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Network neighborhood for query Sequence : DGKB_HUMAN

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DGKB_HUMAN
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DGKA_HUMAN
θ value	0 (rank : 1)	NC score	0.959154 (rank : 5)
Query Neighborhood Hits	238	Target Neighborhood Hits	151	Shared Neighborhood Hits	123
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

DGKA_MOUSE
θ value	0 (rank : 2)	NC score	0.960040 (rank : 4)
Query Neighborhood Hits	238	Target Neighborhood Hits	146	Shared Neighborhood Hits	124
SwissProt Accessions	O88673, Q922X2	Gene names	Dgka, Dagk1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

DGKB_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	238	Target Neighborhood Hits	238	Shared Neighborhood Hits	238
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKG_HUMAN
θ value	0 (rank : 4)	NC score	0.977427 (rank : 3)
Query Neighborhood Hits	238	Target Neighborhood Hits	171	Shared Neighborhood Hits	139
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

DGKG_MOUSE
θ value	0 (rank : 5)	NC score	0.979174 (rank : 2)
Query Neighborhood Hits	238	Target Neighborhood Hits	188	Shared Neighborhood Hits	144
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

DGKI_HUMAN
θ value	1.10959e-82 (rank : 6)	NC score	0.683806 (rank : 14)
Query Neighborhood Hits	238	Target Neighborhood Hits	609	Shared Neighborhood Hits	35
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

DGKZ_HUMAN
θ value	3.34088e-79 (rank : 7)	NC score	0.690012 (rank : 13)
Query Neighborhood Hits	238	Target Neighborhood Hits	551	Shared Neighborhood Hits	32
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKZ_MOUSE
θ value	2.82823e-78 (rank : 8)	NC score	0.693975 (rank : 12)
Query Neighborhood Hits	238	Target Neighborhood Hits	542	Shared Neighborhood Hits	33
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKE_HUMAN
θ value	1.5519e-76 (rank : 9)	NC score	0.838304 (rank : 7)
Query Neighborhood Hits	238	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	P52429, Q9UKQ3	Gene names	DGKE, DAGK5
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

DGKE_MOUSE
θ value	5.8972e-76 (rank : 10)	NC score	0.836264 (rank : 8)
Query Neighborhood Hits	238	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1C6	Gene names	Dgke
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

DGKQ_HUMAN
θ value	2.24614e-67 (rank : 11)	NC score	0.873193 (rank : 6)
Query Neighborhood Hits	238	Target Neighborhood Hits	131	Shared Neighborhood Hits	75
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

DGKD_HUMAN
θ value	3.71957e-54 (rank : 12)	NC score	0.779627 (rank : 9)
Query Neighborhood Hits	238	Target Neighborhood Hits	231	Shared Neighborhood Hits	68
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	3.1488e-53 (rank : 13)	NC score	0.774345 (rank : 10)
Query Neighborhood Hits	238	Target Neighborhood Hits	255	Shared Neighborhood Hits	70
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKK_HUMAN
θ value	4.86918e-46 (rank : 14)	NC score	0.696841 (rank : 11)
Query Neighborhood Hits	238	Target Neighborhood Hits	378	Shared Neighborhood Hits	38
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

KPCB_MOUSE
θ value	1.63604e-09 (rank : 15)	NC score	0.151604 (rank : 120)
Query Neighborhood Hits	238	Target Neighborhood Hits	1117	Shared Neighborhood Hits	80
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_HUMAN
θ value	2.13673e-09 (rank : 16)	NC score	0.151562 (rank : 121)
Query Neighborhood Hits	238	Target Neighborhood Hits	1121	Shared Neighborhood Hits	80
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCG_HUMAN
θ value	2.79066e-09 (rank : 17)	NC score	0.155924 (rank : 108)
Query Neighborhood Hits	238	Target Neighborhood Hits	1126	Shared Neighborhood Hits	85
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
θ value	2.79066e-09 (rank : 18)	NC score	0.155594 (rank : 109)
Query Neighborhood Hits	238	Target Neighborhood Hits	1123	Shared Neighborhood Hits	85
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCD_HUMAN
θ value	3.64472e-09 (rank : 19)	NC score	0.156788 (rank : 107)
Query Neighborhood Hits	238	Target Neighborhood Hits	900	Shared Neighborhood Hits	74
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	8.11959e-09 (rank : 20)	NC score	0.157004 (rank : 106)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	73
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

HPCL1_MOUSE
θ value	1.06045e-08 (rank : 21)	NC score	0.368408 (rank : 19)
Query Neighborhood Hits	238	Target Neighborhood Hits	149	Shared Neighborhood Hits	107
SwissProt Accessions	P62748, P35333	Gene names	Hpcal1
Domain Architecture	No domain graphic available
Description	Hippocalcin-like protein 1 (Visinin-like protein 3) (VILIP-3) (Neural visinin-like protein 3) (NVL-3) (NVP-3).

KPCA_HUMAN
θ value	1.06045e-08 (rank : 22)	NC score	0.146260 (rank : 128)
Query Neighborhood Hits	238	Target Neighborhood Hits	1070	Shared Neighborhood Hits	73
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	1.38499e-08 (rank : 23)	NC score	0.145883 (rank : 129)
Query Neighborhood Hits	238	Target Neighborhood Hits	1067	Shared Neighborhood Hits	73
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

GUC1A_HUMAN
θ value	2.36244e-08 (rank : 24)	NC score	0.379713 (rank : 16)
Query Neighborhood Hits	238	Target Neighborhood Hits	147	Shared Neighborhood Hits	114
SwissProt Accessions	P43080, Q9NU14	Gene names	GUCA1A, GCAP, GCAP1, GUCA1
Domain Architecture
Description	Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A).

HPCA_HUMAN
θ value	2.36244e-08 (rank : 25)	NC score	0.366727 (rank : 20)
Query Neighborhood Hits	238	Target Neighborhood Hits	156	Shared Neighborhood Hits	108
SwissProt Accessions	P84074, P32076, P41211, P70510	Gene names	HPCA, BDR2
Domain Architecture	No domain graphic available
Description	Neuron-specific calcium-binding protein hippocalcin (Calcium-binding protein BDR-2).

HPCA_MOUSE
θ value	2.36244e-08 (rank : 26)	NC score	0.366727 (rank : 21)
Query Neighborhood Hits	238	Target Neighborhood Hits	156	Shared Neighborhood Hits	108
SwissProt Accessions	P84075, P32076, P41211, P70510	Gene names	Hpca
Domain Architecture	No domain graphic available
Description	Neuron-specific calcium-binding protein hippocalcin.

KPCE_HUMAN
θ value	2.36244e-08 (rank : 27)	NC score	0.154498 (rank : 113)
Query Neighborhood Hits	238	Target Neighborhood Hits	906	Shared Neighborhood Hits	69
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCL_MOUSE
θ value	2.36244e-08 (rank : 28)	NC score	0.154198 (rank : 114)
Query Neighborhood Hits	238	Target Neighborhood Hits	891	Shared Neighborhood Hits	70
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

HPCL1_HUMAN
θ value	3.08544e-08 (rank : 29)	NC score	0.366385 (rank : 22)
Query Neighborhood Hits	238	Target Neighborhood Hits	150	Shared Neighborhood Hits	104
SwissProt Accessions	P37235, Q969S5	Gene names	HPCAL1, BDR1
Domain Architecture
Description	Hippocalcin-like protein 1 (Visinin-like protein 3) (VILIP-3) (Calcium-binding protein BDR-1) (HLP2).

KPCE_MOUSE
θ value	3.08544e-08 (rank : 30)	NC score	0.154746 (rank : 111)
Query Neighborhood Hits	238	Target Neighborhood Hits	906	Shared Neighborhood Hits	69
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

NCALD_HUMAN
θ value	3.08544e-08 (rank : 31)	NC score	0.368571 (rank : 17)
Query Neighborhood Hits	238	Target Neighborhood Hits	153	Shared Neighborhood Hits	106
SwissProt Accessions	P61601, P29554, Q8IYC3, Q9H0W2	Gene names	NCALD
Domain Architecture
Description	Neurocalcin delta.

NCALD_MOUSE
θ value	3.08544e-08 (rank : 32)	NC score	0.368571 (rank : 18)
Query Neighborhood Hits	238	Target Neighborhood Hits	153	Shared Neighborhood Hits	106
SwissProt Accessions	Q91X97, Q3TJS9, Q8BZN9	Gene names	Ncald, D15Ertd412e
Domain Architecture
Description	Neurocalcin delta.

KPCL_HUMAN
θ value	6.87365e-08 (rank : 33)	NC score	0.157465 (rank : 105)
Query Neighborhood Hits	238	Target Neighborhood Hits	887	Shared Neighborhood Hits	70
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

GUC1A_MOUSE
θ value	8.97725e-08 (rank : 34)	NC score	0.381290 (rank : 15)
Query Neighborhood Hits	238	Target Neighborhood Hits	152	Shared Neighborhood Hits	115
SwissProt Accessions	P43081	Gene names	Guca1a, Gcap, Gcap1, Guca1
Domain Architecture
Description	Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A).

KPCT_HUMAN
θ value	8.97725e-08 (rank : 35)	NC score	0.150990 (rank : 124)
Query Neighborhood Hits	238	Target Neighborhood Hits	897	Shared Neighborhood Hits	69
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_MOUSE
θ value	8.97725e-08 (rank : 36)	NC score	0.151407 (rank : 122)
Query Neighborhood Hits	238	Target Neighborhood Hits	895	Shared Neighborhood Hits	69
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

GUC1B_HUMAN
θ value	9.92553e-07 (rank : 37)	NC score	0.358010 (rank : 25)
Query Neighborhood Hits	238	Target Neighborhood Hits	124	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UMX6, Q9NU15	Gene names	GUCA1B, GCAP2
Domain Architecture
Description	Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B).

MRCKG_MOUSE
θ value	9.92553e-07 (rank : 38)	NC score	0.125154 (rank : 140)
Query Neighborhood Hits	238	Target Neighborhood Hits	1466	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

KIP1_MOUSE
θ value	2.21117e-06 (rank : 39)	NC score	0.361798 (rank : 24)
Query Neighborhood Hits	238	Target Neighborhood Hits	109	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z0F4, Q3TN80	Gene names	Cib1, Cib, Kip, Prkdcip
Domain Architecture
Description	Calcium and integrin-binding protein 1 (Calmyrin) (DNA-PKcs- interacting protein) (Kinase-interacting protein) (KIP) (CIB).

KIP1_HUMAN
θ value	2.88788e-06 (rank : 40)	NC score	0.350796 (rank : 27)
Query Neighborhood Hits	238	Target Neighborhood Hits	105	Shared Neighborhood Hits	87
SwissProt Accessions	Q99828, O00693, O00735, Q6IB49, Q96J54, Q99971	Gene names	CIB1, CIB, KIP, PRKDCIP
Domain Architecture
Description	Calcium and integrin-binding protein 1 (Calmyrin) (DNA-PKcs- interacting protein) (Kinase-interacting protein) (KIP) (CIB) (SNK- interacting protein 2-28) (SIP2-28).

MRCKG_HUMAN
θ value	2.88788e-06 (rank : 41)	NC score	0.122624 (rank : 141)
Query Neighborhood Hits	238	Target Neighborhood Hits	1519	Shared Neighborhood Hits	62
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

KPCD2_HUMAN
θ value	3.77169e-06 (rank : 42)	NC score	0.112910 (rank : 152)
Query Neighborhood Hits	238	Target Neighborhood Hits	910	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCZ_HUMAN
θ value	3.77169e-06 (rank : 43)	NC score	0.135670 (rank : 132)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	70
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

GUC1C_HUMAN
θ value	4.92598e-06 (rank : 44)	NC score	0.362420 (rank : 23)
Query Neighborhood Hits	238	Target Neighborhood Hits	148	Shared Neighborhood Hits	111
SwissProt Accessions	O95843, O95844, Q9UNM0	Gene names	GUCA1C, GCAP3
Domain Architecture
Description	Guanylyl cyclase-activating protein 3 (GCAP 3) (Guanylate cyclase activator 1C).

KPCZ_MOUSE
θ value	6.43352e-06 (rank : 45)	NC score	0.136671 (rank : 131)
Query Neighborhood Hits	238	Target Neighborhood Hits	882	Shared Neighborhood Hits	69
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCD3_HUMAN
θ value	1.09739e-05 (rank : 46)	NC score	0.119092 (rank : 147)
Query Neighborhood Hits	238	Target Neighborhood Hits	895	Shared Neighborhood Hits	68
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
θ value	1.09739e-05 (rank : 47)	NC score	0.117833 (rank : 148)
Query Neighborhood Hits	238	Target Neighborhood Hits	901	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

CSEN_HUMAN
θ value	1.43324e-05 (rank : 48)	NC score	0.320153 (rank : 47)
Query Neighborhood Hits	238	Target Neighborhood Hits	128	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y2W7, Q53TJ5, Q96T40, Q9UJ84, Q9UJ85	Gene names	KCNIP3, CSEN, DREAM, KCHIP3
Domain Architecture
Description	Calsenilin (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3).

KCIP1_MOUSE
θ value	1.43324e-05 (rank : 49)	NC score	0.333202 (rank : 34)
Query Neighborhood Hits	238	Target Neighborhood Hits	113	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JJ57, Q5SSA3, Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2	Gene names	Kcnip1, Kchip1
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 1 (KChIP1) (A-type potassium channel modulatory protein 1) (Potassium channel-interacting protein 1).

HPCL4_HUMAN
θ value	1.87187e-05 (rank : 50)	NC score	0.336450 (rank : 31)
Query Neighborhood Hits	238	Target Neighborhood Hits	123	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UM19, Q5TG97, Q8N611	Gene names	HPCAL4
Domain Architecture	No domain graphic available
Description	Hippocalcin-like protein 4 (HLP4).

HPCL4_MOUSE
θ value	1.87187e-05 (rank : 51)	NC score	0.336622 (rank : 30)
Query Neighborhood Hits	238	Target Neighborhood Hits	123	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BGZ1	Gene names	Hpcal4
Domain Architecture	No domain graphic available
Description	Hippocalcin-like protein 4 (Neural visinin-like protein 2) (NVP-2).

KPCD1_MOUSE
θ value	1.87187e-05 (rank : 52)	NC score	0.113530 (rank : 151)
Query Neighborhood Hits	238	Target Neighborhood Hits	891	Shared Neighborhood Hits	68
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KCIP1_HUMAN
θ value	2.44474e-05 (rank : 53)	NC score	0.332364 (rank : 35)
Query Neighborhood Hits	238	Target Neighborhood Hits	113	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NZI2, Q5U822	Gene names	KCNIP1, KCHIP1, VABP
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 1 (KChIP1) (A-type potassium channel modulatory protein 1) (Potassium channel-interacting protein 1) (Vesicle APC-binding protein).

KPCD1_HUMAN
θ value	2.44474e-05 (rank : 54)	NC score	0.112872 (rank : 153)
Query Neighborhood Hits	238	Target Neighborhood Hits	901	Shared Neighborhood Hits	68
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MRCKA_HUMAN
θ value	3.19293e-05 (rank : 55)	NC score	0.113919 (rank : 150)
Query Neighborhood Hits	238	Target Neighborhood Hits	1999	Shared Neighborhood Hits	69
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

CANB2_MOUSE
θ value	4.1701e-05 (rank : 56)	NC score	0.340583 (rank : 28)
Query Neighborhood Hits	238	Target Neighborhood Hits	173	Shared Neighborhood Hits	111
SwissProt Accessions	Q63811	Gene names	Ppp3r2
Domain Architecture
Description	Calcineurin subunit B isoform 2 (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform).

CANB1_HUMAN
θ value	5.44631e-05 (rank : 57)	NC score	0.333845 (rank : 33)
Query Neighborhood Hits	238	Target Neighborhood Hits	183	Shared Neighborhood Hits	109
SwissProt Accessions	P63098, P06705, P15117, Q08044	Gene names	PPP3R1, CNA2, CNB
Domain Architecture	No domain graphic available
Description	Calcineurin subunit B isoform 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1).

CANB1_MOUSE
θ value	5.44631e-05 (rank : 58)	NC score	0.333861 (rank : 32)
Query Neighborhood Hits	238	Target Neighborhood Hits	183	Shared Neighborhood Hits	109
SwissProt Accessions	Q63810	Gene names	Ppp3r1, Cnb
Domain Architecture
Description	Calcineurin subunit B isoform 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1).

KPCI_HUMAN
θ value	5.44631e-05 (rank : 59)	NC score	0.128527 (rank : 137)
Query Neighborhood Hits	238	Target Neighborhood Hits	885	Shared Neighborhood Hits	66
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	5.44631e-05 (rank : 60)	NC score	0.128654 (rank : 136)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	68
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

MRCKB_HUMAN
θ value	5.44631e-05 (rank : 61)	NC score	0.108283 (rank : 157)
Query Neighborhood Hits	238	Target Neighborhood Hits	2239	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

GUC1B_MOUSE
θ value	7.1131e-05 (rank : 62)	NC score	0.355739 (rank : 26)
Query Neighborhood Hits	238	Target Neighborhood Hits	116	Shared Neighborhood Hits	90
SwissProt Accessions	Q8VBV8	Gene names	Guca1b
Domain Architecture	No domain graphic available
Description	Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B).

EFCB1_HUMAN
θ value	9.29e-05 (rank : 63)	NC score	0.338671 (rank : 29)
Query Neighborhood Hits	238	Target Neighborhood Hits	121	Shared Neighborhood Hits	97
SwissProt Accessions	Q9HAE3	Gene names	EFCAB1
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 1.

MRCKB_MOUSE
θ value	9.29e-05 (rank : 64)	NC score	0.110596 (rank : 154)
Query Neighborhood Hits	238	Target Neighborhood Hits	2180	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

CALM_HUMAN
θ value	0.000121331 (rank : 65)	NC score	0.208113 (rank : 72)
Query Neighborhood Hits	238	Target Neighborhood Hits	232	Shared Neighborhood Hits	112
SwissProt Accessions	P62158, P02593, P70667, P99014, Q13942, Q53S29, Q61379, Q61380, Q96HK3	Gene names	CALM1, CALM, CAM, CAM1
Domain Architecture
Description	Calmodulin (CaM).

CALM_MOUSE
θ value	0.000121331 (rank : 66)	NC score	0.208113 (rank : 73)
Query Neighborhood Hits	238	Target Neighborhood Hits	232	Shared Neighborhood Hits	112
SwissProt Accessions	P62204, P02593, P70667, P99014, Q61379, Q61380	Gene names	Calm1, Calm, Cam, Cam1
Domain Architecture
Description	Calmodulin (CaM).

STAC_MOUSE
θ value	0.000121331 (rank : 67)	NC score	0.248222 (rank : 56)
Query Neighborhood Hits	238	Target Neighborhood Hits	268	Shared Neighborhood Hits	64
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

CSEN_MOUSE
θ value	0.000158464 (rank : 68)	NC score	0.314710 (rank : 48)
Query Neighborhood Hits	238	Target Neighborhood Hits	117	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QXT8, Q924L0, Q99PH9, Q99PI0, Q99PI2, Q99PI3, Q9JHZ5	Gene names	Kcnip3, Csen, Dream, Kchip3
Domain Architecture
Description	Calsenilin (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (A-type potassium channel modulatory protein 3) (KChIP3).

STAC_HUMAN
θ value	0.000158464 (rank : 69)	NC score	0.239927 (rank : 57)
Query Neighborhood Hits	238	Target Neighborhood Hits	276	Shared Neighborhood Hits	64
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VISL1_HUMAN
θ value	0.000158464 (rank : 70)	NC score	0.328504 (rank : 42)
Query Neighborhood Hits	238	Target Neighborhood Hits	124	Shared Neighborhood Hits	93
SwissProt Accessions	P62760, P28677, P29103, P42323, Q9UM20	Gene names	VSNL1, VISL1
Domain Architecture	No domain graphic available
Description	Visinin-like protein 1 (VILIP) (Hippocalcin-like protein 3) (HLP3).

VISL1_MOUSE
θ value	0.000158464 (rank : 71)	NC score	0.328504 (rank : 43)
Query Neighborhood Hits	238	Target Neighborhood Hits	124	Shared Neighborhood Hits	93
SwissProt Accessions	P62761, P28677, P29103, P42323, Q9UM20	Gene names	Vsnl1, Visl1
Domain Architecture	No domain graphic available
Description	Visinin-like protein 1 (VILIP) (Neural visinin-like protein 1) (NVL-1) (NVP-1).

KCIP2_HUMAN
θ value	0.00020696 (rank : 72)	NC score	0.330224 (rank : 39)
Query Neighborhood Hits	238	Target Neighborhood Hits	125	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NS61, Q7Z6F1, Q96K86, Q96T41, Q96T42, Q96T43, Q96T44, Q9H0N4, Q9HD10, Q9HD11, Q9NS60, Q9NY10, Q9NZI1	Gene names	KCNIP2, KCHIP2
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Potassium channel-interacting protein 2) (Cardiac voltage-gated potassium channel modulatory subunit).

EFCB1_MOUSE
θ value	0.000270298 (rank : 73)	NC score	0.320383 (rank : 46)
Query Neighborhood Hits	238	Target Neighborhood Hits	126	Shared Neighborhood Hits	98
SwissProt Accessions	Q9D3N2, Q8BSW3, Q8C982, Q8CAI0, Q9D527, Q9D5E7	Gene names	Efcab1
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 1.

GRP3_HUMAN
θ value	0.000270298 (rank : 74)	NC score	0.295170 (rank : 50)
Query Neighborhood Hits	238	Target Neighborhood Hits	131	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

KCIP2_MOUSE
θ value	0.000270298 (rank : 75)	NC score	0.328053 (rank : 44)
Query Neighborhood Hits	238	Target Neighborhood Hits	124	Shared Neighborhood Hits	95
SwissProt Accessions	Q9JJ69, Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68	Gene names	Kcnip2, Kchip2
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Potassium channel-interacting protein 2).

STAC3_HUMAN
θ value	0.000270298 (rank : 76)	NC score	0.231893 (rank : 60)
Query Neighborhood Hits	238	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.000270298 (rank : 77)	NC score	0.232088 (rank : 59)
Query Neighborhood Hits	238	Target Neighborhood Hits	232	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CHIO_HUMAN
θ value	0.00035302 (rank : 78)	NC score	0.209020 (rank : 71)
Query Neighborhood Hits	238	Target Neighborhood Hits	220	Shared Neighborhood Hits	66
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	0.00035302 (rank : 79)	NC score	0.217563 (rank : 64)
Query Neighborhood Hits	238	Target Neighborhood Hits	130	Shared Neighborhood Hits	66
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

KCIP4_HUMAN
θ value	0.000602161 (rank : 80)	NC score	0.329436 (rank : 41)
Query Neighborhood Hits	238	Target Neighborhood Hits	136	Shared Neighborhood Hits	101
SwissProt Accessions	Q6PIL6, Q4W5G8, Q8NEU0, Q9BWT2, Q9H294, Q9H2A4	Gene names	KCNIP4, CALP, KCHIP4
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) (Calsenilin-like protein).

KCIP4_MOUSE
θ value	0.000602161 (rank : 81)	NC score	0.329557 (rank : 40)
Query Neighborhood Hits	238	Target Neighborhood Hits	136	Shared Neighborhood Hits	101
SwissProt Accessions	Q6PHZ8, Q6DTJ3, Q8CAD0, Q8R4I2, Q9EQ01	Gene names	Kcnip4, Calp, Kchip4
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) (Calsenilin-like protein).

NCS1_HUMAN
θ value	0.000602161 (rank : 82)	NC score	0.331117 (rank : 36)
Query Neighborhood Hits	238	Target Neighborhood Hits	132	Shared Neighborhood Hits	101
SwissProt Accessions	P62166, P36610, Q9UK26	Gene names	FREQ, FLUP, NCS1
Domain Architecture
Description	Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein).

NCS1_MOUSE
θ value	0.000602161 (rank : 83)	NC score	0.331117 (rank : 37)
Query Neighborhood Hits	238	Target Neighborhood Hits	132	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BNY6	Gene names	Freq, Ncs1
Domain Architecture
Description	Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog).

CABP7_HUMAN
θ value	0.000786445 (rank : 84)	NC score	0.212105 (rank : 66)
Query Neighborhood Hits	238	Target Neighborhood Hits	205	Shared Neighborhood Hits	104
SwissProt Accessions	Q86V35	Gene names	CABP7
Domain Architecture
Description	Calcium-binding protein 7 (CaBP7).

CABP7_MOUSE
θ value	0.000786445 (rank : 85)	NC score	0.212105 (rank : 67)
Query Neighborhood Hits	238	Target Neighborhood Hits	205	Shared Neighborhood Hits	104
SwissProt Accessions	Q91ZM8	Gene names	Cabp7
Domain Architecture
Description	Calcium-binding protein 7 (CaBP7).

CALL3_HUMAN
θ value	0.000786445 (rank : 86)	NC score	0.205161 (rank : 74)
Query Neighborhood Hits	238	Target Neighborhood Hits	225	Shared Neighborhood Hits	112
SwissProt Accessions	P27482	Gene names	CALML3
Domain Architecture
Description	Calmodulin-like protein 3 (Calmodulin-related protein NB-1) (CaM-like protein) (CLP).

CANB2_HUMAN
θ value	0.000786445 (rank : 87)	NC score	0.331037 (rank : 38)
Query Neighborhood Hits	238	Target Neighborhood Hits	163	Shared Neighborhood Hits	106
SwissProt Accessions	Q96LZ3, Q7Z4V8, Q8WYJ4	Gene names	PPP3R2, CBLP
Domain Architecture	No domain graphic available
Description	Calcineurin subunit B isoform 2 (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform) (Calcineurin B-like protein) (CBLP) (CNBII).

RECO_MOUSE
θ value	0.000786445 (rank : 88)	NC score	0.325595 (rank : 45)
Query Neighborhood Hits	238	Target Neighborhood Hits	108	Shared Neighborhood Hits	79
SwissProt Accessions	P34057	Gene names	Rcvrn, Rcv1
Domain Architecture
Description	Recoverin (Cancer-associated retinopathy protein) (Protein CAR) (23 kDa photoreceptor cell-specific protein).

UBP32_HUMAN
θ value	0.00134147 (rank : 89)	NC score	0.151918 (rank : 119)
Query Neighborhood Hits	238	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NFA0, Q9BX85, Q9Y591	Gene names	USP32, USP10
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.1.2.15) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) (Deubiquitinating enzyme 32) (NY-REN-60 antigen).

CHIN_HUMAN
θ value	0.00298849 (rank : 90)	NC score	0.204645 (rank : 76)
Query Neighborhood Hits	238	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	0.00298849 (rank : 91)	NC score	0.200673 (rank : 79)
Query Neighborhood Hits	238	Target Neighborhood Hits	229	Shared Neighborhood Hits	64
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RASF1_MOUSE
θ value	0.00390308 (rank : 92)	NC score	0.261933 (rank : 55)
Query Neighborhood Hits	238	Target Neighborhood Hits	74	Shared Neighborhood Hits	58
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

MYO9B_HUMAN
θ value	0.00509761 (rank : 93)	NC score	0.068296 (rank : 288)
Query Neighborhood Hits	238	Target Neighborhood Hits	641	Shared Neighborhood Hits	56
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

2ACA_HUMAN
θ value	0.00665767 (rank : 94)	NC score	0.066537 (rank : 294)
Query Neighborhood Hits	238	Target Neighborhood Hits	100	Shared Neighborhood Hits	6
SwissProt Accessions	Q06190, Q06189, Q9NPQ5	Gene names	PPP2R3A, PPP2R3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B (PP2A, subunit B, B''-PR72/PR130) (PP2A, subunit B, B72/B130 isoforms) (PP2A, subunit B, PR72/PR130 isoforms) (PP2A, subunit B, R3 isoform).

DUOX1_HUMAN
θ value	0.00665767 (rank : 95)	NC score	0.195131 (rank : 81)
Query Neighborhood Hits	238	Target Neighborhood Hits	172	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NRD9, Q6ZMB3, Q6ZR09, Q9NZC1	Gene names	DUOX1, DUOX, LNOX1, THOX1
Domain Architecture	No domain graphic available
Description	Dual oxidase 1 precursor (EC 1.6.3.1) (EC 1.11.1.-) (NADPH thyroid oxidase 1) (Thyroid oxidase 1) (Large NOX 1) (Long NOX 1).

RECO_HUMAN
θ value	0.00665767 (rank : 96)	NC score	0.314402 (rank : 49)
Query Neighborhood Hits	238	Target Neighborhood Hits	101	Shared Neighborhood Hits	76
SwissProt Accessions	P35243	Gene names	RCVRN, RCV1
Domain Architecture
Description	Recoverin (Cancer-associated retinopathy protein) (Protein CAR).

DUOX2_HUMAN
θ value	0.0113563 (rank : 97)	NC score	0.193247 (rank : 82)
Query Neighborhood Hits	238	Target Neighborhood Hits	139	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NRD8, Q9NR02, Q9UHF9	Gene names	DUOX2, LNOX2, THOX2
Domain Architecture	No domain graphic available
Description	Dual oxidase 2 precursor (EC 1.6.3.1) (EC 1.11.1.-) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (NADH/NADPH thyroid oxidase p138-tox) (p138 thyroid oxidase) (Large NOX 2) (Long NOX 2).

EFHD1_HUMAN
θ value	0.0113563 (rank : 98)	NC score	0.174166 (rank : 90)
Query Neighborhood Hits	238	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BUP0, Q9BTF8, Q9H8I2, Q9HBQ0	Gene names	EFHD1, SWS2
Domain Architecture
Description	EF-hand domain-containing protein 1 (Swiprosin-2).

MYO9B_MOUSE
θ value	0.0113563 (rank : 99)	NC score	0.068400 (rank : 287)
Query Neighborhood Hits	238	Target Neighborhood Hits	311	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CALB1_HUMAN
θ value	0.0148317 (rank : 100)	NC score	0.176187 (rank : 87)
Query Neighborhood Hits	238	Target Neighborhood Hits	130	Shared Neighborhood Hits	87
SwissProt Accessions	P05937	Gene names	CALB1, CAB27
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K).

CALB1_MOUSE
θ value	0.0148317 (rank : 101)	NC score	0.175404 (rank : 88)
Query Neighborhood Hits	238	Target Neighborhood Hits	129	Shared Neighborhood Hits	86
SwissProt Accessions	P12658, Q545N6	Gene names	Calb1
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K) (Spot 35 protein) (PCD-29).

KIP3_HUMAN
θ value	0.0148317 (rank : 102)	NC score	0.214512 (rank : 65)
Query Neighborhood Hits	238	Target Neighborhood Hits	83	Shared Neighborhood Hits	75
SwissProt Accessions	Q96Q77	Gene names	CIB3, KIP3
Domain Architecture
Description	Calcium and integrin-binding protein 3 (Kinase-interacting protein 3) (KIP 3).

RAF1_HUMAN
θ value	0.0148317 (rank : 103)	NC score	0.076002 (rank : 253)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	62
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	0.0148317 (rank : 104)	NC score	0.076634 (rank : 248)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	62
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

UN13B_HUMAN
θ value	0.0193708 (rank : 105)	NC score	0.220189 (rank : 62)
Query Neighborhood Hits	238	Target Neighborhood Hits	217	Shared Neighborhood Hits	68
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CHP2_MOUSE
θ value	0.0252991 (rank : 106)	NC score	0.290514 (rank : 51)
Query Neighborhood Hits	238	Target Neighborhood Hits	122	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D869	Gene names	Chp2, Hca520
Domain Architecture
Description	Calcineurin B homologous protein 2 (Hepatocellular carcinoma- associated antigen 520 homolog).

TNNC1_MOUSE
θ value	0.0252991 (rank : 107)	NC score	0.209718 (rank : 69)
Query Neighborhood Hits	238	Target Neighborhood Hits	221	Shared Neighborhood Hits	111
SwissProt Accessions	P19123	Gene names	Tnnc1, Tncc
Domain Architecture
Description	Troponin C, slow skeletal and cardiac muscles (TN-C).

FSTL5_MOUSE
θ value	0.0330416 (rank : 108)	NC score	0.055435 (rank : 470)
Query Neighborhood Hits	238	Target Neighborhood Hits	355	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

NUCB2_MOUSE
θ value	0.0330416 (rank : 109)	NC score	0.094823 (rank : 165)
Query Neighborhood Hits	238	Target Neighborhood Hits	459	Shared Neighborhood Hits	52
SwissProt Accessions	P81117	Gene names	Nucb2, Nefa
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA).

TNNC1_HUMAN
θ value	0.0330416 (rank : 110)	NC score	0.209814 (rank : 68)
Query Neighborhood Hits	238	Target Neighborhood Hits	219	Shared Neighborhood Hits	111
SwissProt Accessions	P63316, O14800, P02590, P04463	Gene names	TNNC1, TNNC
Domain Architecture	No domain graphic available
Description	Troponin C, slow skeletal and cardiac muscles (TN-C).

CALL6_HUMAN
θ value	0.0431538 (rank : 111)	NC score	0.133800 (rank : 133)
Query Neighborhood Hits	238	Target Neighborhood Hits	157	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TD86, Q6Q2C4	Gene names	CALML6, CAGLP, CALGP
Domain Architecture	No domain graphic available
Description	Calmodulin-like protein 6 (Calglandulin-like protein).

CHP1_MOUSE
θ value	0.0431538 (rank : 112)	NC score	0.281466 (rank : 52)
Query Neighborhood Hits	238	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P61022, Q62877, Q6ZWQ8	Gene names	Chp, Sid470
Domain Architecture
Description	Calcium-binding protein p22 (Calcium-binding protein CHP) (Calcineurin homologous protein) (Sid 470).

NOX5_HUMAN
θ value	0.0431538 (rank : 113)	NC score	0.170398 (rank : 92)
Query Neighborhood Hits	238	Target Neighborhood Hits	89	Shared Neighborhood Hits	65
SwissProt Accessions	Q96PH1, Q8TEQ1, Q8TER4, Q96PH2, Q96PJ8, Q96PJ9, Q9H6E0, Q9HAM8	Gene names	NOX5
Domain Architecture	No domain graphic available
Description	NADPH oxidase 5 (EC 1.6.3.-).

UN13A_HUMAN
θ value	0.0431538 (rank : 114)	NC score	0.219232 (rank : 63)
Query Neighborhood Hits	238	Target Neighborhood Hits	285	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

CALN1_HUMAN
θ value	0.0563607 (rank : 115)	NC score	0.164524 (rank : 98)
Query Neighborhood Hits	238	Target Neighborhood Hits	161	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BXU9	Gene names	CALN1, CABP8
Domain Architecture
Description	Calneuron-1 (Calcium-binding protein CaBP8).

CALN1_MOUSE
θ value	0.0563607 (rank : 116)	NC score	0.164259 (rank : 99)
Query Neighborhood Hits	238	Target Neighborhood Hits	161	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JJG7	Gene names	Caln1
Domain Architecture
Description	Calneuron-1.

CHP1_HUMAN
θ value	0.0563607 (rank : 117)	NC score	0.276439 (rank : 54)
Query Neighborhood Hits	238	Target Neighborhood Hits	114	Shared Neighborhood Hits	91
SwissProt Accessions	Q99653	Gene names	CHP
Domain Architecture
Description	Calcium-binding protein p22 (Calcium-binding protein CHP) (Calcineurin homologous protein) (Calcineurin B homolog).

EFHD1_MOUSE
θ value	0.0563607 (rank : 118)	NC score	0.161697 (rank : 103)
Query Neighborhood Hits	238	Target Neighborhood Hits	108	Shared Neighborhood Hits	75
SwissProt Accessions	Q9D4J1, Q543U4	Gene names	Efhd1, Sws2
Domain Architecture
Description	EF-hand domain-containing protein 1 (Swiprosin-2).

TNNC2_MOUSE
θ value	0.0563607 (rank : 119)	NC score	0.204661 (rank : 75)
Query Neighborhood Hits	238	Target Neighborhood Hits	233	Shared Neighborhood Hits	110
SwissProt Accessions	P20801	Gene names	Tnnc2, Tncs
Domain Architecture
Description	Troponin C, skeletal muscle (STNC).

CALB2_HUMAN
θ value	0.0736092 (rank : 120)	NC score	0.189023 (rank : 85)
Query Neighborhood Hits	238	Target Neighborhood Hits	149	Shared Neighborhood Hits	94
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

CALB2_MOUSE
θ value	0.0736092 (rank : 121)	NC score	0.191659 (rank : 84)
Query Neighborhood Hits	238	Target Neighborhood Hits	141	Shared Neighborhood Hits	93
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

CHP2_HUMAN
θ value	0.0736092 (rank : 122)	NC score	0.278199 (rank : 53)
Query Neighborhood Hits	238	Target Neighborhood Hits	122	Shared Neighborhood Hits	91
SwissProt Accessions	O43745	Gene names	CHP2, HCA520
Domain Architecture
Description	Calcineurin B homologous protein 2 (Hepatocellular carcinoma- associated antigen 520).

NUCB2_HUMAN
θ value	0.0736092 (rank : 123)	NC score	0.095228 (rank : 164)
Query Neighborhood Hits	238	Target Neighborhood Hits	321	Shared Neighborhood Hits	50
SwissProt Accessions	P80303, Q8NFT5	Gene names	NUCB2, NEFA
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA) (Gastric cancer antigen Zg4).

UN13B_MOUSE
θ value	0.0736092 (rank : 124)	NC score	0.209229 (rank : 70)
Query Neighborhood Hits	238	Target Neighborhood Hits	210	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	0.0736092 (rank : 125)	NC score	0.096917 (rank : 161)
Query Neighborhood Hits	238	Target Neighborhood Hits	453	Shared Neighborhood Hits	61
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.0736092 (rank : 126)	NC score	0.092026 (rank : 169)
Query Neighborhood Hits	238	Target Neighborhood Hits	456	Shared Neighborhood Hits	58
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

BRAF1_HUMAN
θ value	0.0961366 (rank : 127)	NC score	0.067682 (rank : 290)
Query Neighborhood Hits	238	Target Neighborhood Hits	883	Shared Neighborhood Hits	60
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

ARAF_HUMAN
θ value	0.125558 (rank : 128)	NC score	0.067341 (rank : 293)
Query Neighborhood Hits	238	Target Neighborhood Hits	924	Shared Neighborhood Hits	60
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	0.125558 (rank : 129)	NC score	0.068922 (rank : 284)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	58
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

PLSL_MOUSE
θ value	0.125558 (rank : 130)	NC score	0.094113 (rank : 166)
Query Neighborhood Hits	238	Target Neighborhood Hits	170	Shared Neighborhood Hits	81
SwissProt Accessions	Q61233, Q3UE24, Q8R1X3, Q9CV77	Gene names	Lcp1, Pls2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (pp65).

SEGN_HUMAN
θ value	0.125558 (rank : 131)	NC score	0.139301 (rank : 130)
Query Neighborhood Hits	238	Target Neighborhood Hits	96	Shared Neighborhood Hits	72
SwissProt Accessions	O76038, Q5VV44, Q96QV7, Q9UJF6	Gene names	SCGN, SECRET
Domain Architecture
Description	Secretagogin.

CALM4_MOUSE
θ value	0.163984 (rank : 132)	NC score	0.204057 (rank : 77)
Query Neighborhood Hits	238	Target Neighborhood Hits	229	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JM83, Q9CR31, Q9D1E9	Gene names	Calm4, Dd112
Domain Architecture
Description	Calmodulin-4 (Calcium-binding protein Dd112).

NTNG2_MOUSE
θ value	0.163984 (rank : 133)	NC score	0.019859 (rank : 593)
Query Neighborhood Hits	238	Target Neighborhood Hits	276	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R4F1, Q8R4F2, Q8VIP6, Q8VIP7, Q8VIP8	Gene names	Ntng2, Lmnt2
Domain Architecture
Description	Netrin G2 precursor (Laminet-2).

PLSL_HUMAN
θ value	0.163984 (rank : 134)	NC score	0.092785 (rank : 167)
Query Neighborhood Hits	238	Target Neighborhood Hits	168	Shared Neighborhood Hits	82
SwissProt Accessions	P13796	Gene names	LCP1, PLS2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P).

2ACC_HUMAN
θ value	0.21417 (rank : 135)	NC score	0.045437 (rank : 586)
Query Neighborhood Hits	238	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y5P8	Gene names	PPP2R3B, PPP2R3L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 48 kDa regulatory subunit B (PP2A, subunit B, PR48 isoform).

CABP4_HUMAN
θ value	0.21417 (rank : 136)	NC score	0.174421 (rank : 89)
Query Neighborhood Hits	238	Target Neighborhood Hits	250	Shared Neighborhood Hits	106
SwissProt Accessions	P57796, Q8N4Z2, Q8WWY5	Gene names	CABP4
Domain Architecture
Description	Calcium-binding protein 4 (CaBP4).

TNNC2_HUMAN
θ value	0.21417 (rank : 137)	NC score	0.201900 (rank : 78)
Query Neighborhood Hits	238	Target Neighborhood Hits	234	Shared Neighborhood Hits	111
SwissProt Accessions	P02585	Gene names	TNNC2
Domain Architecture
Description	Troponin C, skeletal muscle.

ZN592_MOUSE
θ value	0.21417 (rank : 138)	NC score	0.013757 (rank : 596)
Query Neighborhood Hits	238	Target Neighborhood Hits	768	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BHZ4, Q80XM1	Gene names	Znf592, Kiaa0211, Zfp592
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592 (Zfp-592).

EFHD2_MOUSE
θ value	0.279714 (rank : 139)	NC score	0.120174 (rank : 145)
Query Neighborhood Hits	238	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9D8Y0, Q9D0P4	Gene names	Efhd2, Sws1
Domain Architecture
Description	EF-hand domain-containing protein 2 (Swiprosin-1).

FSTL4_HUMAN
θ value	0.279714 (rank : 140)	NC score	0.028084 (rank : 591)
Query Neighborhood Hits	238	Target Neighborhood Hits	344	Shared Neighborhood Hits	18
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

RASF5_MOUSE
θ value	0.279714 (rank : 141)	NC score	0.098904 (rank : 160)
Query Neighborhood Hits	238	Target Neighborhood Hits	72	Shared Neighborhood Hits	47
SwissProt Accessions	Q5EBH1, O70407, Q6KAR0, Q8C2E8	Gene names	Rassf5, Nore1, Rapl
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

EFHD2_HUMAN
θ value	0.365318 (rank : 142)	NC score	0.116609 (rank : 149)
Query Neighborhood Hits	238	Target Neighborhood Hits	86	Shared Neighborhood Hits	59
SwissProt Accessions	Q96C19	Gene names	EFHD2, SWS1
Domain Architecture
Description	EF-hand domain-containing protein 2 (Swiprosin-1).

PPE2_MOUSE
θ value	0.365318 (rank : 143)	NC score	0.057917 (rank : 429)
Query Neighborhood Hits	238	Target Neighborhood Hits	112	Shared Neighborhood Hits	65
SwissProt Accessions	O35385	Gene names	Ppef2
Domain Architecture
Description	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2).

CABP1_HUMAN
θ value	0.47712 (rank : 144)	NC score	0.152460 (rank : 117)
Query Neighborhood Hits	238	Target Neighborhood Hits	197	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NZU7, O95663, Q9NZU8	Gene names	CABP1
Domain Architecture
Description	Calcium-binding protein 1 (CaBP1) (Calbrain).

CABP1_MOUSE
θ value	0.47712 (rank : 145)	NC score	0.152410 (rank : 118)
Query Neighborhood Hits	238	Target Neighborhood Hits	197	Shared Neighborhood Hits	96
SwissProt Accessions	Q9JLK7, Q9JLK6	Gene names	Cabp1
Domain Architecture
Description	Calcium-binding protein 1 (CaBP1).

GPDM_HUMAN
θ value	0.47712 (rank : 146)	NC score	0.092544 (rank : 168)
Query Neighborhood Hits	238	Target Neighborhood Hits	116	Shared Neighborhood Hits	68
SwissProt Accessions	P43304, Q59FR1, Q9HAP9	Gene names	GPD2
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M) (mtGPD).

PPE2_HUMAN
θ value	0.47712 (rank : 147)	NC score	0.060555 (rank : 373)
Query Neighborhood Hits	238	Target Neighborhood Hits	106	Shared Neighborhood Hits	58
SwissProt Accessions	O14830, O14831	Gene names	PPEF2
Domain Architecture
Description	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2).

TESC_MOUSE
θ value	0.47712 (rank : 148)	NC score	0.148733 (rank : 126)
Query Neighborhood Hits	238	Target Neighborhood Hits	63	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JKL5	Gene names	Tesc
Domain Architecture	No domain graphic available
Description	Tescalcin (TSC).

ZN611_HUMAN
θ value	0.47712 (rank : 149)	NC score	0.006749 (rank : 616)
Query Neighborhood Hits	238	Target Neighborhood Hits	769	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N823, Q69YG9	Gene names	ZNF611
Domain Architecture	No domain graphic available
Description	Zinc finger protein 611.

ZN700_HUMAN
θ value	0.47712 (rank : 150)	NC score	0.006342 (rank : 617)
Query Neighborhood Hits	238	Target Neighborhood Hits	772	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H0M5	Gene names	ZNF700
Domain Architecture	No domain graphic available
Description	Zinc finger protein 700.

ZNF73_HUMAN
θ value	0.47712 (rank : 151)	NC score	0.006177 (rank : 620)
Query Neighborhood Hits	238	Target Neighborhood Hits	716	Shared Neighborhood Hits	28
SwissProt Accessions	O43830, Q9UC08	Gene names	ZNF73, ZNF186
Domain Architecture	No domain graphic available
Description	Zinc finger protein 73 (Zinc finger protein 186) (hZNF2).

CALL5_HUMAN
θ value	0.62314 (rank : 152)	NC score	0.196983 (rank : 80)
Query Neighborhood Hits	238	Target Neighborhood Hits	231	Shared Neighborhood Hits	111
SwissProt Accessions	Q9NZT1, Q8IXU8	Gene names	CALML5, CLSP
Domain Architecture
Description	Calmodulin-like protein 5 (Calmodulin-like skin protein).

FSTL5_HUMAN
θ value	0.62314 (rank : 153)	NC score	0.036164 (rank : 589)
Query Neighborhood Hits	238	Target Neighborhood Hits	347	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

KIP2_HUMAN
θ value	0.62314 (rank : 154)	NC score	0.235408 (rank : 58)
Query Neighborhood Hits	238	Target Neighborhood Hits	107	Shared Neighborhood Hits	85
SwissProt Accessions	O75838	Gene names	CIB2, KIP2
Domain Architecture	No domain graphic available
Description	Calcium and integrin-binding protein 2 (Kinase-interacting protein 2) (KIP 2).

SEGN_MOUSE
θ value	0.62314 (rank : 155)	NC score	0.130700 (rank : 134)
Query Neighborhood Hits	238	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	Q91WD9	Gene names	Scgn
Domain Architecture
Description	Secretagogin.

TESC_HUMAN
θ value	0.62314 (rank : 156)	NC score	0.153940 (rank : 115)
Query Neighborhood Hits	238	Target Neighborhood Hits	64	Shared Neighborhood Hits	56
SwissProt Accessions	Q96BS2	Gene names	TESC
Domain Architecture	No domain graphic available
Description	Tescalcin (TSC).

ZFP37_MOUSE
θ value	0.62314 (rank : 157)	NC score	0.004792 (rank : 629)
Query Neighborhood Hits	238	Target Neighborhood Hits	906	Shared Neighborhood Hits	27
SwissProt Accessions	P17141, Q62514	Gene names	Zfp37, Zfp-37
Domain Architecture
Description	Zinc finger protein 37 (Zfp-37) (Male germ cell-specific zinc finger protein).

LAMC1_HUMAN
θ value	0.813845 (rank : 158)	NC score	0.011080 (rank : 599)
Query Neighborhood Hits	238	Target Neighborhood Hits	922	Shared Neighborhood Hits	18
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

MEGF9_HUMAN
θ value	0.813845 (rank : 159)	NC score	0.010724 (rank : 601)
Query Neighborhood Hits	238	Target Neighborhood Hits	557	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

TCF17_HUMAN
θ value	0.813845 (rank : 160)	NC score	0.008470 (rank : 603)
Query Neighborhood Hits	238	Target Neighborhood Hits	797	Shared Neighborhood Hits	38
SwissProt Accessions	O60765, Q9UNJ8	Gene names	ZNF354A, EZNF, HKL1, TCF17
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Zinc finger protein eZNF).

CABP4_MOUSE
θ value	1.06291 (rank : 161)	NC score	0.170454 (rank : 91)
Query Neighborhood Hits	238	Target Neighborhood Hits	212	Shared Neighborhood Hits	104
SwissProt Accessions	Q8VHC5	Gene names	Cabp4
Domain Architecture	No domain graphic available
Description	Calcium-binding protein 4 (CaBP4).

RASF1_HUMAN
θ value	1.06291 (rank : 162)	NC score	0.187021 (rank : 86)
Query Neighborhood Hits	238	Target Neighborhood Hits	62	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

ZN624_HUMAN
θ value	1.06291 (rank : 163)	NC score	0.007157 (rank : 613)
Query Neighborhood Hits	238	Target Neighborhood Hits	775	Shared Neighborhood Hits	31
SwissProt Accessions	Q9P2J8	Gene names	ZNF624, KIAA1349
Domain Architecture	No domain graphic available
Description	Zinc finger protein 624.

BI2L1_MOUSE
θ value	1.38821 (rank : 164)	NC score	0.013561 (rank : 597)
Query Neighborhood Hits	238	Target Neighborhood Hits	197	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CETN3_HUMAN
θ value	1.38821 (rank : 165)	NC score	0.162111 (rank : 102)
Query Neighborhood Hits	238	Target Neighborhood Hits	211	Shared Neighborhood Hits	104
SwissProt Accessions	O15182, Q9BS23	Gene names	CETN3, CEN3
Domain Architecture
Description	Centrin-3.

CETN3_MOUSE
θ value	1.38821 (rank : 166)	NC score	0.162492 (rank : 101)
Query Neighborhood Hits	238	Target Neighborhood Hits	208	Shared Neighborhood Hits	104
SwissProt Accessions	O35648	Gene names	Cetn3, Cen3
Domain Architecture
Description	Centrin-3.

FRAS1_MOUSE
θ value	1.38821 (rank : 167)	NC score	0.008359 (rank : 605)
Query Neighborhood Hits	238	Target Neighborhood Hits	747	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

GP2_HUMAN
θ value	1.38821 (rank : 168)	NC score	0.011051 (rank : 600)
Query Neighborhood Hits	238	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	P55259, Q13338, Q9UIF1	Gene names	GP2
Domain Architecture
Description	Pancreatic secretory granule membrane major glycoprotein GP2 precursor (Pancreatic zymogen granule membrane protein GP-2) (ZAP75).

KIP2_MOUSE
θ value	1.38821 (rank : 169)	NC score	0.229931 (rank : 61)
Query Neighborhood Hits	238	Target Neighborhood Hits	110	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z309	Gene names	Cib2, Kip2
Domain Architecture	No domain graphic available
Description	Calcium and integrin-binding protein 2 (Kinase-interacting protein 2) (KIP 2).

KNG1_HUMAN
θ value	1.38821 (rank : 170)	NC score	0.015804 (rank : 594)
Query Neighborhood Hits	238	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	P01042, P01043	Gene names	KNG1, BDK, KNG
Domain Architecture
Description	Kininogen-1 precursor (Alpha-2-thiol proteinase inhibitor) [Contains: Kininogen-1 heavy chain; Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth- promoting factor].

ONCO_MOUSE
θ value	1.38821 (rank : 171)	NC score	0.129552 (rank : 135)
Query Neighborhood Hits	238	Target Neighborhood Hits	98	Shared Neighborhood Hits	70
SwissProt Accessions	P51879, Q62004	Gene names	Ocm
Domain Architecture
Description	Oncomodulin (OM) (Parvalbumin beta).

ZN271_MOUSE
θ value	1.38821 (rank : 172)	NC score	0.005848 (rank : 624)
Query Neighborhood Hits	238	Target Neighborhood Hits	746	Shared Neighborhood Hits	33
SwissProt Accessions	P15620	Gene names	Znf271, Zfp-35, Zfp35
Domain Architecture	No domain graphic available
Description	Zinc finger protein 271 (Zinc finger protein 35) (Zfp-35).

ZN347_HUMAN
θ value	1.38821 (rank : 173)	NC score	0.007363 (rank : 608)
Query Neighborhood Hits	238	Target Neighborhood Hits	756	Shared Neighborhood Hits	28
SwissProt Accessions	Q96SE7, Q8TCN1	Gene names	ZNF347, ZNF1111
Domain Architecture
Description	Zinc finger protein 347 (Zinc finger protein 1111).

CABP3_HUMAN
θ value	1.81305 (rank : 174)	NC score	0.166579 (rank : 96)
Query Neighborhood Hits	238	Target Neighborhood Hits	162	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZU6, Q9NYY0, Q9NZT9	Gene names	CABP3
Domain Architecture
Description	Calcium-binding protein 3 (CaBP3).

CETN1_HUMAN
θ value	1.81305 (rank : 175)	NC score	0.169027 (rank : 95)
Query Neighborhood Hits	238	Target Neighborhood Hits	232	Shared Neighborhood Hits	107
SwissProt Accessions	Q12798	Gene names	CETN1, CEN1, CETN
Domain Architecture
Description	Centrin-1 (Caltractin isoform 2).

CETN1_MOUSE
θ value	1.81305 (rank : 176)	NC score	0.165178 (rank : 97)
Query Neighborhood Hits	238	Target Neighborhood Hits	231	Shared Neighborhood Hits	106
SwissProt Accessions	P41209, Q3V119, Q9D9G9, Q9DAL6	Gene names	Cetn1, Calt
Domain Architecture
Description	Centrin-1 (Caltractin).

CTRO_HUMAN
θ value	1.81305 (rank : 177)	NC score	0.074898 (rank : 256)
Query Neighborhood Hits	238	Target Neighborhood Hits	2092	Shared Neighborhood Hits	56
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

CTRO_MOUSE
θ value	1.81305 (rank : 178)	NC score	0.071526 (rank : 278)
Query Neighborhood Hits	238	Target Neighborhood Hits	2344	Shared Neighborhood Hits	56
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

GPDM_MOUSE
θ value	1.81305 (rank : 179)	NC score	0.073611 (rank : 264)
Query Neighborhood Hits	238	Target Neighborhood Hits	101	Shared Neighborhood Hits	51
SwissProt Accessions	Q64521, Q61507	Gene names	Gpd2, Gdm1
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M).

LAMA1_MOUSE
θ value	1.81305 (rank : 180)	NC score	0.008376 (rank : 604)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	21
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

ONCO_HUMAN
θ value	1.81305 (rank : 181)	NC score	0.127696 (rank : 139)
Query Neighborhood Hits	238	Target Neighborhood Hits	88	Shared Neighborhood Hits	61
SwissProt Accessions	P32930	Gene names	OCM, OCMN
Domain Architecture
Description	Oncomodulin (OM) (Parvalbumin beta).

SPTA2_HUMAN
θ value	1.81305 (rank : 182)	NC score	0.047011 (rank : 585)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	92
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

STAB2_HUMAN
θ value	1.81305 (rank : 183)	NC score	0.005122 (rank : 627)
Query Neighborhood Hits	238	Target Neighborhood Hits	534	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

TRI47_MOUSE
θ value	1.81305 (rank : 184)	NC score	0.007159 (rank : 612)
Query Neighborhood Hits	238	Target Neighborhood Hits	295	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

ZN271_HUMAN
θ value	1.81305 (rank : 185)	NC score	0.007352 (rank : 609)
Query Neighborhood Hits	238	Target Neighborhood Hits	769	Shared Neighborhood Hits	36
SwissProt Accessions	Q14591, Q96T29, Q9BSX2, Q9UN33, Q9Y5B7	Gene names	ZNF271, ZNFEB
Domain Architecture	No domain graphic available
Description	Zinc finger protein 271 (Zinc finger protein HZF7) (Zinc finger protein ZNFphex133) (Epstein-Barr virus-induced zinc finger protein) (ZNF-EB) (CT-ZFP48) (Zinc finger protein dp) (ZNF-dp).

ZN592_HUMAN
θ value	1.81305 (rank : 186)	NC score	0.012433 (rank : 598)
Query Neighborhood Hits	238	Target Neighborhood Hits	762	Shared Neighborhood Hits	27
SwissProt Accessions	Q92610	Gene names	ZNF592, KIAA0211
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592.

FCN1_MOUSE
θ value	2.36792 (rank : 187)	NC score	0.001996 (rank : 634)
Query Neighborhood Hits	238	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	O70165	Gene names	Fcn1, Fcna
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

KLD8B_MOUSE
θ value	2.36792 (rank : 188)	NC score	0.005618 (rank : 625)
Query Neighborhood Hits	238	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2D9	Gene names	Klhdc8b
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 8B.

TCF17_MOUSE
θ value	2.36792 (rank : 189)	NC score	0.007284 (rank : 611)
Query Neighborhood Hits	238	Target Neighborhood Hits	786	Shared Neighborhood Hits	34
SwissProt Accessions	Q61751	Gene names	Znf354a, Kid1, Tcf17, Zfp354a
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally- regulated protein 1).

CABP2_MOUSE
θ value	3.0926 (rank : 190)	NC score	0.159284 (rank : 104)
Query Neighborhood Hits	238	Target Neighborhood Hits	204	Shared Neighborhood Hits	101
SwissProt Accessions	Q9JLK4, Q9JLK5	Gene names	Cabp2
Domain Architecture
Description	Calcium-binding protein 2 (CaBP2).

CETN2_HUMAN
θ value	3.0926 (rank : 191)	NC score	0.170066 (rank : 93)
Query Neighborhood Hits	238	Target Neighborhood Hits	213	Shared Neighborhood Hits	104
SwissProt Accessions	P41208, Q53XW1	Gene names	CETN2, CALT, CEN2
Domain Architecture
Description	Centrin-2 (Caltractin isoform 1).

MCFD2_HUMAN
θ value	3.0926 (rank : 192)	NC score	0.127756 (rank : 138)
Query Neighborhood Hits	238	Target Neighborhood Hits	62	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NI22, Q8N3M5	Gene names	MCFD2, SDNSF
Domain Architecture
Description	Multiple coagulation factor deficiency protein 2 precursor (Neural stem cell-derived neuronal survival protein).

ZN248_HUMAN
θ value	3.0926 (rank : 193)	NC score	0.003797 (rank : 632)
Query Neighborhood Hits	238	Target Neighborhood Hits	749	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NDW4, Q9UMP3	Gene names	ZNF248
Domain Architecture
Description	Zinc finger protein 248.

ZN542_HUMAN
θ value	3.0926 (rank : 194)	NC score	0.005931 (rank : 623)
Query Neighborhood Hits	238	Target Neighborhood Hits	735	Shared Neighborhood Hits	33
SwissProt Accessions	Q5EBM4, Q6N061	Gene names	ZNF542
Domain Architecture	No domain graphic available
Description	Zinc finger protein 542.

ZN682_HUMAN
θ value	3.0926 (rank : 195)	NC score	0.006168 (rank : 621)
Query Neighborhood Hits	238	Target Neighborhood Hits	779	Shared Neighborhood Hits	39
SwissProt Accessions	O95780, Q96JV9	Gene names	ZNF682
Domain Architecture	No domain graphic available
Description	Zinc finger protein 682.

CABP5_HUMAN
θ value	4.03905 (rank : 196)	NC score	0.150717 (rank : 125)
Query Neighborhood Hits	238	Target Neighborhood Hits	197	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

CABP5_MOUSE
θ value	4.03905 (rank : 197)	NC score	0.151325 (rank : 123)
Query Neighborhood Hits	238	Target Neighborhood Hits	207	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

EFHB_HUMAN
θ value	4.03905 (rank : 198)	NC score	0.084396 (rank : 199)
Query Neighborhood Hits	238	Target Neighborhood Hits	125	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N7U6, Q6ZWK9, Q8IV58, Q96LQ6	Gene names	EFHB
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member B.

FSTL4_MOUSE
θ value	4.03905 (rank : 199)	NC score	0.021548 (rank : 592)
Query Neighborhood Hits	238	Target Neighborhood Hits	333	Shared Neighborhood Hits	13
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

PDCD6_HUMAN
θ value	4.03905 (rank : 200)	NC score	0.120162 (rank : 146)
Query Neighborhood Hits	238	Target Neighborhood Hits	141	Shared Neighborhood Hits	87
SwissProt Accessions	O75340	Gene names	PDCD6, ALG2
Domain Architecture
Description	Programmed cell death protein 6 (Probable calcium-binding protein ALG- 2).

PDCD6_MOUSE
θ value	4.03905 (rank : 201)	NC score	0.120432 (rank : 144)
Query Neighborhood Hits	238	Target Neighborhood Hits	142	Shared Neighborhood Hits	87
SwissProt Accessions	P12815, Q545I0, Q61145	Gene names	Pdcd6, Alg2
Domain Architecture
Description	Programmed cell death protein 6 (Probable calcium-binding protein ALG- 2) (PMP41) (ALG-257).

RGAP1_HUMAN
θ value	4.03905 (rank : 202)	NC score	0.061409 (rank : 355)
Query Neighborhood Hits	238	Target Neighborhood Hits	189	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RGNEF_MOUSE
θ value	4.03905 (rank : 203)	NC score	0.069309 (rank : 283)
Query Neighborhood Hits	238	Target Neighborhood Hits	641	Shared Neighborhood Hits	63
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ZN197_HUMAN
θ value	4.03905 (rank : 204)	NC score	0.008190 (rank : 606)
Query Neighborhood Hits	238	Target Neighborhood Hits	788	Shared Neighborhood Hits	33
SwissProt Accessions	O14709	Gene names	ZNF197, ZNF166
Domain Architecture
Description	Zinc finger protein 197 (ZnF20).

ZN334_HUMAN
θ value	4.03905 (rank : 205)	NC score	0.007287 (rank : 610)
Query Neighborhood Hits	238	Target Neighborhood Hits	778	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCZ1, Q5T6U2, Q9NVW4	Gene names	ZNF334
Domain Architecture
Description	Zinc finger protein 334.

ZN546_HUMAN
θ value	4.03905 (rank : 206)	NC score	0.007148 (rank : 614)
Query Neighborhood Hits	238	Target Neighborhood Hits	772	Shared Neighborhood Hits	33
SwissProt Accessions	Q86UE3	Gene names	ZNF546, ZNF49
Domain Architecture	No domain graphic available
Description	Zinc finger protein 546.

CABP2_HUMAN
θ value	5.27518 (rank : 207)	NC score	0.155047 (rank : 110)
Query Neighborhood Hits	238	Target Neighborhood Hits	205	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NPB3	Gene names	CABP2
Domain Architecture
Description	Calcium-binding protein 2 (CaBP2).

CALU_HUMAN
θ value	5.27518 (rank : 208)	NC score	0.054199 (rank : 496)
Query Neighborhood Hits	238	Target Neighborhood Hits	114	Shared Neighborhood Hits	64
SwissProt Accessions	O43852, O60456, Q6FHB9, Q96RL3, Q9NR43	Gene names	CALU
Domain Architecture
Description	Calumenin precursor (Crocalbin) (IEF SSP 9302).

CALU_MOUSE
θ value	5.27518 (rank : 209)	NC score	0.055381 (rank : 471)
Query Neighborhood Hits	238	Target Neighborhood Hits	113	Shared Neighborhood Hits	68
SwissProt Accessions	O35887	Gene names	Calu
Domain Architecture
Description	Calumenin precursor (Crocalbin).

DJBP_HUMAN
θ value	5.27518 (rank : 210)	NC score	0.041604 (rank : 587)
Query Neighborhood Hits	238	Target Neighborhood Hits	156	Shared Neighborhood Hits	50
SwissProt Accessions	Q5THR3, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5	Gene names	DJBP, KIAA1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein (CAP-binding protein complex-interacting protein 1).

MAGI2_HUMAN
θ value	5.27518 (rank : 211)	NC score	0.000524 (rank : 635)
Query Neighborhood Hits	238	Target Neighborhood Hits	373	Shared Neighborhood Hits	4
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MCFD2_MOUSE
θ value	5.27518 (rank : 212)	NC score	0.121259 (rank : 142)
Query Neighborhood Hits	238	Target Neighborhood Hits	61	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K5B2, Q3U9G5	Gene names	Mcfd2, Sdnsf
Domain Architecture
Description	Multiple coagulation factor deficiency protein 2 homolog precursor (Neural stem cell-derived neuronal survival protein).

PCSK5_MOUSE
θ value	5.27518 (rank : 213)	NC score	0.005485 (rank : 626)
Query Neighborhood Hits	238	Target Neighborhood Hits	613	Shared Neighborhood Hits	20
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

RASF5_HUMAN
θ value	5.27518 (rank : 214)	NC score	0.091193 (rank : 173)
Query Neighborhood Hits	238	Target Neighborhood Hits	79	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWW0, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99	Gene names	RASSF5, NORE1, RAPL
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

RGAP1_MOUSE
θ value	5.27518 (rank : 215)	NC score	0.064208 (rank : 303)
Query Neighborhood Hits	238	Target Neighborhood Hits	185	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

ZN506_HUMAN
θ value	5.27518 (rank : 216)	NC score	0.006198 (rank : 619)
Query Neighborhood Hits	238	Target Neighborhood Hits	743	Shared Neighborhood Hits	32
SwissProt Accessions	Q5JVG8	Gene names	ZNF506
Domain Architecture	No domain graphic available
Description	Zinc finger protein 506.

ARHG2_HUMAN
θ value	6.88961 (rank : 217)	NC score	0.053823 (rank : 503)
Query Neighborhood Hits	238	Target Neighborhood Hits	142	Shared Neighborhood Hits	32
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	6.88961 (rank : 218)	NC score	0.050497 (rank : 572)
Query Neighborhood Hits	238	Target Neighborhood Hits	120	Shared Neighborhood Hits	31
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

CERK1_MOUSE
θ value	6.88961 (rank : 219)	NC score	0.007695 (rank : 607)
Query Neighborhood Hits	238	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4Q7	Gene names	Cerk
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (mCERK).

CETN2_MOUSE
θ value	6.88961 (rank : 220)	NC score	0.169459 (rank : 94)
Query Neighborhood Hits	238	Target Neighborhood Hits	211	Shared Neighborhood Hits	104
SwissProt Accessions	Q9R1K9, Q3UBB4, Q9CWM0	Gene names	Cetn2, Calt
Domain Architecture
Description	Centrin-2 (Caltractin isoform 1).

LAMA5_MOUSE
θ value	6.88961 (rank : 221)	NC score	0.006264 (rank : 618)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	19
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

NTNG2_HUMAN
θ value	6.88961 (rank : 222)	NC score	0.014018 (rank : 595)
Query Neighborhood Hits	238	Target Neighborhood Hits	276	Shared Neighborhood Hits	13
SwissProt Accessions	Q96CW9, Q6UXY0, Q96JH0	Gene names	NTNG2, KIAA1857, LMNT2
Domain Architecture
Description	Netrin G2 precursor (Laminet-2).

NUCB1_HUMAN
θ value	6.88961 (rank : 223)	NC score	0.058302 (rank : 419)
Query Neighborhood Hits	238	Target Neighborhood Hits	359	Shared Neighborhood Hits	34
SwissProt Accessions	Q02818, Q15838, Q7Z4J7, Q9BUR1	Gene names	NUCB1, NUC
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

NUCB1_MOUSE
θ value	6.88961 (rank : 224)	NC score	0.059011 (rank : 406)
Query Neighborhood Hits	238	Target Neighborhood Hits	414	Shared Neighborhood Hits	36
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

PDZD8_HUMAN
θ value	6.88961 (rank : 225)	NC score	0.192945 (rank : 83)
Query Neighborhood Hits	238	Target Neighborhood Hits	185	Shared Neighborhood Hits	59
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PRVA_MOUSE
θ value	6.88961 (rank : 226)	NC score	0.120556 (rank : 143)
Query Neighborhood Hits	238	Target Neighborhood Hits	77	Shared Neighborhood Hits	60
SwissProt Accessions	P32848	Gene names	Pvalb, Pva
Domain Architecture
Description	Parvalbumin alpha.

RCN3_HUMAN
θ value	6.88961 (rank : 227)	NC score	0.051238 (rank : 554)
Query Neighborhood Hits	238	Target Neighborhood Hits	89	Shared Neighborhood Hits	63
SwissProt Accessions	Q96D15, Q9HBZ8	Gene names	RCN3
Domain Architecture
Description	Reticulocalbin-3 precursor (EF-hand calcium-binding protein RLP49).

TRI47_HUMAN
θ value	6.88961 (rank : 228)	NC score	0.005017 (rank : 628)
Query Neighborhood Hits	238	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

ZN181_HUMAN
θ value	6.88961 (rank : 229)	NC score	0.004293 (rank : 631)
Query Neighborhood Hits	238	Target Neighborhood Hits	764	Shared Neighborhood Hits	27
SwissProt Accessions	Q2M3W8, Q49A75	Gene names	ZNF181
Domain Architecture	No domain graphic available
Description	Zinc finger protein 181 (HHZ181).

ZN192_HUMAN
θ value	6.88961 (rank : 230)	NC score	0.004651 (rank : 630)
Query Neighborhood Hits	238	Target Neighborhood Hits	789	Shared Neighborhood Hits	32
SwissProt Accessions	Q15776, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1	Gene names	ZNF192
Domain Architecture
Description	Zinc finger protein 192 (LD5-1).

ZNF74_HUMAN
θ value	6.88961 (rank : 231)	NC score	0.005983 (rank : 622)
Query Neighborhood Hits	238	Target Neighborhood Hits	770	Shared Neighborhood Hits	35
SwissProt Accessions	Q16587, Q6IBV2, Q9UC04, Q9UF05, Q9UF06, Q9UF07	Gene names	ZNF74
Domain Architecture
Description	Zinc finger protein 74 (hZNF7).

LAMC1_MOUSE
θ value	8.99809 (rank : 232)	NC score	0.009907 (rank : 602)
Query Neighborhood Hits	238	Target Neighborhood Hits	856	Shared Neighborhood Hits	17
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

PLST_HUMAN
θ value	8.99809 (rank : 233)	NC score	0.081710 (rank : 211)
Query Neighborhood Hits	238	Target Neighborhood Hits	161	Shared Neighborhood Hits	79
SwissProt Accessions	P13797, Q86YI6	Gene names	PLS3
Domain Architecture
Description	Plastin-3 (T-plastin).

RCN3_MOUSE
θ value	8.99809 (rank : 234)	NC score	0.050601 (rank : 567)
Query Neighborhood Hits	238	Target Neighborhood Hits	91	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BH97, Q58E50, Q8R137, Q99K35, Q9CTD4	Gene names	Rcn3, D7Ertd671e
Domain Architecture	No domain graphic available
Description	Reticulocalbin-3 precursor.

SNCAP_HUMAN
θ value	8.99809 (rank : 235)	NC score	0.030044 (rank : 590)
Query Neighborhood Hits	238	Target Neighborhood Hits	313	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

SPHK2_HUMAN
θ value	8.99809 (rank : 236)	NC score	0.041369 (rank : 588)
Query Neighborhood Hits	238	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

ZN282_HUMAN
θ value	8.99809 (rank : 237)	NC score	0.002630 (rank : 633)
Query Neighborhood Hits	238	Target Neighborhood Hits	796	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UDV7, O43691, Q6DKK0	Gene names	ZNF282, HUB1
Domain Architecture
Description	Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1).

ZN600_HUMAN
θ value	8.99809 (rank : 238)	NC score	0.007072 (rank : 615)
Query Neighborhood Hits	238	Target Neighborhood Hits	774	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZNG1, Q6MZR0	Gene names	ZNF600
Domain Architecture	No domain graphic available
Description	Zinc finger protein 600.

AAPK1_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.061697 (rank : 349)
Query Neighborhood Hits	238	Target Neighborhood Hits	842	Shared Neighborhood Hits	35
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.062041 (rank : 345)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	35
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK2_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.062205 (rank : 342)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	36
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

AKT1_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.087753 (rank : 178)
Query Neighborhood Hits	238	Target Neighborhood Hits	885	Shared Neighborhood Hits	38
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.087566 (rank : 179)
Query Neighborhood Hits	238	Target Neighborhood Hits	878	Shared Neighborhood Hits	37
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

AKT2_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.085520 (rank : 191)
Query Neighborhood Hits	238	Target Neighborhood Hits	878	Shared Neighborhood Hits	36
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.085605 (rank : 188)
Query Neighborhood Hits	238	Target Neighborhood Hits	875	Shared Neighborhood Hits	36
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.085184 (rank : 195)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	θ > 10 (rank : 247)	NC score	0.085204 (rank : 193)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

ARBK1_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.083024 (rank : 205)
Query Neighborhood Hits	238	Target Neighborhood Hits	859	Shared Neighborhood Hits	37
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.083010 (rank : 206)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	37
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

ARBK2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.082642 (rank : 208)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

AURKB_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.063798 (rank : 307)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

AURKB_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.064383 (rank : 299)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.064290 (rank : 301)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

AURKC_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.064369 (rank : 300)
Query Neighborhood Hits	238	Target Neighborhood Hits	844	Shared Neighborhood Hits	35
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AYT1A_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.154633 (rank : 112)
Query Neighborhood Hits	238	Target Neighborhood Hits	126	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BYI6	Gene names	Aytl1a, Aytl1
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1-A (EC 2.3.1.-).

AYT1B_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.153044 (rank : 116)
Query Neighborhood Hits	238	Target Neighborhood Hits	113	Shared Neighborhood Hits	73
SwissProt Accessions	Q9D5U0	Gene names	Aytl1b
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1-B (EC 2.3.1.-).

AYTL1_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.164199 (rank : 100)
Query Neighborhood Hits	238	Target Neighborhood Hits	140	Shared Neighborhood Hits	89
SwissProt Accessions	Q7L5N7, Q6MZJ6, Q9NX23	Gene names	AYTL1
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1 (EC 2.3.1.-).

BRSK1_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.060403 (rank : 379)
Query Neighborhood Hits	238	Target Neighborhood Hits	942	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

BRSK2_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.059740 (rank : 391)
Query Neighborhood Hits	238	Target Neighborhood Hits	897	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

CAMKV_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.060365 (rank : 380)
Query Neighborhood Hits	238	Target Neighborhood Hits	1084	Shared Neighborhood Hits	37
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.060194 (rank : 383)
Query Neighborhood Hits	238	Target Neighborhood Hits	848	Shared Neighborhood Hits	36
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAYP1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.148679 (rank : 127)
Query Neighborhood Hits	238	Target Neighborhood Hits	94	Shared Neighborhood Hits	67
SwissProt Accessions	Q13938, Q3MJA7, Q8WUZ3	Gene names	CAPS
Domain Architecture
Description	Calcyphosin (Calcyphosine).

CDKL5_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.052867 (rank : 521)
Query Neighborhood Hits	238	Target Neighborhood Hits	967	Shared Neighborhood Hits	35
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

CHK1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.055024 (rank : 474)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	35
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.054650 (rank : 481)
Query Neighborhood Hits	238	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK2_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.060416 (rank : 377)
Query Neighborhood Hits	238	Target Neighborhood Hits	859	Shared Neighborhood Hits	35
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

CHK2_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.060406 (rank : 378)
Query Neighborhood Hits	238	Target Neighborhood Hits	860	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

CSKP_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.055128 (rank : 473)
Query Neighborhood Hits	238	Target Neighborhood Hits	1022	Shared Neighborhood Hits	38
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.055656 (rank : 464)
Query Neighborhood Hits	238	Target Neighborhood Hits	1027	Shared Neighborhood Hits	40
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

DAPK1_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.052111 (rank : 530)
Query Neighborhood Hits	238	Target Neighborhood Hits	1130	Shared Neighborhood Hits	39
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.053833 (rank : 502)
Query Neighborhood Hits	238	Target Neighborhood Hits	1138	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.057967 (rank : 428)
Query Neighborhood Hits	238	Target Neighborhood Hits	832	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK2_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.058827 (rank : 408)
Query Neighborhood Hits	238	Target Neighborhood Hits	834	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.057288 (rank : 442)
Query Neighborhood Hits	238	Target Neighborhood Hits	945	Shared Neighborhood Hits	35
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK3_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.056884 (rank : 445)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	35
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DCAK1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.057233 (rank : 444)
Query Neighborhood Hits	238	Target Neighborhood Hits	877	Shared Neighborhood Hits	35
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.057267 (rank : 443)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.059002 (rank : 407)
Query Neighborhood Hits	238	Target Neighborhood Hits	862	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK2_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.058438 (rank : 417)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK3_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.063276 (rank : 314)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	35
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

DCAK3_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.063023 (rank : 323)
Query Neighborhood Hits	238	Target Neighborhood Hits	922	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DMPK_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.091244 (rank : 172)
Query Neighborhood Hits	238	Target Neighborhood Hits	944	Shared Neighborhood Hits	35
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.091421 (rank : 171)
Query Neighborhood Hits	238	Target Neighborhood Hits	908	Shared Neighborhood Hits	35
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DUET_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.053762 (rank : 504)
Query Neighborhood Hits	238	Target Neighborhood Hits	1220	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DYR1A_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.055594 (rank : 467)
Query Neighborhood Hits	238	Target Neighborhood Hits	764	Shared Neighborhood Hits	35
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.055586 (rank : 468)
Query Neighborhood Hits	238	Target Neighborhood Hits	762	Shared Neighborhood Hits	35
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1B_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.054216 (rank : 494)
Query Neighborhood Hits	238	Target Neighborhood Hits	831	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

DYR1B_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.053380 (rank : 515)
Query Neighborhood Hits	238	Target Neighborhood Hits	799	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

DYRK2_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.052415 (rank : 524)
Query Neighborhood Hits	238	Target Neighborhood Hits	799	Shared Neighborhood Hits	35
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

E2AK2_HUMAN
θ value	θ > 10 (rank : 290)	NC score	0.051742 (rank : 541)
Query Neighborhood Hits	238	Target Neighborhood Hits	856	Shared Neighborhood Hits	35
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

E2AK2_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.055571 (rank : 469)
Query Neighborhood Hits	238	Target Neighborhood Hits	864	Shared Neighborhood Hits	35
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

E2AK4_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.050333 (rank : 580)
Query Neighborhood Hits	238	Target Neighborhood Hits	1012	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

E2AK4_MOUSE
θ value	θ > 10 (rank : 293)	NC score	0.051597 (rank : 547)
Query Neighborhood Hits	238	Target Neighborhood Hits	984	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

EFCB2_HUMAN
θ value	θ > 10 (rank : 294)	NC score	0.068887 (rank : 285)
Query Neighborhood Hits	238	Target Neighborhood Hits	73	Shared Neighborhood Hits	34
SwissProt Accessions	Q5VUJ9, Q59G23, Q9BS36	Gene names	EFCAB2
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 2.

EFCB2_MOUSE
θ value	θ > 10 (rank : 295)	NC score	0.072568 (rank : 276)
Query Neighborhood Hits	238	Target Neighborhood Hits	64	Shared Neighborhood Hits	32
SwissProt Accessions	Q9CQ46, Q9CS07	Gene names	Efcab2
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 2.

F5006_HUMAN
θ value	θ > 10 (rank : 296)	NC score	0.073335 (rank : 269)
Query Neighborhood Hits	238	Target Neighborhood Hits	794	Shared Neighborhood Hits	35
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

F5006_MOUSE
θ value	θ > 10 (rank : 297)	NC score	0.073132 (rank : 272)
Query Neighborhood Hits	238	Target Neighborhood Hits	793	Shared Neighborhood Hits	35
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

GMIP_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.051897 (rank : 535)
Query Neighborhood Hits	238	Target Neighborhood Hits	202	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GRK4_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.083199 (rank : 204)
Query Neighborhood Hits	238	Target Neighborhood Hits	822	Shared Neighborhood Hits	35
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

GRK4_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.083325 (rank : 203)
Query Neighborhood Hits	238	Target Neighborhood Hits	808	Shared Neighborhood Hits	35
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK5_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.081501 (rank : 212)
Query Neighborhood Hits	238	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK5_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.081407 (rank : 214)
Query Neighborhood Hits	238	Target Neighborhood Hits	823	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.080340 (rank : 222)
Query Neighborhood Hits	238	Target Neighborhood Hits	823	Shared Neighborhood Hits	37
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK6_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.080796 (rank : 220)
Query Neighborhood Hits	238	Target Neighborhood Hits	820	Shared Neighborhood Hits	35
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK7_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.082670 (rank : 207)
Query Neighborhood Hits	238	Target Neighborhood Hits	820	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

HIPK2_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.050905 (rank : 563)
Query Neighborhood Hits	238	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.050878 (rank : 564)
Query Neighborhood Hits	238	Target Neighborhood Hits	871	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

HUNK_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.063236 (rank : 317)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

HUNK_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.063060 (rank : 321)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

IKKA_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.054945 (rank : 477)
Query Neighborhood Hits	238	Target Neighborhood Hits	863	Shared Neighborhood Hits	35
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.054925 (rank : 478)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	35
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKB_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.054448 (rank : 487)
Query Neighborhood Hits	238	Target Neighborhood Hits	980	Shared Neighborhood Hits	37
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKB_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.054360 (rank : 489)
Query Neighborhood Hits	238	Target Neighborhood Hits	984	Shared Neighborhood Hits	35
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

IKKE_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.051649 (rank : 545)
Query Neighborhood Hits	238	Target Neighborhood Hits	837	Shared Neighborhood Hits	35
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IRAK1_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.050167 (rank : 582)
Query Neighborhood Hits	238	Target Neighborhood Hits	784	Shared Neighborhood Hits	36
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

K0999_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.059206 (rank : 402)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

K0999_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.059166 (rank : 404)
Query Neighborhood Hits	238	Target Neighborhood Hits	931	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KAPCA_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.079655 (rank : 227)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	θ > 10 (rank : 319)	NC score	0.079897 (rank : 225)
Query Neighborhood Hits	238	Target Neighborhood Hits	836	Shared Neighborhood Hits	35
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCB_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.080153 (rank : 224)
Query Neighborhood Hits	238	Target Neighborhood Hits	837	Shared Neighborhood Hits	35
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.080319 (rank : 223)
Query Neighborhood Hits	238	Target Neighborhood Hits	836	Shared Neighborhood Hits	35
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCG_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.077355 (rank : 240)
Query Neighborhood Hits	238	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KCC1A_HUMAN
θ value	θ > 10 (rank : 323)	NC score	0.062486 (rank : 334)
Query Neighborhood Hits	238	Target Neighborhood Hits	846	Shared Neighborhood Hits	35
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	θ > 10 (rank : 324)	NC score	0.062241 (rank : 340)
Query Neighborhood Hits	238	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1B_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.062876 (rank : 327)
Query Neighborhood Hits	238	Target Neighborhood Hits	842	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.062813 (rank : 329)
Query Neighborhood Hits	238	Target Neighborhood Hits	842	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1D_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.063959 (rank : 304)
Query Neighborhood Hits	238	Target Neighborhood Hits	846	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	θ > 10 (rank : 328)	NC score	0.063952 (rank : 305)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1G_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.062574 (rank : 333)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.062722 (rank : 330)
Query Neighborhood Hits	238	Target Neighborhood Hits	851	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2A_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.057599 (rank : 436)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.057746 (rank : 433)
Query Neighborhood Hits	238	Target Neighborhood Hits	829	Shared Neighborhood Hits	35
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.057513 (rank : 437)
Query Neighborhood Hits	238	Target Neighborhood Hits	866	Shared Neighborhood Hits	35
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.057301 (rank : 441)
Query Neighborhood Hits	238	Target Neighborhood Hits	841	Shared Neighborhood Hits	35
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2D_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.058062 (rank : 426)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KCC2G_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.058111 (rank : 423)
Query Neighborhood Hits	238	Target Neighborhood Hits	841	Shared Neighborhood Hits	35
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.058111 (rank : 422)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC4_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.062701 (rank : 331)
Query Neighborhood Hits	238	Target Neighborhood Hits	841	Shared Neighborhood Hits	35
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.062825 (rank : 328)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KGP1A_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.077352 (rank : 241)
Query Neighborhood Hits	238	Target Neighborhood Hits	901	Shared Neighborhood Hits	35
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.077274 (rank : 245)
Query Neighborhood Hits	238	Target Neighborhood Hits	921	Shared Neighborhood Hits	35
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.077295 (rank : 242)
Query Neighborhood Hits	238	Target Neighborhood Hits	922	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP2_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.074471 (rank : 258)
Query Neighborhood Hits	238	Target Neighborhood Hits	1023	Shared Neighborhood Hits	36
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_MOUSE
θ value	θ > 10 (rank : 344)	NC score	0.074800 (rank : 257)
Query Neighborhood Hits	238	Target Neighborhood Hits	1029	Shared Neighborhood Hits	37
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KKCC1_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.061592 (rank : 350)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC1_MOUSE
θ value	θ > 10 (rank : 346)	NC score	0.062305 (rank : 338)
Query Neighborhood Hits	238	Target Neighborhood Hits	866	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.059867 (rank : 389)
Query Neighborhood Hits	238	Target Neighborhood Hits	852	Shared Neighborhood Hits	35
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.059858 (rank : 390)
Query Neighborhood Hits	238	Target Neighborhood Hits	855	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPSH1_HUMAN
θ value	θ > 10 (rank : 349)	NC score	0.061383 (rank : 356)
Query Neighborhood Hits	238	Target Neighborhood Hits	842	Shared Neighborhood Hits	36
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	θ > 10 (rank : 350)	NC score	0.061224 (rank : 359)
Query Neighborhood Hits	238	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH2_HUMAN
θ value	θ > 10 (rank : 351)	NC score	0.063268 (rank : 315)
Query Neighborhood Hits	238	Target Neighborhood Hits	822	Shared Neighborhood Hits	35
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.073705 (rank : 263)
Query Neighborhood Hits	238	Target Neighborhood Hits	854	Shared Neighborhood Hits	35
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.073721 (rank : 262)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.073376 (rank : 268)
Query Neighborhood Hits	238	Target Neighborhood Hits	857	Shared Neighborhood Hits	35
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.073013 (rank : 274)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A3_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.073538 (rank : 267)
Query Neighborhood Hits	238	Target Neighborhood Hits	859	Shared Neighborhood Hits	35
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.073549 (rank : 266)
Query Neighborhood Hits	238	Target Neighborhood Hits	860	Shared Neighborhood Hits	35
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A4_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.080868 (rank : 218)
Query Neighborhood Hits	238	Target Neighborhood Hits	868	Shared Neighborhood Hits	35
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A4_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.080695 (rank : 221)
Query Neighborhood Hits	238	Target Neighborhood Hits	866	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

KS6A5_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.079293 (rank : 231)
Query Neighborhood Hits	238	Target Neighborhood Hits	855	Shared Neighborhood Hits	36
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6A5_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.082517 (rank : 209)
Query Neighborhood Hits	238	Target Neighborhood Hits	854	Shared Neighborhood Hits	36
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

KS6A6_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.074112 (rank : 260)
Query Neighborhood Hits	238	Target Neighborhood Hits	853	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KS6B1_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.080949 (rank : 216)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.080953 (rank : 215)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B2_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.080894 (rank : 217)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KS6B2_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.081473 (rank : 213)
Query Neighborhood Hits	238	Target Neighborhood Hits	871	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KS6C1_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.089366 (rank : 174)
Query Neighborhood Hits	238	Target Neighborhood Hits	682	Shared Neighborhood Hits	35
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KS6C1_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.091582 (rank : 170)
Query Neighborhood Hits	238	Target Neighborhood Hits	700	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KSR1_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.054912 (rank : 479)
Query Neighborhood Hits	238	Target Neighborhood Hits	870	Shared Neighborhood Hits	49
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

LATS1_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.085188 (rank : 194)
Query Neighborhood Hits	238	Target Neighborhood Hits	1057	Shared Neighborhood Hits	35
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LATS1_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.085282 (rank : 192)
Query Neighborhood Hits	238	Target Neighborhood Hits	1027	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

LATS2_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.084853 (rank : 197)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.085540 (rank : 190)
Query Neighborhood Hits	238	Target Neighborhood Hits	879	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

M3K11_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.053447 (rank : 514)
Query Neighborhood Hits	238	Target Neighborhood Hits	1136	Shared Neighborhood Hits	42
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

M3K14_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.060877 (rank : 361)
Query Neighborhood Hits	238	Target Neighborhood Hits	887	Shared Neighborhood Hits	35
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M3K14_MOUSE
θ value	θ > 10 (rank : 376)	NC score	0.060527 (rank : 374)
Query Neighborhood Hits	238	Target Neighborhood Hits	889	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

M3K15_HUMAN
θ value	θ > 10 (rank : 377)	NC score	0.053344 (rank : 516)
Query Neighborhood Hits	238	Target Neighborhood Hits	914	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K1_MOUSE
θ value	θ > 10 (rank : 378)	NC score	0.052707 (rank : 523)
Query Neighborhood Hits	238	Target Neighborhood Hits	952	Shared Neighborhood Hits	37
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K2_HUMAN
θ value	θ > 10 (rank : 379)	NC score	0.051972 (rank : 534)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K2_MOUSE
θ value	θ > 10 (rank : 380)	NC score	0.050580 (rank : 568)
Query Neighborhood Hits	238	Target Neighborhood Hits	846	Shared Neighborhood Hits	35
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	θ > 10 (rank : 381)	NC score	0.052138 (rank : 528)
Query Neighborhood Hits	238	Target Neighborhood Hits	885	Shared Neighborhood Hits	36
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K3_MOUSE
θ value	θ > 10 (rank : 382)	NC score	0.052284 (rank : 526)
Query Neighborhood Hits	238	Target Neighborhood Hits	876	Shared Neighborhood Hits	36
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M3K4_HUMAN
θ value	θ > 10 (rank : 383)	NC score	0.050809 (rank : 565)
Query Neighborhood Hits	238	Target Neighborhood Hits	911	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.050521 (rank : 570)
Query Neighborhood Hits	238	Target Neighborhood Hits	924	Shared Neighborhood Hits	35
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

M3K5_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.053050 (rank : 520)
Query Neighborhood Hits	238	Target Neighborhood Hits	868	Shared Neighborhood Hits	35
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	θ > 10 (rank : 386)	NC score	0.053117 (rank : 518)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	35
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K6_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.054609 (rank : 483)
Query Neighborhood Hits	238	Target Neighborhood Hits	889	Shared Neighborhood Hits	35
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M4K1_HUMAN
θ value	θ > 10 (rank : 388)	NC score	0.051663 (rank : 544)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K1_MOUSE
θ value	θ > 10 (rank : 389)	NC score	0.051111 (rank : 557)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

M4K2_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.054356 (rank : 490)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

M4K2_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.054219 (rank : 493)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	36
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K3_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.054968 (rank : 475)
Query Neighborhood Hits	238	Target Neighborhood Hits	857	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

M4K5_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.052174 (rank : 527)
Query Neighborhood Hits	238	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M4K5_MOUSE
θ value	θ > 10 (rank : 394)	NC score	0.052385 (rank : 525)
Query Neighborhood Hits	238	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MAPK2_HUMAN
θ value	θ > 10 (rank : 395)	NC score	0.059644 (rank : 392)
Query Neighborhood Hits	238	Target Neighborhood Hits	844	Shared Neighborhood Hits	35
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
θ value	θ > 10 (rank : 396)	NC score	0.059284 (rank : 397)
Query Neighborhood Hits	238	Target Neighborhood Hits	831	Shared Neighborhood Hits	35
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK3_HUMAN
θ value	θ > 10 (rank : 397)	NC score	0.059530 (rank : 394)
Query Neighborhood Hits	238	Target Neighborhood Hits	807	Shared Neighborhood Hits	35
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MAPK3_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.059372 (rank : 396)
Query Neighborhood Hits	238	Target Neighborhood Hits	811	Shared Neighborhood Hits	35
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAPK5_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.062366 (rank : 336)
Query Neighborhood Hits	238	Target Neighborhood Hits	795	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	θ > 10 (rank : 400)	NC score	0.062361 (rank : 337)
Query Neighborhood Hits	238	Target Neighborhood Hits	799	Shared Neighborhood Hits	35
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MARK1_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.060056 (rank : 387)
Query Neighborhood Hits	238	Target Neighborhood Hits	887	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK1_MOUSE
θ value	θ > 10 (rank : 402)	NC score	0.060266 (rank : 382)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK2_HUMAN
θ value	θ > 10 (rank : 403)	NC score	0.060092 (rank : 386)
Query Neighborhood Hits	238	Target Neighborhood Hits	1056	Shared Neighborhood Hits	36
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK2_MOUSE
θ value	θ > 10 (rank : 404)	NC score	0.060734 (rank : 368)
Query Neighborhood Hits	238	Target Neighborhood Hits	1018	Shared Neighborhood Hits	36
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK3_HUMAN
θ value	θ > 10 (rank : 405)	NC score	0.060500 (rank : 376)
Query Neighborhood Hits	238	Target Neighborhood Hits	893	Shared Neighborhood Hits	36
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MARK3_MOUSE
θ value	θ > 10 (rank : 406)	NC score	0.060123 (rank : 385)
Query Neighborhood Hits	238	Target Neighborhood Hits	919	Shared Neighborhood Hits	37
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK4_HUMAN
θ value	θ > 10 (rank : 407)	NC score	0.060924 (rank : 360)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	37
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	θ > 10 (rank : 408)	NC score	0.060673 (rank : 369)
Query Neighborhood Hits	238	Target Neighborhood Hits	898	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MAST1_HUMAN
θ value	θ > 10 (rank : 409)	NC score	0.079469 (rank : 229)
Query Neighborhood Hits	238	Target Neighborhood Hits	1146	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
θ value	θ > 10 (rank : 410)	NC score	0.079343 (rank : 230)
Query Neighborhood Hits	238	Target Neighborhood Hits	1123	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST2_HUMAN
θ value	θ > 10 (rank : 411)	NC score	0.077486 (rank : 238)
Query Neighborhood Hits	238	Target Neighborhood Hits	1189	Shared Neighborhood Hits	38
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST2_MOUSE
θ value	θ > 10 (rank : 412)	NC score	0.077527 (rank : 236)
Query Neighborhood Hits	238	Target Neighborhood Hits	1110	Shared Neighborhood Hits	37
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST3_HUMAN
θ value	θ > 10 (rank : 413)	NC score	0.078840 (rank : 232)
Query Neighborhood Hits	238	Target Neighborhood Hits	1128	Shared Neighborhood Hits	38
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MAST4_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.076371 (rank : 249)
Query Neighborhood Hits	238	Target Neighborhood Hits	1804	Shared Neighborhood Hits	40
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MASTL_HUMAN
θ value	θ > 10 (rank : 415)	NC score	0.077283 (rank : 243)
Query Neighborhood Hits	238	Target Neighborhood Hits	894	Shared Neighborhood Hits	35
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MASTL_MOUSE
θ value	θ > 10 (rank : 416)	NC score	0.076905 (rank : 246)
Query Neighborhood Hits	238	Target Neighborhood Hits	862	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MELK_HUMAN
θ value	θ > 10 (rank : 417)	NC score	0.061427 (rank : 354)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MELK_MOUSE
θ value	θ > 10 (rank : 418)	NC score	0.061435 (rank : 353)
Query Neighborhood Hits	238	Target Neighborhood Hits	860	Shared Neighborhood Hits	35
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MKNK1_HUMAN
θ value	θ > 10 (rank : 419)	NC score	0.066021 (rank : 295)
Query Neighborhood Hits	238	Target Neighborhood Hits	701	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK1_MOUSE
θ value	θ > 10 (rank : 420)	NC score	0.064539 (rank : 298)
Query Neighborhood Hits	238	Target Neighborhood Hits	811	Shared Neighborhood Hits	35
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK2_HUMAN
θ value	θ > 10 (rank : 421)	NC score	0.062982 (rank : 324)
Query Neighborhood Hits	238	Target Neighborhood Hits	821	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK2_MOUSE
θ value	θ > 10 (rank : 422)	NC score	0.063201 (rank : 318)
Query Neighborhood Hits	238	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MLE1_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.052004 (rank : 533)
Query Neighborhood Hits	238	Target Neighborhood Hits	64	Shared Neighborhood Hits	30
SwissProt Accessions	P05976	Gene names	MYL1
Domain Architecture
Description	Myosin light chain 1, skeletal muscle isoform (MLC1F) (A1 catalytic) (Alkali myosin light chain 1).

MLE1_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.050938 (rank : 561)
Query Neighborhood Hits	238	Target Neighborhood Hits	69	Shared Neighborhood Hits	30
SwissProt Accessions	P05977	Gene names	Myl1, Mylf
Domain Architecture
Description	Myosin light chain 1, skeletal muscle isoform (MLC1F) (A1 catalytic) (Alkali myosin light chain 1).

MLE3_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.051850 (rank : 536)
Query Neighborhood Hits	238	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	P06741	Gene names	MYL1
Domain Architecture
Description	Myosin light chain 3, skeletal muscle isoform (A2 catalytic) (Alkali myosin light chain 3) (MLC3F).

MLE3_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.050746 (rank : 566)
Query Neighborhood Hits	238	Target Neighborhood Hits	66	Shared Neighborhood Hits	29
SwissProt Accessions	P05978	Gene names	Myl1, Mylf
Domain Architecture
Description	Myosin light chain 3, skeletal muscle isoform (A2 catalytic) (Alkali myosin light chain 3) (MLC3F).

MLR5_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.062674 (rank : 332)
Query Neighborhood Hits	238	Target Neighborhood Hits	90	Shared Neighborhood Hits	51
SwissProt Accessions	Q02045	Gene names	MYL5
Domain Architecture
Description	Superfast myosin regulatory light chain 2 (MyLC-2) (MYLC2) (Myosin regulatory light chain 5).

MLRA_HUMAN
θ value	θ > 10 (rank : 428)	NC score	0.057335 (rank : 440)
Query Neighborhood Hits	238	Target Neighborhood Hits	91	Shared Neighborhood Hits	47
SwissProt Accessions	Q01449	Gene names	MYL7, MYLC2A
Domain Architecture
Description	Myosin regulatory light chain 2, atrial isoform (Myosin light chain 2a) (MLC-2a) (MLC2a) (Myosin regulatory light chain 7).

MLRA_MOUSE
θ value	θ > 10 (rank : 429)	NC score	0.061541 (rank : 351)
Query Neighborhood Hits	238	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QVP4, Q63977, Q9JIE8	Gene names	Myl7, Mylc2a
Domain Architecture
Description	Myosin regulatory light chain 2, atrial isoform (Myosin light chain 2a) (MLC-2a) (MLC2a) (Myosin regulatory light chain 7).

MLRM_HUMAN
θ value	θ > 10 (rank : 430)	NC score	0.078359 (rank : 234)
Query Neighborhood Hits	238	Target Neighborhood Hits	111	Shared Neighborhood Hits	61
SwissProt Accessions	P19105	Gene names	MRLC2, MLCB, RLC
Domain Architecture
Description	Myosin regulatory light chain 2, nonsarcomeric (Myosin RLC).

MLRN_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.079706 (rank : 226)
Query Neighborhood Hits	238	Target Neighborhood Hits	107	Shared Neighborhood Hits	59
SwissProt Accessions	P24844, Q9H136	Gene names	MYL9, MLC2, MRLC1, MYRL2
Domain Architecture
Description	Myosin regulatory light chain 2, smooth muscle isoform (Myosin RLC) (Myosin regulatory light chain 9) (LC20).

MLRN_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.078484 (rank : 233)
Query Neighborhood Hits	238	Target Neighborhood Hits	106	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CQ19, Q80X77	Gene names	Myl9, Myrl2
Domain Architecture
Description	Myosin regulatory light chain 2, smooth muscle isoform (Myosin RLC) (Myosin regulatory light chain 9).

MLRV_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.056168 (rank : 454)
Query Neighborhood Hits	238	Target Neighborhood Hits	89	Shared Neighborhood Hits	50
SwissProt Accessions	P10916, Q16123	Gene names	MYL2
Domain Architecture
Description	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v).

MLRV_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.055909 (rank : 459)
Query Neighborhood Hits	238	Target Neighborhood Hits	89	Shared Neighborhood Hits	49
SwissProt Accessions	P51667	Gene names	Myl2, Mylpc
Domain Architecture
Description	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v).

MLTK_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.050473 (rank : 574)
Query Neighborhood Hits	238	Target Neighborhood Hits	911	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.050449 (rank : 578)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MP2K1_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.054515 (rank : 485)
Query Neighborhood Hits	238	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.054511 (rank : 486)
Query Neighborhood Hits	238	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.054662 (rank : 480)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K2_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.054379 (rank : 488)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K3_MOUSE
θ value	θ > 10 (rank : 441)	NC score	0.051714 (rank : 542)
Query Neighborhood Hits	238	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K5_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.052067 (rank : 531)
Query Neighborhood Hits	238	Target Neighborhood Hits	837	Shared Neighborhood Hits	35
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K5_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.053934 (rank : 500)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

MP2K7_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.056065 (rank : 456)
Query Neighborhood Hits	238	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MST4_HUMAN
θ value	θ > 10 (rank : 445)	NC score	0.051755 (rank : 540)
Query Neighborhood Hits	238	Target Neighborhood Hits	852	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	θ > 10 (rank : 446)	NC score	0.051781 (rank : 539)
Query Neighborhood Hits	238	Target Neighborhood Hits	860	Shared Neighborhood Hits	35
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MYL3_MOUSE
θ value	θ > 10 (rank : 447)	NC score	0.051594 (rank : 548)
Query Neighborhood Hits	238	Target Neighborhood Hits	70	Shared Neighborhood Hits	30
SwissProt Accessions	P09542, Q3UIF4, Q9CQZ2	Gene names	Myl3, Mlc1v, Mylc
Domain Architecture
Description	Myosin light polypeptide 3 (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular/slow twitch myosin alkali light chain).

MYL6B_HUMAN
θ value	θ > 10 (rank : 448)	NC score	0.061541 (rank : 352)
Query Neighborhood Hits	238	Target Neighborhood Hits	78	Shared Neighborhood Hits	36
SwissProt Accessions	P14649	Gene names	MYL6B, MLC1SA
Domain Architecture
Description	Myosin light polypeptide 6B (Smooth muscle and nonmuscle myosin light chain alkali 6B) (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa).

MYL6B_MOUSE
θ value	θ > 10 (rank : 449)	NC score	0.056367 (rank : 449)
Query Neighborhood Hits	238	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CI43	Gene names	Myl6b
Domain Architecture	No domain graphic available
Description	Myosin light polypeptide 6B (Smooth muscle and nonmuscle myosin light chain alkali 6B).

MYL6_HUMAN
θ value	θ > 10 (rank : 450)	NC score	0.055820 (rank : 461)
Query Neighborhood Hits	238	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	P60660, P16475, P24572, P24573, Q12790, Q6IAZ0, Q6IPY5	Gene names	MYL6
Domain Architecture
Description	Myosin light polypeptide 6 (Smooth muscle and nonmuscle myosin light chain alkali 6) (Myosin light chain alkali 3) (Myosin light chain 3) (MLC-3) (LC17).

MYL6_MOUSE
θ value	θ > 10 (rank : 451)	NC score	0.055820 (rank : 462)
Query Neighborhood Hits	238	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	Q60605	Gene names	Myl6, Myln
Domain Architecture
Description	Myosin light polypeptide 6 (Smooth muscle and nonmuscle myosin light chain alkali 6) (Myosin light chain alkali 3) (Myosin light chain 3) (MLC-3) (LC17).

MYLK2_HUMAN
θ value	θ > 10 (rank : 452)	NC score	0.058745 (rank : 409)
Query Neighborhood Hits	238	Target Neighborhood Hits	920	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

MYLK_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.052793 (rank : 522)
Query Neighborhood Hits	238	Target Neighborhood Hits	1328	Shared Neighborhood Hits	39
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
θ value	θ > 10 (rank : 454)	NC score	0.053592 (rank : 510)
Query Neighborhood Hits	238	Target Neighborhood Hits	1489	Shared Neighborhood Hits	41
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYO3B_HUMAN
θ value	θ > 10 (rank : 455)	NC score	0.050548 (rank : 569)
Query Neighborhood Hits	238	Target Neighborhood Hits	923	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

NEK11_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.054238 (rank : 492)
Query Neighborhood Hits	238	Target Neighborhood Hits	1043	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.054201 (rank : 495)
Query Neighborhood Hits	238	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK1_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.054626 (rank : 482)
Query Neighborhood Hits	238	Target Neighborhood Hits	1129	Shared Neighborhood Hits	37
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.054020 (rank : 498)
Query Neighborhood Hits	238	Target Neighborhood Hits	1311	Shared Neighborhood Hits	35
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK2_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.053530 (rank : 513)
Query Neighborhood Hits	238	Target Neighborhood Hits	908	Shared Neighborhood Hits	35
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	θ > 10 (rank : 461)	NC score	0.054947 (rank : 476)
Query Neighborhood Hits	238	Target Neighborhood Hits	876	Shared Neighborhood Hits	35
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK3_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.059283 (rank : 398)
Query Neighborhood Hits	238	Target Neighborhood Hits	865	Shared Neighborhood Hits	35
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	θ > 10 (rank : 463)	NC score	0.060592 (rank : 372)
Query Neighborhood Hits	238	Target Neighborhood Hits	854	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.056365 (rank : 450)
Query Neighborhood Hits	238	Target Neighborhood Hits	883	Shared Neighborhood Hits	35
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK4_MOUSE
θ value	θ > 10 (rank : 465)	NC score	0.056204 (rank : 452)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK8_HUMAN
θ value	θ > 10 (rank : 466)	NC score	0.051246 (rank : 552)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	θ > 10 (rank : 467)	NC score	0.051179 (rank : 555)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	θ > 10 (rank : 468)	NC score	0.053949 (rank : 499)
Query Neighborhood Hits	238	Target Neighborhood Hits	900	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	θ > 10 (rank : 469)	NC score	0.054524 (rank : 484)
Query Neighborhood Hits	238	Target Neighborhood Hits	890	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NIM1_HUMAN
θ value	θ > 10 (rank : 470)	NC score	0.061893 (rank : 347)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NIM1_MOUSE
θ value	θ > 10 (rank : 471)	NC score	0.061378 (rank : 357)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

NRK_MOUSE
θ value	θ > 10 (rank : 472)	NC score	0.050453 (rank : 577)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NUAK1_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.060656 (rank : 370)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.060655 (rank : 371)
Query Neighborhood Hits	238	Target Neighborhood Hits	881	Shared Neighborhood Hits	35
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.062260 (rank : 339)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK2_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.063850 (rank : 306)
Query Neighborhood Hits	238	Target Neighborhood Hits	878	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

OXSR1_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.050163 (rank : 583)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
θ value	θ > 10 (rank : 478)	NC score	0.050507 (rank : 571)
Query Neighborhood Hits	238	Target Neighborhood Hits	865	Shared Neighborhood Hits	36
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK1_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.053535 (rank : 512)
Query Neighborhood Hits	238	Target Neighborhood Hits	873	Shared Neighborhood Hits	35
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.053655 (rank : 509)
Query Neighborhood Hits	238	Target Neighborhood Hits	878	Shared Neighborhood Hits	35
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK2_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.053870 (rank : 501)
Query Neighborhood Hits	238	Target Neighborhood Hits	862	Shared Neighborhood Hits	35
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	θ > 10 (rank : 482)	NC score	0.053759 (rank : 505)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK3_HUMAN
θ value	θ > 10 (rank : 483)	NC score	0.053559 (rank : 511)
Query Neighborhood Hits	238	Target Neighborhood Hits	887	Shared Neighborhood Hits	36
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.053718 (rank : 507)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	36
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

PAK4_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.056091 (rank : 455)
Query Neighborhood Hits	238	Target Neighborhood Hits	924	Shared Neighborhood Hits	35
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK4_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.056182 (rank : 453)
Query Neighborhood Hits	238	Target Neighborhood Hits	1098	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PAK6_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.054311 (rank : 491)
Query Neighborhood Hits	238	Target Neighborhood Hits	915	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

PAK7_HUMAN
θ value	θ > 10 (rank : 488)	NC score	0.055604 (rank : 466)
Query Neighborhood Hits	238	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	θ > 10 (rank : 489)	NC score	0.055182 (rank : 472)
Query Neighborhood Hits	238	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PASK_HUMAN
θ value	θ > 10 (rank : 490)	NC score	0.060807 (rank : 364)
Query Neighborhood Hits	238	Target Neighborhood Hits	857	Shared Neighborhood Hits	35
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PASK_MOUSE
θ value	θ > 10 (rank : 491)	NC score	0.060762 (rank : 366)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PCAT1_HUMAN
θ value	θ > 10 (rank : 492)	NC score	0.102026 (rank : 158)
Query Neighborhood Hits	238	Target Neighborhood Hits	80	Shared Neighborhood Hits	59
SwissProt Accessions	Q8NF37, Q1HAQ1, Q7Z4G6, Q8N3U7, Q8WUL8, Q9GZW6	Gene names	AYTL2, LPCAT1, PFAAP3
Domain Architecture	No domain graphic available
Description	1-acylglycerophosphocholine O-acyltransferase 1 (EC 2.3.1.23) (Lung- type acyl-coa:lysophosphatidylcholine acyltransferase 1) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3).

PCAT1_MOUSE
θ value	θ > 10 (rank : 493)	NC score	0.099104 (rank : 159)
Query Neighborhood Hits	238	Target Neighborhood Hits	78	Shared Neighborhood Hits	59
SwissProt Accessions	Q3TFD2, Q3TAX4, Q6NXZ6, Q8BG23, Q8BUX7, Q99JU6	Gene names	Aytl2, Lpcat1
Domain Architecture	No domain graphic available
Description	1-acylglycerophosphocholine O-acyltransferase 1 (EC 2.3.1.23) (Lung- type acyl-coa:lysophosphatidylcholine acyltransferase 1) (mLPCAT1) (Acyltransferase-like 2).

PDK1L_HUMAN
θ value	θ > 10 (rank : 494)	NC score	0.058200 (rank : 421)
Query Neighborhood Hits	238	Target Neighborhood Hits	821	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	θ > 10 (rank : 495)	NC score	0.058050 (rank : 427)
Query Neighborhood Hits	238	Target Neighborhood Hits	821	Shared Neighborhood Hits	35
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDPK1_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.073077 (rank : 273)
Query Neighborhood Hits	238	Target Neighborhood Hits	851	Shared Neighborhood Hits	35
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.073260 (rank : 271)
Query Neighborhood Hits	238	Target Neighborhood Hits	852	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PHKG1_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.059158 (rank : 405)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG1_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.060135 (rank : 384)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_HUMAN
θ value	θ > 10 (rank : 500)	NC score	0.058713 (rank : 411)
Query Neighborhood Hits	238	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

PHKG2_MOUSE
θ value	θ > 10 (rank : 501)	NC score	0.058572 (rank : 414)
Query Neighborhood Hits	238	Target Neighborhood Hits	841	Shared Neighborhood Hits	35
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PIM1_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.057890 (rank : 430)
Query Neighborhood Hits	238	Target Neighborhood Hits	797	Shared Neighborhood Hits	35
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM1_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.059238 (rank : 401)
Query Neighborhood Hits	238	Target Neighborhood Hits	787	Shared Neighborhood Hits	35
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM2_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.062208 (rank : 341)
Query Neighborhood Hits	238	Target Neighborhood Hits	808	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

PIM2_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.063414 (rank : 311)
Query Neighborhood Hits	238	Target Neighborhood Hits	809	Shared Neighborhood Hits	35
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PIM3_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.061374 (rank : 358)
Query Neighborhood Hits	238	Target Neighborhood Hits	789	Shared Neighborhood Hits	35
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PIM3_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.061756 (rank : 348)
Query Neighborhood Hits	238	Target Neighborhood Hits	783	Shared Neighborhood Hits	35
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PINK1_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.057860 (rank : 431)
Query Neighborhood Hits	238	Target Neighborhood Hits	741	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PINK1_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.063467 (rank : 308)
Query Neighborhood Hits	238	Target Neighborhood Hits	726	Shared Neighborhood Hits	35
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PKN1_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.087915 (rank : 176)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN1_MOUSE
θ value	θ > 10 (rank : 511)	NC score	0.088026 (rank : 175)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	35
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN2_HUMAN
θ value	θ > 10 (rank : 512)	NC score	0.087373 (rank : 180)
Query Neighborhood Hits	238	Target Neighborhood Hits	892	Shared Neighborhood Hits	35
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	θ > 10 (rank : 513)	NC score	0.087197 (rank : 181)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN3_HUMAN
θ value	θ > 10 (rank : 514)	NC score	0.087798 (rank : 177)
Query Neighborhood Hits	238	Target Neighborhood Hits	893	Shared Neighborhood Hits	36
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_MOUSE
θ value	θ > 10 (rank : 515)	NC score	0.086263 (rank : 183)
Query Neighborhood Hits	238	Target Neighborhood Hits	1009	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PLK1_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.063047 (rank : 322)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK1_MOUSE
θ value	θ > 10 (rank : 517)	NC score	0.063148 (rank : 319)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK2_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.060508 (rank : 375)
Query Neighborhood Hits	238	Target Neighborhood Hits	854	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	θ > 10 (rank : 519)	NC score	0.060311 (rank : 381)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	θ > 10 (rank : 520)	NC score	0.059267 (rank : 399)
Query Neighborhood Hits	238	Target Neighborhood Hits	865	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

PLK3_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.058631 (rank : 413)
Query Neighborhood Hits	238	Target Neighborhood Hits	863	Shared Neighborhood Hits	35
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PLK4_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.060751 (rank : 367)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK4_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.060862 (rank : 362)
Query Neighborhood Hits	238	Target Neighborhood Hits	879	Shared Neighborhood Hits	35
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLSI_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.109111 (rank : 155)
Query Neighborhood Hits	238	Target Neighborhood Hits	209	Shared Neighborhood Hits	98
SwissProt Accessions	Q14651	Gene names	PLS1
Domain Architecture
Description	Plastin-1 (I-plastin) (Intestine-specific plastin).

PLST_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.072436 (rank : 277)
Query Neighborhood Hits	238	Target Neighborhood Hits	156	Shared Neighborhood Hits	78
SwissProt Accessions	Q99K51	Gene names	Pls3
Domain Architecture	No domain graphic available
Description	Plastin-3 (T-plastin).

PMYT1_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.060830 (rank : 363)
Query Neighborhood Hits	238	Target Neighborhood Hits	814	Shared Neighborhood Hits	35
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PMYT1_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.059995 (rank : 388)
Query Neighborhood Hits	238	Target Neighborhood Hits	910	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PPE1_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.051325 (rank : 550)
Query Neighborhood Hits	238	Target Neighborhood Hits	137	Shared Neighborhood Hits	73
SwissProt Accessions	O14829, O15253, Q9NU21, Q9UJH0	Gene names	PPEF1, PPEF, PPP7C
Domain Architecture
Description	Serine/threonine-protein phosphatase with EF-hands 1 (EC 3.1.3.16) (PPEF-1) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine-protein phosphatase 7) (PP7).

PRKX_HUMAN
θ value	θ > 10 (rank : 529)	NC score	0.077281 (rank : 244)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PRKX_MOUSE
θ value	θ > 10 (rank : 530)	NC score	0.077427 (rank : 239)
Query Neighborhood Hits	238	Target Neighborhood Hits	846	Shared Neighborhood Hits	35
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

PRKY_HUMAN
θ value	θ > 10 (rank : 531)	NC score	0.072845 (rank : 275)
Query Neighborhood Hits	238	Target Neighborhood Hits	844	Shared Neighborhood Hits	35
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PRVA_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.108645 (rank : 156)
Query Neighborhood Hits	238	Target Neighborhood Hits	63	Shared Neighborhood Hits	56
SwissProt Accessions	P20472, P78378, Q4VB78, Q5R3Q9	Gene names	PVALB
Domain Architecture	No domain graphic available
Description	Parvalbumin alpha.

PXK_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.055858 (rank : 460)
Query Neighborhood Hits	238	Target Neighborhood Hits	216	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 534)	NC score	0.053075 (rank : 519)
Query Neighborhood Hits	238	Target Neighborhood Hits	320	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RCN2_HUMAN
θ value	θ > 10 (rank : 535)	NC score	0.062912 (rank : 326)
Query Neighborhood Hits	238	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q14257	Gene names	RCN2, ERC55
Domain Architecture
Description	Reticulocalbin-2 precursor (Calcium-binding protein ERC-55) (E6- binding protein) (E6BP).

RCN2_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.075906 (rank : 254)
Query Neighborhood Hits	238	Target Neighborhood Hits	108	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BP92, O70341	Gene names	Rcn2
Domain Architecture	No domain graphic available
Description	Reticulocalbin-2 precursor (Taipoxin-associated calcium-binding protein 49) (TCBP-49).

RIPK2_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.050468 (rank : 576)
Query Neighborhood Hits	238	Target Neighborhood Hits	776	Shared Neighborhood Hits	35
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK3_HUMAN
θ value	θ > 10 (rank : 538)	NC score	0.051692 (rank : 543)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 539)	NC score	0.053322 (rank : 517)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RIPK5_HUMAN
θ value	θ > 10 (rank : 540)	NC score	0.059497 (rank : 395)
Query Neighborhood Hits	238	Target Neighborhood Hits	864	Shared Neighborhood Hits	35
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	θ > 10 (rank : 541)	NC score	0.059622 (rank : 393)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RK_HUMAN
θ value	θ > 10 (rank : 542)	NC score	0.082285 (rank : 210)
Query Neighborhood Hits	238	Target Neighborhood Hits	835	Shared Neighborhood Hits	35
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

RK_MOUSE
θ value	θ > 10 (rank : 543)	NC score	0.079625 (rank : 228)
Query Neighborhood Hits	238	Target Neighborhood Hits	829	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ROCK1_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.073270 (rank : 270)
Query Neighborhood Hits	238	Target Neighborhood Hits	2000	Shared Neighborhood Hits	52
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.071407 (rank : 279)
Query Neighborhood Hits	238	Target Neighborhood Hits	2126	Shared Neighborhood Hits	52
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

ROCK2_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.073801 (rank : 261)
Query Neighborhood Hits	238	Target Neighborhood Hits	2073	Shared Neighborhood Hits	53
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

ROCK2_MOUSE
θ value	θ > 10 (rank : 547)	NC score	0.073606 (rank : 265)
Query Neighborhood Hits	238	Target Neighborhood Hits	2072	Shared Neighborhood Hits	51
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

RPKL1_HUMAN
θ value	θ > 10 (rank : 548)	NC score	0.095652 (rank : 162)
Query Neighborhood Hits	238	Target Neighborhood Hits	708	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
θ value	θ > 10 (rank : 549)	NC score	0.095602 (rank : 163)
Query Neighborhood Hits	238	Target Neighborhood Hits	704	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

SBK1_HUMAN
θ value	θ > 10 (rank : 550)	NC score	0.063433 (rank : 309)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_MOUSE
θ value	θ > 10 (rank : 551)	NC score	0.062917 (rank : 325)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	35
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SCYL2_HUMAN
θ value	θ > 10 (rank : 552)	NC score	0.050935 (rank : 562)
Query Neighborhood Hits	238	Target Neighborhood Hits	632	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SCYL2_MOUSE
θ value	θ > 10 (rank : 553)	NC score	0.052032 (rank : 532)
Query Neighborhood Hits	238	Target Neighborhood Hits	603	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SGK1_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.085592 (rank : 189)
Query Neighborhood Hits	238	Target Neighborhood Hits	848	Shared Neighborhood Hits	35
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
θ value	θ > 10 (rank : 555)	NC score	0.085841 (rank : 186)
Query Neighborhood Hits	238	Target Neighborhood Hits	848	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_HUMAN
θ value	θ > 10 (rank : 556)	NC score	0.086917 (rank : 182)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK2_MOUSE
θ value	θ > 10 (rank : 557)	NC score	0.086129 (rank : 184)
Query Neighborhood Hits	238	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK3_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.085921 (rank : 185)
Query Neighborhood Hits	238	Target Neighborhood Hits	877	Shared Neighborhood Hits	35
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
θ value	θ > 10 (rank : 559)	NC score	0.085660 (rank : 187)
Query Neighborhood Hits	238	Target Neighborhood Hits	882	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

SN1L1_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.058680 (rank : 412)
Query Neighborhood Hits	238	Target Neighborhood Hits	911	Shared Neighborhood Hits	37
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

SN1L1_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.057613 (rank : 435)
Query Neighborhood Hits	238	Target Neighborhood Hits	895	Shared Neighborhood Hits	36
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

SN1L2_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.058103 (rank : 425)
Query Neighborhood Hits	238	Target Neighborhood Hits	964	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	θ > 10 (rank : 563)	NC score	0.058545 (rank : 416)
Query Neighborhood Hits	238	Target Neighborhood Hits	944	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

SNRK_HUMAN
θ value	θ > 10 (rank : 564)	NC score	0.058570 (rank : 415)
Query Neighborhood Hits	238	Target Neighborhood Hits	855	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_MOUSE
θ value	θ > 10 (rank : 565)	NC score	0.057655 (rank : 434)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SPEG_HUMAN
θ value	θ > 10 (rank : 566)	NC score	0.050301 (rank : 581)
Query Neighborhood Hits	238	Target Neighborhood Hits	1762	Shared Neighborhood Hits	41
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

ST17A_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.064288 (rank : 302)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	θ > 10 (rank : 568)	NC score	0.063421 (rank : 310)
Query Neighborhood Hits	238	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.062109 (rank : 343)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST32A_HUMAN
θ value	θ > 10 (rank : 570)	NC score	0.075374 (rank : 255)
Query Neighborhood Hits	238	Target Neighborhood Hits	834	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

ST32A_MOUSE
θ value	θ > 10 (rank : 571)	NC score	0.074367 (rank : 259)
Query Neighborhood Hits	238	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

ST32B_HUMAN
θ value	θ > 10 (rank : 572)	NC score	0.076641 (rank : 247)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

ST32B_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.076096 (rank : 252)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

ST32C_HUMAN
θ value	θ > 10 (rank : 574)	NC score	0.077941 (rank : 235)
Query Neighborhood Hits	238	Target Neighborhood Hits	832	Shared Neighborhood Hits	35
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	θ > 10 (rank : 575)	NC score	0.077495 (rank : 237)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	35
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

ST38L_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.084303 (rank : 200)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ST38L_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.085029 (rank : 196)
Query Neighborhood Hits	238	Target Neighborhood Hits	821	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK11_HUMAN
θ value	θ > 10 (rank : 578)	NC score	0.058417 (rank : 418)
Query Neighborhood Hits	238	Target Neighborhood Hits	831	Shared Neighborhood Hits	35
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

STK24_HUMAN
θ value	θ > 10 (rank : 579)	NC score	0.051137 (rank : 556)
Query Neighborhood Hits	238	Target Neighborhood Hits	853	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK24_MOUSE
θ value	θ > 10 (rank : 580)	NC score	0.051293 (rank : 551)
Query Neighborhood Hits	238	Target Neighborhood Hits	856	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK25_HUMAN
θ value	θ > 10 (rank : 581)	NC score	0.051810 (rank : 537)
Query Neighborhood Hits	238	Target Neighborhood Hits	853	Shared Neighborhood Hits	35
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
θ value	θ > 10 (rank : 582)	NC score	0.051782 (rank : 538)
Query Neighborhood Hits	238	Target Neighborhood Hits	851	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK33_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.060803 (rank : 365)
Query Neighborhood Hits	238	Target Neighborhood Hits	879	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

STK35_HUMAN
θ value	θ > 10 (rank : 584)	NC score	0.053733 (rank : 506)
Query Neighborhood Hits	238	Target Neighborhood Hits	825	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

STK36_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.057799 (rank : 432)
Query Neighborhood Hits	238	Target Neighborhood Hits	896	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.057496 (rank : 438)
Query Neighborhood Hits	238	Target Neighborhood Hits	877	Shared Neighborhood Hits	35
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK38_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.084092 (rank : 201)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.084023 (rank : 202)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK39_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.050471 (rank : 575)
Query Neighborhood Hits	238	Target Neighborhood Hits	882	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.050403 (rank : 579)
Query Neighborhood Hits	238	Target Neighborhood Hits	915	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

STK40_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.070555 (rank : 281)
Query Neighborhood Hits	238	Target Neighborhood Hits	751	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.070794 (rank : 280)
Query Neighborhood Hits	238	Target Neighborhood Hits	751	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STK6_HUMAN
θ value	θ > 10 (rank : 593)	NC score	0.062071 (rank : 344)
Query Neighborhood Hits	238	Target Neighborhood Hits	916	Shared Neighborhood Hits	36
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

STK6_MOUSE
θ value	θ > 10 (rank : 594)	NC score	0.061975 (rank : 346)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

TBK1_HUMAN
θ value	θ > 10 (rank : 595)	NC score	0.055719 (rank : 463)
Query Neighborhood Hits	238	Target Neighborhood Hits	861	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
θ value	θ > 10 (rank : 596)	NC score	0.056029 (rank : 457)
Query Neighborhood Hits	238	Target Neighborhood Hits	893	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TLK1_HUMAN
θ value	θ > 10 (rank : 597)	NC score	0.051013 (rank : 559)
Query Neighborhood Hits	238	Target Neighborhood Hits	967	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	θ > 10 (rank : 598)	NC score	0.051069 (rank : 558)
Query Neighborhood Hits	238	Target Neighborhood Hits	947	Shared Neighborhood Hits	37
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK2_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.050490 (rank : 573)
Query Neighborhood Hits	238	Target Neighborhood Hits	1044	Shared Neighborhood Hits	36
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.050108 (rank : 584)
Query Neighborhood Hits	238	Target Neighborhood Hits	1088	Shared Neighborhood Hits	36
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

TRIB1_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.068290 (rank : 289)
Query Neighborhood Hits	238	Target Neighborhood Hits	598	Shared Neighborhood Hits	34
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
θ value	θ > 10 (rank : 602)	NC score	0.067444 (rank : 292)
Query Neighborhood Hits	238	Target Neighborhood Hits	593	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

TRIB2_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.064871 (rank : 296)
Query Neighborhood Hits	238	Target Neighborhood Hits	657	Shared Neighborhood Hits	35
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	θ > 10 (rank : 604)	NC score	0.064765 (rank : 297)
Query Neighborhood Hits	238	Target Neighborhood Hits	653	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB3_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.069775 (rank : 282)
Query Neighborhood Hits	238	Target Neighborhood Hits	519	Shared Neighborhood Hits	30
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

TRIB3_MOUSE
θ value	θ > 10 (rank : 606)	NC score	0.067660 (rank : 291)
Query Neighborhood Hits	238	Target Neighborhood Hits	578	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TRIO_HUMAN
θ value	θ > 10 (rank : 607)	NC score	0.055609 (rank : 465)
Query Neighborhood Hits	238	Target Neighborhood Hits	1580	Shared Neighborhood Hits	48
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TSSK1_HUMAN
θ value	θ > 10 (rank : 608)	NC score	0.063291 (rank : 313)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK1_MOUSE
θ value	θ > 10 (rank : 609)	NC score	0.059245 (rank : 400)
Query Neighborhood Hits	238	Target Neighborhood Hits	835	Shared Neighborhood Hits	35
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
θ value	θ > 10 (rank : 610)	NC score	0.062436 (rank : 335)
Query Neighborhood Hits	238	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

TSSK2_MOUSE
θ value	θ > 10 (rank : 611)	NC score	0.063236 (rank : 316)
Query Neighborhood Hits	238	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK3_HUMAN
θ value	θ > 10 (rank : 612)	NC score	0.055980 (rank : 458)
Query Neighborhood Hits	238	Target Neighborhood Hits	806	Shared Neighborhood Hits	35
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK3_MOUSE
θ value	θ > 10 (rank : 613)	NC score	0.056457 (rank : 448)
Query Neighborhood Hits	238	Target Neighborhood Hits	806	Shared Neighborhood Hits	35
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

TSSK4_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.063123 (rank : 320)
Query Neighborhood Hits	238	Target Neighborhood Hits	836	Shared Neighborhood Hits	35
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

TSSK4_MOUSE
θ value	θ > 10 (rank : 615)	NC score	0.063327 (rank : 312)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK6_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.059177 (rank : 403)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK6_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.058232 (rank : 420)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	35
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TTK_HUMAN
θ value	θ > 10 (rank : 618)	NC score	0.053676 (rank : 508)
Query Neighborhood Hits	238	Target Neighborhood Hits	816	Shared Neighborhood Hits	35
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

TTK_MOUSE
θ value	θ > 10 (rank : 619)	NC score	0.054147 (rank : 497)
Query Neighborhood Hits	238	Target Neighborhood Hits	803	Shared Neighborhood Hits	35
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

ULK1_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.056503 (rank : 447)
Query Neighborhood Hits	238	Target Neighborhood Hits	1121	Shared Neighborhood Hits	36
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.056359 (rank : 451)
Query Neighborhood Hits	238	Target Neighborhood Hits	1214	Shared Neighborhood Hits	38
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ULK2_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.056812 (rank : 446)
Query Neighborhood Hits	238	Target Neighborhood Hits	979	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.057432 (rank : 439)
Query Neighborhood Hits	238	Target Neighborhood Hits	943	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

ULK3_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.058106 (rank : 424)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK3_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.058743 (rank : 410)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

ULK4_MOUSE
θ value	θ > 10 (rank : 626)	NC score	0.068818 (rank : 286)
Query Neighborhood Hits	238	Target Neighborhood Hits	793	Shared Neighborhood Hits	35
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

VAV3_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.076274 (rank : 250)
Query Neighborhood Hits	238	Target Neighborhood Hits	398	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 628)	NC score	0.076148 (rank : 251)
Query Neighborhood Hits	238	Target Neighborhood Hits	404	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.084797 (rank : 198)
Query Neighborhood Hits	238	Target Neighborhood Hits	452	Shared Neighborhood Hits	63
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 630)	NC score	0.080802 (rank : 219)
Query Neighborhood Hits	238	Target Neighborhood Hits	430	Shared Neighborhood Hits	61
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

WNK1_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.051624 (rank : 546)
Query Neighborhood Hits	238	Target Neighborhood Hits	1158	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 632)	NC score	0.051245 (rank : 553)
Query Neighborhood Hits	238	Target Neighborhood Hits	1179	Shared Neighborhood Hits	36
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK3_HUMAN
θ value	θ > 10 (rank : 633)	NC score	0.052118 (rank : 529)
Query Neighborhood Hits	238	Target Neighborhood Hits	948	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

WNK4_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.050961 (rank : 560)
Query Neighborhood Hits	238	Target Neighborhood Hits	1043	Shared Neighborhood Hits	35
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK4_MOUSE
θ value	θ > 10 (rank : 635)	NC score	0.051434 (rank : 549)
Query Neighborhood Hits	238	Target Neighborhood Hits	961	Shared Neighborhood Hits	35
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

Hits sorted by NC score

DGKB_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	238	Target Neighborhood Hits	238	Shared Neighborhood Hits	238
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKG_MOUSE
NC score	0.979174 (rank : 2)	θ value	0 (rank : 5)
Query Neighborhood Hits	238	Target Neighborhood Hits	188	Shared Neighborhood Hits	144
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

DGKG_HUMAN
NC score	0.977427 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	238	Target Neighborhood Hits	171	Shared Neighborhood Hits	139
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

DGKA_MOUSE
NC score	0.960040 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	238	Target Neighborhood Hits	146	Shared Neighborhood Hits	124
SwissProt Accessions	O88673, Q922X2	Gene names	Dgka, Dagk1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

DGKA_HUMAN
NC score	0.959154 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	238	Target Neighborhood Hits	151	Shared Neighborhood Hits	123
SwissProt Accessions	P23743, O75481, O75482, O75483	Gene names	DGKA, DAGK, DAGK1
Domain Architecture
Description	Diacylglycerol kinase alpha (EC 2.7.1.107) (Diglyceride kinase alpha) (DGK-alpha) (DAG kinase alpha) (80 kDa diacylglycerol kinase).

DGKQ_HUMAN
NC score	0.873193 (rank : 6)	θ value	2.24614e-67 (rank : 11)
Query Neighborhood Hits	238	Target Neighborhood Hits	131	Shared Neighborhood Hits	75
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

DGKE_HUMAN
NC score	0.838304 (rank : 7)	θ value	1.5519e-76 (rank : 9)
Query Neighborhood Hits	238	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	P52429, Q9UKQ3	Gene names	DGKE, DAGK5
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

DGKE_MOUSE
NC score	0.836264 (rank : 8)	θ value	5.8972e-76 (rank : 10)
Query Neighborhood Hits	238	Target Neighborhood Hits	30	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1C6	Gene names	Dgke
Domain Architecture
Description	Diacylglycerol kinase epsilon (EC 2.7.1.107) (Diglyceride kinase epsilon) (DGK-epsilon) (DAG kinase epsilon).

DGKD_HUMAN
NC score	0.779627 (rank : 9)	θ value	3.71957e-54 (rank : 12)
Query Neighborhood Hits	238	Target Neighborhood Hits	231	Shared Neighborhood Hits	68
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKH_HUMAN
NC score	0.774345 (rank : 10)	θ value	3.1488e-53 (rank : 13)
Query Neighborhood Hits	238	Target Neighborhood Hits	255	Shared Neighborhood Hits	70
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKK_HUMAN
NC score	0.696841 (rank : 11)	θ value	4.86918e-46 (rank : 14)
Query Neighborhood Hits	238	Target Neighborhood Hits	378	Shared Neighborhood Hits	38
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DGKZ_MOUSE
NC score	0.693975 (rank : 12)	θ value	2.82823e-78 (rank : 8)
Query Neighborhood Hits	238	Target Neighborhood Hits	542	Shared Neighborhood Hits	33
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKZ_HUMAN
NC score	0.690012 (rank : 13)	θ value	3.34088e-79 (rank : 7)
Query Neighborhood Hits	238	Target Neighborhood Hits	551	Shared Neighborhood Hits	32
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DGKI_HUMAN
NC score	0.683806 (rank : 14)	θ value	1.10959e-82 (rank : 6)
Query Neighborhood Hits	238	Target Neighborhood Hits	609	Shared Neighborhood Hits	35
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

GUC1A_MOUSE
NC score	0.381290 (rank : 15)	θ value	8.97725e-08 (rank : 34)
Query Neighborhood Hits	238	Target Neighborhood Hits	152	Shared Neighborhood Hits	115
SwissProt Accessions	P43081	Gene names	Guca1a, Gcap, Gcap1, Guca1
Domain Architecture
Description	Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A).

GUC1A_HUMAN
NC score	0.379713 (rank : 16)	θ value	2.36244e-08 (rank : 24)
Query Neighborhood Hits	238	Target Neighborhood Hits	147	Shared Neighborhood Hits	114
SwissProt Accessions	P43080, Q9NU14	Gene names	GUCA1A, GCAP, GCAP1, GUCA1
Domain Architecture
Description	Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A).

NCALD_HUMAN
NC score	0.368571 (rank : 17)	θ value	3.08544e-08 (rank : 31)
Query Neighborhood Hits	238	Target Neighborhood Hits	153	Shared Neighborhood Hits	106
SwissProt Accessions	P61601, P29554, Q8IYC3, Q9H0W2	Gene names	NCALD
Domain Architecture
Description	Neurocalcin delta.

NCALD_MOUSE
NC score	0.368571 (rank : 18)	θ value	3.08544e-08 (rank : 32)
Query Neighborhood Hits	238	Target Neighborhood Hits	153	Shared Neighborhood Hits	106
SwissProt Accessions	Q91X97, Q3TJS9, Q8BZN9	Gene names	Ncald, D15Ertd412e
Domain Architecture
Description	Neurocalcin delta.

HPCL1_MOUSE
NC score	0.368408 (rank : 19)	θ value	1.06045e-08 (rank : 21)
Query Neighborhood Hits	238	Target Neighborhood Hits	149	Shared Neighborhood Hits	107
SwissProt Accessions	P62748, P35333	Gene names	Hpcal1
Domain Architecture	No domain graphic available
Description	Hippocalcin-like protein 1 (Visinin-like protein 3) (VILIP-3) (Neural visinin-like protein 3) (NVL-3) (NVP-3).

HPCA_HUMAN
NC score	0.366727 (rank : 20)	θ value	2.36244e-08 (rank : 25)
Query Neighborhood Hits	238	Target Neighborhood Hits	156	Shared Neighborhood Hits	108
SwissProt Accessions	P84074, P32076, P41211, P70510	Gene names	HPCA, BDR2
Domain Architecture	No domain graphic available
Description	Neuron-specific calcium-binding protein hippocalcin (Calcium-binding protein BDR-2).

HPCA_MOUSE
NC score	0.366727 (rank : 21)	θ value	2.36244e-08 (rank : 26)
Query Neighborhood Hits	238	Target Neighborhood Hits	156	Shared Neighborhood Hits	108
SwissProt Accessions	P84075, P32076, P41211, P70510	Gene names	Hpca
Domain Architecture	No domain graphic available
Description	Neuron-specific calcium-binding protein hippocalcin.

HPCL1_HUMAN
NC score	0.366385 (rank : 22)	θ value	3.08544e-08 (rank : 29)
Query Neighborhood Hits	238	Target Neighborhood Hits	150	Shared Neighborhood Hits	104
SwissProt Accessions	P37235, Q969S5	Gene names	HPCAL1, BDR1
Domain Architecture
Description	Hippocalcin-like protein 1 (Visinin-like protein 3) (VILIP-3) (Calcium-binding protein BDR-1) (HLP2).

GUC1C_HUMAN
NC score	0.362420 (rank : 23)	θ value	4.92598e-06 (rank : 44)
Query Neighborhood Hits	238	Target Neighborhood Hits	148	Shared Neighborhood Hits	111
SwissProt Accessions	O95843, O95844, Q9UNM0	Gene names	GUCA1C, GCAP3
Domain Architecture
Description	Guanylyl cyclase-activating protein 3 (GCAP 3) (Guanylate cyclase activator 1C).

KIP1_MOUSE
NC score	0.361798 (rank : 24)	θ value	2.21117e-06 (rank : 39)
Query Neighborhood Hits	238	Target Neighborhood Hits	109	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z0F4, Q3TN80	Gene names	Cib1, Cib, Kip, Prkdcip
Domain Architecture
Description	Calcium and integrin-binding protein 1 (Calmyrin) (DNA-PKcs- interacting protein) (Kinase-interacting protein) (KIP) (CIB).

GUC1B_HUMAN
NC score	0.358010 (rank : 25)	θ value	9.92553e-07 (rank : 37)
Query Neighborhood Hits	238	Target Neighborhood Hits	124	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UMX6, Q9NU15	Gene names	GUCA1B, GCAP2
Domain Architecture
Description	Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B).

GUC1B_MOUSE
NC score	0.355739 (rank : 26)	θ value	7.1131e-05 (rank : 62)
Query Neighborhood Hits	238	Target Neighborhood Hits	116	Shared Neighborhood Hits	90
SwissProt Accessions	Q8VBV8	Gene names	Guca1b
Domain Architecture	No domain graphic available
Description	Guanylyl cyclase-activating protein 2 (GCAP 2) (Guanylate cyclase activator 1B).

KIP1_HUMAN
NC score	0.350796 (rank : 27)	θ value	2.88788e-06 (rank : 40)
Query Neighborhood Hits	238	Target Neighborhood Hits	105	Shared Neighborhood Hits	87
SwissProt Accessions	Q99828, O00693, O00735, Q6IB49, Q96J54, Q99971	Gene names	CIB1, CIB, KIP, PRKDCIP
Domain Architecture
Description	Calcium and integrin-binding protein 1 (Calmyrin) (DNA-PKcs- interacting protein) (Kinase-interacting protein) (KIP) (CIB) (SNK- interacting protein 2-28) (SIP2-28).

CANB2_MOUSE
NC score	0.340583 (rank : 28)	θ value	4.1701e-05 (rank : 56)
Query Neighborhood Hits	238	Target Neighborhood Hits	173	Shared Neighborhood Hits	111
SwissProt Accessions	Q63811	Gene names	Ppp3r2
Domain Architecture
Description	Calcineurin subunit B isoform 2 (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform).

EFCB1_HUMAN
NC score	0.338671 (rank : 29)	θ value	9.29e-05 (rank : 63)
Query Neighborhood Hits	238	Target Neighborhood Hits	121	Shared Neighborhood Hits	97
SwissProt Accessions	Q9HAE3	Gene names	EFCAB1
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 1.

HPCL4_MOUSE
NC score	0.336622 (rank : 30)	θ value	1.87187e-05 (rank : 51)
Query Neighborhood Hits	238	Target Neighborhood Hits	123	Shared Neighborhood Hits	93
SwissProt Accessions	Q8BGZ1	Gene names	Hpcal4
Domain Architecture	No domain graphic available
Description	Hippocalcin-like protein 4 (Neural visinin-like protein 2) (NVP-2).

HPCL4_HUMAN
NC score	0.336450 (rank : 31)	θ value	1.87187e-05 (rank : 50)
Query Neighborhood Hits	238	Target Neighborhood Hits	123	Shared Neighborhood Hits	93
SwissProt Accessions	Q9UM19, Q5TG97, Q8N611	Gene names	HPCAL4
Domain Architecture	No domain graphic available
Description	Hippocalcin-like protein 4 (HLP4).

CANB1_MOUSE
NC score	0.333861 (rank : 32)	θ value	5.44631e-05 (rank : 58)
Query Neighborhood Hits	238	Target Neighborhood Hits	183	Shared Neighborhood Hits	109
SwissProt Accessions	Q63810	Gene names	Ppp3r1, Cnb
Domain Architecture
Description	Calcineurin subunit B isoform 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1).

CANB1_HUMAN
NC score	0.333845 (rank : 33)	θ value	5.44631e-05 (rank : 57)
Query Neighborhood Hits	238	Target Neighborhood Hits	183	Shared Neighborhood Hits	109
SwissProt Accessions	P63098, P06705, P15117, Q08044	Gene names	PPP3R1, CNA2, CNB
Domain Architecture	No domain graphic available
Description	Calcineurin subunit B isoform 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1).

KCIP1_MOUSE
NC score	0.333202 (rank : 34)	θ value	1.43324e-05 (rank : 49)
Query Neighborhood Hits	238	Target Neighborhood Hits	113	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JJ57, Q5SSA3, Q6DTJ1, Q8BGJ4, Q8C4K4, Q8CGL1, Q8K1U1, Q8K3M2	Gene names	Kcnip1, Kchip1
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 1 (KChIP1) (A-type potassium channel modulatory protein 1) (Potassium channel-interacting protein 1).

KCIP1_HUMAN
NC score	0.332364 (rank : 35)	θ value	2.44474e-05 (rank : 53)
Query Neighborhood Hits	238	Target Neighborhood Hits	113	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NZI2, Q5U822	Gene names	KCNIP1, KCHIP1, VABP
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 1 (KChIP1) (A-type potassium channel modulatory protein 1) (Potassium channel-interacting protein 1) (Vesicle APC-binding protein).

NCS1_HUMAN
NC score	0.331117 (rank : 36)	θ value	0.000602161 (rank : 82)
Query Neighborhood Hits	238	Target Neighborhood Hits	132	Shared Neighborhood Hits	101
SwissProt Accessions	P62166, P36610, Q9UK26	Gene names	FREQ, FLUP, NCS1
Domain Architecture
Description	Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein).

NCS1_MOUSE
NC score	0.331117 (rank : 37)	θ value	0.000602161 (rank : 83)
Query Neighborhood Hits	238	Target Neighborhood Hits	132	Shared Neighborhood Hits	101
SwissProt Accessions	Q8BNY6	Gene names	Freq, Ncs1
Domain Architecture
Description	Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog).

CANB2_HUMAN
NC score	0.331037 (rank : 38)	θ value	0.000786445 (rank : 87)
Query Neighborhood Hits	238	Target Neighborhood Hits	163	Shared Neighborhood Hits	106
SwissProt Accessions	Q96LZ3, Q7Z4V8, Q8WYJ4	Gene names	PPP3R2, CBLP
Domain Architecture	No domain graphic available
Description	Calcineurin subunit B isoform 2 (Protein phosphatase 2B regulatory subunit 2) (Protein phosphatase 3 regulatory subunit B beta isoform) (Calcineurin B-like protein) (CBLP) (CNBII).

KCIP2_HUMAN
NC score	0.330224 (rank : 39)	θ value	0.00020696 (rank : 72)
Query Neighborhood Hits	238	Target Neighborhood Hits	125	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NS61, Q7Z6F1, Q96K86, Q96T41, Q96T42, Q96T43, Q96T44, Q9H0N4, Q9HD10, Q9HD11, Q9NS60, Q9NY10, Q9NZI1	Gene names	KCNIP2, KCHIP2
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Potassium channel-interacting protein 2) (Cardiac voltage-gated potassium channel modulatory subunit).

KCIP4_MOUSE
NC score	0.329557 (rank : 40)	θ value	0.000602161 (rank : 81)
Query Neighborhood Hits	238	Target Neighborhood Hits	136	Shared Neighborhood Hits	101
SwissProt Accessions	Q6PHZ8, Q6DTJ3, Q8CAD0, Q8R4I2, Q9EQ01	Gene names	Kcnip4, Calp, Kchip4
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) (Calsenilin-like protein).

KCIP4_HUMAN
NC score	0.329436 (rank : 41)	θ value	0.000602161 (rank : 80)
Query Neighborhood Hits	238	Target Neighborhood Hits	136	Shared Neighborhood Hits	101
SwissProt Accessions	Q6PIL6, Q4W5G8, Q8NEU0, Q9BWT2, Q9H294, Q9H2A4	Gene names	KCNIP4, CALP, KCHIP4
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Potassium channel-interacting protein 4) (Calsenilin-like protein).

VISL1_HUMAN
NC score	0.328504 (rank : 42)	θ value	0.000158464 (rank : 70)
Query Neighborhood Hits	238	Target Neighborhood Hits	124	Shared Neighborhood Hits	93
SwissProt Accessions	P62760, P28677, P29103, P42323, Q9UM20	Gene names	VSNL1, VISL1
Domain Architecture	No domain graphic available
Description	Visinin-like protein 1 (VILIP) (Hippocalcin-like protein 3) (HLP3).

VISL1_MOUSE
NC score	0.328504 (rank : 43)	θ value	0.000158464 (rank : 71)
Query Neighborhood Hits	238	Target Neighborhood Hits	124	Shared Neighborhood Hits	93
SwissProt Accessions	P62761, P28677, P29103, P42323, Q9UM20	Gene names	Vsnl1, Visl1
Domain Architecture	No domain graphic available
Description	Visinin-like protein 1 (VILIP) (Neural visinin-like protein 1) (NVL-1) (NVP-1).

KCIP2_MOUSE
NC score	0.328053 (rank : 44)	θ value	0.000270298 (rank : 75)
Query Neighborhood Hits	238	Target Neighborhood Hits	124	Shared Neighborhood Hits	95
SwissProt Accessions	Q9JJ69, Q6DTJ2, Q8K1T8, Q8K1T9, Q8K1U0, Q8VHN4, Q8VHN5, Q8VHN6, Q9JJ68	Gene names	Kcnip2, Kchip2
Domain Architecture	No domain graphic available
Description	Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Potassium channel-interacting protein 2).

RECO_MOUSE
NC score	0.325595 (rank : 45)	θ value	0.000786445 (rank : 88)
Query Neighborhood Hits	238	Target Neighborhood Hits	108	Shared Neighborhood Hits	79
SwissProt Accessions	P34057	Gene names	Rcvrn, Rcv1
Domain Architecture
Description	Recoverin (Cancer-associated retinopathy protein) (Protein CAR) (23 kDa photoreceptor cell-specific protein).

EFCB1_MOUSE
NC score	0.320383 (rank : 46)	θ value	0.000270298 (rank : 73)
Query Neighborhood Hits	238	Target Neighborhood Hits	126	Shared Neighborhood Hits	98
SwissProt Accessions	Q9D3N2, Q8BSW3, Q8C982, Q8CAI0, Q9D527, Q9D5E7	Gene names	Efcab1
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 1.

CSEN_HUMAN
NC score	0.320153 (rank : 47)	θ value	1.43324e-05 (rank : 48)
Query Neighborhood Hits	238	Target Neighborhood Hits	128	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Y2W7, Q53TJ5, Q96T40, Q9UJ84, Q9UJ85	Gene names	KCNIP3, CSEN, DREAM, KCHIP3
Domain Architecture
Description	Calsenilin (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3) (A-type potassium channel modulatory protein 3).

CSEN_MOUSE
NC score	0.314710 (rank : 48)	θ value	0.000158464 (rank : 68)
Query Neighborhood Hits	238	Target Neighborhood Hits	117	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QXT8, Q924L0, Q99PH9, Q99PI0, Q99PI2, Q99PI3, Q9JHZ5	Gene names	Kcnip3, Csen, Dream, Kchip3
Domain Architecture
Description	Calsenilin (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (A-type potassium channel modulatory protein 3) (KChIP3).

RECO_HUMAN
NC score	0.314402 (rank : 49)	θ value	0.00665767 (rank : 96)
Query Neighborhood Hits	238	Target Neighborhood Hits	101	Shared Neighborhood Hits	76
SwissProt Accessions	P35243	Gene names	RCVRN, RCV1
Domain Architecture
Description	Recoverin (Cancer-associated retinopathy protein) (Protein CAR).

GRP3_HUMAN
NC score	0.295170 (rank : 50)	θ value	0.000270298 (rank : 74)
Query Neighborhood Hits	238	Target Neighborhood Hits	131	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

CHP2_MOUSE
NC score	0.290514 (rank : 51)	θ value	0.0252991 (rank : 106)
Query Neighborhood Hits	238	Target Neighborhood Hits	122	Shared Neighborhood Hits	94
SwissProt Accessions	Q9D869	Gene names	Chp2, Hca520
Domain Architecture
Description	Calcineurin B homologous protein 2 (Hepatocellular carcinoma- associated antigen 520 homolog).

CHP1_MOUSE
NC score	0.281466 (rank : 52)	θ value	0.0431538 (rank : 112)
Query Neighborhood Hits	238	Target Neighborhood Hits	117	Shared Neighborhood Hits	94
SwissProt Accessions	P61022, Q62877, Q6ZWQ8	Gene names	Chp, Sid470
Domain Architecture
Description	Calcium-binding protein p22 (Calcium-binding protein CHP) (Calcineurin homologous protein) (Sid 470).

CHP2_HUMAN
NC score	0.278199 (rank : 53)	θ value	0.0736092 (rank : 122)
Query Neighborhood Hits	238	Target Neighborhood Hits	122	Shared Neighborhood Hits	91
SwissProt Accessions	O43745	Gene names	CHP2, HCA520
Domain Architecture
Description	Calcineurin B homologous protein 2 (Hepatocellular carcinoma- associated antigen 520).

CHP1_HUMAN
NC score	0.276439 (rank : 54)	θ value	0.0563607 (rank : 117)
Query Neighborhood Hits	238	Target Neighborhood Hits	114	Shared Neighborhood Hits	91
SwissProt Accessions	Q99653	Gene names	CHP
Domain Architecture
Description	Calcium-binding protein p22 (Calcium-binding protein CHP) (Calcineurin homologous protein) (Calcineurin B homolog).

RASF1_MOUSE
NC score	0.261933 (rank : 55)	θ value	0.00390308 (rank : 92)
Query Neighborhood Hits	238	Target Neighborhood Hits	74	Shared Neighborhood Hits	58
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

STAC_MOUSE
NC score	0.248222 (rank : 56)	θ value	0.000121331 (rank : 67)
Query Neighborhood Hits	238	Target Neighborhood Hits	268	Shared Neighborhood Hits	64
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_HUMAN
NC score	0.239927 (rank : 57)	θ value	0.000158464 (rank : 69)
Query Neighborhood Hits	238	Target Neighborhood Hits	276	Shared Neighborhood Hits	64
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

KIP2_HUMAN
NC score	0.235408 (rank : 58)	θ value	0.62314 (rank : 154)
Query Neighborhood Hits	238	Target Neighborhood Hits	107	Shared Neighborhood Hits	85
SwissProt Accessions	O75838	Gene names	CIB2, KIP2
Domain Architecture	No domain graphic available
Description	Calcium and integrin-binding protein 2 (Kinase-interacting protein 2) (KIP 2).

STAC3_MOUSE
NC score	0.232088 (rank : 59)	θ value	0.000270298 (rank : 77)
Query Neighborhood Hits	238	Target Neighborhood Hits	232	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.231893 (rank : 60)	θ value	0.000270298 (rank : 76)
Query Neighborhood Hits	238	Target Neighborhood Hits	228	Shared Neighborhood Hits	57
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

KIP2_MOUSE
NC score	0.229931 (rank : 61)	θ value	1.38821 (rank : 169)
Query Neighborhood Hits	238	Target Neighborhood Hits	110	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z309	Gene names	Cib2, Kip2
Domain Architecture	No domain graphic available
Description	Calcium and integrin-binding protein 2 (Kinase-interacting protein 2) (KIP 2).

UN13B_HUMAN
NC score	0.220189 (rank : 62)	θ value	0.0193708 (rank : 105)
Query Neighborhood Hits	238	Target Neighborhood Hits	217	Shared Neighborhood Hits	68
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13A_HUMAN
NC score	0.219232 (rank : 63)	θ value	0.0431538 (rank : 114)
Query Neighborhood Hits	238	Target Neighborhood Hits	285	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

CHIO_MOUSE
NC score	0.217563 (rank : 64)	θ value	0.00035302 (rank : 79)
Query Neighborhood Hits	238	Target Neighborhood Hits	130	Shared Neighborhood Hits	66
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

KIP3_HUMAN
NC score	0.214512 (rank : 65)	θ value	0.0148317 (rank : 102)
Query Neighborhood Hits	238	Target Neighborhood Hits	83	Shared Neighborhood Hits	75
SwissProt Accessions	Q96Q77	Gene names	CIB3, KIP3
Domain Architecture
Description	Calcium and integrin-binding protein 3 (Kinase-interacting protein 3) (KIP 3).

CABP7_HUMAN
NC score	0.212105 (rank : 66)	θ value	0.000786445 (rank : 84)
Query Neighborhood Hits	238	Target Neighborhood Hits	205	Shared Neighborhood Hits	104
SwissProt Accessions	Q86V35	Gene names	CABP7
Domain Architecture
Description	Calcium-binding protein 7 (CaBP7).

CABP7_MOUSE
NC score	0.212105 (rank : 67)	θ value	0.000786445 (rank : 85)
Query Neighborhood Hits	238	Target Neighborhood Hits	205	Shared Neighborhood Hits	104
SwissProt Accessions	Q91ZM8	Gene names	Cabp7
Domain Architecture
Description	Calcium-binding protein 7 (CaBP7).

TNNC1_HUMAN
NC score	0.209814 (rank : 68)	θ value	0.0330416 (rank : 110)
Query Neighborhood Hits	238	Target Neighborhood Hits	219	Shared Neighborhood Hits	111
SwissProt Accessions	P63316, O14800, P02590, P04463	Gene names	TNNC1, TNNC
Domain Architecture	No domain graphic available
Description	Troponin C, slow skeletal and cardiac muscles (TN-C).

TNNC1_MOUSE
NC score	0.209718 (rank : 69)	θ value	0.0252991 (rank : 107)
Query Neighborhood Hits	238	Target Neighborhood Hits	221	Shared Neighborhood Hits	111
SwissProt Accessions	P19123	Gene names	Tnnc1, Tncc
Domain Architecture
Description	Troponin C, slow skeletal and cardiac muscles (TN-C).

UN13B_MOUSE
NC score	0.209229 (rank : 70)	θ value	0.0736092 (rank : 124)
Query Neighborhood Hits	238	Target Neighborhood Hits	210	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

CHIO_HUMAN
NC score	0.209020 (rank : 71)	θ value	0.00035302 (rank : 78)
Query Neighborhood Hits	238	Target Neighborhood Hits	220	Shared Neighborhood Hits	66
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CALM_HUMAN
NC score	0.208113 (rank : 72)	θ value	0.000121331 (rank : 65)
Query Neighborhood Hits	238	Target Neighborhood Hits	232	Shared Neighborhood Hits	112
SwissProt Accessions	P62158, P02593, P70667, P99014, Q13942, Q53S29, Q61379, Q61380, Q96HK3	Gene names	CALM1, CALM, CAM, CAM1
Domain Architecture
Description	Calmodulin (CaM).

CALM_MOUSE
NC score	0.208113 (rank : 73)	θ value	0.000121331 (rank : 66)
Query Neighborhood Hits	238	Target Neighborhood Hits	232	Shared Neighborhood Hits	112
SwissProt Accessions	P62204, P02593, P70667, P99014, Q61379, Q61380	Gene names	Calm1, Calm, Cam, Cam1
Domain Architecture
Description	Calmodulin (CaM).

CALL3_HUMAN
NC score	0.205161 (rank : 74)	θ value	0.000786445 (rank : 86)
Query Neighborhood Hits	238	Target Neighborhood Hits	225	Shared Neighborhood Hits	112
SwissProt Accessions	P27482	Gene names	CALML3
Domain Architecture
Description	Calmodulin-like protein 3 (Calmodulin-related protein NB-1) (CaM-like protein) (CLP).

TNNC2_MOUSE
NC score	0.204661 (rank : 75)	θ value	0.0563607 (rank : 119)
Query Neighborhood Hits	238	Target Neighborhood Hits	233	Shared Neighborhood Hits	110
SwissProt Accessions	P20801	Gene names	Tnnc2, Tncs
Domain Architecture
Description	Troponin C, skeletal muscle (STNC).

CHIN_HUMAN
NC score	0.204645 (rank : 76)	θ value	0.00298849 (rank : 90)
Query Neighborhood Hits	238	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CALM4_MOUSE
NC score	0.204057 (rank : 77)	θ value	0.163984 (rank : 132)
Query Neighborhood Hits	238	Target Neighborhood Hits	229	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JM83, Q9CR31, Q9D1E9	Gene names	Calm4, Dd112
Domain Architecture
Description	Calmodulin-4 (Calcium-binding protein Dd112).

TNNC2_HUMAN
NC score	0.201900 (rank : 78)	θ value	0.21417 (rank : 137)
Query Neighborhood Hits	238	Target Neighborhood Hits	234	Shared Neighborhood Hits	111
SwissProt Accessions	P02585	Gene names	TNNC2
Domain Architecture
Description	Troponin C, skeletal muscle.

CHIN_MOUSE
NC score	0.200673 (rank : 79)	θ value	0.00298849 (rank : 91)
Query Neighborhood Hits	238	Target Neighborhood Hits	229	Shared Neighborhood Hits	64
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CALL5_HUMAN
NC score	0.196983 (rank : 80)	θ value	0.62314 (rank : 152)
Query Neighborhood Hits	238	Target Neighborhood Hits	231	Shared Neighborhood Hits	111
SwissProt Accessions	Q9NZT1, Q8IXU8	Gene names	CALML5, CLSP
Domain Architecture
Description	Calmodulin-like protein 5 (Calmodulin-like skin protein).

DUOX1_HUMAN
NC score	0.195131 (rank : 81)	θ value	0.00665767 (rank : 95)
Query Neighborhood Hits	238	Target Neighborhood Hits	172	Shared Neighborhood Hits	91
SwissProt Accessions	Q9NRD9, Q6ZMB3, Q6ZR09, Q9NZC1	Gene names	DUOX1, DUOX, LNOX1, THOX1
Domain Architecture	No domain graphic available
Description	Dual oxidase 1 precursor (EC 1.6.3.1) (EC 1.11.1.-) (NADPH thyroid oxidase 1) (Thyroid oxidase 1) (Large NOX 1) (Long NOX 1).

DUOX2_HUMAN
NC score	0.193247 (rank : 82)	θ value	0.0113563 (rank : 97)
Query Neighborhood Hits	238	Target Neighborhood Hits	139	Shared Neighborhood Hits	85
SwissProt Accessions	Q9NRD8, Q9NR02, Q9UHF9	Gene names	DUOX2, LNOX2, THOX2
Domain Architecture	No domain graphic available
Description	Dual oxidase 2 precursor (EC 1.6.3.1) (EC 1.11.1.-) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (NADH/NADPH thyroid oxidase p138-tox) (p138 thyroid oxidase) (Large NOX 2) (Long NOX 2).

PDZD8_HUMAN
NC score	0.192945 (rank : 83)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	238	Target Neighborhood Hits	185	Shared Neighborhood Hits	59
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

CALB2_MOUSE
NC score	0.191659 (rank : 84)	θ value	0.0736092 (rank : 121)
Query Neighborhood Hits	238	Target Neighborhood Hits	141	Shared Neighborhood Hits	93
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

CALB2_HUMAN
NC score	0.189023 (rank : 85)	θ value	0.0736092 (rank : 120)
Query Neighborhood Hits	238	Target Neighborhood Hits	149	Shared Neighborhood Hits	94
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

RASF1_HUMAN
NC score	0.187021 (rank : 86)	θ value	1.06291 (rank : 162)
Query Neighborhood Hits	238	Target Neighborhood Hits	62	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

CALB1_HUMAN
NC score	0.176187 (rank : 87)	θ value	0.0148317 (rank : 100)
Query Neighborhood Hits	238	Target Neighborhood Hits	130	Shared Neighborhood Hits	87
SwissProt Accessions	P05937	Gene names	CALB1, CAB27
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K).

CALB1_MOUSE
NC score	0.175404 (rank : 88)	θ value	0.0148317 (rank : 101)
Query Neighborhood Hits	238	Target Neighborhood Hits	129	Shared Neighborhood Hits	86
SwissProt Accessions	P12658, Q545N6	Gene names	Calb1
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K) (Spot 35 protein) (PCD-29).

CABP4_HUMAN
NC score	0.174421 (rank : 89)	θ value	0.21417 (rank : 136)
Query Neighborhood Hits	238	Target Neighborhood Hits	250	Shared Neighborhood Hits	106
SwissProt Accessions	P57796, Q8N4Z2, Q8WWY5	Gene names	CABP4
Domain Architecture
Description	Calcium-binding protein 4 (CaBP4).

EFHD1_HUMAN
NC score	0.174166 (rank : 90)	θ value	0.0113563 (rank : 98)
Query Neighborhood Hits	238	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BUP0, Q9BTF8, Q9H8I2, Q9HBQ0	Gene names	EFHD1, SWS2
Domain Architecture
Description	EF-hand domain-containing protein 1 (Swiprosin-2).

CABP4_MOUSE
NC score	0.170454 (rank : 91)	θ value	1.06291 (rank : 161)
Query Neighborhood Hits	238	Target Neighborhood Hits	212	Shared Neighborhood Hits	104
SwissProt Accessions	Q8VHC5	Gene names	Cabp4
Domain Architecture	No domain graphic available
Description	Calcium-binding protein 4 (CaBP4).

NOX5_HUMAN
NC score	0.170398 (rank : 92)	θ value	0.0431538 (rank : 113)
Query Neighborhood Hits	238	Target Neighborhood Hits	89	Shared Neighborhood Hits	65
SwissProt Accessions	Q96PH1, Q8TEQ1, Q8TER4, Q96PH2, Q96PJ8, Q96PJ9, Q9H6E0, Q9HAM8	Gene names	NOX5
Domain Architecture	No domain graphic available
Description	NADPH oxidase 5 (EC 1.6.3.-).

CETN2_HUMAN
NC score	0.170066 (rank : 93)	θ value	3.0926 (rank : 191)
Query Neighborhood Hits	238	Target Neighborhood Hits	213	Shared Neighborhood Hits	104
SwissProt Accessions	P41208, Q53XW1	Gene names	CETN2, CALT, CEN2
Domain Architecture
Description	Centrin-2 (Caltractin isoform 1).

CETN2_MOUSE
NC score	0.169459 (rank : 94)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	238	Target Neighborhood Hits	211	Shared Neighborhood Hits	104
SwissProt Accessions	Q9R1K9, Q3UBB4, Q9CWM0	Gene names	Cetn2, Calt
Domain Architecture
Description	Centrin-2 (Caltractin isoform 1).

CETN1_HUMAN
NC score	0.169027 (rank : 95)	θ value	1.81305 (rank : 175)
Query Neighborhood Hits	238	Target Neighborhood Hits	232	Shared Neighborhood Hits	107
SwissProt Accessions	Q12798	Gene names	CETN1, CEN1, CETN
Domain Architecture
Description	Centrin-1 (Caltractin isoform 2).

CABP3_HUMAN
NC score	0.166579 (rank : 96)	θ value	1.81305 (rank : 174)
Query Neighborhood Hits	238	Target Neighborhood Hits	162	Shared Neighborhood Hits	89
SwissProt Accessions	Q9NZU6, Q9NYY0, Q9NZT9	Gene names	CABP3
Domain Architecture
Description	Calcium-binding protein 3 (CaBP3).

CETN1_MOUSE
NC score	0.165178 (rank : 97)	θ value	1.81305 (rank : 176)
Query Neighborhood Hits	238	Target Neighborhood Hits	231	Shared Neighborhood Hits	106
SwissProt Accessions	P41209, Q3V119, Q9D9G9, Q9DAL6	Gene names	Cetn1, Calt
Domain Architecture
Description	Centrin-1 (Caltractin).

CALN1_HUMAN
NC score	0.164524 (rank : 98)	θ value	0.0563607 (rank : 115)
Query Neighborhood Hits	238	Target Neighborhood Hits	161	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BXU9	Gene names	CALN1, CABP8
Domain Architecture
Description	Calneuron-1 (Calcium-binding protein CaBP8).

CALN1_MOUSE
NC score	0.164259 (rank : 99)	θ value	0.0563607 (rank : 116)
Query Neighborhood Hits	238	Target Neighborhood Hits	161	Shared Neighborhood Hits	88
SwissProt Accessions	Q9JJG7	Gene names	Caln1
Domain Architecture
Description	Calneuron-1.

AYTL1_HUMAN
NC score	0.164199 (rank : 100)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	238	Target Neighborhood Hits	140	Shared Neighborhood Hits	89
SwissProt Accessions	Q7L5N7, Q6MZJ6, Q9NX23	Gene names	AYTL1
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1 (EC 2.3.1.-).

CETN3_MOUSE
NC score	0.162492 (rank : 101)	θ value	1.38821 (rank : 166)
Query Neighborhood Hits	238	Target Neighborhood Hits	208	Shared Neighborhood Hits	104
SwissProt Accessions	O35648	Gene names	Cetn3, Cen3
Domain Architecture
Description	Centrin-3.

CETN3_HUMAN
NC score	0.162111 (rank : 102)	θ value	1.38821 (rank : 165)
Query Neighborhood Hits	238	Target Neighborhood Hits	211	Shared Neighborhood Hits	104
SwissProt Accessions	O15182, Q9BS23	Gene names	CETN3, CEN3
Domain Architecture
Description	Centrin-3.

EFHD1_MOUSE
NC score	0.161697 (rank : 103)	θ value	0.0563607 (rank : 118)
Query Neighborhood Hits	238	Target Neighborhood Hits	108	Shared Neighborhood Hits	75
SwissProt Accessions	Q9D4J1, Q543U4	Gene names	Efhd1, Sws2
Domain Architecture
Description	EF-hand domain-containing protein 1 (Swiprosin-2).

CABP2_MOUSE
NC score	0.159284 (rank : 104)	θ value	3.0926 (rank : 190)
Query Neighborhood Hits	238	Target Neighborhood Hits	204	Shared Neighborhood Hits	101
SwissProt Accessions	Q9JLK4, Q9JLK5	Gene names	Cabp2
Domain Architecture
Description	Calcium-binding protein 2 (CaBP2).

KPCL_HUMAN
NC score	0.157465 (rank : 105)	θ value	6.87365e-08 (rank : 33)
Query Neighborhood Hits	238	Target Neighborhood Hits	887	Shared Neighborhood Hits	70
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCD_MOUSE
NC score	0.157004 (rank : 106)	θ value	8.11959e-09 (rank : 20)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	73
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_HUMAN
NC score	0.156788 (rank : 107)	θ value	3.64472e-09 (rank : 19)
Query Neighborhood Hits	238	Target Neighborhood Hits	900	Shared Neighborhood Hits	74
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCG_HUMAN
NC score	0.155924 (rank : 108)	θ value	2.79066e-09 (rank : 17)
Query Neighborhood Hits	238	Target Neighborhood Hits	1126	Shared Neighborhood Hits	85
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_MOUSE
NC score	0.155594 (rank : 109)	θ value	2.79066e-09 (rank : 18)
Query Neighborhood Hits	238	Target Neighborhood Hits	1123	Shared Neighborhood Hits	85
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

CABP2_HUMAN
NC score	0.155047 (rank : 110)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	238	Target Neighborhood Hits	205	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NPB3	Gene names	CABP2
Domain Architecture
Description	Calcium-binding protein 2 (CaBP2).

KPCE_MOUSE
NC score	0.154746 (rank : 111)	θ value	3.08544e-08 (rank : 30)
Query Neighborhood Hits	238	Target Neighborhood Hits	906	Shared Neighborhood Hits	69
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

AYT1A_MOUSE
NC score	0.154633 (rank : 112)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	238	Target Neighborhood Hits	126	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BYI6	Gene names	Aytl1a, Aytl1
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1-A (EC 2.3.1.-).

KPCE_HUMAN
NC score	0.154498 (rank : 113)	θ value	2.36244e-08 (rank : 27)
Query Neighborhood Hits	238	Target Neighborhood Hits	906	Shared Neighborhood Hits	69
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KPCL_MOUSE
NC score	0.154198 (rank : 114)	θ value	2.36244e-08 (rank : 28)
Query Neighborhood Hits	238	Target Neighborhood Hits	891	Shared Neighborhood Hits	70
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

TESC_HUMAN
NC score	0.153940 (rank : 115)	θ value	0.62314 (rank : 156)
Query Neighborhood Hits	238	Target Neighborhood Hits	64	Shared Neighborhood Hits	56
SwissProt Accessions	Q96BS2	Gene names	TESC
Domain Architecture	No domain graphic available
Description	Tescalcin (TSC).

AYT1B_MOUSE
NC score	0.153044 (rank : 116)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	238	Target Neighborhood Hits	113	Shared Neighborhood Hits	73
SwissProt Accessions	Q9D5U0	Gene names	Aytl1b
Domain Architecture	No domain graphic available
Description	Acyltransferase-like 1-B (EC 2.3.1.-).

CABP1_HUMAN
NC score	0.152460 (rank : 117)	θ value	0.47712 (rank : 144)
Query Neighborhood Hits	238	Target Neighborhood Hits	197	Shared Neighborhood Hits	96
SwissProt Accessions	Q9NZU7, O95663, Q9NZU8	Gene names	CABP1
Domain Architecture
Description	Calcium-binding protein 1 (CaBP1) (Calbrain).

CABP1_MOUSE
NC score	0.152410 (rank : 118)	θ value	0.47712 (rank : 145)
Query Neighborhood Hits	238	Target Neighborhood Hits	197	Shared Neighborhood Hits	96
SwissProt Accessions	Q9JLK7, Q9JLK6	Gene names	Cabp1
Domain Architecture
Description	Calcium-binding protein 1 (CaBP1).

UBP32_HUMAN
NC score	0.151918 (rank : 119)	θ value	0.00134147 (rank : 89)
Query Neighborhood Hits	238	Target Neighborhood Hits	170	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NFA0, Q9BX85, Q9Y591	Gene names	USP32, USP10
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.1.2.15) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32) (Deubiquitinating enzyme 32) (NY-REN-60 antigen).

KPCB_MOUSE
NC score	0.151604 (rank : 120)	θ value	1.63604e-09 (rank : 15)
Query Neighborhood Hits	238	Target Neighborhood Hits	1117	Shared Neighborhood Hits	80
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_HUMAN
NC score	0.151562 (rank : 121)	θ value	2.13673e-09 (rank : 16)
Query Neighborhood Hits	238	Target Neighborhood Hits	1121	Shared Neighborhood Hits	80
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCT_MOUSE
NC score	0.151407 (rank : 122)	θ value	8.97725e-08 (rank : 36)
Query Neighborhood Hits	238	Target Neighborhood Hits	895	Shared Neighborhood Hits	69
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

CABP5_MOUSE
NC score	0.151325 (rank : 123)	θ value	4.03905 (rank : 197)
Query Neighborhood Hits	238	Target Neighborhood Hits	207	Shared Neighborhood Hits	102
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KPCT_HUMAN
NC score	0.150990 (rank : 124)	θ value	8.97725e-08 (rank : 35)
Query Neighborhood Hits	238	Target Neighborhood Hits	897	Shared Neighborhood Hits	69
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

CABP5_HUMAN
NC score	0.150717 (rank : 125)	θ value	4.03905 (rank : 196)
Query Neighborhood Hits	238	Target Neighborhood Hits	197	Shared Neighborhood Hits	100
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

TESC_MOUSE
NC score	0.148733 (rank : 126)	θ value	0.47712 (rank : 148)
Query Neighborhood Hits	238	Target Neighborhood Hits	63	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JKL5	Gene names	Tesc
Domain Architecture	No domain graphic available
Description	Tescalcin (TSC).

CAYP1_HUMAN
NC score	0.148679 (rank : 127)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	238	Target Neighborhood Hits	94	Shared Neighborhood Hits	67
SwissProt Accessions	Q13938, Q3MJA7, Q8WUZ3	Gene names	CAPS
Domain Architecture
Description	Calcyphosin (Calcyphosine).

KPCA_HUMAN
NC score	0.146260 (rank : 128)	θ value	1.06045e-08 (rank : 22)
Query Neighborhood Hits	238	Target Neighborhood Hits	1070	Shared Neighborhood Hits	73
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
NC score	0.145883 (rank : 129)	θ value	1.38499e-08 (rank : 23)
Query Neighborhood Hits	238	Target Neighborhood Hits	1067	Shared Neighborhood Hits	73
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

SEGN_HUMAN
NC score	0.139301 (rank : 130)	θ value	0.125558 (rank : 131)
Query Neighborhood Hits	238	Target Neighborhood Hits	96	Shared Neighborhood Hits	72
SwissProt Accessions	O76038, Q5VV44, Q96QV7, Q9UJF6	Gene names	SCGN, SECRET
Domain Architecture
Description	Secretagogin.

KPCZ_MOUSE
NC score	0.136671 (rank : 131)	θ value	6.43352e-06 (rank : 45)
Query Neighborhood Hits	238	Target Neighborhood Hits	882	Shared Neighborhood Hits	69
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_HUMAN
NC score	0.135670 (rank : 132)	θ value	3.77169e-06 (rank : 43)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	70
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

CALL6_HUMAN
NC score	0.133800 (rank : 133)	θ value	0.0431538 (rank : 111)
Query Neighborhood Hits	238	Target Neighborhood Hits	157	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TD86, Q6Q2C4	Gene names	CALML6, CAGLP, CALGP
Domain Architecture	No domain graphic available
Description	Calmodulin-like protein 6 (Calglandulin-like protein).

SEGN_MOUSE
NC score	0.130700 (rank : 134)	θ value	0.62314 (rank : 155)
Query Neighborhood Hits	238	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	Q91WD9	Gene names	Scgn
Domain Architecture
Description	Secretagogin.

ONCO_MOUSE
NC score	0.129552 (rank : 135)	θ value	1.38821 (rank : 171)
Query Neighborhood Hits	238	Target Neighborhood Hits	98	Shared Neighborhood Hits	70
SwissProt Accessions	P51879, Q62004	Gene names	Ocm
Domain Architecture
Description	Oncomodulin (OM) (Parvalbumin beta).

KPCI_MOUSE
NC score	0.128654 (rank : 136)	θ value	5.44631e-05 (rank : 60)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	68
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCI_HUMAN
NC score	0.128527 (rank : 137)	θ value	5.44631e-05 (rank : 59)
Query Neighborhood Hits	238	Target Neighborhood Hits	885	Shared Neighborhood Hits	66
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

MCFD2_HUMAN
NC score	0.127756 (rank : 138)	θ value	3.0926 (rank : 192)
Query Neighborhood Hits	238	Target Neighborhood Hits	62	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NI22, Q8N3M5	Gene names	MCFD2, SDNSF
Domain Architecture
Description	Multiple coagulation factor deficiency protein 2 precursor (Neural stem cell-derived neuronal survival protein).

ONCO_HUMAN
NC score	0.127696 (rank : 139)	θ value	1.81305 (rank : 181)
Query Neighborhood Hits	238	Target Neighborhood Hits	88	Shared Neighborhood Hits	61
SwissProt Accessions	P32930	Gene names	OCM, OCMN
Domain Architecture
Description	Oncomodulin (OM) (Parvalbumin beta).

MRCKG_MOUSE
NC score	0.125154 (rank : 140)	θ value	9.92553e-07 (rank : 38)
Query Neighborhood Hits	238	Target Neighborhood Hits	1466	Shared Neighborhood Hits	59
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_HUMAN
NC score	0.122624 (rank : 141)	θ value	2.88788e-06 (rank : 41)
Query Neighborhood Hits	238	Target Neighborhood Hits	1519	Shared Neighborhood Hits	62
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MCFD2_MOUSE
NC score	0.121259 (rank : 142)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	238	Target Neighborhood Hits	61	Shared Neighborhood Hits	55
SwissProt Accessions	Q8K5B2, Q3U9G5	Gene names	Mcfd2, Sdnsf
Domain Architecture
Description	Multiple coagulation factor deficiency protein 2 homolog precursor (Neural stem cell-derived neuronal survival protein).

PRVA_MOUSE
NC score	0.120556 (rank : 143)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	238	Target Neighborhood Hits	77	Shared Neighborhood Hits	60
SwissProt Accessions	P32848	Gene names	Pvalb, Pva
Domain Architecture
Description	Parvalbumin alpha.

PDCD6_MOUSE
NC score	0.120432 (rank : 144)	θ value	4.03905 (rank : 201)
Query Neighborhood Hits	238	Target Neighborhood Hits	142	Shared Neighborhood Hits	87
SwissProt Accessions	P12815, Q545I0, Q61145	Gene names	Pdcd6, Alg2
Domain Architecture
Description	Programmed cell death protein 6 (Probable calcium-binding protein ALG- 2) (PMP41) (ALG-257).

EFHD2_MOUSE
NC score	0.120174 (rank : 145)	θ value	0.279714 (rank : 139)
Query Neighborhood Hits	238	Target Neighborhood Hits	88	Shared Neighborhood Hits	60
SwissProt Accessions	Q9D8Y0, Q9D0P4	Gene names	Efhd2, Sws1
Domain Architecture
Description	EF-hand domain-containing protein 2 (Swiprosin-1).

PDCD6_HUMAN
NC score	0.120162 (rank : 146)	θ value	4.03905 (rank : 200)
Query Neighborhood Hits	238	Target Neighborhood Hits	141	Shared Neighborhood Hits	87
SwissProt Accessions	O75340	Gene names	PDCD6, ALG2
Domain Architecture
Description	Programmed cell death protein 6 (Probable calcium-binding protein ALG- 2).

KPCD3_HUMAN
NC score	0.119092 (rank : 147)	θ value	1.09739e-05 (rank : 46)
Query Neighborhood Hits	238	Target Neighborhood Hits	895	Shared Neighborhood Hits	68
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
NC score	0.117833 (rank : 148)	θ value	1.09739e-05 (rank : 47)
Query Neighborhood Hits	238	Target Neighborhood Hits	901	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

EFHD2_HUMAN
NC score	0.116609 (rank : 149)	θ value	0.365318 (rank : 142)
Query Neighborhood Hits	238	Target Neighborhood Hits	86	Shared Neighborhood Hits	59
SwissProt Accessions	Q96C19	Gene names	EFHD2, SWS1
Domain Architecture
Description	EF-hand domain-containing protein 2 (Swiprosin-1).

MRCKA_HUMAN
NC score	0.113919 (rank : 150)	θ value	3.19293e-05 (rank : 55)
Query Neighborhood Hits	238	Target Neighborhood Hits	1999	Shared Neighborhood Hits	69
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

KPCD1_MOUSE
NC score	0.113530 (rank : 151)	θ value	1.87187e-05 (rank : 52)
Query Neighborhood Hits	238	Target Neighborhood Hits	891	Shared Neighborhood Hits	68
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD2_HUMAN
NC score	0.112910 (rank : 152)	θ value	3.77169e-06 (rank : 42)
Query Neighborhood Hits	238	Target Neighborhood Hits	910	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KPCD1_HUMAN
NC score	0.112872 (rank : 153)	θ value	2.44474e-05 (rank : 54)
Query Neighborhood Hits	238	Target Neighborhood Hits	901	Shared Neighborhood Hits	68
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

MRCKB_MOUSE
NC score	0.110596 (rank : 154)	θ value	9.29e-05 (rank : 64)
Query Neighborhood Hits	238	Target Neighborhood Hits	2180	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PLSI_HUMAN
NC score	0.109111 (rank : 155)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	238	Target Neighborhood Hits	209	Shared Neighborhood Hits	98
SwissProt Accessions	Q14651	Gene names	PLS1
Domain Architecture
Description	Plastin-1 (I-plastin) (Intestine-specific plastin).

PRVA_HUMAN
NC score	0.108645 (rank : 156)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	238	Target Neighborhood Hits	63	Shared Neighborhood Hits	56
SwissProt Accessions	P20472, P78378, Q4VB78, Q5R3Q9	Gene names	PVALB
Domain Architecture	No domain graphic available
Description	Parvalbumin alpha.

MRCKB_HUMAN
NC score	0.108283 (rank : 157)	θ value	5.44631e-05 (rank : 61)
Query Neighborhood Hits	238	Target Neighborhood Hits	2239	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PCAT1_HUMAN
NC score	0.102026 (rank : 158)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	238	Target Neighborhood Hits	80	Shared Neighborhood Hits	59
SwissProt Accessions	Q8NF37, Q1HAQ1, Q7Z4G6, Q8N3U7, Q8WUL8, Q9GZW6	Gene names	AYTL2, LPCAT1, PFAAP3
Domain Architecture	No domain graphic available
Description	1-acylglycerophosphocholine O-acyltransferase 1 (EC 2.3.1.23) (Lung- type acyl-coa:lysophosphatidylcholine acyltransferase 1) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3).

PCAT1_MOUSE
NC score	0.099104 (rank : 159)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	238	Target Neighborhood Hits	78	Shared Neighborhood Hits	59
SwissProt Accessions	Q3TFD2, Q3TAX4, Q6NXZ6, Q8BG23, Q8BUX7, Q99JU6	Gene names	Aytl2, Lpcat1
Domain Architecture	No domain graphic available
Description	1-acylglycerophosphocholine O-acyltransferase 1 (EC 2.3.1.23) (Lung- type acyl-coa:lysophosphatidylcholine acyltransferase 1) (mLPCAT1) (Acyltransferase-like 2).

RASF5_MOUSE
NC score	0.098904 (rank : 160)	θ value	0.279714 (rank : 141)
Query Neighborhood Hits	238	Target Neighborhood Hits	72	Shared Neighborhood Hits	47
SwissProt Accessions	Q5EBH1, O70407, Q6KAR0, Q8C2E8	Gene names	Rassf5, Nore1, Rapl
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

VAV2_HUMAN
NC score	0.096917 (rank : 161)	θ value	0.0736092 (rank : 125)
Query Neighborhood Hits	238	Target Neighborhood Hits	453	Shared Neighborhood Hits	61
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

RPKL1_HUMAN
NC score	0.095652 (rank : 162)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	238	Target Neighborhood Hits	708	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

RPKL1_MOUSE
NC score	0.095602 (rank : 163)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	238	Target Neighborhood Hits	704	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

NUCB2_HUMAN
NC score	0.095228 (rank : 164)	θ value	0.0736092 (rank : 123)
Query Neighborhood Hits	238	Target Neighborhood Hits	321	Shared Neighborhood Hits	50
SwissProt Accessions	P80303, Q8NFT5	Gene names	NUCB2, NEFA
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA) (Gastric cancer antigen Zg4).

NUCB2_MOUSE
NC score	0.094823 (rank : 165)	θ value	0.0330416 (rank : 109)
Query Neighborhood Hits	238	Target Neighborhood Hits	459	Shared Neighborhood Hits	52
SwissProt Accessions	P81117	Gene names	Nucb2, Nefa
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA).

PLSL_MOUSE
NC score	0.094113 (rank : 166)	θ value	0.125558 (rank : 130)
Query Neighborhood Hits	238	Target Neighborhood Hits	170	Shared Neighborhood Hits	81
SwissProt Accessions	Q61233, Q3UE24, Q8R1X3, Q9CV77	Gene names	Lcp1, Pls2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (pp65).

PLSL_HUMAN
NC score	0.092785 (rank : 167)	θ value	0.163984 (rank : 134)
Query Neighborhood Hits	238	Target Neighborhood Hits	168	Shared Neighborhood Hits	82
SwissProt Accessions	P13796	Gene names	LCP1, PLS2
Domain Architecture
Description	Plastin-2 (L-plastin) (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P).

GPDM_HUMAN
NC score	0.092544 (rank : 168)	θ value	0.47712 (rank : 146)
Query Neighborhood Hits	238	Target Neighborhood Hits	116	Shared Neighborhood Hits	68
SwissProt Accessions	P43304, Q59FR1, Q9HAP9	Gene names	GPD2
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M) (mtGPD).

VAV2_MOUSE
NC score	0.092026 (rank : 169)	θ value	0.0736092 (rank : 126)
Query Neighborhood Hits	238	Target Neighborhood Hits	456	Shared Neighborhood Hits	58
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

KS6C1_MOUSE
NC score	0.091582 (rank : 170)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	238	Target Neighborhood Hits	700	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

DMPK_MOUSE
NC score	0.091421 (rank : 171)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	238	Target Neighborhood Hits	908	Shared Neighborhood Hits	35
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

DMPK_HUMAN
NC score	0.091244 (rank : 172)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	238	Target Neighborhood Hits	944	Shared Neighborhood Hits	35
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

RASF5_HUMAN
NC score	0.091193 (rank : 173)	θ value	5.27518 (rank : 214)
Query Neighborhood Hits	238	Target Neighborhood Hits	79	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WWW0, Q5SY32, Q8WWV9, Q8WXF4, Q9BT99	Gene names	RASSF5, NORE1, RAPL
Domain Architecture	No domain graphic available
Description	Ras association domain-containing family protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL).

KS6C1_HUMAN
NC score	0.089366 (rank : 174)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	238	Target Neighborhood Hits	682	Shared Neighborhood Hits	35
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

PKN1_MOUSE
NC score	0.088026 (rank : 175)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	35
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN1_HUMAN
NC score	0.087915 (rank : 176)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

PKN3_HUMAN
NC score	0.087798 (rank : 177)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	238	Target Neighborhood Hits	893	Shared Neighborhood Hits	36
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

AKT1_HUMAN
NC score	0.087753 (rank : 178)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	238	Target Neighborhood Hits	885	Shared Neighborhood Hits	38
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
NC score	0.087566 (rank : 179)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	238	Target Neighborhood Hits	878	Shared Neighborhood Hits	37
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

PKN2_HUMAN
NC score	0.087373 (rank : 180)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	238	Target Neighborhood Hits	892	Shared Neighborhood Hits	35
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
NC score	0.087197 (rank : 181)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

SGK2_HUMAN
NC score	0.086917 (rank : 182)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

PKN3_MOUSE
NC score	0.086263 (rank : 183)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	238	Target Neighborhood Hits	1009	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

SGK2_MOUSE
NC score	0.086129 (rank : 184)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	238	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

SGK3_HUMAN
NC score	0.085921 (rank : 185)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	238	Target Neighborhood Hits	877	Shared Neighborhood Hits	35
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK1_MOUSE
NC score	0.085841 (rank : 186)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	238	Target Neighborhood Hits	848	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK3_MOUSE
NC score	0.085660 (rank : 187)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	238	Target Neighborhood Hits	882	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

AKT2_MOUSE
NC score	0.085605 (rank : 188)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	238	Target Neighborhood Hits	875	Shared Neighborhood Hits	36
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

SGK1_HUMAN
NC score	0.085592 (rank : 189)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	238	Target Neighborhood Hits	848	Shared Neighborhood Hits	35
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

LATS2_MOUSE
NC score	0.085540 (rank : 190)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	238	Target Neighborhood Hits	879	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

AKT2_HUMAN
NC score	0.085520 (rank : 191)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	238	Target Neighborhood Hits	878	Shared Neighborhood Hits	36
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

LATS1_MOUSE
NC score	0.085282 (rank : 192)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	238	Target Neighborhood Hits	1027	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

AKT3_MOUSE
NC score	0.085204 (rank : 193)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

LATS1_HUMAN
NC score	0.085188 (rank : 194)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	238	Target Neighborhood Hits	1057	Shared Neighborhood Hits	35
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

AKT3_HUMAN
NC score	0.085184 (rank : 195)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

ST38L_MOUSE
NC score	0.085029 (rank : 196)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	238	Target Neighborhood Hits	821	Shared Neighborhood Hits	36
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

LATS2_HUMAN
NC score	0.084853 (rank : 197)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

VAV_HUMAN
NC score	0.084797 (rank : 198)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	238	Target Neighborhood Hits	452	Shared Neighborhood Hits	63
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

EFHB_HUMAN
NC score	0.084396 (rank : 199)	θ value	4.03905 (rank : 198)
Query Neighborhood Hits	238	Target Neighborhood Hits	125	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N7U6, Q6ZWK9, Q8IV58, Q96LQ6	Gene names	EFHB
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member B.

ST38L_HUMAN
NC score	0.084303 (rank : 200)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

STK38_HUMAN
NC score	0.084092 (rank : 201)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
NC score	0.084023 (rank : 202)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

GRK4_MOUSE
NC score	0.083325 (rank : 203)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	238	Target Neighborhood Hits	808	Shared Neighborhood Hits	35
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

GRK4_HUMAN
NC score	0.083199 (rank : 204)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	238	Target Neighborhood Hits	822	Shared Neighborhood Hits	35
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

ARBK1_HUMAN
NC score	0.083024 (rank : 205)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	238	Target Neighborhood Hits	859	Shared Neighborhood Hits	37
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
NC score	0.083010 (rank : 206)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	37
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

GRK7_HUMAN
NC score	0.082670 (rank : 207)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	238	Target Neighborhood Hits	820	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

ARBK2_HUMAN
NC score	0.082642 (rank : 208)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

KS6A5_MOUSE
NC score	0.082517 (rank : 209)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	238	Target Neighborhood Hits	854	Shared Neighborhood Hits	36
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

RK_HUMAN
NC score	0.082285 (rank : 210)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	238	Target Neighborhood Hits	835	Shared Neighborhood Hits	35
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

PLST_HUMAN
NC score	0.081710 (rank : 211)	θ value	8.99809 (rank : 233)
Query Neighborhood Hits	238	Target Neighborhood Hits	161	Shared Neighborhood Hits	79
SwissProt Accessions	P13797, Q86YI6	Gene names	PLS3
Domain Architecture
Description	Plastin-3 (T-plastin).

GRK5_HUMAN
NC score	0.081501 (rank : 212)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	238	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KS6B2_MOUSE
NC score	0.081473 (rank : 213)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	238	Target Neighborhood Hits	871	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

GRK5_MOUSE
NC score	0.081407 (rank : 214)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	238	Target Neighborhood Hits	823	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KS6B1_MOUSE
NC score	0.080953 (rank : 215)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.080949 (rank : 216)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B2_HUMAN
NC score	0.080894 (rank : 217)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

KS6A4_HUMAN
NC score	0.080868 (rank : 218)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	238	Target Neighborhood Hits	868	Shared Neighborhood Hits	35
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

VAV_MOUSE
NC score	0.080802 (rank : 219)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	238	Target Neighborhood Hits	430	Shared Neighborhood Hits	61
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

GRK6_MOUSE
NC score	0.080796 (rank : 220)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	238	Target Neighborhood Hits	820	Shared Neighborhood Hits	35
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KS6A4_MOUSE
NC score	0.080695 (rank : 221)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	238	Target Neighborhood Hits	866	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

GRK6_HUMAN
NC score	0.080340 (rank : 222)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	238	Target Neighborhood Hits	823	Shared Neighborhood Hits	37
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KAPCB_MOUSE
NC score	0.080319 (rank : 223)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	238	Target Neighborhood Hits	836	Shared Neighborhood Hits	35
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_HUMAN
NC score	0.080153 (rank : 224)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	238	Target Neighborhood Hits	837	Shared Neighborhood Hits	35
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCA_MOUSE
NC score	0.079897 (rank : 225)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	238	Target Neighborhood Hits	836	Shared Neighborhood Hits	35
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

MLRN_HUMAN
NC score	0.079706 (rank : 226)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	238	Target Neighborhood Hits	107	Shared Neighborhood Hits	59
SwissProt Accessions	P24844, Q9H136	Gene names	MYL9, MLC2, MRLC1, MYRL2
Domain Architecture
Description	Myosin regulatory light chain 2, smooth muscle isoform (Myosin RLC) (Myosin regulatory light chain 9) (LC20).

KAPCA_HUMAN
NC score	0.079655 (rank : 227)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

RK_MOUSE
NC score	0.079625 (rank : 228)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	238	Target Neighborhood Hits	829	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

MAST1_HUMAN
NC score	0.079469 (rank : 229)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	238	Target Neighborhood Hits	1146	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MAST1_MOUSE
NC score	0.079343 (rank : 230)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	238	Target Neighborhood Hits	1123	Shared Neighborhood Hits	38
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KS6A5_HUMAN
NC score	0.079293 (rank : 231)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	238	Target Neighborhood Hits	855	Shared Neighborhood Hits	36
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

MAST3_HUMAN
NC score	0.078840 (rank : 232)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	238	Target Neighborhood Hits	1128	Shared Neighborhood Hits	38
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

MLRN_MOUSE
NC score	0.078484 (rank : 233)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	238	Target Neighborhood Hits	106	Shared Neighborhood Hits	59
SwissProt Accessions	Q9CQ19, Q80X77	Gene names	Myl9, Myrl2
Domain Architecture
Description	Myosin regulatory light chain 2, smooth muscle isoform (Myosin RLC) (Myosin regulatory light chain 9).

MLRM_HUMAN
NC score	0.078359 (rank : 234)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	238	Target Neighborhood Hits	111	Shared Neighborhood Hits	61
SwissProt Accessions	P19105	Gene names	MRLC2, MLCB, RLC
Domain Architecture
Description	Myosin regulatory light chain 2, nonsarcomeric (Myosin RLC).

ST32C_HUMAN
NC score	0.077941 (rank : 235)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	238	Target Neighborhood Hits	832	Shared Neighborhood Hits	35
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

MAST2_MOUSE
NC score	0.077527 (rank : 236)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	238	Target Neighborhood Hits	1110	Shared Neighborhood Hits	37
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

ST32C_MOUSE
NC score	0.077495 (rank : 237)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	35
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

MAST2_HUMAN
NC score	0.077486 (rank : 238)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	238	Target Neighborhood Hits	1189	Shared Neighborhood Hits	38
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

PRKX_MOUSE
NC score	0.077427 (rank : 239)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	238	Target Neighborhood Hits	846	Shared Neighborhood Hits	35
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

KAPCG_HUMAN
NC score	0.077355 (rank : 240)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	238	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KGP1A_HUMAN
NC score	0.077352 (rank : 241)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	238	Target Neighborhood Hits	901	Shared Neighborhood Hits	35
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_MOUSE
NC score	0.077295 (rank : 242)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	238	Target Neighborhood Hits	922	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

MASTL_HUMAN
NC score	0.077283 (rank : 243)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	238	Target Neighborhood Hits	894	Shared Neighborhood Hits	35
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

PRKX_HUMAN
NC score	0.077281 (rank : 244)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

KGP1B_HUMAN
NC score	0.077274 (rank : 245)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	238	Target Neighborhood Hits	921	Shared Neighborhood Hits	35
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

MASTL_MOUSE
NC score	0.076905 (rank : 246)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	238	Target Neighborhood Hits	862	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

ST32B_HUMAN
NC score	0.076641 (rank : 247)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

RAF1_MOUSE
NC score	0.076634 (rank : 248)	θ value	0.0148317 (rank : 104)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	62
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MAST4_HUMAN
NC score	0.076371 (rank : 249)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	238	Target Neighborhood Hits	1804	Shared Neighborhood Hits	40
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

VAV3_HUMAN
NC score	0.076274 (rank : 250)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	238	Target Neighborhood Hits	398	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.076148 (rank : 251)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	238	Target Neighborhood Hits	404	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ST32B_MOUSE
NC score	0.076096 (rank : 252)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

RAF1_HUMAN
NC score	0.076002 (rank : 253)	θ value	0.0148317 (rank : 103)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	62
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RCN2_MOUSE
NC score	0.075906 (rank : 254)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	238	Target Neighborhood Hits	108	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BP92, O70341	Gene names	Rcn2
Domain Architecture	No domain graphic available
Description	Reticulocalbin-2 precursor (Taipoxin-associated calcium-binding protein 49) (TCBP-49).

ST32A_HUMAN
NC score	0.075374 (rank : 255)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	238	Target Neighborhood Hits	834	Shared Neighborhood Hits	35
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

CTRO_HUMAN
NC score	0.074898 (rank : 256)	θ value	1.81305 (rank : 177)
Query Neighborhood Hits	238	Target Neighborhood Hits	2092	Shared Neighborhood Hits	56
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

KGP2_MOUSE
NC score	0.074800 (rank : 257)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	238	Target Neighborhood Hits	1029	Shared Neighborhood Hits	37
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KGP2_HUMAN
NC score	0.074471 (rank : 258)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	238	Target Neighborhood Hits	1023	Shared Neighborhood Hits	36
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

ST32A_MOUSE
NC score	0.074367 (rank : 259)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	238	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

KS6A6_HUMAN
NC score	0.074112 (rank : 260)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	238	Target Neighborhood Hits	853	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

ROCK2_HUMAN
NC score	0.073801 (rank : 261)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	238	Target Neighborhood Hits	2073	Shared Neighborhood Hits	53
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

KS6A1_MOUSE
NC score	0.073721 (rank : 262)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A1_HUMAN
NC score	0.073705 (rank : 263)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	238	Target Neighborhood Hits	854	Shared Neighborhood Hits	35
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

GPDM_MOUSE
NC score	0.073611 (rank : 264)	θ value	1.81305 (rank : 179)
Query Neighborhood Hits	238	Target Neighborhood Hits	101	Shared Neighborhood Hits	51
SwissProt Accessions	Q64521, Q61507	Gene names	Gpd2, Gdm1
Domain Architecture
Description	Glycerol-3-phosphate dehydrogenase, mitochondrial precursor (EC 1.1.99.5) (GPD-M) (GPDH-M).

ROCK2_MOUSE
NC score	0.073606 (rank : 265)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	238	Target Neighborhood Hits	2072	Shared Neighborhood Hits	51
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

KS6A3_MOUSE
NC score	0.073549 (rank : 266)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	238	Target Neighborhood Hits	860	Shared Neighborhood Hits	35
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.073538 (rank : 267)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	238	Target Neighborhood Hits	859	Shared Neighborhood Hits	35
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A2_HUMAN
NC score	0.073376 (rank : 268)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	238	Target Neighborhood Hits	857	Shared Neighborhood Hits	35
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

F5006_HUMAN
NC score	0.073335 (rank : 269)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	238	Target Neighborhood Hits	794	Shared Neighborhood Hits	35
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

ROCK1_HUMAN
NC score	0.073270 (rank : 270)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	238	Target Neighborhood Hits	2000	Shared Neighborhood Hits	52
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

PDPK1_MOUSE
NC score	0.073260 (rank : 271)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	238	Target Neighborhood Hits	852	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

F5006_MOUSE
NC score	0.073132 (rank : 272)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	238	Target Neighborhood Hits	793	Shared Neighborhood Hits	35
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

PDPK1_HUMAN
NC score	0.073077 (rank : 273)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	238	Target Neighborhood Hits	851	Shared Neighborhood Hits	35
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

KS6A2_MOUSE
NC score	0.073013 (rank : 274)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

PRKY_HUMAN
NC score	0.072845 (rank : 275)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	238	Target Neighborhood Hits	844	Shared Neighborhood Hits	35
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

EFCB2_MOUSE
NC score	0.072568 (rank : 276)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	238	Target Neighborhood Hits	64	Shared Neighborhood Hits	32
SwissProt Accessions	Q9CQ46, Q9CS07	Gene names	Efcab2
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 2.

PLST_MOUSE
NC score	0.072436 (rank : 277)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	238	Target Neighborhood Hits	156	Shared Neighborhood Hits	78
SwissProt Accessions	Q99K51	Gene names	Pls3
Domain Architecture	No domain graphic available
Description	Plastin-3 (T-plastin).

CTRO_MOUSE
NC score	0.071526 (rank : 278)	θ value	1.81305 (rank : 178)
Query Neighborhood Hits	238	Target Neighborhood Hits	2344	Shared Neighborhood Hits	56
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ROCK1_MOUSE
NC score	0.071407 (rank : 279)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	238	Target Neighborhood Hits	2126	Shared Neighborhood Hits	52
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

STK40_MOUSE
NC score	0.070794 (rank : 280)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	238	Target Neighborhood Hits	751	Shared Neighborhood Hits	35
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STK40_HUMAN
NC score	0.070555 (rank : 281)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	238	Target Neighborhood Hits	751	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

TRIB3_HUMAN
NC score	0.069775 (rank : 282)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	238	Target Neighborhood Hits	519	Shared Neighborhood Hits	30
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

RGNEF_MOUSE
NC score	0.069309 (rank : 283)	θ value	4.03905 (rank : 203)
Query Neighborhood Hits	238	Target Neighborhood Hits	641	Shared Neighborhood Hits	63
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ARAF_MOUSE
NC score	0.068922 (rank : 284)	θ value	0.125558 (rank : 129)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	58
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

EFCB2_HUMAN
NC score	0.068887 (rank : 285)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	238	Target Neighborhood Hits	73	Shared Neighborhood Hits	34
SwissProt Accessions	Q5VUJ9, Q59G23, Q9BS36	Gene names	EFCAB2
Domain Architecture	No domain graphic available
Description	EF-hand calcium-binding domain-containing protein 2.

ULK4_MOUSE
NC score	0.068818 (rank : 286)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	238	Target Neighborhood Hits	793	Shared Neighborhood Hits	35
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

MYO9B_MOUSE
NC score	0.068400 (rank : 287)	θ value	0.0113563 (rank : 99)
Query Neighborhood Hits	238	Target Neighborhood Hits	311	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.068296 (rank : 288)	θ value	0.00509761 (rank : 93)
Query Neighborhood Hits	238	Target Neighborhood Hits	641	Shared Neighborhood Hits	56
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

TRIB1_HUMAN
NC score	0.068290 (rank : 289)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	238	Target Neighborhood Hits	598	Shared Neighborhood Hits	34
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

BRAF1_HUMAN
NC score	0.067682 (rank : 290)	θ value	0.0961366 (rank : 127)
Query Neighborhood Hits	238	Target Neighborhood Hits	883	Shared Neighborhood Hits	60
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

TRIB3_MOUSE
NC score	0.067660 (rank : 291)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	238	Target Neighborhood Hits	578	Shared Neighborhood Hits	30
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

TRIB1_MOUSE
NC score	0.067444 (rank : 292)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	238	Target Neighborhood Hits	593	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

ARAF_HUMAN
NC score	0.067341 (rank : 293)	θ value	0.125558 (rank : 128)
Query Neighborhood Hits	238	Target Neighborhood Hits	924	Shared Neighborhood Hits	60
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

2ACA_HUMAN
NC score	0.066537 (rank : 294)	θ value	0.00665767 (rank : 94)
Query Neighborhood Hits	238	Target Neighborhood Hits	100	Shared Neighborhood Hits	6
SwissProt Accessions	Q06190, Q06189, Q9NPQ5	Gene names	PPP2R3A, PPP2R3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B (PP2A, subunit B, B''-PR72/PR130) (PP2A, subunit B, B72/B130 isoforms) (PP2A, subunit B, PR72/PR130 isoforms) (PP2A, subunit B, R3 isoform).

MKNK1_HUMAN
NC score	0.066021 (rank : 295)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	238	Target Neighborhood Hits	701	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

TRIB2_HUMAN
NC score	0.064871 (rank : 296)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	238	Target Neighborhood Hits	657	Shared Neighborhood Hits	35
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
NC score	0.064765 (rank : 297)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	238	Target Neighborhood Hits	653	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

MKNK1_MOUSE
NC score	0.064539 (rank : 298)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	238	Target Neighborhood Hits	811	Shared Neighborhood Hits	35
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

AURKB_MOUSE
NC score	0.064383 (rank : 299)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

AURKC_MOUSE
NC score	0.064369 (rank : 300)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	238	Target Neighborhood Hits	844	Shared Neighborhood Hits	35
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

AURKC_HUMAN
NC score	0.064290 (rank : 301)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

ST17A_HUMAN
NC score	0.064288 (rank : 302)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

RGAP1_MOUSE
NC score	0.064208 (rank : 303)	θ value	5.27518 (rank : 215)
Query Neighborhood Hits	238	Target Neighborhood Hits	185	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

KCC1D_HUMAN
NC score	0.063959 (rank : 304)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	238	Target Neighborhood Hits	846	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
NC score	0.063952 (rank : 305)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

NUAK2_MOUSE
NC score	0.063850 (rank : 306)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	238	Target Neighborhood Hits	878	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

AURKB_HUMAN
NC score	0.063798 (rank : 307)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

PINK1_MOUSE
NC score	0.063467 (rank : 308)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	238	Target Neighborhood Hits	726	Shared Neighborhood Hits	35
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

SBK1_HUMAN
NC score	0.063433 (rank : 309)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

ST17B_HUMAN
NC score	0.063421 (rank : 310)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	238	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

PIM2_MOUSE
NC score	0.063414 (rank : 311)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	238	Target Neighborhood Hits	809	Shared Neighborhood Hits	35
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

TSSK4_MOUSE
NC score	0.063327 (rank : 312)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK1_HUMAN
NC score	0.063291 (rank : 313)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

DCAK3_HUMAN
NC score	0.063276 (rank : 314)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	35
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

KPSH2_HUMAN
NC score	0.063268 (rank : 315)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	238	Target Neighborhood Hits	822	Shared Neighborhood Hits	35
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

TSSK2_MOUSE
NC score	0.063236 (rank : 316)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	238	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

HUNK_HUMAN
NC score	0.063236 (rank : 317)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

MKNK2_MOUSE
NC score	0.063201 (rank : 318)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	238	Target Neighborhood Hits	819	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

PLK1_MOUSE
NC score	0.063148 (rank : 319)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

TSSK4_HUMAN
NC score	0.063123 (rank : 320)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	238	Target Neighborhood Hits	836	Shared Neighborhood Hits	35
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

HUNK_MOUSE
NC score	0.063060 (rank : 321)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

PLK1_HUMAN
NC score	0.063047 (rank : 322)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

DCAK3_MOUSE
NC score	0.063023 (rank : 323)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	238	Target Neighborhood Hits	922	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

MKNK2_HUMAN
NC score	0.062982 (rank : 324)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	238	Target Neighborhood Hits	821	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

SBK1_MOUSE
NC score	0.062917 (rank : 325)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	35
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

RCN2_HUMAN
NC score	0.062912 (rank : 326)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	238	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q14257	Gene names	RCN2, ERC55
Domain Architecture
Description	Reticulocalbin-2 precursor (Calcium-binding protein ERC-55) (E6- binding protein) (E6BP).

KCC1B_HUMAN
NC score	0.062876 (rank : 327)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	238	Target Neighborhood Hits	842	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC4_MOUSE
NC score	0.062825 (rank : 328)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC1B_MOUSE
NC score	0.062813 (rank : 329)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	238	Target Neighborhood Hits	842	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1G_MOUSE
NC score	0.062722 (rank : 330)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	238	Target Neighborhood Hits	851	Shared Neighborhood Hits	35
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC4_HUMAN
NC score	0.062701 (rank : 331)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	238	Target Neighborhood Hits	841	Shared Neighborhood Hits	35
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

MLR5_HUMAN
NC score	0.062674 (rank : 332)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	238	Target Neighborhood Hits	90	Shared Neighborhood Hits	51
SwissProt Accessions	Q02045	Gene names	MYL5
Domain Architecture
Description	Superfast myosin regulatory light chain 2 (MyLC-2) (MYLC2) (Myosin regulatory light chain 5).

KCC1G_HUMAN
NC score	0.062574 (rank : 333)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1A_HUMAN
NC score	0.062486 (rank : 334)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	238	Target Neighborhood Hits	846	Shared Neighborhood Hits	35
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

TSSK2_HUMAN
NC score	0.062436 (rank : 335)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	238	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

MAPK5_HUMAN
NC score	0.062366 (rank : 336)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	238	Target Neighborhood Hits	795	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
NC score	0.062361 (rank : 337)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	238	Target Neighborhood Hits	799	Shared Neighborhood Hits	35
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

KKCC1_MOUSE
NC score	0.062305 (rank : 338)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	238	Target Neighborhood Hits	866	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

NUAK2_HUMAN
NC score	0.062260 (rank : 339)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

KCC1A_MOUSE
NC score	0.062241 (rank : 340)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	238	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

PIM2_HUMAN
NC score	0.062208 (rank : 341)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	238	Target Neighborhood Hits	808	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

AAPK2_HUMAN
NC score	0.062205 (rank : 342)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	36
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

ST17B_MOUSE
NC score	0.062109 (rank : 343)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

STK6_HUMAN
NC score	0.062071 (rank : 344)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	238	Target Neighborhood Hits	916	Shared Neighborhood Hits	36
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

AAPK1_MOUSE
NC score	0.062041 (rank : 345)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	35
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

STK6_MOUSE
NC score	0.061975 (rank : 346)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	35
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

NIM1_HUMAN
NC score	0.061893 (rank : 347)	θ value	θ > 10 (rank : 470)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PIM3_MOUSE
NC score	0.061756 (rank : 348)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	238	Target Neighborhood Hits	783	Shared Neighborhood Hits	35
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

AAPK1_HUMAN
NC score	0.061697 (rank : 349)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	238	Target Neighborhood Hits	842	Shared Neighborhood Hits	35
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KKCC1_HUMAN
NC score	0.061592 (rank : 350)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MLRA_MOUSE
NC score	0.061541 (rank : 351)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	238	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	Q9QVP4, Q63977, Q9JIE8	Gene names	Myl7, Mylc2a
Domain Architecture
Description	Myosin regulatory light chain 2, atrial isoform (Myosin light chain 2a) (MLC-2a) (MLC2a) (Myosin regulatory light chain 7).

MYL6B_HUMAN
NC score	0.061541 (rank : 352)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	238	Target Neighborhood Hits	78	Shared Neighborhood Hits	36
SwissProt Accessions	P14649	Gene names	MYL6B, MLC1SA
Domain Architecture
Description	Myosin light polypeptide 6B (Smooth muscle and nonmuscle myosin light chain alkali 6B) (Myosin light chain 1 slow-twitch muscle A isoform) (MLC1sa).

MELK_MOUSE
NC score	0.061435 (rank : 353)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	238	Target Neighborhood Hits	860	Shared Neighborhood Hits	35
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

MELK_HUMAN
NC score	0.061427 (rank : 354)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	238	Target Neighborhood Hits	847	Shared Neighborhood Hits	35
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

RGAP1_HUMAN
NC score	0.061409 (rank : 355)	θ value	4.03905 (rank : 202)
Query Neighborhood Hits	238	Target Neighborhood Hits	189	Shared Neighborhood Hits	42
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

KPSH1_HUMAN
NC score	0.061383 (rank : 356)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	238	Target Neighborhood Hits	842	Shared Neighborhood Hits	36
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

NIM1_MOUSE
NC score	0.061378 (rank : 357)	θ value	θ > 10 (rank : 471)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PIM3_HUMAN
NC score	0.061374 (rank : 358)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	238	Target Neighborhood Hits	789	Shared Neighborhood Hits	35
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

KPSH1_MOUSE
NC score	0.061224 (rank : 359)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	238	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

MARK4_HUMAN
NC score	0.060924 (rank : 360)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	37
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

M3K14_HUMAN
NC score	0.060877 (rank : 361)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	238	Target Neighborhood Hits	887	Shared Neighborhood Hits	35
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

PLK4_MOUSE
NC score	0.060862 (rank : 362)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	238	Target Neighborhood Hits	879	Shared Neighborhood Hits	35
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PMYT1_HUMAN
NC score	0.060830 (rank : 363)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	238	Target Neighborhood Hits	814	Shared Neighborhood Hits	35
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PASK_HUMAN
NC score	0.060807 (rank : 364)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	238	Target Neighborhood Hits	857	Shared Neighborhood Hits	35
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

STK33_HUMAN
NC score	0.060803 (rank : 365)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	238	Target Neighborhood Hits	879	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

PASK_MOUSE
NC score	0.060762 (rank : 366)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PLK4_HUMAN
NC score	0.060751 (rank : 367)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

MARK2_MOUSE
NC score	0.060734 (rank : 368)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	238	Target Neighborhood Hits	1018	Shared Neighborhood Hits	36
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MARK4_MOUSE
NC score	0.060673 (rank : 369)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	238	Target Neighborhood Hits	898	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

NUAK1_HUMAN
NC score	0.060656 (rank : 370)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

NUAK1_MOUSE
NC score	0.060655 (rank : 371)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	238	Target Neighborhood Hits	881	Shared Neighborhood Hits	35
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NEK3_MOUSE
NC score	0.060592 (rank : 372)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	238	Target Neighborhood Hits	854	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

PPE2_HUMAN
NC score	0.060555 (rank : 373)	θ value	0.47712 (rank : 147)
Query Neighborhood Hits	238	Target Neighborhood Hits	106	Shared Neighborhood Hits	58
SwissProt Accessions	O14830, O14831	Gene names	PPEF2
Domain Architecture
Description	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2).

M3K14_MOUSE
NC score	0.060527 (rank : 374)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	238	Target Neighborhood Hits	889	Shared Neighborhood Hits	36
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

PLK2_HUMAN
NC score	0.060508 (rank : 375)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	238	Target Neighborhood Hits	854	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MARK3_HUMAN
NC score	0.060500 (rank : 376)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	238	Target Neighborhood Hits	893	Shared Neighborhood Hits	36
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

CHK2_HUMAN
NC score	0.060416 (rank : 377)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	238	Target Neighborhood Hits	859	Shared Neighborhood Hits	35
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

CHK2_MOUSE
NC score	0.060406 (rank : 378)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	238	Target Neighborhood Hits	860	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

BRSK1_HUMAN
NC score	0.060403 (rank : 379)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	238	Target Neighborhood Hits	942	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

CAMKV_HUMAN
NC score	0.060365 (rank : 380)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	238	Target Neighborhood Hits	1084	Shared Neighborhood Hits	37
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

PLK2_MOUSE
NC score	0.060311 (rank : 381)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

MARK1_MOUSE
NC score	0.060266 (rank : 382)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	238	Target Neighborhood Hits	886	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

CAMKV_MOUSE
NC score	0.060194 (rank : 383)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	238	Target Neighborhood Hits	848	Shared Neighborhood Hits	36
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

PHKG1_MOUSE
NC score	0.060135 (rank : 384)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

MARK3_MOUSE
NC score	0.060123 (rank : 385)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	238	Target Neighborhood Hits	919	Shared Neighborhood Hits	37
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK2_HUMAN
NC score	0.060092 (rank : 386)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	238	Target Neighborhood Hits	1056	Shared Neighborhood Hits	36
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MARK1_HUMAN
NC score	0.060056 (rank : 387)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	238	Target Neighborhood Hits	887	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

PMYT1_MOUSE
NC score	0.059995 (rank : 388)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	238	Target Neighborhood Hits	910	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KKCC2_HUMAN
NC score	0.059867 (rank : 389)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	238	Target Neighborhood Hits	852	Shared Neighborhood Hits	35
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
NC score	0.059858 (rank : 390)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	238	Target Neighborhood Hits	855	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

BRSK2_HUMAN
NC score	0.059740 (rank : 391)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	238	Target Neighborhood Hits	897	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

MAPK2_HUMAN
NC score	0.059644 (rank : 392)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	238	Target Neighborhood Hits	844	Shared Neighborhood Hits	35
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

RIPK5_MOUSE
NC score	0.059622 (rank : 393)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

MAPK3_HUMAN
NC score	0.059530 (rank : 394)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	238	Target Neighborhood Hits	807	Shared Neighborhood Hits	35
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

RIPK5_HUMAN
NC score	0.059497 (rank : 395)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	238	Target Neighborhood Hits	864	Shared Neighborhood Hits	35
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

MAPK3_MOUSE
NC score	0.059372 (rank : 396)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	238	Target Neighborhood Hits	811	Shared Neighborhood Hits	35
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAPK2_MOUSE
NC score	0.059284 (rank : 397)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	238	Target Neighborhood Hits	831	Shared Neighborhood Hits	35
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

NEK3_HUMAN
NC score	0.059283 (rank : 398)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	238	Target Neighborhood Hits	865	Shared Neighborhood Hits	35
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

PLK3_HUMAN
NC score	0.059267 (rank : 399)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	238	Target Neighborhood Hits	865	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

TSSK1_MOUSE
NC score	0.059245 (rank : 400)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	238	Target Neighborhood Hits	835	Shared Neighborhood Hits	35
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

PIM1_MOUSE
NC score	0.059238 (rank : 401)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	238	Target Neighborhood Hits	787	Shared Neighborhood Hits	35
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

K0999_HUMAN
NC score	0.059206 (rank : 402)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

TSSK6_HUMAN
NC score	0.059177 (rank : 403)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

K0999_MOUSE
NC score	0.059166 (rank : 404)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	238	Target Neighborhood Hits	931	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

PHKG1_HUMAN
NC score	0.059158 (rank : 405)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

NUCB1_MOUSE
NC score	0.059011 (rank : 406)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	238	Target Neighborhood Hits	414	Shared Neighborhood Hits	36
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

DCAK2_HUMAN
NC score	0.059002 (rank : 407)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	238	Target Neighborhood Hits	862	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DAPK2_MOUSE
NC score	0.058827 (rank : 408)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	238	Target Neighborhood Hits	834	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MYLK2_HUMAN
NC score	0.058745 (rank : 409)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	238	Target Neighborhood Hits	920	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

ULK3_MOUSE
NC score	0.058743 (rank : 410)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PHKG2_HUMAN
NC score	0.058713 (rank : 411)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	238	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

SN1L1_HUMAN
NC score	0.058680 (rank : 412)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	238	Target Neighborhood Hits	911	Shared Neighborhood Hits	37
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

PLK3_MOUSE
NC score	0.058631 (rank : 413)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	238	Target Neighborhood Hits	863	Shared Neighborhood Hits	35
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

PHKG2_MOUSE
NC score	0.058572 (rank : 414)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	238	Target Neighborhood Hits	841	Shared Neighborhood Hits	35
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

SNRK_HUMAN
NC score	0.058570 (rank : 415)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	238	Target Neighborhood Hits	855	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SN1L2_MOUSE
NC score	0.058545 (rank : 416)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	238	Target Neighborhood Hits	944	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

DCAK2_MOUSE
NC score	0.058438 (rank : 417)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

STK11_HUMAN
NC score	0.058417 (rank : 418)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	238	Target Neighborhood Hits	831	Shared Neighborhood Hits	35
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

NUCB1_HUMAN
NC score	0.058302 (rank : 419)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	238	Target Neighborhood Hits	359	Shared Neighborhood Hits	34
SwissProt Accessions	Q02818, Q15838, Q7Z4J7, Q9BUR1	Gene names	NUCB1, NUC
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

TSSK6_MOUSE
NC score	0.058232 (rank : 420)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	238	Target Neighborhood Hits	824	Shared Neighborhood Hits	35
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PDK1L_HUMAN
NC score	0.058200 (rank : 421)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	238	Target Neighborhood Hits	821	Shared Neighborhood Hits	35
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

KCC2G_MOUSE
NC score	0.058111 (rank : 422)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	35
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_HUMAN
NC score	0.058111 (rank : 423)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	238	Target Neighborhood Hits	841	Shared Neighborhood Hits	35
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

ULK3_HUMAN
NC score	0.058106 (rank : 424)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

SN1L2_HUMAN
NC score	0.058103 (rank : 425)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	238	Target Neighborhood Hits	964	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

KCC2D_HUMAN
NC score	0.058062 (rank : 426)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

PDK1L_MOUSE
NC score	0.058050 (rank : 427)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	238	Target Neighborhood Hits	821	Shared Neighborhood Hits	35
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

DAPK2_HUMAN
NC score	0.057967 (rank : 428)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	238	Target Neighborhood Hits	832	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

PPE2_MOUSE
NC score	0.057917 (rank : 429)	θ value	0.365318 (rank : 143)
Query Neighborhood Hits	238	Target Neighborhood Hits	112	Shared Neighborhood Hits	65
SwissProt Accessions	O35385	Gene names	Ppef2
Domain Architecture
Description	Serine/threonine-protein phosphatase with EF-hands 2 (EC 3.1.3.16) (PPEF-2).

PIM1_HUMAN
NC score	0.057890 (rank : 430)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	238	Target Neighborhood Hits	797	Shared Neighborhood Hits	35
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PINK1_HUMAN
NC score	0.057860 (rank : 431)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	238	Target Neighborhood Hits	741	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

STK36_HUMAN
NC score	0.057799 (rank : 432)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	238	Target Neighborhood Hits	896	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

KCC2A_MOUSE
NC score	0.057746 (rank : 433)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	238	Target Neighborhood Hits	829	Shared Neighborhood Hits	35
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

SNRK_MOUSE
NC score	0.057655 (rank : 434)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SN1L1_MOUSE
NC score	0.057613 (rank : 435)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	238	Target Neighborhood Hits	895	Shared Neighborhood Hits	36
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

KCC2A_HUMAN
NC score	0.057599 (rank : 436)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
NC score	0.057513 (rank : 437)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	238	Target Neighborhood Hits	866	Shared Neighborhood Hits	35
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

STK36_MOUSE
NC score	0.057496 (rank : 438)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	238	Target Neighborhood Hits	877	Shared Neighborhood Hits	35
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ULK2_MOUSE
NC score	0.057432 (rank : 439)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	238	Target Neighborhood Hits	943	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

MLRA_HUMAN
NC score	0.057335 (rank : 440)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	238	Target Neighborhood Hits	91	Shared Neighborhood Hits	47
SwissProt Accessions	Q01449	Gene names	MYL7, MYLC2A
Domain Architecture
Description	Myosin regulatory light chain 2, atrial isoform (Myosin light chain 2a) (MLC-2a) (MLC2a) (Myosin regulatory light chain 7).

KCC2B_MOUSE
NC score	0.057301 (rank : 441)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	238	Target Neighborhood Hits	841	Shared Neighborhood Hits	35
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

DAPK3_HUMAN
NC score	0.057288 (rank : 442)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	238	Target Neighborhood Hits	945	Shared Neighborhood Hits	35
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DCAK1_MOUSE
NC score	0.057267 (rank : 443)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK1_HUMAN
NC score	0.057233 (rank : 444)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	238	Target Neighborhood Hits	877	Shared Neighborhood Hits	35
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DAPK3_MOUSE
NC score	0.056884 (rank : 445)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	35
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

ULK2_HUMAN
NC score	0.056812 (rank : 446)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	238	Target Neighborhood Hits	979	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK1_HUMAN
NC score	0.056503 (rank : 447)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	238	Target Neighborhood Hits	1121	Shared Neighborhood Hits	36
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

TSSK3_MOUSE
NC score	0.056457 (rank : 448)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	238	Target Neighborhood Hits	806	Shared Neighborhood Hits	35
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

MYL6B_MOUSE
NC score	0.056367 (rank : 449)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	238	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CI43	Gene names	Myl6b
Domain Architecture	No domain graphic available
Description	Myosin light polypeptide 6B (Smooth muscle and nonmuscle myosin light chain alkali 6B).

NEK4_HUMAN
NC score	0.056365 (rank : 450)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	238	Target Neighborhood Hits	883	Shared Neighborhood Hits	35
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

ULK1_MOUSE
NC score	0.056359 (rank : 451)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	238	Target Neighborhood Hits	1214	Shared Neighborhood Hits	38
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

NEK4_MOUSE
NC score	0.056204 (rank : 452)	θ value	θ > 10 (rank : 465)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

PAK4_MOUSE
NC score	0.056182 (rank : 453)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	238	Target Neighborhood Hits	1098	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

MLRV_HUMAN
NC score	0.056168 (rank : 454)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	238	Target Neighborhood Hits	89	Shared Neighborhood Hits	50
SwissProt Accessions	P10916, Q16123	Gene names	MYL2
Domain Architecture
Description	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v).

PAK4_HUMAN
NC score	0.056091 (rank : 455)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	238	Target Neighborhood Hits	924	Shared Neighborhood Hits	35
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

MP2K7_HUMAN
NC score	0.056065 (rank : 456)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	238	Target Neighborhood Hits	833	Shared Neighborhood Hits	35
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

TBK1_MOUSE
NC score	0.056029 (rank : 457)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	238	Target Neighborhood Hits	893	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

TSSK3_HUMAN
NC score	0.055980 (rank : 458)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	238	Target Neighborhood Hits	806	Shared Neighborhood Hits	35
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

MLRV_MOUSE
NC score	0.055909 (rank : 459)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	238	Target Neighborhood Hits	89	Shared Neighborhood Hits	49
SwissProt Accessions	P51667	Gene names	Myl2, Mylpc
Domain Architecture
Description	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v).

PXK_HUMAN
NC score	0.055858 (rank : 460)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	238	Target Neighborhood Hits	216	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

MYL6_HUMAN
NC score	0.055820 (rank : 461)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	238	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	P60660, P16475, P24572, P24573, Q12790, Q6IAZ0, Q6IPY5	Gene names	MYL6
Domain Architecture
Description	Myosin light polypeptide 6 (Smooth muscle and nonmuscle myosin light chain alkali 6) (Myosin light chain alkali 3) (Myosin light chain 3) (MLC-3) (LC17).

MYL6_MOUSE
NC score	0.055820 (rank : 462)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	238	Target Neighborhood Hits	68	Shared Neighborhood Hits	32
SwissProt Accessions	Q60605	Gene names	Myl6, Myln
Domain Architecture
Description	Myosin light polypeptide 6 (Smooth muscle and nonmuscle myosin light chain alkali 6) (Myosin light chain alkali 3) (Myosin light chain 3) (MLC-3) (LC17).

TBK1_HUMAN
NC score	0.055719 (rank : 463)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	238	Target Neighborhood Hits	861	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

CSKP_MOUSE
NC score	0.055656 (rank : 464)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	238	Target Neighborhood Hits	1027	Shared Neighborhood Hits	40
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

TRIO_HUMAN
NC score	0.055609 (rank : 465)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	238	Target Neighborhood Hits	1580	Shared Neighborhood Hits	48
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

PAK7_HUMAN
NC score	0.055604 (rank : 466)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	238	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

DYR1A_HUMAN
NC score	0.055594 (rank : 467)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	238	Target Neighborhood Hits	764	Shared Neighborhood Hits	35
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
NC score	0.055586 (rank : 468)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	238	Target Neighborhood Hits	762	Shared Neighborhood Hits	35
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

E2AK2_MOUSE
NC score	0.055571 (rank : 469)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	238	Target Neighborhood Hits	864	Shared Neighborhood Hits	35
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

FSTL5_MOUSE
NC score	0.055435 (rank : 470)	θ value	0.0330416 (rank : 108)
Query Neighborhood Hits	238	Target Neighborhood Hits	355	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

CALU_MOUSE
NC score	0.055381 (rank : 471)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	238	Target Neighborhood Hits	113	Shared Neighborhood Hits	68
SwissProt Accessions	O35887	Gene names	Calu
Domain Architecture
Description	Calumenin precursor (Crocalbin).

PAK7_MOUSE
NC score	0.055182 (rank : 472)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	238	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

CSKP_HUMAN
NC score	0.055128 (rank : 473)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	238	Target Neighborhood Hits	1022	Shared Neighborhood Hits	38
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CHK1_HUMAN
NC score	0.055024 (rank : 474)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	35
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

M4K3_HUMAN
NC score	0.054968 (rank : 475)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	238	Target Neighborhood Hits	857	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

NEK2_MOUSE
NC score	0.054947 (rank : 476)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	238	Target Neighborhood Hits	876	Shared Neighborhood Hits	35
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

IKKA_HUMAN
NC score	0.054945 (rank : 477)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	238	Target Neighborhood Hits	863	Shared Neighborhood Hits	35
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

IKKA_MOUSE
NC score	0.054925 (rank : 478)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	35
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KSR1_MOUSE
NC score	0.054912 (rank : 479)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	238	Target Neighborhood Hits	870	Shared Neighborhood Hits	49
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MP2K2_HUMAN
NC score	0.054662 (rank : 480)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	238	Target Neighborhood Hits	830	Shared Neighborhood Hits	35
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

CHK1_MOUSE
NC score	0.054650 (rank : 481)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	238	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

NEK1_HUMAN
NC score	0.054626 (rank : 482)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	238	Target Neighborhood Hits	1129	Shared Neighborhood Hits	37
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

M3K6_HUMAN
NC score	0.054609 (rank : 483)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	238	Target Neighborhood Hits	889	Shared Neighborhood Hits	35
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

NEK9_MOUSE
NC score	0.054524 (rank : 484)	θ value	θ > 10 (rank : 469)
Query Neighborhood Hits	238	Target Neighborhood Hits	890	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

MP2K1_HUMAN
NC score	0.054515 (rank : 485)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	238	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
NC score	0.054511 (rank : 486)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	238	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

IKKB_HUMAN
NC score	0.054448 (rank : 487)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	238	Target Neighborhood Hits	980	Shared Neighborhood Hits	37
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MP2K2_MOUSE
NC score	0.054379 (rank : 488)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	35
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

IKKB_MOUSE
NC score	0.054360 (rank : 489)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	238	Target Neighborhood Hits	984	Shared Neighborhood Hits	35
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

M4K2_HUMAN
NC score	0.054356 (rank : 490)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	238	Target Neighborhood Hits	850	Shared Neighborhood Hits	35
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

PAK6_HUMAN
NC score	0.054311 (rank : 491)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	238	Target Neighborhood Hits	915	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

NEK11_HUMAN
NC score	0.054238 (rank : 492)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	238	Target Neighborhood Hits	1043	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

M4K2_MOUSE
NC score	0.054219 (rank : 493)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	238	Target Neighborhood Hits	843	Shared Neighborhood Hits	36
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

DYR1B_HUMAN
NC score	0.054216 (rank : 494)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	238	Target Neighborhood Hits	831	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

NEK11_MOUSE
NC score	0.054201 (rank : 495)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	238	Target Neighborhood Hits	875	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

CALU_HUMAN
NC score	0.054199 (rank : 496)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	238	Target Neighborhood Hits	114	Shared Neighborhood Hits	64
SwissProt Accessions	O43852, O60456, Q6FHB9, Q96RL3, Q9NR43	Gene names	CALU
Domain Architecture
Description	Calumenin precursor (Crocalbin) (IEF SSP 9302).

TTK_MOUSE
NC score	0.054147 (rank : 497)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	238	Target Neighborhood Hits	803	Shared Neighborhood Hits	35
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

NEK1_MOUSE
NC score	0.054020 (rank : 498)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	238	Target Neighborhood Hits	1311	Shared Neighborhood Hits	35
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK9_HUMAN
NC score	0.053949 (rank : 499)	θ value	θ > 10 (rank : 468)
Query Neighborhood Hits	238	Target Neighborhood Hits	900	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

MP2K5_MOUSE
NC score	0.053934 (rank : 500)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	238	Target Neighborhood Hits	840	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

PAK2_HUMAN
NC score	0.053870 (rank : 501)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	238	Target Neighborhood Hits	862	Shared Neighborhood Hits	35
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

DAPK1_MOUSE
NC score	0.053833 (rank : 502)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	238	Target Neighborhood Hits	1138	Shared Neighborhood Hits	39
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ARHG2_HUMAN
NC score	0.053823 (rank : 503)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	238	Target Neighborhood Hits	142	Shared Neighborhood Hits	32
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

DUET_HUMAN
NC score	0.053762 (rank : 504)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	238	Target Neighborhood Hits	1220	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

PAK2_MOUSE
NC score	0.053759 (rank : 505)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

STK35_HUMAN
NC score	0.053733 (rank : 506)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	238	Target Neighborhood Hits	825	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

PAK3_MOUSE
NC score	0.053718 (rank : 507)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	36
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

TTK_HUMAN
NC score	0.053676 (rank : 508)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	238	Target Neighborhood Hits	816	Shared Neighborhood Hits	35
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

PAK1_MOUSE
NC score	0.053655 (rank : 509)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	238	Target Neighborhood Hits	878	Shared Neighborhood Hits	35
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

MYLK_MOUSE
NC score	0.053592 (rank : 510)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	238	Target Neighborhood Hits	1489	Shared Neighborhood Hits	41
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

PAK3_HUMAN
NC score	0.053559 (rank : 511)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	238	Target Neighborhood Hits	887	Shared Neighborhood Hits	36
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK1_HUMAN
NC score	0.053535 (rank : 512)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	238	Target Neighborhood Hits	873	Shared Neighborhood Hits	35
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

NEK2_HUMAN
NC score	0.053530 (rank : 513)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	238	Target Neighborhood Hits	908	Shared Neighborhood Hits	35
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

M3K11_HUMAN
NC score	0.053447 (rank : 514)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	238	Target Neighborhood Hits	1136	Shared Neighborhood Hits	42
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

DYR1B_MOUSE
NC score	0.053380 (rank : 515)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	238	Target Neighborhood Hits	799	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

M3K15_HUMAN
NC score	0.053344 (rank : 516)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	238	Target Neighborhood Hits	914	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

RIPK3_MOUSE
NC score	0.053322 (rank : 517)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

M3K5_MOUSE
NC score	0.053117 (rank : 518)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	238	Target Neighborhood Hits	867	Shared Neighborhood Hits	35
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

PXK_MOUSE
NC score	0.053075 (rank : 519)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	238	Target Neighborhood Hits	320	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

M3K5_HUMAN
NC score	0.053050 (rank : 520)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	238	Target Neighborhood Hits	868	Shared Neighborhood Hits	35
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

CDKL5_HUMAN
NC score	0.052867 (rank : 521)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	238	Target Neighborhood Hits	967	Shared Neighborhood Hits	35
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

MYLK_HUMAN
NC score	0.052793 (rank : 522)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	238	Target Neighborhood Hits	1328	Shared Neighborhood Hits	39
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

M3K1_MOUSE
NC score	0.052707 (rank : 523)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	238	Target Neighborhood Hits	952	Shared Neighborhood Hits	37
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

DYRK2_HUMAN
NC score	0.052415 (rank : 524)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	238	Target Neighborhood Hits	799	Shared Neighborhood Hits	35
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

M4K5_MOUSE
NC score	0.052385 (rank : 525)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	238	Target Neighborhood Hits	839	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

M3K3_MOUSE
NC score	0.052284 (rank : 526)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	238	Target Neighborhood Hits	876	Shared Neighborhood Hits	36
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M4K5_HUMAN
NC score	0.052174 (rank : 527)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	238	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

M3K3_HUMAN
NC score	0.052138 (rank : 528)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	238	Target Neighborhood Hits	885	Shared Neighborhood Hits	36
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

WNK3_HUMAN
NC score	0.052118 (rank : 529)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	238	Target Neighborhood Hits	948	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

DAPK1_HUMAN
NC score	0.052111 (rank : 530)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	238	Target Neighborhood Hits	1130	Shared Neighborhood Hits	39
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

MP2K5_HUMAN
NC score	0.052067 (rank : 531)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	238	Target Neighborhood Hits	837	Shared Neighborhood Hits	35
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

SCYL2_MOUSE
NC score	0.052032 (rank : 532)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	238	Target Neighborhood Hits	603	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

MLE1_HUMAN
NC score	0.052004 (rank : 533)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	238	Target Neighborhood Hits	64	Shared Neighborhood Hits	30
SwissProt Accessions	P05976	Gene names	MYL1
Domain Architecture
Description	Myosin light chain 1, skeletal muscle isoform (MLC1F) (A1 catalytic) (Alkali myosin light chain 1).

M3K2_HUMAN
NC score	0.051972 (rank : 534)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	238	Target Neighborhood Hits	849	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

GMIP_MOUSE
NC score	0.051897 (rank : 535)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	238	Target Neighborhood Hits	202	Shared Neighborhood Hits	40
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

MLE3_HUMAN
NC score	0.051850 (rank : 536)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	238	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	P06741	Gene names	MYL1
Domain Architecture
Description	Myosin light chain 3, skeletal muscle isoform (A2 catalytic) (Alkali myosin light chain 3) (MLC3F).

STK25_HUMAN
NC score	0.051810 (rank : 537)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	238	Target Neighborhood Hits	853	Shared Neighborhood Hits	35
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
NC score	0.051782 (rank : 538)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	238	Target Neighborhood Hits	851	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MST4_MOUSE
NC score	0.051781 (rank : 539)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	238	Target Neighborhood Hits	860	Shared Neighborhood Hits	35
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.051755 (rank : 540)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	238	Target Neighborhood Hits	852	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

E2AK2_HUMAN
NC score	0.051742 (rank : 541)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	238	Target Neighborhood Hits	856	Shared Neighborhood Hits	35
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

MP2K3_MOUSE
NC score	0.051714 (rank : 542)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	238	Target Neighborhood Hits	826	Shared Neighborhood Hits	35
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

RIPK3_HUMAN
NC score	0.051692 (rank : 543)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

M4K1_HUMAN
NC score	0.051663 (rank : 544)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	238	Target Neighborhood Hits	884	Shared Neighborhood Hits	35
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

IKKE_HUMAN
NC score	0.051649 (rank : 545)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	238	Target Neighborhood Hits	837	Shared Neighborhood Hits	35
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

WNK1_HUMAN
NC score	0.051624 (rank : 546)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	238	Target Neighborhood Hits	1158	Shared Neighborhood Hits	37
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

E2AK4_MOUSE
NC score	0.051597 (rank : 547)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	238	Target Neighborhood Hits	984	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

MYL3_MOUSE
NC score	0.051594 (rank : 548)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	238	Target Neighborhood Hits	70	Shared Neighborhood Hits	30
SwissProt Accessions	P09542, Q3UIF4, Q9CQZ2	Gene names	Myl3, Mlc1v, Mylc
Domain Architecture
Description	Myosin light polypeptide 3 (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular/slow twitch myosin alkali light chain).

WNK4_MOUSE
NC score	0.051434 (rank : 549)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	238	Target Neighborhood Hits	961	Shared Neighborhood Hits	35
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

PPE1_HUMAN
NC score	0.051325 (rank : 550)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	238	Target Neighborhood Hits	137	Shared Neighborhood Hits	73
SwissProt Accessions	O14829, O15253, Q9NU21, Q9UJH0	Gene names	PPEF1, PPEF, PPP7C
Domain Architecture
Description	Serine/threonine-protein phosphatase with EF-hands 1 (EC 3.1.3.16) (PPEF-1) (Protein phosphatase with EF calcium-binding domain) (PPEF) (Serine/threonine-protein phosphatase 7) (PP7).

STK24_MOUSE
NC score	0.051293 (rank : 551)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	238	Target Neighborhood Hits	856	Shared Neighborhood Hits	35
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

NEK8_HUMAN
NC score	0.051246 (rank : 552)	θ value	θ > 10 (rank : 466)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

WNK1_MOUSE
NC score	0.051245 (rank : 553)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	238	Target Neighborhood Hits	1179	Shared Neighborhood Hits	36
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

RCN3_HUMAN
NC score	0.051238 (rank : 554)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	238	Target Neighborhood Hits	89	Shared Neighborhood Hits	63
SwissProt Accessions	Q96D15, Q9HBZ8	Gene names	RCN3
Domain Architecture
Description	Reticulocalbin-3 precursor (EF-hand calcium-binding protein RLP49).

NEK8_MOUSE
NC score	0.051179 (rank : 555)	θ value	θ > 10 (rank : 467)
Query Neighborhood Hits	238	Target Neighborhood Hits	872	Shared Neighborhood Hits	35
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

STK24_HUMAN
NC score	0.051137 (rank : 556)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	238	Target Neighborhood Hits	853	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

M4K1_MOUSE
NC score	0.051111 (rank : 557)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	238	Target Neighborhood Hits	858	Shared Neighborhood Hits	35
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

TLK1_MOUSE
NC score	0.051069 (rank : 558)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	238	Target Neighborhood Hits	947	Shared Neighborhood Hits	37
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

TLK1_HUMAN
NC score	0.051013 (rank : 559)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	238	Target Neighborhood Hits	967	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

WNK4_HUMAN
NC score	0.050961 (rank : 560)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	238	Target Neighborhood Hits	1043	Shared Neighborhood Hits	35
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

MLE1_MOUSE
NC score	0.050938 (rank : 561)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	238	Target Neighborhood Hits	69	Shared Neighborhood Hits	30
SwissProt Accessions	P05977	Gene names	Myl1, Mylf
Domain Architecture
Description	Myosin light chain 1, skeletal muscle isoform (MLC1F) (A1 catalytic) (Alkali myosin light chain 1).

SCYL2_HUMAN
NC score	0.050935 (rank : 562)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	238	Target Neighborhood Hits	632	Shared Neighborhood Hits	35
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

HIPK2_HUMAN
NC score	0.050905 (rank : 563)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	238	Target Neighborhood Hits	845	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
NC score	0.050878 (rank : 564)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	238	Target Neighborhood Hits	871	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

M3K4_HUMAN
NC score	0.050809 (rank : 565)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	238	Target Neighborhood Hits	911	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

MLE3_MOUSE
NC score	0.050746 (rank : 566)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	238	Target Neighborhood Hits	66	Shared Neighborhood Hits	29
SwissProt Accessions	P05978	Gene names	Myl1, Mylf
Domain Architecture
Description	Myosin light chain 3, skeletal muscle isoform (A2 catalytic) (Alkali myosin light chain 3) (MLC3F).

RCN3_MOUSE
NC score	0.050601 (rank : 567)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	238	Target Neighborhood Hits	91	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BH97, Q58E50, Q8R137, Q99K35, Q9CTD4	Gene names	Rcn3, D7Ertd671e
Domain Architecture	No domain graphic available
Description	Reticulocalbin-3 precursor.

M3K2_MOUSE
NC score	0.050580 (rank : 568)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	238	Target Neighborhood Hits	846	Shared Neighborhood Hits	35
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

MYO3B_HUMAN
NC score	0.050548 (rank : 569)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	238	Target Neighborhood Hits	923	Shared Neighborhood Hits	37
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

M3K4_MOUSE
NC score	0.050521 (rank : 570)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	238	Target Neighborhood Hits	924	Shared Neighborhood Hits	35
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

OXSR1_MOUSE
NC score	0.050507 (rank : 571)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	238	Target Neighborhood Hits	865	Shared Neighborhood Hits	36
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ARHG2_MOUSE
NC score	0.050497 (rank : 572)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	238	Target Neighborhood Hits	120	Shared Neighborhood Hits	31
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

TLK2_HUMAN
NC score	0.050490 (rank : 573)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	238	Target Neighborhood Hits	1044	Shared Neighborhood Hits	36
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

MLTK_HUMAN
NC score	0.050473 (rank : 574)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	238	Target Neighborhood Hits	911	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

STK39_HUMAN
NC score	0.050471 (rank : 575)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	238	Target Neighborhood Hits	882	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

RIPK2_MOUSE
NC score	0.050468 (rank : 576)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	238	Target Neighborhood Hits	776	Shared Neighborhood Hits	35
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

NRK_MOUSE
NC score	0.050453 (rank : 577)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	238	Target Neighborhood Hits	899	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

MLTK_MOUSE
NC score	0.050449 (rank : 578)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

STK39_MOUSE
NC score	0.050403 (rank : 579)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	238	Target Neighborhood Hits	915	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

E2AK4_HUMAN
NC score	0.050333 (rank : 580)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	238	Target Neighborhood Hits	1012	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

SPEG_HUMAN
NC score	0.050301 (rank : 581)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	238	Target Neighborhood Hits	1762	Shared Neighborhood Hits	41
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

IRAK1_MOUSE
NC score	0.050167 (rank : 582)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	238	Target Neighborhood Hits	784	Shared Neighborhood Hits	36
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

OXSR1_HUMAN
NC score	0.050163 (rank : 583)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	238	Target Neighborhood Hits	874	Shared Neighborhood Hits	35
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

TLK2_MOUSE
NC score	0.050108 (rank : 584)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	238	Target Neighborhood Hits	1088	Shared Neighborhood Hits	36
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

SPTA2_HUMAN
NC score	0.047011 (rank : 585)	θ value	1.81305 (rank : 182)
Query Neighborhood Hits	238	Target Neighborhood Hits	888	Shared Neighborhood Hits	92
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

2ACC_HUMAN
NC score	0.045437 (rank : 586)	θ value	0.21417 (rank : 135)
Query Neighborhood Hits	238	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y5P8	Gene names	PPP2R3B, PPP2R3L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein phosphatase 2A 48 kDa regulatory subunit B (PP2A, subunit B, PR48 isoform).

DJBP_HUMAN
NC score	0.041604 (rank : 587)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	238	Target Neighborhood Hits	156	Shared Neighborhood Hits	50
SwissProt Accessions	Q5THR3, Q5U5T6, Q9BY88, Q9H5C4, Q9NSF5	Gene names	DJBP, KIAA1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein (CAP-binding protein complex-interacting protein 1).

SPHK2_HUMAN
NC score	0.041369 (rank : 588)	θ value	8.99809 (rank : 236)
Query Neighborhood Hits	238	Target Neighborhood Hits	81	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NRA0, Q9BRN1, Q9H0Q2, Q9NWU7	Gene names	SPHK2
Domain Architecture
Description	Sphingosine kinase 2 (EC 2.7.1.-) (SK 2) (SPK 2).

FSTL5_HUMAN
NC score	0.036164 (rank : 589)	θ value	0.62314 (rank : 153)
Query Neighborhood Hits	238	Target Neighborhood Hits	347	Shared Neighborhood Hits	39
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

SNCAP_HUMAN
NC score	0.030044 (rank : 590)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	238	Target Neighborhood Hits	313	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

FSTL4_HUMAN
NC score	0.028084 (rank : 591)	θ value	0.279714 (rank : 140)
Query Neighborhood Hits	238	Target Neighborhood Hits	344	Shared Neighborhood Hits	18
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FSTL4_MOUSE
NC score	0.021548 (rank : 592)	θ value	4.03905 (rank : 199)
Query Neighborhood Hits	238	Target Neighborhood Hits	333	Shared Neighborhood Hits	13
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

NTNG2_MOUSE
NC score	0.019859 (rank : 593)	θ value	0.163984 (rank : 133)
Query Neighborhood Hits	238	Target Neighborhood Hits	276	Shared Neighborhood Hits	13
SwissProt Accessions	Q8R4F1, Q8R4F2, Q8VIP6, Q8VIP7, Q8VIP8	Gene names	Ntng2, Lmnt2
Domain Architecture
Description	Netrin G2 precursor (Laminet-2).

KNG1_HUMAN
NC score	0.015804 (rank : 594)	θ value	1.38821 (rank : 170)
Query Neighborhood Hits	238	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	P01042, P01043	Gene names	KNG1, BDK, KNG
Domain Architecture
Description	Kininogen-1 precursor (Alpha-2-thiol proteinase inhibitor) [Contains: Kininogen-1 heavy chain; Bradykinin (Kallidin I); Lysyl-bradykinin (Kallidin II); Kininogen-1 light chain; Low molecular weight growth- promoting factor].

NTNG2_HUMAN
NC score	0.014018 (rank : 595)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	238	Target Neighborhood Hits	276	Shared Neighborhood Hits	13
SwissProt Accessions	Q96CW9, Q6UXY0, Q96JH0	Gene names	NTNG2, KIAA1857, LMNT2
Domain Architecture
Description	Netrin G2 precursor (Laminet-2).

ZN592_MOUSE
NC score	0.013757 (rank : 596)	θ value	0.21417 (rank : 138)
Query Neighborhood Hits	238	Target Neighborhood Hits	768	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BHZ4, Q80XM1	Gene names	Znf592, Kiaa0211, Zfp592
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592 (Zfp-592).

BI2L1_MOUSE
NC score	0.013561 (rank : 597)	θ value	1.38821 (rank : 164)
Query Neighborhood Hits	238	Target Neighborhood Hits	197	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

ZN592_HUMAN
NC score	0.012433 (rank : 598)	θ value	1.81305 (rank : 186)
Query Neighborhood Hits	238	Target Neighborhood Hits	762	Shared Neighborhood Hits	27
SwissProt Accessions	Q92610	Gene names	ZNF592, KIAA0211
Domain Architecture	No domain graphic available
Description	Zinc finger protein 592.

LAMC1_HUMAN
NC score	0.011080 (rank : 599)	θ value	0.813845 (rank : 158)
Query Neighborhood Hits	238	Target Neighborhood Hits	922	Shared Neighborhood Hits	18
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

GP2_HUMAN
NC score	0.011051 (rank : 600)	θ value	1.38821 (rank : 168)
Query Neighborhood Hits	238	Target Neighborhood Hits	34	Shared Neighborhood Hits	2
SwissProt Accessions	P55259, Q13338, Q9UIF1	Gene names	GP2
Domain Architecture
Description	Pancreatic secretory granule membrane major glycoprotein GP2 precursor (Pancreatic zymogen granule membrane protein GP-2) (ZAP75).

MEGF9_HUMAN
NC score	0.010724 (rank : 601)	θ value	0.813845 (rank : 159)
Query Neighborhood Hits	238	Target Neighborhood Hits	557	Shared Neighborhood Hits	13
SwissProt Accessions	Q9H1U4, O75098	Gene names	MEGF9, EGFL5, KIAA0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

LAMC1_MOUSE
NC score	0.009907 (rank : 602)	θ value	8.99809 (rank : 232)
Query Neighborhood Hits	238	Target Neighborhood Hits	856	Shared Neighborhood Hits	17
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

TCF17_HUMAN
NC score	0.008470 (rank : 603)	θ value	0.813845 (rank : 160)
Query Neighborhood Hits	238	Target Neighborhood Hits	797	Shared Neighborhood Hits	38
SwissProt Accessions	O60765, Q9UNJ8	Gene names	ZNF354A, EZNF, HKL1, TCF17
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Zinc finger protein eZNF).

LAMA1_MOUSE
NC score	0.008376 (rank : 604)	θ value	1.81305 (rank : 180)
Query Neighborhood Hits	238	Target Neighborhood Hits	838	Shared Neighborhood Hits	21
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

FRAS1_MOUSE
NC score	0.008359 (rank : 605)	θ value	1.38821 (rank : 167)
Query Neighborhood Hits	238	Target Neighborhood Hits	747	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

ZN197_HUMAN
NC score	0.008190 (rank : 606)	θ value	4.03905 (rank : 204)
Query Neighborhood Hits	238	Target Neighborhood Hits	788	Shared Neighborhood Hits	33
SwissProt Accessions	O14709	Gene names	ZNF197, ZNF166
Domain Architecture
Description	Zinc finger protein 197 (ZnF20).

CERK1_MOUSE
NC score	0.007695 (rank : 607)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	238	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4Q7	Gene names	Cerk
Domain Architecture
Description	Ceramide kinase (EC 2.7.1.138) (Acylsphingosine kinase) (mCERK).

ZN347_HUMAN
NC score	0.007363 (rank : 608)	θ value	1.38821 (rank : 173)
Query Neighborhood Hits	238	Target Neighborhood Hits	756	Shared Neighborhood Hits	28
SwissProt Accessions	Q96SE7, Q8TCN1	Gene names	ZNF347, ZNF1111
Domain Architecture
Description	Zinc finger protein 347 (Zinc finger protein 1111).

ZN271_HUMAN
NC score	0.007352 (rank : 609)	θ value	1.81305 (rank : 185)
Query Neighborhood Hits	238	Target Neighborhood Hits	769	Shared Neighborhood Hits	36
SwissProt Accessions	Q14591, Q96T29, Q9BSX2, Q9UN33, Q9Y5B7	Gene names	ZNF271, ZNFEB
Domain Architecture	No domain graphic available
Description	Zinc finger protein 271 (Zinc finger protein HZF7) (Zinc finger protein ZNFphex133) (Epstein-Barr virus-induced zinc finger protein) (ZNF-EB) (CT-ZFP48) (Zinc finger protein dp) (ZNF-dp).

ZN334_HUMAN
NC score	0.007287 (rank : 610)	θ value	4.03905 (rank : 205)
Query Neighborhood Hits	238	Target Neighborhood Hits	778	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCZ1, Q5T6U2, Q9NVW4	Gene names	ZNF334
Domain Architecture
Description	Zinc finger protein 334.

TCF17_MOUSE
NC score	0.007284 (rank : 611)	θ value	2.36792 (rank : 189)
Query Neighborhood Hits	238	Target Neighborhood Hits	786	Shared Neighborhood Hits	34
SwissProt Accessions	Q61751	Gene names	Znf354a, Kid1, Tcf17, Zfp354a
Domain Architecture
Description	Zinc finger protein 354A (Transcription factor 17) (Renal transcription factor Kid-1) (Kidney, ischemia, and developmentally- regulated protein 1).

TRI47_MOUSE
NC score	0.007159 (rank : 612)	θ value	1.81305 (rank : 184)
Query Neighborhood Hits	238	Target Neighborhood Hits	295	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

ZN624_HUMAN
NC score	0.007157 (rank : 613)	θ value	1.06291 (rank : 163)
Query Neighborhood Hits	238	Target Neighborhood Hits	775	Shared Neighborhood Hits	31
SwissProt Accessions	Q9P2J8	Gene names	ZNF624, KIAA1349
Domain Architecture	No domain graphic available
Description	Zinc finger protein 624.

ZN546_HUMAN
NC score	0.007148 (rank : 614)	θ value	4.03905 (rank : 206)
Query Neighborhood Hits	238	Target Neighborhood Hits	772	Shared Neighborhood Hits	33
SwissProt Accessions	Q86UE3	Gene names	ZNF546, ZNF49
Domain Architecture	No domain graphic available
Description	Zinc finger protein 546.

ZN600_HUMAN
NC score	0.007072 (rank : 615)	θ value	8.99809 (rank : 238)
Query Neighborhood Hits	238	Target Neighborhood Hits	774	Shared Neighborhood Hits	35
SwissProt Accessions	Q6ZNG1, Q6MZR0	Gene names	ZNF600
Domain Architecture	No domain graphic available
Description	Zinc finger protein 600.

ZN611_HUMAN
NC score	0.006749 (rank : 616)	θ value	0.47712 (rank : 149)
Query Neighborhood Hits	238	Target Neighborhood Hits	769	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N823, Q69YG9	Gene names	ZNF611
Domain Architecture	No domain graphic available
Description	Zinc finger protein 611.

ZN700_HUMAN
NC score	0.006342 (rank : 617)	θ value	0.47712 (rank : 150)
Query Neighborhood Hits	238	Target Neighborhood Hits	772	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H0M5	Gene names	ZNF700
Domain Architecture	No domain graphic available
Description	Zinc finger protein 700.

LAMA5_MOUSE
NC score	0.006264 (rank : 618)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	238	Target Neighborhood Hits	828	Shared Neighborhood Hits	19
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

ZN506_HUMAN
NC score	0.006198 (rank : 619)	θ value	5.27518 (rank : 216)
Query Neighborhood Hits	238	Target Neighborhood Hits	743	Shared Neighborhood Hits	32
SwissProt Accessions	Q5JVG8	Gene names	ZNF506
Domain Architecture	No domain graphic available
Description	Zinc finger protein 506.

ZNF73_HUMAN
NC score	0.006177 (rank : 620)	θ value	0.47712 (rank : 151)
Query Neighborhood Hits	238	Target Neighborhood Hits	716	Shared Neighborhood Hits	28
SwissProt Accessions	O43830, Q9UC08	Gene names	ZNF73, ZNF186
Domain Architecture	No domain graphic available
Description	Zinc finger protein 73 (Zinc finger protein 186) (hZNF2).

ZN682_HUMAN
NC score	0.006168 (rank : 621)	θ value	3.0926 (rank : 195)
Query Neighborhood Hits	238	Target Neighborhood Hits	779	Shared Neighborhood Hits	39
SwissProt Accessions	O95780, Q96JV9	Gene names	ZNF682
Domain Architecture	No domain graphic available
Description	Zinc finger protein 682.

ZNF74_HUMAN
NC score	0.005983 (rank : 622)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	238	Target Neighborhood Hits	770	Shared Neighborhood Hits	35
SwissProt Accessions	Q16587, Q6IBV2, Q9UC04, Q9UF05, Q9UF06, Q9UF07	Gene names	ZNF74
Domain Architecture
Description	Zinc finger protein 74 (hZNF7).

ZN542_HUMAN
NC score	0.005931 (rank : 623)	θ value	3.0926 (rank : 194)
Query Neighborhood Hits	238	Target Neighborhood Hits	735	Shared Neighborhood Hits	33
SwissProt Accessions	Q5EBM4, Q6N061	Gene names	ZNF542
Domain Architecture	No domain graphic available
Description	Zinc finger protein 542.

ZN271_MOUSE
NC score	0.005848 (rank : 624)	θ value	1.38821 (rank : 172)
Query Neighborhood Hits	238	Target Neighborhood Hits	746	Shared Neighborhood Hits	33
SwissProt Accessions	P15620	Gene names	Znf271, Zfp-35, Zfp35
Domain Architecture	No domain graphic available
Description	Zinc finger protein 271 (Zinc finger protein 35) (Zfp-35).

KLD8B_MOUSE
NC score	0.005618 (rank : 625)	θ value	2.36792 (rank : 188)
Query Neighborhood Hits	238	Target Neighborhood Hits	80	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D2D9	Gene names	Klhdc8b
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 8B.

PCSK5_MOUSE
NC score	0.005485 (rank : 626)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	238	Target Neighborhood Hits	613	Shared Neighborhood Hits	20
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

STAB2_HUMAN
NC score	0.005122 (rank : 627)	θ value	1.81305 (rank : 183)
Query Neighborhood Hits	238	Target Neighborhood Hits	534	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WWQ8, Q6ZMK2, Q7Z5N9, Q86UR4, Q8IUG9, Q8TES1, Q9H7H7, Q9NRY3	Gene names	STAB2, FEEL2, FELL, FEX2, HARE
Domain Architecture	No domain graphic available
Description	Stabilin-2 precursor (FEEL-2 protein) (Fasciclin EGF-like laminin-type EGF-like and link domain-containing scavenger receptor 1) (FAS1 EGF- like and X-link domain-containing adhesion molecule 2) (Hyaluronan receptor for endocytosis) [Contains: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)].

TRI47_HUMAN
NC score	0.005017 (rank : 628)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	238	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

ZFP37_MOUSE
NC score	0.004792 (rank : 629)	θ value	0.62314 (rank : 157)
Query Neighborhood Hits	238	Target Neighborhood Hits	906	Shared Neighborhood Hits	27
SwissProt Accessions	P17141, Q62514	Gene names	Zfp37, Zfp-37
Domain Architecture
Description	Zinc finger protein 37 (Zfp-37) (Male germ cell-specific zinc finger protein).

ZN192_HUMAN
NC score	0.004651 (rank : 630)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	238	Target Neighborhood Hits	789	Shared Neighborhood Hits	32
SwissProt Accessions	Q15776, Q4VAR1, Q4VAR2, Q4VAR3, Q9H4T1	Gene names	ZNF192
Domain Architecture
Description	Zinc finger protein 192 (LD5-1).

ZN181_HUMAN
NC score	0.004293 (rank : 631)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	238	Target Neighborhood Hits	764	Shared Neighborhood Hits	27
SwissProt Accessions	Q2M3W8, Q49A75	Gene names	ZNF181
Domain Architecture	No domain graphic available
Description	Zinc finger protein 181 (HHZ181).

ZN248_HUMAN
NC score	0.003797 (rank : 632)	θ value	3.0926 (rank : 193)
Query Neighborhood Hits	238	Target Neighborhood Hits	749	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NDW4, Q9UMP3	Gene names	ZNF248
Domain Architecture
Description	Zinc finger protein 248.

ZN282_HUMAN
NC score	0.002630 (rank : 633)	θ value	8.99809 (rank : 237)
Query Neighborhood Hits	238	Target Neighborhood Hits	796	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UDV7, O43691, Q6DKK0	Gene names	ZNF282, HUB1
Domain Architecture
Description	Zinc finger protein 282 (HTLV-I U5RE-binding protein 1) (HUB-1).

FCN1_MOUSE
NC score	0.001996 (rank : 634)	θ value	2.36792 (rank : 187)
Query Neighborhood Hits	238	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	O70165	Gene names	Fcn1, Fcna
Domain Architecture
Description	Ficolin-1 precursor (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin A) (M-Ficolin).

MAGI2_HUMAN
NC score	0.000524 (rank : 635)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	238	Target Neighborhood Hits	373	Shared Neighborhood Hits	4
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).