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Network neighborhood for query Sequence : SCN5A_HUMAN

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SCN5A_HUMAN
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SC10A_HUMAN
θ value	0 (rank : 1)	NC score	0.992667 (rank : 3)
Query Neighborhood Hits	145	Target Neighborhood Hits	116	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
θ value	0 (rank : 2)	NC score	0.993165 (rank : 2)
Query Neighborhood Hits	145	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC11A_HUMAN
θ value	0 (rank : 3)	NC score	0.986495 (rank : 8)
Query Neighborhood Hits	145	Target Neighborhood Hits	111	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC11A_MOUSE
θ value	0 (rank : 4)	NC score	0.988058 (rank : 5)
Query Neighborhood Hits	145	Target Neighborhood Hits	116	Shared Neighborhood Hits	71
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN1A_HUMAN
θ value	0 (rank : 5)	NC score	0.986532 (rank : 7)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0 (rank : 6)	NC score	0.985924 (rank : 10)
Query Neighborhood Hits	145	Target Neighborhood Hits	157	Shared Neighborhood Hits	68
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
θ value	0 (rank : 7)	NC score	0.988193 (rank : 4)
Query Neighborhood Hits	145	Target Neighborhood Hits	115	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
θ value	0 (rank : 8)	NC score	0.987745 (rank : 6)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	74
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN5A_HUMAN
θ value	0 (rank : 9)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	145	Target Neighborhood Hits	145	Shared Neighborhood Hits	145
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SCN7A_HUMAN
θ value	0 (rank : 10)	NC score	0.978532 (rank : 13)
Query Neighborhood Hits	145	Target Neighborhood Hits	135	Shared Neighborhood Hits	54
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN8A_HUMAN
θ value	0 (rank : 11)	NC score	0.986249 (rank : 9)
Query Neighborhood Hits	145	Target Neighborhood Hits	135	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	0 (rank : 12)	NC score	0.985600 (rank : 12)
Query Neighborhood Hits	145	Target Neighborhood Hits	136	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN9A_HUMAN
θ value	0 (rank : 13)	NC score	0.985736 (rank : 11)
Query Neighborhood Hits	145	Target Neighborhood Hits	157	Shared Neighborhood Hits	76
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

CAC1A_MOUSE
θ value	3.70236e-70 (rank : 14)	NC score	0.862568 (rank : 19)
Query Neighborhood Hits	145	Target Neighborhood Hits	267	Shared Neighborhood Hits	63
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1D_HUMAN
θ value	1.83746e-69 (rank : 15)	NC score	0.857788 (rank : 22)
Query Neighborhood Hits	145	Target Neighborhood Hits	118	Shared Neighborhood Hits	60
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1A_HUMAN
θ value	1.19101e-68 (rank : 16)	NC score	0.855339 (rank : 25)
Query Neighborhood Hits	145	Target Neighborhood Hits	387	Shared Neighborhood Hits	67
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1S_MOUSE
θ value	4.52582e-68 (rank : 17)	NC score	0.858206 (rank : 21)
Query Neighborhood Hits	145	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1I_HUMAN
θ value	5.91091e-68 (rank : 18)	NC score	0.901370 (rank : 14)
Query Neighborhood Hits	145	Target Neighborhood Hits	138	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1B_MOUSE
θ value	1.00825e-67 (rank : 19)	NC score	0.853561 (rank : 26)
Query Neighborhood Hits	145	Target Neighborhood Hits	351	Shared Neighborhood Hits	59
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_HUMAN
θ value	2.93355e-67 (rank : 20)	NC score	0.857126 (rank : 23)
Query Neighborhood Hits	145	Target Neighborhood Hits	92	Shared Neighborhood Hits	56
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1E_HUMAN
θ value	7.2256e-66 (rank : 21)	NC score	0.866894 (rank : 18)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	1.2325e-65 (rank : 22)	NC score	0.867231 (rank : 17)
Query Neighborhood Hits	145	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1C_MOUSE
θ value	2.74572e-65 (rank : 23)	NC score	0.850197 (rank : 29)
Query Neighborhood Hits	145	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1F_MOUSE
θ value	6.11685e-65 (rank : 24)	NC score	0.853498 (rank : 27)
Query Neighborhood Hits	145	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1H_MOUSE
θ value	3.96481e-64 (rank : 25)	NC score	0.880581 (rank : 15)
Query Neighborhood Hits	145	Target Neighborhood Hits	230	Shared Neighborhood Hits	63
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
θ value	5.17823e-64 (rank : 26)	NC score	0.873663 (rank : 16)
Query Neighborhood Hits	145	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1F_HUMAN
θ value	6.76295e-64 (rank : 27)	NC score	0.852519 (rank : 28)
Query Neighborhood Hits	145	Target Neighborhood Hits	141	Shared Neighborhood Hits	62
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1G_HUMAN
θ value	1.96772e-63 (rank : 28)	NC score	0.858302 (rank : 20)
Query Neighborhood Hits	145	Target Neighborhood Hits	587	Shared Neighborhood Hits	69
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1B_HUMAN
θ value	5.7252e-63 (rank : 29)	NC score	0.856883 (rank : 24)
Query Neighborhood Hits	145	Target Neighborhood Hits	257	Shared Neighborhood Hits	59
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1C_HUMAN
θ value	2.48917e-58 (rank : 30)	NC score	0.845448 (rank : 30)
Query Neighborhood Hits	145	Target Neighborhood Hits	158	Shared Neighborhood Hits	59
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PKD2_MOUSE
θ value	6.43352e-06 (rank : 31)	NC score	0.296645 (rank : 33)
Query Neighborhood Hits	145	Target Neighborhood Hits	99	Shared Neighborhood Hits	45
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

KCNS2_MOUSE
θ value	2.44474e-05 (rank : 32)	NC score	0.213394 (rank : 39)
Query Neighborhood Hits	145	Target Neighborhood Hits	130	Shared Neighborhood Hits	53
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
θ value	5.44631e-05 (rank : 33)	NC score	0.208099 (rank : 40)
Query Neighborhood Hits	145	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS3_HUMAN
θ value	5.44631e-05 (rank : 34)	NC score	0.181178 (rank : 43)
Query Neighborhood Hits	145	Target Neighborhood Hits	125	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

PKD2_HUMAN
θ value	9.29e-05 (rank : 35)	NC score	0.290354 (rank : 35)
Query Neighborhood Hits	145	Target Neighborhood Hits	105	Shared Neighborhood Hits	43
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PK2L1_HUMAN
θ value	0.00035302 (rank : 36)	NC score	0.309196 (rank : 32)
Query Neighborhood Hits	145	Target Neighborhood Hits	132	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

KCNF1_HUMAN
θ value	0.000461057 (rank : 37)	NC score	0.233566 (rank : 36)
Query Neighborhood Hits	145	Target Neighborhood Hits	109	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

PK2L2_HUMAN
θ value	0.000461057 (rank : 38)	NC score	0.330244 (rank : 31)
Query Neighborhood Hits	145	Target Neighborhood Hits	90	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKDRE_HUMAN
θ value	0.000602161 (rank : 39)	NC score	0.148035 (rank : 50)
Query Neighborhood Hits	145	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNB2_HUMAN
θ value	0.00102713 (rank : 40)	NC score	0.215547 (rank : 38)
Query Neighborhood Hits	145	Target Neighborhood Hits	212	Shared Neighborhood Hits	56
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

PKDRE_MOUSE
θ value	0.00175202 (rank : 41)	NC score	0.120938 (rank : 59)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNV2_HUMAN
θ value	0.00298849 (rank : 42)	NC score	0.218912 (rank : 37)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNS1_HUMAN
θ value	0.0113563 (rank : 43)	NC score	0.145661 (rank : 52)
Query Neighborhood Hits	145	Target Neighborhood Hits	116	Shared Neighborhood Hits	51
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

RERE_MOUSE
θ value	0.0148317 (rank : 44)	NC score	0.025593 (rank : 96)
Query Neighborhood Hits	145	Target Neighborhood Hits	785	Shared Neighborhood Hits	19
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

KCNB1_HUMAN
θ value	0.0193708 (rank : 45)	NC score	0.195660 (rank : 41)
Query Neighborhood Hits	145	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	0.0193708 (rank : 46)	NC score	0.195633 (rank : 42)
Query Neighborhood Hits	145	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KI13B_HUMAN
θ value	0.0252991 (rank : 47)	NC score	0.007173 (rank : 123)
Query Neighborhood Hits	145	Target Neighborhood Hits	492	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

KCNC1_HUMAN
θ value	0.0431538 (rank : 48)	NC score	0.146784 (rank : 51)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	48
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
θ value	0.0563607 (rank : 49)	NC score	0.144504 (rank : 53)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	48
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCND3_HUMAN
θ value	0.0563607 (rank : 50)	NC score	0.175794 (rank : 45)
Query Neighborhood Hits	145	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.0563607 (rank : 51)	NC score	0.175931 (rank : 44)
Query Neighborhood Hits	145	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

TARA_HUMAN
θ value	0.0563607 (rank : 52)	NC score	0.024922 (rank : 97)
Query Neighborhood Hits	145	Target Neighborhood Hits	1626	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TRPC1_HUMAN
θ value	0.0563607 (rank : 53)	NC score	0.070624 (rank : 78)
Query Neighborhood Hits	145	Target Neighborhood Hits	91	Shared Neighborhood Hits	22
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	0.0563607 (rank : 54)	NC score	0.070735 (rank : 77)
Query Neighborhood Hits	145	Target Neighborhood Hits	87	Shared Neighborhood Hits	22
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

KCND2_HUMAN
θ value	0.0736092 (rank : 55)	NC score	0.168692 (rank : 47)
Query Neighborhood Hits	145	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.0736092 (rank : 56)	NC score	0.168869 (rank : 46)
Query Neighborhood Hits	145	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

CAD16_HUMAN
θ value	0.125558 (rank : 57)	NC score	0.005179 (rank : 132)
Query Neighborhood Hits	145	Target Neighborhood Hits	159	Shared Neighborhood Hits	3
SwissProt Accessions	O75309, Q6UW93	Gene names	CDH16
Domain Architecture
Description	Cadherin-16 precursor (Kidney-specific cadherin) (Ksp-cadherin).

PK2L2_MOUSE
θ value	0.125558 (rank : 58)	NC score	0.293199 (rank : 34)
Query Neighborhood Hits	145	Target Neighborhood Hits	84	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

TRPV3_HUMAN
θ value	0.125558 (rank : 59)	NC score	0.100556 (rank : 61)
Query Neighborhood Hits	145	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV4_MOUSE
θ value	0.163984 (rank : 60)	NC score	0.071343 (rank : 76)
Query Neighborhood Hits	145	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

AKAP8_HUMAN
θ value	0.21417 (rank : 61)	NC score	0.016414 (rank : 106)
Query Neighborhood Hits	145	Target Neighborhood Hits	166	Shared Neighborhood Hits	5
SwissProt Accessions	O43823	Gene names	AKAP8, AKAP95
Domain Architecture
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

KCNC3_HUMAN
θ value	0.21417 (rank : 62)	NC score	0.121534 (rank : 58)
Query Neighborhood Hits	145	Target Neighborhood Hits	256	Shared Neighborhood Hits	50
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
θ value	0.279714 (rank : 63)	NC score	0.119350 (rank : 60)
Query Neighborhood Hits	145	Target Neighborhood Hits	173	Shared Neighborhood Hits	49
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC4_HUMAN
θ value	0.279714 (rank : 64)	NC score	0.128361 (rank : 55)
Query Neighborhood Hits	145	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
θ value	0.279714 (rank : 65)	NC score	0.121539 (rank : 57)
Query Neighborhood Hits	145	Target Neighborhood Hits	130	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

MKL1_MOUSE
θ value	0.279714 (rank : 66)	NC score	0.016044 (rank : 107)
Query Neighborhood Hits	145	Target Neighborhood Hits	667	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

TRPV4_HUMAN
θ value	0.279714 (rank : 67)	NC score	0.069531 (rank : 80)
Query Neighborhood Hits	145	Target Neighborhood Hits	150	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

CABP5_MOUSE
θ value	0.365318 (rank : 68)	NC score	0.054684 (rank : 89)
Query Neighborhood Hits	145	Target Neighborhood Hits	207	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

TFE2_HUMAN
θ value	0.365318 (rank : 69)	NC score	0.011662 (rank : 114)
Query Neighborhood Hits	145	Target Neighborhood Hits	161	Shared Neighborhood Hits	2
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

TPTE2_HUMAN
θ value	0.365318 (rank : 70)	NC score	0.140357 (rank : 54)
Query Neighborhood Hits	145	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

TGON2_HUMAN
θ value	0.47712 (rank : 71)	NC score	0.022645 (rank : 99)
Query Neighborhood Hits	145	Target Neighborhood Hits	1037	Shared Neighborhood Hits	28
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TRPV3_MOUSE
θ value	0.47712 (rank : 72)	NC score	0.072703 (rank : 73)
Query Neighborhood Hits	145	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

BSCL2_HUMAN
θ value	0.62314 (rank : 73)	NC score	0.024247 (rank : 98)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	9
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

DREB_HUMAN
θ value	0.62314 (rank : 74)	NC score	0.012125 (rank : 110)
Query Neighborhood Hits	145	Target Neighborhood Hits	450	Shared Neighborhood Hits	13
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

MUC5B_HUMAN
θ value	0.62314 (rank : 75)	NC score	0.006437 (rank : 126)
Query Neighborhood Hits	145	Target Neighborhood Hits	1020	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

PCLO_HUMAN
θ value	0.62314 (rank : 76)	NC score	0.011959 (rank : 112)
Query Neighborhood Hits	145	Target Neighborhood Hits	2046	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

BAT2_MOUSE
θ value	0.813845 (rank : 77)	NC score	0.020448 (rank : 100)
Query Neighborhood Hits	145	Target Neighborhood Hits	947	Shared Neighborhood Hits	24
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

KCND1_MOUSE
θ value	0.813845 (rank : 78)	NC score	0.150476 (rank : 48)
Query Neighborhood Hits	145	Target Neighborhood Hits	165	Shared Neighborhood Hits	52
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

AMPH_MOUSE
θ value	1.06291 (rank : 79)	NC score	0.011767 (rank : 113)
Query Neighborhood Hits	145	Target Neighborhood Hits	291	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

KCND1_HUMAN
θ value	1.06291 (rank : 80)	NC score	0.148746 (rank : 49)
Query Neighborhood Hits	145	Target Neighborhood Hits	160	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

MAP1A_HUMAN
θ value	1.06291 (rank : 81)	NC score	0.008506 (rank : 121)
Query Neighborhood Hits	145	Target Neighborhood Hits	1626	Shared Neighborhood Hits	29
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

OX2R_HUMAN
θ value	1.06291 (rank : 82)	NC score	-0.000861 (rank : 160)
Query Neighborhood Hits	145	Target Neighborhood Hits	929	Shared Neighborhood Hits	6
SwissProt Accessions	O43614	Gene names	HCRTR2
Domain Architecture
Description	Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2).

OX2R_MOUSE
θ value	1.06291 (rank : 83)	NC score	-0.000870 (rank : 161)
Query Neighborhood Hits	145	Target Neighborhood Hits	921	Shared Neighborhood Hits	6
SwissProt Accessions	P58308, Q5SGC8, Q6VLX3, Q8BG12	Gene names	Hcrtr2, Mox2r
Domain Architecture
Description	Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2).

DNMT1_MOUSE
θ value	1.38821 (rank : 84)	NC score	0.013509 (rank : 108)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

HRH1_HUMAN
θ value	1.81305 (rank : 85)	NC score	-0.000102 (rank : 156)
Query Neighborhood Hits	145	Target Neighborhood Hits	916	Shared Neighborhood Hits	7
SwissProt Accessions	P35367	Gene names	HRH1
Domain Architecture
Description	Histamine H1 receptor.

CGRE1_MOUSE
θ value	2.36792 (rank : 86)	NC score	0.017162 (rank : 105)
Query Neighborhood Hits	145	Target Neighborhood Hits	173	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R1U2, Q9D1K1	Gene names	Cgref1, Cgr11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

EP400_HUMAN
θ value	2.36792 (rank : 87)	NC score	0.005056 (rank : 133)
Query Neighborhood Hits	145	Target Neighborhood Hits	556	Shared Neighborhood Hits	14
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

HAIR_HUMAN
θ value	2.36792 (rank : 88)	NC score	0.007688 (rank : 122)
Query Neighborhood Hits	145	Target Neighborhood Hits	172	Shared Neighborhood Hits	6
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

IWS1_MOUSE
θ value	2.36792 (rank : 89)	NC score	0.027977 (rank : 95)
Query Neighborhood Hits	145	Target Neighborhood Hits	1258	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LYRIC_MOUSE
θ value	2.36792 (rank : 90)	NC score	0.010768 (rank : 115)
Query Neighborhood Hits	145	Target Neighborhood Hits	126	Shared Neighborhood Hits	5
SwissProt Accessions	Q80WJ7, Q3U9F8, Q3UAQ8, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052	Gene names	Mtdh, Lyric
Domain Architecture	No domain graphic available
Description	Protein LYRIC (Lysine-rich CEACAM1 co-isolated protein) (3D3/LYRIC) (Metastasis adhesion protein) (Metadherin).

NRIP1_MOUSE
θ value	2.36792 (rank : 91)	NC score	0.009876 (rank : 117)
Query Neighborhood Hits	145	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CBD1, Q8C3Y8, Q9Z2K2	Gene names	Nrip1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

OSBP2_HUMAN
θ value	2.36792 (rank : 92)	NC score	0.006160 (rank : 128)
Query Neighborhood Hits	145	Target Neighborhood Hits	154	Shared Neighborhood Hits	10
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

AP3B1_MOUSE
θ value	3.0926 (rank : 93)	NC score	0.005388 (rank : 131)
Query Neighborhood Hits	145	Target Neighborhood Hits	302	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

FBX7_HUMAN
θ value	3.0926 (rank : 94)	NC score	0.013246 (rank : 109)
Query Neighborhood Hits	145	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3I1, Q5TGC4, Q96HM6, Q9UF21, Q9UKT2	Gene names	FBXO7, FBX7
Domain Architecture	No domain graphic available
Description	F-box only protein 7.

KCNS1_MOUSE
θ value	3.0926 (rank : 95)	NC score	0.127322 (rank : 56)
Query Neighborhood Hits	145	Target Neighborhood Hits	114	Shared Neighborhood Hits	45
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

NCBP1_HUMAN
θ value	3.0926 (rank : 96)	NC score	0.009328 (rank : 119)
Query Neighborhood Hits	145	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q09161, Q59G76, Q5T1V0	Gene names	NCBP1, CBP80, NCBP
Domain Architecture
Description	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (NCBP 80 kDa subunit) (CBP80).

NELF_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.017264 (rank : 104)
Query Neighborhood Hits	145	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q6X4W1, Q6X4V7, Q6X4V8, Q6X4V9, Q8N2M2, Q96SY1, Q9NPM4, Q9NPP3, Q9NPS3	Gene names	NELF
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor).

NELF_MOUSE
θ value	3.0926 (rank : 98)	NC score	0.019234 (rank : 101)
Query Neighborhood Hits	145	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q99NF2, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1	Gene names	Nelf, Jac
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor) (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein).

RERE_HUMAN
θ value	3.0926 (rank : 99)	NC score	0.017938 (rank : 102)
Query Neighborhood Hits	145	Target Neighborhood Hits	779	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

TCO1_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.010437 (rank : 116)
Query Neighborhood Hits	145	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P20061, Q8WV77	Gene names	TCN1, TC1
Domain Architecture
Description	Transcobalamin-1 precursor (Transcobalamin I) (TCI) (TC I).

GLGB_MOUSE
θ value	4.03905 (rank : 101)	NC score	0.008566 (rank : 120)
Query Neighborhood Hits	145	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D6Y9	Gene names	Gbe1
Domain Architecture	No domain graphic available
Description	1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (Glycogen branching enzyme) (Brancher enzyme).

MDC1_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.006461 (rank : 125)
Query Neighborhood Hits	145	Target Neighborhood Hits	1446	Shared Neighborhood Hits	26
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MY18B_HUMAN
θ value	4.03905 (rank : 103)	NC score	-0.000688 (rank : 157)
Query Neighborhood Hits	145	Target Neighborhood Hits	1299	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

OBSCN_HUMAN
θ value	4.03905 (rank : 104)	NC score	-0.004837 (rank : 165)
Query Neighborhood Hits	145	Target Neighborhood Hits	1931	Shared Neighborhood Hits	22
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PTN22_MOUSE
θ value	4.03905 (rank : 105)	NC score	0.001710 (rank : 145)
Query Neighborhood Hits	145	Target Neighborhood Hits	179	Shared Neighborhood Hits	5
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

RN168_HUMAN
θ value	4.03905 (rank : 106)	NC score	0.003829 (rank : 138)
Query Neighborhood Hits	145	Target Neighborhood Hits	370	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TPTE_HUMAN
θ value	4.03905 (rank : 107)	NC score	0.095420 (rank : 62)
Query Neighborhood Hits	145	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

TXLNB_HUMAN
θ value	4.03905 (rank : 108)	NC score	0.003026 (rank : 141)
Query Neighborhood Hits	145	Target Neighborhood Hits	912	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

ADA11_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.000349 (rank : 154)
Query Neighborhood Hits	145	Target Neighborhood Hits	259	Shared Neighborhood Hits	3
SwissProt Accessions	O75078, Q14808, Q14809, Q14810	Gene names	ADAM11, MDC
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

CABP5_HUMAN
θ value	5.27518 (rank : 110)	NC score	0.037672 (rank : 93)
Query Neighborhood Hits	145	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

ESR1_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.000400 (rank : 152)
Query Neighborhood Hits	145	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

OLF9_MOUSE
θ value	5.27518 (rank : 112)	NC score	-0.001713 (rank : 163)
Query Neighborhood Hits	145	Target Neighborhood Hits	700	Shared Neighborhood Hits	12
SwissProt Accessions	Q60885, Q8VGC0	Gene names	Olfr9, Mor269-3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 9 (Olfactory receptor 269-3) (Odorant receptor M25).

PSL1_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.004892 (rank : 134)
Query Neighborhood Hits	145	Target Neighborhood Hits	650	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

TACC1_MOUSE
θ value	5.27518 (rank : 114)	NC score	0.002548 (rank : 143)
Query Neighborhood Hits	145	Target Neighborhood Hits	667	Shared Neighborhood Hits	12
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TRPC4_HUMAN
θ value	5.27518 (rank : 115)	NC score	0.045170 (rank : 91)
Query Neighborhood Hits	145	Target Neighborhood Hits	140	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPV5_HUMAN
θ value	5.27518 (rank : 116)	NC score	0.017372 (rank : 103)
Query Neighborhood Hits	145	Target Neighborhood Hits	261	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

ABCA9_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.000592 (rank : 151)
Query Neighborhood Hits	145	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IUA7, Q6P655, Q8N2S4, Q8WWZ5, Q96MD8	Gene names	ABCA9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

CILP2_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.001982 (rank : 144)
Query Neighborhood Hits	145	Target Neighborhood Hits	307	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CUBN_MOUSE
θ value	6.88961 (rank : 119)	NC score	-0.001782 (rank : 164)
Query Neighborhood Hits	145	Target Neighborhood Hits	477	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

DLX1_HUMAN
θ value	6.88961 (rank : 120)	NC score	-0.000716 (rank : 158)
Query Neighborhood Hits	145	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	P56177, Q53ZU4, Q8IYB2	Gene names	DLX1
Domain Architecture
Description	Homeobox protein DLX-1.

DLX1_MOUSE
θ value	6.88961 (rank : 121)	NC score	-0.000717 (rank : 159)
Query Neighborhood Hits	145	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	Q64317	Gene names	Dlx1
Domain Architecture
Description	Homeobox protein DLX-1.

EDD1_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.003145 (rank : 140)
Query Neighborhood Hits	145	Target Neighborhood Hits	170	Shared Neighborhood Hits	5
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

TB182_HUMAN
θ value	6.88961 (rank : 123)	NC score	0.009775 (rank : 118)
Query Neighborhood Hits	145	Target Neighborhood Hits	414	Shared Neighborhood Hits	14
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TRPC4_MOUSE
θ value	6.88961 (rank : 124)	NC score	0.044232 (rank : 92)
Query Neighborhood Hits	145	Target Neighborhood Hits	141	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPV1_HUMAN
θ value	6.88961 (rank : 125)	NC score	0.046264 (rank : 90)
Query Neighborhood Hits	145	Target Neighborhood Hits	184	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	6.88961 (rank : 126)	NC score	0.035349 (rank : 94)
Query Neighborhood Hits	145	Target Neighborhood Hits	189	Shared Neighborhood Hits	18
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

ARHG1_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.001161 (rank : 148)
Query Neighborhood Hits	145	Target Neighborhood Hits	176	Shared Neighborhood Hits	3
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

CI061_MOUSE
θ value	8.99809 (rank : 128)	NC score	0.006201 (rank : 127)
Query Neighborhood Hits	145	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q4FZH1	Gene names	Gm967
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf61 homolog.

CSTFT_MOUSE
θ value	8.99809 (rank : 129)	NC score	0.006057 (rank : 129)
Query Neighborhood Hits	145	Target Neighborhood Hits	356	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

EPHB3_MOUSE
θ value	8.99809 (rank : 130)	NC score	-0.005286 (rank : 166)
Query Neighborhood Hits	145	Target Neighborhood Hits	996	Shared Neighborhood Hits	3
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

FA26B_MOUSE
θ value	8.99809 (rank : 131)	NC score	0.003878 (rank : 137)
Query Neighborhood Hits	145	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEC4, Q3TDQ7, Q8BT85, Q8C246	Gene names	Fam26b
Domain Architecture	No domain graphic available
Description	Protein FAM26B.

FANCG_MOUSE
θ value	8.99809 (rank : 132)	NC score	0.005411 (rank : 130)
Query Neighborhood Hits	145	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EQR6	Gene names	Fancg
Domain Architecture	No domain graphic available
Description	Fanconi anemia group G protein homolog (Protein FACG).

FCRLA_MOUSE
θ value	8.99809 (rank : 133)	NC score	0.002663 (rank : 142)
Query Neighborhood Hits	145	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

HXC10_HUMAN
θ value	8.99809 (rank : 134)	NC score	-0.001444 (rank : 162)
Query Neighborhood Hits	145	Target Neighborhood Hits	417	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

LBXCO_MOUSE
θ value	8.99809 (rank : 135)	NC score	0.003419 (rank : 139)
Query Neighborhood Hits	145	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

MPP5_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.001183 (rank : 147)
Query Neighborhood Hits	145	Target Neighborhood Hits	231	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

MPP5_MOUSE
θ value	8.99809 (rank : 137)	NC score	0.001196 (rank : 146)
Query Neighborhood Hits	145	Target Neighborhood Hits	226	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

PHOS_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.004192 (rank : 136)
Query Neighborhood Hits	145	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P20941, Q14816	Gene names	PDC
Domain Architecture
Description	Phosducin (PHD) (33 kDa phototransducing protein) (MEKA protein).

PIGN_MOUSE
θ value	8.99809 (rank : 139)	NC score	0.004571 (rank : 135)
Query Neighborhood Hits	145	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1S3, Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2	Gene names	Pign
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N).

RGS12_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.000963 (rank : 150)
Query Neighborhood Hits	145	Target Neighborhood Hits	333	Shared Neighborhood Hits	9
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

SC6A5_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.000398 (rank : 153)
Query Neighborhood Hits	145	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y345, O95288, Q9BX77	Gene names	SLC6A5, GLYT2
Domain Architecture
Description	Sodium- and chloride-dependent glycine transporter 2 (GlyT2) (GlyT-2) (Solute carrier family 6 member 5).

SYN3_MOUSE
θ value	8.99809 (rank : 142)	NC score	0.006572 (rank : 124)
Query Neighborhood Hits	145	Target Neighborhood Hits	200	Shared Neighborhood Hits	11
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

T2FA_HUMAN
θ value	8.99809 (rank : 143)	NC score	0.011986 (rank : 111)
Query Neighborhood Hits	145	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

TBX19_HUMAN
θ value	8.99809 (rank : 144)	NC score	0.001041 (rank : 149)
Query Neighborhood Hits	145	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	O60806	Gene names	TBX19, TPIT
Domain Architecture
Description	T-box transcription factor TBX19 (T-box protein 19) (T-box factor, pituitary).

UBP8_MOUSE
θ value	8.99809 (rank : 145)	NC score	0.000317 (rank : 155)
Query Neighborhood Hits	145	Target Neighborhood Hits	362	Shared Neighborhood Hits	10
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

KCNA1_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.080665 (rank : 66)
Query Neighborhood Hits	145	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA1_MOUSE
θ value	θ > 10 (rank : 147)	NC score	0.082063 (rank : 65)
Query Neighborhood Hits	145	Target Neighborhood Hits	103	Shared Neighborhood Hits	36
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA2_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.078650 (rank : 68)
Query Neighborhood Hits	145	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA2_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.079498 (rank : 67)
Query Neighborhood Hits	145	Target Neighborhood Hits	102	Shared Neighborhood Hits	33
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA3_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.071511 (rank : 75)
Query Neighborhood Hits	145	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.070537 (rank : 79)
Query Neighborhood Hits	145	Target Neighborhood Hits	103	Shared Neighborhood Hits	29
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA4_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.057410 (rank : 87)
Query Neighborhood Hits	145	Target Neighborhood Hits	108	Shared Neighborhood Hits	24
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.057770 (rank : 86)
Query Neighborhood Hits	145	Target Neighborhood Hits	98	Shared Neighborhood Hits	24
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA5_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.067777 (rank : 81)
Query Neighborhood Hits	145	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.072918 (rank : 72)
Query Neighborhood Hits	145	Target Neighborhood Hits	119	Shared Neighborhood Hits	33
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA6_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.073933 (rank : 71)
Query Neighborhood Hits	145	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA6_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.076684 (rank : 70)
Query Neighborhood Hits	145	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.071880 (rank : 74)
Query Neighborhood Hits	145	Target Neighborhood Hits	103	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNG2_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.065711 (rank : 83)
Query Neighborhood Hits	145	Target Neighborhood Hits	83	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG3_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.094516 (rank : 64)
Query Neighborhood Hits	145	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.094600 (rank : 63)
Query Neighborhood Hits	145	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG4_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.064521 (rank : 84)
Query Neighborhood Hits	145	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.059465 (rank : 85)
Query Neighborhood Hits	145	Target Neighborhood Hits	99	Shared Neighborhood Hits	31
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ1_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.067488 (rank : 82)
Query Neighborhood Hits	145	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ4_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.077262 (rank : 69)
Query Neighborhood Hits	145	Target Neighborhood Hits	136	Shared Neighborhood Hits	34
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNQ5_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.055948 (rank : 88)
Query Neighborhood Hits	145	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

Hits sorted by NC score

SCN5A_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 9)
Query Neighborhood Hits	145	Target Neighborhood Hits	145	Shared Neighborhood Hits	145
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SC10A_MOUSE
NC score	0.993165 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	145	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SC10A_HUMAN
NC score	0.992667 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	145	Target Neighborhood Hits	116	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN3A_HUMAN
NC score	0.988193 (rank : 4)	θ value	0 (rank : 7)
Query Neighborhood Hits	145	Target Neighborhood Hits	115	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SC11A_MOUSE
NC score	0.988058 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	145	Target Neighborhood Hits	116	Shared Neighborhood Hits	71
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN4A_HUMAN
NC score	0.987745 (rank : 6)	θ value	0 (rank : 8)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	74
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN1A_HUMAN
NC score	0.986532 (rank : 7)	θ value	0 (rank : 5)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SC11A_HUMAN
NC score	0.986495 (rank : 8)	θ value	0 (rank : 3)
Query Neighborhood Hits	145	Target Neighborhood Hits	111	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN8A_HUMAN
NC score	0.986249 (rank : 9)	θ value	0 (rank : 11)
Query Neighborhood Hits	145	Target Neighborhood Hits	135	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN2A_HUMAN
NC score	0.985924 (rank : 10)	θ value	0 (rank : 6)
Query Neighborhood Hits	145	Target Neighborhood Hits	157	Shared Neighborhood Hits	68
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN9A_HUMAN
NC score	0.985736 (rank : 11)	θ value	0 (rank : 13)
Query Neighborhood Hits	145	Target Neighborhood Hits	157	Shared Neighborhood Hits	76
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN8A_MOUSE
NC score	0.985600 (rank : 12)	θ value	0 (rank : 12)
Query Neighborhood Hits	145	Target Neighborhood Hits	136	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN7A_HUMAN
NC score	0.978532 (rank : 13)	θ value	0 (rank : 10)
Query Neighborhood Hits	145	Target Neighborhood Hits	135	Shared Neighborhood Hits	54
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

CAC1I_HUMAN
NC score	0.901370 (rank : 14)	θ value	5.91091e-68 (rank : 18)
Query Neighborhood Hits	145	Target Neighborhood Hits	138	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.880581 (rank : 15)	θ value	3.96481e-64 (rank : 25)
Query Neighborhood Hits	145	Target Neighborhood Hits	230	Shared Neighborhood Hits	63
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.873663 (rank : 16)	θ value	5.17823e-64 (rank : 26)
Query Neighborhood Hits	145	Target Neighborhood Hits	307	Shared Neighborhood Hits	67
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1E_MOUSE
NC score	0.867231 (rank : 17)	θ value	1.2325e-65 (rank : 22)
Query Neighborhood Hits	145	Target Neighborhood Hits	167	Shared Neighborhood Hits	62
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.866894 (rank : 18)	θ value	7.2256e-66 (rank : 21)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	62
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1A_MOUSE
NC score	0.862568 (rank : 19)	θ value	3.70236e-70 (rank : 14)
Query Neighborhood Hits	145	Target Neighborhood Hits	267	Shared Neighborhood Hits	63
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1G_HUMAN
NC score	0.858302 (rank : 20)	θ value	1.96772e-63 (rank : 28)
Query Neighborhood Hits	145	Target Neighborhood Hits	587	Shared Neighborhood Hits	69
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1S_MOUSE
NC score	0.858206 (rank : 21)	θ value	4.52582e-68 (rank : 17)
Query Neighborhood Hits	145	Target Neighborhood Hits	98	Shared Neighborhood Hits	58
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1D_HUMAN
NC score	0.857788 (rank : 22)	θ value	1.83746e-69 (rank : 15)
Query Neighborhood Hits	145	Target Neighborhood Hits	118	Shared Neighborhood Hits	60
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1S_HUMAN
NC score	0.857126 (rank : 23)	θ value	2.93355e-67 (rank : 20)
Query Neighborhood Hits	145	Target Neighborhood Hits	92	Shared Neighborhood Hits	56
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_HUMAN
NC score	0.856883 (rank : 24)	θ value	5.7252e-63 (rank : 29)
Query Neighborhood Hits	145	Target Neighborhood Hits	257	Shared Neighborhood Hits	59
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_HUMAN
NC score	0.855339 (rank : 25)	θ value	1.19101e-68 (rank : 16)
Query Neighborhood Hits	145	Target Neighborhood Hits	387	Shared Neighborhood Hits	67
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
NC score	0.853561 (rank : 26)	θ value	1.00825e-67 (rank : 19)
Query Neighborhood Hits	145	Target Neighborhood Hits	351	Shared Neighborhood Hits	59
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_MOUSE
NC score	0.853498 (rank : 27)	θ value	6.11685e-65 (rank : 24)
Query Neighborhood Hits	145	Target Neighborhood Hits	142	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.852519 (rank : 28)	θ value	6.76295e-64 (rank : 27)
Query Neighborhood Hits	145	Target Neighborhood Hits	141	Shared Neighborhood Hits	62
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.850197 (rank : 29)	θ value	2.74572e-65 (rank : 23)
Query Neighborhood Hits	145	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.845448 (rank : 30)	θ value	2.48917e-58 (rank : 30)
Query Neighborhood Hits	145	Target Neighborhood Hits	158	Shared Neighborhood Hits	59
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

PK2L2_HUMAN
NC score	0.330244 (rank : 31)	θ value	0.000461057 (rank : 38)
Query Neighborhood Hits	145	Target Neighborhood Hits	90	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.309196 (rank : 32)	θ value	0.00035302 (rank : 36)
Query Neighborhood Hits	145	Target Neighborhood Hits	132	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_MOUSE
NC score	0.296645 (rank : 33)	θ value	6.43352e-06 (rank : 31)
Query Neighborhood Hits	145	Target Neighborhood Hits	99	Shared Neighborhood Hits	45
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PK2L2_MOUSE
NC score	0.293199 (rank : 34)	θ value	0.125558 (rank : 58)
Query Neighborhood Hits	145	Target Neighborhood Hits	84	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_HUMAN
NC score	0.290354 (rank : 35)	θ value	9.29e-05 (rank : 35)
Query Neighborhood Hits	145	Target Neighborhood Hits	105	Shared Neighborhood Hits	43
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNF1_HUMAN
NC score	0.233566 (rank : 36)	θ value	0.000461057 (rank : 37)
Query Neighborhood Hits	145	Target Neighborhood Hits	109	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNV2_HUMAN
NC score	0.218912 (rank : 37)	θ value	0.00298849 (rank : 42)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNB2_HUMAN
NC score	0.215547 (rank : 38)	θ value	0.00102713 (rank : 40)
Query Neighborhood Hits	145	Target Neighborhood Hits	212	Shared Neighborhood Hits	56
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNS2_MOUSE
NC score	0.213394 (rank : 39)	θ value	2.44474e-05 (rank : 32)
Query Neighborhood Hits	145	Target Neighborhood Hits	130	Shared Neighborhood Hits	53
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_HUMAN
NC score	0.208099 (rank : 40)	θ value	5.44631e-05 (rank : 33)
Query Neighborhood Hits	145	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_HUMAN
NC score	0.195660 (rank : 41)	θ value	0.0193708 (rank : 45)
Query Neighborhood Hits	145	Target Neighborhood Hits	169	Shared Neighborhood Hits	53
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
NC score	0.195633 (rank : 42)	θ value	0.0193708 (rank : 46)
Query Neighborhood Hits	145	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNS3_HUMAN
NC score	0.181178 (rank : 43)	θ value	5.44631e-05 (rank : 34)
Query Neighborhood Hits	145	Target Neighborhood Hits	125	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND3_MOUSE
NC score	0.175931 (rank : 44)	θ value	0.0563607 (rank : 51)
Query Neighborhood Hits	145	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.175794 (rank : 45)	θ value	0.0563607 (rank : 50)
Query Neighborhood Hits	145	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND2_MOUSE
NC score	0.168869 (rank : 46)	θ value	0.0736092 (rank : 56)
Query Neighborhood Hits	145	Target Neighborhood Hits	156	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.168692 (rank : 47)	θ value	0.0736092 (rank : 55)
Query Neighborhood Hits	145	Target Neighborhood Hits	154	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.150476 (rank : 48)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	145	Target Neighborhood Hits	165	Shared Neighborhood Hits	52
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.148746 (rank : 49)	θ value	1.06291 (rank : 80)
Query Neighborhood Hits	145	Target Neighborhood Hits	160	Shared Neighborhood Hits	51
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

PKDRE_HUMAN
NC score	0.148035 (rank : 50)	θ value	0.000602161 (rank : 39)
Query Neighborhood Hits	145	Target Neighborhood Hits	64	Shared Neighborhood Hits	26
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNC1_HUMAN
NC score	0.146784 (rank : 51)	θ value	0.0431538 (rank : 48)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	48
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNS1_HUMAN
NC score	0.145661 (rank : 52)	θ value	0.0113563 (rank : 43)
Query Neighborhood Hits	145	Target Neighborhood Hits	116	Shared Neighborhood Hits	51
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC1_MOUSE
NC score	0.144504 (rank : 53)	θ value	0.0563607 (rank : 49)
Query Neighborhood Hits	145	Target Neighborhood Hits	133	Shared Neighborhood Hits	48
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

TPTE2_HUMAN
NC score	0.140357 (rank : 54)	θ value	0.365318 (rank : 70)
Query Neighborhood Hits	145	Target Neighborhood Hits	68	Shared Neighborhood Hits	26
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNC4_HUMAN
NC score	0.128361 (rank : 55)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	145	Target Neighborhood Hits	141	Shared Neighborhood Hits	48
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNS1_MOUSE
NC score	0.127322 (rank : 56)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	145	Target Neighborhood Hits	114	Shared Neighborhood Hits	45
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC4_MOUSE
NC score	0.121539 (rank : 57)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	145	Target Neighborhood Hits	130	Shared Neighborhood Hits	46
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNC3_HUMAN
NC score	0.121534 (rank : 58)	θ value	0.21417 (rank : 62)
Query Neighborhood Hits	145	Target Neighborhood Hits	256	Shared Neighborhood Hits	50
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

PKDRE_MOUSE
NC score	0.120938 (rank : 59)	θ value	0.00175202 (rank : 41)
Query Neighborhood Hits	145	Target Neighborhood Hits	76	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNC3_MOUSE
NC score	0.119350 (rank : 60)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	145	Target Neighborhood Hits	173	Shared Neighborhood Hits	49
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

TRPV3_HUMAN
NC score	0.100556 (rank : 61)	θ value	0.125558 (rank : 59)
Query Neighborhood Hits	145	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TPTE_HUMAN
NC score	0.095420 (rank : 62)	θ value	4.03905 (rank : 107)
Query Neighborhood Hits	145	Target Neighborhood Hits	53	Shared Neighborhood Hits	24
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

KCNG3_MOUSE
NC score	0.094600 (rank : 63)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	145	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_HUMAN
NC score	0.094516 (rank : 64)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	145	Target Neighborhood Hits	91	Shared Neighborhood Hits	38
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNA1_MOUSE
NC score	0.082063 (rank : 65)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	145	Target Neighborhood Hits	103	Shared Neighborhood Hits	36
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA1_HUMAN
NC score	0.080665 (rank : 66)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	145	Target Neighborhood Hits	104	Shared Neighborhood Hits	35
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA2_MOUSE
NC score	0.079498 (rank : 67)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	145	Target Neighborhood Hits	102	Shared Neighborhood Hits	33
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA2_HUMAN
NC score	0.078650 (rank : 68)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	145	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNQ4_HUMAN
NC score	0.077262 (rank : 69)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	145	Target Neighborhood Hits	136	Shared Neighborhood Hits	34
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNA6_MOUSE
NC score	0.076684 (rank : 70)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	145	Target Neighborhood Hits	106	Shared Neighborhood Hits	36
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNA6_HUMAN
NC score	0.073933 (rank : 71)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	145	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA5_MOUSE
NC score	0.072918 (rank : 72)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	145	Target Neighborhood Hits	119	Shared Neighborhood Hits	33
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

TRPV3_MOUSE
NC score	0.072703 (rank : 73)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	145	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

KCNG1_HUMAN
NC score	0.071880 (rank : 74)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	145	Target Neighborhood Hits	103	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNA3_HUMAN
NC score	0.071511 (rank : 75)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	145	Target Neighborhood Hits	101	Shared Neighborhood Hits	31
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

TRPV4_MOUSE
NC score	0.071343 (rank : 76)	θ value	0.163984 (rank : 60)
Query Neighborhood Hits	145	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPC1_MOUSE
NC score	0.070735 (rank : 77)	θ value	0.0563607 (rank : 54)
Query Neighborhood Hits	145	Target Neighborhood Hits	87	Shared Neighborhood Hits	22
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.070624 (rank : 78)	θ value	0.0563607 (rank : 53)
Query Neighborhood Hits	145	Target Neighborhood Hits	91	Shared Neighborhood Hits	22
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

KCNA3_MOUSE
NC score	0.070537 (rank : 79)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	145	Target Neighborhood Hits	103	Shared Neighborhood Hits	29
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

TRPV4_HUMAN
NC score	0.069531 (rank : 80)	θ value	0.279714 (rank : 67)
Query Neighborhood Hits	145	Target Neighborhood Hits	150	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

KCNA5_HUMAN
NC score	0.067777 (rank : 81)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	145	Target Neighborhood Hits	124	Shared Neighborhood Hits	29
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNQ1_MOUSE
NC score	0.067488 (rank : 82)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	145	Target Neighborhood Hits	175	Shared Neighborhood Hits	34
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNG2_HUMAN
NC score	0.065711 (rank : 83)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	145	Target Neighborhood Hits	83	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG4_HUMAN
NC score	0.064521 (rank : 84)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	145	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
NC score	0.059465 (rank : 85)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	145	Target Neighborhood Hits	99	Shared Neighborhood Hits	31
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA4_MOUSE
NC score	0.057770 (rank : 86)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	145	Target Neighborhood Hits	98	Shared Neighborhood Hits	24
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA4_HUMAN
NC score	0.057410 (rank : 87)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	145	Target Neighborhood Hits	108	Shared Neighborhood Hits	24
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNQ5_HUMAN
NC score	0.055948 (rank : 88)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	145	Target Neighborhood Hits	163	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

CABP5_MOUSE
NC score	0.054684 (rank : 89)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	145	Target Neighborhood Hits	207	Shared Neighborhood Hits	14
SwissProt Accessions	Q9JLK3	Gene names	Cabp5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

TRPV1_HUMAN
NC score	0.046264 (rank : 90)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	145	Target Neighborhood Hits	184	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPC4_HUMAN
NC score	0.045170 (rank : 91)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	145	Target Neighborhood Hits	140	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.044232 (rank : 92)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	145	Target Neighborhood Hits	141	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

CABP5_HUMAN
NC score	0.037672 (rank : 93)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	145	Target Neighborhood Hits	197	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NP86	Gene names	CABP5
Domain Architecture
Description	Calcium-binding protein 5 (CaBP5).

TRPV1_MOUSE
NC score	0.035349 (rank : 94)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	145	Target Neighborhood Hits	189	Shared Neighborhood Hits	18
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

IWS1_MOUSE
NC score	0.027977 (rank : 95)	θ value	2.36792 (rank : 89)
Query Neighborhood Hits	145	Target Neighborhood Hits	1258	Shared Neighborhood Hits	35
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

RERE_MOUSE
NC score	0.025593 (rank : 96)	θ value	0.0148317 (rank : 44)
Query Neighborhood Hits	145	Target Neighborhood Hits	785	Shared Neighborhood Hits	19
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

TARA_HUMAN
NC score	0.024922 (rank : 97)	θ value	0.0563607 (rank : 52)
Query Neighborhood Hits	145	Target Neighborhood Hits	1626	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

BSCL2_HUMAN
NC score	0.024247 (rank : 98)	θ value	0.62314 (rank : 73)
Query Neighborhood Hits	145	Target Neighborhood Hits	148	Shared Neighborhood Hits	9
SwissProt Accessions	Q96G97, Q96SV1, Q9BSQ0	Gene names	BSCL2
Domain Architecture	No domain graphic available
Description	Seipin (Bernardinelli-Seip congenital lipodystrophy type 2 protein).

TGON2_HUMAN
NC score	0.022645 (rank : 99)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	145	Target Neighborhood Hits	1037	Shared Neighborhood Hits	28
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

BAT2_MOUSE
NC score	0.020448 (rank : 100)	θ value	0.813845 (rank : 77)
Query Neighborhood Hits	145	Target Neighborhood Hits	947	Shared Neighborhood Hits	24
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

NELF_MOUSE
NC score	0.019234 (rank : 101)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	145	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q99NF2, Q8BPT0, Q8C9R5, Q9DBF4, Q9ERZ1	Gene names	Nelf, Jac
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor) (Juxtasynaptic attractor of caldendrin on dendritic boutons protein) (Jacob protein).

RERE_HUMAN
NC score	0.017938 (rank : 102)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	145	Target Neighborhood Hits	779	Shared Neighborhood Hits	19
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

TRPV5_HUMAN
NC score	0.017372 (rank : 103)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	145	Target Neighborhood Hits	261	Shared Neighborhood Hits	18
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

NELF_HUMAN
NC score	0.017264 (rank : 104)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	145	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q6X4W1, Q6X4V7, Q6X4V8, Q6X4V9, Q8N2M2, Q96SY1, Q9NPM4, Q9NPP3, Q9NPS3	Gene names	NELF
Domain Architecture	No domain graphic available
Description	Nasal embryonic luteinizing hormone-releasing hormone factor (Nasal embryonic LHRH factor).

CGRE1_MOUSE
NC score	0.017162 (rank : 105)	θ value	2.36792 (rank : 86)
Query Neighborhood Hits	145	Target Neighborhood Hits	173	Shared Neighborhood Hits	7
SwissProt Accessions	Q8R1U2, Q9D1K1	Gene names	Cgref1, Cgr11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

AKAP8_HUMAN
NC score	0.016414 (rank : 106)	θ value	0.21417 (rank : 61)
Query Neighborhood Hits	145	Target Neighborhood Hits	166	Shared Neighborhood Hits	5
SwissProt Accessions	O43823	Gene names	AKAP8, AKAP95
Domain Architecture
Description	A-kinase anchor protein 8 (A-kinase anchor protein 95 kDa) (AKAP 95).

MKL1_MOUSE
NC score	0.016044 (rank : 107)	θ value	0.279714 (rank : 66)
Query Neighborhood Hits	145	Target Neighborhood Hits	667	Shared Neighborhood Hits	20
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

DNMT1_MOUSE
NC score	0.013509 (rank : 108)	θ value	1.38821 (rank : 84)
Query Neighborhood Hits	145	Target Neighborhood Hits	137	Shared Neighborhood Hits	9
SwissProt Accessions	P13864, P97413, Q80ZU3, Q9CSC6, Q9QXX6	Gene names	Dnmt1, Dnmt, Met1, Uim
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase MmuI) (DNA MTase MmuI) (MCMT) (M.MmuI) (Met-1).

FBX7_HUMAN
NC score	0.013246 (rank : 109)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	145	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y3I1, Q5TGC4, Q96HM6, Q9UF21, Q9UKT2	Gene names	FBXO7, FBX7
Domain Architecture	No domain graphic available
Description	F-box only protein 7.

DREB_HUMAN
NC score	0.012125 (rank : 110)	θ value	0.62314 (rank : 74)
Query Neighborhood Hits	145	Target Neighborhood Hits	450	Shared Neighborhood Hits	13
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

T2FA_HUMAN
NC score	0.011986 (rank : 111)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	145	Target Neighborhood Hits	228	Shared Neighborhood Hits	12
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

PCLO_HUMAN
NC score	0.011959 (rank : 112)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	145	Target Neighborhood Hits	2046	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

AMPH_MOUSE
NC score	0.011767 (rank : 113)	θ value	1.06291 (rank : 79)
Query Neighborhood Hits	145	Target Neighborhood Hits	291	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

TFE2_HUMAN
NC score	0.011662 (rank : 114)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	145	Target Neighborhood Hits	161	Shared Neighborhood Hits	2
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

LYRIC_MOUSE
NC score	0.010768 (rank : 115)	θ value	2.36792 (rank : 90)
Query Neighborhood Hits	145	Target Neighborhood Hits	126	Shared Neighborhood Hits	5
SwissProt Accessions	Q80WJ7, Q3U9F8, Q3UAQ8, Q8BN67, Q8CBT9, Q8CDL0, Q8CGI7, Q9D052	Gene names	Mtdh, Lyric
Domain Architecture	No domain graphic available
Description	Protein LYRIC (Lysine-rich CEACAM1 co-isolated protein) (3D3/LYRIC) (Metastasis adhesion protein) (Metadherin).

TCO1_HUMAN
NC score	0.010437 (rank : 116)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	145	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P20061, Q8WV77	Gene names	TCN1, TC1
Domain Architecture
Description	Transcobalamin-1 precursor (Transcobalamin I) (TCI) (TC I).

NRIP1_MOUSE
NC score	0.009876 (rank : 117)	θ value	2.36792 (rank : 91)
Query Neighborhood Hits	145	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CBD1, Q8C3Y8, Q9Z2K2	Gene names	Nrip1
Domain Architecture	No domain graphic available
Description	Nuclear receptor-interacting protein 1 (Nuclear factor RIP140) (Receptor-interacting protein 140).

TB182_HUMAN
NC score	0.009775 (rank : 118)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	145	Target Neighborhood Hits	414	Shared Neighborhood Hits	14
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

NCBP1_HUMAN
NC score	0.009328 (rank : 119)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	145	Target Neighborhood Hits	46	Shared Neighborhood Hits	2
SwissProt Accessions	Q09161, Q59G76, Q5T1V0	Gene names	NCBP1, CBP80, NCBP
Domain Architecture
Description	Nuclear cap-binding protein subunit 1 (80 kDa nuclear cap-binding protein) (NCBP 80 kDa subunit) (CBP80).

GLGB_MOUSE
NC score	0.008566 (rank : 120)	θ value	4.03905 (rank : 101)
Query Neighborhood Hits	145	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D6Y9	Gene names	Gbe1
Domain Architecture	No domain graphic available
Description	1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (Glycogen branching enzyme) (Brancher enzyme).

MAP1A_HUMAN
NC score	0.008506 (rank : 121)	θ value	1.06291 (rank : 81)
Query Neighborhood Hits	145	Target Neighborhood Hits	1626	Shared Neighborhood Hits	29
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

HAIR_HUMAN
NC score	0.007688 (rank : 122)	θ value	2.36792 (rank : 88)
Query Neighborhood Hits	145	Target Neighborhood Hits	172	Shared Neighborhood Hits	6
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

KI13B_HUMAN
NC score	0.007173 (rank : 123)	θ value	0.0252991 (rank : 47)
Query Neighborhood Hits	145	Target Neighborhood Hits	492	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

SYN3_MOUSE
NC score	0.006572 (rank : 124)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	145	Target Neighborhood Hits	200	Shared Neighborhood Hits	11
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

MDC1_HUMAN
NC score	0.006461 (rank : 125)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	145	Target Neighborhood Hits	1446	Shared Neighborhood Hits	26
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MUC5B_HUMAN
NC score	0.006437 (rank : 126)	θ value	0.62314 (rank : 75)
Query Neighborhood Hits	145	Target Neighborhood Hits	1020	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

CI061_MOUSE
NC score	0.006201 (rank : 127)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	145	Target Neighborhood Hits	12	Shared Neighborhood Hits	2
SwissProt Accessions	Q4FZH1	Gene names	Gm967
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf61 homolog.

OSBP2_HUMAN
NC score	0.006160 (rank : 128)	θ value	2.36792 (rank : 92)
Query Neighborhood Hits	145	Target Neighborhood Hits	154	Shared Neighborhood Hits	10
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

CSTFT_MOUSE
NC score	0.006057 (rank : 129)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	145	Target Neighborhood Hits	356	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C7E9, Q6A016, Q8BHH7, Q8C3W7, Q8R2Y1, Q9EPU3	Gene names	Cstf2t, Kiaa0689
Domain Architecture	No domain graphic available
Description	Cleavage stimulation factor 64 kDa subunit, tau variant (CSTF 64 kDa subunit, tau variant) (CF-1 64 kDa subunit, tau variant) (TauCstF-64).

FANCG_MOUSE
NC score	0.005411 (rank : 130)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	145	Target Neighborhood Hits	19	Shared Neighborhood Hits	2
SwissProt Accessions	Q9EQR6	Gene names	Fancg
Domain Architecture	No domain graphic available
Description	Fanconi anemia group G protein homolog (Protein FACG).

AP3B1_MOUSE
NC score	0.005388 (rank : 131)	θ value	3.0926 (rank : 93)
Query Neighborhood Hits	145	Target Neighborhood Hits	302	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z1T1, Q91YR4	Gene names	Ap3b1
Domain Architecture
Description	AP-3 complex subunit beta-1 (Adapter-related protein complex 3 beta-1 subunit) (Beta3A-adaptin) (Adaptor protein complex AP-3 beta-1 subunit) (Clathrin assembly protein complex 3 beta-1 large chain).

CAD16_HUMAN
NC score	0.005179 (rank : 132)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	145	Target Neighborhood Hits	159	Shared Neighborhood Hits	3
SwissProt Accessions	O75309, Q6UW93	Gene names	CDH16
Domain Architecture
Description	Cadherin-16 precursor (Kidney-specific cadherin) (Ksp-cadherin).

EP400_HUMAN
NC score	0.005056 (rank : 133)	θ value	2.36792 (rank : 87)
Query Neighborhood Hits	145	Target Neighborhood Hits	556	Shared Neighborhood Hits	14
SwissProt Accessions	Q96L91, O15411, Q6P2F5, Q8N8Q7, Q8NE05, Q96JK7, Q9P230	Gene names	EP400, CAGH32, KIAA1498, KIAA1818, TNRC12
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (hDomino) (CAG repeat protein 32) (Trinucleotide repeat-containing gene 12 protein).

PSL1_HUMAN
NC score	0.004892 (rank : 134)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	145	Target Neighborhood Hits	650	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PIGN_MOUSE
NC score	0.004571 (rank : 135)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	145	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R1S3, Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2	Gene names	Pign
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N).

PHOS_HUMAN
NC score	0.004192 (rank : 136)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	145	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	P20941, Q14816	Gene names	PDC
Domain Architecture
Description	Phosducin (PHD) (33 kDa phototransducing protein) (MEKA protein).

FA26B_MOUSE
NC score	0.003878 (rank : 137)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	145	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEC4, Q3TDQ7, Q8BT85, Q8C246	Gene names	Fam26b
Domain Architecture	No domain graphic available
Description	Protein FAM26B.

RN168_HUMAN
NC score	0.003829 (rank : 138)	θ value	4.03905 (rank : 106)
Query Neighborhood Hits	145	Target Neighborhood Hits	370	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

LBXCO_MOUSE
NC score	0.003419 (rank : 139)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	145	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

EDD1_HUMAN
NC score	0.003145 (rank : 140)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	145	Target Neighborhood Hits	170	Shared Neighborhood Hits	5
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

TXLNB_HUMAN
NC score	0.003026 (rank : 141)	θ value	4.03905 (rank : 108)
Query Neighborhood Hits	145	Target Neighborhood Hits	912	Shared Neighborhood Hits	22
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

FCRLA_MOUSE
NC score	0.002663 (rank : 142)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	145	Target Neighborhood Hits	110	Shared Neighborhood Hits	3
SwissProt Accessions	Q920A9, Q3T9Q2, Q8K3U9, Q8VHP5	Gene names	Fcrla, Fcrl, Fcrl1, Fcrlm1, Fcrx, Freb
Domain Architecture	No domain graphic available
Description	Fc receptor-like and mucin-like 1 precursor (Fc receptor-like A) (Fc receptor homolog expressed in B-cells) (Fc receptor-related protein X) (FcRX) (Fc receptor-like protein).

TACC1_MOUSE
NC score	0.002548 (rank : 143)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	145	Target Neighborhood Hits	667	Shared Neighborhood Hits	12
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

CILP2_HUMAN
NC score	0.001982 (rank : 144)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	145	Target Neighborhood Hits	307	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

PTN22_MOUSE
NC score	0.001710 (rank : 145)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	145	Target Neighborhood Hits	179	Shared Neighborhood Hits	5
SwissProt Accessions	P29352, Q7TMP9	Gene names	Ptpn22, Ptpn8
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP).

MPP5_MOUSE
NC score	0.001196 (rank : 146)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	145	Target Neighborhood Hits	226	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLB2	Gene names	Mpp5, Pals1
Domain Architecture
Description	MAGUK p55 subfamily member 5 (Protein associated with Lin-7 1).

MPP5_HUMAN
NC score	0.001183 (rank : 147)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	145	Target Neighborhood Hits	231	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N3R9, Q7Z631, Q86T98, Q8N7I5, Q9H9Q0	Gene names	MPP5
Domain Architecture
Description	MAGUK p55 subfamily member 5.

ARHG1_HUMAN
NC score	0.001161 (rank : 148)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	145	Target Neighborhood Hits	176	Shared Neighborhood Hits	3
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

TBX19_HUMAN
NC score	0.001041 (rank : 149)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	145	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	O60806	Gene names	TBX19, TPIT
Domain Architecture
Description	T-box transcription factor TBX19 (T-box protein 19) (T-box factor, pituitary).

RGS12_HUMAN
NC score	0.000963 (rank : 150)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	145	Target Neighborhood Hits	333	Shared Neighborhood Hits	9
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

ABCA9_HUMAN
NC score	0.000592 (rank : 151)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	145	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IUA7, Q6P655, Q8N2S4, Q8WWZ5, Q96MD8	Gene names	ABCA9
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 9.

ESR1_HUMAN
NC score	0.000400 (rank : 152)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	145	Target Neighborhood Hits	105	Shared Neighborhood Hits	2
SwissProt Accessions	P03372, Q13511, Q14276, Q9NU51, Q9UDZ7, Q9UIS7	Gene names	ESR1, ESR, NR3A1
Domain Architecture
Description	Estrogen receptor (ER) (Estradiol receptor) (ER-alpha).

SC6A5_HUMAN
NC score	0.000398 (rank : 153)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	145	Target Neighborhood Hits	69	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y345, O95288, Q9BX77	Gene names	SLC6A5, GLYT2
Domain Architecture
Description	Sodium- and chloride-dependent glycine transporter 2 (GlyT2) (GlyT-2) (Solute carrier family 6 member 5).

ADA11_HUMAN
NC score	0.000349 (rank : 154)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	145	Target Neighborhood Hits	259	Shared Neighborhood Hits	3
SwissProt Accessions	O75078, Q14808, Q14809, Q14810	Gene names	ADAM11, MDC
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

UBP8_MOUSE
NC score	0.000317 (rank : 155)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	145	Target Neighborhood Hits	362	Shared Neighborhood Hits	10
SwissProt Accessions	Q80U87, Q80YP2, Q8R0D3, Q9EQU1, Q9WVP5	Gene names	Usp8, Kiaa0055, Ubpy
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (mUBPy).

HRH1_HUMAN
NC score	-0.000102 (rank : 156)	θ value	1.81305 (rank : 85)
Query Neighborhood Hits	145	Target Neighborhood Hits	916	Shared Neighborhood Hits	7
SwissProt Accessions	P35367	Gene names	HRH1
Domain Architecture
Description	Histamine H1 receptor.

MY18B_HUMAN
NC score	-0.000688 (rank : 157)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	145	Target Neighborhood Hits	1299	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

DLX1_HUMAN
NC score	-0.000716 (rank : 158)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	145	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	P56177, Q53ZU4, Q8IYB2	Gene names	DLX1
Domain Architecture
Description	Homeobox protein DLX-1.

DLX1_MOUSE
NC score	-0.000717 (rank : 159)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	145	Target Neighborhood Hits	343	Shared Neighborhood Hits	4
SwissProt Accessions	Q64317	Gene names	Dlx1
Domain Architecture
Description	Homeobox protein DLX-1.

OX2R_HUMAN
NC score	-0.000861 (rank : 160)	θ value	1.06291 (rank : 82)
Query Neighborhood Hits	145	Target Neighborhood Hits	929	Shared Neighborhood Hits	6
SwissProt Accessions	O43614	Gene names	HCRTR2
Domain Architecture
Description	Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2).

OX2R_MOUSE
NC score	-0.000870 (rank : 161)	θ value	1.06291 (rank : 83)
Query Neighborhood Hits	145	Target Neighborhood Hits	921	Shared Neighborhood Hits	6
SwissProt Accessions	P58308, Q5SGC8, Q6VLX3, Q8BG12	Gene names	Hcrtr2, Mox2r
Domain Architecture
Description	Orexin receptor type 2 (Ox2r) (Hypocretin receptor type 2).

HXC10_HUMAN
NC score	-0.001444 (rank : 162)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	145	Target Neighborhood Hits	417	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYD6, O15219, O15220, Q9BVD5	Gene names	HOXC10
Domain Architecture
Description	Homeobox protein Hox-C10.

OLF9_MOUSE
NC score	-0.001713 (rank : 163)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	145	Target Neighborhood Hits	700	Shared Neighborhood Hits	12
SwissProt Accessions	Q60885, Q8VGC0	Gene names	Olfr9, Mor269-3
Domain Architecture	No domain graphic available
Description	Olfactory receptor 9 (Olfactory receptor 269-3) (Odorant receptor M25).

CUBN_MOUSE
NC score	-0.001782 (rank : 164)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	145	Target Neighborhood Hits	477	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

OBSCN_HUMAN
NC score	-0.004837 (rank : 165)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	145	Target Neighborhood Hits	1931	Shared Neighborhood Hits	22
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

EPHB3_MOUSE
NC score	-0.005286 (rank : 166)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	145	Target Neighborhood Hits	996	Shared Neighborhood Hits	3
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).