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Network neighborhood for query Sequence : NEK1_MOUSE

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NEK1_MOUSE
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NEK1_HUMAN
θ value	0 (rank : 1)	NC score	0.993698 (rank : 2)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1129	Shared Neighborhood Hits	980
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1311	Shared Neighborhood Hits	1311
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK3_HUMAN
θ value	1.88829e-90 (rank : 3)	NC score	0.985557 (rank : 3)
Query Neighborhood Hits	1311	Target Neighborhood Hits	865	Shared Neighborhood Hits	849
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
θ value	8.20983e-86 (rank : 4)	NC score	0.985309 (rank : 4)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	841
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_MOUSE
θ value	5.69867e-79 (rank : 5)	NC score	0.983529 (rank : 5)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	848
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK4_HUMAN
θ value	9.7205e-79 (rank : 6)	NC score	0.982388 (rank : 6)
Query Neighborhood Hits	1311	Target Neighborhood Hits	883	Shared Neighborhood Hits	842
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK8_HUMAN
θ value	7.98882e-65 (rank : 7)	NC score	0.966226 (rank : 17)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	841
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	1.36269e-64 (rank : 8)	NC score	0.965993 (rank : 18)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	840
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK9_HUMAN
θ value	1.41016e-61 (rank : 9)	NC score	0.960770 (rank : 53)
Query Neighborhood Hits	1311	Target Neighborhood Hits	900	Shared Neighborhood Hits	844
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

NEK9_MOUSE
θ value	1.19377e-60 (rank : 10)	NC score	0.960299 (rank : 55)
Query Neighborhood Hits	1311	Target Neighborhood Hits	890	Shared Neighborhood Hits	845
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

NEK11_HUMAN
θ value	5.54529e-58 (rank : 11)	NC score	0.976967 (rank : 9)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1043	Shared Neighborhood Hits	911
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK11_MOUSE
θ value	8.00737e-57 (rank : 12)	NC score	0.976482 (rank : 12)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	843
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK2_HUMAN
θ value	2.041e-52 (rank : 13)	NC score	0.978381 (rank : 7)
Query Neighborhood Hits	1311	Target Neighborhood Hits	908	Shared Neighborhood Hits	845
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
θ value	5.93839e-52 (rank : 14)	NC score	0.977066 (rank : 8)
Query Neighborhood Hits	1311	Target Neighborhood Hits	876	Shared Neighborhood Hits	833
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK6_HUMAN
θ value	1.97686e-47 (rank : 15)	NC score	0.976949 (rank : 10)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	842
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK7_HUMAN
θ value	1.97686e-47 (rank : 16)	NC score	0.976358 (rank : 14)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	841
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK6_MOUSE
θ value	1.28137e-46 (rank : 17)	NC score	0.976842 (rank : 11)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	842
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK7_MOUSE
θ value	1.28137e-46 (rank : 18)	NC score	0.976394 (rank : 13)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	842
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

STK36_HUMAN
θ value	3.99248e-40 (rank : 19)	NC score	0.971939 (rank : 15)
Query Neighborhood Hits	1311	Target Neighborhood Hits	896	Shared Neighborhood Hits	848
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
θ value	1.57e-36 (rank : 20)	NC score	0.970843 (rank : 16)
Query Neighborhood Hits	1311	Target Neighborhood Hits	877	Shared Neighborhood Hits	847
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

KS6A1_HUMAN
θ value	8.61488e-35 (rank : 21)	NC score	0.944479 (rank : 167)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	843
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
θ value	8.61488e-35 (rank : 22)	NC score	0.944308 (rank : 168)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	842
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

KS6A2_MOUSE
θ value	8.61488e-35 (rank : 23)	NC score	0.944714 (rank : 163)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	844
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

PLK4_MOUSE
θ value	8.61488e-35 (rank : 24)	NC score	0.965964 (rank : 19)
Query Neighborhood Hits	1311	Target Neighborhood Hits	879	Shared Neighborhood Hits	841
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

KS6A3_HUMAN
θ value	1.12514e-34 (rank : 25)	NC score	0.943180 (rank : 176)
Query Neighborhood Hits	1311	Target Neighborhood Hits	859	Shared Neighborhood Hits	844
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	1.12514e-34 (rank : 26)	NC score	0.943167 (rank : 177)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	844
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

PLK2_HUMAN
θ value	3.27365e-34 (rank : 27)	NC score	0.965688 (rank : 20)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	838
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	3.27365e-34 (rank : 28)	NC score	0.965415 (rank : 21)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	837
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK3_HUMAN
θ value	3.27365e-34 (rank : 29)	NC score	0.964287 (rank : 28)
Query Neighborhood Hits	1311	Target Neighborhood Hits	865	Shared Neighborhood Hits	840
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

KS6B2_MOUSE
θ value	5.584e-34 (rank : 30)	NC score	0.936844 (rank : 228)
Query Neighborhood Hits	1311	Target Neighborhood Hits	871	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PLK4_HUMAN
θ value	7.29293e-34 (rank : 31)	NC score	0.964791 (rank : 24)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	843
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

KS6A6_HUMAN
θ value	9.52487e-34 (rank : 32)	NC score	0.942391 (rank : 180)
Query Neighborhood Hits	1311	Target Neighborhood Hits	853	Shared Neighborhood Hits	841
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KAPCA_HUMAN
θ value	1.24399e-33 (rank : 33)	NC score	0.937618 (rank : 222)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	831
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_MOUSE
θ value	1.24399e-33 (rank : 34)	NC score	0.937679 (rank : 221)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	831
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

PLK3_MOUSE
θ value	1.24399e-33 (rank : 35)	NC score	0.963904 (rank : 31)
Query Neighborhood Hits	1311	Target Neighborhood Hits	863	Shared Neighborhood Hits	840
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

KAPCG_HUMAN
θ value	1.6247e-33 (rank : 36)	NC score	0.942862 (rank : 178)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	836
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

KS6B2_HUMAN
θ value	1.6247e-33 (rank : 37)	NC score	0.939598 (rank : 206)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	834
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

MARK3_MOUSE
θ value	4.72714e-33 (rank : 38)	NC score	0.953939 (rank : 99)
Query Neighborhood Hits	1311	Target Neighborhood Hits	919	Shared Neighborhood Hits	844
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MARK1_MOUSE
θ value	6.17384e-33 (rank : 39)	NC score	0.952908 (rank : 101)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	842
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

STK10_HUMAN
θ value	8.06329e-33 (rank : 40)	NC score	0.914881 (rank : 386)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1921	Shared Neighborhood Hits	1079
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

MARK1_HUMAN
θ value	1.0531e-32 (rank : 41)	NC score	0.952905 (rank : 102)
Query Neighborhood Hits	1311	Target Neighborhood Hits	887	Shared Neighborhood Hits	844
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

STK10_MOUSE
θ value	2.34606e-32 (rank : 42)	NC score	0.893945 (rank : 482)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2132	Shared Neighborhood Hits	1114
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

KS6B1_HUMAN
θ value	5.22648e-32 (rank : 43)	NC score	0.941286 (rank : 191)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	833
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	5.22648e-32 (rank : 44)	NC score	0.941306 (rank : 190)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	832
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

MARK4_HUMAN
θ value	5.22648e-32 (rank : 45)	NC score	0.955339 (rank : 92)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	843
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	5.22648e-32 (rank : 46)	NC score	0.955244 (rank : 93)
Query Neighborhood Hits	1311	Target Neighborhood Hits	898	Shared Neighborhood Hits	844
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

STK24_HUMAN
θ value	5.22648e-32 (rank : 47)	NC score	0.958696 (rank : 67)
Query Neighborhood Hits	1311	Target Neighborhood Hits	853	Shared Neighborhood Hits	840
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

ULK1_HUMAN
θ value	5.22648e-32 (rank : 48)	NC score	0.962709 (rank : 40)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1121	Shared Neighborhood Hits	853
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

ULK1_MOUSE
θ value	5.22648e-32 (rank : 49)	NC score	0.960192 (rank : 57)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1214	Shared Neighborhood Hits	861
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

AKT2_HUMAN
θ value	6.82597e-32 (rank : 50)	NC score	0.934603 (rank : 252)
Query Neighborhood Hits	1311	Target Neighborhood Hits	878	Shared Neighborhood Hits	829
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT2_MOUSE
θ value	6.82597e-32 (rank : 51)	NC score	0.934263 (rank : 254)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	829
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AKT3_HUMAN
θ value	8.91499e-32 (rank : 52)	NC score	0.936121 (rank : 235)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	8.91499e-32 (rank : 53)	NC score	0.936104 (rank : 236)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

STK24_MOUSE
θ value	8.91499e-32 (rank : 54)	NC score	0.958014 (rank : 76)
Query Neighborhood Hits	1311	Target Neighborhood Hits	856	Shared Neighborhood Hits	842
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

M3K4_HUMAN
θ value	1.16434e-31 (rank : 55)	NC score	0.963583 (rank : 34)
Query Neighborhood Hits	1311	Target Neighborhood Hits	911	Shared Neighborhood Hits	848
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

M3K4_MOUSE
θ value	1.16434e-31 (rank : 56)	NC score	0.962910 (rank : 37)
Query Neighborhood Hits	1311	Target Neighborhood Hits	924	Shared Neighborhood Hits	848
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

MARK2_HUMAN
θ value	1.16434e-31 (rank : 57)	NC score	0.952340 (rank : 108)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1056	Shared Neighborhood Hits	866
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

SLK_HUMAN
θ value	1.52067e-31 (rank : 58)	NC score	0.931386 (rank : 272)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1775	Shared Neighborhood Hits	1062
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

AKT1_HUMAN
θ value	1.98606e-31 (rank : 59)	NC score	0.930959 (rank : 275)
Query Neighborhood Hits	1311	Target Neighborhood Hits	885	Shared Neighborhood Hits	830
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
θ value	1.98606e-31 (rank : 60)	NC score	0.930881 (rank : 276)
Query Neighborhood Hits	1311	Target Neighborhood Hits	878	Shared Neighborhood Hits	830
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

KS6A1_MOUSE
θ value	2.59387e-31 (rank : 61)	NC score	0.939174 (rank : 208)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	840
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

SLK_MOUSE
θ value	2.59387e-31 (rank : 62)	NC score	0.933035 (rank : 260)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1798	Shared Neighborhood Hits	1076
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

KCC2G_HUMAN
θ value	3.3877e-31 (rank : 63)	NC score	0.942372 (rank : 183)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	824
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	3.3877e-31 (rank : 64)	NC score	0.942385 (rank : 181)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

NIM1_HUMAN
θ value	3.3877e-31 (rank : 65)	NC score	0.957520 (rank : 81)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	835
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

KAPCB_MOUSE
θ value	4.42448e-31 (rank : 66)	NC score	0.935542 (rank : 247)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	830
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

M4K2_HUMAN
θ value	4.42448e-31 (rank : 67)	NC score	0.946238 (rank : 152)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	827
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

SGK3_MOUSE
θ value	4.42448e-31 (rank : 68)	NC score	0.930996 (rank : 274)
Query Neighborhood Hits	1311	Target Neighborhood Hits	882	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

M4K2_MOUSE
θ value	7.54701e-31 (rank : 69)	NC score	0.947029 (rank : 139)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

PLK1_HUMAN
θ value	7.54701e-31 (rank : 70)	NC score	0.964911 (rank : 23)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	834
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KCC2D_HUMAN
θ value	9.8567e-31 (rank : 71)	NC score	0.940148 (rank : 202)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

MARK2_MOUSE
θ value	9.8567e-31 (rank : 72)	NC score	0.951200 (rank : 114)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1018	Shared Neighborhood Hits	860
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MST4_HUMAN
θ value	9.8567e-31 (rank : 73)	NC score	0.956911 (rank : 84)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	839
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
θ value	9.8567e-31 (rank : 74)	NC score	0.956884 (rank : 85)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	840
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

KAPCB_HUMAN
θ value	1.28732e-30 (rank : 75)	NC score	0.935778 (rank : 240)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	830
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KCC2A_HUMAN
θ value	1.28732e-30 (rank : 76)	NC score	0.940658 (rank : 197)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	821
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

PAK3_HUMAN
θ value	1.28732e-30 (rank : 77)	NC score	0.959603 (rank : 62)
Query Neighborhood Hits	1311	Target Neighborhood Hits	887	Shared Neighborhood Hits	843
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	1.28732e-30 (rank : 78)	NC score	0.959761 (rank : 60)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	842
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

SGK3_HUMAN
θ value	1.28732e-30 (rank : 79)	NC score	0.930537 (rank : 279)
Query Neighborhood Hits	1311	Target Neighborhood Hits	877	Shared Neighborhood Hits	827
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

NIM1_MOUSE
θ value	1.6813e-30 (rank : 80)	NC score	0.957600 (rank : 79)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	839
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

MARK3_HUMAN
θ value	2.86786e-30 (rank : 81)	NC score	0.948300 (rank : 127)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	834
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

NUAK2_HUMAN
θ value	2.86786e-30 (rank : 82)	NC score	0.960967 (rank : 52)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	841
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NUAK1_HUMAN
θ value	3.74554e-30 (rank : 83)	NC score	0.959604 (rank : 61)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	839
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

PAK1_HUMAN
θ value	3.74554e-30 (rank : 84)	NC score	0.959855 (rank : 58)
Query Neighborhood Hits	1311	Target Neighborhood Hits	873	Shared Neighborhood Hits	839
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

STK25_MOUSE
θ value	3.74554e-30 (rank : 85)	NC score	0.955826 (rank : 87)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	838
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

NUAK1_MOUSE
θ value	4.89182e-30 (rank : 86)	NC score	0.958948 (rank : 64)
Query Neighborhood Hits	1311	Target Neighborhood Hits	881	Shared Neighborhood Hits	844
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

M4K3_HUMAN
θ value	6.38894e-30 (rank : 87)	NC score	0.949069 (rank : 124)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

STK3_HUMAN
θ value	6.38894e-30 (rank : 88)	NC score	0.958665 (rank : 68)
Query Neighborhood Hits	1311	Target Neighborhood Hits	861	Shared Neighborhood Hits	839
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

PAK2_MOUSE
θ value	8.3442e-30 (rank : 89)	NC score	0.961816 (rank : 47)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	846
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

STK25_HUMAN
θ value	8.3442e-30 (rank : 90)	NC score	0.956176 (rank : 86)
Query Neighborhood Hits	1311	Target Neighborhood Hits	853	Shared Neighborhood Hits	838
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

PAK2_HUMAN
θ value	1.08979e-29 (rank : 91)	NC score	0.961773 (rank : 48)
Query Neighborhood Hits	1311	Target Neighborhood Hits	862	Shared Neighborhood Hits	848
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

STK3_MOUSE
θ value	1.08979e-29 (rank : 92)	NC score	0.958738 (rank : 65)
Query Neighborhood Hits	1311	Target Neighborhood Hits	869	Shared Neighborhood Hits	839
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

PAK4_HUMAN
θ value	1.4233e-29 (rank : 93)	NC score	0.961474 (rank : 50)
Query Neighborhood Hits	1311	Target Neighborhood Hits	924	Shared Neighborhood Hits	847
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PLK1_MOUSE
θ value	1.4233e-29 (rank : 94)	NC score	0.963332 (rank : 35)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	835
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

KCC2B_HUMAN
θ value	1.85889e-29 (rank : 95)	NC score	0.938323 (rank : 213)
Query Neighborhood Hits	1311	Target Neighborhood Hits	866	Shared Neighborhood Hits	822
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	1.85889e-29 (rank : 96)	NC score	0.936577 (rank : 230)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	822
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

M3K5_HUMAN
θ value	1.85889e-29 (rank : 97)	NC score	0.958429 (rank : 75)
Query Neighborhood Hits	1311	Target Neighborhood Hits	868	Shared Neighborhood Hits	841
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

AURKC_MOUSE
θ value	2.42779e-29 (rank : 98)	NC score	0.964754 (rank : 25)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	842
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

DCAK3_MOUSE
θ value	2.42779e-29 (rank : 99)	NC score	0.952046 (rank : 109)
Query Neighborhood Hits	1311	Target Neighborhood Hits	922	Shared Neighborhood Hits	855
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KCC2A_MOUSE
θ value	2.42779e-29 (rank : 100)	NC score	0.938776 (rank : 211)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	819
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

M3K5_MOUSE
θ value	2.42779e-29 (rank : 101)	NC score	0.958532 (rank : 71)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	838
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

DCAK3_HUMAN
θ value	4.14116e-29 (rank : 102)	NC score	0.952035 (rank : 110)
Query Neighborhood Hits	1311	Target Neighborhood Hits	888	Shared Neighborhood Hits	845
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

M4K4_HUMAN
θ value	4.14116e-29 (rank : 103)	NC score	0.920234 (rank : 341)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1589	Shared Neighborhood Hits	996
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

KCC1A_HUMAN
θ value	5.40856e-29 (rank : 104)	NC score	0.947616 (rank : 135)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	836
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_MOUSE
θ value	5.40856e-29 (rank : 105)	NC score	0.947738 (rank : 133)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	836
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

M3K15_HUMAN
θ value	5.40856e-29 (rank : 106)	NC score	0.959778 (rank : 59)
Query Neighborhood Hits	1311	Target Neighborhood Hits	914	Shared Neighborhood Hits	852
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

PAK4_MOUSE
θ value	5.40856e-29 (rank : 107)	NC score	0.957545 (rank : 80)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1098	Shared Neighborhood Hits	845
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

STK4_HUMAN
θ value	5.40856e-29 (rank : 108)	NC score	0.958657 (rank : 70)
Query Neighborhood Hits	1311	Target Neighborhood Hits	870	Shared Neighborhood Hits	842
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
θ value	5.40856e-29 (rank : 109)	NC score	0.958664 (rank : 69)
Query Neighborhood Hits	1311	Target Neighborhood Hits	873	Shared Neighborhood Hits	845
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

SGK2_MOUSE
θ value	9.2256e-29 (rank : 110)	NC score	0.936012 (rank : 237)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	829
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

PAK1_MOUSE
θ value	1.2049e-28 (rank : 111)	NC score	0.959412 (rank : 63)
Query Neighborhood Hits	1311	Target Neighborhood Hits	878	Shared Neighborhood Hits	841
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

PAK6_HUMAN
θ value	1.2049e-28 (rank : 112)	NC score	0.962186 (rank : 44)
Query Neighborhood Hits	1311	Target Neighborhood Hits	915	Shared Neighborhood Hits	841
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

TAOK2_MOUSE
θ value	1.2049e-28 (rank : 113)	NC score	0.929502 (rank : 287)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1373	Shared Neighborhood Hits	992
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK2_HUMAN
θ value	1.57365e-28 (rank : 114)	NC score	0.940809 (rank : 196)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1172	Shared Neighborhood Hits	955
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

M4K4_MOUSE
θ value	2.05525e-28 (rank : 115)	NC score	0.918983 (rank : 351)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1560	Shared Neighborhood Hits	997
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

PAK7_HUMAN
θ value	2.68423e-28 (rank : 116)	NC score	0.962762 (rank : 39)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	842
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PAK7_MOUSE
θ value	2.68423e-28 (rank : 117)	NC score	0.962381 (rank : 43)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	842
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PDPK1_HUMAN
θ value	2.68423e-28 (rank : 118)	NC score	0.952456 (rank : 105)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	836
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	2.68423e-28 (rank : 119)	NC score	0.952482 (rank : 104)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	836
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

SGK2_HUMAN
θ value	2.68423e-28 (rank : 120)	NC score	0.934955 (rank : 250)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ULK2_HUMAN
θ value	2.68423e-28 (rank : 121)	NC score	0.962932 (rank : 36)
Query Neighborhood Hits	1311	Target Neighborhood Hits	979	Shared Neighborhood Hits	845
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

ULK2_MOUSE
θ value	2.68423e-28 (rank : 122)	NC score	0.964114 (rank : 30)
Query Neighborhood Hits	1311	Target Neighborhood Hits	943	Shared Neighborhood Hits	848
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

AURKB_MOUSE
θ value	3.50572e-28 (rank : 123)	NC score	0.961962 (rank : 46)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

HUNK_HUMAN
θ value	3.50572e-28 (rank : 124)	NC score	0.958721 (rank : 66)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	844
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

SGK1_HUMAN
θ value	3.50572e-28 (rank : 125)	NC score	0.937784 (rank : 219)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	834
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

STK6_HUMAN
θ value	3.50572e-28 (rank : 126)	NC score	0.964753 (rank : 26)
Query Neighborhood Hits	1311	Target Neighborhood Hits	916	Shared Neighborhood Hits	852
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

KPCD2_HUMAN
θ value	4.57862e-28 (rank : 127)	NC score	0.942379 (rank : 182)
Query Neighborhood Hits	1311	Target Neighborhood Hits	910	Shared Neighborhood Hits	835
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

SGK1_MOUSE
θ value	5.97985e-28 (rank : 128)	NC score	0.937333 (rank : 225)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	834
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

AURKB_HUMAN
θ value	7.80994e-28 (rank : 129)	NC score	0.961267 (rank : 51)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	841
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

CSKP_HUMAN
θ value	7.80994e-28 (rank : 130)	NC score	0.887625 (rank : 495)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1022	Shared Neighborhood Hits	814
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	7.80994e-28 (rank : 131)	NC score	0.890271 (rank : 491)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1027	Shared Neighborhood Hits	814
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

KPCD1_HUMAN
θ value	7.80994e-28 (rank : 132)	NC score	0.940550 (rank : 199)
Query Neighborhood Hits	1311	Target Neighborhood Hits	901	Shared Neighborhood Hits	833
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

AURKC_HUMAN
θ value	1.02001e-27 (rank : 133)	NC score	0.964245 (rank : 29)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	841
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

M3K3_HUMAN
θ value	1.02001e-27 (rank : 134)	NC score	0.962400 (rank : 42)
Query Neighborhood Hits	1311	Target Neighborhood Hits	885	Shared Neighborhood Hits	844
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

M4K5_HUMAN
θ value	1.02001e-27 (rank : 135)	NC score	0.940076 (rank : 204)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	827
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

KPCD1_MOUSE
θ value	1.33217e-27 (rank : 136)	NC score	0.940121 (rank : 203)
Query Neighborhood Hits	1311	Target Neighborhood Hits	891	Shared Neighborhood Hits	834
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

M3K3_MOUSE
θ value	1.33217e-27 (rank : 137)	NC score	0.962132 (rank : 45)
Query Neighborhood Hits	1311	Target Neighborhood Hits	876	Shared Neighborhood Hits	841
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

E2AK2_MOUSE
θ value	1.73987e-27 (rank : 138)	NC score	0.965188 (rank : 22)
Query Neighborhood Hits	1311	Target Neighborhood Hits	864	Shared Neighborhood Hits	835
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

HUNK_MOUSE
θ value	1.73987e-27 (rank : 139)	NC score	0.958475 (rank : 74)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	840
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

NUAK2_MOUSE
θ value	1.73987e-27 (rank : 140)	NC score	0.957879 (rank : 77)
Query Neighborhood Hits	1311	Target Neighborhood Hits	878	Shared Neighborhood Hits	843
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

BRSK1_HUMAN
θ value	2.96777e-27 (rank : 141)	NC score	0.951701 (rank : 111)
Query Neighborhood Hits	1311	Target Neighborhood Hits	942	Shared Neighborhood Hits	836
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

M4K5_MOUSE
θ value	2.96777e-27 (rank : 142)	NC score	0.941394 (rank : 189)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	823
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

M3K2_HUMAN
θ value	3.87602e-27 (rank : 143)	NC score	0.960287 (rank : 56)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	837
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

TAOK1_MOUSE
θ value	3.87602e-27 (rank : 144)	NC score	0.906734 (rank : 430)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1720	Shared Neighborhood Hits	1062
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

YSK4_HUMAN
θ value	3.87602e-27 (rank : 145)	NC score	0.962893 (rank : 38)
Query Neighborhood Hits	1311	Target Neighborhood Hits	921	Shared Neighborhood Hits	855
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

TAOK1_HUMAN
θ value	5.06226e-27 (rank : 146)	NC score	0.906325 (rank : 436)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1734	Shared Neighborhood Hits	1060
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

ULK3_MOUSE
θ value	5.06226e-27 (rank : 147)	NC score	0.964350 (rank : 27)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	839
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PRKX_HUMAN
θ value	6.61148e-27 (rank : 148)	NC score	0.942092 (rank : 185)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	835
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

SN1L1_MOUSE
θ value	6.61148e-27 (rank : 149)	NC score	0.953120 (rank : 100)
Query Neighborhood Hits	1311	Target Neighborhood Hits	895	Shared Neighborhood Hits	840
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

TAOK3_HUMAN
θ value	6.61148e-27 (rank : 150)	NC score	0.918054 (rank : 358)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1494	Shared Neighborhood Hits	1018
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

GAK_HUMAN
θ value	8.63488e-27 (rank : 151)	NC score	0.898137 (rank : 469)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1028	Shared Neighborhood Hits	822
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

M4K1_HUMAN
θ value	8.63488e-27 (rank : 152)	NC score	0.947203 (rank : 138)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	836
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

KPSH1_HUMAN
θ value	1.12775e-26 (rank : 153)	NC score	0.945200 (rank : 158)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	830
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
θ value	1.12775e-26 (rank : 154)	NC score	0.945676 (rank : 154)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	830
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

TAOK3_MOUSE
θ value	1.12775e-26 (rank : 155)	NC score	0.920136 (rank : 342)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1458	Shared Neighborhood Hits	1005
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

GAK_MOUSE
θ value	1.47289e-26 (rank : 156)	NC score	0.893212 (rank : 485)
Query Neighborhood Hits	1311	Target Neighborhood Hits	964	Shared Neighborhood Hits	815
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

CDK3_HUMAN
θ value	1.92365e-26 (rank : 157)	NC score	0.932711 (rank : 263)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	834
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

DCAK2_HUMAN
θ value	1.92365e-26 (rank : 158)	NC score	0.933846 (rank : 256)
Query Neighborhood Hits	1311	Target Neighborhood Hits	862	Shared Neighborhood Hits	827
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KCC1G_MOUSE
θ value	1.92365e-26 (rank : 159)	NC score	0.947000 (rank : 140)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	835
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

ST32A_MOUSE
θ value	2.51237e-26 (rank : 160)	NC score	0.947915 (rank : 132)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

TNIK_HUMAN
θ value	2.51237e-26 (rank : 161)	NC score	0.931587 (rank : 270)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1570	Shared Neighborhood Hits	980
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TSSK6_MOUSE
θ value	2.51237e-26 (rank : 162)	NC score	0.947428 (rank : 137)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	820
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

DCAK2_MOUSE
θ value	3.28125e-26 (rank : 163)	NC score	0.935169 (rank : 249)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	829
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

E2AK2_HUMAN
θ value	3.28125e-26 (rank : 164)	NC score	0.957812 (rank : 78)
Query Neighborhood Hits	1311	Target Neighborhood Hits	856	Shared Neighborhood Hits	832
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

KCC1G_HUMAN
θ value	3.28125e-26 (rank : 165)	NC score	0.946827 (rank : 144)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	835
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

SN1L1_HUMAN
θ value	3.28125e-26 (rank : 166)	NC score	0.951245 (rank : 113)
Query Neighborhood Hits	1311	Target Neighborhood Hits	911	Shared Neighborhood Hits	842
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

CDKL1_HUMAN
θ value	4.28545e-26 (rank : 167)	NC score	0.936200 (rank : 233)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

M3K13_HUMAN
θ value	4.28545e-26 (rank : 168)	NC score	0.931310 (rank : 273)
Query Neighborhood Hits	1311	Target Neighborhood Hits	911	Shared Neighborhood Hits	843
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

CDK2_HUMAN
θ value	5.59698e-26 (rank : 169)	NC score	0.932992 (rank : 261)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	830
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

M3K2_MOUSE
θ value	5.59698e-26 (rank : 170)	NC score	0.958524 (rank : 72)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	831
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

PMYT1_MOUSE
θ value	7.30988e-26 (rank : 171)	NC score	0.935610 (rank : 246)
Query Neighborhood Hits	1311	Target Neighborhood Hits	910	Shared Neighborhood Hits	826
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PRKY_HUMAN
θ value	7.30988e-26 (rank : 172)	NC score	0.950425 (rank : 120)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	835
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

M3K12_HUMAN
θ value	9.54697e-26 (rank : 173)	NC score	0.924434 (rank : 315)
Query Neighborhood Hits	1311	Target Neighborhood Hits	940	Shared Neighborhood Hits	847
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	9.54697e-26 (rank : 174)	NC score	0.924398 (rank : 316)
Query Neighborhood Hits	1311	Target Neighborhood Hits	957	Shared Neighborhood Hits	851
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

AAPK1_HUMAN
θ value	1.24688e-25 (rank : 175)	NC score	0.955201 (rank : 95)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	837
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	1.24688e-25 (rank : 176)	NC score	0.954986 (rank : 96)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	837
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

K0999_MOUSE
θ value	1.24688e-25 (rank : 177)	NC score	0.946721 (rank : 145)
Query Neighborhood Hits	1311	Target Neighborhood Hits	931	Shared Neighborhood Hits	838
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

KCC1D_HUMAN
θ value	1.24688e-25 (rank : 178)	NC score	0.943781 (rank : 172)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

KCC1D_MOUSE
θ value	1.24688e-25 (rank : 179)	NC score	0.943797 (rank : 171)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	834
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KPCD3_HUMAN
θ value	1.24688e-25 (rank : 180)	NC score	0.936740 (rank : 229)
Query Neighborhood Hits	1311	Target Neighborhood Hits	895	Shared Neighborhood Hits	828
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KPCD3_MOUSE
θ value	1.24688e-25 (rank : 181)	NC score	0.936432 (rank : 232)
Query Neighborhood Hits	1311	Target Neighborhood Hits	901	Shared Neighborhood Hits	828
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

STK6_MOUSE
θ value	1.24688e-25 (rank : 182)	NC score	0.963887 (rank : 33)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	846
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

TSSK1_MOUSE
θ value	1.24688e-25 (rank : 183)	NC score	0.947489 (rank : 136)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	822
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

BRSK2_HUMAN
θ value	1.62847e-25 (rank : 184)	NC score	0.951096 (rank : 115)
Query Neighborhood Hits	1311	Target Neighborhood Hits	897	Shared Neighborhood Hits	835
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

CDC2_MOUSE
θ value	1.62847e-25 (rank : 185)	NC score	0.935969 (rank : 238)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	835
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

DCAK1_MOUSE
θ value	1.62847e-25 (rank : 186)	NC score	0.935677 (rank : 243)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	830
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

ICK_MOUSE
θ value	1.62847e-25 (rank : 187)	NC score	0.933654 (rank : 258)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	834
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

KPCL_MOUSE
θ value	1.62847e-25 (rank : 188)	NC score	0.919614 (rank : 347)
Query Neighborhood Hits	1311	Target Neighborhood Hits	891	Shared Neighborhood Hits	822
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MINK1_HUMAN
θ value	1.62847e-25 (rank : 189)	NC score	0.931418 (rank : 271)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1477	Shared Neighborhood Hits	964
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	1.62847e-25 (rank : 190)	NC score	0.932115 (rank : 267)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1451	Shared Neighborhood Hits	962
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MYO3B_HUMAN
θ value	1.62847e-25 (rank : 191)	NC score	0.825850 (rank : 595)
Query Neighborhood Hits	1311	Target Neighborhood Hits	923	Shared Neighborhood Hits	847
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

TSSK6_HUMAN
θ value	1.62847e-25 (rank : 192)	NC score	0.946494 (rank : 149)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	821
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

CDKL1_MOUSE
θ value	2.12685e-25 (rank : 193)	NC score	0.935643 (rank : 244)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	825
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

STK33_HUMAN
θ value	2.12685e-25 (rank : 194)	NC score	0.961579 (rank : 49)
Query Neighborhood Hits	1311	Target Neighborhood Hits	879	Shared Neighborhood Hits	845
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

K0999_HUMAN
θ value	2.77775e-25 (rank : 195)	NC score	0.946913 (rank : 141)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	833
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

M3K1_MOUSE
θ value	2.77775e-25 (rank : 196)	NC score	0.962670 (rank : 41)
Query Neighborhood Hits	1311	Target Neighborhood Hits	952	Shared Neighborhood Hits	845
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K6_HUMAN
θ value	2.77775e-25 (rank : 197)	NC score	0.960485 (rank : 54)
Query Neighborhood Hits	1311	Target Neighborhood Hits	889	Shared Neighborhood Hits	837
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

ST32C_MOUSE
θ value	2.77775e-25 (rank : 198)	NC score	0.940155 (rank : 201)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	815
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

CDC2_HUMAN
θ value	3.62785e-25 (rank : 199)	NC score	0.936863 (rank : 227)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	836
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

KCC1B_MOUSE
θ value	3.62785e-25 (rank : 200)	NC score	0.945154 (rank : 160)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	836
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

CDK2_MOUSE
θ value	4.73814e-25 (rank : 201)	NC score	0.932533 (rank : 264)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	825
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

SN1L2_MOUSE
θ value	4.73814e-25 (rank : 202)	NC score	0.948264 (rank : 128)
Query Neighborhood Hits	1311	Target Neighborhood Hits	944	Shared Neighborhood Hits	844
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

ST32A_HUMAN
θ value	4.73814e-25 (rank : 203)	NC score	0.945255 (rank : 156)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	826
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

KCC1B_HUMAN
θ value	6.18819e-25 (rank : 204)	NC score	0.944712 (rank : 164)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	836
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KS6A5_MOUSE
θ value	6.18819e-25 (rank : 205)	NC score	0.928045 (rank : 297)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	837
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

SNRK_HUMAN
θ value	6.18819e-25 (rank : 206)	NC score	0.950887 (rank : 117)
Query Neighborhood Hits	1311	Target Neighborhood Hits	855	Shared Neighborhood Hits	823
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

SNRK_MOUSE
θ value	6.18819e-25 (rank : 207)	NC score	0.950323 (rank : 122)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	820
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

TSSK1_HUMAN
θ value	6.18819e-25 (rank : 208)	NC score	0.937944 (rank : 218)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	815
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

DCAK1_HUMAN
θ value	8.08199e-25 (rank : 209)	NC score	0.935639 (rank : 245)
Query Neighborhood Hits	1311	Target Neighborhood Hits	877	Shared Neighborhood Hits	833
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

MYLK_MOUSE
θ value	8.08199e-25 (rank : 210)	NC score	0.867621 (rank : 523)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1489	Shared Neighborhood Hits	867
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

ST32C_HUMAN
θ value	8.08199e-25 (rank : 211)	NC score	0.937407 (rank : 224)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	818
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

CDK5_HUMAN
θ value	1.05554e-24 (rank : 212)	NC score	0.923209 (rank : 319)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	820
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	1.05554e-24 (rank : 213)	NC score	0.923162 (rank : 320)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	820
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CDKL4_MOUSE
θ value	1.05554e-24 (rank : 214)	NC score	0.939884 (rank : 205)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	827
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KPCL_HUMAN
θ value	1.05554e-24 (rank : 215)	NC score	0.916192 (rank : 374)
Query Neighborhood Hits	1311	Target Neighborhood Hits	887	Shared Neighborhood Hits	821
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KS6A5_HUMAN
θ value	1.05554e-24 (rank : 216)	NC score	0.932147 (rank : 266)
Query Neighborhood Hits	1311	Target Neighborhood Hits	855	Shared Neighborhood Hits	839
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

ST32B_MOUSE
θ value	1.05554e-24 (rank : 217)	NC score	0.941788 (rank : 187)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	821
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

CD2L2_HUMAN
θ value	1.37858e-24 (rank : 218)	NC score	0.907958 (rank : 424)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1439	Shared Neighborhood Hits	975
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

KPCE_HUMAN
θ value	1.37858e-24 (rank : 219)	NC score	0.920066 (rank : 343)
Query Neighborhood Hits	1311	Target Neighborhood Hits	906	Shared Neighborhood Hits	826
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

RAF1_HUMAN
θ value	1.37858e-24 (rank : 220)	NC score	0.912850 (rank : 397)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	837
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

SN1L2_HUMAN
θ value	1.37858e-24 (rank : 221)	NC score	0.948594 (rank : 126)
Query Neighborhood Hits	1311	Target Neighborhood Hits	964	Shared Neighborhood Hits	853
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

ST17B_MOUSE
θ value	1.37858e-24 (rank : 222)	NC score	0.952362 (rank : 107)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ICK_HUMAN
θ value	1.80048e-24 (rank : 223)	NC score	0.932856 (rank : 262)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	833
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

CD2L1_HUMAN
θ value	2.35151e-24 (rank : 224)	NC score	0.905069 (rank : 442)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1467	Shared Neighborhood Hits	980
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

KPCE_MOUSE
θ value	2.35151e-24 (rank : 225)	NC score	0.920542 (rank : 339)
Query Neighborhood Hits	1311	Target Neighborhood Hits	906	Shared Neighborhood Hits	825
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KS6A4_HUMAN
θ value	2.35151e-24 (rank : 226)	NC score	0.928564 (rank : 294)
Query Neighborhood Hits	1311	Target Neighborhood Hits	868	Shared Neighborhood Hits	842
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

OXSR1_MOUSE
θ value	2.35151e-24 (rank : 227)	NC score	0.955771 (rank : 89)
Query Neighborhood Hits	1311	Target Neighborhood Hits	865	Shared Neighborhood Hits	840
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PMYT1_HUMAN
θ value	2.35151e-24 (rank : 228)	NC score	0.929439 (rank : 289)
Query Neighborhood Hits	1311	Target Neighborhood Hits	814	Shared Neighborhood Hits	802
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PRKX_MOUSE
θ value	2.35151e-24 (rank : 229)	NC score	0.941127 (rank : 193)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	838
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

BRAF1_HUMAN
θ value	3.07116e-24 (rank : 230)	NC score	0.912583 (rank : 400)
Query Neighborhood Hits	1311	Target Neighborhood Hits	883	Shared Neighborhood Hits	828
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

MOK_HUMAN
θ value	3.07116e-24 (rank : 231)	NC score	0.909835 (rank : 415)
Query Neighborhood Hits	1311	Target Neighborhood Hits	807	Shared Neighborhood Hits	799
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MYO3A_HUMAN
θ value	3.07116e-24 (rank : 232)	NC score	0.830442 (rank : 581)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1033	Shared Neighborhood Hits	887
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

MYO3A_MOUSE
θ value	3.07116e-24 (rank : 233)	NC score	0.836989 (rank : 568)
Query Neighborhood Hits	1311	Target Neighborhood Hits	902	Shared Neighborhood Hits	841
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

STK16_MOUSE
θ value	3.07116e-24 (rank : 234)	NC score	0.943556 (rank : 174)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	817
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

KPCT_HUMAN
θ value	4.01107e-24 (rank : 235)	NC score	0.929680 (rank : 286)
Query Neighborhood Hits	1311	Target Neighborhood Hits	897	Shared Neighborhood Hits	835
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

M4K1_MOUSE
θ value	4.01107e-24 (rank : 236)	NC score	0.946834 (rank : 143)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	836
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

MYLK_HUMAN
θ value	4.01107e-24 (rank : 237)	NC score	0.869296 (rank : 515)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1328	Shared Neighborhood Hits	853
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

CHK2_HUMAN
θ value	5.23862e-24 (rank : 238)	NC score	0.944511 (rank : 166)
Query Neighborhood Hits	1311	Target Neighborhood Hits	859	Shared Neighborhood Hits	830
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

KS6A4_MOUSE
θ value	5.23862e-24 (rank : 239)	NC score	0.929015 (rank : 290)
Query Neighborhood Hits	1311	Target Neighborhood Hits	866	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

OXSR1_HUMAN
θ value	5.23862e-24 (rank : 240)	NC score	0.955812 (rank : 88)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	843
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

ST32B_HUMAN
θ value	5.23862e-24 (rank : 241)	NC score	0.940864 (rank : 195)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

TSSK4_MOUSE
θ value	6.84181e-24 (rank : 242)	NC score	0.955232 (rank : 94)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

CDKL3_MOUSE
θ value	8.93572e-24 (rank : 243)	NC score	0.944845 (rank : 162)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	834
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

CD2L1_MOUSE
θ value	1.16704e-23 (rank : 244)	NC score	0.904236 (rank : 445)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1463	Shared Neighborhood Hits	980
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CDKL5_HUMAN
θ value	1.16704e-23 (rank : 245)	NC score	0.933614 (rank : 259)
Query Neighborhood Hits	1311	Target Neighborhood Hits	967	Shared Neighborhood Hits	854
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

STK11_HUMAN
θ value	1.16704e-23 (rank : 246)	NC score	0.958515 (rank : 73)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	825
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

AAPK2_HUMAN
θ value	1.5242e-23 (rank : 247)	NC score	0.952835 (rank : 103)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	836
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

CDKL3_HUMAN
θ value	1.5242e-23 (rank : 248)	NC score	0.945175 (rank : 159)
Query Neighborhood Hits	1311	Target Neighborhood Hits	853	Shared Neighborhood Hits	836
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CHK2_MOUSE
θ value	1.5242e-23 (rank : 249)	NC score	0.945244 (rank : 157)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

KPCA_HUMAN
θ value	1.5242e-23 (rank : 250)	NC score	0.901588 (rank : 455)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1070	Shared Neighborhood Hits	828
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
θ value	1.5242e-23 (rank : 251)	NC score	0.903633 (rank : 448)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1067	Shared Neighborhood Hits	824
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCI_HUMAN
θ value	1.5242e-23 (rank : 252)	NC score	0.922093 (rank : 327)
Query Neighborhood Hits	1311	Target Neighborhood Hits	885	Shared Neighborhood Hits	834
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	1.5242e-23 (rank : 253)	NC score	0.921944 (rank : 329)
Query Neighborhood Hits	1311	Target Neighborhood Hits	888	Shared Neighborhood Hits	834
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

MELK_MOUSE
θ value	1.5242e-23 (rank : 254)	NC score	0.949444 (rank : 123)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	833
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

PKN1_HUMAN
θ value	1.5242e-23 (rank : 255)	NC score	0.929738 (rank : 285)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	845
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

ST17B_HUMAN
θ value	1.5242e-23 (rank : 256)	NC score	0.948177 (rank : 130)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	823
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MELK_HUMAN
θ value	1.99067e-23 (rank : 257)	NC score	0.948252 (rank : 129)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	834
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

MOK_MOUSE
θ value	1.99067e-23 (rank : 258)	NC score	0.908371 (rank : 422)
Query Neighborhood Hits	1311	Target Neighborhood Hits	796	Shared Neighborhood Hits	793
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

PKN1_MOUSE
θ value	1.99067e-23 (rank : 259)	NC score	0.930161 (rank : 284)
Query Neighborhood Hits	1311	Target Neighborhood Hits	888	Shared Neighborhood Hits	840
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

TSSK4_HUMAN
θ value	1.99067e-23 (rank : 260)	NC score	0.952397 (rank : 106)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	833
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

AAK1_HUMAN
θ value	2.59989e-23 (rank : 261)	NC score	0.896651 (rank : 475)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1077	Shared Neighborhood Hits	802
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AAK1_MOUSE
θ value	2.59989e-23 (rank : 262)	NC score	0.898722 (rank : 468)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1051	Shared Neighborhood Hits	801
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

CDK10_HUMAN
θ value	2.59989e-23 (rank : 263)	NC score	0.918805 (rank : 354)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	827
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

GRK6_MOUSE
θ value	2.59989e-23 (rank : 264)	NC score	0.924938 (rank : 313)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	820
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MAST2_MOUSE
θ value	2.59989e-23 (rank : 265)	NC score	0.915946 (rank : 382)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1110	Shared Neighborhood Hits	866
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

RAF1_MOUSE
θ value	2.59989e-23 (rank : 266)	NC score	0.912632 (rank : 399)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	838
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

STK16_HUMAN
θ value	2.59989e-23 (rank : 267)	NC score	0.945003 (rank : 161)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	822
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

CDKL4_HUMAN
θ value	3.39556e-23 (rank : 268)	NC score	0.935714 (rank : 242)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	822
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

GRK6_HUMAN
θ value	4.43474e-23 (rank : 269)	NC score	0.925651 (rank : 307)
Query Neighborhood Hits	1311	Target Neighborhood Hits	823	Shared Neighborhood Hits	821
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KCC4_HUMAN
θ value	4.43474e-23 (rank : 270)	NC score	0.940551 (rank : 198)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	827
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_MOUSE
θ value	4.43474e-23 (rank : 271)	NC score	0.940172 (rank : 200)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	849
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

MRCKB_HUMAN
θ value	4.43474e-23 (rank : 272)	NC score	0.808321 (rank : 624)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2239	Shared Neighborhood Hits	1075
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PCTK3_MOUSE
θ value	4.43474e-23 (rank : 273)	NC score	0.924288 (rank : 317)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	822
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

PKN3_MOUSE
θ value	4.43474e-23 (rank : 274)	NC score	0.926293 (rank : 305)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	856
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

KPCT_MOUSE
θ value	7.56453e-23 (rank : 275)	NC score	0.928708 (rank : 292)
Query Neighborhood Hits	1311	Target Neighborhood Hits	895	Shared Neighborhood Hits	832
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

MAST2_HUMAN
θ value	7.56453e-23 (rank : 276)	NC score	0.914498 (rank : 389)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1189	Shared Neighborhood Hits	873
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MYLK2_HUMAN
θ value	7.56453e-23 (rank : 277)	NC score	0.946267 (rank : 151)
Query Neighborhood Hits	1311	Target Neighborhood Hits	920	Shared Neighborhood Hits	820
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

RK_MOUSE
θ value	7.56453e-23 (rank : 278)	NC score	0.930458 (rank : 281)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	821
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

TSSK3_MOUSE
θ value	7.56453e-23 (rank : 279)	NC score	0.936473 (rank : 231)
Query Neighborhood Hits	1311	Target Neighborhood Hits	806	Shared Neighborhood Hits	802
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

MAK_MOUSE
θ value	9.87957e-23 (rank : 280)	NC score	0.930827 (rank : 277)
Query Neighborhood Hits	1311	Target Neighborhood Hits	873	Shared Neighborhood Hits	833
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

OBSCN_HUMAN
θ value	9.87957e-23 (rank : 281)	NC score	0.830734 (rank : 580)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1931	Shared Neighborhood Hits	882
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PKN2_HUMAN
θ value	9.87957e-23 (rank : 282)	NC score	0.931809 (rank : 269)
Query Neighborhood Hits	1311	Target Neighborhood Hits	892	Shared Neighborhood Hits	846
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_MOUSE
θ value	9.87957e-23 (rank : 283)	NC score	0.931936 (rank : 268)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	850
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

ST17A_HUMAN
θ value	9.87957e-23 (rank : 284)	NC score	0.946407 (rank : 150)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	825
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

STK39_HUMAN
θ value	9.87957e-23 (rank : 285)	NC score	0.955454 (rank : 90)
Query Neighborhood Hits	1311	Target Neighborhood Hits	882	Shared Neighborhood Hits	845
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	9.87957e-23 (rank : 286)	NC score	0.955364 (rank : 91)
Query Neighborhood Hits	1311	Target Neighborhood Hits	915	Shared Neighborhood Hits	853
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

TSSK2_HUMAN
θ value	9.87957e-23 (rank : 287)	NC score	0.944610 (rank : 165)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

BMP2K_HUMAN
θ value	1.29031e-22 (rank : 288)	NC score	0.905554 (rank : 440)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	791
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMP2K_MOUSE
θ value	1.29031e-22 (rank : 289)	NC score	0.903807 (rank : 446)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	790
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

DAPK3_HUMAN
θ value	1.29031e-22 (rank : 290)	NC score	0.946506 (rank : 148)
Query Neighborhood Hits	1311	Target Neighborhood Hits	945	Shared Neighborhood Hits	862
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KPCZ_HUMAN
θ value	1.6852e-22 (rank : 291)	NC score	0.916161 (rank : 377)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	830
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
θ value	1.6852e-22 (rank : 292)	NC score	0.916198 (rank : 373)
Query Neighborhood Hits	1311	Target Neighborhood Hits	882	Shared Neighborhood Hits	831
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

PCTK3_HUMAN
θ value	1.6852e-22 (rank : 293)	NC score	0.921265 (rank : 332)
Query Neighborhood Hits	1311	Target Neighborhood Hits	827	Shared Neighborhood Hits	816
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

RK_HUMAN
θ value	1.6852e-22 (rank : 294)	NC score	0.928912 (rank : 291)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KGP2_MOUSE
θ value	2.20094e-22 (rank : 295)	NC score	0.923153 (rank : 321)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1029	Shared Neighborhood Hits	876
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

TSSK3_HUMAN
θ value	2.20094e-22 (rank : 296)	NC score	0.935773 (rank : 241)
Query Neighborhood Hits	1311	Target Neighborhood Hits	806	Shared Neighborhood Hits	803
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

KGP2_HUMAN
θ value	2.87452e-22 (rank : 297)	NC score	0.923618 (rank : 318)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1023	Shared Neighborhood Hits	878
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

KPSH2_HUMAN
θ value	2.87452e-22 (rank : 298)	NC score	0.943426 (rank : 175)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

MAK_HUMAN
θ value	2.87452e-22 (rank : 299)	NC score	0.929474 (rank : 288)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	831
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

TSSK2_MOUSE
θ value	3.75424e-22 (rank : 300)	NC score	0.936181 (rank : 234)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	811
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

DAPK3_MOUSE
θ value	4.9032e-22 (rank : 301)	NC score	0.947702 (rank : 134)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

PKN3_HUMAN
θ value	4.9032e-22 (rank : 302)	NC score	0.926100 (rank : 306)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	836
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

ROCK1_HUMAN
θ value	4.9032e-22 (rank : 303)	NC score	0.828673 (rank : 585)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2000	Shared Neighborhood Hits	1056
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	4.9032e-22 (rank : 304)	NC score	0.813900 (rank : 613)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2126	Shared Neighborhood Hits	1072
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

CDK9_MOUSE
θ value	6.40375e-22 (rank : 305)	NC score	0.916683 (rank : 369)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	817
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

ROCK2_HUMAN
θ value	6.40375e-22 (rank : 306)	NC score	0.832784 (rank : 572)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2073	Shared Neighborhood Hits	1069
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

WNK1_HUMAN
θ value	6.40375e-22 (rank : 307)	NC score	0.912947 (rank : 396)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1158	Shared Neighborhood Hits	800
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	6.40375e-22 (rank : 308)	NC score	0.911361 (rank : 408)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1179	Shared Neighborhood Hits	809
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

CDK9_HUMAN
θ value	8.36355e-22 (rank : 309)	NC score	0.917153 (rank : 366)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	817
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

ULK4_MOUSE
θ value	8.36355e-22 (rank : 310)	NC score	0.935423 (rank : 248)
Query Neighborhood Hits	1311	Target Neighborhood Hits	793	Shared Neighborhood Hits	778
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

TITIN_HUMAN
θ value	1.09232e-21 (rank : 311)	NC score	0.722421 (rank : 774)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2923	Shared Neighborhood Hits	995
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

CDKL2_MOUSE
θ value	1.42661e-21 (rank : 312)	NC score	0.938624 (rank : 212)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	835
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

IKKA_MOUSE
θ value	1.42661e-21 (rank : 313)	NC score	0.951063 (rank : 116)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	840
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

KKCC1_MOUSE
θ value	1.42661e-21 (rank : 314)	NC score	0.951360 (rank : 112)
Query Neighborhood Hits	1311	Target Neighborhood Hits	866	Shared Neighborhood Hits	836
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KKCC2_HUMAN
θ value	1.42661e-21 (rank : 315)	NC score	0.954535 (rank : 98)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	830
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	1.42661e-21 (rank : 316)	NC score	0.954599 (rank : 97)
Query Neighborhood Hits	1311	Target Neighborhood Hits	855	Shared Neighborhood Hits	831
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCB_HUMAN
θ value	1.42661e-21 (rank : 317)	NC score	0.893364 (rank : 484)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1121	Shared Neighborhood Hits	829
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	1.42661e-21 (rank : 318)	NC score	0.893794 (rank : 483)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1117	Shared Neighborhood Hits	828
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

MAST4_HUMAN
θ value	1.42661e-21 (rank : 319)	NC score	0.901167 (rank : 457)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1804	Shared Neighborhood Hits	907
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MK14_MOUSE
θ value	1.42661e-21 (rank : 320)	NC score	0.916174 (rank : 375)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	831
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

WNK3_HUMAN
θ value	1.42661e-21 (rank : 321)	NC score	0.922137 (rank : 326)
Query Neighborhood Hits	1311	Target Neighborhood Hits	948	Shared Neighborhood Hits	783
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

CD2L7_HUMAN
θ value	1.86321e-21 (rank : 322)	NC score	0.920912 (rank : 335)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1275	Shared Neighborhood Hits	882
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

CTRO_MOUSE
θ value	1.86321e-21 (rank : 323)	NC score	0.808958 (rank : 622)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2344	Shared Neighborhood Hits	1094
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

IKKA_HUMAN
θ value	1.86321e-21 (rank : 324)	NC score	0.950371 (rank : 121)
Query Neighborhood Hits	1311	Target Neighborhood Hits	863	Shared Neighborhood Hits	843
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MK14_HUMAN
θ value	2.43343e-21 (rank : 325)	NC score	0.916007 (rank : 380)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	831
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MRCKA_HUMAN
θ value	2.43343e-21 (rank : 326)	NC score	0.828850 (rank : 584)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1999	Shared Neighborhood Hits	1046
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MRCKB_MOUSE
θ value	2.43343e-21 (rank : 327)	NC score	0.816322 (rank : 611)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2180	Shared Neighborhood Hits	1068
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PCTK2_HUMAN
θ value	2.43343e-21 (rank : 328)	NC score	0.921644 (rank : 331)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	822
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

CDKL2_HUMAN
θ value	3.17815e-21 (rank : 329)	NC score	0.937295 (rank : 226)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	827
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

MAST3_HUMAN
θ value	3.17815e-21 (rank : 330)	NC score	0.916973 (rank : 368)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1128	Shared Neighborhood Hits	850
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

PCTK2_MOUSE
θ value	3.17815e-21 (rank : 331)	NC score	0.921657 (rank : 330)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

ROCK2_MOUSE
θ value	3.17815e-21 (rank : 332)	NC score	0.825545 (rank : 597)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2072	Shared Neighborhood Hits	1061
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

WNK4_MOUSE
θ value	3.17815e-21 (rank : 333)	NC score	0.911662 (rank : 406)
Query Neighborhood Hits	1311	Target Neighborhood Hits	961	Shared Neighborhood Hits	768
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ARAF_HUMAN
θ value	4.15078e-21 (rank : 334)	NC score	0.906286 (rank : 437)
Query Neighborhood Hits	1311	Target Neighborhood Hits	924	Shared Neighborhood Hits	835
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

PCTK1_HUMAN
θ value	4.15078e-21 (rank : 335)	NC score	0.922416 (rank : 324)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PHKG1_MOUSE
θ value	4.15078e-21 (rank : 336)	NC score	0.938072 (rank : 217)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	829
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

ULK3_HUMAN
θ value	4.15078e-21 (rank : 337)	NC score	0.963890 (rank : 32)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	825
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PCTK1_MOUSE
θ value	5.42112e-21 (rank : 338)	NC score	0.922672 (rank : 323)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	820
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

GRK4_MOUSE
θ value	7.0802e-21 (rank : 339)	NC score	0.916066 (rank : 379)
Query Neighborhood Hits	1311	Target Neighborhood Hits	808	Shared Neighborhood Hits	805
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

MAST1_MOUSE
θ value	7.0802e-21 (rank : 340)	NC score	0.910826 (rank : 412)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1123	Shared Neighborhood Hits	848
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KGP1A_HUMAN
θ value	9.24701e-21 (rank : 341)	NC score	0.920487 (rank : 340)
Query Neighborhood Hits	1311	Target Neighborhood Hits	901	Shared Neighborhood Hits	837
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	9.24701e-21 (rank : 342)	NC score	0.919898 (rank : 345)
Query Neighborhood Hits	1311	Target Neighborhood Hits	921	Shared Neighborhood Hits	842
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	9.24701e-21 (rank : 343)	NC score	0.919994 (rank : 344)
Query Neighborhood Hits	1311	Target Neighborhood Hits	922	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KPCD_HUMAN
θ value	9.24701e-21 (rank : 344)	NC score	0.922163 (rank : 325)
Query Neighborhood Hits	1311	Target Neighborhood Hits	900	Shared Neighborhood Hits	835
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
θ value	9.24701e-21 (rank : 345)	NC score	0.918916 (rank : 352)
Query Neighborhood Hits	1311	Target Neighborhood Hits	888	Shared Neighborhood Hits	828
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

MRCKG_HUMAN
θ value	9.24701e-21 (rank : 346)	NC score	0.875175 (rank : 512)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1519	Shared Neighborhood Hits	973
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PHKG2_MOUSE
θ value	1.2077e-20 (rank : 347)	NC score	0.944291 (rank : 169)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	832
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

STK38_HUMAN
θ value	1.2077e-20 (rank : 348)	NC score	0.899492 (rank : 465)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	818
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_MOUSE
θ value	1.2077e-20 (rank : 349)	NC score	0.899815 (rank : 464)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	818
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

WNK4_HUMAN
θ value	1.2077e-20 (rank : 350)	NC score	0.908087 (rank : 423)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1043	Shared Neighborhood Hits	775
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

DAPK2_MOUSE
θ value	1.5773e-20 (rank : 351)	NC score	0.945607 (rank : 155)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	827
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

M3K7_HUMAN
θ value	1.5773e-20 (rank : 352)	NC score	0.920984 (rank : 334)
Query Neighborhood Hits	1311	Target Neighborhood Hits	892	Shared Neighborhood Hits	845
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_MOUSE
θ value	1.5773e-20 (rank : 353)	NC score	0.921182 (rank : 333)
Query Neighborhood Hits	1311	Target Neighborhood Hits	892	Shared Neighborhood Hits	846
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MK03_HUMAN
θ value	1.5773e-20 (rank : 354)	NC score	0.911734 (rank : 405)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	829
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

MK03_MOUSE
θ value	1.5773e-20 (rank : 355)	NC score	0.910926 (rank : 410)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	829
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

KPCG_MOUSE
θ value	2.06002e-20 (rank : 356)	NC score	0.890874 (rank : 489)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1123	Shared Neighborhood Hits	826
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

MAST1_HUMAN
θ value	2.06002e-20 (rank : 357)	NC score	0.910994 (rank : 409)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1146	Shared Neighborhood Hits	860
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

WNK2_HUMAN
θ value	2.06002e-20 (rank : 358)	NC score	0.899084 (rank : 466)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1407	Shared Neighborhood Hits	800
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ARAF_MOUSE
θ value	2.69047e-20 (rank : 359)	NC score	0.905922 (rank : 439)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	832
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

GRK4_HUMAN
θ value	2.69047e-20 (rank : 360)	NC score	0.918701 (rank : 355)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	813
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

IKKB_HUMAN
θ value	2.69047e-20 (rank : 361)	NC score	0.950702 (rank : 119)
Query Neighborhood Hits	1311	Target Neighborhood Hits	980	Shared Neighborhood Hits	886
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KPCG_HUMAN
θ value	2.69047e-20 (rank : 362)	NC score	0.890379 (rank : 490)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1126	Shared Neighborhood Hits	827
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

CDK6_MOUSE
θ value	3.51386e-20 (rank : 363)	NC score	0.926569 (rank : 304)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	830
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

KKCC1_HUMAN
θ value	3.51386e-20 (rank : 364)	NC score	0.950845 (rank : 118)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	836
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

MLTK_HUMAN
θ value	3.51386e-20 (rank : 365)	NC score	0.906284 (rank : 438)
Query Neighborhood Hits	1311	Target Neighborhood Hits	911	Shared Neighborhood Hits	829
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

CD2L5_HUMAN
θ value	4.58923e-20 (rank : 366)	NC score	0.920748 (rank : 338)
Query Neighborhood Hits	1311	Target Neighborhood Hits	987	Shared Neighborhood Hits	843
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	4.58923e-20 (rank : 367)	NC score	0.920762 (rank : 337)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1011	Shared Neighborhood Hits	851
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CSK_HUMAN
θ value	4.58923e-20 (rank : 368)	NC score	0.834785 (rank : 570)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	831
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ST38L_HUMAN
θ value	4.58923e-20 (rank : 369)	NC score	0.898894 (rank : 467)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	809
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

CDK6_HUMAN
θ value	5.99374e-20 (rank : 370)	NC score	0.925426 (rank : 309)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	830
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CDK7_HUMAN
θ value	5.99374e-20 (rank : 371)	NC score	0.928184 (rank : 296)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	823
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

DAPK1_HUMAN
θ value	5.99374e-20 (rank : 372)	NC score	0.851661 (rank : 537)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1130	Shared Neighborhood Hits	835
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

MP2K3_MOUSE
θ value	5.99374e-20 (rank : 373)	NC score	0.938291 (rank : 215)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

PHKG1_HUMAN
θ value	5.99374e-20 (rank : 374)	NC score	0.938957 (rank : 209)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	830
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_HUMAN
θ value	5.99374e-20 (rank : 375)	NC score	0.941977 (rank : 186)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	832
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

MK01_MOUSE
θ value	7.82807e-20 (rank : 376)	NC score	0.907351 (rank : 426)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	828
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

PASK_HUMAN
θ value	7.82807e-20 (rank : 377)	NC score	0.937699 (rank : 220)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	815
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

CHK1_MOUSE
θ value	1.02238e-19 (rank : 378)	NC score	0.957496 (rank : 82)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	831
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

DAPK1_MOUSE
θ value	1.02238e-19 (rank : 379)	NC score	0.847588 (rank : 543)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1138	Shared Neighborhood Hits	835
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DMPK_HUMAN
θ value	1.02238e-19 (rank : 380)	NC score	0.897091 (rank : 472)
Query Neighborhood Hits	1311	Target Neighborhood Hits	944	Shared Neighborhood Hits	847
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

MK01_HUMAN
θ value	1.02238e-19 (rank : 381)	NC score	0.907279 (rank : 427)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	828
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MLTK_MOUSE
θ value	1.02238e-19 (rank : 382)	NC score	0.906666 (rank : 431)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	828
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

CDK7_MOUSE
θ value	1.33526e-19 (rank : 383)	NC score	0.928673 (rank : 293)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

DAPK2_HUMAN
θ value	1.33526e-19 (rank : 384)	NC score	0.942647 (rank : 179)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MK12_MOUSE
θ value	1.33526e-19 (rank : 385)	NC score	0.917540 (rank : 360)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	826
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MP2K3_HUMAN
θ value	1.33526e-19 (rank : 386)	NC score	0.937495 (rank : 223)
Query Neighborhood Hits	1311	Target Neighborhood Hits	825	Shared Neighborhood Hits	819
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

CTRO_HUMAN
θ value	1.74391e-19 (rank : 387)	NC score	0.827087 (rank : 592)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2092	Shared Neighborhood Hits	1056
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

GRK5_MOUSE
θ value	1.74391e-19 (rank : 388)	NC score	0.919745 (rank : 346)
Query Neighborhood Hits	1311	Target Neighborhood Hits	823	Shared Neighborhood Hits	812
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

IKKB_MOUSE
θ value	1.74391e-19 (rank : 389)	NC score	0.948757 (rank : 125)
Query Neighborhood Hits	1311	Target Neighborhood Hits	984	Shared Neighborhood Hits	889
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

CHK1_HUMAN
θ value	2.27762e-19 (rank : 390)	NC score	0.957270 (rank : 83)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	827
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MATK_MOUSE
θ value	2.27762e-19 (rank : 391)	NC score	0.832640 (rank : 574)
Query Neighborhood Hits	1311	Target Neighborhood Hits	952	Shared Neighborhood Hits	823
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

PFTK1_HUMAN
θ value	2.27762e-19 (rank : 392)	NC score	0.925266 (rank : 311)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	821
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

TESK1_HUMAN
θ value	2.27762e-19 (rank : 393)	NC score	0.917217 (rank : 363)
Query Neighborhood Hits	1311	Target Neighborhood Hits	864	Shared Neighborhood Hits	803
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

GRK5_HUMAN
θ value	2.97466e-19 (rank : 394)	NC score	0.919365 (rank : 348)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	812
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

JAK2_HUMAN
θ value	2.97466e-19 (rank : 395)	NC score	0.876676 (rank : 508)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	830
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

LIMK1_MOUSE
θ value	2.97466e-19 (rank : 396)	NC score	0.884048 (rank : 500)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1008	Shared Neighborhood Hits	822
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

PFTK1_MOUSE
θ value	2.97466e-19 (rank : 397)	NC score	0.925332 (rank : 310)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

ST38L_MOUSE
θ value	2.97466e-19 (rank : 398)	NC score	0.890269 (rank : 492)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	804
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

WEE1B_MOUSE
θ value	2.97466e-19 (rank : 399)	NC score	0.863787 (rank : 526)
Query Neighborhood Hits	1311	Target Neighborhood Hits	765	Shared Neighborhood Hits	733
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

CSK_MOUSE
θ value	3.88503e-19 (rank : 400)	NC score	0.840977 (rank : 560)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	832
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

JAK2_MOUSE
θ value	3.88503e-19 (rank : 401)	NC score	0.875772 (rank : 510)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	825
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

LATS2_HUMAN
θ value	3.88503e-19 (rank : 402)	NC score	0.879547 (rank : 506)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	826
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	3.88503e-19 (rank : 403)	NC score	0.879394 (rank : 507)
Query Neighborhood Hits	1311	Target Neighborhood Hits	879	Shared Neighborhood Hits	829
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

MAPK3_MOUSE
θ value	5.07402e-19 (rank : 404)	NC score	0.925451 (rank : 308)
Query Neighborhood Hits	1311	Target Neighborhood Hits	811	Shared Neighborhood Hits	806
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

NRK_HUMAN
θ value	5.07402e-19 (rank : 405)	NC score	0.930316 (rank : 283)
Query Neighborhood Hits	1311	Target Neighborhood Hits	931	Shared Neighborhood Hits	850
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

PASK_MOUSE
θ value	5.07402e-19 (rank : 406)	NC score	0.942298 (rank : 184)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	825
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

DMPK_MOUSE
θ value	6.62687e-19 (rank : 407)	NC score	0.897568 (rank : 470)
Query Neighborhood Hits	1311	Target Neighborhood Hits	908	Shared Neighborhood Hits	838
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

JAK1_HUMAN
θ value	6.62687e-19 (rank : 408)	NC score	0.859140 (rank : 528)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	831
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

TESK1_MOUSE
θ value	6.62687e-19 (rank : 409)	NC score	0.918501 (rank : 356)
Query Neighborhood Hits	1311	Target Neighborhood Hits	862	Shared Neighborhood Hits	802
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

M3K11_HUMAN
θ value	8.65492e-19 (rank : 410)	NC score	0.900783 (rank : 462)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1136	Shared Neighborhood Hits	849
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TLK2_HUMAN
θ value	8.65492e-19 (rank : 411)	NC score	0.917767 (rank : 359)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1044	Shared Neighborhood Hits	868
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	8.65492e-19 (rank : 412)	NC score	0.916518 (rank : 370)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1088	Shared Neighborhood Hits	888
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

LIMK1_HUMAN
θ value	1.13037e-18 (rank : 413)	NC score	0.884420 (rank : 498)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1005	Shared Neighborhood Hits	824
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

M3K9_HUMAN
θ value	1.13037e-18 (rank : 414)	NC score	0.903203 (rank : 450)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1123	Shared Neighborhood Hits	863
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	1.13037e-18 (rank : 415)	NC score	0.891031 (rank : 488)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1087	Shared Neighborhood Hits	856
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MAPK5_HUMAN
θ value	1.13037e-18 (rank : 416)	NC score	0.894124 (rank : 481)
Query Neighborhood Hits	1311	Target Neighborhood Hits	795	Shared Neighborhood Hits	785
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

MAPK5_MOUSE
θ value	1.13037e-18 (rank : 417)	NC score	0.896333 (rank : 476)
Query Neighborhood Hits	1311	Target Neighborhood Hits	799	Shared Neighborhood Hits	789
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

SRMS_MOUSE
θ value	1.13037e-18 (rank : 418)	NC score	0.826239 (rank : 593)
Query Neighborhood Hits	1311	Target Neighborhood Hits	964	Shared Neighborhood Hits	825
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

NRK_MOUSE
θ value	1.47631e-18 (rank : 419)	NC score	0.930430 (rank : 282)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	844
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

ITK_HUMAN
θ value	1.92812e-18 (rank : 420)	NC score	0.829692 (rank : 583)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1016	Shared Neighborhood Hits	824
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MATK_HUMAN
θ value	1.92812e-18 (rank : 421)	NC score	0.828342 (rank : 587)
Query Neighborhood Hits	1311	Target Neighborhood Hits	954	Shared Neighborhood Hits	823
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MRCKG_MOUSE
θ value	1.92812e-18 (rank : 422)	NC score	0.874276 (rank : 513)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1466	Shared Neighborhood Hits	971
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MAPK2_HUMAN
θ value	2.5182e-18 (rank : 423)	NC score	0.927971 (rank : 298)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	820
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

ARBK1_MOUSE
θ value	3.28887e-18 (rank : 424)	NC score	0.909825 (rank : 416)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	817
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

CCRK_HUMAN
θ value	3.28887e-18 (rank : 425)	NC score	0.918896 (rank : 353)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	827
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

MAPK2_MOUSE
θ value	3.28887e-18 (rank : 426)	NC score	0.926858 (rank : 303)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	817
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MP2K6_MOUSE
θ value	3.28887e-18 (rank : 427)	NC score	0.934759 (rank : 251)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	823
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

SRC_HUMAN
θ value	3.28887e-18 (rank : 428)	NC score	0.806350 (rank : 629)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1058	Shared Neighborhood Hits	825
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	3.28887e-18 (rank : 429)	NC score	0.807804 (rank : 627)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1033	Shared Neighborhood Hits	823
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

IRAK4_MOUSE
θ value	4.29542e-18 (rank : 430)	NC score	0.920784 (rank : 336)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	808
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITK_MOUSE
θ value	4.29542e-18 (rank : 431)	NC score	0.829900 (rank : 582)
Query Neighborhood Hits	1311	Target Neighborhood Hits	985	Shared Neighborhood Hits	825
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

WEE1B_HUMAN
θ value	4.29542e-18 (rank : 432)	NC score	0.866666 (rank : 524)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	745
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

FGFR3_HUMAN
θ value	5.60996e-18 (rank : 433)	NC score	0.788856 (rank : 659)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1042	Shared Neighborhood Hits	817
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

MK13_HUMAN
θ value	5.60996e-18 (rank : 434)	NC score	0.911792 (rank : 404)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	827
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

CAMKV_HUMAN
θ value	7.32683e-18 (rank : 435)	NC score	0.895732 (rank : 478)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1084	Shared Neighborhood Hits	806
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	7.32683e-18 (rank : 436)	NC score	0.901833 (rank : 452)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	779
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MK12_HUMAN
θ value	7.32683e-18 (rank : 437)	NC score	0.916402 (rank : 371)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	825
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MP2K6_HUMAN
θ value	7.32683e-18 (rank : 438)	NC score	0.934455 (rank : 253)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

BMX_HUMAN
θ value	9.56915e-18 (rank : 439)	NC score	0.832814 (rank : 571)
Query Neighborhood Hits	1311	Target Neighborhood Hits	942	Shared Neighborhood Hits	806
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

MAPK3_HUMAN
θ value	9.56915e-18 (rank : 440)	NC score	0.922005 (rank : 328)
Query Neighborhood Hits	1311	Target Neighborhood Hits	807	Shared Neighborhood Hits	796
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

FAK1_HUMAN
θ value	1.24977e-17 (rank : 441)	NC score	0.839248 (rank : 563)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	1.24977e-17 (rank : 442)	NC score	0.838884 (rank : 565)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

ARBK1_HUMAN
θ value	1.63225e-17 (rank : 443)	NC score	0.911393 (rank : 407)
Query Neighborhood Hits	1311	Target Neighborhood Hits	859	Shared Neighborhood Hits	817
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK2_HUMAN
θ value	1.63225e-17 (rank : 444)	NC score	0.909164 (rank : 419)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	817
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

JAK1_MOUSE
θ value	1.63225e-17 (rank : 445)	NC score	0.853732 (rank : 532)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	828
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

MK07_HUMAN
θ value	1.63225e-17 (rank : 446)	NC score	0.912418 (rank : 402)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1087	Shared Neighborhood Hits	850
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

MK07_MOUSE
θ value	1.63225e-17 (rank : 447)	NC score	0.912742 (rank : 398)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1054	Shared Neighborhood Hits	840
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

LATS1_HUMAN
θ value	2.13179e-17 (rank : 448)	NC score	0.884055 (rank : 499)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1057	Shared Neighborhood Hits	869
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LIMK2_HUMAN
θ value	2.13179e-17 (rank : 449)	NC score	0.889392 (rank : 494)
Query Neighborhood Hits	1311	Target Neighborhood Hits	986	Shared Neighborhood Hits	818
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MK06_MOUSE
θ value	2.13179e-17 (rank : 450)	NC score	0.895553 (rank : 479)
Query Neighborhood Hits	1311	Target Neighborhood Hits	818	Shared Neighborhood Hits	800
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MK15_HUMAN
θ value	2.13179e-17 (rank : 451)	NC score	0.918997 (rank : 349)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1038	Shared Neighborhood Hits	833
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

TEC_MOUSE
θ value	2.13179e-17 (rank : 452)	NC score	0.838221 (rank : 567)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1006	Shared Neighborhood Hits	825
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TESK2_MOUSE
θ value	2.13179e-17 (rank : 453)	NC score	0.917472 (rank : 361)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	814
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TXK_MOUSE
θ value	2.13179e-17 (rank : 454)	NC score	0.821301 (rank : 605)
Query Neighborhood Hits	1311	Target Neighborhood Hits	980	Shared Neighborhood Hits	808
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

FYN_HUMAN
θ value	2.7842e-17 (rank : 455)	NC score	0.811135 (rank : 618)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1078	Shared Neighborhood Hits	831
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

MK06_HUMAN
θ value	2.7842e-17 (rank : 456)	NC score	0.896059 (rank : 477)
Query Neighborhood Hits	1311	Target Neighborhood Hits	815	Shared Neighborhood Hits	799
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK09_MOUSE
θ value	2.7842e-17 (rank : 457)	NC score	0.901707 (rank : 453)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	829
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK13_MOUSE
θ value	2.7842e-17 (rank : 458)	NC score	0.912483 (rank : 401)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	826
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

TYK2_HUMAN
θ value	2.7842e-17 (rank : 459)	NC score	0.868604 (rank : 519)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	828
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

CDK3_MOUSE
θ value	3.63628e-17 (rank : 460)	NC score	0.932517 (rank : 265)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	825
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

MK09_HUMAN
θ value	3.63628e-17 (rank : 461)	NC score	0.904880 (rank : 443)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	831
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK10_HUMAN
θ value	3.63628e-17 (rank : 462)	NC score	0.900977 (rank : 459)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	825
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK10_MOUSE
θ value	3.63628e-17 (rank : 463)	NC score	0.900742 (rank : 463)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	825
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

LIMK2_MOUSE
θ value	4.74913e-17 (rank : 464)	NC score	0.885858 (rank : 496)
Query Neighborhood Hits	1311	Target Neighborhood Hits	998	Shared Neighborhood Hits	817
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

TLK1_HUMAN
θ value	4.74913e-17 (rank : 465)	NC score	0.915314 (rank : 383)
Query Neighborhood Hits	1311	Target Neighborhood Hits	967	Shared Neighborhood Hits	829
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	4.74913e-17 (rank : 466)	NC score	0.915072 (rank : 385)
Query Neighborhood Hits	1311	Target Neighborhood Hits	947	Shared Neighborhood Hits	829
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

AL2S7_HUMAN
θ value	6.20254e-17 (rank : 467)	NC score	0.918163 (rank : 357)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	821
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

GRK7_HUMAN
θ value	6.20254e-17 (rank : 468)	NC score	0.918987 (rank : 350)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	815
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

M3K10_HUMAN
θ value	6.20254e-17 (rank : 469)	NC score	0.903687 (rank : 447)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1071	Shared Neighborhood Hits	848
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

MK08_HUMAN
θ value	6.20254e-17 (rank : 470)	NC score	0.900961 (rank : 460)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	826
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	6.20254e-17 (rank : 471)	NC score	0.901635 (rank : 454)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	826
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

TYK2_MOUSE
θ value	6.20254e-17 (rank : 472)	NC score	0.863557 (rank : 527)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	826
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

FRK_HUMAN
θ value	8.10077e-17 (rank : 473)	NC score	0.827199 (rank : 591)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1058	Shared Neighborhood Hits	833
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

LATS1_MOUSE
θ value	8.10077e-17 (rank : 474)	NC score	0.881120 (rank : 503)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1027	Shared Neighborhood Hits	862
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

MK04_MOUSE
θ value	8.10077e-17 (rank : 475)	NC score	0.905540 (rank : 441)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	810
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

PTK6_MOUSE
θ value	8.10077e-17 (rank : 476)	NC score	0.846800 (rank : 544)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1026	Shared Neighborhood Hits	828
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TESK2_HUMAN
θ value	8.10077e-17 (rank : 477)	NC score	0.917182 (rank : 364)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	817
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

MK04_HUMAN
θ value	1.058e-16 (rank : 478)	NC score	0.907706 (rank : 425)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

CCRK_MOUSE
θ value	1.38178e-16 (rank : 479)	NC score	0.916108 (rank : 378)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	824
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

FGFR4_HUMAN
θ value	1.38178e-16 (rank : 480)	NC score	0.775794 (rank : 692)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1037	Shared Neighborhood Hits	804
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

TEC_HUMAN
θ value	1.38178e-16 (rank : 481)	NC score	0.832683 (rank : 573)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1006	Shared Neighborhood Hits	823
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TXK_HUMAN
θ value	1.38178e-16 (rank : 482)	NC score	0.832629 (rank : 575)
Query Neighborhood Hits	1311	Target Neighborhood Hits	971	Shared Neighborhood Hits	815
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

FGFR1_HUMAN
θ value	1.80466e-16 (rank : 483)	NC score	0.794015 (rank : 649)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1069	Shared Neighborhood Hits	820
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	1.80466e-16 (rank : 484)	NC score	0.794146 (rank : 648)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1068	Shared Neighborhood Hits	820
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FYN_MOUSE
θ value	1.80466e-16 (rank : 485)	NC score	0.805330 (rank : 630)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1073	Shared Neighborhood Hits	834
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

M3K14_MOUSE
θ value	1.80466e-16 (rank : 486)	NC score	0.928443 (rank : 295)
Query Neighborhood Hits	1311	Target Neighborhood Hits	889	Shared Neighborhood Hits	806
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MP2K1_HUMAN
θ value	1.80466e-16 (rank : 487)	NC score	0.946718 (rank : 146)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	822
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
θ value	1.80466e-16 (rank : 488)	NC score	0.946672 (rank : 147)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	822
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K2_MOUSE
θ value	1.80466e-16 (rank : 489)	NC score	0.946835 (rank : 142)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	824
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

SPEG_HUMAN
θ value	1.80466e-16 (rank : 490)	NC score	0.850801 (rank : 539)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1762	Shared Neighborhood Hits	875
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

CDK4_HUMAN
θ value	2.35696e-16 (rank : 491)	NC score	0.913822 (rank : 392)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	828
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

MK11_HUMAN
θ value	2.35696e-16 (rank : 492)	NC score	0.904371 (rank : 444)
Query Neighborhood Hits	1311	Target Neighborhood Hits	823	Shared Neighborhood Hits	822
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

NTRK2_MOUSE
θ value	2.35696e-16 (rank : 493)	NC score	0.796189 (rank : 646)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1088	Shared Neighborhood Hits	809
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

WEE1_HUMAN
θ value	2.35696e-16 (rank : 494)	NC score	0.881083 (rank : 504)
Query Neighborhood Hits	1311	Target Neighborhood Hits	777	Shared Neighborhood Hits	735
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

ABL1_HUMAN
θ value	3.07829e-16 (rank : 495)	NC score	0.827514 (rank : 589)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1220	Shared Neighborhood Hits	844
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FGFR3_MOUSE
θ value	3.07829e-16 (rank : 496)	NC score	0.784196 (rank : 668)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1059	Shared Neighborhood Hits	818
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

JAK3_HUMAN
θ value	3.07829e-16 (rank : 497)	NC score	0.867637 (rank : 522)
Query Neighborhood Hits	1311	Target Neighborhood Hits	827	Shared Neighborhood Hits	819
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

LCK_MOUSE
θ value	3.07829e-16 (rank : 498)	NC score	0.819831 (rank : 607)
Query Neighborhood Hits	1311	Target Neighborhood Hits	981	Shared Neighborhood Hits	826
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

NLK_HUMAN
θ value	3.07829e-16 (rank : 499)	NC score	0.913610 (rank : 394)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	829
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	3.07829e-16 (rank : 500)	NC score	0.913627 (rank : 393)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	829
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

BTK_HUMAN
θ value	4.02038e-16 (rank : 501)	NC score	0.823270 (rank : 601)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1026	Shared Neighborhood Hits	816
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	4.02038e-16 (rank : 502)	NC score	0.823217 (rank : 602)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1017	Shared Neighborhood Hits	818
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

EPHA4_HUMAN
θ value	4.02038e-16 (rank : 503)	NC score	0.774361 (rank : 696)
Query Neighborhood Hits	1311	Target Neighborhood Hits	975	Shared Neighborhood Hits	813
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	4.02038e-16 (rank : 504)	NC score	0.774099 (rank : 699)
Query Neighborhood Hits	1311	Target Neighborhood Hits	982	Shared Neighborhood Hits	814
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

MK15_MOUSE
θ value	4.02038e-16 (rank : 505)	NC score	0.914269 (rank : 390)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	816
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MP2K2_HUMAN
θ value	4.02038e-16 (rank : 506)	NC score	0.948041 (rank : 131)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

MP2K7_HUMAN
θ value	4.02038e-16 (rank : 507)	NC score	0.941657 (rank : 188)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	822
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

SPEG_MOUSE
θ value	4.02038e-16 (rank : 508)	NC score	0.844151 (rank : 551)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1959	Shared Neighborhood Hits	901
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

WEE1_MOUSE
θ value	4.02038e-16 (rank : 509)	NC score	0.892828 (rank : 486)
Query Neighborhood Hits	1311	Target Neighborhood Hits	794	Shared Neighborhood Hits	758
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

BMX_MOUSE
θ value	5.25075e-16 (rank : 510)	NC score	0.831466 (rank : 576)
Query Neighborhood Hits	1311	Target Neighborhood Hits	912	Shared Neighborhood Hits	795
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

EPHA2_HUMAN
θ value	5.25075e-16 (rank : 511)	NC score	0.780676 (rank : 676)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1021	Shared Neighborhood Hits	819
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

IRAK4_HUMAN
θ value	5.25075e-16 (rank : 512)	NC score	0.916164 (rank : 376)
Query Neighborhood Hits	1311	Target Neighborhood Hits	816	Shared Neighborhood Hits	807
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

LCK_HUMAN
θ value	5.25075e-16 (rank : 513)	NC score	0.814999 (rank : 612)
Query Neighborhood Hits	1311	Target Neighborhood Hits	987	Shared Neighborhood Hits	827
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

FGFR2_HUMAN
θ value	6.85773e-16 (rank : 514)	NC score	0.797720 (rank : 643)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1062	Shared Neighborhood Hits	819
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	6.85773e-16 (rank : 515)	NC score	0.800116 (rank : 635)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1062	Shared Neighborhood Hits	819
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

JAK3_MOUSE
θ value	6.85773e-16 (rank : 516)	NC score	0.872224 (rank : 514)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	812
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

MP2K4_HUMAN
θ value	6.85773e-16 (rank : 517)	NC score	0.938251 (rank : 216)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	826
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	6.85773e-16 (rank : 518)	NC score	0.938304 (rank : 214)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	826
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

TOPK_MOUSE
θ value	6.85773e-16 (rank : 519)	NC score	0.758321 (rank : 725)
Query Neighborhood Hits	1311	Target Neighborhood Hits	618	Shared Neighborhood Hits	608
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

ABL1_MOUSE
θ value	8.95645e-16 (rank : 520)	NC score	0.827762 (rank : 588)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1178	Shared Neighborhood Hits	839
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CDK4_MOUSE
θ value	8.95645e-16 (rank : 521)	NC score	0.914852 (rank : 387)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	830
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

EPHA3_HUMAN
θ value	8.95645e-16 (rank : 522)	NC score	0.786616 (rank : 664)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1005	Shared Neighborhood Hits	816
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

ABL2_HUMAN
θ value	1.16975e-15 (rank : 523)	NC score	0.825593 (rank : 596)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1045	Shared Neighborhood Hits	825
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

NTRK2_HUMAN
θ value	1.16975e-15 (rank : 524)	NC score	0.796293 (rank : 645)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1081	Shared Neighborhood Hits	809
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

PTK6_HUMAN
θ value	1.16975e-15 (rank : 525)	NC score	0.849754 (rank : 542)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1020	Shared Neighborhood Hits	827
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

TNI3K_MOUSE
θ value	1.16975e-15 (rank : 526)	NC score	0.786313 (rank : 665)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1079	Shared Neighborhood Hits	792
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TRIO_HUMAN
θ value	1.16975e-15 (rank : 527)	NC score	0.844250 (rank : 549)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1580	Shared Neighborhood Hits	928
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

CDK8_HUMAN
θ value	1.52774e-15 (rank : 528)	NC score	0.892722 (rank : 487)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	817
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

MKNK1_MOUSE
θ value	1.52774e-15 (rank : 529)	NC score	0.910799 (rank : 413)
Query Neighborhood Hits	1311	Target Neighborhood Hits	811	Shared Neighborhood Hits	800
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

PTK7_HUMAN
θ value	1.52774e-15 (rank : 530)	NC score	0.727461 (rank : 766)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1103	Shared Neighborhood Hits	785
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

TNI3K_HUMAN
θ value	1.52774e-15 (rank : 531)	NC score	0.778961 (rank : 683)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1084	Shared Neighborhood Hits	797
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CD2L6_HUMAN
θ value	1.99529e-15 (rank : 532)	NC score	0.896782 (rank : 474)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	816
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	1.99529e-15 (rank : 533)	NC score	0.896824 (rank : 473)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	819
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

E2AK3_MOUSE
θ value	1.99529e-15 (rank : 534)	NC score	0.927742 (rank : 302)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	832
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

LYN_MOUSE
θ value	1.99529e-15 (rank : 535)	NC score	0.826142 (rank : 594)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1023	Shared Neighborhood Hits	838
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

EPHA3_MOUSE
θ value	2.60593e-15 (rank : 536)	NC score	0.779821 (rank : 677)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	820
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

FGFR4_MOUSE
θ value	2.60593e-15 (rank : 537)	NC score	0.754617 (rank : 734)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1026	Shared Neighborhood Hits	792
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

LYN_HUMAN
θ value	2.60593e-15 (rank : 538)	NC score	0.825533 (rank : 598)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1022	Shared Neighborhood Hits	836
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MASTL_MOUSE
θ value	2.60593e-15 (rank : 539)	NC score	0.925213 (rank : 312)
Query Neighborhood Hits	1311	Target Neighborhood Hits	862	Shared Neighborhood Hits	835
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

RIPK1_HUMAN
θ value	2.60593e-15 (rank : 540)	NC score	0.912012 (rank : 403)
Query Neighborhood Hits	1311	Target Neighborhood Hits	891	Shared Neighborhood Hits	841
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

SRMS_HUMAN
θ value	2.60593e-15 (rank : 541)	NC score	0.819407 (rank : 608)
Query Neighborhood Hits	1311	Target Neighborhood Hits	946	Shared Neighborhood Hits	825
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

EPHA2_MOUSE
θ value	3.40345e-15 (rank : 542)	NC score	0.779458 (rank : 679)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1020	Shared Neighborhood Hits	814
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA5_HUMAN
θ value	3.40345e-15 (rank : 543)	NC score	0.781710 (rank : 674)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	814
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

M3K8_MOUSE
θ value	3.40345e-15 (rank : 544)	NC score	0.930497 (rank : 280)
Query Neighborhood Hits	1311	Target Neighborhood Hits	815	Shared Neighborhood Hits	802
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MP2K5_MOUSE
θ value	3.40345e-15 (rank : 545)	NC score	0.945935 (rank : 153)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

RIPK1_MOUSE
θ value	3.40345e-15 (rank : 546)	NC score	0.906510 (rank : 435)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	839
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

MASTL_HUMAN
θ value	4.44505e-15 (rank : 547)	NC score	0.924886 (rank : 314)
Query Neighborhood Hits	1311	Target Neighborhood Hits	894	Shared Neighborhood Hits	841
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

SBK1_MOUSE
θ value	4.44505e-15 (rank : 548)	NC score	0.941177 (rank : 192)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	804
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TIE2_HUMAN
θ value	4.44505e-15 (rank : 549)	NC score	0.790419 (rank : 654)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1192	Shared Neighborhood Hits	812
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

EPHA7_HUMAN
θ value	5.8054e-15 (rank : 550)	NC score	0.781311 (rank : 675)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1053	Shared Neighborhood Hits	820
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	5.8054e-15 (rank : 551)	NC score	0.782423 (rank : 672)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1025	Shared Neighborhood Hits	821
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

INSRR_HUMAN
θ value	5.8054e-15 (rank : 552)	NC score	0.755400 (rank : 732)
Query Neighborhood Hits	1311	Target Neighborhood Hits	950	Shared Neighborhood Hits	779
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	5.8054e-15 (rank : 553)	NC score	0.758009 (rank : 726)
Query Neighborhood Hits	1311	Target Neighborhood Hits	961	Shared Neighborhood Hits	779
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ROS_HUMAN
θ value	5.8054e-15 (rank : 554)	NC score	0.774220 (rank : 698)
Query Neighborhood Hits	1311	Target Neighborhood Hits	907	Shared Neighborhood Hits	767
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

SBK1_HUMAN
θ value	5.8054e-15 (rank : 555)	NC score	0.938876 (rank : 210)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	806
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TIE2_MOUSE
θ value	5.8054e-15 (rank : 556)	NC score	0.789319 (rank : 657)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1204	Shared Neighborhood Hits	812
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TOPK_HUMAN
θ value	5.8054e-15 (rank : 557)	NC score	0.749145 (rank : 740)
Query Neighborhood Hits	1311	Target Neighborhood Hits	605	Shared Neighborhood Hits	597
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

EPHA5_MOUSE
θ value	7.58209e-15 (rank : 558)	NC score	0.802360 (rank : 631)
Query Neighborhood Hits	1311	Target Neighborhood Hits	950	Shared Neighborhood Hits	814
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

INSR_MOUSE
θ value	7.58209e-15 (rank : 559)	NC score	0.774360 (rank : 697)
Query Neighborhood Hits	1311	Target Neighborhood Hits	968	Shared Neighborhood Hits	798
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

HCK_HUMAN
θ value	9.90251e-15 (rank : 560)	NC score	0.811217 (rank : 617)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1035	Shared Neighborhood Hits	831
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

IGF1R_MOUSE
θ value	9.90251e-15 (rank : 561)	NC score	0.760309 (rank : 722)
Query Neighborhood Hits	1311	Target Neighborhood Hits	973	Shared Neighborhood Hits	788
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

MK11_MOUSE
θ value	1.29331e-14 (rank : 562)	NC score	0.908492 (rank : 421)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	829
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

PDK1L_HUMAN
θ value	1.29331e-14 (rank : 563)	NC score	0.943805 (rank : 170)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	814
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	1.29331e-14 (rank : 564)	NC score	0.943677 (rank : 173)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	815
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

TTK_HUMAN
θ value	1.29331e-14 (rank : 565)	NC score	0.922877 (rank : 322)
Query Neighborhood Hits	1311	Target Neighborhood Hits	816	Shared Neighborhood Hits	781
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

E2AK4_HUMAN
θ value	1.68911e-14 (rank : 566)	NC score	0.914627 (rank : 388)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1012	Shared Neighborhood Hits	869
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

MKNK2_HUMAN
θ value	1.68911e-14 (rank : 567)	NC score	0.915947 (rank : 381)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	813
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MKNK2_MOUSE
θ value	1.68911e-14 (rank : 568)	NC score	0.914123 (rank : 391)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	812
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

E2AK3_HUMAN
θ value	2.20605e-14 (rank : 569)	NC score	0.927957 (rank : 299)
Query Neighborhood Hits	1311	Target Neighborhood Hits	859	Shared Neighborhood Hits	828
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

M3K8_HUMAN
θ value	2.20605e-14 (rank : 570)	NC score	0.930704 (rank : 278)
Query Neighborhood Hits	1311	Target Neighborhood Hits	807	Shared Neighborhood Hits	800
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MP2K5_HUMAN
θ value	2.20605e-14 (rank : 571)	NC score	0.940978 (rank : 194)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	827
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

FGR_HUMAN
θ value	2.88119e-14 (rank : 572)	NC score	0.793187 (rank : 651)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1067	Shared Neighborhood Hits	830
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

HCK_MOUSE
θ value	2.88119e-14 (rank : 573)	NC score	0.807810 (rank : 626)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1029	Shared Neighborhood Hits	828
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

M3K14_HUMAN
θ value	2.88119e-14 (rank : 574)	NC score	0.934098 (rank : 255)
Query Neighborhood Hits	1311	Target Neighborhood Hits	887	Shared Neighborhood Hits	812
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

YES_HUMAN
θ value	2.88119e-14 (rank : 575)	NC score	0.800726 (rank : 633)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1059	Shared Neighborhood Hits	823
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CLK4_HUMAN
θ value	3.76295e-14 (rank : 576)	NC score	0.822723 (rank : 603)
Query Neighborhood Hits	1311	Target Neighborhood Hits	759	Shared Neighborhood Hits	749
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

IGF1R_HUMAN
θ value	3.76295e-14 (rank : 577)	NC score	0.758466 (rank : 724)
Query Neighborhood Hits	1311	Target Neighborhood Hits	977	Shared Neighborhood Hits	788
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

YES_MOUSE
θ value	3.76295e-14 (rank : 578)	NC score	0.800212 (rank : 634)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1052	Shared Neighborhood Hits	822
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

CLK4_MOUSE
θ value	4.91457e-14 (rank : 579)	NC score	0.821086 (rank : 606)
Query Neighborhood Hits	1311	Target Neighborhood Hits	759	Shared Neighborhood Hits	748
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

E2AK4_MOUSE
θ value	4.91457e-14 (rank : 580)	NC score	0.909801 (rank : 417)
Query Neighborhood Hits	1311	Target Neighborhood Hits	984	Shared Neighborhood Hits	864
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

FER_HUMAN
θ value	4.91457e-14 (rank : 581)	NC score	0.836748 (rank : 569)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1278	Shared Neighborhood Hits	922
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CI096_HUMAN
θ value	6.41864e-14 (rank : 582)	NC score	0.916974 (rank : 367)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	802
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

FES_MOUSE
θ value	6.41864e-14 (rank : 583)	NC score	0.851703 (rank : 536)
Query Neighborhood Hits	1311	Target Neighborhood Hits	980	Shared Neighborhood Hits	840
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

INSR_HUMAN
θ value	6.41864e-14 (rank : 584)	NC score	0.776202 (rank : 691)
Query Neighborhood Hits	1311	Target Neighborhood Hits	963	Shared Neighborhood Hits	805
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

FES_HUMAN
θ value	8.38298e-14 (rank : 585)	NC score	0.851136 (rank : 538)
Query Neighborhood Hits	1311	Target Neighborhood Hits	978	Shared Neighborhood Hits	827
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

CLK1_HUMAN
θ value	1.09485e-13 (rank : 586)	NC score	0.824483 (rank : 600)
Query Neighborhood Hits	1311	Target Neighborhood Hits	756	Shared Neighborhood Hits	742
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

FAK2_MOUSE
θ value	1.09485e-13 (rank : 587)	NC score	0.827306 (rank : 590)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	807
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

BLK_HUMAN
θ value	1.42992e-13 (rank : 588)	NC score	0.813693 (rank : 614)
Query Neighborhood Hits	1311	Target Neighborhood Hits	994	Shared Neighborhood Hits	828
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PIM1_MOUSE
θ value	1.86753e-13 (rank : 589)	NC score	0.907069 (rank : 429)
Query Neighborhood Hits	1311	Target Neighborhood Hits	787	Shared Neighborhood Hits	780
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PIM2_MOUSE
θ value	1.86753e-13 (rank : 590)	NC score	0.916250 (rank : 372)
Query Neighborhood Hits	1311	Target Neighborhood Hits	809	Shared Neighborhood Hits	799
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

IKKE_HUMAN
θ value	2.43908e-13 (rank : 591)	NC score	0.935872 (rank : 239)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	815
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

TIE1_MOUSE
θ value	2.43908e-13 (rank : 592)	NC score	0.770428 (rank : 706)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1266	Shared Neighborhood Hits	813
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TTK_MOUSE
θ value	2.43908e-13 (rank : 593)	NC score	0.917405 (rank : 362)
Query Neighborhood Hits	1311	Target Neighborhood Hits	803	Shared Neighborhood Hits	763
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

EPHA6_HUMAN
θ value	3.18553e-13 (rank : 594)	NC score	0.728209 (rank : 764)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	799
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	3.18553e-13 (rank : 595)	NC score	0.733264 (rank : 757)
Query Neighborhood Hits	1311	Target Neighborhood Hits	946	Shared Neighborhood Hits	803
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

FAK2_HUMAN
θ value	3.18553e-13 (rank : 596)	NC score	0.822493 (rank : 604)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	804
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

MERTK_MOUSE
θ value	3.18553e-13 (rank : 597)	NC score	0.754420 (rank : 735)
Query Neighborhood Hits	1311	Target Neighborhood Hits	974	Shared Neighborhood Hits	765
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

EPHA8_HUMAN
θ value	5.43371e-13 (rank : 598)	NC score	0.770979 (rank : 704)
Query Neighborhood Hits	1311	Target Neighborhood Hits	956	Shared Neighborhood Hits	809
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

BLK_MOUSE
θ value	7.09661e-13 (rank : 599)	NC score	0.810218 (rank : 621)
Query Neighborhood Hits	1311	Target Neighborhood Hits	992	Shared Neighborhood Hits	827
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

EPHB2_HUMAN
θ value	7.09661e-13 (rank : 600)	NC score	0.774940 (rank : 695)
Query Neighborhood Hits	1311	Target Neighborhood Hits	983	Shared Neighborhood Hits	811
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	7.09661e-13 (rank : 601)	NC score	0.775108 (rank : 694)
Query Neighborhood Hits	1311	Target Neighborhood Hits	982	Shared Neighborhood Hits	811
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

GSK3B_HUMAN
θ value	7.09661e-13 (rank : 602)	NC score	0.906615 (rank : 432)
Query Neighborhood Hits	1311	Target Neighborhood Hits	801	Shared Neighborhood Hits	797
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	7.09661e-13 (rank : 603)	NC score	0.906594 (rank : 433)
Query Neighborhood Hits	1311	Target Neighborhood Hits	800	Shared Neighborhood Hits	796
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

MERTK_HUMAN
θ value	7.09661e-13 (rank : 604)	NC score	0.747856 (rank : 742)
Query Neighborhood Hits	1311	Target Neighborhood Hits	988	Shared Neighborhood Hits	771
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_MOUSE
θ value	7.09661e-13 (rank : 605)	NC score	0.790503 (rank : 653)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	798
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

NTRK3_HUMAN
θ value	7.09661e-13 (rank : 606)	NC score	0.764524 (rank : 714)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1115	Shared Neighborhood Hits	796
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

STK35_HUMAN
θ value	7.09661e-13 (rank : 607)	NC score	0.939194 (rank : 207)
Query Neighborhood Hits	1311	Target Neighborhood Hits	825	Shared Neighborhood Hits	815
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

TIE1_HUMAN
θ value	7.09661e-13 (rank : 608)	NC score	0.768743 (rank : 707)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1241	Shared Neighborhood Hits	812
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

EPHA8_MOUSE
θ value	9.26847e-13 (rank : 609)	NC score	0.765759 (rank : 711)
Query Neighborhood Hits	1311	Target Neighborhood Hits	969	Shared Neighborhood Hits	806
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

PIM1_HUMAN
θ value	9.26847e-13 (rank : 610)	NC score	0.908656 (rank : 420)
Query Neighborhood Hits	1311	Target Neighborhood Hits	797	Shared Neighborhood Hits	792
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

ERBB4_HUMAN
θ value	1.2105e-12 (rank : 611)	NC score	0.798844 (rank : 639)
Query Neighborhood Hits	1311	Target Neighborhood Hits	910	Shared Neighborhood Hits	800
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

TYRO3_HUMAN
θ value	1.2105e-12 (rank : 612)	NC score	0.757106 (rank : 728)
Query Neighborhood Hits	1311	Target Neighborhood Hits	995	Shared Neighborhood Hits	775
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

UFO_MOUSE
θ value	1.2105e-12 (rank : 613)	NC score	0.765497 (rank : 712)
Query Neighborhood Hits	1311	Target Neighborhood Hits	988	Shared Neighborhood Hits	764
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

FGR_MOUSE
θ value	1.58096e-12 (rank : 614)	NC score	0.789361 (rank : 656)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1069	Shared Neighborhood Hits	828
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

NTRK1_HUMAN
θ value	1.58096e-12 (rank : 615)	NC score	0.772771 (rank : 700)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1023	Shared Neighborhood Hits	789
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

UFO_HUMAN
θ value	1.58096e-12 (rank : 616)	NC score	0.761169 (rank : 719)
Query Neighborhood Hits	1311	Target Neighborhood Hits	981	Shared Neighborhood Hits	765
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

EPHB4_HUMAN
θ value	2.0648e-12 (rank : 617)	NC score	0.776529 (rank : 689)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1056	Shared Neighborhood Hits	806
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	2.0648e-12 (rank : 618)	NC score	0.779475 (rank : 678)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1013	Shared Neighborhood Hits	807
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

IRAK1_HUMAN
θ value	2.0648e-12 (rank : 619)	NC score	0.840663 (rank : 561)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	760
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

MET_HUMAN
θ value	2.0648e-12 (rank : 620)	NC score	0.787950 (rank : 661)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	796
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

PIM2_HUMAN
θ value	2.0648e-12 (rank : 621)	NC score	0.917161 (rank : 365)
Query Neighborhood Hits	1311	Target Neighborhood Hits	808	Shared Neighborhood Hits	805
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

RET_HUMAN
θ value	2.0648e-12 (rank : 622)	NC score	0.807937 (rank : 625)
Query Neighborhood Hits	1311	Target Neighborhood Hits	873	Shared Neighborhood Hits	806
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

DDR1_MOUSE
θ value	2.69671e-12 (rank : 623)	NC score	0.752112 (rank : 738)
Query Neighborhood Hits	1311	Target Neighborhood Hits	818	Shared Neighborhood Hits	768
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

CLK2_HUMAN
θ value	3.52202e-12 (rank : 624)	NC score	0.813449 (rank : 615)
Query Neighborhood Hits	1311	Target Neighborhood Hits	752	Shared Neighborhood Hits	739
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

EPHB1_HUMAN
θ value	3.52202e-12 (rank : 625)	NC score	0.790251 (rank : 655)
Query Neighborhood Hits	1311	Target Neighborhood Hits	988	Shared Neighborhood Hits	811
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

RON_MOUSE
θ value	3.52202e-12 (rank : 626)	NC score	0.785283 (rank : 666)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	797
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

CLK1_MOUSE
θ value	6.00763e-12 (rank : 627)	NC score	0.825530 (rank : 599)
Query Neighborhood Hits	1311	Target Neighborhood Hits	760	Shared Neighborhood Hits	749
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

KSR2_HUMAN
θ value	6.00763e-12 (rank : 628)	NC score	0.884950 (rank : 497)
Query Neighborhood Hits	1311	Target Neighborhood Hits	920	Shared Neighborhood Hits	811
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

RET_MOUSE
θ value	6.00763e-12 (rank : 629)	NC score	0.807286 (rank : 628)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	803
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

CLK3_HUMAN
θ value	7.84624e-12 (rank : 630)	NC score	0.793676 (rank : 650)
Query Neighborhood Hits	1311	Target Neighborhood Hits	748	Shared Neighborhood Hits	731
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	7.84624e-12 (rank : 631)	NC score	0.793068 (rank : 652)
Query Neighborhood Hits	1311	Target Neighborhood Hits	761	Shared Neighborhood Hits	732
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

TNK1_HUMAN
θ value	7.84624e-12 (rank : 632)	NC score	0.801994 (rank : 632)
Query Neighborhood Hits	1311	Target Neighborhood Hits	815	Shared Neighborhood Hits	773
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TYRO3_MOUSE
θ value	7.84624e-12 (rank : 633)	NC score	0.756336 (rank : 730)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1007	Shared Neighborhood Hits	774
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

DDR1_HUMAN
θ value	1.02475e-11 (rank : 634)	NC score	0.749236 (rank : 739)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	769
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

IKKE_MOUSE
θ value	1.02475e-11 (rank : 635)	NC score	0.933708 (rank : 257)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	821
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

IRAK1_MOUSE
θ value	1.02475e-11 (rank : 636)	NC score	0.838702 (rank : 566)
Query Neighborhood Hits	1311	Target Neighborhood Hits	784	Shared Neighborhood Hits	747
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

MUSK_HUMAN
θ value	1.02475e-11 (rank : 637)	NC score	0.718707 (rank : 778)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1074	Shared Neighborhood Hits	786
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

AATK_HUMAN
θ value	1.33837e-11 (rank : 638)	NC score	0.782372 (rank : 673)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1243	Shared Neighborhood Hits	790
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

F5006_MOUSE
θ value	1.33837e-11 (rank : 639)	NC score	0.907273 (rank : 428)
Query Neighborhood Hits	1311	Target Neighborhood Hits	793	Shared Neighborhood Hits	790
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

HIPK3_HUMAN
θ value	1.33837e-11 (rank : 640)	NC score	0.849973 (rank : 541)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	801
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	1.33837e-11 (rank : 641)	NC score	0.851773 (rank : 535)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	792
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

LRRK2_HUMAN
θ value	1.33837e-11 (rank : 642)	NC score	0.798251 (rank : 642)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1382	Shared Neighborhood Hits	833
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

TBK1_MOUSE
θ value	1.33837e-11 (rank : 643)	NC score	0.927806 (rank : 301)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

DYRK2_HUMAN
θ value	1.74796e-11 (rank : 644)	NC score	0.866472 (rank : 525)
Query Neighborhood Hits	1311	Target Neighborhood Hits	799	Shared Neighborhood Hits	787
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

EPHB3_HUMAN
θ value	1.74796e-11 (rank : 645)	NC score	0.764242 (rank : 715)
Query Neighborhood Hits	1311	Target Neighborhood Hits	996	Shared Neighborhood Hits	812
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

DYRK3_HUMAN
θ value	2.28291e-11 (rank : 646)	NC score	0.868823 (rank : 517)
Query Neighborhood Hits	1311	Target Neighborhood Hits	798	Shared Neighborhood Hits	788
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

ERBB3_HUMAN
θ value	2.28291e-11 (rank : 647)	NC score	0.760391 (rank : 721)
Query Neighborhood Hits	1311	Target Neighborhood Hits	918	Shared Neighborhood Hits	775
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

GSK3A_HUMAN
θ value	2.28291e-11 (rank : 648)	NC score	0.909301 (rank : 418)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	799
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

MLKL_HUMAN
θ value	2.28291e-11 (rank : 649)	NC score	0.698163 (rank : 793)
Query Neighborhood Hits	1311	Target Neighborhood Hits	600	Shared Neighborhood Hits	588
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

TBK1_HUMAN
θ value	2.28291e-11 (rank : 650)	NC score	0.927921 (rank : 300)
Query Neighborhood Hits	1311	Target Neighborhood Hits	861	Shared Neighborhood Hits	818
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TRIB1_MOUSE
θ value	2.28291e-11 (rank : 651)	NC score	0.778347 (rank : 684)
Query Neighborhood Hits	1311	Target Neighborhood Hits	593	Shared Neighborhood Hits	587
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

AATK_MOUSE
θ value	2.98157e-11 (rank : 652)	NC score	0.776241 (rank : 690)
Query Neighborhood Hits	1311	Target Neighborhood Hits	942	Shared Neighborhood Hits	768
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

CLK2_MOUSE
θ value	2.98157e-11 (rank : 653)	NC score	0.798464 (rank : 640)
Query Neighborhood Hits	1311	Target Neighborhood Hits	743	Shared Neighborhood Hits	733
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

F5006_HUMAN
θ value	2.98157e-11 (rank : 654)	NC score	0.897314 (rank : 471)
Query Neighborhood Hits	1311	Target Neighborhood Hits	794	Shared Neighborhood Hits	784
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

RIPK4_HUMAN
θ value	2.98157e-11 (rank : 655)	NC score	0.698691 (rank : 792)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1094	Shared Neighborhood Hits	801
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

RON_HUMAN
θ value	2.98157e-11 (rank : 656)	NC score	0.795508 (rank : 647)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	804
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

TRIB1_HUMAN
θ value	2.98157e-11 (rank : 657)	NC score	0.779406 (rank : 680)
Query Neighborhood Hits	1311	Target Neighborhood Hits	598	Shared Neighborhood Hits	585
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

VGFR1_MOUSE
θ value	2.98157e-11 (rank : 658)	NC score	0.728096 (rank : 765)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1118	Shared Neighborhood Hits	809
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

ACK1_HUMAN
θ value	3.89403e-11 (rank : 659)	NC score	0.799992 (rank : 636)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1140	Shared Neighborhood Hits	828
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

DUET_HUMAN
θ value	3.89403e-11 (rank : 660)	NC score	0.839289 (rank : 562)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1220	Shared Neighborhood Hits	814
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

EGFR_MOUSE
θ value	3.89403e-11 (rank : 661)	NC score	0.798932 (rank : 638)
Query Neighborhood Hits	1311	Target Neighborhood Hits	927	Shared Neighborhood Hits	811
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

ACK1_MOUSE
θ value	5.08577e-11 (rank : 662)	NC score	0.799313 (rank : 637)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1080	Shared Neighborhood Hits	823
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

EGFR_HUMAN
θ value	5.08577e-11 (rank : 663)	NC score	0.798406 (rank : 641)
Query Neighborhood Hits	1311	Target Neighborhood Hits	939	Shared Neighborhood Hits	809
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

ERBB2_MOUSE
θ value	5.08577e-11 (rank : 664)	NC score	0.788359 (rank : 660)
Query Neighborhood Hits	1311	Target Neighborhood Hits	918	Shared Neighborhood Hits	810
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

MKNK1_HUMAN
θ value	5.08577e-11 (rank : 665)	NC score	0.843485 (rank : 554)
Query Neighborhood Hits	1311	Target Neighborhood Hits	701	Shared Neighborhood Hits	691
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

STYK1_HUMAN
θ value	5.08577e-11 (rank : 666)	NC score	0.789202 (rank : 658)
Query Neighborhood Hits	1311	Target Neighborhood Hits	786	Shared Neighborhood Hits	773
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

EPHB3_MOUSE
θ value	6.64225e-11 (rank : 667)	NC score	0.762977 (rank : 717)
Query Neighborhood Hits	1311	Target Neighborhood Hits	996	Shared Neighborhood Hits	813
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

HIPK4_HUMAN
θ value	6.64225e-11 (rank : 668)	NC score	0.883037 (rank : 501)
Query Neighborhood Hits	1311	Target Neighborhood Hits	799	Shared Neighborhood Hits	787
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

VGFR1_HUMAN
θ value	6.64225e-11 (rank : 669)	NC score	0.721334 (rank : 776)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1109	Shared Neighborhood Hits	805
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

DYRK4_HUMAN
θ value	8.67504e-11 (rank : 670)	NC score	0.838965 (rank : 564)
Query Neighborhood Hits	1311	Target Neighborhood Hits	750	Shared Neighborhood Hits	743
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

ERBB2_HUMAN
θ value	8.67504e-11 (rank : 671)	NC score	0.784747 (rank : 667)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1073	Shared Neighborhood Hits	815
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

PIM3_MOUSE
θ value	8.67504e-11 (rank : 672)	NC score	0.903010 (rank : 451)
Query Neighborhood Hits	1311	Target Neighborhood Hits	783	Shared Neighborhood Hits	780
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

LRRK2_MOUSE
θ value	1.133e-10 (rank : 673)	NC score	0.779028 (rank : 682)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1359	Shared Neighborhood Hits	823
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

STK40_HUMAN
θ value	1.47974e-10 (rank : 674)	NC score	0.868715 (rank : 518)
Query Neighborhood Hits	1311	Target Neighborhood Hits	751	Shared Neighborhood Hits	743
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	1.47974e-10 (rank : 675)	NC score	0.868405 (rank : 520)
Query Neighborhood Hits	1311	Target Neighborhood Hits	751	Shared Neighborhood Hits	743
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

STYK1_MOUSE
θ value	1.47974e-10 (rank : 676)	NC score	0.775281 (rank : 693)
Query Neighborhood Hits	1311	Target Neighborhood Hits	779	Shared Neighborhood Hits	767
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

ALK_HUMAN
θ value	1.9326e-10 (rank : 677)	NC score	0.743162 (rank : 744)
Query Neighborhood Hits	1311	Target Neighborhood Hits	795	Shared Neighborhood Hits	742
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ERBB3_MOUSE
θ value	1.9326e-10 (rank : 678)	NC score	0.763932 (rank : 716)
Query Neighborhood Hits	1311	Target Neighborhood Hits	898	Shared Neighborhood Hits	776
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

MUSK_MOUSE
θ value	1.9326e-10 (rank : 679)	NC score	0.713596 (rank : 782)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1057	Shared Neighborhood Hits	783
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

PIM3_HUMAN
θ value	1.9326e-10 (rank : 680)	NC score	0.906516 (rank : 434)
Query Neighborhood Hits	1311	Target Neighborhood Hits	789	Shared Neighborhood Hits	786
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

EPHA1_HUMAN
θ value	2.52405e-10 (rank : 681)	NC score	0.776965 (rank : 688)
Query Neighborhood Hits	1311	Target Neighborhood Hits	997	Shared Neighborhood Hits	802
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

HIPK2_HUMAN
θ value	2.52405e-10 (rank : 682)	NC score	0.843279 (rank : 555)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	783
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	2.52405e-10 (rank : 683)	NC score	0.843036 (rank : 556)
Query Neighborhood Hits	1311	Target Neighborhood Hits	871	Shared Neighborhood Hits	787
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

RIPK5_HUMAN
θ value	2.52405e-10 (rank : 684)	NC score	0.910889 (rank : 411)
Query Neighborhood Hits	1311	Target Neighborhood Hits	864	Shared Neighborhood Hits	841
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	2.52405e-10 (rank : 685)	NC score	0.910472 (rank : 414)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	843
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

TGFR1_HUMAN
θ value	2.52405e-10 (rank : 686)	NC score	0.757356 (rank : 727)
Query Neighborhood Hits	1311	Target Neighborhood Hits	755	Shared Neighborhood Hits	749
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	2.52405e-10 (rank : 687)	NC score	0.756982 (rank : 729)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	749
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

ERN1_HUMAN
θ value	3.29651e-10 (rank : 688)	NC score	0.903354 (rank : 449)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	814
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

ERN2_HUMAN
θ value	3.29651e-10 (rank : 689)	NC score	0.894989 (rank : 480)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

TNK1_MOUSE
θ value	3.29651e-10 (rank : 690)	NC score	0.808602 (rank : 623)
Query Neighborhood Hits	1311	Target Neighborhood Hits	806	Shared Neighborhood Hits	774
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

MLKL_MOUSE
θ value	4.30538e-10 (rank : 691)	NC score	0.783978 (rank : 669)
Query Neighborhood Hits	1311	Target Neighborhood Hits	707	Shared Neighborhood Hits	697
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ANKK1_HUMAN
θ value	5.62301e-10 (rank : 692)	NC score	0.693517 (rank : 798)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1075	Shared Neighborhood Hits	791
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	5.62301e-10 (rank : 693)	NC score	0.707204 (rank : 789)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1072	Shared Neighborhood Hits	795
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ZAP70_MOUSE
θ value	5.62301e-10 (rank : 694)	NC score	0.828624 (rank : 586)
Query Neighborhood Hits	1311	Target Neighborhood Hits	905	Shared Neighborhood Hits	819
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

EPHA1_MOUSE
θ value	7.34386e-10 (rank : 695)	NC score	0.767183 (rank : 710)
Query Neighborhood Hits	1311	Target Neighborhood Hits	958	Shared Neighborhood Hits	791
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

KIT_HUMAN
θ value	7.34386e-10 (rank : 696)	NC score	0.731623 (rank : 762)
Query Neighborhood Hits	1311	Target Neighborhood Hits	953	Shared Neighborhood Hits	795
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

AL2S2_HUMAN
θ value	9.59137e-10 (rank : 697)	NC score	0.857350 (rank : 529)
Query Neighborhood Hits	1311	Target Neighborhood Hits	727	Shared Neighborhood Hits	715
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

CSF1R_MOUSE
θ value	9.59137e-10 (rank : 698)	NC score	0.695899 (rank : 797)
Query Neighborhood Hits	1311	Target Neighborhood Hits	983	Shared Neighborhood Hits	790
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

DYR1A_HUMAN
θ value	9.59137e-10 (rank : 699)	NC score	0.843613 (rank : 553)
Query Neighborhood Hits	1311	Target Neighborhood Hits	764	Shared Neighborhood Hits	752
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	9.59137e-10 (rank : 700)	NC score	0.843683 (rank : 552)
Query Neighborhood Hits	1311	Target Neighborhood Hits	762	Shared Neighborhood Hits	752
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

ROR2_MOUSE
θ value	9.59137e-10 (rank : 701)	NC score	0.731925 (rank : 761)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1000	Shared Neighborhood Hits	768
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ZAP70_HUMAN
θ value	9.59137e-10 (rank : 702)	NC score	0.831022 (rank : 577)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	812
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ALK_MOUSE
θ value	1.25267e-09 (rank : 703)	NC score	0.740266 (rank : 748)
Query Neighborhood Hits	1311	Target Neighborhood Hits	811	Shared Neighborhood Hits	744
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

HIPK1_HUMAN
θ value	1.25267e-09 (rank : 704)	NC score	0.846089 (rank : 545)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	786
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	1.25267e-09 (rank : 705)	NC score	0.846028 (rank : 546)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	787
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

TRIB2_HUMAN
θ value	1.25267e-09 (rank : 706)	NC score	0.818664 (rank : 609)
Query Neighborhood Hits	1311	Target Neighborhood Hits	657	Shared Neighborhood Hits	653
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	1.25267e-09 (rank : 707)	NC score	0.817898 (rank : 610)
Query Neighborhood Hits	1311	Target Neighborhood Hits	653	Shared Neighborhood Hits	649
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

AVR2A_HUMAN
θ value	1.63604e-09 (rank : 708)	NC score	0.787608 (rank : 663)
Query Neighborhood Hits	1311	Target Neighborhood Hits	767	Shared Neighborhood Hits	763
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	1.63604e-09 (rank : 709)	NC score	0.787622 (rank : 662)
Query Neighborhood Hits	1311	Target Neighborhood Hits	767	Shared Neighborhood Hits	763
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

BMR1A_HUMAN
θ value	1.63604e-09 (rank : 710)	NC score	0.772110 (rank : 702)
Query Neighborhood Hits	1311	Target Neighborhood Hits	759	Shared Neighborhood Hits	749
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	1.63604e-09 (rank : 711)	NC score	0.770915 (rank : 705)
Query Neighborhood Hits	1311	Target Neighborhood Hits	758	Shared Neighborhood Hits	749
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

DDR2_HUMAN
θ value	1.63604e-09 (rank : 712)	NC score	0.771521 (rank : 703)
Query Neighborhood Hits	1311	Target Neighborhood Hits	818	Shared Neighborhood Hits	776
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DYR1B_MOUSE
θ value	1.63604e-09 (rank : 713)	NC score	0.855567 (rank : 530)
Query Neighborhood Hits	1311	Target Neighborhood Hits	799	Shared Neighborhood Hits	764
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

ERN1_MOUSE
θ value	1.63604e-09 (rank : 714)	NC score	0.901025 (rank : 458)
Query Neighborhood Hits	1311	Target Neighborhood Hits	823	Shared Neighborhood Hits	811
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

KSYK_HUMAN
θ value	1.63604e-09 (rank : 715)	NC score	0.830952 (rank : 578)
Query Neighborhood Hits	1311	Target Neighborhood Hits	901	Shared Neighborhood Hits	811
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	1.63604e-09 (rank : 716)	NC score	0.830812 (rank : 579)
Query Neighborhood Hits	1311	Target Neighborhood Hits	944	Shared Neighborhood Hits	812
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

RIPK2_MOUSE
θ value	1.63604e-09 (rank : 717)	NC score	0.853463 (rank : 533)
Query Neighborhood Hits	1311	Target Neighborhood Hits	776	Shared Neighborhood Hits	755
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

ROR2_HUMAN
θ value	1.63604e-09 (rank : 718)	NC score	0.755949 (rank : 731)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1014	Shared Neighborhood Hits	791
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

EPHAA_HUMAN
θ value	2.13673e-09 (rank : 719)	NC score	0.675768 (rank : 802)
Query Neighborhood Hits	1311	Target Neighborhood Hits	960	Shared Neighborhood Hits	739
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

MOS_HUMAN
θ value	2.13673e-09 (rank : 720)	NC score	0.900881 (rank : 461)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	827
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ROR1_HUMAN
θ value	2.13673e-09 (rank : 721)	NC score	0.777476 (rank : 686)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1018	Shared Neighborhood Hits	806
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

AL2S2_MOUSE
θ value	2.79066e-09 (rank : 722)	NC score	0.842017 (rank : 558)
Query Neighborhood Hits	1311	Target Neighborhood Hits	709	Shared Neighborhood Hits	697
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

BMR1B_MOUSE
θ value	2.79066e-09 (rank : 723)	NC score	0.760692 (rank : 720)
Query Neighborhood Hits	1311	Target Neighborhood Hits	758	Shared Neighborhood Hits	748
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

PRP4B_HUMAN
θ value	2.79066e-09 (rank : 724)	NC score	0.842777 (rank : 557)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1030	Shared Neighborhood Hits	824
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	2.79066e-09 (rank : 725)	NC score	0.841048 (rank : 559)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1040	Shared Neighborhood Hits	821
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

RIPK2_HUMAN
θ value	2.79066e-09 (rank : 726)	NC score	0.850723 (rank : 540)
Query Neighborhood Hits	1311	Target Neighborhood Hits	774	Shared Neighborhood Hits	756
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

BMR1B_HUMAN
θ value	3.64472e-09 (rank : 727)	NC score	0.759091 (rank : 723)
Query Neighborhood Hits	1311	Target Neighborhood Hits	760	Shared Neighborhood Hits	747
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

DDR2_MOUSE
θ value	3.64472e-09 (rank : 728)	NC score	0.777248 (rank : 687)
Query Neighborhood Hits	1311	Target Neighborhood Hits	813	Shared Neighborhood Hits	776
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DYR1B_HUMAN
θ value	3.64472e-09 (rank : 729)	NC score	0.853021 (rank : 534)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	765
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

KIT_MOUSE
θ value	3.64472e-09 (rank : 730)	NC score	0.725181 (rank : 770)
Query Neighborhood Hits	1311	Target Neighborhood Hits	949	Shared Neighborhood Hits	793
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

ROR1_MOUSE
θ value	3.64472e-09 (rank : 731)	NC score	0.779328 (rank : 681)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1025	Shared Neighborhood Hits	809
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

AVR2B_HUMAN
θ value	4.76016e-09 (rank : 732)	NC score	0.768254 (rank : 709)
Query Neighborhood Hits	1311	Target Neighborhood Hits	748	Shared Neighborhood Hits	740
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	4.76016e-09 (rank : 733)	NC score	0.768487 (rank : 708)
Query Neighborhood Hits	1311	Target Neighborhood Hits	749	Shared Neighborhood Hits	740
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

CSF1R_HUMAN
θ value	4.76016e-09 (rank : 734)	NC score	0.702307 (rank : 790)
Query Neighborhood Hits	1311	Target Neighborhood Hits	943	Shared Neighborhood Hits	790
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSK22_MOUSE
θ value	4.76016e-09 (rank : 735)	NC score	0.868863 (rank : 516)
Query Neighborhood Hits	1311	Target Neighborhood Hits	758	Shared Neighborhood Hits	758
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

FLT3_MOUSE
θ value	4.76016e-09 (rank : 736)	NC score	0.723644 (rank : 773)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	788
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

ACV1B_HUMAN
θ value	6.21693e-09 (rank : 737)	NC score	0.752338 (rank : 737)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	749
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	6.21693e-09 (rank : 738)	NC score	0.752446 (rank : 736)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	748
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

LTK_HUMAN
θ value	6.21693e-09 (rank : 739)	NC score	0.733575 (rank : 756)
Query Neighborhood Hits	1311	Target Neighborhood Hits	774	Shared Neighborhood Hits	751
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LRRK1_MOUSE
θ value	8.11959e-09 (rank : 740)	NC score	0.810348 (rank : 620)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1267	Shared Neighborhood Hits	819
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LTK_MOUSE
θ value	8.11959e-09 (rank : 741)	NC score	0.738857 (rank : 749)
Query Neighborhood Hits	1311	Target Neighborhood Hits	770	Shared Neighborhood Hits	744
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

CSK22_HUMAN
θ value	1.06045e-08 (rank : 742)	NC score	0.868326 (rank : 521)
Query Neighborhood Hits	1311	Target Neighborhood Hits	758	Shared Neighborhood Hits	758
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

E2AK1_HUMAN
θ value	1.06045e-08 (rank : 743)	NC score	0.913415 (rank : 395)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	819
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

VGFR3_MOUSE
θ value	1.38499e-08 (rank : 744)	NC score	0.732109 (rank : 759)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1056	Shared Neighborhood Hits	793
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

MOS_MOUSE
θ value	1.80886e-08 (rank : 745)	NC score	0.901406 (rank : 456)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

VGFR3_HUMAN
θ value	1.80886e-08 (rank : 746)	NC score	0.729927 (rank : 763)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1037	Shared Neighborhood Hits	795
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

E2AK1_MOUSE
θ value	2.36244e-08 (rank : 747)	NC score	0.915257 (rank : 384)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	813
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

KSR1_MOUSE
θ value	2.36244e-08 (rank : 748)	NC score	0.854622 (rank : 531)
Query Neighborhood Hits	1311	Target Neighborhood Hits	870	Shared Neighborhood Hits	807
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

PGFRA_MOUSE
θ value	2.36244e-08 (rank : 749)	NC score	0.735284 (rank : 753)
Query Neighborhood Hits	1311	Target Neighborhood Hits	975	Shared Neighborhood Hits	792
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

CSK21_HUMAN
θ value	3.08544e-08 (rank : 750)	NC score	0.875307 (rank : 511)
Query Neighborhood Hits	1311	Target Neighborhood Hits	772	Shared Neighborhood Hits	766
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	3.08544e-08 (rank : 751)	NC score	0.876067 (rank : 509)
Query Neighborhood Hits	1311	Target Neighborhood Hits	770	Shared Neighborhood Hits	766
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

LRRK1_HUMAN
θ value	4.0297e-08 (rank : 752)	NC score	0.811753 (rank : 616)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1237	Shared Neighborhood Hits	814
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

PGFRA_HUMAN
θ value	6.87365e-08 (rank : 753)	NC score	0.736483 (rank : 751)
Query Neighborhood Hits	1311	Target Neighborhood Hits	980	Shared Neighborhood Hits	796
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

VGFR2_MOUSE
θ value	6.87365e-08 (rank : 754)	NC score	0.721458 (rank : 775)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1089	Shared Neighborhood Hits	798
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

ILK1_HUMAN
θ value	8.97725e-08 (rank : 755)	NC score	0.533077 (rank : 830)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	592
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
θ value	8.97725e-08 (rank : 756)	NC score	0.531571 (rank : 831)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	593
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ACV1C_HUMAN
θ value	1.17247e-07 (rank : 757)	NC score	0.698005 (rank : 794)
Query Neighborhood Hits	1311	Target Neighborhood Hits	709	Shared Neighborhood Hits	695
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ERN2_MOUSE
θ value	1.53129e-07 (rank : 758)	NC score	0.890109 (rank : 493)
Query Neighborhood Hits	1311	Target Neighborhood Hits	825	Shared Neighborhood Hits	810
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

NRBP_HUMAN
θ value	1.53129e-07 (rank : 759)	NC score	0.581010 (rank : 814)
Query Neighborhood Hits	1311	Target Neighborhood Hits	448	Shared Neighborhood Hits	425
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
θ value	1.53129e-07 (rank : 760)	NC score	0.578454 (rank : 815)
Query Neighborhood Hits	1311	Target Neighborhood Hits	442	Shared Neighborhood Hits	421
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

RPKL1_MOUSE
θ value	3.41135e-07 (rank : 761)	NC score	0.761940 (rank : 718)
Query Neighborhood Hits	1311	Target Neighborhood Hits	704	Shared Neighborhood Hits	654
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

VGFR2_HUMAN
θ value	3.41135e-07 (rank : 762)	NC score	0.716605 (rank : 779)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1103	Shared Neighborhood Hits	799
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

ACVR1_MOUSE
θ value	4.45536e-07 (rank : 763)	NC score	0.777497 (rank : 685)
Query Neighborhood Hits	1311	Target Neighborhood Hits	768	Shared Neighborhood Hits	760
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

IRAK3_MOUSE
θ value	4.45536e-07 (rank : 764)	NC score	0.724113 (rank : 772)
Query Neighborhood Hits	1311	Target Neighborhood Hits	628	Shared Neighborhood Hits	610
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KSR1_HUMAN
θ value	4.45536e-07 (rank : 765)	NC score	0.844243 (rank : 550)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	792
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

ACVR1_HUMAN
θ value	5.81887e-07 (rank : 766)	NC score	0.772607 (rank : 701)
Query Neighborhood Hits	1311	Target Neighborhood Hits	760	Shared Neighborhood Hits	754
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

KS6C1_MOUSE
θ value	5.81887e-07 (rank : 767)	NC score	0.737656 (rank : 750)
Query Neighborhood Hits	1311	Target Neighborhood Hits	700	Shared Neighborhood Hits	635
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

NTKL_MOUSE
θ value	5.81887e-07 (rank : 768)	NC score	0.414206 (rank : 838)
Query Neighborhood Hits	1311	Target Neighborhood Hits	326	Shared Neighborhood Hits	298
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

TGFR2_MOUSE
θ value	5.81887e-07 (rank : 769)	NC score	0.782980 (rank : 671)
Query Neighborhood Hits	1311	Target Neighborhood Hits	748	Shared Neighborhood Hits	742
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

ACV1C_MOUSE
θ value	7.59969e-07 (rank : 770)	NC score	0.702212 (rank : 791)
Query Neighborhood Hits	1311	Target Neighborhood Hits	715	Shared Neighborhood Hits	702
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

RYK_MOUSE
θ value	7.59969e-07 (rank : 771)	NC score	0.691198 (rank : 799)
Query Neighborhood Hits	1311	Target Neighborhood Hits	715	Shared Neighborhood Hits	703
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

TGFR2_HUMAN
θ value	7.59969e-07 (rank : 772)	NC score	0.783146 (rank : 670)
Query Neighborhood Hits	1311	Target Neighborhood Hits	748	Shared Neighborhood Hits	741
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

FLT3_HUMAN
θ value	9.92553e-07 (rank : 773)	NC score	0.726896 (rank : 767)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	787
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

BMPR2_HUMAN
θ value	2.88788e-06 (rank : 774)	NC score	0.744756 (rank : 743)
Query Neighborhood Hits	1311	Target Neighborhood Hits	736	Shared Neighborhood Hits	710
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

PGFRB_HUMAN
θ value	2.88788e-06 (rank : 775)	NC score	0.726809 (rank : 768)
Query Neighborhood Hits	1311	Target Neighborhood Hits	962	Shared Neighborhood Hits	787
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

RIPK3_HUMAN
θ value	2.88788e-06 (rank : 776)	NC score	0.882880 (rank : 502)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	807
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

RYK_HUMAN
θ value	3.77169e-06 (rank : 777)	NC score	0.675811 (rank : 801)
Query Neighborhood Hits	1311	Target Neighborhood Hits	701	Shared Neighborhood Hits	691
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

ILK2_HUMAN
θ value	4.92598e-06 (rank : 778)	NC score	0.516049 (rank : 832)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	583
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

RIPK3_MOUSE
θ value	4.92598e-06 (rank : 779)	NC score	0.880148 (rank : 505)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	808
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

PGFRB_MOUSE
θ value	6.43352e-06 (rank : 780)	NC score	0.725393 (rank : 769)
Query Neighborhood Hits	1311	Target Neighborhood Hits	960	Shared Neighborhood Hits	791
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

RPKL1_HUMAN
θ value	6.43352e-06 (rank : 781)	NC score	0.755145 (rank : 733)
Query Neighborhood Hits	1311	Target Neighborhood Hits	708	Shared Neighborhood Hits	655
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

TRIB3_MOUSE
θ value	6.43352e-06 (rank : 782)	NC score	0.764916 (rank : 713)
Query Neighborhood Hits	1311	Target Neighborhood Hits	578	Shared Neighborhood Hits	574
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

IRAK3_HUMAN
θ value	8.40245e-06 (rank : 783)	NC score	0.716503 (rank : 780)
Query Neighborhood Hits	1311	Target Neighborhood Hits	644	Shared Neighborhood Hits	632
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

BMPR2_MOUSE
θ value	1.09739e-05 (rank : 784)	NC score	0.742125 (rank : 746)
Query Neighborhood Hits	1311	Target Neighborhood Hits	738	Shared Neighborhood Hits	709
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

KS6C1_HUMAN
θ value	1.09739e-05 (rank : 785)	NC score	0.731985 (rank : 760)
Query Neighborhood Hits	1311	Target Neighborhood Hits	682	Shared Neighborhood Hits	637
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

INCE_MOUSE
θ value	1.43324e-05 (rank : 786)	NC score	0.072100 (rank : 902)
Query Neighborhood Hits	1311	Target Neighborhood Hits	903	Shared Neighborhood Hits	219
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

NTKL_HUMAN
θ value	1.43324e-05 (rank : 787)	NC score	0.326842 (rank : 845)
Query Neighborhood Hits	1311	Target Neighborhood Hits	266	Shared Neighborhood Hits	228
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

ACVL1_MOUSE
θ value	1.87187e-05 (rank : 788)	NC score	0.741771 (rank : 747)
Query Neighborhood Hits	1311	Target Neighborhood Hits	739	Shared Neighborhood Hits	736
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ANPRA_MOUSE
θ value	1.87187e-05 (rank : 789)	NC score	0.542403 (rank : 827)
Query Neighborhood Hits	1311	Target Neighborhood Hits	600	Shared Neighborhood Hits	540
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

SMC1A_MOUSE
θ value	1.87187e-05 (rank : 790)	NC score	0.059333 (rank : 975)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1384	Shared Neighborhood Hits	303
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

CDC7_MOUSE
θ value	3.19293e-05 (rank : 791)	NC score	0.725121 (rank : 771)
Query Neighborhood Hits	1311	Target Neighborhood Hits	641	Shared Neighborhood Hits	631
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

ANPRA_HUMAN
θ value	4.1701e-05 (rank : 792)	NC score	0.543324 (rank : 826)
Query Neighborhood Hits	1311	Target Neighborhood Hits	612	Shared Neighborhood Hits	548
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

GUC2C_HUMAN
θ value	4.1701e-05 (rank : 793)	NC score	0.590252 (rank : 812)
Query Neighborhood Hits	1311	Target Neighborhood Hits	624	Shared Neighborhood Hits	586
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

ACVL1_HUMAN
θ value	7.1131e-05 (rank : 794)	NC score	0.721255 (rank : 777)
Query Neighborhood Hits	1311	Target Neighborhood Hits	716	Shared Neighborhood Hits	711
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

EPHB6_HUMAN
θ value	7.1131e-05 (rank : 795)	NC score	0.646980 (rank : 808)
Query Neighborhood Hits	1311	Target Neighborhood Hits	912	Shared Neighborhood Hits	683
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

IF2P_HUMAN
θ value	7.1131e-05 (rank : 796)	NC score	0.057792 (rank : 990)
Query Neighborhood Hits	1311	Target Neighborhood Hits	889	Shared Neighborhood Hits	199
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

TRHY_HUMAN
θ value	9.29e-05 (rank : 797)	NC score	0.068874 (rank : 910)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1385	Shared Neighborhood Hits	267
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

CDC7_HUMAN
θ value	0.000121331 (rank : 798)	NC score	0.734032 (rank : 755)
Query Neighborhood Hits	1311	Target Neighborhood Hits	652	Shared Neighborhood Hits	634
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

IWS1_MOUSE
θ value	0.000121331 (rank : 799)	NC score	0.046804 (rank : 1128)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1258	Shared Neighborhood Hits	273
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TPR_HUMAN
θ value	0.000121331 (rank : 800)	NC score	0.056294 (rank : 1011)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1921	Shared Neighborhood Hits	381
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TTBK1_HUMAN
θ value	0.000121331 (rank : 801)	NC score	0.748367 (rank : 741)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1058	Shared Neighborhood Hits	740
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

EPHB6_MOUSE
θ value	0.000158464 (rank : 802)	NC score	0.663390 (rank : 804)
Query Neighborhood Hits	1311	Target Neighborhood Hits	906	Shared Neighborhood Hits	710
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

INCE_HUMAN
θ value	0.000158464 (rank : 803)	NC score	0.069255 (rank : 907)
Query Neighborhood Hits	1311	Target Neighborhood Hits	978	Shared Neighborhood Hits	222
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

KC1AL_HUMAN
θ value	0.000158464 (rank : 804)	NC score	0.713974 (rank : 781)
Query Neighborhood Hits	1311	Target Neighborhood Hits	734	Shared Neighborhood Hits	727
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

TTBK2_MOUSE
θ value	0.000158464 (rank : 805)	NC score	0.734221 (rank : 754)
Query Neighborhood Hits	1311	Target Neighborhood Hits	811	Shared Neighborhood Hits	697
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TTBK2_HUMAN
θ value	0.00020696 (rank : 806)	NC score	0.736422 (rank : 752)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	705
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

GUC2F_HUMAN
θ value	0.000270298 (rank : 807)	NC score	0.633043 (rank : 809)
Query Neighborhood Hits	1311	Target Neighborhood Hits	740	Shared Neighborhood Hits	679
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

MYST4_HUMAN
θ value	0.000270298 (rank : 808)	NC score	0.022067 (rank : 1277)
Query Neighborhood Hits	1311	Target Neighborhood Hits	671	Shared Neighborhood Hits	154
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

PINK1_HUMAN
θ value	0.00035302 (rank : 809)	NC score	0.797707 (rank : 644)
Query Neighborhood Hits	1311	Target Neighborhood Hits	741	Shared Neighborhood Hits	720
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PTPRG_HUMAN
θ value	0.000786445 (rank : 810)	NC score	0.001358 (rank : 1452)
Query Neighborhood Hits	1311	Target Neighborhood Hits	231	Shared Neighborhood Hits	37
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

KC1A_HUMAN
θ value	0.00102713 (rank : 811)	NC score	0.713142 (rank : 783)
Query Neighborhood Hits	1311	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	0.00102713 (rank : 812)	NC score	0.713142 (rank : 784)
Query Neighborhood Hits	1311	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

TRIB3_HUMAN
θ value	0.00102713 (rank : 813)	NC score	0.732134 (rank : 758)
Query Neighborhood Hits	1311	Target Neighborhood Hits	519	Shared Neighborhood Hits	515
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

BAZ2B_HUMAN
θ value	0.00134147 (rank : 814)	NC score	0.042772 (rank : 1156)
Query Neighborhood Hits	1311	Target Neighborhood Hits	803	Shared Neighborhood Hits	216
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

DSPP_MOUSE
θ value	0.00134147 (rank : 815)	NC score	0.032358 (rank : 1211)
Query Neighborhood Hits	1311	Target Neighborhood Hits	491	Shared Neighborhood Hits	104
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

KC1G2_HUMAN
θ value	0.00134147 (rank : 816)	NC score	0.663166 (rank : 805)
Query Neighborhood Hits	1311	Target Neighborhood Hits	693	Shared Neighborhood Hits	690
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

MY18A_HUMAN
θ value	0.00134147 (rank : 817)	NC score	0.064555 (rank : 929)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1929	Shared Neighborhood Hits	407
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

AMHR2_HUMAN
θ value	0.00175202 (rank : 818)	NC score	0.647515 (rank : 807)
Query Neighborhood Hits	1311	Target Neighborhood Hits	715	Shared Neighborhood Hits	660
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

ERCC5_HUMAN
θ value	0.00175202 (rank : 819)	NC score	0.020302 (rank : 1289)
Query Neighborhood Hits	1311	Target Neighborhood Hits	162	Shared Neighborhood Hits	54
SwissProt Accessions	P28715, Q7Z2V3, Q8IZL6, Q8N1B7, Q9HD59	Gene names	ERCC5, XPG, XPGC
Domain Architecture
Description	DNA-repair protein complementing XP-G cells (Xeroderma pigmentosum group G-complementing protein) (DNA excision repair protein ERCC-5).

GUC2G_MOUSE
θ value	0.00175202 (rank : 820)	NC score	0.559499 (rank : 820)
Query Neighborhood Hits	1311	Target Neighborhood Hits	644	Shared Neighborhood Hits	585
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

STK31_HUMAN
θ value	0.00175202 (rank : 821)	NC score	0.403036 (rank : 839)
Query Neighborhood Hits	1311	Target Neighborhood Hits	570	Shared Neighborhood Hits	423
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

BUB1_HUMAN
θ value	0.00228821 (rank : 822)	NC score	0.423694 (rank : 837)
Query Neighborhood Hits	1311	Target Neighborhood Hits	543	Shared Neighborhood Hits	424
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

IRAK2_HUMAN
θ value	0.00298849 (rank : 823)	NC score	0.742579 (rank : 745)
Query Neighborhood Hits	1311	Target Neighborhood Hits	714	Shared Neighborhood Hits	678
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

TEX14_MOUSE
θ value	0.00298849 (rank : 824)	NC score	0.583784 (rank : 813)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1333	Shared Neighborhood Hits	778
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

GOGA1_HUMAN
θ value	0.00390308 (rank : 825)	NC score	0.056032 (rank : 1016)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1222	Shared Neighborhood Hits	273
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

UBP37_HUMAN
θ value	0.00390308 (rank : 826)	NC score	0.005184 (rank : 1403)
Query Neighborhood Hits	1311	Target Neighborhood Hits	208	Shared Neighborhood Hits	52
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

DSPP_HUMAN
θ value	0.00509761 (rank : 827)	NC score	0.030564 (rank : 1226)
Query Neighborhood Hits	1311	Target Neighborhood Hits	645	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

KC1G2_MOUSE
θ value	0.00509761 (rank : 828)	NC score	0.664098 (rank : 803)
Query Neighborhood Hits	1311	Target Neighborhood Hits	695	Shared Neighborhood Hits	690
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

BUB1_MOUSE
θ value	0.00665767 (rank : 829)	NC score	0.602071 (rank : 811)
Query Neighborhood Hits	1311	Target Neighborhood Hits	583	Shared Neighborhood Hits	543
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

GOGA3_MOUSE
θ value	0.00665767 (rank : 830)	NC score	0.049319 (rank : 1110)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1437	Shared Neighborhood Hits	294
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

KIF4A_HUMAN
θ value	0.00665767 (rank : 831)	NC score	0.039157 (rank : 1178)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1159	Shared Neighborhood Hits	275
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MY18A_MOUSE
θ value	0.00665767 (rank : 832)	NC score	0.064050 (rank : 932)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1989	Shared Neighborhood Hits	416
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

STK31_MOUSE
θ value	0.00665767 (rank : 833)	NC score	0.344321 (rank : 843)
Query Neighborhood Hits	1311	Target Neighborhood Hits	474	Shared Neighborhood Hits	357
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

MYT1L_HUMAN
θ value	0.00869519 (rank : 834)	NC score	0.022992 (rank : 1271)
Query Neighborhood Hits	1311	Target Neighborhood Hits	471	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UL68, Q6IQ17, Q9UPP6	Gene names	MYT1L, KIAA1106
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L).

ENAH_MOUSE
θ value	0.0113563 (rank : 835)	NC score	0.038057 (rank : 1186)
Query Neighborhood Hits	1311	Target Neighborhood Hits	919	Shared Neighborhood Hits	182
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

KC1E_HUMAN
θ value	0.0113563 (rank : 836)	NC score	0.708808 (rank : 787)
Query Neighborhood Hits	1311	Target Neighborhood Hits	732	Shared Neighborhood Hits	723
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	0.0113563 (rank : 837)	NC score	0.708782 (rank : 788)
Query Neighborhood Hits	1311	Target Neighborhood Hits	728	Shared Neighborhood Hits	723
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1G3_HUMAN
θ value	0.0113563 (rank : 838)	NC score	0.690229 (rank : 800)
Query Neighborhood Hits	1311	Target Neighborhood Hits	711	Shared Neighborhood Hits	706
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

PINK1_MOUSE
θ value	0.0113563 (rank : 839)	NC score	0.811029 (rank : 619)
Query Neighborhood Hits	1311	Target Neighborhood Hits	726	Shared Neighborhood Hits	723
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

GCC2_MOUSE
θ value	0.0148317 (rank : 840)	NC score	0.049071 (rank : 1114)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1619	Shared Neighborhood Hits	313
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

NRDC_HUMAN
θ value	0.0148317 (rank : 841)	NC score	0.014112 (rank : 1329)
Query Neighborhood Hits	1311	Target Neighborhood Hits	60	Shared Neighborhood Hits	15
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_MOUSE
θ value	0.0148317 (rank : 842)	NC score	0.014500 (rank : 1328)
Query Neighborhood Hits	1311	Target Neighborhood Hits	96	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

TEX14_HUMAN
θ value	0.0148317 (rank : 843)	NC score	0.538936 (rank : 828)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1103	Shared Neighborhood Hits	697
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

KC1G1_MOUSE
θ value	0.0193708 (rank : 844)	NC score	0.697788 (rank : 795)
Query Neighborhood Hits	1311	Target Neighborhood Hits	713	Shared Neighborhood Hits	705
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

PLEC1_HUMAN
θ value	0.0193708 (rank : 845)	NC score	0.039779 (rank : 1174)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1326	Shared Neighborhood Hits	247
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

TCRG1_HUMAN
θ value	0.0193708 (rank : 846)	NC score	0.064024 (rank : 933)
Query Neighborhood Hits	1311	Target Neighborhood Hits	929	Shared Neighborhood Hits	252
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	0.0193708 (rank : 847)	NC score	0.065131 (rank : 925)
Query Neighborhood Hits	1311	Target Neighborhood Hits	947	Shared Neighborhood Hits	252
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

NFM_HUMAN
θ value	0.0252991 (rank : 848)	NC score	0.030396 (rank : 1228)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1328	Shared Neighborhood Hits	292
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

PELP1_MOUSE
θ value	0.0252991 (rank : 849)	NC score	0.025898 (rank : 1253)
Query Neighborhood Hits	1311	Target Neighborhood Hits	709	Shared Neighborhood Hits	129
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

REST_HUMAN
θ value	0.0252991 (rank : 850)	NC score	0.051657 (rank : 1070)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1605	Shared Neighborhood Hits	334
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SCYL2_HUMAN
θ value	0.0252991 (rank : 851)	NC score	0.648682 (rank : 806)
Query Neighborhood Hits	1311	Target Neighborhood Hits	632	Shared Neighborhood Hits	577
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

RAD50_HUMAN
θ value	0.0330416 (rank : 852)	NC score	0.051943 (rank : 1066)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1317	Shared Neighborhood Hits	296
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RB6I2_HUMAN
θ value	0.0330416 (rank : 853)	NC score	0.056394 (rank : 1010)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1584	Shared Neighborhood Hits	328
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

CASP_MOUSE
θ value	0.0431538 (rank : 854)	NC score	0.051921 (rank : 1067)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1152	Shared Neighborhood Hits	279
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CCD41_MOUSE
θ value	0.0431538 (rank : 855)	NC score	0.059451 (rank : 973)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1399	Shared Neighborhood Hits	326
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

ENAH_HUMAN
θ value	0.0431538 (rank : 856)	NC score	0.057180 (rank : 999)
Query Neighborhood Hits	1311	Target Neighborhood Hits	784	Shared Neighborhood Hits	199
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

GUC2D_HUMAN
θ value	0.0431538 (rank : 857)	NC score	0.574648 (rank : 816)
Query Neighborhood Hits	1311	Target Neighborhood Hits	715	Shared Neighborhood Hits	666
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

KC1G1_HUMAN
θ value	0.0431538 (rank : 858)	NC score	0.696018 (rank : 796)
Query Neighborhood Hits	1311	Target Neighborhood Hits	708	Shared Neighborhood Hits	703
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

RPGR1_MOUSE
θ value	0.0431538 (rank : 859)	NC score	0.040252 (rank : 1168)
Query Neighborhood Hits	1311	Target Neighborhood Hits	713	Shared Neighborhood Hits	199
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SCYL2_MOUSE
θ value	0.0431538 (rank : 860)	NC score	0.626752 (rank : 810)
Query Neighborhood Hits	1311	Target Neighborhood Hits	603	Shared Neighborhood Hits	551
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SFR17_HUMAN
θ value	0.0431538 (rank : 861)	NC score	0.040247 (rank : 1169)
Query Neighborhood Hits	1311	Target Neighborhood Hits	325	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TF01, Q5T064, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8TF00, Q96K10, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3	Gene names	SRRP130, C6orf111
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 130 (Serine-arginine-rich- splicing regulatory protein 130) (SRrp130) (SR-rich protein) (SR- related protein).

ULE1B_HUMAN
θ value	0.0431538 (rank : 862)	NC score	0.010954 (rank : 1351)
Query Neighborhood Hits	1311	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

VRK1_MOUSE
θ value	0.0431538 (rank : 863)	NC score	0.504960 (rank : 835)
Query Neighborhood Hits	1311	Target Neighborhood Hits	583	Shared Neighborhood Hits	575
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK2_HUMAN
θ value	0.0431538 (rank : 864)	NC score	0.508844 (rank : 834)
Query Neighborhood Hits	1311	Target Neighborhood Hits	582	Shared Neighborhood Hits	563
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

BRE1A_MOUSE
θ value	0.0563607 (rank : 865)	NC score	0.043714 (rank : 1150)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1025	Shared Neighborhood Hits	206
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CALD1_HUMAN
θ value	0.0563607 (rank : 866)	NC score	0.065463 (rank : 924)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	240
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

GUC2E_MOUSE
θ value	0.0563607 (rank : 867)	NC score	0.554047 (rank : 825)
Query Neighborhood Hits	1311	Target Neighborhood Hits	692	Shared Neighborhood Hits	642
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

IF3A_MOUSE
θ value	0.0563607 (rank : 868)	NC score	0.063171 (rank : 939)
Query Neighborhood Hits	1311	Target Neighborhood Hits	871	Shared Neighborhood Hits	238
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

KI21A_MOUSE
θ value	0.0563607 (rank : 869)	NC score	0.024522 (rank : 1261)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1317	Shared Neighborhood Hits	282
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

PELP1_HUMAN
θ value	0.0563607 (rank : 870)	NC score	0.028030 (rank : 1240)
Query Neighborhood Hits	1311	Target Neighborhood Hits	596	Shared Neighborhood Hits	132
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

U2AFM_MOUSE
θ value	0.0563607 (rank : 871)	NC score	0.040199 (rank : 1170)
Query Neighborhood Hits	1311	Target Neighborhood Hits	543	Shared Neighborhood Hits	149
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

ULE1B_MOUSE
θ value	0.0563607 (rank : 872)	NC score	0.015897 (rank : 1319)
Query Neighborhood Hits	1311	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1F9, Q8BVX9	Gene names	Uble1b, Sae2, Uba2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

VRK1_HUMAN
θ value	0.0563607 (rank : 873)	NC score	0.501134 (rank : 836)
Query Neighborhood Hits	1311	Target Neighborhood Hits	584	Shared Neighborhood Hits	574
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

CASP_HUMAN
θ value	0.0736092 (rank : 874)	NC score	0.051529 (rank : 1073)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1131	Shared Neighborhood Hits	280
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

HTSF1_HUMAN
θ value	0.0736092 (rank : 875)	NC score	0.031124 (rank : 1221)
Query Neighborhood Hits	1311	Target Neighborhood Hits	408	Shared Neighborhood Hits	108
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

MYO7A_HUMAN
θ value	0.0736092 (rank : 876)	NC score	0.019204 (rank : 1298)
Query Neighborhood Hits	1311	Target Neighborhood Hits	209	Shared Neighborhood Hits	61
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

NFH_HUMAN
θ value	0.0736092 (rank : 877)	NC score	0.022353 (rank : 1274)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1242	Shared Neighborhood Hits	246
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

AN32B_MOUSE
θ value	0.0961366 (rank : 878)	NC score	0.009838 (rank : 1365)
Query Neighborhood Hits	1311	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

CCDC9_MOUSE
θ value	0.0961366 (rank : 879)	NC score	0.024526 (rank : 1260)
Query Neighborhood Hits	1311	Target Neighborhood Hits	196	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VC31	Gene names	Ccdc9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

CP135_MOUSE
θ value	0.0961366 (rank : 880)	NC score	0.050999 (rank : 1084)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1278	Shared Neighborhood Hits	279
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

LRRF1_HUMAN
θ value	0.0961366 (rank : 881)	NC score	0.038518 (rank : 1182)
Query Neighborhood Hits	1311	Target Neighborhood Hits	625	Shared Neighborhood Hits	215
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

MAP1B_MOUSE
θ value	0.0961366 (rank : 882)	NC score	0.047649 (rank : 1120)
Query Neighborhood Hits	1311	Target Neighborhood Hits	977	Shared Neighborhood Hits	222
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

RB6I2_MOUSE
θ value	0.0961366 (rank : 883)	NC score	0.054164 (rank : 1042)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1433	Shared Neighborhood Hits	299
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

RN5A_MOUSE
θ value	0.0961366 (rank : 884)	NC score	0.354941 (rank : 842)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	611
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

UHMK1_HUMAN
θ value	0.0961366 (rank : 885)	NC score	0.845764 (rank : 547)
Query Neighborhood Hits	1311	Target Neighborhood Hits	808	Shared Neighborhood Hits	774
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ZN291_HUMAN
θ value	0.0961366 (rank : 886)	NC score	0.056266 (rank : 1012)
Query Neighborhood Hits	1311	Target Neighborhood Hits	647	Shared Neighborhood Hits	171
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

BSN_MOUSE
θ value	0.125558 (rank : 887)	NC score	0.044732 (rank : 1143)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2057	Shared Neighborhood Hits	277
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CC47_MOUSE
θ value	0.125558 (rank : 888)	NC score	0.033546 (rank : 1207)
Query Neighborhood Hits	1311	Target Neighborhood Hits	245	Shared Neighborhood Hits	116
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

DESP_HUMAN
θ value	0.125558 (rank : 889)	NC score	0.054178 (rank : 1041)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1470	Shared Neighborhood Hits	320
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

DNJC3_MOUSE
θ value	0.125558 (rank : 890)	NC score	0.000140 (rank : 1462)
Query Neighborhood Hits	1311	Target Neighborhood Hits	230	Shared Neighborhood Hits	38
SwissProt Accessions	Q91YW3, Q60873	Gene names	Dnajc3, P58ipk
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor p58) (Protein kinase inhibitor of 58 kDa).

IF3A_HUMAN
θ value	0.125558 (rank : 891)	NC score	0.062436 (rank : 944)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	238
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

K2002_HUMAN
θ value	0.125558 (rank : 892)	NC score	0.343271 (rank : 844)
Query Neighborhood Hits	1311	Target Neighborhood Hits	274	Shared Neighborhood Hits	261
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

MFAP1_HUMAN
θ value	0.125558 (rank : 893)	NC score	0.050968 (rank : 1086)
Query Neighborhood Hits	1311	Target Neighborhood Hits	321	Shared Neighborhood Hits	125
SwissProt Accessions	P55081	Gene names	MFAP1
Domain Architecture
Description	Microfibrillar-associated protein 1.

MYST3_MOUSE
θ value	0.125558 (rank : 894)	NC score	0.013207 (rank : 1334)
Query Neighborhood Hits	1311	Target Neighborhood Hits	688	Shared Neighborhood Hits	161
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

NFM_MOUSE
θ value	0.125558 (rank : 895)	NC score	0.028084 (rank : 1239)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1159	Shared Neighborhood Hits	276
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

RIMB1_HUMAN
θ value	0.125558 (rank : 896)	NC score	0.061021 (rank : 957)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1479	Shared Neighborhood Hits	306
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SPAG5_MOUSE
θ value	0.125558 (rank : 897)	NC score	0.041277 (rank : 1161)
Query Neighborhood Hits	1311	Target Neighborhood Hits	612	Shared Neighborhood Hits	160
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

TXND2_MOUSE
θ value	0.125558 (rank : 898)	NC score	0.039653 (rank : 1175)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	226
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

UHMK1_MOUSE
θ value	0.125558 (rank : 899)	NC score	0.844271 (rank : 548)
Query Neighborhood Hits	1311	Target Neighborhood Hits	809	Shared Neighborhood Hits	774
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

VRK2_MOUSE
θ value	0.125558 (rank : 900)	NC score	0.513986 (rank : 833)
Query Neighborhood Hits	1311	Target Neighborhood Hits	586	Shared Neighborhood Hits	574
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

DMP1_MOUSE
θ value	0.163984 (rank : 901)	NC score	0.025327 (rank : 1256)
Query Neighborhood Hits	1311	Target Neighborhood Hits	498	Shared Neighborhood Hits	137
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

ESCO1_HUMAN
θ value	0.163984 (rank : 902)	NC score	0.020411 (rank : 1287)
Query Neighborhood Hits	1311	Target Neighborhood Hits	361	Shared Neighborhood Hits	117
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

GOGA4_MOUSE
θ value	0.163984 (rank : 903)	NC score	0.057009 (rank : 1002)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1939	Shared Neighborhood Hits	380
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

ITSN1_MOUSE
θ value	0.163984 (rank : 904)	NC score	0.076375 (rank : 894)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1669	Shared Neighborhood Hits	367
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

KC1D_HUMAN
θ value	0.163984 (rank : 905)	NC score	0.711619 (rank : 785)
Query Neighborhood Hits	1311	Target Neighborhood Hits	737	Shared Neighborhood Hits	721
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	0.163984 (rank : 906)	NC score	0.711607 (rank : 786)
Query Neighborhood Hits	1311	Target Neighborhood Hits	737	Shared Neighborhood Hits	721
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

PEPL_MOUSE
θ value	0.163984 (rank : 907)	NC score	0.055663 (rank : 1022)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1105	Shared Neighborhood Hits	286
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

REN3B_HUMAN
θ value	0.163984 (rank : 908)	NC score	0.059269 (rank : 976)
Query Neighborhood Hits	1311	Target Neighborhood Hits	412	Shared Neighborhood Hits	149
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

TXND2_HUMAN
θ value	0.163984 (rank : 909)	NC score	0.036704 (rank : 1195)
Query Neighborhood Hits	1311	Target Neighborhood Hits	793	Shared Neighborhood Hits	164
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

CCD47_HUMAN
θ value	0.21417 (rank : 910)	NC score	0.022927 (rank : 1272)
Query Neighborhood Hits	1311	Target Neighborhood Hits	119	Shared Neighborhood Hits	65
SwissProt Accessions	Q96A33, Q96D00, Q96JZ7, Q9H3E4, Q9NRG3	Gene names	CCDC47
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor.

CEND3_HUMAN
θ value	0.21417 (rank : 911)	NC score	0.013174 (rank : 1336)
Query Neighborhood Hits	1311	Target Neighborhood Hits	275	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

K2002_MOUSE
θ value	0.21417 (rank : 912)	NC score	0.285684 (rank : 846)
Query Neighborhood Hits	1311	Target Neighborhood Hits	267	Shared Neighborhood Hits	236
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

MAP1A_HUMAN
θ value	0.21417 (rank : 913)	NC score	0.065934 (rank : 922)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1626	Shared Neighborhood Hits	362
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NFH_MOUSE
θ value	0.21417 (rank : 914)	NC score	0.033298 (rank : 1208)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2247	Shared Neighborhood Hits	350
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

SRPK1_HUMAN
θ value	0.21417 (rank : 915)	NC score	0.567231 (rank : 819)
Query Neighborhood Hits	1311	Target Neighborhood Hits	706	Shared Neighborhood Hits	603
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_MOUSE
θ value	0.21417 (rank : 916)	NC score	0.569756 (rank : 818)
Query Neighborhood Hits	1311	Target Neighborhood Hits	639	Shared Neighborhood Hits	584
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

TRI44_HUMAN
θ value	0.21417 (rank : 917)	NC score	0.007689 (rank : 1378)
Query Neighborhood Hits	1311	Target Neighborhood Hits	393	Shared Neighborhood Hits	88
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

WDR43_HUMAN
θ value	0.21417 (rank : 918)	NC score	-0.000167 (rank : 1464)
Query Neighborhood Hits	1311	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

ANK2_HUMAN
θ value	0.279714 (rank : 919)	NC score	0.028811 (rank : 1237)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1615	Shared Neighborhood Hits	251
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CAF1A_MOUSE
θ value	0.279714 (rank : 920)	NC score	0.051547 (rank : 1072)
Query Neighborhood Hits	1311	Target Neighborhood Hits	736	Shared Neighborhood Hits	202
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CENPE_HUMAN
θ value	0.279714 (rank : 921)	NC score	0.046443 (rank : 1134)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2060	Shared Neighborhood Hits	369
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CF153_MOUSE
θ value	0.279714 (rank : 922)	NC score	0.023696 (rank : 1266)
Query Neighborhood Hits	1311	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q3UFY0, Q91X71	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf153 homolog.

CN155_HUMAN
θ value	0.279714 (rank : 923)	NC score	0.023881 (rank : 1264)
Query Neighborhood Hits	1311	Target Neighborhood Hits	385	Shared Neighborhood Hits	65
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CUTL2_MOUSE
θ value	0.279714 (rank : 924)	NC score	0.017908 (rank : 1308)
Query Neighborhood Hits	1311	Target Neighborhood Hits	771	Shared Neighborhood Hits	156
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

GON4L_HUMAN
θ value	0.279714 (rank : 925)	NC score	0.020092 (rank : 1290)
Query Neighborhood Hits	1311	Target Neighborhood Hits	555	Shared Neighborhood Hits	118
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

HTSF1_MOUSE
θ value	0.279714 (rank : 926)	NC score	0.027952 (rank : 1242)
Query Neighborhood Hits	1311	Target Neighborhood Hits	425	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

ITSN1_HUMAN
θ value	0.279714 (rank : 927)	NC score	0.074577 (rank : 898)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1757	Shared Neighborhood Hits	369
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

LUZP1_HUMAN
θ value	0.279714 (rank : 928)	NC score	0.045411 (rank : 1137)
Query Neighborhood Hits	1311	Target Neighborhood Hits	739	Shared Neighborhood Hits	189
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

MYO10_HUMAN
θ value	0.279714 (rank : 929)	NC score	0.038897 (rank : 1179)
Query Neighborhood Hits	1311	Target Neighborhood Hits	920	Shared Neighborhood Hits	243
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYST3_HUMAN
θ value	0.279714 (rank : 930)	NC score	0.014650 (rank : 1326)
Query Neighborhood Hits	1311	Target Neighborhood Hits	772	Shared Neighborhood Hits	148
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

NFL_HUMAN
θ value	0.279714 (rank : 931)	NC score	0.013242 (rank : 1333)
Query Neighborhood Hits	1311	Target Neighborhood Hits	666	Shared Neighborhood Hits	176
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

PHLB1_MOUSE
θ value	0.279714 (rank : 932)	NC score	0.030223 (rank : 1230)
Query Neighborhood Hits	1311	Target Neighborhood Hits	678	Shared Neighborhood Hits	149
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RIMB1_MOUSE
θ value	0.279714 (rank : 933)	NC score	0.064838 (rank : 928)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1376	Shared Neighborhood Hits	311
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RPGR_MOUSE
θ value	0.279714 (rank : 934)	NC score	0.056609 (rank : 1007)
Query Neighborhood Hits	1311	Target Neighborhood Hits	281	Shared Neighborhood Hits	129
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

STK23_HUMAN
θ value	0.279714 (rank : 935)	NC score	0.554426 (rank : 824)
Query Neighborhood Hits	1311	Target Neighborhood Hits	556	Shared Neighborhood Hits	553
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

TCF8_HUMAN
θ value	0.279714 (rank : 936)	NC score	-0.023637 (rank : 1499)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1057	Shared Neighborhood Hits	107
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

UBP8_HUMAN
θ value	0.279714 (rank : 937)	NC score	0.021570 (rank : 1280)
Query Neighborhood Hits	1311	Target Neighborhood Hits	751	Shared Neighborhood Hits	227
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

AP3D1_HUMAN
θ value	0.365318 (rank : 938)	NC score	0.012099 (rank : 1344)
Query Neighborhood Hits	1311	Target Neighborhood Hits	254	Shared Neighborhood Hits	59
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

BPTF_HUMAN
θ value	0.365318 (rank : 939)	NC score	0.023905 (rank : 1263)
Query Neighborhood Hits	1311	Target Neighborhood Hits	786	Shared Neighborhood Hits	180
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

CLUA1_HUMAN
θ value	0.365318 (rank : 940)	NC score	0.026998 (rank : 1246)
Query Neighborhood Hits	1311	Target Neighborhood Hits	236	Shared Neighborhood Hits	81
SwissProt Accessions	Q96AJ1, O75138, Q65ZA3, Q9H8R4, Q9H8T1	Gene names	CLUAP1, KIAA0643
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

CUTL1_HUMAN
θ value	0.365318 (rank : 941)	NC score	0.042478 (rank : 1158)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1574	Shared Neighborhood Hits	311
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

HUWE1_HUMAN
θ value	0.365318 (rank : 942)	NC score	0.003884 (rank : 1419)
Query Neighborhood Hits	1311	Target Neighborhood Hits	443	Shared Neighborhood Hits	78
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	0.365318 (rank : 943)	NC score	0.003849 (rank : 1420)
Query Neighborhood Hits	1311	Target Neighborhood Hits	406	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

MAP1B_HUMAN
θ value	0.365318 (rank : 944)	NC score	0.040098 (rank : 1173)
Query Neighborhood Hits	1311	Target Neighborhood Hits	903	Shared Neighborhood Hits	220
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MDN1_HUMAN
θ value	0.365318 (rank : 945)	NC score	0.026418 (rank : 1251)
Query Neighborhood Hits	1311	Target Neighborhood Hits	662	Shared Neighborhood Hits	171
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

MYT1_HUMAN
θ value	0.365318 (rank : 946)	NC score	0.019253 (rank : 1297)
Query Neighborhood Hits	1311	Target Neighborhood Hits	475	Shared Neighborhood Hits	138
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

NONO_MOUSE
θ value	0.365318 (rank : 947)	NC score	0.019047 (rank : 1300)
Query Neighborhood Hits	1311	Target Neighborhood Hits	444	Shared Neighborhood Hits	100
SwissProt Accessions	Q99K48, Q63887, Q9CYQ4, Q9DBP2	Gene names	Nono
Domain Architecture	No domain graphic available
Description	Non-POU domain-containing octamer-binding protein (NonO protein).

RFIP1_HUMAN
θ value	0.365318 (rank : 948)	NC score	0.010830 (rank : 1352)
Query Neighborhood Hits	1311	Target Neighborhood Hits	236	Shared Neighborhood Hits	37
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RP1L1_HUMAN
θ value	0.365318 (rank : 949)	NC score	0.035876 (rank : 1197)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1072	Shared Neighborhood Hits	190
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

SAFB2_HUMAN
θ value	0.365318 (rank : 950)	NC score	0.040321 (rank : 1166)
Query Neighborhood Hits	1311	Target Neighborhood Hits	720	Shared Neighborhood Hits	194
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

SPTN4_HUMAN
θ value	0.365318 (rank : 951)	NC score	0.010382 (rank : 1357)
Query Neighborhood Hits	1311	Target Neighborhood Hits	570	Shared Neighborhood Hits	137
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

TAF3_HUMAN
θ value	0.365318 (rank : 952)	NC score	0.033997 (rank : 1205)
Query Neighborhood Hits	1311	Target Neighborhood Hits	568	Shared Neighborhood Hits	138
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

TAXB1_MOUSE
θ value	0.365318 (rank : 953)	NC score	0.046712 (rank : 1131)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	225
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

ANR12_HUMAN
θ value	0.47712 (rank : 954)	NC score	0.039461 (rank : 1177)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1081	Shared Neighborhood Hits	240
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

BRD4_HUMAN
θ value	0.47712 (rank : 955)	NC score	0.019321 (rank : 1296)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	170
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CAF1A_HUMAN
θ value	0.47712 (rank : 956)	NC score	0.052578 (rank : 1056)
Query Neighborhood Hits	1311	Target Neighborhood Hits	750	Shared Neighborhood Hits	197
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CN145_HUMAN
θ value	0.47712 (rank : 957)	NC score	0.057914 (rank : 986)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1196	Shared Neighborhood Hits	282
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CR034_MOUSE
θ value	0.47712 (rank : 958)	NC score	0.035708 (rank : 1200)
Query Neighborhood Hits	1311	Target Neighborhood Hits	643	Shared Neighborhood Hits	176
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

DHX29_MOUSE
θ value	0.47712 (rank : 959)	NC score	0.003132 (rank : 1429)
Query Neighborhood Hits	1311	Target Neighborhood Hits	103	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9	Gene names	Dhx29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29).

GCP60_HUMAN
θ value	0.47712 (rank : 960)	NC score	0.045907 (rank : 1135)
Query Neighborhood Hits	1311	Target Neighborhood Hits	419	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H3P7, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3	Gene names	ACBD3, GCP60
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

GOGA4_HUMAN
θ value	0.47712 (rank : 961)	NC score	0.057487 (rank : 992)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2034	Shared Neighborhood Hits	376
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

GOGB1_HUMAN
θ value	0.47712 (rank : 962)	NC score	0.054779 (rank : 1033)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2297	Shared Neighborhood Hits	407
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

IFT81_MOUSE
θ value	0.47712 (rank : 963)	NC score	0.056551 (rank : 1008)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	241
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

IWS1_HUMAN
θ value	0.47712 (rank : 964)	NC score	0.046836 (rank : 1127)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1241	Shared Neighborhood Hits	285
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LRCH2_MOUSE
θ value	0.47712 (rank : 965)	NC score	-0.002390 (rank : 1478)
Query Neighborhood Hits	1311	Target Neighborhood Hits	287	Shared Neighborhood Hits	23
SwissProt Accessions	Q3UMG5, Q7TNP9, Q80TC9	Gene names	Lrch2, Kiaa1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

MINT_MOUSE
θ value	0.47712 (rank : 966)	NC score	0.030839 (rank : 1224)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1514	Shared Neighborhood Hits	243
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MYH14_MOUSE
θ value	0.47712 (rank : 967)	NC score	0.043763 (rank : 1149)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1225	Shared Neighborhood Hits	260
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

AN32B_HUMAN
θ value	0.62314 (rank : 968)	NC score	0.006336 (rank : 1392)
Query Neighborhood Hits	1311	Target Neighborhood Hits	243	Shared Neighborhood Hits	32
SwissProt Accessions	Q92688, O00655, P78458, P78459	Gene names	ANP32B, APRIL, PHAPI2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines).

CENPB_HUMAN
θ value	0.62314 (rank : 969)	NC score	0.010605 (rank : 1355)
Query Neighborhood Hits	1311	Target Neighborhood Hits	133	Shared Neighborhood Hits	36
SwissProt Accessions	P07199	Gene names	CENPB
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

CROCC_MOUSE
θ value	0.62314 (rank : 970)	NC score	0.052192 (rank : 1059)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1460	Shared Neighborhood Hits	298
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

DC1I2_HUMAN
θ value	0.62314 (rank : 971)	NC score	0.000964 (rank : 1458)
Query Neighborhood Hits	1311	Target Neighborhood Hits	201	Shared Neighborhood Hits	25
SwissProt Accessions	Q13409, Q96NG7, Q96S87, Q9BXZ5, Q9NT58	Gene names	DYNC1I2, DNCI2, DNCIC2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

DMP1_HUMAN
θ value	0.62314 (rank : 972)	NC score	0.035024 (rank : 1202)
Query Neighborhood Hits	1311	Target Neighborhood Hits	491	Shared Neighborhood Hits	148
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

FEZ1_HUMAN
θ value	0.62314 (rank : 973)	NC score	0.012322 (rank : 1343)
Query Neighborhood Hits	1311	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	Q99689, O00679, O00728, Q6IBI7	Gene names	FEZ1
Domain Architecture	No domain graphic available
Description	Fasciculation and elongation protein zeta 1 (Zygin-1) (Zygin I).

GON4L_MOUSE
θ value	0.62314 (rank : 974)	NC score	0.013181 (rank : 1335)
Query Neighborhood Hits	1311	Target Neighborhood Hits	455	Shared Neighborhood Hits	86
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

MYT1L_MOUSE
θ value	0.62314 (rank : 975)	NC score	0.022073 (rank : 1276)
Query Neighborhood Hits	1311	Target Neighborhood Hits	461	Shared Neighborhood Hits	130
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

MYT1_MOUSE
θ value	0.62314 (rank : 976)	NC score	0.015248 (rank : 1323)
Query Neighborhood Hits	1311	Target Neighborhood Hits	385	Shared Neighborhood Hits	93
SwissProt Accessions	Q8CFC2, O08995, Q8CFH1	Gene names	Myt1, Kiaa0835, Nzf2
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1 (MyT1) (Neural zinc finger factor 2) (NZF-2).

PEPL_HUMAN
θ value	0.62314 (rank : 977)	NC score	0.054224 (rank : 1038)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1141	Shared Neighborhood Hits	290
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

SMC1A_HUMAN
θ value	0.62314 (rank : 978)	NC score	0.055248 (rank : 1027)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1346	Shared Neighborhood Hits	297
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SNUT1_HUMAN
θ value	0.62314 (rank : 979)	NC score	0.009497 (rank : 1369)
Query Neighborhood Hits	1311	Target Neighborhood Hits	129	Shared Neighborhood Hits	38
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

TCAL5_HUMAN
θ value	0.62314 (rank : 980)	NC score	0.032023 (rank : 1212)
Query Neighborhood Hits	1311	Target Neighborhood Hits	806	Shared Neighborhood Hits	210
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

UT14B_MOUSE
θ value	0.62314 (rank : 981)	NC score	0.013099 (rank : 1338)
Query Neighborhood Hits	1311	Target Neighborhood Hits	226	Shared Neighborhood Hits	96
SwissProt Accessions	Q6EJB6, Q6EJB5, Q8BL60	Gene names	Utp14b, Jsd
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog B (Juvenile spermatogonial depletion protein).

VCX3_HUMAN
θ value	0.62314 (rank : 982)	NC score	0.023337 (rank : 1269)
Query Neighborhood Hits	1311	Target Neighborhood Hits	105	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NNX9, Q9P0H4	Gene names	VCX3A, VCX3, VCX8R, VCXA
Domain Architecture	No domain graphic available
Description	Variable charge X-linked protein 3 (VCX-A protein) (Variably charged protein X-A) (Variable charge protein on X with eight repeats) (VCX- 8r).

VCXC_HUMAN
θ value	0.62314 (rank : 983)	NC score	0.024696 (rank : 1258)
Query Neighborhood Hits	1311	Target Neighborhood Hits	139	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H321	Gene names	VCXC
Domain Architecture	No domain graphic available
Description	VCX-C protein (Variably charged protein X-C).

WDR81_MOUSE
θ value	0.62314 (rank : 984)	NC score	-0.000721 (rank : 1466)
Query Neighborhood Hits	1311	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	Q5ND34, Q3TA90, Q3TUS9, Q6KAR1	Gene names	Wdr81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

AN32A_HUMAN
θ value	0.813845 (rank : 985)	NC score	0.003992 (rank : 1415)
Query Neighborhood Hits	1311	Target Neighborhood Hits	234	Shared Neighborhood Hits	28
SwissProt Accessions	P39687	Gene names	ANP32A, C15orf1, LANP, MAPM, PHAP1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein) (Lanp) (Putative HLA-DR-associated protein I) (PHAPI) (Mapmodulin).

ATRX_HUMAN
θ value	0.813845 (rank : 986)	NC score	0.024506 (rank : 1262)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	222
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

BICD1_HUMAN
θ value	0.813845 (rank : 987)	NC score	0.040985 (rank : 1164)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	210
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD1_MOUSE
θ value	0.813845 (rank : 988)	NC score	0.040693 (rank : 1165)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	211
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

CCD11_HUMAN
θ value	0.813845 (rank : 989)	NC score	0.075065 (rank : 896)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	251
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CENPB_MOUSE
θ value	0.813845 (rank : 990)	NC score	0.009803 (rank : 1366)
Query Neighborhood Hits	1311	Target Neighborhood Hits	163	Shared Neighborhood Hits	38
SwissProt Accessions	P27790	Gene names	Cenpb, Cenp-b
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

CING_HUMAN
θ value	0.813845 (rank : 991)	NC score	0.055101 (rank : 1029)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1275	Shared Neighborhood Hits	300
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

DAXX_HUMAN
θ value	0.813845 (rank : 992)	NC score	0.018768 (rank : 1301)
Query Neighborhood Hits	1311	Target Neighborhood Hits	207	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

EHMT2_HUMAN
θ value	0.813845 (rank : 993)	NC score	0.006549 (rank : 1386)
Query Neighborhood Hits	1311	Target Neighborhood Hits	498	Shared Neighborhood Hits	58
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

GBP2_HUMAN
θ value	0.813845 (rank : 994)	NC score	0.021418 (rank : 1281)
Query Neighborhood Hits	1311	Target Neighborhood Hits	349	Shared Neighborhood Hits	119
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

GFAP_MOUSE
θ value	0.813845 (rank : 995)	NC score	0.022647 (rank : 1273)
Query Neighborhood Hits	1311	Target Neighborhood Hits	725	Shared Neighborhood Hits	199
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

IRF2_HUMAN
θ value	0.813845 (rank : 996)	NC score	0.003176 (rank : 1427)
Query Neighborhood Hits	1311	Target Neighborhood Hits	35	Shared Neighborhood Hits	7
SwissProt Accessions	P14316, Q96B99	Gene names	IRF2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

LAP2_MOUSE
θ value	0.813845 (rank : 997)	NC score	-0.005320 (rank : 1490)
Query Neighborhood Hits	1311	Target Neighborhood Hits	482	Shared Neighborhood Hits	43
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

LMNA_MOUSE
θ value	0.813845 (rank : 998)	NC score	0.021345 (rank : 1282)
Query Neighborhood Hits	1311	Target Neighborhood Hits	661	Shared Neighborhood Hits	191
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

MFAP1_MOUSE
θ value	0.813845 (rank : 999)	NC score	0.049075 (rank : 1113)
Query Neighborhood Hits	1311	Target Neighborhood Hits	353	Shared Neighborhood Hits	122
SwissProt Accessions	Q9CQU1, Q3TU29, Q8CCL1, Q9CSJ5	Gene names	Mfap1
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 1.

NUCL_MOUSE
θ value	0.813845 (rank : 1000)	NC score	-0.003621 (rank : 1484)
Query Neighborhood Hits	1311	Target Neighborhood Hits	425	Shared Neighborhood Hits	52
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

RSF1_HUMAN
θ value	0.813845 (rank : 1001)	NC score	0.028513 (rank : 1238)
Query Neighborhood Hits	1311	Target Neighborhood Hits	539	Shared Neighborhood Hits	146
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

SON_HUMAN
θ value	0.813845 (rank : 1002)	NC score	0.024809 (rank : 1257)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1568	Shared Neighborhood Hits	182
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

T2_MOUSE
θ value	0.813845 (rank : 1003)	NC score	0.041039 (rank : 1163)
Query Neighborhood Hits	1311	Target Neighborhood Hits	140	Shared Neighborhood Hits	51
SwissProt Accessions	Q06666	Gene names	Srst, T2
Domain Architecture	No domain graphic available
Description	Octapeptide-repeat protein T2.

TAF3_MOUSE
θ value	0.813845 (rank : 1004)	NC score	0.038781 (rank : 1181)
Query Neighborhood Hits	1311	Target Neighborhood Hits	463	Shared Neighborhood Hits	124
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

TCF8_MOUSE
θ value	0.813845 (rank : 1005)	NC score	-0.024721 (rank : 1500)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1067	Shared Neighborhood Hits	98
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

TRIPB_HUMAN
θ value	0.813845 (rank : 1006)	NC score	0.052125 (rank : 1061)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1587	Shared Neighborhood Hits	325
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

U2AFM_HUMAN
θ value	0.813845 (rank : 1007)	NC score	0.037926 (rank : 1188)
Query Neighborhood Hits	1311	Target Neighborhood Hits	577	Shared Neighborhood Hits	157
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

VCX1_HUMAN
θ value	0.813845 (rank : 1008)	NC score	0.029680 (rank : 1233)
Query Neighborhood Hits	1311	Target Neighborhood Hits	129	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H320, Q9P0H3	Gene names	VCX, VCX1, VCX10R, VCXB1
Domain Architecture	No domain graphic available
Description	Variable charge X-linked protein 1 (VCX-B1 protein) (Variably charged protein X-B1) (Variable charge protein on X with ten repeats) (VCX- 10r).

AFAD_HUMAN
θ value	1.06291 (rank : 1009)	NC score	0.031971 (rank : 1214)
Query Neighborhood Hits	1311	Target Neighborhood Hits	689	Shared Neighborhood Hits	161
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

BSN_HUMAN
θ value	1.06291 (rank : 1010)	NC score	0.047449 (rank : 1122)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1537	Shared Neighborhood Hits	256
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CUTL1_MOUSE
θ value	1.06291 (rank : 1011)	NC score	0.043577 (rank : 1153)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1620	Shared Neighborhood Hits	307
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

ENL_HUMAN
θ value	1.06291 (rank : 1012)	NC score	0.016442 (rank : 1314)
Query Neighborhood Hits	1311	Target Neighborhood Hits	305	Shared Neighborhood Hits	46
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

FAS_MOUSE
θ value	1.06291 (rank : 1013)	NC score	0.000892 (rank : 1459)
Query Neighborhood Hits	1311	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

FEZ1_MOUSE
θ value	1.06291 (rank : 1014)	NC score	0.011284 (rank : 1349)
Query Neighborhood Hits	1311	Target Neighborhood Hits	93	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K0X8	Gene names	Fez1
Domain Architecture	No domain graphic available
Description	Fasciculation and elongation protein zeta 1 (Zygin-1) (Zygin I).

FILA_HUMAN
θ value	1.06291 (rank : 1015)	NC score	0.019344 (rank : 1294)
Query Neighborhood Hits	1311	Target Neighborhood Hits	685	Shared Neighborhood Hits	106
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

HOOK3_HUMAN
θ value	1.06291 (rank : 1016)	NC score	0.040268 (rank : 1167)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1070	Shared Neighborhood Hits	247
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

KMHN1_HUMAN
θ value	1.06291 (rank : 1017)	NC score	0.048984 (rank : 1115)
Query Neighborhood Hits	1311	Target Neighborhood Hits	950	Shared Neighborhood Hits	244
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

LMNA_HUMAN
θ value	1.06291 (rank : 1018)	NC score	0.020751 (rank : 1286)
Query Neighborhood Hits	1311	Target Neighborhood Hits	653	Shared Neighborhood Hits	189
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

LRC56_HUMAN
θ value	1.06291 (rank : 1019)	NC score	0.003070 (rank : 1430)
Query Neighborhood Hits	1311	Target Neighborhood Hits	165	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

NADAP_HUMAN
θ value	1.06291 (rank : 1020)	NC score	0.008985 (rank : 1374)
Query Neighborhood Hits	1311	Target Neighborhood Hits	208	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

PININ_HUMAN
θ value	1.06291 (rank : 1021)	NC score	0.066323 (rank : 920)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	240
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PP2CG_HUMAN
θ value	1.06291 (rank : 1022)	NC score	0.002516 (rank : 1438)
Query Neighborhood Hits	1311	Target Neighborhood Hits	140	Shared Neighborhood Hits	28
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

RIF1_HUMAN
θ value	1.06291 (rank : 1023)	NC score	0.019088 (rank : 1299)
Query Neighborhood Hits	1311	Target Neighborhood Hits	320	Shared Neighborhood Hits	105
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

SAFB2_MOUSE
θ value	1.06291 (rank : 1024)	NC score	0.035275 (rank : 1201)
Query Neighborhood Hits	1311	Target Neighborhood Hits	581	Shared Neighborhood Hits	154
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

SRPK2_HUMAN
θ value	1.06291 (rank : 1025)	NC score	0.558616 (rank : 821)
Query Neighborhood Hits	1311	Target Neighborhood Hits	664	Shared Neighborhood Hits	592
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	1.06291 (rank : 1026)	NC score	0.557795 (rank : 822)
Query Neighborhood Hits	1311	Target Neighborhood Hits	765	Shared Neighborhood Hits	617
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

XE7_HUMAN
θ value	1.06291 (rank : 1027)	NC score	0.059713 (rank : 970)
Query Neighborhood Hits	1311	Target Neighborhood Hits	738	Shared Neighborhood Hits	196
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

YTDC1_HUMAN
θ value	1.06291 (rank : 1028)	NC score	0.022115 (rank : 1275)
Query Neighborhood Hits	1311	Target Neighborhood Hits	458	Shared Neighborhood Hits	136
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

AKAP9_HUMAN
θ value	1.38821 (rank : 1029)	NC score	0.051502 (rank : 1074)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1710	Shared Neighborhood Hits	325
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

ASPH_HUMAN
θ value	1.38821 (rank : 1030)	NC score	0.027730 (rank : 1243)
Query Neighborhood Hits	1311	Target Neighborhood Hits	158	Shared Neighborhood Hits	75
SwissProt Accessions	Q12797	Gene names	ASPH
Domain Architecture
Description	Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta- hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta- dioxygenase).

BAZ1A_HUMAN
θ value	1.38821 (rank : 1031)	NC score	0.026755 (rank : 1250)
Query Neighborhood Hits	1311	Target Neighborhood Hits	693	Shared Neighborhood Hits	186
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

BAZ2A_MOUSE
θ value	1.38821 (rank : 1032)	NC score	0.018240 (rank : 1302)
Query Neighborhood Hits	1311	Target Neighborhood Hits	744	Shared Neighborhood Hits	133
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

BPAEA_MOUSE
θ value	1.38821 (rank : 1033)	NC score	0.049161 (rank : 1112)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1480	Shared Neighborhood Hits	319
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BRE1A_HUMAN
θ value	1.38821 (rank : 1034)	NC score	0.042561 (rank : 1157)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1071	Shared Neighborhood Hits	213
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BTBDC_HUMAN
θ value	1.38821 (rank : 1035)	NC score	0.019326 (rank : 1295)
Query Neighborhood Hits	1311	Target Neighborhood Hits	248	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

CTGE5_MOUSE
θ value	1.38821 (rank : 1036)	NC score	0.032918 (rank : 1209)
Query Neighborhood Hits	1311	Target Neighborhood Hits	928	Shared Neighborhood Hits	232
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

DREB_HUMAN
θ value	1.38821 (rank : 1037)	NC score	0.044188 (rank : 1148)
Query Neighborhood Hits	1311	Target Neighborhood Hits	450	Shared Neighborhood Hits	136
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

E41L2_MOUSE
θ value	1.38821 (rank : 1038)	NC score	0.009009 (rank : 1373)
Query Neighborhood Hits	1311	Target Neighborhood Hits	459	Shared Neighborhood Hits	181
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

GCP60_MOUSE
θ value	1.38821 (rank : 1039)	NC score	0.043098 (rank : 1154)
Query Neighborhood Hits	1311	Target Neighborhood Hits	395	Shared Neighborhood Hits	128
SwissProt Accessions	Q8BMP6, O35371	Gene names	Acbd3, Gcp60, Pap7
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

IPO7_HUMAN
θ value	1.38821 (rank : 1040)	NC score	0.002157 (rank : 1446)
Query Neighborhood Hits	1311	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	O95373, Q9H177, Q9NTE3	Gene names	IPO7, RANBP7
Domain Architecture
Description	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7).

IRF2_MOUSE
θ value	1.38821 (rank : 1041)	NC score	0.001955 (rank : 1449)
Query Neighborhood Hits	1311	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	P23906	Gene names	Irf2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

K0256_HUMAN
θ value	1.38821 (rank : 1042)	NC score	0.003363 (rank : 1424)
Query Neighborhood Hits	1311	Target Neighborhood Hits	73	Shared Neighborhood Hits	11
SwissProt Accessions	Q93073, Q8N767	Gene names	KIAA0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

LIGA_HUMAN
θ value	1.38821 (rank : 1043)	NC score	0.009408 (rank : 1371)
Query Neighborhood Hits	1311	Target Neighborhood Hits	23	Shared Neighborhood Hits	7
SwissProt Accessions	P41214, Q9NR27, Q9NSN0, Q9NV18, Q9NZ21	Gene names	LGTN, HCA56
Domain Architecture
Description	Ligatin (Hepatocellular carcinoma-associated antigen 56).

NONO_HUMAN
θ value	1.38821 (rank : 1044)	NC score	0.018219 (rank : 1303)
Query Neighborhood Hits	1311	Target Neighborhood Hits	441	Shared Neighborhood Hits	100
SwissProt Accessions	Q15233, O00201, P30807, Q12786, Q9BQC5	Gene names	NONO, NRB54
Domain Architecture
Description	Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit).

OXRP_HUMAN
θ value	1.38821 (rank : 1045)	NC score	0.004530 (rank : 1410)
Query Neighborhood Hits	1311	Target Neighborhood Hits	544	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

RU17_MOUSE
θ value	1.38821 (rank : 1046)	NC score	-0.002898 (rank : 1480)
Query Neighborhood Hits	1311	Target Neighborhood Hits	278	Shared Neighborhood Hits	32
SwissProt Accessions	Q62376, Q3UIW4	Gene names	Snrp70
Domain Architecture	No domain graphic available
Description	U1 small nuclear ribonucleoprotein 70 kDa (U1 SNRNP 70 kDa) (snRNP70).

SIAL_HUMAN
θ value	1.38821 (rank : 1047)	NC score	0.007666 (rank : 1380)
Query Neighborhood Hits	1311	Target Neighborhood Hits	77	Shared Neighborhood Hits	17
SwissProt Accessions	P21815	Gene names	IBSP, BNSP
Domain Architecture
Description	Bone sialoprotein-2 precursor (Bone sialoprotein II) (BSP II) (Cell- binding sialoprotein) (Integrin-binding sialoprotein).

SON_MOUSE
θ value	1.38821 (rank : 1048)	NC score	0.016053 (rank : 1317)
Query Neighborhood Hits	1311	Target Neighborhood Hits	957	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

TRI44_MOUSE
θ value	1.38821 (rank : 1049)	NC score	0.004258 (rank : 1412)
Query Neighborhood Hits	1311	Target Neighborhood Hits	327	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

UBP49_MOUSE
θ value	1.38821 (rank : 1050)	NC score	-0.003612 (rank : 1483)
Query Neighborhood Hits	1311	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9L4	Gene names	Usp49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

AFF1_MOUSE
θ value	1.81305 (rank : 1051)	NC score	0.012029 (rank : 1345)
Query Neighborhood Hits	1311	Target Neighborhood Hits	351	Shared Neighborhood Hits	54
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

AP3B1_MOUSE
θ value	1.81305 (rank : 1052)	NC score	0.002157 (rank : 1447)
Query Neighborhood Hits	1311	Target Neighborhood Hits	302	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

ARI4A_HUMAN
θ value	1.81305 (rank : 1053)	NC score	0.031718 (rank : 1218)
Query Neighborhood Hits	1311	Target Neighborhood Hits	434	Shared Neighborhood Hits	131
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

ATBF1_MOUSE
θ value	1.81305 (rank : 1054)	NC score	-0.016078 (rank : 1497)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1841	Shared Neighborhood Hits	152
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CB013_MOUSE
θ value	1.81305 (rank : 1055)	NC score	0.004229 (rank : 1413)
Query Neighborhood Hits	1311	Target Neighborhood Hits	43	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

CDR2_MOUSE
θ value	1.81305 (rank : 1056)	NC score	0.037794 (rank : 1190)
Query Neighborhood Hits	1311	Target Neighborhood Hits	482	Shared Neighborhood Hits	155
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

CF153_HUMAN
θ value	1.81305 (rank : 1057)	NC score	0.021571 (rank : 1279)
Query Neighborhood Hits	1311	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q96EU6, Q9BRF6, Q9P0C8	Gene names	C6orf153
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf153.

DHX16_HUMAN
θ value	1.81305 (rank : 1058)	NC score	0.016213 (rank : 1316)
Query Neighborhood Hits	1311	Target Neighborhood Hits	356	Shared Neighborhood Hits	130
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

DISC1_MOUSE
θ value	1.81305 (rank : 1059)	NC score	0.004967 (rank : 1404)
Query Neighborhood Hits	1311	Target Neighborhood Hits	133	Shared Neighborhood Hits	32
SwissProt Accessions	Q811T9, Q7TQ21, Q8CF87, Q8CF88, Q8CHP1, Q8CHP2	Gene names	Disc1
Domain Architecture	No domain graphic available
Description	Disrupted in schizophrenia 1 homolog.

DREB_MOUSE
θ value	1.81305 (rank : 1060)	NC score	0.040159 (rank : 1171)
Query Neighborhood Hits	1311	Target Neighborhood Hits	446	Shared Neighborhood Hits	137
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

E41L3_HUMAN
θ value	1.81305 (rank : 1061)	NC score	-0.001934 (rank : 1476)
Query Neighborhood Hits	1311	Target Neighborhood Hits	113	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

ERCC5_MOUSE
θ value	1.81305 (rank : 1062)	NC score	0.019955 (rank : 1292)
Query Neighborhood Hits	1311	Target Neighborhood Hits	206	Shared Neighborhood Hits	61
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

FLIP1_HUMAN
θ value	1.81305 (rank : 1063)	NC score	0.050566 (rank : 1094)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1405	Shared Neighborhood Hits	306
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FYCO1_MOUSE
θ value	1.81305 (rank : 1064)	NC score	0.036218 (rank : 1196)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1059	Shared Neighborhood Hits	226
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

KI21B_HUMAN
θ value	1.81305 (rank : 1065)	NC score	0.016031 (rank : 1318)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1017	Shared Neighborhood Hits	198
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

LEO1_HUMAN
θ value	1.81305 (rank : 1066)	NC score	0.044650 (rank : 1144)
Query Neighborhood Hits	1311	Target Neighborhood Hits	958	Shared Neighborhood Hits	250
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MYH11_HUMAN
θ value	1.81305 (rank : 1067)	NC score	0.045265 (rank : 1139)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1806	Shared Neighborhood Hits	349
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PRP40_MOUSE
θ value	1.81305 (rank : 1068)	NC score	0.023666 (rank : 1267)
Query Neighborhood Hits	1311	Target Neighborhood Hits	447	Shared Neighborhood Hits	130
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

PTPR2_MOUSE
θ value	1.81305 (rank : 1069)	NC score	-0.004436 (rank : 1487)
Query Neighborhood Hits	1311	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

RENT2_HUMAN
θ value	1.81305 (rank : 1070)	NC score	0.038463 (rank : 1183)
Query Neighborhood Hits	1311	Target Neighborhood Hits	618	Shared Neighborhood Hits	169
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

RXINP_HUMAN
θ value	1.81305 (rank : 1071)	NC score	0.014917 (rank : 1325)
Query Neighborhood Hits	1311	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	Q96RL1, Q5XKQ1, Q7Z3W7, Q8N5B9, Q9BZR1, Q9BZR5, Q9UHX7	Gene names	RXRIP110, RAP80
Domain Architecture	No domain graphic available
Description	Retinoid X receptor-interacting protein 110 (Receptor-associated protein 80) (Nuclear zinc finger protein RAP80).

SPT6H_HUMAN
θ value	1.81305 (rank : 1072)	NC score	0.007673 (rank : 1379)
Query Neighborhood Hits	1311	Target Neighborhood Hits	104	Shared Neighborhood Hits	30
SwissProt Accessions	Q7KZ85, Q15737, Q6GMQ4, Q7KYW9, Q7LDK4, Q8N526, Q92775, Q96AH3, Q9BTH9, Q9BTI2	Gene names	SUPT6H, KIAA0162, SPT6H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT6 (hSPT6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein).

TAIP2_HUMAN
θ value	1.81305 (rank : 1073)	NC score	0.002377 (rank : 1440)
Query Neighborhood Hits	1311	Target Neighborhood Hits	37	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WYN3	Gene names	TAIP2
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 2 (TAIP-2).

TUR8_MOUSE
θ value	1.81305 (rank : 1074)	NC score	0.011381 (rank : 1348)
Query Neighborhood Hits	1311	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	P19473	Gene names	Trap1a, P1a
Domain Architecture	No domain graphic available
Description	Tumor rejection antigen P815A.

TXD13_HUMAN
θ value	1.81305 (rank : 1075)	NC score	0.003730 (rank : 1421)
Query Neighborhood Hits	1311	Target Neighborhood Hits	106	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H1E5, Q8N4P7, Q8NCC1, Q9UJA1, Q9ULQ8	Gene names	TXNDC13, KIAA1162
Domain Architecture
Description	Thioredoxin domain-containing protein 13 precursor.

U2AFL_MOUSE
θ value	1.81305 (rank : 1076)	NC score	0.024584 (rank : 1259)
Query Neighborhood Hits	1311	Target Neighborhood Hits	389	Shared Neighborhood Hits	113
SwissProt Accessions	Q64707	Gene names	Zrsr1, Sp2, Sp2-7, U2af1-rs1, U2af1l1
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2).

ABTAP_MOUSE
θ value	2.36792 (rank : 1077)	NC score	0.029884 (rank : 1232)
Query Neighborhood Hits	1311	Target Neighborhood Hits	381	Shared Neighborhood Hits	130
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

ALMS1_HUMAN
θ value	2.36792 (rank : 1078)	NC score	0.010742 (rank : 1354)
Query Neighborhood Hits	1311	Target Neighborhood Hits	356	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

AZI1_HUMAN
θ value	2.36792 (rank : 1079)	NC score	0.060273 (rank : 960)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1000	Shared Neighborhood Hits	237
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

BFSP1_HUMAN
θ value	2.36792 (rank : 1080)	NC score	0.019902 (rank : 1293)
Query Neighborhood Hits	1311	Target Neighborhood Hits	508	Shared Neighborhood Hits	144
SwissProt Accessions	Q12934, O43595, O76034, Q9HBX4	Gene names	BFSP1
Domain Architecture
Description	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H).

CCAR1_MOUSE
θ value	2.36792 (rank : 1081)	NC score	0.027194 (rank : 1245)
Query Neighborhood Hits	1311	Target Neighborhood Hits	414	Shared Neighborhood Hits	135
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

CCD46_MOUSE
θ value	2.36792 (rank : 1082)	NC score	0.063220 (rank : 938)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1405	Shared Neighborhood Hits	314
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CCD96_MOUSE
θ value	2.36792 (rank : 1083)	NC score	0.057041 (rank : 1001)
Query Neighborhood Hits	1311	Target Neighborhood Hits	704	Shared Neighborhood Hits	225
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CDN1C_MOUSE
θ value	2.36792 (rank : 1084)	NC score	0.006420 (rank : 1390)
Query Neighborhood Hits	1311	Target Neighborhood Hits	161	Shared Neighborhood Hits	35
SwissProt Accessions	P49919	Gene names	Cdkn1c, Kip2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

CE110_HUMAN
θ value	2.36792 (rank : 1085)	NC score	0.018147 (rank : 1304)
Query Neighborhood Hits	1311	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

CLSPN_HUMAN
θ value	2.36792 (rank : 1086)	NC score	0.031589 (rank : 1219)
Query Neighborhood Hits	1311	Target Neighborhood Hits	433	Shared Neighborhood Hits	145
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

CT077_HUMAN
θ value	2.36792 (rank : 1087)	NC score	0.010995 (rank : 1350)
Query Neighborhood Hits	1311	Target Neighborhood Hits	155	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NQG5	Gene names	C20orf77
Domain Architecture
Description	Uncharacterized protein C20orf77.

DBNL_MOUSE
θ value	2.36792 (rank : 1088)	NC score	0.021676 (rank : 1278)
Query Neighborhood Hits	1311	Target Neighborhood Hits	306	Shared Neighborhood Hits	75
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

EP300_HUMAN
θ value	2.36792 (rank : 1089)	NC score	0.010444 (rank : 1356)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	99
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

FYV1_HUMAN
θ value	2.36792 (rank : 1090)	NC score	0.003325 (rank : 1425)
Query Neighborhood Hits	1311	Target Neighborhood Hits	217	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

HRX_HUMAN
θ value	2.36792 (rank : 1091)	NC score	0.002732 (rank : 1434)
Query Neighborhood Hits	1311	Target Neighborhood Hits	825	Shared Neighborhood Hits	107
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

IFT81_HUMAN
θ value	2.36792 (rank : 1092)	NC score	0.057359 (rank : 995)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	231
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

MYH9_HUMAN
θ value	2.36792 (rank : 1093)	NC score	0.044948 (rank : 1141)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1762	Shared Neighborhood Hits	343
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYO5C_HUMAN
θ value	2.36792 (rank : 1094)	NC score	0.046472 (rank : 1133)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1206	Shared Neighborhood Hits	293
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

NCKX1_HUMAN
θ value	2.36792 (rank : 1095)	NC score	0.003274 (rank : 1426)
Query Neighborhood Hits	1311	Target Neighborhood Hits	223	Shared Neighborhood Hits	41
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

NCOR1_MOUSE
θ value	2.36792 (rank : 1096)	NC score	0.016743 (rank : 1312)
Query Neighborhood Hits	1311	Target Neighborhood Hits	521	Shared Neighborhood Hits	121
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

NEBL_HUMAN
θ value	2.36792 (rank : 1097)	NC score	0.037960 (rank : 1187)
Query Neighborhood Hits	1311	Target Neighborhood Hits	457	Shared Neighborhood Hits	150
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEST_HUMAN
θ value	2.36792 (rank : 1098)	NC score	0.057976 (rank : 984)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1305	Shared Neighborhood Hits	321
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NFL_MOUSE
θ value	2.36792 (rank : 1099)	NC score	0.013133 (rank : 1337)
Query Neighborhood Hits	1311	Target Neighborhood Hits	695	Shared Neighborhood Hits	187
SwissProt Accessions	P08551, Q8K0Z0	Gene names	Nefl, Nf68, Nfl
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

NOP56_MOUSE
θ value	2.36792 (rank : 1100)	NC score	0.007894 (rank : 1377)
Query Neighborhood Hits	1311	Target Neighborhood Hits	129	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D6Z1, Q3UD45, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15	Gene names	Nol5a, Nop56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

NUMA1_HUMAN
θ value	2.36792 (rank : 1101)	NC score	0.046784 (rank : 1129)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1523	Shared Neighborhood Hits	282
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

PRP40_HUMAN
θ value	2.36792 (rank : 1102)	NC score	0.023611 (rank : 1268)
Query Neighborhood Hits	1311	Target Neighborhood Hits	442	Shared Neighborhood Hits	137
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

REST_MOUSE
θ value	2.36792 (rank : 1103)	NC score	0.047306 (rank : 1124)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1506	Shared Neighborhood Hits	308
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

RN168_HUMAN
θ value	2.36792 (rank : 1104)	NC score	0.002193 (rank : 1444)
Query Neighborhood Hits	1311	Target Neighborhood Hits	370	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN168_MOUSE
θ value	2.36792 (rank : 1105)	NC score	0.011701 (rank : 1347)
Query Neighborhood Hits	1311	Target Neighborhood Hits	440	Shared Neighborhood Hits	91
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RUSC1_HUMAN
θ value	2.36792 (rank : 1106)	NC score	0.017954 (rank : 1307)
Query Neighborhood Hits	1311	Target Neighborhood Hits	226	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RXINP_MOUSE
θ value	2.36792 (rank : 1107)	NC score	0.008293 (rank : 1376)
Query Neighborhood Hits	1311	Target Neighborhood Hits	99	Shared Neighborhood Hits	31
SwissProt Accessions	Q5U5Q9, Q60811	Gene names	Rxrip110, Rip110
Domain Architecture	No domain graphic available
Description	Retinoid X receptor-interacting protein 110.

RYR1_HUMAN
θ value	2.36792 (rank : 1108)	NC score	0.006041 (rank : 1396)
Query Neighborhood Hits	1311	Target Neighborhood Hits	303	Shared Neighborhood Hits	58
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

ST65G_MOUSE
θ value	2.36792 (rank : 1109)	NC score	0.005948 (rank : 1397)
Query Neighborhood Hits	1311	Target Neighborhood Hits	23	Shared Neighborhood Hits	7
SwissProt Accessions	Q9CZV5	Gene names	Supt7l
Domain Architecture
Description	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like).

TCAL3_MOUSE
θ value	2.36792 (rank : 1110)	NC score	0.009638 (rank : 1367)
Query Neighborhood Hits	1311	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R0A5, Q9CYK5, Q9D1S4	Gene names	Tceal3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

TEX9_MOUSE
θ value	2.36792 (rank : 1111)	NC score	0.031752 (rank : 1215)
Query Neighborhood Hits	1311	Target Neighborhood Hits	581	Shared Neighborhood Hits	177
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

TNIP3_HUMAN
θ value	2.36792 (rank : 1112)	NC score	0.046759 (rank : 1130)
Query Neighborhood Hits	1311	Target Neighborhood Hits	511	Shared Neighborhood Hits	161
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

TNNT2_HUMAN
θ value	2.36792 (rank : 1113)	NC score	0.046909 (rank : 1126)
Query Neighborhood Hits	1311	Target Neighborhood Hits	433	Shared Neighborhood Hits	147
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TRM6_MOUSE
θ value	2.36792 (rank : 1114)	NC score	0.005732 (rank : 1399)
Query Neighborhood Hits	1311	Target Neighborhood Hits	39	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CE96, Q3TJZ8, Q3TME7, Q6ZPW8, Q80Y59, Q8CEU0	Gene names	Trm6, Kiaa1153
Domain Architecture	No domain graphic available
Description	tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6).

VDP_HUMAN
θ value	2.36792 (rank : 1115)	NC score	0.032020 (rank : 1213)
Query Neighborhood Hits	1311	Target Neighborhood Hits	645	Shared Neighborhood Hits	161
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

AATF_MOUSE
θ value	3.0926 (rank : 1116)	NC score	0.006105 (rank : 1395)
Query Neighborhood Hits	1311	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JKX4, Q7TQN1, Q8C5Q2, Q99P89	Gene names	Aatf, Che1, Trb
Domain Architecture	No domain graphic available
Description	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) (Traube protein).

ANR26_HUMAN
θ value	3.0926 (rank : 1117)	NC score	0.045408 (rank : 1138)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1614	Shared Neighborhood Hits	322
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

BRD4_MOUSE
θ value	3.0926 (rank : 1118)	NC score	0.018089 (rank : 1306)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	180
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CHD5_HUMAN
θ value	3.0926 (rank : 1119)	NC score	-0.003535 (rank : 1481)
Query Neighborhood Hits	1311	Target Neighborhood Hits	349	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

CJ006_MOUSE
θ value	3.0926 (rank : 1120)	NC score	0.006993 (rank : 1384)
Query Neighborhood Hits	1311	Target Neighborhood Hits	141	Shared Neighborhood Hits	33
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

CK5P2_HUMAN
θ value	3.0926 (rank : 1121)	NC score	0.050987 (rank : 1085)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1433	Shared Neighborhood Hits	324
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

CLGN_HUMAN
θ value	3.0926 (rank : 1122)	NC score	0.000864 (rank : 1460)
Query Neighborhood Hits	1311	Target Neighborhood Hits	111	Shared Neighborhood Hits	35
SwissProt Accessions	O14967	Gene names	CLGN
Domain Architecture
Description	Calmegin precursor.

COBA1_HUMAN
θ value	3.0926 (rank : 1123)	NC score	-0.009739 (rank : 1493)
Query Neighborhood Hits	1311	Target Neighborhood Hits	491	Shared Neighborhood Hits	36
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

CROP_HUMAN
θ value	3.0926 (rank : 1124)	NC score	0.040111 (rank : 1172)
Query Neighborhood Hits	1311	Target Neighborhood Hits	402	Shared Neighborhood Hits	127
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

DHX29_HUMAN
θ value	3.0926 (rank : 1125)	NC score	0.001689 (rank : 1450)
Query Neighborhood Hits	1311	Target Neighborhood Hits	144	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z478, O75549, Q63HN0, Q63HN3, Q8IWW2, Q8N3A1, Q9UMH2	Gene names	DHX29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29) (Nucleic acid helicase DDXx).

DYNA_MOUSE
θ value	3.0926 (rank : 1126)	NC score	0.035772 (rank : 1198)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1084	Shared Neighborhood Hits	239
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

ERC2_HUMAN
θ value	3.0926 (rank : 1127)	NC score	0.041889 (rank : 1159)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1156	Shared Neighborhood Hits	249
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

FOSB_MOUSE
θ value	3.0926 (rank : 1128)	NC score	0.004894 (rank : 1405)
Query Neighborhood Hits	1311	Target Neighborhood Hits	137	Shared Neighborhood Hits	39
SwissProt Accessions	P13346	Gene names	Fosb
Domain Architecture	No domain graphic available
Description	Protein fosB.

FYV1_MOUSE
θ value	3.0926 (rank : 1129)	NC score	0.001433 (rank : 1451)
Query Neighborhood Hits	1311	Target Neighborhood Hits	191	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

HDAC5_HUMAN
θ value	3.0926 (rank : 1130)	NC score	0.014527 (rank : 1327)
Query Neighborhood Hits	1311	Target Neighborhood Hits	353	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

IPF1_HUMAN
θ value	3.0926 (rank : 1131)	NC score	-0.016594 (rank : 1498)
Query Neighborhood Hits	1311	Target Neighborhood Hits	330	Shared Neighborhood Hits	3
SwissProt Accessions	P52945, O60594	Gene names	IPF1, PDX1
Domain Architecture
Description	Insulin promoter factor 1 (IPF-1) (Pancreas/duodenum homeobox 1) (PDX- 1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) (Insulin upstream factor 1) (IUF-1) (Glucose- sensitive factor) (GSF).

KIF14_HUMAN
θ value	3.0926 (rank : 1132)	NC score	0.021187 (rank : 1284)
Query Neighborhood Hits	1311	Target Neighborhood Hits	732	Shared Neighborhood Hits	219
SwissProt Accessions	Q15058	Gene names	KIF14, KIAA0042
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF14.

LAMB1_HUMAN
θ value	3.0926 (rank : 1133)	NC score	0.012454 (rank : 1342)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1018	Shared Neighborhood Hits	191
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

MPP10_HUMAN
θ value	3.0926 (rank : 1134)	NC score	0.023148 (rank : 1270)
Query Neighborhood Hits	1311	Target Neighborhood Hits	306	Shared Neighborhood Hits	110
SwissProt Accessions	O00566	Gene names	MPHOSPH10, MPP10
Domain Architecture
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

NOC2L_MOUSE
θ value	3.0926 (rank : 1135)	NC score	0.004850 (rank : 1406)
Query Neighborhood Hits	1311	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV70, Q8VE16	Gene names	Noc2l
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

OFD1_HUMAN
θ value	3.0926 (rank : 1136)	NC score	0.052782 (rank : 1053)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	197
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

PDXL2_MOUSE
θ value	3.0926 (rank : 1137)	NC score	0.012867 (rank : 1339)
Query Neighborhood Hits	1311	Target Neighborhood Hits	213	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

PERQ1_MOUSE
θ value	3.0926 (rank : 1138)	NC score	0.026985 (rank : 1247)
Query Neighborhood Hits	1311	Target Neighborhood Hits	215	Shared Neighborhood Hits	73
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

RABE1_MOUSE
θ value	3.0926 (rank : 1139)	NC score	0.050649 (rank : 1091)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1105	Shared Neighborhood Hits	265
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

RBBP6_HUMAN
θ value	3.0926 (rank : 1140)	NC score	0.031748 (rank : 1216)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1135	Shared Neighborhood Hits	231
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RPGR_HUMAN
θ value	3.0926 (rank : 1141)	NC score	0.049227 (rank : 1111)
Query Neighborhood Hits	1311	Target Neighborhood Hits	279	Shared Neighborhood Hits	108
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

RTN2_MOUSE
θ value	3.0926 (rank : 1142)	NC score	0.001173 (rank : 1455)
Query Neighborhood Hits	1311	Target Neighborhood Hits	48	Shared Neighborhood Hits	11
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

SFR12_HUMAN
θ value	3.0926 (rank : 1143)	NC score	0.044491 (rank : 1147)
Query Neighborhood Hits	1311	Target Neighborhood Hits	553	Shared Neighborhood Hits	141
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

SH3BG_MOUSE
θ value	3.0926 (rank : 1144)	NC score	0.003139 (rank : 1428)
Query Neighborhood Hits	1311	Target Neighborhood Hits	99	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WUZ7	Gene names	Sh3bgr
Domain Architecture
Description	SH3 domain-binding glutamic acid-rich protein (SH3BGR protein).

SMCE1_HUMAN
θ value	3.0926 (rank : 1145)	NC score	0.006463 (rank : 1388)
Query Neighborhood Hits	1311	Target Neighborhood Hits	272	Shared Neighborhood Hits	74
SwissProt Accessions	Q969G3, O43539	Gene names	SMARCE1, BAF57
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57).

SRPR_HUMAN
θ value	3.0926 (rank : 1146)	NC score	0.002586 (rank : 1436)
Query Neighborhood Hits	1311	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	P08240, Q9BVJ4	Gene names	SRPR
Domain Architecture
Description	Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha).

STK23_MOUSE
θ value	3.0926 (rank : 1147)	NC score	0.554937 (rank : 823)
Query Neighborhood Hits	1311	Target Neighborhood Hits	572	Shared Neighborhood Hits	558
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

TCAL5_MOUSE
θ value	3.0926 (rank : 1148)	NC score	0.006402 (rank : 1391)
Query Neighborhood Hits	1311	Target Neighborhood Hits	63	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CCT4, Q497R6	Gene names	Tceal5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

TE2IP_MOUSE
θ value	3.0926 (rank : 1149)	NC score	0.002821 (rank : 1432)
Query Neighborhood Hits	1311	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	Q91VL8, Q543F4, Q9JJE8, Q9JJE9	Gene names	Terf2ip, Rap1
Domain Architecture	No domain graphic available
Description	Telomeric repeat-binding factor 2-interacting protein 1 (TRF2- interacting telomeric protein Rap1).

TF2AY_HUMAN
θ value	3.0926 (rank : 1150)	NC score	0.016240 (rank : 1315)
Query Neighborhood Hits	1311	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNN4	Gene names	GTF2A1LF, ALF
Domain Architecture
Description	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor).

TP53B_MOUSE
θ value	3.0926 (rank : 1151)	NC score	0.031110 (rank : 1222)
Query Neighborhood Hits	1311	Target Neighborhood Hits	644	Shared Neighborhood Hits	154
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

UACA_MOUSE
θ value	3.0926 (rank : 1152)	NC score	0.044525 (rank : 1146)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1620	Shared Neighborhood Hits	312
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

WRN_MOUSE
θ value	3.0926 (rank : 1153)	NC score	0.007515 (rank : 1381)
Query Neighborhood Hits	1311	Target Neighborhood Hits	295	Shared Neighborhood Hits	85
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

3BP5_HUMAN
θ value	4.03905 (rank : 1154)	NC score	0.030304 (rank : 1229)
Query Neighborhood Hits	1311	Target Neighborhood Hits	375	Shared Neighborhood Hits	120
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

ACINU_MOUSE
θ value	4.03905 (rank : 1155)	NC score	0.044944 (rank : 1142)
Query Neighborhood Hits	1311	Target Neighborhood Hits	712	Shared Neighborhood Hits	200
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

AN32E_HUMAN
θ value	4.03905 (rank : 1156)	NC score	0.004359 (rank : 1411)
Query Neighborhood Hits	1311	Target Neighborhood Hits	291	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

APLP2_MOUSE
θ value	4.03905 (rank : 1157)	NC score	0.018134 (rank : 1305)
Query Neighborhood Hits	1311	Target Neighborhood Hits	186	Shared Neighborhood Hits	80
SwissProt Accessions	Q06335	Gene names	Aplp2
Domain Architecture
Description	Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP).

CDR2_HUMAN
θ value	4.03905 (rank : 1158)	NC score	0.027215 (rank : 1244)
Query Neighborhood Hits	1311	Target Neighborhood Hits	404	Shared Neighborhood Hits	127
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

CSTN1_MOUSE
θ value	4.03905 (rank : 1159)	NC score	-0.006791 (rank : 1492)
Query Neighborhood Hits	1311	Target Neighborhood Hits	175	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EPL2	Gene names	Clstn1, Cs1, Cstn1
Domain Architecture
Description	Calsyntenin-1 precursor.

CT2NL_HUMAN
θ value	4.03905 (rank : 1160)	NC score	0.052098 (rank : 1062)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1059	Shared Neighborhood Hits	288
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

HOOK3_MOUSE
θ value	4.03905 (rank : 1161)	NC score	0.037508 (rank : 1191)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1007	Shared Neighborhood Hits	230
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

ICAL_HUMAN
θ value	4.03905 (rank : 1162)	NC score	0.009447 (rank : 1370)
Query Neighborhood Hits	1311	Target Neighborhood Hits	275	Shared Neighborhood Hits	67
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

K0319_MOUSE
θ value	4.03905 (rank : 1163)	NC score	0.003668 (rank : 1422)
Query Neighborhood Hits	1311	Target Neighborhood Hits	134	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SZV5, Q80U39	Gene names	Kiaa0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

LEO1_MOUSE
θ value	4.03905 (rank : 1164)	NC score	0.038871 (rank : 1180)
Query Neighborhood Hits	1311	Target Neighborhood Hits	946	Shared Neighborhood Hits	247
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

LIPB1_MOUSE
θ value	4.03905 (rank : 1165)	NC score	0.029159 (rank : 1236)
Query Neighborhood Hits	1311	Target Neighborhood Hits	727	Shared Neighborhood Hits	196
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

LMNB2_MOUSE
θ value	4.03905 (rank : 1166)	NC score	0.020052 (rank : 1291)
Query Neighborhood Hits	1311	Target Neighborhood Hits	674	Shared Neighborhood Hits	181
SwissProt Accessions	P21619, P48680, Q8CGB1	Gene names	Lmnb2
Domain Architecture
Description	Lamin-B2.

MAP9_HUMAN
θ value	4.03905 (rank : 1167)	NC score	0.043686 (rank : 1152)
Query Neighborhood Hits	1311	Target Neighborhood Hits	518	Shared Neighborhood Hits	159
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

NOG2_MOUSE
θ value	4.03905 (rank : 1168)	NC score	0.002987 (rank : 1431)
Query Neighborhood Hits	1311	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	Q99LH1, Q8BIF8	Gene names	Gnl2
Domain Architecture	No domain graphic available
Description	Nucleolar GTP-binding protein 2.

NOLC1_HUMAN
θ value	4.03905 (rank : 1169)	NC score	0.017462 (rank : 1311)
Query Neighborhood Hits	1311	Target Neighborhood Hits	452	Shared Neighborhood Hits	74
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NSBP1_MOUSE
θ value	4.03905 (rank : 1170)	NC score	0.032770 (rank : 1210)
Query Neighborhood Hits	1311	Target Neighborhood Hits	681	Shared Neighborhood Hits	201
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

NUCL_HUMAN
θ value	4.03905 (rank : 1171)	NC score	-0.002774 (rank : 1479)
Query Neighborhood Hits	1311	Target Neighborhood Hits	415	Shared Neighborhood Hits	55
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

PHLB1_HUMAN
θ value	4.03905 (rank : 1172)	NC score	0.038463 (rank : 1184)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1038	Shared Neighborhood Hits	225
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PLCB1_HUMAN
θ value	4.03905 (rank : 1173)	NC score	0.034855 (rank : 1203)
Query Neighborhood Hits	1311	Target Neighborhood Hits	614	Shared Neighborhood Hits	184
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

RBM25_HUMAN
θ value	4.03905 (rank : 1174)	NC score	0.061677 (rank : 954)
Query Neighborhood Hits	1311	Target Neighborhood Hits	682	Shared Neighborhood Hits	178
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

REN3A_HUMAN
θ value	4.03905 (rank : 1175)	NC score	0.031745 (rank : 1217)
Query Neighborhood Hits	1311	Target Neighborhood Hits	248	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H1J1, Q5T8C3, Q5T8C9, Q7Z6N3, Q86YK1, Q9BZI8	Gene names	UPF3A, RENT3A, UPF3
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3).

RPGF6_HUMAN
θ value	4.03905 (rank : 1176)	NC score	-0.001000 (rank : 1468)
Query Neighborhood Hits	1311	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

SCN1A_HUMAN
θ value	4.03905 (rank : 1177)	NC score	-0.003537 (rank : 1482)
Query Neighborhood Hits	1311	Target Neighborhood Hits	148	Shared Neighborhood Hits	31
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SET1A_HUMAN
θ value	4.03905 (rank : 1178)	NC score	0.013874 (rank : 1330)
Query Neighborhood Hits	1311	Target Neighborhood Hits	690	Shared Neighborhood Hits	101
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SM1L2_MOUSE
θ value	4.03905 (rank : 1179)	NC score	0.048223 (rank : 1118)
Query Neighborhood Hits	1311	Target Neighborhood Hits	918	Shared Neighborhood Hits	236
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

SPTN5_HUMAN
θ value	4.03905 (rank : 1180)	NC score	0.017756 (rank : 1309)
Query Neighborhood Hits	1311	Target Neighborhood Hits	674	Shared Neighborhood Hits	159
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

ST65G_HUMAN
θ value	4.03905 (rank : 1181)	NC score	0.005298 (rank : 1402)
Query Neighborhood Hits	1311	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	O94864, Q6IB21, Q9H2T6	Gene names	SUPT7L, KIAA0764
Domain Architecture
Description	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1).

T2FA_HUMAN
θ value	4.03905 (rank : 1182)	NC score	0.009577 (rank : 1368)
Query Neighborhood Hits	1311	Target Neighborhood Hits	228	Shared Neighborhood Hits	54
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

TF2AA_HUMAN
θ value	4.03905 (rank : 1183)	NC score	0.006151 (rank : 1394)
Query Neighborhood Hits	1311	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	P52655	Gene names	GTF2A1, TF2A1
Domain Architecture
Description	Transcription initiation factor IIA subunit 1 (General transcription factor IIA1) (TFIIA-42) (TFIIAL) [Contains: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)].

TF2AY_MOUSE
θ value	4.03905 (rank : 1184)	NC score	0.009930 (rank : 1364)
Query Neighborhood Hits	1311	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R4I4, Q99PM2, Q9DAF4	Gene names	Gtf2a1lf, Alf
Domain Architecture
Description	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor).

UBF1_HUMAN
θ value	4.03905 (rank : 1185)	NC score	0.012624 (rank : 1341)
Query Neighborhood Hits	1311	Target Neighborhood Hits	415	Shared Neighborhood Hits	103
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

APLP2_HUMAN
θ value	5.27518 (rank : 1186)	NC score	0.012785 (rank : 1340)
Query Neighborhood Hits	1311	Target Neighborhood Hits	193	Shared Neighborhood Hits	77
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

ARHGC_MOUSE
θ value	5.27518 (rank : 1187)	NC score	0.003925 (rank : 1417)
Query Neighborhood Hits	1311	Target Neighborhood Hits	344	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

BRD3_MOUSE
θ value	5.27518 (rank : 1188)	NC score	0.013284 (rank : 1332)
Query Neighborhood Hits	1311	Target Neighborhood Hits	402	Shared Neighborhood Hits	117
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

CCAR1_HUMAN
θ value	5.27518 (rank : 1189)	NC score	0.027984 (rank : 1241)
Query Neighborhood Hits	1311	Target Neighborhood Hits	444	Shared Neighborhood Hits	135
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

CCD46_HUMAN
θ value	5.27518 (rank : 1190)	NC score	0.062502 (rank : 943)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1430	Shared Neighborhood Hits	314
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CCNB3_MOUSE
θ value	5.27518 (rank : 1191)	NC score	0.003921 (rank : 1418)
Query Neighborhood Hits	1311	Target Neighborhood Hits	211	Shared Neighborhood Hits	58
SwissProt Accessions	Q810T2, Q810T3, Q8VDC8	Gene names	Ccnb3, Cycb3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

CENPF_HUMAN
θ value	5.27518 (rank : 1192)	NC score	0.048263 (rank : 1117)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1932	Shared Neighborhood Hits	340
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CHD1_HUMAN
θ value	5.27518 (rank : 1193)	NC score	-0.000065 (rank : 1463)
Query Neighborhood Hits	1311	Target Neighborhood Hits	337	Shared Neighborhood Hits	62
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

CHD9_MOUSE
θ value	5.27518 (rank : 1194)	NC score	0.003959 (rank : 1416)
Query Neighborhood Hits	1311	Target Neighborhood Hits	427	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

CLUA1_MOUSE
θ value	5.27518 (rank : 1195)	NC score	0.029351 (rank : 1235)
Query Neighborhood Hits	1311	Target Neighborhood Hits	261	Shared Neighborhood Hits	96
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

CN037_MOUSE
θ value	5.27518 (rank : 1196)	NC score	0.004773 (rank : 1407)
Query Neighborhood Hits	1311	Target Neighborhood Hits	179	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BT18, Q8BFQ7, Q8R1Q5, Q9D6C5	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf37 homolog precursor.

CN145_MOUSE
θ value	5.27518 (rank : 1197)	NC score	0.047456 (rank : 1121)
Query Neighborhood Hits	1311	Target Neighborhood Hits	916	Shared Neighborhood Hits	226
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

CND1_HUMAN
θ value	5.27518 (rank : 1198)	NC score	0.002671 (rank : 1435)
Query Neighborhood Hits	1311	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q15021, Q8N6U3	Gene names	NCAPD2, CAPD2, CNAP1, KIAA0159
Domain Architecture
Description	Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (XCAP-D2 homolog).

CROCC_HUMAN
θ value	5.27518 (rank : 1199)	NC score	0.050191 (rank : 1102)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1409	Shared Neighborhood Hits	277
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CT2NL_MOUSE
θ value	5.27518 (rank : 1200)	NC score	0.052038 (rank : 1064)
Query Neighborhood Hits	1311	Target Neighborhood Hits	902	Shared Neighborhood Hits	272
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

DHX9_HUMAN
θ value	5.27518 (rank : 1201)	NC score	-0.000867 (rank : 1467)
Query Neighborhood Hits	1311	Target Neighborhood Hits	62	Shared Neighborhood Hits	10
SwissProt Accessions	Q08211, Q5VY62, Q6PD69, Q99556	Gene names	DHX9, DDX9, NDH2
Domain Architecture
Description	ATP-dependent RNA helicase A (EC 3.6.1.-) (Nuclear DNA helicase II) (NDH II) (DEAH box protein 9).

DPOE3_HUMAN
θ value	5.27518 (rank : 1202)	NC score	0.002564 (rank : 1437)
Query Neighborhood Hits	1311	Target Neighborhood Hits	54	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRF9, Q5W0U1, Q8N758, Q8NCE5, Q9NR32	Gene names	POLE3, CHRAC17
Domain Architecture
Description	DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) (Chromatin accessibility complex 17) (HuCHRAC17) (CHRAC-17) (Arsenic- transactivated protein) (AsTP).

HDAC5_MOUSE
θ value	5.27518 (rank : 1203)	NC score	0.010224 (rank : 1361)
Query Neighborhood Hits	1311	Target Neighborhood Hits	310	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

HMMR_HUMAN
θ value	5.27518 (rank : 1204)	NC score	0.045639 (rank : 1136)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1082	Shared Neighborhood Hits	238
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

K0562_HUMAN
θ value	5.27518 (rank : 1205)	NC score	0.005519 (rank : 1400)
Query Neighborhood Hits	1311	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	O60308, Q5JSQ3, Q5SR24, Q5SR25, Q6PKF5, Q86W32, Q86X14	Gene names	KIAA0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

KBTB6_HUMAN
θ value	5.27518 (rank : 1206)	NC score	-0.011129 (rank : 1495)
Query Neighborhood Hits	1311	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q86V97, Q8N8L0, Q8NDM5, Q96MP6	Gene names	KBTBD6
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 6.

MD1L1_MOUSE
θ value	5.27518 (rank : 1207)	NC score	0.054203 (rank : 1040)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1001	Shared Neighborhood Hits	245
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MOES_MOUSE
θ value	5.27518 (rank : 1208)	NC score	0.030961 (rank : 1223)
Query Neighborhood Hits	1311	Target Neighborhood Hits	923	Shared Neighborhood Hits	213
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

N4BP3_HUMAN
θ value	5.27518 (rank : 1209)	NC score	0.015074 (rank : 1324)
Query Neighborhood Hits	1311	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	O15049, Q7Z6I3	Gene names	N4BP3, KIAA0341
Domain Architecture
Description	NEDD4-binding protein 3 (N4BP3).

NAF1_MOUSE
θ value	5.27518 (rank : 1210)	NC score	0.046499 (rank : 1132)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	232
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

NUF2_HUMAN
θ value	5.27518 (rank : 1211)	NC score	0.038225 (rank : 1185)
Query Neighborhood Hits	1311	Target Neighborhood Hits	661	Shared Neighborhood Hits	180
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

OSBL6_HUMAN
θ value	5.27518 (rank : 1212)	NC score	-0.001102 (rank : 1470)
Query Neighborhood Hits	1311	Target Neighborhood Hits	101	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

PXK_MOUSE
θ value	5.27518 (rank : 1213)	NC score	0.193437 (rank : 849)
Query Neighborhood Hits	1311	Target Neighborhood Hits	320	Shared Neighborhood Hits	215
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RN146_HUMAN
θ value	5.27518 (rank : 1214)	NC score	-0.004289 (rank : 1486)
Query Neighborhood Hits	1311	Target Neighborhood Hits	162	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

SAFB1_HUMAN
θ value	5.27518 (rank : 1215)	NC score	0.020963 (rank : 1285)
Query Neighborhood Hits	1311	Target Neighborhood Hits	493	Shared Neighborhood Hits	124
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

SMC4_MOUSE
θ value	5.27518 (rank : 1216)	NC score	0.037038 (rank : 1194)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	185
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

SPRL1_HUMAN
θ value	5.27518 (rank : 1217)	NC score	0.004557 (rank : 1409)
Query Neighborhood Hits	1311	Target Neighborhood Hits	231	Shared Neighborhood Hits	52
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

SPT16_HUMAN
θ value	5.27518 (rank : 1218)	NC score	0.007322 (rank : 1383)
Query Neighborhood Hits	1311	Target Neighborhood Hits	100	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5B9, Q6GMT8, Q6P2F1, Q6PJM1, Q9NRX0	Gene names	SUPT16H, FACT140, FACTP140
Domain Architecture	No domain graphic available
Description	FACT complex subunit SPT16 (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) (FACT 140 kDa subunit) (FACTp140) (Chromatin-specific transcription elongation factor 140 kDa subunit).

SPT16_MOUSE
θ value	5.27518 (rank : 1219)	NC score	0.006554 (rank : 1385)
Query Neighborhood Hits	1311	Target Neighborhood Hits	91	Shared Neighborhood Hits	35
SwissProt Accessions	Q920B9, Q3TZ48, Q3UFH0, Q921H4	Gene names	Supt16h, Fact140, Factp140
Domain Architecture	No domain graphic available
Description	FACT complex subunit SPT16 (Facilitates chromatin transcription complex subunit SPT16) (FACT 140 kDa subunit) (FACTp140) (Chromatin- specific transcription elongation factor 140 kDa subunit).

SPT5H_MOUSE
θ value	5.27518 (rank : 1220)	NC score	0.005875 (rank : 1398)
Query Neighborhood Hits	1311	Target Neighborhood Hits	437	Shared Neighborhood Hits	62
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

UACA_HUMAN
θ value	5.27518 (rank : 1221)	NC score	0.039559 (rank : 1176)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1622	Shared Neighborhood Hits	296
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

A16L1_HUMAN
θ value	6.88961 (rank : 1222)	NC score	0.000997 (rank : 1457)
Query Neighborhood Hits	1311	Target Neighborhood Hits	664	Shared Neighborhood Hits	131
SwissProt Accessions	Q676U5, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619	Gene names	ATG16L1, APG16L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

AN13A_MOUSE
θ value	6.88961 (rank : 1223)	NC score	0.002793 (rank : 1433)
Query Neighborhood Hits	1311	Target Neighborhood Hits	226	Shared Neighborhood Hits	25
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

AN32C_HUMAN
θ value	6.88961 (rank : 1224)	NC score	0.004752 (rank : 1408)
Query Neighborhood Hits	1311	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	O43423	Gene names	ANP32C, PP32R1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member C (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1).

AN32E_MOUSE
θ value	6.88961 (rank : 1225)	NC score	0.002268 (rank : 1442)
Query Neighborhood Hits	1311	Target Neighborhood Hits	257	Shared Neighborhood Hits	32
SwissProt Accessions	P97822, Q3TH89, Q8BPF8, Q8C2L4, Q8C7Q8, Q9CZD2	Gene names	Anp32e, Cpd1
Domain Architecture
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L) (Cerebellar postnatal development protein 1).

AR13B_MOUSE
θ value	6.88961 (rank : 1226)	NC score	-0.005329 (rank : 1491)
Query Neighborhood Hits	1311	Target Neighborhood Hits	245	Shared Neighborhood Hits	26
SwissProt Accessions	Q640N2	Gene names	Arl13b, Arl2l1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

ATX3_HUMAN
θ value	6.88961 (rank : 1227)	NC score	0.013784 (rank : 1331)
Query Neighborhood Hits	1311	Target Neighborhood Hits	117	Shared Neighborhood Hits	45
SwissProt Accessions	P54252, O15284, O15285, O15286, Q8N189, Q96TC3, Q96TC4, Q9H3N0	Gene names	ATXN3, ATX3, MJD, MJD1, SCA3
Domain Architecture
Description	Ataxin-3 (EC 3.4.22.-) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein).

B4GN3_HUMAN
θ value	6.88961 (rank : 1228)	NC score	-0.001430 (rank : 1473)
Query Neighborhood Hits	1311	Target Neighborhood Hits	128	Shared Neighborhood Hits	12
SwissProt Accessions	Q6L9W6, Q6ZNC1, Q8N7T6	Gene names	B4GALNT3
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.244) (NGalNAc-T2) (Beta- 1,4-N-acetylgalactosaminyltransferase III) (Beta4GalNAc-T3) (Beta4GalNAcT3).

BAT2_MOUSE
θ value	6.88961 (rank : 1229)	NC score	0.010299 (rank : 1359)
Query Neighborhood Hits	1311	Target Neighborhood Hits	947	Shared Neighborhood Hits	102
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

BAZ1B_HUMAN
θ value	6.88961 (rank : 1230)	NC score	0.030675 (rank : 1225)
Query Neighborhood Hits	1311	Target Neighborhood Hits	701	Shared Neighborhood Hits	216
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

CCD91_HUMAN
θ value	6.88961 (rank : 1231)	NC score	0.061496 (rank : 955)
Query Neighborhood Hits	1311	Target Neighborhood Hits	868	Shared Neighborhood Hits	274
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

DAXX_MOUSE
θ value	6.88961 (rank : 1232)	NC score	0.009076 (rank : 1372)
Query Neighborhood Hits	1311	Target Neighborhood Hits	173	Shared Neighborhood Hits	38
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

DNMT1_HUMAN
θ value	6.88961 (rank : 1233)	NC score	0.020358 (rank : 1288)
Query Neighborhood Hits	1311	Target Neighborhood Hits	401	Shared Neighborhood Hits	121
SwissProt Accessions	P26358, Q9UHG5, Q9ULA2, Q9UMZ6	Gene names	DNMT1, AIM, DNMT
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).

DYNA_HUMAN
θ value	6.88961 (rank : 1234)	NC score	0.037241 (rank : 1192)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1194	Shared Neighborhood Hits	264
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

EDD1_HUMAN
θ value	6.88961 (rank : 1235)	NC score	-0.001052 (rank : 1469)
Query Neighborhood Hits	1311	Target Neighborhood Hits	170	Shared Neighborhood Hits	24
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

G3BP_HUMAN
θ value	6.88961 (rank : 1236)	NC score	-0.001854 (rank : 1475)
Query Neighborhood Hits	1311	Target Neighborhood Hits	219	Shared Neighborhood Hits	29
SwissProt Accessions	Q13283	Gene names	G3BP, G3BP1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

HIP1R_HUMAN
θ value	6.88961 (rank : 1237)	NC score	0.037846 (rank : 1189)
Query Neighborhood Hits	1311	Target Neighborhood Hits	809	Shared Neighborhood Hits	220
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

KI21A_HUMAN
θ value	6.88961 (rank : 1238)	NC score	0.026811 (rank : 1248)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1543	Shared Neighborhood Hits	307
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

KTN1_HUMAN
θ value	6.88961 (rank : 1239)	NC score	0.043695 (rank : 1151)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1197	Shared Neighborhood Hits	245
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

MOES_HUMAN
θ value	6.88961 (rank : 1240)	NC score	0.030417 (rank : 1227)
Query Neighborhood Hits	1311	Target Neighborhood Hits	892	Shared Neighborhood Hits	212
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYO6_MOUSE
θ value	6.88961 (rank : 1241)	NC score	0.031124 (rank : 1220)
Query Neighborhood Hits	1311	Target Neighborhood Hits	586	Shared Neighborhood Hits	166
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

NBR1_HUMAN
θ value	6.88961 (rank : 1242)	NC score	0.002263 (rank : 1443)
Query Neighborhood Hits	1311	Target Neighborhood Hits	105	Shared Neighborhood Hits	22
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

NEB1_HUMAN
θ value	6.88961 (rank : 1243)	NC score	0.025561 (rank : 1255)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	213
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NIN_HUMAN
θ value	6.88961 (rank : 1244)	NC score	0.049623 (rank : 1108)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1416	Shared Neighborhood Hits	296
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

PLCB1_MOUSE
θ value	6.88961 (rank : 1245)	NC score	0.029647 (rank : 1234)
Query Neighborhood Hits	1311	Target Neighborhood Hits	531	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB2_HUMAN
θ value	6.88961 (rank : 1246)	NC score	0.030167 (rank : 1231)
Query Neighborhood Hits	1311	Target Neighborhood Hits	608	Shared Neighborhood Hits	203
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

RABE2_HUMAN
θ value	6.88961 (rank : 1247)	NC score	0.033917 (rank : 1206)
Query Neighborhood Hits	1311	Target Neighborhood Hits	545	Shared Neighborhood Hits	173
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RU17_HUMAN
θ value	6.88961 (rank : 1248)	NC score	-0.004256 (rank : 1485)
Query Neighborhood Hits	1311	Target Neighborhood Hits	280	Shared Neighborhood Hits	38
SwissProt Accessions	P08621, P78493, P78494, Q15364, Q15686, Q15687, Q15689, Q99377, Q9UE45, Q9UE46, Q9UE47, Q9UE48, Q9UFQ6	Gene names	SNRP70, RPU1, U1AP1
Domain Architecture
Description	U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (snRNP70) (U1-70K).

RUFY2_HUMAN
θ value	6.88961 (rank : 1249)	NC score	0.034573 (rank : 1204)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1208	Shared Neighborhood Hits	261
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

SAKS1_HUMAN
θ value	6.88961 (rank : 1250)	NC score	0.016500 (rank : 1313)
Query Neighborhood Hits	1311	Target Neighborhood Hits	202	Shared Neighborhood Hits	69
SwissProt Accessions	Q04323, Q9BV93, Q9BVV5	Gene names	SAKS1
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein).

SH3G2_HUMAN
θ value	6.88961 (rank : 1251)	NC score	0.026048 (rank : 1252)
Query Neighborhood Hits	1311	Target Neighborhood Hits	324	Shared Neighborhood Hits	78
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SM1L2_HUMAN
θ value	6.88961 (rank : 1252)	NC score	0.053458 (rank : 1047)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1019	Shared Neighborhood Hits	267
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SMC2_HUMAN
θ value	6.88961 (rank : 1253)	NC score	0.048464 (rank : 1116)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1405	Shared Neighborhood Hits	320
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SRCA_HUMAN
θ value	6.88961 (rank : 1254)	NC score	0.005391 (rank : 1401)
Query Neighborhood Hits	1311	Target Neighborhood Hits	380	Shared Neighborhood Hits	73
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

STABP_HUMAN
θ value	6.88961 (rank : 1255)	NC score	0.010176 (rank : 1362)
Query Neighborhood Hits	1311	Target Neighborhood Hits	140	Shared Neighborhood Hits	51
SwissProt Accessions	O95630, Q3MJE7	Gene names	STAMBP, AMSH
Domain Architecture	No domain graphic available
Description	STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3 domain of STAM).

SYCP1_MOUSE
θ value	6.88961 (rank : 1256)	NC score	0.047212 (rank : 1125)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1456	Shared Neighborhood Hits	312
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

ZBED3_HUMAN
θ value	6.88961 (rank : 1257)	NC score	0.012008 (rank : 1346)
Query Neighborhood Hits	1311	Target Neighborhood Hits	50	Shared Neighborhood Hits	21
SwissProt Accessions	Q96IU2	Gene names	ZBED3
Domain Architecture
Description	Zinc finger BED domain-containing protein 3.

ZNF96_HUMAN
θ value	6.88961 (rank : 1258)	NC score	-0.026164 (rank : 1501)
Query Neighborhood Hits	1311	Target Neighborhood Hits	869	Shared Neighborhood Hits	48
SwissProt Accessions	O43309, O43724	Gene names	ZNF96, KIAA0426, ZNF305, ZSCAN12
Domain Architecture
Description	Zinc finger protein 96 (Zinc finger protein 305) (Zinc finger and SCAN domain-containing protein 12).

ZO1_HUMAN
θ value	6.88961 (rank : 1259)	NC score	-0.000365 (rank : 1465)
Query Neighborhood Hits	1311	Target Neighborhood Hits	474	Shared Neighborhood Hits	56
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ANK1_MOUSE
θ value	8.99809 (rank : 1260)	NC score	0.010310 (rank : 1358)
Query Neighborhood Hits	1311	Target Neighborhood Hits	430	Shared Neighborhood Hits	60
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANR26_MOUSE
θ value	8.99809 (rank : 1261)	NC score	0.047667 (rank : 1119)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1554	Shared Neighborhood Hits	308
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ATR_HUMAN
θ value	8.99809 (rank : 1262)	NC score	-0.001659 (rank : 1474)
Query Neighborhood Hits	1311	Target Neighborhood Hits	71	Shared Neighborhood Hits	13
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

BCCIP_MOUSE
θ value	8.99809 (rank : 1263)	NC score	0.001068 (rank : 1456)
Query Neighborhood Hits	1311	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CWI3, Q9D1E0	Gene names	Bccip
Domain Architecture	No domain graphic available
Description	BRCA2 and CDKN1A-interacting protein.

CEND3_MOUSE
θ value	8.99809 (rank : 1264)	NC score	0.010049 (rank : 1363)
Query Neighborhood Hits	1311	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CING_MOUSE
θ value	8.99809 (rank : 1265)	NC score	0.057389 (rank : 994)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1432	Shared Neighborhood Hits	315
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

CROP_MOUSE
θ value	8.99809 (rank : 1266)	NC score	0.037103 (rank : 1193)
Query Neighborhood Hits	1311	Target Neighborhood Hits	403	Shared Neighborhood Hits	124
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

CS029_HUMAN
θ value	8.99809 (rank : 1267)	NC score	0.035716 (rank : 1199)
Query Neighborhood Hits	1311	Target Neighborhood Hits	329	Shared Neighborhood Hits	146
SwissProt Accessions	Q8WUQ7, O75229, Q7LE08, Q9BTA6, Q9Y5A4	Gene names	C19orf29
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf29 (NY-REN-24 antigen).

CSPG2_HUMAN
θ value	8.99809 (rank : 1268)	NC score	-0.014351 (rank : 1496)
Query Neighborhood Hits	1311	Target Neighborhood Hits	681	Shared Neighborhood Hits	37
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

DAAM1_HUMAN
θ value	8.99809 (rank : 1269)	NC score	0.015466 (rank : 1322)
Query Neighborhood Hits	1311	Target Neighborhood Hits	483	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y4D1, Q86U34, Q8N1Z8, Q8TB39	Gene names	DAAM1, KIAA0666
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

DC1I1_HUMAN
θ value	8.99809 (rank : 1270)	NC score	-0.001348 (rank : 1472)
Query Neighborhood Hits	1311	Target Neighborhood Hits	183	Shared Neighborhood Hits	28
SwissProt Accessions	O14576, Q9Y2X1	Gene names	DYNC1I1, DNCI1, DNCIC1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

EEA1_MOUSE
θ value	8.99809 (rank : 1271)	NC score	0.041346 (rank : 1160)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1637	Shared Neighborhood Hits	319
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EHMT2_MOUSE
θ value	8.99809 (rank : 1272)	NC score	0.006450 (rank : 1389)
Query Neighborhood Hits	1311	Target Neighborhood Hits	750	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EP15_MOUSE
θ value	8.99809 (rank : 1273)	NC score	0.026759 (rank : 1249)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	176
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

ERC2_MOUSE
θ value	8.99809 (rank : 1274)	NC score	0.044575 (rank : 1145)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1166	Shared Neighborhood Hits	257
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

FOSB_HUMAN
θ value	8.99809 (rank : 1275)	NC score	0.001988 (rank : 1448)
Query Neighborhood Hits	1311	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	P53539	Gene names	FOSB, G0S3
Domain Architecture	No domain graphic available
Description	Protein fosB (G0/G1 switch regulatory protein 3).

HIP1R_MOUSE
θ value	8.99809 (rank : 1276)	NC score	0.049335 (rank : 1109)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	258
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

JADE1_MOUSE
θ value	8.99809 (rank : 1277)	NC score	-0.002271 (rank : 1477)
Query Neighborhood Hits	1311	Target Neighborhood Hits	160	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZPI0, Q6IE84, Q8C7S6, Q8CFM2, Q8R362	Gene names	Phf17, Jade1, Kiaa1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

K0323_MOUSE
θ value	8.99809 (rank : 1278)	NC score	0.000517 (rank : 1461)
Query Neighborhood Hits	1311	Target Neighborhood Hits	33	Shared Neighborhood Hits	7
SwissProt Accessions	Q80U38, Q8BGJ6, Q8C082	Gene names	Kiaa0323
Domain Architecture	No domain graphic available
Description	Protein KIAA0323.

K1C19_MOUSE
θ value	8.99809 (rank : 1279)	NC score	0.002506 (rank : 1439)
Query Neighborhood Hits	1311	Target Neighborhood Hits	358	Shared Neighborhood Hits	109
SwissProt Accessions	P19001	Gene names	Krt19, Krt1-19
Domain Architecture
Description	Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19).

LAMB1_MOUSE
θ value	8.99809 (rank : 1280)	NC score	0.006268 (rank : 1393)
Query Neighborhood Hits	1311	Target Neighborhood Hits	919	Shared Neighborhood Hits	154
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LMNB2_HUMAN
θ value	8.99809 (rank : 1281)	NC score	0.023706 (rank : 1265)
Query Neighborhood Hits	1311	Target Neighborhood Hits	723	Shared Neighborhood Hits	186
SwissProt Accessions	Q03252, O75292, Q14734, Q96DF6	Gene names	LMNB2, LMN2
Domain Architecture
Description	Lamin-B2.

LRC59_MOUSE
θ value	8.99809 (rank : 1282)	NC score	0.002298 (rank : 1441)
Query Neighborhood Hits	1311	Target Neighborhood Hits	415	Shared Neighborhood Hits	72
SwissProt Accessions	Q922Q8, Q3TJ35, Q3TLC7, Q3TWT9, Q3TX86	Gene names	Lrrc59
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 59.

LRRC2_MOUSE
θ value	8.99809 (rank : 1283)	NC score	-0.004742 (rank : 1489)
Query Neighborhood Hits	1311	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VDB8, Q9CX04	Gene names	Lrrc2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 2.

MYH10_MOUSE
θ value	8.99809 (rank : 1284)	NC score	0.043073 (rank : 1155)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1612	Shared Neighborhood Hits	313
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH9_MOUSE
θ value	8.99809 (rank : 1285)	NC score	0.045135 (rank : 1140)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1829	Shared Neighborhood Hits	347
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

N4BP3_MOUSE
θ value	8.99809 (rank : 1286)	NC score	0.025649 (rank : 1254)
Query Neighborhood Hits	1311	Target Neighborhood Hits	179	Shared Neighborhood Hits	75
SwissProt Accessions	Q8C7U1, Q3TDC7, Q7TNR2, Q922W0, Q99J06	Gene names	N4bp3
Domain Architecture
Description	NEDD4-binding protein 3 (N4BP3).

NARGL_HUMAN
θ value	8.99809 (rank : 1287)	NC score	0.010759 (rank : 1353)
Query Neighborhood Hits	1311	Target Neighborhood Hits	222	Shared Neighborhood Hits	70
SwissProt Accessions	Q6N069, Q5VSP9, Q6P2D5, Q8N5J3, Q8N870	Gene names	NARG1L, NAT2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

NARGL_MOUSE
θ value	8.99809 (rank : 1288)	NC score	0.006547 (rank : 1387)
Query Neighborhood Hits	1311	Target Neighborhood Hits	175	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DBB4, Q3U7V2	Gene names	Narg1l, Nat2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

NFASC_HUMAN
θ value	8.99809 (rank : 1289)	NC score	0.057873 (rank : 987)
Query Neighborhood Hits	1311	Target Neighborhood Hits	497	Shared Neighborhood Hits	101
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NFASC_MOUSE
θ value	8.99809 (rank : 1290)	NC score	0.053539 (rank : 1046)
Query Neighborhood Hits	1311	Target Neighborhood Hits	475	Shared Neighborhood Hits	100
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

NOL4_HUMAN
θ value	8.99809 (rank : 1291)	NC score	0.001219 (rank : 1454)
Query Neighborhood Hits	1311	Target Neighborhood Hits	33	Shared Neighborhood Hits	13
SwissProt Accessions	O94818, Q9BWF1	Gene names	NOL4, NOLP
Domain Architecture	No domain graphic available
Description	Nucleolar protein 4 (Nucleolar-localized protein).

OSBL6_MOUSE
θ value	8.99809 (rank : 1292)	NC score	-0.001280 (rank : 1471)
Query Neighborhood Hits	1311	Target Neighborhood Hits	105	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

PI3R4_HUMAN
θ value	8.99809 (rank : 1293)	NC score	0.359972 (rank : 841)
Query Neighborhood Hits	1311	Target Neighborhood Hits	534	Shared Neighborhood Hits	346
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	8.99809 (rank : 1294)	NC score	0.373348 (rank : 840)
Query Neighborhood Hits	1311	Target Neighborhood Hits	535	Shared Neighborhood Hits	350
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PK2L2_MOUSE
θ value	8.99809 (rank : 1295)	NC score	-0.004496 (rank : 1488)
Query Neighborhood Hits	1311	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PLCB4_HUMAN
θ value	8.99809 (rank : 1296)	NC score	0.056969 (rank : 1003)
Query Neighborhood Hits	1311	Target Neighborhood Hits	658	Shared Neighborhood Hits	221
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PTMA_HUMAN
θ value	8.99809 (rank : 1297)	NC score	0.017567 (rank : 1310)
Query Neighborhood Hits	1311	Target Neighborhood Hits	88	Shared Neighborhood Hits	25
SwissProt Accessions	P06454, Q15249, Q15592	Gene names	PTMA, TMSA
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha-1].

RERE_HUMAN
θ value	8.99809 (rank : 1298)	NC score	0.010239 (rank : 1360)
Query Neighborhood Hits	1311	Target Neighborhood Hits	779	Shared Neighborhood Hits	101
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

RERE_MOUSE
θ value	8.99809 (rank : 1299)	NC score	0.008468 (rank : 1375)
Query Neighborhood Hits	1311	Target Neighborhood Hits	785	Shared Neighborhood Hits	97
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RRS1_MOUSE
θ value	8.99809 (rank : 1300)	NC score	0.001222 (rank : 1453)
Query Neighborhood Hits	1311	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CYH6, Q3UQW6, Q9CS27, Q9D2B2, Q9D6M6, Q9JJC1	Gene names	Rrs1, Rrr
Domain Architecture
Description	Ribosome biogenesis regulatory protein homolog.

SAKS1_MOUSE
θ value	8.99809 (rank : 1301)	NC score	0.021259 (rank : 1283)
Query Neighborhood Hits	1311	Target Neighborhood Hits	208	Shared Neighborhood Hits	73
SwissProt Accessions	Q922Y1, Q3UCP8	Gene names	Saks1, D19Ertd721e
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein) (mY33K) (Protein 2B28).

SENP7_HUMAN
θ value	8.99809 (rank : 1302)	NC score	0.007362 (rank : 1382)
Query Neighborhood Hits	1311	Target Neighborhood Hits	97	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BQF6, Q96PS5, Q9C0F6, Q9HBT5	Gene names	SENP7, KIAA1707, SSP2, SUSP2
Domain Architecture
Description	Sentrin-specific protease 7 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP7) (SUMO-1-specific protease 2).

SEPT8_HUMAN
θ value	8.99809 (rank : 1303)	NC score	0.004182 (rank : 1414)
Query Neighborhood Hits	1311	Target Neighborhood Hits	290	Shared Neighborhood Hits	90
SwissProt Accessions	Q92599, Q8IX36, Q8IX37, Q9BVB3	Gene names	SEPT8, KIAA0202
Domain Architecture
Description	Septin-8.

SEPT8_MOUSE
θ value	8.99809 (rank : 1304)	NC score	0.003392 (rank : 1423)
Query Neighborhood Hits	1311	Target Neighborhood Hits	251	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CHH9, Q80YC7, Q9ESF7	Gene names	Sept8, Kiaa0202
Domain Architecture
Description	Septin-8.

ST18_MOUSE
θ value	8.99809 (rank : 1305)	NC score	0.015639 (rank : 1321)
Query Neighborhood Hits	1311	Target Neighborhood Hits	248	Shared Neighborhood Hits	71
SwissProt Accessions	Q80TY4, Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q811B4, Q8K098	Gene names	St18, Kiaa0535
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18.

SWP70_HUMAN
θ value	8.99809 (rank : 1306)	NC score	0.059664 (rank : 971)
Query Neighborhood Hits	1311	Target Neighborhood Hits	973	Shared Neighborhood Hits	241
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TNNT2_MOUSE
θ value	8.99809 (rank : 1307)	NC score	0.041216 (rank : 1162)
Query Neighborhood Hits	1311	Target Neighborhood Hits	395	Shared Neighborhood Hits	145
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TSH3_HUMAN
θ value	8.99809 (rank : 1308)	NC score	-0.010803 (rank : 1494)
Query Neighborhood Hits	1311	Target Neighborhood Hits	564	Shared Neighborhood Hits	20
SwissProt Accessions	Q63HK5, Q9H0G6, Q9P254	Gene names	TSHZ3, KIAA1474, TSH3, ZNF537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

UBF1_MOUSE
θ value	8.99809 (rank : 1309)	NC score	0.015665 (rank : 1320)
Query Neighborhood Hits	1311	Target Neighborhood Hits	419	Shared Neighborhood Hits	118
SwissProt Accessions	P25976	Gene names	Ubtf, Tcfubf, Ubf-1, Ubf1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1).

VAPB_HUMAN
θ value	8.99809 (rank : 1310)	NC score	0.002177 (rank : 1445)
Query Neighborhood Hits	1311	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	O95292, O95293, Q9P0H0	Gene names	VAPB
Domain Architecture
Description	Vesicle-associated membrane protein-associated protein B/C (VAMP- associated protein B/C) (VAMP-B/VAMP-C) (VAP-B/VAP-C).

WDR67_HUMAN
θ value	8.99809 (rank : 1311)	NC score	0.047444 (rank : 1123)
Query Neighborhood Hits	1311	Target Neighborhood Hits	782	Shared Neighborhood Hits	214
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

ACINU_HUMAN
θ value	θ > 10 (rank : 1312)	NC score	0.055732 (rank : 1021)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	254
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ANPRB_HUMAN
θ value	θ > 10 (rank : 1313)	NC score	0.570672 (rank : 817)
Query Neighborhood Hits	1311	Target Neighborhood Hits	646	Shared Neighborhood Hits	585
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	θ > 10 (rank : 1314)	NC score	0.538880 (rank : 829)
Query Neighborhood Hits	1311	Target Neighborhood Hits	607	Shared Neighborhood Hits	559
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

APS_HUMAN
θ value	θ > 10 (rank : 1315)	NC score	0.055087 (rank : 1030)
Query Neighborhood Hits	1311	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

AZI1_MOUSE
θ value	θ > 10 (rank : 1316)	NC score	0.050136 (rank : 1103)
Query Neighborhood Hits	1311	Target Neighborhood Hits	990	Shared Neighborhood Hits	240
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BOC_HUMAN
θ value	θ > 10 (rank : 1317)	NC score	0.050812 (rank : 1089)
Query Neighborhood Hits	1311	Target Neighborhood Hits	543	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

BUB1B_HUMAN
θ value	θ > 10 (rank : 1318)	NC score	0.099100 (rank : 867)
Query Neighborhood Hits	1311	Target Neighborhood Hits	208	Shared Neighborhood Hits	135
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

BUB1B_MOUSE
θ value	θ > 10 (rank : 1319)	NC score	0.082653 (rank : 880)
Query Neighborhood Hits	1311	Target Neighborhood Hits	202	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

CA065_HUMAN
θ value	θ > 10 (rank : 1320)	NC score	0.068382 (rank : 912)
Query Neighborhood Hits	1311	Target Neighborhood Hits	469	Shared Neighborhood Hits	173
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

CCD11_MOUSE
θ value	θ > 10 (rank : 1321)	NC score	0.062031 (rank : 947)
Query Neighborhood Hits	1311	Target Neighborhood Hits	498	Shared Neighborhood Hits	148
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD19_HUMAN
θ value	θ > 10 (rank : 1322)	NC score	0.063007 (rank : 941)
Query Neighborhood Hits	1311	Target Neighborhood Hits	639	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CCD21_HUMAN
θ value	θ > 10 (rank : 1323)	NC score	0.051253 (rank : 1080)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1228	Shared Neighborhood Hits	308
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	θ > 10 (rank : 1324)	NC score	0.061877 (rank : 950)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1135	Shared Neighborhood Hits	302
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD41_HUMAN
θ value	θ > 10 (rank : 1325)	NC score	0.054733 (rank : 1034)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1139	Shared Neighborhood Hits	272
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CCD45_HUMAN
θ value	θ > 10 (rank : 1326)	NC score	0.057820 (rank : 989)
Query Neighborhood Hits	1311	Target Neighborhood Hits	525	Shared Neighborhood Hits	198
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCD45_MOUSE
θ value	θ > 10 (rank : 1327)	NC score	0.061987 (rank : 948)
Query Neighborhood Hits	1311	Target Neighborhood Hits	663	Shared Neighborhood Hits	206
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCHCR_MOUSE
θ value	θ > 10 (rank : 1328)	NC score	0.053123 (rank : 1051)
Query Neighborhood Hits	1311	Target Neighborhood Hits	932	Shared Neighborhood Hits	251
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CDON_HUMAN
θ value	θ > 10 (rank : 1329)	NC score	0.050257 (rank : 1100)
Query Neighborhood Hits	1311	Target Neighborhood Hits	412	Shared Neighborhood Hits	65
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CEP63_HUMAN
θ value	θ > 10 (rank : 1330)	NC score	0.050024 (rank : 1107)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1005	Shared Neighborhood Hits	251
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CF060_HUMAN
θ value	θ > 10 (rank : 1331)	NC score	0.056024 (rank : 1017)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1270	Shared Neighborhood Hits	301
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CF182_MOUSE
θ value	θ > 10 (rank : 1332)	NC score	0.053170 (rank : 1050)
Query Neighborhood Hits	1311	Target Neighborhood Hits	551	Shared Neighborhood Hits	174
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

CHIN_HUMAN
θ value	θ > 10 (rank : 1333)	NC score	0.078810 (rank : 890)
Query Neighborhood Hits	1311	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1334)	NC score	0.079642 (rank : 888)
Query Neighborhood Hits	1311	Target Neighborhood Hits	229	Shared Neighborhood Hits	66
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1335)	NC score	0.080136 (rank : 886)
Query Neighborhood Hits	1311	Target Neighborhood Hits	220	Shared Neighborhood Hits	63
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 1336)	NC score	0.067442 (rank : 916)
Query Neighborhood Hits	1311	Target Neighborhood Hits	130	Shared Neighborhood Hits	38
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CI039_HUMAN
θ value	θ > 10 (rank : 1337)	NC score	0.059848 (rank : 967)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1171	Shared Neighborhood Hits	281
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CI093_HUMAN
θ value	θ > 10 (rank : 1338)	NC score	0.054610 (rank : 1035)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1088	Shared Neighborhood Hits	273
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CIP4_HUMAN
θ value	θ > 10 (rank : 1339)	NC score	0.059725 (rank : 968)
Query Neighborhood Hits	1311	Target Neighborhood Hits	374	Shared Neighborhood Hits	120
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CNTN2_HUMAN
θ value	θ > 10 (rank : 1340)	NC score	0.050598 (rank : 1093)
Query Neighborhood Hits	1311	Target Neighborhood Hits	440	Shared Neighborhood Hits	85
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
θ value	θ > 10 (rank : 1341)	NC score	0.050433 (rank : 1096)
Query Neighborhood Hits	1311	Target Neighborhood Hits	450	Shared Neighborhood Hits	84
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN5_HUMAN
θ value	θ > 10 (rank : 1342)	NC score	0.053184 (rank : 1049)
Query Neighborhood Hits	1311	Target Neighborhood Hits	446	Shared Neighborhood Hits	86
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CNTRB_MOUSE
θ value	θ > 10 (rank : 1343)	NC score	0.061287 (rank : 956)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1029	Shared Neighborhood Hits	257
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CP250_HUMAN
θ value	θ > 10 (rank : 1344)	NC score	0.056930 (rank : 1005)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1805	Shared Neighborhood Hits	353
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CRKL_HUMAN
θ value	θ > 10 (rank : 1345)	NC score	0.067347 (rank : 917)
Query Neighborhood Hits	1311	Target Neighborhood Hits	313	Shared Neighborhood Hits	59
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 1346)	NC score	0.068188 (rank : 914)
Query Neighborhood Hits	1311	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 1347)	NC score	0.058742 (rank : 979)
Query Neighborhood Hits	1311	Target Neighborhood Hits	308	Shared Neighborhood Hits	58
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 1348)	NC score	0.057329 (rank : 996)
Query Neighborhood Hits	1311	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	θ > 10 (rank : 1349)	NC score	0.071998 (rank : 903)
Query Neighborhood Hits	1311	Target Neighborhood Hits	227	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 1350)	NC score	0.070023 (rank : 905)
Query Neighborhood Hits	1311	Target Neighborhood Hits	225	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCC_HUMAN
θ value	θ > 10 (rank : 1351)	NC score	0.062989 (rank : 942)
Query Neighborhood Hits	1311	Target Neighborhood Hits	583	Shared Neighborhood Hits	96
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
θ value	θ > 10 (rank : 1352)	NC score	0.063807 (rank : 934)
Query Neighborhood Hits	1311	Target Neighborhood Hits	896	Shared Neighborhood Hits	134
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DCX_HUMAN
θ value	θ > 10 (rank : 1353)	NC score	0.060120 (rank : 962)
Query Neighborhood Hits	1311	Target Neighborhood Hits	141	Shared Neighborhood Hits	33
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCX_MOUSE
θ value	θ > 10 (rank : 1354)	NC score	0.057229 (rank : 998)
Query Neighborhood Hits	1311	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DGKB_HUMAN
θ value	θ > 10 (rank : 1355)	NC score	0.054020 (rank : 1043)
Query Neighborhood Hits	1311	Target Neighborhood Hits	238	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKD_HUMAN
θ value	θ > 10 (rank : 1356)	NC score	0.080108 (rank : 887)
Query Neighborhood Hits	1311	Target Neighborhood Hits	231	Shared Neighborhood Hits	82
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKG_MOUSE
θ value	θ > 10 (rank : 1357)	NC score	0.051761 (rank : 1069)
Query Neighborhood Hits	1311	Target Neighborhood Hits	188	Shared Neighborhood Hits	37
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1358)	NC score	0.073086 (rank : 899)
Query Neighborhood Hits	1311	Target Neighborhood Hits	255	Shared Neighborhood Hits	71
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1359)	NC score	0.068812 (rank : 911)
Query Neighborhood Hits	1311	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

DSCAM_HUMAN
θ value	θ > 10 (rank : 1360)	NC score	0.060195 (rank : 961)
Query Neighborhood Hits	1311	Target Neighborhood Hits	524	Shared Neighborhood Hits	86
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DSCL1_HUMAN
θ value	θ > 10 (rank : 1361)	NC score	0.062135 (rank : 946)
Query Neighborhood Hits	1311	Target Neighborhood Hits	589	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

FGRL1_HUMAN
θ value	θ > 10 (rank : 1362)	NC score	0.066728 (rank : 919)
Query Neighborhood Hits	1311	Target Neighborhood Hits	335	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

FGRL1_MOUSE
θ value	θ > 10 (rank : 1363)	NC score	0.068357 (rank : 913)
Query Neighborhood Hits	1311	Target Neighborhood Hits	325	Shared Neighborhood Hits	49
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

GAS8_HUMAN
θ value	θ > 10 (rank : 1364)	NC score	0.057289 (rank : 997)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	230
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GAS8_MOUSE
θ value	θ > 10 (rank : 1365)	NC score	0.058828 (rank : 977)
Query Neighborhood Hits	1311	Target Neighborhood Hits	622	Shared Neighborhood Hits	194
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GLE1_MOUSE
θ value	θ > 10 (rank : 1366)	NC score	0.050336 (rank : 1098)
Query Neighborhood Hits	1311	Target Neighborhood Hits	504	Shared Neighborhood Hits	182
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

GOGA1_MOUSE
θ value	θ > 10 (rank : 1367)	NC score	0.051351 (rank : 1078)
Query Neighborhood Hits	1311	Target Neighborhood Hits	994	Shared Neighborhood Hits	246
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

GOGA5_MOUSE
θ value	θ > 10 (rank : 1368)	NC score	0.051040 (rank : 1083)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1434	Shared Neighborhood Hits	316
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

GOGA6_HUMAN
θ value	θ > 10 (rank : 1369)	NC score	0.051427 (rank : 1075)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1007	Shared Neighborhood Hits	251
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

GRAP1_HUMAN
θ value	θ > 10 (rank : 1370)	NC score	0.052050 (rank : 1063)
Query Neighborhood Hits	1311	Target Neighborhood Hits	944	Shared Neighborhood Hits	236
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

GRAP1_MOUSE
θ value	θ > 10 (rank : 1371)	NC score	0.057567 (rank : 991)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1234	Shared Neighborhood Hits	288
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

GRAP2_HUMAN
θ value	θ > 10 (rank : 1372)	NC score	0.100128 (rank : 865)
Query Neighborhood Hits	1311	Target Neighborhood Hits	304	Shared Neighborhood Hits	59
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1373)	NC score	0.098511 (rank : 868)
Query Neighborhood Hits	1311	Target Neighborhood Hits	297	Shared Neighborhood Hits	58
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 1374)	NC score	0.103832 (rank : 858)
Query Neighborhood Hits	1311	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 1375)	NC score	0.103295 (rank : 859)
Query Neighborhood Hits	1311	Target Neighborhood Hits	309	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB14_HUMAN
θ value	θ > 10 (rank : 1376)	NC score	0.056463 (rank : 1009)
Query Neighborhood Hits	1311	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 1377)	NC score	0.061847 (rank : 952)
Query Neighborhood Hits	1311	Target Neighborhood Hits	149	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 1378)	NC score	0.100547 (rank : 862)
Query Neighborhood Hits	1311	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1379)	NC score	0.100495 (rank : 863)
Query Neighborhood Hits	1311	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB7_MOUSE
θ value	θ > 10 (rank : 1380)	NC score	0.052281 (rank : 1058)
Query Neighborhood Hits	1311	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRP3_HUMAN
θ value	θ > 10 (rank : 1381)	NC score	0.100002 (rank : 866)
Query Neighborhood Hits	1311	Target Neighborhood Hits	131	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HIP1_HUMAN
θ value	θ > 10 (rank : 1382)	NC score	0.051764 (rank : 1068)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1016	Shared Neighborhood Hits	268
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

HSH2D_HUMAN
θ value	θ > 10 (rank : 1383)	NC score	0.064248 (rank : 931)
Query Neighborhood Hits	1311	Target Neighborhood Hits	159	Shared Neighborhood Hits	43
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

INVO_HUMAN
θ value	θ > 10 (rank : 1384)	NC score	0.061861 (rank : 951)
Query Neighborhood Hits	1311	Target Neighborhood Hits	636	Shared Neighborhood Hits	187
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

INVO_MOUSE
θ value	θ > 10 (rank : 1385)	NC score	0.066893 (rank : 918)
Query Neighborhood Hits	1311	Target Neighborhood Hits	474	Shared Neighborhood Hits	146
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

ITSN2_HUMAN
θ value	θ > 10 (rank : 1386)	NC score	0.065757 (rank : 923)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1173	Shared Neighborhood Hits	249
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 1387)	NC score	0.067585 (rank : 915)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1371	Shared Neighborhood Hits	310
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

K0555_HUMAN
θ value	θ > 10 (rank : 1388)	NC score	0.060086 (rank : 964)
Query Neighborhood Hits	1311	Target Neighborhood Hits	880	Shared Neighborhood Hits	236
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

KTN1_MOUSE
θ value	θ > 10 (rank : 1389)	NC score	0.050025 (rank : 1106)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1324	Shared Neighborhood Hits	297
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

L1CAM_HUMAN
θ value	θ > 10 (rank : 1390)	NC score	0.058758 (rank : 978)
Query Neighborhood Hits	1311	Target Neighborhood Hits	457	Shared Neighborhood Hits	91
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

L1CAM_MOUSE
θ value	θ > 10 (rank : 1391)	NC score	0.055951 (rank : 1018)
Query Neighborhood Hits	1311	Target Neighborhood Hits	457	Shared Neighborhood Hits	92
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

LNK_HUMAN
θ value	θ > 10 (rank : 1392)	NC score	0.051999 (rank : 1065)
Query Neighborhood Hits	1311	Target Neighborhood Hits	151	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRC45_MOUSE
θ value	θ > 10 (rank : 1393)	NC score	0.053984 (rank : 1044)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	244
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LUZP1_MOUSE
θ value	θ > 10 (rank : 1394)	NC score	0.051167 (rank : 1081)
Query Neighborhood Hits	1311	Target Neighborhood Hits	940	Shared Neighborhood Hits	253
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

MD1L1_HUMAN
θ value	θ > 10 (rank : 1395)	NC score	0.055150 (rank : 1028)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	241
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MYOM1_HUMAN
θ value	θ > 10 (rank : 1396)	NC score	0.064895 (rank : 927)
Query Neighborhood Hits	1311	Target Neighborhood Hits	405	Shared Neighborhood Hits	100
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MYOM1_MOUSE
θ value	θ > 10 (rank : 1397)	NC score	0.064998 (rank : 926)
Query Neighborhood Hits	1311	Target Neighborhood Hits	415	Shared Neighborhood Hits	94
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MYOM2_HUMAN
θ value	θ > 10 (rank : 1398)	NC score	0.060366 (rank : 959)
Query Neighborhood Hits	1311	Target Neighborhood Hits	341	Shared Neighborhood Hits	79
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

MYOTI_HUMAN
θ value	θ > 10 (rank : 1399)	NC score	0.055816 (rank : 1020)
Query Neighborhood Hits	1311	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

MYOTI_MOUSE
θ value	θ > 10 (rank : 1400)	NC score	0.053317 (rank : 1048)
Query Neighborhood Hits	1311	Target Neighborhood Hits	297	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

MYPC3_HUMAN
θ value	θ > 10 (rank : 1401)	NC score	0.056962 (rank : 1004)
Query Neighborhood Hits	1311	Target Neighborhood Hits	318	Shared Neighborhood Hits	74
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPC3_MOUSE
θ value	θ > 10 (rank : 1402)	NC score	0.060034 (rank : 965)
Query Neighborhood Hits	1311	Target Neighborhood Hits	310	Shared Neighborhood Hits	71
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

MYPN_HUMAN
θ value	θ > 10 (rank : 1403)	NC score	0.056223 (rank : 1013)
Query Neighborhood Hits	1311	Target Neighborhood Hits	418	Shared Neighborhood Hits	71
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

MYPN_MOUSE
θ value	θ > 10 (rank : 1404)	NC score	0.056071 (rank : 1015)
Query Neighborhood Hits	1311	Target Neighborhood Hits	421	Shared Neighborhood Hits	65
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

NCA11_HUMAN
θ value	θ > 10 (rank : 1405)	NC score	0.052758 (rank : 1054)
Query Neighborhood Hits	1311	Target Neighborhood Hits	443	Shared Neighborhood Hits	73
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA12_HUMAN
θ value	θ > 10 (rank : 1406)	NC score	0.052137 (rank : 1060)
Query Neighborhood Hits	1311	Target Neighborhood Hits	437	Shared Neighborhood Hits	73
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

NCAM2_HUMAN
θ value	θ > 10 (rank : 1407)	NC score	0.058188 (rank : 983)
Query Neighborhood Hits	1311	Target Neighborhood Hits	441	Shared Neighborhood Hits	80
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NCAM2_MOUSE
θ value	θ > 10 (rank : 1408)	NC score	0.059723 (rank : 969)
Query Neighborhood Hits	1311	Target Neighborhood Hits	472	Shared Neighborhood Hits	82
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCK1_HUMAN
θ value	θ > 10 (rank : 1409)	NC score	0.095736 (rank : 870)
Query Neighborhood Hits	1311	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 1410)	NC score	0.095893 (rank : 869)
Query Neighborhood Hits	1311	Target Neighborhood Hits	310	Shared Neighborhood Hits	61
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEMO_HUMAN
θ value	θ > 10 (rank : 1411)	NC score	0.058345 (rank : 980)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	231
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

NEO1_HUMAN
θ value	θ > 10 (rank : 1412)	NC score	0.069042 (rank : 909)
Query Neighborhood Hits	1311	Target Neighborhood Hits	530	Shared Neighborhood Hits	102
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

NEO1_MOUSE
θ value	θ > 10 (rank : 1413)	NC score	0.069127 (rank : 908)
Query Neighborhood Hits	1311	Target Neighborhood Hits	523	Shared Neighborhood Hits	105
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NPHP1_HUMAN
θ value	θ > 10 (rank : 1414)	NC score	0.055063 (rank : 1031)
Query Neighborhood Hits	1311	Target Neighborhood Hits	288	Shared Neighborhood Hits	81
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 1415)	NC score	0.054289 (rank : 1037)
Query Neighborhood Hits	1311	Target Neighborhood Hits	267	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NRCAM_HUMAN
θ value	θ > 10 (rank : 1416)	NC score	0.057482 (rank : 993)
Query Neighborhood Hits	1311	Target Neighborhood Hits	439	Shared Neighborhood Hits	93
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

NRCAM_MOUSE
θ value	θ > 10 (rank : 1417)	NC score	0.055520 (rank : 1024)
Query Neighborhood Hits	1311	Target Neighborhood Hits	432	Shared Neighborhood Hits	93
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

OBSL1_HUMAN
θ value	θ > 10 (rank : 1418)	NC score	0.054218 (rank : 1039)
Query Neighborhood Hits	1311	Target Neighborhood Hits	354	Shared Neighborhood Hits	54
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

P55G_HUMAN
θ value	θ > 10 (rank : 1419)	NC score	0.072108 (rank : 901)
Query Neighborhood Hits	1311	Target Neighborhood Hits	451	Shared Neighborhood Hits	155
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 1420)	NC score	0.071823 (rank : 904)
Query Neighborhood Hits	1311	Target Neighborhood Hits	401	Shared Neighborhood Hits	133
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 1421)	NC score	0.057950 (rank : 985)
Query Neighborhood Hits	1311	Target Neighborhood Hits	479	Shared Neighborhood Hits	143
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 1422)	NC score	0.055496 (rank : 1025)
Query Neighborhood Hits	1311	Target Neighborhood Hits	435	Shared Neighborhood Hits	128
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 1423)	NC score	0.075667 (rank : 895)
Query Neighborhood Hits	1311	Target Neighborhood Hits	543	Shared Neighborhood Hits	188
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 1424)	NC score	0.076975 (rank : 893)
Query Neighborhood Hits	1311	Target Neighborhood Hits	519	Shared Neighborhood Hits	179
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACE1_HUMAN
θ value	θ > 10 (rank : 1425)	NC score	0.081125 (rank : 883)
Query Neighborhood Hits	1311	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PACE1_MOUSE
θ value	θ > 10 (rank : 1426)	NC score	0.084292 (rank : 879)
Query Neighborhood Hits	1311	Target Neighborhood Hits	92	Shared Neighborhood Hits	61
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PCNT_HUMAN
θ value	θ > 10 (rank : 1427)	NC score	0.055818 (rank : 1019)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1551	Shared Neighborhood Hits	327
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

PCNT_MOUSE
θ value	θ > 10 (rank : 1428)	NC score	0.055269 (rank : 1026)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1207	Shared Neighborhood Hits	271
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

PDZD8_HUMAN
θ value	θ > 10 (rank : 1429)	NC score	0.078900 (rank : 889)
Query Neighborhood Hits	1311	Target Neighborhood Hits	185	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PGFRL_HUMAN
θ value	θ > 10 (rank : 1430)	NC score	0.054795 (rank : 1032)
Query Neighborhood Hits	1311	Target Neighborhood Hits	115	Shared Neighborhood Hits	28
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PGFRL_MOUSE
θ value	θ > 10 (rank : 1431)	NC score	0.053971 (rank : 1045)
Query Neighborhood Hits	1311	Target Neighborhood Hits	106	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PHLB2_HUMAN
θ value	θ > 10 (rank : 1432)	NC score	0.050688 (rank : 1090)
Query Neighborhood Hits	1311	Target Neighborhood Hits	964	Shared Neighborhood Hits	265
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHLB2_MOUSE
θ value	θ > 10 (rank : 1433)	NC score	0.052698 (rank : 1055)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1016	Shared Neighborhood Hits	283
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PIBF1_HUMAN
θ value	θ > 10 (rank : 1434)	NC score	0.059360 (rank : 974)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1041	Shared Neighborhood Hits	273
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

PININ_MOUSE
θ value	θ > 10 (rank : 1435)	NC score	0.061965 (rank : 949)
Query Neighborhood Hits	1311	Target Neighborhood Hits	777	Shared Neighborhood Hits	241
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PLCG1_HUMAN
θ value	θ > 10 (rank : 1436)	NC score	0.062378 (rank : 945)
Query Neighborhood Hits	1311	Target Neighborhood Hits	293	Shared Neighborhood Hits	67
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 1437)	NC score	0.063146 (rank : 940)
Query Neighborhood Hits	1311	Target Neighborhood Hits	314	Shared Neighborhood Hits	72
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 1438)	NC score	0.060941 (rank : 958)
Query Neighborhood Hits	1311	Target Neighborhood Hits	280	Shared Neighborhood Hits	59
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PRPK_HUMAN
θ value	θ > 10 (rank : 1439)	NC score	0.154840 (rank : 852)
Query Neighborhood Hits	1311	Target Neighborhood Hits	131	Shared Neighborhood Hits	129
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 1440)	NC score	0.157741 (rank : 850)
Query Neighborhood Hits	1311	Target Neighborhood Hits	139	Shared Neighborhood Hits	131
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PTPRD_HUMAN
θ value	θ > 10 (rank : 1441)	NC score	0.051312 (rank : 1079)
Query Neighborhood Hits	1311	Target Neighborhood Hits	485	Shared Neighborhood Hits	90
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	θ > 10 (rank : 1442)	NC score	0.050833 (rank : 1088)
Query Neighborhood Hits	1311	Target Neighborhood Hits	491	Shared Neighborhood Hits	88
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRF_HUMAN
θ value	θ > 10 (rank : 1443)	NC score	0.050057 (rank : 1105)
Query Neighborhood Hits	1311	Target Neighborhood Hits	489	Shared Neighborhood Hits	92
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

PTPRS_HUMAN
θ value	θ > 10 (rank : 1444)	NC score	0.050461 (rank : 1095)
Query Neighborhood Hits	1311	Target Neighborhood Hits	472	Shared Neighborhood Hits	93
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

PUNC_HUMAN
θ value	θ > 10 (rank : 1445)	NC score	0.051056 (rank : 1082)
Query Neighborhood Hits	1311	Target Neighborhood Hits	449	Shared Neighborhood Hits	69
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

PXK_HUMAN
θ value	θ > 10 (rank : 1446)	NC score	0.142842 (rank : 853)
Query Neighborhood Hits	1311	Target Neighborhood Hits	216	Shared Neighborhood Hits	134
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RAD50_MOUSE
θ value	θ > 10 (rank : 1447)	NC score	0.052433 (rank : 1057)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1366	Shared Neighborhood Hits	295
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RASA1_HUMAN
θ value	θ > 10 (rank : 1448)	NC score	0.081595 (rank : 882)
Query Neighborhood Hits	1311	Target Neighborhood Hits	258	Shared Neighborhood Hits	61
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_HUMAN
θ value	θ > 10 (rank : 1449)	NC score	0.064340 (rank : 930)
Query Neighborhood Hits	1311	Target Neighborhood Hits	62	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 1450)	NC score	0.078054 (rank : 892)
Query Neighborhood Hits	1311	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RBCC1_HUMAN
θ value	θ > 10 (rank : 1451)	NC score	0.051403 (rank : 1077)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1023	Shared Neighborhood Hits	243
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

RGNEF_MOUSE
θ value	θ > 10 (rank : 1452)	NC score	0.059947 (rank : 966)
Query Neighborhood Hits	1311	Target Neighborhood Hits	641	Shared Neighborhood Hits	227
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RIOK2_MOUSE
θ value	θ > 10 (rank : 1453)	NC score	0.050402 (rank : 1097)
Query Neighborhood Hits	1311	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

RN5A_HUMAN
θ value	θ > 10 (rank : 1454)	NC score	0.155360 (rank : 851)
Query Neighborhood Hits	1311	Target Neighborhood Hits	608	Shared Neighborhood Hits	333
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ROBO1_HUMAN
θ value	θ > 10 (rank : 1455)	NC score	0.057865 (rank : 988)
Query Neighborhood Hits	1311	Target Neighborhood Hits	529	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO1_MOUSE
θ value	θ > 10 (rank : 1456)	NC score	0.058203 (rank : 982)
Query Neighborhood Hits	1311	Target Neighborhood Hits	559	Shared Neighborhood Hits	94
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO2_HUMAN
θ value	θ > 10 (rank : 1457)	NC score	0.056820 (rank : 1006)
Query Neighborhood Hits	1311	Target Neighborhood Hits	479	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_MOUSE
θ value	θ > 10 (rank : 1458)	NC score	0.057079 (rank : 1000)
Query Neighborhood Hits	1311	Target Neighborhood Hits	504	Shared Neighborhood Hits	85
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO3_HUMAN
θ value	θ > 10 (rank : 1459)	NC score	0.055600 (rank : 1023)
Query Neighborhood Hits	1311	Target Neighborhood Hits	570	Shared Neighborhood Hits	92
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

ROBO3_MOUSE
θ value	θ > 10 (rank : 1460)	NC score	0.052928 (rank : 1052)
Query Neighborhood Hits	1311	Target Neighborhood Hits	524	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

SDCG8_HUMAN
θ value	θ > 10 (rank : 1461)	NC score	0.056194 (rank : 1014)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1002	Shared Neighborhood Hits	281
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

SDCG8_MOUSE
θ value	θ > 10 (rank : 1462)	NC score	0.054370 (rank : 1036)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	260
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SDK1_HUMAN
θ value	θ > 10 (rank : 1463)	NC score	0.061689 (rank : 953)
Query Neighborhood Hits	1311	Target Neighborhood Hits	511	Shared Neighborhood Hits	93
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK1_MOUSE
θ value	θ > 10 (rank : 1464)	NC score	0.060089 (rank : 963)
Query Neighborhood Hits	1311	Target Neighborhood Hits	495	Shared Neighborhood Hits	97
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SDK2_HUMAN
θ value	θ > 10 (rank : 1465)	NC score	0.059653 (rank : 972)
Query Neighborhood Hits	1311	Target Neighborhood Hits	495	Shared Neighborhood Hits	97
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
θ value	θ > 10 (rank : 1466)	NC score	0.058285 (rank : 981)
Query Neighborhood Hits	1311	Target Neighborhood Hits	480	Shared Neighborhood Hits	97
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SH21A_HUMAN
θ value	θ > 10 (rank : 1467)	NC score	0.078426 (rank : 891)
Query Neighborhood Hits	1311	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 1468)	NC score	0.084681 (rank : 877)
Query Neighborhood Hits	1311	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 1469)	NC score	0.084680 (rank : 878)
Query Neighborhood Hits	1311	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 1470)	NC score	0.094533 (rank : 871)
Query Neighborhood Hits	1311	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH24A_HUMAN
θ value	θ > 10 (rank : 1471)	NC score	0.081076 (rank : 884)
Query Neighborhood Hits	1311	Target Neighborhood Hits	455	Shared Neighborhood Hits	192
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 1472)	NC score	0.050941 (rank : 1087)
Query Neighborhood Hits	1311	Target Neighborhood Hits	326	Shared Neighborhood Hits	135
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SHB_MOUSE
θ value	θ > 10 (rank : 1473)	NC score	0.051550 (rank : 1071)
Query Neighborhood Hits	1311	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 1474)	NC score	0.050624 (rank : 1092)
Query Neighborhood Hits	1311	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 1475)	NC score	0.050269 (rank : 1099)
Query Neighborhood Hits	1311	Target Neighborhood Hits	180	Shared Neighborhood Hits	50
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 1476)	NC score	0.050208 (rank : 1101)
Query Neighborhood Hits	1311	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHE_HUMAN
θ value	θ > 10 (rank : 1477)	NC score	0.063592 (rank : 935)
Query Neighborhood Hits	1311	Target Neighborhood Hits	164	Shared Neighborhood Hits	49
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 1478)	NC score	0.063306 (rank : 937)
Query Neighborhood Hits	1311	Target Neighborhood Hits	169	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 1479)	NC score	0.135188 (rank : 856)
Query Neighborhood Hits	1311	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 1480)	NC score	0.133176 (rank : 857)
Query Neighborhood Hits	1311	Target Neighborhood Hits	117	Shared Neighborhood Hits	41
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 1481)	NC score	0.137338 (rank : 855)
Query Neighborhood Hits	1311	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 1482)	NC score	0.141265 (rank : 854)
Query Neighborhood Hits	1311	Target Neighborhood Hits	136	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SPN90_HUMAN
θ value	θ > 10 (rank : 1483)	NC score	0.050127 (rank : 1104)
Query Neighborhood Hits	1311	Target Neighborhood Hits	157	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

STAC3_HUMAN
θ value	θ > 10 (rank : 1484)	NC score	0.100438 (rank : 864)
Query Neighborhood Hits	1311	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 1485)	NC score	0.101044 (rank : 860)
Query Neighborhood Hits	1311	Target Neighborhood Hits	232	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 1486)	NC score	0.093801 (rank : 872)
Query Neighborhood Hits	1311	Target Neighborhood Hits	276	Shared Neighborhood Hits	80
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 1487)	NC score	0.100627 (rank : 861)
Query Neighborhood Hits	1311	Target Neighborhood Hits	268	Shared Neighborhood Hits	79
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SWP70_MOUSE
θ value	θ > 10 (rank : 1488)	NC score	0.063320 (rank : 936)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1097	Shared Neighborhood Hits	272
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TSC1_HUMAN
θ value	θ > 10 (rank : 1489)	NC score	0.051418 (rank : 1076)
Query Neighborhood Hits	1311	Target Neighborhood Hits	765	Shared Neighborhood Hits	188
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

UN13A_HUMAN
θ value	θ > 10 (rank : 1490)	NC score	0.074696 (rank : 897)
Query Neighborhood Hits	1311	Target Neighborhood Hits	285	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 1491)	NC score	0.072192 (rank : 900)
Query Neighborhood Hits	1311	Target Neighborhood Hits	217	Shared Neighborhood Hits	53
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 1492)	NC score	0.069316 (rank : 906)
Query Neighborhood Hits	1311	Target Neighborhood Hits	210	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 1493)	NC score	0.085448 (rank : 876)
Query Neighborhood Hits	1311	Target Neighborhood Hits	453	Shared Neighborhood Hits	102
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1494)	NC score	0.081901 (rank : 881)
Query Neighborhood Hits	1311	Target Neighborhood Hits	456	Shared Neighborhood Hits	97
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1495)	NC score	0.088841 (rank : 873)
Query Neighborhood Hits	1311	Target Neighborhood Hits	398	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 1496)	NC score	0.088818 (rank : 874)
Query Neighborhood Hits	1311	Target Neighborhood Hits	404	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1497)	NC score	0.086777 (rank : 875)
Query Neighborhood Hits	1311	Target Neighborhood Hits	452	Shared Neighborhood Hits	109
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1498)	NC score	0.080642 (rank : 885)
Query Neighborhood Hits	1311	Target Neighborhood Hits	430	Shared Neighborhood Hits	99
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VRK3_HUMAN
θ value	θ > 10 (rank : 1499)	NC score	0.273375 (rank : 847)
Query Neighborhood Hits	1311	Target Neighborhood Hits	349	Shared Neighborhood Hits	311
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VRK3_MOUSE
θ value	θ > 10 (rank : 1500)	NC score	0.261253 (rank : 848)
Query Neighborhood Hits	1311	Target Neighborhood Hits	342	Shared Neighborhood Hits	322
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

ZC313_HUMAN
θ value	θ > 10 (rank : 1501)	NC score	0.066018 (rank : 921)
Query Neighborhood Hits	1311	Target Neighborhood Hits	772	Shared Neighborhood Hits	248
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

Hits sorted by NC score

NEK1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1311	Shared Neighborhood Hits	1311
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

NEK1_HUMAN
NC score	0.993698 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1129	Shared Neighborhood Hits	980
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

NEK3_HUMAN
NC score	0.985557 (rank : 3)	θ value	1.88829e-90 (rank : 3)
Query Neighborhood Hits	1311	Target Neighborhood Hits	865	Shared Neighborhood Hits	849
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK3_MOUSE
NC score	0.985309 (rank : 4)	θ value	8.20983e-86 (rank : 4)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	841
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

NEK4_MOUSE
NC score	0.983529 (rank : 5)	θ value	5.69867e-79 (rank : 5)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	848
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

NEK4_HUMAN
NC score	0.982388 (rank : 6)	θ value	9.7205e-79 (rank : 6)
Query Neighborhood Hits	1311	Target Neighborhood Hits	883	Shared Neighborhood Hits	842
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK2_HUMAN
NC score	0.978381 (rank : 7)	θ value	2.041e-52 (rank : 13)
Query Neighborhood Hits	1311	Target Neighborhood Hits	908	Shared Neighborhood Hits	845
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
NC score	0.977066 (rank : 8)	θ value	5.93839e-52 (rank : 14)
Query Neighborhood Hits	1311	Target Neighborhood Hits	876	Shared Neighborhood Hits	833
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NEK11_HUMAN
NC score	0.976967 (rank : 9)	θ value	5.54529e-58 (rank : 11)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1043	Shared Neighborhood Hits	911
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK6_HUMAN
NC score	0.976949 (rank : 10)	θ value	1.97686e-47 (rank : 15)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	842
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.976842 (rank : 11)	θ value	1.28137e-46 (rank : 17)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	842
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

NEK11_MOUSE
NC score	0.976482 (rank : 12)	θ value	8.00737e-57 (rank : 12)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	843
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK7_MOUSE
NC score	0.976394 (rank : 13)	θ value	1.28137e-46 (rank : 18)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	842
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

NEK7_HUMAN
NC score	0.976358 (rank : 14)	θ value	1.97686e-47 (rank : 16)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	841
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

STK36_HUMAN
NC score	0.971939 (rank : 15)	θ value	3.99248e-40 (rank : 19)
Query Neighborhood Hits	1311	Target Neighborhood Hits	896	Shared Neighborhood Hits	848
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

STK36_MOUSE
NC score	0.970843 (rank : 16)	θ value	1.57e-36 (rank : 20)
Query Neighborhood Hits	1311	Target Neighborhood Hits	877	Shared Neighborhood Hits	847
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

NEK8_HUMAN
NC score	0.966226 (rank : 17)	θ value	7.98882e-65 (rank : 7)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	841
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
NC score	0.965993 (rank : 18)	θ value	1.36269e-64 (rank : 8)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	840
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

PLK4_MOUSE
NC score	0.965964 (rank : 19)	θ value	8.61488e-35 (rank : 24)
Query Neighborhood Hits	1311	Target Neighborhood Hits	879	Shared Neighborhood Hits	841
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PLK2_HUMAN
NC score	0.965688 (rank : 20)	θ value	3.27365e-34 (rank : 27)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	838
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
NC score	0.965415 (rank : 21)	θ value	3.27365e-34 (rank : 28)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	837
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

E2AK2_MOUSE
NC score	0.965188 (rank : 22)	θ value	1.73987e-27 (rank : 138)
Query Neighborhood Hits	1311	Target Neighborhood Hits	864	Shared Neighborhood Hits	835
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

PLK1_HUMAN
NC score	0.964911 (rank : 23)	θ value	7.54701e-31 (rank : 70)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	834
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK4_HUMAN
NC score	0.964791 (rank : 24)	θ value	7.29293e-34 (rank : 31)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	843
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

AURKC_MOUSE
NC score	0.964754 (rank : 25)	θ value	2.42779e-29 (rank : 98)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	842
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

STK6_HUMAN
NC score	0.964753 (rank : 26)	θ value	3.50572e-28 (rank : 126)
Query Neighborhood Hits	1311	Target Neighborhood Hits	916	Shared Neighborhood Hits	852
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

ULK3_MOUSE
NC score	0.964350 (rank : 27)	θ value	5.06226e-27 (rank : 147)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	839
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

PLK3_HUMAN
NC score	0.964287 (rank : 28)	θ value	3.27365e-34 (rank : 29)
Query Neighborhood Hits	1311	Target Neighborhood Hits	865	Shared Neighborhood Hits	840
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

AURKC_HUMAN
NC score	0.964245 (rank : 29)	θ value	1.02001e-27 (rank : 133)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	841
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

ULK2_MOUSE
NC score	0.964114 (rank : 30)	θ value	2.68423e-28 (rank : 122)
Query Neighborhood Hits	1311	Target Neighborhood Hits	943	Shared Neighborhood Hits	848
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

PLK3_MOUSE
NC score	0.963904 (rank : 31)	θ value	1.24399e-33 (rank : 35)
Query Neighborhood Hits	1311	Target Neighborhood Hits	863	Shared Neighborhood Hits	840
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

ULK3_HUMAN
NC score	0.963890 (rank : 32)	θ value	4.15078e-21 (rank : 337)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	825
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

STK6_MOUSE
NC score	0.963887 (rank : 33)	θ value	1.24688e-25 (rank : 182)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	846
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

M3K4_HUMAN
NC score	0.963583 (rank : 34)	θ value	1.16434e-31 (rank : 55)
Query Neighborhood Hits	1311	Target Neighborhood Hits	911	Shared Neighborhood Hits	848
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

PLK1_MOUSE
NC score	0.963332 (rank : 35)	θ value	1.4233e-29 (rank : 94)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	835
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

ULK2_HUMAN
NC score	0.962932 (rank : 36)	θ value	2.68423e-28 (rank : 121)
Query Neighborhood Hits	1311	Target Neighborhood Hits	979	Shared Neighborhood Hits	845
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

M3K4_MOUSE
NC score	0.962910 (rank : 37)	θ value	1.16434e-31 (rank : 56)
Query Neighborhood Hits	1311	Target Neighborhood Hits	924	Shared Neighborhood Hits	848
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

YSK4_HUMAN
NC score	0.962893 (rank : 38)	θ value	3.87602e-27 (rank : 145)
Query Neighborhood Hits	1311	Target Neighborhood Hits	921	Shared Neighborhood Hits	855
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

PAK7_HUMAN
NC score	0.962762 (rank : 39)	θ value	2.68423e-28 (rank : 116)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	842
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

ULK1_HUMAN
NC score	0.962709 (rank : 40)	θ value	5.22648e-32 (rank : 48)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1121	Shared Neighborhood Hits	853
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

M3K1_MOUSE
NC score	0.962670 (rank : 41)	θ value	2.77775e-25 (rank : 196)
Query Neighborhood Hits	1311	Target Neighborhood Hits	952	Shared Neighborhood Hits	845
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

M3K3_HUMAN
NC score	0.962400 (rank : 42)	θ value	1.02001e-27 (rank : 134)
Query Neighborhood Hits	1311	Target Neighborhood Hits	885	Shared Neighborhood Hits	844
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

PAK7_MOUSE
NC score	0.962381 (rank : 43)	θ value	2.68423e-28 (rank : 117)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	842
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PAK6_HUMAN
NC score	0.962186 (rank : 44)	θ value	1.2049e-28 (rank : 112)
Query Neighborhood Hits	1311	Target Neighborhood Hits	915	Shared Neighborhood Hits	841
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

M3K3_MOUSE
NC score	0.962132 (rank : 45)	θ value	1.33217e-27 (rank : 137)
Query Neighborhood Hits	1311	Target Neighborhood Hits	876	Shared Neighborhood Hits	841
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

AURKB_MOUSE
NC score	0.961962 (rank : 46)	θ value	3.50572e-28 (rank : 123)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	843
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

PAK2_MOUSE
NC score	0.961816 (rank : 47)	θ value	8.3442e-30 (rank : 89)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	846
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

PAK2_HUMAN
NC score	0.961773 (rank : 48)	θ value	1.08979e-29 (rank : 91)
Query Neighborhood Hits	1311	Target Neighborhood Hits	862	Shared Neighborhood Hits	848
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

STK33_HUMAN
NC score	0.961579 (rank : 49)	θ value	2.12685e-25 (rank : 194)
Query Neighborhood Hits	1311	Target Neighborhood Hits	879	Shared Neighborhood Hits	845
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

PAK4_HUMAN
NC score	0.961474 (rank : 50)	θ value	1.4233e-29 (rank : 93)
Query Neighborhood Hits	1311	Target Neighborhood Hits	924	Shared Neighborhood Hits	847
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

AURKB_HUMAN
NC score	0.961267 (rank : 51)	θ value	7.80994e-28 (rank : 129)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	841
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

NUAK2_HUMAN
NC score	0.960967 (rank : 52)	θ value	2.86786e-30 (rank : 82)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	841
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

NEK9_HUMAN
NC score	0.960770 (rank : 53)	θ value	1.41016e-61 (rank : 9)
Query Neighborhood Hits	1311	Target Neighborhood Hits	900	Shared Neighborhood Hits	844
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

M3K6_HUMAN
NC score	0.960485 (rank : 54)	θ value	2.77775e-25 (rank : 197)
Query Neighborhood Hits	1311	Target Neighborhood Hits	889	Shared Neighborhood Hits	837
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

NEK9_MOUSE
NC score	0.960299 (rank : 55)	θ value	1.19377e-60 (rank : 10)
Query Neighborhood Hits	1311	Target Neighborhood Hits	890	Shared Neighborhood Hits	845
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

M3K2_HUMAN
NC score	0.960287 (rank : 56)	θ value	3.87602e-27 (rank : 143)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	837
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

ULK1_MOUSE
NC score	0.960192 (rank : 57)	θ value	5.22648e-32 (rank : 49)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1214	Shared Neighborhood Hits	861
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

PAK1_HUMAN
NC score	0.959855 (rank : 58)	θ value	3.74554e-30 (rank : 84)
Query Neighborhood Hits	1311	Target Neighborhood Hits	873	Shared Neighborhood Hits	839
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

M3K15_HUMAN
NC score	0.959778 (rank : 59)	θ value	5.40856e-29 (rank : 106)
Query Neighborhood Hits	1311	Target Neighborhood Hits	914	Shared Neighborhood Hits	852
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

PAK3_MOUSE
NC score	0.959761 (rank : 60)	θ value	1.28732e-30 (rank : 78)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	842
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

NUAK1_HUMAN
NC score	0.959604 (rank : 61)	θ value	3.74554e-30 (rank : 83)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	839
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

PAK3_HUMAN
NC score	0.959603 (rank : 62)	θ value	1.28732e-30 (rank : 77)
Query Neighborhood Hits	1311	Target Neighborhood Hits	887	Shared Neighborhood Hits	843
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK1_MOUSE
NC score	0.959412 (rank : 63)	θ value	1.2049e-28 (rank : 111)
Query Neighborhood Hits	1311	Target Neighborhood Hits	878	Shared Neighborhood Hits	841
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

NUAK1_MOUSE
NC score	0.958948 (rank : 64)	θ value	4.89182e-30 (rank : 86)
Query Neighborhood Hits	1311	Target Neighborhood Hits	881	Shared Neighborhood Hits	844
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

STK3_MOUSE
NC score	0.958738 (rank : 65)	θ value	1.08979e-29 (rank : 92)
Query Neighborhood Hits	1311	Target Neighborhood Hits	869	Shared Neighborhood Hits	839
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

HUNK_HUMAN
NC score	0.958721 (rank : 66)	θ value	3.50572e-28 (rank : 124)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	844
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

STK24_HUMAN
NC score	0.958696 (rank : 67)	θ value	5.22648e-32 (rank : 47)
Query Neighborhood Hits	1311	Target Neighborhood Hits	853	Shared Neighborhood Hits	840
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

STK3_HUMAN
NC score	0.958665 (rank : 68)	θ value	6.38894e-30 (rank : 88)
Query Neighborhood Hits	1311	Target Neighborhood Hits	861	Shared Neighborhood Hits	839
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK4_MOUSE
NC score	0.958664 (rank : 69)	θ value	5.40856e-29 (rank : 109)
Query Neighborhood Hits	1311	Target Neighborhood Hits	873	Shared Neighborhood Hits	845
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

STK4_HUMAN
NC score	0.958657 (rank : 70)	θ value	5.40856e-29 (rank : 108)
Query Neighborhood Hits	1311	Target Neighborhood Hits	870	Shared Neighborhood Hits	842
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

M3K5_MOUSE
NC score	0.958532 (rank : 71)	θ value	2.42779e-29 (rank : 101)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	838
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K2_MOUSE
NC score	0.958524 (rank : 72)	θ value	5.59698e-26 (rank : 170)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	831
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

STK11_HUMAN
NC score	0.958515 (rank : 73)	θ value	1.16704e-23 (rank : 246)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	825
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

HUNK_MOUSE
NC score	0.958475 (rank : 74)	θ value	1.73987e-27 (rank : 139)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	840
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

M3K5_HUMAN
NC score	0.958429 (rank : 75)	θ value	1.85889e-29 (rank : 97)
Query Neighborhood Hits	1311	Target Neighborhood Hits	868	Shared Neighborhood Hits	841
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

STK24_MOUSE
NC score	0.958014 (rank : 76)	θ value	8.91499e-32 (rank : 54)
Query Neighborhood Hits	1311	Target Neighborhood Hits	856	Shared Neighborhood Hits	842
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

NUAK2_MOUSE
NC score	0.957879 (rank : 77)	θ value	1.73987e-27 (rank : 140)
Query Neighborhood Hits	1311	Target Neighborhood Hits	878	Shared Neighborhood Hits	843
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

E2AK2_HUMAN
NC score	0.957812 (rank : 78)	θ value	3.28125e-26 (rank : 164)
Query Neighborhood Hits	1311	Target Neighborhood Hits	856	Shared Neighborhood Hits	832
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

NIM1_MOUSE
NC score	0.957600 (rank : 79)	θ value	1.6813e-30 (rank : 80)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	839
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PAK4_MOUSE
NC score	0.957545 (rank : 80)	θ value	5.40856e-29 (rank : 107)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1098	Shared Neighborhood Hits	845
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

NIM1_HUMAN
NC score	0.957520 (rank : 81)	θ value	3.3877e-31 (rank : 65)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	835
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

CHK1_MOUSE
NC score	0.957496 (rank : 82)	θ value	1.02238e-19 (rank : 378)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	831
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

CHK1_HUMAN
NC score	0.957270 (rank : 83)	θ value	2.27762e-19 (rank : 390)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	827
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

MST4_HUMAN
NC score	0.956911 (rank : 84)	θ value	9.8567e-31 (rank : 73)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	839
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

MST4_MOUSE
NC score	0.956884 (rank : 85)	θ value	9.8567e-31 (rank : 74)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	840
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

STK25_HUMAN
NC score	0.956176 (rank : 86)	θ value	8.3442e-30 (rank : 90)
Query Neighborhood Hits	1311	Target Neighborhood Hits	853	Shared Neighborhood Hits	838
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

STK25_MOUSE
NC score	0.955826 (rank : 87)	θ value	3.74554e-30 (rank : 85)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	838
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

OXSR1_HUMAN
NC score	0.955812 (rank : 88)	θ value	5.23862e-24 (rank : 240)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	843
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

OXSR1_MOUSE
NC score	0.955771 (rank : 89)	θ value	2.35151e-24 (rank : 227)
Query Neighborhood Hits	1311	Target Neighborhood Hits	865	Shared Neighborhood Hits	840
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK39_HUMAN
NC score	0.955454 (rank : 90)	θ value	9.87957e-23 (rank : 285)
Query Neighborhood Hits	1311	Target Neighborhood Hits	882	Shared Neighborhood Hits	845
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
NC score	0.955364 (rank : 91)	θ value	9.87957e-23 (rank : 286)
Query Neighborhood Hits	1311	Target Neighborhood Hits	915	Shared Neighborhood Hits	853
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

MARK4_HUMAN
NC score	0.955339 (rank : 92)	θ value	5.22648e-32 (rank : 45)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	843
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
NC score	0.955244 (rank : 93)	θ value	5.22648e-32 (rank : 46)
Query Neighborhood Hits	1311	Target Neighborhood Hits	898	Shared Neighborhood Hits	844
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

TSSK4_MOUSE
NC score	0.955232 (rank : 94)	θ value	6.84181e-24 (rank : 242)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

AAPK1_HUMAN
NC score	0.955201 (rank : 95)	θ value	1.24688e-25 (rank : 175)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	837
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
NC score	0.954986 (rank : 96)	θ value	1.24688e-25 (rank : 176)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	837
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

KKCC2_MOUSE
NC score	0.954599 (rank : 97)	θ value	1.42661e-21 (rank : 316)
Query Neighborhood Hits	1311	Target Neighborhood Hits	855	Shared Neighborhood Hits	831
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_HUMAN
NC score	0.954535 (rank : 98)	θ value	1.42661e-21 (rank : 315)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	830
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

MARK3_MOUSE
NC score	0.953939 (rank : 99)	θ value	4.72714e-33 (rank : 38)
Query Neighborhood Hits	1311	Target Neighborhood Hits	919	Shared Neighborhood Hits	844
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

SN1L1_MOUSE
NC score	0.953120 (rank : 100)	θ value	6.61148e-27 (rank : 149)
Query Neighborhood Hits	1311	Target Neighborhood Hits	895	Shared Neighborhood Hits	840
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

MARK1_MOUSE
NC score	0.952908 (rank : 101)	θ value	6.17384e-33 (rank : 39)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	842
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK1_HUMAN
NC score	0.952905 (rank : 102)	θ value	1.0531e-32 (rank : 41)
Query Neighborhood Hits	1311	Target Neighborhood Hits	887	Shared Neighborhood Hits	844
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

AAPK2_HUMAN
NC score	0.952835 (rank : 103)	θ value	1.5242e-23 (rank : 247)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	836
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

PDPK1_MOUSE
NC score	0.952482 (rank : 104)	θ value	2.68423e-28 (rank : 119)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	836
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PDPK1_HUMAN
NC score	0.952456 (rank : 105)	θ value	2.68423e-28 (rank : 118)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	836
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

TSSK4_HUMAN
NC score	0.952397 (rank : 106)	θ value	1.99067e-23 (rank : 260)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	833
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

ST17B_MOUSE
NC score	0.952362 (rank : 107)	θ value	1.37858e-24 (rank : 222)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	828
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MARK2_HUMAN
NC score	0.952340 (rank : 108)	θ value	1.16434e-31 (rank : 57)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1056	Shared Neighborhood Hits	866
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

DCAK3_MOUSE
NC score	0.952046 (rank : 109)	θ value	2.42779e-29 (rank : 99)
Query Neighborhood Hits	1311	Target Neighborhood Hits	922	Shared Neighborhood Hits	855
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

DCAK3_HUMAN
NC score	0.952035 (rank : 110)	θ value	4.14116e-29 (rank : 102)
Query Neighborhood Hits	1311	Target Neighborhood Hits	888	Shared Neighborhood Hits	845
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

BRSK1_HUMAN
NC score	0.951701 (rank : 111)	θ value	2.96777e-27 (rank : 141)
Query Neighborhood Hits	1311	Target Neighborhood Hits	942	Shared Neighborhood Hits	836
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

KKCC1_MOUSE
NC score	0.951360 (rank : 112)	θ value	1.42661e-21 (rank : 314)
Query Neighborhood Hits	1311	Target Neighborhood Hits	866	Shared Neighborhood Hits	836
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

SN1L1_HUMAN
NC score	0.951245 (rank : 113)	θ value	3.28125e-26 (rank : 166)
Query Neighborhood Hits	1311	Target Neighborhood Hits	911	Shared Neighborhood Hits	842
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

MARK2_MOUSE
NC score	0.951200 (rank : 114)	θ value	9.8567e-31 (rank : 72)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1018	Shared Neighborhood Hits	860
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

BRSK2_HUMAN
NC score	0.951096 (rank : 115)	θ value	1.62847e-25 (rank : 184)
Query Neighborhood Hits	1311	Target Neighborhood Hits	897	Shared Neighborhood Hits	835
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

IKKA_MOUSE
NC score	0.951063 (rank : 116)	θ value	1.42661e-21 (rank : 313)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	840
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

SNRK_HUMAN
NC score	0.950887 (rank : 117)	θ value	6.18819e-25 (rank : 206)
Query Neighborhood Hits	1311	Target Neighborhood Hits	855	Shared Neighborhood Hits	823
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

KKCC1_HUMAN
NC score	0.950845 (rank : 118)	θ value	3.51386e-20 (rank : 364)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	836
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

IKKB_HUMAN
NC score	0.950702 (rank : 119)	θ value	2.69047e-20 (rank : 361)
Query Neighborhood Hits	1311	Target Neighborhood Hits	980	Shared Neighborhood Hits	886
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

PRKY_HUMAN
NC score	0.950425 (rank : 120)	θ value	7.30988e-26 (rank : 172)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	835
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

IKKA_HUMAN
NC score	0.950371 (rank : 121)	θ value	1.86321e-21 (rank : 324)
Query Neighborhood Hits	1311	Target Neighborhood Hits	863	Shared Neighborhood Hits	843
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

SNRK_MOUSE
NC score	0.950323 (rank : 122)	θ value	6.18819e-25 (rank : 207)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	820
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

MELK_MOUSE
NC score	0.949444 (rank : 123)	θ value	1.5242e-23 (rank : 254)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	833
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

M4K3_HUMAN
NC score	0.949069 (rank : 124)	θ value	6.38894e-30 (rank : 87)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

IKKB_MOUSE
NC score	0.948757 (rank : 125)	θ value	1.74391e-19 (rank : 389)
Query Neighborhood Hits	1311	Target Neighborhood Hits	984	Shared Neighborhood Hits	889
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

SN1L2_HUMAN
NC score	0.948594 (rank : 126)	θ value	1.37858e-24 (rank : 221)
Query Neighborhood Hits	1311	Target Neighborhood Hits	964	Shared Neighborhood Hits	853
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

MARK3_HUMAN
NC score	0.948300 (rank : 127)	θ value	2.86786e-30 (rank : 81)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	834
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

SN1L2_MOUSE
NC score	0.948264 (rank : 128)	θ value	4.73814e-25 (rank : 202)
Query Neighborhood Hits	1311	Target Neighborhood Hits	944	Shared Neighborhood Hits	844
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

MELK_HUMAN
NC score	0.948252 (rank : 129)	θ value	1.99067e-23 (rank : 257)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	834
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

ST17B_HUMAN
NC score	0.948177 (rank : 130)	θ value	1.5242e-23 (rank : 256)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	823
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

MP2K2_HUMAN
NC score	0.948041 (rank : 131)	θ value	4.02038e-16 (rank : 506)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

ST32A_MOUSE
NC score	0.947915 (rank : 132)	θ value	2.51237e-26 (rank : 160)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	826
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

KCC1A_MOUSE
NC score	0.947738 (rank : 133)	θ value	5.40856e-29 (rank : 105)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	836
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

DAPK3_MOUSE
NC score	0.947702 (rank : 134)	θ value	4.9032e-22 (rank : 301)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

KCC1A_HUMAN
NC score	0.947616 (rank : 135)	θ value	5.40856e-29 (rank : 104)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	836
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

TSSK1_MOUSE
NC score	0.947489 (rank : 136)	θ value	1.24688e-25 (rank : 183)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	822
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK6_MOUSE
NC score	0.947428 (rank : 137)	θ value	2.51237e-26 (rank : 162)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	820
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

M4K1_HUMAN
NC score	0.947203 (rank : 138)	θ value	8.63488e-27 (rank : 152)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	836
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

M4K2_MOUSE
NC score	0.947029 (rank : 139)	θ value	7.54701e-31 (rank : 69)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	828
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

KCC1G_MOUSE
NC score	0.947000 (rank : 140)	θ value	1.92365e-26 (rank : 159)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	835
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

K0999_HUMAN
NC score	0.946913 (rank : 141)	θ value	2.77775e-25 (rank : 195)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	833
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MP2K2_MOUSE
NC score	0.946835 (rank : 142)	θ value	1.80466e-16 (rank : 489)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	824
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

M4K1_MOUSE
NC score	0.946834 (rank : 143)	θ value	4.01107e-24 (rank : 236)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	836
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

KCC1G_HUMAN
NC score	0.946827 (rank : 144)	θ value	3.28125e-26 (rank : 165)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	835
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

K0999_MOUSE
NC score	0.946721 (rank : 145)	θ value	1.24688e-25 (rank : 177)
Query Neighborhood Hits	1311	Target Neighborhood Hits	931	Shared Neighborhood Hits	838
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MP2K1_HUMAN
NC score	0.946718 (rank : 146)	θ value	1.80466e-16 (rank : 487)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	822
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

MP2K1_MOUSE
NC score	0.946672 (rank : 147)	θ value	1.80466e-16 (rank : 488)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	822
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

DAPK3_HUMAN
NC score	0.946506 (rank : 148)	θ value	1.29031e-22 (rank : 290)
Query Neighborhood Hits	1311	Target Neighborhood Hits	945	Shared Neighborhood Hits	862
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

TSSK6_HUMAN
NC score	0.946494 (rank : 149)	θ value	1.62847e-25 (rank : 192)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	821
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

ST17A_HUMAN
NC score	0.946407 (rank : 150)	θ value	9.87957e-23 (rank : 284)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	825
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

MYLK2_HUMAN
NC score	0.946267 (rank : 151)	θ value	7.56453e-23 (rank : 277)
Query Neighborhood Hits	1311	Target Neighborhood Hits	920	Shared Neighborhood Hits	820
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

M4K2_HUMAN
NC score	0.946238 (rank : 152)	θ value	4.42448e-31 (rank : 67)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	827
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

MP2K5_MOUSE
NC score	0.945935 (rank : 153)	θ value	3.40345e-15 (rank : 545)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

KPSH1_MOUSE
NC score	0.945676 (rank : 154)	θ value	1.12775e-26 (rank : 154)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	830
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

DAPK2_MOUSE
NC score	0.945607 (rank : 155)	θ value	1.5773e-20 (rank : 351)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	827
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

ST32A_HUMAN
NC score	0.945255 (rank : 156)	θ value	4.73814e-25 (rank : 203)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	826
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

CHK2_MOUSE
NC score	0.945244 (rank : 157)	θ value	1.5242e-23 (rank : 249)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

KPSH1_HUMAN
NC score	0.945200 (rank : 158)	θ value	1.12775e-26 (rank : 153)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	830
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

CDKL3_HUMAN
NC score	0.945175 (rank : 159)	θ value	1.5242e-23 (rank : 248)
Query Neighborhood Hits	1311	Target Neighborhood Hits	853	Shared Neighborhood Hits	836
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

KCC1B_MOUSE
NC score	0.945154 (rank : 160)	θ value	3.62785e-25 (rank : 200)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	836
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

STK16_HUMAN
NC score	0.945003 (rank : 161)	θ value	2.59989e-23 (rank : 267)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	822
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

CDKL3_MOUSE
NC score	0.944845 (rank : 162)	θ value	8.93572e-24 (rank : 243)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	834
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

KS6A2_MOUSE
NC score	0.944714 (rank : 163)	θ value	8.61488e-35 (rank : 23)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	844
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KCC1B_HUMAN
NC score	0.944712 (rank : 164)	θ value	6.18819e-25 (rank : 204)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	836
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

TSSK2_HUMAN
NC score	0.944610 (rank : 165)	θ value	9.87957e-23 (rank : 287)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

CHK2_HUMAN
NC score	0.944511 (rank : 166)	θ value	5.23862e-24 (rank : 238)
Query Neighborhood Hits	1311	Target Neighborhood Hits	859	Shared Neighborhood Hits	830
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

KS6A1_HUMAN
NC score	0.944479 (rank : 167)	θ value	8.61488e-35 (rank : 21)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	843
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

KS6A2_HUMAN
NC score	0.944308 (rank : 168)	θ value	8.61488e-35 (rank : 22)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	842
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

PHKG2_MOUSE
NC score	0.944291 (rank : 169)	θ value	1.2077e-20 (rank : 347)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	832
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PDK1L_HUMAN
NC score	0.943805 (rank : 170)	θ value	1.29331e-14 (rank : 563)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	814
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

KCC1D_MOUSE
NC score	0.943797 (rank : 171)	θ value	1.24688e-25 (rank : 179)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	834
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.943781 (rank : 172)	θ value	1.24688e-25 (rank : 178)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	834
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

PDK1L_MOUSE
NC score	0.943677 (rank : 173)	θ value	1.29331e-14 (rank : 564)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	815
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

STK16_MOUSE
NC score	0.943556 (rank : 174)	θ value	3.07116e-24 (rank : 234)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	817
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

KPSH2_HUMAN
NC score	0.943426 (rank : 175)	θ value	2.87452e-22 (rank : 298)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	816
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KS6A3_HUMAN
NC score	0.943180 (rank : 176)	θ value	1.12514e-34 (rank : 25)
Query Neighborhood Hits	1311	Target Neighborhood Hits	859	Shared Neighborhood Hits	844
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
NC score	0.943167 (rank : 177)	θ value	1.12514e-34 (rank : 26)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	844
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KAPCG_HUMAN
NC score	0.942862 (rank : 178)	θ value	1.6247e-33 (rank : 36)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	836
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

DAPK2_HUMAN
NC score	0.942647 (rank : 179)	θ value	1.33526e-19 (rank : 384)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	825
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

KS6A6_HUMAN
NC score	0.942391 (rank : 180)	θ value	9.52487e-34 (rank : 32)
Query Neighborhood Hits	1311	Target Neighborhood Hits	853	Shared Neighborhood Hits	841
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

KCC2G_MOUSE
NC score	0.942385 (rank : 181)	θ value	3.3877e-31 (rank : 64)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	824
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KPCD2_HUMAN
NC score	0.942379 (rank : 182)	θ value	4.57862e-28 (rank : 127)
Query Neighborhood Hits	1311	Target Neighborhood Hits	910	Shared Neighborhood Hits	835
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

KCC2G_HUMAN
NC score	0.942372 (rank : 183)	θ value	3.3877e-31 (rank : 63)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	824
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

PASK_MOUSE
NC score	0.942298 (rank : 184)	θ value	5.07402e-19 (rank : 406)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	825
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

PRKX_HUMAN
NC score	0.942092 (rank : 185)	θ value	6.61148e-27 (rank : 148)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	835
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PHKG2_HUMAN
NC score	0.941977 (rank : 186)	θ value	5.99374e-20 (rank : 375)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	832
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

ST32B_MOUSE
NC score	0.941788 (rank : 187)	θ value	1.05554e-24 (rank : 217)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	821
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

MP2K7_HUMAN
NC score	0.941657 (rank : 188)	θ value	4.02038e-16 (rank : 507)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	822
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

M4K5_MOUSE
NC score	0.941394 (rank : 189)	θ value	2.96777e-27 (rank : 142)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	823
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

KS6B1_MOUSE
NC score	0.941306 (rank : 190)	θ value	5.22648e-32 (rank : 44)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	832
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

KS6B1_HUMAN
NC score	0.941286 (rank : 191)	θ value	5.22648e-32 (rank : 43)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	833
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

SBK1_MOUSE
NC score	0.941177 (rank : 192)	θ value	4.44505e-15 (rank : 548)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	804
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

PRKX_MOUSE
NC score	0.941127 (rank : 193)	θ value	2.35151e-24 (rank : 229)
Query Neighborhood Hits	1311	Target Neighborhood Hits	846	Shared Neighborhood Hits	838
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

MP2K5_HUMAN
NC score	0.940978 (rank : 194)	θ value	2.20605e-14 (rank : 571)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	827
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

ST32B_HUMAN
NC score	0.940864 (rank : 195)	θ value	5.23862e-24 (rank : 241)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

TAOK2_HUMAN
NC score	0.940809 (rank : 196)	θ value	1.57365e-28 (rank : 114)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1172	Shared Neighborhood Hits	955
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

KCC2A_HUMAN
NC score	0.940658 (rank : 197)	θ value	1.28732e-30 (rank : 76)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	821
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC4_HUMAN
NC score	0.940551 (rank : 198)	θ value	4.43474e-23 (rank : 270)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	827
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KPCD1_HUMAN
NC score	0.940550 (rank : 199)	θ value	7.80994e-28 (rank : 132)
Query Neighborhood Hits	1311	Target Neighborhood Hits	901	Shared Neighborhood Hits	833
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KCC4_MOUSE
NC score	0.940172 (rank : 200)	θ value	4.43474e-23 (rank : 271)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	849
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

ST32C_MOUSE
NC score	0.940155 (rank : 201)	θ value	2.77775e-25 (rank : 198)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	815
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

KCC2D_HUMAN
NC score	0.940148 (rank : 202)	θ value	9.8567e-31 (rank : 71)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KPCD1_MOUSE
NC score	0.940121 (rank : 203)	θ value	1.33217e-27 (rank : 136)
Query Neighborhood Hits	1311	Target Neighborhood Hits	891	Shared Neighborhood Hits	834
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

M4K5_HUMAN
NC score	0.940076 (rank : 204)	θ value	1.02001e-27 (rank : 135)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	827
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

CDKL4_MOUSE
NC score	0.939884 (rank : 205)	θ value	1.05554e-24 (rank : 214)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	827
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

KS6B2_HUMAN
NC score	0.939598 (rank : 206)	θ value	1.6247e-33 (rank : 37)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	834
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

STK35_HUMAN
NC score	0.939194 (rank : 207)	θ value	7.09661e-13 (rank : 607)
Query Neighborhood Hits	1311	Target Neighborhood Hits	825	Shared Neighborhood Hits	815
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

KS6A1_MOUSE
NC score	0.939174 (rank : 208)	θ value	2.59387e-31 (rank : 61)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	840
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

PHKG1_HUMAN
NC score	0.938957 (rank : 209)	θ value	5.99374e-20 (rank : 374)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	830
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

SBK1_HUMAN
NC score	0.938876 (rank : 210)	θ value	5.8054e-15 (rank : 555)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	806
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

KCC2A_MOUSE
NC score	0.938776 (rank : 211)	θ value	2.42779e-29 (rank : 100)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	819
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

CDKL2_MOUSE
NC score	0.938624 (rank : 212)	θ value	1.42661e-21 (rank : 312)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	835
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

KCC2B_HUMAN
NC score	0.938323 (rank : 213)	θ value	1.85889e-29 (rank : 95)
Query Neighborhood Hits	1311	Target Neighborhood Hits	866	Shared Neighborhood Hits	822
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

MP2K4_MOUSE
NC score	0.938304 (rank : 214)	θ value	6.85773e-16 (rank : 518)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	826
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K3_MOUSE
NC score	0.938291 (rank : 215)	θ value	5.99374e-20 (rank : 373)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	819
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MP2K4_HUMAN
NC score	0.938251 (rank : 216)	θ value	6.85773e-16 (rank : 517)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	826
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

PHKG1_MOUSE
NC score	0.938072 (rank : 217)	θ value	4.15078e-21 (rank : 336)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	829
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

TSSK1_HUMAN
NC score	0.937944 (rank : 218)	θ value	6.18819e-25 (rank : 208)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	815
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

SGK1_HUMAN
NC score	0.937784 (rank : 219)	θ value	3.50572e-28 (rank : 125)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	834
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

PASK_HUMAN
NC score	0.937699 (rank : 220)	θ value	7.82807e-20 (rank : 377)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	815
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

KAPCA_MOUSE
NC score	0.937679 (rank : 221)	θ value	1.24399e-33 (rank : 34)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	831
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KAPCA_HUMAN
NC score	0.937618 (rank : 222)	θ value	1.24399e-33 (rank : 33)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	831
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

MP2K3_HUMAN
NC score	0.937495 (rank : 223)	θ value	1.33526e-19 (rank : 386)
Query Neighborhood Hits	1311	Target Neighborhood Hits	825	Shared Neighborhood Hits	819
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

ST32C_HUMAN
NC score	0.937407 (rank : 224)	θ value	8.08199e-25 (rank : 211)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	818
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

SGK1_MOUSE
NC score	0.937333 (rank : 225)	θ value	5.97985e-28 (rank : 128)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	834
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

CDKL2_HUMAN
NC score	0.937295 (rank : 226)	θ value	3.17815e-21 (rank : 329)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	827
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

CDC2_HUMAN
NC score	0.936863 (rank : 227)	θ value	3.62785e-25 (rank : 199)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	836
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

KS6B2_MOUSE
NC score	0.936844 (rank : 228)	θ value	5.584e-34 (rank : 30)
Query Neighborhood Hits	1311	Target Neighborhood Hits	871	Shared Neighborhood Hits	831
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

KPCD3_HUMAN
NC score	0.936740 (rank : 229)	θ value	1.24688e-25 (rank : 180)
Query Neighborhood Hits	1311	Target Neighborhood Hits	895	Shared Neighborhood Hits	828
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

KCC2B_MOUSE
NC score	0.936577 (rank : 230)	θ value	1.85889e-29 (rank : 96)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	822
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

TSSK3_MOUSE
NC score	0.936473 (rank : 231)	θ value	7.56453e-23 (rank : 279)
Query Neighborhood Hits	1311	Target Neighborhood Hits	806	Shared Neighborhood Hits	802
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

KPCD3_MOUSE
NC score	0.936432 (rank : 232)	θ value	1.24688e-25 (rank : 181)
Query Neighborhood Hits	1311	Target Neighborhood Hits	901	Shared Neighborhood Hits	828
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

CDKL1_HUMAN
NC score	0.936200 (rank : 233)	θ value	4.28545e-26 (rank : 167)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	826
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

TSSK2_MOUSE
NC score	0.936181 (rank : 234)	θ value	3.75424e-22 (rank : 300)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	811
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

AKT3_HUMAN
NC score	0.936121 (rank : 235)	θ value	8.91499e-32 (rank : 52)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.936104 (rank : 236)	θ value	8.91499e-32 (rank : 53)
Query Neighborhood Hits	1311	Target Neighborhood Hits	872	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

SGK2_MOUSE
NC score	0.936012 (rank : 237)	θ value	9.2256e-29 (rank : 110)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	829
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

CDC2_MOUSE
NC score	0.935969 (rank : 238)	θ value	1.62847e-25 (rank : 185)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	835
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

IKKE_HUMAN
NC score	0.935872 (rank : 239)	θ value	2.43908e-13 (rank : 591)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	815
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

KAPCB_HUMAN
NC score	0.935778 (rank : 240)	θ value	1.28732e-30 (rank : 75)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	830
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

TSSK3_HUMAN
NC score	0.935773 (rank : 241)	θ value	2.20094e-22 (rank : 296)
Query Neighborhood Hits	1311	Target Neighborhood Hits	806	Shared Neighborhood Hits	803
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

CDKL4_HUMAN
NC score	0.935714 (rank : 242)	θ value	3.39556e-23 (rank : 268)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	822
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

DCAK1_MOUSE
NC score	0.935677 (rank : 243)	θ value	1.62847e-25 (rank : 186)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	830
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

CDKL1_MOUSE
NC score	0.935643 (rank : 244)	θ value	2.12685e-25 (rank : 193)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	825
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

DCAK1_HUMAN
NC score	0.935639 (rank : 245)	θ value	8.08199e-25 (rank : 209)
Query Neighborhood Hits	1311	Target Neighborhood Hits	877	Shared Neighborhood Hits	833
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

PMYT1_MOUSE
NC score	0.935610 (rank : 246)	θ value	7.30988e-26 (rank : 171)
Query Neighborhood Hits	1311	Target Neighborhood Hits	910	Shared Neighborhood Hits	826
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KAPCB_MOUSE
NC score	0.935542 (rank : 247)	θ value	4.42448e-31 (rank : 66)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	830
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

ULK4_MOUSE
NC score	0.935423 (rank : 248)	θ value	8.36355e-22 (rank : 310)
Query Neighborhood Hits	1311	Target Neighborhood Hits	793	Shared Neighborhood Hits	778
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

DCAK2_MOUSE
NC score	0.935169 (rank : 249)	θ value	3.28125e-26 (rank : 163)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	829
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

SGK2_HUMAN
NC score	0.934955 (rank : 250)	θ value	2.68423e-28 (rank : 120)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	831
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

MP2K6_MOUSE
NC score	0.934759 (rank : 251)	θ value	3.28887e-18 (rank : 427)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	823
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

AKT2_HUMAN
NC score	0.934603 (rank : 252)	θ value	6.82597e-32 (rank : 50)
Query Neighborhood Hits	1311	Target Neighborhood Hits	878	Shared Neighborhood Hits	829
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

MP2K6_HUMAN
NC score	0.934455 (rank : 253)	θ value	7.32683e-18 (rank : 438)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	822
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

AKT2_MOUSE
NC score	0.934263 (rank : 254)	θ value	6.82597e-32 (rank : 51)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	829
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

M3K14_HUMAN
NC score	0.934098 (rank : 255)	θ value	2.88119e-14 (rank : 574)
Query Neighborhood Hits	1311	Target Neighborhood Hits	887	Shared Neighborhood Hits	812
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

DCAK2_HUMAN
NC score	0.933846 (rank : 256)	θ value	1.92365e-26 (rank : 158)
Query Neighborhood Hits	1311	Target Neighborhood Hits	862	Shared Neighborhood Hits	827
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

IKKE_MOUSE
NC score	0.933708 (rank : 257)	θ value	1.02475e-11 (rank : 635)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	821
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

ICK_MOUSE
NC score	0.933654 (rank : 258)	θ value	1.62847e-25 (rank : 187)
Query Neighborhood Hits	1311	Target Neighborhood Hits	860	Shared Neighborhood Hits	834
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

CDKL5_HUMAN
NC score	0.933614 (rank : 259)	θ value	1.16704e-23 (rank : 245)
Query Neighborhood Hits	1311	Target Neighborhood Hits	967	Shared Neighborhood Hits	854
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

SLK_MOUSE
NC score	0.933035 (rank : 260)	θ value	2.59387e-31 (rank : 62)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1798	Shared Neighborhood Hits	1076
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

CDK2_HUMAN
NC score	0.932992 (rank : 261)	θ value	5.59698e-26 (rank : 169)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	830
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

ICK_HUMAN
NC score	0.932856 (rank : 262)	θ value	1.80048e-24 (rank : 223)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	833
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

CDK3_HUMAN
NC score	0.932711 (rank : 263)	θ value	1.92365e-26 (rank : 157)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	834
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

CDK2_MOUSE
NC score	0.932533 (rank : 264)	θ value	4.73814e-25 (rank : 201)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	825
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

CDK3_MOUSE
NC score	0.932517 (rank : 265)	θ value	3.63628e-17 (rank : 460)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	825
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

KS6A5_HUMAN
NC score	0.932147 (rank : 266)	θ value	1.05554e-24 (rank : 216)
Query Neighborhood Hits	1311	Target Neighborhood Hits	855	Shared Neighborhood Hits	839
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

MINK1_MOUSE
NC score	0.932115 (rank : 267)	θ value	1.62847e-25 (rank : 190)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1451	Shared Neighborhood Hits	962
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

PKN2_MOUSE
NC score	0.931936 (rank : 268)	θ value	9.87957e-23 (rank : 283)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	850
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_HUMAN
NC score	0.931809 (rank : 269)	θ value	9.87957e-23 (rank : 282)
Query Neighborhood Hits	1311	Target Neighborhood Hits	892	Shared Neighborhood Hits	846
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

TNIK_HUMAN
NC score	0.931587 (rank : 270)	θ value	2.51237e-26 (rank : 161)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1570	Shared Neighborhood Hits	980
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

MINK1_HUMAN
NC score	0.931418 (rank : 271)	θ value	1.62847e-25 (rank : 189)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1477	Shared Neighborhood Hits	964
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

SLK_HUMAN
NC score	0.931386 (rank : 272)	θ value	1.52067e-31 (rank : 58)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1775	Shared Neighborhood Hits	1062
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

M3K13_HUMAN
NC score	0.931310 (rank : 273)	θ value	4.28545e-26 (rank : 168)
Query Neighborhood Hits	1311	Target Neighborhood Hits	911	Shared Neighborhood Hits	843
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

SGK3_MOUSE
NC score	0.930996 (rank : 274)	θ value	4.42448e-31 (rank : 68)
Query Neighborhood Hits	1311	Target Neighborhood Hits	882	Shared Neighborhood Hits	827
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

AKT1_HUMAN
NC score	0.930959 (rank : 275)	θ value	1.98606e-31 (rank : 59)
Query Neighborhood Hits	1311	Target Neighborhood Hits	885	Shared Neighborhood Hits	830
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
NC score	0.930881 (rank : 276)	θ value	1.98606e-31 (rank : 60)
Query Neighborhood Hits	1311	Target Neighborhood Hits	878	Shared Neighborhood Hits	830
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

MAK_MOUSE
NC score	0.930827 (rank : 277)	θ value	9.87957e-23 (rank : 280)
Query Neighborhood Hits	1311	Target Neighborhood Hits	873	Shared Neighborhood Hits	833
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

M3K8_HUMAN
NC score	0.930704 (rank : 278)	θ value	2.20605e-14 (rank : 570)
Query Neighborhood Hits	1311	Target Neighborhood Hits	807	Shared Neighborhood Hits	800
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

SGK3_HUMAN
NC score	0.930537 (rank : 279)	θ value	1.28732e-30 (rank : 79)
Query Neighborhood Hits	1311	Target Neighborhood Hits	877	Shared Neighborhood Hits	827
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

M3K8_MOUSE
NC score	0.930497 (rank : 280)	θ value	3.40345e-15 (rank : 544)
Query Neighborhood Hits	1311	Target Neighborhood Hits	815	Shared Neighborhood Hits	802
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

RK_MOUSE
NC score	0.930458 (rank : 281)	θ value	7.56453e-23 (rank : 278)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	821
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

NRK_MOUSE
NC score	0.930430 (rank : 282)	θ value	1.47631e-18 (rank : 419)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	844
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

NRK_HUMAN
NC score	0.930316 (rank : 283)	θ value	5.07402e-19 (rank : 405)
Query Neighborhood Hits	1311	Target Neighborhood Hits	931	Shared Neighborhood Hits	850
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

PKN1_MOUSE
NC score	0.930161 (rank : 284)	θ value	1.99067e-23 (rank : 259)
Query Neighborhood Hits	1311	Target Neighborhood Hits	888	Shared Neighborhood Hits	840
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

PKN1_HUMAN
NC score	0.929738 (rank : 285)	θ value	1.5242e-23 (rank : 255)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	845
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

KPCT_HUMAN
NC score	0.929680 (rank : 286)	θ value	4.01107e-24 (rank : 235)
Query Neighborhood Hits	1311	Target Neighborhood Hits	897	Shared Neighborhood Hits	835
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

TAOK2_MOUSE
NC score	0.929502 (rank : 287)	θ value	1.2049e-28 (rank : 113)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1373	Shared Neighborhood Hits	992
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

MAK_HUMAN
NC score	0.929474 (rank : 288)	θ value	2.87452e-22 (rank : 299)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	831
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PMYT1_HUMAN
NC score	0.929439 (rank : 289)	θ value	2.35151e-24 (rank : 228)
Query Neighborhood Hits	1311	Target Neighborhood Hits	814	Shared Neighborhood Hits	802
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

KS6A4_MOUSE
NC score	0.929015 (rank : 290)	θ value	5.23862e-24 (rank : 239)
Query Neighborhood Hits	1311	Target Neighborhood Hits	866	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

RK_HUMAN
NC score	0.928912 (rank : 291)	θ value	1.6852e-22 (rank : 294)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KPCT_MOUSE
NC score	0.928708 (rank : 292)	θ value	7.56453e-23 (rank : 275)
Query Neighborhood Hits	1311	Target Neighborhood Hits	895	Shared Neighborhood Hits	832
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

CDK7_MOUSE
NC score	0.928673 (rank : 293)	θ value	1.33526e-19 (rank : 383)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

KS6A4_HUMAN
NC score	0.928564 (rank : 294)	θ value	2.35151e-24 (rank : 226)
Query Neighborhood Hits	1311	Target Neighborhood Hits	868	Shared Neighborhood Hits	842
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

M3K14_MOUSE
NC score	0.928443 (rank : 295)	θ value	1.80466e-16 (rank : 486)
Query Neighborhood Hits	1311	Target Neighborhood Hits	889	Shared Neighborhood Hits	806
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

CDK7_HUMAN
NC score	0.928184 (rank : 296)	θ value	5.99374e-20 (rank : 371)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	823
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

KS6A5_MOUSE
NC score	0.928045 (rank : 297)	θ value	6.18819e-25 (rank : 205)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	837
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

MAPK2_HUMAN
NC score	0.927971 (rank : 298)	θ value	2.5182e-18 (rank : 423)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	820
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

E2AK3_HUMAN
NC score	0.927957 (rank : 299)	θ value	2.20605e-14 (rank : 569)
Query Neighborhood Hits	1311	Target Neighborhood Hits	859	Shared Neighborhood Hits	828
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

TBK1_HUMAN
NC score	0.927921 (rank : 300)	θ value	2.28291e-11 (rank : 650)
Query Neighborhood Hits	1311	Target Neighborhood Hits	861	Shared Neighborhood Hits	818
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TBK1_MOUSE
NC score	0.927806 (rank : 301)	θ value	1.33837e-11 (rank : 643)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	832
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

E2AK3_MOUSE
NC score	0.927742 (rank : 302)	θ value	1.99529e-15 (rank : 534)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	832
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

MAPK2_MOUSE
NC score	0.926858 (rank : 303)	θ value	3.28887e-18 (rank : 426)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	817
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

CDK6_MOUSE
NC score	0.926569 (rank : 304)	θ value	3.51386e-20 (rank : 363)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	830
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

PKN3_MOUSE
NC score	0.926293 (rank : 305)	θ value	4.43474e-23 (rank : 274)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	856
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PKN3_HUMAN
NC score	0.926100 (rank : 306)	θ value	4.9032e-22 (rank : 302)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	836
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

GRK6_HUMAN
NC score	0.925651 (rank : 307)	θ value	4.43474e-23 (rank : 269)
Query Neighborhood Hits	1311	Target Neighborhood Hits	823	Shared Neighborhood Hits	821
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MAPK3_MOUSE
NC score	0.925451 (rank : 308)	θ value	5.07402e-19 (rank : 404)
Query Neighborhood Hits	1311	Target Neighborhood Hits	811	Shared Neighborhood Hits	806
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

CDK6_HUMAN
NC score	0.925426 (rank : 309)	θ value	5.99374e-20 (rank : 370)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	830
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

PFTK1_MOUSE
NC score	0.925332 (rank : 310)	θ value	2.97466e-19 (rank : 397)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	823
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_HUMAN
NC score	0.925266 (rank : 311)	θ value	2.27762e-19 (rank : 392)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	821
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

MASTL_MOUSE
NC score	0.925213 (rank : 312)	θ value	2.60593e-15 (rank : 539)
Query Neighborhood Hits	1311	Target Neighborhood Hits	862	Shared Neighborhood Hits	835
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

GRK6_MOUSE
NC score	0.924938 (rank : 313)	θ value	2.59989e-23 (rank : 264)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	820
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

MASTL_HUMAN
NC score	0.924886 (rank : 314)	θ value	4.44505e-15 (rank : 547)
Query Neighborhood Hits	1311	Target Neighborhood Hits	894	Shared Neighborhood Hits	841
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

M3K12_HUMAN
NC score	0.924434 (rank : 315)	θ value	9.54697e-26 (rank : 173)
Query Neighborhood Hits	1311	Target Neighborhood Hits	940	Shared Neighborhood Hits	847
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.924398 (rank : 316)	θ value	9.54697e-26 (rank : 174)
Query Neighborhood Hits	1311	Target Neighborhood Hits	957	Shared Neighborhood Hits	851
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

PCTK3_MOUSE
NC score	0.924288 (rank : 317)	θ value	4.43474e-23 (rank : 273)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	822
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

KGP2_HUMAN
NC score	0.923618 (rank : 318)	θ value	2.87452e-22 (rank : 297)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1023	Shared Neighborhood Hits	878
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

CDK5_HUMAN
NC score	0.923209 (rank : 319)	θ value	1.05554e-24 (rank : 212)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	820
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
NC score	0.923162 (rank : 320)	θ value	1.05554e-24 (rank : 213)
Query Neighborhood Hits	1311	Target Neighborhood Hits	826	Shared Neighborhood Hits	820
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

KGP2_MOUSE
NC score	0.923153 (rank : 321)	θ value	2.20094e-22 (rank : 295)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1029	Shared Neighborhood Hits	876
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

TTK_HUMAN
NC score	0.922877 (rank : 322)	θ value	1.29331e-14 (rank : 565)
Query Neighborhood Hits	1311	Target Neighborhood Hits	816	Shared Neighborhood Hits	781
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

PCTK1_MOUSE
NC score	0.922672 (rank : 323)	θ value	5.42112e-21 (rank : 338)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	820
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK1_HUMAN
NC score	0.922416 (rank : 324)	θ value	4.15078e-21 (rank : 335)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	822
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

KPCD_HUMAN
NC score	0.922163 (rank : 325)	θ value	9.24701e-21 (rank : 344)
Query Neighborhood Hits	1311	Target Neighborhood Hits	900	Shared Neighborhood Hits	835
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

WNK3_HUMAN
NC score	0.922137 (rank : 326)	θ value	1.42661e-21 (rank : 321)
Query Neighborhood Hits	1311	Target Neighborhood Hits	948	Shared Neighborhood Hits	783
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

KPCI_HUMAN
NC score	0.922093 (rank : 327)	θ value	1.5242e-23 (rank : 252)
Query Neighborhood Hits	1311	Target Neighborhood Hits	885	Shared Neighborhood Hits	834
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

MAPK3_HUMAN
NC score	0.922005 (rank : 328)	θ value	9.56915e-18 (rank : 440)
Query Neighborhood Hits	1311	Target Neighborhood Hits	807	Shared Neighborhood Hits	796
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

KPCI_MOUSE
NC score	0.921944 (rank : 329)	θ value	1.5242e-23 (rank : 253)
Query Neighborhood Hits	1311	Target Neighborhood Hits	888	Shared Neighborhood Hits	834
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

PCTK2_MOUSE
NC score	0.921657 (rank : 330)	θ value	3.17815e-21 (rank : 331)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	822
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK2_HUMAN
NC score	0.921644 (rank : 331)	θ value	2.43343e-21 (rank : 328)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	822
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

PCTK3_HUMAN
NC score	0.921265 (rank : 332)	θ value	1.6852e-22 (rank : 293)
Query Neighborhood Hits	1311	Target Neighborhood Hits	827	Shared Neighborhood Hits	816
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

M3K7_MOUSE
NC score	0.921182 (rank : 333)	θ value	1.5773e-20 (rank : 353)
Query Neighborhood Hits	1311	Target Neighborhood Hits	892	Shared Neighborhood Hits	846
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.920984 (rank : 334)	θ value	1.5773e-20 (rank : 352)
Query Neighborhood Hits	1311	Target Neighborhood Hits	892	Shared Neighborhood Hits	845
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

CD2L7_HUMAN
NC score	0.920912 (rank : 335)	θ value	1.86321e-21 (rank : 322)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1275	Shared Neighborhood Hits	882
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

IRAK4_MOUSE
NC score	0.920784 (rank : 336)	θ value	4.29542e-18 (rank : 430)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	808
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

CD2L5_MOUSE
NC score	0.920762 (rank : 337)	θ value	4.58923e-20 (rank : 367)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1011	Shared Neighborhood Hits	851
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L5_HUMAN
NC score	0.920748 (rank : 338)	θ value	4.58923e-20 (rank : 366)
Query Neighborhood Hits	1311	Target Neighborhood Hits	987	Shared Neighborhood Hits	843
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

KPCE_MOUSE
NC score	0.920542 (rank : 339)	θ value	2.35151e-24 (rank : 225)
Query Neighborhood Hits	1311	Target Neighborhood Hits	906	Shared Neighborhood Hits	825
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KGP1A_HUMAN
NC score	0.920487 (rank : 340)	θ value	9.24701e-21 (rank : 341)
Query Neighborhood Hits	1311	Target Neighborhood Hits	901	Shared Neighborhood Hits	837
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

M4K4_HUMAN
NC score	0.920234 (rank : 341)	θ value	4.14116e-29 (rank : 103)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1589	Shared Neighborhood Hits	996
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

TAOK3_MOUSE
NC score	0.920136 (rank : 342)	θ value	1.12775e-26 (rank : 155)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1458	Shared Neighborhood Hits	1005
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

KPCE_HUMAN
NC score	0.920066 (rank : 343)	θ value	1.37858e-24 (rank : 219)
Query Neighborhood Hits	1311	Target Neighborhood Hits	906	Shared Neighborhood Hits	826
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

KGP1B_MOUSE
NC score	0.919994 (rank : 344)	θ value	9.24701e-21 (rank : 343)
Query Neighborhood Hits	1311	Target Neighborhood Hits	922	Shared Neighborhood Hits	842
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.919898 (rank : 345)	θ value	9.24701e-21 (rank : 342)
Query Neighborhood Hits	1311	Target Neighborhood Hits	921	Shared Neighborhood Hits	842
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

GRK5_MOUSE
NC score	0.919745 (rank : 346)	θ value	1.74391e-19 (rank : 388)
Query Neighborhood Hits	1311	Target Neighborhood Hits	823	Shared Neighborhood Hits	812
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KPCL_MOUSE
NC score	0.919614 (rank : 347)	θ value	1.62847e-25 (rank : 188)
Query Neighborhood Hits	1311	Target Neighborhood Hits	891	Shared Neighborhood Hits	822
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

GRK5_HUMAN
NC score	0.919365 (rank : 348)	θ value	2.97466e-19 (rank : 394)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	812
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

MK15_HUMAN
NC score	0.918997 (rank : 349)	θ value	2.13179e-17 (rank : 451)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1038	Shared Neighborhood Hits	833
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

GRK7_HUMAN
NC score	0.918987 (rank : 350)	θ value	6.20254e-17 (rank : 468)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	815
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

M4K4_MOUSE
NC score	0.918983 (rank : 351)	θ value	2.05525e-28 (rank : 115)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1560	Shared Neighborhood Hits	997
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

KPCD_MOUSE
NC score	0.918916 (rank : 352)	θ value	9.24701e-21 (rank : 345)
Query Neighborhood Hits	1311	Target Neighborhood Hits	888	Shared Neighborhood Hits	828
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

CCRK_HUMAN
NC score	0.918896 (rank : 353)	θ value	3.28887e-18 (rank : 425)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	827
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

CDK10_HUMAN
NC score	0.918805 (rank : 354)	θ value	2.59989e-23 (rank : 263)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	827
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

GRK4_HUMAN
NC score	0.918701 (rank : 355)	θ value	2.69047e-20 (rank : 360)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	813
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

TESK1_MOUSE
NC score	0.918501 (rank : 356)	θ value	6.62687e-19 (rank : 409)
Query Neighborhood Hits	1311	Target Neighborhood Hits	862	Shared Neighborhood Hits	802
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

AL2S7_HUMAN
NC score	0.918163 (rank : 357)	θ value	6.20254e-17 (rank : 467)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	821
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

TAOK3_HUMAN
NC score	0.918054 (rank : 358)	θ value	6.61148e-27 (rank : 150)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1494	Shared Neighborhood Hits	1018
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TLK2_HUMAN
NC score	0.917767 (rank : 359)	θ value	8.65492e-19 (rank : 411)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1044	Shared Neighborhood Hits	868
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

MK12_MOUSE
NC score	0.917540 (rank : 360)	θ value	1.33526e-19 (rank : 385)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	826
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

TESK2_MOUSE
NC score	0.917472 (rank : 361)	θ value	2.13179e-17 (rank : 453)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	814
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TTK_MOUSE
NC score	0.917405 (rank : 362)	θ value	2.43908e-13 (rank : 593)
Query Neighborhood Hits	1311	Target Neighborhood Hits	803	Shared Neighborhood Hits	763
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

TESK1_HUMAN
NC score	0.917217 (rank : 363)	θ value	2.27762e-19 (rank : 393)
Query Neighborhood Hits	1311	Target Neighborhood Hits	864	Shared Neighborhood Hits	803
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_HUMAN
NC score	0.917182 (rank : 364)	θ value	8.10077e-17 (rank : 477)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	817
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

PIM2_HUMAN
NC score	0.917161 (rank : 365)	θ value	2.0648e-12 (rank : 621)
Query Neighborhood Hits	1311	Target Neighborhood Hits	808	Shared Neighborhood Hits	805
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

CDK9_HUMAN
NC score	0.917153 (rank : 366)	θ value	8.36355e-22 (rank : 309)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	817
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CI096_HUMAN
NC score	0.916974 (rank : 367)	θ value	6.41864e-14 (rank : 582)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	802
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

MAST3_HUMAN
NC score	0.916973 (rank : 368)	θ value	3.17815e-21 (rank : 330)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1128	Shared Neighborhood Hits	850
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

CDK9_MOUSE
NC score	0.916683 (rank : 369)	θ value	6.40375e-22 (rank : 305)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	817
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

TLK2_MOUSE
NC score	0.916518 (rank : 370)	θ value	8.65492e-19 (rank : 412)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1088	Shared Neighborhood Hits	888
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

MK12_HUMAN
NC score	0.916402 (rank : 371)	θ value	7.32683e-18 (rank : 437)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	825
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

PIM2_MOUSE
NC score	0.916250 (rank : 372)	θ value	1.86753e-13 (rank : 590)
Query Neighborhood Hits	1311	Target Neighborhood Hits	809	Shared Neighborhood Hits	799
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

KPCZ_MOUSE
NC score	0.916198 (rank : 373)	θ value	1.6852e-22 (rank : 292)
Query Neighborhood Hits	1311	Target Neighborhood Hits	882	Shared Neighborhood Hits	831
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCL_HUMAN
NC score	0.916192 (rank : 374)	θ value	1.05554e-24 (rank : 215)
Query Neighborhood Hits	1311	Target Neighborhood Hits	887	Shared Neighborhood Hits	821
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MK14_MOUSE
NC score	0.916174 (rank : 375)	θ value	1.42661e-21 (rank : 320)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	831
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

IRAK4_HUMAN
NC score	0.916164 (rank : 376)	θ value	5.25075e-16 (rank : 512)
Query Neighborhood Hits	1311	Target Neighborhood Hits	816	Shared Neighborhood Hits	807
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

KPCZ_HUMAN
NC score	0.916161 (rank : 377)	θ value	1.6852e-22 (rank : 291)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	830
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

CCRK_MOUSE
NC score	0.916108 (rank : 378)	θ value	1.38178e-16 (rank : 479)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	824
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

GRK4_MOUSE
NC score	0.916066 (rank : 379)	θ value	7.0802e-21 (rank : 339)
Query Neighborhood Hits	1311	Target Neighborhood Hits	808	Shared Neighborhood Hits	805
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

MK14_HUMAN
NC score	0.916007 (rank : 380)	θ value	2.43343e-21 (rank : 325)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	831
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

MKNK2_HUMAN
NC score	0.915947 (rank : 381)	θ value	1.68911e-14 (rank : 567)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	813
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

MAST2_MOUSE
NC score	0.915946 (rank : 382)	θ value	2.59989e-23 (rank : 265)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1110	Shared Neighborhood Hits	866
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

TLK1_HUMAN
NC score	0.915314 (rank : 383)	θ value	4.74913e-17 (rank : 465)
Query Neighborhood Hits	1311	Target Neighborhood Hits	967	Shared Neighborhood Hits	829
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

E2AK1_MOUSE
NC score	0.915257 (rank : 384)	θ value	2.36244e-08 (rank : 747)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	813
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

TLK1_MOUSE
NC score	0.915072 (rank : 385)	θ value	4.74913e-17 (rank : 466)
Query Neighborhood Hits	1311	Target Neighborhood Hits	947	Shared Neighborhood Hits	829
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

STK10_HUMAN
NC score	0.914881 (rank : 386)	θ value	8.06329e-33 (rank : 40)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1921	Shared Neighborhood Hits	1079
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CDK4_MOUSE
NC score	0.914852 (rank : 387)	θ value	8.95645e-16 (rank : 521)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	830
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

E2AK4_HUMAN
NC score	0.914627 (rank : 388)	θ value	1.68911e-14 (rank : 566)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1012	Shared Neighborhood Hits	869
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

MAST2_HUMAN
NC score	0.914498 (rank : 389)	θ value	7.56453e-23 (rank : 276)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1189	Shared Neighborhood Hits	873
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MK15_MOUSE
NC score	0.914269 (rank : 390)	θ value	4.02038e-16 (rank : 505)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	816
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

MKNK2_MOUSE
NC score	0.914123 (rank : 391)	θ value	1.68911e-14 (rank : 568)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	812
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

CDK4_HUMAN
NC score	0.913822 (rank : 392)	θ value	2.35696e-16 (rank : 491)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	828
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

NLK_MOUSE
NC score	0.913627 (rank : 393)	θ value	3.07829e-16 (rank : 500)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	829
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NLK_HUMAN
NC score	0.913610 (rank : 394)	θ value	3.07829e-16 (rank : 499)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	829
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

E2AK1_HUMAN
NC score	0.913415 (rank : 395)	θ value	1.06045e-08 (rank : 743)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	819
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

WNK1_HUMAN
NC score	0.912947 (rank : 396)	θ value	6.40375e-22 (rank : 307)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1158	Shared Neighborhood Hits	800
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

RAF1_HUMAN
NC score	0.912850 (rank : 397)	θ value	1.37858e-24 (rank : 220)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	837
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

MK07_MOUSE
NC score	0.912742 (rank : 398)	θ value	1.63225e-17 (rank : 447)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1054	Shared Neighborhood Hits	840
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

RAF1_MOUSE
NC score	0.912632 (rank : 399)	θ value	2.59989e-23 (rank : 266)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	838
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

BRAF1_HUMAN
NC score	0.912583 (rank : 400)	θ value	3.07116e-24 (rank : 230)
Query Neighborhood Hits	1311	Target Neighborhood Hits	883	Shared Neighborhood Hits	828
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

MK13_MOUSE
NC score	0.912483 (rank : 401)	θ value	2.7842e-17 (rank : 458)
Query Neighborhood Hits	1311	Target Neighborhood Hits	832	Shared Neighborhood Hits	826
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK07_HUMAN
NC score	0.912418 (rank : 402)	θ value	1.63225e-17 (rank : 446)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1087	Shared Neighborhood Hits	850
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

RIPK1_HUMAN
NC score	0.912012 (rank : 403)	θ value	2.60593e-15 (rank : 540)
Query Neighborhood Hits	1311	Target Neighborhood Hits	891	Shared Neighborhood Hits	841
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

MK13_HUMAN
NC score	0.911792 (rank : 404)	θ value	5.60996e-18 (rank : 434)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	827
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK03_HUMAN
NC score	0.911734 (rank : 405)	θ value	1.5773e-20 (rank : 354)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	829
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

WNK4_MOUSE
NC score	0.911662 (rank : 406)	θ value	3.17815e-21 (rank : 333)
Query Neighborhood Hits	1311	Target Neighborhood Hits	961	Shared Neighborhood Hits	768
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ARBK1_HUMAN
NC score	0.911393 (rank : 407)	θ value	1.63225e-17 (rank : 443)
Query Neighborhood Hits	1311	Target Neighborhood Hits	859	Shared Neighborhood Hits	817
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

WNK1_MOUSE
NC score	0.911361 (rank : 408)	θ value	6.40375e-22 (rank : 308)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1179	Shared Neighborhood Hits	809
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

MAST1_HUMAN
NC score	0.910994 (rank : 409)	θ value	2.06002e-20 (rank : 357)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1146	Shared Neighborhood Hits	860
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MK03_MOUSE
NC score	0.910926 (rank : 410)	θ value	1.5773e-20 (rank : 355)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	829
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

RIPK5_HUMAN
NC score	0.910889 (rank : 411)	θ value	2.52405e-10 (rank : 684)
Query Neighborhood Hits	1311	Target Neighborhood Hits	864	Shared Neighborhood Hits	841
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

MAST1_MOUSE
NC score	0.910826 (rank : 412)	θ value	7.0802e-21 (rank : 340)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1123	Shared Neighborhood Hits	848
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

MKNK1_MOUSE
NC score	0.910799 (rank : 413)	θ value	1.52774e-15 (rank : 529)
Query Neighborhood Hits	1311	Target Neighborhood Hits	811	Shared Neighborhood Hits	800
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

RIPK5_MOUSE
NC score	0.910472 (rank : 414)	θ value	2.52405e-10 (rank : 685)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	843
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

MOK_HUMAN
NC score	0.909835 (rank : 415)	θ value	3.07116e-24 (rank : 231)
Query Neighborhood Hits	1311	Target Neighborhood Hits	807	Shared Neighborhood Hits	799
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

ARBK1_MOUSE
NC score	0.909825 (rank : 416)	θ value	3.28887e-18 (rank : 424)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	817
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

E2AK4_MOUSE
NC score	0.909801 (rank : 417)	θ value	4.91457e-14 (rank : 580)
Query Neighborhood Hits	1311	Target Neighborhood Hits	984	Shared Neighborhood Hits	864
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

GSK3A_HUMAN
NC score	0.909301 (rank : 418)	θ value	2.28291e-11 (rank : 648)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	799
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

ARBK2_HUMAN
NC score	0.909164 (rank : 419)	θ value	1.63225e-17 (rank : 444)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	817
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

PIM1_HUMAN
NC score	0.908656 (rank : 420)	θ value	9.26847e-13 (rank : 610)
Query Neighborhood Hits	1311	Target Neighborhood Hits	797	Shared Neighborhood Hits	792
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

MK11_MOUSE
NC score	0.908492 (rank : 421)	θ value	1.29331e-14 (rank : 562)
Query Neighborhood Hits	1311	Target Neighborhood Hits	835	Shared Neighborhood Hits	829
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MOK_MOUSE
NC score	0.908371 (rank : 422)	θ value	1.99067e-23 (rank : 258)
Query Neighborhood Hits	1311	Target Neighborhood Hits	796	Shared Neighborhood Hits	793
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

WNK4_HUMAN
NC score	0.908087 (rank : 423)	θ value	1.2077e-20 (rank : 350)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1043	Shared Neighborhood Hits	775
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

CD2L2_HUMAN
NC score	0.907958 (rank : 424)	θ value	1.37858e-24 (rank : 218)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1439	Shared Neighborhood Hits	975
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

MK04_HUMAN
NC score	0.907706 (rank : 425)	θ value	1.058e-16 (rank : 478)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	817
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MK01_MOUSE
NC score	0.907351 (rank : 426)	θ value	7.82807e-20 (rank : 376)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	828
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_HUMAN
NC score	0.907279 (rank : 427)	θ value	1.02238e-19 (rank : 381)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	828
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

F5006_MOUSE
NC score	0.907273 (rank : 428)	θ value	1.33837e-11 (rank : 639)
Query Neighborhood Hits	1311	Target Neighborhood Hits	793	Shared Neighborhood Hits	790
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

PIM1_MOUSE
NC score	0.907069 (rank : 429)	θ value	1.86753e-13 (rank : 589)
Query Neighborhood Hits	1311	Target Neighborhood Hits	787	Shared Neighborhood Hits	780
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

TAOK1_MOUSE
NC score	0.906734 (rank : 430)	θ value	3.87602e-27 (rank : 144)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1720	Shared Neighborhood Hits	1062
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

MLTK_MOUSE
NC score	0.906666 (rank : 431)	θ value	1.02238e-19 (rank : 382)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	828
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

GSK3B_HUMAN
NC score	0.906615 (rank : 432)	θ value	7.09661e-13 (rank : 602)
Query Neighborhood Hits	1311	Target Neighborhood Hits	801	Shared Neighborhood Hits	797
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.906594 (rank : 433)	θ value	7.09661e-13 (rank : 603)
Query Neighborhood Hits	1311	Target Neighborhood Hits	800	Shared Neighborhood Hits	796
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

PIM3_HUMAN
NC score	0.906516 (rank : 434)	θ value	1.9326e-10 (rank : 680)
Query Neighborhood Hits	1311	Target Neighborhood Hits	789	Shared Neighborhood Hits	786
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

RIPK1_MOUSE
NC score	0.906510 (rank : 435)	θ value	3.40345e-15 (rank : 546)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	839
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

TAOK1_HUMAN
NC score	0.906325 (rank : 436)	θ value	5.06226e-27 (rank : 146)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1734	Shared Neighborhood Hits	1060
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

ARAF_HUMAN
NC score	0.906286 (rank : 437)	θ value	4.15078e-21 (rank : 334)
Query Neighborhood Hits	1311	Target Neighborhood Hits	924	Shared Neighborhood Hits	835
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

MLTK_HUMAN
NC score	0.906284 (rank : 438)	θ value	3.51386e-20 (rank : 365)
Query Neighborhood Hits	1311	Target Neighborhood Hits	911	Shared Neighborhood Hits	829
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

ARAF_MOUSE
NC score	0.905922 (rank : 439)	θ value	2.69047e-20 (rank : 359)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	832
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

BMP2K_HUMAN
NC score	0.905554 (rank : 440)	θ value	1.29031e-22 (rank : 288)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	791
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

MK04_MOUSE
NC score	0.905540 (rank : 441)	θ value	8.10077e-17 (rank : 475)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	810
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

CD2L1_HUMAN
NC score	0.905069 (rank : 442)	θ value	2.35151e-24 (rank : 224)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1467	Shared Neighborhood Hits	980
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

MK09_HUMAN
NC score	0.904880 (rank : 443)	θ value	3.63628e-17 (rank : 461)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	831
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MK11_HUMAN
NC score	0.904371 (rank : 444)	θ value	2.35696e-16 (rank : 492)
Query Neighborhood Hits	1311	Target Neighborhood Hits	823	Shared Neighborhood Hits	822
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

CD2L1_MOUSE
NC score	0.904236 (rank : 445)	θ value	1.16704e-23 (rank : 244)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1463	Shared Neighborhood Hits	980
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

BMP2K_MOUSE
NC score	0.903807 (rank : 446)	θ value	1.29031e-22 (rank : 289)
Query Neighborhood Hits	1311	Target Neighborhood Hits	874	Shared Neighborhood Hits	790
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

M3K10_HUMAN
NC score	0.903687 (rank : 447)	θ value	6.20254e-17 (rank : 469)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1071	Shared Neighborhood Hits	848
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

KPCA_MOUSE
NC score	0.903633 (rank : 448)	θ value	1.5242e-23 (rank : 251)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1067	Shared Neighborhood Hits	824
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

ERN1_HUMAN
NC score	0.903354 (rank : 449)	θ value	3.29651e-10 (rank : 688)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	814
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

M3K9_HUMAN
NC score	0.903203 (rank : 450)	θ value	1.13037e-18 (rank : 414)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1123	Shared Neighborhood Hits	863
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

PIM3_MOUSE
NC score	0.903010 (rank : 451)	θ value	8.67504e-11 (rank : 672)
Query Neighborhood Hits	1311	Target Neighborhood Hits	783	Shared Neighborhood Hits	780
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

CAMKV_MOUSE
NC score	0.901833 (rank : 452)	θ value	7.32683e-18 (rank : 436)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	779
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MK09_MOUSE
NC score	0.901707 (rank : 453)	θ value	2.7842e-17 (rank : 457)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	829
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK08_MOUSE
NC score	0.901635 (rank : 454)	θ value	6.20254e-17 (rank : 471)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	826
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

KPCA_HUMAN
NC score	0.901588 (rank : 455)	θ value	1.5242e-23 (rank : 250)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1070	Shared Neighborhood Hits	828
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MOS_MOUSE
NC score	0.901406 (rank : 456)	θ value	1.80886e-08 (rank : 745)
Query Neighborhood Hits	1311	Target Neighborhood Hits	833	Shared Neighborhood Hits	825
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MAST4_HUMAN
NC score	0.901167 (rank : 457)	θ value	1.42661e-21 (rank : 319)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1804	Shared Neighborhood Hits	907
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ERN1_MOUSE
NC score	0.901025 (rank : 458)	θ value	1.63604e-09 (rank : 714)
Query Neighborhood Hits	1311	Target Neighborhood Hits	823	Shared Neighborhood Hits	811
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK10_HUMAN
NC score	0.900977 (rank : 459)	θ value	3.63628e-17 (rank : 462)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	825
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK08_HUMAN
NC score	0.900961 (rank : 460)	θ value	6.20254e-17 (rank : 470)
Query Neighborhood Hits	1311	Target Neighborhood Hits	834	Shared Neighborhood Hits	826
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MOS_HUMAN
NC score	0.900881 (rank : 461)	θ value	2.13673e-09 (rank : 720)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	827
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

M3K11_HUMAN
NC score	0.900783 (rank : 462)	θ value	8.65492e-19 (rank : 410)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1136	Shared Neighborhood Hits	849
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MK10_MOUSE
NC score	0.900742 (rank : 463)	θ value	3.63628e-17 (rank : 463)
Query Neighborhood Hits	1311	Target Neighborhood Hits	849	Shared Neighborhood Hits	825
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

STK38_MOUSE
NC score	0.899815 (rank : 464)	θ value	1.2077e-20 (rank : 349)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	818
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

STK38_HUMAN
NC score	0.899492 (rank : 465)	θ value	1.2077e-20 (rank : 348)
Query Neighborhood Hits	1311	Target Neighborhood Hits	840	Shared Neighborhood Hits	818
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

WNK2_HUMAN
NC score	0.899084 (rank : 466)	θ value	2.06002e-20 (rank : 358)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1407	Shared Neighborhood Hits	800
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ST38L_HUMAN
NC score	0.898894 (rank : 467)	θ value	4.58923e-20 (rank : 369)
Query Neighborhood Hits	1311	Target Neighborhood Hits	824	Shared Neighborhood Hits	809
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

AAK1_MOUSE
NC score	0.898722 (rank : 468)	θ value	2.59989e-23 (rank : 262)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1051	Shared Neighborhood Hits	801
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

GAK_HUMAN
NC score	0.898137 (rank : 469)	θ value	8.63488e-27 (rank : 151)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1028	Shared Neighborhood Hits	822
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

DMPK_MOUSE
NC score	0.897568 (rank : 470)	θ value	6.62687e-19 (rank : 407)
Query Neighborhood Hits	1311	Target Neighborhood Hits	908	Shared Neighborhood Hits	838
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

F5006_HUMAN
NC score	0.897314 (rank : 471)	θ value	2.98157e-11 (rank : 654)
Query Neighborhood Hits	1311	Target Neighborhood Hits	794	Shared Neighborhood Hits	784
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

DMPK_HUMAN
NC score	0.897091 (rank : 472)	θ value	1.02238e-19 (rank : 380)
Query Neighborhood Hits	1311	Target Neighborhood Hits	944	Shared Neighborhood Hits	847
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

CD2L6_MOUSE
NC score	0.896824 (rank : 473)	θ value	1.99529e-15 (rank : 533)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	819
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L6_HUMAN
NC score	0.896782 (rank : 474)	θ value	1.99529e-15 (rank : 532)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	816
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

AAK1_HUMAN
NC score	0.896651 (rank : 475)	θ value	2.59989e-23 (rank : 261)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1077	Shared Neighborhood Hits	802
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

MAPK5_MOUSE
NC score	0.896333 (rank : 476)	θ value	1.13037e-18 (rank : 417)
Query Neighborhood Hits	1311	Target Neighborhood Hits	799	Shared Neighborhood Hits	789
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

MK06_HUMAN
NC score	0.896059 (rank : 477)	θ value	2.7842e-17 (rank : 456)
Query Neighborhood Hits	1311	Target Neighborhood Hits	815	Shared Neighborhood Hits	799
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

CAMKV_HUMAN
NC score	0.895732 (rank : 478)	θ value	7.32683e-18 (rank : 435)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1084	Shared Neighborhood Hits	806
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

MK06_MOUSE
NC score	0.895553 (rank : 479)	θ value	2.13179e-17 (rank : 450)
Query Neighborhood Hits	1311	Target Neighborhood Hits	818	Shared Neighborhood Hits	800
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

ERN2_HUMAN
NC score	0.894989 (rank : 480)	θ value	3.29651e-10 (rank : 689)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MAPK5_HUMAN
NC score	0.894124 (rank : 481)	θ value	1.13037e-18 (rank : 416)
Query Neighborhood Hits	1311	Target Neighborhood Hits	795	Shared Neighborhood Hits	785
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

STK10_MOUSE
NC score	0.893945 (rank : 482)	θ value	2.34606e-32 (rank : 42)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2132	Shared Neighborhood Hits	1114
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

KPCB_MOUSE
NC score	0.893794 (rank : 483)	θ value	1.42661e-21 (rank : 318)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1117	Shared Neighborhood Hits	828
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_HUMAN
NC score	0.893364 (rank : 484)	θ value	1.42661e-21 (rank : 317)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1121	Shared Neighborhood Hits	829
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

GAK_MOUSE
NC score	0.893212 (rank : 485)	θ value	1.47289e-26 (rank : 156)
Query Neighborhood Hits	1311	Target Neighborhood Hits	964	Shared Neighborhood Hits	815
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

WEE1_MOUSE
NC score	0.892828 (rank : 486)	θ value	4.02038e-16 (rank : 509)
Query Neighborhood Hits	1311	Target Neighborhood Hits	794	Shared Neighborhood Hits	758
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

CDK8_HUMAN
NC score	0.892722 (rank : 487)	θ value	1.52774e-15 (rank : 528)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	817
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

M3KL4_HUMAN
NC score	0.891031 (rank : 488)	θ value	1.13037e-18 (rank : 415)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1087	Shared Neighborhood Hits	856
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

KPCG_MOUSE
NC score	0.890874 (rank : 489)	θ value	2.06002e-20 (rank : 356)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1123	Shared Neighborhood Hits	826
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCG_HUMAN
NC score	0.890379 (rank : 490)	θ value	2.69047e-20 (rank : 362)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1126	Shared Neighborhood Hits	827
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

CSKP_MOUSE
NC score	0.890271 (rank : 491)	θ value	7.80994e-28 (rank : 131)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1027	Shared Neighborhood Hits	814
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

ST38L_MOUSE
NC score	0.890269 (rank : 492)	θ value	2.97466e-19 (rank : 398)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	804
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

ERN2_MOUSE
NC score	0.890109 (rank : 493)	θ value	1.53129e-07 (rank : 758)
Query Neighborhood Hits	1311	Target Neighborhood Hits	825	Shared Neighborhood Hits	810
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

LIMK2_HUMAN
NC score	0.889392 (rank : 494)	θ value	2.13179e-17 (rank : 449)
Query Neighborhood Hits	1311	Target Neighborhood Hits	986	Shared Neighborhood Hits	818
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

CSKP_HUMAN
NC score	0.887625 (rank : 495)	θ value	7.80994e-28 (rank : 130)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1022	Shared Neighborhood Hits	814
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

LIMK2_MOUSE
NC score	0.885858 (rank : 496)	θ value	4.74913e-17 (rank : 464)
Query Neighborhood Hits	1311	Target Neighborhood Hits	998	Shared Neighborhood Hits	817
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

KSR2_HUMAN
NC score	0.884950 (rank : 497)	θ value	6.00763e-12 (rank : 628)
Query Neighborhood Hits	1311	Target Neighborhood Hits	920	Shared Neighborhood Hits	811
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

LIMK1_HUMAN
NC score	0.884420 (rank : 498)	θ value	1.13037e-18 (rank : 413)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1005	Shared Neighborhood Hits	824
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LATS1_HUMAN
NC score	0.884055 (rank : 499)	θ value	2.13179e-17 (rank : 448)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1057	Shared Neighborhood Hits	869
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

LIMK1_MOUSE
NC score	0.884048 (rank : 500)	θ value	2.97466e-19 (rank : 396)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1008	Shared Neighborhood Hits	822
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

HIPK4_HUMAN
NC score	0.883037 (rank : 501)	θ value	6.64225e-11 (rank : 668)
Query Neighborhood Hits	1311	Target Neighborhood Hits	799	Shared Neighborhood Hits	787
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

RIPK3_HUMAN
NC score	0.882880 (rank : 502)	θ value	2.88788e-06 (rank : 776)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	807
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

LATS1_MOUSE
NC score	0.881120 (rank : 503)	θ value	8.10077e-17 (rank : 474)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1027	Shared Neighborhood Hits	862
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

WEE1_HUMAN
NC score	0.881083 (rank : 504)	θ value	2.35696e-16 (rank : 494)
Query Neighborhood Hits	1311	Target Neighborhood Hits	777	Shared Neighborhood Hits	735
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

RIPK3_MOUSE
NC score	0.880148 (rank : 505)	θ value	4.92598e-06 (rank : 779)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	808
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

LATS2_HUMAN
NC score	0.879547 (rank : 506)	θ value	3.88503e-19 (rank : 402)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	826
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
NC score	0.879394 (rank : 507)	θ value	3.88503e-19 (rank : 403)
Query Neighborhood Hits	1311	Target Neighborhood Hits	879	Shared Neighborhood Hits	829
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

JAK2_HUMAN
NC score	0.876676 (rank : 508)	θ value	2.97466e-19 (rank : 395)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	830
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

CSK21_MOUSE
NC score	0.876067 (rank : 509)	θ value	3.08544e-08 (rank : 751)
Query Neighborhood Hits	1311	Target Neighborhood Hits	770	Shared Neighborhood Hits	766
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

JAK2_MOUSE
NC score	0.875772 (rank : 510)	θ value	3.88503e-19 (rank : 401)
Query Neighborhood Hits	1311	Target Neighborhood Hits	839	Shared Neighborhood Hits	825
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

CSK21_HUMAN
NC score	0.875307 (rank : 511)	θ value	3.08544e-08 (rank : 750)
Query Neighborhood Hits	1311	Target Neighborhood Hits	772	Shared Neighborhood Hits	766
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

MRCKG_HUMAN
NC score	0.875175 (rank : 512)	θ value	9.24701e-21 (rank : 346)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1519	Shared Neighborhood Hits	973
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
NC score	0.874276 (rank : 513)	θ value	1.92812e-18 (rank : 422)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1466	Shared Neighborhood Hits	971
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

JAK3_MOUSE
NC score	0.872224 (rank : 514)	θ value	6.85773e-16 (rank : 516)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	812
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

MYLK_HUMAN
NC score	0.869296 (rank : 515)	θ value	4.01107e-24 (rank : 237)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1328	Shared Neighborhood Hits	853
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

CSK22_MOUSE
NC score	0.868863 (rank : 516)	θ value	4.76016e-09 (rank : 735)
Query Neighborhood Hits	1311	Target Neighborhood Hits	758	Shared Neighborhood Hits	758
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

DYRK3_HUMAN
NC score	0.868823 (rank : 517)	θ value	2.28291e-11 (rank : 646)
Query Neighborhood Hits	1311	Target Neighborhood Hits	798	Shared Neighborhood Hits	788
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

STK40_HUMAN
NC score	0.868715 (rank : 518)	θ value	1.47974e-10 (rank : 674)
Query Neighborhood Hits	1311	Target Neighborhood Hits	751	Shared Neighborhood Hits	743
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

TYK2_HUMAN
NC score	0.868604 (rank : 519)	θ value	2.7842e-17 (rank : 459)
Query Neighborhood Hits	1311	Target Neighborhood Hits	841	Shared Neighborhood Hits	828
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

STK40_MOUSE
NC score	0.868405 (rank : 520)	θ value	1.47974e-10 (rank : 675)
Query Neighborhood Hits	1311	Target Neighborhood Hits	751	Shared Neighborhood Hits	743
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

CSK22_HUMAN
NC score	0.868326 (rank : 521)	θ value	1.06045e-08 (rank : 742)
Query Neighborhood Hits	1311	Target Neighborhood Hits	758	Shared Neighborhood Hits	758
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

JAK3_HUMAN
NC score	0.867637 (rank : 522)	θ value	3.07829e-16 (rank : 497)
Query Neighborhood Hits	1311	Target Neighborhood Hits	827	Shared Neighborhood Hits	819
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

MYLK_MOUSE
NC score	0.867621 (rank : 523)	θ value	8.08199e-25 (rank : 210)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1489	Shared Neighborhood Hits	867
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

WEE1B_HUMAN
NC score	0.866666 (rank : 524)	θ value	4.29542e-18 (rank : 432)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	745
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

DYRK2_HUMAN
NC score	0.866472 (rank : 525)	θ value	1.74796e-11 (rank : 644)
Query Neighborhood Hits	1311	Target Neighborhood Hits	799	Shared Neighborhood Hits	787
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

WEE1B_MOUSE
NC score	0.863787 (rank : 526)	θ value	2.97466e-19 (rank : 399)
Query Neighborhood Hits	1311	Target Neighborhood Hits	765	Shared Neighborhood Hits	733
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

TYK2_MOUSE
NC score	0.863557 (rank : 527)	θ value	6.20254e-17 (rank : 472)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	826
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

JAK1_HUMAN
NC score	0.859140 (rank : 528)	θ value	6.62687e-19 (rank : 408)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	831
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

AL2S2_HUMAN
NC score	0.857350 (rank : 529)	θ value	9.59137e-10 (rank : 697)
Query Neighborhood Hits	1311	Target Neighborhood Hits	727	Shared Neighborhood Hits	715
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

DYR1B_MOUSE
NC score	0.855567 (rank : 530)	θ value	1.63604e-09 (rank : 713)
Query Neighborhood Hits	1311	Target Neighborhood Hits	799	Shared Neighborhood Hits	764
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

KSR1_MOUSE
NC score	0.854622 (rank : 531)	θ value	2.36244e-08 (rank : 748)
Query Neighborhood Hits	1311	Target Neighborhood Hits	870	Shared Neighborhood Hits	807
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

JAK1_MOUSE
NC score	0.853732 (rank : 532)	θ value	1.63225e-17 (rank : 445)
Query Neighborhood Hits	1311	Target Neighborhood Hits	854	Shared Neighborhood Hits	828
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

RIPK2_MOUSE
NC score	0.853463 (rank : 533)	θ value	1.63604e-09 (rank : 717)
Query Neighborhood Hits	1311	Target Neighborhood Hits	776	Shared Neighborhood Hits	755
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

DYR1B_HUMAN
NC score	0.853021 (rank : 534)	θ value	3.64472e-09 (rank : 729)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	765
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

HIPK3_MOUSE
NC score	0.851773 (rank : 535)	θ value	1.33837e-11 (rank : 641)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	792
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

FES_MOUSE
NC score	0.851703 (rank : 536)	θ value	6.41864e-14 (rank : 583)
Query Neighborhood Hits	1311	Target Neighborhood Hits	980	Shared Neighborhood Hits	840
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

DAPK1_HUMAN
NC score	0.851661 (rank : 537)	θ value	5.99374e-20 (rank : 372)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1130	Shared Neighborhood Hits	835
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

FES_HUMAN
NC score	0.851136 (rank : 538)	θ value	8.38298e-14 (rank : 585)
Query Neighborhood Hits	1311	Target Neighborhood Hits	978	Shared Neighborhood Hits	827
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

SPEG_HUMAN
NC score	0.850801 (rank : 539)	θ value	1.80466e-16 (rank : 490)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1762	Shared Neighborhood Hits	875
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

RIPK2_HUMAN
NC score	0.850723 (rank : 540)	θ value	2.79066e-09 (rank : 726)
Query Neighborhood Hits	1311	Target Neighborhood Hits	774	Shared Neighborhood Hits	756
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

HIPK3_HUMAN
NC score	0.849973 (rank : 541)	θ value	1.33837e-11 (rank : 640)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	801
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

PTK6_HUMAN
NC score	0.849754 (rank : 542)	θ value	1.16975e-15 (rank : 525)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1020	Shared Neighborhood Hits	827
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

DAPK1_MOUSE
NC score	0.847588 (rank : 543)	θ value	1.02238e-19 (rank : 379)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1138	Shared Neighborhood Hits	835
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

PTK6_MOUSE
NC score	0.846800 (rank : 544)	θ value	8.10077e-17 (rank : 476)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1026	Shared Neighborhood Hits	828
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

HIPK1_HUMAN
NC score	0.846089 (rank : 545)	θ value	1.25267e-09 (rank : 704)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	786
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.846028 (rank : 546)	θ value	1.25267e-09 (rank : 705)
Query Neighborhood Hits	1311	Target Neighborhood Hits	838	Shared Neighborhood Hits	787
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

UHMK1_HUMAN
NC score	0.845764 (rank : 547)	θ value	0.0961366 (rank : 885)
Query Neighborhood Hits	1311	Target Neighborhood Hits	808	Shared Neighborhood Hits	774
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

UHMK1_MOUSE
NC score	0.844271 (rank : 548)	θ value	0.125558 (rank : 899)
Query Neighborhood Hits	1311	Target Neighborhood Hits	809	Shared Neighborhood Hits	774
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

TRIO_HUMAN
NC score	0.844250 (rank : 549)	θ value	1.16975e-15 (rank : 527)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1580	Shared Neighborhood Hits	928
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

KSR1_HUMAN
NC score	0.844243 (rank : 550)	θ value	4.45536e-07 (rank : 765)
Query Neighborhood Hits	1311	Target Neighborhood Hits	867	Shared Neighborhood Hits	792
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

SPEG_MOUSE
NC score	0.844151 (rank : 551)	θ value	4.02038e-16 (rank : 508)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1959	Shared Neighborhood Hits	901
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

DYR1A_MOUSE
NC score	0.843683 (rank : 552)	θ value	9.59137e-10 (rank : 700)
Query Neighborhood Hits	1311	Target Neighborhood Hits	762	Shared Neighborhood Hits	752
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1A_HUMAN
NC score	0.843613 (rank : 553)	θ value	9.59137e-10 (rank : 699)
Query Neighborhood Hits	1311	Target Neighborhood Hits	764	Shared Neighborhood Hits	752
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

MKNK1_HUMAN
NC score	0.843485 (rank : 554)	θ value	5.08577e-11 (rank : 665)
Query Neighborhood Hits	1311	Target Neighborhood Hits	701	Shared Neighborhood Hits	691
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

HIPK2_HUMAN
NC score	0.843279 (rank : 555)	θ value	2.52405e-10 (rank : 682)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	783
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
NC score	0.843036 (rank : 556)	θ value	2.52405e-10 (rank : 683)
Query Neighborhood Hits	1311	Target Neighborhood Hits	871	Shared Neighborhood Hits	787
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

PRP4B_HUMAN
NC score	0.842777 (rank : 557)	θ value	2.79066e-09 (rank : 724)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1030	Shared Neighborhood Hits	824
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

AL2S2_MOUSE
NC score	0.842017 (rank : 558)	θ value	2.79066e-09 (rank : 722)
Query Neighborhood Hits	1311	Target Neighborhood Hits	709	Shared Neighborhood Hits	697
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

PRP4B_MOUSE
NC score	0.841048 (rank : 559)	θ value	2.79066e-09 (rank : 725)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1040	Shared Neighborhood Hits	821
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

CSK_MOUSE
NC score	0.840977 (rank : 560)	θ value	3.88503e-19 (rank : 400)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	832
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

IRAK1_HUMAN
NC score	0.840663 (rank : 561)	θ value	2.0648e-12 (rank : 619)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	760
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

DUET_HUMAN
NC score	0.839289 (rank : 562)	θ value	3.89403e-11 (rank : 660)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1220	Shared Neighborhood Hits	814
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

FAK1_HUMAN
NC score	0.839248 (rank : 563)	θ value	1.24977e-17 (rank : 441)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

DYRK4_HUMAN
NC score	0.838965 (rank : 564)	θ value	8.67504e-11 (rank : 670)
Query Neighborhood Hits	1311	Target Neighborhood Hits	750	Shared Neighborhood Hits	743
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

FAK1_MOUSE
NC score	0.838884 (rank : 565)	θ value	1.24977e-17 (rank : 442)
Query Neighborhood Hits	1311	Target Neighborhood Hits	850	Shared Neighborhood Hits	820
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

IRAK1_MOUSE
NC score	0.838702 (rank : 566)	θ value	1.02475e-11 (rank : 636)
Query Neighborhood Hits	1311	Target Neighborhood Hits	784	Shared Neighborhood Hits	747
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

TEC_MOUSE
NC score	0.838221 (rank : 567)	θ value	2.13179e-17 (rank : 452)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1006	Shared Neighborhood Hits	825
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MYO3A_MOUSE
NC score	0.836989 (rank : 568)	θ value	3.07116e-24 (rank : 233)
Query Neighborhood Hits	1311	Target Neighborhood Hits	902	Shared Neighborhood Hits	841
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

FER_HUMAN
NC score	0.836748 (rank : 569)	θ value	4.91457e-14 (rank : 581)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1278	Shared Neighborhood Hits	922
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CSK_HUMAN
NC score	0.834785 (rank : 570)	θ value	4.58923e-20 (rank : 368)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	831
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

BMX_HUMAN
NC score	0.832814 (rank : 571)	θ value	9.56915e-18 (rank : 439)
Query Neighborhood Hits	1311	Target Neighborhood Hits	942	Shared Neighborhood Hits	806
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

ROCK2_HUMAN
NC score	0.832784 (rank : 572)	θ value	6.40375e-22 (rank : 306)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2073	Shared Neighborhood Hits	1069
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

TEC_HUMAN
NC score	0.832683 (rank : 573)	θ value	1.38178e-16 (rank : 481)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1006	Shared Neighborhood Hits	823
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

MATK_MOUSE
NC score	0.832640 (rank : 574)	θ value	2.27762e-19 (rank : 391)
Query Neighborhood Hits	1311	Target Neighborhood Hits	952	Shared Neighborhood Hits	823
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

TXK_HUMAN
NC score	0.832629 (rank : 575)	θ value	1.38178e-16 (rank : 482)
Query Neighborhood Hits	1311	Target Neighborhood Hits	971	Shared Neighborhood Hits	815
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

BMX_MOUSE
NC score	0.831466 (rank : 576)	θ value	5.25075e-16 (rank : 510)
Query Neighborhood Hits	1311	Target Neighborhood Hits	912	Shared Neighborhood Hits	795
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

ZAP70_HUMAN
NC score	0.831022 (rank : 577)	θ value	9.59137e-10 (rank : 702)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	812
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

KSYK_HUMAN
NC score	0.830952 (rank : 578)	θ value	1.63604e-09 (rank : 715)
Query Neighborhood Hits	1311	Target Neighborhood Hits	901	Shared Neighborhood Hits	811
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
NC score	0.830812 (rank : 579)	θ value	1.63604e-09 (rank : 716)
Query Neighborhood Hits	1311	Target Neighborhood Hits	944	Shared Neighborhood Hits	812
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

OBSCN_HUMAN
NC score	0.830734 (rank : 580)	θ value	9.87957e-23 (rank : 281)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1931	Shared Neighborhood Hits	882
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

MYO3A_HUMAN
NC score	0.830442 (rank : 581)	θ value	3.07116e-24 (rank : 232)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1033	Shared Neighborhood Hits	887
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

ITK_MOUSE
NC score	0.829900 (rank : 582)	θ value	4.29542e-18 (rank : 431)
Query Neighborhood Hits	1311	Target Neighborhood Hits	985	Shared Neighborhood Hits	825
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ITK_HUMAN
NC score	0.829692 (rank : 583)	θ value	1.92812e-18 (rank : 420)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1016	Shared Neighborhood Hits	824
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MRCKA_HUMAN
NC score	0.828850 (rank : 584)	θ value	2.43343e-21 (rank : 326)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1999	Shared Neighborhood Hits	1046
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

ROCK1_HUMAN
NC score	0.828673 (rank : 585)	θ value	4.9032e-22 (rank : 303)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2000	Shared Neighborhood Hits	1056
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ZAP70_MOUSE
NC score	0.828624 (rank : 586)	θ value	5.62301e-10 (rank : 694)
Query Neighborhood Hits	1311	Target Neighborhood Hits	905	Shared Neighborhood Hits	819
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

MATK_HUMAN
NC score	0.828342 (rank : 587)	θ value	1.92812e-18 (rank : 421)
Query Neighborhood Hits	1311	Target Neighborhood Hits	954	Shared Neighborhood Hits	823
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ABL1_MOUSE
NC score	0.827762 (rank : 588)	θ value	8.95645e-16 (rank : 520)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1178	Shared Neighborhood Hits	839
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_HUMAN
NC score	0.827514 (rank : 589)	θ value	3.07829e-16 (rank : 495)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1220	Shared Neighborhood Hits	844
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FAK2_MOUSE
NC score	0.827306 (rank : 590)	θ value	1.09485e-13 (rank : 587)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	807
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FRK_HUMAN
NC score	0.827199 (rank : 591)	θ value	8.10077e-17 (rank : 473)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1058	Shared Neighborhood Hits	833
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

CTRO_HUMAN
NC score	0.827087 (rank : 592)	θ value	1.74391e-19 (rank : 387)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2092	Shared Neighborhood Hits	1056
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

SRMS_MOUSE
NC score	0.826239 (rank : 593)	θ value	1.13037e-18 (rank : 418)
Query Neighborhood Hits	1311	Target Neighborhood Hits	964	Shared Neighborhood Hits	825
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

LYN_MOUSE
NC score	0.826142 (rank : 594)	θ value	1.99529e-15 (rank : 535)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1023	Shared Neighborhood Hits	838
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MYO3B_HUMAN
NC score	0.825850 (rank : 595)	θ value	1.62847e-25 (rank : 191)
Query Neighborhood Hits	1311	Target Neighborhood Hits	923	Shared Neighborhood Hits	847
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

ABL2_HUMAN
NC score	0.825593 (rank : 596)	θ value	1.16975e-15 (rank : 523)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1045	Shared Neighborhood Hits	825
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ROCK2_MOUSE
NC score	0.825545 (rank : 597)	θ value	3.17815e-21 (rank : 332)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2072	Shared Neighborhood Hits	1061
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

LYN_HUMAN
NC score	0.825533 (rank : 598)	θ value	2.60593e-15 (rank : 538)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1022	Shared Neighborhood Hits	836
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CLK1_MOUSE
NC score	0.825530 (rank : 599)	θ value	6.00763e-12 (rank : 627)
Query Neighborhood Hits	1311	Target Neighborhood Hits	760	Shared Neighborhood Hits	749
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

CLK1_HUMAN
NC score	0.824483 (rank : 600)	θ value	1.09485e-13 (rank : 586)
Query Neighborhood Hits	1311	Target Neighborhood Hits	756	Shared Neighborhood Hits	742
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

BTK_HUMAN
NC score	0.823270 (rank : 601)	θ value	4.02038e-16 (rank : 501)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1026	Shared Neighborhood Hits	816
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
NC score	0.823217 (rank : 602)	θ value	4.02038e-16 (rank : 502)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1017	Shared Neighborhood Hits	818
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CLK4_HUMAN
NC score	0.822723 (rank : 603)	θ value	3.76295e-14 (rank : 576)
Query Neighborhood Hits	1311	Target Neighborhood Hits	759	Shared Neighborhood Hits	749
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

FAK2_HUMAN
NC score	0.822493 (rank : 604)	θ value	3.18553e-13 (rank : 596)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	804
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

TXK_MOUSE
NC score	0.821301 (rank : 605)	θ value	2.13179e-17 (rank : 454)
Query Neighborhood Hits	1311	Target Neighborhood Hits	980	Shared Neighborhood Hits	808
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

CLK4_MOUSE
NC score	0.821086 (rank : 606)	θ value	4.91457e-14 (rank : 579)
Query Neighborhood Hits	1311	Target Neighborhood Hits	759	Shared Neighborhood Hits	748
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

LCK_MOUSE
NC score	0.819831 (rank : 607)	θ value	3.07829e-16 (rank : 498)
Query Neighborhood Hits	1311	Target Neighborhood Hits	981	Shared Neighborhood Hits	826
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

SRMS_HUMAN
NC score	0.819407 (rank : 608)	θ value	2.60593e-15 (rank : 541)
Query Neighborhood Hits	1311	Target Neighborhood Hits	946	Shared Neighborhood Hits	825
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

TRIB2_HUMAN
NC score	0.818664 (rank : 609)	θ value	1.25267e-09 (rank : 706)
Query Neighborhood Hits	1311	Target Neighborhood Hits	657	Shared Neighborhood Hits	653
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
NC score	0.817898 (rank : 610)	θ value	1.25267e-09 (rank : 707)
Query Neighborhood Hits	1311	Target Neighborhood Hits	653	Shared Neighborhood Hits	649
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

MRCKB_MOUSE
NC score	0.816322 (rank : 611)	θ value	2.43343e-21 (rank : 327)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2180	Shared Neighborhood Hits	1068
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

LCK_HUMAN
NC score	0.814999 (rank : 612)	θ value	5.25075e-16 (rank : 513)
Query Neighborhood Hits	1311	Target Neighborhood Hits	987	Shared Neighborhood Hits	827
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

ROCK1_MOUSE
NC score	0.813900 (rank : 613)	θ value	4.9032e-22 (rank : 304)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2126	Shared Neighborhood Hits	1072
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

BLK_HUMAN
NC score	0.813693 (rank : 614)	θ value	1.42992e-13 (rank : 588)
Query Neighborhood Hits	1311	Target Neighborhood Hits	994	Shared Neighborhood Hits	828
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CLK2_HUMAN
NC score	0.813449 (rank : 615)	θ value	3.52202e-12 (rank : 624)
Query Neighborhood Hits	1311	Target Neighborhood Hits	752	Shared Neighborhood Hits	739
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

LRRK1_HUMAN
NC score	0.811753 (rank : 616)	θ value	4.0297e-08 (rank : 752)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1237	Shared Neighborhood Hits	814
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

HCK_HUMAN
NC score	0.811217 (rank : 617)	θ value	9.90251e-15 (rank : 560)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1035	Shared Neighborhood Hits	831
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FYN_HUMAN
NC score	0.811135 (rank : 618)	θ value	2.7842e-17 (rank : 455)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1078	Shared Neighborhood Hits	831
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

PINK1_MOUSE
NC score	0.811029 (rank : 619)	θ value	0.0113563 (rank : 839)
Query Neighborhood Hits	1311	Target Neighborhood Hits	726	Shared Neighborhood Hits	723
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

LRRK1_MOUSE
NC score	0.810348 (rank : 620)	θ value	8.11959e-09 (rank : 740)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1267	Shared Neighborhood Hits	819
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

BLK_MOUSE
NC score	0.810218 (rank : 621)	θ value	7.09661e-13 (rank : 599)
Query Neighborhood Hits	1311	Target Neighborhood Hits	992	Shared Neighborhood Hits	827
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CTRO_MOUSE
NC score	0.808958 (rank : 622)	θ value	1.86321e-21 (rank : 323)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2344	Shared Neighborhood Hits	1094
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

TNK1_MOUSE
NC score	0.808602 (rank : 623)	θ value	3.29651e-10 (rank : 690)
Query Neighborhood Hits	1311	Target Neighborhood Hits	806	Shared Neighborhood Hits	774
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

MRCKB_HUMAN
NC score	0.808321 (rank : 624)	θ value	4.43474e-23 (rank : 272)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2239	Shared Neighborhood Hits	1075
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

RET_HUMAN
NC score	0.807937 (rank : 625)	θ value	2.0648e-12 (rank : 622)
Query Neighborhood Hits	1311	Target Neighborhood Hits	873	Shared Neighborhood Hits	806
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

HCK_MOUSE
NC score	0.807810 (rank : 626)	θ value	2.88119e-14 (rank : 573)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1029	Shared Neighborhood Hits	828
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

SRC_MOUSE
NC score	0.807804 (rank : 627)	θ value	3.28887e-18 (rank : 429)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1033	Shared Neighborhood Hits	823
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

RET_MOUSE
NC score	0.807286 (rank : 628)	θ value	6.00763e-12 (rank : 629)
Query Neighborhood Hits	1311	Target Neighborhood Hits	884	Shared Neighborhood Hits	803
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

SRC_HUMAN
NC score	0.806350 (rank : 629)	θ value	3.28887e-18 (rank : 428)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1058	Shared Neighborhood Hits	825
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FYN_MOUSE
NC score	0.805330 (rank : 630)	θ value	1.80466e-16 (rank : 485)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1073	Shared Neighborhood Hits	834
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

EPHA5_MOUSE
NC score	0.802360 (rank : 631)	θ value	7.58209e-15 (rank : 558)
Query Neighborhood Hits	1311	Target Neighborhood Hits	950	Shared Neighborhood Hits	814
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

TNK1_HUMAN
NC score	0.801994 (rank : 632)	θ value	7.84624e-12 (rank : 632)
Query Neighborhood Hits	1311	Target Neighborhood Hits	815	Shared Neighborhood Hits	773
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

YES_HUMAN
NC score	0.800726 (rank : 633)	θ value	2.88119e-14 (rank : 575)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1059	Shared Neighborhood Hits	823
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.800212 (rank : 634)	θ value	3.76295e-14 (rank : 578)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1052	Shared Neighborhood Hits	822
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGFR2_MOUSE
NC score	0.800116 (rank : 635)	θ value	6.85773e-16 (rank : 515)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1062	Shared Neighborhood Hits	819
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

ACK1_HUMAN
NC score	0.799992 (rank : 636)	θ value	3.89403e-11 (rank : 659)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1140	Shared Neighborhood Hits	828
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
NC score	0.799313 (rank : 637)	θ value	5.08577e-11 (rank : 662)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1080	Shared Neighborhood Hits	823
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

EGFR_MOUSE
NC score	0.798932 (rank : 638)	θ value	3.89403e-11 (rank : 661)
Query Neighborhood Hits	1311	Target Neighborhood Hits	927	Shared Neighborhood Hits	811
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

ERBB4_HUMAN
NC score	0.798844 (rank : 639)	θ value	1.2105e-12 (rank : 611)
Query Neighborhood Hits	1311	Target Neighborhood Hits	910	Shared Neighborhood Hits	800
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

CLK2_MOUSE
NC score	0.798464 (rank : 640)	θ value	2.98157e-11 (rank : 653)
Query Neighborhood Hits	1311	Target Neighborhood Hits	743	Shared Neighborhood Hits	733
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

EGFR_HUMAN
NC score	0.798406 (rank : 641)	θ value	5.08577e-11 (rank : 663)
Query Neighborhood Hits	1311	Target Neighborhood Hits	939	Shared Neighborhood Hits	809
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

LRRK2_HUMAN
NC score	0.798251 (rank : 642)	θ value	1.33837e-11 (rank : 642)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1382	Shared Neighborhood Hits	833
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

FGFR2_HUMAN
NC score	0.797720 (rank : 643)	θ value	6.85773e-16 (rank : 514)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1062	Shared Neighborhood Hits	819
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

PINK1_HUMAN
NC score	0.797707 (rank : 644)	θ value	0.00035302 (rank : 809)
Query Neighborhood Hits	1311	Target Neighborhood Hits	741	Shared Neighborhood Hits	720
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

NTRK2_HUMAN
NC score	0.796293 (rank : 645)	θ value	1.16975e-15 (rank : 524)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1081	Shared Neighborhood Hits	809
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
NC score	0.796189 (rank : 646)	θ value	2.35696e-16 (rank : 493)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1088	Shared Neighborhood Hits	809
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

RON_HUMAN
NC score	0.795508 (rank : 647)	θ value	2.98157e-11 (rank : 656)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	804
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

FGFR1_MOUSE
NC score	0.794146 (rank : 648)	θ value	1.80466e-16 (rank : 484)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1068	Shared Neighborhood Hits	820
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.794015 (rank : 649)	θ value	1.80466e-16 (rank : 483)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1069	Shared Neighborhood Hits	820
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

CLK3_HUMAN
NC score	0.793676 (rank : 650)	θ value	7.84624e-12 (rank : 630)
Query Neighborhood Hits	1311	Target Neighborhood Hits	748	Shared Neighborhood Hits	731
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

FGR_HUMAN
NC score	0.793187 (rank : 651)	θ value	2.88119e-14 (rank : 572)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1067	Shared Neighborhood Hits	830
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

CLK3_MOUSE
NC score	0.793068 (rank : 652)	θ value	7.84624e-12 (rank : 631)
Query Neighborhood Hits	1311	Target Neighborhood Hits	761	Shared Neighborhood Hits	732
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

MET_MOUSE
NC score	0.790503 (rank : 653)	θ value	7.09661e-13 (rank : 605)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	798
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

TIE2_HUMAN
NC score	0.790419 (rank : 654)	θ value	4.44505e-15 (rank : 549)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1192	Shared Neighborhood Hits	812
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

EPHB1_HUMAN
NC score	0.790251 (rank : 655)	θ value	3.52202e-12 (rank : 625)
Query Neighborhood Hits	1311	Target Neighborhood Hits	988	Shared Neighborhood Hits	811
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

FGR_MOUSE
NC score	0.789361 (rank : 656)	θ value	1.58096e-12 (rank : 614)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1069	Shared Neighborhood Hits	828
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TIE2_MOUSE
NC score	0.789319 (rank : 657)	θ value	5.8054e-15 (rank : 556)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1204	Shared Neighborhood Hits	812
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

STYK1_HUMAN
NC score	0.789202 (rank : 658)	θ value	5.08577e-11 (rank : 666)
Query Neighborhood Hits	1311	Target Neighborhood Hits	786	Shared Neighborhood Hits	773
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

FGFR3_HUMAN
NC score	0.788856 (rank : 659)	θ value	5.60996e-18 (rank : 433)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1042	Shared Neighborhood Hits	817
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

ERBB2_MOUSE
NC score	0.788359 (rank : 660)	θ value	5.08577e-11 (rank : 664)
Query Neighborhood Hits	1311	Target Neighborhood Hits	918	Shared Neighborhood Hits	810
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

MET_HUMAN
NC score	0.787950 (rank : 661)	θ value	2.0648e-12 (rank : 620)
Query Neighborhood Hits	1311	Target Neighborhood Hits	831	Shared Neighborhood Hits	796
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

AVR2A_MOUSE
NC score	0.787622 (rank : 662)	θ value	1.63604e-09 (rank : 709)
Query Neighborhood Hits	1311	Target Neighborhood Hits	767	Shared Neighborhood Hits	763
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.787608 (rank : 663)	θ value	1.63604e-09 (rank : 708)
Query Neighborhood Hits	1311	Target Neighborhood Hits	767	Shared Neighborhood Hits	763
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

EPHA3_HUMAN
NC score	0.786616 (rank : 664)	θ value	8.95645e-16 (rank : 522)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1005	Shared Neighborhood Hits	816
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

TNI3K_MOUSE
NC score	0.786313 (rank : 665)	θ value	1.16975e-15 (rank : 526)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1079	Shared Neighborhood Hits	792
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

RON_MOUSE
NC score	0.785283 (rank : 666)	θ value	3.52202e-12 (rank : 626)
Query Neighborhood Hits	1311	Target Neighborhood Hits	836	Shared Neighborhood Hits	797
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ERBB2_HUMAN
NC score	0.784747 (rank : 667)	θ value	8.67504e-11 (rank : 671)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1073	Shared Neighborhood Hits	815
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

FGFR3_MOUSE
NC score	0.784196 (rank : 668)	θ value	3.07829e-16 (rank : 496)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1059	Shared Neighborhood Hits	818
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

MLKL_MOUSE
NC score	0.783978 (rank : 669)	θ value	4.30538e-10 (rank : 691)
Query Neighborhood Hits	1311	Target Neighborhood Hits	707	Shared Neighborhood Hits	697
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

TGFR2_HUMAN
NC score	0.783146 (rank : 670)	θ value	7.59969e-07 (rank : 772)
Query Neighborhood Hits	1311	Target Neighborhood Hits	748	Shared Neighborhood Hits	741
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
NC score	0.782980 (rank : 671)	θ value	5.81887e-07 (rank : 769)
Query Neighborhood Hits	1311	Target Neighborhood Hits	748	Shared Neighborhood Hits	742
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

EPHA7_MOUSE
NC score	0.782423 (rank : 672)	θ value	5.8054e-15 (rank : 551)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1025	Shared Neighborhood Hits	821
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

AATK_HUMAN
NC score	0.782372 (rank : 673)	θ value	1.33837e-11 (rank : 638)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1243	Shared Neighborhood Hits	790
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

EPHA5_HUMAN
NC score	0.781710 (rank : 674)	θ value	3.40345e-15 (rank : 543)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	814
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA7_HUMAN
NC score	0.781311 (rank : 675)	θ value	5.8054e-15 (rank : 550)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1053	Shared Neighborhood Hits	820
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA2_HUMAN
NC score	0.780676 (rank : 676)	θ value	5.25075e-16 (rank : 511)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1021	Shared Neighborhood Hits	819
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA3_MOUSE
NC score	0.779821 (rank : 677)	θ value	2.60593e-15 (rank : 536)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1009	Shared Neighborhood Hits	820
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHB4_MOUSE
NC score	0.779475 (rank : 678)	θ value	2.0648e-12 (rank : 618)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1013	Shared Neighborhood Hits	807
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHA2_MOUSE
NC score	0.779458 (rank : 679)	θ value	3.40345e-15 (rank : 542)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1020	Shared Neighborhood Hits	814
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

TRIB1_HUMAN
NC score	0.779406 (rank : 680)	θ value	2.98157e-11 (rank : 657)
Query Neighborhood Hits	1311	Target Neighborhood Hits	598	Shared Neighborhood Hits	585
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

ROR1_MOUSE
NC score	0.779328 (rank : 681)	θ value	3.64472e-09 (rank : 731)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1025	Shared Neighborhood Hits	809
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

LRRK2_MOUSE
NC score	0.779028 (rank : 682)	θ value	1.133e-10 (rank : 673)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1359	Shared Neighborhood Hits	823
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

TNI3K_HUMAN
NC score	0.778961 (rank : 683)	θ value	1.52774e-15 (rank : 531)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1084	Shared Neighborhood Hits	797
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TRIB1_MOUSE
NC score	0.778347 (rank : 684)	θ value	2.28291e-11 (rank : 651)
Query Neighborhood Hits	1311	Target Neighborhood Hits	593	Shared Neighborhood Hits	587
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

ACVR1_MOUSE
NC score	0.777497 (rank : 685)	θ value	4.45536e-07 (rank : 763)
Query Neighborhood Hits	1311	Target Neighborhood Hits	768	Shared Neighborhood Hits	760
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ROR1_HUMAN
NC score	0.777476 (rank : 686)	θ value	2.13673e-09 (rank : 721)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1018	Shared Neighborhood Hits	806
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

DDR2_MOUSE
NC score	0.777248 (rank : 687)	θ value	3.64472e-09 (rank : 728)
Query Neighborhood Hits	1311	Target Neighborhood Hits	813	Shared Neighborhood Hits	776
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA1_HUMAN
NC score	0.776965 (rank : 688)	θ value	2.52405e-10 (rank : 681)
Query Neighborhood Hits	1311	Target Neighborhood Hits	997	Shared Neighborhood Hits	802
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHB4_HUMAN
NC score	0.776529 (rank : 689)	θ value	2.0648e-12 (rank : 617)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1056	Shared Neighborhood Hits	806
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

AATK_MOUSE
NC score	0.776241 (rank : 690)	θ value	2.98157e-11 (rank : 652)
Query Neighborhood Hits	1311	Target Neighborhood Hits	942	Shared Neighborhood Hits	768
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

INSR_HUMAN
NC score	0.776202 (rank : 691)	θ value	6.41864e-14 (rank : 584)
Query Neighborhood Hits	1311	Target Neighborhood Hits	963	Shared Neighborhood Hits	805
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

FGFR4_HUMAN
NC score	0.775794 (rank : 692)	θ value	1.38178e-16 (rank : 480)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1037	Shared Neighborhood Hits	804
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

STYK1_MOUSE
NC score	0.775281 (rank : 693)	θ value	1.47974e-10 (rank : 676)
Query Neighborhood Hits	1311	Target Neighborhood Hits	779	Shared Neighborhood Hits	767
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

EPHB2_MOUSE
NC score	0.775108 (rank : 694)	θ value	7.09661e-13 (rank : 601)
Query Neighborhood Hits	1311	Target Neighborhood Hits	982	Shared Neighborhood Hits	811
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.774940 (rank : 695)	θ value	7.09661e-13 (rank : 600)
Query Neighborhood Hits	1311	Target Neighborhood Hits	983	Shared Neighborhood Hits	811
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA4_HUMAN
NC score	0.774361 (rank : 696)	θ value	4.02038e-16 (rank : 503)
Query Neighborhood Hits	1311	Target Neighborhood Hits	975	Shared Neighborhood Hits	813
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

INSR_MOUSE
NC score	0.774360 (rank : 697)	θ value	7.58209e-15 (rank : 559)
Query Neighborhood Hits	1311	Target Neighborhood Hits	968	Shared Neighborhood Hits	798
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ROS_HUMAN
NC score	0.774220 (rank : 698)	θ value	5.8054e-15 (rank : 554)
Query Neighborhood Hits	1311	Target Neighborhood Hits	907	Shared Neighborhood Hits	767
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

EPHA4_MOUSE
NC score	0.774099 (rank : 699)	θ value	4.02038e-16 (rank : 504)
Query Neighborhood Hits	1311	Target Neighborhood Hits	982	Shared Neighborhood Hits	814
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

NTRK1_HUMAN
NC score	0.772771 (rank : 700)	θ value	1.58096e-12 (rank : 615)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1023	Shared Neighborhood Hits	789
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

ACVR1_HUMAN
NC score	0.772607 (rank : 701)	θ value	5.81887e-07 (rank : 766)
Query Neighborhood Hits	1311	Target Neighborhood Hits	760	Shared Neighborhood Hits	754
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

BMR1A_HUMAN
NC score	0.772110 (rank : 702)	θ value	1.63604e-09 (rank : 710)
Query Neighborhood Hits	1311	Target Neighborhood Hits	759	Shared Neighborhood Hits	749
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

DDR2_HUMAN
NC score	0.771521 (rank : 703)	θ value	1.63604e-09 (rank : 712)
Query Neighborhood Hits	1311	Target Neighborhood Hits	818	Shared Neighborhood Hits	776
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA8_HUMAN
NC score	0.770979 (rank : 704)	θ value	5.43371e-13 (rank : 598)
Query Neighborhood Hits	1311	Target Neighborhood Hits	956	Shared Neighborhood Hits	809
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

BMR1A_MOUSE
NC score	0.770915 (rank : 705)	θ value	1.63604e-09 (rank : 711)
Query Neighborhood Hits	1311	Target Neighborhood Hits	758	Shared Neighborhood Hits	749
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

TIE1_MOUSE
NC score	0.770428 (rank : 706)	θ value	2.43908e-13 (rank : 592)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1266	Shared Neighborhood Hits	813
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_HUMAN
NC score	0.768743 (rank : 707)	θ value	7.09661e-13 (rank : 608)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1241	Shared Neighborhood Hits	812
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

AVR2B_MOUSE
NC score	0.768487 (rank : 708)	θ value	4.76016e-09 (rank : 733)
Query Neighborhood Hits	1311	Target Neighborhood Hits	749	Shared Neighborhood Hits	740
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.768254 (rank : 709)	θ value	4.76016e-09 (rank : 732)
Query Neighborhood Hits	1311	Target Neighborhood Hits	748	Shared Neighborhood Hits	740
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

EPHA1_MOUSE
NC score	0.767183 (rank : 710)	θ value	7.34386e-10 (rank : 695)
Query Neighborhood Hits	1311	Target Neighborhood Hits	958	Shared Neighborhood Hits	791
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA8_MOUSE
NC score	0.765759 (rank : 711)	θ value	9.26847e-13 (rank : 609)
Query Neighborhood Hits	1311	Target Neighborhood Hits	969	Shared Neighborhood Hits	806
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

UFO_MOUSE
NC score	0.765497 (rank : 712)	θ value	1.2105e-12 (rank : 613)
Query Neighborhood Hits	1311	Target Neighborhood Hits	988	Shared Neighborhood Hits	764
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

TRIB3_MOUSE
NC score	0.764916 (rank : 713)	θ value	6.43352e-06 (rank : 782)
Query Neighborhood Hits	1311	Target Neighborhood Hits	578	Shared Neighborhood Hits	574
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

NTRK3_HUMAN
NC score	0.764524 (rank : 714)	θ value	7.09661e-13 (rank : 606)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1115	Shared Neighborhood Hits	796
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

EPHB3_HUMAN
NC score	0.764242 (rank : 715)	θ value	1.74796e-11 (rank : 645)
Query Neighborhood Hits	1311	Target Neighborhood Hits	996	Shared Neighborhood Hits	812
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

ERBB3_MOUSE
NC score	0.763932 (rank : 716)	θ value	1.9326e-10 (rank : 678)
Query Neighborhood Hits	1311	Target Neighborhood Hits	898	Shared Neighborhood Hits	776
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

EPHB3_MOUSE
NC score	0.762977 (rank : 717)	θ value	6.64225e-11 (rank : 667)
Query Neighborhood Hits	1311	Target Neighborhood Hits	996	Shared Neighborhood Hits	813
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

RPKL1_MOUSE
NC score	0.761940 (rank : 718)	θ value	3.41135e-07 (rank : 761)
Query Neighborhood Hits	1311	Target Neighborhood Hits	704	Shared Neighborhood Hits	654
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

UFO_HUMAN
NC score	0.761169 (rank : 719)	θ value	1.58096e-12 (rank : 616)
Query Neighborhood Hits	1311	Target Neighborhood Hits	981	Shared Neighborhood Hits	765
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

BMR1B_MOUSE
NC score	0.760692 (rank : 720)	θ value	2.79066e-09 (rank : 723)
Query Neighborhood Hits	1311	Target Neighborhood Hits	758	Shared Neighborhood Hits	748
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

ERBB3_HUMAN
NC score	0.760391 (rank : 721)	θ value	2.28291e-11 (rank : 647)
Query Neighborhood Hits	1311	Target Neighborhood Hits	918	Shared Neighborhood Hits	775
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

IGF1R_MOUSE
NC score	0.760309 (rank : 722)	θ value	9.90251e-15 (rank : 561)
Query Neighborhood Hits	1311	Target Neighborhood Hits	973	Shared Neighborhood Hits	788
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

BMR1B_HUMAN
NC score	0.759091 (rank : 723)	θ value	3.64472e-09 (rank : 727)
Query Neighborhood Hits	1311	Target Neighborhood Hits	760	Shared Neighborhood Hits	747
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

IGF1R_HUMAN
NC score	0.758466 (rank : 724)	θ value	3.76295e-14 (rank : 577)
Query Neighborhood Hits	1311	Target Neighborhood Hits	977	Shared Neighborhood Hits	788
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

TOPK_MOUSE
NC score	0.758321 (rank : 725)	θ value	6.85773e-16 (rank : 519)
Query Neighborhood Hits	1311	Target Neighborhood Hits	618	Shared Neighborhood Hits	608
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

INSRR_MOUSE
NC score	0.758009 (rank : 726)	θ value	5.8054e-15 (rank : 553)
Query Neighborhood Hits	1311	Target Neighborhood Hits	961	Shared Neighborhood Hits	779
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

TGFR1_HUMAN
NC score	0.757356 (rank : 727)	θ value	2.52405e-10 (rank : 686)
Query Neighborhood Hits	1311	Target Neighborhood Hits	755	Shared Neighborhood Hits	749
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TYRO3_HUMAN
NC score	0.757106 (rank : 728)	θ value	1.2105e-12 (rank : 612)
Query Neighborhood Hits	1311	Target Neighborhood Hits	995	Shared Neighborhood Hits	775
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TGFR1_MOUSE
NC score	0.756982 (rank : 729)	θ value	2.52405e-10 (rank : 687)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	749
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

TYRO3_MOUSE
NC score	0.756336 (rank : 730)	θ value	7.84624e-12 (rank : 633)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1007	Shared Neighborhood Hits	774
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ROR2_HUMAN
NC score	0.755949 (rank : 731)	θ value	1.63604e-09 (rank : 718)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1014	Shared Neighborhood Hits	791
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

INSRR_HUMAN
NC score	0.755400 (rank : 732)	θ value	5.8054e-15 (rank : 552)
Query Neighborhood Hits	1311	Target Neighborhood Hits	950	Shared Neighborhood Hits	779
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

RPKL1_HUMAN
NC score	0.755145 (rank : 733)	θ value	6.43352e-06 (rank : 781)
Query Neighborhood Hits	1311	Target Neighborhood Hits	708	Shared Neighborhood Hits	655
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

FGFR4_MOUSE
NC score	0.754617 (rank : 734)	θ value	2.60593e-15 (rank : 537)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1026	Shared Neighborhood Hits	792
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

MERTK_MOUSE
NC score	0.754420 (rank : 735)	θ value	3.18553e-13 (rank : 597)
Query Neighborhood Hits	1311	Target Neighborhood Hits	974	Shared Neighborhood Hits	765
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

ACV1B_MOUSE
NC score	0.752446 (rank : 736)	θ value	6.21693e-09 (rank : 738)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	748
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.752338 (rank : 737)	θ value	6.21693e-09 (rank : 737)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	749
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

DDR1_MOUSE
NC score	0.752112 (rank : 738)	θ value	2.69671e-12 (rank : 623)
Query Neighborhood Hits	1311	Target Neighborhood Hits	818	Shared Neighborhood Hits	768
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR1_HUMAN
NC score	0.749236 (rank : 739)	θ value	1.02475e-11 (rank : 634)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	769
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

TOPK_HUMAN
NC score	0.749145 (rank : 740)	θ value	5.8054e-15 (rank : 557)
Query Neighborhood Hits	1311	Target Neighborhood Hits	605	Shared Neighborhood Hits	597
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

TTBK1_HUMAN
NC score	0.748367 (rank : 741)	θ value	0.000121331 (rank : 801)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1058	Shared Neighborhood Hits	740
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

MERTK_HUMAN
NC score	0.747856 (rank : 742)	θ value	7.09661e-13 (rank : 604)
Query Neighborhood Hits	1311	Target Neighborhood Hits	988	Shared Neighborhood Hits	771
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

BMPR2_HUMAN
NC score	0.744756 (rank : 743)	θ value	2.88788e-06 (rank : 774)
Query Neighborhood Hits	1311	Target Neighborhood Hits	736	Shared Neighborhood Hits	710
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

ALK_HUMAN
NC score	0.743162 (rank : 744)	θ value	1.9326e-10 (rank : 677)
Query Neighborhood Hits	1311	Target Neighborhood Hits	795	Shared Neighborhood Hits	742
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

IRAK2_HUMAN
NC score	0.742579 (rank : 745)	θ value	0.00298849 (rank : 823)
Query Neighborhood Hits	1311	Target Neighborhood Hits	714	Shared Neighborhood Hits	678
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

BMPR2_MOUSE
NC score	0.742125 (rank : 746)	θ value	1.09739e-05 (rank : 784)
Query Neighborhood Hits	1311	Target Neighborhood Hits	738	Shared Neighborhood Hits	709
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

ACVL1_MOUSE
NC score	0.741771 (rank : 747)	θ value	1.87187e-05 (rank : 788)
Query Neighborhood Hits	1311	Target Neighborhood Hits	739	Shared Neighborhood Hits	736
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ALK_MOUSE
NC score	0.740266 (rank : 748)	θ value	1.25267e-09 (rank : 703)
Query Neighborhood Hits	1311	Target Neighborhood Hits	811	Shared Neighborhood Hits	744
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

LTK_MOUSE
NC score	0.738857 (rank : 749)	θ value	8.11959e-09 (rank : 741)
Query Neighborhood Hits	1311	Target Neighborhood Hits	770	Shared Neighborhood Hits	744
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

KS6C1_MOUSE
NC score	0.737656 (rank : 750)	θ value	5.81887e-07 (rank : 767)
Query Neighborhood Hits	1311	Target Neighborhood Hits	700	Shared Neighborhood Hits	635
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

PGFRA_HUMAN
NC score	0.736483 (rank : 751)	θ value	6.87365e-08 (rank : 753)
Query Neighborhood Hits	1311	Target Neighborhood Hits	980	Shared Neighborhood Hits	796
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

TTBK2_HUMAN
NC score	0.736422 (rank : 752)	θ value	0.00020696 (rank : 806)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	705
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

PGFRA_MOUSE
NC score	0.735284 (rank : 753)	θ value	2.36244e-08 (rank : 749)
Query Neighborhood Hits	1311	Target Neighborhood Hits	975	Shared Neighborhood Hits	792
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

TTBK2_MOUSE
NC score	0.734221 (rank : 754)	θ value	0.000158464 (rank : 805)
Query Neighborhood Hits	1311	Target Neighborhood Hits	811	Shared Neighborhood Hits	697
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

CDC7_HUMAN
NC score	0.734032 (rank : 755)	θ value	0.000121331 (rank : 798)
Query Neighborhood Hits	1311	Target Neighborhood Hits	652	Shared Neighborhood Hits	634
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

LTK_HUMAN
NC score	0.733575 (rank : 756)	θ value	6.21693e-09 (rank : 739)
Query Neighborhood Hits	1311	Target Neighborhood Hits	774	Shared Neighborhood Hits	751
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

EPHA6_MOUSE
NC score	0.733264 (rank : 757)	θ value	3.18553e-13 (rank : 595)
Query Neighborhood Hits	1311	Target Neighborhood Hits	946	Shared Neighborhood Hits	803
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

TRIB3_HUMAN
NC score	0.732134 (rank : 758)	θ value	0.00102713 (rank : 813)
Query Neighborhood Hits	1311	Target Neighborhood Hits	519	Shared Neighborhood Hits	515
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

VGFR3_MOUSE
NC score	0.732109 (rank : 759)	θ value	1.38499e-08 (rank : 744)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1056	Shared Neighborhood Hits	793
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

KS6C1_HUMAN
NC score	0.731985 (rank : 760)	θ value	1.09739e-05 (rank : 785)
Query Neighborhood Hits	1311	Target Neighborhood Hits	682	Shared Neighborhood Hits	637
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

ROR2_MOUSE
NC score	0.731925 (rank : 761)	θ value	9.59137e-10 (rank : 701)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1000	Shared Neighborhood Hits	768
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

KIT_HUMAN
NC score	0.731623 (rank : 762)	θ value	7.34386e-10 (rank : 696)
Query Neighborhood Hits	1311	Target Neighborhood Hits	953	Shared Neighborhood Hits	795
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

VGFR3_HUMAN
NC score	0.729927 (rank : 763)	θ value	1.80886e-08 (rank : 746)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1037	Shared Neighborhood Hits	795
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

EPHA6_HUMAN
NC score	0.728209 (rank : 764)	θ value	3.18553e-13 (rank : 594)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	799
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

VGFR1_MOUSE
NC score	0.728096 (rank : 765)	θ value	2.98157e-11 (rank : 658)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1118	Shared Neighborhood Hits	809
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

PTK7_HUMAN
NC score	0.727461 (rank : 766)	θ value	1.52774e-15 (rank : 530)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1103	Shared Neighborhood Hits	785
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

FLT3_HUMAN
NC score	0.726896 (rank : 767)	θ value	9.92553e-07 (rank : 773)
Query Neighborhood Hits	1311	Target Neighborhood Hits	843	Shared Neighborhood Hits	787
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

PGFRB_HUMAN
NC score	0.726809 (rank : 768)	θ value	2.88788e-06 (rank : 775)
Query Neighborhood Hits	1311	Target Neighborhood Hits	962	Shared Neighborhood Hits	787
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
NC score	0.725393 (rank : 769)	θ value	6.43352e-06 (rank : 780)
Query Neighborhood Hits	1311	Target Neighborhood Hits	960	Shared Neighborhood Hits	791
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

KIT_MOUSE
NC score	0.725181 (rank : 770)	θ value	3.64472e-09 (rank : 730)
Query Neighborhood Hits	1311	Target Neighborhood Hits	949	Shared Neighborhood Hits	793
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

CDC7_MOUSE
NC score	0.725121 (rank : 771)	θ value	3.19293e-05 (rank : 791)
Query Neighborhood Hits	1311	Target Neighborhood Hits	641	Shared Neighborhood Hits	631
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

IRAK3_MOUSE
NC score	0.724113 (rank : 772)	θ value	4.45536e-07 (rank : 764)
Query Neighborhood Hits	1311	Target Neighborhood Hits	628	Shared Neighborhood Hits	610
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

FLT3_MOUSE
NC score	0.723644 (rank : 773)	θ value	4.76016e-09 (rank : 736)
Query Neighborhood Hits	1311	Target Neighborhood Hits	847	Shared Neighborhood Hits	788
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

TITIN_HUMAN
NC score	0.722421 (rank : 774)	θ value	1.09232e-21 (rank : 311)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2923	Shared Neighborhood Hits	995
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

VGFR2_MOUSE
NC score	0.721458 (rank : 775)	θ value	6.87365e-08 (rank : 754)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1089	Shared Neighborhood Hits	798
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR1_HUMAN
NC score	0.721334 (rank : 776)	θ value	6.64225e-11 (rank : 669)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1109	Shared Neighborhood Hits	805
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ACVL1_HUMAN
NC score	0.721255 (rank : 777)	θ value	7.1131e-05 (rank : 794)
Query Neighborhood Hits	1311	Target Neighborhood Hits	716	Shared Neighborhood Hits	711
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

MUSK_HUMAN
NC score	0.718707 (rank : 778)	θ value	1.02475e-11 (rank : 637)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1074	Shared Neighborhood Hits	786
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

VGFR2_HUMAN
NC score	0.716605 (rank : 779)	θ value	3.41135e-07 (rank : 762)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1103	Shared Neighborhood Hits	799
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

IRAK3_HUMAN
NC score	0.716503 (rank : 780)	θ value	8.40245e-06 (rank : 783)
Query Neighborhood Hits	1311	Target Neighborhood Hits	644	Shared Neighborhood Hits	632
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

KC1AL_HUMAN
NC score	0.713974 (rank : 781)	θ value	0.000158464 (rank : 804)
Query Neighborhood Hits	1311	Target Neighborhood Hits	734	Shared Neighborhood Hits	727
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

MUSK_MOUSE
NC score	0.713596 (rank : 782)	θ value	1.9326e-10 (rank : 679)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1057	Shared Neighborhood Hits	783
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

KC1A_HUMAN
NC score	0.713142 (rank : 783)	θ value	0.00102713 (rank : 811)
Query Neighborhood Hits	1311	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.713142 (rank : 784)	θ value	0.00102713 (rank : 812)
Query Neighborhood Hits	1311	Target Neighborhood Hits	728	Shared Neighborhood Hits	724
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1D_HUMAN
NC score	0.711619 (rank : 785)	θ value	0.163984 (rank : 905)
Query Neighborhood Hits	1311	Target Neighborhood Hits	737	Shared Neighborhood Hits	721
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.711607 (rank : 786)	θ value	0.163984 (rank : 906)
Query Neighborhood Hits	1311	Target Neighborhood Hits	737	Shared Neighborhood Hits	721
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
NC score	0.708808 (rank : 787)	θ value	0.0113563 (rank : 836)
Query Neighborhood Hits	1311	Target Neighborhood Hits	732	Shared Neighborhood Hits	723
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
NC score	0.708782 (rank : 788)	θ value	0.0113563 (rank : 837)
Query Neighborhood Hits	1311	Target Neighborhood Hits	728	Shared Neighborhood Hits	723
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

ANKK1_MOUSE
NC score	0.707204 (rank : 789)	θ value	5.62301e-10 (rank : 693)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1072	Shared Neighborhood Hits	795
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

CSF1R_HUMAN
NC score	0.702307 (rank : 790)	θ value	4.76016e-09 (rank : 734)
Query Neighborhood Hits	1311	Target Neighborhood Hits	943	Shared Neighborhood Hits	790
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ACV1C_MOUSE
NC score	0.702212 (rank : 791)	θ value	7.59969e-07 (rank : 770)
Query Neighborhood Hits	1311	Target Neighborhood Hits	715	Shared Neighborhood Hits	702
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

RIPK4_HUMAN
NC score	0.698691 (rank : 792)	θ value	2.98157e-11 (rank : 655)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1094	Shared Neighborhood Hits	801
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

MLKL_HUMAN
NC score	0.698163 (rank : 793)	θ value	2.28291e-11 (rank : 649)
Query Neighborhood Hits	1311	Target Neighborhood Hits	600	Shared Neighborhood Hits	588
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

ACV1C_HUMAN
NC score	0.698005 (rank : 794)	θ value	1.17247e-07 (rank : 757)
Query Neighborhood Hits	1311	Target Neighborhood Hits	709	Shared Neighborhood Hits	695
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

KC1G1_MOUSE
NC score	0.697788 (rank : 795)	θ value	0.0193708 (rank : 844)
Query Neighborhood Hits	1311	Target Neighborhood Hits	713	Shared Neighborhood Hits	705
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_HUMAN
NC score	0.696018 (rank : 796)	θ value	0.0431538 (rank : 858)
Query Neighborhood Hits	1311	Target Neighborhood Hits	708	Shared Neighborhood Hits	703
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

CSF1R_MOUSE
NC score	0.695899 (rank : 797)	θ value	9.59137e-10 (rank : 698)
Query Neighborhood Hits	1311	Target Neighborhood Hits	983	Shared Neighborhood Hits	790
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ANKK1_HUMAN
NC score	0.693517 (rank : 798)	θ value	5.62301e-10 (rank : 692)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1075	Shared Neighborhood Hits	791
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

RYK_MOUSE
NC score	0.691198 (rank : 799)	θ value	7.59969e-07 (rank : 771)
Query Neighborhood Hits	1311	Target Neighborhood Hits	715	Shared Neighborhood Hits	703
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

KC1G3_HUMAN
NC score	0.690229 (rank : 800)	θ value	0.0113563 (rank : 838)
Query Neighborhood Hits	1311	Target Neighborhood Hits	711	Shared Neighborhood Hits	706
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

RYK_HUMAN
NC score	0.675811 (rank : 801)	θ value	3.77169e-06 (rank : 777)
Query Neighborhood Hits	1311	Target Neighborhood Hits	701	Shared Neighborhood Hits	691
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

EPHAA_HUMAN
NC score	0.675768 (rank : 802)	θ value	2.13673e-09 (rank : 719)
Query Neighborhood Hits	1311	Target Neighborhood Hits	960	Shared Neighborhood Hits	739
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

KC1G2_MOUSE
NC score	0.664098 (rank : 803)	θ value	0.00509761 (rank : 828)
Query Neighborhood Hits	1311	Target Neighborhood Hits	695	Shared Neighborhood Hits	690
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

EPHB6_MOUSE
NC score	0.663390 (rank : 804)	θ value	0.000158464 (rank : 802)
Query Neighborhood Hits	1311	Target Neighborhood Hits	906	Shared Neighborhood Hits	710
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

KC1G2_HUMAN
NC score	0.663166 (rank : 805)	θ value	0.00134147 (rank : 816)
Query Neighborhood Hits	1311	Target Neighborhood Hits	693	Shared Neighborhood Hits	690
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

SCYL2_HUMAN
NC score	0.648682 (rank : 806)	θ value	0.0252991 (rank : 851)
Query Neighborhood Hits	1311	Target Neighborhood Hits	632	Shared Neighborhood Hits	577
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

AMHR2_HUMAN
NC score	0.647515 (rank : 807)	θ value	0.00175202 (rank : 818)
Query Neighborhood Hits	1311	Target Neighborhood Hits	715	Shared Neighborhood Hits	660
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

EPHB6_HUMAN
NC score	0.646980 (rank : 808)	θ value	7.1131e-05 (rank : 795)
Query Neighborhood Hits	1311	Target Neighborhood Hits	912	Shared Neighborhood Hits	683
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

GUC2F_HUMAN
NC score	0.633043 (rank : 809)	θ value	0.000270298 (rank : 807)
Query Neighborhood Hits	1311	Target Neighborhood Hits	740	Shared Neighborhood Hits	679
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

SCYL2_MOUSE
NC score	0.626752 (rank : 810)	θ value	0.0431538 (rank : 860)
Query Neighborhood Hits	1311	Target Neighborhood Hits	603	Shared Neighborhood Hits	551
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

BUB1_MOUSE
NC score	0.602071 (rank : 811)	θ value	0.00665767 (rank : 829)
Query Neighborhood Hits	1311	Target Neighborhood Hits	583	Shared Neighborhood Hits	543
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

GUC2C_HUMAN
NC score	0.590252 (rank : 812)	θ value	4.1701e-05 (rank : 793)
Query Neighborhood Hits	1311	Target Neighborhood Hits	624	Shared Neighborhood Hits	586
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

TEX14_MOUSE
NC score	0.583784 (rank : 813)	θ value	0.00298849 (rank : 824)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1333	Shared Neighborhood Hits	778
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

NRBP_HUMAN
NC score	0.581010 (rank : 814)	θ value	1.53129e-07 (rank : 759)
Query Neighborhood Hits	1311	Target Neighborhood Hits	448	Shared Neighborhood Hits	425
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

NRBP_MOUSE
NC score	0.578454 (rank : 815)	θ value	1.53129e-07 (rank : 760)
Query Neighborhood Hits	1311	Target Neighborhood Hits	442	Shared Neighborhood Hits	421
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

GUC2D_HUMAN
NC score	0.574648 (rank : 816)	θ value	0.0431538 (rank : 857)
Query Neighborhood Hits	1311	Target Neighborhood Hits	715	Shared Neighborhood Hits	666
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

ANPRB_HUMAN
NC score	0.570672 (rank : 817)	θ value	θ > 10 (rank : 1313)
Query Neighborhood Hits	1311	Target Neighborhood Hits	646	Shared Neighborhood Hits	585
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

SRPK1_MOUSE
NC score	0.569756 (rank : 818)	θ value	0.21417 (rank : 916)
Query Neighborhood Hits	1311	Target Neighborhood Hits	639	Shared Neighborhood Hits	584
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_HUMAN
NC score	0.567231 (rank : 819)	θ value	0.21417 (rank : 915)
Query Neighborhood Hits	1311	Target Neighborhood Hits	706	Shared Neighborhood Hits	603
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

GUC2G_MOUSE
NC score	0.559499 (rank : 820)	θ value	0.00175202 (rank : 820)
Query Neighborhood Hits	1311	Target Neighborhood Hits	644	Shared Neighborhood Hits	585
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

SRPK2_HUMAN
NC score	0.558616 (rank : 821)	θ value	1.06291 (rank : 1025)
Query Neighborhood Hits	1311	Target Neighborhood Hits	664	Shared Neighborhood Hits	592
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
NC score	0.557795 (rank : 822)	θ value	1.06291 (rank : 1026)
Query Neighborhood Hits	1311	Target Neighborhood Hits	765	Shared Neighborhood Hits	617
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

STK23_MOUSE
NC score	0.554937 (rank : 823)	θ value	3.0926 (rank : 1147)
Query Neighborhood Hits	1311	Target Neighborhood Hits	572	Shared Neighborhood Hits	558
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_HUMAN
NC score	0.554426 (rank : 824)	θ value	0.279714 (rank : 935)
Query Neighborhood Hits	1311	Target Neighborhood Hits	556	Shared Neighborhood Hits	553
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

GUC2E_MOUSE
NC score	0.554047 (rank : 825)	θ value	0.0563607 (rank : 867)
Query Neighborhood Hits	1311	Target Neighborhood Hits	692	Shared Neighborhood Hits	642
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

ANPRA_HUMAN
NC score	0.543324 (rank : 826)	θ value	4.1701e-05 (rank : 792)
Query Neighborhood Hits	1311	Target Neighborhood Hits	612	Shared Neighborhood Hits	548
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
NC score	0.542403 (rank : 827)	θ value	1.87187e-05 (rank : 789)
Query Neighborhood Hits	1311	Target Neighborhood Hits	600	Shared Neighborhood Hits	540
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

TEX14_HUMAN
NC score	0.538936 (rank : 828)	θ value	0.0148317 (rank : 843)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1103	Shared Neighborhood Hits	697
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

ANPRB_MOUSE
NC score	0.538880 (rank : 829)	θ value	θ > 10 (rank : 1314)
Query Neighborhood Hits	1311	Target Neighborhood Hits	607	Shared Neighborhood Hits	559
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ILK1_HUMAN
NC score	0.533077 (rank : 830)	θ value	8.97725e-08 (rank : 755)
Query Neighborhood Hits	1311	Target Neighborhood Hits	857	Shared Neighborhood Hits	592
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.531571 (rank : 831)	θ value	8.97725e-08 (rank : 756)
Query Neighborhood Hits	1311	Target Neighborhood Hits	858	Shared Neighborhood Hits	593
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ILK2_HUMAN
NC score	0.516049 (rank : 832)	θ value	4.92598e-06 (rank : 778)
Query Neighborhood Hits	1311	Target Neighborhood Hits	848	Shared Neighborhood Hits	583
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

VRK2_MOUSE
NC score	0.513986 (rank : 833)	θ value	0.125558 (rank : 900)
Query Neighborhood Hits	1311	Target Neighborhood Hits	586	Shared Neighborhood Hits	574
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK2_HUMAN
NC score	0.508844 (rank : 834)	θ value	0.0431538 (rank : 864)
Query Neighborhood Hits	1311	Target Neighborhood Hits	582	Shared Neighborhood Hits	563
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_MOUSE
NC score	0.504960 (rank : 835)	θ value	0.0431538 (rank : 863)
Query Neighborhood Hits	1311	Target Neighborhood Hits	583	Shared Neighborhood Hits	575
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK1_HUMAN
NC score	0.501134 (rank : 836)	θ value	0.0563607 (rank : 873)
Query Neighborhood Hits	1311	Target Neighborhood Hits	584	Shared Neighborhood Hits	574
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

BUB1_HUMAN
NC score	0.423694 (rank : 837)	θ value	0.00228821 (rank : 822)
Query Neighborhood Hits	1311	Target Neighborhood Hits	543	Shared Neighborhood Hits	424
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

NTKL_MOUSE
NC score	0.414206 (rank : 838)	θ value	5.81887e-07 (rank : 768)
Query Neighborhood Hits	1311	Target Neighborhood Hits	326	Shared Neighborhood Hits	298
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

STK31_HUMAN
NC score	0.403036 (rank : 839)	θ value	0.00175202 (rank : 821)
Query Neighborhood Hits	1311	Target Neighborhood Hits	570	Shared Neighborhood Hits	423
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

PI3R4_MOUSE
NC score	0.373348 (rank : 840)	θ value	8.99809 (rank : 1294)
Query Neighborhood Hits	1311	Target Neighborhood Hits	535	Shared Neighborhood Hits	350
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PI3R4_HUMAN
NC score	0.359972 (rank : 841)	θ value	8.99809 (rank : 1293)
Query Neighborhood Hits	1311	Target Neighborhood Hits	534	Shared Neighborhood Hits	346
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

RN5A_MOUSE
NC score	0.354941 (rank : 842)	θ value	0.0961366 (rank : 884)
Query Neighborhood Hits	1311	Target Neighborhood Hits	899	Shared Neighborhood Hits	611
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

STK31_MOUSE
NC score	0.344321 (rank : 843)	θ value	0.00665767 (rank : 833)
Query Neighborhood Hits	1311	Target Neighborhood Hits	474	Shared Neighborhood Hits	357
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

K2002_HUMAN
NC score	0.343271 (rank : 844)	θ value	0.125558 (rank : 892)
Query Neighborhood Hits	1311	Target Neighborhood Hits	274	Shared Neighborhood Hits	261
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

NTKL_HUMAN
NC score	0.326842 (rank : 845)	θ value	1.43324e-05 (rank : 787)
Query Neighborhood Hits	1311	Target Neighborhood Hits	266	Shared Neighborhood Hits	228
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

K2002_MOUSE
NC score	0.285684 (rank : 846)	θ value	0.21417 (rank : 912)
Query Neighborhood Hits	1311	Target Neighborhood Hits	267	Shared Neighborhood Hits	236
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

VRK3_HUMAN
NC score	0.273375 (rank : 847)	θ value	θ > 10 (rank : 1499)
Query Neighborhood Hits	1311	Target Neighborhood Hits	349	Shared Neighborhood Hits	311
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VRK3_MOUSE
NC score	0.261253 (rank : 848)	θ value	θ > 10 (rank : 1500)
Query Neighborhood Hits	1311	Target Neighborhood Hits	342	Shared Neighborhood Hits	322
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

PXK_MOUSE
NC score	0.193437 (rank : 849)	θ value	5.27518 (rank : 1213)
Query Neighborhood Hits	1311	Target Neighborhood Hits	320	Shared Neighborhood Hits	215
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PRPK_MOUSE
NC score	0.157741 (rank : 850)	θ value	θ > 10 (rank : 1440)
Query Neighborhood Hits	1311	Target Neighborhood Hits	139	Shared Neighborhood Hits	131
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

RN5A_HUMAN
NC score	0.155360 (rank : 851)	θ value	θ > 10 (rank : 1454)
Query Neighborhood Hits	1311	Target Neighborhood Hits	608	Shared Neighborhood Hits	333
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

PRPK_HUMAN
NC score	0.154840 (rank : 852)	θ value	θ > 10 (rank : 1439)
Query Neighborhood Hits	1311	Target Neighborhood Hits	131	Shared Neighborhood Hits	129
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PXK_HUMAN
NC score	0.142842 (rank : 853)	θ value	θ > 10 (rank : 1446)
Query Neighborhood Hits	1311	Target Neighborhood Hits	216	Shared Neighborhood Hits	134
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

SLAP2_MOUSE
NC score	0.141265 (rank : 854)	θ value	θ > 10 (rank : 1482)
Query Neighborhood Hits	1311	Target Neighborhood Hits	136	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLAP2_HUMAN
NC score	0.137338 (rank : 855)	θ value	θ > 10 (rank : 1481)
Query Neighborhood Hits	1311	Target Neighborhood Hits	139	Shared Neighborhood Hits	46
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP1_HUMAN
NC score	0.135188 (rank : 856)	θ value	θ > 10 (rank : 1479)
Query Neighborhood Hits	1311	Target Neighborhood Hits	113	Shared Neighborhood Hits	41
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
NC score	0.133176 (rank : 857)	θ value	θ > 10 (rank : 1480)
Query Neighborhood Hits	1311	Target Neighborhood Hits	117	Shared Neighborhood Hits	41
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

GRAP_HUMAN
NC score	0.103832 (rank : 858)	θ value	θ > 10 (rank : 1374)
Query Neighborhood Hits	1311	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
NC score	0.103295 (rank : 859)	θ value	θ > 10 (rank : 1375)
Query Neighborhood Hits	1311	Target Neighborhood Hits	309	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

STAC3_MOUSE
NC score	0.101044 (rank : 860)	θ value	θ > 10 (rank : 1485)
Query Neighborhood Hits	1311	Target Neighborhood Hits	232	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_MOUSE
NC score	0.100627 (rank : 861)	θ value	θ > 10 (rank : 1487)
Query Neighborhood Hits	1311	Target Neighborhood Hits	268	Shared Neighborhood Hits	79
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRB2_HUMAN
NC score	0.100547 (rank : 862)	θ value	θ > 10 (rank : 1378)
Query Neighborhood Hits	1311	Target Neighborhood Hits	310	Shared Neighborhood Hits	59
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.100495 (rank : 863)	θ value	θ > 10 (rank : 1379)
Query Neighborhood Hits	1311	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

STAC3_HUMAN
NC score	0.100438 (rank : 864)	θ value	θ > 10 (rank : 1484)
Query Neighborhood Hits	1311	Target Neighborhood Hits	228	Shared Neighborhood Hits	72
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GRAP2_HUMAN
NC score	0.100128 (rank : 865)	θ value	θ > 10 (rank : 1372)
Query Neighborhood Hits	1311	Target Neighborhood Hits	304	Shared Neighborhood Hits	59
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRP3_HUMAN
NC score	0.100002 (rank : 866)	θ value	θ > 10 (rank : 1381)
Query Neighborhood Hits	1311	Target Neighborhood Hits	131	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

BUB1B_HUMAN
NC score	0.099100 (rank : 867)	θ value	θ > 10 (rank : 1318)
Query Neighborhood Hits	1311	Target Neighborhood Hits	208	Shared Neighborhood Hits	135
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

GRAP2_MOUSE
NC score	0.098511 (rank : 868)	θ value	θ > 10 (rank : 1373)
Query Neighborhood Hits	1311	Target Neighborhood Hits	297	Shared Neighborhood Hits	58
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCK2_HUMAN
NC score	0.095893 (rank : 869)	θ value	θ > 10 (rank : 1410)
Query Neighborhood Hits	1311	Target Neighborhood Hits	310	Shared Neighborhood Hits	61
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.095736 (rank : 870)	θ value	θ > 10 (rank : 1409)
Query Neighborhood Hits	1311	Target Neighborhood Hits	312	Shared Neighborhood Hits	59
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SH21B_MOUSE
NC score	0.094533 (rank : 871)	θ value	θ > 10 (rank : 1470)
Query Neighborhood Hits	1311	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

STAC_HUMAN
NC score	0.093801 (rank : 872)	θ value	θ > 10 (rank : 1486)
Query Neighborhood Hits	1311	Target Neighborhood Hits	276	Shared Neighborhood Hits	80
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

VAV3_HUMAN
NC score	0.088841 (rank : 873)	θ value	θ > 10 (rank : 1495)
Query Neighborhood Hits	1311	Target Neighborhood Hits	398	Shared Neighborhood Hits	96
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.088818 (rank : 874)	θ value	θ > 10 (rank : 1496)
Query Neighborhood Hits	1311	Target Neighborhood Hits	404	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
NC score	0.086777 (rank : 875)	θ value	θ > 10 (rank : 1497)
Query Neighborhood Hits	1311	Target Neighborhood Hits	452	Shared Neighborhood Hits	109
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_HUMAN
NC score	0.085448 (rank : 876)	θ value	θ > 10 (rank : 1493)
Query Neighborhood Hits	1311	Target Neighborhood Hits	453	Shared Neighborhood Hits	102
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

SH21A_MOUSE
NC score	0.084681 (rank : 877)	θ value	θ > 10 (rank : 1468)
Query Neighborhood Hits	1311	Target Neighborhood Hits	89	Shared Neighborhood Hits	38
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
NC score	0.084680 (rank : 878)	θ value	θ > 10 (rank : 1469)
Query Neighborhood Hits	1311	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

PACE1_MOUSE
NC score	0.084292 (rank : 879)	θ value	θ > 10 (rank : 1426)
Query Neighborhood Hits	1311	Target Neighborhood Hits	92	Shared Neighborhood Hits	61
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

BUB1B_MOUSE
NC score	0.082653 (rank : 880)	θ value	θ > 10 (rank : 1319)
Query Neighborhood Hits	1311	Target Neighborhood Hits	202	Shared Neighborhood Hits	123
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

VAV2_MOUSE
NC score	0.081901 (rank : 881)	θ value	θ > 10 (rank : 1494)
Query Neighborhood Hits	1311	Target Neighborhood Hits	456	Shared Neighborhood Hits	97
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

RASA1_HUMAN
NC score	0.081595 (rank : 882)	θ value	θ > 10 (rank : 1448)
Query Neighborhood Hits	1311	Target Neighborhood Hits	258	Shared Neighborhood Hits	61
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PACE1_HUMAN
NC score	0.081125 (rank : 883)	θ value	θ > 10 (rank : 1425)
Query Neighborhood Hits	1311	Target Neighborhood Hits	74	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

SH24A_HUMAN
NC score	0.081076 (rank : 884)	θ value	θ > 10 (rank : 1471)
Query Neighborhood Hits	1311	Target Neighborhood Hits	455	Shared Neighborhood Hits	192
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

VAV_MOUSE
NC score	0.080642 (rank : 885)	θ value	θ > 10 (rank : 1498)
Query Neighborhood Hits	1311	Target Neighborhood Hits	430	Shared Neighborhood Hits	99
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CHIO_HUMAN
NC score	0.080136 (rank : 886)	θ value	θ > 10 (rank : 1335)
Query Neighborhood Hits	1311	Target Neighborhood Hits	220	Shared Neighborhood Hits	63
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

DGKD_HUMAN
NC score	0.080108 (rank : 887)	θ value	θ > 10 (rank : 1356)
Query Neighborhood Hits	1311	Target Neighborhood Hits	231	Shared Neighborhood Hits	82
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

CHIN_MOUSE
NC score	0.079642 (rank : 888)	θ value	θ > 10 (rank : 1334)
Query Neighborhood Hits	1311	Target Neighborhood Hits	229	Shared Neighborhood Hits	66
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

PDZD8_HUMAN
NC score	0.078900 (rank : 889)	θ value	θ > 10 (rank : 1429)
Query Neighborhood Hits	1311	Target Neighborhood Hits	185	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

CHIN_HUMAN
NC score	0.078810 (rank : 890)	θ value	θ > 10 (rank : 1333)
Query Neighborhood Hits	1311	Target Neighborhood Hits	227	Shared Neighborhood Hits	64
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

SH21A_HUMAN
NC score	0.078426 (rank : 891)	θ value	θ > 10 (rank : 1467)
Query Neighborhood Hits	1311	Target Neighborhood Hits	89	Shared Neighborhood Hits	37
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

RASF1_MOUSE
NC score	0.078054 (rank : 892)	θ value	θ > 10 (rank : 1450)
Query Neighborhood Hits	1311	Target Neighborhood Hits	74	Shared Neighborhood Hits	33
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

P85B_MOUSE
NC score	0.076975 (rank : 893)	θ value	θ > 10 (rank : 1424)
Query Neighborhood Hits	1311	Target Neighborhood Hits	519	Shared Neighborhood Hits	179
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ITSN1_MOUSE
NC score	0.076375 (rank : 894)	θ value	0.163984 (rank : 904)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1669	Shared Neighborhood Hits	367
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

P85B_HUMAN
NC score	0.075667 (rank : 895)	θ value	θ > 10 (rank : 1423)
Query Neighborhood Hits	1311	Target Neighborhood Hits	543	Shared Neighborhood Hits	188
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CCD11_HUMAN
NC score	0.075065 (rank : 896)	θ value	0.813845 (rank : 989)
Query Neighborhood Hits	1311	Target Neighborhood Hits	822	Shared Neighborhood Hits	251
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

UN13A_HUMAN
NC score	0.074696 (rank : 897)	θ value	θ > 10 (rank : 1490)
Query Neighborhood Hits	1311	Target Neighborhood Hits	285	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

ITSN1_HUMAN
NC score	0.074577 (rank : 898)	θ value	0.279714 (rank : 927)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1757	Shared Neighborhood Hits	369
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

DGKH_HUMAN
NC score	0.073086 (rank : 899)	θ value	θ > 10 (rank : 1358)
Query Neighborhood Hits	1311	Target Neighborhood Hits	255	Shared Neighborhood Hits	71
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

UN13B_HUMAN
NC score	0.072192 (rank : 900)	θ value	θ > 10 (rank : 1491)
Query Neighborhood Hits	1311	Target Neighborhood Hits	217	Shared Neighborhood Hits	53
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

P55G_HUMAN
NC score	0.072108 (rank : 901)	θ value	θ > 10 (rank : 1419)
Query Neighborhood Hits	1311	Target Neighborhood Hits	451	Shared Neighborhood Hits	155
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

INCE_MOUSE
NC score	0.072100 (rank : 902)	θ value	1.43324e-05 (rank : 786)
Query Neighborhood Hits	1311	Target Neighborhood Hits	903	Shared Neighborhood Hits	219
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

DAPP1_HUMAN
NC score	0.071998 (rank : 903)	θ value	θ > 10 (rank : 1349)
Query Neighborhood Hits	1311	Target Neighborhood Hits	227	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

P55G_MOUSE
NC score	0.071823 (rank : 904)	θ value	θ > 10 (rank : 1420)
Query Neighborhood Hits	1311	Target Neighborhood Hits	401	Shared Neighborhood Hits	133
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

DAPP1_MOUSE
NC score	0.070023 (rank : 905)	θ value	θ > 10 (rank : 1350)
Query Neighborhood Hits	1311	Target Neighborhood Hits	225	Shared Neighborhood Hits	54
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

UN13B_MOUSE
NC score	0.069316 (rank : 906)	θ value	θ > 10 (rank : 1492)
Query Neighborhood Hits	1311	Target Neighborhood Hits	210	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

INCE_HUMAN
NC score	0.069255 (rank : 907)	θ value	0.000158464 (rank : 803)
Query Neighborhood Hits	1311	Target Neighborhood Hits	978	Shared Neighborhood Hits	222
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

NEO1_MOUSE
NC score	0.069127 (rank : 908)	θ value	θ > 10 (rank : 1413)
Query Neighborhood Hits	1311	Target Neighborhood Hits	523	Shared Neighborhood Hits	105
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NEO1_HUMAN
NC score	0.069042 (rank : 909)	θ value	θ > 10 (rank : 1412)
Query Neighborhood Hits	1311	Target Neighborhood Hits	530	Shared Neighborhood Hits	102
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

TRHY_HUMAN
NC score	0.068874 (rank : 910)	θ value	9.29e-05 (rank : 797)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1385	Shared Neighborhood Hits	267
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

DGKQ_HUMAN
NC score	0.068812 (rank : 911)	θ value	θ > 10 (rank : 1359)
Query Neighborhood Hits	1311	Target Neighborhood Hits	131	Shared Neighborhood Hits	39
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

CA065_HUMAN
NC score	0.068382 (rank : 912)	θ value	θ > 10 (rank : 1320)
Query Neighborhood Hits	1311	Target Neighborhood Hits	469	Shared Neighborhood Hits	173
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

FGRL1_MOUSE
NC score	0.068357 (rank : 913)	θ value	θ > 10 (rank : 1363)
Query Neighborhood Hits	1311	Target Neighborhood Hits	325	Shared Neighborhood Hits	49
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

CRKL_MOUSE
NC score	0.068188 (rank : 914)	θ value	θ > 10 (rank : 1346)
Query Neighborhood Hits	1311	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ITSN2_MOUSE
NC score	0.067585 (rank : 915)	θ value	θ > 10 (rank : 1387)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1371	Shared Neighborhood Hits	310
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CHIO_MOUSE
NC score	0.067442 (rank : 916)	θ value	θ > 10 (rank : 1336)
Query Neighborhood Hits	1311	Target Neighborhood Hits	130	Shared Neighborhood Hits	38
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CRKL_HUMAN
NC score	0.067347 (rank : 917)	θ value	θ > 10 (rank : 1345)
Query Neighborhood Hits	1311	Target Neighborhood Hits	313	Shared Neighborhood Hits	59
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

INVO_MOUSE
NC score	0.066893 (rank : 918)	θ value	θ > 10 (rank : 1385)
Query Neighborhood Hits	1311	Target Neighborhood Hits	474	Shared Neighborhood Hits	146
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

FGRL1_HUMAN
NC score	0.066728 (rank : 919)	θ value	θ > 10 (rank : 1362)
Query Neighborhood Hits	1311	Target Neighborhood Hits	335	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

PININ_HUMAN
NC score	0.066323 (rank : 920)	θ value	1.06291 (rank : 1021)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	240
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

ZC313_HUMAN
NC score	0.066018 (rank : 921)	θ value	θ > 10 (rank : 1501)
Query Neighborhood Hits	1311	Target Neighborhood Hits	772	Shared Neighborhood Hits	248
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

MAP1A_HUMAN
NC score	0.065934 (rank : 922)	θ value	0.21417 (rank : 913)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1626	Shared Neighborhood Hits	362
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

ITSN2_HUMAN
NC score	0.065757 (rank : 923)	θ value	θ > 10 (rank : 1386)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1173	Shared Neighborhood Hits	249
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

CALD1_HUMAN
NC score	0.065463 (rank : 924)	θ value	0.0563607 (rank : 866)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	240
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

TCRG1_MOUSE
NC score	0.065131 (rank : 925)	θ value	0.0193708 (rank : 847)
Query Neighborhood Hits	1311	Target Neighborhood Hits	947	Shared Neighborhood Hits	252
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

MYOM1_MOUSE
NC score	0.064998 (rank : 926)	θ value	θ > 10 (rank : 1397)
Query Neighborhood Hits	1311	Target Neighborhood Hits	415	Shared Neighborhood Hits	94
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

MYOM1_HUMAN
NC score	0.064895 (rank : 927)	θ value	θ > 10 (rank : 1396)
Query Neighborhood Hits	1311	Target Neighborhood Hits	405	Shared Neighborhood Hits	100
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

RIMB1_MOUSE
NC score	0.064838 (rank : 928)	θ value	0.279714 (rank : 933)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1376	Shared Neighborhood Hits	311
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

MY18A_HUMAN
NC score	0.064555 (rank : 929)	θ value	0.00134147 (rank : 817)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1929	Shared Neighborhood Hits	407
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RASF1_HUMAN
NC score	0.064340 (rank : 930)	θ value	θ > 10 (rank : 1449)
Query Neighborhood Hits	1311	Target Neighborhood Hits	62	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

HSH2D_HUMAN
NC score	0.064248 (rank : 931)	θ value	θ > 10 (rank : 1383)
Query Neighborhood Hits	1311	Target Neighborhood Hits	159	Shared Neighborhood Hits	43
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

MY18A_MOUSE
NC score	0.064050 (rank : 932)	θ value	0.00665767 (rank : 832)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1989	Shared Neighborhood Hits	416
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

TCRG1_HUMAN
NC score	0.064024 (rank : 933)	θ value	0.0193708 (rank : 846)
Query Neighborhood Hits	1311	Target Neighborhood Hits	929	Shared Neighborhood Hits	252
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

DCC_MOUSE
NC score	0.063807 (rank : 934)	θ value	θ > 10 (rank : 1352)
Query Neighborhood Hits	1311	Target Neighborhood Hits	896	Shared Neighborhood Hits	134
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

SHE_HUMAN
NC score	0.063592 (rank : 935)	θ value	θ > 10 (rank : 1477)
Query Neighborhood Hits	1311	Target Neighborhood Hits	164	Shared Neighborhood Hits	49
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SWP70_MOUSE
NC score	0.063320 (rank : 936)	θ value	θ > 10 (rank : 1488)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1097	Shared Neighborhood Hits	272
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SHE_MOUSE
NC score	0.063306 (rank : 937)	θ value	θ > 10 (rank : 1478)
Query Neighborhood Hits	1311	Target Neighborhood Hits	169	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

CCD46_MOUSE
NC score	0.063220 (rank : 938)	θ value	2.36792 (rank : 1082)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1405	Shared Neighborhood Hits	314
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

IF3A_MOUSE
NC score	0.063171 (rank : 939)	θ value	0.0563607 (rank : 868)
Query Neighborhood Hits	1311	Target Neighborhood Hits	871	Shared Neighborhood Hits	238
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

PLCG1_MOUSE
NC score	0.063146 (rank : 940)	θ value	θ > 10 (rank : 1437)
Query Neighborhood Hits	1311	Target Neighborhood Hits	314	Shared Neighborhood Hits	72
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CCD19_HUMAN
NC score	0.063007 (rank : 941)	θ value	θ > 10 (rank : 1322)
Query Neighborhood Hits	1311	Target Neighborhood Hits	639	Shared Neighborhood Hits	191
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

DCC_HUMAN
NC score	0.062989 (rank : 942)	θ value	θ > 10 (rank : 1351)
Query Neighborhood Hits	1311	Target Neighborhood Hits	583	Shared Neighborhood Hits	96
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

CCD46_HUMAN
NC score	0.062502 (rank : 943)	θ value	5.27518 (rank : 1190)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1430	Shared Neighborhood Hits	314
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

IF3A_HUMAN
NC score	0.062436 (rank : 944)	θ value	0.125558 (rank : 891)
Query Neighborhood Hits	1311	Target Neighborhood Hits	875	Shared Neighborhood Hits	238
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

PLCG1_HUMAN
NC score	0.062378 (rank : 945)	θ value	θ > 10 (rank : 1436)
Query Neighborhood Hits	1311	Target Neighborhood Hits	293	Shared Neighborhood Hits	67
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

DSCL1_HUMAN
NC score	0.062135 (rank : 946)	θ value	θ > 10 (rank : 1361)
Query Neighborhood Hits	1311	Target Neighborhood Hits	589	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

CCD11_MOUSE
NC score	0.062031 (rank : 947)	θ value	θ > 10 (rank : 1321)
Query Neighborhood Hits	1311	Target Neighborhood Hits	498	Shared Neighborhood Hits	148
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD45_MOUSE
NC score	0.061987 (rank : 948)	θ value	θ > 10 (rank : 1327)
Query Neighborhood Hits	1311	Target Neighborhood Hits	663	Shared Neighborhood Hits	206
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

PININ_MOUSE
NC score	0.061965 (rank : 949)	θ value	θ > 10 (rank : 1435)
Query Neighborhood Hits	1311	Target Neighborhood Hits	777	Shared Neighborhood Hits	241
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

CCD21_MOUSE
NC score	0.061877 (rank : 950)	θ value	θ > 10 (rank : 1324)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1135	Shared Neighborhood Hits	302
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

INVO_HUMAN
NC score	0.061861 (rank : 951)	θ value	θ > 10 (rank : 1384)
Query Neighborhood Hits	1311	Target Neighborhood Hits	636	Shared Neighborhood Hits	187
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

GRB14_MOUSE
NC score	0.061847 (rank : 952)	θ value	θ > 10 (rank : 1377)
Query Neighborhood Hits	1311	Target Neighborhood Hits	149	Shared Neighborhood Hits	44
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SDK1_HUMAN
NC score	0.061689 (rank : 953)	θ value	θ > 10 (rank : 1463)
Query Neighborhood Hits	1311	Target Neighborhood Hits	511	Shared Neighborhood Hits	93
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

RBM25_HUMAN
NC score	0.061677 (rank : 954)	θ value	4.03905 (rank : 1174)
Query Neighborhood Hits	1311	Target Neighborhood Hits	682	Shared Neighborhood Hits	178
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

CCD91_HUMAN
NC score	0.061496 (rank : 955)	θ value	6.88961 (rank : 1231)
Query Neighborhood Hits	1311	Target Neighborhood Hits	868	Shared Neighborhood Hits	274
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CNTRB_MOUSE
NC score	0.061287 (rank : 956)	θ value	θ > 10 (rank : 1343)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1029	Shared Neighborhood Hits	257
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

RIMB1_HUMAN
NC score	0.061021 (rank : 957)	θ value	0.125558 (rank : 896)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1479	Shared Neighborhood Hits	306
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

PLCG2_HUMAN
NC score	0.060941 (rank : 958)	θ value	θ > 10 (rank : 1438)
Query Neighborhood Hits	1311	Target Neighborhood Hits	280	Shared Neighborhood Hits	59
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

MYOM2_HUMAN
NC score	0.060366 (rank : 959)	θ value	θ > 10 (rank : 1398)
Query Neighborhood Hits	1311	Target Neighborhood Hits	341	Shared Neighborhood Hits	79
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

AZI1_HUMAN
NC score	0.060273 (rank : 960)	θ value	2.36792 (rank : 1079)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1000	Shared Neighborhood Hits	237
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

DSCAM_HUMAN
NC score	0.060195 (rank : 961)	θ value	θ > 10 (rank : 1360)
Query Neighborhood Hits	1311	Target Neighborhood Hits	524	Shared Neighborhood Hits	86
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

DCX_HUMAN
NC score	0.060120 (rank : 962)	θ value	θ > 10 (rank : 1353)
Query Neighborhood Hits	1311	Target Neighborhood Hits	141	Shared Neighborhood Hits	33
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

SDK1_MOUSE
NC score	0.060089 (rank : 963)	θ value	θ > 10 (rank : 1464)
Query Neighborhood Hits	1311	Target Neighborhood Hits	495	Shared Neighborhood Hits	97
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

K0555_HUMAN
NC score	0.060086 (rank : 964)	θ value	θ > 10 (rank : 1388)
Query Neighborhood Hits	1311	Target Neighborhood Hits	880	Shared Neighborhood Hits	236
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

MYPC3_MOUSE
NC score	0.060034 (rank : 965)	θ value	θ > 10 (rank : 1402)
Query Neighborhood Hits	1311	Target Neighborhood Hits	310	Shared Neighborhood Hits	71
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

RGNEF_MOUSE
NC score	0.059947 (rank : 966)	θ value	θ > 10 (rank : 1452)
Query Neighborhood Hits	1311	Target Neighborhood Hits	641	Shared Neighborhood Hits	227
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

CI039_HUMAN
NC score	0.059848 (rank : 967)	θ value	θ > 10 (rank : 1337)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1171	Shared Neighborhood Hits	281
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

CIP4_HUMAN
NC score	0.059725 (rank : 968)	θ value	θ > 10 (rank : 1339)
Query Neighborhood Hits	1311	Target Neighborhood Hits	374	Shared Neighborhood Hits	120
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

NCAM2_MOUSE
NC score	0.059723 (rank : 969)	θ value	θ > 10 (rank : 1408)
Query Neighborhood Hits	1311	Target Neighborhood Hits	472	Shared Neighborhood Hits	82
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

XE7_HUMAN
NC score	0.059713 (rank : 970)	θ value	1.06291 (rank : 1027)
Query Neighborhood Hits	1311	Target Neighborhood Hits	738	Shared Neighborhood Hits	196
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

SWP70_HUMAN
NC score	0.059664 (rank : 971)	θ value	8.99809 (rank : 1306)
Query Neighborhood Hits	1311	Target Neighborhood Hits	973	Shared Neighborhood Hits	241
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SDK2_HUMAN
NC score	0.059653 (rank : 972)	θ value	θ > 10 (rank : 1465)
Query Neighborhood Hits	1311	Target Neighborhood Hits	495	Shared Neighborhood Hits	97
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CCD41_MOUSE
NC score	0.059451 (rank : 973)	θ value	0.0431538 (rank : 855)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1399	Shared Neighborhood Hits	326
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

PIBF1_HUMAN
NC score	0.059360 (rank : 974)	θ value	θ > 10 (rank : 1434)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1041	Shared Neighborhood Hits	273
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

SMC1A_MOUSE
NC score	0.059333 (rank : 975)	θ value	1.87187e-05 (rank : 790)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1384	Shared Neighborhood Hits	303
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

REN3B_HUMAN
NC score	0.059269 (rank : 976)	θ value	0.163984 (rank : 908)
Query Neighborhood Hits	1311	Target Neighborhood Hits	412	Shared Neighborhood Hits	149
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

GAS8_MOUSE
NC score	0.058828 (rank : 977)	θ value	θ > 10 (rank : 1365)
Query Neighborhood Hits	1311	Target Neighborhood Hits	622	Shared Neighborhood Hits	194
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

L1CAM_HUMAN
NC score	0.058758 (rank : 978)	θ value	θ > 10 (rank : 1390)
Query Neighborhood Hits	1311	Target Neighborhood Hits	457	Shared Neighborhood Hits	91
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

CRK_HUMAN
NC score	0.058742 (rank : 979)	θ value	θ > 10 (rank : 1347)
Query Neighborhood Hits	1311	Target Neighborhood Hits	308	Shared Neighborhood Hits	58
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

NEMO_HUMAN
NC score	0.058345 (rank : 980)	θ value	θ > 10 (rank : 1411)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	231
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

SDK2_MOUSE
NC score	0.058285 (rank : 981)	θ value	θ > 10 (rank : 1466)
Query Neighborhood Hits	1311	Target Neighborhood Hits	480	Shared Neighborhood Hits	97
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

ROBO1_MOUSE
NC score	0.058203 (rank : 982)	θ value	θ > 10 (rank : 1456)
Query Neighborhood Hits	1311	Target Neighborhood Hits	559	Shared Neighborhood Hits	94
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

NCAM2_HUMAN
NC score	0.058188 (rank : 983)	θ value	θ > 10 (rank : 1407)
Query Neighborhood Hits	1311	Target Neighborhood Hits	441	Shared Neighborhood Hits	80
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

NEST_HUMAN
NC score	0.057976 (rank : 984)	θ value	2.36792 (rank : 1098)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1305	Shared Neighborhood Hits	321
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

P85A_HUMAN
NC score	0.057950 (rank : 985)	θ value	θ > 10 (rank : 1421)
Query Neighborhood Hits	1311	Target Neighborhood Hits	479	Shared Neighborhood Hits	143
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CN145_HUMAN
NC score	0.057914 (rank : 986)	θ value	0.47712 (rank : 957)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1196	Shared Neighborhood Hits	282
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

NFASC_HUMAN
NC score	0.057873 (rank : 987)	θ value	8.99809 (rank : 1289)
Query Neighborhood Hits	1311	Target Neighborhood Hits	497	Shared Neighborhood Hits	101
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

ROBO1_HUMAN
NC score	0.057865 (rank : 988)	θ value	θ > 10 (rank : 1455)
Query Neighborhood Hits	1311	Target Neighborhood Hits	529	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

CCD45_HUMAN
NC score	0.057820 (rank : 989)	θ value	θ > 10 (rank : 1326)
Query Neighborhood Hits	1311	Target Neighborhood Hits	525	Shared Neighborhood Hits	198
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

IF2P_HUMAN
NC score	0.057792 (rank : 990)	θ value	7.1131e-05 (rank : 796)
Query Neighborhood Hits	1311	Target Neighborhood Hits	889	Shared Neighborhood Hits	199
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

GRAP1_MOUSE
NC score	0.057567 (rank : 991)	θ value	θ > 10 (rank : 1371)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1234	Shared Neighborhood Hits	288
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

GOGA4_HUMAN
NC score	0.057487 (rank : 992)	θ value	0.47712 (rank : 961)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2034	Shared Neighborhood Hits	376
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

NRCAM_HUMAN
NC score	0.057482 (rank : 993)	θ value	θ > 10 (rank : 1416)
Query Neighborhood Hits	1311	Target Neighborhood Hits	439	Shared Neighborhood Hits	93
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

CING_MOUSE
NC score	0.057389 (rank : 994)	θ value	8.99809 (rank : 1265)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1432	Shared Neighborhood Hits	315
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

IFT81_HUMAN
NC score	0.057359 (rank : 995)	θ value	2.36792 (rank : 1092)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	231
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

CRK_MOUSE
NC score	0.057329 (rank : 996)	θ value	θ > 10 (rank : 1348)
Query Neighborhood Hits	1311	Target Neighborhood Hits	314	Shared Neighborhood Hits	58
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

GAS8_HUMAN
NC score	0.057289 (rank : 997)	θ value	θ > 10 (rank : 1364)
Query Neighborhood Hits	1311	Target Neighborhood Hits	819	Shared Neighborhood Hits	230
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

DCX_MOUSE
NC score	0.057229 (rank : 998)	θ value	θ > 10 (rank : 1354)
Query Neighborhood Hits	1311	Target Neighborhood Hits	124	Shared Neighborhood Hits	26
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

ENAH_HUMAN
NC score	0.057180 (rank : 999)	θ value	0.0431538 (rank : 856)
Query Neighborhood Hits	1311	Target Neighborhood Hits	784	Shared Neighborhood Hits	199
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

ROBO2_MOUSE
NC score	0.057079 (rank : 1000)	θ value	θ > 10 (rank : 1458)
Query Neighborhood Hits	1311	Target Neighborhood Hits	504	Shared Neighborhood Hits	85
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

CCD96_MOUSE
NC score	0.057041 (rank : 1001)	θ value	2.36792 (rank : 1083)
Query Neighborhood Hits	1311	Target Neighborhood Hits	704	Shared Neighborhood Hits	225
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

GOGA4_MOUSE
NC score	0.057009 (rank : 1002)	θ value	0.163984 (rank : 903)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1939	Shared Neighborhood Hits	380
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

PLCB4_HUMAN
NC score	0.056969 (rank : 1003)	θ value	8.99809 (rank : 1296)
Query Neighborhood Hits	1311	Target Neighborhood Hits	658	Shared Neighborhood Hits	221
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

MYPC3_HUMAN
NC score	0.056962 (rank : 1004)	θ value	θ > 10 (rank : 1401)
Query Neighborhood Hits	1311	Target Neighborhood Hits	318	Shared Neighborhood Hits	74
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

CP250_HUMAN
NC score	0.056930 (rank : 1005)	θ value	θ > 10 (rank : 1344)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1805	Shared Neighborhood Hits	353
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

ROBO2_HUMAN
NC score	0.056820 (rank : 1006)	θ value	θ > 10 (rank : 1457)
Query Neighborhood Hits	1311	Target Neighborhood Hits	479	Shared Neighborhood Hits	79
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

RPGR_MOUSE
NC score	0.056609 (rank : 1007)	θ value	0.279714 (rank : 934)
Query Neighborhood Hits	1311	Target Neighborhood Hits	281	Shared Neighborhood Hits	129
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

IFT81_MOUSE
NC score	0.056551 (rank : 1008)	θ value	0.47712 (rank : 963)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	241
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

GRB14_HUMAN
NC score	0.056463 (rank : 1009)	θ value	θ > 10 (rank : 1376)
Query Neighborhood Hits	1311	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

RB6I2_HUMAN
NC score	0.056394 (rank : 1010)	θ value	0.0330416 (rank : 853)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1584	Shared Neighborhood Hits	328
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

TPR_HUMAN
NC score	0.056294 (rank : 1011)	θ value	0.000121331 (rank : 800)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1921	Shared Neighborhood Hits	381
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

ZN291_HUMAN
NC score	0.056266 (rank : 1012)	θ value	0.0961366 (rank : 886)
Query Neighborhood Hits	1311	Target Neighborhood Hits	647	Shared Neighborhood Hits	171
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

MYPN_HUMAN
NC score	0.056223 (rank : 1013)	θ value	θ > 10 (rank : 1403)
Query Neighborhood Hits	1311	Target Neighborhood Hits	418	Shared Neighborhood Hits	71
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

SDCG8_HUMAN
NC score	0.056194 (rank : 1014)	θ value	θ > 10 (rank : 1461)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1002	Shared Neighborhood Hits	281
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

MYPN_MOUSE
NC score	0.056071 (rank : 1015)	θ value	θ > 10 (rank : 1404)
Query Neighborhood Hits	1311	Target Neighborhood Hits	421	Shared Neighborhood Hits	65
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

GOGA1_HUMAN
NC score	0.056032 (rank : 1016)	θ value	0.00390308 (rank : 825)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1222	Shared Neighborhood Hits	273
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

CF060_HUMAN
NC score	0.056024 (rank : 1017)	θ value	θ > 10 (rank : 1331)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1270	Shared Neighborhood Hits	301
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

L1CAM_MOUSE
NC score	0.055951 (rank : 1018)	θ value	θ > 10 (rank : 1391)
Query Neighborhood Hits	1311	Target Neighborhood Hits	457	Shared Neighborhood Hits	92
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

PCNT_HUMAN
NC score	0.055818 (rank : 1019)	θ value	θ > 10 (rank : 1427)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1551	Shared Neighborhood Hits	327
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

MYOTI_HUMAN
NC score	0.055816 (rank : 1020)	θ value	θ > 10 (rank : 1399)
Query Neighborhood Hits	1311	Target Neighborhood Hits	292	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

ACINU_HUMAN
NC score	0.055732 (rank : 1021)	θ value	θ > 10 (rank : 1312)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	254
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

PEPL_MOUSE
NC score	0.055663 (rank : 1022)	θ value	0.163984 (rank : 907)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1105	Shared Neighborhood Hits	286
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

ROBO3_HUMAN
NC score	0.055600 (rank : 1023)	θ value	θ > 10 (rank : 1459)
Query Neighborhood Hits	1311	Target Neighborhood Hits	570	Shared Neighborhood Hits	92
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

NRCAM_MOUSE
NC score	0.055520 (rank : 1024)	θ value	θ > 10 (rank : 1417)
Query Neighborhood Hits	1311	Target Neighborhood Hits	432	Shared Neighborhood Hits	93
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

P85A_MOUSE
NC score	0.055496 (rank : 1025)	θ value	θ > 10 (rank : 1422)
Query Neighborhood Hits	1311	Target Neighborhood Hits	435	Shared Neighborhood Hits	128
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PCNT_MOUSE
NC score	0.055269 (rank : 1026)	θ value	θ > 10 (rank : 1428)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1207	Shared Neighborhood Hits	271
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

SMC1A_HUMAN
NC score	0.055248 (rank : 1027)	θ value	0.62314 (rank : 978)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1346	Shared Neighborhood Hits	297
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

MD1L1_HUMAN
NC score	0.055150 (rank : 1028)	θ value	θ > 10 (rank : 1395)
Query Neighborhood Hits	1311	Target Neighborhood Hits	893	Shared Neighborhood Hits	241
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

CING_HUMAN
NC score	0.055101 (rank : 1029)	θ value	0.813845 (rank : 991)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1275	Shared Neighborhood Hits	300
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

APS_HUMAN
NC score	0.055087 (rank : 1030)	θ value	θ > 10 (rank : 1315)
Query Neighborhood Hits	1311	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

NPHP1_HUMAN
NC score	0.055063 (rank : 1031)	θ value	θ > 10 (rank : 1414)
Query Neighborhood Hits	1311	Target Neighborhood Hits	288	Shared Neighborhood Hits	81
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PGFRL_HUMAN
NC score	0.054795 (rank : 1032)	θ value	θ > 10 (rank : 1430)
Query Neighborhood Hits	1311	Target Neighborhood Hits	115	Shared Neighborhood Hits	28
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

GOGB1_HUMAN
NC score	0.054779 (rank : 1033)	θ value	0.47712 (rank : 962)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2297	Shared Neighborhood Hits	407
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

CCD41_HUMAN
NC score	0.054733 (rank : 1034)	θ value	θ > 10 (rank : 1325)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1139	Shared Neighborhood Hits	272
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CI093_HUMAN
NC score	0.054610 (rank : 1035)	θ value	θ > 10 (rank : 1338)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1088	Shared Neighborhood Hits	273
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

SDCG8_MOUSE
NC score	0.054370 (rank : 1036)	θ value	θ > 10 (rank : 1462)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	260
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

NPHP1_MOUSE
NC score	0.054289 (rank : 1037)	θ value	θ > 10 (rank : 1415)
Query Neighborhood Hits	1311	Target Neighborhood Hits	267	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PEPL_HUMAN
NC score	0.054224 (rank : 1038)	θ value	0.62314 (rank : 977)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1141	Shared Neighborhood Hits	290
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

OBSL1_HUMAN
NC score	0.054218 (rank : 1039)	θ value	θ > 10 (rank : 1418)
Query Neighborhood Hits	1311	Target Neighborhood Hits	354	Shared Neighborhood Hits	54
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

MD1L1_MOUSE
NC score	0.054203 (rank : 1040)	θ value	5.27518 (rank : 1207)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1001	Shared Neighborhood Hits	245
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

DESP_HUMAN
NC score	0.054178 (rank : 1041)	θ value	0.125558 (rank : 889)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1470	Shared Neighborhood Hits	320
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

RB6I2_MOUSE
NC score	0.054164 (rank : 1042)	θ value	0.0961366 (rank : 883)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1433	Shared Neighborhood Hits	299
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

DGKB_HUMAN
NC score	0.054020 (rank : 1043)	θ value	θ > 10 (rank : 1355)
Query Neighborhood Hits	1311	Target Neighborhood Hits	238	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

LRC45_MOUSE
NC score	0.053984 (rank : 1044)	θ value	θ > 10 (rank : 1393)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	244
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

PGFRL_MOUSE
NC score	0.053971 (rank : 1045)	θ value	θ > 10 (rank : 1431)
Query Neighborhood Hits	1311	Target Neighborhood Hits	106	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

NFASC_MOUSE
NC score	0.053539 (rank : 1046)	θ value	8.99809 (rank : 1290)
Query Neighborhood Hits	1311	Target Neighborhood Hits	475	Shared Neighborhood Hits	100
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

SM1L2_HUMAN
NC score	0.053458 (rank : 1047)	θ value	6.88961 (rank : 1252)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1019	Shared Neighborhood Hits	267
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

MYOTI_MOUSE
NC score	0.053317 (rank : 1048)	θ value	θ > 10 (rank : 1400)
Query Neighborhood Hits	1311	Target Neighborhood Hits	297	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

CNTN5_HUMAN
NC score	0.053184 (rank : 1049)	θ value	θ > 10 (rank : 1342)
Query Neighborhood Hits	1311	Target Neighborhood Hits	446	Shared Neighborhood Hits	86
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CF182_MOUSE
NC score	0.053170 (rank : 1050)	θ value	θ > 10 (rank : 1332)
Query Neighborhood Hits	1311	Target Neighborhood Hits	551	Shared Neighborhood Hits	174
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

CCHCR_MOUSE
NC score	0.053123 (rank : 1051)	θ value	θ > 10 (rank : 1328)
Query Neighborhood Hits	1311	Target Neighborhood Hits	932	Shared Neighborhood Hits	251
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

ROBO3_MOUSE
NC score	0.052928 (rank : 1052)	θ value	θ > 10 (rank : 1460)
Query Neighborhood Hits	1311	Target Neighborhood Hits	524	Shared Neighborhood Hits	91
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

OFD1_HUMAN
NC score	0.052782 (rank : 1053)	θ value	3.0926 (rank : 1136)
Query Neighborhood Hits	1311	Target Neighborhood Hits	753	Shared Neighborhood Hits	197
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

NCA11_HUMAN
NC score	0.052758 (rank : 1054)	θ value	θ > 10 (rank : 1405)
Query Neighborhood Hits	1311	Target Neighborhood Hits	443	Shared Neighborhood Hits	73
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

PHLB2_MOUSE
NC score	0.052698 (rank : 1055)	θ value	θ > 10 (rank : 1433)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1016	Shared Neighborhood Hits	283
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

CAF1A_HUMAN
NC score	0.052578 (rank : 1056)	θ value	0.47712 (rank : 956)
Query Neighborhood Hits	1311	Target Neighborhood Hits	750	Shared Neighborhood Hits	197
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

RAD50_MOUSE
NC score	0.052433 (rank : 1057)	θ value	θ > 10 (rank : 1447)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1366	Shared Neighborhood Hits	295
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

GRB7_MOUSE
NC score	0.052281 (rank : 1058)	θ value	θ > 10 (rank : 1380)
Query Neighborhood Hits	1311	Target Neighborhood Hits	157	Shared Neighborhood Hits	48
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

CROCC_MOUSE
NC score	0.052192 (rank : 1059)	θ value	0.62314 (rank : 970)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1460	Shared Neighborhood Hits	298
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

NCA12_HUMAN
NC score	0.052137 (rank : 1060)	θ value	θ > 10 (rank : 1406)
Query Neighborhood Hits	1311	Target Neighborhood Hits	437	Shared Neighborhood Hits	73
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

TRIPB_HUMAN
NC score	0.052125 (rank : 1061)	θ value	0.813845 (rank : 1006)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1587	Shared Neighborhood Hits	325
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

CT2NL_HUMAN
NC score	0.052098 (rank : 1062)	θ value	4.03905 (rank : 1160)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1059	Shared Neighborhood Hits	288
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

GRAP1_HUMAN
NC score	0.052050 (rank : 1063)	θ value	θ > 10 (rank : 1370)
Query Neighborhood Hits	1311	Target Neighborhood Hits	944	Shared Neighborhood Hits	236
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

CT2NL_MOUSE
NC score	0.052038 (rank : 1064)	θ value	5.27518 (rank : 1200)
Query Neighborhood Hits	1311	Target Neighborhood Hits	902	Shared Neighborhood Hits	272
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

LNK_HUMAN
NC score	0.051999 (rank : 1065)	θ value	θ > 10 (rank : 1392)
Query Neighborhood Hits	1311	Target Neighborhood Hits	151	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

RAD50_HUMAN
NC score	0.051943 (rank : 1066)	θ value	0.0330416 (rank : 852)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1317	Shared Neighborhood Hits	296
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

CASP_MOUSE
NC score	0.051921 (rank : 1067)	θ value	0.0431538 (rank : 854)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1152	Shared Neighborhood Hits	279
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

HIP1_HUMAN
NC score	0.051764 (rank : 1068)	θ value	θ > 10 (rank : 1382)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1016	Shared Neighborhood Hits	268
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

DGKG_MOUSE
NC score	0.051761 (rank : 1069)	θ value	θ > 10 (rank : 1357)
Query Neighborhood Hits	1311	Target Neighborhood Hits	188	Shared Neighborhood Hits	37
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

REST_HUMAN
NC score	0.051657 (rank : 1070)	θ value	0.0252991 (rank : 850)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1605	Shared Neighborhood Hits	334
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SHB_MOUSE
NC score	0.051550 (rank : 1071)	θ value	θ > 10 (rank : 1473)
Query Neighborhood Hits	1311	Target Neighborhood Hits	137	Shared Neighborhood Hits	47
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

CAF1A_MOUSE
NC score	0.051547 (rank : 1072)	θ value	0.279714 (rank : 920)
Query Neighborhood Hits	1311	Target Neighborhood Hits	736	Shared Neighborhood Hits	202
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CASP_HUMAN
NC score	0.051529 (rank : 1073)	θ value	0.0736092 (rank : 874)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1131	Shared Neighborhood Hits	280
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

AKAP9_HUMAN
NC score	0.051502 (rank : 1074)	θ value	1.38821 (rank : 1029)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1710	Shared Neighborhood Hits	325
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

GOGA6_HUMAN
NC score	0.051427 (rank : 1075)	θ value	θ > 10 (rank : 1369)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1007	Shared Neighborhood Hits	251
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

TSC1_HUMAN
NC score	0.051418 (rank : 1076)	θ value	θ > 10 (rank : 1489)
Query Neighborhood Hits	1311	Target Neighborhood Hits	765	Shared Neighborhood Hits	188
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

RBCC1_HUMAN
NC score	0.051403 (rank : 1077)	θ value	θ > 10 (rank : 1451)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1023	Shared Neighborhood Hits	243
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

GOGA1_MOUSE
NC score	0.051351 (rank : 1078)	θ value	θ > 10 (rank : 1367)
Query Neighborhood Hits	1311	Target Neighborhood Hits	994	Shared Neighborhood Hits	246
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

PTPRD_HUMAN
NC score	0.051312 (rank : 1079)	θ value	θ > 10 (rank : 1441)
Query Neighborhood Hits	1311	Target Neighborhood Hits	485	Shared Neighborhood Hits	90
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

CCD21_HUMAN
NC score	0.051253 (rank : 1080)	θ value	θ > 10 (rank : 1323)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1228	Shared Neighborhood Hits	308
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

LUZP1_MOUSE
NC score	0.051167 (rank : 1081)	θ value	θ > 10 (rank : 1394)
Query Neighborhood Hits	1311	Target Neighborhood Hits	940	Shared Neighborhood Hits	253
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

PUNC_HUMAN
NC score	0.051056 (rank : 1082)	θ value	θ > 10 (rank : 1445)
Query Neighborhood Hits	1311	Target Neighborhood Hits	449	Shared Neighborhood Hits	69
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

GOGA5_MOUSE
NC score	0.051040 (rank : 1083)	θ value	θ > 10 (rank : 1368)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1434	Shared Neighborhood Hits	316
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

CP135_MOUSE
NC score	0.050999 (rank : 1084)	θ value	0.0961366 (rank : 880)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1278	Shared Neighborhood Hits	279
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CK5P2_HUMAN
NC score	0.050987 (rank : 1085)	θ value	3.0926 (rank : 1121)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1433	Shared Neighborhood Hits	324
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

MFAP1_HUMAN
NC score	0.050968 (rank : 1086)	θ value	0.125558 (rank : 893)
Query Neighborhood Hits	1311	Target Neighborhood Hits	321	Shared Neighborhood Hits	125
SwissProt Accessions	P55081	Gene names	MFAP1
Domain Architecture
Description	Microfibrillar-associated protein 1.

SH24A_MOUSE
NC score	0.050941 (rank : 1087)	θ value	θ > 10 (rank : 1472)
Query Neighborhood Hits	1311	Target Neighborhood Hits	326	Shared Neighborhood Hits	135
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

PTPRD_MOUSE
NC score	0.050833 (rank : 1088)	θ value	θ > 10 (rank : 1442)
Query Neighborhood Hits	1311	Target Neighborhood Hits	491	Shared Neighborhood Hits	88
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

BOC_HUMAN
NC score	0.050812 (rank : 1089)	θ value	θ > 10 (rank : 1317)
Query Neighborhood Hits	1311	Target Neighborhood Hits	543	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

PHLB2_HUMAN
NC score	0.050688 (rank : 1090)	θ value	θ > 10 (rank : 1432)
Query Neighborhood Hits	1311	Target Neighborhood Hits	964	Shared Neighborhood Hits	265
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

RABE1_MOUSE
NC score	0.050649 (rank : 1091)	θ value	3.0926 (rank : 1139)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1105	Shared Neighborhood Hits	265
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

SHC1_HUMAN
NC score	0.050624 (rank : 1092)	θ value	θ > 10 (rank : 1474)
Query Neighborhood Hits	1311	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

CNTN2_HUMAN
NC score	0.050598 (rank : 1093)	θ value	θ > 10 (rank : 1340)
Query Neighborhood Hits	1311	Target Neighborhood Hits	440	Shared Neighborhood Hits	85
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

FLIP1_HUMAN
NC score	0.050566 (rank : 1094)	θ value	1.81305 (rank : 1063)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1405	Shared Neighborhood Hits	306
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

PTPRS_HUMAN
NC score	0.050461 (rank : 1095)	θ value	θ > 10 (rank : 1444)
Query Neighborhood Hits	1311	Target Neighborhood Hits	472	Shared Neighborhood Hits	93
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

CNTN2_MOUSE
NC score	0.050433 (rank : 1096)	θ value	θ > 10 (rank : 1341)
Query Neighborhood Hits	1311	Target Neighborhood Hits	450	Shared Neighborhood Hits	84
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

RIOK2_MOUSE
NC score	0.050402 (rank : 1097)	θ value	θ > 10 (rank : 1453)
Query Neighborhood Hits	1311	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CQS5, Q91XF3	Gene names	Riok2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2).

GLE1_MOUSE
NC score	0.050336 (rank : 1098)	θ value	θ > 10 (rank : 1366)
Query Neighborhood Hits	1311	Target Neighborhood Hits	504	Shared Neighborhood Hits	182
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

SHC1_MOUSE
NC score	0.050269 (rank : 1099)	θ value	θ > 10 (rank : 1475)
Query Neighborhood Hits	1311	Target Neighborhood Hits	180	Shared Neighborhood Hits	50
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

CDON_HUMAN
NC score	0.050257 (rank : 1100)	θ value	θ > 10 (rank : 1329)
Query Neighborhood Hits	1311	Target Neighborhood Hits	412	Shared Neighborhood Hits	65
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

SHC2_HUMAN
NC score	0.050208 (rank : 1101)	θ value	θ > 10 (rank : 1476)
Query Neighborhood Hits	1311	Target Neighborhood Hits	170	Shared Neighborhood Hits	47
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

CROCC_HUMAN
NC score	0.050191 (rank : 1102)	θ value	5.27518 (rank : 1199)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1409	Shared Neighborhood Hits	277
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

AZI1_MOUSE
NC score	0.050136 (rank : 1103)	θ value	θ > 10 (rank : 1316)
Query Neighborhood Hits	1311	Target Neighborhood Hits	990	Shared Neighborhood Hits	240
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

SPN90_HUMAN
NC score	0.050127 (rank : 1104)	θ value	θ > 10 (rank : 1483)
Query Neighborhood Hits	1311	Target Neighborhood Hits	157	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

PTPRF_HUMAN
NC score	0.050057 (rank : 1105)	θ value	θ > 10 (rank : 1443)
Query Neighborhood Hits	1311	Target Neighborhood Hits	489	Shared Neighborhood Hits	92
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

KTN1_MOUSE
NC score	0.050025 (rank : 1106)	θ value	θ > 10 (rank : 1389)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1324	Shared Neighborhood Hits	297
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

CEP63_HUMAN
NC score	0.050024 (rank : 1107)	θ value	θ > 10 (rank : 1330)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1005	Shared Neighborhood Hits	251
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

NIN_HUMAN
NC score	0.049623 (rank : 1108)	θ value	6.88961 (rank : 1244)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1416	Shared Neighborhood Hits	296
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

HIP1R_MOUSE
NC score	0.049335 (rank : 1109)	θ value	8.99809 (rank : 1276)
Query Neighborhood Hits	1311	Target Neighborhood Hits	959	Shared Neighborhood Hits	258
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

GOGA3_MOUSE
NC score	0.049319 (rank : 1110)	θ value	0.00665767 (rank : 830)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1437	Shared Neighborhood Hits	294
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

RPGR_HUMAN
NC score	0.049227 (rank : 1111)	θ value	3.0926 (rank : 1141)
Query Neighborhood Hits	1311	Target Neighborhood Hits	279	Shared Neighborhood Hits	108
SwissProt Accessions	Q92834, O00702, O00737, Q8N5T6, Q93039, Q9HD29, Q9UMR1	Gene names	RPGR, RP3, XLRP3
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator.

BPAEA_MOUSE
NC score	0.049161 (rank : 1112)	θ value	1.38821 (rank : 1033)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1480	Shared Neighborhood Hits	319
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

MFAP1_MOUSE
NC score	0.049075 (rank : 1113)	θ value	0.813845 (rank : 999)
Query Neighborhood Hits	1311	Target Neighborhood Hits	353	Shared Neighborhood Hits	122
SwissProt Accessions	Q9CQU1, Q3TU29, Q8CCL1, Q9CSJ5	Gene names	Mfap1
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 1.

GCC2_MOUSE
NC score	0.049071 (rank : 1114)	θ value	0.0148317 (rank : 840)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1619	Shared Neighborhood Hits	313
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

KMHN1_HUMAN
NC score	0.048984 (rank : 1115)	θ value	1.06291 (rank : 1017)
Query Neighborhood Hits	1311	Target Neighborhood Hits	950	Shared Neighborhood Hits	244
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

SMC2_HUMAN
NC score	0.048464 (rank : 1116)	θ value	6.88961 (rank : 1253)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1405	Shared Neighborhood Hits	320
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

CENPF_HUMAN
NC score	0.048263 (rank : 1117)	θ value	5.27518 (rank : 1192)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1932	Shared Neighborhood Hits	340
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

SM1L2_MOUSE
NC score	0.048223 (rank : 1118)	θ value	4.03905 (rank : 1179)
Query Neighborhood Hits	1311	Target Neighborhood Hits	918	Shared Neighborhood Hits	236
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

ANR26_MOUSE
NC score	0.047667 (rank : 1119)	θ value	8.99809 (rank : 1261)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1554	Shared Neighborhood Hits	308
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

MAP1B_MOUSE
NC score	0.047649 (rank : 1120)	θ value	0.0961366 (rank : 882)
Query Neighborhood Hits	1311	Target Neighborhood Hits	977	Shared Neighborhood Hits	222
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

CN145_MOUSE
NC score	0.047456 (rank : 1121)	θ value	5.27518 (rank : 1197)
Query Neighborhood Hits	1311	Target Neighborhood Hits	916	Shared Neighborhood Hits	226
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

BSN_HUMAN
NC score	0.047449 (rank : 1122)	θ value	1.06291 (rank : 1010)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1537	Shared Neighborhood Hits	256
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

WDR67_HUMAN
NC score	0.047444 (rank : 1123)	θ value	8.99809 (rank : 1311)
Query Neighborhood Hits	1311	Target Neighborhood Hits	782	Shared Neighborhood Hits	214
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

REST_MOUSE
NC score	0.047306 (rank : 1124)	θ value	2.36792 (rank : 1103)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1506	Shared Neighborhood Hits	308
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SYCP1_MOUSE
NC score	0.047212 (rank : 1125)	θ value	6.88961 (rank : 1256)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1456	Shared Neighborhood Hits	312
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

TNNT2_HUMAN
NC score	0.046909 (rank : 1126)	θ value	2.36792 (rank : 1113)
Query Neighborhood Hits	1311	Target Neighborhood Hits	433	Shared Neighborhood Hits	147
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

IWS1_HUMAN
NC score	0.046836 (rank : 1127)	θ value	0.47712 (rank : 964)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1241	Shared Neighborhood Hits	285
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

IWS1_MOUSE
NC score	0.046804 (rank : 1128)	θ value	0.000121331 (rank : 799)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1258	Shared Neighborhood Hits	273
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NUMA1_HUMAN
NC score	0.046784 (rank : 1129)	θ value	2.36792 (rank : 1101)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1523	Shared Neighborhood Hits	282
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

TNIP3_HUMAN
NC score	0.046759 (rank : 1130)	θ value	2.36792 (rank : 1112)
Query Neighborhood Hits	1311	Target Neighborhood Hits	511	Shared Neighborhood Hits	161
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

TAXB1_MOUSE
NC score	0.046712 (rank : 1131)	θ value	0.365318 (rank : 953)
Query Neighborhood Hits	1311	Target Neighborhood Hits	886	Shared Neighborhood Hits	225
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

NAF1_MOUSE
NC score	0.046499 (rank : 1132)	θ value	5.27518 (rank : 1210)
Query Neighborhood Hits	1311	Target Neighborhood Hits	852	Shared Neighborhood Hits	232
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

MYO5C_HUMAN
NC score	0.046472 (rank : 1133)	θ value	2.36792 (rank : 1094)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1206	Shared Neighborhood Hits	293
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

CENPE_HUMAN
NC score	0.046443 (rank : 1134)	θ value	0.279714 (rank : 921)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2060	Shared Neighborhood Hits	369
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

GCP60_HUMAN
NC score	0.045907 (rank : 1135)	θ value	0.47712 (rank : 960)
Query Neighborhood Hits	1311	Target Neighborhood Hits	419	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H3P7, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3	Gene names	ACBD3, GCP60
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

HMMR_HUMAN
NC score	0.045639 (rank : 1136)	θ value	5.27518 (rank : 1204)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1082	Shared Neighborhood Hits	238
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

LUZP1_HUMAN
NC score	0.045411 (rank : 1137)	θ value	0.279714 (rank : 928)
Query Neighborhood Hits	1311	Target Neighborhood Hits	739	Shared Neighborhood Hits	189
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

ANR26_HUMAN
NC score	0.045408 (rank : 1138)	θ value	3.0926 (rank : 1117)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1614	Shared Neighborhood Hits	322
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

MYH11_HUMAN
NC score	0.045265 (rank : 1139)	θ value	1.81305 (rank : 1067)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1806	Shared Neighborhood Hits	349
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH9_MOUSE
NC score	0.045135 (rank : 1140)	θ value	8.99809 (rank : 1285)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1829	Shared Neighborhood Hits	347
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_HUMAN
NC score	0.044948 (rank : 1141)	θ value	2.36792 (rank : 1093)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1762	Shared Neighborhood Hits	343
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

ACINU_MOUSE
NC score	0.044944 (rank : 1142)	θ value	4.03905 (rank : 1155)
Query Neighborhood Hits	1311	Target Neighborhood Hits	712	Shared Neighborhood Hits	200
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BSN_MOUSE
NC score	0.044732 (rank : 1143)	θ value	0.125558 (rank : 887)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2057	Shared Neighborhood Hits	277
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

LEO1_HUMAN
NC score	0.044650 (rank : 1144)	θ value	1.81305 (rank : 1066)
Query Neighborhood Hits	1311	Target Neighborhood Hits	958	Shared Neighborhood Hits	250
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

ERC2_MOUSE
NC score	0.044575 (rank : 1145)	θ value	8.99809 (rank : 1274)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1166	Shared Neighborhood Hits	257
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

UACA_MOUSE
NC score	0.044525 (rank : 1146)	θ value	3.0926 (rank : 1152)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1620	Shared Neighborhood Hits	312
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

SFR12_HUMAN
NC score	0.044491 (rank : 1147)	θ value	3.0926 (rank : 1143)
Query Neighborhood Hits	1311	Target Neighborhood Hits	553	Shared Neighborhood Hits	141
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

DREB_HUMAN
NC score	0.044188 (rank : 1148)	θ value	1.38821 (rank : 1037)
Query Neighborhood Hits	1311	Target Neighborhood Hits	450	Shared Neighborhood Hits	136
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

MYH14_MOUSE
NC score	0.043763 (rank : 1149)	θ value	0.47712 (rank : 967)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1225	Shared Neighborhood Hits	260
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

BRE1A_MOUSE
NC score	0.043714 (rank : 1150)	θ value	0.0563607 (rank : 865)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1025	Shared Neighborhood Hits	206
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

KTN1_HUMAN
NC score	0.043695 (rank : 1151)	θ value	6.88961 (rank : 1239)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1197	Shared Neighborhood Hits	245
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

MAP9_HUMAN
NC score	0.043686 (rank : 1152)	θ value	4.03905 (rank : 1167)
Query Neighborhood Hits	1311	Target Neighborhood Hits	518	Shared Neighborhood Hits	159
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

CUTL1_MOUSE
NC score	0.043577 (rank : 1153)	θ value	1.06291 (rank : 1011)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1620	Shared Neighborhood Hits	307
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

GCP60_MOUSE
NC score	0.043098 (rank : 1154)	θ value	1.38821 (rank : 1039)
Query Neighborhood Hits	1311	Target Neighborhood Hits	395	Shared Neighborhood Hits	128
SwissProt Accessions	Q8BMP6, O35371	Gene names	Acbd3, Gcp60, Pap7
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

MYH10_MOUSE
NC score	0.043073 (rank : 1155)	θ value	8.99809 (rank : 1284)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1612	Shared Neighborhood Hits	313
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

BAZ2B_HUMAN
NC score	0.042772 (rank : 1156)	θ value	0.00134147 (rank : 814)
Query Neighborhood Hits	1311	Target Neighborhood Hits	803	Shared Neighborhood Hits	216
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BRE1A_HUMAN
NC score	0.042561 (rank : 1157)	θ value	1.38821 (rank : 1034)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1071	Shared Neighborhood Hits	213
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

CUTL1_HUMAN
NC score	0.042478 (rank : 1158)	θ value	0.365318 (rank : 941)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1574	Shared Neighborhood Hits	311
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

ERC2_HUMAN
NC score	0.041889 (rank : 1159)	θ value	3.0926 (rank : 1127)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1156	Shared Neighborhood Hits	249
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

EEA1_MOUSE
NC score	0.041346 (rank : 1160)	θ value	8.99809 (rank : 1271)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1637	Shared Neighborhood Hits	319
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SPAG5_MOUSE
NC score	0.041277 (rank : 1161)	θ value	0.125558 (rank : 897)
Query Neighborhood Hits	1311	Target Neighborhood Hits	612	Shared Neighborhood Hits	160
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

TNNT2_MOUSE
NC score	0.041216 (rank : 1162)	θ value	8.99809 (rank : 1307)
Query Neighborhood Hits	1311	Target Neighborhood Hits	395	Shared Neighborhood Hits	145
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

T2_MOUSE
NC score	0.041039 (rank : 1163)	θ value	0.813845 (rank : 1003)
Query Neighborhood Hits	1311	Target Neighborhood Hits	140	Shared Neighborhood Hits	51
SwissProt Accessions	Q06666	Gene names	Srst, T2
Domain Architecture	No domain graphic available
Description	Octapeptide-repeat protein T2.

BICD1_HUMAN
NC score	0.040985 (rank : 1164)	θ value	0.813845 (rank : 987)
Query Neighborhood Hits	1311	Target Neighborhood Hits	844	Shared Neighborhood Hits	210
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD1_MOUSE
NC score	0.040693 (rank : 1165)	θ value	0.813845 (rank : 988)
Query Neighborhood Hits	1311	Target Neighborhood Hits	837	Shared Neighborhood Hits	211
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

SAFB2_HUMAN
NC score	0.040321 (rank : 1166)	θ value	0.365318 (rank : 950)
Query Neighborhood Hits	1311	Target Neighborhood Hits	720	Shared Neighborhood Hits	194
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

HOOK3_HUMAN
NC score	0.040268 (rank : 1167)	θ value	1.06291 (rank : 1016)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1070	Shared Neighborhood Hits	247
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

RPGR1_MOUSE
NC score	0.040252 (rank : 1168)	θ value	0.0431538 (rank : 859)
Query Neighborhood Hits	1311	Target Neighborhood Hits	713	Shared Neighborhood Hits	199
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SFR17_HUMAN
NC score	0.040247 (rank : 1169)	θ value	0.0431538 (rank : 861)
Query Neighborhood Hits	1311	Target Neighborhood Hits	325	Shared Neighborhood Hits	101
SwissProt Accessions	Q8TF01, Q5T064, Q6P2B4, Q6P2N4, Q6PJ93, Q6PK36, Q7Z640, Q8TF00, Q96K10, Q96SM5, Q9P076, Q9P0C0, Q9Y4N3	Gene names	SRRP130, C6orf111
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 130 (Serine-arginine-rich- splicing regulatory protein 130) (SRrp130) (SR-rich protein) (SR- related protein).

U2AFM_MOUSE
NC score	0.040199 (rank : 1170)	θ value	0.0563607 (rank : 871)
Query Neighborhood Hits	1311	Target Neighborhood Hits	543	Shared Neighborhood Hits	149
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

DREB_MOUSE
NC score	0.040159 (rank : 1171)	θ value	1.81305 (rank : 1060)
Query Neighborhood Hits	1311	Target Neighborhood Hits	446	Shared Neighborhood Hits	137
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

CROP_HUMAN
NC score	0.040111 (rank : 1172)	θ value	3.0926 (rank : 1124)
Query Neighborhood Hits	1311	Target Neighborhood Hits	402	Shared Neighborhood Hits	127
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

MAP1B_HUMAN
NC score	0.040098 (rank : 1173)	θ value	0.365318 (rank : 944)
Query Neighborhood Hits	1311	Target Neighborhood Hits	903	Shared Neighborhood Hits	220
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

PLEC1_HUMAN
NC score	0.039779 (rank : 1174)	θ value	0.0193708 (rank : 845)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1326	Shared Neighborhood Hits	247
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

TXND2_MOUSE
NC score	0.039653 (rank : 1175)	θ value	0.125558 (rank : 898)
Query Neighborhood Hits	1311	Target Neighborhood Hits	828	Shared Neighborhood Hits	226
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

UACA_HUMAN
NC score	0.039559 (rank : 1176)	θ value	5.27518 (rank : 1221)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1622	Shared Neighborhood Hits	296
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

ANR12_HUMAN
NC score	0.039461 (rank : 1177)	θ value	0.47712 (rank : 954)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1081	Shared Neighborhood Hits	240
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

KIF4A_HUMAN
NC score	0.039157 (rank : 1178)	θ value	0.00665767 (rank : 831)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1159	Shared Neighborhood Hits	275
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MYO10_HUMAN
NC score	0.038897 (rank : 1179)	θ value	0.279714 (rank : 929)
Query Neighborhood Hits	1311	Target Neighborhood Hits	920	Shared Neighborhood Hits	243
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

LEO1_MOUSE
NC score	0.038871 (rank : 1180)	θ value	4.03905 (rank : 1164)
Query Neighborhood Hits	1311	Target Neighborhood Hits	946	Shared Neighborhood Hits	247
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

TAF3_MOUSE
NC score	0.038781 (rank : 1181)	θ value	0.813845 (rank : 1004)
Query Neighborhood Hits	1311	Target Neighborhood Hits	463	Shared Neighborhood Hits	124
SwissProt Accessions	Q5HZG4, Q3U490, Q3UWX2, Q8BIU8, Q99JH4	Gene names	Taf3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

LRRF1_HUMAN
NC score	0.038518 (rank : 1182)	θ value	0.0961366 (rank : 881)
Query Neighborhood Hits	1311	Target Neighborhood Hits	625	Shared Neighborhood Hits	215
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

RENT2_HUMAN
NC score	0.038463 (rank : 1183)	θ value	1.81305 (rank : 1070)
Query Neighborhood Hits	1311	Target Neighborhood Hits	618	Shared Neighborhood Hits	169
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

PHLB1_HUMAN
NC score	0.038463 (rank : 1184)	θ value	4.03905 (rank : 1172)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1038	Shared Neighborhood Hits	225
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

NUF2_HUMAN
NC score	0.038225 (rank : 1185)	θ value	5.27518 (rank : 1211)
Query Neighborhood Hits	1311	Target Neighborhood Hits	661	Shared Neighborhood Hits	180
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

ENAH_MOUSE
NC score	0.038057 (rank : 1186)	θ value	0.0113563 (rank : 835)
Query Neighborhood Hits	1311	Target Neighborhood Hits	919	Shared Neighborhood Hits	182
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

NEBL_HUMAN
NC score	0.037960 (rank : 1187)	θ value	2.36792 (rank : 1097)
Query Neighborhood Hits	1311	Target Neighborhood Hits	457	Shared Neighborhood Hits	150
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

U2AFM_HUMAN
NC score	0.037926 (rank : 1188)	θ value	0.813845 (rank : 1007)
Query Neighborhood Hits	1311	Target Neighborhood Hits	577	Shared Neighborhood Hits	157
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

HIP1R_HUMAN
NC score	0.037846 (rank : 1189)	θ value	6.88961 (rank : 1237)
Query Neighborhood Hits	1311	Target Neighborhood Hits	809	Shared Neighborhood Hits	220
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

CDR2_MOUSE
NC score	0.037794 (rank : 1190)	θ value	1.81305 (rank : 1056)
Query Neighborhood Hits	1311	Target Neighborhood Hits	482	Shared Neighborhood Hits	155
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

HOOK3_MOUSE
NC score	0.037508 (rank : 1191)	θ value	4.03905 (rank : 1161)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1007	Shared Neighborhood Hits	230
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

DYNA_HUMAN
NC score	0.037241 (rank : 1192)	θ value	6.88961 (rank : 1234)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1194	Shared Neighborhood Hits	264
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

CROP_MOUSE
NC score	0.037103 (rank : 1193)	θ value	8.99809 (rank : 1266)
Query Neighborhood Hits	1311	Target Neighborhood Hits	403	Shared Neighborhood Hits	124
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

SMC4_MOUSE
NC score	0.037038 (rank : 1194)	θ value	5.27518 (rank : 1216)
Query Neighborhood Hits	1311	Target Neighborhood Hits	830	Shared Neighborhood Hits	185
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

TXND2_HUMAN
NC score	0.036704 (rank : 1195)	θ value	0.163984 (rank : 909)
Query Neighborhood Hits	1311	Target Neighborhood Hits	793	Shared Neighborhood Hits	164
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

FYCO1_MOUSE
NC score	0.036218 (rank : 1196)	θ value	1.81305 (rank : 1064)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1059	Shared Neighborhood Hits	226
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

RP1L1_HUMAN
NC score	0.035876 (rank : 1197)	θ value	0.365318 (rank : 949)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1072	Shared Neighborhood Hits	190
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

DYNA_MOUSE
NC score	0.035772 (rank : 1198)	θ value	3.0926 (rank : 1126)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1084	Shared Neighborhood Hits	239
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

CS029_HUMAN
NC score	0.035716 (rank : 1199)	θ value	8.99809 (rank : 1267)
Query Neighborhood Hits	1311	Target Neighborhood Hits	329	Shared Neighborhood Hits	146
SwissProt Accessions	Q8WUQ7, O75229, Q7LE08, Q9BTA6, Q9Y5A4	Gene names	C19orf29
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf29 (NY-REN-24 antigen).

CR034_MOUSE
NC score	0.035708 (rank : 1200)	θ value	0.47712 (rank : 958)
Query Neighborhood Hits	1311	Target Neighborhood Hits	643	Shared Neighborhood Hits	176
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

SAFB2_MOUSE
NC score	0.035275 (rank : 1201)	θ value	1.06291 (rank : 1024)
Query Neighborhood Hits	1311	Target Neighborhood Hits	581	Shared Neighborhood Hits	154
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

DMP1_HUMAN
NC score	0.035024 (rank : 1202)	θ value	0.62314 (rank : 972)
Query Neighborhood Hits	1311	Target Neighborhood Hits	491	Shared Neighborhood Hits	148
SwissProt Accessions	Q13316, O43265	Gene names	DMP1
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1).

PLCB1_HUMAN
NC score	0.034855 (rank : 1203)	θ value	4.03905 (rank : 1173)
Query Neighborhood Hits	1311	Target Neighborhood Hits	614	Shared Neighborhood Hits	184
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

RUFY2_HUMAN
NC score	0.034573 (rank : 1204)	θ value	6.88961 (rank : 1249)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1208	Shared Neighborhood Hits	261
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TAF3_HUMAN
NC score	0.033997 (rank : 1205)	θ value	0.365318 (rank : 952)
Query Neighborhood Hits	1311	Target Neighborhood Hits	568	Shared Neighborhood Hits	138
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

RABE2_HUMAN
NC score	0.033917 (rank : 1206)	θ value	6.88961 (rank : 1247)
Query Neighborhood Hits	1311	Target Neighborhood Hits	545	Shared Neighborhood Hits	173
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

CC47_MOUSE
NC score	0.033546 (rank : 1207)	θ value	0.125558 (rank : 888)
Query Neighborhood Hits	1311	Target Neighborhood Hits	245	Shared Neighborhood Hits	116
SwissProt Accessions	Q9D024, Q3TSB5, Q3V1S7, Q8C5D9, Q920S6	Gene names	Ccdc47, Asp4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor (Adipocyte-specific protein 4).

NFH_MOUSE
NC score	0.033298 (rank : 1208)	θ value	0.21417 (rank : 914)
Query Neighborhood Hits	1311	Target Neighborhood Hits	2247	Shared Neighborhood Hits	350
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CTGE5_MOUSE
NC score	0.032918 (rank : 1209)	θ value	1.38821 (rank : 1036)
Query Neighborhood Hits	1311	Target Neighborhood Hits	928	Shared Neighborhood Hits	232
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

NSBP1_MOUSE
NC score	0.032770 (rank : 1210)	θ value	4.03905 (rank : 1170)
Query Neighborhood Hits	1311	Target Neighborhood Hits	681	Shared Neighborhood Hits	201
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

DSPP_MOUSE
NC score	0.032358 (rank : 1211)	θ value	0.00134147 (rank : 815)
Query Neighborhood Hits	1311	Target Neighborhood Hits	491	Shared Neighborhood Hits	104
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

TCAL5_HUMAN
NC score	0.032023 (rank : 1212)	θ value	0.62314 (rank : 980)
Query Neighborhood Hits	1311	Target Neighborhood Hits	806	Shared Neighborhood Hits	210
SwissProt Accessions	Q5H9L2	Gene names	TCEAL5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

VDP_HUMAN
NC score	0.032020 (rank : 1213)	θ value	2.36792 (rank : 1115)
Query Neighborhood Hits	1311	Target Neighborhood Hits	645	Shared Neighborhood Hits	161
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

AFAD_HUMAN
NC score	0.031971 (rank : 1214)	θ value	1.06291 (rank : 1009)
Query Neighborhood Hits	1311	Target Neighborhood Hits	689	Shared Neighborhood Hits	161
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

TEX9_MOUSE
NC score	0.031752 (rank : 1215)	θ value	2.36792 (rank : 1111)
Query Neighborhood Hits	1311	Target Neighborhood Hits	581	Shared Neighborhood Hits	177
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

RBBP6_HUMAN
NC score	0.031748 (rank : 1216)	θ value	3.0926 (rank : 1140)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1135	Shared Neighborhood Hits	231
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

REN3A_HUMAN
NC score	0.031745 (rank : 1217)	θ value	4.03905 (rank : 1175)
Query Neighborhood Hits	1311	Target Neighborhood Hits	248	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H1J1, Q5T8C3, Q5T8C9, Q7Z6N3, Q86YK1, Q9BZI8	Gene names	UPF3A, RENT3A, UPF3
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3).

ARI4A_HUMAN
NC score	0.031718 (rank : 1218)	θ value	1.81305 (rank : 1053)
Query Neighborhood Hits	1311	Target Neighborhood Hits	434	Shared Neighborhood Hits	131
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

CLSPN_HUMAN
NC score	0.031589 (rank : 1219)	θ value	2.36792 (rank : 1086)
Query Neighborhood Hits	1311	Target Neighborhood Hits	433	Shared Neighborhood Hits	145
SwissProt Accessions	Q9HAW4, Q5VYG0, Q6P6H5, Q8IWI1	Gene names	CLSPN
Domain Architecture	No domain graphic available
Description	Claspin (hClaspin) (Hu-Claspin).

MYO6_MOUSE
NC score	0.031124 (rank : 1220)	θ value	6.88961 (rank : 1241)
Query Neighborhood Hits	1311	Target Neighborhood Hits	586	Shared Neighborhood Hits	166
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

HTSF1_HUMAN
NC score	0.031124 (rank : 1221)	θ value	0.0736092 (rank : 875)
Query Neighborhood Hits	1311	Target Neighborhood Hits	408	Shared Neighborhood Hits	108
SwissProt Accessions	O43719, Q59G06, Q99730	Gene names	HTATSF1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 (Tat-SF1).

TP53B_MOUSE
NC score	0.031110 (rank : 1222)	θ value	3.0926 (rank : 1151)
Query Neighborhood Hits	1311	Target Neighborhood Hits	644	Shared Neighborhood Hits	154
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

MOES_MOUSE
NC score	0.030961 (rank : 1223)	θ value	5.27518 (rank : 1208)
Query Neighborhood Hits	1311	Target Neighborhood Hits	923	Shared Neighborhood Hits	213
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MINT_MOUSE
NC score	0.030839 (rank : 1224)	θ value	0.47712 (rank : 966)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1514	Shared Neighborhood Hits	243
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

BAZ1B_HUMAN
NC score	0.030675 (rank : 1225)	θ value	6.88961 (rank : 1230)
Query Neighborhood Hits	1311	Target Neighborhood Hits	701	Shared Neighborhood Hits	216
SwissProt Accessions	Q9UIG0, O95039, O95247, O95277	Gene names	BAZ1B, WBSC10, WBSCR9, WSTF
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1B (Williams-Beuren syndrome chromosome region 9 protein) (Williams syndrome transcription factor) (hWALP2).

DSPP_HUMAN
NC score	0.030564 (rank : 1226)	θ value	0.00509761 (rank : 827)
Query Neighborhood Hits	1311	Target Neighborhood Hits	645	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

MOES_HUMAN
NC score	0.030417 (rank : 1227)	θ value	6.88961 (rank : 1240)
Query Neighborhood Hits	1311	Target Neighborhood Hits	892	Shared Neighborhood Hits	212
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

NFM_HUMAN
NC score	0.030396 (rank : 1228)	θ value	0.0252991 (rank : 848)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1328	Shared Neighborhood Hits	292
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

3BP5_HUMAN
NC score	0.030304 (rank : 1229)	θ value	4.03905 (rank : 1154)
Query Neighborhood Hits	1311	Target Neighborhood Hits	375	Shared Neighborhood Hits	120
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

PHLB1_MOUSE
NC score	0.030223 (rank : 1230)	θ value	0.279714 (rank : 932)
Query Neighborhood Hits	1311	Target Neighborhood Hits	678	Shared Neighborhood Hits	149
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PLCB2_HUMAN
NC score	0.030167 (rank : 1231)	θ value	6.88961 (rank : 1246)
Query Neighborhood Hits	1311	Target Neighborhood Hits	608	Shared Neighborhood Hits	203
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

ABTAP_MOUSE
NC score	0.029884 (rank : 1232)	θ value	2.36792 (rank : 1077)
Query Neighborhood Hits	1311	Target Neighborhood Hits	381	Shared Neighborhood Hits	130
SwissProt Accessions	Q3V1V3	Gene names	Abtap
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

VCX1_HUMAN
NC score	0.029680 (rank : 1233)	θ value	0.813845 (rank : 1008)
Query Neighborhood Hits	1311	Target Neighborhood Hits	129	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H320, Q9P0H3	Gene names	VCX, VCX1, VCX10R, VCXB1
Domain Architecture	No domain graphic available
Description	Variable charge X-linked protein 1 (VCX-B1 protein) (Variably charged protein X-B1) (Variable charge protein on X with ten repeats) (VCX- 10r).

PLCB1_MOUSE
NC score	0.029647 (rank : 1234)	θ value	6.88961 (rank : 1245)
Query Neighborhood Hits	1311	Target Neighborhood Hits	531	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

CLUA1_MOUSE
NC score	0.029351 (rank : 1235)	θ value	5.27518 (rank : 1195)
Query Neighborhood Hits	1311	Target Neighborhood Hits	261	Shared Neighborhood Hits	96
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

LIPB1_MOUSE
NC score	0.029159 (rank : 1236)	θ value	4.03905 (rank : 1165)
Query Neighborhood Hits	1311	Target Neighborhood Hits	727	Shared Neighborhood Hits	196
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

ANK2_HUMAN
NC score	0.028811 (rank : 1237)	θ value	0.279714 (rank : 919)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1615	Shared Neighborhood Hits	251
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

RSF1_HUMAN
NC score	0.028513 (rank : 1238)	θ value	0.813845 (rank : 1001)
Query Neighborhood Hits	1311	Target Neighborhood Hits	539	Shared Neighborhood Hits	146
SwissProt Accessions	Q96T23, Q86X86, Q9H3L8, Q9NVZ8, Q9NYU0	Gene names	RSF1, HBXAP, XAP8
Domain Architecture	No domain graphic available
Description	Remodeling and spacing factor 1 (Rsf-1) (Hepatitis B virus X- associated protein) (HBV pX-associated protein 8) (p325 subunit of RSF chromatin remodelling complex).

NFM_MOUSE
NC score	0.028084 (rank : 1239)	θ value	0.125558 (rank : 895)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1159	Shared Neighborhood Hits	276
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

PELP1_HUMAN
NC score	0.028030 (rank : 1240)	θ value	0.0563607 (rank : 870)
Query Neighborhood Hits	1311	Target Neighborhood Hits	596	Shared Neighborhood Hits	132
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

CCAR1_HUMAN
NC score	0.027984 (rank : 1241)	θ value	5.27518 (rank : 1189)
Query Neighborhood Hits	1311	Target Neighborhood Hits	444	Shared Neighborhood Hits	135
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

HTSF1_MOUSE
NC score	0.027952 (rank : 1242)	θ value	0.279714 (rank : 926)
Query Neighborhood Hits	1311	Target Neighborhood Hits	425	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BGC0, Q1WWK0, Q9CT41, Q9DAU3	Gene names	Htatsf1
Domain Architecture	No domain graphic available
Description	HIV Tat-specific factor 1 homolog.

ASPH_HUMAN
NC score	0.027730 (rank : 1243)	θ value	1.38821 (rank : 1030)
Query Neighborhood Hits	1311	Target Neighborhood Hits	158	Shared Neighborhood Hits	75
SwissProt Accessions	Q12797	Gene names	ASPH
Domain Architecture
Description	Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta- hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta- dioxygenase).

CDR2_HUMAN
NC score	0.027215 (rank : 1244)	θ value	4.03905 (rank : 1158)
Query Neighborhood Hits	1311	Target Neighborhood Hits	404	Shared Neighborhood Hits	127
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

CCAR1_MOUSE
NC score	0.027194 (rank : 1245)	θ value	2.36792 (rank : 1081)
Query Neighborhood Hits	1311	Target Neighborhood Hits	414	Shared Neighborhood Hits	135
SwissProt Accessions	Q8CH18, Q6AXC9, Q6PAR2, Q80XE4, Q8BJY0, Q8BVN2, Q8CGG1, Q9CSR5	Gene names	Ccar1, Carp1
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1).

CLUA1_HUMAN
NC score	0.026998 (rank : 1246)	θ value	0.365318 (rank : 940)
Query Neighborhood Hits	1311	Target Neighborhood Hits	236	Shared Neighborhood Hits	81
SwissProt Accessions	Q96AJ1, O75138, Q65ZA3, Q9H8R4, Q9H8T1	Gene names	CLUAP1, KIAA0643
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

PERQ1_MOUSE
NC score	0.026985 (rank : 1247)	θ value	3.0926 (rank : 1138)
Query Neighborhood Hits	1311	Target Neighborhood Hits	215	Shared Neighborhood Hits	73
SwissProt Accessions	Q99MR1	Gene names	Perq1
Domain Architecture
Description	PERQ amino acid rich with GYF domain protein 1.

KI21A_HUMAN
NC score	0.026811 (rank : 1248)	θ value	6.88961 (rank : 1238)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1543	Shared Neighborhood Hits	307
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

EP15_MOUSE
NC score	0.026759 (rank : 1249)	θ value	8.99809 (rank : 1273)
Query Neighborhood Hits	1311	Target Neighborhood Hits	820	Shared Neighborhood Hits	176
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

BAZ1A_HUMAN
NC score	0.026755 (rank : 1250)	θ value	1.38821 (rank : 1031)
Query Neighborhood Hits	1311	Target Neighborhood Hits	693	Shared Neighborhood Hits	186
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

MDN1_HUMAN
NC score	0.026418 (rank : 1251)	θ value	0.365318 (rank : 945)
Query Neighborhood Hits	1311	Target Neighborhood Hits	662	Shared Neighborhood Hits	171
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

SH3G2_HUMAN
NC score	0.026048 (rank : 1252)	θ value	6.88961 (rank : 1251)
Query Neighborhood Hits	1311	Target Neighborhood Hits	324	Shared Neighborhood Hits	78
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

PELP1_MOUSE
NC score	0.025898 (rank : 1253)	θ value	0.0252991 (rank : 849)
Query Neighborhood Hits	1311	Target Neighborhood Hits	709	Shared Neighborhood Hits	129
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

N4BP3_MOUSE
NC score	0.025649 (rank : 1254)	θ value	8.99809 (rank : 1286)
Query Neighborhood Hits	1311	Target Neighborhood Hits	179	Shared Neighborhood Hits	75
SwissProt Accessions	Q8C7U1, Q3TDC7, Q7TNR2, Q922W0, Q99J06	Gene names	N4bp3
Domain Architecture
Description	NEDD4-binding protein 3 (N4BP3).

NEB1_HUMAN
NC score	0.025561 (rank : 1255)	θ value	6.88961 (rank : 1243)
Query Neighborhood Hits	1311	Target Neighborhood Hits	829	Shared Neighborhood Hits	213
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

DMP1_MOUSE
NC score	0.025327 (rank : 1256)	θ value	0.163984 (rank : 901)
Query Neighborhood Hits	1311	Target Neighborhood Hits	498	Shared Neighborhood Hits	137
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

SON_HUMAN
NC score	0.024809 (rank : 1257)	θ value	0.813845 (rank : 1002)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1568	Shared Neighborhood Hits	182
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

VCXC_HUMAN
NC score	0.024696 (rank : 1258)	θ value	0.62314 (rank : 983)
Query Neighborhood Hits	1311	Target Neighborhood Hits	139	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H321	Gene names	VCXC
Domain Architecture	No domain graphic available
Description	VCX-C protein (Variably charged protein X-C).

U2AFL_MOUSE
NC score	0.024584 (rank : 1259)	θ value	1.81305 (rank : 1076)
Query Neighborhood Hits	1311	Target Neighborhood Hits	389	Shared Neighborhood Hits	113
SwissProt Accessions	Q64707	Gene names	Zrsr1, Sp2, Sp2-7, U2af1-rs1, U2af1l1
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (SP2).

CCDC9_MOUSE
NC score	0.024526 (rank : 1260)	θ value	0.0961366 (rank : 879)
Query Neighborhood Hits	1311	Target Neighborhood Hits	196	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VC31	Gene names	Ccdc9
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 9.

KI21A_MOUSE
NC score	0.024522 (rank : 1261)	θ value	0.0563607 (rank : 869)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1317	Shared Neighborhood Hits	282
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

ATRX_HUMAN
NC score	0.024506 (rank : 1262)	θ value	0.813845 (rank : 986)
Query Neighborhood Hits	1311	Target Neighborhood Hits	842	Shared Neighborhood Hits	222
SwissProt Accessions	P46100, P51068, Q15886, Q59FB5, Q59H31, Q5H9A2, Q5JWI4, Q7Z2J1, Q9H0Z1, Q9NTS3	Gene names	ATRX, RAD54L, XH2
Domain Architecture
Description	Transcriptional regulator ATRX (EC 3.6.1.-) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf- HX).

BPTF_HUMAN
NC score	0.023905 (rank : 1263)	θ value	0.365318 (rank : 939)
Query Neighborhood Hits	1311	Target Neighborhood Hits	786	Shared Neighborhood Hits	180
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

CN155_HUMAN
NC score	0.023881 (rank : 1264)	θ value	0.279714 (rank : 923)
Query Neighborhood Hits	1311	Target Neighborhood Hits	385	Shared Neighborhood Hits	65
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

LMNB2_HUMAN
NC score	0.023706 (rank : 1265)	θ value	8.99809 (rank : 1281)
Query Neighborhood Hits	1311	Target Neighborhood Hits	723	Shared Neighborhood Hits	186
SwissProt Accessions	Q03252, O75292, Q14734, Q96DF6	Gene names	LMNB2, LMN2
Domain Architecture
Description	Lamin-B2.

CF153_MOUSE
NC score	0.023696 (rank : 1266)	θ value	0.279714 (rank : 922)
Query Neighborhood Hits	1311	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	Q3UFY0, Q91X71	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf153 homolog.

PRP40_MOUSE
NC score	0.023666 (rank : 1267)	θ value	1.81305 (rank : 1068)
Query Neighborhood Hits	1311	Target Neighborhood Hits	447	Shared Neighborhood Hits	130
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

PRP40_HUMAN
NC score	0.023611 (rank : 1268)	θ value	2.36792 (rank : 1102)
Query Neighborhood Hits	1311	Target Neighborhood Hits	442	Shared Neighborhood Hits	137
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

VCX3_HUMAN
NC score	0.023337 (rank : 1269)	θ value	0.62314 (rank : 982)
Query Neighborhood Hits	1311	Target Neighborhood Hits	105	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NNX9, Q9P0H4	Gene names	VCX3A, VCX3, VCX8R, VCXA
Domain Architecture	No domain graphic available
Description	Variable charge X-linked protein 3 (VCX-A protein) (Variably charged protein X-A) (Variable charge protein on X with eight repeats) (VCX- 8r).

MPP10_HUMAN
NC score	0.023148 (rank : 1270)	θ value	3.0926 (rank : 1134)
Query Neighborhood Hits	1311	Target Neighborhood Hits	306	Shared Neighborhood Hits	110
SwissProt Accessions	O00566	Gene names	MPHOSPH10, MPP10
Domain Architecture
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

MYT1L_HUMAN
NC score	0.022992 (rank : 1271)	θ value	0.00869519 (rank : 834)
Query Neighborhood Hits	1311	Target Neighborhood Hits	471	Shared Neighborhood Hits	129
SwissProt Accessions	Q9UL68, Q6IQ17, Q9UPP6	Gene names	MYT1L, KIAA1106
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (MyT1-L).

CCD47_HUMAN
NC score	0.022927 (rank : 1272)	θ value	0.21417 (rank : 910)
Query Neighborhood Hits	1311	Target Neighborhood Hits	119	Shared Neighborhood Hits	65
SwissProt Accessions	Q96A33, Q96D00, Q96JZ7, Q9H3E4, Q9NRG3	Gene names	CCDC47
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 47 precursor.

GFAP_MOUSE
NC score	0.022647 (rank : 1273)	θ value	0.813845 (rank : 995)
Query Neighborhood Hits	1311	Target Neighborhood Hits	725	Shared Neighborhood Hits	199
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

NFH_HUMAN
NC score	0.022353 (rank : 1274)	θ value	0.0736092 (rank : 877)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1242	Shared Neighborhood Hits	246
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

YTDC1_HUMAN
NC score	0.022115 (rank : 1275)	θ value	1.06291 (rank : 1028)
Query Neighborhood Hits	1311	Target Neighborhood Hits	458	Shared Neighborhood Hits	136
SwissProt Accessions	Q96MU7, Q7Z622, Q8TF35	Gene names	YTHDC1, KIAA1966, YT521
Domain Architecture
Description	YTH domain-containing protein 1 (Putative splicing factor YT521).

MYT1L_MOUSE
NC score	0.022073 (rank : 1276)	θ value	0.62314 (rank : 975)
Query Neighborhood Hits	1311	Target Neighborhood Hits	461	Shared Neighborhood Hits	130
SwissProt Accessions	P97500, O08996, Q8C643, Q8C7L4, Q8CHB4	Gene names	Myt1l, Kiaa1106, Nzf1, Png1
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1-like protein (MyT1L protein) (Postmitotic neural gene 1 protein) (Zinc finger protein Png-1) (Neural zinc finger factor 1) (NZF-1).

MYST4_HUMAN
NC score	0.022067 (rank : 1277)	θ value	0.000270298 (rank : 808)
Query Neighborhood Hits	1311	Target Neighborhood Hits	671	Shared Neighborhood Hits	154
SwissProt Accessions	Q8WYB5, O15087, Q86Y05, Q8WU81, Q9UKW2, Q9UKW3, Q9UKX0	Gene names	MYST4, KIAA0383, MORF, MOZ2
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST4 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 4) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4) (Histone acetyltransferase MOZ2) (Monocytic leukemia zinc finger protein- related factor) (Histone acetyltransferase MORF).

DBNL_MOUSE
NC score	0.021676 (rank : 1278)	θ value	2.36792 (rank : 1088)
Query Neighborhood Hits	1311	Target Neighborhood Hits	306	Shared Neighborhood Hits	75
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

CF153_HUMAN
NC score	0.021571 (rank : 1279)	θ value	1.81305 (rank : 1057)
Query Neighborhood Hits	1311	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q96EU6, Q9BRF6, Q9P0C8	Gene names	C6orf153
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf153.

UBP8_HUMAN
NC score	0.021570 (rank : 1280)	θ value	0.279714 (rank : 937)
Query Neighborhood Hits	1311	Target Neighborhood Hits	751	Shared Neighborhood Hits	227
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

GBP2_HUMAN
NC score	0.021418 (rank : 1281)	θ value	0.813845 (rank : 994)
Query Neighborhood Hits	1311	Target Neighborhood Hits	349	Shared Neighborhood Hits	119
SwissProt Accessions	P32456, Q86TB0	Gene names	GBP2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (HuGBP-2).

LMNA_MOUSE
NC score	0.021345 (rank : 1282)	θ value	0.813845 (rank : 998)
Query Neighborhood Hits	1311	Target Neighborhood Hits	661	Shared Neighborhood Hits	191
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

SAKS1_MOUSE
NC score	0.021259 (rank : 1283)	θ value	8.99809 (rank : 1301)
Query Neighborhood Hits	1311	Target Neighborhood Hits	208	Shared Neighborhood Hits	73
SwissProt Accessions	Q922Y1, Q3UCP8	Gene names	Saks1, D19Ertd721e
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein) (mY33K) (Protein 2B28).

KIF14_HUMAN
NC score	0.021187 (rank : 1284)	θ value	3.0926 (rank : 1132)
Query Neighborhood Hits	1311	Target Neighborhood Hits	732	Shared Neighborhood Hits	219
SwissProt Accessions	Q15058	Gene names	KIF14, KIAA0042
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF14.

SAFB1_HUMAN
NC score	0.020963 (rank : 1285)	θ value	5.27518 (rank : 1215)
Query Neighborhood Hits	1311	Target Neighborhood Hits	493	Shared Neighborhood Hits	124
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

LMNA_HUMAN
NC score	0.020751 (rank : 1286)	θ value	1.06291 (rank : 1018)
Query Neighborhood Hits	1311	Target Neighborhood Hits	653	Shared Neighborhood Hits	189
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

ESCO1_HUMAN
NC score	0.020411 (rank : 1287)	θ value	0.163984 (rank : 902)
Query Neighborhood Hits	1311	Target Neighborhood Hits	361	Shared Neighborhood Hits	117
SwissProt Accessions	Q5FWF5, Q69YG4, Q69YS3, Q6IMD7, Q8N3Z5, Q8NBG2, Q96PX7	Gene names	ESCO1, EFO1, KIAA1911
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO1 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1) (Establishment factor- like protein 1) (EFO1p) (hEFO1) (CTF7 homolog 1).

DNMT1_HUMAN
NC score	0.020358 (rank : 1288)	θ value	6.88961 (rank : 1233)
Query Neighborhood Hits	1311	Target Neighborhood Hits	401	Shared Neighborhood Hits	121
SwissProt Accessions	P26358, Q9UHG5, Q9ULA2, Q9UMZ6	Gene names	DNMT1, AIM, DNMT
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).

ERCC5_HUMAN
NC score	0.020302 (rank : 1289)	θ value	0.00175202 (rank : 819)
Query Neighborhood Hits	1311	Target Neighborhood Hits	162	Shared Neighborhood Hits	54
SwissProt Accessions	P28715, Q7Z2V3, Q8IZL6, Q8N1B7, Q9HD59	Gene names	ERCC5, XPG, XPGC
Domain Architecture
Description	DNA-repair protein complementing XP-G cells (Xeroderma pigmentosum group G-complementing protein) (DNA excision repair protein ERCC-5).

GON4L_HUMAN
NC score	0.020092 (rank : 1290)	θ value	0.279714 (rank : 925)
Query Neighborhood Hits	1311	Target Neighborhood Hits	555	Shared Neighborhood Hits	118
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

LMNB2_MOUSE
NC score	0.020052 (rank : 1291)	θ value	4.03905 (rank : 1166)
Query Neighborhood Hits	1311	Target Neighborhood Hits	674	Shared Neighborhood Hits	181
SwissProt Accessions	P21619, P48680, Q8CGB1	Gene names	Lmnb2
Domain Architecture
Description	Lamin-B2.

ERCC5_MOUSE
NC score	0.019955 (rank : 1292)	θ value	1.81305 (rank : 1062)
Query Neighborhood Hits	1311	Target Neighborhood Hits	206	Shared Neighborhood Hits	61
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

BFSP1_HUMAN
NC score	0.019902 (rank : 1293)	θ value	2.36792 (rank : 1080)
Query Neighborhood Hits	1311	Target Neighborhood Hits	508	Shared Neighborhood Hits	144
SwissProt Accessions	Q12934, O43595, O76034, Q9HBX4	Gene names	BFSP1
Domain Architecture
Description	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H).

FILA_HUMAN
NC score	0.019344 (rank : 1294)	θ value	1.06291 (rank : 1015)
Query Neighborhood Hits	1311	Target Neighborhood Hits	685	Shared Neighborhood Hits	106
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

BTBDC_HUMAN
NC score	0.019326 (rank : 1295)	θ value	1.38821 (rank : 1035)
Query Neighborhood Hits	1311	Target Neighborhood Hits	248	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

BRD4_HUMAN
NC score	0.019321 (rank : 1296)	θ value	0.47712 (rank : 955)
Query Neighborhood Hits	1311	Target Neighborhood Hits	851	Shared Neighborhood Hits	170
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

MYT1_HUMAN
NC score	0.019253 (rank : 1297)	θ value	0.365318 (rank : 946)
Query Neighborhood Hits	1311	Target Neighborhood Hits	475	Shared Neighborhood Hits	138
SwissProt Accessions	Q01538, O94922, Q9UPV2	Gene names	MYT1, KIAA0835, KIAA1050, MTF1, MYTI, PLPB1
Domain Architecture
Description	Myelin transcription factor 1 (MyT1) (MyTI) (Proteolipid protein- binding protein) (PLPB1).

MYO7A_HUMAN
NC score	0.019204 (rank : 1298)	θ value	0.0736092 (rank : 876)
Query Neighborhood Hits	1311	Target Neighborhood Hits	209	Shared Neighborhood Hits	61
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

RIF1_HUMAN
NC score	0.019088 (rank : 1299)	θ value	1.06291 (rank : 1023)
Query Neighborhood Hits	1311	Target Neighborhood Hits	320	Shared Neighborhood Hits	105
SwissProt Accessions	Q5UIP0, Q5H9R3, Q5UIP2, Q66YK6, Q6PRU2, Q8TE94, Q99772, Q9H830, Q9H9B9, Q9NVP5, Q9Y4R4	Gene names	RIF1
Domain Architecture	No domain graphic available
Description	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog).

NONO_MOUSE
NC score	0.019047 (rank : 1300)	θ value	0.365318 (rank : 947)
Query Neighborhood Hits	1311	Target Neighborhood Hits	444	Shared Neighborhood Hits	100
SwissProt Accessions	Q99K48, Q63887, Q9CYQ4, Q9DBP2	Gene names	Nono
Domain Architecture	No domain graphic available
Description	Non-POU domain-containing octamer-binding protein (NonO protein).

DAXX_HUMAN
NC score	0.018768 (rank : 1301)	θ value	0.813845 (rank : 992)
Query Neighborhood Hits	1311	Target Neighborhood Hits	207	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UER7, O14747, O15141, O15208, Q9BWI3	Gene names	DAXX, BING2, DAP6
Domain Architecture
Description	Death domain-associated protein 6 (Daxx) (hDaxx) (Fas death domain- associated protein) (ETS1-associated protein 1) (EAP1).

BAZ2A_MOUSE
NC score	0.018240 (rank : 1302)	θ value	1.38821 (rank : 1032)
Query Neighborhood Hits	1311	Target Neighborhood Hits	744	Shared Neighborhood Hits	133
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

NONO_HUMAN
NC score	0.018219 (rank : 1303)	θ value	1.38821 (rank : 1044)
Query Neighborhood Hits	1311	Target Neighborhood Hits	441	Shared Neighborhood Hits	100
SwissProt Accessions	Q15233, O00201, P30807, Q12786, Q9BQC5	Gene names	NONO, NRB54
Domain Architecture
Description	Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit).

CE110_HUMAN
NC score	0.018147 (rank : 1304)	θ value	2.36792 (rank : 1085)
Query Neighborhood Hits	1311	Target Neighborhood Hits	197	Shared Neighborhood Hits	59
SwissProt Accessions	O43303, O43335, Q68DV9, Q8NE13	Gene names	CEP110, CP110, KIAA0419
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 110 kDa (Cep110 protein).

APLP2_MOUSE
NC score	0.018134 (rank : 1305)	θ value	4.03905 (rank : 1157)
Query Neighborhood Hits	1311	Target Neighborhood Hits	186	Shared Neighborhood Hits	80
SwissProt Accessions	Q06335	Gene names	Aplp2
Domain Architecture
Description	Amyloid-like protein 2 precursor (CDEI box-binding protein) (CDEBP).

BRD4_MOUSE
NC score	0.018089 (rank : 1306)	θ value	3.0926 (rank : 1118)
Query Neighborhood Hits	1311	Target Neighborhood Hits	845	Shared Neighborhood Hits	180
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

RUSC1_HUMAN
NC score	0.017954 (rank : 1307)	θ value	2.36792 (rank : 1106)
Query Neighborhood Hits	1311	Target Neighborhood Hits	226	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

CUTL2_MOUSE
NC score	0.017908 (rank : 1308)	θ value	0.279714 (rank : 924)
Query Neighborhood Hits	1311	Target Neighborhood Hits	771	Shared Neighborhood Hits	156
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

SPTN5_HUMAN
NC score	0.017756 (rank : 1309)	θ value	4.03905 (rank : 1180)
Query Neighborhood Hits	1311	Target Neighborhood Hits	674	Shared Neighborhood Hits	159
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

PTMA_HUMAN
NC score	0.017567 (rank : 1310)	θ value	8.99809 (rank : 1297)
Query Neighborhood Hits	1311	Target Neighborhood Hits	88	Shared Neighborhood Hits	25
SwissProt Accessions	P06454, Q15249, Q15592	Gene names	PTMA, TMSA
Domain Architecture	No domain graphic available
Description	Prothymosin alpha [Contains: Thymosin alpha-1].

NOLC1_HUMAN
NC score	0.017462 (rank : 1311)	θ value	4.03905 (rank : 1169)
Query Neighborhood Hits	1311	Target Neighborhood Hits	452	Shared Neighborhood Hits	74
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NCOR1_MOUSE
NC score	0.016743 (rank : 1312)	θ value	2.36792 (rank : 1096)
Query Neighborhood Hits	1311	Target Neighborhood Hits	521	Shared Neighborhood Hits	121
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

SAKS1_HUMAN
NC score	0.016500 (rank : 1313)	θ value	6.88961 (rank : 1250)
Query Neighborhood Hits	1311	Target Neighborhood Hits	202	Shared Neighborhood Hits	69
SwissProt Accessions	Q04323, Q9BV93, Q9BVV5	Gene names	SAKS1
Domain Architecture
Description	SAPK substrate protein 1 (UBA/UBX 33.3 kDa protein).

ENL_HUMAN
NC score	0.016442 (rank : 1314)	θ value	1.06291 (rank : 1012)
Query Neighborhood Hits	1311	Target Neighborhood Hits	305	Shared Neighborhood Hits	46
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

TF2AY_HUMAN
NC score	0.016240 (rank : 1315)	θ value	3.0926 (rank : 1150)
Query Neighborhood Hits	1311	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UNN4	Gene names	GTF2A1LF, ALF
Domain Architecture
Description	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor).

DHX16_HUMAN
NC score	0.016213 (rank : 1316)	θ value	1.81305 (rank : 1058)
Query Neighborhood Hits	1311	Target Neighborhood Hits	356	Shared Neighborhood Hits	130
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

SON_MOUSE
NC score	0.016053 (rank : 1317)	θ value	1.38821 (rank : 1048)
Query Neighborhood Hits	1311	Target Neighborhood Hits	957	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

KI21B_HUMAN
NC score	0.016031 (rank : 1318)	θ value	1.81305 (rank : 1065)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1017	Shared Neighborhood Hits	198
SwissProt Accessions	O75037, Q5T4J3	Gene names	KIF21B, KIAA0449
Domain Architecture	No domain graphic available
Description	Kinesin family member 21B.

ULE1B_MOUSE
NC score	0.015897 (rank : 1319)	θ value	0.0563607 (rank : 872)
Query Neighborhood Hits	1311	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1F9, Q8BVX9	Gene names	Uble1b, Sae2, Uba2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

UBF1_MOUSE
NC score	0.015665 (rank : 1320)	θ value	8.99809 (rank : 1309)
Query Neighborhood Hits	1311	Target Neighborhood Hits	419	Shared Neighborhood Hits	118
SwissProt Accessions	P25976	Gene names	Ubtf, Tcfubf, Ubf-1, Ubf1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1).

ST18_MOUSE
NC score	0.015639 (rank : 1321)	θ value	8.99809 (rank : 1305)
Query Neighborhood Hits	1311	Target Neighborhood Hits	248	Shared Neighborhood Hits	71
SwissProt Accessions	Q80TY4, Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q811B4, Q8K098	Gene names	St18, Kiaa0535
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18.

DAAM1_HUMAN
NC score	0.015466 (rank : 1322)	θ value	8.99809 (rank : 1269)
Query Neighborhood Hits	1311	Target Neighborhood Hits	483	Shared Neighborhood Hits	131
SwissProt Accessions	Q9Y4D1, Q86U34, Q8N1Z8, Q8TB39	Gene names	DAAM1, KIAA0666
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

MYT1_MOUSE
NC score	0.015248 (rank : 1323)	θ value	0.62314 (rank : 976)
Query Neighborhood Hits	1311	Target Neighborhood Hits	385	Shared Neighborhood Hits	93
SwissProt Accessions	Q8CFC2, O08995, Q8CFH1	Gene names	Myt1, Kiaa0835, Nzf2
Domain Architecture	No domain graphic available
Description	Myelin transcription factor 1 (MyT1) (Neural zinc finger factor 2) (NZF-2).

N4BP3_HUMAN
NC score	0.015074 (rank : 1324)	θ value	5.27518 (rank : 1209)
Query Neighborhood Hits	1311	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	O15049, Q7Z6I3	Gene names	N4BP3, KIAA0341
Domain Architecture
Description	NEDD4-binding protein 3 (N4BP3).

RXINP_HUMAN
NC score	0.014917 (rank : 1325)	θ value	1.81305 (rank : 1071)
Query Neighborhood Hits	1311	Target Neighborhood Hits	87	Shared Neighborhood Hits	36
SwissProt Accessions	Q96RL1, Q5XKQ1, Q7Z3W7, Q8N5B9, Q9BZR1, Q9BZR5, Q9UHX7	Gene names	RXRIP110, RAP80
Domain Architecture	No domain graphic available
Description	Retinoid X receptor-interacting protein 110 (Receptor-associated protein 80) (Nuclear zinc finger protein RAP80).

MYST3_HUMAN
NC score	0.014650 (rank : 1326)	θ value	0.279714 (rank : 930)
Query Neighborhood Hits	1311	Target Neighborhood Hits	772	Shared Neighborhood Hits	148
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

HDAC5_HUMAN
NC score	0.014527 (rank : 1327)	θ value	3.0926 (rank : 1130)
Query Neighborhood Hits	1311	Target Neighborhood Hits	353	Shared Neighborhood Hits	111
SwissProt Accessions	Q9UQL6, O60340, O60528, Q96DY4	Gene names	HDAC5, KIAA0600
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Antigen NY-CO-9).

NRDC_MOUSE
NC score	0.014500 (rank : 1328)	θ value	0.0148317 (rank : 842)
Query Neighborhood Hits	1311	Target Neighborhood Hits	96	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BHG1	Gene names	Nrd1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

NRDC_HUMAN
NC score	0.014112 (rank : 1329)	θ value	0.0148317 (rank : 841)
Query Neighborhood Hits	1311	Target Neighborhood Hits	60	Shared Neighborhood Hits	15
SwissProt Accessions	O43847, O15241, O15242, Q5VUL0, Q96HB2, Q9NU57	Gene names	NRD1
Domain Architecture
Description	Nardilysin precursor (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C).

SET1A_HUMAN
NC score	0.013874 (rank : 1330)	θ value	4.03905 (rank : 1178)
Query Neighborhood Hits	1311	Target Neighborhood Hits	690	Shared Neighborhood Hits	101
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

ATX3_HUMAN
NC score	0.013784 (rank : 1331)	θ value	6.88961 (rank : 1227)
Query Neighborhood Hits	1311	Target Neighborhood Hits	117	Shared Neighborhood Hits	45
SwissProt Accessions	P54252, O15284, O15285, O15286, Q8N189, Q96TC3, Q96TC4, Q9H3N0	Gene names	ATXN3, ATX3, MJD, MJD1, SCA3
Domain Architecture
Description	Ataxin-3 (EC 3.4.22.-) (Machado-Joseph disease protein 1) (Spinocerebellar ataxia type 3 protein).

BRD3_MOUSE
NC score	0.013284 (rank : 1332)	θ value	5.27518 (rank : 1188)
Query Neighborhood Hits	1311	Target Neighborhood Hits	402	Shared Neighborhood Hits	117
SwissProt Accessions	Q8K2F0, Q8C665, Q8CAX7, Q9JI25	Gene names	Brd3, Fsrg2
Domain Architecture
Description	Bromodomain-containing protein 3 (Bromodomain-containing FSH-like protein FSRG2).

NFL_HUMAN
NC score	0.013242 (rank : 1333)	θ value	0.279714 (rank : 931)
Query Neighborhood Hits	1311	Target Neighborhood Hits	666	Shared Neighborhood Hits	176
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

MYST3_MOUSE
NC score	0.013207 (rank : 1334)	θ value	0.125558 (rank : 894)
Query Neighborhood Hits	1311	Target Neighborhood Hits	688	Shared Neighborhood Hits	161
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

GON4L_MOUSE
NC score	0.013181 (rank : 1335)	θ value	0.62314 (rank : 974)
Query Neighborhood Hits	1311	Target Neighborhood Hits	455	Shared Neighborhood Hits	86
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

CEND3_HUMAN
NC score	0.013174 (rank : 1336)	θ value	0.21417 (rank : 911)
Query Neighborhood Hits	1311	Target Neighborhood Hits	275	Shared Neighborhood Hits	44
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

NFL_MOUSE
NC score	0.013133 (rank : 1337)	θ value	2.36792 (rank : 1099)
Query Neighborhood Hits	1311	Target Neighborhood Hits	695	Shared Neighborhood Hits	187
SwissProt Accessions	P08551, Q8K0Z0	Gene names	Nefl, Nf68, Nfl
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

UT14B_MOUSE
NC score	0.013099 (rank : 1338)	θ value	0.62314 (rank : 981)
Query Neighborhood Hits	1311	Target Neighborhood Hits	226	Shared Neighborhood Hits	96
SwissProt Accessions	Q6EJB6, Q6EJB5, Q8BL60	Gene names	Utp14b, Jsd
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog B (Juvenile spermatogonial depletion protein).

PDXL2_MOUSE
NC score	0.012867 (rank : 1339)	θ value	3.0926 (rank : 1137)
Query Neighborhood Hits	1311	Target Neighborhood Hits	213	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CAE9, Q8CFW3	Gene names	Podxl2
Domain Architecture	No domain graphic available
Description	Podocalyxin-like protein 2 precursor (Endoglycan).

APLP2_HUMAN
NC score	0.012785 (rank : 1340)	θ value	5.27518 (rank : 1186)
Query Neighborhood Hits	1311	Target Neighborhood Hits	193	Shared Neighborhood Hits	77
SwissProt Accessions	Q06481	Gene names	APLP2, APPL2
Domain Architecture
Description	Amyloid-like protein 2 precursor (Amyloid protein homolog) (APPH) (CDEI box-binding protein) (CDEBP).

UBF1_HUMAN
NC score	0.012624 (rank : 1341)	θ value	4.03905 (rank : 1185)
Query Neighborhood Hits	1311	Target Neighborhood Hits	415	Shared Neighborhood Hits	103
SwissProt Accessions	P17480	Gene names	UBTF, UBF, UBF1
Domain Architecture
Description	Nucleolar transcription factor 1 (Upstream-binding factor 1) (UBF-1) (Autoantigen NOR-90).

LAMB1_HUMAN
NC score	0.012454 (rank : 1342)	θ value	3.0926 (rank : 1133)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1018	Shared Neighborhood Hits	191
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

FEZ1_HUMAN
NC score	0.012322 (rank : 1343)	θ value	0.62314 (rank : 973)
Query Neighborhood Hits	1311	Target Neighborhood Hits	120	Shared Neighborhood Hits	45
SwissProt Accessions	Q99689, O00679, O00728, Q6IBI7	Gene names	FEZ1
Domain Architecture	No domain graphic available
Description	Fasciculation and elongation protein zeta 1 (Zygin-1) (Zygin I).

AP3D1_HUMAN
NC score	0.012099 (rank : 1344)	θ value	0.365318 (rank : 938)
Query Neighborhood Hits	1311	Target Neighborhood Hits	254	Shared Neighborhood Hits	59
SwissProt Accessions	O14617, O00202, O75262, Q59HF5, Q96G11, Q9H3C6	Gene names	AP3D1
Domain Architecture
Description	AP-3 complex subunit delta-1 (Adapter-related protein complex 3 subunit delta-1) (Delta-adaptin 3) (AP-3 complex subunit delta) (Delta-adaptin).

AFF1_MOUSE
NC score	0.012029 (rank : 1345)	θ value	1.81305 (rank : 1051)
Query Neighborhood Hits	1311	Target Neighborhood Hits	351	Shared Neighborhood Hits	54
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

ZBED3_HUMAN
NC score	0.012008 (rank : 1346)	θ value	6.88961 (rank : 1257)
Query Neighborhood Hits	1311	Target Neighborhood Hits	50	Shared Neighborhood Hits	21
SwissProt Accessions	Q96IU2	Gene names	ZBED3
Domain Architecture
Description	Zinc finger BED domain-containing protein 3.

RN168_MOUSE
NC score	0.011701 (rank : 1347)	θ value	2.36792 (rank : 1105)
Query Neighborhood Hits	1311	Target Neighborhood Hits	440	Shared Neighborhood Hits	91
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TUR8_MOUSE
NC score	0.011381 (rank : 1348)	θ value	1.81305 (rank : 1074)
Query Neighborhood Hits	1311	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	P19473	Gene names	Trap1a, P1a
Domain Architecture	No domain graphic available
Description	Tumor rejection antigen P815A.

FEZ1_MOUSE
NC score	0.011284 (rank : 1349)	θ value	1.06291 (rank : 1014)
Query Neighborhood Hits	1311	Target Neighborhood Hits	93	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K0X8	Gene names	Fez1
Domain Architecture	No domain graphic available
Description	Fasciculation and elongation protein zeta 1 (Zygin-1) (Zygin I).

CT077_HUMAN
NC score	0.010995 (rank : 1350)	θ value	2.36792 (rank : 1087)
Query Neighborhood Hits	1311	Target Neighborhood Hits	155	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NQG5	Gene names	C20orf77
Domain Architecture
Description	Uncharacterized protein C20orf77.

ULE1B_HUMAN
NC score	0.010954 (rank : 1351)	θ value	0.0431538 (rank : 862)
Query Neighborhood Hits	1311	Target Neighborhood Hits	31	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBT2, O95605, Q9NTJ1, Q9UED2	Gene names	UBLE1B, SAE2, UBA2
Domain Architecture
Description	Ubiquitin-like 1-activating enzyme E1B (SUMO-1-activating enzyme subunit 2) (Anthracycline-associated resistance ARX).

RFIP1_HUMAN
NC score	0.010830 (rank : 1352)	θ value	0.365318 (rank : 948)
Query Neighborhood Hits	1311	Target Neighborhood Hits	236	Shared Neighborhood Hits	37
SwissProt Accessions	Q6WKZ4, Q6AZK4, Q6WKZ2, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642	Gene names	RAB11FIP1, RCP
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

NARGL_HUMAN
NC score	0.010759 (rank : 1353)	θ value	8.99809 (rank : 1287)
Query Neighborhood Hits	1311	Target Neighborhood Hits	222	Shared Neighborhood Hits	70
SwissProt Accessions	Q6N069, Q5VSP9, Q6P2D5, Q8N5J3, Q8N870	Gene names	NARG1L, NAT2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

ALMS1_HUMAN
NC score	0.010742 (rank : 1354)	θ value	2.36792 (rank : 1078)
Query Neighborhood Hits	1311	Target Neighborhood Hits	356	Shared Neighborhood Hits	69
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

CENPB_HUMAN
NC score	0.010605 (rank : 1355)	θ value	0.62314 (rank : 969)
Query Neighborhood Hits	1311	Target Neighborhood Hits	133	Shared Neighborhood Hits	36
SwissProt Accessions	P07199	Gene names	CENPB
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

EP300_HUMAN
NC score	0.010444 (rank : 1356)	θ value	2.36792 (rank : 1089)
Query Neighborhood Hits	1311	Target Neighborhood Hits	821	Shared Neighborhood Hits	99
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

SPTN4_HUMAN
NC score	0.010382 (rank : 1357)	θ value	0.365318 (rank : 951)
Query Neighborhood Hits	1311	Target Neighborhood Hits	570	Shared Neighborhood Hits	137
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

ANK1_MOUSE
NC score	0.010310 (rank : 1358)	θ value	8.99809 (rank : 1260)
Query Neighborhood Hits	1311	Target Neighborhood Hits	430	Shared Neighborhood Hits	60
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

BAT2_MOUSE
NC score	0.010299 (rank : 1359)	θ value	6.88961 (rank : 1229)
Query Neighborhood Hits	1311	Target Neighborhood Hits	947	Shared Neighborhood Hits	102
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

RERE_HUMAN
NC score	0.010239 (rank : 1360)	θ value	8.99809 (rank : 1298)
Query Neighborhood Hits	1311	Target Neighborhood Hits	779	Shared Neighborhood Hits	101
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

HDAC5_MOUSE
NC score	0.010224 (rank : 1361)	θ value	5.27518 (rank : 1203)
Query Neighborhood Hits	1311	Target Neighborhood Hits	310	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Z2V6, Q9JL73	Gene names	Hdac5
Domain Architecture
Description	Histone deacetylase 5 (HD5) (Histone deacetylase mHDA1).

STABP_HUMAN
NC score	0.010176 (rank : 1362)	θ value	6.88961 (rank : 1255)
Query Neighborhood Hits	1311	Target Neighborhood Hits	140	Shared Neighborhood Hits	51
SwissProt Accessions	O95630, Q3MJE7	Gene names	STAMBP, AMSH
Domain Architecture	No domain graphic available
Description	STAM-binding protein (EC 3.1.2.15) (Associated molecule with the SH3 domain of STAM).

CEND3_MOUSE
NC score	0.010049 (rank : 1363)	θ value	8.99809 (rank : 1264)
Query Neighborhood Hits	1311	Target Neighborhood Hits	228	Shared Neighborhood Hits	35
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

TF2AY_MOUSE
NC score	0.009930 (rank : 1364)	θ value	4.03905 (rank : 1184)
Query Neighborhood Hits	1311	Target Neighborhood Hits	51	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R4I4, Q99PM2, Q9DAF4	Gene names	Gtf2a1lf, Alf
Domain Architecture
Description	TFIIA-alpha and beta-like factor (General transcription factor II A, 1-like factor).

AN32B_MOUSE
NC score	0.009838 (rank : 1365)	θ value	0.0961366 (rank : 878)
Query Neighborhood Hits	1311	Target Neighborhood Hits	236	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EST5	Gene names	Anp32b, Pal31
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (Proliferation-related acidic leucine-rich protein PAL31).

CENPB_MOUSE
NC score	0.009803 (rank : 1366)	θ value	0.813845 (rank : 990)
Query Neighborhood Hits	1311	Target Neighborhood Hits	163	Shared Neighborhood Hits	38
SwissProt Accessions	P27790	Gene names	Cenpb, Cenp-b
Domain Architecture
Description	Major centromere autoantigen B (Centromere protein B) (CENP-B).

TCAL3_MOUSE
NC score	0.009638 (rank : 1367)	θ value	2.36792 (rank : 1110)
Query Neighborhood Hits	1311	Target Neighborhood Hits	132	Shared Neighborhood Hits	36
SwissProt Accessions	Q8R0A5, Q9CYK5, Q9D1S4	Gene names	Tceal3
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 3 (TCEA-like protein 3) (Transcription elongation factor S-II protein-like 3).

T2FA_HUMAN
NC score	0.009577 (rank : 1368)	θ value	4.03905 (rank : 1182)
Query Neighborhood Hits	1311	Target Neighborhood Hits	228	Shared Neighborhood Hits	54
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

SNUT1_HUMAN
NC score	0.009497 (rank : 1369)	θ value	0.62314 (rank : 979)
Query Neighborhood Hits	1311	Target Neighborhood Hits	129	Shared Neighborhood Hits	38
SwissProt Accessions	O43290, Q53GB5	Gene names	SART1
Domain Architecture	No domain graphic available
Description	U4/U6.U5 tri-snRNP-associated protein 1 (U4/U6.U5 tri-snRNP-associated 110 kDa protein) (Squamous cell carcinoma antigen recognized by T cells 1) (SART-1) (hSART-1) (hSnu66).

ICAL_HUMAN
NC score	0.009447 (rank : 1370)	θ value	4.03905 (rank : 1162)
Query Neighborhood Hits	1311	Target Neighborhood Hits	275	Shared Neighborhood Hits	67
SwissProt Accessions	P20810, O95360, Q96D08, Q9H1Z5	Gene names	CAST
Domain Architecture
Description	Calpastatin (Calpain inhibitor) (Sperm BS-17 component).

LIGA_HUMAN
NC score	0.009408 (rank : 1371)	θ value	1.38821 (rank : 1043)
Query Neighborhood Hits	1311	Target Neighborhood Hits	23	Shared Neighborhood Hits	7
SwissProt Accessions	P41214, Q9NR27, Q9NSN0, Q9NV18, Q9NZ21	Gene names	LGTN, HCA56
Domain Architecture
Description	Ligatin (Hepatocellular carcinoma-associated antigen 56).

DAXX_MOUSE
NC score	0.009076 (rank : 1372)	θ value	6.88961 (rank : 1232)
Query Neighborhood Hits	1311	Target Neighborhood Hits	173	Shared Neighborhood Hits	38
SwissProt Accessions	O35613, Q9QWT8, Q9QWV3	Gene names	Daxx
Domain Architecture
Description	Death domain-associated protein 6 (Daxx).

E41L2_MOUSE
NC score	0.009009 (rank : 1373)	θ value	1.38821 (rank : 1038)
Query Neighborhood Hits	1311	Target Neighborhood Hits	459	Shared Neighborhood Hits	181
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

NADAP_HUMAN
NC score	0.008985 (rank : 1374)	θ value	1.06291 (rank : 1020)
Query Neighborhood Hits	1311	Target Neighborhood Hits	208	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BWU0, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9NVN2	Gene names	SLC4A1AP, HLC3
Domain Architecture	No domain graphic available
Description	Kanadaptin (Kidney anion exchanger adapter protein) (Solute carrier family 4 anion exchanger member 1 adapter protein) (Lung cancer oncogene 3 protein).

RERE_MOUSE
NC score	0.008468 (rank : 1375)	θ value	8.99809 (rank : 1299)
Query Neighborhood Hits	1311	Target Neighborhood Hits	785	Shared Neighborhood Hits	97
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RXINP_MOUSE
NC score	0.008293 (rank : 1376)	θ value	2.36792 (rank : 1107)
Query Neighborhood Hits	1311	Target Neighborhood Hits	99	Shared Neighborhood Hits	31
SwissProt Accessions	Q5U5Q9, Q60811	Gene names	Rxrip110, Rip110
Domain Architecture	No domain graphic available
Description	Retinoid X receptor-interacting protein 110.

NOP56_MOUSE
NC score	0.007894 (rank : 1377)	θ value	2.36792 (rank : 1100)
Query Neighborhood Hits	1311	Target Neighborhood Hits	129	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D6Z1, Q3UD45, Q8BVL1, Q8VDT2, Q99LT8, Q9CT15	Gene names	Nol5a, Nop56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

TRI44_HUMAN
NC score	0.007689 (rank : 1378)	θ value	0.21417 (rank : 917)
Query Neighborhood Hits	1311	Target Neighborhood Hits	393	Shared Neighborhood Hits	88
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

SPT6H_HUMAN
NC score	0.007673 (rank : 1379)	θ value	1.81305 (rank : 1072)
Query Neighborhood Hits	1311	Target Neighborhood Hits	104	Shared Neighborhood Hits	30
SwissProt Accessions	Q7KZ85, Q15737, Q6GMQ4, Q7KYW9, Q7LDK4, Q8N526, Q92775, Q96AH3, Q9BTH9, Q9BTI2	Gene names	SUPT6H, KIAA0162, SPT6H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT6 (hSPT6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein).

SIAL_HUMAN
NC score	0.007666 (rank : 1380)	θ value	1.38821 (rank : 1047)
Query Neighborhood Hits	1311	Target Neighborhood Hits	77	Shared Neighborhood Hits	17
SwissProt Accessions	P21815	Gene names	IBSP, BNSP
Domain Architecture
Description	Bone sialoprotein-2 precursor (Bone sialoprotein II) (BSP II) (Cell- binding sialoprotein) (Integrin-binding sialoprotein).

WRN_MOUSE
NC score	0.007515 (rank : 1381)	θ value	3.0926 (rank : 1153)
Query Neighborhood Hits	1311	Target Neighborhood Hits	295	Shared Neighborhood Hits	85
SwissProt Accessions	O09053, O09050, Q9JKD4, Q9Z241, Q9Z242	Gene names	Wrn
Domain Architecture
Description	Werner syndrome ATP-dependent helicase homolog (EC 3.6.1.-).

SENP7_HUMAN
NC score	0.007362 (rank : 1382)	θ value	8.99809 (rank : 1302)
Query Neighborhood Hits	1311	Target Neighborhood Hits	97	Shared Neighborhood Hits	29
SwissProt Accessions	Q9BQF6, Q96PS5, Q9C0F6, Q9HBT5	Gene names	SENP7, KIAA1707, SSP2, SUSP2
Domain Architecture
Description	Sentrin-specific protease 7 (EC 3.4.22.-) (Sentrin/SUMO-specific protease SENP7) (SUMO-1-specific protease 2).

SPT16_HUMAN
NC score	0.007322 (rank : 1383)	θ value	5.27518 (rank : 1218)
Query Neighborhood Hits	1311	Target Neighborhood Hits	100	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5B9, Q6GMT8, Q6P2F1, Q6PJM1, Q9NRX0	Gene names	SUPT16H, FACT140, FACTP140
Domain Architecture	No domain graphic available
Description	FACT complex subunit SPT16 (Facilitates chromatin transcription complex subunit SPT16) (hSPT16) (FACT 140 kDa subunit) (FACTp140) (Chromatin-specific transcription elongation factor 140 kDa subunit).

CJ006_MOUSE
NC score	0.006993 (rank : 1384)	θ value	3.0926 (rank : 1120)
Query Neighborhood Hits	1311	Target Neighborhood Hits	141	Shared Neighborhood Hits	33
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

SPT16_MOUSE
NC score	0.006554 (rank : 1385)	θ value	5.27518 (rank : 1219)
Query Neighborhood Hits	1311	Target Neighborhood Hits	91	Shared Neighborhood Hits	35
SwissProt Accessions	Q920B9, Q3TZ48, Q3UFH0, Q921H4	Gene names	Supt16h, Fact140, Factp140
Domain Architecture	No domain graphic available
Description	FACT complex subunit SPT16 (Facilitates chromatin transcription complex subunit SPT16) (FACT 140 kDa subunit) (FACTp140) (Chromatin- specific transcription elongation factor 140 kDa subunit).

EHMT2_HUMAN
NC score	0.006549 (rank : 1386)	θ value	0.813845 (rank : 993)
Query Neighborhood Hits	1311	Target Neighborhood Hits	498	Shared Neighborhood Hits	58
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

NARGL_MOUSE
NC score	0.006547 (rank : 1387)	θ value	8.99809 (rank : 1288)
Query Neighborhood Hits	1311	Target Neighborhood Hits	175	Shared Neighborhood Hits	51
SwissProt Accessions	Q9DBB4, Q3U7V2	Gene names	Narg1l, Nat2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

SMCE1_HUMAN
NC score	0.006463 (rank : 1388)	θ value	3.0926 (rank : 1145)
Query Neighborhood Hits	1311	Target Neighborhood Hits	272	Shared Neighborhood Hits	74
SwissProt Accessions	Q969G3, O43539	Gene names	SMARCE1, BAF57
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (BRG1-associated factor 57).

EHMT2_MOUSE
NC score	0.006450 (rank : 1389)	θ value	8.99809 (rank : 1272)
Query Neighborhood Hits	1311	Target Neighborhood Hits	750	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

CDN1C_MOUSE
NC score	0.006420 (rank : 1390)	θ value	2.36792 (rank : 1084)
Query Neighborhood Hits	1311	Target Neighborhood Hits	161	Shared Neighborhood Hits	35
SwissProt Accessions	P49919	Gene names	Cdkn1c, Kip2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57KIP2).

TCAL5_MOUSE
NC score	0.006402 (rank : 1391)	θ value	3.0926 (rank : 1148)
Query Neighborhood Hits	1311	Target Neighborhood Hits	63	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CCT4, Q497R6	Gene names	Tceal5
Domain Architecture	No domain graphic available
Description	Transcription elongation factor A protein-like 5 (TCEA-like protein 5) (Transcription elongation factor S-II protein-like 5).

AN32B_HUMAN
NC score	0.006336 (rank : 1392)	θ value	0.62314 (rank : 968)
Query Neighborhood Hits	1311	Target Neighborhood Hits	243	Shared Neighborhood Hits	32
SwissProt Accessions	Q92688, O00655, P78458, P78459	Gene names	ANP32B, APRIL, PHAPI2
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines).

LAMB1_MOUSE
NC score	0.006268 (rank : 1393)	θ value	8.99809 (rank : 1280)
Query Neighborhood Hits	1311	Target Neighborhood Hits	919	Shared Neighborhood Hits	154
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

TF2AA_HUMAN
NC score	0.006151 (rank : 1394)	θ value	4.03905 (rank : 1183)
Query Neighborhood Hits	1311	Target Neighborhood Hits	35	Shared Neighborhood Hits	15
SwissProt Accessions	P52655	Gene names	GTF2A1, TF2A1
Domain Architecture
Description	Transcription initiation factor IIA subunit 1 (General transcription factor IIA1) (TFIIA-42) (TFIIAL) [Contains: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)].

AATF_MOUSE
NC score	0.006105 (rank : 1395)	θ value	3.0926 (rank : 1116)
Query Neighborhood Hits	1311	Target Neighborhood Hits	50	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JKX4, Q7TQN1, Q8C5Q2, Q99P89	Gene names	Aatf, Che1, Trb
Domain Architecture	No domain graphic available
Description	Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1) (Traube protein).

RYR1_HUMAN
NC score	0.006041 (rank : 1396)	θ value	2.36792 (rank : 1108)
Query Neighborhood Hits	1311	Target Neighborhood Hits	303	Shared Neighborhood Hits	58
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

ST65G_MOUSE
NC score	0.005948 (rank : 1397)	θ value	2.36792 (rank : 1109)
Query Neighborhood Hits	1311	Target Neighborhood Hits	23	Shared Neighborhood Hits	7
SwissProt Accessions	Q9CZV5	Gene names	Supt7l
Domain Architecture
Description	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like).

SPT5H_MOUSE
NC score	0.005875 (rank : 1398)	θ value	5.27518 (rank : 1220)
Query Neighborhood Hits	1311	Target Neighborhood Hits	437	Shared Neighborhood Hits	62
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

TRM6_MOUSE
NC score	0.005732 (rank : 1399)	θ value	2.36792 (rank : 1114)
Query Neighborhood Hits	1311	Target Neighborhood Hits	39	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CE96, Q3TJZ8, Q3TME7, Q6ZPW8, Q80Y59, Q8CEU0	Gene names	Trm6, Kiaa1153
Domain Architecture	No domain graphic available
Description	tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6 (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6).

K0562_HUMAN
NC score	0.005519 (rank : 1400)	θ value	5.27518 (rank : 1205)
Query Neighborhood Hits	1311	Target Neighborhood Hits	146	Shared Neighborhood Hits	42
SwissProt Accessions	O60308, Q5JSQ3, Q5SR24, Q5SR25, Q6PKF5, Q86W32, Q86X14	Gene names	KIAA0562
Domain Architecture	No domain graphic available
Description	Protein KIAA0562.

SRCA_HUMAN
NC score	0.005391 (rank : 1401)	θ value	6.88961 (rank : 1254)
Query Neighborhood Hits	1311	Target Neighborhood Hits	380	Shared Neighborhood Hits	73
SwissProt Accessions	Q86TD4	Gene names	SRL
Domain Architecture	No domain graphic available
Description	Sarcalumenin precursor.

ST65G_HUMAN
NC score	0.005298 (rank : 1402)	θ value	4.03905 (rank : 1181)
Query Neighborhood Hits	1311	Target Neighborhood Hits	18	Shared Neighborhood Hits	5
SwissProt Accessions	O94864, Q6IB21, Q9H2T6	Gene names	SUPT7L, KIAA0764
Domain Architecture
Description	STAGA complex 65 subunit gamma (STAF65gamma) (SPTF-associated factor 65 gamma) (Suppressor of Ty 7-like) (Adenocarcinoma antigen ART1).

UBP37_HUMAN
NC score	0.005184 (rank : 1403)	θ value	0.00390308 (rank : 826)
Query Neighborhood Hits	1311	Target Neighborhood Hits	208	Shared Neighborhood Hits	52
SwissProt Accessions	Q86T82, Q9HCH8	Gene names	USP37, KIAA1594
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 37 (EC 3.1.2.15) (Ubiquitin thioesterase 37) (Ubiquitin-specific-processing protease 37) (Deubiquitinating enzyme 37).

DISC1_MOUSE
NC score	0.004967 (rank : 1404)	θ value	1.81305 (rank : 1059)
Query Neighborhood Hits	1311	Target Neighborhood Hits	133	Shared Neighborhood Hits	32
SwissProt Accessions	Q811T9, Q7TQ21, Q8CF87, Q8CF88, Q8CHP1, Q8CHP2	Gene names	Disc1
Domain Architecture	No domain graphic available
Description	Disrupted in schizophrenia 1 homolog.

FOSB_MOUSE
NC score	0.004894 (rank : 1405)	θ value	3.0926 (rank : 1128)
Query Neighborhood Hits	1311	Target Neighborhood Hits	137	Shared Neighborhood Hits	39
SwissProt Accessions	P13346	Gene names	Fosb
Domain Architecture	No domain graphic available
Description	Protein fosB.

NOC2L_MOUSE
NC score	0.004850 (rank : 1406)	θ value	3.0926 (rank : 1135)
Query Neighborhood Hits	1311	Target Neighborhood Hits	56	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WV70, Q8VE16	Gene names	Noc2l
Domain Architecture
Description	Nucleolar complex protein 2 homolog (Protein NOC2 homolog) (NOC2- like).

CN037_MOUSE
NC score	0.004773 (rank : 1407)	θ value	5.27518 (rank : 1196)
Query Neighborhood Hits	1311	Target Neighborhood Hits	179	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BT18, Q8BFQ7, Q8R1Q5, Q9D6C5	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf37 homolog precursor.

AN32C_HUMAN
NC score	0.004752 (rank : 1408)	θ value	6.88961 (rank : 1224)
Query Neighborhood Hits	1311	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	O43423	Gene names	ANP32C, PP32R1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member C (Phosphoprotein 32-related protein 1) (Tumorigenic protein pp32r1).

SPRL1_HUMAN
NC score	0.004557 (rank : 1409)	θ value	5.27518 (rank : 1217)
Query Neighborhood Hits	1311	Target Neighborhood Hits	231	Shared Neighborhood Hits	52
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

OXRP_HUMAN
NC score	0.004530 (rank : 1410)	θ value	1.38821 (rank : 1045)
Query Neighborhood Hits	1311	Target Neighborhood Hits	544	Shared Neighborhood Hits	140
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

AN32E_HUMAN
NC score	0.004359 (rank : 1411)	θ value	4.03905 (rank : 1156)
Query Neighborhood Hits	1311	Target Neighborhood Hits	291	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BTT0, Q8N1S4, Q8WWW9	Gene names	ANP32E
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L).

TRI44_MOUSE
NC score	0.004258 (rank : 1412)	θ value	1.38821 (rank : 1049)
Query Neighborhood Hits	1311	Target Neighborhood Hits	327	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

CB013_MOUSE
NC score	0.004229 (rank : 1413)	θ value	1.81305 (rank : 1055)
Query Neighborhood Hits	1311	Target Neighborhood Hits	43	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D842, Q8BZL5, Q99LX6	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C2orf13 homolog.

SEPT8_HUMAN
NC score	0.004182 (rank : 1414)	θ value	8.99809 (rank : 1303)
Query Neighborhood Hits	1311	Target Neighborhood Hits	290	Shared Neighborhood Hits	90
SwissProt Accessions	Q92599, Q8IX36, Q8IX37, Q9BVB3	Gene names	SEPT8, KIAA0202
Domain Architecture
Description	Septin-8.

AN32A_HUMAN
NC score	0.003992 (rank : 1415)	θ value	0.813845 (rank : 985)
Query Neighborhood Hits	1311	Target Neighborhood Hits	234	Shared Neighborhood Hits	28
SwissProt Accessions	P39687	Gene names	ANP32A, C15orf1, LANP, MAPM, PHAP1
Domain Architecture	No domain graphic available
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member A (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Acidic nuclear phosphoprotein pp32) (Leucine-rich acidic nuclear protein) (Lanp) (Putative HLA-DR-associated protein I) (PHAPI) (Mapmodulin).

CHD9_MOUSE
NC score	0.003959 (rank : 1416)	θ value	5.27518 (rank : 1194)
Query Neighborhood Hits	1311	Target Neighborhood Hits	427	Shared Neighborhood Hits	107
SwissProt Accessions	Q8BYH8, Q7TMV5, Q8BJG8, Q8BZJ2, Q8CHG8	Gene names	Chd9, Kiaa0308, Pric320
Domain Architecture	No domain graphic available
Description	Chromodomain-helicase-DNA-binding protein 9 (EC 3.6.1.-) (ATP- dependent helicase CHD9) (CHD-9) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) (PPAR-alpha- interacting complex protein 320 kDa).

ARHGC_MOUSE
NC score	0.003925 (rank : 1417)	θ value	5.27518 (rank : 1187)
Query Neighborhood Hits	1311	Target Neighborhood Hits	344	Shared Neighborhood Hits	57
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CCNB3_MOUSE
NC score	0.003921 (rank : 1418)	θ value	5.27518 (rank : 1191)
Query Neighborhood Hits	1311	Target Neighborhood Hits	211	Shared Neighborhood Hits	58
SwissProt Accessions	Q810T2, Q810T3, Q8VDC8	Gene names	Ccnb3, Cycb3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

HUWE1_HUMAN
NC score	0.003884 (rank : 1419)	θ value	0.365318 (rank : 942)
Query Neighborhood Hits	1311	Target Neighborhood Hits	443	Shared Neighborhood Hits	78
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
NC score	0.003849 (rank : 1420)	θ value	0.365318 (rank : 943)
Query Neighborhood Hits	1311	Target Neighborhood Hits	406	Shared Neighborhood Hits	75
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

TXD13_HUMAN
NC score	0.003730 (rank : 1421)	θ value	1.81305 (rank : 1075)
Query Neighborhood Hits	1311	Target Neighborhood Hits	106	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H1E5, Q8N4P7, Q8NCC1, Q9UJA1, Q9ULQ8	Gene names	TXNDC13, KIAA1162
Domain Architecture
Description	Thioredoxin domain-containing protein 13 precursor.

K0319_MOUSE
NC score	0.003668 (rank : 1422)	θ value	4.03905 (rank : 1163)
Query Neighborhood Hits	1311	Target Neighborhood Hits	134	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SZV5, Q80U39	Gene names	Kiaa0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

SEPT8_MOUSE
NC score	0.003392 (rank : 1423)	θ value	8.99809 (rank : 1304)
Query Neighborhood Hits	1311	Target Neighborhood Hits	251	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CHH9, Q80YC7, Q9ESF7	Gene names	Sept8, Kiaa0202
Domain Architecture
Description	Septin-8.

K0256_HUMAN
NC score	0.003363 (rank : 1424)	θ value	1.38821 (rank : 1042)
Query Neighborhood Hits	1311	Target Neighborhood Hits	73	Shared Neighborhood Hits	11
SwissProt Accessions	Q93073, Q8N767	Gene names	KIAA0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

FYV1_HUMAN
NC score	0.003325 (rank : 1425)	θ value	2.36792 (rank : 1090)
Query Neighborhood Hits	1311	Target Neighborhood Hits	217	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

NCKX1_HUMAN
NC score	0.003274 (rank : 1426)	θ value	2.36792 (rank : 1095)
Query Neighborhood Hits	1311	Target Neighborhood Hits	223	Shared Neighborhood Hits	41
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

IRF2_HUMAN
NC score	0.003176 (rank : 1427)	θ value	0.813845 (rank : 996)
Query Neighborhood Hits	1311	Target Neighborhood Hits	35	Shared Neighborhood Hits	7
SwissProt Accessions	P14316, Q96B99	Gene names	IRF2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

SH3BG_MOUSE
NC score	0.003139 (rank : 1428)	θ value	3.0926 (rank : 1144)
Query Neighborhood Hits	1311	Target Neighborhood Hits	99	Shared Neighborhood Hits	23
SwissProt Accessions	Q9WUZ7	Gene names	Sh3bgr
Domain Architecture
Description	SH3 domain-binding glutamic acid-rich protein (SH3BGR protein).

DHX29_MOUSE
NC score	0.003132 (rank : 1429)	θ value	0.47712 (rank : 959)
Query Neighborhood Hits	1311	Target Neighborhood Hits	103	Shared Neighborhood Hits	26
SwissProt Accessions	Q6PGC1, Q8BQJ4, Q8BT01, Q8C9B7, Q8C9H9	Gene names	Dhx29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29).

LRC56_HUMAN
NC score	0.003070 (rank : 1430)	θ value	1.06291 (rank : 1019)
Query Neighborhood Hits	1311	Target Neighborhood Hits	165	Shared Neighborhood Hits	19
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

NOG2_MOUSE
NC score	0.002987 (rank : 1431)	θ value	4.03905 (rank : 1168)
Query Neighborhood Hits	1311	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	Q99LH1, Q8BIF8	Gene names	Gnl2
Domain Architecture	No domain graphic available
Description	Nucleolar GTP-binding protein 2.

TE2IP_MOUSE
NC score	0.002821 (rank : 1432)	θ value	3.0926 (rank : 1149)
Query Neighborhood Hits	1311	Target Neighborhood Hits	48	Shared Neighborhood Hits	7
SwissProt Accessions	Q91VL8, Q543F4, Q9JJE8, Q9JJE9	Gene names	Terf2ip, Rap1
Domain Architecture	No domain graphic available
Description	Telomeric repeat-binding factor 2-interacting protein 1 (TRF2- interacting telomeric protein Rap1).

AN13A_MOUSE
NC score	0.002793 (rank : 1433)	θ value	6.88961 (rank : 1223)
Query Neighborhood Hits	1311	Target Neighborhood Hits	226	Shared Neighborhood Hits	25
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

HRX_HUMAN
NC score	0.002732 (rank : 1434)	θ value	2.36792 (rank : 1091)
Query Neighborhood Hits	1311	Target Neighborhood Hits	825	Shared Neighborhood Hits	107
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

CND1_HUMAN
NC score	0.002671 (rank : 1435)	θ value	5.27518 (rank : 1198)
Query Neighborhood Hits	1311	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	Q15021, Q8N6U3	Gene names	NCAPD2, CAPD2, CNAP1, KIAA0159
Domain Architecture
Description	Condensin complex subunit 1 (Non-SMC condensin I complex subunit D2) (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (XCAP-D2 homolog).

SRPR_HUMAN
NC score	0.002586 (rank : 1436)	θ value	3.0926 (rank : 1146)
Query Neighborhood Hits	1311	Target Neighborhood Hits	42	Shared Neighborhood Hits	8
SwissProt Accessions	P08240, Q9BVJ4	Gene names	SRPR
Domain Architecture
Description	Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha).

DPOE3_HUMAN
NC score	0.002564 (rank : 1437)	θ value	5.27518 (rank : 1202)
Query Neighborhood Hits	1311	Target Neighborhood Hits	54	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRF9, Q5W0U1, Q8N758, Q8NCE5, Q9NR32	Gene names	POLE3, CHRAC17
Domain Architecture
Description	DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) (Chromatin accessibility complex 17) (HuCHRAC17) (CHRAC-17) (Arsenic- transactivated protein) (AsTP).

PP2CG_HUMAN
NC score	0.002516 (rank : 1438)	θ value	1.06291 (rank : 1022)
Query Neighborhood Hits	1311	Target Neighborhood Hits	140	Shared Neighborhood Hits	28
SwissProt Accessions	O15355	Gene names	PPM1G, PPM1C
Domain Architecture
Description	Protein phosphatase 2C isoform gamma (EC 3.1.3.16) (PP2C-gamma) (Protein phosphatase magnesium-dependent 1 gamma) (Protein phosphatase 1C).

K1C19_MOUSE
NC score	0.002506 (rank : 1439)	θ value	8.99809 (rank : 1279)
Query Neighborhood Hits	1311	Target Neighborhood Hits	358	Shared Neighborhood Hits	109
SwissProt Accessions	P19001	Gene names	Krt19, Krt1-19
Domain Architecture
Description	Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19).

TAIP2_HUMAN
NC score	0.002377 (rank : 1440)	θ value	1.81305 (rank : 1073)
Query Neighborhood Hits	1311	Target Neighborhood Hits	37	Shared Neighborhood Hits	11
SwissProt Accessions	Q8WYN3	Gene names	TAIP2
Domain Architecture	No domain graphic available
Description	TGF-beta-induced apoptosis protein 2 (TAIP-2).

LRC59_MOUSE
NC score	0.002298 (rank : 1441)	θ value	8.99809 (rank : 1282)
Query Neighborhood Hits	1311	Target Neighborhood Hits	415	Shared Neighborhood Hits	72
SwissProt Accessions	Q922Q8, Q3TJ35, Q3TLC7, Q3TWT9, Q3TX86	Gene names	Lrrc59
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 59.

AN32E_MOUSE
NC score	0.002268 (rank : 1442)	θ value	6.88961 (rank : 1225)
Query Neighborhood Hits	1311	Target Neighborhood Hits	257	Shared Neighborhood Hits	32
SwissProt Accessions	P97822, Q3TH89, Q8BPF8, Q8C2L4, Q8C7Q8, Q9CZD2	Gene names	Anp32e, Cpd1
Domain Architecture
Description	Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP- like protein) (LANP-L) (Cerebellar postnatal development protein 1).

NBR1_HUMAN
NC score	0.002263 (rank : 1443)	θ value	6.88961 (rank : 1242)
Query Neighborhood Hits	1311	Target Neighborhood Hits	105	Shared Neighborhood Hits	22
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

RN168_HUMAN
NC score	0.002193 (rank : 1444)	θ value	2.36792 (rank : 1104)
Query Neighborhood Hits	1311	Target Neighborhood Hits	370	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

VAPB_HUMAN
NC score	0.002177 (rank : 1445)	θ value	8.99809 (rank : 1310)
Query Neighborhood Hits	1311	Target Neighborhood Hits	39	Shared Neighborhood Hits	16
SwissProt Accessions	O95292, O95293, Q9P0H0	Gene names	VAPB
Domain Architecture
Description	Vesicle-associated membrane protein-associated protein B/C (VAMP- associated protein B/C) (VAMP-B/VAMP-C) (VAP-B/VAP-C).

IPO7_HUMAN
NC score	0.002157 (rank : 1446)	θ value	1.38821 (rank : 1040)
Query Neighborhood Hits	1311	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	O95373, Q9H177, Q9NTE3	Gene names	IPO7, RANBP7
Domain Architecture
Description	Importin-7 (Imp7) (Ran-binding protein 7) (RanBP7).

AP3B1_MOUSE
NC score	0.002157 (rank : 1447)	θ value	1.81305 (rank : 1052)
Query Neighborhood Hits	1311	Target Neighborhood Hits	302	Shared Neighborhood Hits	53
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

FOSB_HUMAN
NC score	0.001988 (rank : 1448)	θ value	8.99809 (rank : 1275)
Query Neighborhood Hits	1311	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	P53539	Gene names	FOSB, G0S3
Domain Architecture	No domain graphic available
Description	Protein fosB (G0/G1 switch regulatory protein 3).

IRF2_MOUSE
NC score	0.001955 (rank : 1449)	θ value	1.38821 (rank : 1041)
Query Neighborhood Hits	1311	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	P23906	Gene names	Irf2
Domain Architecture
Description	Interferon regulatory factor 2 (IRF-2).

DHX29_HUMAN
NC score	0.001689 (rank : 1450)	θ value	3.0926 (rank : 1125)
Query Neighborhood Hits	1311	Target Neighborhood Hits	144	Shared Neighborhood Hits	34
SwissProt Accessions	Q7Z478, O75549, Q63HN0, Q63HN3, Q8IWW2, Q8N3A1, Q9UMH2	Gene names	DHX29
Domain Architecture	No domain graphic available
Description	Putative ATP-dependent RNA helicase DHX29 (EC 3.6.1.-) (DEAH box protein 29) (Nucleic acid helicase DDXx).

FYV1_MOUSE
NC score	0.001433 (rank : 1451)	θ value	3.0926 (rank : 1129)
Query Neighborhood Hits	1311	Target Neighborhood Hits	191	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

PTPRG_HUMAN
NC score	0.001358 (rank : 1452)	θ value	0.000786445 (rank : 810)
Query Neighborhood Hits	1311	Target Neighborhood Hits	231	Shared Neighborhood Hits	37
SwissProt Accessions	P23470, Q15623	Gene names	PTPRG
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase gamma precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase gamma) (R-PTP-gamma).

RRS1_MOUSE
NC score	0.001222 (rank : 1453)	θ value	8.99809 (rank : 1300)
Query Neighborhood Hits	1311	Target Neighborhood Hits	28	Shared Neighborhood Hits	8
SwissProt Accessions	Q9CYH6, Q3UQW6, Q9CS27, Q9D2B2, Q9D6M6, Q9JJC1	Gene names	Rrs1, Rrr
Domain Architecture
Description	Ribosome biogenesis regulatory protein homolog.

NOL4_HUMAN
NC score	0.001219 (rank : 1454)	θ value	8.99809 (rank : 1291)
Query Neighborhood Hits	1311	Target Neighborhood Hits	33	Shared Neighborhood Hits	13
SwissProt Accessions	O94818, Q9BWF1	Gene names	NOL4, NOLP
Domain Architecture	No domain graphic available
Description	Nucleolar protein 4 (Nucleolar-localized protein).

RTN2_MOUSE
NC score	0.001173 (rank : 1455)	θ value	3.0926 (rank : 1142)
Query Neighborhood Hits	1311	Target Neighborhood Hits	48	Shared Neighborhood Hits	11
SwissProt Accessions	O70622, O70620	Gene names	Rtn2, Nspl1
Domain Architecture
Description	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (NSPLI).

BCCIP_MOUSE
NC score	0.001068 (rank : 1456)	θ value	8.99809 (rank : 1263)
Query Neighborhood Hits	1311	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	Q9CWI3, Q9D1E0	Gene names	Bccip
Domain Architecture	No domain graphic available
Description	BRCA2 and CDKN1A-interacting protein.

A16L1_HUMAN
NC score	0.000997 (rank : 1457)	θ value	6.88961 (rank : 1222)
Query Neighborhood Hits	1311	Target Neighborhood Hits	664	Shared Neighborhood Hits	131
SwissProt Accessions	Q676U5, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619	Gene names	ATG16L1, APG16L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

DC1I2_HUMAN
NC score	0.000964 (rank : 1458)	θ value	0.62314 (rank : 971)
Query Neighborhood Hits	1311	Target Neighborhood Hits	201	Shared Neighborhood Hits	25
SwissProt Accessions	Q13409, Q96NG7, Q96S87, Q9BXZ5, Q9NT58	Gene names	DYNC1I2, DNCI2, DNCIC2
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 2 (Dynein intermediate chain 2, cytosolic) (DH IC-2) (Cytoplasmic dynein intermediate chain 2).

FAS_MOUSE
NC score	0.000892 (rank : 1459)	θ value	1.06291 (rank : 1013)
Query Neighborhood Hits	1311	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	P19096, Q6PB72, Q8C4Z0, Q9EQR0	Gene names	Fasn
Domain Architecture	No domain graphic available
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

CLGN_HUMAN
NC score	0.000864 (rank : 1460)	θ value	3.0926 (rank : 1122)
Query Neighborhood Hits	1311	Target Neighborhood Hits	111	Shared Neighborhood Hits	35
SwissProt Accessions	O14967	Gene names	CLGN
Domain Architecture
Description	Calmegin precursor.

K0323_MOUSE
NC score	0.000517 (rank : 1461)	θ value	8.99809 (rank : 1278)
Query Neighborhood Hits	1311	Target Neighborhood Hits	33	Shared Neighborhood Hits	7
SwissProt Accessions	Q80U38, Q8BGJ6, Q8C082	Gene names	Kiaa0323
Domain Architecture	No domain graphic available
Description	Protein KIAA0323.

DNJC3_MOUSE
NC score	0.000140 (rank : 1462)	θ value	0.125558 (rank : 890)
Query Neighborhood Hits	1311	Target Neighborhood Hits	230	Shared Neighborhood Hits	38
SwissProt Accessions	Q91YW3, Q60873	Gene names	Dnajc3, P58ipk
Domain Architecture	No domain graphic available
Description	DnaJ homolog subfamily C member 3 (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor p58) (Protein kinase inhibitor of 58 kDa).

CHD1_HUMAN
NC score	-0.000065 (rank : 1463)	θ value	5.27518 (rank : 1193)
Query Neighborhood Hits	1311	Target Neighborhood Hits	337	Shared Neighborhood Hits	62
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

WDR43_HUMAN
NC score	-0.000167 (rank : 1464)	θ value	0.21417 (rank : 918)
Query Neighborhood Hits	1311	Target Neighborhood Hits	269	Shared Neighborhood Hits	26
SwissProt Accessions	Q15061, Q15395, Q92577	Gene names	WDR43, KIAA0007
Domain Architecture	No domain graphic available
Description	WD repeat protein 43.

ZO1_HUMAN
NC score	-0.000365 (rank : 1465)	θ value	6.88961 (rank : 1259)
Query Neighborhood Hits	1311	Target Neighborhood Hits	474	Shared Neighborhood Hits	56
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

WDR81_MOUSE
NC score	-0.000721 (rank : 1466)	θ value	0.62314 (rank : 984)
Query Neighborhood Hits	1311	Target Neighborhood Hits	228	Shared Neighborhood Hits	16
SwissProt Accessions	Q5ND34, Q3TA90, Q3TUS9, Q6KAR1	Gene names	Wdr81
Domain Architecture	No domain graphic available
Description	WD repeat protein 81.

DHX9_HUMAN
NC score	-0.000867 (rank : 1467)	θ value	5.27518 (rank : 1201)
Query Neighborhood Hits	1311	Target Neighborhood Hits	62	Shared Neighborhood Hits	10
SwissProt Accessions	Q08211, Q5VY62, Q6PD69, Q99556	Gene names	DHX9, DDX9, NDH2
Domain Architecture
Description	ATP-dependent RNA helicase A (EC 3.6.1.-) (Nuclear DNA helicase II) (NDH II) (DEAH box protein 9).

RPGF6_HUMAN
NC score	-0.001000 (rank : 1468)	θ value	4.03905 (rank : 1176)
Query Neighborhood Hits	1311	Target Neighborhood Hits	266	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

EDD1_HUMAN
NC score	-0.001052 (rank : 1469)	θ value	6.88961 (rank : 1235)
Query Neighborhood Hits	1311	Target Neighborhood Hits	170	Shared Neighborhood Hits	24
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

OSBL6_HUMAN
NC score	-0.001102 (rank : 1470)	θ value	5.27518 (rank : 1212)
Query Neighborhood Hits	1311	Target Neighborhood Hits	101	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL6_MOUSE
NC score	-0.001280 (rank : 1471)	θ value	8.99809 (rank : 1292)
Query Neighborhood Hits	1311	Target Neighborhood Hits	105	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

DC1I1_HUMAN
NC score	-0.001348 (rank : 1472)	θ value	8.99809 (rank : 1270)
Query Neighborhood Hits	1311	Target Neighborhood Hits	183	Shared Neighborhood Hits	28
SwissProt Accessions	O14576, Q9Y2X1	Gene names	DYNC1I1, DNCI1, DNCIC1
Domain Architecture
Description	Cytoplasmic dynein 1 intermediate chain 1 (Dynein intermediate chain 1, cytosolic) (DH IC-1) (Cytoplasmic dynein intermediate chain 1).

B4GN3_HUMAN
NC score	-0.001430 (rank : 1473)	θ value	6.88961 (rank : 1228)
Query Neighborhood Hits	1311	Target Neighborhood Hits	128	Shared Neighborhood Hits	12
SwissProt Accessions	Q6L9W6, Q6ZNC1, Q8N7T6	Gene names	B4GALNT3
Domain Architecture	No domain graphic available
Description	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase 2 (EC 2.4.1.244) (NGalNAc-T2) (Beta- 1,4-N-acetylgalactosaminyltransferase III) (Beta4GalNAc-T3) (Beta4GalNAcT3).

ATR_HUMAN
NC score	-0.001659 (rank : 1474)	θ value	8.99809 (rank : 1262)
Query Neighborhood Hits	1311	Target Neighborhood Hits	71	Shared Neighborhood Hits	13
SwissProt Accessions	Q13535, Q7KYL3, Q93051, Q9BXK4	Gene names	ATR, FRP1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein) (FRAP-related protein 1).

G3BP_HUMAN
NC score	-0.001854 (rank : 1475)	θ value	6.88961 (rank : 1236)
Query Neighborhood Hits	1311	Target Neighborhood Hits	219	Shared Neighborhood Hits	29
SwissProt Accessions	Q13283	Gene names	G3BP, G3BP1
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 1 (EC 3.6.1.-) (ATP- dependent DNA helicase VIII) (GAP SH3-domain-binding protein 1) (G3BP- 1) (HDH-VIII).

E41L3_HUMAN
NC score	-0.001934 (rank : 1476)	θ value	1.81305 (rank : 1061)
Query Neighborhood Hits	1311	Target Neighborhood Hits	113	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

JADE1_MOUSE
NC score	-0.002271 (rank : 1477)	θ value	8.99809 (rank : 1277)
Query Neighborhood Hits	1311	Target Neighborhood Hits	160	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZPI0, Q6IE84, Q8C7S6, Q8CFM2, Q8R362	Gene names	Phf17, Jade1, Kiaa1807
Domain Architecture	No domain graphic available
Description	Protein Jade-1 (PHD finger protein 17).

LRCH2_MOUSE
NC score	-0.002390 (rank : 1478)	θ value	0.47712 (rank : 965)
Query Neighborhood Hits	1311	Target Neighborhood Hits	287	Shared Neighborhood Hits	23
SwissProt Accessions	Q3UMG5, Q7TNP9, Q80TC9	Gene names	Lrch2, Kiaa1495
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and calponin homology domain-containing protein 2.

NUCL_HUMAN
NC score	-0.002774 (rank : 1479)	θ value	4.03905 (rank : 1171)
Query Neighborhood Hits	1311	Target Neighborhood Hits	415	Shared Neighborhood Hits	55
SwissProt Accessions	P19338, Q53SK1, Q8NB06	Gene names	NCL
Domain Architecture
Description	Nucleolin (Protein C23).

RU17_MOUSE
NC score	-0.002898 (rank : 1480)	θ value	1.38821 (rank : 1046)
Query Neighborhood Hits	1311	Target Neighborhood Hits	278	Shared Neighborhood Hits	32
SwissProt Accessions	Q62376, Q3UIW4	Gene names	Snrp70
Domain Architecture	No domain graphic available
Description	U1 small nuclear ribonucleoprotein 70 kDa (U1 SNRNP 70 kDa) (snRNP70).

CHD5_HUMAN
NC score	-0.003535 (rank : 1481)	θ value	3.0926 (rank : 1119)
Query Neighborhood Hits	1311	Target Neighborhood Hits	349	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TDI0, O75032, Q5TG89, Q9UFR9	Gene names	CHD5
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 5 (EC 3.6.1.-) (ATP- dependent helicase CHD5) (CHD-5).

SCN1A_HUMAN
NC score	-0.003537 (rank : 1482)	θ value	4.03905 (rank : 1177)
Query Neighborhood Hits	1311	Target Neighborhood Hits	148	Shared Neighborhood Hits	31
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

UBP49_MOUSE
NC score	-0.003612 (rank : 1483)	θ value	1.38821 (rank : 1050)
Query Neighborhood Hits	1311	Target Neighborhood Hits	91	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9L4	Gene names	Usp49
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.1.2.15) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49) (Deubiquitinating enzyme 49).

NUCL_MOUSE
NC score	-0.003621 (rank : 1484)	θ value	0.813845 (rank : 1000)
Query Neighborhood Hits	1311	Target Neighborhood Hits	425	Shared Neighborhood Hits	52
SwissProt Accessions	P09405, Q548M9, Q61991, Q99K50	Gene names	Ncl, Nuc
Domain Architecture
Description	Nucleolin (Protein C23).

RU17_HUMAN
NC score	-0.004256 (rank : 1485)	θ value	6.88961 (rank : 1248)
Query Neighborhood Hits	1311	Target Neighborhood Hits	280	Shared Neighborhood Hits	38
SwissProt Accessions	P08621, P78493, P78494, Q15364, Q15686, Q15687, Q15689, Q99377, Q9UE45, Q9UE46, Q9UE47, Q9UE48, Q9UFQ6	Gene names	SNRP70, RPU1, U1AP1
Domain Architecture
Description	U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (snRNP70) (U1-70K).

RN146_HUMAN
NC score	-0.004289 (rank : 1486)	θ value	5.27518 (rank : 1214)
Query Neighborhood Hits	1311	Target Neighborhood Hits	162	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

PTPR2_MOUSE
NC score	-0.004436 (rank : 1487)	θ value	1.81305 (rank : 1069)
Query Neighborhood Hits	1311	Target Neighborhood Hits	120	Shared Neighborhood Hits	9
SwissProt Accessions	P80560, O09134, P70328	Gene names	Ptprn2
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase N2 precursor (EC 3.1.3.48) (R-PTP-N2) (PTP IA-2beta) (Protein tyrosine phosphatase-NP) (PTP-NP).

PK2L2_MOUSE
NC score	-0.004496 (rank : 1488)	θ value	8.99809 (rank : 1295)
Query Neighborhood Hits	1311	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

LRRC2_MOUSE
NC score	-0.004742 (rank : 1489)	θ value	8.99809 (rank : 1283)
Query Neighborhood Hits	1311	Target Neighborhood Hits	238	Shared Neighborhood Hits	10
SwissProt Accessions	Q8VDB8, Q9CX04	Gene names	Lrrc2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 2.

LAP2_MOUSE
NC score	-0.005320 (rank : 1490)	θ value	0.813845 (rank : 997)
Query Neighborhood Hits	1311	Target Neighborhood Hits	482	Shared Neighborhood Hits	43
SwissProt Accessions	Q80TH2, Q8BQ14, Q8CE41, Q8K171, Q99JU3, Q9JI47	Gene names	Erbb2ip, Erbin, Kiaa1225, Lap2
Domain Architecture	No domain graphic available
Description	Protein LAP2 (Erbb2-interacting protein) (Erbin) (Densin-180-like protein).

AR13B_MOUSE
NC score	-0.005329 (rank : 1491)	θ value	6.88961 (rank : 1226)
Query Neighborhood Hits	1311	Target Neighborhood Hits	245	Shared Neighborhood Hits	26
SwissProt Accessions	Q640N2	Gene names	Arl13b, Arl2l1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

CSTN1_MOUSE
NC score	-0.006791 (rank : 1492)	θ value	4.03905 (rank : 1159)
Query Neighborhood Hits	1311	Target Neighborhood Hits	175	Shared Neighborhood Hits	9
SwissProt Accessions	Q9EPL2	Gene names	Clstn1, Cs1, Cstn1
Domain Architecture
Description	Calsyntenin-1 precursor.

COBA1_HUMAN
NC score	-0.009739 (rank : 1493)	θ value	3.0926 (rank : 1123)
Query Neighborhood Hits	1311	Target Neighborhood Hits	491	Shared Neighborhood Hits	36
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

TSH3_HUMAN
NC score	-0.010803 (rank : 1494)	θ value	8.99809 (rank : 1308)
Query Neighborhood Hits	1311	Target Neighborhood Hits	564	Shared Neighborhood Hits	20
SwissProt Accessions	Q63HK5, Q9H0G6, Q9P254	Gene names	TSHZ3, KIAA1474, TSH3, ZNF537
Domain Architecture	No domain graphic available
Description	Teashirt homolog 3 (Zinc finger protein 537).

KBTB6_HUMAN
NC score	-0.011129 (rank : 1495)	θ value	5.27518 (rank : 1206)
Query Neighborhood Hits	1311	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q86V97, Q8N8L0, Q8NDM5, Q96MP6	Gene names	KBTBD6
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 6.

CSPG2_HUMAN
NC score	-0.014351 (rank : 1496)	θ value	8.99809 (rank : 1268)
Query Neighborhood Hits	1311	Target Neighborhood Hits	681	Shared Neighborhood Hits	37
SwissProt Accessions	P13611, P20754, Q13010, Q13189, Q15123, Q9UCL9, Q9UNW5	Gene names	CSPG2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M) (Glial hyaluronate-binding protein) (GHAP).

ATBF1_MOUSE
NC score	-0.016078 (rank : 1497)	θ value	1.81305 (rank : 1054)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1841	Shared Neighborhood Hits	152
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

IPF1_HUMAN
NC score	-0.016594 (rank : 1498)	θ value	3.0926 (rank : 1131)
Query Neighborhood Hits	1311	Target Neighborhood Hits	330	Shared Neighborhood Hits	3
SwissProt Accessions	P52945, O60594	Gene names	IPF1, PDX1
Domain Architecture
Description	Insulin promoter factor 1 (IPF-1) (Pancreas/duodenum homeobox 1) (PDX- 1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1) (Insulin upstream factor 1) (IUF-1) (Glucose- sensitive factor) (GSF).

TCF8_HUMAN
NC score	-0.023637 (rank : 1499)	θ value	0.279714 (rank : 936)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1057	Shared Neighborhood Hits	107
SwissProt Accessions	P37275, Q12924, Q13800	Gene names	TCF8, AREB6
Domain Architecture
Description	Transcription factor 8 (NIL-2-A zinc finger protein) (Negative regulator of IL2).

TCF8_MOUSE
NC score	-0.024721 (rank : 1500)	θ value	0.813845 (rank : 1005)
Query Neighborhood Hits	1311	Target Neighborhood Hits	1067	Shared Neighborhood Hits	98
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ZNF96_HUMAN
NC score	-0.026164 (rank : 1501)	θ value	6.88961 (rank : 1258)
Query Neighborhood Hits	1311	Target Neighborhood Hits	869	Shared Neighborhood Hits	48
SwissProt Accessions	O43309, O43724	Gene names	ZNF96, KIAA0426, ZNF305, ZSCAN12
Domain Architecture
Description	Zinc finger protein 96 (Zinc finger protein 305) (Zinc finger and SCAN domain-containing protein 12).