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Network neighborhood for query Sequence : PK2L1_HUMAN

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PK2L1_HUMAN
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PK2L1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	132	Target Neighborhood Hits	132	Shared Neighborhood Hits	132
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_HUMAN
θ value	0 (rank : 2)	NC score	0.969112 (rank : 2)
Query Neighborhood Hits	132	Target Neighborhood Hits	105	Shared Neighborhood Hits	69
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PKD2_MOUSE
θ value	0 (rank : 3)	NC score	0.967132 (rank : 3)
Query Neighborhood Hits	132	Target Neighborhood Hits	99	Shared Neighborhood Hits	66
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PK2L2_HUMAN
θ value	1.42583e-138 (rank : 4)	NC score	0.961548 (rank : 5)
Query Neighborhood Hits	132	Target Neighborhood Hits	90	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
θ value	3.4016e-132 (rank : 5)	NC score	0.963751 (rank : 4)
Query Neighborhood Hits	132	Target Neighborhood Hits	84	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKDRE_HUMAN
θ value	2.12685e-25 (rank : 6)	NC score	0.601621 (rank : 6)
Query Neighborhood Hits	132	Target Neighborhood Hits	64	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
θ value	6.40375e-22 (rank : 7)	NC score	0.574301 (rank : 7)
Query Neighborhood Hits	132	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKD1_HUMAN
θ value	2.7842e-17 (rank : 8)	NC score	0.315724 (rank : 27)
Query Neighborhood Hits	132	Target Neighborhood Hits	387	Shared Neighborhood Hits	9
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

PK1L1_HUMAN
θ value	1.63604e-09 (rank : 9)	NC score	0.470979 (rank : 8)
Query Neighborhood Hits	132	Target Neighborhood Hits	140	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

SC11A_HUMAN
θ value	1.99992e-07 (rank : 10)	NC score	0.318730 (rank : 26)
Query Neighborhood Hits	132	Target Neighborhood Hits	111	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

TRPC3_HUMAN
θ value	7.59969e-07 (rank : 11)	NC score	0.252901 (rank : 47)
Query Neighborhood Hits	132	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

CAC1C_MOUSE
θ value	9.92553e-07 (rank : 12)	NC score	0.357536 (rank : 12)
Query Neighborhood Hits	132	Target Neighborhood Hits	130	Shared Neighborhood Hits	37
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1F_HUMAN
θ value	9.92553e-07 (rank : 13)	NC score	0.358209 (rank : 11)
Query Neighborhood Hits	132	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

MCLN2_MOUSE
θ value	9.92553e-07 (rank : 14)	NC score	0.360002 (rank : 10)
Query Neighborhood Hits	132	Target Neighborhood Hits	31	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN2_HUMAN
θ value	1.29631e-06 (rank : 15)	NC score	0.352623 (rank : 16)
Query Neighborhood Hits	132	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

TRPC3_MOUSE
θ value	1.69304e-06 (rank : 16)	NC score	0.254861 (rank : 46)
Query Neighborhood Hits	132	Target Neighborhood Hits	131	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

CAC1C_HUMAN
θ value	2.88788e-06 (rank : 17)	NC score	0.355677 (rank : 13)
Query Neighborhood Hits	132	Target Neighborhood Hits	158	Shared Neighborhood Hits	38
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

MCLN3_MOUSE
θ value	3.77169e-06 (rank : 18)	NC score	0.346492 (rank : 20)
Query Neighborhood Hits	132	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

CAC1F_MOUSE
θ value	4.92598e-06 (rank : 19)	NC score	0.361301 (rank : 9)
Query Neighborhood Hits	132	Target Neighborhood Hits	142	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_HUMAN
θ value	4.92598e-06 (rank : 20)	NC score	0.342728 (rank : 21)
Query Neighborhood Hits	132	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1E_HUMAN
θ value	1.43324e-05 (rank : 21)	NC score	0.354260 (rank : 15)
Query Neighborhood Hits	132	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	1.87187e-05 (rank : 22)	NC score	0.355071 (rank : 14)
Query Neighborhood Hits	132	Target Neighborhood Hits	167	Shared Neighborhood Hits	42
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1I_HUMAN
θ value	3.19293e-05 (rank : 23)	NC score	0.312251 (rank : 29)
Query Neighborhood Hits	132	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1S_MOUSE
θ value	3.19293e-05 (rank : 24)	NC score	0.340281 (rank : 23)
Query Neighborhood Hits	132	Target Neighborhood Hits	98	Shared Neighborhood Hits	35
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

MCLN3_HUMAN
θ value	3.19293e-05 (rank : 25)	NC score	0.347862 (rank : 18)
Query Neighborhood Hits	132	Target Neighborhood Hits	26	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

CAC1B_HUMAN
θ value	5.44631e-05 (rank : 26)	NC score	0.351437 (rank : 17)
Query Neighborhood Hits	132	Target Neighborhood Hits	257	Shared Neighborhood Hits	49
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1B_MOUSE
θ value	5.44631e-05 (rank : 27)	NC score	0.342641 (rank : 22)
Query Neighborhood Hits	132	Target Neighborhood Hits	351	Shared Neighborhood Hits	49
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

TRPC7_HUMAN
θ value	7.1131e-05 (rank : 28)	NC score	0.220531 (rank : 53)
Query Neighborhood Hits	132	Target Neighborhood Hits	123	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC7_MOUSE
θ value	7.1131e-05 (rank : 29)	NC score	0.220906 (rank : 52)
Query Neighborhood Hits	132	Target Neighborhood Hits	114	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

CAC1D_HUMAN
θ value	9.29e-05 (rank : 30)	NC score	0.347683 (rank : 19)
Query Neighborhood Hits	132	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1A_HUMAN
θ value	0.000158464 (rank : 31)	NC score	0.327045 (rank : 25)
Query Neighborhood Hits	132	Target Neighborhood Hits	387	Shared Neighborhood Hits	48
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_MOUSE
θ value	0.000158464 (rank : 32)	NC score	0.329498 (rank : 24)
Query Neighborhood Hits	132	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

TRPA1_HUMAN
θ value	0.000158464 (rank : 33)	NC score	0.121080 (rank : 71)
Query Neighborhood Hits	132	Target Neighborhood Hits	339	Shared Neighborhood Hits	29
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

TRPC4_HUMAN
θ value	0.000270298 (rank : 34)	NC score	0.238027 (rank : 48)
Query Neighborhood Hits	132	Target Neighborhood Hits	140	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	0.000270298 (rank : 35)	NC score	0.237641 (rank : 49)
Query Neighborhood Hits	132	Target Neighborhood Hits	141	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPC6_HUMAN
θ value	0.000270298 (rank : 36)	NC score	0.233716 (rank : 51)
Query Neighborhood Hits	132	Target Neighborhood Hits	171	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC6_MOUSE
θ value	0.000270298 (rank : 37)	NC score	0.234518 (rank : 50)
Query Neighborhood Hits	132	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

MCLN1_HUMAN
θ value	0.00035302 (rank : 38)	NC score	0.312899 (rank : 28)
Query Neighborhood Hits	132	Target Neighborhood Hits	26	Shared Neighborhood Hits	17
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

SCN5A_HUMAN
θ value	0.00035302 (rank : 39)	NC score	0.309196 (rank : 30)
Query Neighborhood Hits	132	Target Neighborhood Hits	145	Shared Neighborhood Hits	44
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

TRPM7_HUMAN
θ value	0.000786445 (rank : 40)	NC score	0.138072 (rank : 66)
Query Neighborhood Hits	132	Target Neighborhood Hits	104	Shared Neighborhood Hits	30
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPM7_MOUSE
θ value	0.000786445 (rank : 41)	NC score	0.141675 (rank : 64)
Query Neighborhood Hits	132	Target Neighborhood Hits	113	Shared Neighborhood Hits	32
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

MCLN1_MOUSE
θ value	0.00102713 (rank : 42)	NC score	0.308039 (rank : 31)
Query Neighborhood Hits	132	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

TRPV5_MOUSE
θ value	0.00134147 (rank : 43)	NC score	0.168057 (rank : 58)
Query Neighborhood Hits	132	Target Neighborhood Hits	278	Shared Neighborhood Hits	33
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPA1_MOUSE
θ value	0.00228821 (rank : 44)	NC score	0.113459 (rank : 72)
Query Neighborhood Hits	132	Target Neighborhood Hits	343	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

SCN1A_HUMAN
θ value	0.00665767 (rank : 45)	NC score	0.282681 (rank : 37)
Query Neighborhood Hits	132	Target Neighborhood Hits	148	Shared Neighborhood Hits	47
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0.00665767 (rank : 46)	NC score	0.282374 (rank : 38)
Query Neighborhood Hits	132	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

TRPV6_HUMAN
θ value	0.00869519 (rank : 47)	NC score	0.132505 (rank : 67)
Query Neighborhood Hits	132	Target Neighborhood Hits	262	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

SCN9A_HUMAN
θ value	0.0113563 (rank : 48)	NC score	0.285318 (rank : 34)
Query Neighborhood Hits	132	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN3A_HUMAN
θ value	0.0193708 (rank : 49)	NC score	0.280660 (rank : 40)
Query Neighborhood Hits	132	Target Neighborhood Hits	115	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

TRPV3_HUMAN
θ value	0.0193708 (rank : 50)	NC score	0.182617 (rank : 56)
Query Neighborhood Hits	132	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV5_HUMAN
θ value	0.0193708 (rank : 51)	NC score	0.140644 (rank : 65)
Query Neighborhood Hits	132	Target Neighborhood Hits	261	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV6_MOUSE
θ value	0.0252991 (rank : 52)	NC score	0.123338 (rank : 70)
Query Neighborhood Hits	132	Target Neighborhood Hits	284	Shared Neighborhood Hits	32
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

SCN4A_HUMAN
θ value	0.0330416 (rank : 53)	NC score	0.281953 (rank : 39)
Query Neighborhood Hits	132	Target Neighborhood Hits	133	Shared Neighborhood Hits	43
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

CAC1G_HUMAN
θ value	0.0431538 (rank : 54)	NC score	0.283570 (rank : 36)
Query Neighborhood Hits	132	Target Neighborhood Hits	587	Shared Neighborhood Hits	43
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

TRPV3_MOUSE
θ value	0.0431538 (rank : 55)	NC score	0.167036 (rank : 59)
Query Neighborhood Hits	132	Target Neighborhood Hits	188	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

SC11A_MOUSE
θ value	0.0563607 (rank : 56)	NC score	0.292135 (rank : 32)
Query Neighborhood Hits	132	Target Neighborhood Hits	116	Shared Neighborhood Hits	47
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN8A_HUMAN
θ value	0.0736092 (rank : 57)	NC score	0.273156 (rank : 42)
Query Neighborhood Hits	132	Target Neighborhood Hits	135	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	0.0736092 (rank : 58)	NC score	0.272706 (rank : 43)
Query Neighborhood Hits	132	Target Neighborhood Hits	136	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1H_HUMAN
θ value	0.0961366 (rank : 59)	NC score	0.274069 (rank : 41)
Query Neighborhood Hits	132	Target Neighborhood Hits	307	Shared Neighborhood Hits	42
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

TRPV4_HUMAN
θ value	0.0961366 (rank : 60)	NC score	0.152224 (rank : 62)
Query Neighborhood Hits	132	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	0.125558 (rank : 61)	NC score	0.151087 (rank : 63)
Query Neighborhood Hits	132	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

SCN7A_HUMAN
θ value	0.163984 (rank : 62)	NC score	0.267650 (rank : 45)
Query Neighborhood Hits	132	Target Neighborhood Hits	135	Shared Neighborhood Hits	46
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

CAC1H_MOUSE
θ value	0.21417 (rank : 63)	NC score	0.269835 (rank : 44)
Query Neighborhood Hits	132	Target Neighborhood Hits	230	Shared Neighborhood Hits	38
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CE290_HUMAN
θ value	0.279714 (rank : 64)	NC score	0.034438 (rank : 86)
Query Neighborhood Hits	132	Target Neighborhood Hits	1553	Shared Neighborhood Hits	48
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

NUMA1_HUMAN
θ value	0.279714 (rank : 65)	NC score	0.030429 (rank : 91)
Query Neighborhood Hits	132	Target Neighborhood Hits	1523	Shared Neighborhood Hits	47
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

SC10A_HUMAN
θ value	0.279714 (rank : 66)	NC score	0.286213 (rank : 33)
Query Neighborhood Hits	132	Target Neighborhood Hits	116	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

TRPC5_HUMAN
θ value	0.279714 (rank : 67)	NC score	0.202660 (rank : 54)
Query Neighborhood Hits	132	Target Neighborhood Hits	122	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
θ value	0.279714 (rank : 68)	NC score	0.202543 (rank : 55)
Query Neighborhood Hits	132	Target Neighborhood Hits	124	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

CD2AP_HUMAN
θ value	0.365318 (rank : 69)	NC score	0.016246 (rank : 125)
Query Neighborhood Hits	132	Target Neighborhood Hits	315	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

BICD2_HUMAN
θ value	0.47712 (rank : 70)	NC score	0.035606 (rank : 84)
Query Neighborhood Hits	132	Target Neighborhood Hits	856	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
θ value	0.47712 (rank : 71)	NC score	0.035856 (rank : 83)
Query Neighborhood Hits	132	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

TRPM8_MOUSE
θ value	0.47712 (rank : 72)	NC score	0.124972 (rank : 68)
Query Neighborhood Hits	132	Target Neighborhood Hits	58	Shared Neighborhood Hits	34
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

OFD1_HUMAN
θ value	0.62314 (rank : 73)	NC score	0.035235 (rank : 85)
Query Neighborhood Hits	132	Target Neighborhood Hits	753	Shared Neighborhood Hits	37
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

SC10A_MOUSE
θ value	0.62314 (rank : 74)	NC score	0.284783 (rank : 35)
Query Neighborhood Hits	132	Target Neighborhood Hits	107	Shared Neighborhood Hits	48
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

TLN1_HUMAN
θ value	0.62314 (rank : 75)	NC score	0.025650 (rank : 102)
Query Neighborhood Hits	132	Target Neighborhood Hits	218	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TRPM8_HUMAN
θ value	0.62314 (rank : 76)	NC score	0.124195 (rank : 69)
Query Neighborhood Hits	132	Target Neighborhood Hits	65	Shared Neighborhood Hits	36
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

REST_MOUSE
θ value	0.813845 (rank : 77)	NC score	0.026235 (rank : 98)
Query Neighborhood Hits	132	Target Neighborhood Hits	1506	Shared Neighborhood Hits	44
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

TLN1_MOUSE
θ value	0.813845 (rank : 78)	NC score	0.025030 (rank : 103)
Query Neighborhood Hits	132	Target Neighborhood Hits	213	Shared Neighborhood Hits	6
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

CNTRB_MOUSE
θ value	1.06291 (rank : 79)	NC score	0.031295 (rank : 89)
Query Neighborhood Hits	132	Target Neighborhood Hits	1029	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

GRAP1_MOUSE
θ value	1.06291 (rank : 80)	NC score	0.025749 (rank : 101)
Query Neighborhood Hits	132	Target Neighborhood Hits	1234	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

MYH10_HUMAN
θ value	1.06291 (rank : 81)	NC score	0.023827 (rank : 106)
Query Neighborhood Hits	132	Target Neighborhood Hits	1620	Shared Neighborhood Hits	46
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

RAD50_MOUSE
θ value	1.06291 (rank : 82)	NC score	0.033620 (rank : 87)
Query Neighborhood Hits	132	Target Neighborhood Hits	1366	Shared Neighborhood Hits	41
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

ERCC5_MOUSE
θ value	1.38821 (rank : 83)	NC score	0.023816 (rank : 107)
Query Neighborhood Hits	132	Target Neighborhood Hits	206	Shared Neighborhood Hits	11
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

MYH10_MOUSE
θ value	1.38821 (rank : 84)	NC score	0.023640 (rank : 108)
Query Neighborhood Hits	132	Target Neighborhood Hits	1612	Shared Neighborhood Hits	46
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

WNK4_HUMAN
θ value	1.38821 (rank : 85)	NC score	-0.000512 (rank : 143)
Query Neighborhood Hits	132	Target Neighborhood Hits	1043	Shared Neighborhood Hits	6
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

CCD39_HUMAN
θ value	1.81305 (rank : 86)	NC score	0.028777 (rank : 93)
Query Neighborhood Hits	132	Target Neighborhood Hits	868	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD46_HUMAN
θ value	1.81305 (rank : 87)	NC score	0.026014 (rank : 100)
Query Neighborhood Hits	132	Target Neighborhood Hits	1430	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

LETM1_HUMAN
θ value	1.81305 (rank : 88)	NC score	0.030054 (rank : 92)
Query Neighborhood Hits	132	Target Neighborhood Hits	338	Shared Neighborhood Hits	29
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

NIN_HUMAN
θ value	1.81305 (rank : 89)	NC score	0.030531 (rank : 90)
Query Neighborhood Hits	132	Target Neighborhood Hits	1416	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

SPIB_HUMAN
θ value	1.81305 (rank : 90)	NC score	0.015380 (rank : 126)
Query Neighborhood Hits	132	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q01892, Q15359	Gene names	SPIB
Domain Architecture
Description	Transcription factor Spi-B.

CALB2_MOUSE
θ value	2.36792 (rank : 91)	NC score	0.050738 (rank : 82)
Query Neighborhood Hits	132	Target Neighborhood Hits	141	Shared Neighborhood Hits	12
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

CF060_HUMAN
θ value	2.36792 (rank : 92)	NC score	0.026554 (rank : 97)
Query Neighborhood Hits	132	Target Neighborhood Hits	1270	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

EPN1_HUMAN
θ value	2.36792 (rank : 93)	NC score	0.011911 (rank : 127)
Query Neighborhood Hits	132	Target Neighborhood Hits	206	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

GOGA5_MOUSE
θ value	2.36792 (rank : 94)	NC score	0.023281 (rank : 109)
Query Neighborhood Hits	132	Target Neighborhood Hits	1434	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

SNX23_HUMAN
θ value	2.36792 (rank : 95)	NC score	0.016514 (rank : 123)
Query Neighborhood Hits	132	Target Neighborhood Hits	944	Shared Neighborhood Hits	37
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

KCNH3_HUMAN
θ value	3.0926 (rank : 96)	NC score	0.010698 (rank : 129)
Query Neighborhood Hits	132	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

MRP9_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.010590 (rank : 130)
Query Neighborhood Hits	132	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J65, Q49AL2, Q8TAF0, Q8TEY2	Gene names	ABCC12, MRP9
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 9 (ATP-binding cassette transporter sub-family C member 12).

MYH13_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.022755 (rank : 111)
Query Neighborhood Hits	132	Target Neighborhood Hits	1504	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PLEC1_HUMAN
θ value	3.0926 (rank : 99)	NC score	0.019434 (rank : 121)
Query Neighborhood Hits	132	Target Neighborhood Hits	1326	Shared Neighborhood Hits	44
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

SF3A2_MOUSE
θ value	3.0926 (rank : 100)	NC score	0.016460 (rank : 124)
Query Neighborhood Hits	132	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

TPR_HUMAN
θ value	3.0926 (rank : 101)	NC score	0.024635 (rank : 104)
Query Neighborhood Hits	132	Target Neighborhood Hits	1921	Shared Neighborhood Hits	52
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TRHY_HUMAN
θ value	3.0926 (rank : 102)	NC score	0.026129 (rank : 99)
Query Neighborhood Hits	132	Target Neighborhood Hits	1385	Shared Neighborhood Hits	44
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

KCNH3_MOUSE
θ value	4.03905 (rank : 103)	NC score	0.010384 (rank : 131)
Query Neighborhood Hits	132	Target Neighborhood Hits	133	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

MYH11_HUMAN
θ value	4.03905 (rank : 104)	NC score	0.022609 (rank : 112)
Query Neighborhood Hits	132	Target Neighborhood Hits	1806	Shared Neighborhood Hits	45
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

STMN1_HUMAN
θ value	4.03905 (rank : 105)	NC score	0.019854 (rank : 120)
Query Neighborhood Hits	132	Target Neighborhood Hits	554	Shared Neighborhood Hits	32
SwissProt Accessions	P16949	Gene names	STMN1, LAP18, OP18
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Protein Pr22).

AKAP9_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.027827 (rank : 95)
Query Neighborhood Hits	132	Target Neighborhood Hits	1710	Shared Neighborhood Hits	48
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

DSCL1_HUMAN
θ value	5.27518 (rank : 107)	NC score	0.000296 (rank : 142)
Query Neighborhood Hits	132	Target Neighborhood Hits	589	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

FA50A_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.022403 (rank : 113)
Query Neighborhood Hits	132	Target Neighborhood Hits	264	Shared Neighborhood Hits	28
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

MYH11_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.022287 (rank : 114)
Query Neighborhood Hits	132	Target Neighborhood Hits	1777	Shared Neighborhood Hits	44
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PHLB2_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.020420 (rank : 119)
Query Neighborhood Hits	132	Target Neighborhood Hits	1016	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

RAD50_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.033549 (rank : 88)
Query Neighborhood Hits	132	Target Neighborhood Hits	1317	Shared Neighborhood Hits	42
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

ROCK2_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.006433 (rank : 137)
Query Neighborhood Hits	132	Target Neighborhood Hits	2073	Shared Neighborhood Hits	44
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SNX1_MOUSE
θ value	5.27518 (rank : 113)	NC score	0.009187 (rank : 134)
Query Neighborhood Hits	132	Target Neighborhood Hits	157	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV80, Q9EQZ9	Gene names	Snx1
Domain Architecture
Description	Sorting nexin-1.

CALL3_HUMAN
θ value	6.88961 (rank : 114)	NC score	0.002407 (rank : 141)
Query Neighborhood Hits	132	Target Neighborhood Hits	225	Shared Neighborhood Hits	4
SwissProt Accessions	P27482	Gene names	CALML3
Domain Architecture
Description	Calmodulin-like protein 3 (Calmodulin-related protein NB-1) (CaM-like protein) (CLP).

GOGA4_MOUSE
θ value	6.88961 (rank : 115)	NC score	0.022893 (rank : 110)
Query Neighborhood Hits	132	Target Neighborhood Hits	1939	Shared Neighborhood Hits	46
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

IRX3_MOUSE
θ value	6.88961 (rank : 116)	NC score	0.004644 (rank : 139)
Query Neighborhood Hits	132	Target Neighborhood Hits	303	Shared Neighborhood Hits	3
SwissProt Accessions	P81067	Gene names	Irx3, Irxb1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-3 (Iroquois homeobox protein 3) (Homeodomain protein IRXB1).

LAMB3_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.006676 (rank : 136)
Query Neighborhood Hits	132	Target Neighborhood Hits	461	Shared Neighborhood Hits	25
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

MYH2_HUMAN
θ value	6.88961 (rank : 118)	NC score	0.021383 (rank : 117)
Query Neighborhood Hits	132	Target Neighborhood Hits	1491	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

RPGR1_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.026884 (rank : 96)
Query Neighborhood Hits	132	Target Neighborhood Hits	578	Shared Neighborhood Hits	36
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

STMN1_MOUSE
θ value	6.88961 (rank : 120)	NC score	0.018308 (rank : 122)
Query Neighborhood Hits	132	Target Neighborhood Hits	560	Shared Neighborhood Hits	32
SwissProt Accessions	P54227	Gene names	Stmn1, Lag, Lap18, Pr22
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Pr22 protein) (Leukemia-associated gene protein).

TRPM3_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.091896 (rank : 78)
Query Neighborhood Hits	132	Target Neighborhood Hits	121	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

TTP_MOUSE
θ value	6.88961 (rank : 122)	NC score	0.009563 (rank : 133)
Query Neighborhood Hits	132	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	P22893, P11520	Gene names	Zfp36, Tis11, Tis11a
Domain Architecture
Description	Tristetraproline (TTP) (Zinc finger protein 36) (Zfp-36) (TIS11A protein) (TIS11) (Growth factor-inducible nuclear protein NUP475) (TPA-induced sequence 11).

ARY3_MOUSE
θ value	8.99809 (rank : 123)	NC score	0.009681 (rank : 132)
Query Neighborhood Hits	132	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P50296	Gene names	Nat3, Aac3
Domain Architecture
Description	Arylamine N-acetyltransferase 3 (EC 2.3.1.5) (Arylamide acetylase 3) (N-acetyltransferase type 3) (NAT-3).

COIA1_HUMAN
θ value	8.99809 (rank : 124)	NC score	0.005369 (rank : 138)
Query Neighborhood Hits	132	Target Neighborhood Hits	447	Shared Neighborhood Hits	6
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

COIA1_MOUSE
θ value	8.99809 (rank : 125)	NC score	0.003463 (rank : 140)
Query Neighborhood Hits	132	Target Neighborhood Hits	481	Shared Neighborhood Hits	4
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

MYH3_HUMAN
θ value	8.99809 (rank : 126)	NC score	0.021395 (rank : 116)
Query Neighborhood Hits	132	Target Neighborhood Hits	1660	Shared Neighborhood Hits	44
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH9_HUMAN
θ value	8.99809 (rank : 127)	NC score	0.021832 (rank : 115)
Query Neighborhood Hits	132	Target Neighborhood Hits	1762	Shared Neighborhood Hits	46
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NARGL_HUMAN
θ value	8.99809 (rank : 128)	NC score	0.008236 (rank : 135)
Query Neighborhood Hits	132	Target Neighborhood Hits	222	Shared Neighborhood Hits	17
SwissProt Accessions	Q6N069, Q5VSP9, Q6P2D5, Q8N5J3, Q8N870	Gene names	NARG1L, NAT2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

NIN_MOUSE
θ value	8.99809 (rank : 129)	NC score	0.027877 (rank : 94)
Query Neighborhood Hits	132	Target Neighborhood Hits	1376	Shared Neighborhood Hits	50
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

RPGR1_MOUSE
θ value	8.99809 (rank : 130)	NC score	0.021156 (rank : 118)
Query Neighborhood Hits	132	Target Neighborhood Hits	713	Shared Neighborhood Hits	30
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SF3A2_HUMAN
θ value	8.99809 (rank : 131)	NC score	0.011877 (rank : 128)
Query Neighborhood Hits	132	Target Neighborhood Hits	263	Shared Neighborhood Hits	3
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

TMF1_HUMAN
θ value	8.99809 (rank : 132)	NC score	0.024115 (rank : 105)
Query Neighborhood Hits	132	Target Neighborhood Hits	987	Shared Neighborhood Hits	39
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

TRPC1_HUMAN
θ value	θ > 10 (rank : 133)	NC score	0.159445 (rank : 61)
Query Neighborhood Hits	132	Target Neighborhood Hits	91	Shared Neighborhood Hits	34
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	θ > 10 (rank : 134)	NC score	0.159548 (rank : 60)
Query Neighborhood Hits	132	Target Neighborhood Hits	87	Shared Neighborhood Hits	34
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC2_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.168088 (rank : 57)
Query Neighborhood Hits	132	Target Neighborhood Hits	84	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

TRPM2_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.093189 (rank : 76)
Query Neighborhood Hits	132	Target Neighborhood Hits	64	Shared Neighborhood Hits	30
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM2_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.091852 (rank : 79)
Query Neighborhood Hits	132	Target Neighborhood Hits	61	Shared Neighborhood Hits	32
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM6_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.092033 (rank : 77)
Query Neighborhood Hits	132	Target Neighborhood Hits	91	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM6_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.093806 (rank : 75)
Query Neighborhood Hits	132	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPV1_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.099083 (rank : 73)
Query Neighborhood Hits	132	Target Neighborhood Hits	184	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.094341 (rank : 74)
Query Neighborhood Hits	132	Target Neighborhood Hits	189	Shared Neighborhood Hits	32
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV2_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.080817 (rank : 81)
Query Neighborhood Hits	132	Target Neighborhood Hits	130	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.081141 (rank : 80)
Query Neighborhood Hits	132	Target Neighborhood Hits	111	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

Hits sorted by NC score

PK2L1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	132	Target Neighborhood Hits	132	Shared Neighborhood Hits	132
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_HUMAN
NC score	0.969112 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	132	Target Neighborhood Hits	105	Shared Neighborhood Hits	69
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PKD2_MOUSE
NC score	0.967132 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	132	Target Neighborhood Hits	99	Shared Neighborhood Hits	66
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PK2L2_MOUSE
NC score	0.963751 (rank : 4)	θ value	3.4016e-132 (rank : 5)
Query Neighborhood Hits	132	Target Neighborhood Hits	84	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_HUMAN
NC score	0.961548 (rank : 5)	θ value	1.42583e-138 (rank : 4)
Query Neighborhood Hits	132	Target Neighborhood Hits	90	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKDRE_HUMAN
NC score	0.601621 (rank : 6)	θ value	2.12685e-25 (rank : 6)
Query Neighborhood Hits	132	Target Neighborhood Hits	64	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
NC score	0.574301 (rank : 7)	θ value	6.40375e-22 (rank : 7)
Query Neighborhood Hits	132	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PK1L1_HUMAN
NC score	0.470979 (rank : 8)	θ value	1.63604e-09 (rank : 9)
Query Neighborhood Hits	132	Target Neighborhood Hits	140	Shared Neighborhood Hits	12
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

CAC1F_MOUSE
NC score	0.361301 (rank : 9)	θ value	4.92598e-06 (rank : 19)
Query Neighborhood Hits	132	Target Neighborhood Hits	142	Shared Neighborhood Hits	38
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

MCLN2_MOUSE
NC score	0.360002 (rank : 10)	θ value	9.92553e-07 (rank : 14)
Query Neighborhood Hits	132	Target Neighborhood Hits	31	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

CAC1F_HUMAN
NC score	0.358209 (rank : 11)	θ value	9.92553e-07 (rank : 13)
Query Neighborhood Hits	132	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.357536 (rank : 12)	θ value	9.92553e-07 (rank : 12)
Query Neighborhood Hits	132	Target Neighborhood Hits	130	Shared Neighborhood Hits	37
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.355677 (rank : 13)	θ value	2.88788e-06 (rank : 17)
Query Neighborhood Hits	132	Target Neighborhood Hits	158	Shared Neighborhood Hits	38
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1E_MOUSE
NC score	0.355071 (rank : 14)	θ value	1.87187e-05 (rank : 22)
Query Neighborhood Hits	132	Target Neighborhood Hits	167	Shared Neighborhood Hits	42
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.354260 (rank : 15)	θ value	1.43324e-05 (rank : 21)
Query Neighborhood Hits	132	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

MCLN2_HUMAN
NC score	0.352623 (rank : 16)	θ value	1.29631e-06 (rank : 15)
Query Neighborhood Hits	132	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

CAC1B_HUMAN
NC score	0.351437 (rank : 17)	θ value	5.44631e-05 (rank : 26)
Query Neighborhood Hits	132	Target Neighborhood Hits	257	Shared Neighborhood Hits	49
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

MCLN3_HUMAN
NC score	0.347862 (rank : 18)	θ value	3.19293e-05 (rank : 25)
Query Neighborhood Hits	132	Target Neighborhood Hits	26	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

CAC1D_HUMAN
NC score	0.347683 (rank : 19)	θ value	9.29e-05 (rank : 30)
Query Neighborhood Hits	132	Target Neighborhood Hits	118	Shared Neighborhood Hits	38
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

MCLN3_MOUSE
NC score	0.346492 (rank : 20)	θ value	3.77169e-06 (rank : 18)
Query Neighborhood Hits	132	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

CAC1S_HUMAN
NC score	0.342728 (rank : 21)	θ value	4.92598e-06 (rank : 20)
Query Neighborhood Hits	132	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_MOUSE
NC score	0.342641 (rank : 22)	θ value	5.44631e-05 (rank : 27)
Query Neighborhood Hits	132	Target Neighborhood Hits	351	Shared Neighborhood Hits	49
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_MOUSE
NC score	0.340281 (rank : 23)	θ value	3.19293e-05 (rank : 24)
Query Neighborhood Hits	132	Target Neighborhood Hits	98	Shared Neighborhood Hits	35
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1A_MOUSE
NC score	0.329498 (rank : 24)	θ value	0.000158464 (rank : 32)
Query Neighborhood Hits	132	Target Neighborhood Hits	267	Shared Neighborhood Hits	45
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_HUMAN
NC score	0.327045 (rank : 25)	θ value	0.000158464 (rank : 31)
Query Neighborhood Hits	132	Target Neighborhood Hits	387	Shared Neighborhood Hits	48
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

SC11A_HUMAN
NC score	0.318730 (rank : 26)	θ value	1.99992e-07 (rank : 10)
Query Neighborhood Hits	132	Target Neighborhood Hits	111	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

PKD1_HUMAN
NC score	0.315724 (rank : 27)	θ value	2.7842e-17 (rank : 8)
Query Neighborhood Hits	132	Target Neighborhood Hits	387	Shared Neighborhood Hits	9
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

MCLN1_HUMAN
NC score	0.312899 (rank : 28)	θ value	0.00035302 (rank : 38)
Query Neighborhood Hits	132	Target Neighborhood Hits	26	Shared Neighborhood Hits	17
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

CAC1I_HUMAN
NC score	0.312251 (rank : 29)	θ value	3.19293e-05 (rank : 23)
Query Neighborhood Hits	132	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

SCN5A_HUMAN
NC score	0.309196 (rank : 30)	θ value	0.00035302 (rank : 39)
Query Neighborhood Hits	132	Target Neighborhood Hits	145	Shared Neighborhood Hits	44
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

MCLN1_MOUSE
NC score	0.308039 (rank : 31)	θ value	0.00102713 (rank : 42)
Query Neighborhood Hits	132	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

SC11A_MOUSE
NC score	0.292135 (rank : 32)	θ value	0.0563607 (rank : 56)
Query Neighborhood Hits	132	Target Neighborhood Hits	116	Shared Neighborhood Hits	47
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC10A_HUMAN
NC score	0.286213 (rank : 33)	θ value	0.279714 (rank : 66)
Query Neighborhood Hits	132	Target Neighborhood Hits	116	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN9A_HUMAN
NC score	0.285318 (rank : 34)	θ value	0.0113563 (rank : 48)
Query Neighborhood Hits	132	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SC10A_MOUSE
NC score	0.284783 (rank : 35)	θ value	0.62314 (rank : 74)
Query Neighborhood Hits	132	Target Neighborhood Hits	107	Shared Neighborhood Hits	48
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

CAC1G_HUMAN
NC score	0.283570 (rank : 36)	θ value	0.0431538 (rank : 54)
Query Neighborhood Hits	132	Target Neighborhood Hits	587	Shared Neighborhood Hits	43
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN1A_HUMAN
NC score	0.282681 (rank : 37)	θ value	0.00665767 (rank : 45)
Query Neighborhood Hits	132	Target Neighborhood Hits	148	Shared Neighborhood Hits	47
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
NC score	0.282374 (rank : 38)	θ value	0.00665767 (rank : 46)
Query Neighborhood Hits	132	Target Neighborhood Hits	157	Shared Neighborhood Hits	45
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN4A_HUMAN
NC score	0.281953 (rank : 39)	θ value	0.0330416 (rank : 53)
Query Neighborhood Hits	132	Target Neighborhood Hits	133	Shared Neighborhood Hits	43
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN3A_HUMAN
NC score	0.280660 (rank : 40)	θ value	0.0193708 (rank : 49)
Query Neighborhood Hits	132	Target Neighborhood Hits	115	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

CAC1H_HUMAN
NC score	0.274069 (rank : 41)	θ value	0.0961366 (rank : 59)
Query Neighborhood Hits	132	Target Neighborhood Hits	307	Shared Neighborhood Hits	42
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

SCN8A_HUMAN
NC score	0.273156 (rank : 42)	θ value	0.0736092 (rank : 57)
Query Neighborhood Hits	132	Target Neighborhood Hits	135	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
NC score	0.272706 (rank : 43)	θ value	0.0736092 (rank : 58)
Query Neighborhood Hits	132	Target Neighborhood Hits	136	Shared Neighborhood Hits	44
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1H_MOUSE
NC score	0.269835 (rank : 44)	θ value	0.21417 (rank : 63)
Query Neighborhood Hits	132	Target Neighborhood Hits	230	Shared Neighborhood Hits	38
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

SCN7A_HUMAN
NC score	0.267650 (rank : 45)	θ value	0.163984 (rank : 62)
Query Neighborhood Hits	132	Target Neighborhood Hits	135	Shared Neighborhood Hits	46
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

TRPC3_MOUSE
NC score	0.254861 (rank : 46)	θ value	1.69304e-06 (rank : 16)
Query Neighborhood Hits	132	Target Neighborhood Hits	131	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

TRPC3_HUMAN
NC score	0.252901 (rank : 47)	θ value	7.59969e-07 (rank : 11)
Query Neighborhood Hits	132	Target Neighborhood Hits	137	Shared Neighborhood Hits	31
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPC4_HUMAN
NC score	0.238027 (rank : 48)	θ value	0.000270298 (rank : 34)
Query Neighborhood Hits	132	Target Neighborhood Hits	140	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.237641 (rank : 49)	θ value	0.000270298 (rank : 35)
Query Neighborhood Hits	132	Target Neighborhood Hits	141	Shared Neighborhood Hits	42
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPC6_MOUSE
NC score	0.234518 (rank : 50)	θ value	0.000270298 (rank : 37)
Query Neighborhood Hits	132	Target Neighborhood Hits	171	Shared Neighborhood Hits	35
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPC6_HUMAN
NC score	0.233716 (rank : 51)	θ value	0.000270298 (rank : 36)
Query Neighborhood Hits	132	Target Neighborhood Hits	171	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC7_MOUSE
NC score	0.220906 (rank : 52)	θ value	7.1131e-05 (rank : 29)
Query Neighborhood Hits	132	Target Neighborhood Hits	114	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPC7_HUMAN
NC score	0.220531 (rank : 53)	θ value	7.1131e-05 (rank : 28)
Query Neighborhood Hits	132	Target Neighborhood Hits	123	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC5_HUMAN
NC score	0.202660 (rank : 54)	θ value	0.279714 (rank : 67)
Query Neighborhood Hits	132	Target Neighborhood Hits	122	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
NC score	0.202543 (rank : 55)	θ value	0.279714 (rank : 68)
Query Neighborhood Hits	132	Target Neighborhood Hits	124	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

TRPV3_HUMAN
NC score	0.182617 (rank : 56)	θ value	0.0193708 (rank : 50)
Query Neighborhood Hits	132	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPC2_MOUSE
NC score	0.168088 (rank : 57)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	132	Target Neighborhood Hits	84	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

TRPV5_MOUSE
NC score	0.168057 (rank : 58)	θ value	0.00134147 (rank : 43)
Query Neighborhood Hits	132	Target Neighborhood Hits	278	Shared Neighborhood Hits	33
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV3_MOUSE
NC score	0.167036 (rank : 59)	θ value	0.0431538 (rank : 55)
Query Neighborhood Hits	132	Target Neighborhood Hits	188	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPC1_MOUSE
NC score	0.159548 (rank : 60)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	132	Target Neighborhood Hits	87	Shared Neighborhood Hits	34
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.159445 (rank : 61)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	132	Target Neighborhood Hits	91	Shared Neighborhood Hits	34
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPV4_HUMAN
NC score	0.152224 (rank : 62)	θ value	0.0961366 (rank : 60)
Query Neighborhood Hits	132	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
NC score	0.151087 (rank : 63)	θ value	0.125558 (rank : 61)
Query Neighborhood Hits	132	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPM7_MOUSE
NC score	0.141675 (rank : 64)	θ value	0.000786445 (rank : 41)
Query Neighborhood Hits	132	Target Neighborhood Hits	113	Shared Neighborhood Hits	32
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

TRPV5_HUMAN
NC score	0.140644 (rank : 65)	θ value	0.0193708 (rank : 51)
Query Neighborhood Hits	132	Target Neighborhood Hits	261	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPM7_HUMAN
NC score	0.138072 (rank : 66)	θ value	0.000786445 (rank : 40)
Query Neighborhood Hits	132	Target Neighborhood Hits	104	Shared Neighborhood Hits	30
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPV6_HUMAN
NC score	0.132505 (rank : 67)	θ value	0.00869519 (rank : 47)
Query Neighborhood Hits	132	Target Neighborhood Hits	262	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TRPM8_MOUSE
NC score	0.124972 (rank : 68)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	132	Target Neighborhood Hits	58	Shared Neighborhood Hits	34
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

TRPM8_HUMAN
NC score	0.124195 (rank : 69)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	132	Target Neighborhood Hits	65	Shared Neighborhood Hits	36
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPV6_MOUSE
NC score	0.123338 (rank : 70)	θ value	0.0252991 (rank : 52)
Query Neighborhood Hits	132	Target Neighborhood Hits	284	Shared Neighborhood Hits	32
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

TRPA1_HUMAN
NC score	0.121080 (rank : 71)	θ value	0.000158464 (rank : 33)
Query Neighborhood Hits	132	Target Neighborhood Hits	339	Shared Neighborhood Hits	29
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

TRPA1_MOUSE
NC score	0.113459 (rank : 72)	θ value	0.00228821 (rank : 44)
Query Neighborhood Hits	132	Target Neighborhood Hits	343	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

TRPV1_HUMAN
NC score	0.099083 (rank : 73)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	132	Target Neighborhood Hits	184	Shared Neighborhood Hits	35
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
NC score	0.094341 (rank : 74)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	132	Target Neighborhood Hits	189	Shared Neighborhood Hits	32
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPM6_MOUSE
NC score	0.093806 (rank : 75)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	132	Target Neighborhood Hits	78	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM2_HUMAN
NC score	0.093189 (rank : 76)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	132	Target Neighborhood Hits	64	Shared Neighborhood Hits	30
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM6_HUMAN
NC score	0.092033 (rank : 77)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	132	Target Neighborhood Hits	91	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM3_HUMAN
NC score	0.091896 (rank : 78)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	132	Target Neighborhood Hits	121	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

TRPM2_MOUSE
NC score	0.091852 (rank : 79)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	132	Target Neighborhood Hits	61	Shared Neighborhood Hits	32
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPV2_MOUSE
NC score	0.081141 (rank : 80)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	132	Target Neighborhood Hits	111	Shared Neighborhood Hits	18
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

TRPV2_HUMAN
NC score	0.080817 (rank : 81)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	132	Target Neighborhood Hits	130	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

CALB2_MOUSE
NC score	0.050738 (rank : 82)	θ value	2.36792 (rank : 91)
Query Neighborhood Hits	132	Target Neighborhood Hits	141	Shared Neighborhood Hits	12
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

BICD2_MOUSE
NC score	0.035856 (rank : 83)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	132	Target Neighborhood Hits	864	Shared Neighborhood Hits	40
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_HUMAN
NC score	0.035606 (rank : 84)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	132	Target Neighborhood Hits	856	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

OFD1_HUMAN
NC score	0.035235 (rank : 85)	θ value	0.62314 (rank : 73)
Query Neighborhood Hits	132	Target Neighborhood Hits	753	Shared Neighborhood Hits	37
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

CE290_HUMAN
NC score	0.034438 (rank : 86)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	132	Target Neighborhood Hits	1553	Shared Neighborhood Hits	48
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

RAD50_MOUSE
NC score	0.033620 (rank : 87)	θ value	1.06291 (rank : 82)
Query Neighborhood Hits	132	Target Neighborhood Hits	1366	Shared Neighborhood Hits	41
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RAD50_HUMAN
NC score	0.033549 (rank : 88)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	132	Target Neighborhood Hits	1317	Shared Neighborhood Hits	42
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

CNTRB_MOUSE
NC score	0.031295 (rank : 89)	θ value	1.06291 (rank : 79)
Query Neighborhood Hits	132	Target Neighborhood Hits	1029	Shared Neighborhood Hits	40
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

NIN_HUMAN
NC score	0.030531 (rank : 90)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	132	Target Neighborhood Hits	1416	Shared Neighborhood Hits	49
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NUMA1_HUMAN
NC score	0.030429 (rank : 91)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	132	Target Neighborhood Hits	1523	Shared Neighborhood Hits	47
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

LETM1_HUMAN
NC score	0.030054 (rank : 92)	θ value	1.81305 (rank : 88)
Query Neighborhood Hits	132	Target Neighborhood Hits	338	Shared Neighborhood Hits	29
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

CCD39_HUMAN
NC score	0.028777 (rank : 93)	θ value	1.81305 (rank : 86)
Query Neighborhood Hits	132	Target Neighborhood Hits	868	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

NIN_MOUSE
NC score	0.027877 (rank : 94)	θ value	8.99809 (rank : 129)
Query Neighborhood Hits	132	Target Neighborhood Hits	1376	Shared Neighborhood Hits	50
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

AKAP9_HUMAN
NC score	0.027827 (rank : 95)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	132	Target Neighborhood Hits	1710	Shared Neighborhood Hits	48
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

RPGR1_HUMAN
NC score	0.026884 (rank : 96)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	132	Target Neighborhood Hits	578	Shared Neighborhood Hits	36
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

CF060_HUMAN
NC score	0.026554 (rank : 97)	θ value	2.36792 (rank : 92)
Query Neighborhood Hits	132	Target Neighborhood Hits	1270	Shared Neighborhood Hits	40
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

REST_MOUSE
NC score	0.026235 (rank : 98)	θ value	0.813845 (rank : 77)
Query Neighborhood Hits	132	Target Neighborhood Hits	1506	Shared Neighborhood Hits	44
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

TRHY_HUMAN
NC score	0.026129 (rank : 99)	θ value	3.0926 (rank : 102)
Query Neighborhood Hits	132	Target Neighborhood Hits	1385	Shared Neighborhood Hits	44
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

CCD46_HUMAN
NC score	0.026014 (rank : 100)	θ value	1.81305 (rank : 87)
Query Neighborhood Hits	132	Target Neighborhood Hits	1430	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

GRAP1_MOUSE
NC score	0.025749 (rank : 101)	θ value	1.06291 (rank : 80)
Query Neighborhood Hits	132	Target Neighborhood Hits	1234	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

TLN1_HUMAN
NC score	0.025650 (rank : 102)	θ value	0.62314 (rank : 75)
Query Neighborhood Hits	132	Target Neighborhood Hits	218	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
NC score	0.025030 (rank : 103)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	132	Target Neighborhood Hits	213	Shared Neighborhood Hits	6
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TPR_HUMAN
NC score	0.024635 (rank : 104)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	132	Target Neighborhood Hits	1921	Shared Neighborhood Hits	52
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TMF1_HUMAN
NC score	0.024115 (rank : 105)	θ value	8.99809 (rank : 132)
Query Neighborhood Hits	132	Target Neighborhood Hits	987	Shared Neighborhood Hits	39
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

MYH10_HUMAN
NC score	0.023827 (rank : 106)	θ value	1.06291 (rank : 81)
Query Neighborhood Hits	132	Target Neighborhood Hits	1620	Shared Neighborhood Hits	46
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

ERCC5_MOUSE
NC score	0.023816 (rank : 107)	θ value	1.38821 (rank : 83)
Query Neighborhood Hits	132	Target Neighborhood Hits	206	Shared Neighborhood Hits	11
SwissProt Accessions	P35689, Q61528, Q64248	Gene names	Ercc5, Ercc-5, Xpg
Domain Architecture
Description	DNA-repair protein complementing XP-G cells homolog (Xeroderma pigmentosum group G-complementing protein homolog) (DNA excision repair protein ERCC-5).

MYH10_MOUSE
NC score	0.023640 (rank : 108)	θ value	1.38821 (rank : 84)
Query Neighborhood Hits	132	Target Neighborhood Hits	1612	Shared Neighborhood Hits	46
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

GOGA5_MOUSE
NC score	0.023281 (rank : 109)	θ value	2.36792 (rank : 94)
Query Neighborhood Hits	132	Target Neighborhood Hits	1434	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

GOGA4_MOUSE
NC score	0.022893 (rank : 110)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	132	Target Neighborhood Hits	1939	Shared Neighborhood Hits	46
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

MYH13_HUMAN
NC score	0.022755 (rank : 111)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	132	Target Neighborhood Hits	1504	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH11_HUMAN
NC score	0.022609 (rank : 112)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	132	Target Neighborhood Hits	1806	Shared Neighborhood Hits	45
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

FA50A_HUMAN
NC score	0.022403 (rank : 113)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	132	Target Neighborhood Hits	264	Shared Neighborhood Hits	28
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

MYH11_MOUSE
NC score	0.022287 (rank : 114)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	132	Target Neighborhood Hits	1777	Shared Neighborhood Hits	44
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH9_HUMAN
NC score	0.021832 (rank : 115)	θ value	8.99809 (rank : 127)
Query Neighborhood Hits	132	Target Neighborhood Hits	1762	Shared Neighborhood Hits	46
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH3_HUMAN
NC score	0.021395 (rank : 116)	θ value	8.99809 (rank : 126)
Query Neighborhood Hits	132	Target Neighborhood Hits	1660	Shared Neighborhood Hits	44
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH2_HUMAN
NC score	0.021383 (rank : 117)	θ value	6.88961 (rank : 118)
Query Neighborhood Hits	132	Target Neighborhood Hits	1491	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

RPGR1_MOUSE
NC score	0.021156 (rank : 118)	θ value	8.99809 (rank : 130)
Query Neighborhood Hits	132	Target Neighborhood Hits	713	Shared Neighborhood Hits	30
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

PHLB2_MOUSE
NC score	0.020420 (rank : 119)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	132	Target Neighborhood Hits	1016	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

STMN1_HUMAN
NC score	0.019854 (rank : 120)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	132	Target Neighborhood Hits	554	Shared Neighborhood Hits	32
SwissProt Accessions	P16949	Gene names	STMN1, LAP18, OP18
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Protein Pr22).

PLEC1_HUMAN
NC score	0.019434 (rank : 121)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	132	Target Neighborhood Hits	1326	Shared Neighborhood Hits	44
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

STMN1_MOUSE
NC score	0.018308 (rank : 122)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	132	Target Neighborhood Hits	560	Shared Neighborhood Hits	32
SwissProt Accessions	P54227	Gene names	Stmn1, Lag, Lap18, Pr22
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Pr22 protein) (Leukemia-associated gene protein).

SNX23_HUMAN
NC score	0.016514 (rank : 123)	θ value	2.36792 (rank : 95)
Query Neighborhood Hits	132	Target Neighborhood Hits	944	Shared Neighborhood Hits	37
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

SF3A2_MOUSE
NC score	0.016460 (rank : 124)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	132	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

CD2AP_HUMAN
NC score	0.016246 (rank : 125)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	132	Target Neighborhood Hits	315	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SPIB_HUMAN
NC score	0.015380 (rank : 126)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	132	Target Neighborhood Hits	60	Shared Neighborhood Hits	2
SwissProt Accessions	Q01892, Q15359	Gene names	SPIB
Domain Architecture
Description	Transcription factor Spi-B.

EPN1_HUMAN
NC score	0.011911 (rank : 127)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	132	Target Neighborhood Hits	206	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6I3, Q86ST3, Q9HA18	Gene names	EPN1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (EH domain-binding mitotic phosphoprotein).

SF3A2_HUMAN
NC score	0.011877 (rank : 128)	θ value	8.99809 (rank : 131)
Query Neighborhood Hits	132	Target Neighborhood Hits	263	Shared Neighborhood Hits	3
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

KCNH3_HUMAN
NC score	0.010698 (rank : 129)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	132	Target Neighborhood Hits	148	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULD8, Q9UQ06	Gene names	KCNH3, KIAA1282
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Brain-specific eag-like channel 1) (BEC1).

MRP9_HUMAN
NC score	0.010590 (rank : 130)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	132	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J65, Q49AL2, Q8TAF0, Q8TEY2	Gene names	ABCC12, MRP9
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 9 (ATP-binding cassette transporter sub-family C member 12).

KCNH3_MOUSE
NC score	0.010384 (rank : 131)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	132	Target Neighborhood Hits	133	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WVJ0	Gene names	Kcnh3, Elk2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 3 (Voltage-gated potassium channel subunit Kv12.2) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (mElk2).

ARY3_MOUSE
NC score	0.009681 (rank : 132)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	132	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	P50296	Gene names	Nat3, Aac3
Domain Architecture
Description	Arylamine N-acetyltransferase 3 (EC 2.3.1.5) (Arylamide acetylase 3) (N-acetyltransferase type 3) (NAT-3).

TTP_MOUSE
NC score	0.009563 (rank : 133)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	132	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	P22893, P11520	Gene names	Zfp36, Tis11, Tis11a
Domain Architecture
Description	Tristetraproline (TTP) (Zinc finger protein 36) (Zfp-36) (TIS11A protein) (TIS11) (Growth factor-inducible nuclear protein NUP475) (TPA-induced sequence 11).

SNX1_MOUSE
NC score	0.009187 (rank : 134)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	132	Target Neighborhood Hits	157	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV80, Q9EQZ9	Gene names	Snx1
Domain Architecture
Description	Sorting nexin-1.

NARGL_HUMAN
NC score	0.008236 (rank : 135)	θ value	8.99809 (rank : 128)
Query Neighborhood Hits	132	Target Neighborhood Hits	222	Shared Neighborhood Hits	17
SwissProt Accessions	Q6N069, Q5VSP9, Q6P2D5, Q8N5J3, Q8N870	Gene names	NARG1L, NAT2
Domain Architecture	No domain graphic available
Description	NMDA receptor-regulated 1-like protein (NARG1-like protein).

LAMB3_HUMAN
NC score	0.006676 (rank : 136)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	132	Target Neighborhood Hits	461	Shared Neighborhood Hits	25
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

ROCK2_HUMAN
NC score	0.006433 (rank : 137)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	132	Target Neighborhood Hits	2073	Shared Neighborhood Hits	44
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

COIA1_HUMAN
NC score	0.005369 (rank : 138)	θ value	8.99809 (rank : 124)
Query Neighborhood Hits	132	Target Neighborhood Hits	447	Shared Neighborhood Hits	6
SwissProt Accessions	P39060, Q9UK38, Q9Y6Q7, Q9Y6Q8	Gene names	COL18A1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

IRX3_MOUSE
NC score	0.004644 (rank : 139)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	132	Target Neighborhood Hits	303	Shared Neighborhood Hits	3
SwissProt Accessions	P81067	Gene names	Irx3, Irxb1
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-3 (Iroquois homeobox protein 3) (Homeodomain protein IRXB1).

COIA1_MOUSE
NC score	0.003463 (rank : 140)	θ value	8.99809 (rank : 125)
Query Neighborhood Hits	132	Target Neighborhood Hits	481	Shared Neighborhood Hits	4
SwissProt Accessions	P39061, Q60672, Q61437, Q62001, Q62002, Q9JK63	Gene names	Col18a1
Domain Architecture
Description	Collagen alpha-1(XVIII) chain precursor [Contains: Endostatin].

CALL3_HUMAN
NC score	0.002407 (rank : 141)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	132	Target Neighborhood Hits	225	Shared Neighborhood Hits	4
SwissProt Accessions	P27482	Gene names	CALML3
Domain Architecture
Description	Calmodulin-like protein 3 (Calmodulin-related protein NB-1) (CaM-like protein) (CLP).

DSCL1_HUMAN
NC score	0.000296 (rank : 142)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	132	Target Neighborhood Hits	589	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

WNK4_HUMAN
NC score	-0.000512 (rank : 143)	θ value	1.38821 (rank : 85)
Query Neighborhood Hits	132	Target Neighborhood Hits	1043	Shared Neighborhood Hits	6
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).