rank : 1289)	θ value	6.88961 (rank : 1228)
Query Neighborhood Hits	1275	Target Neighborhood Hits	305	Shared Neighborhood Hits	67
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

DMN_HUMAN
NC score	0.005053 (rank : 1290)	θ value	1.06291 (rank : 997)
Query Neighborhood Hits	1275	Target Neighborhood Hits	690	Shared Neighborhood Hits	93
SwissProt Accessions	O15061	Gene names	DMN, KIAA0353
Domain Architecture
Description	Desmuslin.

JPH1_MOUSE
NC score	0.005052 (rank : 1291)	θ value	1.38821 (rank : 1020)
Query Neighborhood Hits	1275	Target Neighborhood Hits	120	Shared Neighborhood Hits	40
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

SREC2_MOUSE
NC score	0.005039 (rank : 1292)	θ value	4.03905 (rank : 1135)
Query Neighborhood Hits	1275	Target Neighborhood Hits	605	Shared Neighborhood Hits	95
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

SCYBG_HUMAN
NC score	0.005032 (rank : 1293)	θ value	6.88961 (rank : 1226)
Query Neighborhood Hits	1275	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H2A7, Q8TC80, Q96K63, Q9BXD6, Q9H2F6	Gene names	CXCL16, SCYB16, SRPSOX
Domain Architecture	No domain graphic available
Description	Small inducible cytokine B16 precursor (Transmembrane chemokine CXCL16) (SR-PSOX) (Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein).

CJ006_HUMAN
NC score	0.005029 (rank : 1294)	θ value	2.36792 (rank : 1063)
Query Neighborhood Hits	1275	Target Neighborhood Hits	122	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IX21, Q5W0L8, Q9NPE8	Gene names	C10orf6
Domain Architecture	No domain graphic available
Description	Protein C10orf6.

NRX2B_HUMAN
NC score	0.004996 (rank : 1295)	θ value	0.813845 (rank : 978)
Query Neighborhood Hits	1275	Target Neighborhood Hits	481	Shared Neighborhood Hits	70
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

ATF6B_HUMAN
NC score	0.004922 (rank : 1296)	θ value	2.36792 (rank : 1059)
Query Neighborhood Hits	1275	Target Neighborhood Hits	122	Shared Neighborhood Hits	25
SwissProt Accessions	Q99941, Q13269, Q14343, Q14345, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0	Gene names	CREBL1, G13
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp) (Protein G13).

ZCHC7_HUMAN
NC score	0.004857 (rank : 1297)	θ value	4.03905 (rank : 1140)
Query Neighborhood Hits	1275	Target Neighborhood Hits	73	Shared Neighborhood Hits	19
SwissProt Accessions	Q8N3Z6, Q5T0Q8, Q5T0Q9, Q5T0R0, Q8N2M1, Q8N4J2, Q8TBK8, Q9H648, Q9P0F0	Gene names	ZCCHC7
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 7.

MMAC_HUMAN
NC score	0.004753 (rank : 1298)	θ value	4.03905 (rank : 1124)
Query Neighborhood Hits	1275	Target Neighborhood Hits	76	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y4U1, Q5T157, Q9BRQ7	Gene names	MMACHC
Domain Architecture	No domain graphic available
Description	Methylmalonic aciduria and homocystinuria type C protein.

NOL7_HUMAN
NC score	0.004737 (rank : 1299)	θ value	5.27518 (rank : 1170)
Query Neighborhood Hits	1275	Target Neighborhood Hits	39	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UMY1, Q5T297, Q9Y3U7	Gene names	NOL7, C6orf90, NOP27
Domain Architecture	No domain graphic available
Description	Nucleolar protein 7 (Nucleolar protein of 27 kDa).

CEBPD_HUMAN
NC score	0.004734 (rank : 1300)	θ value	5.27518 (rank : 1150)
Query Neighborhood Hits	1275	Target Neighborhood Hits	135	Shared Neighborhood Hits	28
SwissProt Accessions	P49716, Q14937	Gene names	CEBPD
Domain Architecture
Description	CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF- IL6-beta) (NF-IL6-beta).

FOXP2_MOUSE
NC score	0.004710 (rank : 1301)	θ value	1.81305 (rank : 1035)
Query Neighborhood Hits	1275	Target Neighborhood Hits	366	Shared Neighborhood Hits	60
SwissProt Accessions	P58463, Q6PD37, Q8C4F0, Q8R441	Gene names	Foxp2
Domain Architecture
Description	Forkhead box protein P2.

WHRN_MOUSE
NC score	0.004662 (rank : 1302)	θ value	6.88961 (rank : 1235)
Query Neighborhood Hits	1275	Target Neighborhood Hits	412	Shared Neighborhood Hits	71
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

4ET_MOUSE
NC score	0.004650 (rank : 1303)	θ value	4.03905 (rank : 1109)
Query Neighborhood Hits	1275	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EST3, Q9CSS3	Gene names	Eif4enif1, Clast4
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4E transporter (eIF4E transporter) (4E-T) (Eukaryotic translation initiation factor 4E nuclear import factor 1).

EXO1_MOUSE
NC score	0.004538 (rank : 1304)	θ value	3.0926 (rank : 1094)
Query Neighborhood Hits	1275	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	Q9QZ11, Q3TLM4, Q923A5	Gene names	Exo1
Domain Architecture	No domain graphic available
Description	Exonuclease 1 (EC 3.1.-.-) (mExo1) (Exonuclease I).

LPIN3_MOUSE
NC score	0.004436 (rank : 1305)	θ value	0.47712 (rank : 935)
Query Neighborhood Hits	1275	Target Neighborhood Hits	52	Shared Neighborhood Hits	8
SwissProt Accessions	Q99PI4, Q3TQ75, Q8C7R9	Gene names	Lpin3
Domain Architecture
Description	Lipin-3.

FOXP2_HUMAN
NC score	0.004230 (rank : 1306)	θ value	6.88961 (rank : 1200)
Query Neighborhood Hits	1275	Target Neighborhood Hits	366	Shared Neighborhood Hits	60
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

P66B_HUMAN
NC score	0.004201 (rank : 1307)	θ value	6.88961 (rank : 1215)
Query Neighborhood Hits	1275	Target Neighborhood Hits	61	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WXI9, Q7LG68, Q9ULS0	Gene names	GATAD2B, KIAA1150
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 beta (p66/p68) (GATA zinc finger domain- containing protein 2B).

FCRLA_HUMAN
NC score	0.004180 (rank : 1308)	θ value	0.62314 (rank : 954)
Query Neighborhood Hits	1275	Target Neighborhood Hits	135	Shared Neighborhood Hits	22
SwissProt Accessions	Q7L513, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXB0, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57	Gene names	FCRLA, FCRL, FCRL1, FCRLM1, FCRX, FREB
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

PO6F1_MOUSE
NC score	0.004086 (rank : 1309)	θ value	0.0736092 (rank : 869)
Query Neighborhood Hits	1275	Target Neighborhood Hits	581	Shared Neighborhood Hits	92
SwissProt Accessions	Q07916, Q91XK3	Gene names	Pou6f1, Emb
Domain Architecture
Description	POU domain, class 6, transcription factor 1 (Octamer-binding transcription factor EMB) (Transcription regulatory protein MCP-1).

P66B_MOUSE
NC score	0.004011 (rank : 1310)	θ value	8.99809 (rank : 1258)
Query Neighborhood Hits	1275	Target Neighborhood Hits	64	Shared Neighborhood Hits	14
SwissProt Accessions	Q8VHR5, Q8C9Q3	Gene names	Gatad2b
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 beta (p66/p68) (GATA zinc finger domain- containing protein 2B).

NCTR2_HUMAN
NC score	0.003907 (rank : 1311)	θ value	6.88961 (rank : 1212)
Query Neighborhood Hits	1275	Target Neighborhood Hits	99	Shared Neighborhood Hits	19
SwissProt Accessions	O95944, Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2	Gene names	NCR2, LY95
Domain Architecture
Description	Natural cytotoxicity triggering receptor 2 precursor (Natural killer cell p44-related protein) (NKp44) (NK-p44) (NK cell-activating receptor) (Lymphocyte antigen 95 homolog) (CD336 antigen).

RTEL1_HUMAN
NC score	0.003835 (rank : 1312)	θ value	3.0926 (rank : 1106)
Query Neighborhood Hits	1275	Target Neighborhood Hits	116	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZ71, Q5JTV4, Q9BW37, Q9H402, Q9H4X6, Q9NX25, Q9NZ73, Q9UPR4, Q9Y4R6	Gene names	RTEL1, C20orf41, KIAA1088, NHL
Domain Architecture
Description	Regulator of telomere elongation helicase 1 (EC 3.6.1.-) (Helicase- like protein NHL).

PDLI1_MOUSE
NC score	0.003630 (rank : 1313)	θ value	8.99809 (rank : 1260)
Query Neighborhood Hits	1275	Target Neighborhood Hits	213	Shared Neighborhood Hits	20
SwissProt Accessions	O70400, Q99K93	Gene names	Pdlim1, Clim1
Domain Architecture
Description	PDZ and LIM domain protein 1 (Elfin) (LIM domain protein CLP-36) (C- terminal LIM domain protein 1).

CNOT4_MOUSE
NC score	0.003402 (rank : 1314)	θ value	8.99809 (rank : 1245)
Query Neighborhood Hits	1275	Target Neighborhood Hits	277	Shared Neighborhood Hits	52
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

JOSD3_MOUSE
NC score	0.003398 (rank : 1315)	θ value	6.88961 (rank : 1206)
Query Neighborhood Hits	1275	Target Neighborhood Hits	31	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D4V4, Q149X7, Q8C7I5, Q9CZG0, Q9D5U6	Gene names	Josd3
Domain Architecture	No domain graphic available
Description	Protein JOSD3.

K1024_MOUSE
NC score	0.003289 (rank : 1316)	θ value	4.03905 (rank : 1119)
Query Neighborhood Hits	1275	Target Neighborhood Hits	57	Shared Neighborhood Hits	10
SwissProt Accessions	Q8K3V7, Q69ZS9	Gene names	Kiaa1024
Domain Architecture
Description	UPF0258 protein KIAA1024 (Protein DD1).

LYPD3_HUMAN
NC score	0.003039 (rank : 1317)	θ value	5.27518 (rank : 1167)
Query Neighborhood Hits	1275	Target Neighborhood Hits	43	Shared Neighborhood Hits	10
SwissProt Accessions	O95274, Q9UJ74	Gene names	LYPD3, C4.4A
Domain Architecture	No domain graphic available
Description	Ly6/PLAUR domain-containing protein 3 precursor (GPI-anchored metastasis-associated protein C4.4A homolog) (Matrigel-induced gene C4 protein) (MIG-C4).

CCM2_MOUSE
NC score	0.002774 (rank : 1318)	θ value	5.27518 (rank : 1149)
Query Neighborhood Hits	1275	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K2Y9	Gene names	Ccm2, Osm
Domain Architecture	No domain graphic available
Description	Malcavernin (Cerebral cavernous malformations protein 2 homolog) (Osmosensing scaffold for MEKK3).

EMIL2_MOUSE
NC score	0.002753 (rank : 1319)	θ value	1.38821 (rank : 1015)
Query Neighborhood Hits	1275	Target Neighborhood Hits	485	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K482	Gene names	Emilin2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Basilin).

RHBD3_MOUSE
NC score	0.002750 (rank : 1320)	θ value	5.27518 (rank : 1175)
Query Neighborhood Hits	1275	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BP97, Q3U0Y4, Q5SUT5, Q5SUT6, Q5SUT7	Gene names	Rhbdd3
Domain Architecture	No domain graphic available
Description	Rhomboid domain-containing protein 3.

RAD9B_MOUSE
NC score	0.002660 (rank : 1321)	θ value	3.0926 (rank : 1105)
Query Neighborhood Hits	1275	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q6WBX7	Gene names	Rad9b
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint control protein RAD9B homolog (RAD9 homolog B) (mRAD9B).

STX18_HUMAN
NC score	0.002641 (rank : 1322)	θ value	8.99809 (rank : 1267)
Query Neighborhood Hits	1275	Target Neighborhood Hits	225	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P2W9, Q596L3, Q5TZP5	Gene names	STX18, GIG9
Domain Architecture	No domain graphic available
Description	Syntaxin-18 (Growth-inhibiting gene 9 protein).

NUMBL_MOUSE
NC score	0.002623 (rank : 1323)	θ value	6.88961 (rank : 1214)
Query Neighborhood Hits	1275	Target Neighborhood Hits	147	Shared Neighborhood Hits	36
SwissProt Accessions	O08919, Q6NVG8	Gene names	Numbl, Nbl
Domain Architecture
Description	Numb-like protein.

TTLL7_HUMAN
NC score	0.002578 (rank : 1324)	θ value	8.99809 (rank : 1271)
Query Neighborhood Hits	1275	Target Neighborhood Hits	95	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZT98, Q5TAX8, Q5TAX9, Q6P990, Q86YS1, Q9H5U4	Gene names	TTLL7
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 7 (Protein NYD-SP30).

RGL1_HUMAN
NC score	0.002546 (rank : 1325)	θ value	0.813845 (rank : 985)
Query Neighborhood Hits	1275	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

CCM2_HUMAN
NC score	0.002526 (rank : 1326)	θ value	6.88961 (rank : 1193)
Query Neighborhood Hits	1275	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BSQ5, Q71RE5, Q8TAT4	Gene names	CCM2, C7orf22
Domain Architecture	No domain graphic available
Description	Malcavernin (Cerebral cavernous malformations 2 protein).

PO6F2_HUMAN
NC score	0.002507 (rank : 1327)	θ value	5.27518 (rank : 1173)
Query Neighborhood Hits	1275	Target Neighborhood Hits	618	Shared Neighborhood Hits	118
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

XKR7_MOUSE
NC score	0.002491 (rank : 1328)	θ value	2.36792 (rank : 1084)
Query Neighborhood Hits	1275	Target Neighborhood Hits	146	Shared Neighborhood Hits	23
SwissProt Accessions	Q5GH64	Gene names	Xkr7, Xrg7
Domain Architecture	No domain graphic available
Description	XK-related protein 7.

TTLL4_MOUSE
NC score	0.002419 (rank : 1329)	θ value	5.27518 (rank : 1184)
Query Neighborhood Hits	1275	Target Neighborhood Hits	103	Shared Neighborhood Hits	26
SwissProt Accessions	Q80UG8, Q5U4C4	Gene names	Ttll4, Kiaa0173
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 4.

ILDR1_HUMAN
NC score	0.002400 (rank : 1330)	θ value	5.27518 (rank : 1159)
Query Neighborhood Hits	1275	Target Neighborhood Hits	31	Shared Neighborhood Hits	7
SwissProt Accessions	Q86SU0, Q6ZP61, Q7Z578	Gene names	ILDR1
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain-containing receptor 1 precursor.

IP3KA_HUMAN
NC score	0.002375 (rank : 1331)	θ value	5.27518 (rank : 1160)
Query Neighborhood Hits	1275	Target Neighborhood Hits	60	Shared Neighborhood Hits	10
SwissProt Accessions	P23677, Q8TAN3	Gene names	ITPKA
Domain Architecture
Description	Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase A) (IP3K A) (IP3 3-kinase A).

UTX_HUMAN
NC score	0.002292 (rank : 1332)	θ value	6.88961 (rank : 1234)
Query Neighborhood Hits	1275	Target Neighborhood Hits	161	Shared Neighborhood Hits	25
SwissProt Accessions	O15550	Gene names	UTX
Domain Architecture
Description	Ubiquitously transcribed X chromosome tetratricopeptide repeat protein (Ubiquitously transcribed TPR protein on the X chromosome).

RHG06_HUMAN
NC score	0.002109 (rank : 1333)	θ value	0.21417 (rank : 895)
Query Neighborhood Hits	1275	Target Neighborhood Hits	114	Shared Neighborhood Hits	17
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
NC score	0.002061 (rank : 1334)	θ value	0.47712 (rank : 937)
Query Neighborhood Hits	1275	Target Neighborhood Hits	105	Shared Neighborhood Hits	11
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

GP156_MOUSE
NC score	0.002005 (rank : 1335)	θ value	6.88961 (rank : 1203)
Query Neighborhood Hits	1275	Target Neighborhood Hits	95	Shared Neighborhood Hits	18
SwissProt Accessions	Q6PCP7, Q8K452	Gene names	Gpr156, Gababl
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 156 (GABAB-related G-protein coupled receptor).

RGL1_MOUSE
NC score	0.001985 (rank : 1336)	θ value	2.36792 (rank : 1079)
Query Neighborhood Hits	1275	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

FA13C_MOUSE
NC score	0.001896 (rank : 1337)	θ value	6.88961 (rank : 1198)
Query Neighborhood Hits	1275	Target Neighborhood Hits	79	Shared Neighborhood Hits	20
SwissProt Accessions	Q9DBR2	Gene names	Fam13c1
Domain Architecture	No domain graphic available
Description	Protein FAM13C1.

K0226_MOUSE
NC score	0.001883 (rank : 1338)	θ value	5.27518 (rank : 1161)
Query Neighborhood Hits	1275	Target Neighborhood Hits	59	Shared Neighborhood Hits	10
SwissProt Accessions	Q80U62, Q3TAX3, Q3TDF7, Q3TDU2, Q6P9T7, Q6PG18, Q8BMP7, Q8BY22	Gene names	Kiaa0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

CECR2_HUMAN
NC score	0.001863 (rank : 1339)	θ value	8.99809 (rank : 1243)
Query Neighborhood Hits	1275	Target Neighborhood Hits	543	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

NFAT5_MOUSE
NC score	0.001840 (rank : 1340)	θ value	6.88961 (rank : 1213)
Query Neighborhood Hits	1275	Target Neighborhood Hits	162	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WV30	Gene names	Nfat5
Domain Architecture
Description	Nuclear factor of activated T-cells 5 (T cell transcription factor NFAT5) (NF-AT5) (Rel domain-containing transcription factor NFAT5).

YTHD2_HUMAN
NC score	0.001714 (rank : 1341)	θ value	2.36792 (rank : 1085)
Query Neighborhood Hits	1275	Target Neighborhood Hits	89	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y5A9, Q5VSZ9, Q8TDH0, Q9BUJ5	Gene names	YTHDF2, HGRG8
Domain Architecture
Description	YTH domain family protein 2 (High-glucose-regulated protein 8) (NY- REN-2 antigen) (CLL-associated antigen KW-14).

APBB2_MOUSE
NC score	0.001704 (rank : 1342)	θ value	5.27518 (rank : 1142)
Query Neighborhood Hits	1275	Target Neighborhood Hits	88	Shared Neighborhood Hits	26
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

RC3H1_HUMAN
NC score	0.001515 (rank : 1343)	θ value	5.27518 (rank : 1174)
Query Neighborhood Hits	1275	Target Neighborhood Hits	433	Shared Neighborhood Hits	64
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

LIPA4_HUMAN
NC score	0.001450 (rank : 1344)	θ value	1.81305 (rank : 1044)
Query Neighborhood Hits	1275	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	O75335, O94971	Gene names	PPFIA4, KIAA0897
Domain Architecture
Description	Liprin-alpha-4 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4) (PTPRF-interacting protein alpha-4).

CEBPE_HUMAN
NC score	0.001319 (rank : 1345)	θ value	5.27518 (rank : 1151)
Query Neighborhood Hits	1275	Target Neighborhood Hits	236	Shared Neighborhood Hits	30
SwissProt Accessions	Q15744, Q15745, Q8IYI2, Q99803	Gene names	CEBPE
Domain Architecture
Description	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon).

ELK4_HUMAN
NC score	0.001294 (rank : 1346)	θ value	0.47712 (rank : 932)
Query Neighborhood Hits	1275	Target Neighborhood Hits	184	Shared Neighborhood Hits	43
SwissProt Accessions	P28324, P28323	Gene names	ELK4, SAP1
Domain Architecture
Description	ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1).

FOXP1_MOUSE
NC score	0.001290 (rank : 1347)	θ value	2.36792 (rank : 1066)
Query Neighborhood Hits	1275	Target Neighborhood Hits	241	Shared Neighborhood Hits	36
SwissProt Accessions	P58462	Gene names	Foxp1
Domain Architecture
Description	Forkhead box protein P1 (Forkhead-related transcription factor 1).

CAP1_MOUSE
NC score	0.001106 (rank : 1348)	θ value	5.27518 (rank : 1147)
Query Neighborhood Hits	1275	Target Neighborhood Hits	46	Shared Neighborhood Hits	10
SwissProt Accessions	P40124	Gene names	Cap1, Cap
Domain Architecture
Description	Adenylyl cyclase-associated protein 1 (CAP 1).

TM55B_MOUSE
NC score	0.001090 (rank : 1349)	θ value	5.27518 (rank : 1182)
Query Neighborhood Hits	1275	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	Q3TWL2	Gene names	Tmem55b
Domain Architecture	No domain graphic available
Description	Transmembrane protein 55B (EC 3.1.3.-) (Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (PtdIns-4,5-P2 4-Ptase I).

EDRF1_HUMAN
NC score	0.001040 (rank : 1350)	θ value	8.99809 (rank : 1247)
Query Neighborhood Hits	1275	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q3B7T1, Q4G190, Q8IZ74, Q9Y3W4	Gene names	EDRF1, C10orf137
Domain Architecture	No domain graphic available
Description	Erythroid differentiation-related factor 1.

NBEA_HUMAN
NC score	0.001020 (rank : 1351)	θ value	3.0926 (rank : 1101)
Query Neighborhood Hits	1275	Target Neighborhood Hits	186	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

RGS12_HUMAN
NC score	0.000678 (rank : 1352)	θ value	2.36792 (rank : 1080)
Query Neighborhood Hits	1275	Target Neighborhood Hits	333	Shared Neighborhood Hits	50
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

HDAC7_MOUSE
NC score	0.000662 (rank : 1353)	θ value	1.81305 (rank : 1039)
Query Neighborhood Hits	1275	Target Neighborhood Hits	85	Shared Neighborhood Hits	20
SwissProt Accessions	Q8C2B3, Q8C2C9, Q8C8X4, Q8CB80, Q8CDA3, Q9JL72	Gene names	Hdac7a, Hdac7
Domain Architecture
Description	Histone deacetylase 7a (HD7a).

DMRT1_MOUSE
NC score	0.000610 (rank : 1354)	θ value	6.88961 (rank : 1196)
Query Neighborhood Hits	1275	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZ59, Q9QZ37, Q9QZA4	Gene names	Dmrt1
Domain Architecture
Description	Doublesex- and mab-3-related transcription factor 1.

FANCM_HUMAN
NC score	0.000299 (rank : 1355)	θ value	0.62314 (rank : 952)
Query Neighborhood Hits	1275	Target Neighborhood Hits	210	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

EYA3_MOUSE
NC score	0.000002 (rank : 1356)	θ value	5.27518 (rank : 1157)
Query Neighborhood Hits	1275	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	P97480, P97768	Gene names	Eya3
Domain Architecture
Description	Eyes absent homolog 3 (EC 3.1.3.48).

NOVA1_HUMAN
NC score	-0.000003 (rank : 1357)	θ value	4.03905 (rank : 1129)
Query Neighborhood Hits	1275	Target Neighborhood Hits	50	Shared Neighborhood Hits	7
SwissProt Accessions	P51513	Gene names	NOVA1
Domain Architecture
Description	RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1).

LAMP1_HUMAN
NC score	-0.000065 (rank : 1358)	θ value	8.99809 (rank : 1253)
Query Neighborhood Hits	1275	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	P11279	Gene names	LAMP1
Domain Architecture
Description	Lysosome-associated membrane glycoprotein 1 precursor (LAMP-1) (CD107a antigen).

NRX2A_HUMAN
NC score	-0.000157 (rank : 1359)	θ value	0.813845 (rank : 977)
Query Neighborhood Hits	1275	Target Neighborhood Hits	614	Shared Neighborhood Hits	78
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

B3A3_MOUSE
NC score	-0.000194 (rank : 1360)	θ value	5.27518 (rank : 1143)
Query Neighborhood Hits	1275	Target Neighborhood Hits	112	Shared Neighborhood Hits	26
SwissProt Accessions	P16283	Gene names	Slc4a3, Ae3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3).

CLMN_MOUSE
NC score	-0.000198 (rank : 1361)	θ value	5.27518 (rank : 1153)
Query Neighborhood Hits	1275	Target Neighborhood Hits	180	Shared Neighborhood Hits	28
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

PRKDC_MOUSE
NC score	-0.000229 (rank : 1362)	θ value	4.03905 (rank : 1133)
Query Neighborhood Hits	1275	Target Neighborhood Hits	92	Shared Neighborhood Hits	16
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

STYX_HUMAN
NC score	-0.000257 (rank : 1363)	θ value	0.62314 (rank : 963)
Query Neighborhood Hits	1275	Target Neighborhood Hits	60	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WUJ0, Q99850	Gene names	STYX
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein).

YAP1_MOUSE
NC score	-0.000337 (rank : 1364)	θ value	8.99809 (rank : 1275)
Query Neighborhood Hits	1275	Target Neighborhood Hits	96	Shared Neighborhood Hits	24
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

UBIP1_MOUSE
NC score	-0.000436 (rank : 1365)	θ value	8.99809 (rank : 1274)
Query Neighborhood Hits	1275	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q811S7, Q3UPR3, Q3US11, Q60786, Q8C514	Gene names	Ubp1, Cp2b, Nf2d9
Domain Architecture	No domain graphic available
Description	Upstream-binding protein 1 (Nuclear factor 2d9) (NF2d9).

SL9A5_HUMAN
NC score	-0.000525 (rank : 1366)	θ value	5.27518 (rank : 1178)
Query Neighborhood Hits	1275	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	Q14940, Q9Y626	Gene names	SLC9A5, NHE5
Domain Architecture
Description	Sodium/hydrogen exchanger 5 (Na(+)/H(+) exchanger 5) (NHE-5) (Solute carrier family 9 member 5).

TCF7_MOUSE
NC score	-0.000635 (rank : 1367)	θ value	1.81305 (rank : 1054)
Query Neighborhood Hits	1275	Target Neighborhood Hits	277	Shared Neighborhood Hits	30
SwissProt Accessions	Q00417	Gene names	Tcf7, Tcf-1, Tcf1
Domain Architecture
Description	Transcription factor 7 (T-cell-specific transcription factor 1) (TCF- 1) (T-cell factor 1).

STYX_MOUSE
NC score	-0.000700 (rank : 1368)	θ value	1.06291 (rank : 1006)
Query Neighborhood Hits	1275	Target Neighborhood Hits	62	Shared Neighborhood Hits	3
SwissProt Accessions	Q60969, Q3TMA3, Q60970, Q9DCF8	Gene names	Styx
Domain Architecture
Description	Serine/threonine/tyrosine-interacting protein (Protein tyrosine phosphatase-like protein) (Phosphoserine/threonine/tyrosine interaction protein).

G3BP2_HUMAN
NC score	-0.000942 (rank : 1369)	θ value	4.03905 (rank : 1117)
Query Neighborhood Hits	1275	Target Neighborhood Hits	260	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

SFRS6_HUMAN
NC score	-0.001527 (rank : 1370)	θ value	5.27518 (rank : 1177)
Query Neighborhood Hits	1275	Target Neighborhood Hits	247	Shared Neighborhood Hits	37
SwissProt Accessions	Q13247, Q13244, Q13245, Q96J06, Q9UJB8, Q9Y3N7	Gene names	SFRS6, SRP55
Domain Architecture
Description	Splicing factor, arginine/serine-rich 6 (Pre-mRNA-splicing factor SRP55).

ADA12_MOUSE
NC score	-0.001538 (rank : 1371)	θ value	0.62314 (rank : 945)
Query Neighborhood Hits	1275	Target Neighborhood Hits	474	Shared Neighborhood Hits	83
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

FBXL6_HUMAN
NC score	-0.001701 (rank : 1372)	θ value	8.99809 (rank : 1250)
Query Neighborhood Hits	1275	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N531, Q9H5W9, Q9UKC7	Gene names	FBXL6, FBL6
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A).

GP1BA_HUMAN
NC score	-0.002022 (rank : 1373)	θ value	0.163984 (rank : 888)
Query Neighborhood Hits	1275	Target Neighborhood Hits	407	Shared Neighborhood Hits	68
SwissProt Accessions	P07359, Q14441, Q16469, Q8N1F3, Q8NG39, Q9HDC7, Q9UEK1, Q9UQS4	Gene names	GP1BA
Domain Architecture
Description	Platelet glycoprotein Ib alpha chain precursor (Glycoprotein Ibalpha) (GP-Ib alpha) (GPIbA) (GPIb-alpha) (Antigen CD42b-alpha) (CD42b antigen) [Contains: Glycocalicin].

LRC46_HUMAN
NC score	-0.002165 (rank : 1374)	θ value	3.0926 (rank : 1097)
Query Neighborhood Hits	1275	Target Neighborhood Hits	181	Shared Neighborhood Hits	15
SwissProt Accessions	Q96FV0	Gene names	LRRC46
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 46.

NOTC2_HUMAN
NC score	-0.002300 (rank : 1375)	θ value	1.06291 (rank : 1001)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1113	Shared Neighborhood Hits	121
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

PGCA_HUMAN
NC score	-0.002567 (rank : 1376)	θ value	6.88961 (rank : 1219)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	102
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

SUSD4_MOUSE
NC score	-0.002845 (rank : 1377)	θ value	2.36792 (rank : 1083)
Query Neighborhood Hits	1275	Target Neighborhood Hits	122	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BH32, Q8VC43	Gene names	Susd4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

AGRIN_HUMAN
NC score	-0.003032 (rank : 1378)	θ value	3.0926 (rank : 1087)
Query Neighborhood Hits	1275	Target Neighborhood Hits	582	Shared Neighborhood Hits	65
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

FZD3_MOUSE
NC score	-0.003073 (rank : 1379)	θ value	1.81305 (rank : 1037)
Query Neighborhood Hits	1275	Target Neighborhood Hits	75	Shared Neighborhood Hits	5
SwissProt Accessions	Q61086	Gene names	Fzd3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (mFz3).

KCNQ5_HUMAN
NC score	-0.003132 (rank : 1380)	θ value	5.27518 (rank : 1163)
Query Neighborhood Hits	1275	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

CAC1A_MOUSE
NC score	-0.003222 (rank : 1381)	θ value	5.27518 (rank : 1146)
Query Neighborhood Hits	1275	Target Neighborhood Hits	267	Shared Neighborhood Hits	46
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

FZD3_HUMAN
NC score	-0.003332 (rank : 1382)	θ value	1.81305 (rank : 1036)
Query Neighborhood Hits	1275	Target Neighborhood Hits	74	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NPG1	Gene names	FZD3
Domain Architecture
Description	Frizzled-3 precursor (Fz-3) (hFz3).

NKG2C_HUMAN
NC score	-0.003393 (rank : 1383)	θ value	0.813845 (rank : 976)
Query Neighborhood Hits	1275	Target Neighborhood Hits	100	Shared Neighborhood Hits	5
SwissProt Accessions	P26717, O43802, Q9NR42	Gene names	KLRC2, NKG2C
Domain Architecture
Description	NKG2-C type II integral membrane protein (NKG2-C-activating NK receptor) (NK cell receptor C) (CD159c antigen).

ANGL1_MOUSE
NC score	-0.003552 (rank : 1384)	θ value	0.62314 (rank : 946)
Query Neighborhood Hits	1275	Target Neighborhood Hits	102	Shared Neighborhood Hits	10
SwissProt Accessions	Q640P2, Q3UQL1, Q9CZ81	Gene names	Angptl1
Domain Architecture	No domain graphic available
Description	Angiopoietin-related protein 1 precursor (Angiopoietin-like 1).

WDHD1_MOUSE
NC score	-0.003892 (rank : 1385)	θ value	0.125558 (rank : 883)
Query Neighborhood Hits	1275	Target Neighborhood Hits	414	Shared Neighborhood Hits	31
SwissProt Accessions	P59328, Q6P408	Gene names	Wdhd1, And1
Domain Architecture	No domain graphic available
Description	WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA- binding protein 1) (And-1).

KCNH7_HUMAN
NC score	-0.004053 (rank : 1386)	θ value	8.99809 (rank : 1252)
Query Neighborhood Hits	1275	Target Neighborhood Hits	107	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NS40	Gene names	KCNH7, ERG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 7 (Voltage-gated potassium channel subunit Kv11.3) (Ether-a-go-go-related gene potassium channel 3) (HERG-3) (Ether-a-go-go-related protein 3) (Eag- related protein 3).

NKG2E_HUMAN
NC score	-0.004766 (rank : 1387)	θ value	8.99809 (rank : 1256)
Query Neighborhood Hits	1275	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q07444, Q96RL0, Q9UP04	Gene names	KLRC3, NKG2E
Domain Architecture
Description	NKG2-E type II integral membrane protein (NKG2-E-activating NK receptor) (NK cell receptor E).

NOTC2_MOUSE
NC score	-0.004795 (rank : 1388)	θ value	0.365318 (rank : 921)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1069	Shared Neighborhood Hits	94
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

AMFR2_HUMAN
NC score	-0.004878 (rank : 1389)	θ value	3.0926 (rank : 1089)
Query Neighborhood Hits	1275	Target Neighborhood Hits	219	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

HNF3G_MOUSE
NC score	-0.004958 (rank : 1390)	θ value	0.21417 (rank : 893)
Query Neighborhood Hits	1275	Target Neighborhood Hits	103	Shared Neighborhood Hits	11
SwissProt Accessions	P35584	Gene names	Foxa3, Hnf3g, Tcf-3g, Tcf3g
Domain Architecture
Description	Hepatocyte nuclear factor 3-gamma (HNF-3G) (Forkhead box protein A3).

SEM6D_HUMAN
NC score	-0.005083 (rank : 1391)	θ value	8.99809 (rank : 1264)
Query Neighborhood Hits	1275	Target Neighborhood Hits	169	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NFY4, Q8NFY3, Q8NFY5, Q8NFY6, Q8NFY7, Q9P249	Gene names	SEMA6D, KIAA1479
Domain Architecture	No domain graphic available
Description	Semaphorin-6D precursor.

H2AW_HUMAN
NC score	-0.005115 (rank : 1392)	θ value	8.99809 (rank : 1251)
Query Neighborhood Hits	1275	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9P0M6, Q5SQT2	Gene names	H2AFY2, MACROH2A2
Domain Architecture
Description	Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2).

RBP2_MOUSE
NC score	-0.005204 (rank : 1393)	θ value	6.88961 (rank : 1225)
Query Neighborhood Hits	1275	Target Neighborhood Hits	232	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ERU9, Q61992, Q8C9K9	Gene names	Ranbp2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2 (RanBP2).

IC1_MOUSE
NC score	-0.005442 (rank : 1394)	θ value	2.36792 (rank : 1067)
Query Neighborhood Hits	1275	Target Neighborhood Hits	164	Shared Neighborhood Hits	25
SwissProt Accessions	P97290, O88330, Q99M43, Q9QX09	Gene names	Serping1, C1nh
Domain Architecture
Description	Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh) (C1 esterase inhibitor) (C1-inhibiting factor).

ZN409_HUMAN
NC score	-0.005618 (rank : 1395)	θ value	0.365318 (rank : 927)
Query Neighborhood Hits	1275	Target Neighborhood Hits	842	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPU6	Gene names	ZNF409, KIAA1056
Domain Architecture	No domain graphic available
Description	Zinc finger protein 409.

TSH2_HUMAN
NC score	-0.006255 (rank : 1396)	θ value	8.99809 (rank : 1270)
Query Neighborhood Hits	1275	Target Neighborhood Hits	479	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NRE2, Q4VXM4, Q6N003, Q8N260	Gene names	TSHZ2, C20orf17, TSH2, ZNF218
Domain Architecture	No domain graphic available
Description	Teashirt homolog 2 (Zinc finger protein 218) (Ovarian cancer-related protein 10-2) (OVC10-2).

FBLN2_MOUSE
NC score	-0.006301 (rank : 1397)	θ value	0.62314 (rank : 953)
Query Neighborhood Hits	1275	Target Neighborhood Hits	505	Shared Neighborhood Hits	59
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

ADA15_MOUSE
NC score	-0.006359 (rank : 1398)	θ value	6.88961 (rank : 1188)
Query Neighborhood Hits	1275	Target Neighborhood Hits	324	Shared Neighborhood Hits	39
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

PTN13_MOUSE
NC score	-0.006372 (rank : 1399)	θ value	0.62314 (rank : 961)
Query Neighborhood Hits	1275	Target Neighborhood Hits	426	Shared Neighborhood Hits	46
SwissProt Accessions	Q64512, Q61494, Q62135, Q64499	Gene names	Ptpn13, Ptp14
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Protein tyrosine phosphatase PTP-BL) (Protein-tyrosine phosphatase RIP) (protein tyrosine phosphatase DPZPTP) (PTP36).

ATBF1_MOUSE
NC score	-0.006442 (rank : 1400)	θ value	0.813845 (rank : 966)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1841	Shared Neighborhood Hits	214
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

SLIK4_MOUSE
NC score	-0.008918 (rank : 1401)	θ value	1.38821 (rank : 1025)
Query Neighborhood Hits	1275	Target Neighborhood Hits	292	Shared Neighborhood Hits	17
SwissProt Accessions	Q810B8, Q8BL56, Q8BWB0, Q8BYG4, Q8C056	Gene names	Slitrk4
Domain Architecture
Description	SLIT and NTRK-like protein 4 precursor.

SLIK4_HUMAN
NC score	-0.009320 (rank : 1402)	θ value	6.88961 (rank : 1229)
Query Neighborhood Hits	1275	Target Neighborhood Hits	287	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IW52, Q8TCM8, Q96DL3	Gene names	SLITRK4
Domain Architecture
Description	SLIT and NTRK-like protein 4 precursor.

PC11Y_HUMAN
NC score	-0.010921 (rank : 1403)	θ value	8.99809 (rank : 1259)
Query Neighborhood Hits	1275	Target Neighborhood Hits	205	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZA8, Q70LR6, Q70LR8, Q70LS0, Q70LS1, Q70LS2, Q70LS3, Q70LS4, Q70LS5, Q8WY34, Q9BZA9, Q9H4E1	Gene names	PCDH11Y, PCDH11, PCDH22, PCDHY
Domain Architecture	No domain graphic available
Description	Protocadherin-11 Y-linked precursor (Protocadherin-11) (Protocadherin- 22) (Protocadherin on the Y chromosome) (PCDH-Y) (Protocadherin prostate cancer) (Protocadherin-PC).

PK1IP_MOUSE
NC score	-0.012292 (rank : 1404)	θ value	6.88961 (rank : 1222)
Query Neighborhood Hits	1275	Target Neighborhood Hits	313	Shared Neighborhood Hits	11
SwissProt Accessions	Q9DCE5, Q3UBK7, Q80UT4, Q8C5N6, Q923K2, Q9D3E9	Gene names	Pak1ip1
Domain Architecture	No domain graphic available
Description	p21-activated protein kinase-interacting protein 1 (PAK1-interacting protein 1) (Putative PAK inhibitor Skb15).

PAX3_MOUSE
NC score	-0.012399 (rank : 1405)	θ value	5.27518 (rank : 1171)
Query Neighborhood Hits	1275	Target Neighborhood Hits	478	Shared Neighborhood Hits	47
SwissProt Accessions	P24610, Q3UFQ9, Q8BRE7, Q9CXI6	Gene names	Pax3, Pax-3
Domain Architecture
Description	Paired box protein Pax-3.

PAX3_HUMAN
NC score	-0.012425 (rank : 1406)	θ value	6.88961 (rank : 1216)
Query Neighborhood Hits	1275	Target Neighborhood Hits	513	Shared Neighborhood Hits	50
SwissProt Accessions	P23760, Q16448	Gene names	PAX3, HUP2
Domain Architecture
Description	Paired box protein Pax-3 (HUP2).

NKX28_MOUSE
NC score	-0.013111 (rank : 1407)	θ value	0.279714 (rank : 908)
Query Neighborhood Hits	1275	Target Neighborhood Hits	347	Shared Neighborhood Hits	16
SwissProt Accessions	O70584	Gene names	Nkx2-8, Nkx-2.9, Nkx2-9, Nkx2h
Domain Architecture
Description	Homeobox protein Nkx-2.8 (Homeobox protein NK-2 homolog H) (Homeobox protein Nkx-2.9).

PAX6_HUMAN
NC score	-0.013434 (rank : 1408)	θ value	6.88961 (rank : 1217)
Query Neighborhood Hits	1275	Target Neighborhood Hits	383	Shared Neighborhood Hits	19
SwissProt Accessions	P26367, Q6N006, Q99413	Gene names	PAX6, AN2
Domain Architecture
Description	Paired box protein Pax-6 (Oculorhombin) (Aniridia type II protein).

PAX6_MOUSE
NC score	-0.013434 (rank : 1409)	θ value	6.88961 (rank : 1218)
Query Neighborhood Hits	1275	Target Neighborhood Hits	383	Shared Neighborhood Hits	19
SwissProt Accessions	P63015, P32117, P70601, Q62222, Q64037, Q8CEI5, Q8VDB5, Q921Q8	Gene names	Pax6, Pax-6, Sey
Domain Architecture	No domain graphic available
Description	Paired box protein Pax-6 (Oculorhombin).

ZFHX2_HUMAN
NC score	-0.013780 (rank : 1410)	θ value	0.47712 (rank : 943)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1178	Shared Neighborhood Hits	105
SwissProt Accessions	Q9C0A1	Gene names	ZFHX2, KIAA1762
Domain Architecture
Description	Zinc finger homeobox protein 2.

ATBF1_HUMAN
NC score	-0.014804 (rank : 1411)	θ value	6.88961 (rank : 1191)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1547	Shared Neighborhood Hits	164
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ZEP2_HUMAN
NC score	-0.019020 (rank : 1412)	θ value	1.81305 (rank : 1056)
Query Neighborhood Hits	1275	Target Neighborhood Hits	937	Shared Neighborhood Hits	82
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

SALL1_HUMAN
NC score	-0.022707 (rank : 1413)	θ value	0.00390308 (rank : 826)
Query Neighborhood Hits	1275	Target Neighborhood Hits	821	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NSC2, Q99881, Q9NSC3, Q9P1R0	Gene names	SALL1, SAL1
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein SALL1) (Spalt-like transcription factor 1) (HSal1).

MTR1L_HUMAN
NC score	-0.022859 (rank : 1414)	θ value	0.62314 (rank : 959)
Query Neighborhood Hits	1275	Target Neighborhood Hits	1180	Shared Neighborhood Hits	72
SwissProt Accessions	Q13585	Gene names	GPR50
Domain Architecture
Description	Melatonin-related receptor (G protein-coupled receptor 50) (H9).

KLF17_HUMAN
NC score	-0.023242 (rank : 1415)	θ value	4.03905 (rank : 1120)
Query Neighborhood Hits	1275	Target Neighborhood Hits	882	Shared Neighborhood Hits	66
SwissProt Accessions	Q5JT82, Q86VQ7, Q8N805	Gene names	KLF17, ZNF393
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 17 (Zinc finger protein 393).

ACM4_MOUSE
NC score	-0.023551 (rank : 1416)	θ value	0.62314 (rank : 944)
Query Neighborhood Hits	1275	Target Neighborhood Hits	894	Shared Neighborhood Hits	13
SwissProt Accessions	P32211, Q64056	Gene names	Chrm4, Chrm-4
Domain Architecture
Description	Muscarinic acetylcholine receptor M4 (Mm4 mAChR).

ACM4_HUMAN
NC score	-0.023827 (rank : 1417)	θ value	0.47712 (rank : 928)
Query Neighborhood Hits	1275	Target Neighborhood Hits	889	Shared Neighborhood Hits	11
SwissProt Accessions	P08173	Gene names	CHRM4
Domain Architecture
Description	Muscarinic acetylcholine receptor M4.

ZN445_MOUSE
NC score	-0.025860 (rank : 1418)	θ value	3.0926 (rank : 1108)
Query Neighborhood Hits	1275	Target Neighborhood Hits	760	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R2V3, Q8K216	Gene names	Znf445, Zfp445
Domain Architecture
Description	Zinc finger protein 445.

KLF3_MOUSE
NC score	-0.025985 (rank : 1419)	θ value	5.27518 (rank : 1165)
Query Neighborhood Hits	1275	Target Neighborhood Hits	715	Shared Neighborhood Hits	19
SwissProt Accessions	Q60980	Gene names	Klf3, Bklf
Domain Architecture
Description	Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2).

ZN567_HUMAN
NC score	-0.026557 (rank : 1420)	θ value	5.27518 (rank : 1187)
Query Neighborhood Hits	1275	Target Neighborhood Hits	769	Shared Neighborhood Hits	17
SwissProt Accessions	Q8N184, Q6N044	Gene names	ZNF567
Domain Architecture	No domain graphic available
Description	Zinc finger protein 567.