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Network neighborhood for query Sequence : PKD2_HUMAN

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PKD2_HUMAN
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PK2L1_HUMAN
θ value	0 (rank : 1)	NC score	0.969112 (rank : 3)
Query Neighborhood Hits	105	Target Neighborhood Hits	132	Shared Neighborhood Hits	69
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	105	Target Neighborhood Hits	105	Shared Neighborhood Hits	105
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PKD2_MOUSE
θ value	0 (rank : 3)	NC score	0.993030 (rank : 2)
Query Neighborhood Hits	105	Target Neighborhood Hits	99	Shared Neighborhood Hits	79
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PK2L2_HUMAN
θ value	5.99046e-137 (rank : 4)	NC score	0.962148 (rank : 4)
Query Neighborhood Hits	105	Target Neighborhood Hits	90	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
θ value	2.78268e-134 (rank : 5)	NC score	0.961251 (rank : 5)
Query Neighborhood Hits	105	Target Neighborhood Hits	84	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKDRE_HUMAN
θ value	1.5242e-23 (rank : 6)	NC score	0.600242 (rank : 6)
Query Neighborhood Hits	105	Target Neighborhood Hits	64	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKD1_HUMAN
θ value	3.51386e-20 (rank : 7)	NC score	0.325133 (rank : 23)
Query Neighborhood Hits	105	Target Neighborhood Hits	387	Shared Neighborhood Hits	10
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

PKDRE_MOUSE
θ value	2.97466e-19 (rank : 8)	NC score	0.571020 (rank : 7)
Query Neighborhood Hits	105	Target Neighborhood Hits	76	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PK1L1_HUMAN
θ value	1.80466e-16 (rank : 9)	NC score	0.501822 (rank : 8)
Query Neighborhood Hits	105	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

TRPA1_MOUSE
θ value	8.11959e-09 (rank : 10)	NC score	0.130930 (rank : 62)
Query Neighborhood Hits	105	Target Neighborhood Hits	343	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

TRPA1_HUMAN
θ value	1.06045e-08 (rank : 11)	NC score	0.136842 (rank : 61)
Query Neighborhood Hits	105	Target Neighborhood Hits	339	Shared Neighborhood Hits	30
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

CAC1F_MOUSE
θ value	4.0297e-08 (rank : 12)	NC score	0.342516 (rank : 13)
Query Neighborhood Hits	105	Target Neighborhood Hits	142	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

MCLN2_MOUSE
θ value	4.0297e-08 (rank : 13)	NC score	0.379497 (rank : 9)
Query Neighborhood Hits	105	Target Neighborhood Hits	31	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN2_HUMAN
θ value	5.26297e-08 (rank : 14)	NC score	0.373907 (rank : 10)
Query Neighborhood Hits	105	Target Neighborhood Hits	23	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN3_HUMAN
θ value	5.26297e-08 (rank : 15)	NC score	0.369356 (rank : 11)
Query Neighborhood Hits	105	Target Neighborhood Hits	26	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

CAC1C_HUMAN
θ value	8.97725e-08 (rank : 16)	NC score	0.336289 (rank : 16)
Query Neighborhood Hits	105	Target Neighborhood Hits	158	Shared Neighborhood Hits	35
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1F_HUMAN
θ value	1.17247e-07 (rank : 17)	NC score	0.339065 (rank : 14)
Query Neighborhood Hits	105	Target Neighborhood Hits	141	Shared Neighborhood Hits	35
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

MCLN3_MOUSE
θ value	3.41135e-07 (rank : 18)	NC score	0.366455 (rank : 12)
Query Neighborhood Hits	105	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

CAC1C_MOUSE
θ value	4.45536e-07 (rank : 19)	NC score	0.337490 (rank : 15)
Query Neighborhood Hits	105	Target Neighborhood Hits	130	Shared Neighborhood Hits	35
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1B_HUMAN
θ value	2.88788e-06 (rank : 20)	NC score	0.329618 (rank : 21)
Query Neighborhood Hits	105	Target Neighborhood Hits	257	Shared Neighborhood Hits	47
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

SC11A_HUMAN
θ value	8.40245e-06 (rank : 21)	NC score	0.296141 (rank : 29)
Query Neighborhood Hits	105	Target Neighborhood Hits	111	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

CAC1E_MOUSE
θ value	1.87187e-05 (rank : 22)	NC score	0.332170 (rank : 18)
Query Neighborhood Hits	105	Target Neighborhood Hits	167	Shared Neighborhood Hits	42
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1D_HUMAN
θ value	3.19293e-05 (rank : 23)	NC score	0.327781 (rank : 22)
Query Neighborhood Hits	105	Target Neighborhood Hits	118	Shared Neighborhood Hits	37
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

MCLN1_HUMAN
θ value	4.1701e-05 (rank : 24)	NC score	0.334379 (rank : 17)
Query Neighborhood Hits	105	Target Neighborhood Hits	26	Shared Neighborhood Hits	17
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

CAC1E_HUMAN
θ value	5.44631e-05 (rank : 25)	NC score	0.330846 (rank : 19)
Query Neighborhood Hits	105	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1B_MOUSE
θ value	9.29e-05 (rank : 26)	NC score	0.319561 (rank : 25)
Query Neighborhood Hits	105	Target Neighborhood Hits	351	Shared Neighborhood Hits	44
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

MCLN1_MOUSE
θ value	9.29e-05 (rank : 27)	NC score	0.329726 (rank : 20)
Query Neighborhood Hits	105	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

SCN5A_HUMAN
θ value	9.29e-05 (rank : 28)	NC score	0.290354 (rank : 30)
Query Neighborhood Hits	105	Target Neighborhood Hits	145	Shared Neighborhood Hits	43
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

CAC1S_HUMAN
θ value	0.000158464 (rank : 29)	NC score	0.321794 (rank : 24)
Query Neighborhood Hits	105	Target Neighborhood Hits	92	Shared Neighborhood Hits	35
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
θ value	0.000158464 (rank : 30)	NC score	0.319275 (rank : 26)
Query Neighborhood Hits	105	Target Neighborhood Hits	98	Shared Neighborhood Hits	34
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

TRPC3_MOUSE
θ value	0.000158464 (rank : 31)	NC score	0.205095 (rank : 46)
Query Neighborhood Hits	105	Target Neighborhood Hits	131	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

TRPC4_HUMAN
θ value	0.000270298 (rank : 32)	NC score	0.195181 (rank : 48)
Query Neighborhood Hits	105	Target Neighborhood Hits	140	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	0.000270298 (rank : 33)	NC score	0.194962 (rank : 49)
Query Neighborhood Hits	105	Target Neighborhood Hits	141	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPC3_HUMAN
θ value	0.00035302 (rank : 34)	NC score	0.203332 (rank : 47)
Query Neighborhood Hits	105	Target Neighborhood Hits	137	Shared Neighborhood Hits	28
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPV5_MOUSE
θ value	0.00175202 (rank : 35)	NC score	0.155687 (rank : 57)
Query Neighborhood Hits	105	Target Neighborhood Hits	278	Shared Neighborhood Hits	31
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

CAC1A_HUMAN
θ value	0.00665767 (rank : 36)	NC score	0.301662 (rank : 28)
Query Neighborhood Hits	105	Target Neighborhood Hits	387	Shared Neighborhood Hits	42
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

SCN1A_HUMAN
θ value	0.00665767 (rank : 37)	NC score	0.262004 (rank : 36)
Query Neighborhood Hits	105	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0.00665767 (rank : 38)	NC score	0.261554 (rank : 37)
Query Neighborhood Hits	105	Target Neighborhood Hits	157	Shared Neighborhood Hits	42
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

TRPC6_HUMAN
θ value	0.00665767 (rank : 39)	NC score	0.183005 (rank : 51)
Query Neighborhood Hits	105	Target Neighborhood Hits	171	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC6_MOUSE
θ value	0.00665767 (rank : 40)	NC score	0.183771 (rank : 50)
Query Neighborhood Hits	105	Target Neighborhood Hits	171	Shared Neighborhood Hits	28
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

CAC1A_MOUSE
θ value	0.00869519 (rank : 41)	NC score	0.304126 (rank : 27)
Query Neighborhood Hits	105	Target Neighborhood Hits	267	Shared Neighborhood Hits	42
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

SCN9A_HUMAN
θ value	0.00869519 (rank : 42)	NC score	0.264411 (rank : 35)
Query Neighborhood Hits	105	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SC10A_HUMAN
θ value	0.0113563 (rank : 43)	NC score	0.268482 (rank : 33)
Query Neighborhood Hits	105	Target Neighborhood Hits	116	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

CALB2_MOUSE
θ value	0.0148317 (rank : 44)	NC score	0.094606 (rank : 69)
Query Neighborhood Hits	105	Target Neighborhood Hits	141	Shared Neighborhood Hits	17
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

SC10A_MOUSE
θ value	0.0148317 (rank : 45)	NC score	0.267212 (rank : 34)
Query Neighborhood Hits	105	Target Neighborhood Hits	107	Shared Neighborhood Hits	47
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

CALB2_HUMAN
θ value	0.0193708 (rank : 46)	NC score	0.082806 (rank : 71)
Query Neighborhood Hits	105	Target Neighborhood Hits	149	Shared Neighborhood Hits	16
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

SCN3A_HUMAN
θ value	0.0193708 (rank : 47)	NC score	0.260187 (rank : 38)
Query Neighborhood Hits	105	Target Neighborhood Hits	115	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

TRPV5_HUMAN
θ value	0.0252991 (rank : 48)	NC score	0.126972 (rank : 63)
Query Neighborhood Hits	105	Target Neighborhood Hits	261	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

SC11A_MOUSE
θ value	0.0330416 (rank : 49)	NC score	0.270145 (rank : 32)
Query Neighborhood Hits	105	Target Neighborhood Hits	116	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

TRPC5_HUMAN
θ value	0.0330416 (rank : 50)	NC score	0.162770 (rank : 54)
Query Neighborhood Hits	105	Target Neighborhood Hits	122	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
θ value	0.0330416 (rank : 51)	NC score	0.162651 (rank : 56)
Query Neighborhood Hits	105	Target Neighborhood Hits	124	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

CAC1I_HUMAN
θ value	0.0563607 (rank : 52)	NC score	0.275273 (rank : 31)
Query Neighborhood Hits	105	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

SCN4A_HUMAN
θ value	0.0563607 (rank : 53)	NC score	0.260050 (rank : 39)
Query Neighborhood Hits	105	Target Neighborhood Hits	133	Shared Neighborhood Hits	45
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

BPAEA_MOUSE
θ value	0.0736092 (rank : 54)	NC score	0.016422 (rank : 92)
Query Neighborhood Hits	105	Target Neighborhood Hits	1480	Shared Neighborhood Hits	15
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

TRPV3_HUMAN
θ value	0.0961366 (rank : 55)	NC score	0.162674 (rank : 55)
Query Neighborhood Hits	105	Target Neighborhood Hits	198	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV4_MOUSE
θ value	0.0961366 (rank : 56)	NC score	0.139392 (rank : 59)
Query Neighborhood Hits	105	Target Neighborhood Hits	117	Shared Neighborhood Hits	40
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_HUMAN
θ value	0.125558 (rank : 57)	NC score	0.139059 (rank : 60)
Query Neighborhood Hits	105	Target Neighborhood Hits	150	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV6_MOUSE
θ value	0.125558 (rank : 58)	NC score	0.108748 (rank : 68)
Query Neighborhood Hits	105	Target Neighborhood Hits	284	Shared Neighborhood Hits	30
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

CALM4_MOUSE
θ value	0.163984 (rank : 59)	NC score	0.033295 (rank : 84)
Query Neighborhood Hits	105	Target Neighborhood Hits	229	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JM83, Q9CR31, Q9D1E9	Gene names	Calm4, Dd112
Domain Architecture
Description	Calmodulin-4 (Calcium-binding protein Dd112).

CO4A2_MOUSE
θ value	0.21417 (rank : 60)	NC score	0.009999 (rank : 99)
Query Neighborhood Hits	105	Target Neighborhood Hits	492	Shared Neighborhood Hits	4
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

TRPC7_HUMAN
θ value	0.365318 (rank : 61)	NC score	0.167360 (rank : 53)
Query Neighborhood Hits	105	Target Neighborhood Hits	123	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC7_MOUSE
θ value	0.365318 (rank : 62)	NC score	0.167486 (rank : 52)
Query Neighborhood Hits	105	Target Neighborhood Hits	114	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPV3_MOUSE
θ value	0.365318 (rank : 63)	NC score	0.147770 (rank : 58)
Query Neighborhood Hits	105	Target Neighborhood Hits	188	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV6_HUMAN
θ value	0.365318 (rank : 64)	NC score	0.115395 (rank : 67)
Query Neighborhood Hits	105	Target Neighborhood Hits	262	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

CF152_HUMAN
θ value	0.47712 (rank : 65)	NC score	0.027875 (rank : 86)
Query Neighborhood Hits	105	Target Neighborhood Hits	704	Shared Neighborhood Hits	13
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

SCN8A_HUMAN
θ value	0.47712 (rank : 66)	NC score	0.252575 (rank : 40)
Query Neighborhood Hits	105	Target Neighborhood Hits	135	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	0.47712 (rank : 67)	NC score	0.252251 (rank : 41)
Query Neighborhood Hits	105	Target Neighborhood Hits	136	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

COG3_MOUSE
θ value	0.62314 (rank : 68)	NC score	0.040328 (rank : 82)
Query Neighborhood Hits	105	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CI04	Gene names	Cog3
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 3.

RAD50_HUMAN
θ value	0.62314 (rank : 69)	NC score	0.016905 (rank : 91)
Query Neighborhood Hits	105	Target Neighborhood Hits	1317	Shared Neighborhood Hits	16
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

CAC1G_HUMAN
θ value	0.813845 (rank : 70)	NC score	0.248595 (rank : 42)
Query Neighborhood Hits	105	Target Neighborhood Hits	587	Shared Neighborhood Hits	44
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CALL5_HUMAN
θ value	0.813845 (rank : 71)	NC score	0.028720 (rank : 85)
Query Neighborhood Hits	105	Target Neighborhood Hits	231	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZT1, Q8IXU8	Gene names	CALML5, CLSP
Domain Architecture
Description	Calmodulin-like protein 5 (Calmodulin-like skin protein).

G6PE_HUMAN
θ value	0.813845 (rank : 72)	NC score	0.022179 (rank : 87)
Query Neighborhood Hits	105	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	O95479, Q4TT33, Q66I35, Q68DT3	Gene names	H6PD, GDH
Domain Architecture
Description	GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6- phosphogluconolactonase (EC 3.1.1.31) (6PGL)].

RAD50_MOUSE
θ value	0.813845 (rank : 73)	NC score	0.017379 (rank : 90)
Query Neighborhood Hits	105	Target Neighborhood Hits	1366	Shared Neighborhood Hits	16
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

CALB1_HUMAN
θ value	1.06291 (rank : 74)	NC score	0.061129 (rank : 79)
Query Neighborhood Hits	105	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	P05937	Gene names	CALB1, CAB27
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K).

COG3_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.038415 (rank : 83)
Query Neighborhood Hits	105	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

CHD6_HUMAN
θ value	1.38821 (rank : 76)	NC score	0.008023 (rank : 103)
Query Neighborhood Hits	105	Target Neighborhood Hits	342	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

SCN7A_HUMAN
θ value	1.38821 (rank : 77)	NC score	0.245715 (rank : 43)
Query Neighborhood Hits	105	Target Neighborhood Hits	135	Shared Neighborhood Hits	43
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

MY18A_MOUSE
θ value	1.81305 (rank : 78)	NC score	0.006884 (rank : 107)
Query Neighborhood Hits	105	Target Neighborhood Hits	1989	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

STAG3_HUMAN
θ value	2.36792 (rank : 79)	NC score	0.011958 (rank : 98)
Query Neighborhood Hits	105	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJ98, Q8NDP3	Gene names	STAG3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

CALB1_MOUSE
θ value	3.0926 (rank : 80)	NC score	0.054707 (rank : 80)
Query Neighborhood Hits	105	Target Neighborhood Hits	129	Shared Neighborhood Hits	9
SwissProt Accessions	P12658, Q545N6	Gene names	Calb1
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K) (Spot 35 protein) (PCD-29).

MELPH_MOUSE
θ value	3.0926 (rank : 81)	NC score	0.015129 (rank : 94)
Query Neighborhood Hits	105	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

SPTA1_HUMAN
θ value	3.0926 (rank : 82)	NC score	0.012867 (rank : 97)
Query Neighborhood Hits	105	Target Neighborhood Hits	748	Shared Neighborhood Hits	15
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ITPR1_HUMAN
θ value	4.03905 (rank : 83)	NC score	0.018728 (rank : 88)
Query Neighborhood Hits	105	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
θ value	4.03905 (rank : 84)	NC score	0.018617 (rank : 89)
Query Neighborhood Hits	105	Target Neighborhood Hits	99	Shared Neighborhood Hits	13
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

MY18A_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.007459 (rank : 105)
Query Neighborhood Hits	105	Target Neighborhood Hits	1929	Shared Neighborhood Hits	19
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NDE1_HUMAN
θ value	4.03905 (rank : 86)	NC score	0.014315 (rank : 95)
Query Neighborhood Hits	105	Target Neighborhood Hits	823	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

FGD1_HUMAN
θ value	5.27518 (rank : 87)	NC score	0.004048 (rank : 109)
Query Neighborhood Hits	105	Target Neighborhood Hits	367	Shared Neighborhood Hits	6
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

NRBF2_HUMAN
θ value	5.27518 (rank : 88)	NC score	0.016234 (rank : 93)
Query Neighborhood Hits	105	Target Neighborhood Hits	122	Shared Neighborhood Hits	6
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

TRPM2_MOUSE
θ value	5.27518 (rank : 89)	NC score	0.049772 (rank : 81)
Query Neighborhood Hits	105	Target Neighborhood Hits	61	Shared Neighborhood Hits	27
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

CO4A2_HUMAN
θ value	6.88961 (rank : 90)	NC score	0.006534 (rank : 108)
Query Neighborhood Hits	105	Target Neighborhood Hits	454	Shared Neighborhood Hits	6
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

EFHB_MOUSE
θ value	6.88961 (rank : 91)	NC score	0.014119 (rank : 96)
Query Neighborhood Hits	105	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CDU5	Gene names	Efhb
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member B.

MRCKA_HUMAN
θ value	6.88961 (rank : 92)	NC score	-0.000852 (rank : 113)
Query Neighborhood Hits	105	Target Neighborhood Hits	1999	Shared Neighborhood Hits	14
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MYO9B_HUMAN
θ value	6.88961 (rank : 93)	NC score	0.003467 (rank : 111)
Query Neighborhood Hits	105	Target Neighborhood Hits	641	Shared Neighborhood Hits	9
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

P2Y14_HUMAN
θ value	6.88961 (rank : 94)	NC score	-0.000906 (rank : 114)
Query Neighborhood Hits	105	Target Neighborhood Hits	533	Shared Neighborhood Hits	2
SwissProt Accessions	Q15391, Q8IYT7	Gene names	P2RY14, GPR105, KIAA0001
Domain Architecture
Description	P2Y purinoceptor 14 (P2Y14) (UDP-glucose receptor) (G-protein coupled receptor 105).

PAPPA_HUMAN
θ value	6.88961 (rank : 95)	NC score	0.009669 (rank : 100)
Query Neighborhood Hits	105	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

SAFB2_HUMAN
θ value	6.88961 (rank : 96)	NC score	0.008110 (rank : 102)
Query Neighborhood Hits	105	Target Neighborhood Hits	720	Shared Neighborhood Hits	12
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

CAC1H_MOUSE
θ value	8.99809 (rank : 97)	NC score	0.232147 (rank : 45)
Query Neighborhood Hits	105	Target Neighborhood Hits	230	Shared Neighborhood Hits	36
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CNTN5_MOUSE
θ value	8.99809 (rank : 98)	NC score	0.000580 (rank : 112)
Query Neighborhood Hits	105	Target Neighborhood Hits	434	Shared Neighborhood Hits	3
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

HDAC9_HUMAN
θ value	8.99809 (rank : 99)	NC score	0.003511 (rank : 110)
Query Neighborhood Hits	105	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKV0, O94845, O95028	Gene names	HDAC9, HDAC7, HDAC7B, KIAA0744
Domain Architecture
Description	Histone deacetylase 9 (HD9) (HD7B) (HD7).

MDM2_HUMAN
θ value	8.99809 (rank : 100)	NC score	0.007534 (rank : 104)
Query Neighborhood Hits	105	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

POPD3_MOUSE
θ value	8.99809 (rank : 101)	NC score	0.007436 (rank : 106)
Query Neighborhood Hits	105	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ES81	Gene names	Popdc3, Pop3
Domain Architecture
Description	Popeye domain-containing protein 3 (Popeye protein 3).

S45A2_HUMAN
θ value	8.99809 (rank : 102)	NC score	0.008404 (rank : 101)
Query Neighborhood Hits	105	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMX9, Q9BTM3	Gene names	SLC45A2, AIM1, MATP
Domain Architecture	No domain graphic available
Description	Membrane-associated transporter protein (Solute carrier family 45 member 2) (Protein AIM-1) (Melanoma antigen AIM1).

TRPM8_HUMAN
θ value	8.99809 (rank : 103)	NC score	0.077792 (rank : 74)
Query Neighborhood Hits	105	Target Neighborhood Hits	65	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM8_MOUSE
θ value	8.99809 (rank : 104)	NC score	0.078415 (rank : 73)
Query Neighborhood Hits	105	Target Neighborhood Hits	58	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

ZN692_MOUSE
θ value	8.99809 (rank : 105)	NC score	-0.003890 (rank : 115)
Query Neighborhood Hits	105	Target Neighborhood Hits	751	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U381	Gene names	Znf692, Zfp692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

CAC1H_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.236064 (rank : 44)
Query Neighborhood Hits	105	Target Neighborhood Hits	307	Shared Neighborhood Hits	41
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

TRPC1_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.121592 (rank : 65)
Query Neighborhood Hits	105	Target Neighborhood Hits	91	Shared Neighborhood Hits	32
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	θ > 10 (rank : 108)	NC score	0.121668 (rank : 64)
Query Neighborhood Hits	105	Target Neighborhood Hits	87	Shared Neighborhood Hits	32
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC2_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.120491 (rank : 66)
Query Neighborhood Hits	105	Target Neighborhood Hits	84	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

TRPM7_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.073989 (rank : 76)
Query Neighborhood Hits	105	Target Neighborhood Hits	104	Shared Neighborhood Hits	25
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPM7_MOUSE
θ value	θ > 10 (rank : 111)	NC score	0.076658 (rank : 75)
Query Neighborhood Hits	105	Target Neighborhood Hits	113	Shared Neighborhood Hits	27
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

TRPV1_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.084465 (rank : 70)
Query Neighborhood Hits	105	Target Neighborhood Hits	184	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.081393 (rank : 72)
Query Neighborhood Hits	105	Target Neighborhood Hits	189	Shared Neighborhood Hits	30
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV2_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.070833 (rank : 77)
Query Neighborhood Hits	105	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.070268 (rank : 78)
Query Neighborhood Hits	105	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

Hits sorted by NC score

PKD2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	105	Target Neighborhood Hits	105	Shared Neighborhood Hits	105
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PKD2_MOUSE
NC score	0.993030 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	105	Target Neighborhood Hits	99	Shared Neighborhood Hits	79
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PK2L1_HUMAN
NC score	0.969112 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	105	Target Neighborhood Hits	132	Shared Neighborhood Hits	69
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_HUMAN
NC score	0.962148 (rank : 4)	θ value	5.99046e-137 (rank : 4)
Query Neighborhood Hits	105	Target Neighborhood Hits	90	Shared Neighborhood Hits	64
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
NC score	0.961251 (rank : 5)	θ value	2.78268e-134 (rank : 5)
Query Neighborhood Hits	105	Target Neighborhood Hits	84	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKDRE_HUMAN
NC score	0.600242 (rank : 6)	θ value	1.5242e-23 (rank : 6)
Query Neighborhood Hits	105	Target Neighborhood Hits	64	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
NC score	0.571020 (rank : 7)	θ value	2.97466e-19 (rank : 8)
Query Neighborhood Hits	105	Target Neighborhood Hits	76	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PK1L1_HUMAN
NC score	0.501822 (rank : 8)	θ value	1.80466e-16 (rank : 9)
Query Neighborhood Hits	105	Target Neighborhood Hits	140	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

MCLN2_MOUSE
NC score	0.379497 (rank : 9)	θ value	4.0297e-08 (rank : 13)
Query Neighborhood Hits	105	Target Neighborhood Hits	31	Shared Neighborhood Hits	24
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN2_HUMAN
NC score	0.373907 (rank : 10)	θ value	5.26297e-08 (rank : 14)
Query Neighborhood Hits	105	Target Neighborhood Hits	23	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN3_HUMAN
NC score	0.369356 (rank : 11)	θ value	5.26297e-08 (rank : 15)
Query Neighborhood Hits	105	Target Neighborhood Hits	26	Shared Neighborhood Hits	24
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN3_MOUSE
NC score	0.366455 (rank : 12)	θ value	3.41135e-07 (rank : 18)
Query Neighborhood Hits	105	Target Neighborhood Hits	29	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

CAC1F_MOUSE
NC score	0.342516 (rank : 13)	θ value	4.0297e-08 (rank : 12)
Query Neighborhood Hits	105	Target Neighborhood Hits	142	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.339065 (rank : 14)	θ value	1.17247e-07 (rank : 17)
Query Neighborhood Hits	105	Target Neighborhood Hits	141	Shared Neighborhood Hits	35
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.337490 (rank : 15)	θ value	4.45536e-07 (rank : 19)
Query Neighborhood Hits	105	Target Neighborhood Hits	130	Shared Neighborhood Hits	35
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.336289 (rank : 16)	θ value	8.97725e-08 (rank : 16)
Query Neighborhood Hits	105	Target Neighborhood Hits	158	Shared Neighborhood Hits	35
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

MCLN1_HUMAN
NC score	0.334379 (rank : 17)	θ value	4.1701e-05 (rank : 24)
Query Neighborhood Hits	105	Target Neighborhood Hits	26	Shared Neighborhood Hits	17
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

CAC1E_MOUSE
NC score	0.332170 (rank : 18)	θ value	1.87187e-05 (rank : 22)
Query Neighborhood Hits	105	Target Neighborhood Hits	167	Shared Neighborhood Hits	42
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.330846 (rank : 19)	θ value	5.44631e-05 (rank : 25)
Query Neighborhood Hits	105	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

MCLN1_MOUSE
NC score	0.329726 (rank : 20)	θ value	9.29e-05 (rank : 27)
Query Neighborhood Hits	105	Target Neighborhood Hits	24	Shared Neighborhood Hits	18
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

CAC1B_HUMAN
NC score	0.329618 (rank : 21)	θ value	2.88788e-06 (rank : 20)
Query Neighborhood Hits	105	Target Neighborhood Hits	257	Shared Neighborhood Hits	47
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1D_HUMAN
NC score	0.327781 (rank : 22)	θ value	3.19293e-05 (rank : 23)
Query Neighborhood Hits	105	Target Neighborhood Hits	118	Shared Neighborhood Hits	37
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

PKD1_HUMAN
NC score	0.325133 (rank : 23)	θ value	3.51386e-20 (rank : 7)
Query Neighborhood Hits	105	Target Neighborhood Hits	387	Shared Neighborhood Hits	10
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

CAC1S_HUMAN
NC score	0.321794 (rank : 24)	θ value	0.000158464 (rank : 29)
Query Neighborhood Hits	105	Target Neighborhood Hits	92	Shared Neighborhood Hits	35
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_MOUSE
NC score	0.319561 (rank : 25)	θ value	9.29e-05 (rank : 26)
Query Neighborhood Hits	105	Target Neighborhood Hits	351	Shared Neighborhood Hits	44
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_MOUSE
NC score	0.319275 (rank : 26)	θ value	0.000158464 (rank : 30)
Query Neighborhood Hits	105	Target Neighborhood Hits	98	Shared Neighborhood Hits	34
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1A_MOUSE
NC score	0.304126 (rank : 27)	θ value	0.00869519 (rank : 41)
Query Neighborhood Hits	105	Target Neighborhood Hits	267	Shared Neighborhood Hits	42
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_HUMAN
NC score	0.301662 (rank : 28)	θ value	0.00665767 (rank : 36)
Query Neighborhood Hits	105	Target Neighborhood Hits	387	Shared Neighborhood Hits	42
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

SC11A_HUMAN
NC score	0.296141 (rank : 29)	θ value	8.40245e-06 (rank : 21)
Query Neighborhood Hits	105	Target Neighborhood Hits	111	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN5A_HUMAN
NC score	0.290354 (rank : 30)	θ value	9.29e-05 (rank : 28)
Query Neighborhood Hits	105	Target Neighborhood Hits	145	Shared Neighborhood Hits	43
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

CAC1I_HUMAN
NC score	0.275273 (rank : 31)	θ value	0.0563607 (rank : 52)
Query Neighborhood Hits	105	Target Neighborhood Hits	138	Shared Neighborhood Hits	36
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

SC11A_MOUSE
NC score	0.270145 (rank : 32)	θ value	0.0330416 (rank : 49)
Query Neighborhood Hits	105	Target Neighborhood Hits	116	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC10A_HUMAN
NC score	0.268482 (rank : 33)	θ value	0.0113563 (rank : 43)
Query Neighborhood Hits	105	Target Neighborhood Hits	116	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
NC score	0.267212 (rank : 34)	θ value	0.0148317 (rank : 45)
Query Neighborhood Hits	105	Target Neighborhood Hits	107	Shared Neighborhood Hits	47
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN9A_HUMAN
NC score	0.264411 (rank : 35)	θ value	0.00869519 (rank : 42)
Query Neighborhood Hits	105	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN1A_HUMAN
NC score	0.262004 (rank : 36)	θ value	0.00665767 (rank : 37)
Query Neighborhood Hits	105	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
NC score	0.261554 (rank : 37)	θ value	0.00665767 (rank : 38)
Query Neighborhood Hits	105	Target Neighborhood Hits	157	Shared Neighborhood Hits	42
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN3A_HUMAN
NC score	0.260187 (rank : 38)	θ value	0.0193708 (rank : 47)
Query Neighborhood Hits	105	Target Neighborhood Hits	115	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN4A_HUMAN
NC score	0.260050 (rank : 39)	θ value	0.0563607 (rank : 53)
Query Neighborhood Hits	105	Target Neighborhood Hits	133	Shared Neighborhood Hits	45
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN8A_HUMAN
NC score	0.252575 (rank : 40)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	105	Target Neighborhood Hits	135	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
NC score	0.252251 (rank : 41)	θ value	0.47712 (rank : 67)
Query Neighborhood Hits	105	Target Neighborhood Hits	136	Shared Neighborhood Hits	45
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1G_HUMAN
NC score	0.248595 (rank : 42)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	105	Target Neighborhood Hits	587	Shared Neighborhood Hits	44
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN7A_HUMAN
NC score	0.245715 (rank : 43)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	105	Target Neighborhood Hits	135	Shared Neighborhood Hits	43
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

CAC1H_HUMAN
NC score	0.236064 (rank : 44)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	105	Target Neighborhood Hits	307	Shared Neighborhood Hits	41
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1H_MOUSE
NC score	0.232147 (rank : 45)	θ value	8.99809 (rank : 97)
Query Neighborhood Hits	105	Target Neighborhood Hits	230	Shared Neighborhood Hits	36
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

TRPC3_MOUSE
NC score	0.205095 (rank : 46)	θ value	0.000158464 (rank : 31)
Query Neighborhood Hits	105	Target Neighborhood Hits	131	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

TRPC3_HUMAN
NC score	0.203332 (rank : 47)	θ value	0.00035302 (rank : 34)
Query Neighborhood Hits	105	Target Neighborhood Hits	137	Shared Neighborhood Hits	28
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPC4_HUMAN
NC score	0.195181 (rank : 48)	θ value	0.000270298 (rank : 32)
Query Neighborhood Hits	105	Target Neighborhood Hits	140	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.194962 (rank : 49)	θ value	0.000270298 (rank : 33)
Query Neighborhood Hits	105	Target Neighborhood Hits	141	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPC6_MOUSE
NC score	0.183771 (rank : 50)	θ value	0.00665767 (rank : 40)
Query Neighborhood Hits	105	Target Neighborhood Hits	171	Shared Neighborhood Hits	28
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPC6_HUMAN
NC score	0.183005 (rank : 51)	θ value	0.00665767 (rank : 39)
Query Neighborhood Hits	105	Target Neighborhood Hits	171	Shared Neighborhood Hits	28
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC7_MOUSE
NC score	0.167486 (rank : 52)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	105	Target Neighborhood Hits	114	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPC7_HUMAN
NC score	0.167360 (rank : 53)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	105	Target Neighborhood Hits	123	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC5_HUMAN
NC score	0.162770 (rank : 54)	θ value	0.0330416 (rank : 50)
Query Neighborhood Hits	105	Target Neighborhood Hits	122	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPV3_HUMAN
NC score	0.162674 (rank : 55)	θ value	0.0961366 (rank : 55)
Query Neighborhood Hits	105	Target Neighborhood Hits	198	Shared Neighborhood Hits	45
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPC5_MOUSE
NC score	0.162651 (rank : 56)	θ value	0.0330416 (rank : 51)
Query Neighborhood Hits	105	Target Neighborhood Hits	124	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

TRPV5_MOUSE
NC score	0.155687 (rank : 57)	θ value	0.00175202 (rank : 35)
Query Neighborhood Hits	105	Target Neighborhood Hits	278	Shared Neighborhood Hits	31
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV3_MOUSE
NC score	0.147770 (rank : 58)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	105	Target Neighborhood Hits	188	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV4_MOUSE
NC score	0.139392 (rank : 59)	θ value	0.0961366 (rank : 56)
Query Neighborhood Hits	105	Target Neighborhood Hits	117	Shared Neighborhood Hits	40
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_HUMAN
NC score	0.139059 (rank : 60)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	105	Target Neighborhood Hits	150	Shared Neighborhood Hits	40
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPA1_HUMAN
NC score	0.136842 (rank : 61)	θ value	1.06045e-08 (rank : 11)
Query Neighborhood Hits	105	Target Neighborhood Hits	339	Shared Neighborhood Hits	30
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

TRPA1_MOUSE
NC score	0.130930 (rank : 62)	θ value	8.11959e-09 (rank : 10)
Query Neighborhood Hits	105	Target Neighborhood Hits	343	Shared Neighborhood Hits	23
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

TRPV5_HUMAN
NC score	0.126972 (rank : 63)	θ value	0.0252991 (rank : 48)
Query Neighborhood Hits	105	Target Neighborhood Hits	261	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPC1_MOUSE
NC score	0.121668 (rank : 64)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	105	Target Neighborhood Hits	87	Shared Neighborhood Hits	32
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.121592 (rank : 65)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	105	Target Neighborhood Hits	91	Shared Neighborhood Hits	32
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC2_MOUSE
NC score	0.120491 (rank : 66)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	105	Target Neighborhood Hits	84	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

TRPV6_HUMAN
NC score	0.115395 (rank : 67)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	105	Target Neighborhood Hits	262	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TRPV6_MOUSE
NC score	0.108748 (rank : 68)	θ value	0.125558 (rank : 58)
Query Neighborhood Hits	105	Target Neighborhood Hits	284	Shared Neighborhood Hits	30
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

CALB2_MOUSE
NC score	0.094606 (rank : 69)	θ value	0.0148317 (rank : 44)
Query Neighborhood Hits	105	Target Neighborhood Hits	141	Shared Neighborhood Hits	17
SwissProt Accessions	Q08331, Q60964, Q9JM81	Gene names	Calb2
Domain Architecture
Description	Calretinin (CR).

TRPV1_HUMAN
NC score	0.084465 (rank : 70)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	105	Target Neighborhood Hits	184	Shared Neighborhood Hits	33
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

CALB2_HUMAN
NC score	0.082806 (rank : 71)	θ value	0.0193708 (rank : 46)
Query Neighborhood Hits	105	Target Neighborhood Hits	149	Shared Neighborhood Hits	16
SwissProt Accessions	P22676, Q53HD2, Q96BK4	Gene names	CALB2, CAB29
Domain Architecture
Description	Calretinin (CR) (29 kDa calbindin).

TRPV1_MOUSE
NC score	0.081393 (rank : 72)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	105	Target Neighborhood Hits	189	Shared Neighborhood Hits	30
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPM8_MOUSE
NC score	0.078415 (rank : 73)	θ value	8.99809 (rank : 104)
Query Neighborhood Hits	105	Target Neighborhood Hits	58	Shared Neighborhood Hits	32
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

TRPM8_HUMAN
NC score	0.077792 (rank : 74)	θ value	8.99809 (rank : 103)
Query Neighborhood Hits	105	Target Neighborhood Hits	65	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM7_MOUSE
NC score	0.076658 (rank : 75)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	105	Target Neighborhood Hits	113	Shared Neighborhood Hits	27
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

TRPM7_HUMAN
NC score	0.073989 (rank : 76)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	105	Target Neighborhood Hits	104	Shared Neighborhood Hits	25
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPV2_HUMAN
NC score	0.070833 (rank : 77)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	105	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
NC score	0.070268 (rank : 78)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	105	Target Neighborhood Hits	111	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

CALB1_HUMAN
NC score	0.061129 (rank : 79)	θ value	1.06291 (rank : 74)
Query Neighborhood Hits	105	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	P05937	Gene names	CALB1, CAB27
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K).

CALB1_MOUSE
NC score	0.054707 (rank : 80)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	105	Target Neighborhood Hits	129	Shared Neighborhood Hits	9
SwissProt Accessions	P12658, Q545N6	Gene names	Calb1
Domain Architecture
Description	Calbindin (Vitamin D-dependent calcium-binding protein, avian-type) (Calbindin D28) (D-28K) (Spot 35 protein) (PCD-29).

TRPM2_MOUSE
NC score	0.049772 (rank : 81)	θ value	5.27518 (rank : 89)
Query Neighborhood Hits	105	Target Neighborhood Hits	61	Shared Neighborhood Hits	27
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

COG3_MOUSE
NC score	0.040328 (rank : 82)	θ value	0.62314 (rank : 68)
Query Neighborhood Hits	105	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CI04	Gene names	Cog3
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 3.

COG3_HUMAN
NC score	0.038415 (rank : 83)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	105	Target Neighborhood Hits	56	Shared Neighborhood Hits	3
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

CALM4_MOUSE
NC score	0.033295 (rank : 84)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	105	Target Neighborhood Hits	229	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JM83, Q9CR31, Q9D1E9	Gene names	Calm4, Dd112
Domain Architecture
Description	Calmodulin-4 (Calcium-binding protein Dd112).

CALL5_HUMAN
NC score	0.028720 (rank : 85)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	105	Target Neighborhood Hits	231	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZT1, Q8IXU8	Gene names	CALML5, CLSP
Domain Architecture
Description	Calmodulin-like protein 5 (Calmodulin-like skin protein).

CF152_HUMAN
NC score	0.027875 (rank : 86)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	105	Target Neighborhood Hits	704	Shared Neighborhood Hits	13
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

G6PE_HUMAN
NC score	0.022179 (rank : 87)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	105	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	O95479, Q4TT33, Q66I35, Q68DT3	Gene names	H6PD, GDH
Domain Architecture
Description	GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6- phosphogluconolactonase (EC 3.1.1.31) (6PGL)].

ITPR1_HUMAN
NC score	0.018728 (rank : 88)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	105	Target Neighborhood Hits	90	Shared Neighborhood Hits	13
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
NC score	0.018617 (rank : 89)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	105	Target Neighborhood Hits	99	Shared Neighborhood Hits	13
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

RAD50_MOUSE
NC score	0.017379 (rank : 90)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	105	Target Neighborhood Hits	1366	Shared Neighborhood Hits	16
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

RAD50_HUMAN
NC score	0.016905 (rank : 91)	θ value	0.62314 (rank : 69)
Query Neighborhood Hits	105	Target Neighborhood Hits	1317	Shared Neighborhood Hits	16
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

BPAEA_MOUSE
NC score	0.016422 (rank : 92)	θ value	0.0736092 (rank : 54)
Query Neighborhood Hits	105	Target Neighborhood Hits	1480	Shared Neighborhood Hits	15
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

NRBF2_HUMAN
NC score	0.016234 (rank : 93)	θ value	5.27518 (rank : 88)
Query Neighborhood Hits	105	Target Neighborhood Hits	122	Shared Neighborhood Hits	6
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

MELPH_MOUSE
NC score	0.015129 (rank : 94)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	105	Target Neighborhood Hits	112	Shared Neighborhood Hits	3
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

NDE1_HUMAN
NC score	0.014315 (rank : 95)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	105	Target Neighborhood Hits	823	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

EFHB_MOUSE
NC score	0.014119 (rank : 96)	θ value	6.88961 (rank : 91)
Query Neighborhood Hits	105	Target Neighborhood Hits	120	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CDU5	Gene names	Efhb
Domain Architecture	No domain graphic available
Description	EF-hand domain-containing family member B.

SPTA1_HUMAN
NC score	0.012867 (rank : 97)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	105	Target Neighborhood Hits	748	Shared Neighborhood Hits	15
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

STAG3_HUMAN
NC score	0.011958 (rank : 98)	θ value	2.36792 (rank : 79)
Query Neighborhood Hits	105	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJ98, Q8NDP3	Gene names	STAG3
Domain Architecture
Description	Cohesin subunit SA-3 (Stromal antigen 3) (Stromalin 3) (SCC3 homolog 3).

CO4A2_MOUSE
NC score	0.009999 (rank : 99)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	105	Target Neighborhood Hits	492	Shared Neighborhood Hits	4
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

PAPPA_HUMAN
NC score	0.009669 (rank : 100)	θ value	6.88961 (rank : 95)
Query Neighborhood Hits	105	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q13219, Q08371, Q68G52, Q9UDK7	Gene names	PAPPA
Domain Architecture
Description	Pappalysin-1 precursor (EC 3.4.24.79) (Pregnancy-associated plasma protein-A) (PAPP-A) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase).

S45A2_HUMAN
NC score	0.008404 (rank : 101)	θ value	8.99809 (rank : 102)
Query Neighborhood Hits	105	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UMX9, Q9BTM3	Gene names	SLC45A2, AIM1, MATP
Domain Architecture	No domain graphic available
Description	Membrane-associated transporter protein (Solute carrier family 45 member 2) (Protein AIM-1) (Melanoma antigen AIM1).

SAFB2_HUMAN
NC score	0.008110 (rank : 102)	θ value	6.88961 (rank : 96)
Query Neighborhood Hits	105	Target Neighborhood Hits	720	Shared Neighborhood Hits	12
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

CHD6_HUMAN
NC score	0.008023 (rank : 103)	θ value	1.38821 (rank : 76)
Query Neighborhood Hits	105	Target Neighborhood Hits	342	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

MDM2_HUMAN
NC score	0.007534 (rank : 104)	θ value	8.99809 (rank : 100)
Query Neighborhood Hits	105	Target Neighborhood Hits	92	Shared Neighborhood Hits	2
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MY18A_HUMAN
NC score	0.007459 (rank : 105)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	105	Target Neighborhood Hits	1929	Shared Neighborhood Hits	19
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

POPD3_MOUSE
NC score	0.007436 (rank : 106)	θ value	8.99809 (rank : 101)
Query Neighborhood Hits	105	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ES81	Gene names	Popdc3, Pop3
Domain Architecture
Description	Popeye domain-containing protein 3 (Popeye protein 3).

MY18A_MOUSE
NC score	0.006884 (rank : 107)	θ value	1.81305 (rank : 78)
Query Neighborhood Hits	105	Target Neighborhood Hits	1989	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CO4A2_HUMAN
NC score	0.006534 (rank : 108)	θ value	6.88961 (rank : 90)
Query Neighborhood Hits	105	Target Neighborhood Hits	454	Shared Neighborhood Hits	6
SwissProt Accessions	P08572	Gene names	COL4A2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

FGD1_HUMAN
NC score	0.004048 (rank : 109)	θ value	5.27518 (rank : 87)
Query Neighborhood Hits	105	Target Neighborhood Hits	367	Shared Neighborhood Hits	6
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

HDAC9_HUMAN
NC score	0.003511 (rank : 110)	θ value	8.99809 (rank : 99)
Query Neighborhood Hits	105	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKV0, O94845, O95028	Gene names	HDAC9, HDAC7, HDAC7B, KIAA0744
Domain Architecture
Description	Histone deacetylase 9 (HD9) (HD7B) (HD7).

MYO9B_HUMAN
NC score	0.003467 (rank : 111)	θ value	6.88961 (rank : 93)
Query Neighborhood Hits	105	Target Neighborhood Hits	641	Shared Neighborhood Hits	9
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CNTN5_MOUSE
NC score	0.000580 (rank : 112)	θ value	8.99809 (rank : 98)
Query Neighborhood Hits	105	Target Neighborhood Hits	434	Shared Neighborhood Hits	3
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

MRCKA_HUMAN
NC score	-0.000852 (rank : 113)	θ value	6.88961 (rank : 92)
Query Neighborhood Hits	105	Target Neighborhood Hits	1999	Shared Neighborhood Hits	14
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

P2Y14_HUMAN
NC score	-0.000906 (rank : 114)	θ value	6.88961 (rank : 94)
Query Neighborhood Hits	105	Target Neighborhood Hits	533	Shared Neighborhood Hits	2
SwissProt Accessions	Q15391, Q8IYT7	Gene names	P2RY14, GPR105, KIAA0001
Domain Architecture
Description	P2Y purinoceptor 14 (P2Y14) (UDP-glucose receptor) (G-protein coupled receptor 105).

ZN692_MOUSE
NC score	-0.003890 (rank : 115)	θ value	8.99809 (rank : 105)
Query Neighborhood Hits	105	Target Neighborhood Hits	751	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U381	Gene names	Znf692, Zfp692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.