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Network neighborhood for query Sequence : SCN1A_HUMAN

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SCN1A_HUMAN
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SC10A_HUMAN
θ value	0 (rank : 1)	NC score	0.992373 (rank : 7)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
θ value	0 (rank : 2)	NC score	0.991929 (rank : 8)
Query Neighborhood Hits	148	Target Neighborhood Hits	107	Shared Neighborhood Hits	66
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC11A_HUMAN
θ value	0 (rank : 3)	NC score	0.983180 (rank : 13)
Query Neighborhood Hits	148	Target Neighborhood Hits	111	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC11A_MOUSE
θ value	0 (rank : 4)	NC score	0.984738 (rank : 12)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN1A_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	148
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0 (rank : 6)	NC score	0.997105 (rank : 2)
Query Neighborhood Hits	148	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
θ value	0 (rank : 7)	NC score	0.996482 (rank : 3)
Query Neighborhood Hits	148	Target Neighborhood Hits	115	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
θ value	0 (rank : 8)	NC score	0.991367 (rank : 9)
Query Neighborhood Hits	148	Target Neighborhood Hits	133	Shared Neighborhood Hits	70
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
θ value	0 (rank : 9)	NC score	0.986532 (rank : 10)
Query Neighborhood Hits	148	Target Neighborhood Hits	145	Shared Neighborhood Hits	72
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN7A_HUMAN
θ value	0 (rank : 10)	NC score	0.985313 (rank : 11)
Query Neighborhood Hits	148	Target Neighborhood Hits	135	Shared Neighborhood Hits	56
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN8A_HUMAN
θ value	0 (rank : 11)	NC score	0.994527 (rank : 6)
Query Neighborhood Hits	148	Target Neighborhood Hits	135	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	0 (rank : 12)	NC score	0.995339 (rank : 4)
Query Neighborhood Hits	148	Target Neighborhood Hits	136	Shared Neighborhood Hits	87
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN9A_HUMAN
θ value	0 (rank : 13)	NC score	0.994925 (rank : 5)
Query Neighborhood Hits	148	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

CAC1A_MOUSE
θ value	4.99229e-75 (rank : 14)	NC score	0.851868 (rank : 19)
Query Neighborhood Hits	148	Target Neighborhood Hits	267	Shared Neighborhood Hits	63
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_HUMAN
θ value	1.11217e-74 (rank : 15)	NC score	0.844102 (rank : 23)
Query Neighborhood Hits	148	Target Neighborhood Hits	387	Shared Neighborhood Hits	66
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1I_HUMAN
θ value	3.57772e-73 (rank : 16)	NC score	0.893084 (rank : 14)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1D_HUMAN
θ value	1.96316e-71 (rank : 17)	NC score	0.843867 (rank : 24)
Query Neighborhood Hits	148	Target Neighborhood Hits	118	Shared Neighborhood Hits	60
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1B_MOUSE
θ value	1.66191e-70 (rank : 18)	NC score	0.841975 (rank : 26)
Query Neighborhood Hits	148	Target Neighborhood Hits	351	Shared Neighborhood Hits	61
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1H_MOUSE
θ value	1.66191e-70 (rank : 19)	NC score	0.872736 (rank : 15)
Query Neighborhood Hits	148	Target Neighborhood Hits	230	Shared Neighborhood Hits	61
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1G_HUMAN
θ value	3.70236e-70 (rank : 20)	NC score	0.849262 (rank : 20)
Query Neighborhood Hits	148	Target Neighborhood Hits	587	Shared Neighborhood Hits	59
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1E_HUMAN
θ value	3.13423e-69 (rank : 21)	NC score	0.855226 (rank : 18)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1H_HUMAN
θ value	3.13423e-69 (rank : 22)	NC score	0.865624 (rank : 16)
Query Neighborhood Hits	148	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1E_MOUSE
θ value	4.09345e-69 (rank : 23)	NC score	0.855745 (rank : 17)
Query Neighborhood Hits	148	Target Neighborhood Hits	167	Shared Neighborhood Hits	66
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1S_MOUSE
θ value	9.11921e-69 (rank : 24)	NC score	0.844435 (rank : 22)
Query Neighborhood Hits	148	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_HUMAN
θ value	6.53529e-67 (rank : 25)	NC score	0.843179 (rank : 25)
Query Neighborhood Hits	148	Target Neighborhood Hits	92	Shared Neighborhood Hits	55
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_HUMAN
θ value	1.11475e-66 (rank : 26)	NC score	0.844847 (rank : 21)
Query Neighborhood Hits	148	Target Neighborhood Hits	257	Shared Neighborhood Hits	60
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1C_MOUSE
θ value	1.36269e-64 (rank : 27)	NC score	0.836675 (rank : 29)
Query Neighborhood Hits	148	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1F_HUMAN
θ value	1.50663e-63 (rank : 28)	NC score	0.837717 (rank : 28)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	61
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_MOUSE
θ value	2.56992e-63 (rank : 29)	NC score	0.838548 (rank : 27)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_HUMAN
θ value	5.92465e-60 (rank : 30)	NC score	0.831669 (rank : 30)
Query Neighborhood Hits	148	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

KCNB2_HUMAN
θ value	1.09739e-05 (rank : 31)	NC score	0.209533 (rank : 37)
Query Neighborhood Hits	148	Target Neighborhood Hits	212	Shared Neighborhood Hits	54
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNF1_HUMAN
θ value	7.1131e-05 (rank : 32)	NC score	0.224962 (rank : 36)
Query Neighborhood Hits	148	Target Neighborhood Hits	109	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNB1_HUMAN
θ value	0.00035302 (rank : 33)	NC score	0.189575 (rank : 42)
Query Neighborhood Hits	148	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	0.00035302 (rank : 34)	NC score	0.189668 (rank : 41)
Query Neighborhood Hits	148	Target Neighborhood Hits	154	Shared Neighborhood Hits	53
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCND3_HUMAN
θ value	0.00509761 (rank : 35)	NC score	0.170625 (rank : 44)
Query Neighborhood Hits	148	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.00509761 (rank : 36)	NC score	0.170740 (rank : 43)
Query Neighborhood Hits	148	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

PK2L1_HUMAN
θ value	0.00665767 (rank : 37)	NC score	0.282681 (rank : 32)
Query Neighborhood Hits	148	Target Neighborhood Hits	132	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_HUMAN
θ value	0.00665767 (rank : 38)	NC score	0.262004 (rank : 35)
Query Neighborhood Hits	148	Target Neighborhood Hits	105	Shared Neighborhood Hits	45
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

IWS1_MOUSE
θ value	0.0113563 (rank : 39)	NC score	0.031866 (rank : 93)
Query Neighborhood Hits	148	Target Neighborhood Hits	1258	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

KCNV2_HUMAN
θ value	0.0113563 (rank : 40)	NC score	0.208234 (rank : 38)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

PK2L2_HUMAN
θ value	0.0113563 (rank : 41)	NC score	0.304278 (rank : 31)
Query Neighborhood Hits	148	Target Neighborhood Hits	90	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
θ value	0.0113563 (rank : 42)	NC score	0.269667 (rank : 33)
Query Neighborhood Hits	148	Target Neighborhood Hits	84	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

KCNS2_MOUSE
θ value	0.0148317 (rank : 43)	NC score	0.199956 (rank : 39)
Query Neighborhood Hits	148	Target Neighborhood Hits	130	Shared Neighborhood Hits	53
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

TRPC1_HUMAN
θ value	0.0148317 (rank : 44)	NC score	0.070510 (rank : 71)
Query Neighborhood Hits	148	Target Neighborhood Hits	91	Shared Neighborhood Hits	18
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	0.0148317 (rank : 45)	NC score	0.070580 (rank : 70)
Query Neighborhood Hits	148	Target Neighborhood Hits	87	Shared Neighborhood Hits	18
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

KCNC1_HUMAN
θ value	0.0193708 (rank : 46)	NC score	0.136618 (rank : 51)
Query Neighborhood Hits	148	Target Neighborhood Hits	133	Shared Neighborhood Hits	48
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

CK5P2_HUMAN
θ value	0.0252991 (rank : 47)	NC score	0.018526 (rank : 104)
Query Neighborhood Hits	148	Target Neighborhood Hits	1433	Shared Neighborhood Hits	52
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

KCNC1_MOUSE
θ value	0.0252991 (rank : 48)	NC score	0.134289 (rank : 52)
Query Neighborhood Hits	148	Target Neighborhood Hits	133	Shared Neighborhood Hits	48
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCND2_HUMAN
θ value	0.0252991 (rank : 49)	NC score	0.163081 (rank : 47)
Query Neighborhood Hits	148	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.0252991 (rank : 50)	NC score	0.163247 (rank : 46)
Query Neighborhood Hits	148	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCNS2_HUMAN
θ value	0.0252991 (rank : 51)	NC score	0.194669 (rank : 40)
Query Neighborhood Hits	148	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS3_HUMAN
θ value	0.0252991 (rank : 52)	NC score	0.168405 (rank : 45)
Query Neighborhood Hits	148	Target Neighborhood Hits	125	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

RBBP6_MOUSE
θ value	0.0252991 (rank : 53)	NC score	0.028676 (rank : 94)
Query Neighborhood Hits	148	Target Neighborhood Hits	1014	Shared Neighborhood Hits	31
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

IMMT_HUMAN
θ value	0.0563607 (rank : 54)	NC score	0.025932 (rank : 96)
Query Neighborhood Hits	148	Target Neighborhood Hits	494	Shared Neighborhood Hits	29
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

GOGA4_MOUSE
θ value	0.0736092 (rank : 55)	NC score	0.010016 (rank : 128)
Query Neighborhood Hits	148	Target Neighborhood Hits	1939	Shared Neighborhood Hits	53
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

KMHN1_MOUSE
θ value	0.0736092 (rank : 56)	NC score	0.019823 (rank : 100)
Query Neighborhood Hits	148	Target Neighborhood Hits	949	Shared Neighborhood Hits	41
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

PKD2_MOUSE
θ value	0.125558 (rank : 57)	NC score	0.265334 (rank : 34)
Query Neighborhood Hits	148	Target Neighborhood Hits	99	Shared Neighborhood Hits	47
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

CABP5_MOUSE
θ value	0.163984 (rank : 58)	NC score	0.058212 (rank : 84)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KCND1_MOUSE
θ value	0.163984 (rank : 59)	NC score	0.144689 (rank : 48)
Query Neighborhood Hits	148	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

MARK2_MOUSE
θ value	0.163984 (rank : 60)	NC score	-0.002525 (rank : 166)
Query Neighborhood Hits	148	Target Neighborhood Hits	1018	Shared Neighborhood Hits	8
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

TRPV3_HUMAN
θ value	0.163984 (rank : 61)	NC score	0.092997 (rank : 62)
Query Neighborhood Hits	148	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

LAMC2_HUMAN
θ value	0.21417 (rank : 62)	NC score	0.006295 (rank : 148)
Query Neighborhood Hits	148	Target Neighborhood Hits	715	Shared Neighborhood Hits	24
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

KCND1_HUMAN
θ value	0.279714 (rank : 63)	NC score	0.142930 (rank : 49)
Query Neighborhood Hits	148	Target Neighborhood Hits	160	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

PKDRE_HUMAN
θ value	0.279714 (rank : 64)	NC score	0.119512 (rank : 54)
Query Neighborhood Hits	148	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TPTE2_HUMAN
θ value	0.279714 (rank : 65)	NC score	0.139556 (rank : 50)
Query Neighborhood Hits	148	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

GLE1_MOUSE
θ value	0.47712 (rank : 66)	NC score	0.017782 (rank : 106)
Query Neighborhood Hits	148	Target Neighborhood Hits	504	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

CABP5_HUMAN
θ value	0.62314 (rank : 67)	NC score	0.042478 (rank : 91)
Query Neighborhood Hits	148	Target Neighborhood Hits	197	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

GOGA2_MOUSE
θ value	0.62314 (rank : 68)	NC score	0.017137 (rank : 107)
Query Neighborhood Hits	148	Target Neighborhood Hits	944	Shared Neighborhood Hits	44
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

DDX49_HUMAN
θ value	0.813845 (rank : 69)	NC score	0.011151 (rank : 122)
Query Neighborhood Hits	148	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

FA61A_HUMAN
θ value	0.813845 (rank : 70)	NC score	0.012788 (rank : 113)
Query Neighborhood Hits	148	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8ND56, Q76LX7, Q96AR3, Q96K73, Q96SN5, Q9UFR3	Gene names	FAM61A, C19orf13
Domain Architecture	No domain graphic available
Description	Protein FAM61A (Putative alpha synuclein-binding protein) (AlphaSNBP).

TEX9_MOUSE
θ value	0.813845 (rank : 71)	NC score	0.015784 (rank : 108)
Query Neighborhood Hits	148	Target Neighborhood Hits	581	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

TRPV3_MOUSE
θ value	0.813845 (rank : 72)	NC score	0.064453 (rank : 76)
Query Neighborhood Hits	148	Target Neighborhood Hits	188	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

FILA_HUMAN
θ value	1.06291 (rank : 73)	NC score	0.019847 (rank : 99)
Query Neighborhood Hits	148	Target Neighborhood Hits	685	Shared Neighborhood Hits	17
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

KCNS1_HUMAN
θ value	1.06291 (rank : 74)	NC score	0.132482 (rank : 53)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	51
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

CT2NL_HUMAN
θ value	1.38821 (rank : 75)	NC score	0.012812 (rank : 112)
Query Neighborhood Hits	148	Target Neighborhood Hits	1059	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

MY18A_MOUSE
θ value	1.38821 (rank : 76)	NC score	0.005189 (rank : 153)
Query Neighborhood Hits	148	Target Neighborhood Hits	1989	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

PKDRE_MOUSE
θ value	1.38821 (rank : 77)	NC score	0.093793 (rank : 61)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

RAI14_MOUSE
θ value	1.38821 (rank : 78)	NC score	0.005076 (rank : 154)
Query Neighborhood Hits	148	Target Neighborhood Hits	1505	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RRBP1_HUMAN
θ value	1.38821 (rank : 79)	NC score	0.012962 (rank : 111)
Query Neighborhood Hits	148	Target Neighborhood Hits	1306	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

RUFY2_HUMAN
θ value	1.38821 (rank : 80)	NC score	0.006196 (rank : 150)
Query Neighborhood Hits	148	Target Neighborhood Hits	1208	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TRPV4_HUMAN
θ value	1.38821 (rank : 81)	NC score	0.059692 (rank : 82)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	1.38821 (rank : 82)	NC score	0.061166 (rank : 80)
Query Neighborhood Hits	148	Target Neighborhood Hits	117	Shared Neighborhood Hits	24
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

NIN_HUMAN
θ value	1.81305 (rank : 83)	NC score	0.012291 (rank : 116)
Query Neighborhood Hits	148	Target Neighborhood Hits	1416	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

A16L1_MOUSE
θ value	2.36792 (rank : 84)	NC score	0.011626 (rank : 120)
Query Neighborhood Hits	148	Target Neighborhood Hits	776	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

CCNB3_MOUSE
θ value	2.36792 (rank : 85)	NC score	0.007564 (rank : 140)
Query Neighborhood Hits	148	Target Neighborhood Hits	211	Shared Neighborhood Hits	15
SwissProt Accessions	Q810T2, Q810T3, Q8VDC8	Gene names	Ccnb3, Cycb3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

GALR1_HUMAN
θ value	2.36792 (rank : 86)	NC score	-0.003647 (rank : 168)
Query Neighborhood Hits	148	Target Neighborhood Hits	862	Shared Neighborhood Hits	3
SwissProt Accessions	P47211	Gene names	GALR1, GALNR, GALNR1
Domain Architecture
Description	Galanin receptor type 1 (GAL1-R) (GALR1).

HIP1R_MOUSE
θ value	2.36792 (rank : 87)	NC score	0.013542 (rank : 109)
Query Neighborhood Hits	148	Target Neighborhood Hits	959	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

AR13B_HUMAN
θ value	3.0926 (rank : 88)	NC score	0.008457 (rank : 132)
Query Neighborhood Hits	148	Target Neighborhood Hits	528	Shared Neighborhood Hits	24
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

CCHCR_MOUSE
θ value	3.0926 (rank : 89)	NC score	0.011844 (rank : 119)
Query Neighborhood Hits	148	Target Neighborhood Hits	932	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CT2NL_MOUSE
θ value	3.0926 (rank : 90)	NC score	0.012497 (rank : 115)
Query Neighborhood Hits	148	Target Neighborhood Hits	902	Shared Neighborhood Hits	33
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

LC7L2_HUMAN
θ value	3.0926 (rank : 91)	NC score	0.018063 (rank : 105)
Query Neighborhood Hits	148	Target Neighborhood Hits	235	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y383, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1	Gene names	LUC7L2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2.

NEB1_HUMAN
θ value	3.0926 (rank : 92)	NC score	0.010528 (rank : 123)
Query Neighborhood Hits	148	Target Neighborhood Hits	829	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NIPBL_HUMAN
θ value	3.0926 (rank : 93)	NC score	0.023028 (rank : 97)
Query Neighborhood Hits	148	Target Neighborhood Hits	1311	Shared Neighborhood Hits	37
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NPBL_MOUSE
θ value	3.0926 (rank : 94)	NC score	0.027969 (rank : 95)
Query Neighborhood Hits	148	Target Neighborhood Hits	1041	Shared Neighborhood Hits	34
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PSN2_MOUSE
θ value	3.0926 (rank : 95)	NC score	0.033352 (rank : 92)
Query Neighborhood Hits	148	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

TPTE_HUMAN
θ value	3.0926 (rank : 96)	NC score	0.095318 (rank : 60)
Query Neighborhood Hits	148	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

GP73_MOUSE
θ value	4.03905 (rank : 97)	NC score	0.008392 (rank : 135)
Query Neighborhood Hits	148	Target Neighborhood Hits	506	Shared Neighborhood Hits	27
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

LC7L2_MOUSE
θ value	4.03905 (rank : 98)	NC score	0.018661 (rank : 103)
Query Neighborhood Hits	148	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TNC4, Q99LM5, Q99PC3	Gene names	Luc7l2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog).

NEK1_MOUSE
θ value	4.03905 (rank : 99)	NC score	-0.003537 (rank : 167)
Query Neighborhood Hits	148	Target Neighborhood Hits	1311	Shared Neighborhood Hits	31
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

RAD50_HUMAN
θ value	4.03905 (rank : 100)	NC score	0.007260 (rank : 141)
Query Neighborhood Hits	148	Target Neighborhood Hits	1317	Shared Neighborhood Hits	48
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

SACS_HUMAN
θ value	4.03905 (rank : 101)	NC score	0.006306 (rank : 147)
Query Neighborhood Hits	148	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

SMC2_MOUSE
θ value	4.03905 (rank : 102)	NC score	0.009938 (rank : 129)
Query Neighborhood Hits	148	Target Neighborhood Hits	1131	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

STK10_HUMAN
θ value	4.03905 (rank : 103)	NC score	0.001822 (rank : 163)
Query Neighborhood Hits	148	Target Neighborhood Hits	1921	Shared Neighborhood Hits	47
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TPR_HUMAN
θ value	4.03905 (rank : 104)	NC score	0.010172 (rank : 125)
Query Neighborhood Hits	148	Target Neighborhood Hits	1921	Shared Neighborhood Hits	62
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

BFAR_HUMAN
θ value	5.27518 (rank : 105)	NC score	0.008257 (rank : 136)
Query Neighborhood Hits	148	Target Neighborhood Hits	222	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BFAR_MOUSE
θ value	5.27518 (rank : 106)	NC score	0.008231 (rank : 138)
Query Neighborhood Hits	148	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

CCD91_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.008594 (rank : 131)
Query Neighborhood Hits	148	Target Neighborhood Hits	868	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CEP63_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.007857 (rank : 139)
Query Neighborhood Hits	148	Target Neighborhood Hits	1005	Shared Neighborhood Hits	47
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

DIAP2_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.011959 (rank : 118)
Query Neighborhood Hits	148	Target Neighborhood Hits	342	Shared Neighborhood Hits	21
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

GOGB1_HUMAN
θ value	5.27518 (rank : 110)	NC score	0.008440 (rank : 134)
Query Neighborhood Hits	148	Target Neighborhood Hits	2297	Shared Neighborhood Hits	58
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

KCNC4_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.117006 (rank : 55)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
θ value	5.27518 (rank : 112)	NC score	0.110323 (rank : 57)
Query Neighborhood Hits	148	Target Neighborhood Hits	130	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNG1_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.065355 (rank : 75)
Query Neighborhood Hits	148	Target Neighborhood Hits	103	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

MCA1_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.010422 (rank : 124)
Query Neighborhood Hits	148	Target Neighborhood Hits	86	Shared Neighborhood Hits	11
SwissProt Accessions	Q12904, Q6FG28, Q96CQ9	Gene names	SCYE1, EMAP2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

MY18A_HUMAN
θ value	5.27518 (rank : 115)	NC score	0.010018 (rank : 126)
Query Neighborhood Hits	148	Target Neighborhood Hits	1929	Shared Neighborhood Hits	57
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

SPTB2_HUMAN
θ value	5.27518 (rank : 116)	NC score	0.006381 (rank : 145)
Query Neighborhood Hits	148	Target Neighborhood Hits	748	Shared Neighborhood Hits	36
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	5.27518 (rank : 117)	NC score	0.006288 (rank : 149)
Query Neighborhood Hits	148	Target Neighborhood Hits	770	Shared Neighborhood Hits	37
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

STK10_MOUSE
θ value	5.27518 (rank : 118)	NC score	0.002135 (rank : 162)
Query Neighborhood Hits	148	Target Neighborhood Hits	2132	Shared Neighborhood Hits	56
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TMCC3_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.006725 (rank : 142)
Query Neighborhood Hits	148	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULS5, Q8IWB2	Gene names	TMCC3, KIAA1145
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 3.

CN145_MOUSE
θ value	6.88961 (rank : 120)	NC score	0.008232 (rank : 137)
Query Neighborhood Hits	148	Target Neighborhood Hits	916	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

GOGA4_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.012687 (rank : 114)
Query Neighborhood Hits	148	Target Neighborhood Hits	2034	Shared Neighborhood Hits	59
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

KCNC3_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.109281 (rank : 58)
Query Neighborhood Hits	148	Target Neighborhood Hits	256	Shared Neighborhood Hits	46
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

MCA1_MOUSE
θ value	6.88961 (rank : 123)	NC score	0.008452 (rank : 133)
Query Neighborhood Hits	148	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	P31230, Q60659	Gene names	Scye1, Emap2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

MINT_HUMAN
θ value	6.88961 (rank : 124)	NC score	0.005875 (rank : 151)
Query Neighborhood Hits	148	Target Neighborhood Hits	1291	Shared Neighborhood Hits	27
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

RBBP6_HUMAN
θ value	6.88961 (rank : 125)	NC score	0.020936 (rank : 98)
Query Neighborhood Hits	148	Target Neighborhood Hits	1135	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

SEC63_MOUSE
θ value	6.88961 (rank : 126)	NC score	0.008748 (rank : 130)
Query Neighborhood Hits	148	Target Neighborhood Hits	601	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SP17_MOUSE
θ value	6.88961 (rank : 127)	NC score	0.045655 (rank : 90)
Query Neighborhood Hits	148	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q62252	Gene names	Spa17, Sp17
Domain Architecture
Description	Sperm surface protein Sp17 (Sperm autoantigenic protein 17).

A16L1_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.006517 (rank : 144)
Query Neighborhood Hits	148	Target Neighborhood Hits	664	Shared Neighborhood Hits	29
SwissProt Accessions	Q676U5, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619	Gene names	ATG16L1, APG16L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

ARD1H_HUMAN
θ value	8.99809 (rank : 129)	NC score	0.004971 (rank : 156)
Query Neighborhood Hits	148	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41227	Gene names	ARD1A, ARD1, TE2
Domain Architecture
Description	N-terminal acetyltransferase complex ARD1 subunit homolog A (EC 2.3.1.88) (EC 2.3.1.-).

CALB2_HUMAN
θ value	8.99809 (rank : 130)	NC score	0.019225 (rank : 102)
Query Neighborhood Hits	148	Target Neighborhood Hits	149	Shared Neighborhood Hits	14
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

CALB2_MOUSE
θ value	8.99809 (rank : 131)	NC score	0.019650 (rank : 101)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	15
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

CCD45_MOUSE
θ value	8.99809 (rank : 132)	NC score	0.012113 (rank : 117)
Query Neighborhood Hits	148	Target Neighborhood Hits	663	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CP250_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.005858 (rank : 152)
Query Neighborhood Hits	148	Target Neighborhood Hits	1805	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

HMMR_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.010017 (rank : 127)
Query Neighborhood Hits	148	Target Neighborhood Hits	1082	Shared Neighborhood Hits	46
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

HOOK3_HUMAN
θ value	8.99809 (rank : 135)	NC score	0.004986 (rank : 155)
Query Neighborhood Hits	148	Target Neighborhood Hits	1070	Shared Neighborhood Hits	41
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

KCNC3_MOUSE
θ value	8.99809 (rank : 136)	NC score	0.107204 (rank : 59)
Query Neighborhood Hits	148	Target Neighborhood Hits	173	Shared Neighborhood Hits	46
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

LHX3_HUMAN
θ value	8.99809 (rank : 137)	NC score	-0.002085 (rank : 165)
Query Neighborhood Hits	148	Target Neighborhood Hits	474	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBR4, Q9NZB5, Q9P0I8, Q9P0I9	Gene names	LHX3
Domain Architecture
Description	LIM/homeobox protein Lhx3.

MARK2_HUMAN
θ value	8.99809 (rank : 138)	NC score	-0.003793 (rank : 169)
Query Neighborhood Hits	148	Target Neighborhood Hits	1056	Shared Neighborhood Hits	8
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

MYH3_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.004327 (rank : 157)
Query Neighborhood Hits	148	Target Neighborhood Hits	1660	Shared Neighborhood Hits	53
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

NELFE_MOUSE
θ value	8.99809 (rank : 140)	NC score	0.006308 (rank : 146)
Query Neighborhood Hits	148	Target Neighborhood Hits	118	Shared Neighborhood Hits	9
SwissProt Accessions	P19426, P97485, P97486, Q9CZN3	Gene names	Rdbp, D17h6s45, Nelfe, Rd
Domain Architecture
Description	Negative elongation factor E (NELF-E) (RD protein).

NELF_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.011547 (rank : 121)
Query Neighborhood Hits	148	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q6X4W1, Q6X4V7, Q6X4V8, Q6X4V9, Q8N2M2, Q96SY1, Q9NPM4, Q9NPP3, Q9NPS3	Gene names	NELF
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor).

NELF_MOUSE
θ value	8.99809 (rank : 142)	NC score	0.013172 (rank : 110)
Query Neighborhood Hits	148	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q99NF2, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1	Gene names	Nelf, Jac
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor) (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein).

NPC1_HUMAN
θ value	8.99809 (rank : 143)	NC score	0.002736 (rank : 160)
Query Neighborhood Hits	148	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

OLF9_MOUSE
θ value	8.99809 (rank : 144)	NC score	-0.001729 (rank : 164)
Query Neighborhood Hits	148	Target Neighborhood Hits	700	Shared Neighborhood Hits	10
SwissProt Accessions	Q60885, Q8VGC0	Gene names	Olfr9, Mor269-3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 9 (Olfactory receptor 269-3) (Odorant receptor M25).

PML_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.002362 (rank : 161)
Query Neighborhood Hits	148	Target Neighborhood Hits	248	Shared Neighborhood Hits	5
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

RBM6_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.004257 (rank : 158)
Query Neighborhood Hits	148	Target Neighborhood Hits	221	Shared Neighborhood Hits	9
SwissProt Accessions	P78332, O60549, O75524	Gene names	RBM6, DEF3
Domain Architecture
Description	RNA-binding protein 6 (RNA-binding motif protein 6) (RNA-binding protein DEF-3) (Lung cancer antigen NY-LU-12) (Protein G16).

SEC63_HUMAN
θ value	8.99809 (rank : 147)	NC score	0.003911 (rank : 159)
Query Neighborhood Hits	148	Target Neighborhood Hits	586	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

ZWINT_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.006577 (rank : 143)
Query Neighborhood Hits	148	Target Neighborhood Hits	333	Shared Neighborhood Hits	25
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

KCNA1_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.073353 (rank : 66)
Query Neighborhood Hits	148	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA1_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.074708 (rank : 65)
Query Neighborhood Hits	148	Target Neighborhood Hits	103	Shared Neighborhood Hits	36
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA2_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.071452 (rank : 69)
Query Neighborhood Hits	148	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA2_MOUSE
θ value	θ > 10 (rank : 152)	NC score	0.072270 (rank : 68)
Query Neighborhood Hits	148	Target Neighborhood Hits	102	Shared Neighborhood Hits	33
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA3_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.064433 (rank : 77)
Query Neighborhood Hits	148	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.063593 (rank : 79)
Query Neighborhood Hits	148	Target Neighborhood Hits	103	Shared Neighborhood Hits	29
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA4_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.051130 (rank : 88)
Query Neighborhood Hits	148	Target Neighborhood Hits	108	Shared Neighborhood Hits	24
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	θ > 10 (rank : 156)	NC score	0.051515 (rank : 87)
Query Neighborhood Hits	148	Target Neighborhood Hits	98	Shared Neighborhood Hits	24
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA5_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.061050 (rank : 81)
Query Neighborhood Hits	148	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	θ > 10 (rank : 158)	NC score	0.065848 (rank : 74)
Query Neighborhood Hits	148	Target Neighborhood Hits	119	Shared Neighborhood Hits	33
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA6_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.066469 (rank : 73)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA6_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.069219 (rank : 72)
Query Neighborhood Hits	148	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG2_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.058675 (rank : 83)
Query Neighborhood Hits	148	Target Neighborhood Hits	83	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG3_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.085156 (rank : 64)
Query Neighborhood Hits	148	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.085543 (rank : 63)
Query Neighborhood Hits	148	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG4_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.057290 (rank : 85)
Query Neighborhood Hits	148	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.056032 (rank : 86)
Query Neighborhood Hits	148	Target Neighborhood Hits	99	Shared Neighborhood Hits	29
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ1_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.064273 (rank : 78)
Query Neighborhood Hits	148	Target Neighborhood Hits	175	Shared Neighborhood Hits	33
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ4_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.072293 (rank : 67)
Query Neighborhood Hits	148	Target Neighborhood Hits	136	Shared Neighborhood Hits	36
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNQ5_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.050356 (rank : 89)
Query Neighborhood Hits	148	Target Neighborhood Hits	163	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

KCNS1_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.114053 (rank : 56)
Query Neighborhood Hits	148	Target Neighborhood Hits	114	Shared Neighborhood Hits	45
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

Hits sorted by NC score

SCN1A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	148
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
NC score	0.997105 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	148	Target Neighborhood Hits	157	Shared Neighborhood Hits	95
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
NC score	0.996482 (rank : 3)	θ value	0 (rank : 7)
Query Neighborhood Hits	148	Target Neighborhood Hits	115	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN8A_MOUSE
NC score	0.995339 (rank : 4)	θ value	0 (rank : 12)
Query Neighborhood Hits	148	Target Neighborhood Hits	136	Shared Neighborhood Hits	87
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN9A_HUMAN
NC score	0.994925 (rank : 5)	θ value	0 (rank : 13)
Query Neighborhood Hits	148	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN8A_HUMAN
NC score	0.994527 (rank : 6)	θ value	0 (rank : 11)
Query Neighborhood Hits	148	Target Neighborhood Hits	135	Shared Neighborhood Hits	83
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SC10A_HUMAN
NC score	0.992373 (rank : 7)	θ value	0 (rank : 1)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	67
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
NC score	0.991929 (rank : 8)	θ value	0 (rank : 2)
Query Neighborhood Hits	148	Target Neighborhood Hits	107	Shared Neighborhood Hits	66
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN4A_HUMAN
NC score	0.991367 (rank : 9)	θ value	0 (rank : 8)
Query Neighborhood Hits	148	Target Neighborhood Hits	133	Shared Neighborhood Hits	70
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
NC score	0.986532 (rank : 10)	θ value	0 (rank : 9)
Query Neighborhood Hits	148	Target Neighborhood Hits	145	Shared Neighborhood Hits	72
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN7A_HUMAN
NC score	0.985313 (rank : 11)	θ value	0 (rank : 10)
Query Neighborhood Hits	148	Target Neighborhood Hits	135	Shared Neighborhood Hits	56
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SC11A_MOUSE
NC score	0.984738 (rank : 12)	θ value	0 (rank : 4)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	68
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC11A_HUMAN
NC score	0.983180 (rank : 13)	θ value	0 (rank : 3)
Query Neighborhood Hits	148	Target Neighborhood Hits	111	Shared Neighborhood Hits	65
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

CAC1I_HUMAN
NC score	0.893084 (rank : 14)	θ value	3.57772e-73 (rank : 16)
Query Neighborhood Hits	148	Target Neighborhood Hits	138	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.872736 (rank : 15)	θ value	1.66191e-70 (rank : 19)
Query Neighborhood Hits	148	Target Neighborhood Hits	230	Shared Neighborhood Hits	61
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.865624 (rank : 16)	θ value	3.13423e-69 (rank : 22)
Query Neighborhood Hits	148	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1E_MOUSE
NC score	0.855745 (rank : 17)	θ value	4.09345e-69 (rank : 23)
Query Neighborhood Hits	148	Target Neighborhood Hits	167	Shared Neighborhood Hits	66
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.855226 (rank : 18)	θ value	3.13423e-69 (rank : 21)
Query Neighborhood Hits	148	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1A_MOUSE
NC score	0.851868 (rank : 19)	θ value	4.99229e-75 (rank : 14)
Query Neighborhood Hits	148	Target Neighborhood Hits	267	Shared Neighborhood Hits	63
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1G_HUMAN
NC score	0.849262 (rank : 20)	θ value	3.70236e-70 (rank : 20)
Query Neighborhood Hits	148	Target Neighborhood Hits	587	Shared Neighborhood Hits	59
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1B_HUMAN
NC score	0.844847 (rank : 21)	θ value	1.11475e-66 (rank : 26)
Query Neighborhood Hits	148	Target Neighborhood Hits	257	Shared Neighborhood Hits	60
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_MOUSE
NC score	0.844435 (rank : 22)	θ value	9.11921e-69 (rank : 24)
Query Neighborhood Hits	148	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1A_HUMAN
NC score	0.844102 (rank : 23)	θ value	1.11217e-74 (rank : 15)
Query Neighborhood Hits	148	Target Neighborhood Hits	387	Shared Neighborhood Hits	66
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1D_HUMAN
NC score	0.843867 (rank : 24)	θ value	1.96316e-71 (rank : 17)
Query Neighborhood Hits	148	Target Neighborhood Hits	118	Shared Neighborhood Hits	60
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1S_HUMAN
NC score	0.843179 (rank : 25)	θ value	6.53529e-67 (rank : 25)
Query Neighborhood Hits	148	Target Neighborhood Hits	92	Shared Neighborhood Hits	55
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_MOUSE
NC score	0.841975 (rank : 26)	θ value	1.66191e-70 (rank : 18)
Query Neighborhood Hits	148	Target Neighborhood Hits	351	Shared Neighborhood Hits	61
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_MOUSE
NC score	0.838548 (rank : 27)	θ value	2.56992e-63 (rank : 29)
Query Neighborhood Hits	148	Target Neighborhood Hits	142	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.837717 (rank : 28)	θ value	1.50663e-63 (rank : 28)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	61
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.836675 (rank : 29)	θ value	1.36269e-64 (rank : 27)
Query Neighborhood Hits	148	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.831669 (rank : 30)	θ value	5.92465e-60 (rank : 30)
Query Neighborhood Hits	148	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PK2L2_HUMAN
NC score	0.304278 (rank : 31)	θ value	0.0113563 (rank : 41)
Query Neighborhood Hits	148	Target Neighborhood Hits	90	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.282681 (rank : 32)	θ value	0.00665767 (rank : 37)
Query Neighborhood Hits	148	Target Neighborhood Hits	132	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.269667 (rank : 33)	θ value	0.0113563 (rank : 42)
Query Neighborhood Hits	148	Target Neighborhood Hits	84	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_MOUSE
NC score	0.265334 (rank : 34)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	148	Target Neighborhood Hits	99	Shared Neighborhood Hits	47
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
NC score	0.262004 (rank : 35)	θ value	0.00665767 (rank : 38)
Query Neighborhood Hits	148	Target Neighborhood Hits	105	Shared Neighborhood Hits	45
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNF1_HUMAN
NC score	0.224962 (rank : 36)	θ value	7.1131e-05 (rank : 32)
Query Neighborhood Hits	148	Target Neighborhood Hits	109	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNB2_HUMAN
NC score	0.209533 (rank : 37)	θ value	1.09739e-05 (rank : 31)
Query Neighborhood Hits	148	Target Neighborhood Hits	212	Shared Neighborhood Hits	54
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNV2_HUMAN
NC score	0.208234 (rank : 38)	θ value	0.0113563 (rank : 40)
Query Neighborhood Hits	148	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNS2_MOUSE
NC score	0.199956 (rank : 39)	θ value	0.0148317 (rank : 43)
Query Neighborhood Hits	148	Target Neighborhood Hits	130	Shared Neighborhood Hits	53
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
NC score	0.194669 (rank : 40)	θ value	0.0252991 (rank : 51)
Query Neighborhood Hits	148	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_MOUSE
NC score	0.189668 (rank : 41)	θ value	0.00035302 (rank : 34)
Query Neighborhood Hits	148	Target Neighborhood Hits	154	Shared Neighborhood Hits	53
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNB1_HUMAN
NC score	0.189575 (rank : 42)	θ value	0.00035302 (rank : 33)
Query Neighborhood Hits	148	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCND3_MOUSE
NC score	0.170740 (rank : 43)	θ value	0.00509761 (rank : 36)
Query Neighborhood Hits	148	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.170625 (rank : 44)	θ value	0.00509761 (rank : 35)
Query Neighborhood Hits	148	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
NC score	0.168405 (rank : 45)	θ value	0.0252991 (rank : 52)
Query Neighborhood Hits	148	Target Neighborhood Hits	125	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND2_MOUSE
NC score	0.163247 (rank : 46)	θ value	0.0252991 (rank : 50)
Query Neighborhood Hits	148	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.163081 (rank : 47)	θ value	0.0252991 (rank : 49)
Query Neighborhood Hits	148	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.144689 (rank : 48)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	148	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.142930 (rank : 49)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	148	Target Neighborhood Hits	160	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

TPTE2_HUMAN
NC score	0.139556 (rank : 50)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	148	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNC1_HUMAN
NC score	0.136618 (rank : 51)	θ value	0.0193708 (rank : 46)
Query Neighborhood Hits	148	Target Neighborhood Hits	133	Shared Neighborhood Hits	48
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
NC score	0.134289 (rank : 52)	θ value	0.0252991 (rank : 48)
Query Neighborhood Hits	148	Target Neighborhood Hits	133	Shared Neighborhood Hits	48
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNS1_HUMAN
NC score	0.132482 (rank : 53)	θ value	1.06291 (rank : 74)
Query Neighborhood Hits	148	Target Neighborhood Hits	116	Shared Neighborhood Hits	51
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

PKDRE_HUMAN
NC score	0.119512 (rank : 54)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	148	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNC4_HUMAN
NC score	0.117006 (rank : 55)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNS1_MOUSE
NC score	0.114053 (rank : 56)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	148	Target Neighborhood Hits	114	Shared Neighborhood Hits	45
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC4_MOUSE
NC score	0.110323 (rank : 57)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	148	Target Neighborhood Hits	130	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNC3_HUMAN
NC score	0.109281 (rank : 58)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	148	Target Neighborhood Hits	256	Shared Neighborhood Hits	46
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
NC score	0.107204 (rank : 59)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	148	Target Neighborhood Hits	173	Shared Neighborhood Hits	46
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

TPTE_HUMAN
NC score	0.095318 (rank : 60)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	148	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

PKDRE_MOUSE
NC score	0.093793 (rank : 61)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	148	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TRPV3_HUMAN
NC score	0.092997 (rank : 62)	θ value	0.163984 (rank : 61)
Query Neighborhood Hits	148	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

KCNG3_MOUSE
NC score	0.085543 (rank : 63)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	148	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_HUMAN
NC score	0.085156 (rank : 64)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	148	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNA1_MOUSE
NC score	0.074708 (rank : 65)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	148	Target Neighborhood Hits	103	Shared Neighborhood Hits	36
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA1_HUMAN
NC score	0.073353 (rank : 66)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	148	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNQ4_HUMAN
NC score	0.072293 (rank : 67)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	148	Target Neighborhood Hits	136	Shared Neighborhood Hits	36
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNA2_MOUSE
NC score	0.072270 (rank : 68)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	148	Target Neighborhood Hits	102	Shared Neighborhood Hits	33
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA2_HUMAN
NC score	0.071452 (rank : 69)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	148	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

TRPC1_MOUSE
NC score	0.070580 (rank : 70)	θ value	0.0148317 (rank : 45)
Query Neighborhood Hits	148	Target Neighborhood Hits	87	Shared Neighborhood Hits	18
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.070510 (rank : 71)	θ value	0.0148317 (rank : 44)
Query Neighborhood Hits	148	Target Neighborhood Hits	91	Shared Neighborhood Hits	18
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

KCNA6_MOUSE
NC score	0.069219 (rank : 72)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	148	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNA6_HUMAN
NC score	0.066469 (rank : 73)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	148	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA5_MOUSE
NC score	0.065848 (rank : 74)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	148	Target Neighborhood Hits	119	Shared Neighborhood Hits	33
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNG1_HUMAN
NC score	0.065355 (rank : 75)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	148	Target Neighborhood Hits	103	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

TRPV3_MOUSE
NC score	0.064453 (rank : 76)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	148	Target Neighborhood Hits	188	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

KCNA3_HUMAN
NC score	0.064433 (rank : 77)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	148	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNQ1_MOUSE
NC score	0.064273 (rank : 78)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	148	Target Neighborhood Hits	175	Shared Neighborhood Hits	33
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA3_MOUSE
NC score	0.063593 (rank : 79)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	148	Target Neighborhood Hits	103	Shared Neighborhood Hits	29
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

TRPV4_MOUSE
NC score	0.061166 (rank : 80)	θ value	1.38821 (rank : 82)
Query Neighborhood Hits	148	Target Neighborhood Hits	117	Shared Neighborhood Hits	24
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

KCNA5_HUMAN
NC score	0.061050 (rank : 81)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	148	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

TRPV4_HUMAN
NC score	0.059692 (rank : 82)	θ value	1.38821 (rank : 81)
Query Neighborhood Hits	148	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

KCNG2_HUMAN
NC score	0.058675 (rank : 83)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	148	Target Neighborhood Hits	83	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

CABP5_MOUSE
NC score	0.058212 (rank : 84)	θ value	0.163984 (rank : 58)
Query Neighborhood Hits	148	Target Neighborhood Hits	207	Shared Neighborhood Hits	16
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KCNG4_HUMAN
NC score	0.057290 (rank : 85)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	148	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
NC score	0.056032 (rank : 86)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	148	Target Neighborhood Hits	99	Shared Neighborhood Hits	29
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA4_MOUSE
NC score	0.051515 (rank : 87)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	148	Target Neighborhood Hits	98	Shared Neighborhood Hits	24
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA4_HUMAN
NC score	0.051130 (rank : 88)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	148	Target Neighborhood Hits	108	Shared Neighborhood Hits	24
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNQ5_HUMAN
NC score	0.050356 (rank : 89)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	148	Target Neighborhood Hits	163	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

SP17_MOUSE
NC score	0.045655 (rank : 90)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	148	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q62252	Gene names	Spa17, Sp17
Domain Architecture
Description	Sperm surface protein Sp17 (Sperm autoantigenic protein 17).

CABP5_HUMAN
NC score	0.042478 (rank : 91)	θ value	0.62314 (rank : 67)
Query Neighborhood Hits	148	Target Neighborhood Hits	197	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

PSN2_MOUSE
NC score	0.033352 (rank : 92)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	148	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

IWS1_MOUSE
NC score	0.031866 (rank : 93)	θ value	0.0113563 (rank : 39)
Query Neighborhood Hits	148	Target Neighborhood Hits	1258	Shared Neighborhood Hits	34
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

RBBP6_MOUSE
NC score	0.028676 (rank : 94)	θ value	0.0252991 (rank : 53)
Query Neighborhood Hits	148	Target Neighborhood Hits	1014	Shared Neighborhood Hits	31
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

NPBL_MOUSE
NC score	0.027969 (rank : 95)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	148	Target Neighborhood Hits	1041	Shared Neighborhood Hits	34
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

IMMT_HUMAN
NC score	0.025932 (rank : 96)	θ value	0.0563607 (rank : 54)
Query Neighborhood Hits	148	Target Neighborhood Hits	494	Shared Neighborhood Hits	29
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

NIPBL_HUMAN
NC score	0.023028 (rank : 97)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	148	Target Neighborhood Hits	1311	Shared Neighborhood Hits	37
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

RBBP6_HUMAN
NC score	0.020936 (rank : 98)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	148	Target Neighborhood Hits	1135	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

FILA_HUMAN
NC score	0.019847 (rank : 99)	θ value	1.06291 (rank : 73)
Query Neighborhood Hits	148	Target Neighborhood Hits	685	Shared Neighborhood Hits	17
SwissProt Accessions	P20930, Q01720, Q5T583	Gene names	FLG
Domain Architecture	No domain graphic available
Description	Filaggrin.

KMHN1_MOUSE
NC score	0.019823 (rank : 100)	θ value	0.0736092 (rank : 56)
Query Neighborhood Hits	148	Target Neighborhood Hits	949	Shared Neighborhood Hits	41
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

CALB2_MOUSE
NC score	0.019650 (rank : 101)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	148	Target Neighborhood Hits	141	Shared Neighborhood Hits	15
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

CALB2_HUMAN
NC score	0.019225 (rank : 102)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	148	Target Neighborhood Hits	149	Shared Neighborhood Hits	14
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

LC7L2_MOUSE
NC score	0.018661 (rank : 103)	θ value	4.03905 (rank : 98)
Query Neighborhood Hits	148	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	Q7TNC4, Q99LM5, Q99PC3	Gene names	Luc7l2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2 (CGI-74 homolog).

CK5P2_HUMAN
NC score	0.018526 (rank : 104)	θ value	0.0252991 (rank : 47)
Query Neighborhood Hits	148	Target Neighborhood Hits	1433	Shared Neighborhood Hits	52
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

LC7L2_HUMAN
NC score	0.018063 (rank : 105)	θ value	3.0926 (rank : 91)
Query Neighborhood Hits	148	Target Neighborhood Hits	235	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y383, Q8IUP9, Q9NVL3, Q9NVN7, Q9UQN1	Gene names	LUC7L2
Domain Architecture
Description	Putative RNA-binding protein Luc7-like 2.

GLE1_MOUSE
NC score	0.017782 (rank : 106)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	148	Target Neighborhood Hits	504	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

GOGA2_MOUSE
NC score	0.017137 (rank : 107)	θ value	0.62314 (rank : 68)
Query Neighborhood Hits	148	Target Neighborhood Hits	944	Shared Neighborhood Hits	44
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

TEX9_MOUSE
NC score	0.015784 (rank : 108)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	148	Target Neighborhood Hits	581	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

HIP1R_MOUSE
NC score	0.013542 (rank : 109)	θ value	2.36792 (rank : 87)
Query Neighborhood Hits	148	Target Neighborhood Hits	959	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

NELF_MOUSE
NC score	0.013172 (rank : 110)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	148	Target Neighborhood Hits	35	Shared Neighborhood Hits	5
SwissProt Accessions	Q99NF2, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1	Gene names	Nelf, Jac
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor) (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein).

RRBP1_HUMAN
NC score	0.012962 (rank : 111)	θ value	1.38821 (rank : 79)
Query Neighborhood Hits	148	Target Neighborhood Hits	1306	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

CT2NL_HUMAN
NC score	0.012812 (rank : 112)	θ value	1.38821 (rank : 75)
Query Neighborhood Hits	148	Target Neighborhood Hits	1059	Shared Neighborhood Hits	41
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

FA61A_HUMAN
NC score	0.012788 (rank : 113)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	148	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q8ND56, Q76LX7, Q96AR3, Q96K73, Q96SN5, Q9UFR3	Gene names	FAM61A, C19orf13
Domain Architecture	No domain graphic available
Description	Protein FAM61A (Putative alpha synuclein-binding protein) (AlphaSNBP).

GOGA4_HUMAN
NC score	0.012687 (rank : 114)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	148	Target Neighborhood Hits	2034	Shared Neighborhood Hits	59
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

CT2NL_MOUSE
NC score	0.012497 (rank : 115)	θ value	3.0926 (rank : 90)
Query Neighborhood Hits	148	Target Neighborhood Hits	902	Shared Neighborhood Hits	33
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

NIN_HUMAN
NC score	0.012291 (rank : 116)	θ value	1.81305 (rank : 83)
Query Neighborhood Hits	148	Target Neighborhood Hits	1416	Shared Neighborhood Hits	52
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

CCD45_MOUSE
NC score	0.012113 (rank : 117)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	148	Target Neighborhood Hits	663	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

DIAP2_HUMAN
NC score	0.011959 (rank : 118)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	148	Target Neighborhood Hits	342	Shared Neighborhood Hits	21
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

CCHCR_MOUSE
NC score	0.011844 (rank : 119)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	148	Target Neighborhood Hits	932	Shared Neighborhood Hits	42
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

A16L1_MOUSE
NC score	0.011626 (rank : 120)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	148	Target Neighborhood Hits	776	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

NELF_HUMAN
NC score	0.011547 (rank : 121)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	148	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q6X4W1, Q6X4V7, Q6X4V8, Q6X4V9, Q8N2M2, Q96SY1, Q9NPM4, Q9NPP3, Q9NPS3	Gene names	NELF
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor).

DDX49_HUMAN
NC score	0.011151 (rank : 122)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	148	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

NEB1_HUMAN
NC score	0.010528 (rank : 123)	θ value	3.0926 (rank : 92)
Query Neighborhood Hits	148	Target Neighborhood Hits	829	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

MCA1_HUMAN
NC score	0.010422 (rank : 124)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	148	Target Neighborhood Hits	86	Shared Neighborhood Hits	11
SwissProt Accessions	Q12904, Q6FG28, Q96CQ9	Gene names	SCYE1, EMAP2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

TPR_HUMAN
NC score	0.010172 (rank : 125)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	148	Target Neighborhood Hits	1921	Shared Neighborhood Hits	62
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

MY18A_HUMAN
NC score	0.010018 (rank : 126)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	148	Target Neighborhood Hits	1929	Shared Neighborhood Hits	57
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

HMMR_HUMAN
NC score	0.010017 (rank : 127)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	148	Target Neighborhood Hits	1082	Shared Neighborhood Hits	46
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

GOGA4_MOUSE
NC score	0.010016 (rank : 128)	θ value	0.0736092 (rank : 55)
Query Neighborhood Hits	148	Target Neighborhood Hits	1939	Shared Neighborhood Hits	53
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

SMC2_MOUSE
NC score	0.009938 (rank : 129)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	148	Target Neighborhood Hits	1131	Shared Neighborhood Hits	45
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SEC63_MOUSE
NC score	0.008748 (rank : 130)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	148	Target Neighborhood Hits	601	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

CCD91_HUMAN
NC score	0.008594 (rank : 131)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	148	Target Neighborhood Hits	868	Shared Neighborhood Hits	41
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

AR13B_HUMAN
NC score	0.008457 (rank : 132)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	148	Target Neighborhood Hits	528	Shared Neighborhood Hits	24
SwissProt Accessions	Q3SXY8, Q504W8	Gene names	ARL13B, ARL2L1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-like protein 13B (ADP-ribosylation factor-like protein 2-like 1) (ARL2-like protein 1).

MCA1_MOUSE
NC score	0.008452 (rank : 133)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	148	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	P31230, Q60659	Gene names	Scye1, Emap2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

GOGB1_HUMAN
NC score	0.008440 (rank : 134)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	148	Target Neighborhood Hits	2297	Shared Neighborhood Hits	58
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

GP73_MOUSE
NC score	0.008392 (rank : 135)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	148	Target Neighborhood Hits	506	Shared Neighborhood Hits	27
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

BFAR_HUMAN
NC score	0.008257 (rank : 136)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	148	Target Neighborhood Hits	222	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

CN145_MOUSE
NC score	0.008232 (rank : 137)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	148	Target Neighborhood Hits	916	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

BFAR_MOUSE
NC score	0.008231 (rank : 138)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	148	Target Neighborhood Hits	232	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

CEP63_HUMAN
NC score	0.007857 (rank : 139)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	148	Target Neighborhood Hits	1005	Shared Neighborhood Hits	47
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CCNB3_MOUSE
NC score	0.007564 (rank : 140)	θ value	2.36792 (rank : 85)
Query Neighborhood Hits	148	Target Neighborhood Hits	211	Shared Neighborhood Hits	15
SwissProt Accessions	Q810T2, Q810T3, Q8VDC8	Gene names	Ccnb3, Cycb3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

RAD50_HUMAN
NC score	0.007260 (rank : 141)	θ value	4.03905 (rank : 100)
Query Neighborhood Hits	148	Target Neighborhood Hits	1317	Shared Neighborhood Hits	48
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

TMCC3_HUMAN
NC score	0.006725 (rank : 142)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	148	Target Neighborhood Hits	202	Shared Neighborhood Hits	16
SwissProt Accessions	Q9ULS5, Q8IWB2	Gene names	TMCC3, KIAA1145
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 3.

ZWINT_HUMAN
NC score	0.006577 (rank : 143)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	148	Target Neighborhood Hits	333	Shared Neighborhood Hits	25
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

A16L1_HUMAN
NC score	0.006517 (rank : 144)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	148	Target Neighborhood Hits	664	Shared Neighborhood Hits	29
SwissProt Accessions	Q676U5, Q6IPN1, Q6UXW4, Q6ZVZ5, Q8NCY2, Q96JV5, Q9H619	Gene names	ATG16L1, APG16L
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

SPTB2_HUMAN
NC score	0.006381 (rank : 145)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	148	Target Neighborhood Hits	748	Shared Neighborhood Hits	36
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

NELFE_MOUSE
NC score	0.006308 (rank : 146)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	148	Target Neighborhood Hits	118	Shared Neighborhood Hits	9
SwissProt Accessions	P19426, P97485, P97486, Q9CZN3	Gene names	Rdbp, D17h6s45, Nelfe, Rd
Domain Architecture
Description	Negative elongation factor E (NELF-E) (RD protein).

SACS_HUMAN
NC score	0.006306 (rank : 147)	θ value	4.03905 (rank : 101)
Query Neighborhood Hits	148	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZJ4, O94835	Gene names	SACS, KIAA0730
Domain Architecture
Description	Sacsin.

LAMC2_HUMAN
NC score	0.006295 (rank : 148)	θ value	0.21417 (rank : 62)
Query Neighborhood Hits	148	Target Neighborhood Hits	715	Shared Neighborhood Hits	24
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

SPTB2_MOUSE
NC score	0.006288 (rank : 149)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	148	Target Neighborhood Hits	770	Shared Neighborhood Hits	37
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

RUFY2_HUMAN
NC score	0.006196 (rank : 150)	θ value	1.38821 (rank : 80)
Query Neighborhood Hits	148	Target Neighborhood Hits	1208	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

MINT_HUMAN
NC score	0.005875 (rank : 151)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	148	Target Neighborhood Hits	1291	Shared Neighborhood Hits	27
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

CP250_HUMAN
NC score	0.005858 (rank : 152)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	148	Target Neighborhood Hits	1805	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

MY18A_MOUSE
NC score	0.005189 (rank : 153)	θ value	1.38821 (rank : 76)
Query Neighborhood Hits	148	Target Neighborhood Hits	1989	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RAI14_MOUSE
NC score	0.005076 (rank : 154)	θ value	1.38821 (rank : 78)
Query Neighborhood Hits	148	Target Neighborhood Hits	1505	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

HOOK3_HUMAN
NC score	0.004986 (rank : 155)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	148	Target Neighborhood Hits	1070	Shared Neighborhood Hits	41
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

ARD1H_HUMAN
NC score	0.004971 (rank : 156)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	148	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	P41227	Gene names	ARD1A, ARD1, TE2
Domain Architecture
Description	N-terminal acetyltransferase complex ARD1 subunit homolog A (EC 2.3.1.88) (EC 2.3.1.-).

MYH3_HUMAN
NC score	0.004327 (rank : 157)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	148	Target Neighborhood Hits	1660	Shared Neighborhood Hits	53
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

RBM6_HUMAN
NC score	0.004257 (rank : 158)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	148	Target Neighborhood Hits	221	Shared Neighborhood Hits	9
SwissProt Accessions	P78332, O60549, O75524	Gene names	RBM6, DEF3
Domain Architecture
Description	RNA-binding protein 6 (RNA-binding motif protein 6) (RNA-binding protein DEF-3) (Lung cancer antigen NY-LU-12) (Protein G16).

SEC63_HUMAN
NC score	0.003911 (rank : 159)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	148	Target Neighborhood Hits	586	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UGP8, O95380, Q86VS9, Q8IWL0, Q9NTE0	Gene names	SEC63, SEC63L
Domain Architecture
Description	Translocation protein SEC63 homolog.

NPC1_HUMAN
NC score	0.002736 (rank : 160)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	148	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

PML_HUMAN
NC score	0.002362 (rank : 161)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	148	Target Neighborhood Hits	248	Shared Neighborhood Hits	5
SwissProt Accessions	P29590, P29591, P29592, P29593, Q00755	Gene names	PML, MYL, RNF71, TRIM19
Domain Architecture
Description	Probable transcription factor PML (Tripartite motif-containing protein 19) (RING finger protein 71).

STK10_MOUSE
NC score	0.002135 (rank : 162)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	148	Target Neighborhood Hits	2132	Shared Neighborhood Hits	56
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_HUMAN
NC score	0.001822 (rank : 163)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	148	Target Neighborhood Hits	1921	Shared Neighborhood Hits	47
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

OLF9_MOUSE
NC score	-0.001729 (rank : 164)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	148	Target Neighborhood Hits	700	Shared Neighborhood Hits	10
SwissProt Accessions	Q60885, Q8VGC0	Gene names	Olfr9, Mor269-3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 9 (Olfactory receptor 269-3) (Odorant receptor M25).

LHX3_HUMAN
NC score	-0.002085 (rank : 165)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	148	Target Neighborhood Hits	474	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UBR4, Q9NZB5, Q9P0I8, Q9P0I9	Gene names	LHX3
Domain Architecture
Description	LIM/homeobox protein Lhx3.

MARK2_MOUSE
NC score	-0.002525 (rank : 166)	θ value	0.163984 (rank : 60)
Query Neighborhood Hits	148	Target Neighborhood Hits	1018	Shared Neighborhood Hits	8
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

NEK1_MOUSE
NC score	-0.003537 (rank : 167)	θ value	4.03905 (rank : 99)
Query Neighborhood Hits	148	Target Neighborhood Hits	1311	Shared Neighborhood Hits	31
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

GALR1_HUMAN
NC score	-0.003647 (rank : 168)	θ value	2.36792 (rank : 86)
Query Neighborhood Hits	148	Target Neighborhood Hits	862	Shared Neighborhood Hits	3
SwissProt Accessions	P47211	Gene names	GALR1, GALNR, GALNR1
Domain Architecture
Description	Galanin receptor type 1 (GAL1-R) (GALR1).

MARK2_HUMAN
NC score	-0.003793 (rank : 169)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	148	Target Neighborhood Hits	1056	Shared Neighborhood Hits	8
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).