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Network neighborhood for query Sequence : ITPR1_HUMAN

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ITPR1_HUMAN
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ITPR1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
θ value	0 (rank : 2)	NC score	0.998532 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	99	Shared Neighborhood Hits	72
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

ITPR2_HUMAN
θ value	0 (rank : 3)	NC score	0.993064 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	74	Shared Neighborhood Hits	20
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

ITPR2_MOUSE
θ value	0 (rank : 4)	NC score	0.993545 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

ITPR3_HUMAN
θ value	0 (rank : 5)	NC score	0.989276 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	114	Shared Neighborhood Hits	22
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

ITPR3_MOUSE
θ value	0 (rank : 6)	NC score	0.990061 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

RYR1_HUMAN
θ value	1.01765e-35 (rank : 7)	NC score	0.555341 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	303	Shared Neighborhood Hits	14
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

RYR3_HUMAN
θ value	6.59618e-35 (rank : 8)	NC score	0.562619 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

RYR2_HUMAN
θ value	2.50655e-34 (rank : 9)	NC score	0.551793 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	12
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

BPAEA_MOUSE
θ value	0.0961366 (rank : 10)	NC score	0.026113 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	1480	Shared Neighborhood Hits	41
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

EPN4_HUMAN
θ value	0.163984 (rank : 11)	NC score	0.048904 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q14677, Q8NAF1, Q96E05	Gene names	CLINT1, ENTH, EPN4, EPNR, KIAA0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin) (Clathrin-interacting protein localized in the trans- Golgi region) (Clint).

EPN4_MOUSE
θ value	0.163984 (rank : 12)	NC score	0.048769 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q99KN9, Q8CFH4	Gene names	Clint1, Enth, Epn4, Epnr, Kiaa0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin).

OTU6A_MOUSE
θ value	0.163984 (rank : 13)	NC score	0.046463 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IE21	Gene names	Otud6a, Hin6
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 6A (Hin-6 protease).

NFH_HUMAN
θ value	0.47712 (rank : 14)	NC score	0.011211 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	1242	Shared Neighborhood Hits	35
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

GOGB1_HUMAN
θ value	0.813845 (rank : 15)	NC score	0.023473 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	2297	Shared Neighborhood Hits	49
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

SORCN_MOUSE
θ value	0.813845 (rank : 16)	NC score	0.030216 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P069, Q3UKC5, Q9CR38, Q9D7V8	Gene names	Sri
Domain Architecture	No domain graphic available
Description	Sorcin.

SORCN_HUMAN
θ value	1.06291 (rank : 17)	NC score	0.028740 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	P30626	Gene names	SRI
Domain Architecture
Description	Sorcin (22 kDa protein) (CP-22) (V19).

STRC_HUMAN
θ value	1.06291 (rank : 18)	NC score	0.027617 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q7RTU9	Gene names	STRC
Domain Architecture	No domain graphic available
Description	Stereocilin precursor.

HUWE1_HUMAN
θ value	1.38821 (rank : 19)	NC score	0.008763 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	443	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

CD2L5_HUMAN
θ value	1.81305 (rank : 20)	NC score	0.004345 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	987	Shared Neighborhood Hits	10
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	1.81305 (rank : 21)	NC score	0.004592 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	1011	Shared Neighborhood Hits	11
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CJ118_MOUSE
θ value	1.81305 (rank : 22)	NC score	0.036203 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	1132	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

DMD_HUMAN
θ value	1.81305 (rank : 23)	NC score	0.020285 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	1135	Shared Neighborhood Hits	41
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

GOGA2_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.018270 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	856	Shared Neighborhood Hits	33
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

HIP1R_MOUSE
θ value	1.81305 (rank : 25)	NC score	0.023151 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	959	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

PRKDC_MOUSE
θ value	1.81305 (rank : 26)	NC score	0.012160 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ROCK1_MOUSE
θ value	1.81305 (rank : 27)	NC score	0.011078 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	2126	Shared Neighborhood Hits	42
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

CP250_MOUSE
θ value	2.36792 (rank : 28)	NC score	0.018684 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	1583	Shared Neighborhood Hits	38
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

KIF11_HUMAN
θ value	2.36792 (rank : 29)	NC score	0.013189 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	583	Shared Neighborhood Hits	31
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

TRIO_HUMAN
θ value	2.36792 (rank : 30)	NC score	0.002920 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	1580	Shared Neighborhood Hits	32
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

CJ118_HUMAN
θ value	3.0926 (rank : 31)	NC score	0.027222 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	937	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

CLMN_MOUSE
θ value	3.0926 (rank : 32)	NC score	0.014684 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	180	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

G6PE_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.017977 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	O95479, Q4TT33, Q66I35, Q68DT3	Gene names	H6PD, GDH
Domain Architecture
Description	GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6- phosphogluconolactonase (EC 3.1.1.31) (6PGL)].

KIF11_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.013131 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	446	Shared Neighborhood Hits	30
SwissProt Accessions	Q6P9P6, Q9Z1J0	Gene names	Kif11
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5).

SC11A_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.016570 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SV2C_MOUSE
θ value	3.0926 (rank : 36)	NC score	0.007689 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q69ZS6	Gene names	Sv2c, Kiaa1054
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2C (Synaptic vesicle protein 2C).

CENPE_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.012797 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	2060	Shared Neighborhood Hits	41
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

DLG5_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.019032 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	1088	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

FBX28_HUMAN
θ value	4.03905 (rank : 39)	NC score	0.031349 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	110	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NVF7, O75070	Gene names	FBXO28, KIAA0483
Domain Architecture	No domain graphic available
Description	F-box only protein 28.

MACF1_MOUSE
θ value	4.03905 (rank : 40)	NC score	0.019512 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	1313	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

PK2L2_HUMAN
θ value	4.03905 (rank : 41)	NC score	0.019153 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
θ value	4.03905 (rank : 42)	NC score	0.019037 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.018728 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	105	Shared Neighborhood Hits	13
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

RAD50_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.016368 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	1317	Shared Neighborhood Hits	38
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAD50_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.016300 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	1366	Shared Neighborhood Hits	38
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

ROCK1_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.009306 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	2000	Shared Neighborhood Hits	41
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

TITIN_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.002551 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	2923	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TYDP1_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.018585 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NUW8, Q2HXX4, Q96BK7, Q9NZM7, Q9NZM8	Gene names	TDP1
Domain Architecture
Description	Tyrosyl-DNA phosphodiesterase 1 (EC 3.1.4.-) (Tyr-DNA phosphodiesterase 1).

CAC1G_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.008949 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	587	Shared Neighborhood Hits	10
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CLMN_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.013214 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	205	Shared Neighborhood Hits	10
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

DRAP1_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.013794 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q14919, Q13448	Gene names	DRAP1
Domain Architecture	No domain graphic available
Description	Dr1-associated corepressor (Dr1-associated protein 1) (Negative co- factor 2 alpha) (NC2 alpha).

EP15_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.030201 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	1021	Shared Neighborhood Hits	41
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

MD1L1_MOUSE
θ value	5.27518 (rank : 53)	NC score	0.015217 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	1001	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

MX2_HUMAN
θ value	5.27518 (rank : 54)	NC score	0.010506 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	P20592	Gene names	MX2
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (p78-related protein).

MYH14_MOUSE
θ value	5.27518 (rank : 55)	NC score	0.015417 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	1225	Shared Neighborhood Hits	41
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

OPTN_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.030468 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	1120	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

PHF7_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.014557 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWX1	Gene names	PHF7
Domain Architecture	No domain graphic available
Description	PHD finger protein 7 (Testis development protein NYD-SP6).

SCN7A_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.009390 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	135	Shared Neighborhood Hits	9
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

TRRAP_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.028731 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

CERU_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.008637 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q61147	Gene names	Cp
Domain Architecture
Description	Ceruloplasmin precursor (EC 1.16.3.1) (Ferroxidase).

DMP1_MOUSE
θ value	6.88961 (rank : 61)	NC score	0.014084 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	498	Shared Neighborhood Hits	11
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

GOGA6_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.013214 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	1007	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

RAI14_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.012553 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	1505	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

SELS_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.012819 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BCZ4, Q921S1, Q9DB55	Gene names	Sels, H47, Vimp
Domain Architecture
Description	Selenoprotein S (VCP-interacting membrane protein) (Minor histocompatibility antigen H47).

SMAP1_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.004700 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	120	Shared Neighborhood Hits	3
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

T22D2_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.013088 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

ADCY4_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.002410 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).

BPAEA_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.015862 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	1369	Shared Neighborhood Hits	39
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CE005_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.004198 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	238	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CRSP6_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.016649 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NVC6, Q9UNP7, Q9Y2W0, Q9Y660	Gene names	CRSP6, ARC77, DRIP77, DRIP80, TRAP80
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 6 (Cofactor required for Sp1 transcriptional activation subunit 6) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Activator-recruited cofactor 77 kDa component) (ARC77).

GOGA4_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.013191 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	1939	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

GRIPE_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.010513 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

HECD3_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.008479 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HIP1R_HUMAN
θ value	8.99809 (rank : 74)	NC score	0.015602 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	809	Shared Neighborhood Hits	33
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

INVO_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.015253 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	636	Shared Neighborhood Hits	31
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

KIME_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.008271 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q03426	Gene names	MVK
Domain Architecture
Description	Mevalonate kinase (EC 2.7.1.36) (MK).

KTN1_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.011675 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	1197	Shared Neighborhood Hits	35
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

LRC50_MOUSE
θ value	8.99809 (rank : 78)	NC score	0.005101 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D2H9, Q9CVS9	Gene names	Lrrc50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

MYH14_HUMAN
θ value	8.99809 (rank : 79)	NC score	0.008946 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	995	Shared Neighborhood Hits	37
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

NBEA_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.011591 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	186	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.011494 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

NCKX4_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.007352 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFF2, Q8N8U6, Q8NCX1, Q8NFF0, Q8NFF1	Gene names	SLC24A4, NCKX4
Domain Architecture
Description	Sodium/potassium/calcium exchanger 4 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 4) (Solute carrier family 24 member 4).

ODPA_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.007644 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P08559, Q9NP12, Q9UBJ8, Q9UBU0, Q9UNG4, Q9UNG5	Gene names	PDHA1, PHE1A
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I).

ODPA_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.007619 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P35486	Gene names	Pdha1, Pdha-1
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I).

RABE1_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.023825 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	1104	Shared Neighborhood Hits	40
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.021925 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	1105	Shared Neighborhood Hits	39
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

SCN3A_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.007541 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	115	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

TTF2_MOUSE
θ value	8.99809 (rank : 88)	NC score	0.004169 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	364	Shared Neighborhood Hits	8
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

ZCHC4_MOUSE
θ value	8.99809 (rank : 89)	NC score	0.012111 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BKW4, Q3UTX6, Q9D2I1	Gene names	Zcchc4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

ZW10_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.008976 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	O43264	Gene names	ZW10
Domain Architecture
Description	Centromere/kinetochore protein zw10 homolog.

RN123_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.054430 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

RN123_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.054309 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

Hits sorted by NC score

ITPR1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
NC score	0.998532 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	99	Shared Neighborhood Hits	72
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

ITPR2_MOUSE
NC score	0.993545 (rank : 3)	θ value	0 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	69	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Z329, P70226, Q5DWM3, Q5DWM5, Q61744, Q8R3B0	Gene names	Itpr2, Itpr5
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2) (Inositol 1,4,5-trisphosphate type V receptor).

ITPR2_HUMAN
NC score	0.993064 (rank : 4)	θ value	0 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	74	Shared Neighborhood Hits	20
SwissProt Accessions	Q14571, O94773	Gene names	ITPR2
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 2 (Type 2 inositol 1,4,5- trisphosphate receptor) (Type 2 InsP3 receptor) (IP3 receptor isoform 2) (InsP3R2).

ITPR3_MOUSE
NC score	0.990061 (rank : 5)	θ value	0 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	P70227, Q5DWM4, Q8CED5, Q91Z08	Gene names	Itpr3
Domain Architecture	No domain graphic available
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

ITPR3_HUMAN
NC score	0.989276 (rank : 6)	θ value	0 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	114	Shared Neighborhood Hits	22
SwissProt Accessions	Q14573, Q14649	Gene names	ITPR3
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 3 (Type 3 inositol 1,4,5- trisphosphate receptor) (Type 3 InsP3 receptor) (IP3 receptor isoform 3) (InsP3R3).

RYR3_HUMAN
NC score	0.562619 (rank : 7)	θ value	6.59618e-35 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	134	Shared Neighborhood Hits	11
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

RYR1_HUMAN
NC score	0.555341 (rank : 8)	θ value	1.01765e-35 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	303	Shared Neighborhood Hits	14
SwissProt Accessions	P21817, Q16314, Q16368, Q9NPK1, Q9P1U4	Gene names	RYR1, RYDR
Domain Architecture
Description	Ryanodine receptor 1 (Skeletal muscle-type ryanodine receptor) (RyR1) (RYR-1) (Skeletal muscle calcium release channel).

RYR2_HUMAN
NC score	0.551793 (rank : 9)	θ value	2.50655e-34 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	12
SwissProt Accessions	Q92736, Q15411, Q546N8	Gene names	RYR2
Domain Architecture
Description	Ryanodine receptor 2 (Cardiac muscle-type ryanodine receptor) (RyR2) (RYR-2) (Cardiac muscle ryanodine receptor-calcium release channel) (hRYR-2).

RN123_HUMAN
NC score	0.054430 (rank : 10)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	175	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

RN123_MOUSE
NC score	0.054309 (rank : 11)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	174	Shared Neighborhood Hits	3
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

EPN4_HUMAN
NC score	0.048904 (rank : 12)	θ value	0.163984 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	Q14677, Q8NAF1, Q96E05	Gene names	CLINT1, ENTH, EPN4, EPNR, KIAA0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin) (Clathrin-interacting protein localized in the trans- Golgi region) (Clint).

EPN4_MOUSE
NC score	0.048769 (rank : 13)	θ value	0.163984 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	58	Shared Neighborhood Hits	4
SwissProt Accessions	Q99KN9, Q8CFH4	Gene names	Clint1, Enth, Epn4, Epnr, Kiaa0171
Domain Architecture
Description	Clathrin interactor 1 (Epsin-4) (Epsin-related protein) (EpsinR) (Enthoprotin).

OTU6A_MOUSE
NC score	0.046463 (rank : 14)	θ value	0.163984 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	6
SwissProt Accessions	Q6IE21	Gene names	Otud6a, Hin6
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 6A (Hin-6 protease).

CJ118_MOUSE
NC score	0.036203 (rank : 15)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	1132	Shared Neighborhood Hits	42
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

FBX28_HUMAN
NC score	0.031349 (rank : 16)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	110	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NVF7, O75070	Gene names	FBXO28, KIAA0483
Domain Architecture	No domain graphic available
Description	F-box only protein 28.

OPTN_MOUSE
NC score	0.030468 (rank : 17)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	1120	Shared Neighborhood Hits	41
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

SORCN_MOUSE
NC score	0.030216 (rank : 18)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	72	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P069, Q3UKC5, Q9CR38, Q9D7V8	Gene names	Sri
Domain Architecture	No domain graphic available
Description	Sorcin.

EP15_HUMAN
NC score	0.030201 (rank : 19)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	1021	Shared Neighborhood Hits	41
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

SORCN_HUMAN
NC score	0.028740 (rank : 20)	θ value	1.06291 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	P30626	Gene names	SRI
Domain Architecture
Description	Sorcin (22 kDa protein) (CP-22) (V19).

TRRAP_HUMAN
NC score	0.028731 (rank : 21)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4A5, O75218, Q9Y631, Q9Y6H4	Gene names	TRRAP, PAF400
Domain Architecture
Description	Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog).

STRC_HUMAN
NC score	0.027617 (rank : 22)	θ value	1.06291 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q7RTU9	Gene names	STRC
Domain Architecture	No domain graphic available
Description	Stereocilin precursor.

CJ118_HUMAN
NC score	0.027222 (rank : 23)	θ value	3.0926 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	937	Shared Neighborhood Hits	39
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

BPAEA_MOUSE
NC score	0.026113 (rank : 24)	θ value	0.0961366 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	1480	Shared Neighborhood Hits	41
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

RABE1_HUMAN
NC score	0.023825 (rank : 25)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	1104	Shared Neighborhood Hits	40
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

GOGB1_HUMAN
NC score	0.023473 (rank : 26)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	2297	Shared Neighborhood Hits	49
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

HIP1R_MOUSE
NC score	0.023151 (rank : 27)	θ value	1.81305 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	959	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

RABE1_MOUSE
NC score	0.021925 (rank : 28)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	1105	Shared Neighborhood Hits	39
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

DMD_HUMAN
NC score	0.020285 (rank : 29)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	1135	Shared Neighborhood Hits	41
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

MACF1_MOUSE
NC score	0.019512 (rank : 30)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	1313	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

PK2L2_HUMAN
NC score	0.019153 (rank : 31)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
NC score	0.019037 (rank : 32)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	84	Shared Neighborhood Hits	8
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

DLG5_HUMAN
NC score	0.019032 (rank : 33)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	1088	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

PKD2_HUMAN
NC score	0.018728 (rank : 34)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	105	Shared Neighborhood Hits	13
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

CP250_MOUSE
NC score	0.018684 (rank : 35)	θ value	2.36792 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	1583	Shared Neighborhood Hits	38
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

TYDP1_HUMAN
NC score	0.018585 (rank : 36)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NUW8, Q2HXX4, Q96BK7, Q9NZM7, Q9NZM8	Gene names	TDP1
Domain Architecture
Description	Tyrosyl-DNA phosphodiesterase 1 (EC 3.1.4.-) (Tyr-DNA phosphodiesterase 1).

GOGA2_HUMAN
NC score	0.018270 (rank : 37)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	856	Shared Neighborhood Hits	33
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

G6PE_HUMAN
NC score	0.017977 (rank : 38)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	O95479, Q4TT33, Q66I35, Q68DT3	Gene names	H6PD, GDH
Domain Architecture
Description	GDH/6PGL endoplasmic bifunctional protein precursor [Includes: Glucose 1-dehydrogenase (EC 1.1.1.47) (Hexose-6-phosphate dehydrogenase); 6- phosphogluconolactonase (EC 3.1.1.31) (6PGL)].

CRSP6_HUMAN
NC score	0.016649 (rank : 39)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NVC6, Q9UNP7, Q9Y2W0, Q9Y660	Gene names	CRSP6, ARC77, DRIP77, DRIP80, TRAP80
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 6 (Cofactor required for Sp1 transcriptional activation subunit 6) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Activator-recruited cofactor 77 kDa component) (ARC77).

SC11A_MOUSE
NC score	0.016570 (rank : 40)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	116	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

RAD50_HUMAN
NC score	0.016368 (rank : 41)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	1317	Shared Neighborhood Hits	38
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

RAD50_MOUSE
NC score	0.016300 (rank : 42)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	1366	Shared Neighborhood Hits	38
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

BPAEA_HUMAN
NC score	0.015862 (rank : 43)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	1369	Shared Neighborhood Hits	39
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

HIP1R_HUMAN
NC score	0.015602 (rank : 44)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	809	Shared Neighborhood Hits	33
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

MYH14_MOUSE
NC score	0.015417 (rank : 45)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	1225	Shared Neighborhood Hits	41
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

INVO_HUMAN
NC score	0.015253 (rank : 46)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	636	Shared Neighborhood Hits	31
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

MD1L1_MOUSE
NC score	0.015217 (rank : 47)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	1001	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

CLMN_MOUSE
NC score	0.014684 (rank : 48)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	180	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

PHF7_HUMAN
NC score	0.014557 (rank : 49)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	71	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BWX1	Gene names	PHF7
Domain Architecture	No domain graphic available
Description	PHD finger protein 7 (Testis development protein NYD-SP6).

DMP1_MOUSE
NC score	0.014084 (rank : 50)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	498	Shared Neighborhood Hits	11
SwissProt Accessions	O55188	Gene names	Dmp1, Dmp
Domain Architecture
Description	Dentin matrix acidic phosphoprotein 1 precursor (Dentin matrix protein 1) (DMP-1) (AG1).

DRAP1_HUMAN
NC score	0.013794 (rank : 51)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q14919, Q13448	Gene names	DRAP1
Domain Architecture	No domain graphic available
Description	Dr1-associated corepressor (Dr1-associated protein 1) (Negative co- factor 2 alpha) (NC2 alpha).

CLMN_HUMAN
NC score	0.013214 (rank : 52)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	205	Shared Neighborhood Hits	10
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

GOGA6_HUMAN
NC score	0.013214 (rank : 53)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	1007	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

GOGA4_MOUSE
NC score	0.013191 (rank : 54)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	1939	Shared Neighborhood Hits	41
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

KIF11_HUMAN
NC score	0.013189 (rank : 55)	θ value	2.36792 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	583	Shared Neighborhood Hits	31
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

KIF11_MOUSE
NC score	0.013131 (rank : 56)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	446	Shared Neighborhood Hits	30
SwissProt Accessions	Q6P9P6, Q9Z1J0	Gene names	Kif11
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5).

T22D2_HUMAN
NC score	0.013088 (rank : 57)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	250	Shared Neighborhood Hits	3
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

SELS_MOUSE
NC score	0.012819 (rank : 58)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BCZ4, Q921S1, Q9DB55	Gene names	Sels, H47, Vimp
Domain Architecture
Description	Selenoprotein S (VCP-interacting membrane protein) (Minor histocompatibility antigen H47).

CENPE_HUMAN
NC score	0.012797 (rank : 59)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	2060	Shared Neighborhood Hits	41
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

RAI14_MOUSE
NC score	0.012553 (rank : 60)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	1505	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

PRKDC_MOUSE
NC score	0.012160 (rank : 61)	θ value	1.81305 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	92	Shared Neighborhood Hits	4
SwissProt Accessions	P97313, O88187, P97928, Q307W9, Q3V2W8, Q8C2A7, Q9Z341	Gene names	Prkdc, Xrcc7
Domain Architecture
Description	DNA-dependent protein kinase catalytic subunit (EC 2.7.11.1) (DNA-PK catalytic subunit) (DNA-PKcs) (P460).

ZCHC4_MOUSE
NC score	0.012111 (rank : 62)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BKW4, Q3UTX6, Q9D2I1	Gene names	Zcchc4
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 4.

KTN1_HUMAN
NC score	0.011675 (rank : 63)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	1197	Shared Neighborhood Hits	35
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

NBEA_HUMAN
NC score	0.011591 (rank : 64)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	186	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
NC score	0.011494 (rank : 65)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	225	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

NFH_HUMAN
NC score	0.011211 (rank : 66)	θ value	0.47712 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	1242	Shared Neighborhood Hits	35
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ROCK1_MOUSE
NC score	0.011078 (rank : 67)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	2126	Shared Neighborhood Hits	42
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

GRIPE_MOUSE
NC score	0.010513 (rank : 68)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	70	Shared Neighborhood Hits	6
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

MX2_HUMAN
NC score	0.010506 (rank : 69)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	71	Shared Neighborhood Hits	7
SwissProt Accessions	P20592	Gene names	MX2
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (p78-related protein).

SCN7A_HUMAN
NC score	0.009390 (rank : 70)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	135	Shared Neighborhood Hits	9
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

ROCK1_HUMAN
NC score	0.009306 (rank : 71)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	2000	Shared Neighborhood Hits	41
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ZW10_HUMAN
NC score	0.008976 (rank : 72)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	O43264	Gene names	ZW10
Domain Architecture
Description	Centromere/kinetochore protein zw10 homolog.

CAC1G_HUMAN
NC score	0.008949 (rank : 73)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	587	Shared Neighborhood Hits	10
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

MYH14_HUMAN
NC score	0.008946 (rank : 74)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	995	Shared Neighborhood Hits	37
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

HUWE1_HUMAN
NC score	0.008763 (rank : 75)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	443	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

CERU_MOUSE
NC score	0.008637 (rank : 76)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q61147	Gene names	Cp
Domain Architecture
Description	Ceruloplasmin precursor (EC 1.16.3.1) (Ferroxidase).

HECD3_HUMAN
NC score	0.008479 (rank : 77)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	49	Shared Neighborhood Hits	4
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

KIME_HUMAN
NC score	0.008271 (rank : 78)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q03426	Gene names	MVK
Domain Architecture
Description	Mevalonate kinase (EC 2.7.1.36) (MK).

SV2C_MOUSE
NC score	0.007689 (rank : 79)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	Q69ZS6	Gene names	Sv2c, Kiaa1054
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2C (Synaptic vesicle protein 2C).

ODPA_HUMAN
NC score	0.007644 (rank : 80)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P08559, Q9NP12, Q9UBJ8, Q9UBU0, Q9UNG4, Q9UNG5	Gene names	PDHA1, PHE1A
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I).

ODPA_MOUSE
NC score	0.007619 (rank : 81)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P35486	Gene names	Pdha1, Pdha-1
Domain Architecture
Description	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor (EC 1.2.4.1) (PDHE1-A type I).

SCN3A_HUMAN
NC score	0.007541 (rank : 82)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	115	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

NCKX4_HUMAN
NC score	0.007352 (rank : 83)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q8NFF2, Q8N8U6, Q8NCX1, Q8NFF0, Q8NFF1	Gene names	SLC24A4, NCKX4
Domain Architecture
Description	Sodium/potassium/calcium exchanger 4 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 4) (Solute carrier family 24 member 4).

LRC50_MOUSE
NC score	0.005101 (rank : 84)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D2H9, Q9CVS9	Gene names	Lrrc50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

SMAP1_MOUSE
NC score	0.004700 (rank : 85)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	120	Shared Neighborhood Hits	3
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

CD2L5_MOUSE
NC score	0.004592 (rank : 86)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	1011	Shared Neighborhood Hits	11
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CD2L5_HUMAN
NC score	0.004345 (rank : 87)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	987	Shared Neighborhood Hits	10
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CE005_MOUSE
NC score	0.004198 (rank : 88)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	238	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

TTF2_MOUSE
NC score	0.004169 (rank : 89)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	364	Shared Neighborhood Hits	8
SwissProt Accessions	Q5NC05, Q5M924	Gene names	Ttf2
Domain Architecture	No domain graphic available
Description	Transcription termination factor 2 (EC 3.6.1.-) (RNA polymerase II termination factor) (Transcription release factor 2).

TRIO_HUMAN
NC score	0.002920 (rank : 90)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	1580	Shared Neighborhood Hits	32
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

TITIN_HUMAN
NC score	0.002551 (rank : 91)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	2923	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

ADCY4_MOUSE
NC score	0.002410 (rank : 92)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q91WF3	Gene names	Adcy4
Domain Architecture
Description	Adenylate cyclase type 4 (EC 4.6.1.1) (Adenylate cyclase type IV) (ATP pyrophosphate-lyase 4) (Adenylyl cyclase 4).