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Network neighborhood for query Sequence : SCN9A_HUMAN

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SCN9A_HUMAN
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SC10A_HUMAN
θ value	0 (rank : 1)	NC score	0.991707 (rank : 8)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
θ value	0 (rank : 2)	NC score	0.991771 (rank : 7)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	69
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC11A_HUMAN
θ value	0 (rank : 3)	NC score	0.982985 (rank : 13)
Query Neighborhood Hits	157	Target Neighborhood Hits	111	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC11A_MOUSE
θ value	0 (rank : 4)	NC score	0.984696 (rank : 12)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN1A_HUMAN
θ value	0 (rank : 5)	NC score	0.994925 (rank : 4)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	79
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0 (rank : 6)	NC score	0.995157 (rank : 3)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
θ value	0 (rank : 7)	NC score	0.995789 (rank : 2)
Query Neighborhood Hits	157	Target Neighborhood Hits	115	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
θ value	0 (rank : 8)	NC score	0.990950 (rank : 9)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	74
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
θ value	0 (rank : 9)	NC score	0.985736 (rank : 10)
Query Neighborhood Hits	157	Target Neighborhood Hits	145	Shared Neighborhood Hits	76
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN7A_HUMAN
θ value	0 (rank : 10)	NC score	0.985220 (rank : 11)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	59
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN8A_HUMAN
θ value	0 (rank : 11)	NC score	0.993884 (rank : 6)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	0 (rank : 12)	NC score	0.994332 (rank : 5)
Query Neighborhood Hits	157	Target Neighborhood Hits	136	Shared Neighborhood Hits	76
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN9A_HUMAN
θ value	0 (rank : 13)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	157
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

CAC1I_HUMAN
θ value	1.31376e-75 (rank : 14)	NC score	0.893607 (rank : 14)
Query Neighborhood Hits	157	Target Neighborhood Hits	138	Shared Neighborhood Hits	63
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1A_MOUSE
θ value	1.60597e-73 (rank : 15)	NC score	0.851713 (rank : 19)
Query Neighborhood Hits	157	Target Neighborhood Hits	267	Shared Neighborhood Hits	61
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1D_HUMAN
θ value	1.35953e-72 (rank : 16)	NC score	0.845888 (rank : 22)
Query Neighborhood Hits	157	Target Neighborhood Hits	118	Shared Neighborhood Hits	61
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1A_HUMAN
θ value	5.1662e-72 (rank : 17)	NC score	0.843979 (rank : 25)
Query Neighborhood Hits	157	Target Neighborhood Hits	387	Shared Neighborhood Hits	62
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1H_MOUSE
θ value	6.7473e-72 (rank : 18)	NC score	0.872989 (rank : 15)
Query Neighborhood Hits	157	Target Neighborhood Hits	230	Shared Neighborhood Hits	63
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1S_MOUSE
θ value	8.81223e-72 (rank : 19)	NC score	0.846393 (rank : 21)
Query Neighborhood Hits	157	Target Neighborhood Hits	98	Shared Neighborhood Hits	59
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_MOUSE
θ value	1.96316e-71 (rank : 20)	NC score	0.842207 (rank : 26)
Query Neighborhood Hits	157	Target Neighborhood Hits	351	Shared Neighborhood Hits	59
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1H_HUMAN
θ value	1.66191e-70 (rank : 21)	NC score	0.866034 (rank : 16)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	63
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1E_HUMAN
θ value	2.83479e-70 (rank : 22)	NC score	0.855635 (rank : 18)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1F_MOUSE
θ value	3.70236e-70 (rank : 23)	NC score	0.841119 (rank : 27)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1E_MOUSE
θ value	4.83544e-70 (rank : 24)	NC score	0.856030 (rank : 17)
Query Neighborhood Hits	157	Target Neighborhood Hits	167	Shared Neighborhood Hits	63
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1F_HUMAN
θ value	4.83544e-70 (rank : 25)	NC score	0.840279 (rank : 28)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	61
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_HUMAN
θ value	3.13423e-69 (rank : 26)	NC score	0.845106 (rank : 23)
Query Neighborhood Hits	157	Target Neighborhood Hits	92	Shared Neighborhood Hits	56
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1C_MOUSE
θ value	3.4653e-68 (rank : 27)	NC score	0.838679 (rank : 29)
Query Neighborhood Hits	157	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1G_HUMAN
θ value	1.00825e-67 (rank : 28)	NC score	0.848899 (rank : 20)
Query Neighborhood Hits	157	Target Neighborhood Hits	587	Shared Neighborhood Hits	61
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1B_HUMAN
θ value	3.83135e-67 (rank : 29)	NC score	0.845017 (rank : 24)
Query Neighborhood Hits	157	Target Neighborhood Hits	257	Shared Neighborhood Hits	57
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1C_HUMAN
θ value	1.04338e-64 (rank : 30)	NC score	0.833834 (rank : 30)
Query Neighborhood Hits	157	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

KCNB2_HUMAN
θ value	9.29e-05 (rank : 31)	NC score	0.216165 (rank : 37)
Query Neighborhood Hits	157	Target Neighborhood Hits	212	Shared Neighborhood Hits	57
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNB1_HUMAN
θ value	0.000158464 (rank : 32)	NC score	0.196508 (rank : 42)
Query Neighborhood Hits	157	Target Neighborhood Hits	169	Shared Neighborhood Hits	56
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	0.000158464 (rank : 33)	NC score	0.196544 (rank : 41)
Query Neighborhood Hits	157	Target Neighborhood Hits	154	Shared Neighborhood Hits	56
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

PK2L2_HUMAN
θ value	0.000158464 (rank : 34)	NC score	0.309094 (rank : 31)
Query Neighborhood Hits	157	Target Neighborhood Hits	90	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
θ value	0.000602161 (rank : 35)	NC score	0.274068 (rank : 33)
Query Neighborhood Hits	157	Target Neighborhood Hits	84	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

KCNF1_HUMAN
θ value	0.00175202 (rank : 36)	NC score	0.231756 (rank : 36)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNS2_MOUSE
θ value	0.00175202 (rank : 37)	NC score	0.207499 (rank : 39)
Query Neighborhood Hits	157	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
θ value	0.00298849 (rank : 38)	NC score	0.202245 (rank : 40)
Query Neighborhood Hits	157	Target Neighborhood Hits	129	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNV2_HUMAN
θ value	0.00298849 (rank : 39)	NC score	0.215412 (rank : 38)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCND2_HUMAN
θ value	0.00509761 (rank : 40)	NC score	0.170337 (rank : 47)
Query Neighborhood Hits	157	Target Neighborhood Hits	154	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.00509761 (rank : 41)	NC score	0.170500 (rank : 46)
Query Neighborhood Hits	157	Target Neighborhood Hits	156	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

SMC2_HUMAN
θ value	0.00509761 (rank : 42)	NC score	0.018691 (rank : 101)
Query Neighborhood Hits	157	Target Neighborhood Hits	1405	Shared Neighborhood Hits	38
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

PKD2_HUMAN
θ value	0.00869519 (rank : 43)	NC score	0.264411 (rank : 35)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	43
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

GCC2_HUMAN
θ value	0.0113563 (rank : 44)	NC score	0.018899 (rank : 100)
Query Neighborhood Hits	157	Target Neighborhood Hits	1558	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

KCND3_HUMAN
θ value	0.0113563 (rank : 45)	NC score	0.177769 (rank : 44)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.0113563 (rank : 46)	NC score	0.177835 (rank : 43)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
θ value	0.0113563 (rank : 47)	NC score	0.175777 (rank : 45)
Query Neighborhood Hits	157	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

PK2L1_HUMAN
θ value	0.0113563 (rank : 48)	NC score	0.285318 (rank : 32)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

RBP24_HUMAN
θ value	0.0113563 (rank : 49)	NC score	0.018975 (rank : 99)
Query Neighborhood Hits	157	Target Neighborhood Hits	1559	Shared Neighborhood Hits	40
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

KCNC1_HUMAN
θ value	0.0330416 (rank : 50)	NC score	0.144416 (rank : 50)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	51
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

GOGB1_HUMAN
θ value	0.0431538 (rank : 51)	NC score	0.012937 (rank : 119)
Query Neighborhood Hits	157	Target Neighborhood Hits	2297	Shared Neighborhood Hits	45
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

KCNC1_MOUSE
θ value	0.0431538 (rank : 52)	NC score	0.142097 (rank : 51)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	51
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCND1_MOUSE
θ value	0.0431538 (rank : 53)	NC score	0.151678 (rank : 48)
Query Neighborhood Hits	157	Target Neighborhood Hits	165	Shared Neighborhood Hits	54
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
θ value	0.0563607 (rank : 54)	NC score	0.149867 (rank : 49)
Query Neighborhood Hits	157	Target Neighborhood Hits	160	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNQ4_HUMAN
θ value	0.0961366 (rank : 55)	NC score	0.080975 (rank : 65)
Query Neighborhood Hits	157	Target Neighborhood Hits	136	Shared Neighborhood Hits	37
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

TRPV3_HUMAN
θ value	0.0961366 (rank : 56)	NC score	0.094871 (rank : 60)
Query Neighborhood Hits	157	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

GCC2_MOUSE
θ value	0.125558 (rank : 57)	NC score	0.017762 (rank : 104)
Query Neighborhood Hits	157	Target Neighborhood Hits	1619	Shared Neighborhood Hits	46
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

RB6I2_HUMAN
θ value	0.125558 (rank : 58)	NC score	0.012538 (rank : 123)
Query Neighborhood Hits	157	Target Neighborhood Hits	1584	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

TRPC1_HUMAN
θ value	0.125558 (rank : 59)	NC score	0.067434 (rank : 77)
Query Neighborhood Hits	157	Target Neighborhood Hits	91	Shared Neighborhood Hits	22
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	0.125558 (rank : 60)	NC score	0.067327 (rank : 78)
Query Neighborhood Hits	157	Target Neighborhood Hits	87	Shared Neighborhood Hits	20
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

MYPT1_MOUSE
θ value	0.163984 (rank : 61)	NC score	0.008853 (rank : 142)
Query Neighborhood Hits	157	Target Neighborhood Hits	539	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

TTC16_HUMAN
θ value	0.163984 (rank : 62)	NC score	0.023443 (rank : 95)
Query Neighborhood Hits	157	Target Neighborhood Hits	417	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

MYPT1_HUMAN
θ value	0.21417 (rank : 63)	NC score	0.008915 (rank : 141)
Query Neighborhood Hits	157	Target Neighborhood Hits	723	Shared Neighborhood Hits	28
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

NEB1_HUMAN
θ value	0.21417 (rank : 64)	NC score	0.017175 (rank : 105)
Query Neighborhood Hits	157	Target Neighborhood Hits	829	Shared Neighborhood Hits	37
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

PKD2_MOUSE
θ value	0.21417 (rank : 65)	NC score	0.267666 (rank : 34)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	45
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

CCHCR_MOUSE
θ value	0.365318 (rank : 66)	NC score	0.018568 (rank : 102)
Query Neighborhood Hits	157	Target Neighborhood Hits	932	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

TPTE2_HUMAN
θ value	0.365318 (rank : 67)	NC score	0.138354 (rank : 53)
Query Neighborhood Hits	157	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

CABP5_HUMAN
θ value	0.47712 (rank : 68)	NC score	0.041928 (rank : 90)
Query Neighborhood Hits	157	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

CABP5_MOUSE
θ value	0.47712 (rank : 69)	NC score	0.057490 (rank : 88)
Query Neighborhood Hits	157	Target Neighborhood Hits	207	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

CASP_HUMAN
θ value	0.47712 (rank : 70)	NC score	0.016179 (rank : 107)
Query Neighborhood Hits	157	Target Neighborhood Hits	1131	Shared Neighborhood Hits	35
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_HUMAN
θ value	0.47712 (rank : 71)	NC score	0.014732 (rank : 115)
Query Neighborhood Hits	157	Target Neighborhood Hits	1574	Shared Neighborhood Hits	39
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

KCNC3_HUMAN
θ value	0.47712 (rank : 72)	NC score	0.118190 (rank : 57)
Query Neighborhood Hits	157	Target Neighborhood Hits	256	Shared Neighborhood Hits	51
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

PKDRE_MOUSE
θ value	0.47712 (rank : 73)	NC score	0.093349 (rank : 62)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

CASP_MOUSE
θ value	0.62314 (rank : 74)	NC score	0.015417 (rank : 112)
Query Neighborhood Hits	157	Target Neighborhood Hits	1152	Shared Neighborhood Hits	38
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

KCNC3_MOUSE
θ value	0.62314 (rank : 75)	NC score	0.116003 (rank : 59)
Query Neighborhood Hits	157	Target Neighborhood Hits	173	Shared Neighborhood Hits	50
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNS1_HUMAN
θ value	0.62314 (rank : 76)	NC score	0.139996 (rank : 52)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	54
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

SMC2_MOUSE
θ value	0.62314 (rank : 77)	NC score	0.019880 (rank : 97)
Query Neighborhood Hits	157	Target Neighborhood Hits	1131	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

CUTL1_MOUSE
θ value	0.813845 (rank : 78)	NC score	0.015547 (rank : 111)
Query Neighborhood Hits	157	Target Neighborhood Hits	1620	Shared Neighborhood Hits	43
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

IGBP1_MOUSE
θ value	0.813845 (rank : 79)	NC score	0.014312 (rank : 116)
Query Neighborhood Hits	157	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q61249	Gene names	Igbp1, Pc52
Domain Architecture
Description	Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (Alpha4 phosphoprotein) (Lymphocyte signal transduction molecule alpha 4) (p52).

TBX3_HUMAN
θ value	0.813845 (rank : 80)	NC score	0.004901 (rank : 154)
Query Neighborhood Hits	157	Target Neighborhood Hits	121	Shared Neighborhood Hits	2
SwissProt Accessions	O15119, Q8TB20, Q9UKF8	Gene names	TBX3
Domain Architecture
Description	T-box transcription factor TBX3 (T-box protein 3).

TCRG1_HUMAN
θ value	0.813845 (rank : 81)	NC score	0.018132 (rank : 103)
Query Neighborhood Hits	157	Target Neighborhood Hits	929	Shared Neighborhood Hits	38
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	0.813845 (rank : 82)	NC score	0.016797 (rank : 106)
Query Neighborhood Hits	157	Target Neighborhood Hits	947	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

ANK3_HUMAN
θ value	1.06291 (rank : 83)	NC score	0.004079 (rank : 157)
Query Neighborhood Hits	157	Target Neighborhood Hits	853	Shared Neighborhood Hits	34
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANPRB_HUMAN
θ value	1.06291 (rank : 84)	NC score	0.002796 (rank : 162)
Query Neighborhood Hits	157	Target Neighborhood Hits	646	Shared Neighborhood Hits	5
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRB_MOUSE
θ value	1.06291 (rank : 85)	NC score	0.003307 (rank : 158)
Query Neighborhood Hits	157	Target Neighborhood Hits	607	Shared Neighborhood Hits	5
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

DYNA_HUMAN
θ value	1.06291 (rank : 86)	NC score	0.015226 (rank : 113)
Query Neighborhood Hits	157	Target Neighborhood Hits	1194	Shared Neighborhood Hits	40
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	1.06291 (rank : 87)	NC score	0.015987 (rank : 108)
Query Neighborhood Hits	157	Target Neighborhood Hits	1084	Shared Neighborhood Hits	41
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

OPTN_MOUSE
θ value	1.06291 (rank : 88)	NC score	0.011044 (rank : 131)
Query Neighborhood Hits	157	Target Neighborhood Hits	1120	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

TRPV1_HUMAN
θ value	1.06291 (rank : 89)	NC score	0.041473 (rank : 91)
Query Neighborhood Hits	157	Target Neighborhood Hits	184	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

CASC5_MOUSE
θ value	1.38821 (rank : 90)	NC score	0.012644 (rank : 121)
Query Neighborhood Hits	157	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

CPSF1_HUMAN
θ value	1.38821 (rank : 91)	NC score	0.010774 (rank : 134)
Query Neighborhood Hits	157	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q10570, Q96AF0	Gene names	CPSF1, CPSF160
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 160 kDa subunit (CPSF 160 kDa subunit).

FLIP1_HUMAN
θ value	1.38821 (rank : 92)	NC score	0.011152 (rank : 129)
Query Neighborhood Hits	157	Target Neighborhood Hits	1405	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

KCNC4_HUMAN
θ value	1.38821 (rank : 93)	NC score	0.125661 (rank : 54)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	52
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
θ value	1.38821 (rank : 94)	NC score	0.118765 (rank : 56)
Query Neighborhood Hits	157	Target Neighborhood Hits	130	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

SON_MOUSE
θ value	1.81305 (rank : 95)	NC score	0.011651 (rank : 127)
Query Neighborhood Hits	157	Target Neighborhood Hits	957	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

TANK_MOUSE
θ value	1.81305 (rank : 96)	NC score	0.012735 (rank : 120)
Query Neighborhood Hits	157	Target Neighborhood Hits	80	Shared Neighborhood Hits	6
SwissProt Accessions	P70347, Q61178	Gene names	Tank, Itraf
Domain Architecture
Description	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF).

TRIPB_HUMAN
θ value	1.81305 (rank : 97)	NC score	0.011911 (rank : 125)
Query Neighborhood Hits	157	Target Neighborhood Hits	1587	Shared Neighborhood Hits	41
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

TRPV4_HUMAN
θ value	1.81305 (rank : 98)	NC score	0.061296 (rank : 85)
Query Neighborhood Hits	157	Target Neighborhood Hits	150	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	1.81305 (rank : 99)	NC score	0.062808 (rank : 84)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

ANPRA_HUMAN
θ value	2.36792 (rank : 100)	NC score	0.002513 (rank : 164)
Query Neighborhood Hits	157	Target Neighborhood Hits	612	Shared Neighborhood Hits	5
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	2.36792 (rank : 101)	NC score	0.002516 (rank : 163)
Query Neighborhood Hits	157	Target Neighborhood Hits	600	Shared Neighborhood Hits	5
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

CCD93_HUMAN
θ value	2.36792 (rank : 102)	NC score	0.013825 (rank : 118)
Query Neighborhood Hits	157	Target Neighborhood Hits	600	Shared Neighborhood Hits	33
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

HRH1_HUMAN
θ value	2.36792 (rank : 103)	NC score	-0.001023 (rank : 169)
Query Neighborhood Hits	157	Target Neighborhood Hits	916	Shared Neighborhood Hits	7
SwissProt Accessions	P35367	Gene names	HRH1
Domain Architecture
Description	Histamine H1 receptor.

NKTR_HUMAN
θ value	2.36792 (rank : 104)	NC score	0.006332 (rank : 149)
Query Neighborhood Hits	157	Target Neighborhood Hits	658	Shared Neighborhood Hits	28
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

SON_HUMAN
θ value	2.36792 (rank : 105)	NC score	0.003182 (rank : 160)
Query Neighborhood Hits	157	Target Neighborhood Hits	1568	Shared Neighborhood Hits	21
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

TRPV3_MOUSE
θ value	2.36792 (rank : 106)	NC score	0.066529 (rank : 80)
Query Neighborhood Hits	157	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

CMTA1_HUMAN
θ value	3.0926 (rank : 107)	NC score	0.012551 (rank : 122)
Query Neighborhood Hits	157	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

PKDRE_HUMAN
θ value	3.0926 (rank : 108)	NC score	0.118177 (rank : 58)
Query Neighborhood Hits	157	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PSN2_MOUSE
θ value	3.0926 (rank : 109)	NC score	0.033432 (rank : 92)
Query Neighborhood Hits	157	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

TRAIP_HUMAN
θ value	3.0926 (rank : 110)	NC score	0.012133 (rank : 124)
Query Neighborhood Hits	157	Target Neighborhood Hits	780	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

ZRAB2_HUMAN
θ value	3.0926 (rank : 111)	NC score	0.015554 (rank : 110)
Query Neighborhood Hits	157	Target Neighborhood Hits	120	Shared Neighborhood Hits	10
SwissProt Accessions	O95218, Q9UP63	Gene names	ZRANB2, ZIS, ZNF265
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 2 Zinc finger protein 265 (Zinc finger, splicing).

AT5F1_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.009683 (rank : 138)
Query Neighborhood Hits	157	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P24539, Q9BQ68, Q9BRU8	Gene names	ATP5F1
Domain Architecture
Description	ATP synthase B chain, mitochondrial precursor (EC 3.6.3.14).

BICD2_MOUSE
θ value	4.03905 (rank : 113)	NC score	0.011895 (rank : 126)
Query Neighborhood Hits	157	Target Neighborhood Hits	864	Shared Neighborhood Hits	35
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

DMP1_MOUSE
θ value	4.03905 (rank : 114)	NC score	0.007443 (rank : 144)
Query Neighborhood Hits	157	Target Neighborhood Hits	498	Shared Neighborhood Hits	18
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

IWS1_MOUSE
θ value	4.03905 (rank : 115)	NC score	0.026822 (rank : 94)
Query Neighborhood Hits	157	Target Neighborhood Hits	1258	Shared Neighborhood Hits	31
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PIBF1_HUMAN
θ value	4.03905 (rank : 116)	NC score	0.011049 (rank : 130)
Query Neighborhood Hits	157	Target Neighborhood Hits	1041	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

TPTE_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.094434 (rank : 61)
Query Neighborhood Hits	157	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

ABRA_MOUSE
θ value	5.27518 (rank : 118)	NC score	0.007625 (rank : 143)
Query Neighborhood Hits	157	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BUZ1, Q3UU01, Q8BLH3, Q8K431	Gene names	Abra
Domain Architecture	No domain graphic available
Description	Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS).

ANR26_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.010768 (rank : 135)
Query Neighborhood Hits	157	Target Neighborhood Hits	1614	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ATF6B_MOUSE
θ value	5.27518 (rank : 120)	NC score	0.005741 (rank : 152)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	4
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

BICD2_HUMAN
θ value	5.27518 (rank : 121)	NC score	0.010914 (rank : 132)
Query Neighborhood Hits	157	Target Neighborhood Hits	856	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

KCNG1_HUMAN
θ value	5.27518 (rank : 122)	NC score	0.072378 (rank : 72)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNG3_MOUSE
θ value	5.27518 (rank : 123)	NC score	0.092981 (rank : 63)
Query Neighborhood Hits	157	Target Neighborhood Hits	91	Shared Neighborhood Hits	42
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNS1_MOUSE
θ value	5.27518 (rank : 124)	NC score	0.121820 (rank : 55)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	48
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

LGR4_HUMAN
θ value	5.27518 (rank : 125)	NC score	-0.001168 (rank : 170)
Query Neighborhood Hits	157	Target Neighborhood Hits	481	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

MEPE_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.028849 (rank : 93)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NQ76	Gene names	MEPE
Domain Architecture
Description	Matrix extracellular phosphoglycoprotein precursor (Osteoblast/osteocyte factor 45) (OF45).

NUMA1_HUMAN
θ value	5.27518 (rank : 127)	NC score	0.010687 (rank : 136)
Query Neighborhood Hits	157	Target Neighborhood Hits	1523	Shared Neighborhood Hits	43
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

OX2R_HUMAN
θ value	5.27518 (rank : 128)	NC score	-0.002590 (rank : 172)
Query Neighborhood Hits	157	Target Neighborhood Hits	929	Shared Neighborhood Hits	8
SwissProt Accessions	O43614	Gene names	HCRTR2
Domain Architecture
Description	Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2).

OX2R_MOUSE
θ value	5.27518 (rank : 129)	NC score	-0.002616 (rank : 173)
Query Neighborhood Hits	157	Target Neighborhood Hits	921	Shared Neighborhood Hits	7
SwissProt Accessions	P58308, Q5SGC8, Q6VLX3, Q8BG12	Gene names	Hcrtr2, Mox2r
Domain Architecture
Description	Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2).

RIMB1_HUMAN
θ value	5.27518 (rank : 130)	NC score	0.009421 (rank : 139)
Query Neighborhood Hits	157	Target Neighborhood Hits	1479	Shared Neighborhood Hits	38
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TRAK1_HUMAN
θ value	5.27518 (rank : 131)	NC score	0.010895 (rank : 133)
Query Neighborhood Hits	157	Target Neighborhood Hits	660	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

AF9_HUMAN
θ value	6.88961 (rank : 132)	NC score	0.006853 (rank : 145)
Query Neighborhood Hits	157	Target Neighborhood Hits	202	Shared Neighborhood Hits	11
SwissProt Accessions	P42568	Gene names	MLLT3, AF9, YEATS3
Domain Architecture
Description	Protein AF-9 (ALL1 fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3).

AT1A2_MOUSE
θ value	6.88961 (rank : 133)	NC score	0.000521 (rank : 168)
Query Neighborhood Hits	157	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PIE5	Gene names	Atp1a2
Domain Architecture	No domain graphic available
Description	Sodium/potassium-transporting ATPase alpha-2 chain precursor (EC 3.6.3.9) (Sodium pump 2) (Na+/K+ ATPase 2) (Alpha(+)).

CR034_MOUSE
θ value	6.88961 (rank : 134)	NC score	0.014099 (rank : 117)
Query Neighborhood Hits	157	Target Neighborhood Hits	643	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

DIP2A_MOUSE
θ value	6.88961 (rank : 135)	NC score	0.004228 (rank : 156)
Query Neighborhood Hits	157	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BWT5, Q8CHI0	Gene names	Dip2a, Dip2, Kiaa0184
Domain Architecture
Description	Disco-interacting protein 2 homolog A.

FLIP1_MOUSE
θ value	6.88961 (rank : 136)	NC score	0.011253 (rank : 128)
Query Neighborhood Hits	157	Target Neighborhood Hits	1176	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

LAD1_HUMAN
θ value	6.88961 (rank : 137)	NC score	0.004270 (rank : 155)
Query Neighborhood Hits	157	Target Neighborhood Hits	441	Shared Neighborhood Hits	12
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

LYST_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.002366 (rank : 165)
Query Neighborhood Hits	157	Target Neighborhood Hits	324	Shared Neighborhood Hits	7
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

MARH4_HUMAN
θ value	6.88961 (rank : 139)	NC score	0.005919 (rank : 150)
Query Neighborhood Hits	157	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2E8, Q86WR8	Gene names	MARCH4, KIAA1399, RNF174
Domain Architecture	No domain graphic available
Description	Membrane-associated RING finger protein 4 (Membrane-associated RING-CH protein IV) (MARCH-IV) (RING finger protein 174).

NGAP_HUMAN
θ value	6.88961 (rank : 140)	NC score	0.006461 (rank : 147)
Query Neighborhood Hits	157	Target Neighborhood Hits	517	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

PI2R_HUMAN
θ value	6.88961 (rank : 141)	NC score	0.003070 (rank : 161)
Query Neighborhood Hits	157	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	P43119	Gene names	PTGIR, PRIPR
Domain Architecture
Description	Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) (Prostaglandin I2 receptor).

PSD4_HUMAN
θ value	6.88961 (rank : 142)	NC score	0.005063 (rank : 153)
Query Neighborhood Hits	157	Target Neighborhood Hits	178	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

TGON2_HUMAN
θ value	6.88961 (rank : 143)	NC score	0.015713 (rank : 109)
Query Neighborhood Hits	157	Target Neighborhood Hits	1037	Shared Neighborhood Hits	27
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CALB2_HUMAN
θ value	8.99809 (rank : 144)	NC score	0.019843 (rank : 98)
Query Neighborhood Hits	157	Target Neighborhood Hits	149	Shared Neighborhood Hits	14
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

CALB2_MOUSE
θ value	8.99809 (rank : 145)	NC score	0.020224 (rank : 96)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	15
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

CENPE_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.006453 (rank : 148)
Query Neighborhood Hits	157	Target Neighborhood Hits	2060	Shared Neighborhood Hits	44
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CY15A_HUMAN
θ value	8.99809 (rank : 147)	NC score	0.006645 (rank : 146)
Query Neighborhood Hits	157	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZA5	Gene names	CYorf15A
Domain Architecture	No domain graphic available
Description	Putative testis protein CYorf15A.

CYLN2_MOUSE
θ value	8.99809 (rank : 148)	NC score	0.009286 (rank : 140)
Query Neighborhood Hits	157	Target Neighborhood Hits	1002	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

GASP2_MOUSE
θ value	8.99809 (rank : 149)	NC score	0.003231 (rank : 159)
Query Neighborhood Hits	157	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUY8	Gene names	Gprasp2
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 2 (GASP-2).

K0831_HUMAN
θ value	8.99809 (rank : 150)	NC score	0.005916 (rank : 151)
Query Neighborhood Hits	157	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q6ZNE5, O94920	Gene names	KIAA0831
Domain Architecture	No domain graphic available
Description	Protein KIAA0831.

KIF1B_MOUSE
θ value	8.99809 (rank : 151)	NC score	0.000653 (rank : 167)
Query Neighborhood Hits	157	Target Neighborhood Hits	167	Shared Neighborhood Hits	10
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

KLF5_HUMAN
θ value	8.99809 (rank : 152)	NC score	-0.005019 (rank : 174)
Query Neighborhood Hits	157	Target Neighborhood Hits	727	Shared Neighborhood Hits	3
SwissProt Accessions	Q13887, Q9UHP8	Gene names	KLF5, BTEB2, CKLF, IKLF
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 5 (Intestinal-enriched krueppel-like factor) (Colon krueppel-like factor) (Transcription factor BTEB2) (Basic transcription element-binding protein 2) (BTE-binding protein 2) (GC box-binding protein 2).

MPP4_HUMAN
θ value	8.99809 (rank : 153)	NC score	0.000872 (rank : 166)
Query Neighborhood Hits	157	Target Neighborhood Hits	205	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

MY18A_HUMAN
θ value	8.99809 (rank : 154)	NC score	0.009905 (rank : 137)
Query Neighborhood Hits	157	Target Neighborhood Hits	1929	Shared Neighborhood Hits	51
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

OLF9_MOUSE
θ value	8.99809 (rank : 155)	NC score	-0.001771 (rank : 171)
Query Neighborhood Hits	157	Target Neighborhood Hits	700	Shared Neighborhood Hits	13
SwissProt Accessions	Q60885, Q8VGC0	Gene names	Olfr9, Mor269-3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 9 (Olfactory receptor 269-3) (Odorant receptor M25).

SEGN_HUMAN
θ value	8.99809 (rank : 156)	NC score	0.014780 (rank : 114)
Query Neighborhood Hits	157	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	O76038, Q5VV44, Q96QV7, Q9UJF6	Gene names	SCGN, SECRET
Domain Architecture
Description	Secretagogin.

ZN184_HUMAN
θ value	8.99809 (rank : 157)	NC score	-0.005540 (rank : 175)
Query Neighborhood Hits	157	Target Neighborhood Hits	811	Shared Neighborhood Hits	4
SwissProt Accessions	Q99676, O60792, Q8TBA9	Gene names	ZNF184
Domain Architecture
Description	Zinc finger protein 184.

KCNA1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.079598 (rank : 67)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA1_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.080950 (rank : 66)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	39
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA2_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.077560 (rank : 69)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA2_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.078390 (rank : 68)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA3_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.070679 (rank : 75)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.069827 (rank : 76)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	32
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA4_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.057425 (rank : 89)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	27
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.057840 (rank : 87)
Query Neighborhood Hits	157	Target Neighborhood Hits	98	Shared Neighborhood Hits	27
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA5_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.067158 (rank : 79)
Query Neighborhood Hits	157	Target Neighborhood Hits	124	Shared Neighborhood Hits	34
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.072057 (rank : 73)
Query Neighborhood Hits	157	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA6_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.072865 (rank : 71)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	35
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA6_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.075654 (rank : 70)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	39
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG2_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.065761 (rank : 81)
Query Neighborhood Hits	157	Target Neighborhood Hits	83	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG3_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.092539 (rank : 64)
Query Neighborhood Hits	157	Target Neighborhood Hits	91	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG4_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.064120 (rank : 82)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.063414 (rank : 83)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	32
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ1_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.071643 (rank : 74)
Query Neighborhood Hits	157	Target Neighborhood Hits	175	Shared Neighborhood Hits	36
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ5_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.058019 (rank : 86)
Query Neighborhood Hits	157	Target Neighborhood Hits	163	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

Hits sorted by NC score

SCN9A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 13)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	157
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN3A_HUMAN
NC score	0.995789 (rank : 2)	θ value	0 (rank : 7)
Query Neighborhood Hits	157	Target Neighborhood Hits	115	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN2A_HUMAN
NC score	0.995157 (rank : 3)	θ value	0 (rank : 6)
Query Neighborhood Hits	157	Target Neighborhood Hits	157	Shared Neighborhood Hits	79
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN1A_HUMAN
NC score	0.994925 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	79
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN8A_MOUSE
NC score	0.994332 (rank : 5)	θ value	0 (rank : 12)
Query Neighborhood Hits	157	Target Neighborhood Hits	136	Shared Neighborhood Hits	76
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_HUMAN
NC score	0.993884 (rank : 6)	θ value	0 (rank : 11)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SC10A_MOUSE
NC score	0.991771 (rank : 7)	θ value	0 (rank : 2)
Query Neighborhood Hits	157	Target Neighborhood Hits	107	Shared Neighborhood Hits	69
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC10A_HUMAN
NC score	0.991707 (rank : 8)	θ value	0 (rank : 1)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN4A_HUMAN
NC score	0.990950 (rank : 9)	θ value	0 (rank : 8)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	74
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
NC score	0.985736 (rank : 10)	θ value	0 (rank : 9)
Query Neighborhood Hits	157	Target Neighborhood Hits	145	Shared Neighborhood Hits	76
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN7A_HUMAN
NC score	0.985220 (rank : 11)	θ value	0 (rank : 10)
Query Neighborhood Hits	157	Target Neighborhood Hits	135	Shared Neighborhood Hits	59
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SC11A_MOUSE
NC score	0.984696 (rank : 12)	θ value	0 (rank : 4)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	72
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC11A_HUMAN
NC score	0.982985 (rank : 13)	θ value	0 (rank : 3)
Query Neighborhood Hits	157	Target Neighborhood Hits	111	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

CAC1I_HUMAN
NC score	0.893607 (rank : 14)	θ value	1.31376e-75 (rank : 14)
Query Neighborhood Hits	157	Target Neighborhood Hits	138	Shared Neighborhood Hits	63
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.872989 (rank : 15)	θ value	6.7473e-72 (rank : 18)
Query Neighborhood Hits	157	Target Neighborhood Hits	230	Shared Neighborhood Hits	63
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.866034 (rank : 16)	θ value	1.66191e-70 (rank : 21)
Query Neighborhood Hits	157	Target Neighborhood Hits	307	Shared Neighborhood Hits	63
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1E_MOUSE
NC score	0.856030 (rank : 17)	θ value	4.83544e-70 (rank : 24)
Query Neighborhood Hits	157	Target Neighborhood Hits	167	Shared Neighborhood Hits	63
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.855635 (rank : 18)	θ value	2.83479e-70 (rank : 22)
Query Neighborhood Hits	157	Target Neighborhood Hits	148	Shared Neighborhood Hits	64
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1A_MOUSE
NC score	0.851713 (rank : 19)	θ value	1.60597e-73 (rank : 15)
Query Neighborhood Hits	157	Target Neighborhood Hits	267	Shared Neighborhood Hits	61
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1G_HUMAN
NC score	0.848899 (rank : 20)	θ value	1.00825e-67 (rank : 28)
Query Neighborhood Hits	157	Target Neighborhood Hits	587	Shared Neighborhood Hits	61
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1S_MOUSE
NC score	0.846393 (rank : 21)	θ value	8.81223e-72 (rank : 19)
Query Neighborhood Hits	157	Target Neighborhood Hits	98	Shared Neighborhood Hits	59
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
NC score	0.845888 (rank : 22)	θ value	1.35953e-72 (rank : 16)
Query Neighborhood Hits	157	Target Neighborhood Hits	118	Shared Neighborhood Hits	61
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1S_HUMAN
NC score	0.845106 (rank : 23)	θ value	3.13423e-69 (rank : 26)
Query Neighborhood Hits	157	Target Neighborhood Hits	92	Shared Neighborhood Hits	56
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_HUMAN
NC score	0.845017 (rank : 24)	θ value	3.83135e-67 (rank : 29)
Query Neighborhood Hits	157	Target Neighborhood Hits	257	Shared Neighborhood Hits	57
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_HUMAN
NC score	0.843979 (rank : 25)	θ value	5.1662e-72 (rank : 17)
Query Neighborhood Hits	157	Target Neighborhood Hits	387	Shared Neighborhood Hits	62
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
NC score	0.842207 (rank : 26)	θ value	1.96316e-71 (rank : 20)
Query Neighborhood Hits	157	Target Neighborhood Hits	351	Shared Neighborhood Hits	59
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_MOUSE
NC score	0.841119 (rank : 27)	θ value	3.70236e-70 (rank : 23)
Query Neighborhood Hits	157	Target Neighborhood Hits	142	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.840279 (rank : 28)	θ value	4.83544e-70 (rank : 25)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	61
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.838679 (rank : 29)	θ value	3.4653e-68 (rank : 27)
Query Neighborhood Hits	157	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.833834 (rank : 30)	θ value	1.04338e-64 (rank : 30)
Query Neighborhood Hits	157	Target Neighborhood Hits	158	Shared Neighborhood Hits	60
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PK2L2_HUMAN
NC score	0.309094 (rank : 31)	θ value	0.000158464 (rank : 34)
Query Neighborhood Hits	157	Target Neighborhood Hits	90	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.285318 (rank : 32)	θ value	0.0113563 (rank : 48)
Query Neighborhood Hits	157	Target Neighborhood Hits	132	Shared Neighborhood Hits	45
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.274068 (rank : 33)	θ value	0.000602161 (rank : 35)
Query Neighborhood Hits	157	Target Neighborhood Hits	84	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_MOUSE
NC score	0.267666 (rank : 34)	θ value	0.21417 (rank : 65)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	45
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
NC score	0.264411 (rank : 35)	θ value	0.00869519 (rank : 43)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	43
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNF1_HUMAN
NC score	0.231756 (rank : 36)	θ value	0.00175202 (rank : 36)
Query Neighborhood Hits	157	Target Neighborhood Hits	109	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNB2_HUMAN
NC score	0.216165 (rank : 37)	θ value	9.29e-05 (rank : 31)
Query Neighborhood Hits	157	Target Neighborhood Hits	212	Shared Neighborhood Hits	57
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNV2_HUMAN
NC score	0.215412 (rank : 38)	θ value	0.00298849 (rank : 39)
Query Neighborhood Hits	157	Target Neighborhood Hits	137	Shared Neighborhood Hits	54
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNS2_MOUSE
NC score	0.207499 (rank : 39)	θ value	0.00175202 (rank : 37)
Query Neighborhood Hits	157	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
NC score	0.202245 (rank : 40)	θ value	0.00298849 (rank : 38)
Query Neighborhood Hits	157	Target Neighborhood Hits	129	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_MOUSE
NC score	0.196544 (rank : 41)	θ value	0.000158464 (rank : 33)
Query Neighborhood Hits	157	Target Neighborhood Hits	154	Shared Neighborhood Hits	56
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNB1_HUMAN
NC score	0.196508 (rank : 42)	θ value	0.000158464 (rank : 32)
Query Neighborhood Hits	157	Target Neighborhood Hits	169	Shared Neighborhood Hits	56
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCND3_MOUSE
NC score	0.177835 (rank : 43)	θ value	0.0113563 (rank : 46)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.177769 (rank : 44)	θ value	0.0113563 (rank : 45)
Query Neighborhood Hits	157	Target Neighborhood Hits	162	Shared Neighborhood Hits	56
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
NC score	0.175777 (rank : 45)	θ value	0.0113563 (rank : 47)
Query Neighborhood Hits	157	Target Neighborhood Hits	125	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND2_MOUSE
NC score	0.170500 (rank : 46)	θ value	0.00509761 (rank : 41)
Query Neighborhood Hits	157	Target Neighborhood Hits	156	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.170337 (rank : 47)	θ value	0.00509761 (rank : 40)
Query Neighborhood Hits	157	Target Neighborhood Hits	154	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.151678 (rank : 48)	θ value	0.0431538 (rank : 53)
Query Neighborhood Hits	157	Target Neighborhood Hits	165	Shared Neighborhood Hits	54
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.149867 (rank : 49)	θ value	0.0563607 (rank : 54)
Query Neighborhood Hits	157	Target Neighborhood Hits	160	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNC1_HUMAN
NC score	0.144416 (rank : 50)	θ value	0.0330416 (rank : 50)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	51
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
NC score	0.142097 (rank : 51)	θ value	0.0431538 (rank : 52)
Query Neighborhood Hits	157	Target Neighborhood Hits	133	Shared Neighborhood Hits	51
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNS1_HUMAN
NC score	0.139996 (rank : 52)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	157	Target Neighborhood Hits	116	Shared Neighborhood Hits	54
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

TPTE2_HUMAN
NC score	0.138354 (rank : 53)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	157	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNC4_HUMAN
NC score	0.125661 (rank : 54)	θ value	1.38821 (rank : 93)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	52
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNS1_MOUSE
NC score	0.121820 (rank : 55)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	157	Target Neighborhood Hits	114	Shared Neighborhood Hits	48
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC4_MOUSE
NC score	0.118765 (rank : 56)	θ value	1.38821 (rank : 94)
Query Neighborhood Hits	157	Target Neighborhood Hits	130	Shared Neighborhood Hits	49
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNC3_HUMAN
NC score	0.118190 (rank : 57)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	157	Target Neighborhood Hits	256	Shared Neighborhood Hits	51
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

PKDRE_HUMAN
NC score	0.118177 (rank : 58)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	157	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNC3_MOUSE
NC score	0.116003 (rank : 59)	θ value	0.62314 (rank : 75)
Query Neighborhood Hits	157	Target Neighborhood Hits	173	Shared Neighborhood Hits	50
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

TRPV3_HUMAN
NC score	0.094871 (rank : 60)	θ value	0.0961366 (rank : 56)
Query Neighborhood Hits	157	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TPTE_HUMAN
NC score	0.094434 (rank : 61)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	157	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

PKDRE_MOUSE
NC score	0.093349 (rank : 62)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	157	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNG3_MOUSE
NC score	0.092981 (rank : 63)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	157	Target Neighborhood Hits	91	Shared Neighborhood Hits	42
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_HUMAN
NC score	0.092539 (rank : 64)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	157	Target Neighborhood Hits	91	Shared Neighborhood Hits	41
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNQ4_HUMAN
NC score	0.080975 (rank : 65)	θ value	0.0961366 (rank : 55)
Query Neighborhood Hits	157	Target Neighborhood Hits	136	Shared Neighborhood Hits	37
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNA1_MOUSE
NC score	0.080950 (rank : 66)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	39
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA1_HUMAN
NC score	0.079598 (rank : 67)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	157	Target Neighborhood Hits	104	Shared Neighborhood Hits	38
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA2_MOUSE
NC score	0.078390 (rank : 68)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	157	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA2_HUMAN
NC score	0.077560 (rank : 69)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA6_MOUSE
NC score	0.075654 (rank : 70)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	157	Target Neighborhood Hits	106	Shared Neighborhood Hits	39
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNA6_HUMAN
NC score	0.072865 (rank : 71)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	157	Target Neighborhood Hits	100	Shared Neighborhood Hits	35
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNG1_HUMAN
NC score	0.072378 (rank : 72)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNA5_MOUSE
NC score	0.072057 (rank : 73)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	157	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNQ1_MOUSE
NC score	0.071643 (rank : 74)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	157	Target Neighborhood Hits	175	Shared Neighborhood Hits	36
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA3_HUMAN
NC score	0.070679 (rank : 75)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	157	Target Neighborhood Hits	101	Shared Neighborhood Hits	34
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
NC score	0.069827 (rank : 76)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	157	Target Neighborhood Hits	103	Shared Neighborhood Hits	32
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

TRPC1_HUMAN
NC score	0.067434 (rank : 77)	θ value	0.125558 (rank : 59)
Query Neighborhood Hits	157	Target Neighborhood Hits	91	Shared Neighborhood Hits	22
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
NC score	0.067327 (rank : 78)	θ value	0.125558 (rank : 60)
Query Neighborhood Hits	157	Target Neighborhood Hits	87	Shared Neighborhood Hits	20
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

KCNA5_HUMAN
NC score	0.067158 (rank : 79)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	157	Target Neighborhood Hits	124	Shared Neighborhood Hits	34
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

TRPV3_MOUSE
NC score	0.066529 (rank : 80)	θ value	2.36792 (rank : 106)
Query Neighborhood Hits	157	Target Neighborhood Hits	188	Shared Neighborhood Hits	28
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

KCNG2_HUMAN
NC score	0.065761 (rank : 81)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	157	Target Neighborhood Hits	83	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG4_HUMAN
NC score	0.064120 (rank : 82)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	27
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
NC score	0.063414 (rank : 83)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	157	Target Neighborhood Hits	99	Shared Neighborhood Hits	32
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

TRPV4_MOUSE
NC score	0.062808 (rank : 84)	θ value	1.81305 (rank : 99)
Query Neighborhood Hits	157	Target Neighborhood Hits	117	Shared Neighborhood Hits	26
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_HUMAN
NC score	0.061296 (rank : 85)	θ value	1.81305 (rank : 98)
Query Neighborhood Hits	157	Target Neighborhood Hits	150	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

KCNQ5_HUMAN
NC score	0.058019 (rank : 86)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	157	Target Neighborhood Hits	163	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

KCNA4_MOUSE
NC score	0.057840 (rank : 87)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	157	Target Neighborhood Hits	98	Shared Neighborhood Hits	27
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

CABP5_MOUSE
NC score	0.057490 (rank : 88)	θ value	0.47712 (rank : 69)
Query Neighborhood Hits	157	Target Neighborhood Hits	207	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KCNA4_HUMAN
NC score	0.057425 (rank : 89)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	157	Target Neighborhood Hits	108	Shared Neighborhood Hits	27
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

CABP5_HUMAN
NC score	0.041928 (rank : 90)	θ value	0.47712 (rank : 68)
Query Neighborhood Hits	157	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

TRPV1_HUMAN
NC score	0.041473 (rank : 91)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	157	Target Neighborhood Hits	184	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

PSN2_MOUSE
NC score	0.033432 (rank : 92)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	157	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

MEPE_HUMAN
NC score	0.028849 (rank : 93)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	157	Target Neighborhood Hits	105	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NQ76	Gene names	MEPE
Domain Architecture
Description	Matrix extracellular phosphoglycoprotein precursor (Osteoblast/osteocyte factor 45) (OF45).

IWS1_MOUSE
NC score	0.026822 (rank : 94)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	157	Target Neighborhood Hits	1258	Shared Neighborhood Hits	31
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TTC16_HUMAN
NC score	0.023443 (rank : 95)	θ value	0.163984 (rank : 62)
Query Neighborhood Hits	157	Target Neighborhood Hits	417	Shared Neighborhood Hits	20
SwissProt Accessions	Q8NEE8, Q5JU66, Q96M72	Gene names	TTC16
Domain Architecture	No domain graphic available
Description	Tetratricopeptide repeat protein 16 (TPR repeat protein 16).

CALB2_MOUSE
NC score	0.020224 (rank : 96)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	157	Target Neighborhood Hits	141	Shared Neighborhood Hits	15
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

SMC2_MOUSE
NC score	0.019880 (rank : 97)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	157	Target Neighborhood Hits	1131	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

CALB2_HUMAN
NC score	0.019843 (rank : 98)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	157	Target Neighborhood Hits	149	Shared Neighborhood Hits	14
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

RBP24_HUMAN
NC score	0.018975 (rank : 99)	θ value	0.0113563 (rank : 49)
Query Neighborhood Hits	157	Target Neighborhood Hits	1559	Shared Neighborhood Hits	40
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

GCC2_HUMAN
NC score	0.018899 (rank : 100)	θ value	0.0113563 (rank : 44)
Query Neighborhood Hits	157	Target Neighborhood Hits	1558	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

SMC2_HUMAN
NC score	0.018691 (rank : 101)	θ value	0.00509761 (rank : 42)
Query Neighborhood Hits	157	Target Neighborhood Hits	1405	Shared Neighborhood Hits	38
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

CCHCR_MOUSE
NC score	0.018568 (rank : 102)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	157	Target Neighborhood Hits	932	Shared Neighborhood Hits	39
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

TCRG1_HUMAN
NC score	0.018132 (rank : 103)	θ value	0.813845 (rank : 81)
Query Neighborhood Hits	157	Target Neighborhood Hits	929	Shared Neighborhood Hits	38
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

GCC2_MOUSE
NC score	0.017762 (rank : 104)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	157	Target Neighborhood Hits	1619	Shared Neighborhood Hits	46
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

NEB1_HUMAN
NC score	0.017175 (rank : 105)	θ value	0.21417 (rank : 64)
Query Neighborhood Hits	157	Target Neighborhood Hits	829	Shared Neighborhood Hits	37
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

TCRG1_MOUSE
NC score	0.016797 (rank : 106)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	157	Target Neighborhood Hits	947	Shared Neighborhood Hits	37
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

CASP_HUMAN
NC score	0.016179 (rank : 107)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	157	Target Neighborhood Hits	1131	Shared Neighborhood Hits	35
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

DYNA_MOUSE
NC score	0.015987 (rank : 108)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	157	Target Neighborhood Hits	1084	Shared Neighborhood Hits	41
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

TGON2_HUMAN
NC score	0.015713 (rank : 109)	θ value	6.88961 (rank : 143)
Query Neighborhood Hits	157	Target Neighborhood Hits	1037	Shared Neighborhood Hits	27
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

ZRAB2_HUMAN
NC score	0.015554 (rank : 110)	θ value	3.0926 (rank : 111)
Query Neighborhood Hits	157	Target Neighborhood Hits	120	Shared Neighborhood Hits	10
SwissProt Accessions	O95218, Q9UP63	Gene names	ZRANB2, ZIS, ZNF265
Domain Architecture
Description	Zinc finger Ran-binding domain-containing protein 2 Zinc finger protein 265 (Zinc finger, splicing).

CUTL1_MOUSE
NC score	0.015547 (rank : 111)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	157	Target Neighborhood Hits	1620	Shared Neighborhood Hits	43
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

CASP_MOUSE
NC score	0.015417 (rank : 112)	θ value	0.62314 (rank : 74)
Query Neighborhood Hits	157	Target Neighborhood Hits	1152	Shared Neighborhood Hits	38
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

DYNA_HUMAN
NC score	0.015226 (rank : 113)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	157	Target Neighborhood Hits	1194	Shared Neighborhood Hits	40
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

SEGN_HUMAN
NC score	0.014780 (rank : 114)	θ value	8.99809 (rank : 156)
Query Neighborhood Hits	157	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	O76038, Q5VV44, Q96QV7, Q9UJF6	Gene names	SCGN, SECRET
Domain Architecture
Description	Secretagogin.

CUTL1_HUMAN
NC score	0.014732 (rank : 115)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	157	Target Neighborhood Hits	1574	Shared Neighborhood Hits	39
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

IGBP1_MOUSE
NC score	0.014312 (rank : 116)	θ value	0.813845 (rank : 79)
Query Neighborhood Hits	157	Target Neighborhood Hits	34	Shared Neighborhood Hits	3
SwissProt Accessions	Q61249	Gene names	Igbp1, Pc52
Domain Architecture
Description	Immunoglobulin-binding protein 1 (CD79a-binding protein 1) (Alpha4 phosphoprotein) (Lymphocyte signal transduction molecule alpha 4) (p52).

CR034_MOUSE
NC score	0.014099 (rank : 117)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	157	Target Neighborhood Hits	643	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

CCD93_HUMAN
NC score	0.013825 (rank : 118)	θ value	2.36792 (rank : 102)
Query Neighborhood Hits	157	Target Neighborhood Hits	600	Shared Neighborhood Hits	33
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

GOGB1_HUMAN
NC score	0.012937 (rank : 119)	θ value	0.0431538 (rank : 51)
Query Neighborhood Hits	157	Target Neighborhood Hits	2297	Shared Neighborhood Hits	45
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

TANK_MOUSE
NC score	0.012735 (rank : 120)	θ value	1.81305 (rank : 96)
Query Neighborhood Hits	157	Target Neighborhood Hits	80	Shared Neighborhood Hits	6
SwissProt Accessions	P70347, Q61178	Gene names	Tank, Itraf
Domain Architecture
Description	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF).

CASC5_MOUSE
NC score	0.012644 (rank : 121)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	157	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

CMTA1_HUMAN
NC score	0.012551 (rank : 122)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	157	Target Neighborhood Hits	217	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

RB6I2_HUMAN
NC score	0.012538 (rank : 123)	θ value	0.125558 (rank : 58)
Query Neighborhood Hits	157	Target Neighborhood Hits	1584	Shared Neighborhood Hits	42
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

TRAIP_HUMAN
NC score	0.012133 (rank : 124)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	157	Target Neighborhood Hits	780	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

TRIPB_HUMAN
NC score	0.011911 (rank : 125)	θ value	1.81305 (rank : 97)
Query Neighborhood Hits	157	Target Neighborhood Hits	1587	Shared Neighborhood Hits	41
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

BICD2_MOUSE
NC score	0.011895 (rank : 126)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	157	Target Neighborhood Hits	864	Shared Neighborhood Hits	35
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

SON_MOUSE
NC score	0.011651 (rank : 127)	θ value	1.81305 (rank : 95)
Query Neighborhood Hits	157	Target Neighborhood Hits	957	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

FLIP1_MOUSE
NC score	0.011253 (rank : 128)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	157	Target Neighborhood Hits	1176	Shared Neighborhood Hits	38
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FLIP1_HUMAN
NC score	0.011152 (rank : 129)	θ value	1.38821 (rank : 92)
Query Neighborhood Hits	157	Target Neighborhood Hits	1405	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

PIBF1_HUMAN
NC score	0.011049 (rank : 130)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	157	Target Neighborhood Hits	1041	Shared Neighborhood Hits	39
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

OPTN_MOUSE
NC score	0.011044 (rank : 131)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	157	Target Neighborhood Hits	1120	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

BICD2_HUMAN
NC score	0.010914 (rank : 132)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	157	Target Neighborhood Hits	856	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

TRAK1_HUMAN
NC score	0.010895 (rank : 133)	θ value	5.27518 (rank : 131)
Query Neighborhood Hits	157	Target Neighborhood Hits	660	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

CPSF1_HUMAN
NC score	0.010774 (rank : 134)	θ value	1.38821 (rank : 91)
Query Neighborhood Hits	157	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q10570, Q96AF0	Gene names	CPSF1, CPSF160
Domain Architecture
Description	Cleavage and polyadenylation specificity factor 160 kDa subunit (CPSF 160 kDa subunit).

ANR26_HUMAN
NC score	0.010768 (rank : 135)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	157	Target Neighborhood Hits	1614	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

NUMA1_HUMAN
NC score	0.010687 (rank : 136)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	157	Target Neighborhood Hits	1523	Shared Neighborhood Hits	43
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

MY18A_HUMAN
NC score	0.009905 (rank : 137)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	157	Target Neighborhood Hits	1929	Shared Neighborhood Hits	51
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

AT5F1_HUMAN
NC score	0.009683 (rank : 138)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	157	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P24539, Q9BQ68, Q9BRU8	Gene names	ATP5F1
Domain Architecture
Description	ATP synthase B chain, mitochondrial precursor (EC 3.6.3.14).

RIMB1_HUMAN
NC score	0.009421 (rank : 139)	θ value	5.27518 (rank : 130)
Query Neighborhood Hits	157	Target Neighborhood Hits	1479	Shared Neighborhood Hits	38
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CYLN2_MOUSE
NC score	0.009286 (rank : 140)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	157	Target Neighborhood Hits	1002	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

MYPT1_HUMAN
NC score	0.008915 (rank : 141)	θ value	0.21417 (rank : 63)
Query Neighborhood Hits	157	Target Neighborhood Hits	723	Shared Neighborhood Hits	28
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

MYPT1_MOUSE
NC score	0.008853 (rank : 142)	θ value	0.163984 (rank : 61)
Query Neighborhood Hits	157	Target Neighborhood Hits	539	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

ABRA_MOUSE
NC score	0.007625 (rank : 143)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	157	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BUZ1, Q3UU01, Q8BLH3, Q8K431	Gene names	Abra
Domain Architecture	No domain graphic available
Description	Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS).

DMP1_MOUSE
NC score	0.007443 (rank : 144)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	157	Target Neighborhood Hits	498	Shared Neighborhood Hits	18
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

AF9_HUMAN
NC score	0.006853 (rank : 145)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	157	Target Neighborhood Hits	202	Shared Neighborhood Hits	11
SwissProt Accessions	P42568	Gene names	MLLT3, AF9, YEATS3
Domain Architecture
Description	Protein AF-9 (ALL1 fused gene from chromosome 9 protein) (Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein) (YEATS domain-containing protein 3).

CY15A_HUMAN
NC score	0.006645 (rank : 146)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	157	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZA5	Gene names	CYorf15A
Domain Architecture	No domain graphic available
Description	Putative testis protein CYorf15A.

NGAP_HUMAN
NC score	0.006461 (rank : 147)	θ value	6.88961 (rank : 140)
Query Neighborhood Hits	157	Target Neighborhood Hits	517	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UJF2, O95174, Q5TFU9	Gene names	RASAL2, NGAP
Domain Architecture
Description	Ras GTPase-activating protein nGAP (RAS protein activator-like 1).

CENPE_HUMAN
NC score	0.006453 (rank : 148)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	157	Target Neighborhood Hits	2060	Shared Neighborhood Hits	44
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

NKTR_HUMAN
NC score	0.006332 (rank : 149)	θ value	2.36792 (rank : 104)
Query Neighborhood Hits	157	Target Neighborhood Hits	658	Shared Neighborhood Hits	28
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

MARH4_HUMAN
NC score	0.005919 (rank : 150)	θ value	6.88961 (rank : 139)
Query Neighborhood Hits	157	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2E8, Q86WR8	Gene names	MARCH4, KIAA1399, RNF174
Domain Architecture	No domain graphic available
Description	Membrane-associated RING finger protein 4 (Membrane-associated RING-CH protein IV) (MARCH-IV) (RING finger protein 174).

K0831_HUMAN
NC score	0.005916 (rank : 151)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	157	Target Neighborhood Hits	203	Shared Neighborhood Hits	19
SwissProt Accessions	Q6ZNE5, O94920	Gene names	KIAA0831
Domain Architecture	No domain graphic available
Description	Protein KIAA0831.

ATF6B_MOUSE
NC score	0.005741 (rank : 152)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	157	Target Neighborhood Hits	97	Shared Neighborhood Hits	4
SwissProt Accessions	O35451	Gene names	Crebl1
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-6 beta (Activating transcription factor 6 beta) (ATF6-beta) (cAMP-responsive element- binding protein-like 1) (cAMP response element-binding protein-related protein) (Creb-rp).

PSD4_HUMAN
NC score	0.005063 (rank : 153)	θ value	6.88961 (rank : 142)
Query Neighborhood Hits	157	Target Neighborhood Hits	178	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

TBX3_HUMAN
NC score	0.004901 (rank : 154)	θ value	0.813845 (rank : 80)
Query Neighborhood Hits	157	Target Neighborhood Hits	121	Shared Neighborhood Hits	2
SwissProt Accessions	O15119, Q8TB20, Q9UKF8	Gene names	TBX3
Domain Architecture
Description	T-box transcription factor TBX3 (T-box protein 3).

LAD1_HUMAN
NC score	0.004270 (rank : 155)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	157	Target Neighborhood Hits	441	Shared Neighborhood Hits	12
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

DIP2A_MOUSE
NC score	0.004228 (rank : 156)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	157	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BWT5, Q8CHI0	Gene names	Dip2a, Dip2, Kiaa0184
Domain Architecture
Description	Disco-interacting protein 2 homolog A.

ANK3_HUMAN
NC score	0.004079 (rank : 157)	θ value	1.06291 (rank : 83)
Query Neighborhood Hits	157	Target Neighborhood Hits	853	Shared Neighborhood Hits	34
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANPRB_MOUSE
NC score	0.003307 (rank : 158)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	157	Target Neighborhood Hits	607	Shared Neighborhood Hits	5
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

GASP2_MOUSE
NC score	0.003231 (rank : 159)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	157	Target Neighborhood Hits	228	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BUY8	Gene names	Gprasp2
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor-associated sorting protein 2 (GASP-2).

SON_HUMAN
NC score	0.003182 (rank : 160)	θ value	2.36792 (rank : 105)
Query Neighborhood Hits	157	Target Neighborhood Hits	1568	Shared Neighborhood Hits	21
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

PI2R_HUMAN
NC score	0.003070 (rank : 161)	θ value	6.88961 (rank : 141)
Query Neighborhood Hits	157	Target Neighborhood Hits	290	Shared Neighborhood Hits	6
SwissProt Accessions	P43119	Gene names	PTGIR, PRIPR
Domain Architecture
Description	Prostacyclin receptor (Prostanoid IP receptor) (PGI receptor) (Prostaglandin I2 receptor).

ANPRB_HUMAN
NC score	0.002796 (rank : 162)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	157	Target Neighborhood Hits	646	Shared Neighborhood Hits	5
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ANPRA_MOUSE
NC score	0.002516 (rank : 163)	θ value	2.36792 (rank : 101)
Query Neighborhood Hits	157	Target Neighborhood Hits	600	Shared Neighborhood Hits	5
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_HUMAN
NC score	0.002513 (rank : 164)	θ value	2.36792 (rank : 100)
Query Neighborhood Hits	157	Target Neighborhood Hits	612	Shared Neighborhood Hits	5
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

LYST_HUMAN
NC score	0.002366 (rank : 165)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	157	Target Neighborhood Hits	324	Shared Neighborhood Hits	7
SwissProt Accessions	Q99698, O43274, Q5T2U9, Q96TD7, Q96TD8, Q99709, Q9H133	Gene names	LYST, CHS, CHS1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige homolog).

MPP4_HUMAN
NC score	0.000872 (rank : 166)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	157	Target Neighborhood Hits	205	Shared Neighborhood Hits	4
SwissProt Accessions	Q96JB8, Q6ZNH6, Q96Q43, Q96Q44	Gene names	MPP4, ALS2CR5, DLG6
Domain Architecture
Description	MAGUK p55 subfamily member 4 (Discs large homolog 6) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein).

KIF1B_MOUSE
NC score	0.000653 (rank : 167)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	157	Target Neighborhood Hits	167	Shared Neighborhood Hits	10
SwissProt Accessions	Q60575, Q9R0B4, Q9WVE5, Q9Z119	Gene names	Kif1b
Domain Architecture
Description	Kinesin-like protein KIF1B.

AT1A2_MOUSE
NC score	0.000521 (rank : 168)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	157	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PIE5	Gene names	Atp1a2
Domain Architecture	No domain graphic available
Description	Sodium/potassium-transporting ATPase alpha-2 chain precursor (EC 3.6.3.9) (Sodium pump 2) (Na+/K+ ATPase 2) (Alpha(+)).

HRH1_HUMAN
NC score	-0.001023 (rank : 169)	θ value	2.36792 (rank : 103)
Query Neighborhood Hits	157	Target Neighborhood Hits	916	Shared Neighborhood Hits	7
SwissProt Accessions	P35367	Gene names	HRH1
Domain Architecture
Description	Histamine H1 receptor.

LGR4_HUMAN
NC score	-0.001168 (rank : 170)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	157	Target Neighborhood Hits	481	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXB1, Q9NYD1	Gene names	LGR4, GPR48
Domain Architecture
Description	Leucine-rich repeat-containing G-protein coupled receptor 4 precursor (G-protein coupled receptor 48).

OLF9_MOUSE
NC score	-0.001771 (rank : 171)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	157	Target Neighborhood Hits	700	Shared Neighborhood Hits	13
SwissProt Accessions	Q60885, Q8VGC0	Gene names	Olfr9, Mor269-3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 9 (Olfactory receptor 269-3) (Odorant receptor M25).

OX2R_HUMAN
NC score	-0.002590 (rank : 172)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	157	Target Neighborhood Hits	929	Shared Neighborhood Hits	8
SwissProt Accessions	O43614	Gene names	HCRTR2
Domain Architecture
Description	Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2).

OX2R_MOUSE
NC score	-0.002616 (rank : 173)	θ value	5.27518 (rank : 129)
Query Neighborhood Hits	157	Target Neighborhood Hits	921	Shared Neighborhood Hits	7
SwissProt Accessions	P58308, Q5SGC8, Q6VLX3, Q8BG12	Gene names	Hcrtr2, Mox2r
Domain Architecture
Description	Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2).

KLF5_HUMAN
NC score	-0.005019 (rank : 174)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	157	Target Neighborhood Hits	727	Shared Neighborhood Hits	3
SwissProt Accessions	Q13887, Q9UHP8	Gene names	KLF5, BTEB2, CKLF, IKLF
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 5 (Intestinal-enriched krueppel-like factor) (Colon krueppel-like factor) (Transcription factor BTEB2) (Basic transcription element-binding protein 2) (BTE-binding protein 2) (GC box-binding protein 2).

ZN184_HUMAN
NC score	-0.005540 (rank : 175)	θ value	8.99809 (rank : 157)
Query Neighborhood Hits	157	Target Neighborhood Hits	811	Shared Neighborhood Hits	4
SwissProt Accessions	Q99676, O60792, Q8TBA9	Gene names	ZNF184
Domain Architecture
Description	Zinc finger protein 184.