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Network neighborhood for query Sequence : SCN3A_HUMAN

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SCN3A_HUMAN
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SC10A_HUMAN
θ value	0 (rank : 1)	NC score	0.993277 (rank : 8)
Query Neighborhood Hits	115	Target Neighborhood Hits	116	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
θ value	0 (rank : 2)	NC score	0.993443 (rank : 7)
Query Neighborhood Hits	115	Target Neighborhood Hits	107	Shared Neighborhood Hits	66
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC11A_HUMAN
θ value	0 (rank : 3)	NC score	0.984974 (rank : 13)
Query Neighborhood Hits	115	Target Neighborhood Hits	111	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC11A_MOUSE
θ value	0 (rank : 4)	NC score	0.987088 (rank : 11)
Query Neighborhood Hits	115	Target Neighborhood Hits	116	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN1A_HUMAN
θ value	0 (rank : 5)	NC score	0.996482 (rank : 3)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	80
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0 (rank : 6)	NC score	0.997439 (rank : 2)
Query Neighborhood Hits	115	Target Neighborhood Hits	157	Shared Neighborhood Hits	82
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
θ value	0 (rank : 7)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
θ value	0 (rank : 8)	NC score	0.992907 (rank : 9)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	68
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
θ value	0 (rank : 9)	NC score	0.988193 (rank : 10)
Query Neighborhood Hits	115	Target Neighborhood Hits	145	Shared Neighborhood Hits	70
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN7A_HUMAN
θ value	0 (rank : 10)	NC score	0.986449 (rank : 12)
Query Neighborhood Hits	115	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN8A_HUMAN
θ value	0 (rank : 11)	NC score	0.994894 (rank : 6)
Query Neighborhood Hits	115	Target Neighborhood Hits	135	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	0 (rank : 12)	NC score	0.995287 (rank : 5)
Query Neighborhood Hits	115	Target Neighborhood Hits	136	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN9A_HUMAN
θ value	0 (rank : 13)	NC score	0.995789 (rank : 4)
Query Neighborhood Hits	115	Target Neighborhood Hits	157	Shared Neighborhood Hits	75
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

CAC1I_HUMAN
θ value	5.8972e-76 (rank : 14)	NC score	0.897325 (rank : 14)
Query Neighborhood Hits	115	Target Neighborhood Hits	138	Shared Neighborhood Hits	58
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1D_HUMAN
θ value	3.23591e-74 (rank : 15)	NC score	0.849178 (rank : 22)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	59
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1H_MOUSE
θ value	2.73936e-73 (rank : 16)	NC score	0.877256 (rank : 15)
Query Neighborhood Hits	115	Target Neighborhood Hits	230	Shared Neighborhood Hits	59
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1S_MOUSE
θ value	6.10265e-73 (rank : 17)	NC score	0.849771 (rank : 21)
Query Neighborhood Hits	115	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1H_HUMAN
θ value	2.31901e-72 (rank : 18)	NC score	0.870292 (rank : 16)
Query Neighborhood Hits	115	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1A_MOUSE
θ value	9.74306e-71 (rank : 19)	NC score	0.853748 (rank : 19)
Query Neighborhood Hits	115	Target Neighborhood Hits	267	Shared Neighborhood Hits	59
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1G_HUMAN
θ value	1.27248e-70 (rank : 20)	NC score	0.853204 (rank : 20)
Query Neighborhood Hits	115	Target Neighborhood Hits	587	Shared Neighborhood Hits	60
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1S_HUMAN
θ value	1.27248e-70 (rank : 21)	NC score	0.848750 (rank : 23)
Query Neighborhood Hits	115	Target Neighborhood Hits	92	Shared Neighborhood Hits	55
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1C_MOUSE
θ value	6.31527e-70 (rank : 22)	NC score	0.842073 (rank : 29)
Query Neighborhood Hits	115	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1F_MOUSE
θ value	6.31527e-70 (rank : 23)	NC score	0.843954 (rank : 27)
Query Neighborhood Hits	115	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
θ value	1.83746e-69 (rank : 24)	NC score	0.843151 (rank : 28)
Query Neighborhood Hits	115	Target Neighborhood Hits	141	Shared Neighborhood Hits	58
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1A_HUMAN
θ value	4.09345e-69 (rank : 25)	NC score	0.846170 (rank : 25)
Query Neighborhood Hits	115	Target Neighborhood Hits	387	Shared Neighborhood Hits	59
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
θ value	9.11921e-69 (rank : 26)	NC score	0.844276 (rank : 26)
Query Neighborhood Hits	115	Target Neighborhood Hits	351	Shared Neighborhood Hits	57
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1E_HUMAN
θ value	1.19101e-68 (rank : 27)	NC score	0.857852 (rank : 18)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	1.5555e-68 (rank : 28)	NC score	0.858264 (rank : 17)
Query Neighborhood Hits	115	Target Neighborhood Hits	167	Shared Neighborhood Hits	59
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1C_HUMAN
θ value	6.11685e-65 (rank : 29)	NC score	0.836907 (rank : 30)
Query Neighborhood Hits	115	Target Neighborhood Hits	158	Shared Neighborhood Hits	57
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1B_HUMAN
θ value	3.96481e-64 (rank : 30)	NC score	0.847147 (rank : 24)
Query Neighborhood Hits	115	Target Neighborhood Hits	257	Shared Neighborhood Hits	54
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

KCNB2_HUMAN
θ value	3.41135e-07 (rank : 31)	NC score	0.217044 (rank : 37)
Query Neighborhood Hits	115	Target Neighborhood Hits	212	Shared Neighborhood Hits	51
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNB1_HUMAN
θ value	4.1701e-05 (rank : 32)	NC score	0.197172 (rank : 42)
Query Neighborhood Hits	115	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	4.1701e-05 (rank : 33)	NC score	0.197248 (rank : 41)
Query Neighborhood Hits	115	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNF1_HUMAN
θ value	9.29e-05 (rank : 34)	NC score	0.231892 (rank : 36)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCND3_HUMAN
θ value	0.000786445 (rank : 35)	NC score	0.177897 (rank : 44)
Query Neighborhood Hits	115	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.000786445 (rank : 36)	NC score	0.178004 (rank : 43)
Query Neighborhood Hits	115	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNV2_HUMAN
θ value	0.00102713 (rank : 37)	NC score	0.215662 (rank : 38)
Query Neighborhood Hits	115	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNS2_MOUSE
θ value	0.00509761 (rank : 38)	NC score	0.206876 (rank : 39)
Query Neighborhood Hits	115	Target Neighborhood Hits	130	Shared Neighborhood Hits	52
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS3_HUMAN
θ value	0.00665767 (rank : 39)	NC score	0.175762 (rank : 45)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND2_HUMAN
θ value	0.00869519 (rank : 40)	NC score	0.170234 (rank : 47)
Query Neighborhood Hits	115	Target Neighborhood Hits	154	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.00869519 (rank : 41)	NC score	0.170400 (rank : 46)
Query Neighborhood Hits	115	Target Neighborhood Hits	156	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCNS2_HUMAN
θ value	0.00869519 (rank : 42)	NC score	0.201634 (rank : 40)
Query Neighborhood Hits	115	Target Neighborhood Hits	129	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

PK2L1_HUMAN
θ value	0.0193708 (rank : 43)	NC score	0.280660 (rank : 32)
Query Neighborhood Hits	115	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
θ value	0.0193708 (rank : 44)	NC score	0.268337 (rank : 33)
Query Neighborhood Hits	115	Target Neighborhood Hits	84	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_HUMAN
θ value	0.0193708 (rank : 45)	NC score	0.260187 (rank : 35)
Query Neighborhood Hits	115	Target Neighborhood Hits	105	Shared Neighborhood Hits	44
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PK2L2_HUMAN
θ value	0.0252991 (rank : 46)	NC score	0.303270 (rank : 31)
Query Neighborhood Hits	115	Target Neighborhood Hits	90	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

TRPV3_HUMAN
θ value	0.0330416 (rank : 47)	NC score	0.094457 (rank : 61)
Query Neighborhood Hits	115	Target Neighborhood Hits	198	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

KCND1_MOUSE
θ value	0.0431538 (rank : 48)	NC score	0.151712 (rank : 48)
Query Neighborhood Hits	115	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

TRPC1_HUMAN
θ value	0.0431538 (rank : 49)	NC score	0.068828 (rank : 77)
Query Neighborhood Hits	115	Target Neighborhood Hits	91	Shared Neighborhood Hits	18
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	0.0431538 (rank : 50)	NC score	0.068914 (rank : 76)
Query Neighborhood Hits	115	Target Neighborhood Hits	87	Shared Neighborhood Hits	18
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TPTE2_HUMAN
θ value	0.0563607 (rank : 51)	NC score	0.146835 (rank : 50)
Query Neighborhood Hits	115	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCND1_HUMAN
θ value	0.0961366 (rank : 52)	NC score	0.149877 (rank : 49)
Query Neighborhood Hits	115	Target Neighborhood Hits	160	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

TPTE_HUMAN
θ value	0.0961366 (rank : 53)	NC score	0.102931 (rank : 60)
Query Neighborhood Hits	115	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

CABP5_HUMAN
θ value	0.163984 (rank : 54)	NC score	0.043398 (rank : 90)
Query Neighborhood Hits	115	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

CABP5_MOUSE
θ value	0.163984 (rank : 55)	NC score	0.058903 (rank : 86)
Query Neighborhood Hits	115	Target Neighborhood Hits	207	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KCNC1_HUMAN
θ value	0.21417 (rank : 56)	NC score	0.142244 (rank : 51)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	47
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

PKD2_MOUSE
θ value	0.21417 (rank : 57)	NC score	0.263264 (rank : 34)
Query Neighborhood Hits	115	Target Neighborhood Hits	99	Shared Neighborhood Hits	44
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PSN2_MOUSE
θ value	0.21417 (rank : 58)	NC score	0.041427 (rank : 91)
Query Neighborhood Hits	115	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

KCNC1_MOUSE
θ value	0.279714 (rank : 59)	NC score	0.139931 (rank : 52)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	47
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

ANR26_HUMAN
θ value	0.47712 (rank : 60)	NC score	0.002665 (rank : 122)
Query Neighborhood Hits	115	Target Neighborhood Hits	1614	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

PKDRE_HUMAN
θ value	0.47712 (rank : 61)	NC score	0.118674 (rank : 56)
Query Neighborhood Hits	115	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TRPV3_MOUSE
θ value	0.47712 (rank : 62)	NC score	0.065709 (rank : 80)
Query Neighborhood Hits	115	Target Neighborhood Hits	188	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

GOGA4_HUMAN
θ value	0.62314 (rank : 63)	NC score	0.003785 (rank : 121)
Query Neighborhood Hits	115	Target Neighborhood Hits	2034	Shared Neighborhood Hits	23
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

KCNS1_HUMAN
θ value	0.62314 (rank : 64)	NC score	0.139352 (rank : 53)
Query Neighborhood Hits	115	Target Neighborhood Hits	116	Shared Neighborhood Hits	50
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

PKDRE_MOUSE
θ value	0.62314 (rank : 65)	NC score	0.093052 (rank : 62)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

F261_HUMAN
θ value	0.813845 (rank : 66)	NC score	0.010133 (rank : 99)
Query Neighborhood Hits	115	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

TRAF5_HUMAN
θ value	1.06291 (rank : 67)	NC score	0.006010 (rank : 109)
Query Neighborhood Hits	115	Target Neighborhood Hits	396	Shared Neighborhood Hits	8
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

KCNC3_HUMAN
θ value	1.38821 (rank : 68)	NC score	0.115595 (rank : 58)
Query Neighborhood Hits	115	Target Neighborhood Hits	256	Shared Neighborhood Hits	45
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

SYT14_HUMAN
θ value	1.38821 (rank : 69)	NC score	0.006083 (rank : 108)
Query Neighborhood Hits	115	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

TRPV4_HUMAN
θ value	1.38821 (rank : 70)	NC score	0.060686 (rank : 84)
Query Neighborhood Hits	115	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	1.38821 (rank : 71)	NC score	0.062145 (rank : 83)
Query Neighborhood Hits	115	Target Neighborhood Hits	117	Shared Neighborhood Hits	24
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

GOGA2_MOUSE
θ value	1.81305 (rank : 72)	NC score	0.009996 (rank : 101)
Query Neighborhood Hits	115	Target Neighborhood Hits	944	Shared Neighborhood Hits	20
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

KCNC3_MOUSE
θ value	1.81305 (rank : 73)	NC score	0.113564 (rank : 59)
Query Neighborhood Hits	115	Target Neighborhood Hits	173	Shared Neighborhood Hits	45
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

PSN2_HUMAN
θ value	1.81305 (rank : 74)	NC score	0.015977 (rank : 94)
Query Neighborhood Hits	115	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

STK10_HUMAN
θ value	1.81305 (rank : 75)	NC score	-0.000766 (rank : 133)
Query Neighborhood Hits	115	Target Neighborhood Hits	1921	Shared Neighborhood Hits	17
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

TRIPB_HUMAN
θ value	1.81305 (rank : 76)	NC score	0.002013 (rank : 126)
Query Neighborhood Hits	115	Target Neighborhood Hits	1587	Shared Neighborhood Hits	20
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

AP3B1_HUMAN
θ value	2.36792 (rank : 77)	NC score	0.004730 (rank : 115)
Query Neighborhood Hits	115	Target Neighborhood Hits	283	Shared Neighborhood Hits	6
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

RN183_MOUSE
θ value	2.36792 (rank : 78)	NC score	0.009461 (rank : 102)
Query Neighborhood Hits	115	Target Neighborhood Hits	119	Shared Neighborhood Hits	2
SwissProt Accessions	Q8QZS5, Q5NBV8	Gene names	Rnf183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

AIOL_MOUSE
θ value	3.0926 (rank : 79)	NC score	-0.004259 (rank : 137)
Query Neighborhood Hits	115	Target Neighborhood Hits	759	Shared Neighborhood Hits	4
SwissProt Accessions	O08900	Gene names	Ikzf3, Zfpn1a3, Znfn1a3
Domain Architecture	No domain graphic available
Description	Zinc finger protein Aiolos (IKAROS family zinc finger protein 3).

KCNC4_HUMAN
θ value	3.0926 (rank : 80)	NC score	0.123246 (rank : 54)
Query Neighborhood Hits	115	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
θ value	3.0926 (rank : 81)	NC score	0.116435 (rank : 57)
Query Neighborhood Hits	115	Target Neighborhood Hits	130	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

CENPI_MOUSE
θ value	4.03905 (rank : 82)	NC score	0.008301 (rank : 103)
Query Neighborhood Hits	115	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K1K4, Q8BXU9	Gene names	Cenpi, Fshprh1
Domain Architecture	No domain graphic available
Description	Centromere protein I (CENP-I) (Follicle-stimulating hormone primary response protein) (FSH primary response protein 1).

DDX49_HUMAN
θ value	4.03905 (rank : 83)	NC score	0.010058 (rank : 100)
Query Neighborhood Hits	115	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

DIAP2_HUMAN
θ value	4.03905 (rank : 84)	NC score	0.010683 (rank : 98)
Query Neighborhood Hits	115	Target Neighborhood Hits	342	Shared Neighborhood Hits	11
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

ITSN1_MOUSE
θ value	4.03905 (rank : 85)	NC score	0.000663 (rank : 132)
Query Neighborhood Hits	115	Target Neighborhood Hits	1669	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

LRC48_HUMAN
θ value	4.03905 (rank : 86)	NC score	0.004379 (rank : 117)
Query Neighborhood Hits	115	Target Neighborhood Hits	324	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H069, Q86SF9, Q86W73, Q8IWG0	Gene names	LRRC48
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 48.

PITM2_MOUSE
θ value	4.03905 (rank : 87)	NC score	0.003986 (rank : 119)
Query Neighborhood Hits	115	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPQ6, Q9R1P5	Gene names	Pitpnm2, Kiaa1457, Nir3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) (Drosophila retinal degeneration B homolog 2) (RdgB2).

STK10_MOUSE
θ value	4.03905 (rank : 88)	NC score	-0.000912 (rank : 134)
Query Neighborhood Hits	115	Target Neighborhood Hits	2132	Shared Neighborhood Hits	22
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

SYNG_MOUSE
θ value	4.03905 (rank : 89)	NC score	0.006678 (rank : 107)
Query Neighborhood Hits	115	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

A16L1_MOUSE
θ value	5.27518 (rank : 90)	NC score	0.008029 (rank : 104)
Query Neighborhood Hits	115	Target Neighborhood Hits	776	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

CABL2_MOUSE
θ value	5.27518 (rank : 91)	NC score	0.005285 (rank : 114)
Query Neighborhood Hits	115	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

CROCC_MOUSE
θ value	5.27518 (rank : 92)	NC score	0.002240 (rank : 123)
Query Neighborhood Hits	115	Target Neighborhood Hits	1460	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

MRP3_HUMAN
θ value	5.27518 (rank : 93)	NC score	0.000815 (rank : 131)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	O15438, O60265, O60922, O75621, O95078, O95289, O95290, Q9UN52	Gene names	ABCC3, CMOAT2, MLP2, MRP3
Domain Architecture
Description	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D).

MYCL2_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.005454 (rank : 112)
Query Neighborhood Hits	115	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

TACC2_HUMAN
θ value	5.27518 (rank : 95)	NC score	0.001123 (rank : 130)
Query Neighborhood Hits	115	Target Neighborhood Hits	856	Shared Neighborhood Hits	11
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TLR1_MOUSE
θ value	5.27518 (rank : 96)	NC score	0.001502 (rank : 129)
Query Neighborhood Hits	115	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPQ1, Q9EPW5	Gene names	Tlr1
Domain Architecture
Description	Toll-like receptor 1 precursor (Toll/interleukin-1 receptor-like protein) (TIL) (CD281 antigen).

TLR6_MOUSE
θ value	5.27518 (rank : 97)	NC score	0.001516 (rank : 128)
Query Neighborhood Hits	115	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPW9, Q9WTQ4	Gene names	Tlr6
Domain Architecture
Description	Toll-like receptor 6 precursor.

TPR_HUMAN
θ value	5.27518 (rank : 98)	NC score	0.002117 (rank : 124)
Query Neighborhood Hits	115	Target Neighborhood Hits	1921	Shared Neighborhood Hits	25
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

ABCA6_HUMAN
θ value	6.88961 (rank : 99)	NC score	0.001805 (rank : 127)
Query Neighborhood Hits	115	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N139, Q6NSH9, Q8N856, Q8WWZ6	Gene names	ABCA6
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 6.

AMPE_HUMAN
θ value	6.88961 (rank : 100)	NC score	0.002109 (rank : 125)
Query Neighborhood Hits	115	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

ARI4A_HUMAN
θ value	6.88961 (rank : 101)	NC score	0.004442 (rank : 116)
Query Neighborhood Hits	115	Target Neighborhood Hits	434	Shared Neighborhood Hits	12
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

SIRT1_MOUSE
θ value	6.88961 (rank : 102)	NC score	0.005972 (rank : 110)
Query Neighborhood Hits	115	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

TARA_HUMAN
θ value	6.88961 (rank : 103)	NC score	0.015416 (rank : 95)
Query Neighborhood Hits	115	Target Neighborhood Hits	1626	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

BORG1_HUMAN
θ value	8.99809 (rank : 104)	NC score	0.005446 (rank : 113)
Query Neighborhood Hits	115	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	O14613, Q9UNS0	Gene names	CDC42EP2, BORG1, CEP2
Domain Architecture	No domain graphic available
Description	Cdc42 effector protein 2 (Binder of Rho GTPases 1).

BORG1_MOUSE
θ value	8.99809 (rank : 105)	NC score	0.005951 (rank : 111)
Query Neighborhood Hits	115	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZX9	Gene names	Cdc42ep2, Borg1, Cep2
Domain Architecture	No domain graphic available
Description	Cdc42 effector protein 2 (Binder of Rho GTPases 1).

CALB2_HUMAN
θ value	8.99809 (rank : 106)	NC score	0.020104 (rank : 93)
Query Neighborhood Hits	115	Target Neighborhood Hits	149	Shared Neighborhood Hits	15
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

CALB2_MOUSE
θ value	8.99809 (rank : 107)	NC score	0.020468 (rank : 92)
Query Neighborhood Hits	115	Target Neighborhood Hits	141	Shared Neighborhood Hits	16
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

ITPR1_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.007541 (rank : 105)
Query Neighborhood Hits	115	Target Neighborhood Hits	90	Shared Neighborhood Hits	9
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
θ value	8.99809 (rank : 109)	NC score	0.007528 (rank : 106)
Query Neighborhood Hits	115	Target Neighborhood Hits	99	Shared Neighborhood Hits	9
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

MAX_MOUSE
θ value	8.99809 (rank : 110)	NC score	0.004108 (rank : 118)
Query Neighborhood Hits	115	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

NUCKS_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.012299 (rank : 97)
Query Neighborhood Hits	115	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XU3, Q8BVD8	Gene names	Nucks1, Nucks
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (JC7).

OLF9_MOUSE
θ value	8.99809 (rank : 112)	NC score	-0.001635 (rank : 135)
Query Neighborhood Hits	115	Target Neighborhood Hits	700	Shared Neighborhood Hits	9
SwissProt Accessions	Q60885, Q8VGC0	Gene names	Olfr9, Mor269-3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 9 (Olfactory receptor 269-3) (Odorant receptor M25).

PHF3_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.003961 (rank : 120)
Query Neighborhood Hits	115	Target Neighborhood Hits	419	Shared Neighborhood Hits	9
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

SEGN_HUMAN
θ value	8.99809 (rank : 114)	NC score	0.015035 (rank : 96)
Query Neighborhood Hits	115	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	O76038, Q5VV44, Q96QV7, Q9UJF6	Gene names	SCGN, SECRET
Domain Architecture
Description	Secretagogin.

TMPS6_HUMAN
θ value	8.99809 (rank : 115)	NC score	-0.002268 (rank : 136)
Query Neighborhood Hits	115	Target Neighborhood Hits	338	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

KCNA1_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.078782 (rank : 66)
Query Neighborhood Hits	115	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA1_MOUSE
θ value	θ > 10 (rank : 117)	NC score	0.080157 (rank : 65)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	35
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA2_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.077059 (rank : 68)
Query Neighborhood Hits	115	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA2_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.077889 (rank : 67)
Query Neighborhood Hits	115	Target Neighborhood Hits	102	Shared Neighborhood Hits	32
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA3_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.069899 (rank : 74)
Query Neighborhood Hits	115	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.069049 (rank : 75)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA4_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.056545 (rank : 88)
Query Neighborhood Hits	115	Target Neighborhood Hits	108	Shared Neighborhood Hits	23
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.056937 (rank : 87)
Query Neighborhood Hits	115	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA5_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.066096 (rank : 79)
Query Neighborhood Hits	115	Target Neighborhood Hits	124	Shared Neighborhood Hits	27
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.071288 (rank : 72)
Query Neighborhood Hits	115	Target Neighborhood Hits	119	Shared Neighborhood Hits	31
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA6_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.071993 (rank : 71)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	31
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA6_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.074858 (rank : 70)
Query Neighborhood Hits	115	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG1_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.071214 (rank : 73)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNG2_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.064896 (rank : 81)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG3_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.091211 (rank : 64)
Query Neighborhood Hits	115	Target Neighborhood Hits	91	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.091655 (rank : 63)
Query Neighborhood Hits	115	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG4_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.063312 (rank : 82)
Query Neighborhood Hits	115	Target Neighborhood Hits	99	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.059853 (rank : 85)
Query Neighborhood Hits	115	Target Neighborhood Hits	99	Shared Neighborhood Hits	28
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ1_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.068056 (rank : 78)
Query Neighborhood Hits	115	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ4_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.076336 (rank : 69)
Query Neighborhood Hits	115	Target Neighborhood Hits	136	Shared Neighborhood Hits	34
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNQ5_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.054000 (rank : 89)
Query Neighborhood Hits	115	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

KCNS1_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.121064 (rank : 55)
Query Neighborhood Hits	115	Target Neighborhood Hits	114	Shared Neighborhood Hits	44
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

Hits sorted by NC score

SCN3A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 7)
Query Neighborhood Hits	115	Target Neighborhood Hits	115	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN2A_HUMAN
NC score	0.997439 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	115	Target Neighborhood Hits	157	Shared Neighborhood Hits	82
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN1A_HUMAN
NC score	0.996482 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	80
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN9A_HUMAN
NC score	0.995789 (rank : 4)	θ value	0 (rank : 13)
Query Neighborhood Hits	115	Target Neighborhood Hits	157	Shared Neighborhood Hits	75
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN8A_MOUSE
NC score	0.995287 (rank : 5)	θ value	0 (rank : 12)
Query Neighborhood Hits	115	Target Neighborhood Hits	136	Shared Neighborhood Hits	79
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_HUMAN
NC score	0.994894 (rank : 6)	θ value	0 (rank : 11)
Query Neighborhood Hits	115	Target Neighborhood Hits	135	Shared Neighborhood Hits	78
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SC10A_MOUSE
NC score	0.993443 (rank : 7)	θ value	0 (rank : 2)
Query Neighborhood Hits	115	Target Neighborhood Hits	107	Shared Neighborhood Hits	66
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC10A_HUMAN
NC score	0.993277 (rank : 8)	θ value	0 (rank : 1)
Query Neighborhood Hits	115	Target Neighborhood Hits	116	Shared Neighborhood Hits	63
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN4A_HUMAN
NC score	0.992907 (rank : 9)	θ value	0 (rank : 8)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	68
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
NC score	0.988193 (rank : 10)	θ value	0 (rank : 9)
Query Neighborhood Hits	115	Target Neighborhood Hits	145	Shared Neighborhood Hits	70
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SC11A_MOUSE
NC score	0.987088 (rank : 11)	θ value	0 (rank : 4)
Query Neighborhood Hits	115	Target Neighborhood Hits	116	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN7A_HUMAN
NC score	0.986449 (rank : 12)	θ value	0 (rank : 10)
Query Neighborhood Hits	115	Target Neighborhood Hits	135	Shared Neighborhood Hits	58
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SC11A_HUMAN
NC score	0.984974 (rank : 13)	θ value	0 (rank : 3)
Query Neighborhood Hits	115	Target Neighborhood Hits	111	Shared Neighborhood Hits	64
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

CAC1I_HUMAN
NC score	0.897325 (rank : 14)	θ value	5.8972e-76 (rank : 14)
Query Neighborhood Hits	115	Target Neighborhood Hits	138	Shared Neighborhood Hits	58
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.877256 (rank : 15)	θ value	2.73936e-73 (rank : 16)
Query Neighborhood Hits	115	Target Neighborhood Hits	230	Shared Neighborhood Hits	59
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.870292 (rank : 16)	θ value	2.31901e-72 (rank : 18)
Query Neighborhood Hits	115	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1E_MOUSE
NC score	0.858264 (rank : 17)	θ value	1.5555e-68 (rank : 28)
Query Neighborhood Hits	115	Target Neighborhood Hits	167	Shared Neighborhood Hits	59
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.857852 (rank : 18)	θ value	1.19101e-68 (rank : 27)
Query Neighborhood Hits	115	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1A_MOUSE
NC score	0.853748 (rank : 19)	θ value	9.74306e-71 (rank : 19)
Query Neighborhood Hits	115	Target Neighborhood Hits	267	Shared Neighborhood Hits	59
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1G_HUMAN
NC score	0.853204 (rank : 20)	θ value	1.27248e-70 (rank : 20)
Query Neighborhood Hits	115	Target Neighborhood Hits	587	Shared Neighborhood Hits	60
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1S_MOUSE
NC score	0.849771 (rank : 21)	θ value	6.10265e-73 (rank : 17)
Query Neighborhood Hits	115	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
NC score	0.849178 (rank : 22)	θ value	3.23591e-74 (rank : 15)
Query Neighborhood Hits	115	Target Neighborhood Hits	118	Shared Neighborhood Hits	59
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1S_HUMAN
NC score	0.848750 (rank : 23)	θ value	1.27248e-70 (rank : 21)
Query Neighborhood Hits	115	Target Neighborhood Hits	92	Shared Neighborhood Hits	55
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_HUMAN
NC score	0.847147 (rank : 24)	θ value	3.96481e-64 (rank : 30)
Query Neighborhood Hits	115	Target Neighborhood Hits	257	Shared Neighborhood Hits	54
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_HUMAN
NC score	0.846170 (rank : 25)	θ value	4.09345e-69 (rank : 25)
Query Neighborhood Hits	115	Target Neighborhood Hits	387	Shared Neighborhood Hits	59
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
NC score	0.844276 (rank : 26)	θ value	9.11921e-69 (rank : 26)
Query Neighborhood Hits	115	Target Neighborhood Hits	351	Shared Neighborhood Hits	57
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_MOUSE
NC score	0.843954 (rank : 27)	θ value	6.31527e-70 (rank : 23)
Query Neighborhood Hits	115	Target Neighborhood Hits	142	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.843151 (rank : 28)	θ value	1.83746e-69 (rank : 24)
Query Neighborhood Hits	115	Target Neighborhood Hits	141	Shared Neighborhood Hits	58
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.842073 (rank : 29)	θ value	6.31527e-70 (rank : 22)
Query Neighborhood Hits	115	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.836907 (rank : 30)	θ value	6.11685e-65 (rank : 29)
Query Neighborhood Hits	115	Target Neighborhood Hits	158	Shared Neighborhood Hits	57
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PK2L2_HUMAN
NC score	0.303270 (rank : 31)	θ value	0.0252991 (rank : 46)
Query Neighborhood Hits	115	Target Neighborhood Hits	90	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.280660 (rank : 32)	θ value	0.0193708 (rank : 43)
Query Neighborhood Hits	115	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.268337 (rank : 33)	θ value	0.0193708 (rank : 44)
Query Neighborhood Hits	115	Target Neighborhood Hits	84	Shared Neighborhood Hits	42
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_MOUSE
NC score	0.263264 (rank : 34)	θ value	0.21417 (rank : 57)
Query Neighborhood Hits	115	Target Neighborhood Hits	99	Shared Neighborhood Hits	44
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
NC score	0.260187 (rank : 35)	θ value	0.0193708 (rank : 45)
Query Neighborhood Hits	115	Target Neighborhood Hits	105	Shared Neighborhood Hits	44
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNF1_HUMAN
NC score	0.231892 (rank : 36)	θ value	9.29e-05 (rank : 34)
Query Neighborhood Hits	115	Target Neighborhood Hits	109	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNB2_HUMAN
NC score	0.217044 (rank : 37)	θ value	3.41135e-07 (rank : 31)
Query Neighborhood Hits	115	Target Neighborhood Hits	212	Shared Neighborhood Hits	51
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNV2_HUMAN
NC score	0.215662 (rank : 38)	θ value	0.00102713 (rank : 37)
Query Neighborhood Hits	115	Target Neighborhood Hits	137	Shared Neighborhood Hits	50
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNS2_MOUSE
NC score	0.206876 (rank : 39)	θ value	0.00509761 (rank : 38)
Query Neighborhood Hits	115	Target Neighborhood Hits	130	Shared Neighborhood Hits	52
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
NC score	0.201634 (rank : 40)	θ value	0.00869519 (rank : 42)
Query Neighborhood Hits	115	Target Neighborhood Hits	129	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_MOUSE
NC score	0.197248 (rank : 41)	θ value	4.1701e-05 (rank : 33)
Query Neighborhood Hits	115	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNB1_HUMAN
NC score	0.197172 (rank : 42)	θ value	4.1701e-05 (rank : 32)
Query Neighborhood Hits	115	Target Neighborhood Hits	169	Shared Neighborhood Hits	51
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCND3_MOUSE
NC score	0.178004 (rank : 43)	θ value	0.000786445 (rank : 36)
Query Neighborhood Hits	115	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.177897 (rank : 44)	θ value	0.000786445 (rank : 35)
Query Neighborhood Hits	115	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCNS3_HUMAN
NC score	0.175762 (rank : 45)	θ value	0.00665767 (rank : 39)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	50
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND2_MOUSE
NC score	0.170400 (rank : 46)	θ value	0.00869519 (rank : 41)
Query Neighborhood Hits	115	Target Neighborhood Hits	156	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.170234 (rank : 47)	θ value	0.00869519 (rank : 40)
Query Neighborhood Hits	115	Target Neighborhood Hits	154	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.151712 (rank : 48)	θ value	0.0431538 (rank : 48)
Query Neighborhood Hits	115	Target Neighborhood Hits	165	Shared Neighborhood Hits	51
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.149877 (rank : 49)	θ value	0.0961366 (rank : 52)
Query Neighborhood Hits	115	Target Neighborhood Hits	160	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

TPTE2_HUMAN
NC score	0.146835 (rank : 50)	θ value	0.0563607 (rank : 51)
Query Neighborhood Hits	115	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNC1_HUMAN
NC score	0.142244 (rank : 51)	θ value	0.21417 (rank : 56)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	47
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
NC score	0.139931 (rank : 52)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	115	Target Neighborhood Hits	133	Shared Neighborhood Hits	47
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNS1_HUMAN
NC score	0.139352 (rank : 53)	θ value	0.62314 (rank : 64)
Query Neighborhood Hits	115	Target Neighborhood Hits	116	Shared Neighborhood Hits	50
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC4_HUMAN
NC score	0.123246 (rank : 54)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	115	Target Neighborhood Hits	141	Shared Neighborhood Hits	47
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNS1_MOUSE
NC score	0.121064 (rank : 55)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	115	Target Neighborhood Hits	114	Shared Neighborhood Hits	44
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

PKDRE_HUMAN
NC score	0.118674 (rank : 56)	θ value	0.47712 (rank : 61)
Query Neighborhood Hits	115	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNC4_MOUSE
NC score	0.116435 (rank : 57)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	115	Target Neighborhood Hits	130	Shared Neighborhood Hits	45
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNC3_HUMAN
NC score	0.115595 (rank : 58)	θ value	1.38821 (rank : 68)
Query Neighborhood Hits	115	Target Neighborhood Hits	256	Shared Neighborhood Hits	45
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
NC score	0.113564 (rank : 59)	θ value	1.81305 (rank : 73)
Query Neighborhood Hits	115	Target Neighborhood Hits	173	Shared Neighborhood Hits	45
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

TPTE_HUMAN
NC score	0.102931 (rank : 60)	θ value	0.0961366 (rank : 53)
Query Neighborhood Hits	115	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

TRPV3_HUMAN
NC score	0.094457 (rank : 61)	θ value	0.0330416 (rank : 47)
Query Neighborhood Hits	115	Target Neighborhood Hits	198	Shared Neighborhood Hits	30
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

PKDRE_MOUSE
NC score	0.093052 (rank : 62)	θ value	0.62314 (rank : 65)
Query Neighborhood Hits	115	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNG3_MOUSE
NC score	0.091655 (rank : 63)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	115	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_HUMAN
NC score	0.091211 (rank : 64)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	115	Target Neighborhood Hits	91	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNA1_MOUSE
NC score	0.080157 (rank : 65)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	35
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA1_HUMAN
NC score	0.078782 (rank : 66)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	115	Target Neighborhood Hits	104	Shared Neighborhood Hits	34
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA2_MOUSE
NC score	0.077889 (rank : 67)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	115	Target Neighborhood Hits	102	Shared Neighborhood Hits	32
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA2_HUMAN
NC score	0.077059 (rank : 68)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	115	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNQ4_HUMAN
NC score	0.076336 (rank : 69)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	115	Target Neighborhood Hits	136	Shared Neighborhood Hits	34
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNA6_MOUSE
NC score	0.074858 (rank : 70)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	115	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNA6_HUMAN
NC score	0.071993 (rank : 71)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	115	Target Neighborhood Hits	100	Shared Neighborhood Hits	31
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA5_MOUSE
NC score	0.071288 (rank : 72)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	115	Target Neighborhood Hits	119	Shared Neighborhood Hits	31
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNG1_HUMAN
NC score	0.071214 (rank : 73)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNA3_HUMAN
NC score	0.069899 (rank : 74)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	115	Target Neighborhood Hits	101	Shared Neighborhood Hits	30
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
NC score	0.069049 (rank : 75)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	115	Target Neighborhood Hits	103	Shared Neighborhood Hits	28
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

TRPC1_MOUSE
NC score	0.068914 (rank : 76)	θ value	0.0431538 (rank : 50)
Query Neighborhood Hits	115	Target Neighborhood Hits	87	Shared Neighborhood Hits	18
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.068828 (rank : 77)	θ value	0.0431538 (rank : 49)
Query Neighborhood Hits	115	Target Neighborhood Hits	91	Shared Neighborhood Hits	18
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

KCNQ1_MOUSE
NC score	0.068056 (rank : 78)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	115	Target Neighborhood Hits	175	Shared Neighborhood Hits	32
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA5_HUMAN
NC score	0.066096 (rank : 79)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	115	Target Neighborhood Hits	124	Shared Neighborhood Hits	27
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

TRPV3_MOUSE
NC score	0.065709 (rank : 80)	θ value	0.47712 (rank : 62)
Query Neighborhood Hits	115	Target Neighborhood Hits	188	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

KCNG2_HUMAN
NC score	0.064896 (rank : 81)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	115	Target Neighborhood Hits	83	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG4_HUMAN
NC score	0.063312 (rank : 82)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	115	Target Neighborhood Hits	99	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

TRPV4_MOUSE
NC score	0.062145 (rank : 83)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	115	Target Neighborhood Hits	117	Shared Neighborhood Hits	24
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_HUMAN
NC score	0.060686 (rank : 84)	θ value	1.38821 (rank : 70)
Query Neighborhood Hits	115	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

KCNQ1_HUMAN
NC score	0.059853 (rank : 85)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	115	Target Neighborhood Hits	99	Shared Neighborhood Hits	28
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

CABP5_MOUSE
NC score	0.058903 (rank : 86)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	115	Target Neighborhood Hits	207	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

KCNA4_MOUSE
NC score	0.056937 (rank : 87)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	115	Target Neighborhood Hits	98	Shared Neighborhood Hits	23
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA4_HUMAN
NC score	0.056545 (rank : 88)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	115	Target Neighborhood Hits	108	Shared Neighborhood Hits	23
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNQ5_HUMAN
NC score	0.054000 (rank : 89)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	115	Target Neighborhood Hits	163	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

CABP5_HUMAN
NC score	0.043398 (rank : 90)	θ value	0.163984 (rank : 54)
Query Neighborhood Hits	115	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

PSN2_MOUSE
NC score	0.041427 (rank : 91)	θ value	0.21417 (rank : 58)
Query Neighborhood Hits	115	Target Neighborhood Hits	29	Shared Neighborhood Hits	9
SwissProt Accessions	Q61144, O54977, P97934, P97935, Q91VS3, Q9D616	Gene names	Psen2, Ad4h, Alg3, Ps-2, Psnl2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

CALB2_MOUSE
NC score	0.020468 (rank : 92)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	115	Target Neighborhood Hits	141	Shared Neighborhood Hits	16
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

CALB2_HUMAN
NC score	0.020104 (rank : 93)	θ value	8.99809 (rank : 106)
Query Neighborhood Hits	115	Target Neighborhood Hits	149	Shared Neighborhood Hits	15
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

PSN2_HUMAN
NC score	0.015977 (rank : 94)	θ value	1.81305 (rank : 74)
Query Neighborhood Hits	115	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	P49810, Q96P32	Gene names	PSEN2, AD4, PS2, PSNL2, STM2
Domain Architecture
Description	Presenilin-2 (EC 3.4.23.-) (PS-2) (STM-2) (E5-1) (AD3LP) (AD5) [Contains: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit].

TARA_HUMAN
NC score	0.015416 (rank : 95)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	115	Target Neighborhood Hits	1626	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SEGN_HUMAN
NC score	0.015035 (rank : 96)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	115	Target Neighborhood Hits	96	Shared Neighborhood Hits	8
SwissProt Accessions	O76038, Q5VV44, Q96QV7, Q9UJF6	Gene names	SCGN, SECRET
Domain Architecture
Description	Secretagogin.

NUCKS_MOUSE
NC score	0.012299 (rank : 97)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	115	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q80XU3, Q8BVD8	Gene names	Nucks1, Nucks
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (JC7).

DIAP2_HUMAN
NC score	0.010683 (rank : 98)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	115	Target Neighborhood Hits	342	Shared Neighborhood Hits	11
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

F261_HUMAN
NC score	0.010133 (rank : 99)	θ value	0.813845 (rank : 66)
Query Neighborhood Hits	115	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	P16118, Q99951	Gene names	PFKFB1, F6PK, PFRX
Domain Architecture
Description	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (6PF-2-K/Fru- 2,6-P2ASE liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)].

DDX49_HUMAN
NC score	0.010058 (rank : 100)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	115	Target Neighborhood Hits	223	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6V7, Q53FJ1	Gene names	DDX49
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX49 (EC 3.6.1.-) (DEAD box protein 49).

GOGA2_MOUSE
NC score	0.009996 (rank : 101)	θ value	1.81305 (rank : 72)
Query Neighborhood Hits	115	Target Neighborhood Hits	944	Shared Neighborhood Hits	20
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

RN183_MOUSE
NC score	0.009461 (rank : 102)	θ value	2.36792 (rank : 78)
Query Neighborhood Hits	115	Target Neighborhood Hits	119	Shared Neighborhood Hits	2
SwissProt Accessions	Q8QZS5, Q5NBV8	Gene names	Rnf183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

CENPI_MOUSE
NC score	0.008301 (rank : 103)	θ value	4.03905 (rank : 82)
Query Neighborhood Hits	115	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K1K4, Q8BXU9	Gene names	Cenpi, Fshprh1
Domain Architecture	No domain graphic available
Description	Centromere protein I (CENP-I) (Follicle-stimulating hormone primary response protein) (FSH primary response protein 1).

A16L1_MOUSE
NC score	0.008029 (rank : 104)	θ value	5.27518 (rank : 90)
Query Neighborhood Hits	115	Target Neighborhood Hits	776	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C0J2, Q6KAT7, Q80U97, Q80U98, Q80U99, Q80Y53, Q9DB63	Gene names	Atg16l1, Apg16l
Domain Architecture	No domain graphic available
Description	Autophagy-related protein 16-1 (APG16-like 1).

ITPR1_HUMAN
NC score	0.007541 (rank : 105)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	115	Target Neighborhood Hits	90	Shared Neighborhood Hits	9
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
NC score	0.007528 (rank : 106)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	115	Target Neighborhood Hits	99	Shared Neighborhood Hits	9
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

SYNG_MOUSE
NC score	0.006678 (rank : 107)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	115	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q5SV85, Q5SV84, Q6PHT6	Gene names	Ap1gbp1, Syng
Domain Architecture	No domain graphic available
Description	AP1 subunit gamma-binding protein 1 (Gamma-synergin).

SYT14_HUMAN
NC score	0.006083 (rank : 108)	θ value	1.38821 (rank : 69)
Query Neighborhood Hits	115	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NB59, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7	Gene names	SYT14
Domain Architecture	No domain graphic available
Description	Synaptotagmin-14 (Synaptotagmin XIV) (SytXIV).

TRAF5_HUMAN
NC score	0.006010 (rank : 109)	θ value	1.06291 (rank : 67)
Query Neighborhood Hits	115	Target Neighborhood Hits	396	Shared Neighborhood Hits	8
SwissProt Accessions	O00463	Gene names	TRAF5, RNF84
Domain Architecture
Description	TNF receptor-associated factor 5 (RING finger protein 84).

SIRT1_MOUSE
NC score	0.005972 (rank : 110)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	115	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q923E4, Q9QXG8	Gene names	Sirt1, Sir2l1
Domain Architecture
Description	NAD-dependent deacetylase sirtuin-1 (EC 3.5.1.-) (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1).

BORG1_MOUSE
NC score	0.005951 (rank : 111)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	115	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q8JZX9	Gene names	Cdc42ep2, Borg1, Cep2
Domain Architecture	No domain graphic available
Description	Cdc42 effector protein 2 (Binder of Rho GTPases 1).

MYCL2_HUMAN
NC score	0.005454 (rank : 112)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	115	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

BORG1_HUMAN
NC score	0.005446 (rank : 113)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	115	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	O14613, Q9UNS0	Gene names	CDC42EP2, BORG1, CEP2
Domain Architecture	No domain graphic available
Description	Cdc42 effector protein 2 (Binder of Rho GTPases 1).

CABL2_MOUSE
NC score	0.005285 (rank : 114)	θ value	5.27518 (rank : 91)
Query Neighborhood Hits	115	Target Neighborhood Hits	79	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

AP3B1_HUMAN
NC score	0.004730 (rank : 115)	θ value	2.36792 (rank : 77)
Query Neighborhood Hits	115	Target Neighborhood Hits	283	Shared Neighborhood Hits	6
SwissProt Accessions	O00203, O00580, Q7Z393, Q9HD66	Gene names	AP3B1, ADTB3A
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

ARI4A_HUMAN
NC score	0.004442 (rank : 116)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	115	Target Neighborhood Hits	434	Shared Neighborhood Hits	12
SwissProt Accessions	P29374, Q15991, Q15992, Q15993	Gene names	ARID4A, RBBP1, RBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 4A (ARID domain- containing protein 4A) (Retinoblastoma-binding protein 1) (RBBP-1).

LRC48_HUMAN
NC score	0.004379 (rank : 117)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	115	Target Neighborhood Hits	324	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H069, Q86SF9, Q86W73, Q8IWG0	Gene names	LRRC48
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 48.

MAX_MOUSE
NC score	0.004108 (rank : 118)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	115	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

PITM2_MOUSE
NC score	0.003986 (rank : 119)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	115	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZPQ6, Q9R1P5	Gene names	Pitpnm2, Kiaa1457, Nir3
Domain Architecture	No domain graphic available
Description	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3) (Drosophila retinal degeneration B homolog 2) (RdgB2).

PHF3_HUMAN
NC score	0.003961 (rank : 120)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	115	Target Neighborhood Hits	419	Shared Neighborhood Hits	9
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

GOGA4_HUMAN
NC score	0.003785 (rank : 121)	θ value	0.62314 (rank : 63)
Query Neighborhood Hits	115	Target Neighborhood Hits	2034	Shared Neighborhood Hits	23
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

ANR26_HUMAN
NC score	0.002665 (rank : 122)	θ value	0.47712 (rank : 60)
Query Neighborhood Hits	115	Target Neighborhood Hits	1614	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

CROCC_MOUSE
NC score	0.002240 (rank : 123)	θ value	5.27518 (rank : 92)
Query Neighborhood Hits	115	Target Neighborhood Hits	1460	Shared Neighborhood Hits	20
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

TPR_HUMAN
NC score	0.002117 (rank : 124)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	115	Target Neighborhood Hits	1921	Shared Neighborhood Hits	25
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

AMPE_HUMAN
NC score	0.002109 (rank : 125)	θ value	6.88961 (rank : 100)
Query Neighborhood Hits	115	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q07075	Gene names	ENPEP
Domain Architecture
Description	Glutamyl aminopeptidase (EC 3.4.11.7) (EAP) (Aminopeptidase A) (APA) (Differentiation antigen gp160) (CD249 antigen).

TRIPB_HUMAN
NC score	0.002013 (rank : 126)	θ value	1.81305 (rank : 76)
Query Neighborhood Hits	115	Target Neighborhood Hits	1587	Shared Neighborhood Hits	20
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ABCA6_HUMAN
NC score	0.001805 (rank : 127)	θ value	6.88961 (rank : 99)
Query Neighborhood Hits	115	Target Neighborhood Hits	113	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N139, Q6NSH9, Q8N856, Q8WWZ6	Gene names	ABCA6
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 6.

TLR6_MOUSE
NC score	0.001516 (rank : 128)	θ value	5.27518 (rank : 97)
Query Neighborhood Hits	115	Target Neighborhood Hits	288	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPW9, Q9WTQ4	Gene names	Tlr6
Domain Architecture
Description	Toll-like receptor 6 precursor.

TLR1_MOUSE
NC score	0.001502 (rank : 129)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	115	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPQ1, Q9EPW5	Gene names	Tlr1
Domain Architecture
Description	Toll-like receptor 1 precursor (Toll/interleukin-1 receptor-like protein) (TIL) (CD281 antigen).

TACC2_HUMAN
NC score	0.001123 (rank : 130)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	115	Target Neighborhood Hits	856	Shared Neighborhood Hits	11
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

MRP3_HUMAN
NC score	0.000815 (rank : 131)	θ value	5.27518 (rank : 93)
Query Neighborhood Hits	115	Target Neighborhood Hits	125	Shared Neighborhood Hits	3
SwissProt Accessions	O15438, O60265, O60922, O75621, O95078, O95289, O95290, Q9UN52	Gene names	ABCC3, CMOAT2, MLP2, MRP3
Domain Architecture
Description	Canalicular multispecific organic anion transporter 2 (ATP-binding cassette sub-family C member 3) (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D).

ITSN1_MOUSE
NC score	0.000663 (rank : 132)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	115	Target Neighborhood Hits	1669	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

STK10_HUMAN
NC score	-0.000766 (rank : 133)	θ value	1.81305 (rank : 75)
Query Neighborhood Hits	115	Target Neighborhood Hits	1921	Shared Neighborhood Hits	17
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK10_MOUSE
NC score	-0.000912 (rank : 134)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	115	Target Neighborhood Hits	2132	Shared Neighborhood Hits	22
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

OLF9_MOUSE
NC score	-0.001635 (rank : 135)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	115	Target Neighborhood Hits	700	Shared Neighborhood Hits	9
SwissProt Accessions	Q60885, Q8VGC0	Gene names	Olfr9, Mor269-3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 9 (Olfactory receptor 269-3) (Odorant receptor M25).

TMPS6_HUMAN
NC score	-0.002268 (rank : 136)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	115	Target Neighborhood Hits	338	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IU80, Q5TI06, Q6UXD8, Q8IUE2, Q8IXV8	Gene names	TMPRSS6
Domain Architecture
Description	Transmembrane protease, serine 6 (EC 3.4.21.-) (Matriptase-2).

AIOL_MOUSE
NC score	-0.004259 (rank : 137)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	115	Target Neighborhood Hits	759	Shared Neighborhood Hits	4
SwissProt Accessions	O08900	Gene names	Ikzf3, Zfpn1a3, Znfn1a3
Domain Architecture	No domain graphic available
Description	Zinc finger protein Aiolos (IKAROS family zinc finger protein 3).