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Network neighborhood for query Sequence : PKDRE_MOUSE

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PKDRE_MOUSE
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKDRE_HUMAN
θ value	0 (rank : 1)	NC score	0.984787 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	64	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PK1L1_HUMAN
θ value	3.07116e-24 (rank : 3)	NC score	0.586976 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	140	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

PK2L1_HUMAN
θ value	6.40375e-22 (rank : 4)	NC score	0.574301 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_MOUSE
θ value	2.43343e-21 (rank : 5)	NC score	0.579567 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	99	Shared Neighborhood Hits	29
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PK2L2_MOUSE
θ value	9.24701e-21 (rank : 6)	NC score	0.577463 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	84	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_HUMAN
θ value	2.97466e-19 (rank : 7)	NC score	0.571020 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	105	Shared Neighborhood Hits	29
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PKD1_HUMAN
θ value	1.92812e-18 (rank : 8)	NC score	0.324611 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	387	Shared Neighborhood Hits	16
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

PK2L2_HUMAN
θ value	5.60996e-18 (rank : 9)	NC score	0.559714 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	90	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

LOX5_HUMAN
θ value	1.74796e-11 (rank : 10)	NC score	0.250935 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	P09917	Gene names	ALOX5, LOG5
Domain Architecture
Description	Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).

LOX5_MOUSE
θ value	4.30538e-10 (rank : 11)	NC score	0.240116 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	P48999	Gene names	Alox5
Domain Architecture
Description	Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).

MCLN1_HUMAN
θ value	9.92553e-07 (rank : 12)	NC score	0.303518 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

MCLN1_MOUSE
θ value	4.92598e-06 (rank : 13)	NC score	0.296773 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

LX12B_HUMAN
θ value	7.1131e-05 (rank : 14)	NC score	0.177979 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	O75342	Gene names	ALOX12B
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12R type (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (12R-lipoxygenase) (12R-LOX).

MCLN3_HUMAN
θ value	0.000158464 (rank : 15)	NC score	0.296263 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN3_MOUSE
θ value	0.000270298 (rank : 16)	NC score	0.291543 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

LX12B_MOUSE
θ value	0.00134147 (rank : 17)	NC score	0.170147 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	O70582	Gene names	Alox12b, Aloxe2
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12R type (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (12R-lipoxygenase) (12R-LOX) (Epidermis-type lipoxygenase 2) (e-LOX 2).

SCN5A_HUMAN
θ value	0.00175202 (rank : 18)	NC score	0.120938 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	145	Shared Neighborhood Hits	21
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

MCLN2_HUMAN
θ value	0.00298849 (rank : 19)	NC score	0.278362 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

SC10A_HUMAN
θ value	0.0148317 (rank : 20)	NC score	0.107034 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	116	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

MCLN2_MOUSE
θ value	0.0252991 (rank : 21)	NC score	0.272470 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

RA6I1_HUMAN
θ value	0.0330416 (rank : 22)	NC score	0.102268 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IQ26, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1	Gene names	RAB6IP1, KIAA1091
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

RA6I1_MOUSE
θ value	0.0563607 (rank : 23)	NC score	0.097947 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PAL8, Q62146, Q8C829, Q8VDF6, Q9QYZ2	Gene names	Rab6ip1
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

CEND3_HUMAN
θ value	0.125558 (rank : 24)	NC score	0.029246 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	275	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

SC10A_MOUSE
θ value	0.125558 (rank : 25)	NC score	0.100587 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

LIPE_MOUSE
θ value	0.163984 (rank : 26)	NC score	0.048975 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WVG5, Q8VDU2	Gene names	Lipg
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL).

LOXE3_HUMAN
θ value	0.163984 (rank : 27)	NC score	0.148842 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BYJ1, Q9H4F2, Q9HC22	Gene names	ALOXE3
Domain Architecture
Description	Epidermis-type lipoxygenase 3 (EC 1.13.11.-) (e-LOX-3).

LOXE3_MOUSE
θ value	0.163984 (rank : 28)	NC score	0.156018 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WV07	Gene names	Aloxe3
Domain Architecture
Description	Epidermis-type lipoxygenase 3 (EC 1.13.11.-) (e-LOX-3).

CP3A7_HUMAN
θ value	0.279714 (rank : 29)	NC score	0.011952 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	P24462	Gene names	CYP3A7
Domain Architecture
Description	Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA).

LX15B_MOUSE
θ value	0.365318 (rank : 30)	NC score	0.146692 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O35936	Gene names	Alox15b, Alox8
Domain Architecture
Description	Arachidonate 15-lipoxygenase type II (EC 1.13.11.33) (15-LOX-2) (8S- lipoxygenase) (8S-LOX).

LOX12_HUMAN
θ value	0.47712 (rank : 31)	NC score	0.138467 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	P18054, O95569, Q6ISF8, Q9UQM4	Gene names	ALOX12, LOG12
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12S-type (EC 1.13.11.31) (12-LOX) (Platelet-type lipoxygenase 12).

SCN9A_HUMAN
θ value	0.47712 (rank : 32)	NC score	0.093349 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	157	Shared Neighborhood Hits	23
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

TAP1_HUMAN
θ value	0.47712 (rank : 33)	NC score	0.014702 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q03518, Q16149	Gene names	TAP1, ABCB2, PSF1, RING4, Y3
Domain Architecture
Description	Antigen peptide transporter 1 (APT1) (Peptide transporter TAP1) (ATP- binding cassette sub-family B member 2) (Peptide transporter PSF1) (Peptide supply factor 1) (PSF-1) (Peptide transporter involved in antigen processing 1).

SCN3A_HUMAN
θ value	0.62314 (rank : 34)	NC score	0.093052 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

LIPE_HUMAN
θ value	0.813845 (rank : 35)	NC score	0.048837 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	25	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5X9, Q6UW82	Gene names	LIPG
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL).

NOS1_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.013994 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	218	Shared Neighborhood Hits	3
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

SCN1A_HUMAN
θ value	1.38821 (rank : 37)	NC score	0.093793 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	21
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	1.38821 (rank : 38)	NC score	0.093240 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	157	Shared Neighborhood Hits	21
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

DOS_HUMAN
θ value	1.81305 (rank : 39)	NC score	0.038840 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N350, O43385	Gene names	DOS, C19orf26
Domain Architecture	No domain graphic available
Description	Protein Dos.

EWS_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.026129 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	249	Shared Neighborhood Hits	4
SwissProt Accessions	Q01844, Q92635	Gene names	EWSR1, EWS
Domain Architecture
Description	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).

EWS_MOUSE
θ value	1.81305 (rank : 41)	NC score	0.025554 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q61545	Gene names	Ewsr1, Ews, Ewsh
Domain Architecture
Description	RNA-binding protein EWS.

LX12L_MOUSE
θ value	1.81305 (rank : 42)	NC score	0.136673 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P39654, Q4FJY9, Q5F2E3, Q6PHB2	Gene names	Alox12l, Alox15
Domain Architecture
Description	Arachidonate 12-lipoxygenase, leukocyte-type (EC 1.13.11.31) (12-LOX).

SCN4A_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.087595 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	133	Shared Neighborhood Hits	21
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN8A_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.087104 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	1.81305 (rank : 45)	NC score	0.087215 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	136	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SDK1_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.005825 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	511	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

CAC1E_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.083504 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	24
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	2.36792 (rank : 48)	NC score	0.083806 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	167	Shared Neighborhood Hits	23
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

FBXL8_HUMAN
θ value	2.36792 (rank : 49)	NC score	0.026938 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q96CD0, Q9NUM0	Gene names	FBXL8, FBL8
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8).

PLEC1_HUMAN
θ value	2.36792 (rank : 50)	NC score	0.004104 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	1326	Shared Neighborhood Hits	5
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

U689_MOUSE
θ value	2.36792 (rank : 51)	NC score	0.034667 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D3J8	Gene names
Domain Architecture	No domain graphic available
Description	Protein UNQ689/PRO1329 homolog precursor.

ANR26_MOUSE
θ value	3.0926 (rank : 52)	NC score	0.003015 (rank : 92)
Query Neighborhood Hits	76	Target Neighborhood Hits	1554	Shared Neighborhood Hits	6
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

BAIP3_MOUSE
θ value	3.0926 (rank : 53)	NC score	0.014218 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

LX15B_HUMAN
θ value	3.0926 (rank : 54)	NC score	0.142244 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	O15296, Q8IYQ2, Q8TEV3, Q8TEV4, Q8TEV5, Q8TEV6, Q9UKM4	Gene names	ALOX15B
Domain Architecture
Description	Arachidonate 15-lipoxygenase type II (EC 1.13.11.33) (15-LOX-2) (15- lipoxygenase 2).

KNTC2_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.007967 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	673	Shared Neighborhood Hits	4
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

LOX12_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.134806 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	P39655, Q8BHG4	Gene names	Alox12, Alox12p
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12S-type (EC 1.13.11.31) (12-LOX) (Platelet-type lipoxygenase 12).

O51B2_HUMAN
θ value	4.03905 (rank : 57)	NC score	-0.000680 (rank : 94)
Query Neighborhood Hits	76	Target Neighborhood Hits	657	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5P1, Q96RD4	Gene names	OR51B2
Domain Architecture
Description	Olfactory receptor 51B2 (Odorant receptor HOR5'beta3).

OTU7A_MOUSE
θ value	4.03905 (rank : 58)	NC score	0.014683 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R554	Gene names	Otud7a, Otud7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

CALR3_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.012648 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D9Q6	Gene names	Calr3, Crt2
Domain Architecture
Description	Calreticulin-3 precursor (Calreticulin-2).

DIP2A_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.018487 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q14689, Q8IVA3, Q8N4S2, Q8TD89, Q96ML9	Gene names	DIP2A, C21orf106, DIP2, KIAA0184
Domain Architecture
Description	Disco-interacting protein 2 homolog A.

DIP2A_MOUSE
θ value	5.27518 (rank : 61)	NC score	0.018824 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWT5, Q8CHI0	Gene names	Dip2a, Dip2, Kiaa0184
Domain Architecture
Description	Disco-interacting protein 2 homolog A.

NEP_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.008204 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

ABCG1_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.007565 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q64343	Gene names	Abcg1, Abc8, Wht1
Domain Architecture
Description	ATP-binding cassette sub-family G member 1 (White protein homolog) (ATP-binding cassette transporter 8).

PACS1_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.013355 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K212, Q6P5H8	Gene names	Pacs1
Domain Architecture	No domain graphic available
Description	Phosphofurin acidic cluster sorting protein 1 (PACS-1).

PAIP1_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.013074 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H074, O60455, Q96B61, Q9BS63	Gene names	PAIP1
Domain Architecture
Description	Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1) (PABP-interacting protein 1) (PAIP-1).

SC11A_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.094477 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	116	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

TAU_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.011737 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	448	Shared Neighborhood Hits	6
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

ANDR_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.003046 (rank : 91)
Query Neighborhood Hits	76	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

CAC1G_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.072104 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	587	Shared Neighborhood Hits	27
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

LAP4B_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.011950 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q86VI4, Q3ZCV5, Q7L909, Q86VH8, Q9H060	Gene names	LAPTM4B
Domain Architecture	No domain graphic available
Description	Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta).

MAGE1_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.004749 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	1389	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MAP2_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.009968 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	342	Shared Neighborhood Hits	4
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

NFASC_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.002752 (rank : 93)
Query Neighborhood Hits	76	Target Neighborhood Hits	497	Shared Neighborhood Hits	4
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NKTR_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.003784 (rank : 90)
Query Neighborhood Hits	76	Target Neighborhood Hits	658	Shared Neighborhood Hits	6
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

TBX18_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.003930 (rank : 89)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	O95935, Q7Z6U4, Q9UJI6	Gene names	TBX18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

TTF2_MOUSE
θ value	8.99809 (rank : 76)	NC score	0.004977 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	364	Shared Neighborhood Hits	4
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

CAC1A_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.065200 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	387	Shared Neighborhood Hits	26
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.065501 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.074000 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1B_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.070533 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	351	Shared Neighborhood Hits	26
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1C_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.072087 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	158	Shared Neighborhood Hits	20
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1C_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.078353 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	130	Shared Neighborhood Hits	20
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1D_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.068896 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	118	Shared Neighborhood Hits	20
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1F_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.072182 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	141	Shared Neighborhood Hits	19
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.078926 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	142	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1H_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.061383 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1H_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.054337 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	230	Shared Neighborhood Hits	21
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1I_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.069511 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	138	Shared Neighborhood Hits	20
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1S_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.065576 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.065056 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

LOX15_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.125575 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	P16050, Q8N6R7, Q99657	Gene names	ALOX15, LOG15
Domain Architecture
Description	Arachidonate 15-lipoxygenase (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (15-LOX).

LX12E_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.129563 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	P55249, Q91YW6	Gene names	Alox12e, Alox12-ps2, Aloxe
Domain Architecture
Description	Arachidonate 12-lipoxygenase, epidermal-type (EC 1.13.11.31) (12-LOX).

SC11A_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.096677 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN7A_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.070325 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	135	Shared Neighborhood Hits	20
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

Hits sorted by NC score

PKDRE_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_HUMAN
NC score	0.984787 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	76	Target Neighborhood Hits	64	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PK1L1_HUMAN
NC score	0.586976 (rank : 3)	θ value	3.07116e-24 (rank : 3)
Query Neighborhood Hits	76	Target Neighborhood Hits	140	Shared Neighborhood Hits	19
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

PKD2_MOUSE
NC score	0.579567 (rank : 4)	θ value	2.43343e-21 (rank : 5)
Query Neighborhood Hits	76	Target Neighborhood Hits	99	Shared Neighborhood Hits	29
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PK2L2_MOUSE
NC score	0.577463 (rank : 5)	θ value	9.24701e-21 (rank : 6)
Query Neighborhood Hits	76	Target Neighborhood Hits	84	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.574301 (rank : 6)	θ value	6.40375e-22 (rank : 4)
Query Neighborhood Hits	76	Target Neighborhood Hits	132	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_HUMAN
NC score	0.571020 (rank : 7)	θ value	2.97466e-19 (rank : 7)
Query Neighborhood Hits	76	Target Neighborhood Hits	105	Shared Neighborhood Hits	29
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PK2L2_HUMAN
NC score	0.559714 (rank : 8)	θ value	5.60996e-18 (rank : 9)
Query Neighborhood Hits	76	Target Neighborhood Hits	90	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD1_HUMAN
NC score	0.324611 (rank : 9)	θ value	1.92812e-18 (rank : 8)
Query Neighborhood Hits	76	Target Neighborhood Hits	387	Shared Neighborhood Hits	16
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

MCLN1_HUMAN
NC score	0.303518 (rank : 10)	θ value	9.92553e-07 (rank : 12)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

MCLN1_MOUSE
NC score	0.296773 (rank : 11)	θ value	4.92598e-06 (rank : 13)
Query Neighborhood Hits	76	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

MCLN3_HUMAN
NC score	0.296263 (rank : 12)	θ value	0.000158464 (rank : 15)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN3_MOUSE
NC score	0.291543 (rank : 13)	θ value	0.000270298 (rank : 16)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN2_HUMAN
NC score	0.278362 (rank : 14)	θ value	0.00298849 (rank : 19)
Query Neighborhood Hits	76	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN2_MOUSE
NC score	0.272470 (rank : 15)	θ value	0.0252991 (rank : 21)
Query Neighborhood Hits	76	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

LOX5_HUMAN
NC score	0.250935 (rank : 16)	θ value	1.74796e-11 (rank : 10)
Query Neighborhood Hits	76	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	P09917	Gene names	ALOX5, LOG5
Domain Architecture
Description	Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).

LOX5_MOUSE
NC score	0.240116 (rank : 17)	θ value	4.30538e-10 (rank : 11)
Query Neighborhood Hits	76	Target Neighborhood Hits	21	Shared Neighborhood Hits	15
SwissProt Accessions	P48999	Gene names	Alox5
Domain Architecture
Description	Arachidonate 5-lipoxygenase (EC 1.13.11.34) (5-lipoxygenase) (5-LO).

LX12B_HUMAN
NC score	0.177979 (rank : 18)	θ value	7.1131e-05 (rank : 14)
Query Neighborhood Hits	76	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	O75342	Gene names	ALOX12B
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12R type (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (12R-lipoxygenase) (12R-LOX).

LX12B_MOUSE
NC score	0.170147 (rank : 19)	θ value	0.00134147 (rank : 17)
Query Neighborhood Hits	76	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	O70582	Gene names	Alox12b, Aloxe2
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12R type (EC 1.13.11.-) (Epidermis-type lipoxygenase 12) (12R-lipoxygenase) (12R-LOX) (Epidermis-type lipoxygenase 2) (e-LOX 2).

LOXE3_MOUSE
NC score	0.156018 (rank : 20)	θ value	0.163984 (rank : 28)
Query Neighborhood Hits	76	Target Neighborhood Hits	19	Shared Neighborhood Hits	13
SwissProt Accessions	Q9WV07	Gene names	Aloxe3
Domain Architecture
Description	Epidermis-type lipoxygenase 3 (EC 1.13.11.-) (e-LOX-3).

LOXE3_HUMAN
NC score	0.148842 (rank : 21)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	76	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BYJ1, Q9H4F2, Q9HC22	Gene names	ALOXE3
Domain Architecture
Description	Epidermis-type lipoxygenase 3 (EC 1.13.11.-) (e-LOX-3).

LX15B_MOUSE
NC score	0.146692 (rank : 22)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	O35936	Gene names	Alox15b, Alox8
Domain Architecture
Description	Arachidonate 15-lipoxygenase type II (EC 1.13.11.33) (15-LOX-2) (8S- lipoxygenase) (8S-LOX).

LX15B_HUMAN
NC score	0.142244 (rank : 23)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	76	Target Neighborhood Hits	25	Shared Neighborhood Hits	13
SwissProt Accessions	O15296, Q8IYQ2, Q8TEV3, Q8TEV4, Q8TEV5, Q8TEV6, Q9UKM4	Gene names	ALOX15B
Domain Architecture
Description	Arachidonate 15-lipoxygenase type II (EC 1.13.11.33) (15-LOX-2) (15- lipoxygenase 2).

LOX12_HUMAN
NC score	0.138467 (rank : 24)	θ value	0.47712 (rank : 31)
Query Neighborhood Hits	76	Target Neighborhood Hits	19	Shared Neighborhood Hits	12
SwissProt Accessions	P18054, O95569, Q6ISF8, Q9UQM4	Gene names	ALOX12, LOG12
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12S-type (EC 1.13.11.31) (12-LOX) (Platelet-type lipoxygenase 12).

LX12L_MOUSE
NC score	0.136673 (rank : 25)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	76	Target Neighborhood Hits	15	Shared Neighborhood Hits	13
SwissProt Accessions	P39654, Q4FJY9, Q5F2E3, Q6PHB2	Gene names	Alox12l, Alox15
Domain Architecture
Description	Arachidonate 12-lipoxygenase, leukocyte-type (EC 1.13.11.31) (12-LOX).

LOX12_MOUSE
NC score	0.134806 (rank : 26)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	76	Target Neighborhood Hits	24	Shared Neighborhood Hits	13
SwissProt Accessions	P39655, Q8BHG4	Gene names	Alox12, Alox12p
Domain Architecture
Description	Arachidonate 12-lipoxygenase, 12S-type (EC 1.13.11.31) (12-LOX) (Platelet-type lipoxygenase 12).

LX12E_MOUSE
NC score	0.129563 (rank : 27)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	76	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	P55249, Q91YW6	Gene names	Alox12e, Alox12-ps2, Aloxe
Domain Architecture
Description	Arachidonate 12-lipoxygenase, epidermal-type (EC 1.13.11.31) (12-LOX).

LOX15_HUMAN
NC score	0.125575 (rank : 28)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	P16050, Q8N6R7, Q99657	Gene names	ALOX15, LOG15
Domain Architecture
Description	Arachidonate 15-lipoxygenase (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (15-LOX).

SCN5A_HUMAN
NC score	0.120938 (rank : 29)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	76	Target Neighborhood Hits	145	Shared Neighborhood Hits	21
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SC10A_HUMAN
NC score	0.107034 (rank : 30)	θ value	0.0148317 (rank : 20)
Query Neighborhood Hits	76	Target Neighborhood Hits	116	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

RA6I1_HUMAN
NC score	0.102268 (rank : 31)	θ value	0.0330416 (rank : 22)
Query Neighborhood Hits	76	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IQ26, Q96GN3, Q9H6U7, Q9UFV0, Q9UPR1	Gene names	RAB6IP1, KIAA1091
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

SC10A_MOUSE
NC score	0.100587 (rank : 32)	θ value	0.125558 (rank : 25)
Query Neighborhood Hits	76	Target Neighborhood Hits	107	Shared Neighborhood Hits	21
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

RA6I1_MOUSE
NC score	0.097947 (rank : 33)	θ value	0.0563607 (rank : 23)
Query Neighborhood Hits	76	Target Neighborhood Hits	57	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PAL8, Q62146, Q8C829, Q8VDF6, Q9QYZ2	Gene names	Rab6ip1
Domain Architecture	No domain graphic available
Description	Rab6-interacting protein 1 (Rab6IP1).

SC11A_HUMAN
NC score	0.096677 (rank : 34)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	76	Target Neighborhood Hits	111	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SC11A_MOUSE
NC score	0.094477 (rank : 35)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	76	Target Neighborhood Hits	116	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN1A_HUMAN
NC score	0.093793 (rank : 36)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	21
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN9A_HUMAN
NC score	0.093349 (rank : 37)	θ value	0.47712 (rank : 32)
Query Neighborhood Hits	76	Target Neighborhood Hits	157	Shared Neighborhood Hits	23
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN2A_HUMAN
NC score	0.093240 (rank : 38)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	76	Target Neighborhood Hits	157	Shared Neighborhood Hits	21
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
NC score	0.093052 (rank : 39)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	21
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
NC score	0.087595 (rank : 40)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	76	Target Neighborhood Hits	133	Shared Neighborhood Hits	21
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN8A_MOUSE
NC score	0.087215 (rank : 41)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	76	Target Neighborhood Hits	136	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_HUMAN
NC score	0.087104 (rank : 42)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	76	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1E_MOUSE
NC score	0.083806 (rank : 43)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	76	Target Neighborhood Hits	167	Shared Neighborhood Hits	23
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.083504 (rank : 44)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	24
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1F_MOUSE
NC score	0.078926 (rank : 45)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	76	Target Neighborhood Hits	142	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.078353 (rank : 46)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	76	Target Neighborhood Hits	130	Shared Neighborhood Hits	20
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1B_HUMAN
NC score	0.074000 (rank : 47)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	76	Target Neighborhood Hits	257	Shared Neighborhood Hits	26
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1F_HUMAN
NC score	0.072182 (rank : 48)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	76	Target Neighborhood Hits	141	Shared Neighborhood Hits	19
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1G_HUMAN
NC score	0.072104 (rank : 49)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	76	Target Neighborhood Hits	587	Shared Neighborhood Hits	27
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CAC1C_HUMAN
NC score	0.072087 (rank : 50)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	76	Target Neighborhood Hits	158	Shared Neighborhood Hits	20
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1B_MOUSE
NC score	0.070533 (rank : 51)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	76	Target Neighborhood Hits	351	Shared Neighborhood Hits	26
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

SCN7A_HUMAN
NC score	0.070325 (rank : 52)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	76	Target Neighborhood Hits	135	Shared Neighborhood Hits	20
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

CAC1I_HUMAN
NC score	0.069511 (rank : 53)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	76	Target Neighborhood Hits	138	Shared Neighborhood Hits	20
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1D_HUMAN
NC score	0.068896 (rank : 54)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	76	Target Neighborhood Hits	118	Shared Neighborhood Hits	20
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1S_HUMAN
NC score	0.065576 (rank : 55)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	76	Target Neighborhood Hits	92	Shared Neighborhood Hits	19
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1A_MOUSE
NC score	0.065501 (rank : 56)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	76	Target Neighborhood Hits	267	Shared Neighborhood Hits	26
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_HUMAN
NC score	0.065200 (rank : 57)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	76	Target Neighborhood Hits	387	Shared Neighborhood Hits	26
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1S_MOUSE
NC score	0.065056 (rank : 58)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	76	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1H_HUMAN
NC score	0.061383 (rank : 59)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	76	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1H_MOUSE
NC score	0.054337 (rank : 60)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	76	Target Neighborhood Hits	230	Shared Neighborhood Hits	21
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

LIPE_MOUSE
NC score	0.048975 (rank : 61)	θ value	0.163984 (rank : 26)
Query Neighborhood Hits	76	Target Neighborhood Hits	20	Shared Neighborhood Hits	5
SwissProt Accessions	Q9WVG5, Q8VDU2	Gene names	Lipg
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL).

LIPE_HUMAN
NC score	0.048837 (rank : 62)	θ value	0.813845 (rank : 35)
Query Neighborhood Hits	76	Target Neighborhood Hits	25	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y5X9, Q6UW82	Gene names	LIPG
Domain Architecture
Description	Endothelial lipase precursor (EC 3.1.1.3) (Endothelial cell-derived lipase) (EDL) (EL).

DOS_HUMAN
NC score	0.038840 (rank : 63)	θ value	1.81305 (rank : 39)
Query Neighborhood Hits	76	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q8N350, O43385	Gene names	DOS, C19orf26
Domain Architecture	No domain graphic available
Description	Protein Dos.

U689_MOUSE
NC score	0.034667 (rank : 64)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	76	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D3J8	Gene names
Domain Architecture	No domain graphic available
Description	Protein UNQ689/PRO1329 homolog precursor.

CEND3_HUMAN
NC score	0.029246 (rank : 65)	θ value	0.125558 (rank : 24)
Query Neighborhood Hits	76	Target Neighborhood Hits	275	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

FBXL8_HUMAN
NC score	0.026938 (rank : 66)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	76	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q96CD0, Q9NUM0	Gene names	FBXL8, FBL8
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8).

EWS_HUMAN
NC score	0.026129 (rank : 67)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	76	Target Neighborhood Hits	249	Shared Neighborhood Hits	4
SwissProt Accessions	Q01844, Q92635	Gene names	EWSR1, EWS
Domain Architecture
Description	RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein).

EWS_MOUSE
NC score	0.025554 (rank : 68)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	76	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q61545	Gene names	Ewsr1, Ews, Ewsh
Domain Architecture
Description	RNA-binding protein EWS.

DIP2A_MOUSE
NC score	0.018824 (rank : 69)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	76	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BWT5, Q8CHI0	Gene names	Dip2a, Dip2, Kiaa0184
Domain Architecture
Description	Disco-interacting protein 2 homolog A.

DIP2A_HUMAN
NC score	0.018487 (rank : 70)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	76	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q14689, Q8IVA3, Q8N4S2, Q8TD89, Q96ML9	Gene names	DIP2A, C21orf106, DIP2, KIAA0184
Domain Architecture
Description	Disco-interacting protein 2 homolog A.

TAP1_HUMAN
NC score	0.014702 (rank : 71)	θ value	0.47712 (rank : 33)
Query Neighborhood Hits	76	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	Q03518, Q16149	Gene names	TAP1, ABCB2, PSF1, RING4, Y3
Domain Architecture
Description	Antigen peptide transporter 1 (APT1) (Peptide transporter TAP1) (ATP- binding cassette sub-family B member 2) (Peptide transporter PSF1) (Peptide supply factor 1) (PSF-1) (Peptide transporter involved in antigen processing 1).

OTU7A_MOUSE
NC score	0.014683 (rank : 72)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	76	Target Neighborhood Hits	91	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R554	Gene names	Otud7a, Otud7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

BAIP3_MOUSE
NC score	0.014218 (rank : 73)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	76	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q80TT2, Q6RUT4	Gene names	Baiap3, Gm937, Kiaa0734
Domain Architecture	No domain graphic available
Description	BAI1-associated protein 3 (BAP3).

NOS1_HUMAN
NC score	0.013994 (rank : 74)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	76	Target Neighborhood Hits	218	Shared Neighborhood Hits	3
SwissProt Accessions	P29475	Gene names	NOS1
Domain Architecture
Description	Nitric-oxide synthase, brain (EC 1.14.13.39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS).

PACS1_MOUSE
NC score	0.013355 (rank : 75)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	76	Target Neighborhood Hits	87	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K212, Q6P5H8	Gene names	Pacs1
Domain Architecture	No domain graphic available
Description	Phosphofurin acidic cluster sorting protein 1 (PACS-1).

PAIP1_HUMAN
NC score	0.013074 (rank : 76)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	76	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H074, O60455, Q96B61, Q9BS63	Gene names	PAIP1
Domain Architecture
Description	Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1) (PABP-interacting protein 1) (PAIP-1).

CALR3_MOUSE
NC score	0.012648 (rank : 77)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	76	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D9Q6	Gene names	Calr3, Crt2
Domain Architecture
Description	Calreticulin-3 precursor (Calreticulin-2).

CP3A7_HUMAN
NC score	0.011952 (rank : 78)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	76	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	P24462	Gene names	CYP3A7
Domain Architecture
Description	Cytochrome P450 3A7 (EC 1.14.14.1) (CYPIIIA7) (P450-HFLA).

LAP4B_HUMAN
NC score	0.011950 (rank : 79)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	76	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q86VI4, Q3ZCV5, Q7L909, Q86VH8, Q9H060	Gene names	LAPTM4B
Domain Architecture	No domain graphic available
Description	Lysosomal-associated transmembrane protein 4B (Lysosome-associated transmembrane protein 4-beta).

TAU_HUMAN
NC score	0.011737 (rank : 80)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	76	Target Neighborhood Hits	448	Shared Neighborhood Hits	6
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

MAP2_MOUSE
NC score	0.009968 (rank : 81)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	76	Target Neighborhood Hits	342	Shared Neighborhood Hits	4
SwissProt Accessions	P20357	Gene names	Map2, Mtap2
Domain Architecture
Description	Microtubule-associated protein 2 (MAP 2).

NEP_MOUSE
NC score	0.008204 (rank : 82)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	76	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q61391, Q6NXX5, Q8K251	Gene names	Mme
Domain Architecture
Description	Neprilysin (EC 3.4.24.11) (Neutral endopeptidase) (NEP) (Enkephalinase) (Neutral endopeptidase 24.11) (Atriopeptidase) (CD10 antigen).

KNTC2_HUMAN
NC score	0.007967 (rank : 83)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	76	Target Neighborhood Hits	673	Shared Neighborhood Hits	4
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

ABCG1_MOUSE
NC score	0.007565 (rank : 84)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	76	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q64343	Gene names	Abcg1, Abc8, Wht1
Domain Architecture
Description	ATP-binding cassette sub-family G member 1 (White protein homolog) (ATP-binding cassette transporter 8).

SDK1_HUMAN
NC score	0.005825 (rank : 85)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	76	Target Neighborhood Hits	511	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

TTF2_MOUSE
NC score	0.004977 (rank : 86)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	76	Target Neighborhood Hits	364	Shared Neighborhood Hits	4
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

MAGE1_HUMAN
NC score	0.004749 (rank : 87)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	76	Target Neighborhood Hits	1389	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PLEC1_HUMAN
NC score	0.004104 (rank : 88)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	76	Target Neighborhood Hits	1326	Shared Neighborhood Hits	5
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

TBX18_HUMAN
NC score	0.003930 (rank : 89)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	76	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	O95935, Q7Z6U4, Q9UJI6	Gene names	TBX18
Domain Architecture
Description	T-box transcription factor TBX18 (T-box protein 18).

NKTR_HUMAN
NC score	0.003784 (rank : 90)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	76	Target Neighborhood Hits	658	Shared Neighborhood Hits	6
SwissProt Accessions	P30414	Gene names	NKTR
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

ANDR_MOUSE
NC score	0.003046 (rank : 91)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	76	Target Neighborhood Hits	133	Shared Neighborhood Hits	2
SwissProt Accessions	P19091	Gene names	Ar, Nr3c4
Domain Architecture
Description	Androgen receptor (Dihydrotestosterone receptor).

ANR26_MOUSE
NC score	0.003015 (rank : 92)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	76	Target Neighborhood Hits	1554	Shared Neighborhood Hits	6
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

NFASC_HUMAN
NC score	0.002752 (rank : 93)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	76	Target Neighborhood Hits	497	Shared Neighborhood Hits	4
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

O51B2_HUMAN
NC score	-0.000680 (rank : 94)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	76	Target Neighborhood Hits	657	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y5P1, Q96RD4	Gene names	OR51B2
Domain Architecture
Description	Olfactory receptor 51B2 (Odorant receptor HOR5'beta3).