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Network neighborhood for query Sequence : TLK2_HUMAN

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TLK2_HUMAN
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TLK1_HUMAN
θ value	0 (rank : 1)	NC score	0.991990 (rank : 3)
Query Neighborhood Hits	1044	Target Neighborhood Hits	967	Shared Neighborhood Hits	876
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	0 (rank : 2)	NC score	0.991578 (rank : 4)
Query Neighborhood Hits	1044	Target Neighborhood Hits	947	Shared Neighborhood Hits	863
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1044	Shared Neighborhood Hits	1044
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	0 (rank : 4)	NC score	0.996482 (rank : 2)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1088	Shared Neighborhood Hits	987
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

AURKC_MOUSE
θ value	1.73987e-27 (rank : 5)	NC score	0.938165 (rank : 5)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	783
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

PLK2_HUMAN
θ value	9.54697e-26 (rank : 6)	NC score	0.928746 (rank : 37)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	782
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	9.54697e-26 (rank : 7)	NC score	0.928549 (rank : 39)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	781
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

ULK3_MOUSE
θ value	8.08199e-25 (rank : 8)	NC score	0.937562 (rank : 6)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	785
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

KCC1A_MOUSE
θ value	4.01107e-24 (rank : 9)	NC score	0.929796 (rank : 30)
Query Neighborhood Hits	1044	Target Neighborhood Hits	845	Shared Neighborhood Hits	775
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_HUMAN
θ value	5.23862e-24 (rank : 10)	NC score	0.929574 (rank : 33)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	775
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

CHK2_MOUSE
θ value	6.84181e-24 (rank : 11)	NC score	0.933785 (rank : 13)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	775
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

KCC1G_HUMAN
θ value	1.5242e-23 (rank : 12)	NC score	0.929659 (rank : 32)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	774
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	1.5242e-23 (rank : 13)	NC score	0.929504 (rank : 34)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	774
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

TTK_HUMAN
θ value	1.99067e-23 (rank : 14)	NC score	0.911585 (rank : 156)
Query Neighborhood Hits	1044	Target Neighborhood Hits	816	Shared Neighborhood Hits	745
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

AURKC_HUMAN
θ value	2.59989e-23 (rank : 15)	NC score	0.935931 (rank : 8)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	784
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

STK36_HUMAN
θ value	2.59989e-23 (rank : 16)	NC score	0.931399 (rank : 23)
Query Neighborhood Hits	1044	Target Neighborhood Hits	896	Shared Neighborhood Hits	786
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

CHK2_HUMAN
θ value	3.39556e-23 (rank : 17)	NC score	0.932681 (rank : 19)
Query Neighborhood Hits	1044	Target Neighborhood Hits	859	Shared Neighborhood Hits	777
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

MARK4_HUMAN
θ value	5.79196e-23 (rank : 18)	NC score	0.926395 (rank : 56)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	783
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	5.79196e-23 (rank : 19)	NC score	0.926344 (rank : 57)
Query Neighborhood Hits	1044	Target Neighborhood Hits	898	Shared Neighborhood Hits	782
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

ST17A_HUMAN
θ value	7.56453e-23 (rank : 20)	NC score	0.930017 (rank : 29)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	769
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

KCC2G_HUMAN
θ value	9.87957e-23 (rank : 21)	NC score	0.924617 (rank : 72)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	770
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	9.87957e-23 (rank : 22)	NC score	0.924577 (rank : 75)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	770
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

PLK4_HUMAN
θ value	1.6852e-22 (rank : 23)	NC score	0.933117 (rank : 16)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	784
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

KCC2A_HUMAN
θ value	2.20094e-22 (rank : 24)	NC score	0.924775 (rank : 69)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	769
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2D_HUMAN
θ value	2.20094e-22 (rank : 25)	NC score	0.922831 (rank : 95)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	771
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

PIM2_MOUSE
θ value	2.20094e-22 (rank : 26)	NC score	0.916124 (rank : 138)
Query Neighborhood Hits	1044	Target Neighborhood Hits	809	Shared Neighborhood Hits	751
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

AKT1_HUMAN
θ value	2.87452e-22 (rank : 27)	NC score	0.898799 (rank : 262)
Query Neighborhood Hits	1044	Target Neighborhood Hits	885	Shared Neighborhood Hits	784
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

DAPK2_MOUSE
θ value	2.87452e-22 (rank : 28)	NC score	0.930708 (rank : 26)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	770
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

STK6_MOUSE
θ value	2.87452e-22 (rank : 29)	NC score	0.933487 (rank : 14)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	785
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

AKT2_HUMAN
θ value	3.75424e-22 (rank : 30)	NC score	0.900440 (rank : 249)
Query Neighborhood Hits	1044	Target Neighborhood Hits	878	Shared Neighborhood Hits	781
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

KCC2A_MOUSE
θ value	3.75424e-22 (rank : 31)	NC score	0.923623 (rank : 87)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	767
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

NUAK2_HUMAN
θ value	3.75424e-22 (rank : 32)	NC score	0.931635 (rank : 22)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	784
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

PLK4_MOUSE
θ value	6.40375e-22 (rank : 33)	NC score	0.933265 (rank : 15)
Query Neighborhood Hits	1044	Target Neighborhood Hits	879	Shared Neighborhood Hits	784
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

TTK_MOUSE
θ value	6.40375e-22 (rank : 34)	NC score	0.907326 (rank : 188)
Query Neighborhood Hits	1044	Target Neighborhood Hits	803	Shared Neighborhood Hits	728
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

ULK1_HUMAN
θ value	6.40375e-22 (rank : 35)	NC score	0.931364 (rank : 25)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1121	Shared Neighborhood Hits	787
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

AKT1_MOUSE
θ value	8.36355e-22 (rank : 36)	NC score	0.898837 (rank : 261)
Query Neighborhood Hits	1044	Target Neighborhood Hits	878	Shared Neighborhood Hits	784
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT3_HUMAN
θ value	8.36355e-22 (rank : 37)	NC score	0.902971 (rank : 229)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	782
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	8.36355e-22 (rank : 38)	NC score	0.902951 (rank : 230)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	782
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

MK06_HUMAN
θ value	8.36355e-22 (rank : 39)	NC score	0.882409 (rank : 368)
Query Neighborhood Hits	1044	Target Neighborhood Hits	815	Shared Neighborhood Hits	749
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

NUAK1_HUMAN
θ value	8.36355e-22 (rank : 40)	NC score	0.934168 (rank : 9)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	783
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

STK6_HUMAN
θ value	8.36355e-22 (rank : 41)	NC score	0.932615 (rank : 20)
Query Neighborhood Hits	1044	Target Neighborhood Hits	916	Shared Neighborhood Hits	789
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

AURKB_MOUSE
θ value	1.09232e-21 (rank : 42)	NC score	0.933030 (rank : 17)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	785
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

SGK3_MOUSE
θ value	1.09232e-21 (rank : 43)	NC score	0.900957 (rank : 243)
Query Neighborhood Hits	1044	Target Neighborhood Hits	882	Shared Neighborhood Hits	778
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

AKT2_MOUSE
θ value	1.42661e-21 (rank : 44)	NC score	0.899688 (rank : 253)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	778
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

NUAK1_MOUSE
θ value	1.42661e-21 (rank : 45)	NC score	0.933994 (rank : 12)
Query Neighborhood Hits	1044	Target Neighborhood Hits	881	Shared Neighborhood Hits	787
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

SGK3_HUMAN
θ value	1.42661e-21 (rank : 46)	NC score	0.900824 (rank : 244)
Query Neighborhood Hits	1044	Target Neighborhood Hits	877	Shared Neighborhood Hits	778
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

MK06_MOUSE
θ value	1.86321e-21 (rank : 47)	NC score	0.881867 (rank : 372)
Query Neighborhood Hits	1044	Target Neighborhood Hits	818	Shared Neighborhood Hits	749
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MARK3_MOUSE
θ value	2.43343e-21 (rank : 48)	NC score	0.923981 (rank : 85)
Query Neighborhood Hits	1044	Target Neighborhood Hits	919	Shared Neighborhood Hits	783
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

DAPK2_HUMAN
θ value	3.17815e-21 (rank : 49)	NC score	0.927540 (rank : 45)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	766
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MARK1_MOUSE
θ value	3.17815e-21 (rank : 50)	NC score	0.924082 (rank : 83)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	783
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	5.42112e-21 (rank : 51)	NC score	0.922570 (rank : 99)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1056	Shared Neighborhood Hits	791
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

ULK1_MOUSE
θ value	5.42112e-21 (rank : 52)	NC score	0.928424 (rank : 40)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1214	Shared Neighborhood Hits	791
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

MARK1_HUMAN
θ value	7.0802e-21 (rank : 53)	NC score	0.923435 (rank : 89)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	781
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

STK36_MOUSE
θ value	7.0802e-21 (rank : 54)	NC score	0.930045 (rank : 28)
Query Neighborhood Hits	1044	Target Neighborhood Hits	877	Shared Neighborhood Hits	785
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

PIM2_HUMAN
θ value	9.24701e-21 (rank : 55)	NC score	0.914793 (rank : 146)
Query Neighborhood Hits	1044	Target Neighborhood Hits	808	Shared Neighborhood Hits	757
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

KCC2B_HUMAN
θ value	1.2077e-20 (rank : 56)	NC score	0.921917 (rank : 107)
Query Neighborhood Hits	1044	Target Neighborhood Hits	866	Shared Neighborhood Hits	768
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	1.2077e-20 (rank : 57)	NC score	0.920486 (rank : 120)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	767
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

PDPK1_HUMAN
θ value	1.2077e-20 (rank : 58)	NC score	0.922417 (rank : 102)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	779
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	1.2077e-20 (rank : 59)	NC score	0.922416 (rank : 103)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	778
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

ULK2_MOUSE
θ value	1.5773e-20 (rank : 60)	NC score	0.934132 (rank : 10)
Query Neighborhood Hits	1044	Target Neighborhood Hits	943	Shared Neighborhood Hits	787
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

AURKB_HUMAN
θ value	2.06002e-20 (rank : 61)	NC score	0.934073 (rank : 11)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	784
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

DAPK1_HUMAN
θ value	2.06002e-20 (rank : 62)	NC score	0.841203 (rank : 508)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1130	Shared Neighborhood Hits	776
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DCAK1_MOUSE
θ value	2.69047e-20 (rank : 63)	NC score	0.917771 (rank : 133)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	776
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

ULK2_HUMAN
θ value	2.69047e-20 (rank : 64)	NC score	0.932891 (rank : 18)
Query Neighborhood Hits	1044	Target Neighborhood Hits	979	Shared Neighborhood Hits	785
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

TSSK3_HUMAN
θ value	3.51386e-20 (rank : 65)	NC score	0.921071 (rank : 116)
Query Neighborhood Hits	1044	Target Neighborhood Hits	806	Shared Neighborhood Hits	756
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

HUNK_MOUSE
θ value	4.58923e-20 (rank : 66)	NC score	0.926746 (rank : 55)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	781
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

K0999_MOUSE
θ value	4.58923e-20 (rank : 67)	NC score	0.922748 (rank : 96)
Query Neighborhood Hits	1044	Target Neighborhood Hits	931	Shared Neighborhood Hits	781
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MARK2_MOUSE
θ value	4.58923e-20 (rank : 68)	NC score	0.921876 (rank : 108)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1018	Shared Neighborhood Hits	782
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

ST32B_HUMAN
θ value	4.58923e-20 (rank : 69)	NC score	0.911353 (rank : 157)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	774
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

HUNK_HUMAN
θ value	5.99374e-20 (rank : 70)	NC score	0.926863 (rank : 52)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	781
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

K0999_HUMAN
θ value	5.99374e-20 (rank : 71)	NC score	0.923150 (rank : 91)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	781
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

NUAK2_MOUSE
θ value	5.99374e-20 (rank : 72)	NC score	0.929396 (rank : 36)
Query Neighborhood Hits	1044	Target Neighborhood Hits	878	Shared Neighborhood Hits	781
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

DAPK1_MOUSE
θ value	7.82807e-20 (rank : 73)	NC score	0.837226 (rank : 516)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1138	Shared Neighborhood Hits	776
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

SGK1_HUMAN
θ value	7.82807e-20 (rank : 74)	NC score	0.907370 (rank : 187)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	780
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SNRK_HUMAN
θ value	7.82807e-20 (rank : 75)	NC score	0.931372 (rank : 24)
Query Neighborhood Hits	1044	Target Neighborhood Hits	855	Shared Neighborhood Hits	769
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_MOUSE
θ value	7.82807e-20 (rank : 76)	NC score	0.931780 (rank : 21)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	765
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

ST32B_MOUSE
θ value	7.82807e-20 (rank : 77)	NC score	0.912245 (rank : 149)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	773
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

WNK3_HUMAN
θ value	7.82807e-20 (rank : 78)	NC score	0.892403 (rank : 303)
Query Neighborhood Hits	1044	Target Neighborhood Hits	948	Shared Neighborhood Hits	745
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

DAPK3_MOUSE
θ value	1.02238e-19 (rank : 79)	NC score	0.928327 (rank : 41)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	771
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KPCD1_HUMAN
θ value	1.02238e-19 (rank : 80)	NC score	0.922507 (rank : 101)
Query Neighborhood Hits	1044	Target Neighborhood Hits	901	Shared Neighborhood Hits	774
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

SGK1_MOUSE
θ value	1.33526e-19 (rank : 81)	NC score	0.906865 (rank : 193)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	781
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

DCAK1_HUMAN
θ value	1.74391e-19 (rank : 82)	NC score	0.917630 (rank : 135)
Query Neighborhood Hits	1044	Target Neighborhood Hits	877	Shared Neighborhood Hits	777
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KCC1D_HUMAN
θ value	1.74391e-19 (rank : 83)	NC score	0.926112 (rank : 58)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	774
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	1.74391e-19 (rank : 84)	NC score	0.926077 (rank : 59)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	774
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

WNK1_HUMAN
θ value	1.74391e-19 (rank : 85)	NC score	0.882893 (rank : 361)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1158	Shared Neighborhood Hits	752
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	1.74391e-19 (rank : 86)	NC score	0.881150 (rank : 380)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1179	Shared Neighborhood Hits	748
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

NEK11_HUMAN
θ value	2.27762e-19 (rank : 87)	NC score	0.919704 (rank : 127)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1043	Shared Neighborhood Hits	848
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TSSK2_HUMAN
θ value	2.27762e-19 (rank : 88)	NC score	0.924616 (rank : 73)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	766
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

CDK7_HUMAN
θ value	2.97466e-19 (rank : 89)	NC score	0.906694 (rank : 197)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	774
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK7_MOUSE
θ value	2.97466e-19 (rank : 90)	NC score	0.906811 (rank : 195)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	774
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

TSSK3_MOUSE
θ value	2.97466e-19 (rank : 91)	NC score	0.920041 (rank : 123)
Query Neighborhood Hits	1044	Target Neighborhood Hits	806	Shared Neighborhood Hits	757
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

ULK3_HUMAN
θ value	2.97466e-19 (rank : 92)	NC score	0.936391 (rank : 7)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	775
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

BRSK1_HUMAN
θ value	3.88503e-19 (rank : 93)	NC score	0.928214 (rank : 42)
Query Neighborhood Hits	1044	Target Neighborhood Hits	942	Shared Neighborhood Hits	776
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

PHKG1_HUMAN
θ value	3.88503e-19 (rank : 94)	NC score	0.924296 (rank : 81)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	774
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PIM1_MOUSE
θ value	3.88503e-19 (rank : 95)	NC score	0.910839 (rank : 162)
Query Neighborhood Hits	1044	Target Neighborhood Hits	787	Shared Neighborhood Hits	735
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

IKKB_MOUSE
θ value	5.07402e-19 (rank : 96)	NC score	0.921457 (rank : 111)
Query Neighborhood Hits	1044	Target Neighborhood Hits	984	Shared Neighborhood Hits	836
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KPCD1_MOUSE
θ value	5.07402e-19 (rank : 97)	NC score	0.922263 (rank : 105)
Query Neighborhood Hits	1044	Target Neighborhood Hits	891	Shared Neighborhood Hits	775
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PLK3_HUMAN
θ value	5.07402e-19 (rank : 98)	NC score	0.925480 (rank : 63)
Query Neighborhood Hits	1044	Target Neighborhood Hits	865	Shared Neighborhood Hits	781
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

ST32A_HUMAN
θ value	5.07402e-19 (rank : 99)	NC score	0.915041 (rank : 145)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	776
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

DCAK2_HUMAN
θ value	6.62687e-19 (rank : 100)	NC score	0.915064 (rank : 144)
Query Neighborhood Hits	1044	Target Neighborhood Hits	862	Shared Neighborhood Hits	773
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KPCD3_HUMAN
θ value	6.62687e-19 (rank : 101)	NC score	0.919550 (rank : 128)
Query Neighborhood Hits	1044	Target Neighborhood Hits	895	Shared Neighborhood Hits	770
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

SGK2_MOUSE
θ value	6.62687e-19 (rank : 102)	NC score	0.904053 (rank : 215)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	775
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ST32C_HUMAN
θ value	6.62687e-19 (rank : 103)	NC score	0.909902 (rank : 174)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	772
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	6.62687e-19 (rank : 104)	NC score	0.911910 (rank : 153)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	772
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

CAMKV_HUMAN
θ value	8.65492e-19 (rank : 105)	NC score	0.893114 (rank : 294)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1084	Shared Neighborhood Hits	726
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	8.65492e-19 (rank : 106)	NC score	0.899891 (rank : 250)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	723
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CD2L5_HUMAN
θ value	8.65492e-19 (rank : 107)	NC score	0.894292 (rank : 289)
Query Neighborhood Hits	1044	Target Neighborhood Hits	987	Shared Neighborhood Hits	778
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	8.65492e-19 (rank : 108)	NC score	0.893917 (rank : 291)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1011	Shared Neighborhood Hits	775
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L7_HUMAN
θ value	8.65492e-19 (rank : 109)	NC score	0.892283 (rank : 305)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1275	Shared Neighborhood Hits	797
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

KCC4_MOUSE
θ value	8.65492e-19 (rank : 110)	NC score	0.928714 (rank : 38)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	783
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KKCC2_HUMAN
θ value	8.65492e-19 (rank : 111)	NC score	0.924732 (rank : 70)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	779
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	8.65492e-19 (rank : 112)	NC score	0.924717 (rank : 71)
Query Neighborhood Hits	1044	Target Neighborhood Hits	855	Shared Neighborhood Hits	779
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCD3_MOUSE
θ value	8.65492e-19 (rank : 113)	NC score	0.919833 (rank : 125)
Query Neighborhood Hits	1044	Target Neighborhood Hits	901	Shared Neighborhood Hits	771
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

NEK1_MOUSE
θ value	8.65492e-19 (rank : 114)	NC score	0.917767 (rank : 134)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1311	Shared Neighborhood Hits	868
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK4_MOUSE
θ value	8.65492e-19 (rank : 115)	NC score	0.920095 (rank : 122)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	784
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

TSSK1_MOUSE
θ value	8.65492e-19 (rank : 116)	NC score	0.926821 (rank : 53)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	770
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

CDKL4_MOUSE
θ value	1.13037e-18 (rank : 117)	NC score	0.910613 (rank : 164)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	774
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

IKKA_MOUSE
θ value	1.13037e-18 (rank : 118)	NC score	0.918076 (rank : 131)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	787
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	1.13037e-18 (rank : 119)	NC score	0.921328 (rank : 112)
Query Neighborhood Hits	1044	Target Neighborhood Hits	980	Shared Neighborhood Hits	836
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KCC1B_MOUSE
θ value	1.13037e-18 (rank : 120)	NC score	0.927455 (rank : 46)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	779
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

SN1L2_MOUSE
θ value	1.13037e-18 (rank : 121)	NC score	0.922661 (rank : 98)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	787
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

AAPK2_HUMAN
θ value	1.47631e-18 (rank : 122)	NC score	0.925076 (rank : 68)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	778
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

DAPK3_HUMAN
θ value	1.47631e-18 (rank : 123)	NC score	0.929691 (rank : 31)
Query Neighborhood Hits	1044	Target Neighborhood Hits	945	Shared Neighborhood Hits	807
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KCC1B_HUMAN
θ value	1.47631e-18 (rank : 124)	NC score	0.927151 (rank : 50)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	779
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC4_HUMAN
θ value	1.47631e-18 (rank : 125)	NC score	0.928033 (rank : 44)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	773
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

MK04_HUMAN
θ value	1.47631e-18 (rank : 126)	NC score	0.888679 (rank : 320)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	767
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

PLK3_MOUSE
θ value	1.47631e-18 (rank : 127)	NC score	0.925438 (rank : 64)
Query Neighborhood Hits	1044	Target Neighborhood Hits	863	Shared Neighborhood Hits	780
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

ST32A_MOUSE
θ value	1.47631e-18 (rank : 128)	NC score	0.915573 (rank : 143)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	777
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

CHK1_HUMAN
θ value	2.5182e-18 (rank : 129)	NC score	0.930392 (rank : 27)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	777
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

PLK1_HUMAN
θ value	2.5182e-18 (rank : 130)	NC score	0.922412 (rank : 104)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	775
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

DCAK2_MOUSE
θ value	3.28887e-18 (rank : 131)	NC score	0.915844 (rank : 141)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	774
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

NEK6_HUMAN
θ value	3.28887e-18 (rank : 132)	NC score	0.921309 (rank : 113)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	784
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

SN1L2_HUMAN
θ value	3.28887e-18 (rank : 133)	NC score	0.922693 (rank : 97)
Query Neighborhood Hits	1044	Target Neighborhood Hits	964	Shared Neighborhood Hits	790
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

KPCD2_HUMAN
θ value	4.29542e-18 (rank : 134)	NC score	0.922872 (rank : 94)
Query Neighborhood Hits	1044	Target Neighborhood Hits	910	Shared Neighborhood Hits	775
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

NEK6_MOUSE
θ value	5.60996e-18 (rank : 135)	NC score	0.921269 (rank : 114)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	784
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

PCTK2_HUMAN
θ value	5.60996e-18 (rank : 136)	NC score	0.896362 (rank : 276)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	772
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_MOUSE
θ value	5.60996e-18 (rank : 137)	NC score	0.896115 (rank : 279)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	772
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PLK1_MOUSE
θ value	5.60996e-18 (rank : 138)	NC score	0.923586 (rank : 88)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	776
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KKCC1_MOUSE
θ value	7.32683e-18 (rank : 139)	NC score	0.924321 (rank : 80)
Query Neighborhood Hits	1044	Target Neighborhood Hits	866	Shared Neighborhood Hits	780
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PIM1_HUMAN
θ value	7.32683e-18 (rank : 140)	NC score	0.912180 (rank : 150)
Query Neighborhood Hits	1044	Target Neighborhood Hits	797	Shared Neighborhood Hits	744
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

SLK_MOUSE
θ value	7.32683e-18 (rank : 141)	NC score	0.886902 (rank : 326)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1798	Shared Neighborhood Hits	953
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

MARK3_HUMAN
θ value	9.56915e-18 (rank : 142)	NC score	0.916732 (rank : 137)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	778
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

NEK11_MOUSE
θ value	1.24977e-17 (rank : 143)	NC score	0.919969 (rank : 124)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	789
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

PFTK1_MOUSE
θ value	1.24977e-17 (rank : 144)	NC score	0.901473 (rank : 237)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	769
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

MK04_MOUSE
θ value	1.63225e-17 (rank : 145)	NC score	0.886651 (rank : 330)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	763
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

SLK_HUMAN
θ value	1.63225e-17 (rank : 146)	NC score	0.885682 (rank : 341)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1775	Shared Neighborhood Hits	956
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

KKCC1_HUMAN
θ value	2.13179e-17 (rank : 147)	NC score	0.923894 (rank : 86)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	779
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KS6B1_HUMAN
θ value	2.13179e-17 (rank : 148)	NC score	0.904536 (rank : 213)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	779
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	2.13179e-17 (rank : 149)	NC score	0.904556 (rank : 212)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	779
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

MAPK2_HUMAN
θ value	2.13179e-17 (rank : 150)	NC score	0.910488 (rank : 165)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	766
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MK12_MOUSE
θ value	2.13179e-17 (rank : 151)	NC score	0.897413 (rank : 268)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	774
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

IKKA_HUMAN
θ value	2.7842e-17 (rank : 152)	NC score	0.916005 (rank : 139)
Query Neighborhood Hits	1044	Target Neighborhood Hits	863	Shared Neighborhood Hits	782
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KPSH2_HUMAN
θ value	2.7842e-17 (rank : 153)	NC score	0.924470 (rank : 76)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	766
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

MAPK2_MOUSE
θ value	2.7842e-17 (rank : 154)	NC score	0.909683 (rank : 176)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	764
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MYLK_HUMAN
θ value	2.7842e-17 (rank : 155)	NC score	0.847642 (rank : 493)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1328	Shared Neighborhood Hits	779
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

WNK2_HUMAN
θ value	2.7842e-17 (rank : 156)	NC score	0.872237 (rank : 423)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1407	Shared Neighborhood Hits	742
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

SN1L1_HUMAN
θ value	3.63628e-17 (rank : 157)	NC score	0.925307 (rank : 65)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	782
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

PCTK3_HUMAN
θ value	4.74913e-17 (rank : 158)	NC score	0.897424 (rank : 267)
Query Neighborhood Hits	1044	Target Neighborhood Hits	827	Shared Neighborhood Hits	768
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

MK14_MOUSE
θ value	6.20254e-17 (rank : 159)	NC score	0.894334 (rank : 288)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	776
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

NEK3_MOUSE
θ value	6.20254e-17 (rank : 160)	NC score	0.922874 (rank : 93)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	782
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	6.20254e-17 (rank : 161)	NC score	0.917939 (rank : 132)
Query Neighborhood Hits	1044	Target Neighborhood Hits	883	Shared Neighborhood Hits	781
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NIM1_HUMAN
θ value	6.20254e-17 (rank : 162)	NC score	0.927207 (rank : 49)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	779
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PFTK1_HUMAN
θ value	6.20254e-17 (rank : 163)	NC score	0.900757 (rank : 247)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	767
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

SGK2_HUMAN
θ value	6.20254e-17 (rank : 164)	NC score	0.903680 (rank : 218)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	777
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ST17B_HUMAN
θ value	6.20254e-17 (rank : 165)	NC score	0.924249 (rank : 82)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	770
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

TSSK2_MOUSE
θ value	6.20254e-17 (rank : 166)	NC score	0.918647 (rank : 129)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	762
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

AL2S7_HUMAN
θ value	8.10077e-17 (rank : 167)	NC score	0.894905 (rank : 284)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	767
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

MYLK_MOUSE
θ value	8.10077e-17 (rank : 168)	NC score	0.844418 (rank : 500)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1489	Shared Neighborhood Hits	782
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

STK4_HUMAN
θ value	8.10077e-17 (rank : 169)	NC score	0.901521 (rank : 236)
Query Neighborhood Hits	1044	Target Neighborhood Hits	870	Shared Neighborhood Hits	785
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	8.10077e-17 (rank : 170)	NC score	0.901470 (rank : 238)
Query Neighborhood Hits	1044	Target Neighborhood Hits	873	Shared Neighborhood Hits	785
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

AAPK1_HUMAN
θ value	1.058e-16 (rank : 171)	NC score	0.925984 (rank : 61)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	779
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	1.058e-16 (rank : 172)	NC score	0.926020 (rank : 60)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	779
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

ANKK1_MOUSE
θ value	1.058e-16 (rank : 173)	NC score	0.669143 (rank : 755)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1072	Shared Neighborhood Hits	743
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

KPSH1_HUMAN
θ value	1.058e-16 (rank : 174)	NC score	0.924606 (rank : 74)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	774
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

MK14_HUMAN
θ value	1.058e-16 (rank : 175)	NC score	0.894201 (rank : 290)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	776
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MKNK1_MOUSE
θ value	1.058e-16 (rank : 176)	NC score	0.903592 (rank : 223)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	754
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

NEK7_HUMAN
θ value	1.058e-16 (rank : 177)	NC score	0.915689 (rank : 142)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	782
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

PCTK3_MOUSE
θ value	1.058e-16 (rank : 178)	NC score	0.899066 (rank : 257)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	771
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

ZAP70_HUMAN
θ value	1.058e-16 (rank : 179)	NC score	0.771661 (rank : 585)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	763
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

KPSH1_MOUSE
θ value	1.80466e-16 (rank : 180)	NC score	0.924421 (rank : 78)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	774
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

SN1L1_MOUSE
θ value	1.80466e-16 (rank : 181)	NC score	0.925306 (rank : 66)
Query Neighborhood Hits	1044	Target Neighborhood Hits	895	Shared Neighborhood Hits	782
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

KS6B2_HUMAN
θ value	2.35696e-16 (rank : 182)	NC score	0.902166 (rank : 233)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	777
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

WNK4_HUMAN
θ value	2.35696e-16 (rank : 183)	NC score	0.874625 (rank : 411)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1043	Shared Neighborhood Hits	723
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

BRSK2_HUMAN
θ value	3.07829e-16 (rank : 184)	NC score	0.927248 (rank : 48)
Query Neighborhood Hits	1044	Target Neighborhood Hits	897	Shared Neighborhood Hits	783
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

CDKL4_HUMAN
θ value	3.07829e-16 (rank : 185)	NC score	0.906243 (rank : 200)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	771
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

MELK_HUMAN
θ value	3.07829e-16 (rank : 186)	NC score	0.920142 (rank : 121)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	776
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MK12_HUMAN
θ value	3.07829e-16 (rank : 187)	NC score	0.896514 (rank : 274)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	773
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PAK2_HUMAN
θ value	3.07829e-16 (rank : 188)	NC score	0.910034 (rank : 173)
Query Neighborhood Hits	1044	Target Neighborhood Hits	862	Shared Neighborhood Hits	786
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	3.07829e-16 (rank : 189)	NC score	0.910047 (rank : 172)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	784
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PHKG1_MOUSE
θ value	3.07829e-16 (rank : 190)	NC score	0.924389 (rank : 79)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	774
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

TNI3K_MOUSE
θ value	3.07829e-16 (rank : 191)	NC score	0.729137 (rank : 639)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1079	Shared Neighborhood Hits	740
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

NEK3_HUMAN
θ value	4.02038e-16 (rank : 192)	NC score	0.922558 (rank : 100)
Query Neighborhood Hits	1044	Target Neighborhood Hits	865	Shared Neighborhood Hits	787
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK7_MOUSE
θ value	4.02038e-16 (rank : 193)	NC score	0.915890 (rank : 140)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	784
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NIM1_MOUSE
θ value	4.02038e-16 (rank : 194)	NC score	0.927436 (rank : 47)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	780
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

TNI3K_HUMAN
θ value	4.02038e-16 (rank : 195)	NC score	0.723645 (rank : 654)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1084	Shared Neighborhood Hits	745
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CHK1_MOUSE
θ value	5.25075e-16 (rank : 196)	NC score	0.929432 (rank : 35)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	777
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MAST1_HUMAN
θ value	5.25075e-16 (rank : 197)	NC score	0.886089 (rank : 339)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1146	Shared Neighborhood Hits	788
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST3_HUMAN
θ value	5.25075e-16 (rank : 198)	NC score	0.891492 (rank : 312)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1128	Shared Neighborhood Hits	786
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MK15_MOUSE
θ value	5.25075e-16 (rank : 199)	NC score	0.896128 (rank : 278)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	767
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

ZAP70_MOUSE
θ value	5.25075e-16 (rank : 200)	NC score	0.769130 (rank : 590)
Query Neighborhood Hits	1044	Target Neighborhood Hits	905	Shared Neighborhood Hits	770
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ANKK1_HUMAN
θ value	6.85773e-16 (rank : 201)	NC score	0.656687 (rank : 767)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1075	Shared Neighborhood Hits	739
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

KGP2_HUMAN
θ value	6.85773e-16 (rank : 202)	NC score	0.895509 (rank : 282)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1023	Shared Neighborhood Hits	843
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KS6A5_HUMAN
θ value	8.95645e-16 (rank : 203)	NC score	0.905124 (rank : 211)
Query Neighborhood Hits	1044	Target Neighborhood Hits	855	Shared Neighborhood Hits	782
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

ST17B_MOUSE
θ value	8.95645e-16 (rank : 204)	NC score	0.925141 (rank : 67)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	771
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

WNK4_MOUSE
θ value	1.16975e-15 (rank : 205)	NC score	0.877049 (rank : 400)
Query Neighborhood Hits	1044	Target Neighborhood Hits	961	Shared Neighborhood Hits	730
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

M3K3_MOUSE
θ value	1.52774e-15 (rank : 206)	NC score	0.910397 (rank : 166)
Query Neighborhood Hits	1044	Target Neighborhood Hits	876	Shared Neighborhood Hits	778
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K9_HUMAN
θ value	1.52774e-15 (rank : 207)	NC score	0.840109 (rank : 510)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1123	Shared Neighborhood Hits	805
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MAST4_HUMAN
θ value	1.52774e-15 (rank : 208)	NC score	0.874486 (rank : 412)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1804	Shared Neighborhood Hits	812
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

PHKG2_HUMAN
θ value	1.52774e-15 (rank : 209)	NC score	0.923128 (rank : 92)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	773
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

STK3_MOUSE
θ value	1.52774e-15 (rank : 210)	NC score	0.901070 (rank : 241)
Query Neighborhood Hits	1044	Target Neighborhood Hits	869	Shared Neighborhood Hits	783
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

M3K3_HUMAN
θ value	1.99529e-15 (rank : 211)	NC score	0.910157 (rank : 171)
Query Neighborhood Hits	1044	Target Neighborhood Hits	885	Shared Neighborhood Hits	779
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K5_HUMAN
θ value	1.99529e-15 (rank : 212)	NC score	0.910250 (rank : 168)
Query Neighborhood Hits	1044	Target Neighborhood Hits	868	Shared Neighborhood Hits	783
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	1.99529e-15 (rank : 213)	NC score	0.910334 (rank : 167)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	782
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

ST38L_HUMAN
θ value	1.99529e-15 (rank : 214)	NC score	0.877449 (rank : 396)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	759
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

TSSK4_MOUSE
θ value	1.99529e-15 (rank : 215)	NC score	0.924428 (rank : 77)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	780
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

CSKP_HUMAN
θ value	2.60593e-15 (rank : 216)	NC score	0.866863 (rank : 442)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1022	Shared Neighborhood Hits	769
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	2.60593e-15 (rank : 217)	NC score	0.869378 (rank : 435)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1027	Shared Neighborhood Hits	769
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DCAK3_HUMAN
θ value	2.60593e-15 (rank : 218)	NC score	0.927020 (rank : 51)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	781
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

KGP2_MOUSE
θ value	2.60593e-15 (rank : 219)	NC score	0.893849 (rank : 292)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1029	Shared Neighborhood Hits	840
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KS6A1_HUMAN
θ value	2.60593e-15 (rank : 220)	NC score	0.905411 (rank : 207)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	783
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

M3K10_HUMAN
θ value	2.60593e-15 (rank : 221)	NC score	0.839924 (rank : 511)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1071	Shared Neighborhood Hits	800
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MAST1_MOUSE
θ value	2.60593e-15 (rank : 222)	NC score	0.886214 (rank : 337)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1123	Shared Neighborhood Hits	787
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

STK3_HUMAN
θ value	2.60593e-15 (rank : 223)	NC score	0.900823 (rank : 245)
Query Neighborhood Hits	1044	Target Neighborhood Hits	861	Shared Neighborhood Hits	785
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

CDK5_HUMAN
θ value	3.40345e-15 (rank : 224)	NC score	0.893139 (rank : 293)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	767
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	3.40345e-15 (rank : 225)	NC score	0.892995 (rank : 297)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	767
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

IKKE_HUMAN
θ value	3.40345e-15 (rank : 226)	NC score	0.913463 (rank : 147)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	773
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KSYK_MOUSE
θ value	3.40345e-15 (rank : 227)	NC score	0.772390 (rank : 583)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	762
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MK15_HUMAN
θ value	3.40345e-15 (rank : 228)	NC score	0.897036 (rank : 270)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1038	Shared Neighborhood Hits	769
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

TSSK1_HUMAN
θ value	3.40345e-15 (rank : 229)	NC score	0.920658 (rank : 119)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	761
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

CDC2_HUMAN
θ value	4.44505e-15 (rank : 230)	NC score	0.903675 (rank : 219)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	780
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

KPCI_HUMAN
θ value	4.44505e-15 (rank : 231)	NC score	0.886756 (rank : 327)
Query Neighborhood Hits	1044	Target Neighborhood Hits	885	Shared Neighborhood Hits	777
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	4.44505e-15 (rank : 232)	NC score	0.886546 (rank : 331)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	777
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KSYK_HUMAN
θ value	4.44505e-15 (rank : 233)	NC score	0.772786 (rank : 582)
Query Neighborhood Hits	1044	Target Neighborhood Hits	901	Shared Neighborhood Hits	761
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MAST2_HUMAN
θ value	4.44505e-15 (rank : 234)	NC score	0.888895 (rank : 319)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1189	Shared Neighborhood Hits	788
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

NEK1_HUMAN
θ value	4.44505e-15 (rank : 235)	NC score	0.918234 (rank : 130)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1129	Shared Neighborhood Hits	858
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

CDKL1_MOUSE
θ value	5.8054e-15 (rank : 236)	NC score	0.905582 (rank : 203)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	770
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

KAPCB_HUMAN
θ value	5.8054e-15 (rank : 237)	NC score	0.903597 (rank : 222)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	775
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KS6A6_HUMAN
θ value	5.8054e-15 (rank : 238)	NC score	0.906913 (rank : 192)
Query Neighborhood Hits	1044	Target Neighborhood Hits	853	Shared Neighborhood Hits	780
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

MAST2_MOUSE
θ value	5.8054e-15 (rank : 239)	NC score	0.890363 (rank : 316)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1110	Shared Neighborhood Hits	787
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MK01_HUMAN
θ value	5.8054e-15 (rank : 240)	NC score	0.884450 (rank : 348)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	773
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_HUMAN
θ value	5.8054e-15 (rank : 241)	NC score	0.888401 (rank : 321)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	777
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

PHKG2_MOUSE
θ value	5.8054e-15 (rank : 242)	NC score	0.923230 (rank : 90)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	772
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

TAOK3_HUMAN
θ value	5.8054e-15 (rank : 243)	NC score	0.870211 (rank : 432)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1494	Shared Neighborhood Hits	947
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TSSK4_HUMAN
θ value	5.8054e-15 (rank : 244)	NC score	0.920752 (rank : 118)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	776
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

CDC2_MOUSE
θ value	7.58209e-15 (rank : 245)	NC score	0.903830 (rank : 216)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	778
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK6_MOUSE
θ value	7.58209e-15 (rank : 246)	NC score	0.892815 (rank : 299)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	770
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

CDKL1_HUMAN
θ value	7.58209e-15 (rank : 247)	NC score	0.906719 (rank : 196)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	773
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

KAPCB_MOUSE
θ value	7.58209e-15 (rank : 248)	NC score	0.903124 (rank : 228)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	775
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KS6A4_MOUSE
θ value	7.58209e-15 (rank : 249)	NC score	0.900562 (rank : 248)
Query Neighborhood Hits	1044	Target Neighborhood Hits	866	Shared Neighborhood Hits	782
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

M3K2_HUMAN
θ value	7.58209e-15 (rank : 250)	NC score	0.911796 (rank : 154)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	779
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MK01_MOUSE
θ value	7.58209e-15 (rank : 251)	NC score	0.884611 (rank : 347)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	773
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK03_MOUSE
θ value	7.58209e-15 (rank : 252)	NC score	0.888114 (rank : 323)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	777
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

PAK1_HUMAN
θ value	7.58209e-15 (rank : 253)	NC score	0.907051 (rank : 190)
Query Neighborhood Hits	1044	Target Neighborhood Hits	873	Shared Neighborhood Hits	785
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PCTK1_HUMAN
θ value	7.58209e-15 (rank : 254)	NC score	0.897256 (rank : 269)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	770
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

TAOK3_MOUSE
θ value	7.58209e-15 (rank : 255)	NC score	0.871591 (rank : 428)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1458	Shared Neighborhood Hits	943
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

CDK6_HUMAN
θ value	9.90251e-15 (rank : 256)	NC score	0.891782 (rank : 311)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	770
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

IKKE_MOUSE
θ value	9.90251e-15 (rank : 257)	NC score	0.913012 (rank : 148)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	778
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KAPCG_HUMAN
θ value	9.90251e-15 (rank : 258)	NC score	0.907697 (rank : 184)
Query Neighborhood Hits	1044	Target Neighborhood Hits	845	Shared Neighborhood Hits	776
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KS6A3_HUMAN
θ value	9.90251e-15 (rank : 259)	NC score	0.905341 (rank : 209)
Query Neighborhood Hits	1044	Target Neighborhood Hits	859	Shared Neighborhood Hits	784
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	9.90251e-15 (rank : 260)	NC score	0.905357 (rank : 208)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	784
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A5_MOUSE
θ value	9.90251e-15 (rank : 261)	NC score	0.898698 (rank : 263)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	780
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

PCTK1_MOUSE
θ value	9.90251e-15 (rank : 262)	NC score	0.896988 (rank : 271)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	770
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PIM3_HUMAN
θ value	9.90251e-15 (rank : 263)	NC score	0.905714 (rank : 201)
Query Neighborhood Hits	1044	Target Neighborhood Hits	789	Shared Neighborhood Hits	746
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

KPCZ_HUMAN
θ value	1.29331e-14 (rank : 264)	NC score	0.881711 (rank : 375)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	770
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
θ value	1.29331e-14 (rank : 265)	NC score	0.881672 (rank : 376)
Query Neighborhood Hits	1044	Target Neighborhood Hits	882	Shared Neighborhood Hits	770
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

OBSCN_HUMAN
θ value	1.29331e-14 (rank : 266)	NC score	0.806735 (rank : 555)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1931	Shared Neighborhood Hits	804
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

ST38L_MOUSE
θ value	1.29331e-14 (rank : 267)	NC score	0.869440 (rank : 434)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	752
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

KS6B2_MOUSE
θ value	1.68911e-14 (rank : 268)	NC score	0.899757 (rank : 252)
Query Neighborhood Hits	1044	Target Neighborhood Hits	871	Shared Neighborhood Hits	776
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

M3K2_MOUSE
θ value	1.68911e-14 (rank : 269)	NC score	0.911180 (rank : 159)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	775
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MYLK2_HUMAN
θ value	1.68911e-14 (rank : 270)	NC score	0.925696 (rank : 62)
Query Neighborhood Hits	1044	Target Neighborhood Hits	920	Shared Neighborhood Hits	764
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

PAK3_HUMAN
θ value	1.68911e-14 (rank : 271)	NC score	0.906825 (rank : 194)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	787
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	1.68911e-14 (rank : 272)	NC score	0.907055 (rank : 189)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	786
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

CD2L6_HUMAN
θ value	2.20605e-14 (rank : 273)	NC score	0.877189 (rank : 397)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	766
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	2.20605e-14 (rank : 274)	NC score	0.877133 (rank : 398)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	767
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

EPHA3_MOUSE
θ value	2.20605e-14 (rank : 275)	NC score	0.720695 (rank : 666)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	765
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

ICK_HUMAN
θ value	2.20605e-14 (rank : 276)	NC score	0.898871 (rank : 260)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	776
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

MAPK5_HUMAN
θ value	2.20605e-14 (rank : 277)	NC score	0.894553 (rank : 286)
Query Neighborhood Hits	1044	Target Neighborhood Hits	795	Shared Neighborhood Hits	747
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MELK_MOUSE
θ value	2.20605e-14 (rank : 278)	NC score	0.919707 (rank : 126)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	775
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

STK38_MOUSE
θ value	2.20605e-14 (rank : 279)	NC score	0.876972 (rank : 401)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	770
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

DCAK3_MOUSE
θ value	2.88119e-14 (rank : 280)	NC score	0.926799 (rank : 54)
Query Neighborhood Hits	1044	Target Neighborhood Hits	922	Shared Neighborhood Hits	783
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

EPHA3_HUMAN
θ value	2.88119e-14 (rank : 281)	NC score	0.726682 (rank : 646)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1005	Shared Neighborhood Hits	761
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

MP2K5_MOUSE
θ value	2.88119e-14 (rank : 282)	NC score	0.898574 (rank : 264)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	781
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

TBK1_MOUSE
θ value	2.88119e-14 (rank : 283)	NC score	0.910839 (rank : 163)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	801
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

ICK_MOUSE
θ value	3.76295e-14 (rank : 284)	NC score	0.899490 (rank : 256)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	777
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MAPK5_MOUSE
θ value	3.76295e-14 (rank : 285)	NC score	0.894955 (rank : 283)
Query Neighborhood Hits	1044	Target Neighborhood Hits	799	Shared Neighborhood Hits	749
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

CCRK_HUMAN
θ value	4.91457e-14 (rank : 286)	NC score	0.892071 (rank : 308)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	776
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CDK8_HUMAN
θ value	4.91457e-14 (rank : 287)	NC score	0.875389 (rank : 404)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	766
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

EPHA1_MOUSE
θ value	4.91457e-14 (rank : 288)	NC score	0.704746 (rank : 698)
Query Neighborhood Hits	1044	Target Neighborhood Hits	958	Shared Neighborhood Hits	735
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

MP2K2_HUMAN
θ value	4.91457e-14 (rank : 289)	NC score	0.902103 (rank : 234)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	777
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PIM3_MOUSE
θ value	4.91457e-14 (rank : 290)	NC score	0.905144 (rank : 210)
Query Neighborhood Hits	1044	Target Neighborhood Hits	783	Shared Neighborhood Hits	740
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

STK38_HUMAN
θ value	4.91457e-14 (rank : 291)	NC score	0.876674 (rank : 402)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	770
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

TBK1_HUMAN
θ value	4.91457e-14 (rank : 292)	NC score	0.909836 (rank : 175)
Query Neighborhood Hits	1044	Target Neighborhood Hits	861	Shared Neighborhood Hits	781
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

EPHA8_HUMAN
θ value	6.41864e-14 (rank : 293)	NC score	0.710949 (rank : 686)
Query Neighborhood Hits	1044	Target Neighborhood Hits	956	Shared Neighborhood Hits	752
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

KS6A4_HUMAN
θ value	6.41864e-14 (rank : 294)	NC score	0.899556 (rank : 254)
Query Neighborhood Hits	1044	Target Neighborhood Hits	868	Shared Neighborhood Hits	782
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

LATS2_HUMAN
θ value	6.41864e-14 (rank : 295)	NC score	0.858534 (rank : 466)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	765
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

NEK8_HUMAN
θ value	6.41864e-14 (rank : 296)	NC score	0.908296 (rank : 180)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	782
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

STK33_HUMAN
θ value	6.41864e-14 (rank : 297)	NC score	0.928127 (rank : 43)
Query Neighborhood Hits	1044	Target Neighborhood Hits	879	Shared Neighborhood Hits	783
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

KAPCA_HUMAN
θ value	8.38298e-14 (rank : 298)	NC score	0.903208 (rank : 227)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	775
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	8.38298e-14 (rank : 299)	NC score	0.903229 (rank : 225)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	773
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KPCE_MOUSE
θ value	8.38298e-14 (rank : 300)	NC score	0.883145 (rank : 359)
Query Neighborhood Hits	1044	Target Neighborhood Hits	906	Shared Neighborhood Hits	768
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MP2K1_HUMAN
θ value	8.38298e-14 (rank : 301)	NC score	0.901587 (rank : 235)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	774
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MRCKB_MOUSE
θ value	8.38298e-14 (rank : 302)	NC score	0.808539 (rank : 553)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2180	Shared Neighborhood Hits	967
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TAOK2_HUMAN
θ value	8.38298e-14 (rank : 303)	NC score	0.883967 (rank : 350)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1172	Shared Neighborhood Hits	893
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	8.38298e-14 (rank : 304)	NC score	0.876129 (rank : 403)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1373	Shared Neighborhood Hits	927
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

ARBK2_HUMAN
θ value	1.09485e-13 (rank : 305)	NC score	0.882865 (rank : 362)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	773
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

LATS1_HUMAN
θ value	1.09485e-13 (rank : 306)	NC score	0.859795 (rank : 459)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1057	Shared Neighborhood Hits	791
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
θ value	1.09485e-13 (rank : 307)	NC score	0.857926 (rank : 469)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1027	Shared Neighborhood Hits	786
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

M3K15_HUMAN
θ value	1.09485e-13 (rank : 308)	NC score	0.908208 (rank : 181)
Query Neighborhood Hits	1044	Target Neighborhood Hits	914	Shared Neighborhood Hits	798
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

MK11_MOUSE
θ value	1.09485e-13 (rank : 309)	NC score	0.887178 (rank : 325)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	771
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

NEK8_MOUSE
θ value	1.09485e-13 (rank : 310)	NC score	0.908047 (rank : 182)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	782
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

KS6A2_HUMAN
θ value	1.42992e-13 (rank : 311)	NC score	0.906455 (rank : 198)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	785
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

MP2K1_MOUSE
θ value	1.42992e-13 (rank : 312)	NC score	0.901341 (rank : 239)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	774
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

NEK9_HUMAN
θ value	1.42992e-13 (rank : 313)	NC score	0.896545 (rank : 273)
Query Neighborhood Hits	1044	Target Neighborhood Hits	900	Shared Neighborhood Hits	784
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	1.42992e-13 (rank : 314)	NC score	0.896706 (rank : 272)
Query Neighborhood Hits	1044	Target Neighborhood Hits	890	Shared Neighborhood Hits	786
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

EPHA7_MOUSE
θ value	1.86753e-13 (rank : 315)	NC score	0.722963 (rank : 655)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1025	Shared Neighborhood Hits	761
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

MKNK2_MOUSE
θ value	1.86753e-13 (rank : 316)	NC score	0.903788 (rank : 217)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	766
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MOK_MOUSE
θ value	1.86753e-13 (rank : 317)	NC score	0.871721 (rank : 425)
Query Neighborhood Hits	1044	Target Neighborhood Hits	796	Shared Neighborhood Hits	748
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MRCKB_HUMAN
θ value	1.86753e-13 (rank : 318)	NC score	0.801221 (rank : 560)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2239	Shared Neighborhood Hits	965
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MYO3A_HUMAN
θ value	1.86753e-13 (rank : 319)	NC score	0.797584 (rank : 567)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1033	Shared Neighborhood Hits	834
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

NEK2_HUMAN
θ value	1.86753e-13 (rank : 320)	NC score	0.921106 (rank : 115)
Query Neighborhood Hits	1044	Target Neighborhood Hits	908	Shared Neighborhood Hits	795
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

PAK1_MOUSE
θ value	1.86753e-13 (rank : 321)	NC score	0.905688 (rank : 202)
Query Neighborhood Hits	1044	Target Neighborhood Hits	878	Shared Neighborhood Hits	784
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK6_HUMAN
θ value	1.86753e-13 (rank : 322)	NC score	0.908525 (rank : 177)
Query Neighborhood Hits	1044	Target Neighborhood Hits	915	Shared Neighborhood Hits	780
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

MK13_HUMAN
θ value	2.43908e-13 (rank : 323)	NC score	0.890696 (rank : 314)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	774
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MKNK2_HUMAN
θ value	2.43908e-13 (rank : 324)	NC score	0.905417 (rank : 205)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	767
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MYO3A_MOUSE
θ value	2.43908e-13 (rank : 325)	NC score	0.803482 (rank : 557)
Query Neighborhood Hits	1044	Target Neighborhood Hits	902	Shared Neighborhood Hits	800
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

EPHA8_MOUSE
θ value	3.18553e-13 (rank : 326)	NC score	0.705838 (rank : 697)
Query Neighborhood Hits	1044	Target Neighborhood Hits	969	Shared Neighborhood Hits	749
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

KPCA_HUMAN
θ value	3.18553e-13 (rank : 327)	NC score	0.859890 (rank : 458)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1070	Shared Neighborhood Hits	777
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	3.18553e-13 (rank : 328)	NC score	0.860965 (rank : 452)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1067	Shared Neighborhood Hits	774
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCL_MOUSE
θ value	3.18553e-13 (rank : 329)	NC score	0.882000 (rank : 370)
Query Neighborhood Hits	1044	Target Neighborhood Hits	891	Shared Neighborhood Hits	766
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MK13_MOUSE
θ value	3.18553e-13 (rank : 330)	NC score	0.891173 (rank : 313)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	775
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MP2K2_MOUSE
θ value	3.18553e-13 (rank : 331)	NC score	0.901225 (rank : 240)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	776
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PRKX_HUMAN
θ value	3.18553e-13 (rank : 332)	NC score	0.904435 (rank : 214)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	779
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKY_HUMAN
θ value	3.18553e-13 (rank : 333)	NC score	0.912162 (rank : 151)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	779
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

TAOK1_MOUSE
θ value	3.18553e-13 (rank : 334)	NC score	0.861752 (rank : 450)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1720	Shared Neighborhood Hits	965
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

CTRO_MOUSE
θ value	4.16044e-13 (rank : 335)	NC score	0.798744 (rank : 562)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2344	Shared Neighborhood Hits	963
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

KS6A1_MOUSE
θ value	4.16044e-13 (rank : 336)	NC score	0.902701 (rank : 231)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	780
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

M3K11_HUMAN
θ value	4.16044e-13 (rank : 337)	NC score	0.835555 (rank : 523)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1136	Shared Neighborhood Hits	789
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PRKX_MOUSE
θ value	4.16044e-13 (rank : 338)	NC score	0.905412 (rank : 206)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	781
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

TAOK1_HUMAN
θ value	4.16044e-13 (rank : 339)	NC score	0.861384 (rank : 451)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1734	Shared Neighborhood Hits	965
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

EPHA4_HUMAN
θ value	5.43371e-13 (rank : 340)	NC score	0.713765 (rank : 678)
Query Neighborhood Hits	1044	Target Neighborhood Hits	975	Shared Neighborhood Hits	755
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	5.43371e-13 (rank : 341)	NC score	0.713466 (rank : 680)
Query Neighborhood Hits	1044	Target Neighborhood Hits	982	Shared Neighborhood Hits	755
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA7_HUMAN
θ value	5.43371e-13 (rank : 342)	NC score	0.721800 (rank : 659)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1053	Shared Neighborhood Hits	763
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHB1_HUMAN
θ value	5.43371e-13 (rank : 343)	NC score	0.731939 (rank : 637)
Query Neighborhood Hits	1044	Target Neighborhood Hits	988	Shared Neighborhood Hits	755
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

HIPK4_HUMAN
θ value	5.43371e-13 (rank : 344)	NC score	0.874188 (rank : 415)
Query Neighborhood Hits	1044	Target Neighborhood Hits	799	Shared Neighborhood Hits	743
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

KPCT_MOUSE
θ value	5.43371e-13 (rank : 345)	NC score	0.885564 (rank : 342)
Query Neighborhood Hits	1044	Target Neighborhood Hits	895	Shared Neighborhood Hits	779
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KS6A2_MOUSE
θ value	5.43371e-13 (rank : 346)	NC score	0.906969 (rank : 191)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	784
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

MOK_HUMAN
θ value	5.43371e-13 (rank : 347)	NC score	0.872133 (rank : 424)
Query Neighborhood Hits	1044	Target Neighborhood Hits	807	Shared Neighborhood Hits	750
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

STK24_HUMAN
θ value	5.43371e-13 (rank : 348)	NC score	0.896472 (rank : 275)
Query Neighborhood Hits	1044	Target Neighborhood Hits	853	Shared Neighborhood Hits	783
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

CD2L1_MOUSE
θ value	7.09661e-13 (rank : 349)	NC score	0.874983 (rank : 408)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1463	Shared Neighborhood Hits	888
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CDK2_HUMAN
θ value	7.09661e-13 (rank : 350)	NC score	0.899029 (rank : 259)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	775
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

M3K7_HUMAN
θ value	7.09661e-13 (rank : 351)	NC score	0.859230 (rank : 462)
Query Neighborhood Hits	1044	Target Neighborhood Hits	892	Shared Neighborhood Hits	793
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	7.09661e-13 (rank : 352)	NC score	0.859420 (rank : 461)
Query Neighborhood Hits	1044	Target Neighborhood Hits	892	Shared Neighborhood Hits	794
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MAPK3_MOUSE
θ value	7.09661e-13 (rank : 353)	NC score	0.905527 (rank : 204)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	754
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

TRIO_HUMAN
θ value	7.09661e-13 (rank : 354)	NC score	0.842204 (rank : 502)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1580	Shared Neighborhood Hits	886
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

EPHA5_HUMAN
θ value	9.26847e-13 (rank : 355)	NC score	0.720700 (rank : 665)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	761
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	9.26847e-13 (rank : 356)	NC score	0.736680 (rank : 632)
Query Neighborhood Hits	1044	Target Neighborhood Hits	950	Shared Neighborhood Hits	758
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

LATS2_MOUSE
θ value	9.26847e-13 (rank : 357)	NC score	0.857594 (rank : 471)
Query Neighborhood Hits	1044	Target Neighborhood Hits	879	Shared Neighborhood Hits	769
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

M3K4_MOUSE
θ value	9.26847e-13 (rank : 358)	NC score	0.911121 (rank : 160)
Query Neighborhood Hits	1044	Target Neighborhood Hits	924	Shared Neighborhood Hits	792
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

MRCKA_HUMAN
θ value	9.26847e-13 (rank : 359)	NC score	0.819025 (rank : 537)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1999	Shared Neighborhood Hits	965
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

NEK2_MOUSE
θ value	9.26847e-13 (rank : 360)	NC score	0.921788 (rank : 109)
Query Neighborhood Hits	1044	Target Neighborhood Hits	876	Shared Neighborhood Hits	781
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

PAK7_MOUSE
θ value	9.26847e-13 (rank : 361)	NC score	0.908475 (rank : 178)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	783
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

KPCE_HUMAN
θ value	1.2105e-12 (rank : 362)	NC score	0.882969 (rank : 360)
Query Neighborhood Hits	1044	Target Neighborhood Hits	906	Shared Neighborhood Hits	769
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MK11_HUMAN
θ value	1.2105e-12 (rank : 363)	NC score	0.881377 (rank : 377)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	769
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

MP2K4_HUMAN
θ value	1.2105e-12 (rank : 364)	NC score	0.884820 (rank : 344)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	776
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	1.2105e-12 (rank : 365)	NC score	0.884643 (rank : 345)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	776
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

PAK7_HUMAN
θ value	1.2105e-12 (rank : 366)	NC score	0.908316 (rank : 179)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	781
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

CCRK_MOUSE
θ value	1.58096e-12 (rank : 367)	NC score	0.890492 (rank : 315)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	774
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CD2L1_HUMAN
θ value	1.58096e-12 (rank : 368)	NC score	0.874351 (rank : 414)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1467	Shared Neighborhood Hits	892
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CDK3_HUMAN
θ value	1.58096e-12 (rank : 369)	NC score	0.899063 (rank : 258)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	777
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

SPEG_MOUSE
θ value	1.58096e-12 (rank : 370)	NC score	0.823047 (rank : 536)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1959	Shared Neighborhood Hits	792
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

STK10_MOUSE
θ value	1.58096e-12 (rank : 371)	NC score	0.849540 (rank : 490)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2132	Shared Neighborhood Hits	984
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK24_MOUSE
θ value	1.58096e-12 (rank : 372)	NC score	0.895672 (rank : 281)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	783
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

ARBK1_HUMAN
θ value	2.0648e-12 (rank : 373)	NC score	0.881227 (rank : 379)
Query Neighborhood Hits	1044	Target Neighborhood Hits	859	Shared Neighborhood Hits	774
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	2.0648e-12 (rank : 374)	NC score	0.879882 (rank : 386)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	775
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

CD2L2_HUMAN
θ value	2.0648e-12 (rank : 375)	NC score	0.875355 (rank : 405)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1439	Shared Neighborhood Hits	885
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

EPHA2_HUMAN
θ value	2.0648e-12 (rank : 376)	NC score	0.718703 (rank : 667)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1021	Shared Neighborhood Hits	762
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

ITK_MOUSE
θ value	2.0648e-12 (rank : 377)	NC score	0.759840 (rank : 600)
Query Neighborhood Hits	1044	Target Neighborhood Hits	985	Shared Neighborhood Hits	774
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

TSSK6_MOUSE
θ value	2.0648e-12 (rank : 378)	NC score	0.921537 (rank : 110)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	765
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

CDK2_MOUSE
θ value	2.69671e-12 (rank : 379)	NC score	0.897429 (rank : 266)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	773
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

EPHB2_HUMAN
θ value	2.69671e-12 (rank : 380)	NC score	0.715560 (rank : 675)
Query Neighborhood Hits	1044	Target Neighborhood Hits	983	Shared Neighborhood Hits	756
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	2.69671e-12 (rank : 381)	NC score	0.715717 (rank : 674)
Query Neighborhood Hits	1044	Target Neighborhood Hits	982	Shared Neighborhood Hits	756
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

M3K13_HUMAN
θ value	2.69671e-12 (rank : 382)	NC score	0.863583 (rank : 444)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	786
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K6_HUMAN
θ value	2.69671e-12 (rank : 383)	NC score	0.910210 (rank : 169)
Query Neighborhood Hits	1044	Target Neighborhood Hits	889	Shared Neighborhood Hits	781
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

MAK_HUMAN
θ value	2.69671e-12 (rank : 384)	NC score	0.894500 (rank : 287)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	775
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MAK_MOUSE
θ value	2.69671e-12 (rank : 385)	NC score	0.895901 (rank : 280)
Query Neighborhood Hits	1044	Target Neighborhood Hits	873	Shared Neighborhood Hits	776
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

MKNK1_HUMAN
θ value	2.69671e-12 (rank : 386)	NC score	0.854529 (rank : 477)
Query Neighborhood Hits	1044	Target Neighborhood Hits	701	Shared Neighborhood Hits	670
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

ROCK1_HUMAN
θ value	2.69671e-12 (rank : 387)	NC score	0.814161 (rank : 543)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2000	Shared Neighborhood Hits	963
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	2.69671e-12 (rank : 388)	NC score	0.801286 (rank : 559)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2126	Shared Neighborhood Hits	972
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

STK10_HUMAN
θ value	2.69671e-12 (rank : 389)	NC score	0.867842 (rank : 441)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1921	Shared Neighborhood Hits	972
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

DYR1A_HUMAN
θ value	3.52202e-12 (rank : 390)	NC score	0.847171 (rank : 494)
Query Neighborhood Hits	1044	Target Neighborhood Hits	764	Shared Neighborhood Hits	719
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	3.52202e-12 (rank : 391)	NC score	0.847170 (rank : 495)
Query Neighborhood Hits	1044	Target Neighborhood Hits	762	Shared Neighborhood Hits	719
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1B_MOUSE
θ value	3.52202e-12 (rank : 392)	NC score	0.860609 (rank : 453)
Query Neighborhood Hits	1044	Target Neighborhood Hits	799	Shared Neighborhood Hits	730
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

EPHA1_HUMAN
θ value	3.52202e-12 (rank : 393)	NC score	0.713658 (rank : 679)
Query Neighborhood Hits	1044	Target Neighborhood Hits	997	Shared Neighborhood Hits	748
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

KPCB_HUMAN
θ value	3.52202e-12 (rank : 394)	NC score	0.850996 (rank : 483)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1121	Shared Neighborhood Hits	778
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

ITK_HUMAN
θ value	4.59992e-12 (rank : 395)	NC score	0.759693 (rank : 601)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1016	Shared Neighborhood Hits	772
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

PKN2_HUMAN
θ value	4.59992e-12 (rank : 396)	NC score	0.886439 (rank : 334)
Query Neighborhood Hits	1044	Target Neighborhood Hits	892	Shared Neighborhood Hits	794
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

M3K4_HUMAN
θ value	6.00763e-12 (rank : 397)	NC score	0.911202 (rank : 158)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	793
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

PKN2_MOUSE
θ value	6.00763e-12 (rank : 398)	NC score	0.886458 (rank : 333)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	793
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

SPEG_HUMAN
θ value	6.00763e-12 (rank : 399)	NC score	0.827498 (rank : 533)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1762	Shared Neighborhood Hits	790
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TSSK6_HUMAN
θ value	6.00763e-12 (rank : 400)	NC score	0.920989 (rank : 117)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	767
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

CDK9_HUMAN
θ value	7.84624e-12 (rank : 401)	NC score	0.884325 (rank : 349)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	769
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	7.84624e-12 (rank : 402)	NC score	0.883865 (rank : 351)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	769
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

DYR1B_HUMAN
θ value	7.84624e-12 (rank : 403)	NC score	0.857770 (rank : 470)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	729
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

MAPK3_HUMAN
θ value	7.84624e-12 (rank : 404)	NC score	0.903603 (rank : 221)
Query Neighborhood Hits	1044	Target Neighborhood Hits	807	Shared Neighborhood Hits	747
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

PAK4_HUMAN
θ value	7.84624e-12 (rank : 405)	NC score	0.906293 (rank : 199)
Query Neighborhood Hits	1044	Target Neighborhood Hits	924	Shared Neighborhood Hits	781
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

CTRO_HUMAN
θ value	1.02475e-11 (rank : 406)	NC score	0.815378 (rank : 541)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2092	Shared Neighborhood Hits	959
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

EPHA6_MOUSE
θ value	1.02475e-11 (rank : 407)	NC score	0.674347 (rank : 744)
Query Neighborhood Hits	1044	Target Neighborhood Hits	946	Shared Neighborhood Hits	750
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

KPCT_HUMAN
θ value	1.02475e-11 (rank : 408)	NC score	0.886286 (rank : 336)
Query Neighborhood Hits	1044	Target Neighborhood Hits	897	Shared Neighborhood Hits	781
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MP2K5_HUMAN
θ value	1.02475e-11 (rank : 409)	NC score	0.892665 (rank : 300)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	777
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MRCKG_HUMAN
θ value	1.02475e-11 (rank : 410)	NC score	0.855093 (rank : 475)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1519	Shared Neighborhood Hits	916
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

RK_MOUSE
θ value	1.02475e-11 (rank : 411)	NC score	0.888101 (rank : 324)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	773
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

SRMS_MOUSE
θ value	1.02475e-11 (rank : 412)	NC score	0.753281 (rank : 610)
Query Neighborhood Hits	1044	Target Neighborhood Hits	964	Shared Neighborhood Hits	775
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

RIPK4_HUMAN
θ value	1.33837e-11 (rank : 413)	NC score	0.658548 (rank : 765)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1094	Shared Neighborhood Hits	749
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

YSK4_HUMAN
θ value	1.33837e-11 (rank : 414)	NC score	0.897973 (rank : 265)
Query Neighborhood Hits	1044	Target Neighborhood Hits	921	Shared Neighborhood Hits	788
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

CDK10_HUMAN
θ value	1.74796e-11 (rank : 415)	NC score	0.882066 (rank : 369)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	771
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

EPHA6_HUMAN
θ value	1.74796e-11 (rank : 416)	NC score	0.668448 (rank : 757)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	745
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

PKN1_HUMAN
θ value	1.74796e-11 (rank : 417)	NC score	0.882440 (rank : 367)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	784
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	1.74796e-11 (rank : 418)	NC score	0.883205 (rank : 357)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	788
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN3_HUMAN
θ value	1.74796e-11 (rank : 419)	NC score	0.883672 (rank : 352)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	787
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

ROCK2_HUMAN
θ value	1.74796e-11 (rank : 420)	NC score	0.816954 (rank : 540)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2073	Shared Neighborhood Hits	969
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

EPHA2_MOUSE
θ value	2.28291e-11 (rank : 421)	NC score	0.716528 (rank : 673)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1020	Shared Neighborhood Hits	758
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

GRK7_HUMAN
θ value	2.28291e-11 (rank : 422)	NC score	0.892305 (rank : 304)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	772
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

CDKL2_MOUSE
θ value	2.98157e-11 (rank : 423)	NC score	0.902576 (rank : 232)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	775
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

EPHB3_MOUSE
θ value	2.98157e-11 (rank : 424)	NC score	0.703689 (rank : 700)
Query Neighborhood Hits	1044	Target Neighborhood Hits	996	Shared Neighborhood Hits	759
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

KPCB_MOUSE
θ value	2.98157e-11 (rank : 425)	NC score	0.850967 (rank : 484)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1117	Shared Neighborhood Hits	778
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

M3K12_HUMAN
θ value	2.98157e-11 (rank : 426)	NC score	0.852706 (rank : 480)
Query Neighborhood Hits	1044	Target Neighborhood Hits	940	Shared Neighborhood Hits	785
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	2.98157e-11 (rank : 427)	NC score	0.852796 (rank : 479)
Query Neighborhood Hits	1044	Target Neighborhood Hits	957	Shared Neighborhood Hits	786
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

CDKL3_MOUSE
θ value	3.89403e-11 (rank : 428)	NC score	0.908002 (rank : 183)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	775
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

ROCK2_MOUSE
θ value	3.89403e-11 (rank : 429)	NC score	0.810973 (rank : 548)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2072	Shared Neighborhood Hits	970
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

STK11_HUMAN
θ value	3.89403e-11 (rank : 430)	NC score	0.924032 (rank : 84)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	773
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

DUET_HUMAN
θ value	5.08577e-11 (rank : 431)	NC score	0.837247 (rank : 515)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1220	Shared Neighborhood Hits	761
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

FAK1_MOUSE
θ value	5.08577e-11 (rank : 432)	NC score	0.763240 (rank : 597)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	763
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

JAK2_MOUSE
θ value	5.08577e-11 (rank : 433)	NC score	0.797759 (rank : 565)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	768
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

KPCL_HUMAN
θ value	5.08577e-11 (rank : 434)	NC score	0.879637 (rank : 389)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	766
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

M4K2_MOUSE
θ value	5.08577e-11 (rank : 435)	NC score	0.881737 (rank : 374)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	773
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

MK07_HUMAN
θ value	5.08577e-11 (rank : 436)	NC score	0.883558 (rank : 354)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1087	Shared Neighborhood Hits	783
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	5.08577e-11 (rank : 437)	NC score	0.884618 (rank : 346)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1054	Shared Neighborhood Hits	786
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

RIPK1_HUMAN
θ value	5.08577e-11 (rank : 438)	NC score	0.849580 (rank : 489)
Query Neighborhood Hits	1044	Target Neighborhood Hits	891	Shared Neighborhood Hits	783
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

FAK1_HUMAN
θ value	6.64225e-11 (rank : 439)	NC score	0.763320 (rank : 596)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	762
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK2_MOUSE
θ value	6.64225e-11 (rank : 440)	NC score	0.754690 (rank : 606)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	755
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TEC_MOUSE
θ value	6.64225e-11 (rank : 441)	NC score	0.769150 (rank : 589)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1006	Shared Neighborhood Hits	769
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

CDK4_HUMAN
θ value	8.67504e-11 (rank : 442)	NC score	0.881788 (rank : 373)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	769
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

CDK4_MOUSE
θ value	8.67504e-11 (rank : 443)	NC score	0.883640 (rank : 353)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	769
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

GAK_HUMAN
θ value	8.67504e-11 (rank : 444)	NC score	0.857205 (rank : 472)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1028	Shared Neighborhood Hits	771
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

NTRK2_HUMAN
θ value	8.67504e-11 (rank : 445)	NC score	0.721278 (rank : 661)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1081	Shared Neighborhood Hits	758
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	8.67504e-11 (rank : 446)	NC score	0.721076 (rank : 662)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1088	Shared Neighborhood Hits	758
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

CDKL3_HUMAN
θ value	1.133e-10 (rank : 447)	NC score	0.907391 (rank : 186)
Query Neighborhood Hits	1044	Target Neighborhood Hits	853	Shared Neighborhood Hits	777
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

NLK_HUMAN
θ value	1.133e-10 (rank : 448)	NC score	0.886755 (rank : 328)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	775
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	1.133e-10 (rank : 449)	NC score	0.886740 (rank : 329)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	775
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

PAK4_MOUSE
θ value	1.133e-10 (rank : 450)	NC score	0.903212 (rank : 226)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1098	Shared Neighborhood Hits	785
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PASK_MOUSE
θ value	1.133e-10 (rank : 451)	NC score	0.921924 (rank : 106)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	774
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PDK1L_MOUSE
θ value	1.133e-10 (rank : 452)	NC score	0.903449 (rank : 224)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	770
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

EPHB3_HUMAN
θ value	1.47974e-10 (rank : 453)	NC score	0.704490 (rank : 699)
Query Neighborhood Hits	1044	Target Neighborhood Hits	996	Shared Neighborhood Hits	757
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

LCK_MOUSE
θ value	1.47974e-10 (rank : 454)	NC score	0.746489 (rank : 623)
Query Neighborhood Hits	1044	Target Neighborhood Hits	981	Shared Neighborhood Hits	775
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

MRCKG_MOUSE
θ value	1.47974e-10 (rank : 455)	NC score	0.854659 (rank : 476)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1466	Shared Neighborhood Hits	928
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PDK1L_HUMAN
θ value	1.47974e-10 (rank : 456)	NC score	0.903625 (rank : 220)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	770
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

RK_HUMAN
θ value	1.47974e-10 (rank : 457)	NC score	0.885442 (rank : 343)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	775
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

TXK_HUMAN
θ value	1.47974e-10 (rank : 458)	NC score	0.760375 (rank : 599)
Query Neighborhood Hits	1044	Target Neighborhood Hits	971	Shared Neighborhood Hits	764
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

CDKL2_HUMAN
θ value	1.9326e-10 (rank : 459)	NC score	0.900780 (rank : 246)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	778
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDKL5_HUMAN
θ value	1.9326e-10 (rank : 460)	NC score	0.901052 (rank : 242)
Query Neighborhood Hits	1044	Target Neighborhood Hits	967	Shared Neighborhood Hits	784
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

DMPK_MOUSE
θ value	1.9326e-10 (rank : 461)	NC score	0.872648 (rank : 422)
Query Neighborhood Hits	1044	Target Neighborhood Hits	908	Shared Neighborhood Hits	802
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DYRK4_HUMAN
θ value	1.9326e-10 (rank : 462)	NC score	0.840322 (rank : 509)
Query Neighborhood Hits	1044	Target Neighborhood Hits	750	Shared Neighborhood Hits	712
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

RAF1_HUMAN
θ value	1.9326e-10 (rank : 463)	NC score	0.842097 (rank : 503)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	781
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

TNIK_HUMAN
θ value	1.9326e-10 (rank : 464)	NC score	0.871580 (rank : 429)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1570	Shared Neighborhood Hits	919
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TXK_MOUSE
θ value	1.9326e-10 (rank : 465)	NC score	0.748259 (rank : 620)
Query Neighborhood Hits	1044	Target Neighborhood Hits	980	Shared Neighborhood Hits	756
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

DDR2_HUMAN
θ value	2.52405e-10 (rank : 466)	NC score	0.700662 (rank : 709)
Query Neighborhood Hits	1044	Target Neighborhood Hits	818	Shared Neighborhood Hits	731
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

FAK2_HUMAN
θ value	2.52405e-10 (rank : 467)	NC score	0.749039 (rank : 616)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	755
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

RIPK2_MOUSE
θ value	2.52405e-10 (rank : 468)	NC score	0.797839 (rank : 564)
Query Neighborhood Hits	1044	Target Neighborhood Hits	776	Shared Neighborhood Hits	709
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

E2AK2_MOUSE
θ value	3.29651e-10 (rank : 469)	NC score	0.912080 (rank : 152)
Query Neighborhood Hits	1044	Target Neighborhood Hits	864	Shared Neighborhood Hits	782
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

FER_HUMAN
θ value	3.29651e-10 (rank : 470)	NC score	0.768318 (rank : 592)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1278	Shared Neighborhood Hits	870
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FYN_HUMAN
θ value	3.29651e-10 (rank : 471)	NC score	0.741301 (rank : 627)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1078	Shared Neighborhood Hits	776
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

IRAK3_MOUSE
θ value	3.29651e-10 (rank : 472)	NC score	0.685569 (rank : 728)
Query Neighborhood Hits	1044	Target Neighborhood Hits	628	Shared Neighborhood Hits	570
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

M4K2_HUMAN
θ value	3.29651e-10 (rank : 473)	NC score	0.880748 (rank : 382)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	773
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

MP2K6_HUMAN
θ value	3.29651e-10 (rank : 474)	NC score	0.879520 (rank : 391)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	774
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

PASK_HUMAN
θ value	3.29651e-10 (rank : 475)	NC score	0.916907 (rank : 136)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	769
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

RAF1_MOUSE
θ value	3.29651e-10 (rank : 476)	NC score	0.841727 (rank : 505)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	781
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

FYN_MOUSE
θ value	4.30538e-10 (rank : 477)	NC score	0.737011 (rank : 631)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1073	Shared Neighborhood Hits	779
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GAK_MOUSE
θ value	4.30538e-10 (rank : 478)	NC score	0.852123 (rank : 481)
Query Neighborhood Hits	1044	Target Neighborhood Hits	964	Shared Neighborhood Hits	761
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

HIPK3_HUMAN
θ value	4.30538e-10 (rank : 479)	NC score	0.845179 (rank : 499)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	747
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

JAK2_HUMAN
θ value	4.30538e-10 (rank : 480)	NC score	0.798986 (rank : 561)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	772
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

STK35_HUMAN
θ value	4.30538e-10 (rank : 481)	NC score	0.896183 (rank : 277)
Query Neighborhood Hits	1044	Target Neighborhood Hits	825	Shared Neighborhood Hits	771
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

TEC_HUMAN
θ value	4.30538e-10 (rank : 482)	NC score	0.763029 (rank : 598)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1006	Shared Neighborhood Hits	768
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ABL2_HUMAN
θ value	5.62301e-10 (rank : 483)	NC score	0.753018 (rank : 611)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1045	Shared Neighborhood Hits	768
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

DDR2_MOUSE
θ value	5.62301e-10 (rank : 484)	NC score	0.707107 (rank : 693)
Query Neighborhood Hits	1044	Target Neighborhood Hits	813	Shared Neighborhood Hits	732
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ERBB4_HUMAN
θ value	5.62301e-10 (rank : 485)	NC score	0.723748 (rank : 652)
Query Neighborhood Hits	1044	Target Neighborhood Hits	910	Shared Neighborhood Hits	750
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ERN2_MOUSE
θ value	5.62301e-10 (rank : 486)	NC score	0.862531 (rank : 449)
Query Neighborhood Hits	1044	Target Neighborhood Hits	825	Shared Neighborhood Hits	767
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

HIPK1_HUMAN
θ value	5.62301e-10 (rank : 487)	NC score	0.845557 (rank : 497)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	739
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	5.62301e-10 (rank : 488)	NC score	0.845551 (rank : 498)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	740
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HIPK3_MOUSE
θ value	5.62301e-10 (rank : 489)	NC score	0.847051 (rank : 496)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	748
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

KPCG_MOUSE
θ value	5.62301e-10 (rank : 490)	NC score	0.851155 (rank : 482)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1123	Shared Neighborhood Hits	772
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

M3KL4_HUMAN
θ value	5.62301e-10 (rank : 491)	NC score	0.823415 (rank : 535)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1087	Shared Neighborhood Hits	807
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

OXSR1_HUMAN
θ value	5.62301e-10 (rank : 492)	NC score	0.893006 (rank : 295)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	782
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

DYRK3_HUMAN
θ value	7.34386e-10 (rank : 493)	NC score	0.858926 (rank : 465)
Query Neighborhood Hits	1044	Target Neighborhood Hits	798	Shared Neighborhood Hits	742
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

KPCD_MOUSE
θ value	7.34386e-10 (rank : 494)	NC score	0.874912 (rank : 409)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	772
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCG_HUMAN
θ value	7.34386e-10 (rank : 495)	NC score	0.850769 (rank : 485)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1126	Shared Neighborhood Hits	772
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

OXSR1_MOUSE
θ value	7.34386e-10 (rank : 496)	NC score	0.892998 (rank : 296)
Query Neighborhood Hits	1044	Target Neighborhood Hits	865	Shared Neighborhood Hits	783
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK39_HUMAN
θ value	7.34386e-10 (rank : 497)	NC score	0.892219 (rank : 306)
Query Neighborhood Hits	1044	Target Neighborhood Hits	882	Shared Neighborhood Hits	784
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	7.34386e-10 (rank : 498)	NC score	0.891958 (rank : 309)
Query Neighborhood Hits	1044	Target Neighborhood Hits	915	Shared Neighborhood Hits	786
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

FGR_HUMAN
θ value	9.59137e-10 (rank : 499)	NC score	0.723769 (rank : 651)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1067	Shared Neighborhood Hits	773
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

MP2K6_MOUSE
θ value	9.59137e-10 (rank : 500)	NC score	0.879632 (rank : 390)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	775
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MST4_HUMAN
θ value	9.59137e-10 (rank : 501)	NC score	0.892551 (rank : 302)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	782
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MYO3B_HUMAN
θ value	9.59137e-10 (rank : 502)	NC score	0.788496 (rank : 571)
Query Neighborhood Hits	1044	Target Neighborhood Hits	923	Shared Neighborhood Hits	806
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

RIPK3_MOUSE
θ value	9.59137e-10 (rank : 503)	NC score	0.847891 (rank : 492)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	755
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

DYRK2_HUMAN
θ value	1.25267e-09 (rank : 504)	NC score	0.858048 (rank : 468)
Query Neighborhood Hits	1044	Target Neighborhood Hits	799	Shared Neighborhood Hits	742
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

FES_HUMAN
θ value	1.25267e-09 (rank : 505)	NC score	0.779240 (rank : 577)
Query Neighborhood Hits	1044	Target Neighborhood Hits	978	Shared Neighborhood Hits	780
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

MST4_MOUSE
θ value	1.25267e-09 (rank : 506)	NC score	0.892562 (rank : 301)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	782
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

STK25_HUMAN
θ value	1.25267e-09 (rank : 507)	NC score	0.892867 (rank : 298)
Query Neighborhood Hits	1044	Target Neighborhood Hits	853	Shared Neighborhood Hits	782
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

DMPK_HUMAN
θ value	1.63604e-09 (rank : 508)	NC score	0.871682 (rank : 426)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	807
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

IRAK3_HUMAN
θ value	1.63604e-09 (rank : 509)	NC score	0.690187 (rank : 722)
Query Neighborhood Hits	1044	Target Neighborhood Hits	644	Shared Neighborhood Hits	591
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

LCK_HUMAN
θ value	1.63604e-09 (rank : 510)	NC score	0.740872 (rank : 629)
Query Neighborhood Hits	1044	Target Neighborhood Hits	987	Shared Neighborhood Hits	775
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

M3K1_MOUSE
θ value	1.63604e-09 (rank : 511)	NC score	0.911703 (rank : 155)
Query Neighborhood Hits	1044	Target Neighborhood Hits	952	Shared Neighborhood Hits	787
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M4K1_MOUSE
θ value	1.63604e-09 (rank : 512)	NC score	0.879831 (rank : 387)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	781
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

MP2K7_HUMAN
θ value	1.63604e-09 (rank : 513)	NC score	0.894888 (rank : 285)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	773
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

PKN3_MOUSE
θ value	1.63604e-09 (rank : 514)	NC score	0.882799 (rank : 364)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	806
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

RIPK2_HUMAN
θ value	1.63604e-09 (rank : 515)	NC score	0.798543 (rank : 563)
Query Neighborhood Hits	1044	Target Neighborhood Hits	774	Shared Neighborhood Hits	709
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

SBK1_HUMAN
θ value	1.63604e-09 (rank : 516)	NC score	0.910209 (rank : 170)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	758
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

STK25_MOUSE
θ value	1.63604e-09 (rank : 517)	NC score	0.892207 (rank : 307)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	782
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

ARAF_MOUSE
θ value	2.13673e-09 (rank : 518)	NC score	0.835773 (rank : 521)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	775
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

HCK_MOUSE
θ value	2.13673e-09 (rank : 519)	NC score	0.733512 (rank : 635)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1029	Shared Neighborhood Hits	774
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HIPK2_HUMAN
θ value	2.13673e-09 (rank : 520)	NC score	0.841790 (rank : 504)
Query Neighborhood Hits	1044	Target Neighborhood Hits	845	Shared Neighborhood Hits	741
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	2.13673e-09 (rank : 521)	NC score	0.841446 (rank : 507)
Query Neighborhood Hits	1044	Target Neighborhood Hits	871	Shared Neighborhood Hits	741
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

LYN_HUMAN
θ value	2.13673e-09 (rank : 522)	NC score	0.753932 (rank : 609)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1022	Shared Neighborhood Hits	783
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MASTL_HUMAN
θ value	2.13673e-09 (rank : 523)	NC score	0.888197 (rank : 322)
Query Neighborhood Hits	1044	Target Neighborhood Hits	894	Shared Neighborhood Hits	778
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

SRMS_HUMAN
θ value	2.13673e-09 (rank : 524)	NC score	0.746573 (rank : 622)
Query Neighborhood Hits	1044	Target Neighborhood Hits	946	Shared Neighborhood Hits	771
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

DDR1_HUMAN
θ value	2.79066e-09 (rank : 525)	NC score	0.673488 (rank : 747)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	724
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

LYN_MOUSE
θ value	2.79066e-09 (rank : 526)	NC score	0.754368 (rank : 608)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1023	Shared Neighborhood Hits	783
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PTK7_HUMAN
θ value	2.79066e-09 (rank : 527)	NC score	0.652572 (rank : 772)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1103	Shared Neighborhood Hits	734
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

SBK1_MOUSE
θ value	2.79066e-09 (rank : 528)	NC score	0.911041 (rank : 161)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	756
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

M4K3_HUMAN
θ value	3.64472e-09 (rank : 529)	NC score	0.883169 (rank : 358)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	779
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MASTL_MOUSE
θ value	3.64472e-09 (rank : 530)	NC score	0.886543 (rank : 332)
Query Neighborhood Hits	1044	Target Neighborhood Hits	862	Shared Neighborhood Hits	779
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

RET_HUMAN
θ value	3.64472e-09 (rank : 531)	NC score	0.723666 (rank : 653)
Query Neighborhood Hits	1044	Target Neighborhood Hits	873	Shared Neighborhood Hits	758
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ARAF_HUMAN
θ value	4.76016e-09 (rank : 532)	NC score	0.836050 (rank : 518)
Query Neighborhood Hits	1044	Target Neighborhood Hits	924	Shared Neighborhood Hits	776
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

BMP2K_HUMAN
θ value	4.76016e-09 (rank : 533)	NC score	0.859643 (rank : 460)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	747
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

KPCD_HUMAN
θ value	4.76016e-09 (rank : 534)	NC score	0.877113 (rank : 399)
Query Neighborhood Hits	1044	Target Neighborhood Hits	900	Shared Neighborhood Hits	775
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

TITIN_HUMAN
θ value	4.76016e-09 (rank : 535)	NC score	0.702782 (rank : 705)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2923	Shared Neighborhood Hits	878
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

FGR_MOUSE
θ value	6.21693e-09 (rank : 536)	NC score	0.721046 (rank : 664)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1069	Shared Neighborhood Hits	771
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ULK4_MOUSE
θ value	6.21693e-09 (rank : 537)	NC score	0.907480 (rank : 185)
Query Neighborhood Hits	1044	Target Neighborhood Hits	793	Shared Neighborhood Hits	728
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

ABL1_HUMAN
θ value	8.11959e-09 (rank : 538)	NC score	0.754669 (rank : 607)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1220	Shared Neighborhood Hits	774
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ERN2_HUMAN
θ value	8.11959e-09 (rank : 539)	NC score	0.863520 (rank : 445)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	766
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FES_MOUSE
θ value	8.11959e-09 (rank : 540)	NC score	0.780525 (rank : 576)
Query Neighborhood Hits	1044	Target Neighborhood Hits	980	Shared Neighborhood Hits	798
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

GRK6_HUMAN
θ value	8.11959e-09 (rank : 541)	NC score	0.883388 (rank : 355)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	768
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

NTRK1_HUMAN
θ value	8.11959e-09 (rank : 542)	NC score	0.694957 (rank : 715)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1023	Shared Neighborhood Hits	741
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

STK40_HUMAN
θ value	8.11959e-09 (rank : 543)	NC score	0.860555 (rank : 455)
Query Neighborhood Hits	1044	Target Neighborhood Hits	751	Shared Neighborhood Hits	708
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	8.11959e-09 (rank : 544)	NC score	0.860219 (rank : 457)
Query Neighborhood Hits	1044	Target Neighborhood Hits	751	Shared Neighborhood Hits	708
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

ABL1_MOUSE
θ value	1.06045e-08 (rank : 545)	NC score	0.755213 (rank : 605)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1178	Shared Neighborhood Hits	776
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

EPHB4_MOUSE
θ value	1.06045e-08 (rank : 546)	NC score	0.718300 (rank : 668)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1013	Shared Neighborhood Hits	750
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

M4K1_HUMAN
θ value	1.06045e-08 (rank : 547)	NC score	0.879169 (rank : 393)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	780
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

CDK3_MOUSE
θ value	1.38499e-08 (rank : 548)	NC score	0.899545 (rank : 255)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	773
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

HCK_HUMAN
θ value	1.38499e-08 (rank : 549)	NC score	0.736267 (rank : 633)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1035	Shared Neighborhood Hits	773
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

BMP2K_MOUSE
θ value	1.80886e-08 (rank : 550)	NC score	0.859085 (rank : 463)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	745
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

EPHB4_HUMAN
θ value	1.80886e-08 (rank : 551)	NC score	0.714762 (rank : 676)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1056	Shared Neighborhood Hits	749
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

ERBB2_MOUSE
θ value	1.80886e-08 (rank : 552)	NC score	0.713264 (rank : 681)
Query Neighborhood Hits	1044	Target Neighborhood Hits	918	Shared Neighborhood Hits	760
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

RET_MOUSE
θ value	1.80886e-08 (rank : 553)	NC score	0.722469 (rank : 657)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	755
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIPK1_MOUSE
θ value	1.80886e-08 (rank : 554)	NC score	0.842369 (rank : 501)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	778
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

SRC_HUMAN
θ value	1.80886e-08 (rank : 555)	NC score	0.733427 (rank : 636)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1058	Shared Neighborhood Hits	770
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

YES_HUMAN
θ value	1.80886e-08 (rank : 556)	NC score	0.728156 (rank : 640)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1059	Shared Neighborhood Hits	766
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BTK_HUMAN
θ value	2.36244e-08 (rank : 557)	NC score	0.751536 (rank : 613)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1026	Shared Neighborhood Hits	759
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	2.36244e-08 (rank : 558)	NC score	0.751586 (rank : 612)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1017	Shared Neighborhood Hits	760
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CSK21_MOUSE
θ value	2.36244e-08 (rank : 559)	NC score	0.873894 (rank : 416)
Query Neighborhood Hits	1044	Target Neighborhood Hits	770	Shared Neighborhood Hits	733
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

MK09_HUMAN
θ value	2.36244e-08 (rank : 560)	NC score	0.878638 (rank : 394)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	776
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

SRC_MOUSE
θ value	2.36244e-08 (rank : 561)	NC score	0.734109 (rank : 634)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1033	Shared Neighborhood Hits	767
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

YES_MOUSE
θ value	2.36244e-08 (rank : 562)	NC score	0.727677 (rank : 642)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1052	Shared Neighborhood Hits	768
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

BLK_HUMAN
θ value	3.08544e-08 (rank : 563)	NC score	0.740914 (rank : 628)
Query Neighborhood Hits	1044	Target Neighborhood Hits	994	Shared Neighborhood Hits	775
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CSK21_HUMAN
θ value	3.08544e-08 (rank : 564)	NC score	0.873582 (rank : 418)
Query Neighborhood Hits	1044	Target Neighborhood Hits	772	Shared Neighborhood Hits	735
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

EGFR_HUMAN
θ value	3.08544e-08 (rank : 565)	NC score	0.721074 (rank : 663)
Query Neighborhood Hits	1044	Target Neighborhood Hits	939	Shared Neighborhood Hits	758
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

ERBB2_HUMAN
θ value	3.08544e-08 (rank : 566)	NC score	0.709551 (rank : 689)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1073	Shared Neighborhood Hits	764
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

GRK4_MOUSE
θ value	3.08544e-08 (rank : 567)	NC score	0.874745 (rank : 410)
Query Neighborhood Hits	1044	Target Neighborhood Hits	808	Shared Neighborhood Hits	758
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

KGP1A_HUMAN
θ value	3.08544e-08 (rank : 568)	NC score	0.883302 (rank : 356)
Query Neighborhood Hits	1044	Target Neighborhood Hits	901	Shared Neighborhood Hits	784
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	3.08544e-08 (rank : 569)	NC score	0.882795 (rank : 365)
Query Neighborhood Hits	1044	Target Neighborhood Hits	921	Shared Neighborhood Hits	787
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	3.08544e-08 (rank : 570)	NC score	0.882849 (rank : 363)
Query Neighborhood Hits	1044	Target Neighborhood Hits	922	Shared Neighborhood Hits	787
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

MP2K3_MOUSE
θ value	3.08544e-08 (rank : 571)	NC score	0.881100 (rank : 381)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	774
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PTK6_HUMAN
θ value	3.08544e-08 (rank : 572)	NC score	0.775458 (rank : 581)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1020	Shared Neighborhood Hits	774
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

EGFR_MOUSE
θ value	4.0297e-08 (rank : 573)	NC score	0.721860 (rank : 658)
Query Neighborhood Hits	1044	Target Neighborhood Hits	927	Shared Neighborhood Hits	759
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

FRK_HUMAN
θ value	4.0297e-08 (rank : 574)	NC score	0.750668 (rank : 615)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1058	Shared Neighborhood Hits	775
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

GRK5_HUMAN
θ value	4.0297e-08 (rank : 575)	NC score	0.879821 (rank : 388)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	763
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	4.0297e-08 (rank : 576)	NC score	0.880233 (rank : 383)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	763
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GSK3B_HUMAN
θ value	4.0297e-08 (rank : 577)	NC score	0.879896 (rank : 385)
Query Neighborhood Hits	1044	Target Neighborhood Hits	801	Shared Neighborhood Hits	752
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	4.0297e-08 (rank : 578)	NC score	0.879900 (rank : 384)
Query Neighborhood Hits	1044	Target Neighborhood Hits	800	Shared Neighborhood Hits	752
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

IRAK4_MOUSE
θ value	4.0297e-08 (rank : 579)	NC score	0.853367 (rank : 478)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	755
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

MET_MOUSE
θ value	4.0297e-08 (rank : 580)	NC score	0.708812 (rank : 690)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	747
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

AAK1_HUMAN
θ value	5.26297e-08 (rank : 581)	NC score	0.849645 (rank : 488)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1077	Shared Neighborhood Hits	754
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
θ value	5.26297e-08 (rank : 582)	NC score	0.849980 (rank : 487)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1051	Shared Neighborhood Hits	755
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

DDR1_MOUSE
θ value	5.26297e-08 (rank : 583)	NC score	0.673291 (rank : 748)
Query Neighborhood Hits	1044	Target Neighborhood Hits	818	Shared Neighborhood Hits	723
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

M3K8_MOUSE
θ value	5.26297e-08 (rank : 584)	NC score	0.886363 (rank : 335)
Query Neighborhood Hits	1044	Target Neighborhood Hits	815	Shared Neighborhood Hits	752
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MINK1_HUMAN
θ value	5.26297e-08 (rank : 585)	NC score	0.868190 (rank : 440)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1477	Shared Neighborhood Hits	914
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	5.26297e-08 (rank : 586)	NC score	0.868808 (rank : 436)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1451	Shared Neighborhood Hits	911
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MK09_MOUSE
θ value	5.26297e-08 (rank : 587)	NC score	0.875043 (rank : 407)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	773
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MP2K3_HUMAN
θ value	5.26297e-08 (rank : 588)	NC score	0.879476 (rank : 392)
Query Neighborhood Hits	1044	Target Neighborhood Hits	825	Shared Neighborhood Hits	774
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MUSK_MOUSE
θ value	5.26297e-08 (rank : 589)	NC score	0.638234 (rank : 781)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1057	Shared Neighborhood Hits	733
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

STK23_HUMAN
θ value	5.26297e-08 (rank : 590)	NC score	0.614797 (rank : 804)
Query Neighborhood Hits	1044	Target Neighborhood Hits	556	Shared Neighborhood Hits	550
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	5.26297e-08 (rank : 591)	NC score	0.615910 (rank : 802)
Query Neighborhood Hits	1044	Target Neighborhood Hits	572	Shared Neighborhood Hits	555
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

CSK22_HUMAN
θ value	6.87365e-08 (rank : 592)	NC score	0.863427 (rank : 446)
Query Neighborhood Hits	1044	Target Neighborhood Hits	758	Shared Neighborhood Hits	718
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

ERN1_HUMAN
θ value	6.87365e-08 (rank : 593)	NC score	0.871091 (rank : 430)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	767
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

GRK6_MOUSE
θ value	6.87365e-08 (rank : 594)	NC score	0.882477 (rank : 366)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	768
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MET_HUMAN
θ value	6.87365e-08 (rank : 595)	NC score	0.706902 (rank : 694)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	746
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

BMX_HUMAN
θ value	8.97725e-08 (rank : 596)	NC score	0.751173 (rank : 614)
Query Neighborhood Hits	1044	Target Neighborhood Hits	942	Shared Neighborhood Hits	753
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

SRPK2_HUMAN
θ value	8.97725e-08 (rank : 597)	NC score	0.613615 (rank : 806)
Query Neighborhood Hits	1044	Target Neighborhood Hits	664	Shared Neighborhood Hits	576
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	8.97725e-08 (rank : 598)	NC score	0.614789 (rank : 805)
Query Neighborhood Hits	1044	Target Neighborhood Hits	765	Shared Neighborhood Hits	609
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

BLK_MOUSE
θ value	1.17247e-07 (rank : 599)	NC score	0.739015 (rank : 630)
Query Neighborhood Hits	1044	Target Neighborhood Hits	992	Shared Neighborhood Hits	774
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ERN1_MOUSE
θ value	1.17247e-07 (rank : 600)	NC score	0.868236 (rank : 439)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	766
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

IRAK4_HUMAN
θ value	1.17247e-07 (rank : 601)	NC score	0.847898 (rank : 491)
Query Neighborhood Hits	1044	Target Neighborhood Hits	816	Shared Neighborhood Hits	755
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

JAK1_HUMAN
θ value	1.17247e-07 (rank : 602)	NC score	0.777125 (rank : 579)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	775
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

PTK6_MOUSE
θ value	1.17247e-07 (rank : 603)	NC score	0.770959 (rank : 586)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1026	Shared Neighborhood Hits	774
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

MK10_HUMAN
θ value	1.53129e-07 (rank : 604)	NC score	0.872927 (rank : 420)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	772
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
θ value	1.53129e-07 (rank : 605)	NC score	0.872664 (rank : 421)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	773
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

TOPK_HUMAN
θ value	1.53129e-07 (rank : 606)	NC score	0.669443 (rank : 753)
Query Neighborhood Hits	1044	Target Neighborhood Hits	605	Shared Neighborhood Hits	551
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

CSK22_MOUSE
θ value	1.99992e-07 (rank : 607)	NC score	0.863175 (rank : 447)
Query Neighborhood Hits	1044	Target Neighborhood Hits	758	Shared Neighborhood Hits	718
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

GRK4_HUMAN
θ value	1.99992e-07 (rank : 608)	NC score	0.878054 (rank : 395)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	764
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

MUSK_HUMAN
θ value	1.99992e-07 (rank : 609)	NC score	0.641947 (rank : 780)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1074	Shared Neighborhood Hits	736
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MK08_HUMAN
θ value	2.61198e-07 (rank : 610)	NC score	0.874367 (rank : 413)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	773
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	2.61198e-07 (rank : 611)	NC score	0.875073 (rank : 406)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	773
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MLTK_HUMAN
θ value	2.61198e-07 (rank : 612)	NC score	0.832836 (rank : 527)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	778
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	2.61198e-07 (rank : 613)	NC score	0.833386 (rank : 525)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	778
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_MOUSE
θ value	2.61198e-07 (rank : 614)	NC score	0.830414 (rank : 531)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	772
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

RON_HUMAN
θ value	2.61198e-07 (rank : 615)	NC score	0.713147 (rank : 683)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	753
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	2.61198e-07 (rank : 616)	NC score	0.701693 (rank : 706)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1018	Shared Neighborhood Hits	753
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROS_HUMAN
θ value	2.61198e-07 (rank : 617)	NC score	0.691247 (rank : 720)
Query Neighborhood Hits	1044	Target Neighborhood Hits	907	Shared Neighborhood Hits	722
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

JAK1_MOUSE
θ value	3.41135e-07 (rank : 618)	NC score	0.770220 (rank : 587)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	773
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

KC1A_HUMAN
θ value	3.41135e-07 (rank : 619)	NC score	0.727676 (rank : 643)
Query Neighborhood Hits	1044	Target Neighborhood Hits	728	Shared Neighborhood Hits	700
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	3.41135e-07 (rank : 620)	NC score	0.727676 (rank : 644)
Query Neighborhood Hits	1044	Target Neighborhood Hits	728	Shared Neighborhood Hits	700
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

M4K5_MOUSE
θ value	3.41135e-07 (rank : 621)	NC score	0.873342 (rank : 419)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	770
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

RIPK3_HUMAN
θ value	3.41135e-07 (rank : 622)	NC score	0.838336 (rank : 512)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	753
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

ROR1_MOUSE
θ value	3.41135e-07 (rank : 623)	NC score	0.703039 (rank : 703)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1025	Shared Neighborhood Hits	756
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

TGFR2_MOUSE
θ value	3.41135e-07 (rank : 624)	NC score	0.718035 (rank : 669)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	698
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

GSK3A_HUMAN
θ value	4.45536e-07 (rank : 625)	NC score	0.881302 (rank : 378)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	755
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

JAK3_HUMAN
θ value	4.45536e-07 (rank : 626)	NC score	0.787213 (rank : 572)
Query Neighborhood Hits	1044	Target Neighborhood Hits	827	Shared Neighborhood Hits	766
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

M4K5_HUMAN
θ value	4.45536e-07 (rank : 627)	NC score	0.871647 (rank : 427)
Query Neighborhood Hits	1044	Target Neighborhood Hits	845	Shared Neighborhood Hits	774
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

TGFR2_HUMAN
θ value	4.45536e-07 (rank : 628)	NC score	0.717361 (rank : 672)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	697
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

E2AK3_MOUSE
θ value	5.81887e-07 (rank : 629)	NC score	0.868764 (rank : 437)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	776
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

M3K8_HUMAN
θ value	5.81887e-07 (rank : 630)	NC score	0.885847 (rank : 340)
Query Neighborhood Hits	1044	Target Neighborhood Hits	807	Shared Neighborhood Hits	751
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

BMX_MOUSE
θ value	7.59969e-07 (rank : 631)	NC score	0.749011 (rank : 617)
Query Neighborhood Hits	1044	Target Neighborhood Hits	912	Shared Neighborhood Hits	743
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

BRAF1_HUMAN
θ value	7.59969e-07 (rank : 632)	NC score	0.837417 (rank : 513)
Query Neighborhood Hits	1044	Target Neighborhood Hits	883	Shared Neighborhood Hits	777
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

E2AK2_HUMAN
θ value	7.59969e-07 (rank : 633)	NC score	0.899796 (rank : 251)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	777
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK3_HUMAN
θ value	7.59969e-07 (rank : 634)	NC score	0.868336 (rank : 438)
Query Neighborhood Hits	1044	Target Neighborhood Hits	859	Shared Neighborhood Hits	772
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

JAK3_MOUSE
θ value	7.59969e-07 (rank : 635)	NC score	0.792259 (rank : 570)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	758
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

KC1AL_HUMAN
θ value	7.59969e-07 (rank : 636)	NC score	0.726818 (rank : 645)
Query Neighborhood Hits	1044	Target Neighborhood Hits	734	Shared Neighborhood Hits	704
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KSR2_HUMAN
θ value	7.59969e-07 (rank : 637)	NC score	0.813003 (rank : 545)
Query Neighborhood Hits	1044	Target Neighborhood Hits	920	Shared Neighborhood Hits	757
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

SRPK1_HUMAN
θ value	7.59969e-07 (rank : 638)	NC score	0.616661 (rank : 801)
Query Neighborhood Hits	1044	Target Neighborhood Hits	706	Shared Neighborhood Hits	577
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

CLK2_HUMAN
θ value	9.92553e-07 (rank : 639)	NC score	0.810726 (rank : 550)
Query Neighborhood Hits	1044	Target Neighborhood Hits	752	Shared Neighborhood Hits	705
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

E2AK4_MOUSE
θ value	9.92553e-07 (rank : 640)	NC score	0.856268 (rank : 474)
Query Neighborhood Hits	1044	Target Neighborhood Hits	984	Shared Neighborhood Hits	805
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

CLK3_HUMAN
θ value	1.29631e-06 (rank : 641)	NC score	0.794667 (rank : 568)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	703
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	1.29631e-06 (rank : 642)	NC score	0.793908 (rank : 569)
Query Neighborhood Hits	1044	Target Neighborhood Hits	761	Shared Neighborhood Hits	703
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

E2AK4_HUMAN
θ value	1.29631e-06 (rank : 643)	NC score	0.860579 (rank : 454)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1012	Shared Neighborhood Hits	817
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

SRPK1_MOUSE
θ value	1.29631e-06 (rank : 644)	NC score	0.620146 (rank : 798)
Query Neighborhood Hits	1044	Target Neighborhood Hits	639	Shared Neighborhood Hits	565
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

CLK1_HUMAN
θ value	1.69304e-06 (rank : 645)	NC score	0.817251 (rank : 539)
Query Neighborhood Hits	1044	Target Neighborhood Hits	756	Shared Neighborhood Hits	707
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

EPHAA_HUMAN
θ value	1.69304e-06 (rank : 646)	NC score	0.610952 (rank : 807)
Query Neighborhood Hits	1044	Target Neighborhood Hits	960	Shared Neighborhood Hits	684
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

STK16_MOUSE
θ value	1.69304e-06 (rank : 647)	NC score	0.888917 (rank : 318)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	765
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

CLK1_MOUSE
θ value	2.21117e-06 (rank : 648)	NC score	0.817592 (rank : 538)
Query Neighborhood Hits	1044	Target Neighborhood Hits	760	Shared Neighborhood Hits	715
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

IRAK1_MOUSE
θ value	2.21117e-06 (rank : 649)	NC score	0.768372 (rank : 591)
Query Neighborhood Hits	1044	Target Neighborhood Hits	784	Shared Neighborhood Hits	700
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

MOS_HUMAN
θ value	2.21117e-06 (rank : 650)	NC score	0.831868 (rank : 528)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	773
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ALK_MOUSE
θ value	2.88788e-06 (rank : 651)	NC score	0.650377 (rank : 776)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	700
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

IRAK1_HUMAN
θ value	2.88788e-06 (rank : 652)	NC score	0.769171 (rank : 588)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	702
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

LRRK2_HUMAN
θ value	2.88788e-06 (rank : 653)	NC score	0.745381 (rank : 624)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1382	Shared Neighborhood Hits	775
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

TRIB2_HUMAN
θ value	2.88788e-06 (rank : 654)	NC score	0.810916 (rank : 549)
Query Neighborhood Hits	1044	Target Neighborhood Hits	657	Shared Neighborhood Hits	622
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	2.88788e-06 (rank : 655)	NC score	0.810386 (rank : 551)
Query Neighborhood Hits	1044	Target Neighborhood Hits	653	Shared Neighborhood Hits	618
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TOPK_MOUSE
θ value	3.77169e-06 (rank : 656)	NC score	0.673699 (rank : 746)
Query Neighborhood Hits	1044	Target Neighborhood Hits	618	Shared Neighborhood Hits	562
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

TRIB1_MOUSE
θ value	3.77169e-06 (rank : 657)	NC score	0.780781 (rank : 575)
Query Neighborhood Hits	1044	Target Neighborhood Hits	593	Shared Neighborhood Hits	569
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

ALK_HUMAN
θ value	4.92598e-06 (rank : 658)	NC score	0.652453 (rank : 773)
Query Neighborhood Hits	1044	Target Neighborhood Hits	795	Shared Neighborhood Hits	695
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

CLK4_HUMAN
θ value	4.92598e-06 (rank : 659)	NC score	0.813948 (rank : 544)
Query Neighborhood Hits	1044	Target Neighborhood Hits	759	Shared Neighborhood Hits	717
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

NRK_HUMAN
θ value	4.92598e-06 (rank : 660)	NC score	0.858934 (rank : 464)
Query Neighborhood Hits	1044	Target Neighborhood Hits	931	Shared Neighborhood Hits	783
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

NRK_MOUSE
θ value	4.92598e-06 (rank : 661)	NC score	0.856995 (rank : 473)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	781
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

STK16_HUMAN
θ value	4.92598e-06 (rank : 662)	NC score	0.889258 (rank : 317)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	767
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

CLK4_MOUSE
θ value	6.43352e-06 (rank : 663)	NC score	0.812533 (rank : 546)
Query Neighborhood Hits	1044	Target Neighborhood Hits	759	Shared Neighborhood Hits	715
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

PRP4B_HUMAN
θ value	6.43352e-06 (rank : 664)	NC score	0.830432 (rank : 530)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1030	Shared Neighborhood Hits	763
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	6.43352e-06 (rank : 665)	NC score	0.829844 (rank : 532)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1040	Shared Neighborhood Hits	773
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

ROR2_HUMAN
θ value	6.43352e-06 (rank : 666)	NC score	0.681683 (rank : 732)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1014	Shared Neighborhood Hits	739
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

UHMK1_HUMAN
θ value	6.43352e-06 (rank : 667)	NC score	0.832992 (rank : 526)
Query Neighborhood Hits	1044	Target Neighborhood Hits	808	Shared Neighborhood Hits	727
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

WEE1_MOUSE
θ value	6.43352e-06 (rank : 668)	NC score	0.841530 (rank : 506)
Query Neighborhood Hits	1044	Target Neighborhood Hits	794	Shared Neighborhood Hits	720
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

M4K4_HUMAN
θ value	8.40245e-06 (rank : 669)	NC score	0.858317 (rank : 467)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1589	Shared Neighborhood Hits	926
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

RON_MOUSE
θ value	8.40245e-06 (rank : 670)	NC score	0.701188 (rank : 707)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	746
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

CI096_HUMAN
θ value	1.09739e-05 (rank : 671)	NC score	0.870283 (rank : 431)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	750
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

CLK2_MOUSE
θ value	1.09739e-05 (rank : 672)	NC score	0.797664 (rank : 566)
Query Neighborhood Hits	1044	Target Neighborhood Hits	743	Shared Neighborhood Hits	700
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

NTRK3_HUMAN
θ value	1.09739e-05 (rank : 673)	NC score	0.687232 (rank : 725)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1115	Shared Neighborhood Hits	745
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

TRIB1_HUMAN
θ value	1.09739e-05 (rank : 674)	NC score	0.781358 (rank : 574)
Query Neighborhood Hits	1044	Target Neighborhood Hits	598	Shared Neighborhood Hits	565
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

UHMK1_MOUSE
θ value	1.09739e-05 (rank : 675)	NC score	0.831752 (rank : 529)
Query Neighborhood Hits	1044	Target Neighborhood Hits	809	Shared Neighborhood Hits	727
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

NRBP_HUMAN
θ value	1.43324e-05 (rank : 676)	NC score	0.535833 (rank : 818)
Query Neighborhood Hits	1044	Target Neighborhood Hits	448	Shared Neighborhood Hits	402
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

WEE1B_HUMAN
θ value	1.87187e-05 (rank : 677)	NC score	0.814352 (rank : 542)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	698
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

WEE1_HUMAN
θ value	1.87187e-05 (rank : 678)	NC score	0.826372 (rank : 534)
Query Neighborhood Hits	1044	Target Neighborhood Hits	777	Shared Neighborhood Hits	699
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

KSR1_MOUSE
θ value	2.44474e-05 (rank : 679)	NC score	0.781493 (rank : 573)
Query Neighborhood Hits	1044	Target Neighborhood Hits	870	Shared Neighborhood Hits	749
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

M3K14_HUMAN
θ value	2.44474e-05 (rank : 680)	NC score	0.891915 (rank : 310)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	764
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

NRBP_MOUSE
θ value	2.44474e-05 (rank : 681)	NC score	0.534134 (rank : 819)
Query Neighborhood Hits	1044	Target Neighborhood Hits	442	Shared Neighborhood Hits	401
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

MLKL_HUMAN
θ value	3.19293e-05 (rank : 682)	NC score	0.621516 (rank : 797)
Query Neighborhood Hits	1044	Target Neighborhood Hits	600	Shared Neighborhood Hits	541
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

TESK2_MOUSE
θ value	3.19293e-05 (rank : 683)	NC score	0.836022 (rank : 519)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	763
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

LIMK1_MOUSE
θ value	4.1701e-05 (rank : 684)	NC score	0.808139 (rank : 554)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1008	Shared Neighborhood Hits	771
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

MYH2_HUMAN
θ value	4.1701e-05 (rank : 685)	NC score	0.089066 (rank : 883)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1491	Shared Neighborhood Hits	243
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

TESK2_HUMAN
θ value	4.1701e-05 (rank : 686)	NC score	0.835808 (rank : 520)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	765
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

VGFR1_HUMAN
θ value	4.1701e-05 (rank : 687)	NC score	0.627662 (rank : 789)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1109	Shared Neighborhood Hits	750
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

BMPR2_MOUSE
θ value	5.44631e-05 (rank : 688)	NC score	0.671608 (rank : 749)
Query Neighborhood Hits	1044	Target Neighborhood Hits	738	Shared Neighborhood Hits	664
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

MYH1_MOUSE
θ value	5.44631e-05 (rank : 689)	NC score	0.089733 (rank : 881)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1461	Shared Neighborhood Hits	249
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

ROR2_MOUSE
θ value	5.44631e-05 (rank : 690)	NC score	0.655053 (rank : 770)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1000	Shared Neighborhood Hits	721
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

MATK_MOUSE
θ value	7.1131e-05 (rank : 691)	NC score	0.748741 (rank : 618)
Query Neighborhood Hits	1044	Target Neighborhood Hits	952	Shared Neighborhood Hits	767
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

KSR1_HUMAN
θ value	0.000121331 (rank : 692)	NC score	0.766551 (rank : 593)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	738
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

MYH1_HUMAN
θ value	0.000121331 (rank : 693)	NC score	0.089290 (rank : 882)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1478	Shared Neighborhood Hits	244
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MY18A_MOUSE
θ value	0.000158464 (rank : 694)	NC score	0.095691 (rank : 862)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1989	Shared Neighborhood Hits	294
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

TIE1_HUMAN
θ value	0.000158464 (rank : 695)	NC score	0.678614 (rank : 735)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1241	Shared Neighborhood Hits	756
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	0.000158464 (rank : 696)	NC score	0.680820 (rank : 733)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1266	Shared Neighborhood Hits	758
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

F5006_HUMAN
θ value	0.00020696 (rank : 697)	NC score	0.873759 (rank : 417)
Query Neighborhood Hits	1044	Target Neighborhood Hits	794	Shared Neighborhood Hits	739
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

KC1D_HUMAN
θ value	0.00020696 (rank : 698)	NC score	0.709994 (rank : 687)
Query Neighborhood Hits	1044	Target Neighborhood Hits	737	Shared Neighborhood Hits	692
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	0.00020696 (rank : 699)	NC score	0.709982 (rank : 688)
Query Neighborhood Hits	1044	Target Neighborhood Hits	737	Shared Neighborhood Hits	692
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

LIMK1_HUMAN
θ value	0.00020696 (rank : 700)	NC score	0.808621 (rank : 552)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1005	Shared Neighborhood Hits	771
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

M4K4_MOUSE
θ value	0.00020696 (rank : 701)	NC score	0.850736 (rank : 486)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1560	Shared Neighborhood Hits	921
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

WEE1B_MOUSE
θ value	0.00020696 (rank : 702)	NC score	0.812340 (rank : 547)
Query Neighborhood Hits	1044	Target Neighborhood Hits	765	Shared Neighborhood Hits	699
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

BMPR2_HUMAN
θ value	0.000270298 (rank : 703)	NC score	0.670949 (rank : 750)
Query Neighborhood Hits	1044	Target Neighborhood Hits	736	Shared Neighborhood Hits	664
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

MATK_HUMAN
θ value	0.000270298 (rank : 704)	NC score	0.743462 (rank : 626)
Query Neighborhood Hits	1044	Target Neighborhood Hits	954	Shared Neighborhood Hits	766
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MYH11_HUMAN
θ value	0.000270298 (rank : 705)	NC score	0.086684 (rank : 897)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1806	Shared Neighborhood Hits	260
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

LTK_HUMAN
θ value	0.00035302 (rank : 706)	NC score	0.642967 (rank : 779)
Query Neighborhood Hits	1044	Target Neighborhood Hits	774	Shared Neighborhood Hits	703
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

MYH4_MOUSE
θ value	0.00035302 (rank : 707)	NC score	0.087274 (rank : 893)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1476	Shared Neighborhood Hits	244
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

VGFR1_MOUSE
θ value	0.00035302 (rank : 708)	NC score	0.633690 (rank : 783)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1118	Shared Neighborhood Hits	753
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

F5006_MOUSE
θ value	0.000461057 (rank : 709)	NC score	0.881947 (rank : 371)
Query Neighborhood Hits	1044	Target Neighborhood Hits	793	Shared Neighborhood Hits	746
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

TGFR1_HUMAN
θ value	0.000461057 (rank : 710)	NC score	0.678560 (rank : 736)
Query Neighborhood Hits	1044	Target Neighborhood Hits	755	Shared Neighborhood Hits	705
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	0.000461057 (rank : 711)	NC score	0.678348 (rank : 737)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	705
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

ACV1C_HUMAN
θ value	0.000602161 (rank : 712)	NC score	0.617149 (rank : 799)
Query Neighborhood Hits	1044	Target Neighborhood Hits	709	Shared Neighborhood Hits	653
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ACV1C_MOUSE
θ value	0.000602161 (rank : 713)	NC score	0.621966 (rank : 796)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	659
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

M3K14_MOUSE
θ value	0.000602161 (rank : 714)	NC score	0.886108 (rank : 338)
Query Neighborhood Hits	1044	Target Neighborhood Hits	889	Shared Neighborhood Hits	754
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

KC1G2_HUMAN
θ value	0.000786445 (rank : 715)	NC score	0.661226 (rank : 763)
Query Neighborhood Hits	1044	Target Neighborhood Hits	693	Shared Neighborhood Hits	662
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G2_MOUSE
θ value	0.000786445 (rank : 716)	NC score	0.663456 (rank : 761)
Query Neighborhood Hits	1044	Target Neighborhood Hits	695	Shared Neighborhood Hits	663
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G3_HUMAN
θ value	0.000786445 (rank : 717)	NC score	0.685351 (rank : 729)
Query Neighborhood Hits	1044	Target Neighborhood Hits	711	Shared Neighborhood Hits	678
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

MYH4_HUMAN
θ value	0.000786445 (rank : 718)	NC score	0.086926 (rank : 895)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1377	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

AVR2A_HUMAN
θ value	0.00102713 (rank : 719)	NC score	0.712980 (rank : 685)
Query Neighborhood Hits	1044	Target Neighborhood Hits	767	Shared Neighborhood Hits	717
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	0.00102713 (rank : 720)	NC score	0.712990 (rank : 684)
Query Neighborhood Hits	1044	Target Neighborhood Hits	767	Shared Neighborhood Hits	717
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

CROCC_MOUSE
θ value	0.00102713 (rank : 721)	NC score	0.086544 (rank : 898)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1460	Shared Neighborhood Hits	244
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

FGFR2_HUMAN
θ value	0.00102713 (rank : 722)	NC score	0.700938 (rank : 708)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1062	Shared Neighborhood Hits	762
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	0.00102713 (rank : 723)	NC score	0.702996 (rank : 704)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1062	Shared Neighborhood Hits	762
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

LTK_MOUSE
θ value	0.00102713 (rank : 724)	NC score	0.649245 (rank : 777)
Query Neighborhood Hits	1044	Target Neighborhood Hits	770	Shared Neighborhood Hits	696
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

MYH8_HUMAN
θ value	0.00102713 (rank : 725)	NC score	0.088483 (rank : 885)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1610	Shared Neighborhood Hits	255
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
θ value	0.00102713 (rank : 726)	NC score	0.087010 (rank : 894)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1600	Shared Neighborhood Hits	252
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

UFO_HUMAN
θ value	0.00102713 (rank : 727)	NC score	0.666202 (rank : 758)
Query Neighborhood Hits	1044	Target Neighborhood Hits	981	Shared Neighborhood Hits	713
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	0.00102713 (rank : 728)	NC score	0.670267 (rank : 751)
Query Neighborhood Hits	1044	Target Neighborhood Hits	988	Shared Neighborhood Hits	714
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

CP250_MOUSE
θ value	0.00134147 (rank : 729)	NC score	0.082863 (rank : 924)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1583	Shared Neighborhood Hits	247
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

REST_HUMAN
θ value	0.00134147 (rank : 730)	NC score	0.081052 (rank : 955)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1605	Shared Neighborhood Hits	258
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

E2AK1_MOUSE
θ value	0.00175202 (rank : 731)	NC score	0.866431 (rank : 443)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	767
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

MLKL_MOUSE
θ value	0.00175202 (rank : 732)	NC score	0.706343 (rank : 695)
Query Neighborhood Hits	1044	Target Neighborhood Hits	707	Shared Neighborhood Hits	651
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

PINK1_MOUSE
θ value	0.00175202 (rank : 733)	NC score	0.765410 (rank : 594)
Query Neighborhood Hits	1044	Target Neighborhood Hits	726	Shared Neighborhood Hits	676
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

BPAEA_MOUSE
θ value	0.00228821 (rank : 734)	NC score	0.078602 (rank : 993)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1480	Shared Neighborhood Hits	254
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CROCC_HUMAN
θ value	0.00228821 (rank : 735)	NC score	0.084295 (rank : 915)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1409	Shared Neighborhood Hits	248
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

E2AK1_HUMAN
θ value	0.00228821 (rank : 736)	NC score	0.862664 (rank : 448)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	772
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

SYCP1_MOUSE
θ value	0.00228821 (rank : 737)	NC score	0.078785 (rank : 987)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1456	Shared Neighborhood Hits	244
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TRHY_HUMAN
θ value	0.00228821 (rank : 738)	NC score	0.092287 (rank : 873)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1385	Shared Neighborhood Hits	223
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

ACVR1_HUMAN
θ value	0.00298849 (rank : 739)	NC score	0.694415 (rank : 717)
Query Neighborhood Hits	1044	Target Neighborhood Hits	760	Shared Neighborhood Hits	714
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

BMR1B_HUMAN
θ value	0.00298849 (rank : 740)	NC score	0.675968 (rank : 740)
Query Neighborhood Hits	1044	Target Neighborhood Hits	760	Shared Neighborhood Hits	706
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	0.00298849 (rank : 741)	NC score	0.676682 (rank : 739)
Query Neighborhood Hits	1044	Target Neighborhood Hits	758	Shared Neighborhood Hits	706
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

CSK_MOUSE
θ value	0.00298849 (rank : 742)	NC score	0.756591 (rank : 602)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	773
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

LRRK2_MOUSE
θ value	0.00298849 (rank : 743)	NC score	0.725345 (rank : 647)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1359	Shared Neighborhood Hits	771
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

MYH10_MOUSE
θ value	0.00298849 (rank : 744)	NC score	0.083194 (rank : 922)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1612	Shared Neighborhood Hits	250
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH11_MOUSE
θ value	0.00298849 (rank : 745)	NC score	0.085955 (rank : 903)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1777	Shared Neighborhood Hits	255
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH14_MOUSE
θ value	0.00298849 (rank : 746)	NC score	0.087291 (rank : 892)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1225	Shared Neighborhood Hits	227
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

KC1E_HUMAN
θ value	0.00390308 (rank : 747)	NC score	0.703481 (rank : 701)
Query Neighborhood Hits	1044	Target Neighborhood Hits	732	Shared Neighborhood Hits	694
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	0.00390308 (rank : 748)	NC score	0.703474 (rank : 702)
Query Neighborhood Hits	1044	Target Neighborhood Hits	728	Shared Neighborhood Hits	694
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

MYH7_HUMAN
θ value	0.00390308 (rank : 749)	NC score	0.087823 (rank : 888)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1559	Shared Neighborhood Hits	252
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

UBXD2_HUMAN
θ value	0.00390308 (rank : 750)	NC score	0.057690 (rank : 1246)
Query Neighborhood Hits	1044	Target Neighborhood Hits	241	Shared Neighborhood Hits	83
SwissProt Accessions	Q92575, Q8IYM5	Gene names	UBXD2, KIAA0242, UBXDC1
Domain Architecture
Description	UBX domain-containing protein 2.

ANPRB_HUMAN
θ value	0.00509761 (rank : 751)	NC score	0.506890 (rank : 823)
Query Neighborhood Hits	1044	Target Neighborhood Hits	646	Shared Neighborhood Hits	541
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

CSK_HUMAN
θ value	0.00509761 (rank : 752)	NC score	0.748704 (rank : 619)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	772
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

FGFR1_HUMAN
θ value	0.00509761 (rank : 753)	NC score	0.697335 (rank : 712)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1069	Shared Neighborhood Hits	765
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	0.00509761 (rank : 754)	NC score	0.697442 (rank : 711)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1068	Shared Neighborhood Hits	765
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

RIPK5_HUMAN
θ value	0.00509761 (rank : 755)	NC score	0.837383 (rank : 514)
Query Neighborhood Hits	1044	Target Neighborhood Hits	864	Shared Neighborhood Hits	783
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	0.00509761 (rank : 756)	NC score	0.837176 (rank : 517)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	785
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

ANPRA_HUMAN
θ value	0.00665767 (rank : 757)	NC score	0.474718 (rank : 832)
Query Neighborhood Hits	1044	Target Neighborhood Hits	612	Shared Neighborhood Hits	504
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

GUC2C_HUMAN
θ value	0.00665767 (rank : 758)	NC score	0.513814 (rank : 820)
Query Neighborhood Hits	1044	Target Neighborhood Hits	624	Shared Neighborhood Hits	541
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

PLEC1_HUMAN
θ value	0.00665767 (rank : 759)	NC score	0.065453 (rank : 1127)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1326	Shared Neighborhood Hits	215
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

TXLNB_HUMAN
θ value	0.00665767 (rank : 760)	NC score	0.071580 (rank : 1072)
Query Neighborhood Hits	1044	Target Neighborhood Hits	912	Shared Neighborhood Hits	184
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

MYH9_HUMAN
θ value	0.00869519 (rank : 761)	NC score	0.084503 (rank : 913)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1762	Shared Neighborhood Hits	260
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

TESK1_MOUSE
θ value	0.00869519 (rank : 762)	NC score	0.835667 (rank : 522)
Query Neighborhood Hits	1044	Target Neighborhood Hits	862	Shared Neighborhood Hits	753
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

AKAP9_HUMAN
θ value	0.0113563 (rank : 763)	NC score	0.081499 (rank : 947)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1710	Shared Neighborhood Hits	265
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

GOGA5_HUMAN
θ value	0.0113563 (rank : 764)	NC score	0.085293 (rank : 909)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1168	Shared Neighborhood Hits	232
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

IGF1R_MOUSE
θ value	0.0113563 (rank : 765)	NC score	0.659538 (rank : 764)
Query Neighborhood Hits	1044	Target Neighborhood Hits	973	Shared Neighborhood Hits	741
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

MYH10_HUMAN
θ value	0.0113563 (rank : 766)	NC score	0.083177 (rank : 923)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1620	Shared Neighborhood Hits	250
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

SAFB2_HUMAN
θ value	0.0113563 (rank : 767)	NC score	0.057368 (rank : 1253)
Query Neighborhood Hits	1044	Target Neighborhood Hits	720	Shared Neighborhood Hits	163
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

SFR12_HUMAN
θ value	0.0113563 (rank : 768)	NC score	0.057897 (rank : 1244)
Query Neighborhood Hits	1044	Target Neighborhood Hits	553	Shared Neighborhood Hits	122
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

XE7_HUMAN
θ value	0.0113563 (rank : 769)	NC score	0.091550 (rank : 876)
Query Neighborhood Hits	1044	Target Neighborhood Hits	738	Shared Neighborhood Hits	176
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

CCD27_HUMAN
θ value	0.0148317 (rank : 770)	NC score	0.073829 (rank : 1043)
Query Neighborhood Hits	1044	Target Neighborhood Hits	594	Shared Neighborhood Hits	170
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

ITSN1_HUMAN
θ value	0.0148317 (rank : 771)	NC score	0.085612 (rank : 907)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1757	Shared Neighborhood Hits	294
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

KC1G1_HUMAN
θ value	0.0148317 (rank : 772)	NC score	0.686524 (rank : 726)
Query Neighborhood Hits	1044	Target Neighborhood Hits	708	Shared Neighborhood Hits	675
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	0.0148317 (rank : 773)	NC score	0.688209 (rank : 724)
Query Neighborhood Hits	1044	Target Neighborhood Hits	713	Shared Neighborhood Hits	677
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

MYH6_MOUSE
θ value	0.0148317 (rank : 774)	NC score	0.087585 (rank : 890)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1501	Shared Neighborhood Hits	252
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

SMC4_MOUSE
θ value	0.0148317 (rank : 775)	NC score	0.063394 (rank : 1154)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	188
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

TESK1_HUMAN
θ value	0.0148317 (rank : 776)	NC score	0.833885 (rank : 524)
Query Neighborhood Hits	1044	Target Neighborhood Hits	864	Shared Neighborhood Hits	750
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

CING_HUMAN
θ value	0.0193708 (rank : 777)	NC score	0.093407 (rank : 869)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1275	Shared Neighborhood Hits	244
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

FLT3_HUMAN
θ value	0.0193708 (rank : 778)	NC score	0.628245 (rank : 788)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	740
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

MY18A_HUMAN
θ value	0.0193708 (rank : 779)	NC score	0.094881 (rank : 866)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1929	Shared Neighborhood Hits	283
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

VRK2_MOUSE
θ value	0.0193708 (rank : 780)	NC score	0.512611 (rank : 821)
Query Neighborhood Hits	1044	Target Neighborhood Hits	586	Shared Neighborhood Hits	559
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

ACVR1_MOUSE
θ value	0.0252991 (rank : 781)	NC score	0.698703 (rank : 710)
Query Neighborhood Hits	1044	Target Neighborhood Hits	768	Shared Neighborhood Hits	720
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ANPRB_MOUSE
θ value	0.0252991 (rank : 782)	NC score	0.478533 (rank : 830)
Query Neighborhood Hits	1044	Target Neighborhood Hits	607	Shared Neighborhood Hits	516
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

CING_MOUSE
θ value	0.0252991 (rank : 783)	NC score	0.093408 (rank : 868)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1432	Shared Neighborhood Hits	250
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

GOGA4_MOUSE
θ value	0.0252991 (rank : 784)	NC score	0.082167 (rank : 930)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1939	Shared Neighborhood Hits	280
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

GOGA5_MOUSE
θ value	0.0252991 (rank : 785)	NC score	0.082551 (rank : 927)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1434	Shared Neighborhood Hits	247
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

MYH6_HUMAN
θ value	0.0252991 (rank : 786)	NC score	0.086106 (rank : 902)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1426	Shared Neighborhood Hits	244
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

PINK1_HUMAN
θ value	0.0252991 (rank : 787)	NC score	0.755865 (rank : 603)
Query Neighborhood Hits	1044	Target Neighborhood Hits	741	Shared Neighborhood Hits	675
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

RB6I2_MOUSE
θ value	0.0252991 (rank : 788)	NC score	0.085253 (rank : 910)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1433	Shared Neighborhood Hits	249
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

REN3B_HUMAN
θ value	0.0252991 (rank : 789)	NC score	0.070885 (rank : 1081)
Query Neighborhood Hits	1044	Target Neighborhood Hits	412	Shared Neighborhood Hits	114
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

TTBK2_HUMAN
θ value	0.0252991 (rank : 790)	NC score	0.724143 (rank : 650)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	675
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

NFL_MOUSE
θ value	0.0330416 (rank : 791)	NC score	0.023510 (rank : 1387)
Query Neighborhood Hits	1044	Target Neighborhood Hits	695	Shared Neighborhood Hits	163
SwissProt Accessions	P08551, Q8K0Z0	Gene names	Nefl, Nf68, Nfl
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

TTBK2_MOUSE
θ value	0.0330416 (rank : 792)	NC score	0.721452 (rank : 660)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	677
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

CALD1_HUMAN
θ value	0.0431538 (rank : 793)	NC score	0.084311 (rank : 914)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	195
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CENPE_HUMAN
θ value	0.0431538 (rank : 794)	NC score	0.073526 (rank : 1049)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2060	Shared Neighborhood Hits	284
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

FGFR3_HUMAN
θ value	0.0431538 (rank : 795)	NC score	0.689462 (rank : 723)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1042	Shared Neighborhood Hits	762
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	0.0431538 (rank : 796)	NC score	0.685299 (rank : 730)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1059	Shared Neighborhood Hits	760
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FLT3_MOUSE
θ value	0.0431538 (rank : 797)	NC score	0.624371 (rank : 793)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	738
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

GRAP1_HUMAN
θ value	0.0431538 (rank : 798)	NC score	0.085132 (rank : 911)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	214
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

IGF1R_HUMAN
θ value	0.0431538 (rank : 799)	NC score	0.657076 (rank : 766)
Query Neighborhood Hits	1044	Target Neighborhood Hits	977	Shared Neighborhood Hits	740
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ANPRA_MOUSE
θ value	0.0563607 (rank : 800)	NC score	0.475142 (rank : 831)
Query Neighborhood Hits	1044	Target Neighborhood Hits	600	Shared Neighborhood Hits	502
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ERC2_HUMAN
θ value	0.0563607 (rank : 801)	NC score	0.077226 (rank : 1004)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1156	Shared Neighborhood Hits	220
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

SMC3_HUMAN
θ value	0.0563607 (rank : 802)	NC score	0.078630 (rank : 992)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1186	Shared Neighborhood Hits	232
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	0.0563607 (rank : 803)	NC score	0.078782 (rank : 988)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1187	Shared Neighborhood Hits	232
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

BMR1A_HUMAN
θ value	0.0736092 (rank : 804)	NC score	0.685964 (rank : 727)
Query Neighborhood Hits	1044	Target Neighborhood Hits	759	Shared Neighborhood Hits	706
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	0.0736092 (rank : 805)	NC score	0.684742 (rank : 731)
Query Neighborhood Hits	1044	Target Neighborhood Hits	758	Shared Neighborhood Hits	706
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

BUB1_HUMAN
θ value	0.0736092 (rank : 806)	NC score	0.430790 (rank : 837)
Query Neighborhood Hits	1044	Target Neighborhood Hits	543	Shared Neighborhood Hits	412
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

CT2NL_HUMAN
θ value	0.0736092 (rank : 807)	NC score	0.081505 (rank : 946)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1059	Shared Neighborhood Hits	223
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

NIN_MOUSE
θ value	0.0736092 (rank : 808)	NC score	0.081433 (rank : 948)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1376	Shared Neighborhood Hits	236
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

SWP70_MOUSE
θ value	0.0736092 (rank : 809)	NC score	0.085414 (rank : 908)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1097	Shared Neighborhood Hits	235
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

UBXD2_MOUSE
θ value	0.0736092 (rank : 810)	NC score	0.042917 (rank : 1363)
Query Neighborhood Hits	1044	Target Neighborhood Hits	183	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VCH8, Q8BW17	Gene names	Ubxd2, Ubxdc1
Domain Architecture
Description	UBX domain-containing protein 2.

BRE1A_MOUSE
θ value	0.0961366 (rank : 811)	NC score	0.075289 (rank : 1032)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1025	Shared Neighborhood Hits	194
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CCD19_HUMAN
θ value	0.0961366 (rank : 812)	NC score	0.098187 (rank : 859)
Query Neighborhood Hits	1044	Target Neighborhood Hits	639	Shared Neighborhood Hits	180
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CE290_HUMAN
θ value	0.0961366 (rank : 813)	NC score	0.082162 (rank : 931)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1553	Shared Neighborhood Hits	245
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

ENAH_HUMAN
θ value	0.0961366 (rank : 814)	NC score	0.066902 (rank : 1115)
Query Neighborhood Hits	1044	Target Neighborhood Hits	784	Shared Neighborhood Hits	175
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

ITSN2_HUMAN
θ value	0.0961366 (rank : 815)	NC score	0.081653 (rank : 943)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1173	Shared Neighborhood Hits	232
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	0.0961366 (rank : 816)	NC score	0.083434 (rank : 920)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1371	Shared Neighborhood Hits	270
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MYH13_HUMAN
θ value	0.0961366 (rank : 817)	NC score	0.085860 (rank : 904)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1504	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

TTBK1_HUMAN
θ value	0.0961366 (rank : 818)	NC score	0.727950 (rank : 641)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1058	Shared Neighborhood Hits	683
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

KIT_MOUSE
θ value	0.125558 (rank : 819)	NC score	0.624079 (rank : 794)
Query Neighborhood Hits	1044	Target Neighborhood Hits	949	Shared Neighborhood Hits	744
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

MOES_HUMAN
θ value	0.125558 (rank : 820)	NC score	0.048361 (rank : 1356)
Query Neighborhood Hits	1044	Target Neighborhood Hits	892	Shared Neighborhood Hits	193
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

NFL_HUMAN
θ value	0.125558 (rank : 821)	NC score	0.022888 (rank : 1388)
Query Neighborhood Hits	1044	Target Neighborhood Hits	666	Shared Neighborhood Hits	158
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

SFR12_MOUSE
θ value	0.125558 (rank : 822)	NC score	0.040628 (rank : 1366)
Query Neighborhood Hits	1044	Target Neighborhood Hits	486	Shared Neighborhood Hits	92
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

BPAEA_HUMAN
θ value	0.163984 (rank : 823)	NC score	0.060518 (rank : 1197)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1369	Shared Neighborhood Hits	223
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BRE1B_HUMAN
θ value	0.163984 (rank : 824)	NC score	0.080279 (rank : 965)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1040	Shared Neighborhood Hits	213
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

CSF1R_HUMAN
θ value	0.163984 (rank : 825)	NC score	0.596058 (rank : 810)
Query Neighborhood Hits	1044	Target Neighborhood Hits	943	Shared Neighborhood Hits	740
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

EPHB6_MOUSE
θ value	0.163984 (rank : 826)	NC score	0.598868 (rank : 809)
Query Neighborhood Hits	1044	Target Neighborhood Hits	906	Shared Neighborhood Hits	657
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERC2_MOUSE
θ value	0.163984 (rank : 827)	NC score	0.079886 (rank : 967)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1166	Shared Neighborhood Hits	224
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

GRAP1_MOUSE
θ value	0.163984 (rank : 828)	NC score	0.087414 (rank : 891)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1234	Shared Neighborhood Hits	241
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

RUFY1_HUMAN
θ value	0.163984 (rank : 829)	NC score	0.062314 (rank : 1172)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	203
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

TRIB3_MOUSE
θ value	0.163984 (rank : 830)	NC score	0.755589 (rank : 604)
Query Neighborhood Hits	1044	Target Neighborhood Hits	578	Shared Neighborhood Hits	555
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TRIPB_HUMAN
θ value	0.163984 (rank : 831)	NC score	0.079615 (rank : 972)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1587	Shared Neighborhood Hits	260
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

TYRO3_HUMAN
θ value	0.163984 (rank : 832)	NC score	0.663826 (rank : 760)
Query Neighborhood Hits	1044	Target Neighborhood Hits	995	Shared Neighborhood Hits	726
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

UACA_MOUSE
θ value	0.163984 (rank : 833)	NC score	0.076395 (rank : 1016)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1620	Shared Neighborhood Hits	249
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

CJ078_MOUSE
θ value	0.21417 (rank : 834)	NC score	0.011568 (rank : 1414)
Query Neighborhood Hits	1044	Target Neighborhood Hits	559	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

MYH9_MOUSE
θ value	0.21417 (rank : 835)	NC score	0.083197 (rank : 921)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1829	Shared Neighborhood Hits	263
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RAI14_HUMAN
θ value	0.21417 (rank : 836)	NC score	0.057963 (rank : 1243)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1367	Shared Neighborhood Hits	227
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

RB6I2_HUMAN
θ value	0.21417 (rank : 837)	NC score	0.085629 (rank : 906)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1584	Shared Neighborhood Hits	262
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RBP1_HUMAN
θ value	0.21417 (rank : 838)	NC score	0.030299 (rank : 1383)
Query Neighborhood Hits	1044	Target Neighborhood Hits	521	Shared Neighborhood Hits	132
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

SMCA4_HUMAN
θ value	0.21417 (rank : 839)	NC score	0.019309 (rank : 1393)
Query Neighborhood Hits	1044	Target Neighborhood Hits	597	Shared Neighborhood Hits	107
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

SNX23_HUMAN
θ value	0.21417 (rank : 840)	NC score	0.053681 (rank : 1312)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	200
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

ACV1B_HUMAN
θ value	0.279714 (rank : 841)	NC score	0.674850 (rank : 743)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	709
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	0.279714 (rank : 842)	NC score	0.675035 (rank : 742)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	709
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

CF060_HUMAN
θ value	0.279714 (rank : 843)	NC score	0.086538 (rank : 899)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1270	Shared Neighborhood Hits	247
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

EPHB6_HUMAN
θ value	0.279714 (rank : 844)	NC score	0.578705 (rank : 814)
Query Neighborhood Hits	1044	Target Neighborhood Hits	912	Shared Neighborhood Hits	629
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EVPL_HUMAN
θ value	0.279714 (rank : 845)	NC score	0.072297 (rank : 1063)
Query Neighborhood Hits	1044	Target Neighborhood Hits	895	Shared Neighborhood Hits	214
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

GOGB1_HUMAN
θ value	0.279714 (rank : 846)	NC score	0.080952 (rank : 956)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2297	Shared Neighborhood Hits	298
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

HDAC9_MOUSE
θ value	0.279714 (rank : 847)	NC score	0.030818 (rank : 1381)
Query Neighborhood Hits	1044	Target Neighborhood Hits	186	Shared Neighborhood Hits	75
SwissProt Accessions	Q99N13, Q9EPT2	Gene names	Hdac9, Hdac7b, Hdrp, Mitr
Domain Architecture	No domain graphic available
Description	Histone deacetylase 9 (HD9) (HD7B) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR).

IGBP1_MOUSE
θ value	0.279714 (rank : 848)	NC score	0.012056 (rank : 1412)
Query Neighborhood Hits	1044	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	Q61249	Gene names	Igbp1, Pc52
Domain Architecture
Description	Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (Alpha4 phosphoprotein) (Lymphocyte signal transduction molecule alpha 4) (p52).

KIF4A_HUMAN
θ value	0.279714 (rank : 849)	NC score	0.061801 (rank : 1175)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1159	Shared Neighborhood Hits	231
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIT_HUMAN
θ value	0.279714 (rank : 850)	NC score	0.630784 (rank : 785)
Query Neighborhood Hits	1044	Target Neighborhood Hits	953	Shared Neighborhood Hits	745
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

NUMA1_HUMAN
θ value	0.279714 (rank : 851)	NC score	0.073447 (rank : 1053)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1523	Shared Neighborhood Hits	240
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

RAD50_HUMAN
θ value	0.279714 (rank : 852)	NC score	0.083486 (rank : 918)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1317	Shared Neighborhood Hits	236
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

TYRO3_MOUSE
θ value	0.279714 (rank : 853)	NC score	0.662711 (rank : 762)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1007	Shared Neighborhood Hits	725
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

CT2NL_MOUSE
θ value	0.365318 (rank : 854)	NC score	0.080832 (rank : 958)
Query Neighborhood Hits	1044	Target Neighborhood Hits	902	Shared Neighborhood Hits	214
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

GOGA1_HUMAN
θ value	0.365318 (rank : 855)	NC score	0.081718 (rank : 942)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1222	Shared Neighborhood Hits	234
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA6_HUMAN
θ value	0.365318 (rank : 856)	NC score	0.080391 (rank : 963)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1007	Shared Neighborhood Hits	220
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

KS6C1_MOUSE
θ value	0.365318 (rank : 857)	NC score	0.713805 (rank : 677)
Query Neighborhood Hits	1044	Target Neighborhood Hits	700	Shared Neighborhood Hits	616
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

MYH14_HUMAN
θ value	0.365318 (rank : 858)	NC score	0.082006 (rank : 934)
Query Neighborhood Hits	1044	Target Neighborhood Hits	995	Shared Neighborhood Hits	187
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

B3A3_HUMAN
θ value	0.47712 (rank : 859)	NC score	0.000972 (rank : 1439)
Query Neighborhood Hits	1044	Target Neighborhood Hits	119	Shared Neighborhood Hits	12
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

BRE1A_HUMAN
θ value	0.47712 (rank : 860)	NC score	0.072687 (rank : 1058)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1071	Shared Neighborhood Hits	198
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BRE1B_MOUSE
θ value	0.47712 (rank : 861)	NC score	0.078230 (rank : 998)
Query Neighborhood Hits	1044	Target Neighborhood Hits	970	Shared Neighborhood Hits	206
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

CDC7_HUMAN
θ value	0.47712 (rank : 862)	NC score	0.730808 (rank : 638)
Query Neighborhood Hits	1044	Target Neighborhood Hits	652	Shared Neighborhood Hits	615
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

HDAC9_HUMAN
θ value	0.47712 (rank : 863)	NC score	0.014433 (rank : 1405)
Query Neighborhood Hits	1044	Target Neighborhood Hits	201	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UKV0, O94845, O95028	Gene names	HDAC9, HDAC7, HDAC7B, KIAA0744
Domain Architecture
Description	Histone deacetylase 9 (HD9) (HD7B) (HD7).

KINH_HUMAN
θ value	0.47712 (rank : 864)	NC score	0.059428 (rank : 1223)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1231	Shared Neighborhood Hits	240
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

MLL3_HUMAN
θ value	0.47712 (rank : 865)	NC score	0.018016 (rank : 1396)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1644	Shared Neighborhood Hits	143
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MLL3_MOUSE
θ value	0.47712 (rank : 866)	NC score	0.016523 (rank : 1399)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1399	Shared Neighborhood Hits	122
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

MYO5A_HUMAN
θ value	0.47712 (rank : 867)	NC score	0.081341 (rank : 951)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1092	Shared Neighborhood Hits	230
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

PCNT_MOUSE
θ value	0.47712 (rank : 868)	NC score	0.081243 (rank : 953)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1207	Shared Neighborhood Hits	230
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

TRIP4_HUMAN
θ value	0.47712 (rank : 869)	NC score	0.014185 (rank : 1407)
Query Neighborhood Hits	1044	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q15650, Q96ED7, Q9UKH0	Gene names	TRIP4
Domain Architecture
Description	Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TRIP-4).

BRAP_HUMAN
θ value	0.62314 (rank : 870)	NC score	0.052819 (rank : 1324)
Query Neighborhood Hits	1044	Target Neighborhood Hits	560	Shared Neighborhood Hits	146
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

CDC7_MOUSE
θ value	0.62314 (rank : 871)	NC score	0.724696 (rank : 649)
Query Neighborhood Hits	1044	Target Neighborhood Hits	641	Shared Neighborhood Hits	615
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CHD1_MOUSE
θ value	0.62314 (rank : 872)	NC score	0.001076 (rank : 1437)
Query Neighborhood Hits	1044	Target Neighborhood Hits	266	Shared Neighborhood Hits	28
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CJ118_MOUSE
θ value	0.62314 (rank : 873)	NC score	0.077412 (rank : 1001)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1132	Shared Neighborhood Hits	228
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

CSF1R_MOUSE
θ value	0.62314 (rank : 874)	NC score	0.589898 (rank : 812)
Query Neighborhood Hits	1044	Target Neighborhood Hits	983	Shared Neighborhood Hits	741
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

INCE_MOUSE
θ value	0.62314 (rank : 875)	NC score	0.090302 (rank : 879)
Query Neighborhood Hits	1044	Target Neighborhood Hits	903	Shared Neighborhood Hits	194
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

PEPL_HUMAN
θ value	0.62314 (rank : 876)	NC score	0.076906 (rank : 1010)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1141	Shared Neighborhood Hits	233
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

PLCB4_HUMAN
θ value	0.62314 (rank : 877)	NC score	0.070223 (rank : 1089)
Query Neighborhood Hits	1044	Target Neighborhood Hits	658	Shared Neighborhood Hits	204
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

REST_MOUSE
θ value	0.62314 (rank : 878)	NC score	0.076509 (rank : 1013)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1506	Shared Neighborhood Hits	242
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

ZC3H5_MOUSE
θ value	0.62314 (rank : 879)	NC score	0.014012 (rank : 1408)
Query Neighborhood Hits	1044	Target Neighborhood Hits	136	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

BUB1_MOUSE
θ value	0.813845 (rank : 880)	NC score	0.601830 (rank : 808)
Query Neighborhood Hits	1044	Target Neighborhood Hits	583	Shared Neighborhood Hits	537
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CB010_HUMAN
θ value	0.813845 (rank : 881)	NC score	0.023561 (rank : 1386)
Query Neighborhood Hits	1044	Target Neighborhood Hits	130	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z570, Q6ZN26	Gene names	C2orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf10.

CCD91_HUMAN
θ value	0.813845 (rank : 882)	NC score	0.078550 (rank : 994)
Query Neighborhood Hits	1044	Target Neighborhood Hits	868	Shared Neighborhood Hits	221
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CJ118_HUMAN
θ value	0.813845 (rank : 883)	NC score	0.070913 (rank : 1079)
Query Neighborhood Hits	1044	Target Neighborhood Hits	937	Shared Neighborhood Hits	197
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

FYCO1_HUMAN
θ value	0.813845 (rank : 884)	NC score	0.062800 (rank : 1165)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1149	Shared Neighborhood Hits	221
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

KIF3C_MOUSE
θ value	0.813845 (rank : 885)	NC score	0.034336 (rank : 1375)
Query Neighborhood Hits	1044	Target Neighborhood Hits	468	Shared Neighborhood Hits	145
SwissProt Accessions	O35066, O35229	Gene names	Kif3c
Domain Architecture
Description	Kinesin-like protein KIF3C.

PMYT1_MOUSE
θ value	0.813845 (rank : 886)	NC score	0.869459 (rank : 433)
Query Neighborhood Hits	1044	Target Neighborhood Hits	910	Shared Neighborhood Hits	769
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

SAFB1_HUMAN
θ value	0.813845 (rank : 887)	NC score	0.030405 (rank : 1382)
Query Neighborhood Hits	1044	Target Neighborhood Hits	493	Shared Neighborhood Hits	100
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

SKIL_HUMAN
θ value	0.813845 (rank : 888)	NC score	0.051448 (rank : 1340)
Query Neighborhood Hits	1044	Target Neighborhood Hits	460	Shared Neighborhood Hits	137
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

STYK1_HUMAN
θ value	0.813845 (rank : 889)	NC score	0.690221 (rank : 721)
Query Neighborhood Hits	1044	Target Neighborhood Hits	786	Shared Neighborhood Hits	723
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

TNIP3_HUMAN
θ value	0.813845 (rank : 890)	NC score	0.069136 (rank : 1096)
Query Neighborhood Hits	1044	Target Neighborhood Hits	511	Shared Neighborhood Hits	167
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

TPM3_HUMAN
θ value	0.813845 (rank : 891)	NC score	0.060338 (rank : 1200)
Query Neighborhood Hits	1044	Target Neighborhood Hits	689	Shared Neighborhood Hits	169
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

AVR2B_HUMAN
θ value	1.06291 (rank : 892)	NC score	0.692010 (rank : 719)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	700
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	1.06291 (rank : 893)	NC score	0.692054 (rank : 718)
Query Neighborhood Hits	1044	Target Neighborhood Hits	749	Shared Neighborhood Hits	700
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

CCD43_MOUSE
θ value	1.06291 (rank : 894)	NC score	0.020977 (rank : 1391)
Query Neighborhood Hits	1044	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	Q9CR29, Q6PDT2	Gene names	Ccdc43, D11Ertd707e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 43.

CNKR2_HUMAN
θ value	1.06291 (rank : 895)	NC score	0.005408 (rank : 1426)
Query Neighborhood Hits	1044	Target Neighborhood Hits	197	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	1.06291 (rank : 896)	NC score	0.005395 (rank : 1427)
Query Neighborhood Hits	1044	Target Neighborhood Hits	197	Shared Neighborhood Hits	20
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

GOGA4_HUMAN
θ value	1.06291 (rank : 897)	NC score	0.081349 (rank : 950)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2034	Shared Neighborhood Hits	278
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

KIF3C_HUMAN
θ value	1.06291 (rank : 898)	NC score	0.032586 (rank : 1379)
Query Neighborhood Hits	1044	Target Neighborhood Hits	478	Shared Neighborhood Hits	143
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

KS6C1_HUMAN
θ value	1.06291 (rank : 899)	NC score	0.708423 (rank : 691)
Query Neighborhood Hits	1044	Target Neighborhood Hits	682	Shared Neighborhood Hits	618
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KTN1_MOUSE
θ value	1.06291 (rank : 900)	NC score	0.078809 (rank : 986)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1324	Shared Neighborhood Hits	240
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LRC27_HUMAN
θ value	1.06291 (rank : 901)	NC score	0.041001 (rank : 1365)
Query Neighborhood Hits	1044	Target Neighborhood Hits	710	Shared Neighborhood Hits	160
SwissProt Accessions	Q9C0I9, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21	Gene names	LRRC27, KIAA1674
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

SKIL_MOUSE
θ value	1.06291 (rank : 902)	NC score	0.062464 (rank : 1168)
Query Neighborhood Hits	1044	Target Neighborhood Hits	719	Shared Neighborhood Hits	196
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SOX13_MOUSE
θ value	1.06291 (rank : 903)	NC score	0.005582 (rank : 1425)
Query Neighborhood Hits	1044	Target Neighborhood Hits	495	Shared Neighborhood Hits	47
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

TPR_HUMAN
θ value	1.06291 (rank : 904)	NC score	0.079495 (rank : 973)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1921	Shared Neighborhood Hits	275
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CENPF_HUMAN
θ value	1.38821 (rank : 905)	NC score	0.079465 (rank : 977)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1932	Shared Neighborhood Hits	268
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CEP35_HUMAN
θ value	1.38821 (rank : 906)	NC score	0.059461 (rank : 1221)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	197
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CP135_MOUSE
θ value	1.38821 (rank : 907)	NC score	0.082221 (rank : 929)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1278	Shared Neighborhood Hits	241
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

GCP60_MOUSE
θ value	1.38821 (rank : 908)	NC score	0.054201 (rank : 1303)
Query Neighborhood Hits	1044	Target Neighborhood Hits	395	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BMP6, O35371	Gene names	Acbd3, Gcp60, Pap7
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

GCYB2_HUMAN
θ value	1.38821 (rank : 909)	NC score	0.012848 (rank : 1411)
Query Neighborhood Hits	1044	Target Neighborhood Hits	61	Shared Neighborhood Hits	17
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

GOGA3_HUMAN
θ value	1.38821 (rank : 910)	NC score	0.075647 (rank : 1027)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1317	Shared Neighborhood Hits	228
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA3_MOUSE
θ value	1.38821 (rank : 911)	NC score	0.079194 (rank : 981)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1437	Shared Neighborhood Hits	238
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

K0494_HUMAN
θ value	1.38821 (rank : 912)	NC score	0.044537 (rank : 1360)
Query Neighborhood Hits	1044	Target Neighborhood Hits	230	Shared Neighborhood Hits	92
SwissProt Accessions	O75071	Gene names	KIAA0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

KIF3A_HUMAN
θ value	1.38821 (rank : 913)	NC score	0.032888 (rank : 1378)
Query Neighborhood Hits	1044	Target Neighborhood Hits	704	Shared Neighborhood Hits	178
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

MYO5A_MOUSE
θ value	1.38821 (rank : 914)	NC score	0.078315 (rank : 997)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1117	Shared Neighborhood Hits	226
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

PCNT_HUMAN
θ value	1.38821 (rank : 915)	NC score	0.081781 (rank : 940)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1551	Shared Neighborhood Hits	253
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

RRBP1_HUMAN
θ value	1.38821 (rank : 916)	NC score	0.061140 (rank : 1186)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1306	Shared Neighborhood Hits	226
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

VRK2_HUMAN
θ value	1.38821 (rank : 917)	NC score	0.493252 (rank : 825)
Query Neighborhood Hits	1044	Target Neighborhood Hits	582	Shared Neighborhood Hits	544
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

ZCPW1_MOUSE
θ value	1.38821 (rank : 918)	NC score	0.018811 (rank : 1395)
Query Neighborhood Hits	1044	Target Neighborhood Hits	307	Shared Neighborhood Hits	49
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

ACVL1_MOUSE
θ value	1.81305 (rank : 919)	NC score	0.652269 (rank : 774)
Query Neighborhood Hits	1044	Target Neighborhood Hits	739	Shared Neighborhood Hits	697
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

EEA1_MOUSE
θ value	1.81305 (rank : 920)	NC score	0.070296 (rank : 1088)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1637	Shared Neighborhood Hits	254
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

GGA1_MOUSE
θ value	1.81305 (rank : 921)	NC score	0.009796 (rank : 1416)
Query Neighborhood Hits	1044	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

HMMR_HUMAN
θ value	1.81305 (rank : 922)	NC score	0.075752 (rank : 1023)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1082	Shared Neighborhood Hits	211
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

KIF3A_MOUSE
θ value	1.81305 (rank : 923)	NC score	0.033787 (rank : 1377)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	187
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF4A_MOUSE
θ value	1.81305 (rank : 924)	NC score	0.053851 (rank : 1310)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1033	Shared Neighborhood Hits	218
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

LUZP1_MOUSE
θ value	1.81305 (rank : 925)	NC score	0.072468 (rank : 1059)
Query Neighborhood Hits	1044	Target Neighborhood Hits	940	Shared Neighborhood Hits	208
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

NAF1_MOUSE
θ value	1.81305 (rank : 926)	NC score	0.078749 (rank : 990)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	217
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

PHLB1_MOUSE
θ value	1.81305 (rank : 927)	NC score	0.044441 (rank : 1361)
Query Neighborhood Hits	1044	Target Neighborhood Hits	678	Shared Neighborhood Hits	151
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

STABP_MOUSE
θ value	1.81305 (rank : 928)	NC score	0.020538 (rank : 1392)
Query Neighborhood Hits	1044	Target Neighborhood Hits	191	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CQ26, Q3UTI9	Gene names	Stambp, Amsh
Domain Architecture	No domain graphic available
Description	STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3 domain of STAM).

ZFAN6_MOUSE
θ value	1.81305 (rank : 929)	NC score	0.016098 (rank : 1400)
Query Neighborhood Hits	1044	Target Neighborhood Hits	92	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DCH6, Q9ER79	Gene names	Zfand6, Awp1, Za20d3
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 6 (Zinc finger A20 domain-containing protein 3) (Associated with PRK1 protein).

AMOL1_MOUSE
θ value	2.36792 (rank : 930)	NC score	0.043442 (rank : 1362)
Query Neighborhood Hits	1044	Target Neighborhood Hits	445	Shared Neighborhood Hits	140
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

ANR12_HUMAN
θ value	2.36792 (rank : 931)	NC score	0.045904 (rank : 1358)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1081	Shared Neighborhood Hits	177
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

CCD41_HUMAN
θ value	2.36792 (rank : 932)	NC score	0.082146 (rank : 932)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1139	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD91_MOUSE
θ value	2.36792 (rank : 933)	NC score	0.077412 (rank : 1000)
Query Neighborhood Hits	1044	Target Neighborhood Hits	699	Shared Neighborhood Hits	198
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

INVO_HUMAN
θ value	2.36792 (rank : 934)	NC score	0.086804 (rank : 896)
Query Neighborhood Hits	1044	Target Neighborhood Hits	636	Shared Neighborhood Hits	170
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

IRAK2_HUMAN
θ value	2.36792 (rank : 935)	NC score	0.697111 (rank : 713)
Query Neighborhood Hits	1044	Target Neighborhood Hits	714	Shared Neighborhood Hits	638
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

K2002_HUMAN
θ value	2.36792 (rank : 936)	NC score	0.327049 (rank : 843)
Query Neighborhood Hits	1044	Target Neighborhood Hits	274	Shared Neighborhood Hits	255
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

NPTX2_MOUSE
θ value	2.36792 (rank : 937)	NC score	0.003988 (rank : 1431)
Query Neighborhood Hits	1044	Target Neighborhood Hits	79	Shared Neighborhood Hits	23
SwissProt Accessions	O70340	Gene names	Nptx2
Domain Architecture
Description	Neuronal pentraxin-2 precursor (NP2) (Neuronal pentraxin II) (NP-II).

PHLB2_HUMAN
θ value	2.36792 (rank : 938)	NC score	0.075469 (rank : 1029)
Query Neighborhood Hits	1044	Target Neighborhood Hits	964	Shared Neighborhood Hits	223
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
θ value	2.36792 (rank : 939)	NC score	0.076070 (rank : 1019)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1016	Shared Neighborhood Hits	231
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

TBP_MOUSE
θ value	2.36792 (rank : 940)	NC score	0.007564 (rank : 1421)
Query Neighborhood Hits	1044	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	P29037, O09169, Q80UL8, Q8C3S1	Gene names	Tbp, Tfiid
Domain Architecture
Description	TATA-box-binding protein (TATA-box factor) (TATA-binding factor) (TATA sequence-binding protein) (Transcription initiation factor TFIID TBP subunit).

TPM3_MOUSE
θ value	2.36792 (rank : 941)	NC score	0.058845 (rank : 1231)
Query Neighborhood Hits	1044	Target Neighborhood Hits	676	Shared Neighborhood Hits	168
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

ACVL1_HUMAN
θ value	3.0926 (rank : 942)	NC score	0.628926 (rank : 786)
Query Neighborhood Hits	1044	Target Neighborhood Hits	716	Shared Neighborhood Hits	672
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

CCD39_HUMAN
θ value	3.0926 (rank : 943)	NC score	0.075086 (rank : 1033)
Query Neighborhood Hits	1044	Target Neighborhood Hits	868	Shared Neighborhood Hits	204
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

DDX23_HUMAN
θ value	3.0926 (rank : 944)	NC score	0.011474 (rank : 1415)
Query Neighborhood Hits	1044	Target Neighborhood Hits	486	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

FLIP1_HUMAN
θ value	3.0926 (rank : 945)	NC score	0.076588 (rank : 1012)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1405	Shared Neighborhood Hits	249
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLIP1_MOUSE
θ value	3.0926 (rank : 946)	NC score	0.073699 (rank : 1045)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1176	Shared Neighborhood Hits	236
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GAGD4_HUMAN
θ value	3.0926 (rank : 947)	NC score	0.000682 (rank : 1441)
Query Neighborhood Hits	1044	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WTP9, Q5JS82, Q8WYS9	Gene names	XAGE3, GAGED4, PLAC6
Domain Architecture
Description	G antigen family D member 4 (Placenta-specific gene 6 protein) (Protein XAGE-3).

KINH_MOUSE
θ value	3.0926 (rank : 948)	NC score	0.053224 (rank : 1318)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1082	Shared Neighborhood Hits	225
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

LIPA1_HUMAN
θ value	3.0926 (rank : 949)	NC score	0.070718 (rank : 1085)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1294	Shared Neighborhood Hits	242
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

NDEL1_HUMAN
θ value	3.0926 (rank : 950)	NC score	0.049115 (rank : 1354)
Query Neighborhood Hits	1044	Target Neighborhood Hits	415	Shared Neighborhood Hits	139
SwissProt Accessions	Q9GZM8, Q86T80, Q8TAR7, Q9UH50	Gene names	NDEL1, EOPA, MITAP1, NUDEL
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin- associated protein 1).

NDEL1_MOUSE
θ value	3.0926 (rank : 951)	NC score	0.048902 (rank : 1355)
Query Neighborhood Hits	1044	Target Neighborhood Hits	420	Shared Neighborhood Hits	141
SwissProt Accessions	Q9ERR1, Q9D0Q4, Q9EPT6	Gene names	Ndel1, Nudel
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Protein mNudE-like) (mNudE-L).

NIN_HUMAN
θ value	3.0926 (rank : 952)	NC score	0.081799 (rank : 939)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1416	Shared Neighborhood Hits	251
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

RADI_HUMAN
θ value	3.0926 (rank : 953)	NC score	0.038994 (rank : 1369)
Query Neighborhood Hits	1044	Target Neighborhood Hits	741	Shared Neighborhood Hits	175
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RFIP4_MOUSE
θ value	3.0926 (rank : 954)	NC score	0.063468 (rank : 1152)
Query Neighborhood Hits	1044	Target Neighborhood Hits	708	Shared Neighborhood Hits	195
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

SAFB2_MOUSE
θ value	3.0926 (rank : 955)	NC score	0.045185 (rank : 1359)
Query Neighborhood Hits	1044	Target Neighborhood Hits	581	Shared Neighborhood Hits	142
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

SMC1A_HUMAN
θ value	3.0926 (rank : 956)	NC score	0.075764 (rank : 1022)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1346	Shared Neighborhood Hits	242
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

ZC3H5_HUMAN
θ value	3.0926 (rank : 957)	NC score	0.013717 (rank : 1409)
Query Neighborhood Hits	1044	Target Neighborhood Hits	134	Shared Neighborhood Hits	29
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

ZFAN6_HUMAN
θ value	3.0926 (rank : 958)	NC score	0.008120 (rank : 1420)
Query Neighborhood Hits	1044	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	Q6FIF0, O95792, Q9BQF7, Q9GZY3	Gene names	ZFAND6, AWP1, ZA20D3
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 6 (Zinc finger A20 domain-containing protein 3) (Associated with PRK1 protein).

ZN291_HUMAN
θ value	3.0926 (rank : 959)	NC score	0.073589 (rank : 1048)
Query Neighborhood Hits	1044	Target Neighborhood Hits	647	Shared Neighborhood Hits	170
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

BRD3_MOUSE
θ value	4.03905 (rank : 960)	NC score	0.011799 (rank : 1413)
Query Neighborhood Hits	1044	Target Neighborhood Hits	402	Shared Neighborhood Hits	96
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

CP24A_MOUSE
θ value	4.03905 (rank : 961)	NC score	-0.004710 (rank : 1453)
Query Neighborhood Hits	1044	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q64441	Gene names	Cyp24a1, Cyp-24, Cyp24
Domain Architecture
Description	Cytochrome P450 24A1, mitochondrial precursor (EC 1.14.-.-) (P450- CC24) (Vitamin D(3) 24-hydroxylase) (1,25-dihydroxyvitamin D(3) 24- hydroxylase) (24-OHase).

CTGE5_HUMAN
θ value	4.03905 (rank : 962)	NC score	0.055072 (rank : 1290)
Query Neighborhood Hits	1044	Target Neighborhood Hits	800	Shared Neighborhood Hits	194
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

F126A_HUMAN
θ value	4.03905 (rank : 963)	NC score	0.006334 (rank : 1424)
Query Neighborhood Hits	1044	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYI3, Q6N010, Q75MR4, Q7LDZ4, Q96MX1, Q96NQ6	Gene names	FAM126A, DRCTNNB1A
Domain Architecture	No domain graphic available
Description	Protein FAM126A (Down-regulated by CTNNB1 protein A).

HOOK1_HUMAN
θ value	4.03905 (rank : 964)	NC score	0.064805 (rank : 1134)
Query Neighborhood Hits	1044	Target Neighborhood Hits	942	Shared Neighborhood Hits	206
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

IRS2_HUMAN
θ value	4.03905 (rank : 965)	NC score	0.009378 (rank : 1417)
Query Neighborhood Hits	1044	Target Neighborhood Hits	262	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

NOC2L_HUMAN
θ value	4.03905 (rank : 966)	NC score	0.015243 (rank : 1402)
Query Neighborhood Hits	1044	Target Neighborhood Hits	49	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y3T9, Q5SVA3, Q9BTN6	Gene names	NOC2L
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

RN168_MOUSE
θ value	4.03905 (rank : 967)	NC score	0.014480 (rank : 1404)
Query Neighborhood Hits	1044	Target Neighborhood Hits	440	Shared Neighborhood Hits	78
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

SART3_HUMAN
θ value	4.03905 (rank : 968)	NC score	-0.001454 (rank : 1449)
Query Neighborhood Hits	1044	Target Neighborhood Hits	301	Shared Neighborhood Hits	36
SwissProt Accessions	Q15020, Q58F06, Q8IUS1, Q96J95	Gene names	SART3, KIAA0156, TIP110
Domain Architecture	No domain graphic available
Description	Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (hSART-3) (Tat-interacting protein of 110 kDa) (Tip110).

TTC16_HUMAN
θ value	4.03905 (rank : 969)	NC score	0.006845 (rank : 1423)
Query Neighborhood Hits	1044	Target Neighborhood Hits	417	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

UBP2L_MOUSE
θ value	4.03905 (rank : 970)	NC score	0.004839 (rank : 1430)
Query Neighborhood Hits	1044	Target Neighborhood Hits	173	Shared Neighborhood Hits	10
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

UHRF1_HUMAN
θ value	4.03905 (rank : 971)	NC score	-0.004415 (rank : 1452)
Query Neighborhood Hits	1044	Target Neighborhood Hits	272	Shared Neighborhood Hits	12
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

ASPC1_HUMAN
θ value	5.27518 (rank : 972)	NC score	0.005169 (rank : 1428)
Query Neighborhood Hits	1044	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BZE9, Q7Z6N7, Q8WV59, Q96LS5, Q96M40	Gene names	ASPSCR1, ASPL, RCC17, TUG
Domain Architecture	No domain graphic available
Description	Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosome region candidate 1) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17).

ASZ1_HUMAN
θ value	5.27518 (rank : 973)	NC score	0.016748 (rank : 1398)
Query Neighborhood Hits	1044	Target Neighborhood Hits	341	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ASZ1_MOUSE
θ value	5.27518 (rank : 974)	NC score	0.014332 (rank : 1406)
Query Neighborhood Hits	1044	Target Neighborhood Hits	319	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

BAZ2B_HUMAN
θ value	5.27518 (rank : 975)	NC score	0.039317 (rank : 1368)
Query Neighborhood Hits	1044	Target Neighborhood Hits	803	Shared Neighborhood Hits	165
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

C102B_HUMAN
θ value	5.27518 (rank : 976)	NC score	0.064507 (rank : 1137)
Query Neighborhood Hits	1044	Target Neighborhood Hits	542	Shared Neighborhood Hits	159
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

CP135_HUMAN
θ value	5.27518 (rank : 977)	NC score	0.079190 (rank : 983)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1290	Shared Neighborhood Hits	232
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CR034_MOUSE
θ value	5.27518 (rank : 978)	NC score	0.064429 (rank : 1138)
Query Neighborhood Hits	1044	Target Neighborhood Hits	643	Shared Neighborhood Hits	174
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

GOG8A_HUMAN
θ value	5.27518 (rank : 979)	NC score	0.069390 (rank : 1094)
Query Neighborhood Hits	1044	Target Neighborhood Hits	635	Shared Neighborhood Hits	195
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

HDAC5_MOUSE
θ value	5.27518 (rank : 980)	NC score	0.016072 (rank : 1401)
Query Neighborhood Hits	1044	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

HMMR_MOUSE
θ value	5.27518 (rank : 981)	NC score	0.077117 (rank : 1006)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1178	Shared Neighborhood Hits	229
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

HNF1B_MOUSE
θ value	5.27518 (rank : 982)	NC score	-0.000513 (rank : 1444)
Query Neighborhood Hits	1044	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	P27889, Q8R162, Q9CS26, Q9R1W1, Q9R1W2, Q9WTL5, Q9WTL6	Gene names	Tcf2, Hnf-1b, Hnf1b
Domain Architecture
Description	Hepatocyte nuclear factor 1-beta (HNF-1beta) (HNF-1B) (Variant hepatic nuclear factor 1) (VHNF1) (Homeoprotein LFB3).

INCE_HUMAN
θ value	5.27518 (rank : 983)	NC score	0.086380 (rank : 900)
Query Neighborhood Hits	1044	Target Neighborhood Hits	978	Shared Neighborhood Hits	197
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

NC6IP_HUMAN
θ value	5.27518 (rank : 984)	NC score	0.008139 (rank : 1419)
Query Neighborhood Hits	1044	Target Neighborhood Hits	116	Shared Neighborhood Hits	22
SwissProt Accessions	Q96RS0, Q5GH23, Q8TDG9, Q96QU3, Q9H5V3	Gene names	NCOA6IP, PIMT
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT) (CLL-associated antigen KW-2) (Hepatocellular carcinoma-associated antigen 137) (HCA137).

NOC2L_MOUSE
θ value	5.27518 (rank : 985)	NC score	0.014693 (rank : 1403)
Query Neighborhood Hits	1044	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV70, Q8VE16	Gene names	Noc2l
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

RAD50_MOUSE
θ value	5.27518 (rank : 986)	NC score	0.080482 (rank : 962)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1366	Shared Neighborhood Hits	236
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RUFY2_HUMAN
θ value	5.27518 (rank : 987)	NC score	0.057564 (rank : 1249)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1208	Shared Neighborhood Hits	223
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

SDS3_HUMAN
θ value	5.27518 (rank : 988)	NC score	0.031880 (rank : 1380)
Query Neighborhood Hits	1044	Target Neighborhood Hits	257	Shared Neighborhood Hits	97
SwissProt Accessions	Q9H7L9, Q8N6H0, Q9H8D2	Gene names	SUDS3, SDS3
Domain Architecture	No domain graphic available
Description	Sin3 histone deacetylase corepressor complex component SDS3 (Suppressor of defective silencing 3 protein homolog).

SMC1A_MOUSE
θ value	5.27518 (rank : 989)	NC score	0.079697 (rank : 969)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1384	Shared Neighborhood Hits	249
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SWP70_HUMAN
θ value	5.27518 (rank : 990)	NC score	0.080219 (rank : 966)
Query Neighborhood Hits	1044	Target Neighborhood Hits	973	Shared Neighborhood Hits	219
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TBCD4_MOUSE
θ value	5.27518 (rank : 991)	NC score	0.017282 (rank : 1397)
Query Neighborhood Hits	1044	Target Neighborhood Hits	276	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BYJ6, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2	Gene names	Tbc1d4, Kiaa0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

TMPSD_HUMAN
θ value	5.27518 (rank : 992)	NC score	-0.011422 (rank : 1455)
Query Neighborhood Hits	1044	Target Neighborhood Hits	333	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).

AP3B1_HUMAN
θ value	6.88961 (rank : 993)	NC score	-0.001141 (rank : 1445)
Query Neighborhood Hits	1044	Target Neighborhood Hits	283	Shared Neighborhood Hits	20
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

BRAP_MOUSE
θ value	6.88961 (rank : 994)	NC score	0.034678 (rank : 1374)
Query Neighborhood Hits	1044	Target Neighborhood Hits	409	Shared Neighborhood Hits	111
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

CAPS2_HUMAN
θ value	6.88961 (rank : 995)	NC score	0.005152 (rank : 1429)
Query Neighborhood Hits	1044	Target Neighborhood Hits	81	Shared Neighborhood Hits	26
SwissProt Accessions	Q86UW7, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8	Gene names	CADPS2, CAPS2, KIAA1591
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

HDAC5_HUMAN
θ value	6.88961 (rank : 996)	NC score	0.021306 (rank : 1390)
Query Neighborhood Hits	1044	Target Neighborhood Hits	353	Shared Neighborhood Hits	113
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

IF4B_HUMAN
θ value	6.88961 (rank : 997)	NC score	0.007192 (rank : 1422)
Query Neighborhood Hits	1044	Target Neighborhood Hits	417	Shared Neighborhood Hits	32
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

K0494_MOUSE
θ value	6.88961 (rank : 998)	NC score	0.035747 (rank : 1372)
Query Neighborhood Hits	1044	Target Neighborhood Hits	241	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BGQ6, Q3TQN6, Q8BJV7, Q8C0R1	Gene names	Kiaa0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

LRC45_MOUSE
θ value	6.88961 (rank : 999)	NC score	0.078498 (rank : 995)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	216
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRSM1_HUMAN
θ value	6.88961 (rank : 1000)	NC score	0.046006 (rank : 1357)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1078	Shared Neighborhood Hits	213
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MAP1A_HUMAN
θ value	6.88961 (rank : 1001)	NC score	0.062159 (rank : 1174)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1626	Shared Neighborhood Hits	258
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MYO10_HUMAN
θ value	6.88961 (rank : 1002)	NC score	0.071743 (rank : 1069)
Query Neighborhood Hits	1044	Target Neighborhood Hits	920	Shared Neighborhood Hits	213
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

NDE1_HUMAN
θ value	6.88961 (rank : 1003)	NC score	0.073492 (rank : 1052)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

RADI_MOUSE
θ value	6.88961 (rank : 1004)	NC score	0.040447 (rank : 1367)
Query Neighborhood Hits	1044	Target Neighborhood Hits	773	Shared Neighborhood Hits	171
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

SDCG8_MOUSE
θ value	6.88961 (rank : 1005)	NC score	0.077233 (rank : 1003)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	218
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SM1L2_MOUSE
θ value	6.88961 (rank : 1006)	NC score	0.074932 (rank : 1034)
Query Neighborhood Hits	1044	Target Neighborhood Hits	918	Shared Neighborhood Hits	216
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SORC2_HUMAN
θ value	6.88961 (rank : 1007)	NC score	0.001118 (rank : 1436)
Query Neighborhood Hits	1044	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

SRRM2_MOUSE
θ value	6.88961 (rank : 1008)	NC score	0.037157 (rank : 1371)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1470	Shared Neighborhood Hits	129
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TRI47_HUMAN
θ value	6.88961 (rank : 1009)	NC score	-0.009350 (rank : 1454)
Query Neighborhood Hits	1044	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

UACA_HUMAN
θ value	6.88961 (rank : 1010)	NC score	0.069787 (rank : 1091)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1622	Shared Neighborhood Hits	244
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

ZIM10_HUMAN
θ value	6.88961 (rank : 1011)	NC score	-0.001158 (rank : 1446)
Query Neighborhood Hits	1044	Target Neighborhood Hits	577	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZIM10_MOUSE
θ value	6.88961 (rank : 1012)	NC score	-0.002979 (rank : 1451)
Query Neighborhood Hits	1044	Target Neighborhood Hits	430	Shared Neighborhood Hits	19
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZN541_HUMAN
θ value	6.88961 (rank : 1013)	NC score	0.000106 (rank : 1442)
Query Neighborhood Hits	1044	Target Neighborhood Hits	203	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

ZWINT_HUMAN
θ value	6.88961 (rank : 1014)	NC score	0.055356 (rank : 1287)
Query Neighborhood Hits	1044	Target Neighborhood Hits	333	Shared Neighborhood Hits	141
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

ADCK1_HUMAN
θ value	8.99809 (rank : 1015)	NC score	0.013060 (rank : 1410)
Query Neighborhood Hits	1044	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	Q86TW2, Q6PD65	Gene names	ADCK1
Domain Architecture	No domain graphic available
Description	Uncharacterized aarF domain-containing protein kinase 1 precursor (EC 2.7.-.-).

AL2S2_HUMAN
θ value	8.99809 (rank : 1016)	NC score	0.777543 (rank : 578)
Query Neighborhood Hits	1044	Target Neighborhood Hits	727	Shared Neighborhood Hits	676
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

BOREA_HUMAN
θ value	8.99809 (rank : 1017)	NC score	0.002144 (rank : 1433)
Query Neighborhood Hits	1044	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q53HL2, Q53HN1, Q96AM3, Q9NVW5	Gene names	CDCA8, PESCRG3
Domain Architecture	No domain graphic available
Description	Borealin (Dasra-B) (hDasra-B) (Cell division cycle-associated protein 8) (Pluripotent embryonic stem cell-related gene 3 protein).

BPA1_MOUSE
θ value	8.99809 (rank : 1018)	NC score	0.055467 (rank : 1285)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1477	Shared Neighborhood Hits	240
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BTAF1_HUMAN
θ value	8.99809 (rank : 1019)	NC score	-0.001213 (rank : 1447)
Query Neighborhood Hits	1044	Target Neighborhood Hits	97	Shared Neighborhood Hits	6
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

CARD9_HUMAN
θ value	8.99809 (rank : 1020)	NC score	0.079093 (rank : 984)
Query Neighborhood Hits	1044	Target Neighborhood Hits	602	Shared Neighborhood Hits	196
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CCD46_MOUSE
θ value	8.99809 (rank : 1021)	NC score	0.085700 (rank : 905)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1405	Shared Neighborhood Hits	245
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CEP57_MOUSE
θ value	8.99809 (rank : 1022)	NC score	0.064661 (rank : 1135)
Query Neighborhood Hits	1044	Target Neighborhood Hits	580	Shared Neighborhood Hits	195
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

CN145_HUMAN
θ value	8.99809 (rank : 1023)	NC score	0.081876 (rank : 935)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1196	Shared Neighborhood Hits	239
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CS007_MOUSE
θ value	8.99809 (rank : 1024)	NC score	0.003173 (rank : 1432)
Query Neighborhood Hits	1044	Target Neighborhood Hits	464	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

DHX37_HUMAN
θ value	8.99809 (rank : 1025)	NC score	-0.001300 (rank : 1448)
Query Neighborhood Hits	1044	Target Neighborhood Hits	133	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IY37, Q9BUI7, Q9P211	Gene names	DHX37, DDX37, KIAA1517
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.1.-) (DEAH box protein 37).

DOCK3_HUMAN
θ value	8.99809 (rank : 1026)	NC score	0.000999 (rank : 1438)
Query Neighborhood Hits	1044	Target Neighborhood Hits	87	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	8.99809 (rank : 1027)	NC score	0.000962 (rank : 1440)
Query Neighborhood Hits	1044	Target Neighborhood Hits	93	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

EEA1_HUMAN
θ value	8.99809 (rank : 1028)	NC score	0.070487 (rank : 1087)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1796	Shared Neighborhood Hits	256
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ENAH_MOUSE
θ value	8.99809 (rank : 1029)	NC score	0.035411 (rank : 1373)
Query Neighborhood Hits	1044	Target Neighborhood Hits	919	Shared Neighborhood Hits	156
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EZRI_MOUSE
θ value	8.99809 (rank : 1030)	NC score	0.042030 (rank : 1364)
Query Neighborhood Hits	1044	Target Neighborhood Hits	693	Shared Neighborhood Hits	184
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FGFP3_HUMAN
θ value	8.99809 (rank : 1031)	NC score	0.001587 (rank : 1434)
Query Neighborhood Hits	1044	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TAT2, Q8NBN0	Gene names	FGFBP3, C10orf13
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor-binding protein 3 precursor (FGF-binding protein 3) (FGF-BP3) (FGFBP-3).

IF4G3_MOUSE
θ value	8.99809 (rank : 1032)	NC score	0.008282 (rank : 1418)
Query Neighborhood Hits	1044	Target Neighborhood Hits	279	Shared Neighborhood Hits	67
SwissProt Accessions	Q80XI3, Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0	Gene names	Eif4g3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

KMHN1_MOUSE
θ value	8.99809 (rank : 1033)	NC score	0.072921 (rank : 1056)
Query Neighborhood Hits	1044	Target Neighborhood Hits	949	Shared Neighborhood Hits	212
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

LIPA2_HUMAN
θ value	8.99809 (rank : 1034)	NC score	0.063607 (rank : 1148)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1044	Shared Neighborhood Hits	223
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

POT15_HUMAN
θ value	8.99809 (rank : 1035)	NC score	0.034275 (rank : 1376)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	195
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

PSA_HUMAN
θ value	8.99809 (rank : 1036)	NC score	-0.002187 (rank : 1450)
Query Neighborhood Hits	1044	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P55786, Q6P145, Q9NP16, Q9UEM2	Gene names	NPEPPS, PSA
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

SCAM3_MOUSE
θ value	8.99809 (rank : 1037)	NC score	-0.000352 (rank : 1443)
Query Neighborhood Hits	1044	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	O35609, Q99M48, Q9ERM9	Gene names	Scamp3
Domain Architecture
Description	Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3).

SFR16_HUMAN
θ value	8.99809 (rank : 1038)	NC score	0.019141 (rank : 1394)
Query Neighborhood Hits	1044	Target Neighborhood Hits	178	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N2M8, O96026, Q6UW71, Q96DX2	Gene names	SFRS16, SWAP2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2).

SFR16_MOUSE
θ value	8.99809 (rank : 1039)	NC score	0.022624 (rank : 1389)
Query Neighborhood Hits	1044	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

SNP25_HUMAN
θ value	8.99809 (rank : 1040)	NC score	0.023887 (rank : 1384)
Query Neighborhood Hits	1044	Target Neighborhood Hits	96	Shared Neighborhood Hits	49
SwissProt Accessions	P60880, P13795, P36974, P70557, P70558, Q8IXK3, Q96FM2, Q9BR45	Gene names	SNAP25, SNAP
Domain Architecture
Description	Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) (Super protein) (SUP).

SNP25_MOUSE
θ value	8.99809 (rank : 1041)	NC score	0.023887 (rank : 1385)
Query Neighborhood Hits	1044	Target Neighborhood Hits	96	Shared Neighborhood Hits	49
SwissProt Accessions	P60879, P13795, P36974, P70557, P70558, Q8IXK3, Q96FM2, Q9BR45	Gene names	Snap25, Snap
Domain Architecture
Description	Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) (Super protein) (SUP).

TACC3_HUMAN
θ value	8.99809 (rank : 1042)	NC score	0.050082 (rank : 1353)
Query Neighborhood Hits	1044	Target Neighborhood Hits	779	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

WDR60_MOUSE
θ value	8.99809 (rank : 1043)	NC score	0.037847 (rank : 1370)
Query Neighborhood Hits	1044	Target Neighborhood Hits	344	Shared Neighborhood Hits	92
SwissProt Accessions	Q8C761, Q3UNM4	Gene names	Wdr60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

WWTR1_HUMAN
θ value	8.99809 (rank : 1044)	NC score	0.001325 (rank : 1435)
Query Neighborhood Hits	1044	Target Neighborhood Hits	76	Shared Neighborhood Hits	7
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

3BP5_HUMAN
θ value	θ > 10 (rank : 1045)	NC score	0.060057 (rank : 1208)
Query Neighborhood Hits	1044	Target Neighborhood Hits	375	Shared Neighborhood Hits	132
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

3BP5_MOUSE
θ value	θ > 10 (rank : 1046)	NC score	0.054654 (rank : 1297)
Query Neighborhood Hits	1044	Target Neighborhood Hits	346	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

AATK_HUMAN
θ value	θ > 10 (rank : 1047)	NC score	0.679701 (rank : 734)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1243	Shared Neighborhood Hits	727
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 1048)	NC score	0.668977 (rank : 756)
Query Neighborhood Hits	1044	Target Neighborhood Hits	942	Shared Neighborhood Hits	710
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ACK1_HUMAN
θ value	θ > 10 (rank : 1049)	NC score	0.707273 (rank : 692)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1140	Shared Neighborhood Hits	762
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
θ value	θ > 10 (rank : 1050)	NC score	0.705947 (rank : 696)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1080	Shared Neighborhood Hits	761
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ADIP_HUMAN
θ value	θ > 10 (rank : 1051)	NC score	0.060944 (rank : 1191)
Query Neighborhood Hits	1044	Target Neighborhood Hits	470	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

ADIP_MOUSE
θ value	θ > 10 (rank : 1052)	NC score	0.056329 (rank : 1271)
Query Neighborhood Hits	1044	Target Neighborhood Hits	415	Shared Neighborhood Hits	153
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

AL2S2_MOUSE
θ value	θ > 10 (rank : 1053)	NC score	0.763717 (rank : 595)
Query Neighborhood Hits	1044	Target Neighborhood Hits	709	Shared Neighborhood Hits	660
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

AL2SB_HUMAN
θ value	θ > 10 (rank : 1054)	NC score	0.060886 (rank : 1193)
Query Neighborhood Hits	1044	Target Neighborhood Hits	294	Shared Neighborhood Hits	112
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

AMHR2_HUMAN
θ value	θ > 10 (rank : 1055)	NC score	0.555678 (rank : 817)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	621
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

AMOL2_HUMAN
θ value	θ > 10 (rank : 1056)	NC score	0.063591 (rank : 1149)
Query Neighborhood Hits	1044	Target Neighborhood Hits	603	Shared Neighborhood Hits	183
SwissProt Accessions	Q9Y2J4, Q53EP1, Q96F99, Q9UKB4	Gene names	AMOTL2, KIAA0989
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP).

AMOL2_MOUSE
θ value	θ > 10 (rank : 1057)	NC score	0.054925 (rank : 1293)
Query Neighborhood Hits	1044	Target Neighborhood Hits	591	Shared Neighborhood Hits	169
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

AN30A_HUMAN
θ value	θ > 10 (rank : 1058)	NC score	0.065641 (rank : 1125)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1119	Shared Neighborhood Hits	218
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ANR26_HUMAN
θ value	θ > 10 (rank : 1059)	NC score	0.068897 (rank : 1099)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1614	Shared Neighborhood Hits	251
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANR26_MOUSE
θ value	θ > 10 (rank : 1060)	NC score	0.070871 (rank : 1082)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1554	Shared Neighborhood Hits	248
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

APOA4_HUMAN
θ value	θ > 10 (rank : 1061)	NC score	0.059350 (rank : 1224)
Query Neighborhood Hits	1044	Target Neighborhood Hits	399	Shared Neighborhood Hits	125
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

APOA4_MOUSE
θ value	θ > 10 (rank : 1062)	NC score	0.054688 (rank : 1296)
Query Neighborhood Hits	1044	Target Neighborhood Hits	435	Shared Neighborhood Hits	135
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

APOE_MOUSE
θ value	θ > 10 (rank : 1063)	NC score	0.057103 (rank : 1261)
Query Neighborhood Hits	1044	Target Neighborhood Hits	319	Shared Neighborhood Hits	120
SwissProt Accessions	P08226	Gene names	Apoe
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

ASPP2_HUMAN
θ value	θ > 10 (rank : 1064)	NC score	0.059044 (rank : 1227)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1156	Shared Neighborhood Hits	217
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

AZI1_HUMAN
θ value	θ > 10 (rank : 1065)	NC score	0.079390 (rank : 978)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1000	Shared Neighborhood Hits	221
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

AZI1_MOUSE
θ value	θ > 10 (rank : 1066)	NC score	0.073498 (rank : 1051)
Query Neighborhood Hits	1044	Target Neighborhood Hits	990	Shared Neighborhood Hits	220
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BICD1_HUMAN
θ value	θ > 10 (rank : 1067)	NC score	0.062970 (rank : 1162)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	194
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD1_MOUSE
θ value	θ > 10 (rank : 1068)	NC score	0.063479 (rank : 1151)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	194
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD2_HUMAN
θ value	θ > 10 (rank : 1069)	NC score	0.064886 (rank : 1132)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	201
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
θ value	θ > 10 (rank : 1070)	NC score	0.065112 (rank : 1131)
Query Neighborhood Hits	1044	Target Neighborhood Hits	864	Shared Neighborhood Hits	196
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BUB1B_HUMAN
θ value	θ > 10 (rank : 1071)	NC score	0.105942 (rank : 858)
Query Neighborhood Hits	1044	Target Neighborhood Hits	208	Shared Neighborhood Hits	144
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1B_MOUSE
θ value	θ > 10 (rank : 1072)	NC score	0.086250 (rank : 901)
Query Neighborhood Hits	1044	Target Neighborhood Hits	202	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

CA065_HUMAN
θ value	θ > 10 (rank : 1073)	NC score	0.079644 (rank : 970)
Query Neighborhood Hits	1044	Target Neighborhood Hits	469	Shared Neighborhood Hits	155
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

CAF1A_HUMAN
θ value	θ > 10 (rank : 1074)	NC score	0.059606 (rank : 1217)
Query Neighborhood Hits	1044	Target Neighborhood Hits	750	Shared Neighborhood Hits	178
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CAF1A_MOUSE
θ value	θ > 10 (rank : 1075)	NC score	0.060140 (rank : 1204)
Query Neighborhood Hits	1044	Target Neighborhood Hits	736	Shared Neighborhood Hits	181
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CAR10_HUMAN
θ value	θ > 10 (rank : 1076)	NC score	0.051395 (rank : 1341)
Query Neighborhood Hits	1044	Target Neighborhood Hits	569	Shared Neighborhood Hits	181
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CAR11_HUMAN
θ value	θ > 10 (rank : 1077)	NC score	0.060304 (rank : 1201)
Query Neighborhood Hits	1044	Target Neighborhood Hits	690	Shared Neighborhood Hits	196
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CASP_HUMAN
θ value	θ > 10 (rank : 1078)	NC score	0.069050 (rank : 1098)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1131	Shared Neighborhood Hits	226
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CASP_MOUSE
θ value	θ > 10 (rank : 1079)	NC score	0.069110 (rank : 1097)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1152	Shared Neighborhood Hits	227
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CCD11_HUMAN
θ value	θ > 10 (rank : 1080)	NC score	0.091556 (rank : 875)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	220
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD11_MOUSE
θ value	θ > 10 (rank : 1081)	NC score	0.081803 (rank : 938)
Query Neighborhood Hits	1044	Target Neighborhood Hits	498	Shared Neighborhood Hits	152
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD13_HUMAN
θ value	θ > 10 (rank : 1082)	NC score	0.071668 (rank : 1070)
Query Neighborhood Hits	1044	Target Neighborhood Hits	721	Shared Neighborhood Hits	186
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CCD21_HUMAN
θ value	θ > 10 (rank : 1083)	NC score	0.071168 (rank : 1077)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1228	Shared Neighborhood Hits	231
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	θ > 10 (rank : 1084)	NC score	0.080725 (rank : 960)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1135	Shared Neighborhood Hits	246
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD27_MOUSE
θ value	θ > 10 (rank : 1085)	NC score	0.063304 (rank : 1157)
Query Neighborhood Hits	1044	Target Neighborhood Hits	461	Shared Neighborhood Hits	145
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CCD39_MOUSE
θ value	θ > 10 (rank : 1086)	NC score	0.079298 (rank : 979)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1026	Shared Neighborhood Hits	220
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD41_MOUSE
θ value	θ > 10 (rank : 1087)	NC score	0.081777 (rank : 941)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1399	Shared Neighborhood Hits	246
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CCD42_HUMAN
θ value	θ > 10 (rank : 1088)	NC score	0.061287 (rank : 1180)
Query Neighborhood Hits	1044	Target Neighborhood Hits	406	Shared Neighborhood Hits	151
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

CCD45_HUMAN
θ value	θ > 10 (rank : 1089)	NC score	0.074063 (rank : 1042)
Query Neighborhood Hits	1044	Target Neighborhood Hits	525	Shared Neighborhood Hits	180
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCD45_MOUSE
θ value	θ > 10 (rank : 1090)	NC score	0.075853 (rank : 1020)
Query Neighborhood Hits	1044	Target Neighborhood Hits	663	Shared Neighborhood Hits	191
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCD46_HUMAN
θ value	θ > 10 (rank : 1091)	NC score	0.087621 (rank : 889)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1430	Shared Neighborhood Hits	257
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CCD62_HUMAN
θ value	θ > 10 (rank : 1092)	NC score	0.077098 (rank : 1007)
Query Neighborhood Hits	1044	Target Neighborhood Hits	631	Shared Neighborhood Hits	188
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

CCD93_HUMAN
θ value	θ > 10 (rank : 1093)	NC score	0.068423 (rank : 1102)
Query Neighborhood Hits	1044	Target Neighborhood Hits	600	Shared Neighborhood Hits	179
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD93_MOUSE
θ value	θ > 10 (rank : 1094)	NC score	0.058354 (rank : 1240)
Query Neighborhood Hits	1044	Target Neighborhood Hits	362	Shared Neighborhood Hits	137
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD96_HUMAN
θ value	θ > 10 (rank : 1095)	NC score	0.066694 (rank : 1116)
Query Neighborhood Hits	1044	Target Neighborhood Hits	595	Shared Neighborhood Hits	177
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCD96_MOUSE
θ value	θ > 10 (rank : 1096)	NC score	0.069603 (rank : 1093)
Query Neighborhood Hits	1044	Target Neighborhood Hits	704	Shared Neighborhood Hits	190
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCDC6_HUMAN
θ value	θ > 10 (rank : 1097)	NC score	0.070859 (rank : 1083)
Query Neighborhood Hits	1044	Target Neighborhood Hits	723	Shared Neighborhood Hits	204
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CCHCR_HUMAN
θ value	θ > 10 (rank : 1098)	NC score	0.071335 (rank : 1074)
Query Neighborhood Hits	1044	Target Neighborhood Hits	717	Shared Neighborhood Hits	183
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

CCHCR_MOUSE
θ value	θ > 10 (rank : 1099)	NC score	0.075750 (rank : 1024)
Query Neighborhood Hits	1044	Target Neighborhood Hits	932	Shared Neighborhood Hits	222
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CDC37_HUMAN
θ value	θ > 10 (rank : 1100)	NC score	0.054010 (rank : 1308)
Query Neighborhood Hits	1044	Target Neighborhood Hits	506	Shared Neighborhood Hits	167
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CDR2_MOUSE
θ value	θ > 10 (rank : 1101)	NC score	0.058590 (rank : 1235)
Query Neighborhood Hits	1044	Target Neighborhood Hits	482	Shared Neighborhood Hits	170
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

CE152_HUMAN
θ value	θ > 10 (rank : 1102)	NC score	0.081644 (rank : 944)
Query Neighborhood Hits	1044	Target Neighborhood Hits	976	Shared Neighborhood Hits	206
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CENPH_HUMAN
θ value	θ > 10 (rank : 1103)	NC score	0.051284 (rank : 1342)
Query Neighborhood Hits	1044	Target Neighborhood Hits	335	Shared Neighborhood Hits	138
SwissProt Accessions	Q9H3R5	Gene names	CENPH, ICEN35
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H) (Interphase centromere complex protein 35).

CENPJ_HUMAN
θ value	θ > 10 (rank : 1104)	NC score	0.060134 (rank : 1205)
Query Neighborhood Hits	1044	Target Neighborhood Hits	721	Shared Neighborhood Hits	199
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

CEP55_HUMAN
θ value	θ > 10 (rank : 1105)	NC score	0.067635 (rank : 1109)
Query Neighborhood Hits	1044	Target Neighborhood Hits	504	Shared Neighborhood Hits	173
SwissProt Accessions	Q53EZ4, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7	Gene names	CEP55, C10orf3, URCC6
Domain Architecture	No domain graphic available
Description	Centrosome protein 55 (Up-regulated in colon cancer 6).

CEP55_MOUSE
θ value	θ > 10 (rank : 1106)	NC score	0.065814 (rank : 1124)
Query Neighborhood Hits	1044	Target Neighborhood Hits	693	Shared Neighborhood Hits	191
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CEP57_HUMAN
θ value	θ > 10 (rank : 1107)	NC score	0.064159 (rank : 1140)
Query Neighborhood Hits	1044	Target Neighborhood Hits	576	Shared Neighborhood Hits	194
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

CEP63_HUMAN
θ value	θ > 10 (rank : 1108)	NC score	0.080516 (rank : 961)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1005	Shared Neighborhood Hits	221
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CEP70_HUMAN
θ value	θ > 10 (rank : 1109)	NC score	0.067895 (rank : 1108)
Query Neighborhood Hits	1044	Target Neighborhood Hits	432	Shared Neighborhood Hits	160
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

CEP70_MOUSE
θ value	θ > 10 (rank : 1110)	NC score	0.067977 (rank : 1106)
Query Neighborhood Hits	1044	Target Neighborhood Hits	532	Shared Neighborhood Hits	177
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

CF152_HUMAN
θ value	θ > 10 (rank : 1111)	NC score	0.072463 (rank : 1060)
Query Neighborhood Hits	1044	Target Neighborhood Hits	704	Shared Neighborhood Hits	201
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CF152_MOUSE
θ value	θ > 10 (rank : 1112)	NC score	0.060943 (rank : 1192)
Query Neighborhood Hits	1044	Target Neighborhood Hits	597	Shared Neighborhood Hits	177
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

CF182_HUMAN
θ value	θ > 10 (rank : 1113)	NC score	0.061069 (rank : 1189)
Query Neighborhood Hits	1044	Target Neighborhood Hits	474	Shared Neighborhood Hits	166
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

CF182_MOUSE
θ value	θ > 10 (rank : 1114)	NC score	0.072034 (rank : 1065)
Query Neighborhood Hits	1044	Target Neighborhood Hits	551	Shared Neighborhood Hits	185
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

CHCH3_MOUSE
θ value	θ > 10 (rank : 1115)	NC score	0.050353 (rank : 1350)
Query Neighborhood Hits	1044	Target Neighborhood Hits	249	Shared Neighborhood Hits	108
SwissProt Accessions	Q9CRB9	Gene names	Chchd3
Domain Architecture	No domain graphic available
Description	Coiled-coil-helix-coiled-coil-helix domain-containing protein 3.

CHIN_HUMAN
θ value	θ > 10 (rank : 1116)	NC score	0.072439 (rank : 1061)
Query Neighborhood Hits	1044	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1117)	NC score	0.073621 (rank : 1047)
Query Neighborhood Hits	1044	Target Neighborhood Hits	229	Shared Neighborhood Hits	65
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1118)	NC score	0.073806 (rank : 1044)
Query Neighborhood Hits	1044	Target Neighborhood Hits	220	Shared Neighborhood Hits	62
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 1119)	NC score	0.063402 (rank : 1153)
Query Neighborhood Hits	1044	Target Neighborhood Hits	130	Shared Neighborhood Hits	37
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CI039_HUMAN
θ value	θ > 10 (rank : 1120)	NC score	0.081862 (rank : 936)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1171	Shared Neighborhood Hits	231
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CI093_HUMAN
θ value	θ > 10 (rank : 1121)	NC score	0.082642 (rank : 926)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1088	Shared Neighborhood Hits	220
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CIP4_HUMAN
θ value	θ > 10 (rank : 1122)	NC score	0.074068 (rank : 1041)
Query Neighborhood Hits	1044	Target Neighborhood Hits	374	Shared Neighborhood Hits	144
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CK5P2_HUMAN
θ value	θ > 10 (rank : 1123)	NC score	0.071316 (rank : 1075)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1433	Shared Neighborhood Hits	245
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CK5P2_MOUSE
θ value	θ > 10 (rank : 1124)	NC score	0.072886 (rank : 1057)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1151	Shared Neighborhood Hits	230
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

CKAP4_HUMAN
θ value	θ > 10 (rank : 1125)	NC score	0.057646 (rank : 1247)
Query Neighborhood Hits	1044	Target Neighborhood Hits	592	Shared Neighborhood Hits	161
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CKAP4_MOUSE
θ value	θ > 10 (rank : 1126)	NC score	0.059436 (rank : 1222)
Query Neighborhood Hits	1044	Target Neighborhood Hits	596	Shared Neighborhood Hits	162
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CN145_MOUSE
θ value	θ > 10 (rank : 1127)	NC score	0.067264 (rank : 1111)
Query Neighborhood Hits	1044	Target Neighborhood Hits	916	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

CNTRB_HUMAN
θ value	θ > 10 (rank : 1128)	NC score	0.065411 (rank : 1128)
Query Neighborhood Hits	1044	Target Neighborhood Hits	690	Shared Neighborhood Hits	179
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CNTRB_MOUSE
θ value	θ > 10 (rank : 1129)	NC score	0.077004 (rank : 1009)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1029	Shared Neighborhood Hits	226
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP250_HUMAN
θ value	θ > 10 (rank : 1130)	NC score	0.080830 (rank : 959)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1805	Shared Neighborhood Hits	264
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CR034_HUMAN
θ value	θ > 10 (rank : 1131)	NC score	0.063083 (rank : 1161)
Query Neighborhood Hits	1044	Target Neighborhood Hits	538	Shared Neighborhood Hits	159
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

CRCM_HUMAN
θ value	θ > 10 (rank : 1132)	NC score	0.056084 (rank : 1277)
Query Neighborhood Hits	1044	Target Neighborhood Hits	520	Shared Neighborhood Hits	157
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

CRKL_HUMAN
θ value	θ > 10 (rank : 1133)	NC score	0.063228 (rank : 1159)
Query Neighborhood Hits	1044	Target Neighborhood Hits	313	Shared Neighborhood Hits	52
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 1134)	NC score	0.064530 (rank : 1136)
Query Neighborhood Hits	1044	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 1135)	NC score	0.053896 (rank : 1309)
Query Neighborhood Hits	1044	Target Neighborhood Hits	308	Shared Neighborhood Hits	53
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 1136)	NC score	0.052561 (rank : 1327)
Query Neighborhood Hits	1044	Target Neighborhood Hits	314	Shared Neighborhood Hits	53
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT096_HUMAN
θ value	θ > 10 (rank : 1137)	NC score	0.055760 (rank : 1280)
Query Neighborhood Hits	1044	Target Neighborhood Hits	438	Shared Neighborhood Hits	153
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

CTGE2_HUMAN
θ value	θ > 10 (rank : 1138)	NC score	0.054331 (rank : 1300)
Query Neighborhood Hits	1044	Target Neighborhood Hits	594	Shared Neighborhood Hits	167
SwissProt Accessions	Q96RT6	Gene names	CTAGE1, CTAGE2
Domain Architecture	No domain graphic available
Description	Protein cTAGE-2.

CTGE5_MOUSE
θ value	θ > 10 (rank : 1139)	NC score	0.055623 (rank : 1283)
Query Neighborhood Hits	1044	Target Neighborhood Hits	928	Shared Neighborhood Hits	205
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

CTGE6_HUMAN
θ value	θ > 10 (rank : 1140)	NC score	0.053189 (rank : 1321)
Query Neighborhood Hits	1044	Target Neighborhood Hits	650	Shared Neighborhood Hits	168
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

CU013_HUMAN
θ value	θ > 10 (rank : 1141)	NC score	0.051741 (rank : 1337)
Query Neighborhood Hits	1044	Target Neighborhood Hits	405	Shared Neighborhood Hits	135
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

CUTL1_HUMAN
θ value	θ > 10 (rank : 1142)	NC score	0.056791 (rank : 1267)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1574	Shared Neighborhood Hits	241
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

CUTL1_MOUSE
θ value	θ > 10 (rank : 1143)	NC score	0.057529 (rank : 1250)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1620	Shared Neighborhood Hits	243
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CYLN2_HUMAN
θ value	θ > 10 (rank : 1144)	NC score	0.078704 (rank : 991)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1004	Shared Neighborhood Hits	233
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CYLN2_MOUSE
θ value	θ > 10 (rank : 1145)	NC score	0.077022 (rank : 1008)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1002	Shared Neighborhood Hits	231
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

CYTSA_HUMAN
θ value	θ > 10 (rank : 1146)	NC score	0.059469 (rank : 1220)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1138	Shared Neighborhood Hits	226
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
θ value	θ > 10 (rank : 1147)	NC score	0.060076 (rank : 1207)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1104	Shared Neighborhood Hits	223
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

DAPP1_HUMAN
θ value	θ > 10 (rank : 1148)	NC score	0.070786 (rank : 1084)
Query Neighborhood Hits	1044	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 1149)	NC score	0.069688 (rank : 1092)
Query Neighborhood Hits	1044	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCX_HUMAN
θ value	θ > 10 (rank : 1150)	NC score	0.065469 (rank : 1126)
Query Neighborhood Hits	1044	Target Neighborhood Hits	141	Shared Neighborhood Hits	19
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCX_MOUSE
θ value	θ > 10 (rank : 1151)	NC score	0.062442 (rank : 1170)
Query Neighborhood Hits	1044	Target Neighborhood Hits	124	Shared Neighborhood Hits	12
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DESP_HUMAN
θ value	θ > 10 (rank : 1152)	NC score	0.078777 (rank : 989)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1470	Shared Neighborhood Hits	260
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

DGKB_HUMAN
θ value	θ > 10 (rank : 1153)	NC score	0.050490 (rank : 1346)
Query Neighborhood Hits	1044	Target Neighborhood Hits	238	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKD_HUMAN
θ value	θ > 10 (rank : 1154)	NC score	0.079087 (rank : 985)
Query Neighborhood Hits	1044	Target Neighborhood Hits	231	Shared Neighborhood Hits	82
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1155)	NC score	0.071252 (rank : 1076)
Query Neighborhood Hits	1044	Target Neighborhood Hits	255	Shared Neighborhood Hits	69
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1156)	NC score	0.062874 (rank : 1164)
Query Neighborhood Hits	1044	Target Neighborhood Hits	131	Shared Neighborhood Hits	35
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

DLG5_HUMAN
θ value	θ > 10 (rank : 1157)	NC score	0.057437 (rank : 1252)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1088	Shared Neighborhood Hits	212
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DMD_HUMAN
θ value	θ > 10 (rank : 1158)	NC score	0.054524 (rank : 1299)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1135	Shared Neighborhood Hits	222
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	θ > 10 (rank : 1159)	NC score	0.057032 (rank : 1264)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1111	Shared Neighborhood Hits	219
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DYNA_HUMAN
θ value	θ > 10 (rank : 1160)	NC score	0.055310 (rank : 1288)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1194	Shared Neighborhood Hits	219
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	θ > 10 (rank : 1161)	NC score	0.055376 (rank : 1286)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1084	Shared Neighborhood Hits	215
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

EP15R_HUMAN
θ value	θ > 10 (rank : 1162)	NC score	0.060562 (rank : 1196)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1083	Shared Neighborhood Hits	220
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

EP15R_MOUSE
θ value	θ > 10 (rank : 1163)	NC score	0.057790 (rank : 1245)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1135	Shared Neighborhood Hits	215
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

ERBB3_HUMAN
θ value	θ > 10 (rank : 1164)	NC score	0.664666 (rank : 759)
Query Neighborhood Hits	1044	Target Neighborhood Hits	918	Shared Neighborhood Hits	725
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 1165)	NC score	0.669369 (rank : 754)
Query Neighborhood Hits	1044	Target Neighborhood Hits	898	Shared Neighborhood Hits	727
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

EVPL_MOUSE
θ value	θ > 10 (rank : 1166)	NC score	0.065256 (rank : 1129)
Query Neighborhood Hits	1044	Target Neighborhood Hits	952	Shared Neighborhood Hits	215
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

FGFR4_HUMAN
θ value	θ > 10 (rank : 1167)	NC score	0.675407 (rank : 741)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1037	Shared Neighborhood Hits	754
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 1168)	NC score	0.651507 (rank : 775)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1026	Shared Neighborhood Hits	743
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FYCO1_MOUSE
θ value	θ > 10 (rank : 1169)	NC score	0.061254 (rank : 1182)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1059	Shared Neighborhood Hits	215
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GAS8_HUMAN
θ value	θ > 10 (rank : 1170)	NC score	0.081850 (rank : 937)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	216
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GAS8_MOUSE
θ value	θ > 10 (rank : 1171)	NC score	0.079493 (rank : 974)
Query Neighborhood Hits	1044	Target Neighborhood Hits	622	Shared Neighborhood Hits	192
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GCC1_HUMAN
θ value	θ > 10 (rank : 1172)	NC score	0.066023 (rank : 1121)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	206
SwissProt Accessions	Q96CN9, Q9H6N7	Gene names	GCC1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

GCC1_MOUSE
θ value	θ > 10 (rank : 1173)	NC score	0.063271 (rank : 1158)
Query Neighborhood Hits	1044	Target Neighborhood Hits	777	Shared Neighborhood Hits	193
SwissProt Accessions	Q9D4H2, Q8CCR3	Gene names	Gcc1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

GCC2_HUMAN
θ value	θ > 10 (rank : 1174)	NC score	0.076263 (rank : 1017)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1558	Shared Neighborhood Hits	250
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

GCC2_MOUSE
θ value	θ > 10 (rank : 1175)	NC score	0.075746 (rank : 1026)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1619	Shared Neighborhood Hits	250
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GLE1_HUMAN
θ value	θ > 10 (rank : 1176)	NC score	0.057968 (rank : 1242)
Query Neighborhood Hits	1044	Target Neighborhood Hits	445	Shared Neighborhood Hits	157
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

GLE1_MOUSE
θ value	θ > 10 (rank : 1177)	NC score	0.056116 (rank : 1276)
Query Neighborhood Hits	1044	Target Neighborhood Hits	504	Shared Neighborhood Hits	158
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

GOGA1_MOUSE
θ value	θ > 10 (rank : 1178)	NC score	0.082076 (rank : 933)
Query Neighborhood Hits	1044	Target Neighborhood Hits	994	Shared Neighborhood Hits	225
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA2_HUMAN
θ value	θ > 10 (rank : 1179)	NC score	0.063987 (rank : 1142)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	193
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

GOGA2_MOUSE
θ value	θ > 10 (rank : 1180)	NC score	0.071783 (rank : 1068)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	204
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

GP73_MOUSE
θ value	θ > 10 (rank : 1181)	NC score	0.058704 (rank : 1233)
Query Neighborhood Hits	1044	Target Neighborhood Hits	506	Shared Neighborhood Hits	160
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

GRAP2_HUMAN
θ value	θ > 10 (rank : 1182)	NC score	0.093563 (rank : 867)
Query Neighborhood Hits	1044	Target Neighborhood Hits	304	Shared Neighborhood Hits	53
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1183)	NC score	0.092240 (rank : 874)
Query Neighborhood Hits	1044	Target Neighborhood Hits	297	Shared Neighborhood Hits	52
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1184)	NC score	0.095851 (rank : 860)
Query Neighborhood Hits	1044	Target Neighborhood Hits	307	Shared Neighborhood Hits	54
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1185)	NC score	0.095430 (rank : 863)
Query Neighborhood Hits	1044	Target Neighborhood Hits	309	Shared Neighborhood Hits	53
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB14_HUMAN
θ value	θ > 10 (rank : 1186)	NC score	0.053518 (rank : 1313)
Query Neighborhood Hits	1044	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 1187)	NC score	0.059167 (rank : 1226)
Query Neighborhood Hits	1044	Target Neighborhood Hits	149	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 1188)	NC score	0.093223 (rank : 870)
Query Neighborhood Hits	1044	Target Neighborhood Hits	310	Shared Neighborhood Hits	55
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1189)	NC score	0.093177 (rank : 871)
Query Neighborhood Hits	1044	Target Neighborhood Hits	312	Shared Neighborhood Hits	55
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 1190)	NC score	0.092750 (rank : 872)
Query Neighborhood Hits	1044	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GUC2D_HUMAN
θ value	θ > 10 (rank : 1191)	NC score	0.504636 (rank : 824)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	623
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2E_MOUSE
θ value	θ > 10 (rank : 1192)	NC score	0.486381 (rank : 827)
Query Neighborhood Hits	1044	Target Neighborhood Hits	692	Shared Neighborhood Hits	600
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2F_HUMAN
θ value	θ > 10 (rank : 1193)	NC score	0.557797 (rank : 816)
Query Neighborhood Hits	1044	Target Neighborhood Hits	740	Shared Neighborhood Hits	637
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

GUC2G_MOUSE
θ value	θ > 10 (rank : 1194)	NC score	0.487909 (rank : 826)
Query Neighborhood Hits	1044	Target Neighborhood Hits	644	Shared Neighborhood Hits	541
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

HAP1_HUMAN
θ value	θ > 10 (rank : 1195)	NC score	0.054588 (rank : 1298)
Query Neighborhood Hits	1044	Target Neighborhood Hits	606	Shared Neighborhood Hits	184
SwissProt Accessions	P54257, O75358, Q9H4G3, Q9HA98, Q9NY90	Gene names	HAP1, HLP1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1).

HIP1R_HUMAN
θ value	θ > 10 (rank : 1196)	NC score	0.056036 (rank : 1279)
Query Neighborhood Hits	1044	Target Neighborhood Hits	809	Shared Neighborhood Hits	200
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

HIP1R_MOUSE
θ value	θ > 10 (rank : 1197)	NC score	0.068859 (rank : 1100)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	217
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

HIP1_HUMAN
θ value	θ > 10 (rank : 1198)	NC score	0.071536 (rank : 1073)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1016	Shared Neighborhood Hits	227
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

HOME2_MOUSE
θ value	θ > 10 (rank : 1199)	NC score	0.058535 (rank : 1236)
Query Neighborhood Hits	1044	Target Neighborhood Hits	882	Shared Neighborhood Hits	215
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

HOOK1_MOUSE
θ value	θ > 10 (rank : 1200)	NC score	0.067081 (rank : 1113)
Query Neighborhood Hits	1044	Target Neighborhood Hits	910	Shared Neighborhood Hits	204
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

HOOK2_HUMAN
θ value	θ > 10 (rank : 1201)	NC score	0.062375 (rank : 1171)
Query Neighborhood Hits	1044	Target Neighborhood Hits	714	Shared Neighborhood Hits	191
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

HOOK2_MOUSE
θ value	θ > 10 (rank : 1202)	NC score	0.061582 (rank : 1178)
Query Neighborhood Hits	1044	Target Neighborhood Hits	736	Shared Neighborhood Hits	193
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

HOOK3_HUMAN
θ value	θ > 10 (rank : 1203)	NC score	0.063964 (rank : 1143)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1070	Shared Neighborhood Hits	218
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

HOOK3_MOUSE
θ value	θ > 10 (rank : 1204)	NC score	0.063135 (rank : 1160)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1007	Shared Neighborhood Hits	214
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

HSH2D_HUMAN
θ value	θ > 10 (rank : 1205)	NC score	0.062772 (rank : 1166)
Query Neighborhood Hits	1044	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IF2P_HUMAN
θ value	θ > 10 (rank : 1206)	NC score	0.056042 (rank : 1278)
Query Neighborhood Hits	1044	Target Neighborhood Hits	889	Shared Neighborhood Hits	170
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

IF3A_HUMAN
θ value	θ > 10 (rank : 1207)	NC score	0.070682 (rank : 1086)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	206
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IF3A_MOUSE
θ value	θ > 10 (rank : 1208)	NC score	0.071015 (rank : 1078)
Query Neighborhood Hits	1044	Target Neighborhood Hits	871	Shared Neighborhood Hits	204
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

IFT74_HUMAN
θ value	θ > 10 (rank : 1209)	NC score	0.072434 (rank : 1062)
Query Neighborhood Hits	1044	Target Neighborhood Hits	949	Shared Neighborhood Hits	209
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT74_MOUSE
θ value	θ > 10 (rank : 1210)	NC score	0.066571 (rank : 1117)
Query Neighborhood Hits	1044	Target Neighborhood Hits	939	Shared Neighborhood Hits	208
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT81_HUMAN
θ value	θ > 10 (rank : 1211)	NC score	0.079191 (rank : 982)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	214
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IFT81_MOUSE
θ value	θ > 10 (rank : 1212)	NC score	0.081095 (rank : 954)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	223
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

ILK1_HUMAN
θ value	θ > 10 (rank : 1213)	NC score	0.448000 (rank : 834)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	541
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 1214)	NC score	0.435336 (rank : 836)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	535
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 1215)	NC score	0.445824 (rank : 835)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	542
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

IMMT_HUMAN
θ value	θ > 10 (rank : 1216)	NC score	0.056750 (rank : 1268)
Query Neighborhood Hits	1044	Target Neighborhood Hits	494	Shared Neighborhood Hits	156
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

INSRR_HUMAN
θ value	θ > 10 (rank : 1217)	NC score	0.653288 (rank : 771)
Query Neighborhood Hits	1044	Target Neighborhood Hits	950	Shared Neighborhood Hits	730
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 1218)	NC score	0.655157 (rank : 769)
Query Neighborhood Hits	1044	Target Neighborhood Hits	961	Shared Neighborhood Hits	731
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 1219)	NC score	0.676915 (rank : 738)
Query Neighborhood Hits	1044	Target Neighborhood Hits	963	Shared Neighborhood Hits	757
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 1220)	NC score	0.673971 (rank : 745)
Query Neighborhood Hits	1044	Target Neighborhood Hits	968	Shared Neighborhood Hits	749
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INVO_MOUSE
θ value	θ > 10 (rank : 1221)	NC score	0.065946 (rank : 1122)
Query Neighborhood Hits	1044	Target Neighborhood Hits	474	Shared Neighborhood Hits	136
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

ITSN1_MOUSE
θ value	θ > 10 (rank : 1222)	NC score	0.083564 (rank : 917)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1669	Shared Neighborhood Hits	287
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

K0555_HUMAN
θ value	θ > 10 (rank : 1223)	NC score	0.088126 (rank : 886)
Query Neighborhood Hits	1044	Target Neighborhood Hits	880	Shared Neighborhood Hits	218
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

K0586_HUMAN
θ value	θ > 10 (rank : 1224)	NC score	0.052065 (rank : 1333)
Query Neighborhood Hits	1044	Target Neighborhood Hits	311	Shared Neighborhood Hits	104
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

K2002_MOUSE
θ value	θ > 10 (rank : 1225)	NC score	0.268217 (rank : 846)
Query Neighborhood Hits	1044	Target Neighborhood Hits	267	Shared Neighborhood Hits	226
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KMHN1_HUMAN
θ value	θ > 10 (rank : 1226)	NC score	0.073431 (rank : 1054)
Query Neighborhood Hits	1044	Target Neighborhood Hits	950	Shared Neighborhood Hits	220
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

KNTC2_HUMAN
θ value	θ > 10 (rank : 1227)	NC score	0.059003 (rank : 1229)
Query Neighborhood Hits	1044	Target Neighborhood Hits	673	Shared Neighborhood Hits	178
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

KNTC2_MOUSE
θ value	θ > 10 (rank : 1228)	NC score	0.059906 (rank : 1211)
Query Neighborhood Hits	1044	Target Neighborhood Hits	692	Shared Neighborhood Hits	171
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

KTN1_HUMAN
θ value	θ > 10 (rank : 1229)	NC score	0.066480 (rank : 1118)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1197	Shared Neighborhood Hits	220
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

LIMK2_HUMAN
θ value	θ > 10 (rank : 1230)	NC score	0.804385 (rank : 556)
Query Neighborhood Hits	1044	Target Neighborhood Hits	986	Shared Neighborhood Hits	763
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIMK2_MOUSE
θ value	θ > 10 (rank : 1231)	NC score	0.801572 (rank : 558)
Query Neighborhood Hits	1044	Target Neighborhood Hits	998	Shared Neighborhood Hits	764
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LIPA2_MOUSE
θ value	θ > 10 (rank : 1232)	NC score	0.067405 (rank : 1110)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1282	Shared Neighborhood Hits	238
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LIPA3_HUMAN
θ value	θ > 10 (rank : 1233)	NC score	0.050211 (rank : 1351)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	196
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPB1_MOUSE
θ value	θ > 10 (rank : 1234)	NC score	0.054979 (rank : 1292)
Query Neighborhood Hits	1044	Target Neighborhood Hits	727	Shared Neighborhood Hits	190
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

LRC45_HUMAN
θ value	θ > 10 (rank : 1235)	NC score	0.071913 (rank : 1067)
Query Neighborhood Hits	1044	Target Neighborhood Hits	933	Shared Neighborhood Hits	221
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRRF2_HUMAN
θ value	θ > 10 (rank : 1236)	NC score	0.061241 (rank : 1183)
Query Neighborhood Hits	1044	Target Neighborhood Hits	791	Shared Neighborhood Hits	196
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LRRF2_MOUSE
θ value	θ > 10 (rank : 1237)	NC score	0.062458 (rank : 1169)
Query Neighborhood Hits	1044	Target Neighborhood Hits	556	Shared Neighborhood Hits	175
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LRRK1_HUMAN
θ value	θ > 10 (rank : 1238)	NC score	0.746840 (rank : 621)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1237	Shared Neighborhood Hits	752
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LRRK1_MOUSE
θ value	θ > 10 (rank : 1239)	NC score	0.744915 (rank : 625)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1267	Shared Neighborhood Hits	756
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LUZP1_HUMAN
θ value	θ > 10 (rank : 1240)	NC score	0.066244 (rank : 1120)
Query Neighborhood Hits	1044	Target Neighborhood Hits	739	Shared Neighborhood Hits	183
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

LZTS1_HUMAN
θ value	θ > 10 (rank : 1241)	NC score	0.050374 (rank : 1349)
Query Neighborhood Hits	1044	Target Neighborhood Hits	532	Shared Neighborhood Hits	152
SwissProt Accessions	Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2	Gene names	LZTS1, FEZ1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

LZTS1_MOUSE
θ value	θ > 10 (rank : 1242)	NC score	0.053714 (rank : 1311)
Query Neighborhood Hits	1044	Target Neighborhood Hits	540	Shared Neighborhood Hits	164
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

MACF1_HUMAN
θ value	θ > 10 (rank : 1243)	NC score	0.053492 (rank : 1314)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1341	Shared Neighborhood Hits	224
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MACF1_MOUSE
θ value	θ > 10 (rank : 1244)	NC score	0.052140 (rank : 1332)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1313	Shared Neighborhood Hits	229
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MACF4_HUMAN
θ value	θ > 10 (rank : 1245)	NC score	0.060455 (rank : 1199)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1321	Shared Neighborhood Hits	221
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MACOI_HUMAN
θ value	θ > 10 (rank : 1246)	NC score	0.059221 (rank : 1225)
Query Neighborhood Hits	1044	Target Neighborhood Hits	650	Shared Neighborhood Hits	185
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MACOI_MOUSE
θ value	θ > 10 (rank : 1247)	NC score	0.060498 (rank : 1198)
Query Neighborhood Hits	1044	Target Neighborhood Hits	620	Shared Neighborhood Hits	180
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MD1L1_HUMAN
θ value	θ > 10 (rank : 1248)	NC score	0.079638 (rank : 971)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	211
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MD1L1_MOUSE
θ value	θ > 10 (rank : 1249)	NC score	0.081245 (rank : 952)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1001	Shared Neighborhood Hits	219
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MERTK_HUMAN
θ value	θ > 10 (rank : 1250)	NC score	0.648902 (rank : 778)
Query Neighborhood Hits	1044	Target Neighborhood Hits	988	Shared Neighborhood Hits	720
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 1251)	NC score	0.655163 (rank : 768)
Query Neighborhood Hits	1044	Target Neighborhood Hits	974	Shared Neighborhood Hits	713
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MFAP1_HUMAN
θ value	θ > 10 (rank : 1252)	NC score	0.050098 (rank : 1352)
Query Neighborhood Hits	1044	Target Neighborhood Hits	321	Shared Neighborhood Hits	113
SwissProt Accessions	P55081	Gene names	MFAP1
Domain Architecture
Description	Microfibrillar-associated protein 1.

MFAP1_MOUSE
θ value	θ > 10 (rank : 1253)	NC score	0.057257 (rank : 1255)
Query Neighborhood Hits	1044	Target Neighborhood Hits	353	Shared Neighborhood Hits	120
SwissProt Accessions	Q9CQU1, Q3TU29, Q8CCL1, Q9CSJ5	Gene names	Mfap1
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 1.

MIPO1_HUMAN
θ value	θ > 10 (rank : 1254)	NC score	0.057437 (rank : 1251)
Query Neighborhood Hits	1044	Target Neighborhood Hits	486	Shared Neighborhood Hits	165
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

MMRN1_HUMAN
θ value	θ > 10 (rank : 1255)	NC score	0.053418 (rank : 1316)
Query Neighborhood Hits	1044	Target Neighborhood Hits	636	Shared Neighborhood Hits	144
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

MPP9_HUMAN
θ value	θ > 10 (rank : 1256)	NC score	0.067006 (rank : 1114)
Query Neighborhood Hits	1044	Target Neighborhood Hits	529	Shared Neighborhood Hits	167
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

MY18B_HUMAN
θ value	θ > 10 (rank : 1257)	NC score	0.079466 (rank : 976)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1299	Shared Neighborhood Hits	232
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYH3_HUMAN
θ value	θ > 10 (rank : 1258)	NC score	0.084689 (rank : 912)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1660	Shared Neighborhood Hits	247
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYO15_MOUSE
θ value	θ > 10 (rank : 1259)	NC score	0.050481 (rank : 1347)
Query Neighborhood Hits	1044	Target Neighborhood Hits	467	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO1E_HUMAN
θ value	θ > 10 (rank : 1260)	NC score	0.058514 (rank : 1237)
Query Neighborhood Hits	1044	Target Neighborhood Hits	293	Shared Neighborhood Hits	65
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 1261)	NC score	0.058281 (rank : 1241)
Query Neighborhood Hits	1044	Target Neighborhood Hits	275	Shared Neighborhood Hits	66
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 1262)	NC score	0.057615 (rank : 1248)
Query Neighborhood Hits	1044	Target Neighborhood Hits	262	Shared Neighborhood Hits	64
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO5B_HUMAN
θ value	θ > 10 (rank : 1263)	NC score	0.072003 (rank : 1066)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	212
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

MYO5C_HUMAN
θ value	θ > 10 (rank : 1264)	NC score	0.079710 (rank : 968)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1206	Shared Neighborhood Hits	236
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

MYO6_HUMAN
θ value	θ > 10 (rank : 1265)	NC score	0.068492 (rank : 1101)
Query Neighborhood Hits	1044	Target Neighborhood Hits	727	Shared Neighborhood Hits	181
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO6_MOUSE
θ value	θ > 10 (rank : 1266)	NC score	0.067247 (rank : 1112)
Query Neighborhood Hits	1044	Target Neighborhood Hits	586	Shared Neighborhood Hits	165
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO7A_HUMAN
θ value	θ > 10 (rank : 1267)	NC score	0.051148 (rank : 1343)
Query Neighborhood Hits	1044	Target Neighborhood Hits	209	Shared Neighborhood Hits	68
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO7A_MOUSE
θ value	θ > 10 (rank : 1268)	NC score	0.051844 (rank : 1335)
Query Neighborhood Hits	1044	Target Neighborhood Hits	235	Shared Neighborhood Hits	76
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO9B_HUMAN
θ value	θ > 10 (rank : 1269)	NC score	0.060192 (rank : 1203)
Query Neighborhood Hits	1044	Target Neighborhood Hits	641	Shared Neighborhood Hits	106
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_MOUSE
θ value	θ > 10 (rank : 1270)	NC score	0.060280 (rank : 1202)
Query Neighborhood Hits	1044	Target Neighborhood Hits	311	Shared Neighborhood Hits	75
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYOM1_HUMAN
θ value	θ > 10 (rank : 1271)	NC score	0.056245 (rank : 1273)
Query Neighborhood Hits	1044	Target Neighborhood Hits	405	Shared Neighborhood Hits	77
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM1_MOUSE
θ value	θ > 10 (rank : 1272)	NC score	0.054165 (rank : 1305)
Query Neighborhood Hits	1044	Target Neighborhood Hits	415	Shared Neighborhood Hits	73
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MYOM2_HUMAN
θ value	θ > 10 (rank : 1273)	NC score	0.052217 (rank : 1331)
Query Neighborhood Hits	1044	Target Neighborhood Hits	341	Shared Neighborhood Hits	61
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYPC3_MOUSE
θ value	θ > 10 (rank : 1274)	NC score	0.053223 (rank : 1319)
Query Neighborhood Hits	1044	Target Neighborhood Hits	310	Shared Neighborhood Hits	56
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

NAF1_HUMAN
θ value	θ > 10 (rank : 1275)	NC score	0.073075 (rank : 1055)
Query Neighborhood Hits	1044	Target Neighborhood Hits	937	Shared Neighborhood Hits	217
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NCK1_HUMAN
θ value	θ > 10 (rank : 1276)	NC score	0.090698 (rank : 878)
Query Neighborhood Hits	1044	Target Neighborhood Hits	312	Shared Neighborhood Hits	55
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 1277)	NC score	0.090113 (rank : 880)
Query Neighborhood Hits	1044	Target Neighborhood Hits	310	Shared Neighborhood Hits	53
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NDE1_MOUSE
θ value	θ > 10 (rank : 1278)	NC score	0.057136 (rank : 1259)
Query Neighborhood Hits	1044	Target Neighborhood Hits	602	Shared Neighborhood Hits	180
SwissProt Accessions	Q9CZA6, Q3UBS6, Q3UIC1, Q9ERR0	Gene names	Nde1, Nude
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE) (mNudE).

NEMO_HUMAN
θ value	θ > 10 (rank : 1279)	NC score	0.074227 (rank : 1037)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NEMO_MOUSE
θ value	θ > 10 (rank : 1280)	NC score	0.067952 (rank : 1107)
Query Neighborhood Hits	1044	Target Neighborhood Hits	658	Shared Neighborhood Hits	187
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

NEO1_HUMAN
θ value	θ > 10 (rank : 1281)	NC score	0.050449 (rank : 1348)
Query Neighborhood Hits	1044	Target Neighborhood Hits	530	Shared Neighborhood Hits	72
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	θ > 10 (rank : 1282)	NC score	0.050979 (rank : 1344)
Query Neighborhood Hits	1044	Target Neighborhood Hits	523	Shared Neighborhood Hits	75
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NEST_HUMAN
θ value	θ > 10 (rank : 1283)	NC score	0.063772 (rank : 1147)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1305	Shared Neighborhood Hits	227
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NPHP1_HUMAN
θ value	θ > 10 (rank : 1284)	NC score	0.051670 (rank : 1339)
Query Neighborhood Hits	1044	Target Neighborhood Hits	288	Shared Neighborhood Hits	77
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 1285)	NC score	0.059875 (rank : 1212)
Query Neighborhood Hits	1044	Target Neighborhood Hits	267	Shared Neighborhood Hits	67
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NTKL_HUMAN
θ value	θ > 10 (rank : 1286)	NC score	0.274778 (rank : 845)
Query Neighborhood Hits	1044	Target Neighborhood Hits	266	Shared Neighborhood Hits	209
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

NTKL_MOUSE
θ value	θ > 10 (rank : 1287)	NC score	0.358719 (rank : 841)
Query Neighborhood Hits	1044	Target Neighborhood Hits	326	Shared Neighborhood Hits	274
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

NUF2_HUMAN
θ value	θ > 10 (rank : 1288)	NC score	0.063880 (rank : 1144)
Query Neighborhood Hits	1044	Target Neighborhood Hits	661	Shared Neighborhood Hits	176
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

NUF2_MOUSE
θ value	θ > 10 (rank : 1289)	NC score	0.055272 (rank : 1289)
Query Neighborhood Hits	1044	Target Neighborhood Hits	585	Shared Neighborhood Hits	173
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

OFD1_HUMAN
θ value	θ > 10 (rank : 1290)	NC score	0.068414 (rank : 1103)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	194
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

OPTN_HUMAN
θ value	θ > 10 (rank : 1291)	NC score	0.061172 (rank : 1184)
Query Neighborhood Hits	1044	Target Neighborhood Hits	827	Shared Neighborhood Hits	201
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

OPTN_MOUSE
θ value	θ > 10 (rank : 1292)	NC score	0.074653 (rank : 1035)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1120	Shared Neighborhood Hits	235
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

P55G_HUMAN
θ value	θ > 10 (rank : 1293)	NC score	0.077207 (rank : 1005)
Query Neighborhood Hits	1044	Target Neighborhood Hits	451	Shared Neighborhood Hits	171
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 1294)	NC score	0.075425 (rank : 1031)
Query Neighborhood Hits	1044	Target Neighborhood Hits	401	Shared Neighborhood Hits	154
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 1295)	NC score	0.056211 (rank : 1275)
Query Neighborhood Hits	1044	Target Neighborhood Hits	479	Shared Neighborhood Hits	138
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 1296)	NC score	0.052596 (rank : 1326)
Query Neighborhood Hits	1044	Target Neighborhood Hits	435	Shared Neighborhood Hits	114
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 1297)	NC score	0.078460 (rank : 996)
Query Neighborhood Hits	1044	Target Neighborhood Hits	543	Shared Neighborhood Hits	182
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 1298)	NC score	0.080373 (rank : 964)
Query Neighborhood Hits	1044	Target Neighborhood Hits	519	Shared Neighborhood Hits	182
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACE1_HUMAN
θ value	θ > 10 (rank : 1299)	NC score	0.061390 (rank : 1179)
Query Neighborhood Hits	1044	Target Neighborhood Hits	74	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PACE1_MOUSE
θ value	θ > 10 (rank : 1300)	NC score	0.064360 (rank : 1139)
Query Neighborhood Hits	1044	Target Neighborhood Hits	92	Shared Neighborhood Hits	53
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PDZD8_HUMAN
θ value	θ > 10 (rank : 1301)	NC score	0.073505 (rank : 1050)
Query Neighborhood Hits	1044	Target Neighborhood Hits	185	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PEPL_MOUSE
θ value	θ > 10 (rank : 1302)	NC score	0.074270 (rank : 1036)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1105	Shared Neighborhood Hits	228
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PGFRA_HUMAN
θ value	θ > 10 (rank : 1303)	NC score	0.634019 (rank : 782)
Query Neighborhood Hits	1044	Target Neighborhood Hits	980	Shared Neighborhood Hits	741
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 1304)	NC score	0.632362 (rank : 784)
Query Neighborhood Hits	1044	Target Neighborhood Hits	975	Shared Neighborhood Hits	739
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 1305)	NC score	0.626590 (rank : 790)
Query Neighborhood Hits	1044	Target Neighborhood Hits	962	Shared Neighborhood Hits	739
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 1306)	NC score	0.625519 (rank : 792)
Query Neighborhood Hits	1044	Target Neighborhood Hits	960	Shared Neighborhood Hits	741
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PHLB1_HUMAN
θ value	θ > 10 (rank : 1307)	NC score	0.056263 (rank : 1272)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1038	Shared Neighborhood Hits	217
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB3_HUMAN
θ value	θ > 10 (rank : 1308)	NC score	0.054716 (rank : 1295)
Query Neighborhood Hits	1044	Target Neighborhood Hits	304	Shared Neighborhood Hits	106
SwissProt Accessions	Q6NSJ2, Q8N7Z4	Gene names	PHLDB3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 3.

PI3R4_HUMAN
θ value	θ > 10 (rank : 1309)	NC score	0.361606 (rank : 840)
Query Neighborhood Hits	1044	Target Neighborhood Hits	534	Shared Neighborhood Hits	345
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	θ > 10 (rank : 1310)	NC score	0.374374 (rank : 838)
Query Neighborhood Hits	1044	Target Neighborhood Hits	535	Shared Neighborhood Hits	343
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PIBF1_HUMAN
θ value	θ > 10 (rank : 1311)	NC score	0.090747 (rank : 877)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1041	Shared Neighborhood Hits	232
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

PININ_HUMAN
θ value	θ > 10 (rank : 1312)	NC score	0.063839 (rank : 1146)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	182
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PININ_MOUSE
θ value	θ > 10 (rank : 1313)	NC score	0.063337 (rank : 1155)
Query Neighborhood Hits	1044	Target Neighborhood Hits	777	Shared Neighborhood Hits	182
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PLCG1_HUMAN
θ value	θ > 10 (rank : 1314)	NC score	0.062262 (rank : 1173)
Query Neighborhood Hits	1044	Target Neighborhood Hits	293	Shared Neighborhood Hits	61
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 1315)	NC score	0.062875 (rank : 1163)
Query Neighborhood Hits	1044	Target Neighborhood Hits	314	Shared Neighborhood Hits	64
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 1316)	NC score	0.059542 (rank : 1218)
Query Neighborhood Hits	1044	Target Neighborhood Hits	280	Shared Neighborhood Hits	53
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLVAP_HUMAN
θ value	θ > 10 (rank : 1317)	NC score	0.051719 (rank : 1338)
Query Neighborhood Hits	1044	Target Neighborhood Hits	397	Shared Neighborhood Hits	148
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

PMYT1_HUMAN
θ value	θ > 10 (rank : 1318)	NC score	0.860300 (rank : 456)
Query Neighborhood Hits	1044	Target Neighborhood Hits	814	Shared Neighborhood Hits	750
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

POF1B_HUMAN
θ value	θ > 10 (rank : 1319)	NC score	0.059809 (rank : 1214)
Query Neighborhood Hits	1044	Target Neighborhood Hits	494	Shared Neighborhood Hits	156
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

POF1B_MOUSE
θ value	θ > 10 (rank : 1320)	NC score	0.058600 (rank : 1234)
Query Neighborhood Hits	1044	Target Neighborhood Hits	530	Shared Neighborhood Hits	160
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

PRC1_HUMAN
θ value	θ > 10 (rank : 1321)	NC score	0.050516 (rank : 1345)
Query Neighborhood Hits	1044	Target Neighborhood Hits	328	Shared Neighborhood Hits	132
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

PRPK_HUMAN
θ value	θ > 10 (rank : 1322)	NC score	0.146034 (rank : 852)
Query Neighborhood Hits	1044	Target Neighborhood Hits	131	Shared Neighborhood Hits	122
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 1323)	NC score	0.154354 (rank : 851)
Query Neighborhood Hits	1044	Target Neighborhood Hits	139	Shared Neighborhood Hits	127
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PXK_HUMAN
θ value	θ > 10 (rank : 1324)	NC score	0.137338 (rank : 853)
Query Neighborhood Hits	1044	Target Neighborhood Hits	216	Shared Neighborhood Hits	129
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 1325)	NC score	0.184124 (rank : 849)
Query Neighborhood Hits	1044	Target Neighborhood Hits	320	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RABE1_HUMAN
θ value	θ > 10 (rank : 1326)	NC score	0.075452 (rank : 1030)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1104	Shared Neighborhood Hits	224
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	θ > 10 (rank : 1327)	NC score	0.076408 (rank : 1015)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1105	Shared Neighborhood Hits	225
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

RABE2_HUMAN
θ value	θ > 10 (rank : 1328)	NC score	0.054863 (rank : 1294)
Query Neighborhood Hits	1044	Target Neighborhood Hits	545	Shared Neighborhood Hits	169
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RABE2_MOUSE
θ value	θ > 10 (rank : 1329)	NC score	0.058712 (rank : 1232)
Query Neighborhood Hits	1044	Target Neighborhood Hits	598	Shared Neighborhood Hits	177
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RAI14_MOUSE
θ value	θ > 10 (rank : 1330)	NC score	0.059820 (rank : 1213)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1505	Shared Neighborhood Hits	229
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RASA1_HUMAN
θ value	θ > 10 (rank : 1331)	NC score	0.079469 (rank : 975)
Query Neighborhood Hits	1044	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_HUMAN
θ value	θ > 10 (rank : 1332)	NC score	0.061588 (rank : 1177)
Query Neighborhood Hits	1044	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 1333)	NC score	0.074171 (rank : 1038)
Query Neighborhood Hits	1044	Target Neighborhood Hits	74	Shared Neighborhood Hits	32
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RBBP8_HUMAN
θ value	θ > 10 (rank : 1334)	NC score	0.056941 (rank : 1265)
Query Neighborhood Hits	1044	Target Neighborhood Hits	476	Shared Neighborhood Hits	169
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

RBCC1_HUMAN
θ value	θ > 10 (rank : 1335)	NC score	0.071648 (rank : 1071)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1023	Shared Neighborhood Hits	222
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

RBCC1_MOUSE
θ value	θ > 10 (rank : 1336)	NC score	0.070896 (rank : 1080)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1048	Shared Neighborhood Hits	220
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RBM25_HUMAN
θ value	θ > 10 (rank : 1337)	NC score	0.076740 (rank : 1011)
Query Neighborhood Hits	1044	Target Neighborhood Hits	682	Shared Neighborhood Hits	155
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

RBP24_HUMAN
θ value	θ > 10 (rank : 1338)	NC score	0.076475 (rank : 1014)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1559	Shared Neighborhood Hits	251
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RFIP3_HUMAN
θ value	θ > 10 (rank : 1339)	NC score	0.065248 (rank : 1130)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1055	Shared Neighborhood Hits	220
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RFIP4_HUMAN
θ value	θ > 10 (rank : 1340)	NC score	0.061074 (rank : 1188)
Query Neighborhood Hits	1044	Target Neighborhood Hits	785	Shared Neighborhood Hits	197
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RGNEF_MOUSE
θ value	θ > 10 (rank : 1341)	NC score	0.063329 (rank : 1156)
Query Neighborhood Hits	1044	Target Neighborhood Hits	641	Shared Neighborhood Hits	197
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RIMB1_HUMAN
θ value	θ > 10 (rank : 1342)	NC score	0.068398 (rank : 1104)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1479	Shared Neighborhood Hits	261
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 1343)	NC score	0.077672 (rank : 999)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1376	Shared Neighborhood Hits	260
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RN5A_HUMAN
θ value	θ > 10 (rank : 1344)	NC score	0.159409 (rank : 850)
Query Neighborhood Hits	1044	Target Neighborhood Hits	608	Shared Neighborhood Hits	322
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RN5A_MOUSE
θ value	θ > 10 (rank : 1345)	NC score	0.338082 (rank : 842)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	584
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RPGR1_HUMAN
θ value	θ > 10 (rank : 1346)	NC score	0.054077 (rank : 1307)
Query Neighborhood Hits	1044	Target Neighborhood Hits	578	Shared Neighborhood Hits	158
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

RPKL1_HUMAN
θ value	θ > 10 (rank : 1347)	NC score	0.717502 (rank : 671)
Query Neighborhood Hits	1044	Target Neighborhood Hits	708	Shared Neighborhood Hits	630
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 1348)	NC score	0.718006 (rank : 670)
Query Neighborhood Hits	1044	Target Neighborhood Hits	704	Shared Neighborhood Hits	626
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RRBP1_MOUSE
θ value	θ > 10 (rank : 1349)	NC score	0.060083 (rank : 1206)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1650	Shared Neighborhood Hits	249
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

RUFY1_MOUSE
θ value	θ > 10 (rank : 1350)	NC score	0.055053 (rank : 1291)
Query Neighborhood Hits	1044	Target Neighborhood Hits	765	Shared Neighborhood Hits	176
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY3_HUMAN
θ value	θ > 10 (rank : 1351)	NC score	0.057090 (rank : 1262)
Query Neighborhood Hits	1044	Target Neighborhood Hits	594	Shared Neighborhood Hits	180
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 1352)	NC score	0.056609 (rank : 1270)
Query Neighborhood Hits	1044	Target Neighborhood Hits	579	Shared Neighborhood Hits	180
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RYK_HUMAN
θ value	θ > 10 (rank : 1353)	NC score	0.572379 (rank : 815)
Query Neighborhood Hits	1044	Target Neighborhood Hits	701	Shared Neighborhood Hits	646
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 1354)	NC score	0.588038 (rank : 813)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	658
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SAS6_HUMAN
θ value	θ > 10 (rank : 1355)	NC score	0.063575 (rank : 1150)
Query Neighborhood Hits	1044	Target Neighborhood Hits	791	Shared Neighborhood Hits	187
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

SAS6_MOUSE
θ value	θ > 10 (rank : 1356)	NC score	0.069903 (rank : 1090)
Query Neighborhood Hits	1044	Target Neighborhood Hits	931	Shared Neighborhood Hits	208
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

SCYL2_HUMAN
θ value	θ > 10 (rank : 1357)	NC score	0.615108 (rank : 803)
Query Neighborhood Hits	1044	Target Neighborhood Hits	632	Shared Neighborhood Hits	552
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 1358)	NC score	0.593103 (rank : 811)
Query Neighborhood Hits	1044	Target Neighborhood Hits	603	Shared Neighborhood Hits	524
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SDCG8_HUMAN
θ value	θ > 10 (rank : 1359)	NC score	0.082823 (rank : 925)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1002	Shared Neighborhood Hits	242
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

SH21A_HUMAN
θ value	θ > 10 (rank : 1360)	NC score	0.075802 (rank : 1021)
Query Neighborhood Hits	1044	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 1361)	NC score	0.081558 (rank : 945)
Query Neighborhood Hits	1044	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1362)	NC score	0.079261 (rank : 980)
Query Neighborhood Hits	1044	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1363)	NC score	0.088798 (rank : 884)
Query Neighborhood Hits	1044	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH24A_HUMAN
θ value	θ > 10 (rank : 1364)	NC score	0.082276 (rank : 928)
Query Neighborhood Hits	1044	Target Neighborhood Hits	455	Shared Neighborhood Hits	160
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SHE_HUMAN
θ value	θ > 10 (rank : 1365)	NC score	0.059635 (rank : 1215)
Query Neighborhood Hits	1044	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 1366)	NC score	0.059010 (rank : 1228)
Query Neighborhood Hits	1044	Target Neighborhood Hits	169	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 1367)	NC score	0.127212 (rank : 856)
Query Neighborhood Hits	1044	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 1368)	NC score	0.125656 (rank : 857)
Query Neighborhood Hits	1044	Target Neighborhood Hits	117	Shared Neighborhood Hits	41
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 1369)	NC score	0.128592 (rank : 855)
Query Neighborhood Hits	1044	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 1370)	NC score	0.133375 (rank : 854)
Query Neighborhood Hits	1044	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SM1L2_HUMAN
θ value	θ > 10 (rank : 1371)	NC score	0.074123 (rank : 1040)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1019	Shared Neighborhood Hits	222
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SMC2_HUMAN
θ value	θ > 10 (rank : 1372)	NC score	0.073661 (rank : 1046)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1405	Shared Neighborhood Hits	246
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SMC2_MOUSE
θ value	θ > 10 (rank : 1373)	NC score	0.056799 (rank : 1266)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1131	Shared Neighborhood Hits	217
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SMC4_HUMAN
θ value	θ > 10 (rank : 1374)	NC score	0.060762 (rank : 1194)
Query Neighborhood Hits	1044	Target Neighborhood Hits	937	Shared Neighborhood Hits	203
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

SPAG5_HUMAN
θ value	θ > 10 (rank : 1375)	NC score	0.053488 (rank : 1315)
Query Neighborhood Hits	1044	Target Neighborhood Hits	625	Shared Neighborhood Hits	169
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

SPAG5_MOUSE
θ value	θ > 10 (rank : 1376)	NC score	0.059918 (rank : 1209)
Query Neighborhood Hits	1044	Target Neighborhood Hits	612	Shared Neighborhood Hits	166
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

SPC24_HUMAN
θ value	θ > 10 (rank : 1377)	NC score	0.052423 (rank : 1329)
Query Neighborhood Hits	1044	Target Neighborhood Hits	324	Shared Neighborhood Hits	125
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

SPTA1_HUMAN
θ value	θ > 10 (rank : 1378)	NC score	0.056624 (rank : 1269)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	198
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 1379)	NC score	0.054324 (rank : 1301)
Query Neighborhood Hits	1044	Target Neighborhood Hits	675	Shared Neighborhood Hits	188
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 1380)	NC score	0.059538 (rank : 1219)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	202
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAC3_HUMAN
θ value	θ > 10 (rank : 1381)	NC score	0.095080 (rank : 864)
Query Neighborhood Hits	1044	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1382)	NC score	0.095755 (rank : 861)
Query Neighborhood Hits	1044	Target Neighborhood Hits	232	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1383)	NC score	0.088035 (rank : 887)
Query Neighborhood Hits	1044	Target Neighborhood Hits	276	Shared Neighborhood Hits	75
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1384)	NC score	0.094969 (rank : 865)
Query Neighborhood Hits	1044	Target Neighborhood Hits	268	Shared Neighborhood Hits	75
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STIM1_HUMAN
θ value	θ > 10 (rank : 1385)	NC score	0.056218 (rank : 1274)
Query Neighborhood Hits	1044	Target Neighborhood Hits	665	Shared Neighborhood Hits	197
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STIM1_MOUSE
θ value	θ > 10 (rank : 1386)	NC score	0.055626 (rank : 1282)
Query Neighborhood Hits	1044	Target Neighborhood Hits	660	Shared Neighborhood Hits	198
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STK31_HUMAN
θ value	θ > 10 (rank : 1387)	NC score	0.365778 (rank : 839)
Query Neighborhood Hits	1044	Target Neighborhood Hits	570	Shared Neighborhood Hits	431
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

STK31_MOUSE
θ value	θ > 10 (rank : 1388)	NC score	0.308333 (rank : 844)
Query Neighborhood Hits	1044	Target Neighborhood Hits	474	Shared Neighborhood Hits	366
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

STMN1_HUMAN
θ value	θ > 10 (rank : 1389)	NC score	0.052668 (rank : 1325)
Query Neighborhood Hits	1044	Target Neighborhood Hits	554	Shared Neighborhood Hits	181
SwissProt Accessions	P16949	Gene names	STMN1, LAP18, OP18
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Protein Pr22).

STMN1_MOUSE
θ value	θ > 10 (rank : 1390)	NC score	0.051804 (rank : 1336)
Query Neighborhood Hits	1044	Target Neighborhood Hits	560	Shared Neighborhood Hits	182
SwissProt Accessions	P54227	Gene names	Stmn1, Lag, Lap18, Pr22
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Pr22 protein) (Leukemia-associated gene protein).

STYK1_MOUSE
θ value	θ > 10 (rank : 1391)	NC score	0.670201 (rank : 752)
Query Neighborhood Hits	1044	Target Neighborhood Hits	779	Shared Neighborhood Hits	717
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SYCP1_HUMAN
θ value	θ > 10 (rank : 1392)	NC score	0.075542 (rank : 1028)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1313	Shared Neighborhood Hits	244
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYNE1_HUMAN
θ value	θ > 10 (rank : 1393)	NC score	0.057184 (rank : 1258)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1484	Shared Neighborhood Hits	235
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

SYNE2_HUMAN
θ value	θ > 10 (rank : 1394)	NC score	0.052300 (rank : 1330)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1323	Shared Neighborhood Hits	226
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

T3JAM_HUMAN
θ value	θ > 10 (rank : 1395)	NC score	0.060746 (rank : 1195)
Query Neighborhood Hits	1044	Target Neighborhood Hits	533	Shared Neighborhood Hits	159
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

TACC1_HUMAN
θ value	θ > 10 (rank : 1396)	NC score	0.054116 (rank : 1306)
Query Neighborhood Hits	1044	Target Neighborhood Hits	597	Shared Neighborhood Hits	178
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

TACC2_HUMAN
θ value	θ > 10 (rank : 1397)	NC score	0.063861 (rank : 1145)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	206
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TACC2_MOUSE
θ value	θ > 10 (rank : 1398)	NC score	0.053133 (rank : 1322)
Query Neighborhood Hits	1044	Target Neighborhood Hits	774	Shared Neighborhood Hits	184
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TACC3_MOUSE
θ value	θ > 10 (rank : 1399)	NC score	0.053403 (rank : 1317)
Query Neighborhood Hits	1044	Target Neighborhood Hits	607	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

TAXB1_HUMAN
θ value	θ > 10 (rank : 1400)	NC score	0.072198 (rank : 1064)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	205
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TAXB1_MOUSE
θ value	θ > 10 (rank : 1401)	NC score	0.074155 (rank : 1039)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	207
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

TCRG1_HUMAN
θ value	θ > 10 (rank : 1402)	NC score	0.059634 (rank : 1216)
Query Neighborhood Hits	1044	Target Neighborhood Hits	929	Shared Neighborhood Hits	204
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 1403)	NC score	0.060982 (rank : 1190)
Query Neighborhood Hits	1044	Target Neighborhood Hits	947	Shared Neighborhood Hits	203
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TEX14_HUMAN
θ value	θ > 10 (rank : 1404)	NC score	0.467018 (rank : 833)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1103	Shared Neighborhood Hits	571
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 1405)	NC score	0.511310 (rank : 822)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1333	Shared Neighborhood Hits	702
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX9_HUMAN
θ value	θ > 10 (rank : 1406)	NC score	0.057197 (rank : 1257)
Query Neighborhood Hits	1044	Target Neighborhood Hits	541	Shared Neighborhood Hits	156
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

TEX9_MOUSE
θ value	θ > 10 (rank : 1407)	NC score	0.061152 (rank : 1185)
Query Neighborhood Hits	1044	Target Neighborhood Hits	581	Shared Neighborhood Hits	175
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

TIE2_HUMAN
θ value	θ > 10 (rank : 1408)	NC score	0.695638 (rank : 714)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1192	Shared Neighborhood Hits	758
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 1409)	NC score	0.694602 (rank : 716)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1204	Shared Neighborhood Hits	758
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TMF1_HUMAN
θ value	θ > 10 (rank : 1410)	NC score	0.066420 (rank : 1119)
Query Neighborhood Hits	1044	Target Neighborhood Hits	987	Shared Neighborhood Hits	204
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

TNK1_HUMAN
θ value	θ > 10 (rank : 1411)	NC score	0.713226 (rank : 682)
Query Neighborhood Hits	1044	Target Neighborhood Hits	815	Shared Neighborhood Hits	723
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 1412)	NC score	0.722530 (rank : 656)
Query Neighborhood Hits	1044	Target Neighborhood Hits	806	Shared Neighborhood Hits	726
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TNNT2_HUMAN
θ value	θ > 10 (rank : 1413)	NC score	0.052961 (rank : 1323)
Query Neighborhood Hits	1044	Target Neighborhood Hits	433	Shared Neighborhood Hits	130
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TPM1_HUMAN
θ value	θ > 10 (rank : 1414)	NC score	0.057353 (rank : 1254)
Query Neighborhood Hits	1044	Target Neighborhood Hits	716	Shared Neighborhood Hits	177
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	θ > 10 (rank : 1415)	NC score	0.058904 (rank : 1230)
Query Neighborhood Hits	1044	Target Neighborhood Hits	729	Shared Neighborhood Hits	180
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM2_HUMAN
θ value	θ > 10 (rank : 1416)	NC score	0.054172 (rank : 1304)
Query Neighborhood Hits	1044	Target Neighborhood Hits	677	Shared Neighborhood Hits	163
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM2_MOUSE
θ value	θ > 10 (rank : 1417)	NC score	0.054279 (rank : 1302)
Query Neighborhood Hits	1044	Target Neighborhood Hits	676	Shared Neighborhood Hits	168
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM4_HUMAN
θ value	θ > 10 (rank : 1418)	NC score	0.053198 (rank : 1320)
Query Neighborhood Hits	1044	Target Neighborhood Hits	525	Shared Neighborhood Hits	147
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

TPM4_MOUSE
θ value	θ > 10 (rank : 1419)	NC score	0.057103 (rank : 1260)
Query Neighborhood Hits	1044	Target Neighborhood Hits	703	Shared Neighborhood Hits	185
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

TRAIP_HUMAN
θ value	θ > 10 (rank : 1420)	NC score	0.057039 (rank : 1263)
Query Neighborhood Hits	1044	Target Neighborhood Hits	780	Shared Neighborhood Hits	185
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

TRAIP_MOUSE
θ value	θ > 10 (rank : 1421)	NC score	0.055728 (rank : 1281)
Query Neighborhood Hits	1044	Target Neighborhood Hits	745	Shared Neighborhood Hits	172
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

TRAK1_HUMAN
θ value	θ > 10 (rank : 1422)	NC score	0.057255 (rank : 1256)
Query Neighborhood Hits	1044	Target Neighborhood Hits	660	Shared Neighborhood Hits	178
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

TRIB3_HUMAN
θ value	θ > 10 (rank : 1423)	NC score	0.725018 (rank : 648)
Query Neighborhood Hits	1044	Target Neighborhood Hits	519	Shared Neighborhood Hits	501
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TSC1_HUMAN
θ value	θ > 10 (rank : 1424)	NC score	0.076149 (rank : 1018)
Query Neighborhood Hits	1044	Target Neighborhood Hits	765	Shared Neighborhood Hits	197
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

TUFT1_HUMAN
θ value	θ > 10 (rank : 1425)	NC score	0.061743 (rank : 1176)
Query Neighborhood Hits	1044	Target Neighborhood Hits	686	Shared Neighborhood Hits	191
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

TUFT1_MOUSE
θ value	θ > 10 (rank : 1426)	NC score	0.058513 (rank : 1238)
Query Neighborhood Hits	1044	Target Neighborhood Hits	732	Shared Neighborhood Hits	193
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

TXLNA_HUMAN
θ value	θ > 10 (rank : 1427)	NC score	0.062538 (rank : 1167)
Query Neighborhood Hits	1044	Target Neighborhood Hits	982	Shared Neighborhood Hits	193
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

TXLNA_MOUSE
θ value	θ > 10 (rank : 1428)	NC score	0.064828 (rank : 1133)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	200
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

TXLNB_MOUSE
θ value	θ > 10 (rank : 1429)	NC score	0.055552 (rank : 1284)
Query Neighborhood Hits	1044	Target Neighborhood Hits	640	Shared Neighborhood Hits	155
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

TXLNG_HUMAN
θ value	θ > 10 (rank : 1430)	NC score	0.059911 (rank : 1210)
Query Neighborhood Hits	1044	Target Neighborhood Hits	568	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

TXLNG_MOUSE
θ value	θ > 10 (rank : 1431)	NC score	0.061279 (rank : 1181)
Query Neighborhood Hits	1044	Target Neighborhood Hits	552	Shared Neighborhood Hits	155
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

TYK2_HUMAN
θ value	θ > 10 (rank : 1432)	NC score	0.775762 (rank : 580)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	769
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 1433)	NC score	0.772042 (rank : 584)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	768
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

UN13A_HUMAN
θ value	θ > 10 (rank : 1434)	NC score	0.069301 (rank : 1095)
Query Neighborhood Hits	1044	Target Neighborhood Hits	285	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 1435)	NC score	0.068113 (rank : 1105)
Query Neighborhood Hits	1044	Target Neighborhood Hits	217	Shared Neighborhood Hits	47
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 1436)	NC score	0.065897 (rank : 1123)
Query Neighborhood Hits	1044	Target Neighborhood Hits	210	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 1437)	NC score	0.080934 (rank : 957)
Query Neighborhood Hits	1044	Target Neighborhood Hits	453	Shared Neighborhood Hits	94
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1438)	NC score	0.077400 (rank : 1002)
Query Neighborhood Hits	1044	Target Neighborhood Hits	456	Shared Neighborhood Hits	92
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1439)	NC score	0.084229 (rank : 916)
Query Neighborhood Hits	1044	Target Neighborhood Hits	398	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 1440)	NC score	0.083482 (rank : 919)
Query Neighborhood Hits	1044	Target Neighborhood Hits	404	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1441)	NC score	0.081402 (rank : 949)
Query Neighborhood Hits	1044	Target Neighborhood Hits	452	Shared Neighborhood Hits	91
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1442)	NC score	0.075748 (rank : 1025)
Query Neighborhood Hits	1044	Target Neighborhood Hits	430	Shared Neighborhood Hits	89
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VDP_HUMAN
θ value	θ > 10 (rank : 1443)	NC score	0.051910 (rank : 1334)
Query Neighborhood Hits	1044	Target Neighborhood Hits	645	Shared Neighborhood Hits	167
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

VGFR2_HUMAN
θ value	θ > 10 (rank : 1444)	NC score	0.616889 (rank : 800)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1103	Shared Neighborhood Hits	744
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 1445)	NC score	0.622192 (rank : 795)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1089	Shared Neighborhood Hits	742
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 1446)	NC score	0.626380 (rank : 791)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1037	Shared Neighborhood Hits	741
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 1447)	NC score	0.628316 (rank : 787)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1056	Shared Neighborhood Hits	739
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VRK1_HUMAN
θ value	θ > 10 (rank : 1448)	NC score	0.482616 (rank : 829)
Query Neighborhood Hits	1044	Target Neighborhood Hits	584	Shared Neighborhood Hits	559
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

VRK1_MOUSE
θ value	θ > 10 (rank : 1449)	NC score	0.483064 (rank : 828)
Query Neighborhood Hits	1044	Target Neighborhood Hits	583	Shared Neighborhood Hits	557
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK3_HUMAN
θ value	θ > 10 (rank : 1450)	NC score	0.263314 (rank : 847)
Query Neighborhood Hits	1044	Target Neighborhood Hits	349	Shared Neighborhood Hits	299
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VRK3_MOUSE
θ value	θ > 10 (rank : 1451)	NC score	0.245338 (rank : 848)
Query Neighborhood Hits	1044	Target Neighborhood Hits	342	Shared Neighborhood Hits	304
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

WDR67_HUMAN
θ value	θ > 10 (rank : 1452)	NC score	0.061099 (rank : 1187)
Query Neighborhood Hits	1044	Target Neighborhood Hits	782	Shared Neighborhood Hits	201
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

ZC313_HUMAN
θ value	θ > 10 (rank : 1453)	NC score	0.058363 (rank : 1239)
Query Neighborhood Hits	1044	Target Neighborhood Hits	772	Shared Neighborhood Hits	158
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZRF1_MOUSE
θ value	θ > 10 (rank : 1454)	NC score	0.052521 (rank : 1328)
Query Neighborhood Hits	1044	Target Neighborhood Hits	414	Shared Neighborhood Hits	126
SwissProt Accessions	P54103	Gene names	Zrf1, Dnajc2
Domain Architecture
Description	Zuotin-related factor 1.

ZWINT_MOUSE
θ value	θ > 10 (rank : 1455)	NC score	0.064149 (rank : 1141)
Query Neighborhood Hits	1044	Target Neighborhood Hits	497	Shared Neighborhood Hits	172
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

Hits sorted by NC score

TLK2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1044	Shared Neighborhood Hits	1044
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
NC score	0.996482 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1088	Shared Neighborhood Hits	987
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TLK1_HUMAN
NC score	0.991990 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	1044	Target Neighborhood Hits	967	Shared Neighborhood Hits	876
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
NC score	0.991578 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	1044	Target Neighborhood Hits	947	Shared Neighborhood Hits	863
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

AURKC_MOUSE
NC score	0.938165 (rank : 5)	θ value	1.73987e-27 (rank : 5)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	783
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

ULK3_MOUSE
NC score	0.937562 (rank : 6)	θ value	8.08199e-25 (rank : 8)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	785
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_HUMAN
NC score	0.936391 (rank : 7)	θ value	2.97466e-19 (rank : 92)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	775
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

AURKC_HUMAN
NC score	0.935931 (rank : 8)	θ value	2.59989e-23 (rank : 15)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	784
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

NUAK1_HUMAN
NC score	0.934168 (rank : 9)	θ value	8.36355e-22 (rank : 40)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	783
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

ULK2_MOUSE
NC score	0.934132 (rank : 10)	θ value	1.5773e-20 (rank : 60)
Query Neighborhood Hits	1044	Target Neighborhood Hits	943	Shared Neighborhood Hits	787
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

AURKB_HUMAN
NC score	0.934073 (rank : 11)	θ value	2.06002e-20 (rank : 61)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	784
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

NUAK1_MOUSE
NC score	0.933994 (rank : 12)	θ value	1.42661e-21 (rank : 45)
Query Neighborhood Hits	1044	Target Neighborhood Hits	881	Shared Neighborhood Hits	787
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

CHK2_MOUSE
NC score	0.933785 (rank : 13)	θ value	6.84181e-24 (rank : 11)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	775
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

STK6_MOUSE
NC score	0.933487 (rank : 14)	θ value	2.87452e-22 (rank : 29)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	785
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

PLK4_MOUSE
NC score	0.933265 (rank : 15)	θ value	6.40375e-22 (rank : 33)
Query Neighborhood Hits	1044	Target Neighborhood Hits	879	Shared Neighborhood Hits	784
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_HUMAN
NC score	0.933117 (rank : 16)	θ value	1.6852e-22 (rank : 23)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	784
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

AURKB_MOUSE
NC score	0.933030 (rank : 17)	θ value	1.09232e-21 (rank : 42)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	785
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

ULK2_HUMAN
NC score	0.932891 (rank : 18)	θ value	2.69047e-20 (rank : 64)
Query Neighborhood Hits	1044	Target Neighborhood Hits	979	Shared Neighborhood Hits	785
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

CHK2_HUMAN
NC score	0.932681 (rank : 19)	θ value	3.39556e-23 (rank : 17)
Query Neighborhood Hits	1044	Target Neighborhood Hits	859	Shared Neighborhood Hits	777
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

STK6_HUMAN
NC score	0.932615 (rank : 20)	θ value	8.36355e-22 (rank : 41)
Query Neighborhood Hits	1044	Target Neighborhood Hits	916	Shared Neighborhood Hits	789
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

SNRK_MOUSE
NC score	0.931780 (rank : 21)	θ value	7.82807e-20 (rank : 76)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	765
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

NUAK2_HUMAN
NC score	0.931635 (rank : 22)	θ value	3.75424e-22 (rank : 32)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	784
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

STK36_HUMAN
NC score	0.931399 (rank : 23)	θ value	2.59989e-23 (rank : 16)
Query Neighborhood Hits	1044	Target Neighborhood Hits	896	Shared Neighborhood Hits	786
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

SNRK_HUMAN
NC score	0.931372 (rank : 24)	θ value	7.82807e-20 (rank : 75)
Query Neighborhood Hits	1044	Target Neighborhood Hits	855	Shared Neighborhood Hits	769
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

ULK1_HUMAN
NC score	0.931364 (rank : 25)	θ value	6.40375e-22 (rank : 35)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1121	Shared Neighborhood Hits	787
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

DAPK2_MOUSE
NC score	0.930708 (rank : 26)	θ value	2.87452e-22 (rank : 28)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	770
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

CHK1_HUMAN
NC score	0.930392 (rank : 27)	θ value	2.5182e-18 (rank : 129)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	777
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

STK36_MOUSE
NC score	0.930045 (rank : 28)	θ value	7.0802e-21 (rank : 54)
Query Neighborhood Hits	1044	Target Neighborhood Hits	877	Shared Neighborhood Hits	785
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ST17A_HUMAN
NC score	0.930017 (rank : 29)	θ value	7.56453e-23 (rank : 20)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	769
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

KCC1A_MOUSE
NC score	0.929796 (rank : 30)	θ value	4.01107e-24 (rank : 9)
Query Neighborhood Hits	1044	Target Neighborhood Hits	845	Shared Neighborhood Hits	775
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

DAPK3_HUMAN
NC score	0.929691 (rank : 31)	θ value	1.47631e-18 (rank : 123)
Query Neighborhood Hits	1044	Target Neighborhood Hits	945	Shared Neighborhood Hits	807
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KCC1G_HUMAN
NC score	0.929659 (rank : 32)	θ value	1.5242e-23 (rank : 12)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	774
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1A_HUMAN
NC score	0.929574 (rank : 33)	θ value	5.23862e-24 (rank : 10)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	775
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1G_MOUSE
NC score	0.929504 (rank : 34)	θ value	1.5242e-23 (rank : 13)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	774
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

CHK1_MOUSE
NC score	0.929432 (rank : 35)	θ value	5.25075e-16 (rank : 196)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	777
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

NUAK2_MOUSE
NC score	0.929396 (rank : 36)	θ value	5.99374e-20 (rank : 72)
Query Neighborhood Hits	1044	Target Neighborhood Hits	878	Shared Neighborhood Hits	781
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

PLK2_HUMAN
NC score	0.928746 (rank : 37)	θ value	9.54697e-26 (rank : 6)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	782
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

KCC4_MOUSE
NC score	0.928714 (rank : 38)	θ value	8.65492e-19 (rank : 110)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	783
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

PLK2_MOUSE
NC score	0.928549 (rank : 39)	θ value	9.54697e-26 (rank : 7)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	781
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

ULK1_MOUSE
NC score	0.928424 (rank : 40)	θ value	5.42112e-21 (rank : 52)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1214	Shared Neighborhood Hits	791
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

DAPK3_MOUSE
NC score	0.928327 (rank : 41)	θ value	1.02238e-19 (rank : 79)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	771
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

BRSK1_HUMAN
NC score	0.928214 (rank : 42)	θ value	3.88503e-19 (rank : 93)
Query Neighborhood Hits	1044	Target Neighborhood Hits	942	Shared Neighborhood Hits	776
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

STK33_HUMAN
NC score	0.928127 (rank : 43)	θ value	6.41864e-14 (rank : 297)
Query Neighborhood Hits	1044	Target Neighborhood Hits	879	Shared Neighborhood Hits	783
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

KCC4_HUMAN
NC score	0.928033 (rank : 44)	θ value	1.47631e-18 (rank : 125)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	773
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

DAPK2_HUMAN
NC score	0.927540 (rank : 45)	θ value	3.17815e-21 (rank : 49)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	766
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

KCC1B_MOUSE
NC score	0.927455 (rank : 46)	θ value	1.13037e-18 (rank : 120)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	779
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

NIM1_MOUSE
NC score	0.927436 (rank : 47)	θ value	4.02038e-16 (rank : 194)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	780
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

BRSK2_HUMAN
NC score	0.927248 (rank : 48)	θ value	3.07829e-16 (rank : 184)
Query Neighborhood Hits	1044	Target Neighborhood Hits	897	Shared Neighborhood Hits	783
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

NIM1_HUMAN
NC score	0.927207 (rank : 49)	θ value	6.20254e-17 (rank : 162)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	779
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KCC1B_HUMAN
NC score	0.927151 (rank : 50)	θ value	1.47631e-18 (rank : 124)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	779
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

DCAK3_HUMAN
NC score	0.927020 (rank : 51)	θ value	2.60593e-15 (rank : 218)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	781
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

HUNK_HUMAN
NC score	0.926863 (rank : 52)	θ value	5.99374e-20 (rank : 70)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	781
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

TSSK1_MOUSE
NC score	0.926821 (rank : 53)	θ value	8.65492e-19 (rank : 116)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	770
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

DCAK3_MOUSE
NC score	0.926799 (rank : 54)	θ value	2.88119e-14 (rank : 280)
Query Neighborhood Hits	1044	Target Neighborhood Hits	922	Shared Neighborhood Hits	783
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

HUNK_MOUSE
NC score	0.926746 (rank : 55)	θ value	4.58923e-20 (rank : 66)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	781
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

MARK4_HUMAN
NC score	0.926395 (rank : 56)	θ value	5.79196e-23 (rank : 18)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	783
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
NC score	0.926344 (rank : 57)	θ value	5.79196e-23 (rank : 19)
Query Neighborhood Hits	1044	Target Neighborhood Hits	898	Shared Neighborhood Hits	782
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

KCC1D_HUMAN
NC score	0.926112 (rank : 58)	θ value	1.74391e-19 (rank : 83)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	774
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
NC score	0.926077 (rank : 59)	θ value	1.74391e-19 (rank : 84)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	774
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

AAPK1_MOUSE
NC score	0.926020 (rank : 60)	θ value	1.058e-16 (rank : 172)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	779
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_HUMAN
NC score	0.925984 (rank : 61)	θ value	1.058e-16 (rank : 171)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	779
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

MYLK2_HUMAN
NC score	0.925696 (rank : 62)	θ value	1.68911e-14 (rank : 270)
Query Neighborhood Hits	1044	Target Neighborhood Hits	920	Shared Neighborhood Hits	764
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

PLK3_HUMAN
NC score	0.925480 (rank : 63)	θ value	5.07402e-19 (rank : 98)
Query Neighborhood Hits	1044	Target Neighborhood Hits	865	Shared Neighborhood Hits	781
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
NC score	0.925438 (rank : 64)	θ value	1.47631e-18 (rank : 127)
Query Neighborhood Hits	1044	Target Neighborhood Hits	863	Shared Neighborhood Hits	780
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

SN1L1_HUMAN
NC score	0.925307 (rank : 65)	θ value	3.63628e-17 (rank : 157)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	782
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
NC score	0.925306 (rank : 66)	θ value	1.80466e-16 (rank : 181)
Query Neighborhood Hits	1044	Target Neighborhood Hits	895	Shared Neighborhood Hits	782
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

ST17B_MOUSE
NC score	0.925141 (rank : 67)	θ value	8.95645e-16 (rank : 204)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	771
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

AAPK2_HUMAN
NC score	0.925076 (rank : 68)	θ value	1.47631e-18 (rank : 122)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	778
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

KCC2A_HUMAN
NC score	0.924775 (rank : 69)	θ value	2.20094e-22 (rank : 24)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	769
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KKCC2_HUMAN
NC score	0.924732 (rank : 70)	θ value	8.65492e-19 (rank : 111)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	779
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
NC score	0.924717 (rank : 71)	θ value	8.65492e-19 (rank : 112)
Query Neighborhood Hits	1044	Target Neighborhood Hits	855	Shared Neighborhood Hits	779
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KCC2G_HUMAN
NC score	0.924617 (rank : 72)	θ value	9.87957e-23 (rank : 21)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	770
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

TSSK2_HUMAN
NC score	0.924616 (rank : 73)	θ value	2.27762e-19 (rank : 88)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	766
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

KPSH1_HUMAN
NC score	0.924606 (rank : 74)	θ value	1.058e-16 (rank : 174)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	774
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KCC2G_MOUSE
NC score	0.924577 (rank : 75)	θ value	9.87957e-23 (rank : 22)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	770
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KPSH2_HUMAN
NC score	0.924470 (rank : 76)	θ value	2.7842e-17 (rank : 153)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	766
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

TSSK4_MOUSE
NC score	0.924428 (rank : 77)	θ value	1.99529e-15 (rank : 215)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	780
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

KPSH1_MOUSE
NC score	0.924421 (rank : 78)	θ value	1.80466e-16 (rank : 180)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	774
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

PHKG1_MOUSE
NC score	0.924389 (rank : 79)	θ value	3.07829e-16 (rank : 190)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	774
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

KKCC1_MOUSE
NC score	0.924321 (rank : 80)	θ value	7.32683e-18 (rank : 139)
Query Neighborhood Hits	1044	Target Neighborhood Hits	866	Shared Neighborhood Hits	780
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PHKG1_HUMAN
NC score	0.924296 (rank : 81)	θ value	3.88503e-19 (rank : 94)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	774
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

ST17B_HUMAN
NC score	0.924249 (rank : 82)	θ value	6.20254e-17 (rank : 165)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	770
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MARK1_MOUSE
NC score	0.924082 (rank : 83)	θ value	3.17815e-21 (rank : 50)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	783
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

STK11_HUMAN
NC score	0.924032 (rank : 84)	θ value	3.89403e-11 (rank : 430)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	773
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

MARK3_MOUSE
NC score	0.923981 (rank : 85)	θ value	2.43343e-21 (rank : 48)
Query Neighborhood Hits	1044	Target Neighborhood Hits	919	Shared Neighborhood Hits	783
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

KKCC1_HUMAN
NC score	0.923894 (rank : 86)	θ value	2.13179e-17 (rank : 147)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	779
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KCC2A_MOUSE
NC score	0.923623 (rank : 87)	θ value	3.75424e-22 (rank : 31)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	767
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

PLK1_MOUSE
NC score	0.923586 (rank : 88)	θ value	5.60996e-18 (rank : 138)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	776
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

MARK1_HUMAN
NC score	0.923435 (rank : 89)	θ value	7.0802e-21 (rank : 53)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	781
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

PHKG2_MOUSE
NC score	0.923230 (rank : 90)	θ value	5.8054e-15 (rank : 242)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	772
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

K0999_HUMAN
NC score	0.923150 (rank : 91)	θ value	5.99374e-20 (rank : 71)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	781
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

PHKG2_HUMAN
NC score	0.923128 (rank : 92)	θ value	1.52774e-15 (rank : 209)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	773
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

NEK3_MOUSE
NC score	0.922874 (rank : 93)	θ value	6.20254e-17 (rank : 160)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	782
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

KPCD2_HUMAN
NC score	0.922872 (rank : 94)	θ value	4.29542e-18 (rank : 134)
Query Neighborhood Hits	1044	Target Neighborhood Hits	910	Shared Neighborhood Hits	775
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KCC2D_HUMAN
NC score	0.922831 (rank : 95)	θ value	2.20094e-22 (rank : 25)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	771
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

K0999_MOUSE
NC score	0.922748 (rank : 96)	θ value	4.58923e-20 (rank : 67)
Query Neighborhood Hits	1044	Target Neighborhood Hits	931	Shared Neighborhood Hits	781
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

SN1L2_HUMAN
NC score	0.922693 (rank : 97)	θ value	3.28887e-18 (rank : 133)
Query Neighborhood Hits	1044	Target Neighborhood Hits	964	Shared Neighborhood Hits	790
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
NC score	0.922661 (rank : 98)	θ value	1.13037e-18 (rank : 121)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	787
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

MARK2_HUMAN
NC score	0.922570 (rank : 99)	θ value	5.42112e-21 (rank : 51)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1056	Shared Neighborhood Hits	791
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

NEK3_HUMAN
NC score	0.922558 (rank : 100)	θ value	4.02038e-16 (rank : 192)
Query Neighborhood Hits	1044	Target Neighborhood Hits	865	Shared Neighborhood Hits	787
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

KPCD1_HUMAN
NC score	0.922507 (rank : 101)	θ value	1.02238e-19 (rank : 80)
Query Neighborhood Hits	1044	Target Neighborhood Hits	901	Shared Neighborhood Hits	774
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PDPK1_HUMAN
NC score	0.922417 (rank : 102)	θ value	1.2077e-20 (rank : 58)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	779
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
NC score	0.922416 (rank : 103)	θ value	1.2077e-20 (rank : 59)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	778
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PLK1_HUMAN
NC score	0.922412 (rank : 104)	θ value	2.5182e-18 (rank : 130)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	775
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KPCD1_MOUSE
NC score	0.922263 (rank : 105)	θ value	5.07402e-19 (rank : 97)
Query Neighborhood Hits	1044	Target Neighborhood Hits	891	Shared Neighborhood Hits	775
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PASK_MOUSE
NC score	0.921924 (rank : 106)	θ value	1.133e-10 (rank : 451)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	774
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

KCC2B_HUMAN
NC score	0.921917 (rank : 107)	θ value	1.2077e-20 (rank : 56)
Query Neighborhood Hits	1044	Target Neighborhood Hits	866	Shared Neighborhood Hits	768
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

MARK2_MOUSE
NC score	0.921876 (rank : 108)	θ value	4.58923e-20 (rank : 68)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1018	Shared Neighborhood Hits	782
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

NEK2_MOUSE
NC score	0.921788 (rank : 109)	θ value	9.26847e-13 (rank : 360)
Query Neighborhood Hits	1044	Target Neighborhood Hits	876	Shared Neighborhood Hits	781
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

TSSK6_MOUSE
NC score	0.921537 (rank : 110)	θ value	2.0648e-12 (rank : 378)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	765
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

IKKB_MOUSE
NC score	0.921457 (rank : 111)	θ value	5.07402e-19 (rank : 96)
Query Neighborhood Hits	1044	Target Neighborhood Hits	984	Shared Neighborhood Hits	836
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_HUMAN
NC score	0.921328 (rank : 112)	θ value	1.13037e-18 (rank : 119)
Query Neighborhood Hits	1044	Target Neighborhood Hits	980	Shared Neighborhood Hits	836
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

NEK6_HUMAN
NC score	0.921309 (rank : 113)	θ value	3.28887e-18 (rank : 132)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	784
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.921269 (rank : 114)	θ value	5.60996e-18 (rank : 135)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	784
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK2_HUMAN
NC score	0.921106 (rank : 115)	θ value	1.86753e-13 (rank : 320)
Query Neighborhood Hits	1044	Target Neighborhood Hits	908	Shared Neighborhood Hits	795
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

TSSK3_HUMAN
NC score	0.921071 (rank : 116)	θ value	3.51386e-20 (rank : 65)
Query Neighborhood Hits	1044	Target Neighborhood Hits	806	Shared Neighborhood Hits	756
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK6_HUMAN
NC score	0.920989 (rank : 117)	θ value	6.00763e-12 (rank : 400)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	767
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK4_HUMAN
NC score	0.920752 (rank : 118)	θ value	5.8054e-15 (rank : 244)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	776
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK1_HUMAN
NC score	0.920658 (rank : 119)	θ value	3.40345e-15 (rank : 229)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	761
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KCC2B_MOUSE
NC score	0.920486 (rank : 120)	θ value	1.2077e-20 (rank : 57)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	767
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

MELK_HUMAN
NC score	0.920142 (rank : 121)	θ value	3.07829e-16 (rank : 186)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	776
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

NEK4_MOUSE
NC score	0.920095 (rank : 122)	θ value	8.65492e-19 (rank : 115)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	784
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

TSSK3_MOUSE
NC score	0.920041 (rank : 123)	θ value	2.97466e-19 (rank : 91)
Query Neighborhood Hits	1044	Target Neighborhood Hits	806	Shared Neighborhood Hits	757
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

NEK11_MOUSE
NC score	0.919969 (rank : 124)	θ value	1.24977e-17 (rank : 143)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	789
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

KPCD3_MOUSE
NC score	0.919833 (rank : 125)	θ value	8.65492e-19 (rank : 113)
Query Neighborhood Hits	1044	Target Neighborhood Hits	901	Shared Neighborhood Hits	771
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

MELK_MOUSE
NC score	0.919707 (rank : 126)	θ value	2.20605e-14 (rank : 278)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	775
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

NEK11_HUMAN
NC score	0.919704 (rank : 127)	θ value	2.27762e-19 (rank : 87)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1043	Shared Neighborhood Hits	848
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

KPCD3_HUMAN
NC score	0.919550 (rank : 128)	θ value	6.62687e-19 (rank : 101)
Query Neighborhood Hits	1044	Target Neighborhood Hits	895	Shared Neighborhood Hits	770
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

TSSK2_MOUSE
NC score	0.918647 (rank : 129)	θ value	6.20254e-17 (rank : 166)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	762
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

NEK1_HUMAN
NC score	0.918234 (rank : 130)	θ value	4.44505e-15 (rank : 235)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1129	Shared Neighborhood Hits	858
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

IKKA_MOUSE
NC score	0.918076 (rank : 131)	θ value	1.13037e-18 (rank : 118)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	787
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

NEK4_HUMAN
NC score	0.917939 (rank : 132)	θ value	6.20254e-17 (rank : 161)
Query Neighborhood Hits	1044	Target Neighborhood Hits	883	Shared Neighborhood Hits	781
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

DCAK1_MOUSE
NC score	0.917771 (rank : 133)	θ value	2.69047e-20 (rank : 63)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	776
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

NEK1_MOUSE
NC score	0.917767 (rank : 134)	θ value	8.65492e-19 (rank : 114)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1311	Shared Neighborhood Hits	868
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

DCAK1_HUMAN
NC score	0.917630 (rank : 135)	θ value	1.74391e-19 (rank : 82)
Query Neighborhood Hits	1044	Target Neighborhood Hits	877	Shared Neighborhood Hits	777
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

PASK_HUMAN
NC score	0.916907 (rank : 136)	θ value	3.29651e-10 (rank : 475)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	769
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

MARK3_HUMAN
NC score	0.916732 (rank : 137)	θ value	9.56915e-18 (rank : 142)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	778
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

PIM2_MOUSE
NC score	0.916124 (rank : 138)	θ value	2.20094e-22 (rank : 26)
Query Neighborhood Hits	1044	Target Neighborhood Hits	809	Shared Neighborhood Hits	751
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

IKKA_HUMAN
NC score	0.916005 (rank : 139)	θ value	2.7842e-17 (rank : 152)
Query Neighborhood Hits	1044	Target Neighborhood Hits	863	Shared Neighborhood Hits	782
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

NEK7_MOUSE
NC score	0.915890 (rank : 140)	θ value	4.02038e-16 (rank : 193)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	784
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

DCAK2_MOUSE
NC score	0.915844 (rank : 141)	θ value	3.28887e-18 (rank : 131)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	774
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

NEK7_HUMAN
NC score	0.915689 (rank : 142)	θ value	1.058e-16 (rank : 177)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	782
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

ST32A_MOUSE
NC score	0.915573 (rank : 143)	θ value	1.47631e-18 (rank : 128)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	777
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

DCAK2_HUMAN
NC score	0.915064 (rank : 144)	θ value	6.62687e-19 (rank : 100)
Query Neighborhood Hits	1044	Target Neighborhood Hits	862	Shared Neighborhood Hits	773
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

ST32A_HUMAN
NC score	0.915041 (rank : 145)	θ value	5.07402e-19 (rank : 99)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	776
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

PIM2_HUMAN
NC score	0.914793 (rank : 146)	θ value	9.24701e-21 (rank : 55)
Query Neighborhood Hits	1044	Target Neighborhood Hits	808	Shared Neighborhood Hits	757
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

IKKE_HUMAN
NC score	0.913463 (rank : 147)	θ value	3.40345e-15 (rank : 226)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	773
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IKKE_MOUSE
NC score	0.913012 (rank : 148)	θ value	9.90251e-15 (rank : 257)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	778
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

ST32B_MOUSE
NC score	0.912245 (rank : 149)	θ value	7.82807e-20 (rank : 77)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	773
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

PIM1_HUMAN
NC score	0.912180 (rank : 150)	θ value	7.32683e-18 (rank : 140)
Query Neighborhood Hits	1044	Target Neighborhood Hits	797	Shared Neighborhood Hits	744
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PRKY_HUMAN
NC score	0.912162 (rank : 151)	θ value	3.18553e-13 (rank : 333)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	779
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

E2AK2_MOUSE
NC score	0.912080 (rank : 152)	θ value	3.29651e-10 (rank : 469)
Query Neighborhood Hits	1044	Target Neighborhood Hits	864	Shared Neighborhood Hits	782
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

ST32C_MOUSE
NC score	0.911910 (rank : 153)	θ value	6.62687e-19 (rank : 104)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	772
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

M3K2_HUMAN
NC score	0.911796 (rank : 154)	θ value	7.58209e-15 (rank : 250)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	779
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K1_MOUSE
NC score	0.911703 (rank : 155)	θ value	1.63604e-09 (rank : 511)
Query Neighborhood Hits	1044	Target Neighborhood Hits	952	Shared Neighborhood Hits	787
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

TTK_HUMAN
NC score	0.911585 (rank : 156)	θ value	1.99067e-23 (rank : 14)
Query Neighborhood Hits	1044	Target Neighborhood Hits	816	Shared Neighborhood Hits	745
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

ST32B_HUMAN
NC score	0.911353 (rank : 157)	θ value	4.58923e-20 (rank : 69)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	774
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

M3K4_HUMAN
NC score	0.911202 (rank : 158)	θ value	6.00763e-12 (rank : 397)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	793
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K2_MOUSE
NC score	0.911180 (rank : 159)	θ value	1.68911e-14 (rank : 269)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	775
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K4_MOUSE
NC score	0.911121 (rank : 160)	θ value	9.26847e-13 (rank : 358)
Query Neighborhood Hits	1044	Target Neighborhood Hits	924	Shared Neighborhood Hits	792
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

SBK1_MOUSE
NC score	0.911041 (rank : 161)	θ value	2.79066e-09 (rank : 528)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	756
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

PIM1_MOUSE
NC score	0.910839 (rank : 162)	θ value	3.88503e-19 (rank : 95)
Query Neighborhood Hits	1044	Target Neighborhood Hits	787	Shared Neighborhood Hits	735
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

TBK1_MOUSE
NC score	0.910839 (rank : 163)	θ value	2.88119e-14 (rank : 283)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	801
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

CDKL4_MOUSE
NC score	0.910613 (rank : 164)	θ value	1.13037e-18 (rank : 117)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	774
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

MAPK2_HUMAN
NC score	0.910488 (rank : 165)	θ value	2.13179e-17 (rank : 150)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	766
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

M3K3_MOUSE
NC score	0.910397 (rank : 166)	θ value	1.52774e-15 (rank : 206)
Query Neighborhood Hits	1044	Target Neighborhood Hits	876	Shared Neighborhood Hits	778
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K5_MOUSE
NC score	0.910334 (rank : 167)	θ value	1.99529e-15 (rank : 213)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	782
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_HUMAN
NC score	0.910250 (rank : 168)	θ value	1.99529e-15 (rank : 212)
Query Neighborhood Hits	1044	Target Neighborhood Hits	868	Shared Neighborhood Hits	783
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
NC score	0.910210 (rank : 169)	θ value	2.69671e-12 (rank : 383)
Query Neighborhood Hits	1044	Target Neighborhood Hits	889	Shared Neighborhood Hits	781
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

SBK1_HUMAN
NC score	0.910209 (rank : 170)	θ value	1.63604e-09 (rank : 516)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	758
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

M3K3_HUMAN
NC score	0.910157 (rank : 171)	θ value	1.99529e-15 (rank : 211)
Query Neighborhood Hits	1044	Target Neighborhood Hits	885	Shared Neighborhood Hits	779
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

PAK2_MOUSE
NC score	0.910047 (rank : 172)	θ value	3.07829e-16 (rank : 189)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	784
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK2_HUMAN
NC score	0.910034 (rank : 173)	θ value	3.07829e-16 (rank : 188)
Query Neighborhood Hits	1044	Target Neighborhood Hits	862	Shared Neighborhood Hits	786
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

ST32C_HUMAN
NC score	0.909902 (rank : 174)	θ value	6.62687e-19 (rank : 103)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	772
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

TBK1_HUMAN
NC score	0.909836 (rank : 175)	θ value	4.91457e-14 (rank : 292)
Query Neighborhood Hits	1044	Target Neighborhood Hits	861	Shared Neighborhood Hits	781
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

MAPK2_MOUSE
NC score	0.909683 (rank : 176)	θ value	2.7842e-17 (rank : 154)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	764
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

PAK6_HUMAN
NC score	0.908525 (rank : 177)	θ value	1.86753e-13 (rank : 322)
Query Neighborhood Hits	1044	Target Neighborhood Hits	915	Shared Neighborhood Hits	780
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_MOUSE
NC score	0.908475 (rank : 178)	θ value	9.26847e-13 (rank : 361)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	783
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PAK7_HUMAN
NC score	0.908316 (rank : 179)	θ value	1.2105e-12 (rank : 366)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	781
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

NEK8_HUMAN
NC score	0.908296 (rank : 180)	θ value	6.41864e-14 (rank : 296)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	782
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

M3K15_HUMAN
NC score	0.908208 (rank : 181)	θ value	1.09485e-13 (rank : 308)
Query Neighborhood Hits	1044	Target Neighborhood Hits	914	Shared Neighborhood Hits	798
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

NEK8_MOUSE
NC score	0.908047 (rank : 182)	θ value	1.09485e-13 (rank : 310)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	782
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

CDKL3_MOUSE
NC score	0.908002 (rank : 183)	θ value	3.89403e-11 (rank : 428)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	775
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

KAPCG_HUMAN
NC score	0.907697 (rank : 184)	θ value	9.90251e-15 (rank : 258)
Query Neighborhood Hits	1044	Target Neighborhood Hits	845	Shared Neighborhood Hits	776
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

ULK4_MOUSE
NC score	0.907480 (rank : 185)	θ value	6.21693e-09 (rank : 537)
Query Neighborhood Hits	1044	Target Neighborhood Hits	793	Shared Neighborhood Hits	728
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

CDKL3_HUMAN
NC score	0.907391 (rank : 186)	θ value	1.133e-10 (rank : 447)
Query Neighborhood Hits	1044	Target Neighborhood Hits	853	Shared Neighborhood Hits	777
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

SGK1_HUMAN
NC score	0.907370 (rank : 187)	θ value	7.82807e-20 (rank : 74)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	780
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

TTK_MOUSE
NC score	0.907326 (rank : 188)	θ value	6.40375e-22 (rank : 34)
Query Neighborhood Hits	1044	Target Neighborhood Hits	803	Shared Neighborhood Hits	728
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

PAK3_MOUSE
NC score	0.907055 (rank : 189)	θ value	1.68911e-14 (rank : 272)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	786
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK1_HUMAN
NC score	0.907051 (rank : 190)	θ value	7.58209e-15 (rank : 253)
Query Neighborhood Hits	1044	Target Neighborhood Hits	873	Shared Neighborhood Hits	785
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

KS6A2_MOUSE
NC score	0.906969 (rank : 191)	θ value	5.43371e-13 (rank : 346)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	784
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A6_HUMAN
NC score	0.906913 (rank : 192)	θ value	5.8054e-15 (rank : 238)
Query Neighborhood Hits	1044	Target Neighborhood Hits	853	Shared Neighborhood Hits	780
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

SGK1_MOUSE
NC score	0.906865 (rank : 193)	θ value	1.33526e-19 (rank : 81)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	781
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

PAK3_HUMAN
NC score	0.906825 (rank : 194)	θ value	1.68911e-14 (rank : 271)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	787
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

CDK7_MOUSE
NC score	0.906811 (rank : 195)	θ value	2.97466e-19 (rank : 90)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	774
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDKL1_HUMAN
NC score	0.906719 (rank : 196)	θ value	7.58209e-15 (rank : 247)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	773
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDK7_HUMAN
NC score	0.906694 (rank : 197)	θ value	2.97466e-19 (rank : 89)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	774
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

KS6A2_HUMAN
NC score	0.906455 (rank : 198)	θ value	1.42992e-13 (rank : 311)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	785
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PAK4_HUMAN
NC score	0.906293 (rank : 199)	θ value	7.84624e-12 (rank : 405)
Query Neighborhood Hits	1044	Target Neighborhood Hits	924	Shared Neighborhood Hits	781
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

CDKL4_HUMAN
NC score	0.906243 (rank : 200)	θ value	3.07829e-16 (rank : 185)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	771
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

PIM3_HUMAN
NC score	0.905714 (rank : 201)	θ value	9.90251e-15 (rank : 263)
Query Neighborhood Hits	1044	Target Neighborhood Hits	789	Shared Neighborhood Hits	746
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PAK1_MOUSE
NC score	0.905688 (rank : 202)	θ value	1.86753e-13 (rank : 321)
Query Neighborhood Hits	1044	Target Neighborhood Hits	878	Shared Neighborhood Hits	784
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

CDKL1_MOUSE
NC score	0.905582 (rank : 203)	θ value	5.8054e-15 (rank : 236)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	770
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

MAPK3_MOUSE
NC score	0.905527 (rank : 204)	θ value	7.09661e-13 (rank : 353)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	754
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MKNK2_HUMAN
NC score	0.905417 (rank : 205)	θ value	2.43908e-13 (rank : 324)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	767
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

PRKX_MOUSE
NC score	0.905412 (rank : 206)	θ value	4.16044e-13 (rank : 338)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	781
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

KS6A1_HUMAN
NC score	0.905411 (rank : 207)	θ value	2.60593e-15 (rank : 220)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	783
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A3_MOUSE
NC score	0.905357 (rank : 208)	θ value	9.90251e-15 (rank : 260)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	784
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.905341 (rank : 209)	θ value	9.90251e-15 (rank : 259)
Query Neighborhood Hits	1044	Target Neighborhood Hits	859	Shared Neighborhood Hits	784
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PIM3_MOUSE
NC score	0.905144 (rank : 210)	θ value	4.91457e-14 (rank : 290)
Query Neighborhood Hits	1044	Target Neighborhood Hits	783	Shared Neighborhood Hits	740
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

KS6A5_HUMAN
NC score	0.905124 (rank : 211)	θ value	8.95645e-16 (rank : 203)
Query Neighborhood Hits	1044	Target Neighborhood Hits	855	Shared Neighborhood Hits	782
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6B1_MOUSE
NC score	0.904556 (rank : 212)	θ value	2.13179e-17 (rank : 149)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	779
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.904536 (rank : 213)	θ value	2.13179e-17 (rank : 148)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	779
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

PRKX_HUMAN
NC score	0.904435 (rank : 214)	θ value	3.18553e-13 (rank : 332)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	779
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

SGK2_MOUSE
NC score	0.904053 (rank : 215)	θ value	6.62687e-19 (rank : 102)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	775
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

CDC2_MOUSE
NC score	0.903830 (rank : 216)	θ value	7.58209e-15 (rank : 245)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	778
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

MKNK2_MOUSE
NC score	0.903788 (rank : 217)	θ value	1.86753e-13 (rank : 316)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	766
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

SGK2_HUMAN
NC score	0.903680 (rank : 218)	θ value	6.20254e-17 (rank : 164)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	777
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

CDC2_HUMAN
NC score	0.903675 (rank : 219)	θ value	4.44505e-15 (rank : 230)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	780
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

PDK1L_HUMAN
NC score	0.903625 (rank : 220)	θ value	1.47974e-10 (rank : 456)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	770
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

MAPK3_HUMAN
NC score	0.903603 (rank : 221)	θ value	7.84624e-12 (rank : 404)
Query Neighborhood Hits	1044	Target Neighborhood Hits	807	Shared Neighborhood Hits	747
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

KAPCB_HUMAN
NC score	0.903597 (rank : 222)	θ value	5.8054e-15 (rank : 237)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	775
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

MKNK1_MOUSE
NC score	0.903592 (rank : 223)	θ value	1.058e-16 (rank : 176)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	754
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

PDK1L_MOUSE
NC score	0.903449 (rank : 224)	θ value	1.133e-10 (rank : 452)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	770
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

KAPCA_MOUSE
NC score	0.903229 (rank : 225)	θ value	8.38298e-14 (rank : 299)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	773
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

PAK4_MOUSE
NC score	0.903212 (rank : 226)	θ value	1.133e-10 (rank : 450)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1098	Shared Neighborhood Hits	785
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

KAPCA_HUMAN
NC score	0.903208 (rank : 227)	θ value	8.38298e-14 (rank : 298)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	775
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_MOUSE
NC score	0.903124 (rank : 228)	θ value	7.58209e-15 (rank : 248)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	775
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

AKT3_HUMAN
NC score	0.902971 (rank : 229)	θ value	8.36355e-22 (rank : 37)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	782
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.902951 (rank : 230)	θ value	8.36355e-22 (rank : 38)
Query Neighborhood Hits	1044	Target Neighborhood Hits	872	Shared Neighborhood Hits	782
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

KS6A1_MOUSE
NC score	0.902701 (rank : 231)	θ value	4.16044e-13 (rank : 336)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	780
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

CDKL2_MOUSE
NC score	0.902576 (rank : 232)	θ value	2.98157e-11 (rank : 423)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	775
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

KS6B2_HUMAN
NC score	0.902166 (rank : 233)	θ value	2.35696e-16 (rank : 182)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	777
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

MP2K2_HUMAN
NC score	0.902103 (rank : 234)	θ value	4.91457e-14 (rank : 289)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	777
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K1_HUMAN
NC score	0.901587 (rank : 235)	θ value	8.38298e-14 (rank : 301)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	774
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

STK4_HUMAN
NC score	0.901521 (rank : 236)	θ value	8.10077e-17 (rank : 169)
Query Neighborhood Hits	1044	Target Neighborhood Hits	870	Shared Neighborhood Hits	785
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

PFTK1_MOUSE
NC score	0.901473 (rank : 237)	θ value	1.24977e-17 (rank : 144)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	769
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

STK4_MOUSE
NC score	0.901470 (rank : 238)	θ value	8.10077e-17 (rank : 170)
Query Neighborhood Hits	1044	Target Neighborhood Hits	873	Shared Neighborhood Hits	785
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

MP2K1_MOUSE
NC score	0.901341 (rank : 239)	θ value	1.42992e-13 (rank : 312)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	774
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_MOUSE
NC score	0.901225 (rank : 240)	θ value	3.18553e-13 (rank : 331)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	776
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

STK3_MOUSE
NC score	0.901070 (rank : 241)	θ value	1.52774e-15 (rank : 210)
Query Neighborhood Hits	1044	Target Neighborhood Hits	869	Shared Neighborhood Hits	783
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

CDKL5_HUMAN
NC score	0.901052 (rank : 242)	θ value	1.9326e-10 (rank : 460)
Query Neighborhood Hits	1044	Target Neighborhood Hits	967	Shared Neighborhood Hits	784
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

SGK3_MOUSE
NC score	0.900957 (rank : 243)	θ value	1.09232e-21 (rank : 43)
Query Neighborhood Hits	1044	Target Neighborhood Hits	882	Shared Neighborhood Hits	778
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SGK3_HUMAN
NC score	0.900824 (rank : 244)	θ value	1.42661e-21 (rank : 46)
Query Neighborhood Hits	1044	Target Neighborhood Hits	877	Shared Neighborhood Hits	778
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

STK3_HUMAN
NC score	0.900823 (rank : 245)	θ value	2.60593e-15 (rank : 223)
Query Neighborhood Hits	1044	Target Neighborhood Hits	861	Shared Neighborhood Hits	785
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

CDKL2_HUMAN
NC score	0.900780 (rank : 246)	θ value	1.9326e-10 (rank : 459)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	778
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

PFTK1_HUMAN
NC score	0.900757 (rank : 247)	θ value	6.20254e-17 (rank : 163)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	767
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KS6A4_MOUSE
NC score	0.900562 (rank : 248)	θ value	7.58209e-15 (rank : 249)
Query Neighborhood Hits	1044	Target Neighborhood Hits	866	Shared Neighborhood Hits	782
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

AKT2_HUMAN
NC score	0.900440 (rank : 249)	θ value	3.75424e-22 (rank : 30)
Query Neighborhood Hits	1044	Target Neighborhood Hits	878	Shared Neighborhood Hits	781
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

CAMKV_MOUSE
NC score	0.899891 (rank : 250)	θ value	8.65492e-19 (rank : 106)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	723
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

E2AK2_HUMAN
NC score	0.899796 (rank : 251)	θ value	7.59969e-07 (rank : 633)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	777
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

KS6B2_MOUSE
NC score	0.899757 (rank : 252)	θ value	1.68911e-14 (rank : 268)
Query Neighborhood Hits	1044	Target Neighborhood Hits	871	Shared Neighborhood Hits	776
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

AKT2_MOUSE
NC score	0.899688 (rank : 253)	θ value	1.42661e-21 (rank : 44)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	778
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

KS6A4_HUMAN
NC score	0.899556 (rank : 254)	θ value	6.41864e-14 (rank : 294)
Query Neighborhood Hits	1044	Target Neighborhood Hits	868	Shared Neighborhood Hits	782
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

CDK3_MOUSE
NC score	0.899545 (rank : 255)	θ value	1.38499e-08 (rank : 548)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	773
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

ICK_MOUSE
NC score	0.899490 (rank : 256)	θ value	3.76295e-14 (rank : 284)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	777
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

PCTK3_MOUSE
NC score	0.899066 (rank : 257)	θ value	1.058e-16 (rank : 178)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	771
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CDK3_HUMAN
NC score	0.899063 (rank : 258)	θ value	1.58096e-12 (rank : 369)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	777
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK2_HUMAN
NC score	0.899029 (rank : 259)	θ value	7.09661e-13 (rank : 350)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	775
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

ICK_HUMAN
NC score	0.898871 (rank : 260)	θ value	2.20605e-14 (rank : 276)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	776
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

AKT1_MOUSE
NC score	0.898837 (rank : 261)	θ value	8.36355e-22 (rank : 36)
Query Neighborhood Hits	1044	Target Neighborhood Hits	878	Shared Neighborhood Hits	784
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT1_HUMAN
NC score	0.898799 (rank : 262)	θ value	2.87452e-22 (rank : 27)
Query Neighborhood Hits	1044	Target Neighborhood Hits	885	Shared Neighborhood Hits	784
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

KS6A5_MOUSE
NC score	0.898698 (rank : 263)	θ value	9.90251e-15 (rank : 261)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	780
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MP2K5_MOUSE
NC score	0.898574 (rank : 264)	θ value	2.88119e-14 (rank : 282)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	781
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

YSK4_HUMAN
NC score	0.897973 (rank : 265)	θ value	1.33837e-11 (rank : 414)
Query Neighborhood Hits	1044	Target Neighborhood Hits	921	Shared Neighborhood Hits	788
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

CDK2_MOUSE
NC score	0.897429 (rank : 266)	θ value	2.69671e-12 (rank : 379)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	773
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

PCTK3_HUMAN
NC score	0.897424 (rank : 267)	θ value	4.74913e-17 (rank : 158)
Query Neighborhood Hits	1044	Target Neighborhood Hits	827	Shared Neighborhood Hits	768
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

MK12_MOUSE
NC score	0.897413 (rank : 268)	θ value	2.13179e-17 (rank : 151)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	774
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PCTK1_HUMAN
NC score	0.897256 (rank : 269)	θ value	7.58209e-15 (rank : 254)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	770
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

MK15_HUMAN
NC score	0.897036 (rank : 270)	θ value	3.40345e-15 (rank : 228)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1038	Shared Neighborhood Hits	769
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

PCTK1_MOUSE
NC score	0.896988 (rank : 271)	θ value	9.90251e-15 (rank : 262)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	770
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

NEK9_MOUSE
NC score	0.896706 (rank : 272)	θ value	1.42992e-13 (rank : 314)
Query Neighborhood Hits	1044	Target Neighborhood Hits	890	Shared Neighborhood Hits	786
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NEK9_HUMAN
NC score	0.896545 (rank : 273)	θ value	1.42992e-13 (rank : 313)
Query Neighborhood Hits	1044	Target Neighborhood Hits	900	Shared Neighborhood Hits	784
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

MK12_HUMAN
NC score	0.896514 (rank : 274)	θ value	3.07829e-16 (rank : 187)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	773
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

STK24_HUMAN
NC score	0.896472 (rank : 275)	θ value	5.43371e-13 (rank : 348)
Query Neighborhood Hits	1044	Target Neighborhood Hits	853	Shared Neighborhood Hits	783
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

PCTK2_HUMAN
NC score	0.896362 (rank : 276)	θ value	5.60996e-18 (rank : 136)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	772
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

STK35_HUMAN
NC score	0.896183 (rank : 277)	θ value	4.30538e-10 (rank : 481)
Query Neighborhood Hits	1044	Target Neighborhood Hits	825	Shared Neighborhood Hits	771
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

MK15_MOUSE
NC score	0.896128 (rank : 278)	θ value	5.25075e-16 (rank : 199)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	767
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

PCTK2_MOUSE
NC score	0.896115 (rank : 279)	θ value	5.60996e-18 (rank : 137)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	772
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MAK_MOUSE
NC score	0.895901 (rank : 280)	θ value	2.69671e-12 (rank : 385)
Query Neighborhood Hits	1044	Target Neighborhood Hits	873	Shared Neighborhood Hits	776
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

STK24_MOUSE
NC score	0.895672 (rank : 281)	θ value	1.58096e-12 (rank : 372)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	783
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

KGP2_HUMAN
NC score	0.895509 (rank : 282)	θ value	6.85773e-16 (rank : 202)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1023	Shared Neighborhood Hits	843
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

MAPK5_MOUSE
NC score	0.894955 (rank : 283)	θ value	3.76295e-14 (rank : 285)
Query Neighborhood Hits	1044	Target Neighborhood Hits	799	Shared Neighborhood Hits	749
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

AL2S7_HUMAN
NC score	0.894905 (rank : 284)	θ value	8.10077e-17 (rank : 167)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	767
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

MP2K7_HUMAN
NC score	0.894888 (rank : 285)	θ value	1.63604e-09 (rank : 513)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	773
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MAPK5_HUMAN
NC score	0.894553 (rank : 286)	θ value	2.20605e-14 (rank : 277)
Query Neighborhood Hits	1044	Target Neighborhood Hits	795	Shared Neighborhood Hits	747
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAK_HUMAN
NC score	0.894500 (rank : 287)	θ value	2.69671e-12 (rank : 384)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	775
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MK14_MOUSE
NC score	0.894334 (rank : 288)	θ value	6.20254e-17 (rank : 159)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	776
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

CD2L5_HUMAN
NC score	0.894292 (rank : 289)	θ value	8.65492e-19 (rank : 107)
Query Neighborhood Hits	1044	Target Neighborhood Hits	987	Shared Neighborhood Hits	778
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

MK14_HUMAN
NC score	0.894201 (rank : 290)	θ value	1.058e-16 (rank : 175)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	776
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

CD2L5_MOUSE
NC score	0.893917 (rank : 291)	θ value	8.65492e-19 (rank : 108)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1011	Shared Neighborhood Hits	775
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

KGP2_MOUSE
NC score	0.893849 (rank : 292)	θ value	2.60593e-15 (rank : 219)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1029	Shared Neighborhood Hits	840
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

CDK5_HUMAN
NC score	0.893139 (rank : 293)	θ value	3.40345e-15 (rank : 224)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	767
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CAMKV_HUMAN
NC score	0.893114 (rank : 294)	θ value	8.65492e-19 (rank : 105)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1084	Shared Neighborhood Hits	726
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

OXSR1_HUMAN
NC score	0.893006 (rank : 295)	θ value	5.62301e-10 (rank : 492)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	782
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
NC score	0.892998 (rank : 296)	θ value	7.34386e-10 (rank : 496)
Query Neighborhood Hits	1044	Target Neighborhood Hits	865	Shared Neighborhood Hits	783
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

CDK5_MOUSE
NC score	0.892995 (rank : 297)	θ value	3.40345e-15 (rank : 225)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	767
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

STK25_HUMAN
NC score	0.892867 (rank : 298)	θ value	1.25267e-09 (rank : 507)
Query Neighborhood Hits	1044	Target Neighborhood Hits	853	Shared Neighborhood Hits	782
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

CDK6_MOUSE
NC score	0.892815 (rank : 299)	θ value	7.58209e-15 (rank : 246)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	770
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

MP2K5_HUMAN
NC score	0.892665 (rank : 300)	θ value	1.02475e-11 (rank : 409)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	777
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MST4_MOUSE
NC score	0.892562 (rank : 301)	θ value	1.25267e-09 (rank : 506)
Query Neighborhood Hits	1044	Target Neighborhood Hits	860	Shared Neighborhood Hits	782
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.892551 (rank : 302)	θ value	9.59137e-10 (rank : 501)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	782
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

WNK3_HUMAN
NC score	0.892403 (rank : 303)	θ value	7.82807e-20 (rank : 78)
Query Neighborhood Hits	1044	Target Neighborhood Hits	948	Shared Neighborhood Hits	745
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

GRK7_HUMAN
NC score	0.892305 (rank : 304)	θ value	2.28291e-11 (rank : 422)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	772
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

CD2L7_HUMAN
NC score	0.892283 (rank : 305)	θ value	8.65492e-19 (rank : 109)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1275	Shared Neighborhood Hits	797
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

STK39_HUMAN
NC score	0.892219 (rank : 306)	θ value	7.34386e-10 (rank : 497)
Query Neighborhood Hits	1044	Target Neighborhood Hits	882	Shared Neighborhood Hits	784
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK25_MOUSE
NC score	0.892207 (rank : 307)	θ value	1.63604e-09 (rank : 517)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	782
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

CCRK_HUMAN
NC score	0.892071 (rank : 308)	θ value	4.91457e-14 (rank : 286)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	776
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

STK39_MOUSE
NC score	0.891958 (rank : 309)	θ value	7.34386e-10 (rank : 498)
Query Neighborhood Hits	1044	Target Neighborhood Hits	915	Shared Neighborhood Hits	786
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

M3K14_HUMAN
NC score	0.891915 (rank : 310)	θ value	2.44474e-05 (rank : 680)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	764
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

CDK6_HUMAN
NC score	0.891782 (rank : 311)	θ value	9.90251e-15 (rank : 256)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	770
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

MAST3_HUMAN
NC score	0.891492 (rank : 312)	θ value	5.25075e-16 (rank : 198)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1128	Shared Neighborhood Hits	786
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MK13_MOUSE
NC score	0.891173 (rank : 313)	θ value	3.18553e-13 (rank : 330)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	775
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK13_HUMAN
NC score	0.890696 (rank : 314)	θ value	2.43908e-13 (rank : 323)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	774
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

CCRK_MOUSE
NC score	0.890492 (rank : 315)	θ value	1.58096e-12 (rank : 367)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	774
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

MAST2_MOUSE
NC score	0.890363 (rank : 316)	θ value	5.8054e-15 (rank : 239)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1110	Shared Neighborhood Hits	787
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

STK16_HUMAN
NC score	0.889258 (rank : 317)	θ value	4.92598e-06 (rank : 662)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	767
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

STK16_MOUSE
NC score	0.888917 (rank : 318)	θ value	1.69304e-06 (rank : 647)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	765
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

MAST2_HUMAN
NC score	0.888895 (rank : 319)	θ value	4.44505e-15 (rank : 234)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1189	Shared Neighborhood Hits	788
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MK04_HUMAN
NC score	0.888679 (rank : 320)	θ value	1.47631e-18 (rank : 126)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	767
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK03_HUMAN
NC score	0.888401 (rank : 321)	θ value	5.8054e-15 (rank : 241)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	777
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MASTL_HUMAN
NC score	0.888197 (rank : 322)	θ value	2.13673e-09 (rank : 523)
Query Neighborhood Hits	1044	Target Neighborhood Hits	894	Shared Neighborhood Hits	778
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MK03_MOUSE
NC score	0.888114 (rank : 323)	θ value	7.58209e-15 (rank : 252)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	777
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

RK_MOUSE
NC score	0.888101 (rank : 324)	θ value	1.02475e-11 (rank : 411)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	773
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MK11_MOUSE
NC score	0.887178 (rank : 325)	θ value	1.09485e-13 (rank : 309)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	771
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

SLK_MOUSE
NC score	0.886902 (rank : 326)	θ value	7.32683e-18 (rank : 141)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1798	Shared Neighborhood Hits	953
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

KPCI_HUMAN
NC score	0.886756 (rank : 327)	θ value	4.44505e-15 (rank : 231)
Query Neighborhood Hits	1044	Target Neighborhood Hits	885	Shared Neighborhood Hits	777
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

NLK_HUMAN
NC score	0.886755 (rank : 328)	θ value	1.133e-10 (rank : 448)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	775
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
NC score	0.886740 (rank : 329)	θ value	1.133e-10 (rank : 449)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	775
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

MK04_MOUSE
NC score	0.886651 (rank : 330)	θ value	1.63225e-17 (rank : 145)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	763
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

KPCI_MOUSE
NC score	0.886546 (rank : 331)	θ value	4.44505e-15 (rank : 232)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	777
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

MASTL_MOUSE
NC score	0.886543 (rank : 332)	θ value	3.64472e-09 (rank : 530)
Query Neighborhood Hits	1044	Target Neighborhood Hits	862	Shared Neighborhood Hits	779
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

PKN2_MOUSE
NC score	0.886458 (rank : 333)	θ value	6.00763e-12 (rank : 398)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	793
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_HUMAN
NC score	0.886439 (rank : 334)	θ value	4.59992e-12 (rank : 396)
Query Neighborhood Hits	1044	Target Neighborhood Hits	892	Shared Neighborhood Hits	794
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

M3K8_MOUSE
NC score	0.886363 (rank : 335)	θ value	5.26297e-08 (rank : 584)
Query Neighborhood Hits	1044	Target Neighborhood Hits	815	Shared Neighborhood Hits	752
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

KPCT_HUMAN
NC score	0.886286 (rank : 336)	θ value	1.02475e-11 (rank : 408)
Query Neighborhood Hits	1044	Target Neighborhood Hits	897	Shared Neighborhood Hits	781
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MAST1_MOUSE
NC score	0.886214 (rank : 337)	θ value	2.60593e-15 (rank : 222)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1123	Shared Neighborhood Hits	787
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

M3K14_MOUSE
NC score	0.886108 (rank : 338)	θ value	0.000602161 (rank : 714)
Query Neighborhood Hits	1044	Target Neighborhood Hits	889	Shared Neighborhood Hits	754
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MAST1_HUMAN
NC score	0.886089 (rank : 339)	θ value	5.25075e-16 (rank : 197)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1146	Shared Neighborhood Hits	788
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

M3K8_HUMAN
NC score	0.885847 (rank : 340)	θ value	5.81887e-07 (rank : 630)
Query Neighborhood Hits	1044	Target Neighborhood Hits	807	Shared Neighborhood Hits	751
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

SLK_HUMAN
NC score	0.885682 (rank : 341)	θ value	1.63225e-17 (rank : 146)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1775	Shared Neighborhood Hits	956
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

KPCT_MOUSE
NC score	0.885564 (rank : 342)	θ value	5.43371e-13 (rank : 345)
Query Neighborhood Hits	1044	Target Neighborhood Hits	895	Shared Neighborhood Hits	779
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

RK_HUMAN
NC score	0.885442 (rank : 343)	θ value	1.47974e-10 (rank : 457)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	775
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MP2K4_HUMAN
NC score	0.884820 (rank : 344)	θ value	1.2105e-12 (rank : 364)
Query Neighborhood Hits	1044	Target Neighborhood Hits	832	Shared Neighborhood Hits	776
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
NC score	0.884643 (rank : 345)	θ value	1.2105e-12 (rank : 365)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	776
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MK07_MOUSE
NC score	0.884618 (rank : 346)	θ value	5.08577e-11 (rank : 437)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1054	Shared Neighborhood Hits	786
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK01_MOUSE
NC score	0.884611 (rank : 347)	θ value	7.58209e-15 (rank : 251)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	773
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_HUMAN
NC score	0.884450 (rank : 348)	θ value	5.8054e-15 (rank : 240)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	773
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

CDK9_HUMAN
NC score	0.884325 (rank : 349)	θ value	7.84624e-12 (rank : 401)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	769
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

TAOK2_HUMAN
NC score	0.883967 (rank : 350)	θ value	8.38298e-14 (rank : 303)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1172	Shared Neighborhood Hits	893
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

CDK9_MOUSE
NC score	0.883865 (rank : 351)	θ value	7.84624e-12 (rank : 402)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	769
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

PKN3_HUMAN
NC score	0.883672 (rank : 352)	θ value	1.74796e-11 (rank : 419)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	787
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

CDK4_MOUSE
NC score	0.883640 (rank : 353)	θ value	8.67504e-11 (rank : 443)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	769
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

MK07_HUMAN
NC score	0.883558 (rank : 354)	θ value	5.08577e-11 (rank : 436)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1087	Shared Neighborhood Hits	783
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

GRK6_HUMAN
NC score	0.883388 (rank : 355)	θ value	8.11959e-09 (rank : 541)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	768
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KGP1A_HUMAN
NC score	0.883302 (rank : 356)	θ value	3.08544e-08 (rank : 568)
Query Neighborhood Hits	1044	Target Neighborhood Hits	901	Shared Neighborhood Hits	784
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

PKN1_MOUSE
NC score	0.883205 (rank : 357)	θ value	1.74796e-11 (rank : 418)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	788
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

M4K3_HUMAN
NC score	0.883169 (rank : 358)	θ value	3.64472e-09 (rank : 529)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	779
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

KPCE_MOUSE
NC score	0.883145 (rank : 359)	θ value	8.38298e-14 (rank : 300)
Query Neighborhood Hits	1044	Target Neighborhood Hits	906	Shared Neighborhood Hits	768
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCE_HUMAN
NC score	0.882969 (rank : 360)	θ value	1.2105e-12 (rank : 362)
Query Neighborhood Hits	1044	Target Neighborhood Hits	906	Shared Neighborhood Hits	769
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

WNK1_HUMAN
NC score	0.882893 (rank : 361)	θ value	1.74391e-19 (rank : 85)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1158	Shared Neighborhood Hits	752
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

ARBK2_HUMAN
NC score	0.882865 (rank : 362)	θ value	1.09485e-13 (rank : 305)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	773
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

KGP1B_MOUSE
NC score	0.882849 (rank : 363)	θ value	3.08544e-08 (rank : 570)
Query Neighborhood Hits	1044	Target Neighborhood Hits	922	Shared Neighborhood Hits	787
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

PKN3_MOUSE
NC score	0.882799 (rank : 364)	θ value	1.63604e-09 (rank : 514)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	806
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

KGP1B_HUMAN
NC score	0.882795 (rank : 365)	θ value	3.08544e-08 (rank : 569)
Query Neighborhood Hits	1044	Target Neighborhood Hits	921	Shared Neighborhood Hits	787
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

GRK6_MOUSE
NC score	0.882477 (rank : 366)	θ value	6.87365e-08 (rank : 594)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	768
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

PKN1_HUMAN
NC score	0.882440 (rank : 367)	θ value	1.74796e-11 (rank : 417)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	784
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

MK06_HUMAN
NC score	0.882409 (rank : 368)	θ value	8.36355e-22 (rank : 39)
Query Neighborhood Hits	1044	Target Neighborhood Hits	815	Shared Neighborhood Hits	749
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

CDK10_HUMAN
NC score	0.882066 (rank : 369)	θ value	1.74796e-11 (rank : 415)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	771
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

KPCL_MOUSE
NC score	0.882000 (rank : 370)	θ value	3.18553e-13 (rank : 329)
Query Neighborhood Hits	1044	Target Neighborhood Hits	891	Shared Neighborhood Hits	766
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

F5006_MOUSE
NC score	0.881947 (rank : 371)	θ value	0.000461057 (rank : 709)
Query Neighborhood Hits	1044	Target Neighborhood Hits	793	Shared Neighborhood Hits	746
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

MK06_MOUSE
NC score	0.881867 (rank : 372)	θ value	1.86321e-21 (rank : 47)
Query Neighborhood Hits	1044	Target Neighborhood Hits	818	Shared Neighborhood Hits	749
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

CDK4_HUMAN
NC score	0.881788 (rank : 373)	θ value	8.67504e-11 (rank : 442)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	769
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

M4K2_MOUSE
NC score	0.881737 (rank : 374)	θ value	5.08577e-11 (rank : 435)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	773
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

KPCZ_HUMAN
NC score	0.881711 (rank : 375)	θ value	1.29331e-14 (rank : 264)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	770
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
NC score	0.881672 (rank : 376)	θ value	1.29331e-14 (rank : 265)
Query Neighborhood Hits	1044	Target Neighborhood Hits	882	Shared Neighborhood Hits	770
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MK11_HUMAN
NC score	0.881377 (rank : 377)	θ value	1.2105e-12 (rank : 363)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	769
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

GSK3A_HUMAN
NC score	0.881302 (rank : 378)	θ value	4.45536e-07 (rank : 625)
Query Neighborhood Hits	1044	Target Neighborhood Hits	835	Shared Neighborhood Hits	755
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

ARBK1_HUMAN
NC score	0.881227 (rank : 379)	θ value	2.0648e-12 (rank : 373)
Query Neighborhood Hits	1044	Target Neighborhood Hits	859	Shared Neighborhood Hits	774
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

WNK1_MOUSE
NC score	0.881150 (rank : 380)	θ value	1.74391e-19 (rank : 86)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1179	Shared Neighborhood Hits	748
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

MP2K3_MOUSE
NC score	0.881100 (rank : 381)	θ value	3.08544e-08 (rank : 571)
Query Neighborhood Hits	1044	Target Neighborhood Hits	826	Shared Neighborhood Hits	774
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

M4K2_HUMAN
NC score	0.880748 (rank : 382)	θ value	3.29651e-10 (rank : 473)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	773
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

GRK5_MOUSE
NC score	0.880233 (rank : 383)	θ value	4.0297e-08 (rank : 576)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	763
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GSK3B_MOUSE
NC score	0.879900 (rank : 384)	θ value	4.0297e-08 (rank : 578)
Query Neighborhood Hits	1044	Target Neighborhood Hits	800	Shared Neighborhood Hits	752
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_HUMAN
NC score	0.879896 (rank : 385)	θ value	4.0297e-08 (rank : 577)
Query Neighborhood Hits	1044	Target Neighborhood Hits	801	Shared Neighborhood Hits	752
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

ARBK1_MOUSE
NC score	0.879882 (rank : 386)	θ value	2.0648e-12 (rank : 374)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	775
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

M4K1_MOUSE
NC score	0.879831 (rank : 387)	θ value	1.63604e-09 (rank : 512)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	781
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

GRK5_HUMAN
NC score	0.879821 (rank : 388)	θ value	4.0297e-08 (rank : 575)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	763
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KPCL_HUMAN
NC score	0.879637 (rank : 389)	θ value	5.08577e-11 (rank : 434)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	766
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MP2K6_MOUSE
NC score	0.879632 (rank : 390)	θ value	9.59137e-10 (rank : 500)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	775
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K6_HUMAN
NC score	0.879520 (rank : 391)	θ value	3.29651e-10 (rank : 474)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	774
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MP2K3_HUMAN
NC score	0.879476 (rank : 392)	θ value	5.26297e-08 (rank : 588)
Query Neighborhood Hits	1044	Target Neighborhood Hits	825	Shared Neighborhood Hits	774
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

M4K1_HUMAN
NC score	0.879169 (rank : 393)	θ value	1.06045e-08 (rank : 547)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	780
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

MK09_HUMAN
NC score	0.878638 (rank : 394)	θ value	2.36244e-08 (rank : 560)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	776
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

GRK4_HUMAN
NC score	0.878054 (rank : 395)	θ value	1.99992e-07 (rank : 608)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	764
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

ST38L_HUMAN
NC score	0.877449 (rank : 396)	θ value	1.99529e-15 (rank : 214)
Query Neighborhood Hits	1044	Target Neighborhood Hits	824	Shared Neighborhood Hits	759
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

CD2L6_HUMAN
NC score	0.877189 (rank : 397)	θ value	2.20605e-14 (rank : 273)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	766
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
NC score	0.877133 (rank : 398)	θ value	2.20605e-14 (rank : 274)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	767
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

KPCD_HUMAN
NC score	0.877113 (rank : 399)	θ value	4.76016e-09 (rank : 534)
Query Neighborhood Hits	1044	Target Neighborhood Hits	900	Shared Neighborhood Hits	775
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

WNK4_MOUSE
NC score	0.877049 (rank : 400)	θ value	1.16975e-15 (rank : 205)
Query Neighborhood Hits	1044	Target Neighborhood Hits	961	Shared Neighborhood Hits	730
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

STK38_MOUSE
NC score	0.876972 (rank : 401)	θ value	2.20605e-14 (rank : 279)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	770
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_HUMAN
NC score	0.876674 (rank : 402)	θ value	4.91457e-14 (rank : 291)
Query Neighborhood Hits	1044	Target Neighborhood Hits	840	Shared Neighborhood Hits	770
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

TAOK2_MOUSE
NC score	0.876129 (rank : 403)	θ value	8.38298e-14 (rank : 304)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1373	Shared Neighborhood Hits	927
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

CDK8_HUMAN
NC score	0.875389 (rank : 404)	θ value	4.91457e-14 (rank : 287)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	766
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

CD2L2_HUMAN
NC score	0.875355 (rank : 405)	θ value	2.0648e-12 (rank : 375)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1439	Shared Neighborhood Hits	885
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

MK08_MOUSE
NC score	0.875073 (rank : 406)	θ value	2.61198e-07 (rank : 611)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	773
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

MK09_MOUSE
NC score	0.875043 (rank : 407)	θ value	5.26297e-08 (rank : 587)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	773
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

CD2L1_MOUSE
NC score	0.874983 (rank : 408)	θ value	7.09661e-13 (rank : 349)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1463	Shared Neighborhood Hits	888
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

KPCD_MOUSE
NC score	0.874912 (rank : 409)	θ value	7.34386e-10 (rank : 494)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	772
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

GRK4_MOUSE
NC score	0.874745 (rank : 410)	θ value	3.08544e-08 (rank : 567)
Query Neighborhood Hits	1044	Target Neighborhood Hits	808	Shared Neighborhood Hits	758
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

WNK4_HUMAN
NC score	0.874625 (rank : 411)	θ value	2.35696e-16 (rank : 183)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1043	Shared Neighborhood Hits	723
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MAST4_HUMAN
NC score	0.874486 (rank : 412)	θ value	1.52774e-15 (rank : 208)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1804	Shared Neighborhood Hits	812
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MK08_HUMAN
NC score	0.874367 (rank : 413)	θ value	2.61198e-07 (rank : 610)
Query Neighborhood Hits	1044	Target Neighborhood Hits	834	Shared Neighborhood Hits	773
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

CD2L1_HUMAN
NC score	0.874351 (rank : 414)	θ value	1.58096e-12 (rank : 368)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1467	Shared Neighborhood Hits	892
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

HIPK4_HUMAN
NC score	0.874188 (rank : 415)	θ value	5.43371e-13 (rank : 344)
Query Neighborhood Hits	1044	Target Neighborhood Hits	799	Shared Neighborhood Hits	743
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

CSK21_MOUSE
NC score	0.873894 (rank : 416)	θ value	2.36244e-08 (rank : 559)
Query Neighborhood Hits	1044	Target Neighborhood Hits	770	Shared Neighborhood Hits	733
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

F5006_HUMAN
NC score	0.873759 (rank : 417)	θ value	0.00020696 (rank : 697)
Query Neighborhood Hits	1044	Target Neighborhood Hits	794	Shared Neighborhood Hits	739
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

CSK21_HUMAN
NC score	0.873582 (rank : 418)	θ value	3.08544e-08 (rank : 564)
Query Neighborhood Hits	1044	Target Neighborhood Hits	772	Shared Neighborhood Hits	735
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

M4K5_MOUSE
NC score	0.873342 (rank : 419)	θ value	3.41135e-07 (rank : 621)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	770
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MK10_HUMAN
NC score	0.872927 (rank : 420)	θ value	1.53129e-07 (rank : 604)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	772
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
NC score	0.872664 (rank : 421)	θ value	1.53129e-07 (rank : 605)
Query Neighborhood Hits	1044	Target Neighborhood Hits	849	Shared Neighborhood Hits	773
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

DMPK_MOUSE
NC score	0.872648 (rank : 422)	θ value	1.9326e-10 (rank : 461)
Query Neighborhood Hits	1044	Target Neighborhood Hits	908	Shared Neighborhood Hits	802
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

WNK2_HUMAN
NC score	0.872237 (rank : 423)	θ value	2.7842e-17 (rank : 156)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1407	Shared Neighborhood Hits	742
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

MOK_HUMAN
NC score	0.872133 (rank : 424)	θ value	5.43371e-13 (rank : 347)
Query Neighborhood Hits	1044	Target Neighborhood Hits	807	Shared Neighborhood Hits	750
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MOK_MOUSE
NC score	0.871721 (rank : 425)	θ value	1.86753e-13 (rank : 317)
Query Neighborhood Hits	1044	Target Neighborhood Hits	796	Shared Neighborhood Hits	748
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

DMPK_HUMAN
NC score	0.871682 (rank : 426)	θ value	1.63604e-09 (rank : 508)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	807
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

M4K5_HUMAN
NC score	0.871647 (rank : 427)	θ value	4.45536e-07 (rank : 627)
Query Neighborhood Hits	1044	Target Neighborhood Hits	845	Shared Neighborhood Hits	774
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

TAOK3_MOUSE
NC score	0.871591 (rank : 428)	θ value	7.58209e-15 (rank : 255)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1458	Shared Neighborhood Hits	943
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

TNIK_HUMAN
NC score	0.871580 (rank : 429)	θ value	1.9326e-10 (rank : 464)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1570	Shared Neighborhood Hits	919
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

ERN1_HUMAN
NC score	0.871091 (rank : 430)	θ value	6.87365e-08 (rank : 593)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	767
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CI096_HUMAN
NC score	0.870283 (rank : 431)	θ value	1.09739e-05 (rank : 671)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	750
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

TAOK3_HUMAN
NC score	0.870211 (rank : 432)	θ value	5.8054e-15 (rank : 243)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1494	Shared Neighborhood Hits	947
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

PMYT1_MOUSE
NC score	0.869459 (rank : 433)	θ value	0.813845 (rank : 886)
Query Neighborhood Hits	1044	Target Neighborhood Hits	910	Shared Neighborhood Hits	769
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

ST38L_MOUSE
NC score	0.869440 (rank : 434)	θ value	1.29331e-14 (rank : 267)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	752
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

CSKP_MOUSE
NC score	0.869378 (rank : 435)	θ value	2.60593e-15 (rank : 217)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1027	Shared Neighborhood Hits	769
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

MINK1_MOUSE
NC score	0.868808 (rank : 436)	θ value	5.26297e-08 (rank : 586)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1451	Shared Neighborhood Hits	911
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

E2AK3_MOUSE
NC score	0.868764 (rank : 437)	θ value	5.81887e-07 (rank : 629)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	776
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

E2AK3_HUMAN
NC score	0.868336 (rank : 438)	θ value	7.59969e-07 (rank : 634)
Query Neighborhood Hits	1044	Target Neighborhood Hits	859	Shared Neighborhood Hits	772
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

ERN1_MOUSE
NC score	0.868236 (rank : 439)	θ value	1.17247e-07 (rank : 600)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	766
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MINK1_HUMAN
NC score	0.868190 (rank : 440)	θ value	5.26297e-08 (rank : 585)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1477	Shared Neighborhood Hits	914
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

STK10_HUMAN
NC score	0.867842 (rank : 441)	θ value	2.69671e-12 (rank : 389)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1921	Shared Neighborhood Hits	972
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CSKP_HUMAN
NC score	0.866863 (rank : 442)	θ value	2.60593e-15 (rank : 216)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1022	Shared Neighborhood Hits	769
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

E2AK1_MOUSE
NC score	0.866431 (rank : 443)	θ value	0.00175202 (rank : 731)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	767
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

M3K13_HUMAN
NC score	0.863583 (rank : 444)	θ value	2.69671e-12 (rank : 382)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	786
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

ERN2_HUMAN
NC score	0.863520 (rank : 445)	θ value	8.11959e-09 (rank : 539)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	766
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

CSK22_HUMAN
NC score	0.863427 (rank : 446)	θ value	6.87365e-08 (rank : 592)
Query Neighborhood Hits	1044	Target Neighborhood Hits	758	Shared Neighborhood Hits	718
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_MOUSE
NC score	0.863175 (rank : 447)	θ value	1.99992e-07 (rank : 607)
Query Neighborhood Hits	1044	Target Neighborhood Hits	758	Shared Neighborhood Hits	718
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

E2AK1_HUMAN
NC score	0.862664 (rank : 448)	θ value	0.00228821 (rank : 736)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	772
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

ERN2_MOUSE
NC score	0.862531 (rank : 449)	θ value	5.62301e-10 (rank : 486)
Query Neighborhood Hits	1044	Target Neighborhood Hits	825	Shared Neighborhood Hits	767
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

TAOK1_MOUSE
NC score	0.861752 (rank : 450)	θ value	3.18553e-13 (rank : 334)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1720	Shared Neighborhood Hits	965
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK1_HUMAN
NC score	0.861384 (rank : 451)	θ value	4.16044e-13 (rank : 339)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1734	Shared Neighborhood Hits	965
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

KPCA_MOUSE
NC score	0.860965 (rank : 452)	θ value	3.18553e-13 (rank : 328)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1067	Shared Neighborhood Hits	774
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

DYR1B_MOUSE
NC score	0.860609 (rank : 453)	θ value	3.52202e-12 (rank : 392)
Query Neighborhood Hits	1044	Target Neighborhood Hits	799	Shared Neighborhood Hits	730
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

E2AK4_HUMAN
NC score	0.860579 (rank : 454)	θ value	1.29631e-06 (rank : 643)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1012	Shared Neighborhood Hits	817
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

STK40_HUMAN
NC score	0.860555 (rank : 455)	θ value	8.11959e-09 (rank : 543)
Query Neighborhood Hits	1044	Target Neighborhood Hits	751	Shared Neighborhood Hits	708
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

PMYT1_HUMAN
NC score	0.860300 (rank : 456)	θ value	θ > 10 (rank : 1318)
Query Neighborhood Hits	1044	Target Neighborhood Hits	814	Shared Neighborhood Hits	750
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

STK40_MOUSE
NC score	0.860219 (rank : 457)	θ value	8.11959e-09 (rank : 544)
Query Neighborhood Hits	1044	Target Neighborhood Hits	751	Shared Neighborhood Hits	708
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

KPCA_HUMAN
NC score	0.859890 (rank : 458)	θ value	3.18553e-13 (rank : 327)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1070	Shared Neighborhood Hits	777
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

LATS1_HUMAN
NC score	0.859795 (rank : 459)	θ value	1.09485e-13 (rank : 306)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1057	Shared Neighborhood Hits	791
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

BMP2K_HUMAN
NC score	0.859643 (rank : 460)	θ value	4.76016e-09 (rank : 533)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	747
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

M3K7_MOUSE
NC score	0.859420 (rank : 461)	θ value	7.09661e-13 (rank : 352)
Query Neighborhood Hits	1044	Target Neighborhood Hits	892	Shared Neighborhood Hits	794
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.859230 (rank : 462)	θ value	7.09661e-13 (rank : 351)
Query Neighborhood Hits	1044	Target Neighborhood Hits	892	Shared Neighborhood Hits	793
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

BMP2K_MOUSE
NC score	0.859085 (rank : 463)	θ value	1.80886e-08 (rank : 550)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	745
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

NRK_HUMAN
NC score	0.858934 (rank : 464)	θ value	4.92598e-06 (rank : 660)
Query Neighborhood Hits	1044	Target Neighborhood Hits	931	Shared Neighborhood Hits	783
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

DYRK3_HUMAN
NC score	0.858926 (rank : 465)	θ value	7.34386e-10 (rank : 493)
Query Neighborhood Hits	1044	Target Neighborhood Hits	798	Shared Neighborhood Hits	742
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

LATS2_HUMAN
NC score	0.858534 (rank : 466)	θ value	6.41864e-14 (rank : 295)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	765
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

M4K4_HUMAN
NC score	0.858317 (rank : 467)	θ value	8.40245e-06 (rank : 669)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1589	Shared Neighborhood Hits	926
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

DYRK2_HUMAN
NC score	0.858048 (rank : 468)	θ value	1.25267e-09 (rank : 504)
Query Neighborhood Hits	1044	Target Neighborhood Hits	799	Shared Neighborhood Hits	742
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

LATS1_MOUSE
NC score	0.857926 (rank : 469)	θ value	1.09485e-13 (rank : 307)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1027	Shared Neighborhood Hits	786
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

DYR1B_HUMAN
NC score	0.857770 (rank : 470)	θ value	7.84624e-12 (rank : 403)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	729
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

LATS2_MOUSE
NC score	0.857594 (rank : 471)	θ value	9.26847e-13 (rank : 357)
Query Neighborhood Hits	1044	Target Neighborhood Hits	879	Shared Neighborhood Hits	769
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

GAK_HUMAN
NC score	0.857205 (rank : 472)	θ value	8.67504e-11 (rank : 444)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1028	Shared Neighborhood Hits	771
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

NRK_MOUSE
NC score	0.856995 (rank : 473)	θ value	4.92598e-06 (rank : 661)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	781
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

E2AK4_MOUSE
NC score	0.856268 (rank : 474)	θ value	9.92553e-07 (rank : 640)
Query Neighborhood Hits	1044	Target Neighborhood Hits	984	Shared Neighborhood Hits	805
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

MRCKG_HUMAN
NC score	0.855093 (rank : 475)	θ value	1.02475e-11 (rank : 410)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1519	Shared Neighborhood Hits	916
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
NC score	0.854659 (rank : 476)	θ value	1.47974e-10 (rank : 455)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1466	Shared Neighborhood Hits	928
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MKNK1_HUMAN
NC score	0.854529 (rank : 477)	θ value	2.69671e-12 (rank : 386)
Query Neighborhood Hits	1044	Target Neighborhood Hits	701	Shared Neighborhood Hits	670
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

IRAK4_MOUSE
NC score	0.853367 (rank : 478)	θ value	4.0297e-08 (rank : 579)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	755
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

M3K12_MOUSE
NC score	0.852796 (rank : 479)	θ value	2.98157e-11 (rank : 427)
Query Neighborhood Hits	1044	Target Neighborhood Hits	957	Shared Neighborhood Hits	786
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
NC score	0.852706 (rank : 480)	θ value	2.98157e-11 (rank : 426)
Query Neighborhood Hits	1044	Target Neighborhood Hits	940	Shared Neighborhood Hits	785
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

GAK_MOUSE
NC score	0.852123 (rank : 481)	θ value	4.30538e-10 (rank : 478)
Query Neighborhood Hits	1044	Target Neighborhood Hits	964	Shared Neighborhood Hits	761
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

KPCG_MOUSE
NC score	0.851155 (rank : 482)	θ value	5.62301e-10 (rank : 490)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1123	Shared Neighborhood Hits	772
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCB_HUMAN
NC score	0.850996 (rank : 483)	θ value	3.52202e-12 (rank : 394)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1121	Shared Neighborhood Hits	778
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
NC score	0.850967 (rank : 484)	θ value	2.98157e-11 (rank : 425)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1117	Shared Neighborhood Hits	778
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCG_HUMAN
NC score	0.850769 (rank : 485)	θ value	7.34386e-10 (rank : 495)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1126	Shared Neighborhood Hits	772
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

M4K4_MOUSE
NC score	0.850736 (rank : 486)	θ value	0.00020696 (rank : 701)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1560	Shared Neighborhood Hits	921
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

AAK1_MOUSE
NC score	0.849980 (rank : 487)	θ value	5.26297e-08 (rank : 582)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1051	Shared Neighborhood Hits	755
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_HUMAN
NC score	0.849645 (rank : 488)	θ value	5.26297e-08 (rank : 581)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1077	Shared Neighborhood Hits	754
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

RIPK1_HUMAN
NC score	0.849580 (rank : 489)	θ value	5.08577e-11 (rank : 438)
Query Neighborhood Hits	1044	Target Neighborhood Hits	891	Shared Neighborhood Hits	783
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

STK10_MOUSE
NC score	0.849540 (rank : 490)	θ value	1.58096e-12 (rank : 371)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2132	Shared Neighborhood Hits	984
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

IRAK4_HUMAN
NC score	0.847898 (rank : 491)	θ value	1.17247e-07 (rank : 601)
Query Neighborhood Hits	1044	Target Neighborhood Hits	816	Shared Neighborhood Hits	755
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

RIPK3_MOUSE
NC score	0.847891 (rank : 492)	θ value	9.59137e-10 (rank : 503)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	755
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

MYLK_HUMAN
NC score	0.847642 (rank : 493)	θ value	2.7842e-17 (rank : 155)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1328	Shared Neighborhood Hits	779
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

DYR1A_HUMAN
NC score	0.847171 (rank : 494)	θ value	3.52202e-12 (rank : 390)
Query Neighborhood Hits	1044	Target Neighborhood Hits	764	Shared Neighborhood Hits	719
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
NC score	0.847170 (rank : 495)	θ value	3.52202e-12 (rank : 391)
Query Neighborhood Hits	1044	Target Neighborhood Hits	762	Shared Neighborhood Hits	719
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

HIPK3_MOUSE
NC score	0.847051 (rank : 496)	θ value	5.62301e-10 (rank : 489)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	748
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK1_HUMAN
NC score	0.845557 (rank : 497)	θ value	5.62301e-10 (rank : 487)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	739
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.845551 (rank : 498)	θ value	5.62301e-10 (rank : 488)
Query Neighborhood Hits	1044	Target Neighborhood Hits	838	Shared Neighborhood Hits	740
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

HIPK3_HUMAN
NC score	0.845179 (rank : 499)	θ value	4.30538e-10 (rank : 479)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	747
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

MYLK_MOUSE
NC score	0.844418 (rank : 500)	θ value	8.10077e-17 (rank : 168)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1489	Shared Neighborhood Hits	782
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

RIPK1_MOUSE
NC score	0.842369 (rank : 501)	θ value	1.80886e-08 (rank : 554)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	778
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TRIO_HUMAN
NC score	0.842204 (rank : 502)	θ value	7.09661e-13 (rank : 354)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1580	Shared Neighborhood Hits	886
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

RAF1_HUMAN
NC score	0.842097 (rank : 503)	θ value	1.9326e-10 (rank : 463)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	781
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

HIPK2_HUMAN
NC score	0.841790 (rank : 504)	θ value	2.13673e-09 (rank : 520)
Query Neighborhood Hits	1044	Target Neighborhood Hits	845	Shared Neighborhood Hits	741
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

RAF1_MOUSE
NC score	0.841727 (rank : 505)	θ value	3.29651e-10 (rank : 476)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	781
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

WEE1_MOUSE
NC score	0.841530 (rank : 506)	θ value	6.43352e-06 (rank : 668)
Query Neighborhood Hits	1044	Target Neighborhood Hits	794	Shared Neighborhood Hits	720
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

HIPK2_MOUSE
NC score	0.841446 (rank : 507)	θ value	2.13673e-09 (rank : 521)
Query Neighborhood Hits	1044	Target Neighborhood Hits	871	Shared Neighborhood Hits	741
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

DAPK1_HUMAN
NC score	0.841203 (rank : 508)	θ value	2.06002e-20 (rank : 62)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1130	Shared Neighborhood Hits	776
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DYRK4_HUMAN
NC score	0.840322 (rank : 509)	θ value	1.9326e-10 (rank : 462)
Query Neighborhood Hits	1044	Target Neighborhood Hits	750	Shared Neighborhood Hits	712
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

M3K9_HUMAN
NC score	0.840109 (rank : 510)	θ value	1.52774e-15 (rank : 207)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1123	Shared Neighborhood Hits	805
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K10_HUMAN
NC score	0.839924 (rank : 511)	θ value	2.60593e-15 (rank : 221)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1071	Shared Neighborhood Hits	800
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

RIPK3_HUMAN
NC score	0.838336 (rank : 512)	θ value	3.41135e-07 (rank : 622)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	753
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

BRAF1_HUMAN
NC score	0.837417 (rank : 513)	θ value	7.59969e-07 (rank : 632)
Query Neighborhood Hits	1044	Target Neighborhood Hits	883	Shared Neighborhood Hits	777
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

RIPK5_HUMAN
NC score	0.837383 (rank : 514)	θ value	0.00509761 (rank : 755)
Query Neighborhood Hits	1044	Target Neighborhood Hits	864	Shared Neighborhood Hits	783
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

DUET_HUMAN
NC score	0.837247 (rank : 515)	θ value	5.08577e-11 (rank : 431)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1220	Shared Neighborhood Hits	761
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DAPK1_MOUSE
NC score	0.837226 (rank : 516)	θ value	7.82807e-20 (rank : 73)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1138	Shared Neighborhood Hits	776
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

RIPK5_MOUSE
NC score	0.837176 (rank : 517)	θ value	0.00509761 (rank : 756)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	785
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

ARAF_HUMAN
NC score	0.836050 (rank : 518)	θ value	4.76016e-09 (rank : 532)
Query Neighborhood Hits	1044	Target Neighborhood Hits	924	Shared Neighborhood Hits	776
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

TESK2_MOUSE
NC score	0.836022 (rank : 519)	θ value	3.19293e-05 (rank : 683)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	763
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK2_HUMAN
NC score	0.835808 (rank : 520)	θ value	4.1701e-05 (rank : 686)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	765
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ARAF_MOUSE
NC score	0.835773 (rank : 521)	θ value	2.13673e-09 (rank : 518)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	775
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

TESK1_MOUSE
NC score	0.835667 (rank : 522)	θ value	0.00869519 (rank : 762)
Query Neighborhood Hits	1044	Target Neighborhood Hits	862	Shared Neighborhood Hits	753
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

M3K11_HUMAN
NC score	0.835555 (rank : 523)	θ value	4.16044e-13 (rank : 337)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1136	Shared Neighborhood Hits	789
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TESK1_HUMAN
NC score	0.833885 (rank : 524)	θ value	0.0148317 (rank : 776)
Query Neighborhood Hits	1044	Target Neighborhood Hits	864	Shared Neighborhood Hits	750
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

MLTK_MOUSE
NC score	0.833386 (rank : 525)	θ value	2.61198e-07 (rank : 613)
Query Neighborhood Hits	1044	Target Neighborhood Hits	874	Shared Neighborhood Hits	778
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

UHMK1_HUMAN
NC score	0.832992 (rank : 526)	θ value	6.43352e-06 (rank : 667)
Query Neighborhood Hits	1044	Target Neighborhood Hits	808	Shared Neighborhood Hits	727
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

MLTK_HUMAN
NC score	0.832836 (rank : 527)	θ value	2.61198e-07 (rank : 612)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	778
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MOS_HUMAN
NC score	0.831868 (rank : 528)	θ value	2.21117e-06 (rank : 650)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	773
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

UHMK1_MOUSE
NC score	0.831752 (rank : 529)	θ value	1.09739e-05 (rank : 675)
Query Neighborhood Hits	1044	Target Neighborhood Hits	809	Shared Neighborhood Hits	727
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

PRP4B_HUMAN
NC score	0.830432 (rank : 530)	θ value	6.43352e-06 (rank : 664)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1030	Shared Neighborhood Hits	763
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

MOS_MOUSE
NC score	0.830414 (rank : 531)	θ value	2.61198e-07 (rank : 614)
Query Neighborhood Hits	1044	Target Neighborhood Hits	833	Shared Neighborhood Hits	772
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

PRP4B_MOUSE
NC score	0.829844 (rank : 532)	θ value	6.43352e-06 (rank : 665)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1040	Shared Neighborhood Hits	773
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

SPEG_HUMAN
NC score	0.827498 (rank : 533)	θ value	6.00763e-12 (rank : 399)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1762	Shared Neighborhood Hits	790
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

WEE1_HUMAN
NC score	0.826372 (rank : 534)	θ value	1.87187e-05 (rank : 678)
Query Neighborhood Hits	1044	Target Neighborhood Hits	777	Shared Neighborhood Hits	699
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

M3KL4_HUMAN
NC score	0.823415 (rank : 535)	θ value	5.62301e-10 (rank : 491)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1087	Shared Neighborhood Hits	807
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SPEG_MOUSE
NC score	0.823047 (rank : 536)	θ value	1.58096e-12 (rank : 370)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1959	Shared Neighborhood Hits	792
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MRCKA_HUMAN
NC score	0.819025 (rank : 537)	θ value	9.26847e-13 (rank : 359)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1999	Shared Neighborhood Hits	965
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

CLK1_MOUSE
NC score	0.817592 (rank : 538)	θ value	2.21117e-06 (rank : 648)
Query Neighborhood Hits	1044	Target Neighborhood Hits	760	Shared Neighborhood Hits	715
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK1_HUMAN
NC score	0.817251 (rank : 539)	θ value	1.69304e-06 (rank : 645)
Query Neighborhood Hits	1044	Target Neighborhood Hits	756	Shared Neighborhood Hits	707
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

ROCK2_HUMAN
NC score	0.816954 (rank : 540)	θ value	1.74796e-11 (rank : 420)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2073	Shared Neighborhood Hits	969
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

CTRO_HUMAN
NC score	0.815378 (rank : 541)	θ value	1.02475e-11 (rank : 406)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2092	Shared Neighborhood Hits	959
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

WEE1B_HUMAN
NC score	0.814352 (rank : 542)	θ value	1.87187e-05 (rank : 677)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	698
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

ROCK1_HUMAN
NC score	0.814161 (rank : 543)	θ value	2.69671e-12 (rank : 387)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2000	Shared Neighborhood Hits	963
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

CLK4_HUMAN
NC score	0.813948 (rank : 544)	θ value	4.92598e-06 (rank : 659)
Query Neighborhood Hits	1044	Target Neighborhood Hits	759	Shared Neighborhood Hits	717
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

KSR2_HUMAN
NC score	0.813003 (rank : 545)	θ value	7.59969e-07 (rank : 637)
Query Neighborhood Hits	1044	Target Neighborhood Hits	920	Shared Neighborhood Hits	757
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

CLK4_MOUSE
NC score	0.812533 (rank : 546)	θ value	6.43352e-06 (rank : 663)
Query Neighborhood Hits	1044	Target Neighborhood Hits	759	Shared Neighborhood Hits	715
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

WEE1B_MOUSE
NC score	0.812340 (rank : 547)	θ value	0.00020696 (rank : 702)
Query Neighborhood Hits	1044	Target Neighborhood Hits	765	Shared Neighborhood Hits	699
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

ROCK2_MOUSE
NC score	0.810973 (rank : 548)	θ value	3.89403e-11 (rank : 429)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2072	Shared Neighborhood Hits	970
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

TRIB2_HUMAN
NC score	0.810916 (rank : 549)	θ value	2.88788e-06 (rank : 654)
Query Neighborhood Hits	1044	Target Neighborhood Hits	657	Shared Neighborhood Hits	622
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

CLK2_HUMAN
NC score	0.810726 (rank : 550)	θ value	9.92553e-07 (rank : 639)
Query Neighborhood Hits	1044	Target Neighborhood Hits	752	Shared Neighborhood Hits	705
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

TRIB2_MOUSE
NC score	0.810386 (rank : 551)	θ value	2.88788e-06 (rank : 655)
Query Neighborhood Hits	1044	Target Neighborhood Hits	653	Shared Neighborhood Hits	618
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

LIMK1_HUMAN
NC score	0.808621 (rank : 552)	θ value	0.00020696 (rank : 700)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1005	Shared Neighborhood Hits	771
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

MRCKB_MOUSE
NC score	0.808539 (rank : 553)	θ value	8.38298e-14 (rank : 302)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2180	Shared Neighborhood Hits	967
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

LIMK1_MOUSE
NC score	0.808139 (rank : 554)	θ value	4.1701e-05 (rank : 684)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1008	Shared Neighborhood Hits	771
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

OBSCN_HUMAN
NC score	0.806735 (rank : 555)	θ value	1.29331e-14 (rank : 266)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1931	Shared Neighborhood Hits	804
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

LIMK2_HUMAN
NC score	0.804385 (rank : 556)	θ value	θ > 10 (rank : 1230)
Query Neighborhood Hits	1044	Target Neighborhood Hits	986	Shared Neighborhood Hits	763
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MYO3A_MOUSE
NC score	0.803482 (rank : 557)	θ value	2.43908e-13 (rank : 325)
Query Neighborhood Hits	1044	Target Neighborhood Hits	902	Shared Neighborhood Hits	800
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

LIMK2_MOUSE
NC score	0.801572 (rank : 558)	θ value	θ > 10 (rank : 1231)
Query Neighborhood Hits	1044	Target Neighborhood Hits	998	Shared Neighborhood Hits	764
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

ROCK1_MOUSE
NC score	0.801286 (rank : 559)	θ value	2.69671e-12 (rank : 388)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2126	Shared Neighborhood Hits	972
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

MRCKB_HUMAN
NC score	0.801221 (rank : 560)	θ value	1.86753e-13 (rank : 318)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2239	Shared Neighborhood Hits	965
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

JAK2_HUMAN
NC score	0.798986 (rank : 561)	θ value	4.30538e-10 (rank : 480)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	772
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

CTRO_MOUSE
NC score	0.798744 (rank : 562)	θ value	4.16044e-13 (rank : 335)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2344	Shared Neighborhood Hits	963
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

RIPK2_HUMAN
NC score	0.798543 (rank : 563)	θ value	1.63604e-09 (rank : 515)
Query Neighborhood Hits	1044	Target Neighborhood Hits	774	Shared Neighborhood Hits	709
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

RIPK2_MOUSE
NC score	0.797839 (rank : 564)	θ value	2.52405e-10 (rank : 468)
Query Neighborhood Hits	1044	Target Neighborhood Hits	776	Shared Neighborhood Hits	709
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

JAK2_MOUSE
NC score	0.797759 (rank : 565)	θ value	5.08577e-11 (rank : 433)
Query Neighborhood Hits	1044	Target Neighborhood Hits	839	Shared Neighborhood Hits	768
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

CLK2_MOUSE
NC score	0.797664 (rank : 566)	θ value	1.09739e-05 (rank : 672)
Query Neighborhood Hits	1044	Target Neighborhood Hits	743	Shared Neighborhood Hits	700
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

MYO3A_HUMAN
NC score	0.797584 (rank : 567)	θ value	1.86753e-13 (rank : 319)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1033	Shared Neighborhood Hits	834
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

CLK3_HUMAN
NC score	0.794667 (rank : 568)	θ value	1.29631e-06 (rank : 641)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	703
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
NC score	0.793908 (rank : 569)	θ value	1.29631e-06 (rank : 642)
Query Neighborhood Hits	1044	Target Neighborhood Hits	761	Shared Neighborhood Hits	703
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

JAK3_MOUSE
NC score	0.792259 (rank : 570)	θ value	7.59969e-07 (rank : 635)
Query Neighborhood Hits	1044	Target Neighborhood Hits	821	Shared Neighborhood Hits	758
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

MYO3B_HUMAN
NC score	0.788496 (rank : 571)	θ value	9.59137e-10 (rank : 502)
Query Neighborhood Hits	1044	Target Neighborhood Hits	923	Shared Neighborhood Hits	806
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

JAK3_HUMAN
NC score	0.787213 (rank : 572)	θ value	4.45536e-07 (rank : 626)
Query Neighborhood Hits	1044	Target Neighborhood Hits	827	Shared Neighborhood Hits	766
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

KSR1_MOUSE
NC score	0.781493 (rank : 573)	θ value	2.44474e-05 (rank : 679)
Query Neighborhood Hits	1044	Target Neighborhood Hits	870	Shared Neighborhood Hits	749
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

TRIB1_HUMAN
NC score	0.781358 (rank : 574)	θ value	1.09739e-05 (rank : 674)
Query Neighborhood Hits	1044	Target Neighborhood Hits	598	Shared Neighborhood Hits	565
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
NC score	0.780781 (rank : 575)	θ value	3.77169e-06 (rank : 657)
Query Neighborhood Hits	1044	Target Neighborhood Hits	593	Shared Neighborhood Hits	569
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

FES_MOUSE
NC score	0.780525 (rank : 576)	θ value	8.11959e-09 (rank : 540)
Query Neighborhood Hits	1044	Target Neighborhood Hits	980	Shared Neighborhood Hits	798
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_HUMAN
NC score	0.779240 (rank : 577)	θ value	1.25267e-09 (rank : 505)
Query Neighborhood Hits	1044	Target Neighborhood Hits	978	Shared Neighborhood Hits	780
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

AL2S2_HUMAN
NC score	0.777543 (rank : 578)	θ value	8.99809 (rank : 1016)
Query Neighborhood Hits	1044	Target Neighborhood Hits	727	Shared Neighborhood Hits	676
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

JAK1_HUMAN
NC score	0.777125 (rank : 579)	θ value	1.17247e-07 (rank : 602)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	775
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

TYK2_HUMAN
NC score	0.775762 (rank : 580)	θ value	θ > 10 (rank : 1432)
Query Neighborhood Hits	1044	Target Neighborhood Hits	841	Shared Neighborhood Hits	769
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

PTK6_HUMAN
NC score	0.775458 (rank : 581)	θ value	3.08544e-08 (rank : 572)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1020	Shared Neighborhood Hits	774
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

KSYK_HUMAN
NC score	0.772786 (rank : 582)	θ value	4.44505e-15 (rank : 233)
Query Neighborhood Hits	1044	Target Neighborhood Hits	901	Shared Neighborhood Hits	761
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
NC score	0.772390 (rank : 583)	θ value	3.40345e-15 (rank : 227)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	762
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TYK2_MOUSE
NC score	0.772042 (rank : 584)	θ value	θ > 10 (rank : 1433)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	768
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

ZAP70_HUMAN
NC score	0.771661 (rank : 585)	θ value	1.058e-16 (rank : 179)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	763
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

PTK6_MOUSE
NC score	0.770959 (rank : 586)	θ value	1.17247e-07 (rank : 603)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1026	Shared Neighborhood Hits	774
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

JAK1_MOUSE
NC score	0.770220 (rank : 587)	θ value	3.41135e-07 (rank : 618)
Query Neighborhood Hits	1044	Target Neighborhood Hits	854	Shared Neighborhood Hits	773
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

IRAK1_HUMAN
NC score	0.769171 (rank : 588)	θ value	2.88788e-06 (rank : 652)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	702
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

TEC_MOUSE
NC score	0.769150 (rank : 589)	θ value	6.64225e-11 (rank : 441)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1006	Shared Neighborhood Hits	769
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ZAP70_MOUSE
NC score	0.769130 (rank : 590)	θ value	5.25075e-16 (rank : 200)
Query Neighborhood Hits	1044	Target Neighborhood Hits	905	Shared Neighborhood Hits	770
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

IRAK1_MOUSE
NC score	0.768372 (rank : 591)	θ value	2.21117e-06 (rank : 649)
Query Neighborhood Hits	1044	Target Neighborhood Hits	784	Shared Neighborhood Hits	700
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

FER_HUMAN
NC score	0.768318 (rank : 592)	θ value	3.29651e-10 (rank : 470)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1278	Shared Neighborhood Hits	870
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

KSR1_HUMAN
NC score	0.766551 (rank : 593)	θ value	0.000121331 (rank : 692)
Query Neighborhood Hits	1044	Target Neighborhood Hits	867	Shared Neighborhood Hits	738
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

PINK1_MOUSE
NC score	0.765410 (rank : 594)	θ value	0.00175202 (rank : 733)
Query Neighborhood Hits	1044	Target Neighborhood Hits	726	Shared Neighborhood Hits	676
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

AL2S2_MOUSE
NC score	0.763717 (rank : 595)	θ value	θ > 10 (rank : 1053)
Query Neighborhood Hits	1044	Target Neighborhood Hits	709	Shared Neighborhood Hits	660
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

FAK1_HUMAN
NC score	0.763320 (rank : 596)	θ value	6.64225e-11 (rank : 439)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	762
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
NC score	0.763240 (rank : 597)	θ value	5.08577e-11 (rank : 432)
Query Neighborhood Hits	1044	Target Neighborhood Hits	850	Shared Neighborhood Hits	763
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

TEC_HUMAN
NC score	0.763029 (rank : 598)	θ value	4.30538e-10 (rank : 482)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1006	Shared Neighborhood Hits	768
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
NC score	0.760375 (rank : 599)	θ value	1.47974e-10 (rank : 458)
Query Neighborhood Hits	1044	Target Neighborhood Hits	971	Shared Neighborhood Hits	764
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ITK_MOUSE
NC score	0.759840 (rank : 600)	θ value	2.0648e-12 (rank : 377)
Query Neighborhood Hits	1044	Target Neighborhood Hits	985	Shared Neighborhood Hits	774
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.759693 (rank : 601)	θ value	4.59992e-12 (rank : 395)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1016	Shared Neighborhood Hits	772
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

CSK_MOUSE
NC score	0.756591 (rank : 602)	θ value	0.00298849 (rank : 742)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	773
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

PINK1_HUMAN
NC score	0.755865 (rank : 603)	θ value	0.0252991 (rank : 787)
Query Neighborhood Hits	1044	Target Neighborhood Hits	741	Shared Neighborhood Hits	675
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

TRIB3_MOUSE
NC score	0.755589 (rank : 604)	θ value	0.163984 (rank : 830)
Query Neighborhood Hits	1044	Target Neighborhood Hits	578	Shared Neighborhood Hits	555
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

ABL1_MOUSE
NC score	0.755213 (rank : 605)	θ value	1.06045e-08 (rank : 545)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1178	Shared Neighborhood Hits	776
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FAK2_MOUSE
NC score	0.754690 (rank : 606)	θ value	6.64225e-11 (rank : 440)
Query Neighborhood Hits	1044	Target Neighborhood Hits	851	Shared Neighborhood Hits	755
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

ABL1_HUMAN
NC score	0.754669 (rank : 607)	θ value	8.11959e-09 (rank : 538)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1220	Shared Neighborhood Hits	774
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

LYN_MOUSE
NC score	0.754368 (rank : 608)	θ value	2.79066e-09 (rank : 526)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1023	Shared Neighborhood Hits	783
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_HUMAN
NC score	0.753932 (rank : 609)	θ value	2.13673e-09 (rank : 522)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1022	Shared Neighborhood Hits	783
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SRMS_MOUSE
NC score	0.753281 (rank : 610)	θ value	1.02475e-11 (rank : 412)
Query Neighborhood Hits	1044	Target Neighborhood Hits	964	Shared Neighborhood Hits	775
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

ABL2_HUMAN
NC score	0.753018 (rank : 611)	θ value	5.62301e-10 (rank : 483)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1045	Shared Neighborhood Hits	768
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

BTK_MOUSE
NC score	0.751586 (rank : 612)	θ value	2.36244e-08 (rank : 558)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1017	Shared Neighborhood Hits	760
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BTK_HUMAN
NC score	0.751536 (rank : 613)	θ value	2.36244e-08 (rank : 557)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1026	Shared Neighborhood Hits	759
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BMX_HUMAN
NC score	0.751173 (rank : 614)	θ value	8.97725e-08 (rank : 596)
Query Neighborhood Hits	1044	Target Neighborhood Hits	942	Shared Neighborhood Hits	753
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

FRK_HUMAN
NC score	0.750668 (rank : 615)	θ value	4.0297e-08 (rank : 574)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1058	Shared Neighborhood Hits	775
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FAK2_HUMAN
NC score	0.749039 (rank : 616)	θ value	2.52405e-10 (rank : 467)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	755
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

BMX_MOUSE
NC score	0.749011 (rank : 617)	θ value	7.59969e-07 (rank : 631)
Query Neighborhood Hits	1044	Target Neighborhood Hits	912	Shared Neighborhood Hits	743
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

MATK_MOUSE
NC score	0.748741 (rank : 618)	θ value	7.1131e-05 (rank : 691)
Query Neighborhood Hits	1044	Target Neighborhood Hits	952	Shared Neighborhood Hits	767
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

CSK_HUMAN
NC score	0.748704 (rank : 619)	θ value	0.00509761 (rank : 752)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	772
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

TXK_MOUSE
NC score	0.748259 (rank : 620)	θ value	1.9326e-10 (rank : 465)
Query Neighborhood Hits	1044	Target Neighborhood Hits	980	Shared Neighborhood Hits	756
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

LRRK1_HUMAN
NC score	0.746840 (rank : 621)	θ value	θ > 10 (rank : 1238)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1237	Shared Neighborhood Hits	752
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

SRMS_HUMAN
NC score	0.746573 (rank : 622)	θ value	2.13673e-09 (rank : 524)
Query Neighborhood Hits	1044	Target Neighborhood Hits	946	Shared Neighborhood Hits	771
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

LCK_MOUSE
NC score	0.746489 (rank : 623)	θ value	1.47974e-10 (rank : 454)
Query Neighborhood Hits	1044	Target Neighborhood Hits	981	Shared Neighborhood Hits	775
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LRRK2_HUMAN
NC score	0.745381 (rank : 624)	θ value	2.88788e-06 (rank : 653)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1382	Shared Neighborhood Hits	775
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

LRRK1_MOUSE
NC score	0.744915 (rank : 625)	θ value	θ > 10 (rank : 1239)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1267	Shared Neighborhood Hits	756
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

MATK_HUMAN
NC score	0.743462 (rank : 626)	θ value	0.000270298 (rank : 704)
Query Neighborhood Hits	1044	Target Neighborhood Hits	954	Shared Neighborhood Hits	766
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

FYN_HUMAN
NC score	0.741301 (rank : 627)	θ value	3.29651e-10 (rank : 471)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1078	Shared Neighborhood Hits	776
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

BLK_HUMAN
NC score	0.740914 (rank : 628)	θ value	3.08544e-08 (rank : 563)
Query Neighborhood Hits	1044	Target Neighborhood Hits	994	Shared Neighborhood Hits	775
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

LCK_HUMAN
NC score	0.740872 (rank : 629)	θ value	1.63604e-09 (rank : 510)
Query Neighborhood Hits	1044	Target Neighborhood Hits	987	Shared Neighborhood Hits	775
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

BLK_MOUSE
NC score	0.739015 (rank : 630)	θ value	1.17247e-07 (rank : 599)
Query Neighborhood Hits	1044	Target Neighborhood Hits	992	Shared Neighborhood Hits	774
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FYN_MOUSE
NC score	0.737011 (rank : 631)	θ value	4.30538e-10 (rank : 477)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1073	Shared Neighborhood Hits	779
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

EPHA5_MOUSE
NC score	0.736680 (rank : 632)	θ value	9.26847e-13 (rank : 356)
Query Neighborhood Hits	1044	Target Neighborhood Hits	950	Shared Neighborhood Hits	758
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

HCK_HUMAN
NC score	0.736267 (rank : 633)	θ value	1.38499e-08 (rank : 549)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1035	Shared Neighborhood Hits	773
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SRC_MOUSE
NC score	0.734109 (rank : 634)	θ value	2.36244e-08 (rank : 561)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1033	Shared Neighborhood Hits	767
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HCK_MOUSE
NC score	0.733512 (rank : 635)	θ value	2.13673e-09 (rank : 519)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1029	Shared Neighborhood Hits	774
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SRC_HUMAN
NC score	0.733427 (rank : 636)	θ value	1.80886e-08 (rank : 555)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1058	Shared Neighborhood Hits	770
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

EPHB1_HUMAN
NC score	0.731939 (rank : 637)	θ value	5.43371e-13 (rank : 343)
Query Neighborhood Hits	1044	Target Neighborhood Hits	988	Shared Neighborhood Hits	755
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

CDC7_HUMAN
NC score	0.730808 (rank : 638)	θ value	0.47712 (rank : 862)
Query Neighborhood Hits	1044	Target Neighborhood Hits	652	Shared Neighborhood Hits	615
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

TNI3K_MOUSE
NC score	0.729137 (rank : 639)	θ value	3.07829e-16 (rank : 191)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1079	Shared Neighborhood Hits	740
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

YES_HUMAN
NC score	0.728156 (rank : 640)	θ value	1.80886e-08 (rank : 556)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1059	Shared Neighborhood Hits	766
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

TTBK1_HUMAN
NC score	0.727950 (rank : 641)	θ value	0.0961366 (rank : 818)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1058	Shared Neighborhood Hits	683
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

YES_MOUSE
NC score	0.727677 (rank : 642)	θ value	2.36244e-08 (rank : 562)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1052	Shared Neighborhood Hits	768
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

KC1A_HUMAN
NC score	0.727676 (rank : 643)	θ value	3.41135e-07 (rank : 619)
Query Neighborhood Hits	1044	Target Neighborhood Hits	728	Shared Neighborhood Hits	700
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.727676 (rank : 644)	θ value	3.41135e-07 (rank : 620)
Query Neighborhood Hits	1044	Target Neighborhood Hits	728	Shared Neighborhood Hits	700
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1AL_HUMAN
NC score	0.726818 (rank : 645)	θ value	7.59969e-07 (rank : 636)
Query Neighborhood Hits	1044	Target Neighborhood Hits	734	Shared Neighborhood Hits	704
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

EPHA3_HUMAN
NC score	0.726682 (rank : 646)	θ value	2.88119e-14 (rank : 281)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1005	Shared Neighborhood Hits	761
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

LRRK2_MOUSE
NC score	0.725345 (rank : 647)	θ value	0.00298849 (rank : 743)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1359	Shared Neighborhood Hits	771
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

TRIB3_HUMAN
NC score	0.725018 (rank : 648)	θ value	θ > 10 (rank : 1423)
Query Neighborhood Hits	1044	Target Neighborhood Hits	519	Shared Neighborhood Hits	501
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

CDC7_MOUSE
NC score	0.724696 (rank : 649)	θ value	0.62314 (rank : 871)
Query Neighborhood Hits	1044	Target Neighborhood Hits	641	Shared Neighborhood Hits	615
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

TTBK2_HUMAN
NC score	0.724143 (rank : 650)	θ value	0.0252991 (rank : 790)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	675
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

FGR_HUMAN
NC score	0.723769 (rank : 651)	θ value	9.59137e-10 (rank : 499)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1067	Shared Neighborhood Hits	773
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ERBB4_HUMAN
NC score	0.723748 (rank : 652)	θ value	5.62301e-10 (rank : 485)
Query Neighborhood Hits	1044	Target Neighborhood Hits	910	Shared Neighborhood Hits	750
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

RET_HUMAN
NC score	0.723666 (rank : 653)	θ value	3.64472e-09 (rank : 531)
Query Neighborhood Hits	1044	Target Neighborhood Hits	873	Shared Neighborhood Hits	758
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

TNI3K_HUMAN
NC score	0.723645 (rank : 654)	θ value	4.02038e-16 (rank : 195)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1084	Shared Neighborhood Hits	745
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

EPHA7_MOUSE
NC score	0.722963 (rank : 655)	θ value	1.86753e-13 (rank : 315)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1025	Shared Neighborhood Hits	761
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

TNK1_MOUSE
NC score	0.722530 (rank : 656)	θ value	θ > 10 (rank : 1412)
Query Neighborhood Hits	1044	Target Neighborhood Hits	806	Shared Neighborhood Hits	726
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

RET_MOUSE
NC score	0.722469 (rank : 657)	θ value	1.80886e-08 (rank : 553)
Query Neighborhood Hits	1044	Target Neighborhood Hits	884	Shared Neighborhood Hits	755
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

EGFR_MOUSE
NC score	0.721860 (rank : 658)	θ value	4.0297e-08 (rank : 573)
Query Neighborhood Hits	1044	Target Neighborhood Hits	927	Shared Neighborhood Hits	759
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA7_HUMAN
NC score	0.721800 (rank : 659)	θ value	5.43371e-13 (rank : 342)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1053	Shared Neighborhood Hits	763
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

TTBK2_MOUSE
NC score	0.721452 (rank : 660)	θ value	0.0330416 (rank : 792)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	677
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

NTRK2_HUMAN
NC score	0.721278 (rank : 661)	θ value	8.67504e-11 (rank : 445)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1081	Shared Neighborhood Hits	758
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.721076 (rank : 662)	θ value	8.67504e-11 (rank : 446)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1088	Shared Neighborhood Hits	758
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

EGFR_HUMAN
NC score	0.721074 (rank : 663)	θ value	3.08544e-08 (rank : 565)
Query Neighborhood Hits	1044	Target Neighborhood Hits	939	Shared Neighborhood Hits	758
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

FGR_MOUSE
NC score	0.721046 (rank : 664)	θ value	6.21693e-09 (rank : 536)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1069	Shared Neighborhood Hits	771
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

EPHA5_HUMAN
NC score	0.720700 (rank : 665)	θ value	9.26847e-13 (rank : 355)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	761
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA3_MOUSE
NC score	0.720695 (rank : 666)	θ value	2.20605e-14 (rank : 275)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1009	Shared Neighborhood Hits	765
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA2_HUMAN
NC score	0.718703 (rank : 667)	θ value	2.0648e-12 (rank : 376)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1021	Shared Neighborhood Hits	762
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHB4_MOUSE
NC score	0.718300 (rank : 668)	θ value	1.06045e-08 (rank : 546)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1013	Shared Neighborhood Hits	750
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

TGFR2_MOUSE
NC score	0.718035 (rank : 669)	θ value	3.41135e-07 (rank : 624)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	698
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

RPKL1_MOUSE
NC score	0.718006 (rank : 670)	θ value	θ > 10 (rank : 1348)
Query Neighborhood Hits	1044	Target Neighborhood Hits	704	Shared Neighborhood Hits	626
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_HUMAN
NC score	0.717502 (rank : 671)	θ value	θ > 10 (rank : 1347)
Query Neighborhood Hits	1044	Target Neighborhood Hits	708	Shared Neighborhood Hits	630
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

TGFR2_HUMAN
NC score	0.717361 (rank : 672)	θ value	4.45536e-07 (rank : 628)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	697
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

EPHA2_MOUSE
NC score	0.716528 (rank : 673)	θ value	2.28291e-11 (rank : 421)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1020	Shared Neighborhood Hits	758
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHB2_MOUSE
NC score	0.715717 (rank : 674)	θ value	2.69671e-12 (rank : 381)
Query Neighborhood Hits	1044	Target Neighborhood Hits	982	Shared Neighborhood Hits	756
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.715560 (rank : 675)	θ value	2.69671e-12 (rank : 380)
Query Neighborhood Hits	1044	Target Neighborhood Hits	983	Shared Neighborhood Hits	756
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB4_HUMAN
NC score	0.714762 (rank : 676)	θ value	1.80886e-08 (rank : 551)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1056	Shared Neighborhood Hits	749
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

KS6C1_MOUSE
NC score	0.713805 (rank : 677)	θ value	0.365318 (rank : 857)
Query Neighborhood Hits	1044	Target Neighborhood Hits	700	Shared Neighborhood Hits	616
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

EPHA4_HUMAN
NC score	0.713765 (rank : 678)	θ value	5.43371e-13 (rank : 340)
Query Neighborhood Hits	1044	Target Neighborhood Hits	975	Shared Neighborhood Hits	755
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA1_HUMAN
NC score	0.713658 (rank : 679)	θ value	3.52202e-12 (rank : 393)
Query Neighborhood Hits	1044	Target Neighborhood Hits	997	Shared Neighborhood Hits	748
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA4_MOUSE
NC score	0.713466 (rank : 680)	θ value	5.43371e-13 (rank : 341)
Query Neighborhood Hits	1044	Target Neighborhood Hits	982	Shared Neighborhood Hits	755
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

ERBB2_MOUSE
NC score	0.713264 (rank : 681)	θ value	1.80886e-08 (rank : 552)
Query Neighborhood Hits	1044	Target Neighborhood Hits	918	Shared Neighborhood Hits	760
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

TNK1_HUMAN
NC score	0.713226 (rank : 682)	θ value	θ > 10 (rank : 1411)
Query Neighborhood Hits	1044	Target Neighborhood Hits	815	Shared Neighborhood Hits	723
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

RON_HUMAN
NC score	0.713147 (rank : 683)	θ value	2.61198e-07 (rank : 615)
Query Neighborhood Hits	1044	Target Neighborhood Hits	842	Shared Neighborhood Hits	753
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

AVR2A_MOUSE
NC score	0.712990 (rank : 684)	θ value	0.00102713 (rank : 720)
Query Neighborhood Hits	1044	Target Neighborhood Hits	767	Shared Neighborhood Hits	717
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.712980 (rank : 685)	θ value	0.00102713 (rank : 719)
Query Neighborhood Hits	1044	Target Neighborhood Hits	767	Shared Neighborhood Hits	717
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

EPHA8_HUMAN
NC score	0.710949 (rank : 686)	θ value	6.41864e-14 (rank : 293)
Query Neighborhood Hits	1044	Target Neighborhood Hits	956	Shared Neighborhood Hits	752
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

KC1D_HUMAN
NC score	0.709994 (rank : 687)	θ value	0.00020696 (rank : 698)
Query Neighborhood Hits	1044	Target Neighborhood Hits	737	Shared Neighborhood Hits	692
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.709982 (rank : 688)	θ value	0.00020696 (rank : 699)
Query Neighborhood Hits	1044	Target Neighborhood Hits	737	Shared Neighborhood Hits	692
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

ERBB2_HUMAN
NC score	0.709551 (rank : 689)	θ value	3.08544e-08 (rank : 566)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1073	Shared Neighborhood Hits	764
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

MET_MOUSE
NC score	0.708812 (rank : 690)	θ value	4.0297e-08 (rank : 580)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	747
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

KS6C1_HUMAN
NC score	0.708423 (rank : 691)	θ value	1.06291 (rank : 899)
Query Neighborhood Hits	1044	Target Neighborhood Hits	682	Shared Neighborhood Hits	618
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

ACK1_HUMAN
NC score	0.707273 (rank : 692)	θ value	θ > 10 (rank : 1049)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1140	Shared Neighborhood Hits	762
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

DDR2_MOUSE
NC score	0.707107 (rank : 693)	θ value	5.62301e-10 (rank : 484)
Query Neighborhood Hits	1044	Target Neighborhood Hits	813	Shared Neighborhood Hits	732
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

MET_HUMAN
NC score	0.706902 (rank : 694)	θ value	6.87365e-08 (rank : 595)
Query Neighborhood Hits	1044	Target Neighborhood Hits	831	Shared Neighborhood Hits	746
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MLKL_MOUSE
NC score	0.706343 (rank : 695)	θ value	0.00175202 (rank : 732)
Query Neighborhood Hits	1044	Target Neighborhood Hits	707	Shared Neighborhood Hits	651
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ACK1_MOUSE
NC score	0.705947 (rank : 696)	θ value	θ > 10 (rank : 1050)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1080	Shared Neighborhood Hits	761
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

EPHA8_MOUSE
NC score	0.705838 (rank : 697)	θ value	3.18553e-13 (rank : 326)
Query Neighborhood Hits	1044	Target Neighborhood Hits	969	Shared Neighborhood Hits	749
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA1_MOUSE
NC score	0.704746 (rank : 698)	θ value	4.91457e-14 (rank : 288)
Query Neighborhood Hits	1044	Target Neighborhood Hits	958	Shared Neighborhood Hits	735
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHB3_HUMAN
NC score	0.704490 (rank : 699)	θ value	1.47974e-10 (rank : 453)
Query Neighborhood Hits	1044	Target Neighborhood Hits	996	Shared Neighborhood Hits	757
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
NC score	0.703689 (rank : 700)	θ value	2.98157e-11 (rank : 424)
Query Neighborhood Hits	1044	Target Neighborhood Hits	996	Shared Neighborhood Hits	759
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

KC1E_HUMAN
NC score	0.703481 (rank : 701)	θ value	0.00390308 (rank : 747)
Query Neighborhood Hits	1044	Target Neighborhood Hits	732	Shared Neighborhood Hits	694
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
NC score	0.703474 (rank : 702)	θ value	0.00390308 (rank : 748)
Query Neighborhood Hits	1044	Target Neighborhood Hits	728	Shared Neighborhood Hits	694
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

ROR1_MOUSE
NC score	0.703039 (rank : 703)	θ value	3.41135e-07 (rank : 623)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1025	Shared Neighborhood Hits	756
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

FGFR2_MOUSE
NC score	0.702996 (rank : 704)	θ value	0.00102713 (rank : 723)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1062	Shared Neighborhood Hits	762
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

TITIN_HUMAN
NC score	0.702782 (rank : 705)	θ value	4.76016e-09 (rank : 535)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2923	Shared Neighborhood Hits	878
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ROR1_HUMAN
NC score	0.701693 (rank : 706)	θ value	2.61198e-07 (rank : 616)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1018	Shared Neighborhood Hits	753
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

RON_MOUSE
NC score	0.701188 (rank : 707)	θ value	8.40245e-06 (rank : 670)
Query Neighborhood Hits	1044	Target Neighborhood Hits	836	Shared Neighborhood Hits	746
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

FGFR2_HUMAN
NC score	0.700938 (rank : 708)	θ value	0.00102713 (rank : 722)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1062	Shared Neighborhood Hits	762
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

DDR2_HUMAN
NC score	0.700662 (rank : 709)	θ value	2.52405e-10 (rank : 466)
Query Neighborhood Hits	1044	Target Neighborhood Hits	818	Shared Neighborhood Hits	731
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ACVR1_MOUSE
NC score	0.698703 (rank : 710)	θ value	0.0252991 (rank : 781)
Query Neighborhood Hits	1044	Target Neighborhood Hits	768	Shared Neighborhood Hits	720
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

FGFR1_MOUSE
NC score	0.697442 (rank : 711)	θ value	0.00509761 (rank : 754)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1068	Shared Neighborhood Hits	765
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.697335 (rank : 712)	θ value	0.00509761 (rank : 753)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1069	Shared Neighborhood Hits	765
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

IRAK2_HUMAN
NC score	0.697111 (rank : 713)	θ value	2.36792 (rank : 935)
Query Neighborhood Hits	1044	Target Neighborhood Hits	714	Shared Neighborhood Hits	638
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

TIE2_HUMAN
NC score	0.695638 (rank : 714)	θ value	θ > 10 (rank : 1408)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1192	Shared Neighborhood Hits	758
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

NTRK1_HUMAN
NC score	0.694957 (rank : 715)	θ value	8.11959e-09 (rank : 542)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1023	Shared Neighborhood Hits	741
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

TIE2_MOUSE
NC score	0.694602 (rank : 716)	θ value	θ > 10 (rank : 1409)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1204	Shared Neighborhood Hits	758
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

ACVR1_HUMAN
NC score	0.694415 (rank : 717)	θ value	0.00298849 (rank : 739)
Query Neighborhood Hits	1044	Target Neighborhood Hits	760	Shared Neighborhood Hits	714
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

AVR2B_MOUSE
NC score	0.692054 (rank : 718)	θ value	1.06291 (rank : 893)
Query Neighborhood Hits	1044	Target Neighborhood Hits	749	Shared Neighborhood Hits	700
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.692010 (rank : 719)	θ value	1.06291 (rank : 892)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	700
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

ROS_HUMAN
NC score	0.691247 (rank : 720)	θ value	2.61198e-07 (rank : 617)
Query Neighborhood Hits	1044	Target Neighborhood Hits	907	Shared Neighborhood Hits	722
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

STYK1_HUMAN
NC score	0.690221 (rank : 721)	θ value	0.813845 (rank : 889)
Query Neighborhood Hits	1044	Target Neighborhood Hits	786	Shared Neighborhood Hits	723
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

IRAK3_HUMAN
NC score	0.690187 (rank : 722)	θ value	1.63604e-09 (rank : 509)
Query Neighborhood Hits	1044	Target Neighborhood Hits	644	Shared Neighborhood Hits	591
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

FGFR3_HUMAN
NC score	0.689462 (rank : 723)	θ value	0.0431538 (rank : 795)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1042	Shared Neighborhood Hits	762
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

KC1G1_MOUSE
NC score	0.688209 (rank : 724)	θ value	0.0148317 (rank : 773)
Query Neighborhood Hits	1044	Target Neighborhood Hits	713	Shared Neighborhood Hits	677
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

NTRK3_HUMAN
NC score	0.687232 (rank : 725)	θ value	1.09739e-05 (rank : 673)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1115	Shared Neighborhood Hits	745
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

KC1G1_HUMAN
NC score	0.686524 (rank : 726)	θ value	0.0148317 (rank : 772)
Query Neighborhood Hits	1044	Target Neighborhood Hits	708	Shared Neighborhood Hits	675
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

BMR1A_HUMAN
NC score	0.685964 (rank : 727)	θ value	0.0736092 (rank : 804)
Query Neighborhood Hits	1044	Target Neighborhood Hits	759	Shared Neighborhood Hits	706
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

IRAK3_MOUSE
NC score	0.685569 (rank : 728)	θ value	3.29651e-10 (rank : 472)
Query Neighborhood Hits	1044	Target Neighborhood Hits	628	Shared Neighborhood Hits	570
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KC1G3_HUMAN
NC score	0.685351 (rank : 729)	θ value	0.000786445 (rank : 717)
Query Neighborhood Hits	1044	Target Neighborhood Hits	711	Shared Neighborhood Hits	678
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

FGFR3_MOUSE
NC score	0.685299 (rank : 730)	θ value	0.0431538 (rank : 796)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1059	Shared Neighborhood Hits	760
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

BMR1A_MOUSE
NC score	0.684742 (rank : 731)	θ value	0.0736092 (rank : 805)
Query Neighborhood Hits	1044	Target Neighborhood Hits	758	Shared Neighborhood Hits	706
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

ROR2_HUMAN
NC score	0.681683 (rank : 732)	θ value	6.43352e-06 (rank : 666)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1014	Shared Neighborhood Hits	739
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

TIE1_MOUSE
NC score	0.680820 (rank : 733)	θ value	0.000158464 (rank : 696)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1266	Shared Neighborhood Hits	758
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

AATK_HUMAN
NC score	0.679701 (rank : 734)	θ value	θ > 10 (rank : 1047)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1243	Shared Neighborhood Hits	727
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

TIE1_HUMAN
NC score	0.678614 (rank : 735)	θ value	0.000158464 (rank : 695)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1241	Shared Neighborhood Hits	756
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TGFR1_HUMAN
NC score	0.678560 (rank : 736)	θ value	0.000461057 (rank : 710)
Query Neighborhood Hits	1044	Target Neighborhood Hits	755	Shared Neighborhood Hits	705
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.678348 (rank : 737)	θ value	0.000461057 (rank : 711)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	705
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

INSR_HUMAN
NC score	0.676915 (rank : 738)	θ value	θ > 10 (rank : 1219)
Query Neighborhood Hits	1044	Target Neighborhood Hits	963	Shared Neighborhood Hits	757
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

BMR1B_MOUSE
NC score	0.676682 (rank : 739)	θ value	0.00298849 (rank : 741)
Query Neighborhood Hits	1044	Target Neighborhood Hits	758	Shared Neighborhood Hits	706
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BMR1B_HUMAN
NC score	0.675968 (rank : 740)	θ value	0.00298849 (rank : 740)
Query Neighborhood Hits	1044	Target Neighborhood Hits	760	Shared Neighborhood Hits	706
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

FGFR4_HUMAN
NC score	0.675407 (rank : 741)	θ value	θ > 10 (rank : 1167)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1037	Shared Neighborhood Hits	754
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

ACV1B_MOUSE
NC score	0.675035 (rank : 742)	θ value	0.279714 (rank : 842)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	709
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.674850 (rank : 743)	θ value	0.279714 (rank : 841)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	709
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

EPHA6_MOUSE
NC score	0.674347 (rank : 744)	θ value	1.02475e-11 (rank : 407)
Query Neighborhood Hits	1044	Target Neighborhood Hits	946	Shared Neighborhood Hits	750
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

INSR_MOUSE
NC score	0.673971 (rank : 745)	θ value	θ > 10 (rank : 1220)
Query Neighborhood Hits	1044	Target Neighborhood Hits	968	Shared Neighborhood Hits	749
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

TOPK_MOUSE
NC score	0.673699 (rank : 746)	θ value	3.77169e-06 (rank : 656)
Query Neighborhood Hits	1044	Target Neighborhood Hits	618	Shared Neighborhood Hits	562
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

DDR1_HUMAN
NC score	0.673488 (rank : 747)	θ value	2.79066e-09 (rank : 525)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	724
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
NC score	0.673291 (rank : 748)	θ value	5.26297e-08 (rank : 583)
Query Neighborhood Hits	1044	Target Neighborhood Hits	818	Shared Neighborhood Hits	723
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

BMPR2_MOUSE
NC score	0.671608 (rank : 749)	θ value	5.44631e-05 (rank : 688)
Query Neighborhood Hits	1044	Target Neighborhood Hits	738	Shared Neighborhood Hits	664
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMPR2_HUMAN
NC score	0.670949 (rank : 750)	θ value	0.000270298 (rank : 703)
Query Neighborhood Hits	1044	Target Neighborhood Hits	736	Shared Neighborhood Hits	664
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

UFO_MOUSE
NC score	0.670267 (rank : 751)	θ value	0.00102713 (rank : 728)
Query Neighborhood Hits	1044	Target Neighborhood Hits	988	Shared Neighborhood Hits	714
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

STYK1_MOUSE
NC score	0.670201 (rank : 752)	θ value	θ > 10 (rank : 1391)
Query Neighborhood Hits	1044	Target Neighborhood Hits	779	Shared Neighborhood Hits	717
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TOPK_HUMAN
NC score	0.669443 (rank : 753)	θ value	1.53129e-07 (rank : 606)
Query Neighborhood Hits	1044	Target Neighborhood Hits	605	Shared Neighborhood Hits	551
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

ERBB3_MOUSE
NC score	0.669369 (rank : 754)	θ value	θ > 10 (rank : 1165)
Query Neighborhood Hits	1044	Target Neighborhood Hits	898	Shared Neighborhood Hits	727
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ANKK1_MOUSE
NC score	0.669143 (rank : 755)	θ value	1.058e-16 (rank : 173)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1072	Shared Neighborhood Hits	743
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

AATK_MOUSE
NC score	0.668977 (rank : 756)	θ value	θ > 10 (rank : 1048)
Query Neighborhood Hits	1044	Target Neighborhood Hits	942	Shared Neighborhood Hits	710
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

EPHA6_HUMAN
NC score	0.668448 (rank : 757)	θ value	1.74796e-11 (rank : 416)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	745
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

UFO_HUMAN
NC score	0.666202 (rank : 758)	θ value	0.00102713 (rank : 727)
Query Neighborhood Hits	1044	Target Neighborhood Hits	981	Shared Neighborhood Hits	713
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ERBB3_HUMAN
NC score	0.664666 (rank : 759)	θ value	θ > 10 (rank : 1164)
Query Neighborhood Hits	1044	Target Neighborhood Hits	918	Shared Neighborhood Hits	725
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

TYRO3_HUMAN
NC score	0.663826 (rank : 760)	θ value	0.163984 (rank : 832)
Query Neighborhood Hits	1044	Target Neighborhood Hits	995	Shared Neighborhood Hits	726
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

KC1G2_MOUSE
NC score	0.663456 (rank : 761)	θ value	0.000786445 (rank : 716)
Query Neighborhood Hits	1044	Target Neighborhood Hits	695	Shared Neighborhood Hits	663
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

TYRO3_MOUSE
NC score	0.662711 (rank : 762)	θ value	0.279714 (rank : 853)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1007	Shared Neighborhood Hits	725
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

KC1G2_HUMAN
NC score	0.661226 (rank : 763)	θ value	0.000786445 (rank : 715)
Query Neighborhood Hits	1044	Target Neighborhood Hits	693	Shared Neighborhood Hits	662
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

IGF1R_MOUSE
NC score	0.659538 (rank : 764)	θ value	0.0113563 (rank : 765)
Query Neighborhood Hits	1044	Target Neighborhood Hits	973	Shared Neighborhood Hits	741
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

RIPK4_HUMAN
NC score	0.658548 (rank : 765)	θ value	1.33837e-11 (rank : 413)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1094	Shared Neighborhood Hits	749
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

IGF1R_HUMAN
NC score	0.657076 (rank : 766)	θ value	0.0431538 (rank : 799)
Query Neighborhood Hits	1044	Target Neighborhood Hits	977	Shared Neighborhood Hits	740
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ANKK1_HUMAN
NC score	0.656687 (rank : 767)	θ value	6.85773e-16 (rank : 201)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1075	Shared Neighborhood Hits	739
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

MERTK_MOUSE
NC score	0.655163 (rank : 768)	θ value	θ > 10 (rank : 1251)
Query Neighborhood Hits	1044	Target Neighborhood Hits	974	Shared Neighborhood Hits	713
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

INSRR_MOUSE
NC score	0.655157 (rank : 769)	θ value	θ > 10 (rank : 1218)
Query Neighborhood Hits	1044	Target Neighborhood Hits	961	Shared Neighborhood Hits	731
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ROR2_MOUSE
NC score	0.655053 (rank : 770)	θ value	5.44631e-05 (rank : 690)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1000	Shared Neighborhood Hits	721
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

INSRR_HUMAN
NC score	0.653288 (rank : 771)	θ value	θ > 10 (rank : 1217)
Query Neighborhood Hits	1044	Target Neighborhood Hits	950	Shared Neighborhood Hits	730
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

PTK7_HUMAN
NC score	0.652572 (rank : 772)	θ value	2.79066e-09 (rank : 527)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1103	Shared Neighborhood Hits	734
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

ALK_HUMAN
NC score	0.652453 (rank : 773)	θ value	4.92598e-06 (rank : 658)
Query Neighborhood Hits	1044	Target Neighborhood Hits	795	Shared Neighborhood Hits	695
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ACVL1_MOUSE
NC score	0.652269 (rank : 774)	θ value	1.81305 (rank : 919)
Query Neighborhood Hits	1044	Target Neighborhood Hits	739	Shared Neighborhood Hits	697
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

FGFR4_MOUSE
NC score	0.651507 (rank : 775)	θ value	θ > 10 (rank : 1168)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1026	Shared Neighborhood Hits	743
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

ALK_MOUSE
NC score	0.650377 (rank : 776)	θ value	2.88788e-06 (rank : 651)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	700
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LTK_MOUSE
NC score	0.649245 (rank : 777)	θ value	0.00102713 (rank : 724)
Query Neighborhood Hits	1044	Target Neighborhood Hits	770	Shared Neighborhood Hits	696
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

MERTK_HUMAN
NC score	0.648902 (rank : 778)	θ value	θ > 10 (rank : 1250)
Query Neighborhood Hits	1044	Target Neighborhood Hits	988	Shared Neighborhood Hits	720
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

LTK_HUMAN
NC score	0.642967 (rank : 779)	θ value	0.00035302 (rank : 706)
Query Neighborhood Hits	1044	Target Neighborhood Hits	774	Shared Neighborhood Hits	703
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

MUSK_HUMAN
NC score	0.641947 (rank : 780)	θ value	1.99992e-07 (rank : 609)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1074	Shared Neighborhood Hits	736
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
NC score	0.638234 (rank : 781)	θ value	5.26297e-08 (rank : 589)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1057	Shared Neighborhood Hits	733
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

PGFRA_HUMAN
NC score	0.634019 (rank : 782)	θ value	θ > 10 (rank : 1303)
Query Neighborhood Hits	1044	Target Neighborhood Hits	980	Shared Neighborhood Hits	741
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

VGFR1_MOUSE
NC score	0.633690 (rank : 783)	θ value	0.00035302 (rank : 708)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1118	Shared Neighborhood Hits	753
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

PGFRA_MOUSE
NC score	0.632362 (rank : 784)	θ value	θ > 10 (rank : 1304)
Query Neighborhood Hits	1044	Target Neighborhood Hits	975	Shared Neighborhood Hits	739
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

KIT_HUMAN
NC score	0.630784 (rank : 785)	θ value	0.279714 (rank : 850)
Query Neighborhood Hits	1044	Target Neighborhood Hits	953	Shared Neighborhood Hits	745
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

ACVL1_HUMAN
NC score	0.628926 (rank : 786)	θ value	3.0926 (rank : 942)
Query Neighborhood Hits	1044	Target Neighborhood Hits	716	Shared Neighborhood Hits	672
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

VGFR3_MOUSE
NC score	0.628316 (rank : 787)	θ value	θ > 10 (rank : 1447)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1056	Shared Neighborhood Hits	739
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FLT3_HUMAN
NC score	0.628245 (rank : 788)	θ value	0.0193708 (rank : 778)
Query Neighborhood Hits	1044	Target Neighborhood Hits	843	Shared Neighborhood Hits	740
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

VGFR1_HUMAN
NC score	0.627662 (rank : 789)	θ value	4.1701e-05 (rank : 687)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1109	Shared Neighborhood Hits	750
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

PGFRB_HUMAN
NC score	0.626590 (rank : 790)	θ value	θ > 10 (rank : 1305)
Query Neighborhood Hits	1044	Target Neighborhood Hits	962	Shared Neighborhood Hits	739
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

VGFR3_HUMAN
NC score	0.626380 (rank : 791)	θ value	θ > 10 (rank : 1446)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1037	Shared Neighborhood Hits	741
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

PGFRB_MOUSE
NC score	0.625519 (rank : 792)	θ value	θ > 10 (rank : 1306)
Query Neighborhood Hits	1044	Target Neighborhood Hits	960	Shared Neighborhood Hits	741
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

FLT3_MOUSE
NC score	0.624371 (rank : 793)	θ value	0.0431538 (rank : 797)
Query Neighborhood Hits	1044	Target Neighborhood Hits	847	Shared Neighborhood Hits	738
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

KIT_MOUSE
NC score	0.624079 (rank : 794)	θ value	0.125558 (rank : 819)
Query Neighborhood Hits	1044	Target Neighborhood Hits	949	Shared Neighborhood Hits	744
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

VGFR2_MOUSE
NC score	0.622192 (rank : 795)	θ value	θ > 10 (rank : 1445)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1089	Shared Neighborhood Hits	742
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

ACV1C_MOUSE
NC score	0.621966 (rank : 796)	θ value	0.000602161 (rank : 713)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	659
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

MLKL_HUMAN
NC score	0.621516 (rank : 797)	θ value	3.19293e-05 (rank : 682)
Query Neighborhood Hits	1044	Target Neighborhood Hits	600	Shared Neighborhood Hits	541
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

SRPK1_MOUSE
NC score	0.620146 (rank : 798)	θ value	1.29631e-06 (rank : 644)
Query Neighborhood Hits	1044	Target Neighborhood Hits	639	Shared Neighborhood Hits	565
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

ACV1C_HUMAN
NC score	0.617149 (rank : 799)	θ value	0.000602161 (rank : 712)
Query Neighborhood Hits	1044	Target Neighborhood Hits	709	Shared Neighborhood Hits	653
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

VGFR2_HUMAN
NC score	0.616889 (rank : 800)	θ value	θ > 10 (rank : 1444)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1103	Shared Neighborhood Hits	744
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

SRPK1_HUMAN
NC score	0.616661 (rank : 801)	θ value	7.59969e-07 (rank : 638)
Query Neighborhood Hits	1044	Target Neighborhood Hits	706	Shared Neighborhood Hits	577
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

STK23_MOUSE
NC score	0.615910 (rank : 802)	θ value	5.26297e-08 (rank : 591)
Query Neighborhood Hits	1044	Target Neighborhood Hits	572	Shared Neighborhood Hits	555
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SCYL2_HUMAN
NC score	0.615108 (rank : 803)	θ value	θ > 10 (rank : 1357)
Query Neighborhood Hits	1044	Target Neighborhood Hits	632	Shared Neighborhood Hits	552
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

STK23_HUMAN
NC score	0.614797 (rank : 804)	θ value	5.26297e-08 (rank : 590)
Query Neighborhood Hits	1044	Target Neighborhood Hits	556	Shared Neighborhood Hits	550
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

SRPK2_MOUSE
NC score	0.614789 (rank : 805)	θ value	8.97725e-08 (rank : 598)
Query Neighborhood Hits	1044	Target Neighborhood Hits	765	Shared Neighborhood Hits	609
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_HUMAN
NC score	0.613615 (rank : 806)	θ value	8.97725e-08 (rank : 597)
Query Neighborhood Hits	1044	Target Neighborhood Hits	664	Shared Neighborhood Hits	576
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

EPHAA_HUMAN
NC score	0.610952 (rank : 807)	θ value	1.69304e-06 (rank : 646)
Query Neighborhood Hits	1044	Target Neighborhood Hits	960	Shared Neighborhood Hits	684
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

BUB1_MOUSE
NC score	0.601830 (rank : 808)	θ value	0.813845 (rank : 880)
Query Neighborhood Hits	1044	Target Neighborhood Hits	583	Shared Neighborhood Hits	537
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

EPHB6_MOUSE
NC score	0.598868 (rank : 809)	θ value	0.163984 (rank : 826)
Query Neighborhood Hits	1044	Target Neighborhood Hits	906	Shared Neighborhood Hits	657
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

CSF1R_HUMAN
NC score	0.596058 (rank : 810)	θ value	0.163984 (rank : 825)
Query Neighborhood Hits	1044	Target Neighborhood Hits	943	Shared Neighborhood Hits	740
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

SCYL2_MOUSE
NC score	0.593103 (rank : 811)	θ value	θ > 10 (rank : 1358)
Query Neighborhood Hits	1044	Target Neighborhood Hits	603	Shared Neighborhood Hits	524
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

CSF1R_MOUSE
NC score	0.589898 (rank : 812)	θ value	0.62314 (rank : 874)
Query Neighborhood Hits	1044	Target Neighborhood Hits	983	Shared Neighborhood Hits	741
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

RYK_MOUSE
NC score	0.588038 (rank : 813)	θ value	θ > 10 (rank : 1354)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	658
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

EPHB6_HUMAN
NC score	0.578705 (rank : 814)	θ value	0.279714 (rank : 844)
Query Neighborhood Hits	1044	Target Neighborhood Hits	912	Shared Neighborhood Hits	629
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

RYK_HUMAN
NC score	0.572379 (rank : 815)	θ value	θ > 10 (rank : 1353)
Query Neighborhood Hits	1044	Target Neighborhood Hits	701	Shared Neighborhood Hits	646
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

GUC2F_HUMAN
NC score	0.557797 (rank : 816)	θ value	θ > 10 (rank : 1193)
Query Neighborhood Hits	1044	Target Neighborhood Hits	740	Shared Neighborhood Hits	637
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

AMHR2_HUMAN
NC score	0.555678 (rank : 817)	θ value	θ > 10 (rank : 1055)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	621
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

NRBP_HUMAN
NC score	0.535833 (rank : 818)	θ value	1.43324e-05 (rank : 676)
Query Neighborhood Hits	1044	Target Neighborhood Hits	448	Shared Neighborhood Hits	402
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
NC score	0.534134 (rank : 819)	θ value	2.44474e-05 (rank : 681)
Query Neighborhood Hits	1044	Target Neighborhood Hits	442	Shared Neighborhood Hits	401
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

GUC2C_HUMAN
NC score	0.513814 (rank : 820)	θ value	0.00665767 (rank : 758)
Query Neighborhood Hits	1044	Target Neighborhood Hits	624	Shared Neighborhood Hits	541
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

VRK2_MOUSE
NC score	0.512611 (rank : 821)	θ value	0.0193708 (rank : 780)
Query Neighborhood Hits	1044	Target Neighborhood Hits	586	Shared Neighborhood Hits	559
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

TEX14_MOUSE
NC score	0.511310 (rank : 822)	θ value	θ > 10 (rank : 1405)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1333	Shared Neighborhood Hits	702
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ANPRB_HUMAN
NC score	0.506890 (rank : 823)	θ value	0.00509761 (rank : 751)
Query Neighborhood Hits	1044	Target Neighborhood Hits	646	Shared Neighborhood Hits	541
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GUC2D_HUMAN
NC score	0.504636 (rank : 824)	θ value	θ > 10 (rank : 1191)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	623
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

VRK2_HUMAN
NC score	0.493252 (rank : 825)	θ value	1.38821 (rank : 917)
Query Neighborhood Hits	1044	Target Neighborhood Hits	582	Shared Neighborhood Hits	544
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

GUC2G_MOUSE
NC score	0.487909 (rank : 826)	θ value	θ > 10 (rank : 1194)
Query Neighborhood Hits	1044	Target Neighborhood Hits	644	Shared Neighborhood Hits	541
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

GUC2E_MOUSE
NC score	0.486381 (rank : 827)	θ value	θ > 10 (rank : 1192)
Query Neighborhood Hits	1044	Target Neighborhood Hits	692	Shared Neighborhood Hits	600
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

VRK1_MOUSE
NC score	0.483064 (rank : 828)	θ value	θ > 10 (rank : 1449)
Query Neighborhood Hits	1044	Target Neighborhood Hits	583	Shared Neighborhood Hits	557
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK1_HUMAN
NC score	0.482616 (rank : 829)	θ value	θ > 10 (rank : 1448)
Query Neighborhood Hits	1044	Target Neighborhood Hits	584	Shared Neighborhood Hits	559
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

ANPRB_MOUSE
NC score	0.478533 (rank : 830)	θ value	0.0252991 (rank : 782)
Query Neighborhood Hits	1044	Target Neighborhood Hits	607	Shared Neighborhood Hits	516
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
NC score	0.475142 (rank : 831)	θ value	0.0563607 (rank : 800)
Query Neighborhood Hits	1044	Target Neighborhood Hits	600	Shared Neighborhood Hits	502
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.474718 (rank : 832)	θ value	0.00665767 (rank : 757)
Query Neighborhood Hits	1044	Target Neighborhood Hits	612	Shared Neighborhood Hits	504
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

TEX14_HUMAN
NC score	0.467018 (rank : 833)	θ value	θ > 10 (rank : 1404)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1103	Shared Neighborhood Hits	571
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ILK1_HUMAN
NC score	0.448000 (rank : 834)	θ value	θ > 10 (rank : 1213)
Query Neighborhood Hits	1044	Target Neighborhood Hits	857	Shared Neighborhood Hits	541
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.445824 (rank : 835)	θ value	θ > 10 (rank : 1215)
Query Neighborhood Hits	1044	Target Neighborhood Hits	858	Shared Neighborhood Hits	542
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK2_HUMAN
NC score	0.435336 (rank : 836)	θ value	θ > 10 (rank : 1214)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	535
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

BUB1_HUMAN
NC score	0.430790 (rank : 837)	θ value	0.0736092 (rank : 806)
Query Neighborhood Hits	1044	Target Neighborhood Hits	543	Shared Neighborhood Hits	412
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

PI3R4_MOUSE
NC score	0.374374 (rank : 838)	θ value	θ > 10 (rank : 1310)
Query Neighborhood Hits	1044	Target Neighborhood Hits	535	Shared Neighborhood Hits	343
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

STK31_HUMAN
NC score	0.365778 (rank : 839)	θ value	θ > 10 (rank : 1387)
Query Neighborhood Hits	1044	Target Neighborhood Hits	570	Shared Neighborhood Hits	431
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

PI3R4_HUMAN
NC score	0.361606 (rank : 840)	θ value	θ > 10 (rank : 1309)
Query Neighborhood Hits	1044	Target Neighborhood Hits	534	Shared Neighborhood Hits	345
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

NTKL_MOUSE
NC score	0.358719 (rank : 841)	θ value	θ > 10 (rank : 1287)
Query Neighborhood Hits	1044	Target Neighborhood Hits	326	Shared Neighborhood Hits	274
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

RN5A_MOUSE
NC score	0.338082 (rank : 842)	θ value	θ > 10 (rank : 1345)
Query Neighborhood Hits	1044	Target Neighborhood Hits	899	Shared Neighborhood Hits	584
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

K2002_HUMAN
NC score	0.327049 (rank : 843)	θ value	2.36792 (rank : 936)
Query Neighborhood Hits	1044	Target Neighborhood Hits	274	Shared Neighborhood Hits	255
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

STK31_MOUSE
NC score	0.308333 (rank : 844)	θ value	θ > 10 (rank : 1388)
Query Neighborhood Hits	1044	Target Neighborhood Hits	474	Shared Neighborhood Hits	366
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

NTKL_HUMAN
NC score	0.274778 (rank : 845)	θ value	θ > 10 (rank : 1286)
Query Neighborhood Hits	1044	Target Neighborhood Hits	266	Shared Neighborhood Hits	209
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

K2002_MOUSE
NC score	0.268217 (rank : 846)	θ value	θ > 10 (rank : 1225)
Query Neighborhood Hits	1044	Target Neighborhood Hits	267	Shared Neighborhood Hits	226
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

VRK3_HUMAN
NC score	0.263314 (rank : 847)	θ value	θ > 10 (rank : 1450)
Query Neighborhood Hits	1044	Target Neighborhood Hits	349	Shared Neighborhood Hits	299
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VRK3_MOUSE
NC score	0.245338 (rank : 848)	θ value	θ > 10 (rank : 1451)
Query Neighborhood Hits	1044	Target Neighborhood Hits	342	Shared Neighborhood Hits	304
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

PXK_MOUSE
NC score	0.184124 (rank : 849)	θ value	θ > 10 (rank : 1325)
Query Neighborhood Hits	1044	Target Neighborhood Hits	320	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RN5A_HUMAN
NC score	0.159409 (rank : 850)	θ value	θ > 10 (rank : 1344)
Query Neighborhood Hits	1044	Target Neighborhood Hits	608	Shared Neighborhood Hits	322
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

PRPK_MOUSE
NC score	0.154354 (rank : 851)	θ value	θ > 10 (rank : 1323)
Query Neighborhood Hits	1044	Target Neighborhood Hits	139	Shared Neighborhood Hits	127
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_HUMAN
NC score	0.146034 (rank : 852)	θ value	θ > 10 (rank : 1322)
Query Neighborhood Hits	1044	Target Neighborhood Hits	131	Shared Neighborhood Hits	122
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PXK_HUMAN
NC score	0.137338 (rank : 853)	θ value	θ > 10 (rank : 1324)
Query Neighborhood Hits	1044	Target Neighborhood Hits	216	Shared Neighborhood Hits	129
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SLAP2_MOUSE
NC score	0.133375 (rank : 854)	θ value	θ > 10 (rank : 1370)
Query Neighborhood Hits	1044	Target Neighborhood Hits	136	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.128592 (rank : 855)	θ value	θ > 10 (rank : 1369)
Query Neighborhood Hits	1044	Target Neighborhood Hits	139	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP1_HUMAN
NC score	0.127212 (rank : 856)	θ value	θ > 10 (rank : 1367)
Query Neighborhood Hits	1044	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.125656 (rank : 857)	θ value	θ > 10 (rank : 1368)
Query Neighborhood Hits	1044	Target Neighborhood Hits	117	Shared Neighborhood Hits	41
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

BUB1B_HUMAN
NC score	0.105942 (rank : 858)	θ value	θ > 10 (rank : 1071)
Query Neighborhood Hits	1044	Target Neighborhood Hits	208	Shared Neighborhood Hits	144
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

CCD19_HUMAN
NC score	0.098187 (rank : 859)	θ value	0.0961366 (rank : 812)
Query Neighborhood Hits	1044	Target Neighborhood Hits	639	Shared Neighborhood Hits	180
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

GRAP_HUMAN
NC score	0.095851 (rank : 860)	θ value	θ > 10 (rank : 1184)
Query Neighborhood Hits	1044	Target Neighborhood Hits	307	Shared Neighborhood Hits	54
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

STAC3_MOUSE
NC score	0.095755 (rank : 861)	θ value	θ > 10 (rank : 1382)
Query Neighborhood Hits	1044	Target Neighborhood Hits	232	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

MY18A_MOUSE
NC score	0.095691 (rank : 862)	θ value	0.000158464 (rank : 694)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1989	Shared Neighborhood Hits	294
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

GRAP_MOUSE
NC score	0.095430 (rank : 863)	θ value	θ > 10 (rank : 1185)
Query Neighborhood Hits	1044	Target Neighborhood Hits	309	Shared Neighborhood Hits	53
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

STAC3_HUMAN
NC score	0.095080 (rank : 864)	θ value	θ > 10 (rank : 1381)
Query Neighborhood Hits	1044	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_MOUSE
NC score	0.094969 (rank : 865)	θ value	θ > 10 (rank : 1384)
Query Neighborhood Hits	1044	Target Neighborhood Hits	268	Shared Neighborhood Hits	75
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MY18A_HUMAN
NC score	0.094881 (rank : 866)	θ value	0.0193708 (rank : 779)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1929	Shared Neighborhood Hits	283
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

GRAP2_HUMAN
NC score	0.093563 (rank : 867)	θ value	θ > 10 (rank : 1182)
Query Neighborhood Hits	1044	Target Neighborhood Hits	304	Shared Neighborhood Hits	53
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

CING_MOUSE
NC score	0.093408 (rank : 868)	θ value	0.0252991 (rank : 783)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1432	Shared Neighborhood Hits	250
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CING_HUMAN
NC score	0.093407 (rank : 869)	θ value	0.0193708 (rank : 777)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1275	Shared Neighborhood Hits	244
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

GRB2_HUMAN
NC score	0.093223 (rank : 870)	θ value	θ > 10 (rank : 1188)
Query Neighborhood Hits	1044	Target Neighborhood Hits	310	Shared Neighborhood Hits	55
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.093177 (rank : 871)	θ value	θ > 10 (rank : 1189)
Query Neighborhood Hits	1044	Target Neighborhood Hits	312	Shared Neighborhood Hits	55
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
NC score	0.092750 (rank : 872)	θ value	θ > 10 (rank : 1190)
Query Neighborhood Hits	1044	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

TRHY_HUMAN
NC score	0.092287 (rank : 873)	θ value	0.00228821 (rank : 738)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1385	Shared Neighborhood Hits	223
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

GRAP2_MOUSE
NC score	0.092240 (rank : 874)	θ value	θ > 10 (rank : 1183)
Query Neighborhood Hits	1044	Target Neighborhood Hits	297	Shared Neighborhood Hits	52
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CCD11_HUMAN
NC score	0.091556 (rank : 875)	θ value	θ > 10 (rank : 1080)
Query Neighborhood Hits	1044	Target Neighborhood Hits	822	Shared Neighborhood Hits	220
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

XE7_HUMAN
NC score	0.091550 (rank : 876)	θ value	0.0113563 (rank : 769)
Query Neighborhood Hits	1044	Target Neighborhood Hits	738	Shared Neighborhood Hits	176
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

PIBF1_HUMAN
NC score	0.090747 (rank : 877)	θ value	θ > 10 (rank : 1311)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1041	Shared Neighborhood Hits	232
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

NCK1_HUMAN
NC score	0.090698 (rank : 878)	θ value	θ > 10 (rank : 1276)
Query Neighborhood Hits	1044	Target Neighborhood Hits	312	Shared Neighborhood Hits	55
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

INCE_MOUSE
NC score	0.090302 (rank : 879)	θ value	0.62314 (rank : 875)
Query Neighborhood Hits	1044	Target Neighborhood Hits	903	Shared Neighborhood Hits	194
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

NCK2_HUMAN
NC score	0.090113 (rank : 880)	θ value	θ > 10 (rank : 1277)
Query Neighborhood Hits	1044	Target Neighborhood Hits	310	Shared Neighborhood Hits	53
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

MYH1_MOUSE
NC score	0.089733 (rank : 881)	θ value	5.44631e-05 (rank : 689)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1461	Shared Neighborhood Hits	249
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH1_HUMAN
NC score	0.089290 (rank : 882)	θ value	0.000121331 (rank : 693)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1478	Shared Neighborhood Hits	244
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH2_HUMAN
NC score	0.089066 (rank : 883)	θ value	4.1701e-05 (rank : 685)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1491	Shared Neighborhood Hits	243
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

SH21B_MOUSE
NC score	0.088798 (rank : 884)	θ value	θ > 10 (rank : 1363)
Query Neighborhood Hits	1044	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

MYH8_HUMAN
NC score	0.088483 (rank : 885)	θ value	0.00102713 (rank : 725)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1610	Shared Neighborhood Hits	255
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

K0555_HUMAN
NC score	0.088126 (rank : 886)	θ value	θ > 10 (rank : 1223)
Query Neighborhood Hits	1044	Target Neighborhood Hits	880	Shared Neighborhood Hits	218
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

STAC_HUMAN
NC score	0.088035 (rank : 887)	θ value	θ > 10 (rank : 1383)
Query Neighborhood Hits	1044	Target Neighborhood Hits	276	Shared Neighborhood Hits	75
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MYH7_HUMAN
NC score	0.087823 (rank : 888)	θ value	0.00390308 (rank : 749)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1559	Shared Neighborhood Hits	252
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

CCD46_HUMAN
NC score	0.087621 (rank : 889)	θ value	θ > 10 (rank : 1091)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1430	Shared Neighborhood Hits	257
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

MYH6_MOUSE
NC score	0.087585 (rank : 890)	θ value	0.0148317 (rank : 774)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1501	Shared Neighborhood Hits	252
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

GRAP1_MOUSE
NC score	0.087414 (rank : 891)	θ value	0.163984 (rank : 828)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1234	Shared Neighborhood Hits	241
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

MYH14_MOUSE
NC score	0.087291 (rank : 892)	θ value	0.00298849 (rank : 746)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1225	Shared Neighborhood Hits	227
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH4_MOUSE
NC score	0.087274 (rank : 893)	θ value	0.00035302 (rank : 707)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1476	Shared Neighborhood Hits	244
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH8_MOUSE
NC score	0.087010 (rank : 894)	θ value	0.00102713 (rank : 726)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1600	Shared Neighborhood Hits	252
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH4_HUMAN
NC score	0.086926 (rank : 895)	θ value	0.000786445 (rank : 718)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1377	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

INVO_HUMAN
NC score	0.086804 (rank : 896)	θ value	2.36792 (rank : 934)
Query Neighborhood Hits	1044	Target Neighborhood Hits	636	Shared Neighborhood Hits	170
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

MYH11_HUMAN
NC score	0.086684 (rank : 897)	θ value	0.000270298 (rank : 705)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1806	Shared Neighborhood Hits	260
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CROCC_MOUSE
NC score	0.086544 (rank : 898)	θ value	0.00102713 (rank : 721)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1460	Shared Neighborhood Hits	244
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CF060_HUMAN
NC score	0.086538 (rank : 899)	θ value	0.279714 (rank : 843)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1270	Shared Neighborhood Hits	247
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

INCE_HUMAN
NC score	0.086380 (rank : 900)	θ value	5.27518 (rank : 983)
Query Neighborhood Hits	1044	Target Neighborhood Hits	978	Shared Neighborhood Hits	197
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

BUB1B_MOUSE
NC score	0.086250 (rank : 901)	θ value	θ > 10 (rank : 1072)
Query Neighborhood Hits	1044	Target Neighborhood Hits	202	Shared Neighborhood Hits	119
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

MYH6_HUMAN
NC score	0.086106 (rank : 902)	θ value	0.0252991 (rank : 786)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1426	Shared Neighborhood Hits	244
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH11_MOUSE
NC score	0.085955 (rank : 903)	θ value	0.00298849 (rank : 745)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1777	Shared Neighborhood Hits	255
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH13_HUMAN
NC score	0.085860 (rank : 904)	θ value	0.0961366 (rank : 817)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1504	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

CCD46_MOUSE
NC score	0.085700 (rank : 905)	θ value	8.99809 (rank : 1021)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1405	Shared Neighborhood Hits	245
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

RB6I2_HUMAN
NC score	0.085629 (rank : 906)	θ value	0.21417 (rank : 837)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1584	Shared Neighborhood Hits	262
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

ITSN1_HUMAN
NC score	0.085612 (rank : 907)	θ value	0.0148317 (rank : 771)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1757	Shared Neighborhood Hits	294
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SWP70_MOUSE
NC score	0.085414 (rank : 908)	θ value	0.0736092 (rank : 809)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1097	Shared Neighborhood Hits	235
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GOGA5_HUMAN
NC score	0.085293 (rank : 909)	θ value	0.0113563 (rank : 764)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1168	Shared Neighborhood Hits	232
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

RB6I2_MOUSE
NC score	0.085253 (rank : 910)	θ value	0.0252991 (rank : 788)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1433	Shared Neighborhood Hits	249
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

GRAP1_HUMAN
NC score	0.085132 (rank : 911)	θ value	0.0431538 (rank : 798)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	214
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

MYH3_HUMAN
NC score	0.084689 (rank : 912)	θ value	θ > 10 (rank : 1258)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1660	Shared Neighborhood Hits	247
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH9_HUMAN
NC score	0.084503 (rank : 913)	θ value	0.00869519 (rank : 761)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1762	Shared Neighborhood Hits	260
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

CALD1_HUMAN
NC score	0.084311 (rank : 914)	θ value	0.0431538 (rank : 793)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	195
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CROCC_HUMAN
NC score	0.084295 (rank : 915)	θ value	0.00228821 (rank : 735)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1409	Shared Neighborhood Hits	248
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

VAV3_HUMAN
NC score	0.084229 (rank : 916)	θ value	θ > 10 (rank : 1439)
Query Neighborhood Hits	1044	Target Neighborhood Hits	398	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ITSN1_MOUSE
NC score	0.083564 (rank : 917)	θ value	θ > 10 (rank : 1222)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1669	Shared Neighborhood Hits	287
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RAD50_HUMAN
NC score	0.083486 (rank : 918)	θ value	0.279714 (rank : 852)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1317	Shared Neighborhood Hits	236
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

VAV3_MOUSE
NC score	0.083482 (rank : 919)	θ value	θ > 10 (rank : 1440)
Query Neighborhood Hits	1044	Target Neighborhood Hits	404	Shared Neighborhood Hits	88
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ITSN2_MOUSE
NC score	0.083434 (rank : 920)	θ value	0.0961366 (rank : 816)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1371	Shared Neighborhood Hits	270
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MYH9_MOUSE
NC score	0.083197 (rank : 921)	θ value	0.21417 (rank : 835)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1829	Shared Neighborhood Hits	263
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH10_MOUSE
NC score	0.083194 (rank : 922)	θ value	0.00298849 (rank : 744)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1612	Shared Neighborhood Hits	250
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_HUMAN
NC score	0.083177 (rank : 923)	θ value	0.0113563 (rank : 766)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1620	Shared Neighborhood Hits	250
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

CP250_MOUSE
NC score	0.082863 (rank : 924)	θ value	0.00134147 (rank : 729)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1583	Shared Neighborhood Hits	247
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

SDCG8_HUMAN
NC score	0.082823 (rank : 925)	θ value	θ > 10 (rank : 1359)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1002	Shared Neighborhood Hits	242
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

CI093_HUMAN
NC score	0.082642 (rank : 926)	θ value	θ > 10 (rank : 1121)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1088	Shared Neighborhood Hits	220
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

GOGA5_MOUSE
NC score	0.082551 (rank : 927)	θ value	0.0252991 (rank : 785)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1434	Shared Neighborhood Hits	247
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

SH24A_HUMAN
NC score	0.082276 (rank : 928)	θ value	θ > 10 (rank : 1364)
Query Neighborhood Hits	1044	Target Neighborhood Hits	455	Shared Neighborhood Hits	160
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

CP135_MOUSE
NC score	0.082221 (rank : 929)	θ value	1.38821 (rank : 907)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1278	Shared Neighborhood Hits	241
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

GOGA4_MOUSE
NC score	0.082167 (rank : 930)	θ value	0.0252991 (rank : 784)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1939	Shared Neighborhood Hits	280
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

CE290_HUMAN
NC score	0.082162 (rank : 931)	θ value	0.0961366 (rank : 813)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1553	Shared Neighborhood Hits	245
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CCD41_HUMAN
NC score	0.082146 (rank : 932)	θ value	2.36792 (rank : 932)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1139	Shared Neighborhood Hits	233
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

GOGA1_MOUSE
NC score	0.082076 (rank : 933)	θ value	θ > 10 (rank : 1178)
Query Neighborhood Hits	1044	Target Neighborhood Hits	994	Shared Neighborhood Hits	225
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

MYH14_HUMAN
NC score	0.082006 (rank : 934)	θ value	0.365318 (rank : 858)
Query Neighborhood Hits	1044	Target Neighborhood Hits	995	Shared Neighborhood Hits	187
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

CN145_HUMAN
NC score	0.081876 (rank : 935)	θ value	8.99809 (rank : 1023)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1196	Shared Neighborhood Hits	239
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CI039_HUMAN
NC score	0.081862 (rank : 936)	θ value	θ > 10 (rank : 1120)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1171	Shared Neighborhood Hits	231
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

GAS8_HUMAN
NC score	0.081850 (rank : 937)	θ value	θ > 10 (rank : 1170)
Query Neighborhood Hits	1044	Target Neighborhood Hits	819	Shared Neighborhood Hits	216
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

CCD11_MOUSE
NC score	0.081803 (rank : 938)	θ value	θ > 10 (rank : 1081)
Query Neighborhood Hits	1044	Target Neighborhood Hits	498	Shared Neighborhood Hits	152
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

NIN_HUMAN
NC score	0.081799 (rank : 939)	θ value	3.0926 (rank : 952)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1416	Shared Neighborhood Hits	251
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

PCNT_HUMAN
NC score	0.081781 (rank : 940)	θ value	1.38821 (rank : 915)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1551	Shared Neighborhood Hits	253
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

CCD41_MOUSE
NC score	0.081777 (rank : 941)	θ value	θ > 10 (rank : 1087)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1399	Shared Neighborhood Hits	246
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

GOGA1_HUMAN
NC score	0.081718 (rank : 942)	θ value	0.365318 (rank : 855)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1222	Shared Neighborhood Hits	234
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

ITSN2_HUMAN
NC score	0.081653 (rank : 943)	θ value	0.0961366 (rank : 815)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1173	Shared Neighborhood Hits	232
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CE152_HUMAN
NC score	0.081644 (rank : 944)	θ value	θ > 10 (rank : 1102)
Query Neighborhood Hits	1044	Target Neighborhood Hits	976	Shared Neighborhood Hits	206
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

SH21A_MOUSE
NC score	0.081558 (rank : 945)	θ value	θ > 10 (rank : 1361)
Query Neighborhood Hits	1044	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

CT2NL_HUMAN
NC score	0.081505 (rank : 946)	θ value	0.0736092 (rank : 807)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1059	Shared Neighborhood Hits	223
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

AKAP9_HUMAN
NC score	0.081499 (rank : 947)	θ value	0.0113563 (rank : 763)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1710	Shared Neighborhood Hits	265
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

NIN_MOUSE
NC score	0.081433 (rank : 948)	θ value	0.0736092 (rank : 808)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1376	Shared Neighborhood Hits	236
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

VAV_HUMAN
NC score	0.081402 (rank : 949)	θ value	θ > 10 (rank : 1441)
Query Neighborhood Hits	1044	Target Neighborhood Hits	452	Shared Neighborhood Hits	91
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

GOGA4_HUMAN
NC score	0.081349 (rank : 950)	θ value	1.06291 (rank : 897)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2034	Shared Neighborhood Hits	278
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

MYO5A_HUMAN
NC score	0.081341 (rank : 951)	θ value	0.47712 (rank : 867)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1092	Shared Neighborhood Hits	230
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MD1L1_MOUSE
NC score	0.081245 (rank : 952)	θ value	θ > 10 (rank : 1249)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1001	Shared Neighborhood Hits	219
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

PCNT_MOUSE
NC score	0.081243 (rank : 953)	θ value	0.47712 (rank : 868)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1207	Shared Neighborhood Hits	230
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

IFT81_MOUSE
NC score	0.081095 (rank : 954)	θ value	θ > 10 (rank : 1212)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	223
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

REST_HUMAN
NC score	0.081052 (rank : 955)	θ value	0.00134147 (rank : 730)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1605	Shared Neighborhood Hits	258
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

GOGB1_HUMAN
NC score	0.080952 (rank : 956)	θ value	0.279714 (rank : 846)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2297	Shared Neighborhood Hits	298
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

VAV2_HUMAN
NC score	0.080934 (rank : 957)	θ value	θ > 10 (rank : 1437)
Query Neighborhood Hits	1044	Target Neighborhood Hits	453	Shared Neighborhood Hits	94
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

CT2NL_MOUSE
NC score	0.080832 (rank : 958)	θ value	0.365318 (rank : 854)
Query Neighborhood Hits	1044	Target Neighborhood Hits	902	Shared Neighborhood Hits	214
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CP250_HUMAN
NC score	0.080830 (rank : 959)	θ value	θ > 10 (rank : 1130)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1805	Shared Neighborhood Hits	264
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CCD21_MOUSE
NC score	0.080725 (rank : 960)	θ value	θ > 10 (rank : 1084)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1135	Shared Neighborhood Hits	246
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CEP63_HUMAN
NC score	0.080516 (rank : 961)	θ value	θ > 10 (rank : 1108)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1005	Shared Neighborhood Hits	221
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

RAD50_MOUSE
NC score	0.080482 (rank : 962)	θ value	5.27518 (rank : 986)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1366	Shared Neighborhood Hits	236
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

GOGA6_HUMAN
NC score	0.080391 (rank : 963)	θ value	0.365318 (rank : 856)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1007	Shared Neighborhood Hits	220
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

P85B_MOUSE
NC score	0.080373 (rank : 964)	θ value	θ > 10 (rank : 1298)
Query Neighborhood Hits	1044	Target Neighborhood Hits	519	Shared Neighborhood Hits	182
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

BRE1B_HUMAN
NC score	0.080279 (rank : 965)	θ value	0.163984 (rank : 824)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1040	Shared Neighborhood Hits	213
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

SWP70_HUMAN
NC score	0.080219 (rank : 966)	θ value	5.27518 (rank : 990)
Query Neighborhood Hits	1044	Target Neighborhood Hits	973	Shared Neighborhood Hits	219
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ERC2_MOUSE
NC score	0.079886 (rank : 967)	θ value	0.163984 (rank : 827)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1166	Shared Neighborhood Hits	224
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

MYO5C_HUMAN
NC score	0.079710 (rank : 968)	θ value	θ > 10 (rank : 1264)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1206	Shared Neighborhood Hits	236
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

SMC1A_MOUSE
NC score	0.079697 (rank : 969)	θ value	5.27518 (rank : 989)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1384	Shared Neighborhood Hits	249
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

CA065_HUMAN
NC score	0.079644 (rank : 970)	θ value	θ > 10 (rank : 1073)
Query Neighborhood Hits	1044	Target Neighborhood Hits	469	Shared Neighborhood Hits	155
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

MD1L1_HUMAN
NC score	0.079638 (rank : 971)	θ value	θ > 10 (rank : 1248)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	211
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

TRIPB_HUMAN
NC score	0.079615 (rank : 972)	θ value	0.163984 (rank : 831)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1587	Shared Neighborhood Hits	260
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

TPR_HUMAN
NC score	0.079495 (rank : 973)	θ value	1.06291 (rank : 904)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1921	Shared Neighborhood Hits	275
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

GAS8_MOUSE
NC score	0.079493 (rank : 974)	θ value	θ > 10 (rank : 1171)
Query Neighborhood Hits	1044	Target Neighborhood Hits	622	Shared Neighborhood Hits	192
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

RASA1_HUMAN
NC score	0.079469 (rank : 975)	θ value	θ > 10 (rank : 1331)
Query Neighborhood Hits	1044	Target Neighborhood Hits	258	Shared Neighborhood Hits	70
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

MY18B_HUMAN
NC score	0.079466 (rank : 976)	θ value	θ > 10 (rank : 1257)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1299	Shared Neighborhood Hits	232
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

CENPF_HUMAN
NC score	0.079465 (rank : 977)	θ value	1.38821 (rank : 905)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1932	Shared Neighborhood Hits	268
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

AZI1_HUMAN
NC score	0.079390 (rank : 978)	θ value	θ > 10 (rank : 1065)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1000	Shared Neighborhood Hits	221
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CCD39_MOUSE
NC score	0.079298 (rank : 979)	θ value	θ > 10 (rank : 1086)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1026	Shared Neighborhood Hits	220
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

SH21B_HUMAN
NC score	0.079261 (rank : 980)	θ value	θ > 10 (rank : 1362)
Query Neighborhood Hits	1044	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

GOGA3_MOUSE
NC score	0.079194 (rank : 981)	θ value	1.38821 (rank : 911)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1437	Shared Neighborhood Hits	238
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

IFT81_HUMAN
NC score	0.079191 (rank : 982)	θ value	θ > 10 (rank : 1211)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	214
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CP135_HUMAN
NC score	0.079190 (rank : 983)	θ value	5.27518 (rank : 977)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1290	Shared Neighborhood Hits	232
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CARD9_HUMAN
NC score	0.079093 (rank : 984)	θ value	8.99809 (rank : 1020)
Query Neighborhood Hits	1044	Target Neighborhood Hits	602	Shared Neighborhood Hits	196
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

DGKD_HUMAN
NC score	0.079087 (rank : 985)	θ value	θ > 10 (rank : 1154)
Query Neighborhood Hits	1044	Target Neighborhood Hits	231	Shared Neighborhood Hits	82
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

KTN1_MOUSE
NC score	0.078809 (rank : 986)	θ value	1.06291 (rank : 900)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1324	Shared Neighborhood Hits	240
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

SYCP1_MOUSE
NC score	0.078785 (rank : 987)	θ value	0.00228821 (rank : 737)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1456	Shared Neighborhood Hits	244
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SMC3_MOUSE
NC score	0.078782 (rank : 988)	θ value	0.0563607 (rank : 803)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1187	Shared Neighborhood Hits	232
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

DESP_HUMAN
NC score	0.078777 (rank : 989)	θ value	θ > 10 (rank : 1152)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1470	Shared Neighborhood Hits	260
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

NAF1_MOUSE
NC score	0.078749 (rank : 990)	θ value	1.81305 (rank : 926)
Query Neighborhood Hits	1044	Target Neighborhood Hits	852	Shared Neighborhood Hits	217
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

CYLN2_HUMAN
NC score	0.078704 (rank : 991)	θ value	θ > 10 (rank : 1144)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1004	Shared Neighborhood Hits	233
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

SMC3_HUMAN
NC score	0.078630 (rank : 992)	θ value	0.0563607 (rank : 802)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1186	Shared Neighborhood Hits	232
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

BPAEA_MOUSE
NC score	0.078602 (rank : 993)	θ value	0.00228821 (rank : 734)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1480	Shared Neighborhood Hits	254
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CCD91_HUMAN
NC score	0.078550 (rank : 994)	θ value	0.813845 (rank : 882)
Query Neighborhood Hits	1044	Target Neighborhood Hits	868	Shared Neighborhood Hits	221
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

LRC45_MOUSE
NC score	0.078498 (rank : 995)	θ value	6.88961 (rank : 999)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	216
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

P85B_HUMAN
NC score	0.078460 (rank : 996)	θ value	θ > 10 (rank : 1297)
Query Neighborhood Hits	1044	Target Neighborhood Hits	543	Shared Neighborhood Hits	182
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

MYO5A_MOUSE
NC score	0.078315 (rank : 997)	θ value	1.38821 (rank : 914)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1117	Shared Neighborhood Hits	226
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

BRE1B_MOUSE
NC score	0.078230 (rank : 998)	θ value	0.47712 (rank : 861)
Query Neighborhood Hits	1044	Target Neighborhood Hits	970	Shared Neighborhood Hits	206
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

RIMB1_MOUSE
NC score	0.077672 (rank : 999)	θ value	θ > 10 (rank : 1343)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1376	Shared Neighborhood Hits	260
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CCD91_MOUSE
NC score	0.077412 (rank : 1000)	θ value	2.36792 (rank : 933)
Query Neighborhood Hits	1044	Target Neighborhood Hits	699	Shared Neighborhood Hits	198
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

CJ118_MOUSE
NC score	0.077412 (rank : 1001)	θ value	0.62314 (rank : 873)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1132	Shared Neighborhood Hits	228
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

VAV2_MOUSE
NC score	0.077400 (rank : 1002)	θ value	θ > 10 (rank : 1438)
Query Neighborhood Hits	1044	Target Neighborhood Hits	456	Shared Neighborhood Hits	92
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

SDCG8_MOUSE
NC score	0.077233 (rank : 1003)	θ value	6.88961 (rank : 1005)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	218
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

ERC2_HUMAN
NC score	0.077226 (rank : 1004)	θ value	0.0563607 (rank : 801)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1156	Shared Neighborhood Hits	220
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

P55G_HUMAN
NC score	0.077207 (rank : 1005)	θ value	θ > 10 (rank : 1293)
Query Neighborhood Hits	1044	Target Neighborhood Hits	451	Shared Neighborhood Hits	171
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

HMMR_MOUSE
NC score	0.077117 (rank : 1006)	θ value	5.27518 (rank : 981)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1178	Shared Neighborhood Hits	229
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

CCD62_HUMAN
NC score	0.077098 (rank : 1007)	θ value	θ > 10 (rank : 1092)
Query Neighborhood Hits	1044	Target Neighborhood Hits	631	Shared Neighborhood Hits	188
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

CYLN2_MOUSE
NC score	0.077022 (rank : 1008)	θ value	θ > 10 (rank : 1145)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1002	Shared Neighborhood Hits	231
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

CNTRB_MOUSE
NC score	0.077004 (rank : 1009)	θ value	θ > 10 (rank : 1129)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1029	Shared Neighborhood Hits	226
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

PEPL_HUMAN
NC score	0.076906 (rank : 1010)	θ value	0.62314 (rank : 876)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1141	Shared Neighborhood Hits	233
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

RBM25_HUMAN
NC score	0.076740 (rank : 1011)	θ value	θ > 10 (rank : 1337)
Query Neighborhood Hits	1044	Target Neighborhood Hits	682	Shared Neighborhood Hits	155
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

FLIP1_HUMAN
NC score	0.076588 (rank : 1012)	θ value	3.0926 (rank : 945)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1405	Shared Neighborhood Hits	249
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

REST_MOUSE
NC score	0.076509 (rank : 1013)	θ value	0.62314 (rank : 878)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1506	Shared Neighborhood Hits	242
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RBP24_HUMAN
NC score	0.076475 (rank : 1014)	θ value	θ > 10 (rank : 1338)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1559	Shared Neighborhood Hits	251
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

RABE1_MOUSE
NC score	0.076408 (rank : 1015)	θ value	θ > 10 (rank : 1327)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1105	Shared Neighborhood Hits	225
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

UACA_MOUSE
NC score	0.076395 (rank : 1016)	θ value	0.163984 (rank : 833)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1620	Shared Neighborhood Hits	249
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

GCC2_HUMAN
NC score	0.076263 (rank : 1017)	θ value	θ > 10 (rank : 1174)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1558	Shared Neighborhood Hits	250
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

TSC1_HUMAN
NC score	0.076149 (rank : 1018)	θ value	θ > 10 (rank : 1424)
Query Neighborhood Hits	1044	Target Neighborhood Hits	765	Shared Neighborhood Hits	197
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

PHLB2_MOUSE
NC score	0.076070 (rank : 1019)	θ value	2.36792 (rank : 939)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1016	Shared Neighborhood Hits	231
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

CCD45_MOUSE
NC score	0.075853 (rank : 1020)	θ value	θ > 10 (rank : 1090)
Query Neighborhood Hits	1044	Target Neighborhood Hits	663	Shared Neighborhood Hits	191
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

SH21A_HUMAN
NC score	0.075802 (rank : 1021)	θ value	θ > 10 (rank : 1360)
Query Neighborhood Hits	1044	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SMC1A_HUMAN
NC score	0.075764 (rank : 1022)	θ value	3.0926 (rank : 956)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1346	Shared Neighborhood Hits	242
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

HMMR_HUMAN
NC score	0.075752 (rank : 1023)	θ value	1.81305 (rank : 922)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1082	Shared Neighborhood Hits	211
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

CCHCR_MOUSE
NC score	0.075750 (rank : 1024)	θ value	θ > 10 (rank : 1099)
Query Neighborhood Hits	1044	Target Neighborhood Hits	932	Shared Neighborhood Hits	222
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

VAV_MOUSE
NC score	0.075748 (rank : 1025)	θ value	θ > 10 (rank : 1442)
Query Neighborhood Hits	1044	Target Neighborhood Hits	430	Shared Neighborhood Hits	89
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GCC2_MOUSE
NC score	0.075746 (rank : 1026)	θ value	θ > 10 (rank : 1175)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1619	Shared Neighborhood Hits	250
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GOGA3_HUMAN
NC score	0.075647 (rank : 1027)	θ value	1.38821 (rank : 910)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1317	Shared Neighborhood Hits	228
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

SYCP1_HUMAN
NC score	0.075542 (rank : 1028)	θ value	θ > 10 (rank : 1392)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1313	Shared Neighborhood Hits	244
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

PHLB2_HUMAN
NC score	0.075469 (rank : 1029)	θ value	2.36792 (rank : 938)
Query Neighborhood Hits	1044	Target Neighborhood Hits	964	Shared Neighborhood Hits	223
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

RABE1_HUMAN
NC score	0.075452 (rank : 1030)	θ value	θ > 10 (rank : 1326)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1104	Shared Neighborhood Hits	224
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

P55G_MOUSE
NC score	0.075425 (rank : 1031)	θ value	θ > 10 (rank : 1294)
Query Neighborhood Hits	1044	Target Neighborhood Hits	401	Shared Neighborhood Hits	154
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

BRE1A_MOUSE
NC score	0.075289 (rank : 1032)	θ value	0.0961366 (rank : 811)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1025	Shared Neighborhood Hits	194
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CCD39_HUMAN
NC score	0.075086 (rank : 1033)	θ value	3.0926 (rank : 943)
Query Neighborhood Hits	1044	Target Neighborhood Hits	868	Shared Neighborhood Hits	204
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

SM1L2_MOUSE
NC score	0.074932 (rank : 1034)	θ value	6.88961 (rank : 1006)
Query Neighborhood Hits	1044	Target Neighborhood Hits	918	Shared Neighborhood Hits	216
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

OPTN_MOUSE
NC score	0.074653 (rank : 1035)	θ value	θ > 10 (rank : 1292)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1120	Shared Neighborhood Hits	235
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

PEPL_MOUSE
NC score	0.074270 (rank : 1036)	θ value	θ > 10 (rank : 1302)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1105	Shared Neighborhood Hits	228
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

NEMO_HUMAN
NC score	0.074227 (rank : 1037)	θ value	θ > 10 (rank : 1279)
Query Neighborhood Hits	1044	Target Neighborhood Hits	820	Shared Neighborhood Hits	205
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

RASF1_MOUSE
NC score	0.074171 (rank : 1038)	θ value	θ > 10 (rank : 1333)
Query Neighborhood Hits	1044	Target Neighborhood Hits	74	Shared Neighborhood Hits	32
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

TAXB1_MOUSE
NC score	0.074155 (rank : 1039)	θ value	θ > 10 (rank : 1401)
Query Neighborhood Hits	1044	Target Neighborhood Hits	886	Shared Neighborhood Hits	207
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

SM1L2_HUMAN
NC score	0.074123 (rank : 1040)	θ value	θ > 10 (rank : 1371)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1019	Shared Neighborhood Hits	222
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

CIP4_HUMAN
NC score	0.074068 (rank : 1041)	θ value	θ > 10 (rank : 1122)
Query Neighborhood Hits	1044	Target Neighborhood Hits	374	Shared Neighborhood Hits	144
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CCD45_HUMAN
NC score	0.074063 (rank : 1042)	θ value	θ > 10 (rank : 1089)
Query Neighborhood Hits	1044	Target Neighborhood Hits	525	Shared Neighborhood Hits	180
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCD27_HUMAN
NC score	0.073829 (rank : 1043)	θ value	0.0148317 (rank : 770)
Query Neighborhood Hits	1044	Target Neighborhood Hits	594	Shared Neighborhood Hits	170
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CHIO_HUMAN
NC score	0.073806 (rank : 1044)	θ value	θ > 10 (rank : 1118)
Query Neighborhood Hits	1044	Target Neighborhood Hits	220	Shared Neighborhood Hits	62
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

FLIP1_MOUSE
NC score	0.073699 (rank : 1045)	θ value	3.0926 (rank : 946)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1176	Shared Neighborhood Hits	236
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

SMC2_HUMAN
NC score	0.073661 (rank : 1046)	θ value	θ > 10 (rank : 1372)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1405	Shared Neighborhood Hits	246
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

CHIN_MOUSE
NC score	0.073621 (rank : 1047)	θ value	θ > 10 (rank : 1117)
Query Neighborhood Hits	1044	Target Neighborhood Hits	229	Shared Neighborhood Hits	65
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

ZN291_HUMAN
NC score	0.073589 (rank : 1048)	θ value	3.0926 (rank : 959)
Query Neighborhood Hits	1044	Target Neighborhood Hits	647	Shared Neighborhood Hits	170
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

CENPE_HUMAN
NC score	0.073526 (rank : 1049)	θ value	0.0431538 (rank : 794)
Query Neighborhood Hits	1044	Target Neighborhood Hits	2060	Shared Neighborhood Hits	284
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

PDZD8_HUMAN
NC score	0.073505 (rank : 1050)	θ value	θ > 10 (rank : 1301)
Query Neighborhood Hits	1044	Target Neighborhood Hits	185	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

AZI1_MOUSE
NC score	0.073498 (rank : 1051)	θ value	θ > 10 (rank : 1066)
Query Neighborhood Hits	1044	Target Neighborhood Hits	990	Shared Neighborhood Hits	220
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

NDE1_HUMAN
NC score	0.073492 (rank : 1052)	θ value	6.88961 (rank : 1003)
Query Neighborhood Hits	1044	Target Neighborhood Hits	823	Shared Neighborhood Hits	214
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

NUMA1_HUMAN
NC score	0.073447 (rank : 1053)	θ value	0.279714 (rank : 851)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1523	Shared Neighborhood Hits	240
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

KMHN1_HUMAN
NC score	0.073431 (rank : 1054)	θ value	θ > 10 (rank : 1226)
Query Neighborhood Hits	1044	Target Neighborhood Hits	950	Shared Neighborhood Hits	220
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

NAF1_HUMAN
NC score	0.073075 (rank : 1055)	θ value	θ > 10 (rank : 1275)
Query Neighborhood Hits	1044	Target Neighborhood Hits	937	Shared Neighborhood Hits	217
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

KMHN1_MOUSE
NC score	0.072921 (rank : 1056)	θ value	8.99809 (rank : 1033)
Query Neighborhood Hits	1044	Target Neighborhood Hits	949	Shared Neighborhood Hits	212
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

CK5P2_MOUSE
NC score	0.072886 (rank : 1057)	θ value	θ > 10 (rank : 1124)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1151	Shared Neighborhood Hits	230
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

BRE1A_HUMAN
NC score	0.072687 (rank : 1058)	θ value	0.47712 (rank : 860)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1071	Shared Neighborhood Hits	198
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

LUZP1_MOUSE
NC score	0.072468 (rank : 1059)	θ value	1.81305 (rank : 925)
Query Neighborhood Hits	1044	Target Neighborhood Hits	940	Shared Neighborhood Hits	208
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

CF152_HUMAN
NC score	0.072463 (rank : 1060)	θ value	θ > 10 (rank : 1111)
Query Neighborhood Hits	1044	Target Neighborhood Hits	704	Shared Neighborhood Hits	201
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CHIN_HUMAN
NC score	0.072439 (rank : 1061)	θ value	θ > 10 (rank : 1116)
Query Neighborhood Hits	1044	Target Neighborhood Hits	227	Shared Neighborhood Hits	63
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

IFT74_HUMAN
NC score	0.072434 (rank : 1062)	θ value	θ > 10 (rank : 1209)
Query Neighborhood Hits	1044	Target Neighborhood Hits	949	Shared Neighborhood Hits	209
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

EVPL_HUMAN
NC score	0.072297 (rank : 1063)	θ value	0.279714 (rank : 845)
Query Neighborhood Hits	1044	Target Neighborhood Hits	895	Shared Neighborhood Hits	214
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

TAXB1_HUMAN
NC score	0.072198 (rank : 1064)	θ value	θ > 10 (rank : 1400)
Query Neighborhood Hits	1044	Target Neighborhood Hits	829	Shared Neighborhood Hits	205
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

CF182_MOUSE
NC score	0.072034 (rank : 1065)	θ value	θ > 10 (rank : 1114)
Query Neighborhood Hits	1044	Target Neighborhood Hits	551	Shared Neighborhood Hits	185
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

MYO5B_HUMAN
NC score	0.072003 (rank : 1066)	θ value	θ > 10 (rank : 1263)
Query Neighborhood Hits	1044	Target Neighborhood Hits	911	Shared Neighborhood Hits	212
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

LRC45_HUMAN
NC score	0.071913 (rank : 1067)	θ value	θ > 10 (rank : 1235)
Query Neighborhood Hits	1044	Target Neighborhood Hits	933	Shared Neighborhood Hits	221
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

GOGA2_MOUSE
NC score	0.071783 (rank : 1068)	θ value	θ > 10 (rank : 1180)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	204
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

MYO10_HUMAN
NC score	0.071743 (rank : 1069)	θ value	6.88961 (rank : 1002)
Query Neighborhood Hits	1044	Target Neighborhood Hits	920	Shared Neighborhood Hits	213
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CCD13_HUMAN
NC score	0.071668 (rank : 1070)	θ value	θ > 10 (rank : 1082)
Query Neighborhood Hits	1044	Target Neighborhood Hits	721	Shared Neighborhood Hits	186
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

RBCC1_HUMAN
NC score	0.071648 (rank : 1071)	θ value	θ > 10 (rank : 1335)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1023	Shared Neighborhood Hits	222
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

TXLNB_HUMAN
NC score	0.071580 (rank : 1072)	θ value	0.00665767 (rank : 760)
Query Neighborhood Hits	1044	Target Neighborhood Hits	912	Shared Neighborhood Hits	184
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

HIP1_HUMAN
NC score	0.071536 (rank : 1073)	θ value	θ > 10 (rank : 1198)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1016	Shared Neighborhood Hits	227
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

CCHCR_HUMAN
NC score	0.071335 (rank : 1074)	θ value	θ > 10 (rank : 1098)
Query Neighborhood Hits	1044	Target Neighborhood Hits	717	Shared Neighborhood Hits	183
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

CK5P2_HUMAN
NC score	0.071316 (rank : 1075)	θ value	θ > 10 (rank : 1123)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1433	Shared Neighborhood Hits	245
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

DGKH_HUMAN
NC score	0.071252 (rank : 1076)	θ value	θ > 10 (rank : 1155)
Query Neighborhood Hits	1044	Target Neighborhood Hits	255	Shared Neighborhood Hits	69
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

CCD21_HUMAN
NC score	0.071168 (rank : 1077)	θ value	θ > 10 (rank : 1083)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1228	Shared Neighborhood Hits	231
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

IF3A_MOUSE
NC score	0.071015 (rank : 1078)	θ value	θ > 10 (rank : 1208)
Query Neighborhood Hits	1044	Target Neighborhood Hits	871	Shared Neighborhood Hits	204
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

CJ118_HUMAN
NC score	0.070913 (rank : 1079)	θ value	0.813845 (rank : 883)
Query Neighborhood Hits	1044	Target Neighborhood Hits	937	Shared Neighborhood Hits	197
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

RBCC1_MOUSE
NC score	0.070896 (rank : 1080)	θ value	θ > 10 (rank : 1336)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1048	Shared Neighborhood Hits	220
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

REN3B_HUMAN
NC score	0.070885 (rank : 1081)	θ value	0.0252991 (rank : 789)
Query Neighborhood Hits	1044	Target Neighborhood Hits	412	Shared Neighborhood Hits	114
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

ANR26_MOUSE
NC score	0.070871 (rank : 1082)	θ value	θ > 10 (rank : 1060)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1554	Shared Neighborhood Hits	248
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CCDC6_HUMAN
NC score	0.070859 (rank : 1083)	θ value	θ > 10 (rank : 1097)
Query Neighborhood Hits	1044	Target Neighborhood Hits	723	Shared Neighborhood Hits	204
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

DAPP1_HUMAN
NC score	0.070786 (rank : 1084)	θ value	θ > 10 (rank : 1148)
Query Neighborhood Hits	1044	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

LIPA1_HUMAN
NC score	0.070718 (rank : 1085)	θ value	3.0926 (rank : 949)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1294	Shared Neighborhood Hits	242
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

IF3A_HUMAN
NC score	0.070682 (rank : 1086)	θ value	θ > 10 (rank : 1207)
Query Neighborhood Hits	1044	Target Neighborhood Hits	875	Shared Neighborhood Hits	206
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

EEA1_HUMAN
NC score	0.070487 (rank : 1087)	θ value	8.99809 (rank : 1028)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1796	Shared Neighborhood Hits	256
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EEA1_MOUSE
NC score	0.070296 (rank : 1088)	θ value	1.81305 (rank : 920)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1637	Shared Neighborhood Hits	254
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

PLCB4_HUMAN
NC score	0.070223 (rank : 1089)	θ value	0.62314 (rank : 877)
Query Neighborhood Hits	1044	Target Neighborhood Hits	658	Shared Neighborhood Hits	204
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

SAS6_MOUSE
NC score	0.069903 (rank : 1090)	θ value	θ > 10 (rank : 1356)
Query Neighborhood Hits	1044	Target Neighborhood Hits	931	Shared Neighborhood Hits	208
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

UACA_HUMAN
NC score	0.069787 (rank : 1091)	θ value	6.88961 (rank : 1010)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1622	Shared Neighborhood Hits	244
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

DAPP1_MOUSE
NC score	0.069688 (rank : 1092)	θ value	θ > 10 (rank : 1149)
Query Neighborhood Hits	1044	Target Neighborhood Hits	225	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CCD96_MOUSE
NC score	0.069603 (rank : 1093)	θ value	θ > 10 (rank : 1096)
Query Neighborhood Hits	1044	Target Neighborhood Hits	704	Shared Neighborhood Hits	190
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

GOG8A_HUMAN
NC score	0.069390 (rank : 1094)	θ value	5.27518 (rank : 979)
Query Neighborhood Hits	1044	Target Neighborhood Hits	635	Shared Neighborhood Hits	195
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

UN13A_HUMAN
NC score	0.069301 (rank : 1095)	θ value	θ > 10 (rank : 1434)
Query Neighborhood Hits	1044	Target Neighborhood Hits	285	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

TNIP3_HUMAN
NC score	0.069136 (rank : 1096)	θ value	0.813845 (rank : 890)
Query Neighborhood Hits	1044	Target Neighborhood Hits	511	Shared Neighborhood Hits	167
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

CASP_MOUSE
NC score	0.069110 (rank : 1097)	θ value	θ > 10 (rank : 1079)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1152	Shared Neighborhood Hits	227
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CASP_HUMAN
NC score	0.069050 (rank : 1098)	θ value	θ > 10 (rank : 1078)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1131	Shared Neighborhood Hits	226
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

ANR26_HUMAN
NC score	0.068897 (rank : 1099)	θ value	θ > 10 (rank : 1059)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1614	Shared Neighborhood Hits	251
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

HIP1R_MOUSE
NC score	0.068859 (rank : 1100)	θ value	θ > 10 (rank : 1197)
Query Neighborhood Hits	1044	Target Neighborhood Hits	959	Shared Neighborhood Hits	217
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

MYO6_HUMAN
NC score	0.068492 (rank : 1101)	θ value	θ > 10 (rank : 1265)
Query Neighborhood Hits	1044	Target Neighborhood Hits	727	Shared Neighborhood Hits	181
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

CCD93_HUMAN
NC score	0.068423 (rank : 1102)	θ value	θ > 10 (rank : 1093)
Query Neighborhood Hits	1044	Target Neighborhood Hits	600	Shared Neighborhood Hits	179
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

OFD1_HUMAN
NC score	0.068414 (rank : 1103)	θ value	θ > 10 (rank : 1290)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	194
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

RIMB1_HUMAN
NC score	0.068398 (rank : 1104)	θ value	θ > 10 (rank : 1342)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1479	Shared Neighborhood Hits	261
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

UN13B_HUMAN
NC score	0.068113 (rank : 1105)	θ value	θ > 10 (rank : 1435)
Query Neighborhood Hits	1044	Target Neighborhood Hits	217	Shared Neighborhood Hits	47
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CEP70_MOUSE
NC score	0.067977 (rank : 1106)	θ value	θ > 10 (rank : 1110)
Query Neighborhood Hits	1044	Target Neighborhood Hits	532	Shared Neighborhood Hits	177
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

NEMO_MOUSE
NC score	0.067952 (rank : 1107)	θ value	θ > 10 (rank : 1280)
Query Neighborhood Hits	1044	Target Neighborhood Hits	658	Shared Neighborhood Hits	187
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

CEP70_HUMAN
NC score	0.067895 (rank : 1108)	θ value	θ > 10 (rank : 1109)
Query Neighborhood Hits	1044	Target Neighborhood Hits	432	Shared Neighborhood Hits	160
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

CEP55_HUMAN
NC score	0.067635 (rank : 1109)	θ value	θ > 10 (rank : 1105)
Query Neighborhood Hits	1044	Target Neighborhood Hits	504	Shared Neighborhood Hits	173
SwissProt Accessions	Q53EZ4, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7	Gene names	CEP55, C10orf3, URCC6
Domain Architecture	No domain graphic available
Description	Centrosome protein 55 (Up-regulated in colon cancer 6).

LIPA2_MOUSE
NC score	0.067405 (rank : 1110)	θ value	θ > 10 (rank : 1232)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1282	Shared Neighborhood Hits	238
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

CN145_MOUSE
NC score	0.067264 (rank : 1111)	θ value	θ > 10 (rank : 1127)
Query Neighborhood Hits	1044	Target Neighborhood Hits	916	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

MYO6_MOUSE
NC score	0.067247 (rank : 1112)	θ value	θ > 10 (rank : 1266)
Query Neighborhood Hits	1044	Target Neighborhood Hits	586	Shared Neighborhood Hits	165
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

HOOK1_MOUSE
NC score	0.067081 (rank : 1113)	θ value	θ > 10 (rank : 1200)
Query Neighborhood Hits	1044	Target Neighborhood Hits	910	Shared Neighborhood Hits	204
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

MPP9_HUMAN
NC score	0.067006 (rank : 1114)	θ value	θ > 10 (rank : 1256)
Query Neighborhood Hits	1044	Target Neighborhood Hits	529	Shared Neighborhood Hits	167
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

ENAH_HUMAN
NC score	0.066902 (rank : 1115)	θ value	0.0961366 (rank : 814)
Query Neighborhood Hits	1044	Target Neighborhood Hits	784	Shared Neighborhood Hits	175
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

CCD96_HUMAN
NC score	0.066694 (rank : 1116)	θ value	θ > 10 (rank : 1095)
Query Neighborhood Hits	1044	Target Neighborhood Hits	595	Shared Neighborhood Hits	177
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

IFT74_MOUSE
NC score	0.066571 (rank : 1117)	θ value	θ > 10 (rank : 1210)
Query Neighborhood Hits	1044	Target Neighborhood Hits	939	Shared Neighborhood Hits	208
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

KTN1_HUMAN
NC score	0.066480 (rank : 1118)	θ value	θ > 10 (rank : 1229)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1197	Shared Neighborhood Hits	220
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

TMF1_HUMAN
NC score	0.066420 (rank : 1119)	θ value	θ > 10 (rank : 1410)
Query Neighborhood Hits	1044	Target Neighborhood Hits	987	Shared Neighborhood Hits	204
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

LUZP1_HUMAN
NC score	0.066244 (rank : 1120)	θ value	θ > 10 (rank : 1240)
Query Neighborhood Hits	1044	Target Neighborhood Hits	739	Shared Neighborhood Hits	183
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

GCC1_HUMAN
NC score	0.066023 (rank : 1121)	θ value	θ > 10 (rank : 1172)
Query Neighborhood Hits	1044	Target Neighborhood Hits	887	Shared Neighborhood Hits	206
SwissProt Accessions	Q96CN9, Q9H6N7	Gene names	GCC1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

INVO_MOUSE
NC score	0.065946 (rank : 1122)	θ value	θ > 10 (rank : 1221)
Query Neighborhood Hits	1044	Target Neighborhood Hits	474	Shared Neighborhood Hits	136
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

UN13B_MOUSE
NC score	0.065897 (rank : 1123)	θ value	θ > 10 (rank : 1436)
Query Neighborhood Hits	1044	Target Neighborhood Hits	210	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CEP55_MOUSE
NC score	0.065814 (rank : 1124)	θ value	θ > 10 (rank : 1106)
Query Neighborhood Hits	1044	Target Neighborhood Hits	693	Shared Neighborhood Hits	191
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

AN30A_HUMAN
NC score	0.065641 (rank : 1125)	θ value	θ > 10 (rank : 1058)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1119	Shared Neighborhood Hits	218
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

DCX_HUMAN
NC score	0.065469 (rank : 1126)	θ value	θ > 10 (rank : 1150)
Query Neighborhood Hits	1044	Target Neighborhood Hits	141	Shared Neighborhood Hits	19
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

PLEC1_HUMAN
NC score	0.065453 (rank : 1127)	θ value	0.00665767 (rank : 759)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1326	Shared Neighborhood Hits	215
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

CNTRB_HUMAN
NC score	0.065411 (rank : 1128)	θ value	θ > 10 (rank : 1128)
Query Neighborhood Hits	1044	Target Neighborhood Hits	690	Shared Neighborhood Hits	179
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

EVPL_MOUSE
NC score	0.065256 (rank : 1129)	θ value	θ > 10 (rank : 1166)
Query Neighborhood Hits	1044	Target Neighborhood Hits	952	Shared Neighborhood Hits	215
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

RFIP3_HUMAN
NC score	0.065248 (rank : 1130)	θ value	θ > 10 (rank : 1339)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1055	Shared Neighborhood Hits	220
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

BICD2_MOUSE
NC score	0.065112 (rank : 1131)	θ value	θ > 10 (rank : 1070)
Query Neighborhood Hits	1044	Target Neighborhood Hits	864	Shared Neighborhood Hits	196
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_HUMAN
NC score	0.064886 (rank : 1132)	θ value	θ > 10 (rank : 1069)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	201
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

TXLNA_MOUSE
NC score	0.064828 (rank : 1133)	θ value	θ > 10 (rank : 1428)
Query Neighborhood Hits	1044	Target Neighborhood Hits	846	Shared Neighborhood Hits	200
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

HOOK1_HUMAN
NC score	0.064805 (rank : 1134)	θ value	4.03905 (rank : 964)
Query Neighborhood Hits	1044	Target Neighborhood Hits	942	Shared Neighborhood Hits	206
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

CEP57_MOUSE
NC score	0.064661 (rank : 1135)	θ value	8.99809 (rank : 1022)
Query Neighborhood Hits	1044	Target Neighborhood Hits	580	Shared Neighborhood Hits	195
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

CRKL_MOUSE
NC score	0.064530 (rank : 1136)	θ value	θ > 10 (rank : 1134)
Query Neighborhood Hits	1044	Target Neighborhood Hits	307	Shared Neighborhood Hits	52
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

C102B_HUMAN
NC score	0.064507 (rank : 1137)	θ value	5.27518 (rank : 976)
Query Neighborhood Hits	1044	Target Neighborhood Hits	542	Shared Neighborhood Hits	159
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

CR034_MOUSE
NC score	0.064429 (rank : 1138)	θ value	5.27518 (rank : 978)
Query Neighborhood Hits	1044	Target Neighborhood Hits	643	Shared Neighborhood Hits	174
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

PACE1_MOUSE
NC score	0.064360 (rank : 1139)	θ value	θ > 10 (rank : 1300)
Query Neighborhood Hits	1044	Target Neighborhood Hits	92	Shared Neighborhood Hits	53
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

CEP57_HUMAN
NC score	0.064159 (rank : 1140)	θ value	θ > 10 (rank : 1107)
Query Neighborhood Hits	1044	Target Neighborhood Hits	576	Shared Neighborhood Hits	194
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

ZWINT_MOUSE
NC score	0.064149 (rank : 1141)	θ value	θ > 10 (rank : 1455)
Query Neighborhood Hits	1044	Target Neighborhood Hits	497	Shared Neighborhood Hits	172
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

GOGA2_HUMAN
NC score	0.063987 (rank : 1142)	θ value	θ > 10 (rank : 1179)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	193
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

HOOK3_HUMAN
NC score	0.063964 (rank : 1143)	θ value	θ > 10 (rank : 1203)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1070	Shared Neighborhood Hits	218
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

NUF2_HUMAN
NC score	0.063880 (rank : 1144)	θ value	θ > 10 (rank : 1288)
Query Neighborhood Hits	1044	Target Neighborhood Hits	661	Shared Neighborhood Hits	176
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

TACC2_HUMAN
NC score	0.063861 (rank : 1145)	θ value	θ > 10 (rank : 1397)
Query Neighborhood Hits	1044	Target Neighborhood Hits	856	Shared Neighborhood Hits	206
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

PININ_HUMAN
NC score	0.063839 (rank : 1146)	θ value	θ > 10 (rank : 1312)
Query Neighborhood Hits	1044	Target Neighborhood Hits	753	Shared Neighborhood Hits	182
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

NEST_HUMAN
NC score	0.063772 (rank : 1147)	θ value	θ > 10 (rank : 1283)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1305	Shared Neighborhood Hits	227
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

LIPA2_HUMAN
NC score	0.063607 (rank : 1148)	θ value	8.99809 (rank : 1034)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1044	Shared Neighborhood Hits	223
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

AMOL2_HUMAN
NC score	0.063591 (rank : 1149)	θ value	θ > 10 (rank : 1056)
Query Neighborhood Hits	1044	Target Neighborhood Hits	603	Shared Neighborhood Hits	183
SwissProt Accessions	Q9Y2J4, Q53EP1, Q96F99, Q9UKB4	Gene names	AMOTL2, KIAA0989
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP).

SAS6_HUMAN
NC score	0.063575 (rank : 1150)	θ value	θ > 10 (rank : 1355)
Query Neighborhood Hits	1044	Target Neighborhood Hits	791	Shared Neighborhood Hits	187
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

BICD1_MOUSE
NC score	0.063479 (rank : 1151)	θ value	θ > 10 (rank : 1068)
Query Neighborhood Hits	1044	Target Neighborhood Hits	837	Shared Neighborhood Hits	194
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

RFIP4_MOUSE
NC score	0.063468 (rank : 1152)	θ value	3.0926 (rank : 954)
Query Neighborhood Hits	1044	Target Neighborhood Hits	708	Shared Neighborhood Hits	195
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

CHIO_MOUSE
NC score	0.063402 (rank : 1153)	θ value	θ > 10 (rank : 1119)
Query Neighborhood Hits	1044	Target Neighborhood Hits	130	Shared Neighborhood Hits	37
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SMC4_MOUSE
NC score	0.063394 (rank : 1154)	θ value	0.0148317 (rank : 775)
Query Neighborhood Hits	1044	Target Neighborhood Hits	830	Shared Neighborhood Hits	188
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

PININ_MOUSE
NC score	0.063337 (rank : 1155)	θ value	θ > 10 (rank : 1313)
Query Neighborhood Hits	1044	Target Neighborhood Hits	777	Shared Neighborhood Hits	182
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

RGNEF_MOUSE
NC score	0.063329 (rank : 1156)	θ value	θ > 10 (rank : 1341)
Query Neighborhood Hits	1044	Target Neighborhood Hits	641	Shared Neighborhood Hits	197
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

CCD27_MOUSE
NC score	0.063304 (rank : 1157)	θ value	θ > 10 (rank : 1085)
Query Neighborhood Hits	1044	Target Neighborhood Hits	461	Shared Neighborhood Hits	145
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

GCC1_MOUSE
NC score	0.063271 (rank : 1158)	θ value	θ > 10 (rank : 1173)
Query Neighborhood Hits	1044	Target Neighborhood Hits	777	Shared Neighborhood Hits	193
SwissProt Accessions	Q9D4H2, Q8CCR3	Gene names	Gcc1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

CRKL_HUMAN
NC score	0.063228 (rank : 1159)	θ value	θ > 10 (rank : 1133)
Query Neighborhood Hits	1044	Target Neighborhood Hits	313	Shared Neighborhood Hits	52
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

HOOK3_MOUSE
NC score	0.063135 (rank : 1160)	θ value	θ > 10 (rank : 1204)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1007	Shared Neighborhood Hits	214
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

CR034_HUMAN
NC score	0.063083 (rank : 1161)	θ value	θ > 10 (rank : 1131)
Query Neighborhood Hits	1044	Target Neighborhood Hits	538	Shared Neighborhood Hits	159
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

BICD1_HUMAN
NC score	0.062970 (rank : 1162)	θ value	θ > 10 (rank : 1067)
Query Neighborhood Hits	1044	Target Neighborhood Hits	844	Shared Neighborhood Hits	194
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

PLCG1_MOUSE
NC score	0.062875 (rank : 1163)	θ value	θ > 10 (rank : 1315)
Query Neighborhood Hits	1044	Target Neighborhood Hits	314	Shared Neighborhood Hits	64
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DGKQ_HUMAN
NC score	0.062874 (rank : 1164)	θ value	θ > 10 (rank : 1156)
Query Neighborhood Hits	1044	Target Neighborhood Hits	131	Shared Neighborhood Hits	35
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

FYCO1_HUMAN
NC score	0.062800 (rank : 1165)	θ value	0.813845 (rank : 884)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1149	Shared Neighborhood Hits	221
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

HSH2D_HUMAN
NC score	0.062772 (rank : 1166)	θ value	θ > 10 (rank : 1205)
Query Neighborhood Hits	1044	Target Neighborhood Hits	159	Shared Neighborhood Hits	40
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

TXLNA_HUMAN
NC score	0.062538 (rank : 1167)	θ value	θ > 10 (rank : 1427)
Query Neighborhood Hits	1044	Target Neighborhood Hits	982	Shared Neighborhood Hits	193
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

SKIL_MOUSE
NC score	0.062464 (rank : 1168)	θ value	1.06291 (rank : 902)
Query Neighborhood Hits	1044	Target Neighborhood Hits	719	Shared Neighborhood Hits	196
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

LRRF2_MOUSE
NC score	0.062458 (rank : 1169)	θ value	θ > 10 (rank : 1237)
Query Neighborhood Hits	1044	Target Neighborhood Hits	556	Shared Neighborhood Hits	175
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

DCX_MOUSE
NC score	0.062442 (rank : 1170)	θ value	θ > 10 (rank : 1151)
Query Neighborhood Hits	1044	Target Neighborhood Hits	124	Shared Neighborhood Hits	12
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

HOOK2_HUMAN
NC score	0.062375 (rank : 1171)	θ value	θ > 10 (rank : 1201)
Query Neighborhood Hits	1044	Target Neighborhood Hits	714	Shared Neighborhood Hits	191
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

RUFY1_HUMAN
NC score	0.062314 (rank : 1172)	θ value	0.163984 (rank : 829)
Query Neighborhood Hits	1044	Target Neighborhood Hits	848	Shared Neighborhood Hits	203
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

PLCG1_HUMAN
NC score	0.062262 (rank : 1173)	θ value	θ > 10 (rank : 1314)
Query Neighborhood Hits	1044	Target Neighborhood Hits	293	Shared Neighborhood Hits	61
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MAP1A_HUMAN
NC score	0.062159 (rank : 1174)	θ value	6.88961 (rank : 1001)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1626	Shared Neighborhood Hits	258
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

KIF4A_HUMAN
NC score	0.061801 (rank : 1175)	θ value	0.279714 (rank : 849)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1159	Shared Neighborhood Hits	231
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

TUFT1_HUMAN
NC score	0.061743 (rank : 1176)	θ value	θ > 10 (rank : 1425)
Query Neighborhood Hits	1044	Target Neighborhood Hits	686	Shared Neighborhood Hits	191
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

RASF1_HUMAN
NC score	0.061588 (rank : 1177)	θ value	θ > 10 (rank : 1332)
Query Neighborhood Hits	1044	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

HOOK2_MOUSE
NC score	0.061582 (rank : 1178)	θ value	θ > 10 (rank : 1202)
Query Neighborhood Hits	1044	Target Neighborhood Hits	736	Shared Neighborhood Hits	193
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

PACE1_HUMAN
NC score	0.061390 (rank : 1179)	θ value	θ > 10 (rank : 1299)
Query Neighborhood Hits	1044	Target Neighborhood Hits	74	Shared Neighborhood Hits	47
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

CCD42_HUMAN
NC score	0.061287 (rank : 1180)	θ value	θ > 10 (rank : 1088)
Query Neighborhood Hits	1044	Target Neighborhood Hits	406	Shared Neighborhood Hits	151
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

TXLNG_MOUSE
NC score	0.061279 (rank : 1181)	θ value	θ > 10 (rank : 1431)
Query Neighborhood Hits	1044	Target Neighborhood Hits	552	Shared Neighborhood Hits	155
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

FYCO1_MOUSE
NC score	0.061254 (rank : 1182)	θ value	θ > 10 (rank : 1169)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1059	Shared Neighborhood Hits	215
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

LRRF2_HUMAN
NC score	0.061241 (rank : 1183)	θ value	θ > 10 (rank : 1236)
Query Neighborhood Hits	1044	Target Neighborhood Hits	791	Shared Neighborhood Hits	196
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

OPTN_HUMAN
NC score	0.061172 (rank : 1184)	θ value	θ > 10 (rank : 1291)
Query Neighborhood Hits	1044	Target Neighborhood Hits	827	Shared Neighborhood Hits	201
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

TEX9_MOUSE
NC score	0.061152 (rank : 1185)	θ value	θ > 10 (rank : 1407)
Query Neighborhood Hits	1044	Target Neighborhood Hits	581	Shared Neighborhood Hits	175
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

RRBP1_HUMAN
NC score	0.061140 (rank : 1186)	θ value	1.38821 (rank : 916)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1306	Shared Neighborhood Hits	226
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

WDR67_HUMAN
NC score	0.061099 (rank : 1187)	θ value	θ > 10 (rank : 1452)
Query Neighborhood Hits	1044	Target Neighborhood Hits	782	Shared Neighborhood Hits	201
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

RFIP4_HUMAN
NC score	0.061074 (rank : 1188)	θ value	θ > 10 (rank : 1340)
Query Neighborhood Hits	1044	Target Neighborhood Hits	785	Shared Neighborhood Hits	197
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

CF182_HUMAN
NC score	0.061069 (rank : 1189)	θ value	θ > 10 (rank : 1113)
Query Neighborhood Hits	1044	Target Neighborhood Hits	474	Shared Neighborhood Hits	166
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

TCRG1_MOUSE
NC score	0.060982 (rank : 1190)	θ value	θ > 10 (rank : 1403)
Query Neighborhood Hits	1044	Target Neighborhood Hits	947	Shared Neighborhood Hits	203
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

ADIP_HUMAN
NC score	0.060944 (rank : 1191)	θ value	θ > 10 (rank : 1051)
Query Neighborhood Hits	1044	Target Neighborhood Hits	470	Shared Neighborhood Hits	163
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

CF152_MOUSE
NC score	0.060943 (rank : 1192)	θ value	θ > 10 (rank : 1112)
Query Neighborhood Hits	1044	Target Neighborhood Hits	597	Shared Neighborhood Hits	177
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

AL2SB_HUMAN
NC score	0.060886 (rank : 1193)	θ value	θ > 10 (rank : 1054)
Query Neighborhood Hits	1044	Target Neighborhood Hits	294	Shared Neighborhood Hits	112
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

SMC4_HUMAN
NC score	0.060762 (rank : 1194)	θ value	θ > 10 (rank : 1374)
Query Neighborhood Hits	1044	Target Neighborhood Hits	937	Shared Neighborhood Hits	203
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

T3JAM_HUMAN
NC score	0.060746 (rank : 1195)	θ value	θ > 10 (rank : 1395)
Query Neighborhood Hits	1044	Target Neighborhood Hits	533	Shared Neighborhood Hits	159
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

EP15R_HUMAN
NC score	0.060562 (rank : 1196)	θ value	θ > 10 (rank : 1162)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1083	Shared Neighborhood Hits	220
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

BPAEA_HUMAN
NC score	0.060518 (rank : 1197)	θ value	0.163984 (rank : 823)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1369	Shared Neighborhood Hits	223
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

MACOI_MOUSE
NC score	0.060498 (rank : 1198)	θ value	θ > 10 (rank : 1247)
Query Neighborhood Hits	1044	Target Neighborhood Hits	620	Shared Neighborhood Hits	180
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MACF4_HUMAN
NC score	0.060455 (rank : 1199)	θ value	θ > 10 (rank : 1245)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1321	Shared Neighborhood Hits	221
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

TPM3_HUMAN
NC score	0.060338 (rank : 1200)	θ value	0.813845 (rank : 891)
Query Neighborhood Hits	1044	Target Neighborhood Hits	689	Shared Neighborhood Hits	169
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

CAR11_HUMAN
NC score	0.060304 (rank : 1201)	θ value	θ > 10 (rank : 1077)
Query Neighborhood Hits	1044	Target Neighborhood Hits	690	Shared Neighborhood Hits	196
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

MYO9B_MOUSE
NC score	0.060280 (rank : 1202)	θ value	θ > 10 (rank : 1270)
Query Neighborhood Hits	1044	Target Neighborhood Hits	311	Shared Neighborhood Hits	75
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.060192 (rank : 1203)	θ value	θ > 10 (rank : 1269)
Query Neighborhood Hits	1044	Target Neighborhood Hits	641	Shared Neighborhood Hits	106
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CAF1A_MOUSE
NC score	0.060140 (rank : 1204)	θ value	θ > 10 (rank : 1075)
Query Neighborhood Hits	1044	Target Neighborhood Hits	736	Shared Neighborhood Hits	181
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CENPJ_HUMAN
NC score	0.060134 (rank : 1205)	θ value	θ > 10 (rank : 1104)
Query Neighborhood Hits	1044	Target Neighborhood Hits	721	Shared Neighborhood Hits	199
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

RRBP1_MOUSE
NC score	0.060083 (rank : 1206)	θ value	θ > 10 (rank : 1349)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1650	Shared Neighborhood Hits	249
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

CYTSA_MOUSE
NC score	0.060076 (rank : 1207)	θ value	θ > 10 (rank : 1147)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1104	Shared Neighborhood Hits	223
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

3BP5_HUMAN
NC score	0.060057 (rank : 1208)	θ value	θ > 10 (rank : 1045)
Query Neighborhood Hits	1044	Target Neighborhood Hits	375	Shared Neighborhood Hits	132
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

SPAG5_MOUSE
NC score	0.059918 (rank : 1209)	θ value	θ > 10 (rank : 1376)
Query Neighborhood Hits	1044	Target Neighborhood Hits	612	Shared Neighborhood Hits	166
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

TXLNG_HUMAN
NC score	0.059911 (rank : 1210)	θ value	θ > 10 (rank : 1430)
Query Neighborhood Hits	1044	Target Neighborhood Hits	568	Shared Neighborhood Hits	154
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

KNTC2_MOUSE
NC score	0.059906 (rank : 1211)	θ value	θ > 10 (rank : 1228)
Query Neighborhood Hits	1044	Target Neighborhood Hits	692	Shared Neighborhood Hits	171
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

NPHP1_MOUSE
NC score	0.059875 (rank : 1212)	θ value	θ > 10 (rank : 1285)
Query Neighborhood Hits	1044	Target Neighborhood Hits	267	Shared Neighborhood Hits	67
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

RAI14_MOUSE
NC score	0.059820 (rank : 1213)	θ value	θ > 10 (rank : 1330)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1505	Shared Neighborhood Hits	229
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

POF1B_HUMAN
NC score	0.059809 (rank : 1214)	θ value	θ > 10 (rank : 1319)
Query Neighborhood Hits	1044	Target Neighborhood Hits	494	Shared Neighborhood Hits	156
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

SHE_HUMAN
NC score	0.059635 (rank : 1215)	θ value	θ > 10 (rank : 1365)
Query Neighborhood Hits	1044	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

TCRG1_HUMAN
NC score	0.059634 (rank : 1216)	θ value	θ > 10 (rank : 1402)
Query Neighborhood Hits	1044	Target Neighborhood Hits	929	Shared Neighborhood Hits	204
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

CAF1A_HUMAN
NC score	0.059606 (rank : 1217)	θ value	θ > 10 (rank : 1074)
Query Neighborhood Hits	1044	Target Neighborhood Hits	750	Shared Neighborhood Hits	178
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

PLCG2_HUMAN
NC score	0.059542 (rank : 1218)	θ value	θ > 10 (rank : 1316)
Query Neighborhood Hits	1044	Target Neighborhood Hits	280	Shared Neighborhood Hits	53
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SPTA2_HUMAN
NC score	0.059538 (rank : 1219)	θ value	θ > 10 (rank : 1380)
Query Neighborhood Hits	1044	Target Neighborhood Hits	888	Shared Neighborhood Hits	202
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

CYTSA_HUMAN
NC score	0.059469 (rank : 1220)	θ value	θ > 10 (rank : 1146)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1138	Shared Neighborhood Hits	226
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CEP35_HUMAN
NC score	0.059461 (rank : 1221)	θ value	1.38821 (rank : 906)
Query Neighborhood Hits	1044	Target Neighborhood Hits	811	Shared Neighborhood Hits	197
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CKAP4_MOUSE
NC score	0.059436 (rank : 1222)	θ value	θ > 10 (rank : 1126)
Query Neighborhood Hits	1044	Target Neighborhood Hits	596	Shared Neighborhood Hits	162
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

KINH_HUMAN
NC score	0.059428 (rank : 1223)	θ value	0.47712 (rank : 864)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1231	Shared Neighborhood Hits	240
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

APOA4_HUMAN
NC score	0.059350 (rank : 1224)	θ value	θ > 10 (rank : 1061)
Query Neighborhood Hits	1044	Target Neighborhood Hits	399	Shared Neighborhood Hits	125
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

MACOI_HUMAN
NC score	0.059221 (rank : 1225)	θ value	θ > 10 (rank : 1246)
Query Neighborhood Hits	1044	Target Neighborhood Hits	650	Shared Neighborhood Hits	185
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

GRB14_MOUSE
NC score	0.059167 (rank : 1226)	θ value	θ > 10 (rank : 1187)
Query Neighborhood Hits	1044	Target Neighborhood Hits	149	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ASPP2_HUMAN
NC score	0.059044 (rank : 1227)	θ value	θ > 10 (rank : 1064)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1156	Shared Neighborhood Hits	217
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SHE_MOUSE
NC score	0.059010 (rank : 1228)	θ value	θ > 10 (rank : 1366)
Query Neighborhood Hits	1044	Target Neighborhood Hits	169	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

KNTC2_HUMAN
NC score	0.059003 (rank : 1229)	θ value	θ > 10 (rank : 1227)
Query Neighborhood Hits	1044	Target Neighborhood Hits	673	Shared Neighborhood Hits	178
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

TPM1_MOUSE
NC score	0.058904 (rank : 1230)	θ value	θ > 10 (rank : 1415)
Query Neighborhood Hits	1044	Target Neighborhood Hits	729	Shared Neighborhood Hits	180
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM3_MOUSE
NC score	0.058845 (rank : 1231)	θ value	2.36792 (rank : 941)
Query Neighborhood Hits	1044	Target Neighborhood Hits	676	Shared Neighborhood Hits	168
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

RABE2_MOUSE
NC score	0.058712 (rank : 1232)	θ value	θ > 10 (rank : 1329)
Query Neighborhood Hits	1044	Target Neighborhood Hits	598	Shared Neighborhood Hits	177
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

GP73_MOUSE
NC score	0.058704 (rank : 1233)	θ value	θ > 10 (rank : 1181)
Query Neighborhood Hits	1044	Target Neighborhood Hits	506	Shared Neighborhood Hits	160
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

POF1B_MOUSE
NC score	0.058600 (rank : 1234)	θ value	θ > 10 (rank : 1320)
Query Neighborhood Hits	1044	Target Neighborhood Hits	530	Shared Neighborhood Hits	160
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

CDR2_MOUSE
NC score	0.058590 (rank : 1235)	θ value	θ > 10 (rank : 1101)
Query Neighborhood Hits	1044	Target Neighborhood Hits	482	Shared Neighborhood Hits	170
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

HOME2_MOUSE
NC score	0.058535 (rank : 1236)	θ value	θ > 10 (rank : 1199)
Query Neighborhood Hits	1044	Target Neighborhood Hits	882	Shared Neighborhood Hits	215
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

MYO1E_HUMAN
NC score	0.058514 (rank : 1237)	θ value	θ > 10 (rank : 1260)
Query Neighborhood Hits	1044	Target Neighborhood Hits	293	Shared Neighborhood Hits	65
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

TUFT1_MOUSE
NC score	0.058513 (rank : 1238)	θ value	θ > 10 (rank : 1426)
Query Neighborhood Hits	1044	Target Neighborhood Hits	732	Shared Neighborhood Hits	193
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

ZC313_HUMAN
NC score	0.058363 (rank : 1239)	θ value	θ > 10 (rank : 1453)
Query Neighborhood Hits	1044	Target Neighborhood Hits	772	Shared Neighborhood Hits	158
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

CCD93_MOUSE
NC score	0.058354 (rank : 1240)	θ value	θ > 10 (rank : 1094)
Query Neighborhood Hits	1044	Target Neighborhood Hits	362	Shared Neighborhood Hits	137
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

MYO1F_HUMAN
NC score	0.058281 (rank : 1241)	θ value	θ > 10 (rank : 1261)
Query Neighborhood Hits	1044	Target Neighborhood Hits	275	Shared Neighborhood Hits	66
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

GLE1_HUMAN
NC score	0.057968 (rank : 1242)	θ value	θ > 10 (rank : 1176)
Query Neighborhood Hits	1044	Target Neighborhood Hits	445	Shared Neighborhood Hits	157
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

RAI14_HUMAN
NC score	0.057963 (rank : 1243)	θ value	0.21417 (rank : 836)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1367	Shared Neighborhood Hits	227
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

SFR12_HUMAN
NC score	0.057897 (rank : 1244)	θ value	0.0113563 (rank : 768)
Query Neighborhood Hits	1044	Target Neighborhood Hits	553	Shared Neighborhood Hits	122
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

EP15R_MOUSE
NC score	0.057790 (rank : 1245)	θ value	θ > 10 (rank : 1163)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1135	Shared Neighborhood Hits	215
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

UBXD2_HUMAN
NC score	0.057690 (rank : 1246)	θ value	0.00390308 (rank : 750)
Query Neighborhood Hits	1044	Target Neighborhood Hits	241	Shared Neighborhood Hits	83
SwissProt Accessions	Q92575, Q8IYM5	Gene names	UBXD2, KIAA0242, UBXDC1
Domain Architecture
Description	UBX domain-containing protein 2.

CKAP4_HUMAN
NC score	0.057646 (rank : 1247)	θ value	θ > 10 (rank : 1125)
Query Neighborhood Hits	1044	Target Neighborhood Hits	592	Shared Neighborhood Hits	161
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

MYO1F_MOUSE
NC score	0.057615 (rank : 1248)	θ value	θ > 10 (rank : 1262)
Query Neighborhood Hits	1044	Target Neighborhood Hits	262	Shared Neighborhood Hits	64
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

RUFY2_HUMAN
NC score	0.057564 (rank : 1249)	θ value	5.27518 (rank : 987)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1208	Shared Neighborhood Hits	223
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

CUTL1_MOUSE
NC score	0.057529 (rank : 1250)	θ value	θ > 10 (rank : 1143)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1620	Shared Neighborhood Hits	243
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

MIPO1_HUMAN
NC score	0.057437 (rank : 1251)	θ value	θ > 10 (rank : 1254)
Query Neighborhood Hits	1044	Target Neighborhood Hits	486	Shared Neighborhood Hits	165
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

DLG5_HUMAN
NC score	0.057437 (rank : 1252)	θ value	θ > 10 (rank : 1157)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1088	Shared Neighborhood Hits	212
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

SAFB2_HUMAN
NC score	0.057368 (rank : 1253)	θ value	0.0113563 (rank : 767)
Query Neighborhood Hits	1044	Target Neighborhood Hits	720	Shared Neighborhood Hits	163
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

TPM1_HUMAN
NC score	0.057353 (rank : 1254)	θ value	θ > 10 (rank : 1414)
Query Neighborhood Hits	1044	Target Neighborhood Hits	716	Shared Neighborhood Hits	177
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

MFAP1_MOUSE
NC score	0.057257 (rank : 1255)	θ value	θ > 10 (rank : 1253)
Query Neighborhood Hits	1044	Target Neighborhood Hits	353	Shared Neighborhood Hits	120
SwissProt Accessions	Q9CQU1, Q3TU29, Q8CCL1, Q9CSJ5	Gene names	Mfap1
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 1.

TRAK1_HUMAN
NC score	0.057255 (rank : 1256)	θ value	θ > 10 (rank : 1422)
Query Neighborhood Hits	1044	Target Neighborhood Hits	660	Shared Neighborhood Hits	178
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

TEX9_HUMAN
NC score	0.057197 (rank : 1257)	θ value	θ > 10 (rank : 1406)
Query Neighborhood Hits	1044	Target Neighborhood Hits	541	Shared Neighborhood Hits	156
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

SYNE1_HUMAN
NC score	0.057184 (rank : 1258)	θ value	θ > 10 (rank : 1393)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1484	Shared Neighborhood Hits	235
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

NDE1_MOUSE
NC score	0.057136 (rank : 1259)	θ value	θ > 10 (rank : 1278)
Query Neighborhood Hits	1044	Target Neighborhood Hits	602	Shared Neighborhood Hits	180
SwissProt Accessions	Q9CZA6, Q3UBS6, Q3UIC1, Q9ERR0	Gene names	Nde1, Nude
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE) (mNudE).

TPM4_MOUSE
NC score	0.057103 (rank : 1260)	θ value	θ > 10 (rank : 1419)
Query Neighborhood Hits	1044	Target Neighborhood Hits	703	Shared Neighborhood Hits	185
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

APOE_MOUSE
NC score	0.057103 (rank : 1261)	θ value	θ > 10 (rank : 1063)
Query Neighborhood Hits	1044	Target Neighborhood Hits	319	Shared Neighborhood Hits	120
SwissProt Accessions	P08226	Gene names	Apoe
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

RUFY3_HUMAN
NC score	0.057090 (rank : 1262)	θ value	θ > 10 (rank : 1351)
Query Neighborhood Hits	1044	Target Neighborhood Hits	594	Shared Neighborhood Hits	180
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

TRAIP_HUMAN
NC score	0.057039 (rank : 1263)	θ value	θ > 10 (rank : 1420)
Query Neighborhood Hits	1044	Target Neighborhood Hits	780	Shared Neighborhood Hits	185
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

DMD_MOUSE
NC score	0.057032 (rank : 1264)	θ value	θ > 10 (rank : 1159)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1111	Shared Neighborhood Hits	219
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

RBBP8_HUMAN
NC score	0.056941 (rank : 1265)	θ value	θ > 10 (rank : 1334)
Query Neighborhood Hits	1044	Target Neighborhood Hits	476	Shared Neighborhood Hits	169
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

SMC2_MOUSE
NC score	0.056799 (rank : 1266)	θ value	θ > 10 (rank : 1373)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1131	Shared Neighborhood Hits	217
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

CUTL1_HUMAN
NC score	0.056791 (rank : 1267)	θ value	θ > 10 (rank : 1142)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1574	Shared Neighborhood Hits	241
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

IMMT_HUMAN
NC score	0.056750 (rank : 1268)	θ value	θ > 10 (rank : 1216)
Query Neighborhood Hits	1044	Target Neighborhood Hits	494	Shared Neighborhood Hits	156
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

SPTA1_HUMAN
NC score	0.056624 (rank : 1269)	θ value	θ > 10 (rank : 1378)
Query Neighborhood Hits	1044	Target Neighborhood Hits	748	Shared Neighborhood Hits	198
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RUFY3_MOUSE
NC score	0.056609 (rank : 1270)	θ value	θ > 10 (rank : 1352)
Query Neighborhood Hits	1044	Target Neighborhood Hits	579	Shared Neighborhood Hits	180
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

ADIP_MOUSE
NC score	0.056329 (rank : 1271)	θ value	θ > 10 (rank : 1052)
Query Neighborhood Hits	1044	Target Neighborhood Hits	415	Shared Neighborhood Hits	153
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

PHLB1_HUMAN
NC score	0.056263 (rank : 1272)	θ value	θ > 10 (rank : 1307)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1038	Shared Neighborhood Hits	217
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

MYOM1_HUMAN
NC score	0.056245 (rank : 1273)	θ value	θ > 10 (rank : 1271)
Query Neighborhood Hits	1044	Target Neighborhood Hits	405	Shared Neighborhood Hits	77
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

STIM1_HUMAN
NC score	0.056218 (rank : 1274)	θ value	θ > 10 (rank : 1385)
Query Neighborhood Hits	1044	Target Neighborhood Hits	665	Shared Neighborhood Hits	197
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

P85A_HUMAN
NC score	0.056211 (rank : 1275)	θ value	θ > 10 (rank : 1295)
Query Neighborhood Hits	1044	Target Neighborhood Hits	479	Shared Neighborhood Hits	138
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

GLE1_MOUSE
NC score	0.056116 (rank : 1276)	θ value	θ > 10 (rank : 1177)
Query Neighborhood Hits	1044	Target Neighborhood Hits	504	Shared Neighborhood Hits	158
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

CRCM_HUMAN
NC score	0.056084 (rank : 1277)	θ value	θ > 10 (rank : 1132)
Query Neighborhood Hits	1044	Target Neighborhood Hits	520	Shared Neighborhood Hits	157
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

IF2P_HUMAN
NC score	0.056042 (rank : 1278)	θ value	θ > 10 (rank : 1206)
Query Neighborhood Hits	1044	Target Neighborhood Hits	889	Shared Neighborhood Hits	170
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

HIP1R_HUMAN
NC score	0.056036 (rank : 1279)	θ value	θ > 10 (rank : 1196)
Query Neighborhood Hits	1044	Target Neighborhood Hits	809	Shared Neighborhood Hits	200
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

CT096_HUMAN
NC score	0.055760 (rank : 1280)	θ value	θ > 10 (rank : 1137)
Query Neighborhood Hits	1044	Target Neighborhood Hits	438	Shared Neighborhood Hits	153
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

TRAIP_MOUSE
NC score	0.055728 (rank : 1281)	θ value	θ > 10 (rank : 1421)
Query Neighborhood Hits	1044	Target Neighborhood Hits	745	Shared Neighborhood Hits	172
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

STIM1_MOUSE
NC score	0.055626 (rank : 1282)	θ value	θ > 10 (rank : 1386)
Query Neighborhood Hits	1044	Target Neighborhood Hits	660	Shared Neighborhood Hits	198
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

CTGE5_MOUSE
NC score	0.055623 (rank : 1283)	θ value	θ > 10 (rank : 1139)
Query Neighborhood Hits	1044	Target Neighborhood Hits	928	Shared Neighborhood Hits	205
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

TXLNB_MOUSE
NC score	0.055552 (rank : 1284)	θ value	θ > 10 (rank : 1429)
Query Neighborhood Hits	1044	Target Neighborhood Hits	640	Shared Neighborhood Hits	155
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

BPA1_MOUSE
NC score	0.055467 (rank : 1285)	θ value	8.99809 (rank : 1018)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1477	Shared Neighborhood Hits	240
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

DYNA_MOUSE
NC score	0.055376 (rank : 1286)	θ value	θ > 10 (rank : 1161)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1084	Shared Neighborhood Hits	215
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

ZWINT_HUMAN
NC score	0.055356 (rank : 1287)	θ value	6.88961 (rank : 1014)
Query Neighborhood Hits	1044	Target Neighborhood Hits	333	Shared Neighborhood Hits	141
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

DYNA_HUMAN
NC score	0.055310 (rank : 1288)	θ value	θ > 10 (rank : 1160)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1194	Shared Neighborhood Hits	219
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

NUF2_MOUSE
NC score	0.055272 (rank : 1289)	θ value	θ > 10 (rank : 1289)
Query Neighborhood Hits	1044	Target Neighborhood Hits	585	Shared Neighborhood Hits	173
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

CTGE5_HUMAN
NC score	0.055072 (rank : 1290)	θ value	4.03905 (rank : 962)
Query Neighborhood Hits	1044	Target Neighborhood Hits	800	Shared Neighborhood Hits	194
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

RUFY1_MOUSE
NC score	0.055053 (rank : 1291)	θ value	θ > 10 (rank : 1350)
Query Neighborhood Hits	1044	Target Neighborhood Hits	765	Shared Neighborhood Hits	176
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

LIPB1_MOUSE
NC score	0.054979 (rank : 1292)	θ value	θ > 10 (rank : 1234)
Query Neighborhood Hits	1044	Target Neighborhood Hits	727	Shared Neighborhood Hits	190
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

AMOL2_MOUSE
NC score	0.054925 (rank : 1293)	θ value	θ > 10 (rank : 1057)
Query Neighborhood Hits	1044	Target Neighborhood Hits	591	Shared Neighborhood Hits	169
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

RABE2_HUMAN
NC score	0.054863 (rank : 1294)	θ value	θ > 10 (rank : 1328)
Query Neighborhood Hits	1044	Target Neighborhood Hits	545	Shared Neighborhood Hits	169
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

PHLB3_HUMAN
NC score	0.054716 (rank : 1295)	θ value	θ > 10 (rank : 1308)
Query Neighborhood Hits	1044	Target Neighborhood Hits	304	Shared Neighborhood Hits	106
SwissProt Accessions	Q6NSJ2, Q8N7Z4	Gene names	PHLDB3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 3.

APOA4_MOUSE
NC score	0.054688 (rank : 1296)	θ value	θ > 10 (rank : 1062)
Query Neighborhood Hits	1044	Target Neighborhood Hits	435	Shared Neighborhood Hits	135
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

3BP5_MOUSE
NC score	0.054654 (rank : 1297)	θ value	θ > 10 (rank : 1046)
Query Neighborhood Hits	1044	Target Neighborhood Hits	346	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

HAP1_HUMAN
NC score	0.054588 (rank : 1298)	θ value	θ > 10 (rank : 1195)
Query Neighborhood Hits	1044	Target Neighborhood Hits	606	Shared Neighborhood Hits	184
SwissProt Accessions	P54257, O75358, Q9H4G3, Q9HA98, Q9NY90	Gene names	HAP1, HLP1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1).

DMD_HUMAN
NC score	0.054524 (rank : 1299)	θ value	θ > 10 (rank : 1158)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1135	Shared Neighborhood Hits	222
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

CTGE2_HUMAN
NC score	0.054331 (rank : 1300)	θ value	θ > 10 (rank : 1138)
Query Neighborhood Hits	1044	Target Neighborhood Hits	594	Shared Neighborhood Hits	167
SwissProt Accessions	Q96RT6	Gene names	CTAGE1, CTAGE2
Domain Architecture	No domain graphic available
Description	Protein cTAGE-2.

SPTA1_MOUSE
NC score	0.054324 (rank : 1301)	θ value	θ > 10 (rank : 1379)
Query Neighborhood Hits	1044	Target Neighborhood Hits	675	Shared Neighborhood Hits	188
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TPM2_MOUSE
NC score	0.054279 (rank : 1302)	θ value	θ > 10 (rank : 1417)
Query Neighborhood Hits	1044	Target Neighborhood Hits	676	Shared Neighborhood Hits	168
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

GCP60_MOUSE
NC score	0.054201 (rank : 1303)	θ value	1.38821 (rank : 908)
Query Neighborhood Hits	1044	Target Neighborhood Hits	395	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BMP6, O35371	Gene names	Acbd3, Gcp60, Pap7
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

TPM2_HUMAN
NC score	0.054172 (rank : 1304)	θ value	θ > 10 (rank : 1416)
Query Neighborhood Hits	1044	Target Neighborhood Hits	677	Shared Neighborhood Hits	163
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

MYOM1_MOUSE
NC score	0.054165 (rank : 1305)	θ value	θ > 10 (rank : 1272)
Query Neighborhood Hits	1044	Target Neighborhood Hits	415	Shared Neighborhood Hits	73
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

TACC1_HUMAN
NC score	0.054116 (rank : 1306)	θ value	θ > 10 (rank : 1396)
Query Neighborhood Hits	1044	Target Neighborhood Hits	597	Shared Neighborhood Hits	178
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

RPGR1_HUMAN
NC score	0.054077 (rank : 1307)	θ value	θ > 10 (rank : 1346)
Query Neighborhood Hits	1044	Target Neighborhood Hits	578	Shared Neighborhood Hits	158
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

CDC37_HUMAN
NC score	0.054010 (rank : 1308)	θ value	θ > 10 (rank : 1100)
Query Neighborhood Hits	1044	Target Neighborhood Hits	506	Shared Neighborhood Hits	167
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CRK_HUMAN
NC score	0.053896 (rank : 1309)	θ value	θ > 10 (rank : 1135)
Query Neighborhood Hits	1044	Target Neighborhood Hits	308	Shared Neighborhood Hits	53
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

KIF4A_MOUSE
NC score	0.053851 (rank : 1310)	θ value	1.81305 (rank : 924)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1033	Shared Neighborhood Hits	218
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

LZTS1_MOUSE
NC score	0.053714 (rank : 1311)	θ value	θ > 10 (rank : 1242)
Query Neighborhood Hits	1044	Target Neighborhood Hits	540	Shared Neighborhood Hits	164
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

SNX23_HUMAN
NC score	0.053681 (rank : 1312)	θ value	0.21417 (rank : 840)
Query Neighborhood Hits	1044	Target Neighborhood Hits	944	Shared Neighborhood Hits	200
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

GRB14_HUMAN
NC score	0.053518 (rank : 1313)	θ value	θ > 10 (rank : 1186)
Query Neighborhood Hits	1044	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

MACF1_HUMAN
NC score	0.053492 (rank : 1314)	θ value	θ > 10 (rank : 1243)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1341	Shared Neighborhood Hits	224
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

SPAG5_HUMAN
NC score	0.053488 (rank : 1315)	θ value	θ > 10 (rank : 1375)
Query Neighborhood Hits	1044	Target Neighborhood Hits	625	Shared Neighborhood Hits	169
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

MMRN1_HUMAN
NC score	0.053418 (rank : 1316)	θ value	θ > 10 (rank : 1255)
Query Neighborhood Hits	1044	Target Neighborhood Hits	636	Shared Neighborhood Hits	144
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

TACC3_MOUSE
NC score	0.053403 (rank : 1317)	θ value	θ > 10 (rank : 1399)
Query Neighborhood Hits	1044	Target Neighborhood Hits	607	Shared Neighborhood Hits	169
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

KINH_MOUSE
NC score	0.053224 (rank : 1318)	θ value	3.0926 (rank : 948)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1082	Shared Neighborhood Hits	225
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

MYPC3_MOUSE
NC score	0.053223 (rank : 1319)	θ value	θ > 10 (rank : 1274)
Query Neighborhood Hits	1044	Target Neighborhood Hits	310	Shared Neighborhood Hits	56
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

TPM4_HUMAN
NC score	0.053198 (rank : 1320)	θ value	θ > 10 (rank : 1418)
Query Neighborhood Hits	1044	Target Neighborhood Hits	525	Shared Neighborhood Hits	147
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

CTGE6_HUMAN
NC score	0.053189 (rank : 1321)	θ value	θ > 10 (rank : 1140)
Query Neighborhood Hits	1044	Target Neighborhood Hits	650	Shared Neighborhood Hits	168
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

TACC2_MOUSE
NC score	0.053133 (rank : 1322)	θ value	θ > 10 (rank : 1398)
Query Neighborhood Hits	1044	Target Neighborhood Hits	774	Shared Neighborhood Hits	184
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TNNT2_HUMAN
NC score	0.052961 (rank : 1323)	θ value	θ > 10 (rank : 1413)
Query Neighborhood Hits	1044	Target Neighborhood Hits	433	Shared Neighborhood Hits	130
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

BRAP_HUMAN
NC score	0.052819 (rank : 1324)	θ value	0.62314 (rank : 870)
Query Neighborhood Hits	1044	Target Neighborhood Hits	560	Shared Neighborhood Hits	146
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

STMN1_HUMAN
NC score	0.052668 (rank : 1325)	θ value	θ > 10 (rank : 1389)
Query Neighborhood Hits	1044	Target Neighborhood Hits	554	Shared Neighborhood Hits	181
SwissProt Accessions	P16949	Gene names	STMN1, LAP18, OP18
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Protein Pr22).

P85A_MOUSE
NC score	0.052596 (rank : 1326)	θ value	θ > 10 (rank : 1296)
Query Neighborhood Hits	1044	Target Neighborhood Hits	435	Shared Neighborhood Hits	114
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CRK_MOUSE
NC score	0.052561 (rank : 1327)	θ value	θ > 10 (rank : 1136)
Query Neighborhood Hits	1044	Target Neighborhood Hits	314	Shared Neighborhood Hits	53
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ZRF1_MOUSE
NC score	0.052521 (rank : 1328)	θ value	θ > 10 (rank : 1454)
Query Neighborhood Hits	1044	Target Neighborhood Hits	414	Shared Neighborhood Hits	126
SwissProt Accessions	P54103	Gene names	Zrf1, Dnajc2
Domain Architecture
Description	Zuotin-related factor 1.

SPC24_HUMAN
NC score	0.052423 (rank : 1329)	θ value	θ > 10 (rank : 1377)
Query Neighborhood Hits	1044	Target Neighborhood Hits	324	Shared Neighborhood Hits	125
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

SYNE2_HUMAN
NC score	0.052300 (rank : 1330)	θ value	θ > 10 (rank : 1394)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1323	Shared Neighborhood Hits	226
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

MYOM2_HUMAN
NC score	0.052217 (rank : 1331)	θ value	θ > 10 (rank : 1273)
Query Neighborhood Hits	1044	Target Neighborhood Hits	341	Shared Neighborhood Hits	61
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MACF1_MOUSE
NC score	0.052140 (rank : 1332)	θ value	θ > 10 (rank : 1244)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1313	Shared Neighborhood Hits	229
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

K0586_HUMAN
NC score	0.052065 (rank : 1333)	θ value	θ > 10 (rank : 1224)
Query Neighborhood Hits	1044	Target Neighborhood Hits	311	Shared Neighborhood Hits	104
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

VDP_HUMAN
NC score	0.051910 (rank : 1334)	θ value	θ > 10 (rank : 1443)
Query Neighborhood Hits	1044	Target Neighborhood Hits	645	Shared Neighborhood Hits	167
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

MYO7A_MOUSE
NC score	0.051844 (rank : 1335)	θ value	θ > 10 (rank : 1268)
Query Neighborhood Hits	1044	Target Neighborhood Hits	235	Shared Neighborhood Hits	76
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

STMN1_MOUSE
NC score	0.051804 (rank : 1336)	θ value	θ > 10 (rank : 1390)
Query Neighborhood Hits	1044	Target Neighborhood Hits	560	Shared Neighborhood Hits	182
SwissProt Accessions	P54227	Gene names	Stmn1, Lag, Lap18, Pr22
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Pr22 protein) (Leukemia-associated gene protein).

CU013_HUMAN
NC score	0.051741 (rank : 1337)	θ value	θ > 10 (rank : 1141)
Query Neighborhood Hits	1044	Target Neighborhood Hits	405	Shared Neighborhood Hits	135
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

PLVAP_HUMAN
NC score	0.051719 (rank : 1338)	θ value	θ > 10 (rank : 1317)
Query Neighborhood Hits	1044	Target Neighborhood Hits	397	Shared Neighborhood Hits	148
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

NPHP1_HUMAN
NC score	0.051670 (rank : 1339)	θ value	θ > 10 (rank : 1284)
Query Neighborhood Hits	1044	Target Neighborhood Hits	288	Shared Neighborhood Hits	77
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

SKIL_HUMAN
NC score	0.051448 (rank : 1340)	θ value	0.813845 (rank : 888)
Query Neighborhood Hits	1044	Target Neighborhood Hits	460	Shared Neighborhood Hits	137
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

CAR10_HUMAN
NC score	0.051395 (rank : 1341)	θ value	θ > 10 (rank : 1076)
Query Neighborhood Hits	1044	Target Neighborhood Hits	569	Shared Neighborhood Hits	181
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CENPH_HUMAN
NC score	0.051284 (rank : 1342)	θ value	θ > 10 (rank : 1103)
Query Neighborhood Hits	1044	Target Neighborhood Hits	335	Shared Neighborhood Hits	138
SwissProt Accessions	Q9H3R5	Gene names	CENPH, ICEN35
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H) (Interphase centromere complex protein 35).

MYO7A_HUMAN
NC score	0.051148 (rank : 1343)	θ value	θ > 10 (rank : 1267)
Query Neighborhood Hits	1044	Target Neighborhood Hits	209	Shared Neighborhood Hits	68
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

NEO1_MOUSE
NC score	0.050979 (rank : 1344)	θ value	θ > 10 (rank : 1282)
Query Neighborhood Hits	1044	Target Neighborhood Hits	523	Shared Neighborhood Hits	75
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

PRC1_HUMAN
NC score	0.050516 (rank : 1345)	θ value	θ > 10 (rank : 1321)
Query Neighborhood Hits	1044	Target Neighborhood Hits	328	Shared Neighborhood Hits	132
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

DGKB_HUMAN
NC score	0.050490 (rank : 1346)	θ value	θ > 10 (rank : 1153)
Query Neighborhood Hits	1044	Target Neighborhood Hits	238	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

MYO15_MOUSE
NC score	0.050481 (rank : 1347)	θ value	θ > 10 (rank : 1259)
Query Neighborhood Hits	1044	Target Neighborhood Hits	467	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NEO1_HUMAN
NC score	0.050449 (rank : 1348)	θ value	θ > 10 (rank : 1281)
Query Neighborhood Hits	1044	Target Neighborhood Hits	530	Shared Neighborhood Hits	72
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

LZTS1_HUMAN
NC score	0.050374 (rank : 1349)	θ value	θ > 10 (rank : 1241)
Query Neighborhood Hits	1044	Target Neighborhood Hits	532	Shared Neighborhood Hits	152
SwissProt Accessions	Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2	Gene names	LZTS1, FEZ1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

CHCH3_MOUSE
NC score	0.050353 (rank : 1350)	θ value	θ > 10 (rank : 1115)
Query Neighborhood Hits	1044	Target Neighborhood Hits	249	Shared Neighborhood Hits	108
SwissProt Accessions	Q9CRB9	Gene names	Chchd3
Domain Architecture	No domain graphic available
Description	Coiled-coil-helix-coiled-coil-helix domain-containing protein 3.

LIPA3_HUMAN
NC score	0.050211 (rank : 1351)	θ value	θ > 10 (rank : 1233)
Query Neighborhood Hits	1044	Target Neighborhood Hits	828	Shared Neighborhood Hits	196
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

MFAP1_HUMAN
NC score	0.050098 (rank : 1352)	θ value	θ > 10 (rank : 1252)
Query Neighborhood Hits	1044	Target Neighborhood Hits	321	Shared Neighborhood Hits	113
SwissProt Accessions	P55081	Gene names	MFAP1
Domain Architecture
Description	Microfibrillar-associated protein 1.

TACC3_HUMAN
NC score	0.050082 (rank : 1353)	θ value	8.99809 (rank : 1042)
Query Neighborhood Hits	1044	Target Neighborhood Hits	779	Shared Neighborhood Hits	175
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

NDEL1_HUMAN
NC score	0.049115 (rank : 1354)	θ value	3.0926 (rank : 950)
Query Neighborhood Hits	1044	Target Neighborhood Hits	415	Shared Neighborhood Hits	139
SwissProt Accessions	Q9GZM8, Q86T80, Q8TAR7, Q9UH50	Gene names	NDEL1, EOPA, MITAP1, NUDEL
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin- associated protein 1).

NDEL1_MOUSE
NC score	0.048902 (rank : 1355)	θ value	3.0926 (rank : 951)
Query Neighborhood Hits	1044	Target Neighborhood Hits	420	Shared Neighborhood Hits	141
SwissProt Accessions	Q9ERR1, Q9D0Q4, Q9EPT6	Gene names	Ndel1, Nudel
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Protein mNudE-like) (mNudE-L).

MOES_HUMAN
NC score	0.048361 (rank : 1356)	θ value	0.125558 (rank : 820)
Query Neighborhood Hits	1044	Target Neighborhood Hits	892	Shared Neighborhood Hits	193
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

LRSM1_HUMAN
NC score	0.046006 (rank : 1357)	θ value	6.88961 (rank : 1000)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1078	Shared Neighborhood Hits	213
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

ANR12_HUMAN
NC score	0.045904 (rank : 1358)	θ value	2.36792 (rank : 931)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1081	Shared Neighborhood Hits	177
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

SAFB2_MOUSE
NC score	0.045185 (rank : 1359)	θ value	3.0926 (rank : 955)
Query Neighborhood Hits	1044	Target Neighborhood Hits	581	Shared Neighborhood Hits	142
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

K0494_HUMAN
NC score	0.044537 (rank : 1360)	θ value	1.38821 (rank : 912)
Query Neighborhood Hits	1044	Target Neighborhood Hits	230	Shared Neighborhood Hits	92
SwissProt Accessions	O75071	Gene names	KIAA0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

PHLB1_MOUSE
NC score	0.044441 (rank : 1361)	θ value	1.81305 (rank : 927)
Query Neighborhood Hits	1044	Target Neighborhood Hits	678	Shared Neighborhood Hits	151
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

AMOL1_MOUSE
NC score	0.043442 (rank : 1362)	θ value	2.36792 (rank : 930)
Query Neighborhood Hits	1044	Target Neighborhood Hits	445	Shared Neighborhood Hits	140
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

UBXD2_MOUSE
NC score	0.042917 (rank : 1363)	θ value	0.0736092 (rank : 810)
Query Neighborhood Hits	1044	Target Neighborhood Hits	183	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VCH8, Q8BW17	Gene names	Ubxd2, Ubxdc1
Domain Architecture
Description	UBX domain-containing protein 2.

EZRI_MOUSE
NC score	0.042030 (rank : 1364)	θ value	8.99809 (rank : 1030)
Query Neighborhood Hits	1044	Target Neighborhood Hits	693	Shared Neighborhood Hits	184
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

LRC27_HUMAN
NC score	0.041001 (rank : 1365)	θ value	1.06291 (rank : 901)
Query Neighborhood Hits	1044	Target Neighborhood Hits	710	Shared Neighborhood Hits	160
SwissProt Accessions	Q9C0I9, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21	Gene names	LRRC27, KIAA1674
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

SFR12_MOUSE
NC score	0.040628 (rank : 1366)	θ value	0.125558 (rank : 822)
Query Neighborhood Hits	1044	Target Neighborhood Hits	486	Shared Neighborhood Hits	92
SwissProt Accessions	Q8BZX4, Q8BLM8, Q8BWK7, Q8BYK0, Q8BYZ4	Gene names	Sfrs12, Srrp86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86).

RADI_MOUSE
NC score	0.040447 (rank : 1367)	θ value	6.88961 (rank : 1004)
Query Neighborhood Hits	1044	Target Neighborhood Hits	773	Shared Neighborhood Hits	171
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

BAZ2B_HUMAN
NC score	0.039317 (rank : 1368)	θ value	5.27518 (rank : 975)
Query Neighborhood Hits	1044	Target Neighborhood Hits	803	Shared Neighborhood Hits	165
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

RADI_HUMAN
NC score	0.038994 (rank : 1369)	θ value	3.0926 (rank : 953)
Query Neighborhood Hits	1044	Target Neighborhood Hits	741	Shared Neighborhood Hits	175
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

WDR60_MOUSE
NC score	0.037847 (rank : 1370)	θ value	8.99809 (rank : 1043)
Query Neighborhood Hits	1044	Target Neighborhood Hits	344	Shared Neighborhood Hits	92
SwissProt Accessions	Q8C761, Q3UNM4	Gene names	Wdr60
Domain Architecture	No domain graphic available
Description	WD repeat protein 60.

SRRM2_MOUSE
NC score	0.037157 (rank : 1371)	θ value	6.88961 (rank : 1008)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1470	Shared Neighborhood Hits	129
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

K0494_MOUSE
NC score	0.035747 (rank : 1372)	θ value	6.88961 (rank : 998)
Query Neighborhood Hits	1044	Target Neighborhood Hits	241	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BGQ6, Q3TQN6, Q8BJV7, Q8C0R1	Gene names	Kiaa0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

ENAH_MOUSE
NC score	0.035411 (rank : 1373)	θ value	8.99809 (rank : 1029)
Query Neighborhood Hits	1044	Target Neighborhood Hits	919	Shared Neighborhood Hits	156
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

BRAP_MOUSE
NC score	0.034678 (rank : 1374)	θ value	6.88961 (rank : 994)
Query Neighborhood Hits	1044	Target Neighborhood Hits	409	Shared Neighborhood Hits	111
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

KIF3C_MOUSE
NC score	0.034336 (rank : 1375)	θ value	0.813845 (rank : 885)
Query Neighborhood Hits	1044	Target Neighborhood Hits	468	Shared Neighborhood Hits	145
SwissProt Accessions	O35066, O35229	Gene names	Kif3c
Domain Architecture
Description	Kinesin-like protein KIF3C.

POT15_HUMAN
NC score	0.034275 (rank : 1376)	θ value	8.99809 (rank : 1035)
Query Neighborhood Hits	1044	Target Neighborhood Hits	893	Shared Neighborhood Hits	195
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

KIF3A_MOUSE
NC score	0.033787 (rank : 1377)	θ value	1.81305 (rank : 923)
Query Neighborhood Hits	1044	Target Neighborhood Hits	715	Shared Neighborhood Hits	187
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3A_HUMAN
NC score	0.032888 (rank : 1378)	θ value	1.38821 (rank : 913)
Query Neighborhood Hits	1044	Target Neighborhood Hits	704	Shared Neighborhood Hits	178
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF3C_HUMAN
NC score	0.032586 (rank : 1379)	θ value	1.06291 (rank : 898)
Query Neighborhood Hits	1044	Target Neighborhood Hits	478	Shared Neighborhood Hits	143
SwissProt Accessions	O14782, O43544	Gene names	KIF3C
Domain Architecture
Description	Kinesin-like protein KIF3C.

SDS3_HUMAN
NC score	0.031880 (rank : 1380)	θ value	5.27518 (rank : 988)
Query Neighborhood Hits	1044	Target Neighborhood Hits	257	Shared Neighborhood Hits	97
SwissProt Accessions	Q9H7L9, Q8N6H0, Q9H8D2	Gene names	SUDS3, SDS3
Domain Architecture	No domain graphic available
Description	Sin3 histone deacetylase corepressor complex component SDS3 (Suppressor of defective silencing 3 protein homolog).

HDAC9_MOUSE
NC score	0.030818 (rank : 1381)	θ value	0.279714 (rank : 847)
Query Neighborhood Hits	1044	Target Neighborhood Hits	186	Shared Neighborhood Hits	75
SwissProt Accessions	Q99N13, Q9EPT2	Gene names	Hdac9, Hdac7b, Hdrp, Mitr
Domain Architecture	No domain graphic available
Description	Histone deacetylase 9 (HD9) (HD7B) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR).

SAFB1_HUMAN
NC score	0.030405 (rank : 1382)	θ value	0.813845 (rank : 887)
Query Neighborhood Hits	1044	Target Neighborhood Hits	493	Shared Neighborhood Hits	100
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

RBP1_HUMAN
NC score	0.030299 (rank : 1383)	θ value	0.21417 (rank : 838)
Query Neighborhood Hits	1044	Target Neighborhood Hits	521	Shared Neighborhood Hits	132
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

SNP25_HUMAN
NC score	0.023887 (rank : 1384)	θ value	8.99809 (rank : 1040)
Query Neighborhood Hits	1044	Target Neighborhood Hits	96	Shared Neighborhood Hits	49
SwissProt Accessions	P60880, P13795, P36974, P70557, P70558, Q8IXK3, Q96FM2, Q9BR45	Gene names	SNAP25, SNAP
Domain Architecture
Description	Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) (Super protein) (SUP).

SNP25_MOUSE
NC score	0.023887 (rank : 1385)	θ value	8.99809 (rank : 1041)
Query Neighborhood Hits	1044	Target Neighborhood Hits	96	Shared Neighborhood Hits	49
SwissProt Accessions	P60879, P13795, P36974, P70557, P70558, Q8IXK3, Q96FM2, Q9BR45	Gene names	Snap25, Snap
Domain Architecture
Description	Synaptosomal-associated protein 25 (SNAP-25) (Synaptosomal-associated 25 kDa protein) (Super protein) (SUP).

CB010_HUMAN
NC score	0.023561 (rank : 1386)	θ value	0.813845 (rank : 881)
Query Neighborhood Hits	1044	Target Neighborhood Hits	130	Shared Neighborhood Hits	30
SwissProt Accessions	Q7Z570, Q6ZN26	Gene names	C2orf10
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf10.

NFL_MOUSE
NC score	0.023510 (rank : 1387)	θ value	0.0330416 (rank : 791)
Query Neighborhood Hits	1044	Target Neighborhood Hits	695	Shared Neighborhood Hits	163
SwissProt Accessions	P08551, Q8K0Z0	Gene names	Nefl, Nf68, Nfl
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

NFL_HUMAN
NC score	0.022888 (rank : 1388)	θ value	0.125558 (rank : 821)
Query Neighborhood Hits	1044	Target Neighborhood Hits	666	Shared Neighborhood Hits	158
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

SFR16_MOUSE
NC score	0.022624 (rank : 1389)	θ value	8.99809 (rank : 1039)
Query Neighborhood Hits	1044	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	Q8CFC7, Q8CFC8, Q9Z2N3	Gene names	Sfrs16, Clasp, Swap2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2) (Clk4-associating SR-related protein).

HDAC5_HUMAN
NC score	0.021306 (rank : 1390)	θ value	6.88961 (rank : 996)
Query Neighborhood Hits	1044	Target Neighborhood Hits	353	Shared Neighborhood Hits	113
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

CCD43_MOUSE
NC score	0.020977 (rank : 1391)	θ value	1.06291 (rank : 894)
Query Neighborhood Hits	1044	Target Neighborhood Hits	63	Shared Neighborhood Hits	32
SwissProt Accessions	Q9CR29, Q6PDT2	Gene names	Ccdc43, D11Ertd707e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 43.

STABP_MOUSE
NC score	0.020538 (rank : 1392)	θ value	1.81305 (rank : 928)
Query Neighborhood Hits	1044	Target Neighborhood Hits	191	Shared Neighborhood Hits	64
SwissProt Accessions	Q9CQ26, Q3UTI9	Gene names	Stambp, Amsh
Domain Architecture	No domain graphic available
Description	STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3 domain of STAM).

SMCA4_HUMAN
NC score	0.019309 (rank : 1393)	θ value	0.21417 (rank : 839)
Query Neighborhood Hits	1044	Target Neighborhood Hits	597	Shared Neighborhood Hits	107
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

SFR16_HUMAN
NC score	0.019141 (rank : 1394)	θ value	8.99809 (rank : 1038)
Query Neighborhood Hits	1044	Target Neighborhood Hits	178	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N2M8, O96026, Q6UW71, Q96DX2	Gene names	SFRS16, SWAP2
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 16 (Suppressor of white-apricot homolog 2).

ZCPW1_MOUSE
NC score	0.018811 (rank : 1395)	θ value	1.38821 (rank : 918)
Query Neighborhood Hits	1044	Target Neighborhood Hits	307	Shared Neighborhood Hits	49
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

MLL3_HUMAN
NC score	0.018016 (rank : 1396)	θ value	0.47712 (rank : 865)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1644	Shared Neighborhood Hits	143
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

TBCD4_MOUSE
NC score	0.017282 (rank : 1397)	θ value	5.27518 (rank : 991)
Query Neighborhood Hits	1044	Target Neighborhood Hits	276	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BYJ6, Q5DU23, Q66JU2, Q6P2M2, Q8BMH6, Q8BXM2	Gene names	Tbc1d4, Kiaa0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

ASZ1_HUMAN
NC score	0.016748 (rank : 1398)	θ value	5.27518 (rank : 973)
Query Neighborhood Hits	1044	Target Neighborhood Hits	341	Shared Neighborhood Hits	45
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

MLL3_MOUSE
NC score	0.016523 (rank : 1399)	θ value	0.47712 (rank : 866)
Query Neighborhood Hits	1044	Target Neighborhood Hits	1399	Shared Neighborhood Hits	122
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

ZFAN6_MOUSE
NC score	0.016098 (rank : 1400)	θ value	1.81305 (rank : 929)
Query Neighborhood Hits	1044	Target Neighborhood Hits	92	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DCH6, Q9ER79	Gene names	Zfand6, Awp1, Za20d3
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 6 (Zinc finger A20 domain-containing protein 3) (Associated with PRK1 protein).

HDAC5_MOUSE
NC score	0.016072 (rank : 1401)	θ value	5.27518 (rank : 980)
Query Neighborhood Hits	1044	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

NOC2L_HUMAN
NC score	0.015243 (rank : 1402)	θ value	4.03905 (rank : 966)
Query Neighborhood Hits	1044	Target Neighborhood Hits	49	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y3T9, Q5SVA3, Q9BTN6	Gene names	NOC2L
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

NOC2L_MOUSE
NC score	0.014693 (rank : 1403)	θ value	5.27518 (rank : 985)
Query Neighborhood Hits	1044	Target Neighborhood Hits	56	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WV70, Q8VE16	Gene names	Noc2l
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

RN168_MOUSE
NC score	0.014480 (rank : 1404)	θ value	4.03905 (rank : 967)
Query Neighborhood Hits	1044	Target Neighborhood Hits	440	Shared Neighborhood Hits	78
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

HDAC9_HUMAN
NC score	0.014433 (rank : 1405)	θ value	0.47712 (rank : 863)
Query Neighborhood Hits	1044	Target Neighborhood Hits	201	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UKV0, O94845, O95028	Gene names	HDAC9, HDAC7, HDAC7B, KIAA0744
Domain Architecture
Description	Histone deacetylase 9 (HD9) (HD7B) (HD7).

ASZ1_MOUSE
NC score	0.014332 (rank : 1406)	θ value	5.27518 (rank : 974)
Query Neighborhood Hits	1044	Target Neighborhood Hits	319	Shared Neighborhood Hits	34
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

TRIP4_HUMAN
NC score	0.014185 (rank : 1407)	θ value	0.47712 (rank : 869)
Query Neighborhood Hits	1044	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q15650, Q96ED7, Q9UKH0	Gene names	TRIP4
Domain Architecture
Description	Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TRIP-4).

ZC3H5_MOUSE
NC score	0.014012 (rank : 1408)	θ value	0.62314 (rank : 879)
Query Neighborhood Hits	1044	Target Neighborhood Hits	136	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

ZC3H5_HUMAN
NC score	0.013717 (rank : 1409)	θ value	3.0926 (rank : 957)
Query Neighborhood Hits	1044	Target Neighborhood Hits	134	Shared Neighborhood Hits	29
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

ADCK1_HUMAN
NC score	0.013060 (rank : 1410)	θ value	8.99809 (rank : 1015)
Query Neighborhood Hits	1044	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	Q86TW2, Q6PD65	Gene names	ADCK1
Domain Architecture	No domain graphic available
Description	Uncharacterized aarF domain-containing protein kinase 1 precursor (EC 2.7.-.-).

GCYB2_HUMAN
NC score	0.012848 (rank : 1411)	θ value	1.38821 (rank : 909)
Query Neighborhood Hits	1044	Target Neighborhood Hits	61	Shared Neighborhood Hits	17
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

IGBP1_MOUSE
NC score	0.012056 (rank : 1412)	θ value	0.279714 (rank : 848)
Query Neighborhood Hits	1044	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	Q61249	Gene names	Igbp1, Pc52
Domain Architecture
Description	Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (Alpha4 phosphoprotein) (Lymphocyte signal transduction molecule alpha 4) (p52).

BRD3_MOUSE
NC score	0.011799 (rank : 1413)	θ value	4.03905 (rank : 960)
Query Neighborhood Hits	1044	Target Neighborhood Hits	402	Shared Neighborhood Hits	96
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

CJ078_MOUSE
NC score	0.011568 (rank : 1414)	θ value	0.21417 (rank : 834)
Query Neighborhood Hits	1044	Target Neighborhood Hits	559	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

DDX23_HUMAN
NC score	0.011474 (rank : 1415)	θ value	3.0926 (rank : 944)
Query Neighborhood Hits	1044	Target Neighborhood Hits	486	Shared Neighborhood Hits	110
SwissProt Accessions	Q9BUQ8, O43188	Gene names	DDX23
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX23 (EC 3.6.1.-) (DEAD box protein 23) (100 kDa U5 snRNP-specific protein) (U5-100kD) (PRP28 homolog).

GGA1_MOUSE
NC score	0.009796 (rank : 1416)	θ value	1.81305 (rank : 921)
Query Neighborhood Hits	1044	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

IRS2_HUMAN
NC score	0.009378 (rank : 1417)	θ value	4.03905 (rank : 965)
Query Neighborhood Hits	1044	Target Neighborhood Hits	262	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

IF4G3_MOUSE
NC score	0.008282 (rank : 1418)	θ value	8.99809 (rank : 1032)
Query Neighborhood Hits	1044	Target Neighborhood Hits	279	Shared Neighborhood Hits	67
SwissProt Accessions	Q80XI3, Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0	Gene names	Eif4g3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

NC6IP_HUMAN
NC score	0.008139 (rank : 1419)	θ value	5.27518 (rank : 984)
Query Neighborhood Hits	1044	Target Neighborhood Hits	116	Shared Neighborhood Hits	22
SwissProt Accessions	Q96RS0, Q5GH23, Q8TDG9, Q96QU3, Q9H5V3	Gene names	NCOA6IP, PIMT
Domain Architecture	No domain graphic available
Description	Putative RNA methyltransferase NCOA6IP (EC 2.1.1.-) (Nuclear receptor coactivator 6-interacting protein) (PRIP-interacting protein with methyltransferase motif) (PIPMT) (PIMT) (CLL-associated antigen KW-2) (Hepatocellular carcinoma-associated antigen 137) (HCA137).

ZFAN6_HUMAN
NC score	0.008120 (rank : 1420)	θ value	3.0926 (rank : 958)
Query Neighborhood Hits	1044	Target Neighborhood Hits	32	Shared Neighborhood Hits	6
SwissProt Accessions	Q6FIF0, O95792, Q9BQF7, Q9GZY3	Gene names	ZFAND6, AWP1, ZA20D3
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 6 (Zinc finger A20 domain-containing protein 3) (Associated with PRK1 protein).

TBP_MOUSE
NC score	0.007564 (rank : 1421)	θ value	2.36792 (rank : 940)
Query Neighborhood Hits	1044	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	P29037, O09169, Q80UL8, Q8C3S1	Gene names	Tbp, Tfiid
Domain Architecture
Description	TATA-box-binding protein (TATA-box factor) (TATA-binding factor) (TATA sequence-binding protein) (Transcription initiation factor TFIID TBP subunit).

IF4B_HUMAN
NC score	0.007192 (rank : 1422)	θ value	6.88961 (rank : 997)
Query Neighborhood Hits	1044	Target Neighborhood Hits	417	Shared Neighborhood Hits	32
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

TTC16_HUMAN
NC score	0.006845 (rank : 1423)	θ value	4.03905 (rank : 969)
Query Neighborhood Hits	1044	Target Neighborhood Hits	417	Shared Neighborhood Hits	39
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

F126A_HUMAN
NC score	0.006334 (rank : 1424)	θ value	4.03905 (rank : 963)
Query Neighborhood Hits	1044	Target Neighborhood Hits	14	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYI3, Q6N010, Q75MR4, Q7LDZ4, Q96MX1, Q96NQ6	Gene names	FAM126A, DRCTNNB1A
Domain Architecture	No domain graphic available
Description	Protein FAM126A (Down-regulated by CTNNB1 protein A).

SOX13_MOUSE
NC score	0.005582 (rank : 1425)	θ value	1.06291 (rank : 903)
Query Neighborhood Hits	1044	Target Neighborhood Hits	495	Shared Neighborhood Hits	47
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

CNKR2_HUMAN
NC score	0.005408 (rank : 1426)	θ value	1.06291 (rank : 895)
Query Neighborhood Hits	1044	Target Neighborhood Hits	197	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
NC score	0.005395 (rank : 1427)	θ value	1.06291 (rank : 896)
Query Neighborhood Hits	1044	Target Neighborhood Hits	197	Shared Neighborhood Hits	20
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

ASPC1_HUMAN
NC score	0.005169 (rank : 1428)	θ value	5.27518 (rank : 972)
Query Neighborhood Hits	1044	Target Neighborhood Hits	46	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BZE9, Q7Z6N7, Q8WV59, Q96LS5, Q96M40	Gene names	ASPSCR1, ASPL, RCC17, TUG
Domain Architecture	No domain graphic available
Description	Tether containing UBX domain for GLUT4 (Alveolar soft part sarcoma chromosome region candidate 1) (Alveolar soft part sarcoma locus) (Renal papillary cell carcinoma protein 17).

CAPS2_HUMAN
NC score	0.005152 (rank : 1429)	θ value	6.88961 (rank : 995)
Query Neighborhood Hits	1044	Target Neighborhood Hits	81	Shared Neighborhood Hits	26
SwissProt Accessions	Q86UW7, Q658Q2, Q7Z5T7, Q8IZW9, Q8N7M4, Q9H6P4, Q9HCI1, Q9NWK8	Gene names	CADPS2, CAPS2, KIAA1591
Domain Architecture	No domain graphic available
Description	Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2).

UBP2L_MOUSE
NC score	0.004839 (rank : 1430)	θ value	4.03905 (rank : 970)
Query Neighborhood Hits	1044	Target Neighborhood Hits	173	Shared Neighborhood Hits	10
SwissProt Accessions	Q80X50, Q8BIT6, Q8BIW4, Q8BJ01, Q8CIG7, Q8K102, Q9CRT6	Gene names	Ubap2l
Domain Architecture	No domain graphic available
Description	Ubiquitin-associated protein 2-like.

NPTX2_MOUSE
NC score	0.003988 (rank : 1431)	θ value	2.36792 (rank : 937)
Query Neighborhood Hits	1044	Target Neighborhood Hits	79	Shared Neighborhood Hits	23
SwissProt Accessions	O70340	Gene names	Nptx2
Domain Architecture
Description	Neuronal pentraxin-2 precursor (NP2) (Neuronal pentraxin II) (NP-II).

CS007_MOUSE
NC score	0.003173 (rank : 1432)	θ value	8.99809 (rank : 1024)
Query Neighborhood Hits	1044	Target Neighborhood Hits	464	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

BOREA_HUMAN
NC score	0.002144 (rank : 1433)	θ value	8.99809 (rank : 1017)
Query Neighborhood Hits	1044	Target Neighborhood Hits	20	Shared Neighborhood Hits	7
SwissProt Accessions	Q53HL2, Q53HN1, Q96AM3, Q9NVW5	Gene names	CDCA8, PESCRG3
Domain Architecture	No domain graphic available
Description	Borealin (Dasra-B) (hDasra-B) (Cell division cycle-associated protein 8) (Pluripotent embryonic stem cell-related gene 3 protein).

FGFP3_HUMAN
NC score	0.001587 (rank : 1434)	θ value	8.99809 (rank : 1031)
Query Neighborhood Hits	1044	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TAT2, Q8NBN0	Gene names	FGFBP3, C10orf13
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor-binding protein 3 precursor (FGF-binding protein 3) (FGF-BP3) (FGFBP-3).

WWTR1_HUMAN
NC score	0.001325 (rank : 1435)	θ value	8.99809 (rank : 1044)
Query Neighborhood Hits	1044	Target Neighborhood Hits	76	Shared Neighborhood Hits	7
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

SORC2_HUMAN
NC score	0.001118 (rank : 1436)	θ value	6.88961 (rank : 1007)
Query Neighborhood Hits	1044	Target Neighborhood Hits	66	Shared Neighborhood Hits	8
SwissProt Accessions	Q96PQ0, Q9P2L7	Gene names	SORCS2, KIAA1329
Domain Architecture
Description	VPS10 domain-containing receptor SorCS2 precursor.

CHD1_MOUSE
NC score	0.001076 (rank : 1437)	θ value	0.62314 (rank : 872)
Query Neighborhood Hits	1044	Target Neighborhood Hits	266	Shared Neighborhood Hits	28
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

DOCK3_HUMAN
NC score	0.000999 (rank : 1438)	θ value	8.99809 (rank : 1026)
Query Neighborhood Hits	1044	Target Neighborhood Hits	87	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

B3A3_HUMAN
NC score	0.000972 (rank : 1439)	θ value	0.47712 (rank : 859)
Query Neighborhood Hits	1044	Target Neighborhood Hits	119	Shared Neighborhood Hits	12
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

DOCK3_MOUSE
NC score	0.000962 (rank : 1440)	θ value	8.99809 (rank : 1027)
Query Neighborhood Hits	1044	Target Neighborhood Hits	93	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

GAGD4_HUMAN
NC score	0.000682 (rank : 1441)	θ value	3.0926 (rank : 947)
Query Neighborhood Hits	1044	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WTP9, Q5JS82, Q8WYS9	Gene names	XAGE3, GAGED4, PLAC6
Domain Architecture
Description	G antigen family D member 4 (Placenta-specific gene 6 protein) (Protein XAGE-3).

ZN541_HUMAN
NC score	0.000106 (rank : 1442)	θ value	6.88961 (rank : 1013)
Query Neighborhood Hits	1044	Target Neighborhood Hits	203	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H0D2, Q8NDK8	Gene names	ZNF541
Domain Architecture	No domain graphic available
Description	Zinc finger protein 541.

SCAM3_MOUSE
NC score	-0.000352 (rank : 1443)	θ value	8.99809 (rank : 1037)
Query Neighborhood Hits	1044	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	O35609, Q99M48, Q9ERM9	Gene names	Scamp3
Domain Architecture
Description	Secretory carrier-associated membrane protein 3 (Secretory carrier membrane protein 3).

HNF1B_MOUSE
NC score	-0.000513 (rank : 1444)	θ value	5.27518 (rank : 982)
Query Neighborhood Hits	1044	Target Neighborhood Hits	78	Shared Neighborhood Hits	2
SwissProt Accessions	P27889, Q8R162, Q9CS26, Q9R1W1, Q9R1W2, Q9WTL5, Q9WTL6	Gene names	Tcf2, Hnf-1b, Hnf1b
Domain Architecture
Description	Hepatocyte nuclear factor 1-beta (HNF-1beta) (HNF-1B) (Variant hepatic nuclear factor 1) (VHNF1) (Homeoprotein LFB3).

AP3B1_HUMAN
NC score	-0.001141 (rank : 1445)	θ value	6.88961 (rank : 993)
Query Neighborhood Hits	1044	Target Neighborhood Hits	283	Shared Neighborhood Hits	20
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

ZIM10_HUMAN
NC score	-0.001158 (rank : 1446)	θ value	6.88961 (rank : 1011)
Query Neighborhood Hits	1044	Target Neighborhood Hits	577	Shared Neighborhood Hits	29
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

BTAF1_HUMAN
NC score	-0.001213 (rank : 1447)	θ value	8.99809 (rank : 1019)
Query Neighborhood Hits	1044	Target Neighborhood Hits	97	Shared Neighborhood Hits	6
SwissProt Accessions	O14981, O43578	Gene names	BTAF1, TAF172
Domain Architecture
Description	TATA-binding protein-associated factor 172 (EC 3.6.1.-) (ATP-dependent helicase BTAF1) (TBP-associated factor 172) (TAF-172) (TAF(II)170) (B- TFIID transcription factor-associated 170 kDa subunit).

DHX37_HUMAN
NC score	-0.001300 (rank : 1448)	θ value	8.99809 (rank : 1025)
Query Neighborhood Hits	1044	Target Neighborhood Hits	133	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IY37, Q9BUI7, Q9P211	Gene names	DHX37, DDX37, KIAA1517
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.1.-) (DEAH box protein 37).

SART3_HUMAN
NC score	-0.001454 (rank : 1449)	θ value	4.03905 (rank : 968)
Query Neighborhood Hits	1044	Target Neighborhood Hits	301	Shared Neighborhood Hits	36
SwissProt Accessions	Q15020, Q58F06, Q8IUS1, Q96J95	Gene names	SART3, KIAA0156, TIP110
Domain Architecture	No domain graphic available
Description	Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (hSART-3) (Tat-interacting protein of 110 kDa) (Tip110).

PSA_HUMAN
NC score	-0.002187 (rank : 1450)	θ value	8.99809 (rank : 1036)
Query Neighborhood Hits	1044	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P55786, Q6P145, Q9NP16, Q9UEM2	Gene names	NPEPPS, PSA
Domain Architecture
Description	Puromycin-sensitive aminopeptidase (EC 3.4.11.-) (PSA).

ZIM10_MOUSE
NC score	-0.002979 (rank : 1451)	θ value	6.88961 (rank : 1012)
Query Neighborhood Hits	1044	Target Neighborhood Hits	430	Shared Neighborhood Hits	19
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

UHRF1_HUMAN
NC score	-0.004415 (rank : 1452)	θ value	4.03905 (rank : 971)
Query Neighborhood Hits	1044	Target Neighborhood Hits	272	Shared Neighborhood Hits	12
SwissProt Accessions	Q96T88, Q8J022, Q9H6S6, Q9P115, Q9P1U7	Gene names	UHRF1, ICBP90, NP95, RNF106
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 1 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 1) (Inverted CCAAT box-binding protein of 90 kDa) (Transcription factor ICBP90) (Nuclear zinc finger protein Np95) (Nuclear protein 95) (HuNp95) (RING finger protein 106).

CP24A_MOUSE
NC score	-0.004710 (rank : 1453)	θ value	4.03905 (rank : 961)
Query Neighborhood Hits	1044	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q64441	Gene names	Cyp24a1, Cyp-24, Cyp24
Domain Architecture
Description	Cytochrome P450 24A1, mitochondrial precursor (EC 1.14.-.-) (P450- CC24) (Vitamin D(3) 24-hydroxylase) (1,25-dihydroxyvitamin D(3) 24- hydroxylase) (24-OHase).

TRI47_HUMAN
NC score	-0.009350 (rank : 1454)	θ value	6.88961 (rank : 1009)
Query Neighborhood Hits	1044	Target Neighborhood Hits	286	Shared Neighborhood Hits	9
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TMPSD_HUMAN
NC score	-0.011422 (rank : 1455)	θ value	5.27518 (rank : 992)
Query Neighborhood Hits	1044	Target Neighborhood Hits	333	Shared Neighborhood Hits	13
SwissProt Accessions	Q9BYE2, Q86YM4, Q96JY8, Q9BYE1	Gene names	TMPRSS13, MSP, TMPRSS11
Domain Architecture	No domain graphic available
Description	Transmembrane protease, serine 13 (EC 3.4.21.-) (Mosaic serine protease) (Membrane-type mosaic serine protease).