Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : TRIO_HUMAN

For an explanation of this page, click here

TRIO_HUMAN
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HAPIP_HUMAN
θ value	0 (rank : 1)	NC score	0.385302 (rank : 838)
Query Neighborhood Hits	1580	Target Neighborhood Hits	350	Shared Neighborhood Hits	250
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

TRIO_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1580	Shared Neighborhood Hits	1580
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DUET_HUMAN
θ value	2.95243e-160 (rank : 3)	NC score	0.944935 (rank : 2)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1220	Shared Neighborhood Hits	1032
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DAPK3_MOUSE
θ value	9.45883e-58 (rank : 4)	NC score	0.889559 (rank : 5)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	809
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK1_HUMAN
θ value	1.15626e-55 (rank : 5)	NC score	0.801465 (rank : 424)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1130	Shared Neighborhood Hits	816
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

OBSCN_HUMAN
θ value	1.15626e-55 (rank : 6)	NC score	0.883924 (rank : 13)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1931	Shared Neighborhood Hits	1117
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

DAPK3_HUMAN
θ value	3.36421e-55 (rank : 7)	NC score	0.890046 (rank : 3)
Query Neighborhood Hits	1580	Target Neighborhood Hits	945	Shared Neighborhood Hits	853
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK1_MOUSE
θ value	1.66964e-54 (rank : 8)	NC score	0.797364 (rank : 446)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1138	Shared Neighborhood Hits	817
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK2_MOUSE
θ value	1.56274e-52 (rank : 9)	NC score	0.889370 (rank : 6)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	808
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MCF2_HUMAN
θ value	1.72781e-51 (rank : 10)	NC score	0.309259 (rank : 846)
Query Neighborhood Hits	1580	Target Neighborhood Hits	166	Shared Neighborhood Hits	130
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

DAPK2_HUMAN
θ value	2.94719e-51 (rank : 11)	NC score	0.889843 (rank : 4)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	806
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

MCF2L_MOUSE
θ value	6.56568e-51 (rank : 12)	NC score	0.324815 (rank : 844)
Query Neighborhood Hits	1580	Target Neighborhood Hits	255	Shared Neighborhood Hits	173
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

PKHG4_HUMAN
θ value	2.1121e-49 (rank : 13)	NC score	0.279825 (rank : 849)
Query Neighborhood Hits	1580	Target Neighborhood Hits	200	Shared Neighborhood Hits	75
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

ST17A_HUMAN
θ value	5.7518e-47 (rank : 14)	NC score	0.885950 (rank : 9)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	806
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
θ value	1.41672e-45 (rank : 15)	NC score	0.884637 (rank : 10)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	804
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

ST17B_MOUSE
θ value	1.85029e-45 (rank : 16)	NC score	0.883671 (rank : 16)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	807
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

SPEG_HUMAN
θ value	3.15612e-45 (rank : 17)	NC score	0.863352 (rank : 125)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1762	Shared Neighborhood Hits	1060
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

MYLK_HUMAN
θ value	3.48949e-44 (rank : 18)	NC score	0.873854 (rank : 44)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1328	Shared Neighborhood Hits	1016
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MYLK_MOUSE
θ value	2.26182e-43 (rank : 19)	NC score	0.871684 (rank : 56)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1489	Shared Neighborhood Hits	1035
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

SPEG_MOUSE
θ value	3.85808e-43 (rank : 20)	NC score	0.859922 (rank : 150)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1080
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

KCC4_MOUSE
θ value	1.46607e-42 (rank : 21)	NC score	0.887331 (rank : 7)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	822
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_HUMAN
θ value	5.57106e-42 (rank : 22)	NC score	0.886743 (rank : 8)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	804
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC1B_MOUSE
θ value	3.05695e-40 (rank : 23)	NC score	0.883995 (rank : 12)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	808
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

KCC1B_HUMAN
θ value	1.16164e-39 (rank : 24)	NC score	0.884071 (rank : 11)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	808
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1A_MOUSE
θ value	4.41421e-39 (rank : 25)	NC score	0.883374 (rank : 17)
Query Neighborhood Hits	1580	Target Neighborhood Hits	845	Shared Neighborhood Hits	813
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1A_HUMAN
θ value	1.28434e-38 (rank : 26)	NC score	0.883109 (rank : 20)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	813
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KCC1D_MOUSE
θ value	1.6774e-38 (rank : 27)	NC score	0.883886 (rank : 14)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	810
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
θ value	2.86122e-38 (rank : 28)	NC score	0.883824 (rank : 15)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	809
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

MYLK2_HUMAN
θ value	1.85459e-37 (rank : 29)	NC score	0.881938 (rank : 24)
Query Neighborhood Hits	1580	Target Neighborhood Hits	920	Shared Neighborhood Hits	816
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

KPSH1_HUMAN
θ value	9.20422e-37 (rank : 30)	NC score	0.882219 (rank : 22)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	804
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

DCAK3_HUMAN
θ value	1.20211e-36 (rank : 31)	NC score	0.882906 (rank : 21)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	814
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

KPSH1_MOUSE
θ value	1.57e-36 (rank : 32)	NC score	0.882006 (rank : 23)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	804
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

DCAK1_HUMAN
θ value	3.4976e-36 (rank : 33)	NC score	0.870937 (rank : 61)
Query Neighborhood Hits	1580	Target Neighborhood Hits	877	Shared Neighborhood Hits	815
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KCC1G_MOUSE
θ value	4.568e-36 (rank : 34)	NC score	0.880935 (rank : 25)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	811
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

DCAK3_MOUSE
θ value	5.96599e-36 (rank : 35)	NC score	0.883236 (rank : 19)
Query Neighborhood Hits	1580	Target Neighborhood Hits	922	Shared Neighborhood Hits	814
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KCC1G_HUMAN
θ value	5.96599e-36 (rank : 36)	NC score	0.880863 (rank : 26)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	810
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

TITIN_HUMAN
θ value	5.96599e-36 (rank : 37)	NC score	0.776941 (rank : 514)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2923	Shared Neighborhood Hits	1212
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

DCAK1_MOUSE
θ value	2.96089e-35 (rank : 38)	NC score	0.870524 (rank : 66)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	812
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

KPSH2_HUMAN
θ value	1.12514e-34 (rank : 39)	NC score	0.883277 (rank : 18)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	796
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

KCC2G_HUMAN
θ value	8.06329e-33 (rank : 40)	NC score	0.878895 (rank : 28)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	804
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_MOUSE
θ value	8.06329e-33 (rank : 41)	NC score	0.878963 (rank : 27)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	806
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

DCAK2_HUMAN
θ value	1.79631e-32 (rank : 42)	NC score	0.871160 (rank : 60)
Query Neighborhood Hits	1580	Target Neighborhood Hits	862	Shared Neighborhood Hits	808
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KCC2A_HUMAN
θ value	1.79631e-32 (rank : 43)	NC score	0.878661 (rank : 30)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	801
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KPCD2_HUMAN
θ value	2.34606e-32 (rank : 44)	NC score	0.871731 (rank : 54)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	816
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

DCAK2_MOUSE
θ value	3.06405e-32 (rank : 45)	NC score	0.870887 (rank : 62)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	808
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

KCC2A_MOUSE
θ value	6.82597e-32 (rank : 46)	NC score	0.878732 (rank : 29)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	800
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2D_HUMAN
θ value	6.82597e-32 (rank : 47)	NC score	0.877760 (rank : 32)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	802
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

KPCD1_HUMAN
θ value	6.82597e-32 (rank : 48)	NC score	0.871769 (rank : 51)
Query Neighborhood Hits	1580	Target Neighborhood Hits	901	Shared Neighborhood Hits	814
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

STK33_HUMAN
θ value	6.82597e-32 (rank : 49)	NC score	0.874675 (rank : 42)
Query Neighborhood Hits	1580	Target Neighborhood Hits	879	Shared Neighborhood Hits	820
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

KPCD1_MOUSE
θ value	1.16434e-31 (rank : 50)	NC score	0.872073 (rank : 50)
Query Neighborhood Hits	1580	Target Neighborhood Hits	891	Shared Neighborhood Hits	816
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

PKHG1_HUMAN
θ value	2.59387e-31 (rank : 51)	NC score	0.276150 (rank : 850)
Query Neighborhood Hits	1580	Target Neighborhood Hits	174	Shared Neighborhood Hits	87
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

SN1L1_MOUSE
θ value	2.59387e-31 (rank : 52)	NC score	0.869592 (rank : 76)
Query Neighborhood Hits	1580	Target Neighborhood Hits	895	Shared Neighborhood Hits	820
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

KS6A3_HUMAN
θ value	3.3877e-31 (rank : 53)	NC score	0.859950 (rank : 149)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	819
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_MOUSE
θ value	3.3877e-31 (rank : 54)	NC score	0.859955 (rank : 148)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	819
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KPCD3_MOUSE
θ value	7.54701e-31 (rank : 55)	NC score	0.870752 (rank : 64)
Query Neighborhood Hits	1580	Target Neighborhood Hits	901	Shared Neighborhood Hits	812
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

KPCD3_HUMAN
θ value	1.6813e-30 (rank : 56)	NC score	0.870345 (rank : 69)
Query Neighborhood Hits	1580	Target Neighborhood Hits	895	Shared Neighborhood Hits	813
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

SN1L2_MOUSE
θ value	1.6813e-30 (rank : 57)	NC score	0.869019 (rank : 83)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	827
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

MARK3_MOUSE
θ value	1.08979e-29 (rank : 58)	NC score	0.865391 (rank : 108)
Query Neighborhood Hits	1580	Target Neighborhood Hits	919	Shared Neighborhood Hits	816
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

SN1L2_HUMAN
θ value	1.4233e-29 (rank : 59)	NC score	0.868507 (rank : 88)
Query Neighborhood Hits	1580	Target Neighborhood Hits	964	Shared Neighborhood Hits	837
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L1_HUMAN
θ value	1.85889e-29 (rank : 60)	NC score	0.869997 (rank : 72)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	823
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

KCC2B_HUMAN
θ value	2.42779e-29 (rank : 61)	NC score	0.877786 (rank : 31)
Query Neighborhood Hits	1580	Target Neighborhood Hits	866	Shared Neighborhood Hits	810
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2B_MOUSE
θ value	2.42779e-29 (rank : 62)	NC score	0.876371 (rank : 36)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	802
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KS6A2_MOUSE
θ value	3.17079e-29 (rank : 63)	NC score	0.861165 (rank : 137)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	821
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

KS6A5_HUMAN
θ value	3.17079e-29 (rank : 64)	NC score	0.862989 (rank : 127)
Query Neighborhood Hits	1580	Target Neighborhood Hits	855	Shared Neighborhood Hits	814
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KS6A6_HUMAN
θ value	7.06379e-29 (rank : 65)	NC score	0.860910 (rank : 140)
Query Neighborhood Hits	1580	Target Neighborhood Hits	853	Shared Neighborhood Hits	813
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

SNRK_HUMAN
θ value	7.06379e-29 (rank : 66)	NC score	0.877070 (rank : 35)
Query Neighborhood Hits	1580	Target Neighborhood Hits	855	Shared Neighborhood Hits	802
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

KS6A1_MOUSE
θ value	9.2256e-29 (rank : 67)	NC score	0.861917 (rank : 133)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	815
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MARK1_HUMAN
θ value	9.2256e-29 (rank : 68)	NC score	0.864694 (rank : 115)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	814
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

KS6A2_HUMAN
θ value	1.2049e-28 (rank : 69)	NC score	0.860295 (rank : 145)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	817
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

MARK1_MOUSE
θ value	1.2049e-28 (rank : 70)	NC score	0.865211 (rank : 111)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	815
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

MARK4_HUMAN
θ value	1.2049e-28 (rank : 71)	NC score	0.866675 (rank : 100)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	821
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

MARK4_MOUSE
θ value	1.2049e-28 (rank : 72)	NC score	0.866759 (rank : 99)
Query Neighborhood Hits	1580	Target Neighborhood Hits	898	Shared Neighborhood Hits	820
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

NUAK2_HUMAN
θ value	1.2049e-28 (rank : 73)	NC score	0.871427 (rank : 58)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	817
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

MELK_MOUSE
θ value	1.57365e-28 (rank : 74)	NC score	0.871511 (rank : 57)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	810
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

K0999_HUMAN
θ value	2.05525e-28 (rank : 75)	NC score	0.869486 (rank : 78)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	815
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

MARK2_HUMAN
θ value	2.68423e-28 (rank : 76)	NC score	0.864685 (rank : 116)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1056	Shared Neighborhood Hits	848
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

AAPK2_HUMAN
θ value	3.50572e-28 (rank : 77)	NC score	0.870234 (rank : 70)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	809
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

HUNK_MOUSE
θ value	4.57862e-28 (rank : 78)	NC score	0.871711 (rank : 55)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	817
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

ULK2_HUMAN
θ value	4.57862e-28 (rank : 79)	NC score	0.862177 (rank : 132)
Query Neighborhood Hits	1580	Target Neighborhood Hits	979	Shared Neighborhood Hits	830
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

CHK2_MOUSE
θ value	5.97985e-28 (rank : 80)	NC score	0.877215 (rank : 33)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	802
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

K0999_MOUSE
θ value	5.97985e-28 (rank : 81)	NC score	0.869231 (rank : 81)
Query Neighborhood Hits	1580	Target Neighborhood Hits	931	Shared Neighborhood Hits	819
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

CAMKV_HUMAN
θ value	7.80994e-28 (rank : 82)	NC score	0.863947 (rank : 122)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1084	Shared Neighborhood Hits	808
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

CAMKV_MOUSE
θ value	7.80994e-28 (rank : 83)	NC score	0.868481 (rank : 90)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	773
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

HUNK_HUMAN
θ value	7.80994e-28 (rank : 84)	NC score	0.871735 (rank : 53)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	821
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

STK6_HUMAN
θ value	7.80994e-28 (rank : 85)	NC score	0.869264 (rank : 80)
Query Neighborhood Hits	1580	Target Neighborhood Hits	916	Shared Neighborhood Hits	830
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

KS6A1_HUMAN
θ value	1.02001e-27 (rank : 86)	NC score	0.859764 (rank : 154)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	819
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MARK2_MOUSE
θ value	1.02001e-27 (rank : 87)	NC score	0.864535 (rank : 119)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1018	Shared Neighborhood Hits	835
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MELK_HUMAN
θ value	1.02001e-27 (rank : 88)	NC score	0.871419 (rank : 59)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	806
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

SNRK_MOUSE
θ value	1.02001e-27 (rank : 89)	NC score	0.875943 (rank : 37)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	798
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

CSKP_HUMAN
θ value	1.73987e-27 (rank : 90)	NC score	0.832432 (rank : 292)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1022	Shared Neighborhood Hits	816
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	1.73987e-27 (rank : 91)	NC score	0.834814 (rank : 280)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1027	Shared Neighborhood Hits	819
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

NUAK1_HUMAN
θ value	1.73987e-27 (rank : 92)	NC score	0.870107 (rank : 71)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	813
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

SPTA2_HUMAN
θ value	2.27234e-27 (rank : 93)	NC score	0.231322 (rank : 866)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	355
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

BRSK1_HUMAN
θ value	2.96777e-27 (rank : 94)	NC score	0.874230 (rank : 43)
Query Neighborhood Hits	1580	Target Neighborhood Hits	942	Shared Neighborhood Hits	824
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

PHKG1_HUMAN
θ value	3.87602e-27 (rank : 95)	NC score	0.875322 (rank : 40)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	806
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

NUAK1_MOUSE
θ value	5.06226e-27 (rank : 96)	NC score	0.870426 (rank : 67)
Query Neighborhood Hits	1580	Target Neighborhood Hits	881	Shared Neighborhood Hits	814
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

PHKG1_MOUSE
θ value	5.06226e-27 (rank : 97)	NC score	0.875719 (rank : 38)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	805
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

STK36_HUMAN
θ value	5.06226e-27 (rank : 98)	NC score	0.859663 (rank : 155)
Query Neighborhood Hits	1580	Target Neighborhood Hits	896	Shared Neighborhood Hits	819
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

TSSK6_MOUSE
θ value	5.06226e-27 (rank : 99)	NC score	0.865492 (rank : 106)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	799
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

ULK2_MOUSE
θ value	5.06226e-27 (rank : 100)	NC score	0.862616 (rank : 130)
Query Neighborhood Hits	1580	Target Neighborhood Hits	943	Shared Neighborhood Hits	835
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

AAPK1_HUMAN
θ value	6.61148e-27 (rank : 101)	NC score	0.868933 (rank : 85)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	811
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_MOUSE
θ value	6.61148e-27 (rank : 102)	NC score	0.868998 (rank : 84)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	811
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

NIM1_HUMAN
θ value	6.61148e-27 (rank : 103)	NC score	0.869944 (rank : 73)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	813
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

SPTA1_HUMAN
θ value	8.63488e-27 (rank : 104)	NC score	0.232970 (rank : 865)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	341
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	1.12775e-26 (rank : 105)	NC score	0.230378 (rank : 868)
Query Neighborhood Hits	1580	Target Neighborhood Hits	675	Shared Neighborhood Hits	314
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

NIM1_MOUSE
θ value	1.47289e-26 (rank : 106)	NC score	0.871742 (rank : 52)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	814
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

PLK1_MOUSE
θ value	1.47289e-26 (rank : 107)	NC score	0.864777 (rank : 114)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	806
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

STK6_MOUSE
θ value	1.47289e-26 (rank : 108)	NC score	0.869712 (rank : 75)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	819
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

BRSK2_HUMAN
θ value	1.92365e-26 (rank : 109)	NC score	0.873822 (rank : 45)
Query Neighborhood Hits	1580	Target Neighborhood Hits	897	Shared Neighborhood Hits	817
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

PLK1_HUMAN
θ value	1.92365e-26 (rank : 110)	NC score	0.863529 (rank : 124)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	807
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

PLK4_MOUSE
θ value	2.51237e-26 (rank : 111)	NC score	0.867257 (rank : 96)
Query Neighborhood Hits	1580	Target Neighborhood Hits	879	Shared Neighborhood Hits	817
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PDPK1_HUMAN
θ value	3.28125e-26 (rank : 112)	NC score	0.865300 (rank : 110)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	809
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

PDPK1_MOUSE
θ value	4.28545e-26 (rank : 113)	NC score	0.864920 (rank : 113)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	810
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PLK4_HUMAN
θ value	4.28545e-26 (rank : 114)	NC score	0.868060 (rank : 93)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	820
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

TSSK6_HUMAN
θ value	4.28545e-26 (rank : 115)	NC score	0.865033 (rank : 112)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	800
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

TSSK3_MOUSE
θ value	7.30988e-26 (rank : 116)	NC score	0.868687 (rank : 86)
Query Neighborhood Hits	1580	Target Neighborhood Hits	806	Shared Neighborhood Hits	779
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

NUAK2_MOUSE
θ value	9.54697e-26 (rank : 117)	NC score	0.870362 (rank : 68)
Query Neighborhood Hits	1580	Target Neighborhood Hits	878	Shared Neighborhood Hits	818
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

PHKG2_MOUSE
θ value	2.12685e-25 (rank : 118)	NC score	0.875329 (rank : 39)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	810
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

CHK2_HUMAN
θ value	2.77775e-25 (rank : 119)	NC score	0.877139 (rank : 34)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	803
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

MARK3_HUMAN
θ value	3.62785e-25 (rank : 120)	NC score	0.861895 (rank : 134)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	811
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

TSSK3_HUMAN
θ value	3.62785e-25 (rank : 121)	NC score	0.868491 (rank : 89)
Query Neighborhood Hits	1580	Target Neighborhood Hits	806	Shared Neighborhood Hits	777
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

STK36_MOUSE
θ value	6.18819e-25 (rank : 122)	NC score	0.857356 (rank : 160)
Query Neighborhood Hits	1580	Target Neighborhood Hits	877	Shared Neighborhood Hits	819
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

ULK3_MOUSE
θ value	6.18819e-25 (rank : 123)	NC score	0.870628 (rank : 65)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	818
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

AKT2_MOUSE
θ value	1.37858e-24 (rank : 124)	NC score	0.854452 (rank : 183)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	803
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

ULK1_MOUSE
θ value	1.37858e-24 (rank : 125)	NC score	0.856425 (rank : 167)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1214	Shared Neighborhood Hits	848
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

KS6A4_HUMAN
θ value	1.80048e-24 (rank : 126)	NC score	0.859957 (rank : 147)
Query Neighborhood Hits	1580	Target Neighborhood Hits	868	Shared Neighborhood Hits	814
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

PHKG2_HUMAN
θ value	2.35151e-24 (rank : 127)	NC score	0.874919 (rank : 41)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	810
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

AKT2_HUMAN
θ value	3.07116e-24 (rank : 128)	NC score	0.854987 (rank : 181)
Query Neighborhood Hits	1580	Target Neighborhood Hits	878	Shared Neighborhood Hits	804
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

AURKC_HUMAN
θ value	3.07116e-24 (rank : 129)	NC score	0.869777 (rank : 74)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

KS6A4_MOUSE
θ value	3.07116e-24 (rank : 130)	NC score	0.860496 (rank : 143)
Query Neighborhood Hits	1580	Target Neighborhood Hits	866	Shared Neighborhood Hits	816
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

ULK1_HUMAN
θ value	3.07116e-24 (rank : 131)	NC score	0.859791 (rank : 153)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1121	Shared Neighborhood Hits	843
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

KAPCB_MOUSE
θ value	5.23862e-24 (rank : 132)	NC score	0.862779 (rank : 129)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	807
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

AURKC_MOUSE
θ value	8.93572e-24 (rank : 133)	NC score	0.870774 (rank : 63)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

KAPCA_HUMAN
θ value	8.93572e-24 (rank : 134)	NC score	0.863197 (rank : 126)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	810
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

MKNK2_MOUSE
θ value	8.93572e-24 (rank : 135)	NC score	0.868593 (rank : 87)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	792
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

KAPCB_HUMAN
θ value	1.16704e-23 (rank : 136)	NC score	0.862852 (rank : 128)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	807
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

TSSK4_MOUSE
θ value	1.16704e-23 (rank : 137)	NC score	0.867194 (rank : 97)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	810
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

AKT3_HUMAN
θ value	1.99067e-23 (rank : 138)	NC score	0.855888 (rank : 174)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	807
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
θ value	1.99067e-23 (rank : 139)	NC score	0.855880 (rank : 175)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	807
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

KAPCG_HUMAN
θ value	1.99067e-23 (rank : 140)	NC score	0.864546 (rank : 118)
Query Neighborhood Hits	1580	Target Neighborhood Hits	845	Shared Neighborhood Hits	812
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

SGK1_HUMAN
θ value	1.99067e-23 (rank : 141)	NC score	0.856789 (rank : 163)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	809
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_HUMAN
θ value	1.99067e-23 (rank : 142)	NC score	0.856475 (rank : 166)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	803
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

AURKB_MOUSE
θ value	2.59989e-23 (rank : 143)	NC score	0.869535 (rank : 77)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	816
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

MAST1_MOUSE
θ value	2.59989e-23 (rank : 144)	NC score	0.842105 (rank : 237)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1123	Shared Neighborhood Hits	837
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

SGK3_HUMAN
θ value	2.59989e-23 (rank : 145)	NC score	0.852394 (rank : 189)
Query Neighborhood Hits	1580	Target Neighborhood Hits	877	Shared Neighborhood Hits	803
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

KAPCA_MOUSE
θ value	3.39556e-23 (rank : 146)	NC score	0.862554 (rank : 131)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	808
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

PASK_MOUSE
θ value	3.39556e-23 (rank : 147)	NC score	0.869108 (rank : 82)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	806
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

SGK1_MOUSE
θ value	4.43474e-23 (rank : 148)	NC score	0.856677 (rank : 164)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	809
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK2_MOUSE
θ value	4.43474e-23 (rank : 149)	NC score	0.857067 (rank : 161)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	804
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

MAST1_HUMAN
θ value	7.56453e-23 (rank : 150)	NC score	0.842407 (rank : 233)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1146	Shared Neighborhood Hits	841
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

NEK6_HUMAN
θ value	7.56453e-23 (rank : 151)	NC score	0.841951 (rank : 239)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	815
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

AKT1_MOUSE
θ value	9.87957e-23 (rank : 152)	NC score	0.853385 (rank : 188)
Query Neighborhood Hits	1580	Target Neighborhood Hits	878	Shared Neighborhood Hits	811
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

NEK6_MOUSE
θ value	9.87957e-23 (rank : 153)	NC score	0.841753 (rank : 240)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	815
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

SGK3_MOUSE
θ value	9.87957e-23 (rank : 154)	NC score	0.852147 (rank : 190)
Query Neighborhood Hits	1580	Target Neighborhood Hits	882	Shared Neighborhood Hits	804
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

AKT1_HUMAN
θ value	2.20094e-22 (rank : 155)	NC score	0.853673 (rank : 186)
Query Neighborhood Hits	1580	Target Neighborhood Hits	885	Shared Neighborhood Hits	813
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

MKNK1_MOUSE
θ value	2.20094e-22 (rank : 156)	NC score	0.864186 (rank : 120)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	781
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

MKNK2_HUMAN
θ value	2.20094e-22 (rank : 157)	NC score	0.868285 (rank : 92)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	792
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

SPTB2_MOUSE
θ value	2.20094e-22 (rank : 158)	NC score	0.199301 (rank : 895)
Query Neighborhood Hits	1580	Target Neighborhood Hits	770	Shared Neighborhood Hits	305
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MAST2_MOUSE
θ value	2.87452e-22 (rank : 159)	NC score	0.845309 (rank : 211)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1110	Shared Neighborhood Hits	847
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

TSSK2_HUMAN
θ value	2.87452e-22 (rank : 160)	NC score	0.867913 (rank : 95)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	797
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

ST32B_MOUSE
θ value	3.75424e-22 (rank : 161)	NC score	0.856288 (rank : 168)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	801
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

MAPK3_MOUSE
θ value	4.9032e-22 (rank : 162)	NC score	0.872310 (rank : 49)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	789
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

MAST2_HUMAN
θ value	4.9032e-22 (rank : 163)	NC score	0.843609 (rank : 225)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1189	Shared Neighborhood Hits	856
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

MAST4_HUMAN
θ value	4.9032e-22 (rank : 164)	NC score	0.831816 (rank : 294)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1804	Shared Neighborhood Hits	898
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SPTB2_HUMAN
θ value	4.9032e-22 (rank : 165)	NC score	0.200179 (rank : 892)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	302
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

ST32B_HUMAN
θ value	6.40375e-22 (rank : 166)	NC score	0.855965 (rank : 172)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	800
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

AURKB_HUMAN
θ value	8.36355e-22 (rank : 167)	NC score	0.868287 (rank : 91)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	815
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

KGP2_HUMAN
θ value	8.36355e-22 (rank : 168)	NC score	0.854028 (rank : 185)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1023	Shared Neighborhood Hits	887
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

MAPK3_HUMAN
θ value	8.36355e-22 (rank : 169)	NC score	0.872519 (rank : 46)
Query Neighborhood Hits	1580	Target Neighborhood Hits	807	Shared Neighborhood Hits	781
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

CTRO_HUMAN
θ value	1.09232e-21 (rank : 170)	NC score	0.809363 (rank : 382)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2092	Shared Neighborhood Hits	1103
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

ULK3_HUMAN
θ value	1.42661e-21 (rank : 171)	NC score	0.869330 (rank : 79)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	805
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

CTRO_MOUSE
θ value	1.86321e-21 (rank : 172)	NC score	0.794173 (rank : 466)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2344	Shared Neighborhood Hits	1128
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

KS6A5_MOUSE
θ value	2.43343e-21 (rank : 173)	NC score	0.855299 (rank : 180)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	812
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

PRKX_MOUSE
θ value	2.43343e-21 (rank : 174)	NC score	0.860368 (rank : 144)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	812
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

TSSK1_MOUSE
θ value	3.17815e-21 (rank : 175)	NC score	0.867951 (rank : 94)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	799
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

KGP2_MOUSE
θ value	4.15078e-21 (rank : 176)	NC score	0.853655 (rank : 187)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1029	Shared Neighborhood Hits	900
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

MAST3_HUMAN
θ value	4.15078e-21 (rank : 177)	NC score	0.846233 (rank : 206)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1128	Shared Neighborhood Hits	851
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

PLK3_HUMAN
θ value	4.15078e-21 (rank : 178)	NC score	0.861316 (rank : 136)
Query Neighborhood Hits	1580	Target Neighborhood Hits	865	Shared Neighborhood Hits	814
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

GRK6_HUMAN
θ value	5.42112e-21 (rank : 179)	NC score	0.845178 (rank : 212)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	798
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

KS6B1_HUMAN
θ value	5.42112e-21 (rank : 180)	NC score	0.856227 (rank : 169)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	808
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

KS6B1_MOUSE
θ value	5.42112e-21 (rank : 181)	NC score	0.856015 (rank : 171)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	807
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

PASK_HUMAN
θ value	5.42112e-21 (rank : 182)	NC score	0.866599 (rank : 101)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	796
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

PIM1_MOUSE
θ value	7.0802e-21 (rank : 183)	NC score	0.855461 (rank : 179)
Query Neighborhood Hits	1580	Target Neighborhood Hits	787	Shared Neighborhood Hits	763
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PKN3_HUMAN
θ value	7.0802e-21 (rank : 184)	NC score	0.846672 (rank : 204)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	835
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

TSSK1_HUMAN
θ value	7.0802e-21 (rank : 185)	NC score	0.867181 (rank : 98)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	792
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK4_HUMAN
θ value	7.0802e-21 (rank : 186)	NC score	0.865901 (rank : 103)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	808
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

NEK8_HUMAN
θ value	9.24701e-21 (rank : 187)	NC score	0.836755 (rank : 269)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	813
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK8_MOUSE
θ value	9.24701e-21 (rank : 188)	NC score	0.836787 (rank : 268)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	814
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

PRKX_HUMAN
θ value	9.24701e-21 (rank : 189)	NC score	0.859913 (rank : 151)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	808
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

TSSK2_MOUSE
θ value	9.24701e-21 (rank : 190)	NC score	0.866340 (rank : 102)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	788
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

RK_MOUSE
θ value	1.2077e-20 (rank : 191)	NC score	0.850401 (rank : 191)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	801
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

KPCZ_HUMAN
θ value	1.5773e-20 (rank : 192)	NC score	0.845970 (rank : 207)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	816
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

ROCK1_HUMAN
θ value	1.5773e-20 (rank : 193)	NC score	0.807248 (rank : 390)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2000	Shared Neighborhood Hits	1096
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	1.5773e-20 (rank : 194)	NC score	0.795448 (rank : 459)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2126	Shared Neighborhood Hits	1102
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

PIM3_MOUSE
θ value	2.06002e-20 (rank : 195)	NC score	0.854971 (rank : 182)
Query Neighborhood Hits	1580	Target Neighborhood Hits	783	Shared Neighborhood Hits	767
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

PLK3_MOUSE
θ value	2.06002e-20 (rank : 196)	NC score	0.861151 (rank : 138)
Query Neighborhood Hits	1580	Target Neighborhood Hits	863	Shared Neighborhood Hits	812
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

GRK6_MOUSE
θ value	2.69047e-20 (rank : 197)	NC score	0.844531 (rank : 217)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	797
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

ST32A_HUMAN
θ value	2.69047e-20 (rank : 198)	NC score	0.856516 (rank : 165)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	804
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

FGD3_MOUSE
θ value	4.58923e-20 (rank : 199)	NC score	0.230447 (rank : 867)
Query Neighborhood Hits	1580	Target Neighborhood Hits	257	Shared Neighborhood Hits	99
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

KPCZ_MOUSE
θ value	4.58923e-20 (rank : 200)	NC score	0.845935 (rank : 208)
Query Neighborhood Hits	1580	Target Neighborhood Hits	882	Shared Neighborhood Hits	817
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

MAPK2_MOUSE
θ value	4.58923e-20 (rank : 201)	NC score	0.872410 (rank : 48)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	802
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

PIM1_HUMAN
θ value	4.58923e-20 (rank : 202)	NC score	0.855684 (rank : 176)
Query Neighborhood Hits	1580	Target Neighborhood Hits	797	Shared Neighborhood Hits	775
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

PRKY_HUMAN
θ value	4.58923e-20 (rank : 203)	NC score	0.863717 (rank : 123)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	808
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

SPTN5_HUMAN
θ value	4.58923e-20 (rank : 204)	NC score	0.186058 (rank : 936)
Query Neighborhood Hits	1580	Target Neighborhood Hits	674	Shared Neighborhood Hits	273
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

KPCA_HUMAN
θ value	5.99374e-20 (rank : 205)	NC score	0.825131 (rank : 324)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1070	Shared Neighborhood Hits	821
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

MAPK2_HUMAN
θ value	5.99374e-20 (rank : 206)	NC score	0.872433 (rank : 47)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	804
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

KKCC2_HUMAN
θ value	7.82807e-20 (rank : 207)	NC score	0.865462 (rank : 107)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	810
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KKCC2_MOUSE
θ value	7.82807e-20 (rank : 208)	NC score	0.865324 (rank : 109)
Query Neighborhood Hits	1580	Target Neighborhood Hits	855	Shared Neighborhood Hits	810
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

KPCI_HUMAN
θ value	7.82807e-20 (rank : 209)	NC score	0.848568 (rank : 194)
Query Neighborhood Hits	1580	Target Neighborhood Hits	885	Shared Neighborhood Hits	817
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

KPCI_MOUSE
θ value	7.82807e-20 (rank : 210)	NC score	0.848641 (rank : 193)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	816
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCT_MOUSE
θ value	7.82807e-20 (rank : 211)	NC score	0.844244 (rank : 221)
Query Neighborhood Hits	1580	Target Neighborhood Hits	895	Shared Neighborhood Hits	818
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCT_HUMAN
θ value	1.02238e-19 (rank : 212)	NC score	0.844104 (rank : 223)
Query Neighborhood Hits	1580	Target Neighborhood Hits	897	Shared Neighborhood Hits	820
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

CDK3_HUMAN
θ value	1.33526e-19 (rank : 213)	NC score	0.816750 (rank : 356)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	807
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

KGP1A_HUMAN
θ value	1.33526e-19 (rank : 214)	NC score	0.847645 (rank : 199)
Query Neighborhood Hits	1580	Target Neighborhood Hits	901	Shared Neighborhood Hits	819
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

KGP1B_HUMAN
θ value	1.33526e-19 (rank : 215)	NC score	0.848000 (rank : 197)
Query Neighborhood Hits	1580	Target Neighborhood Hits	921	Shared Neighborhood Hits	833
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_MOUSE
θ value	1.33526e-19 (rank : 216)	NC score	0.848058 (rank : 196)
Query Neighborhood Hits	1580	Target Neighborhood Hits	922	Shared Neighborhood Hits	833
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KS6B2_HUMAN
θ value	1.74391e-19 (rank : 217)	NC score	0.856941 (rank : 162)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

PIM3_HUMAN
θ value	1.74391e-19 (rank : 218)	NC score	0.855934 (rank : 173)
Query Neighborhood Hits	1580	Target Neighborhood Hits	789	Shared Neighborhood Hits	772
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

CDC2_HUMAN
θ value	2.27762e-19 (rank : 219)	NC score	0.819562 (rank : 350)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	809
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

KPCA_MOUSE
θ value	2.97466e-19 (rank : 220)	NC score	0.825102 (rank : 325)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1067	Shared Neighborhood Hits	818
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCE_HUMAN
θ value	2.97466e-19 (rank : 221)	NC score	0.842400 (rank : 234)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	806
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

PIM2_MOUSE
θ value	2.97466e-19 (rank : 222)	NC score	0.859806 (rank : 152)
Query Neighborhood Hits	1580	Target Neighborhood Hits	809	Shared Neighborhood Hits	783
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

PKN2_HUMAN
θ value	2.97466e-19 (rank : 223)	NC score	0.845667 (rank : 210)
Query Neighborhood Hits	1580	Target Neighborhood Hits	892	Shared Neighborhood Hits	838
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

CDKL3_MOUSE
θ value	3.88503e-19 (rank : 224)	NC score	0.833977 (rank : 283)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	808
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

ROCK2_HUMAN
θ value	3.88503e-19 (rank : 225)	NC score	0.810514 (rank : 378)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2073	Shared Neighborhood Hits	1093
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

GRK4_MOUSE
θ value	5.07402e-19 (rank : 226)	NC score	0.840264 (rank : 248)
Query Neighborhood Hits	1580	Target Neighborhood Hits	808	Shared Neighborhood Hits	788
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

KPCE_MOUSE
θ value	5.07402e-19 (rank : 227)	NC score	0.842478 (rank : 232)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	806
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MAPK5_HUMAN
θ value	5.07402e-19 (rank : 228)	NC score	0.860000 (rank : 146)
Query Neighborhood Hits	1580	Target Neighborhood Hits	795	Shared Neighborhood Hits	768
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

PKN2_MOUSE
θ value	5.07402e-19 (rank : 229)	NC score	0.845896 (rank : 209)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	836
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

STK25_HUMAN
θ value	5.07402e-19 (rank : 230)	NC score	0.820414 (rank : 341)
Query Neighborhood Hits	1580	Target Neighborhood Hits	853	Shared Neighborhood Hits	812
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MRCKB_HUMAN
θ value	6.62687e-19 (rank : 231)	NC score	0.791751 (rank : 475)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2239	Shared Neighborhood Hits	1119
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PKN3_MOUSE
θ value	6.62687e-19 (rank : 232)	NC score	0.845116 (rank : 214)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	845
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

RK_HUMAN
θ value	6.62687e-19 (rank : 233)	NC score	0.847457 (rank : 200)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	800
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

ST32A_MOUSE
θ value	6.62687e-19 (rank : 234)	NC score	0.856077 (rank : 170)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	805
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

ST38L_HUMAN
θ value	6.62687e-19 (rank : 235)	NC score	0.840014 (rank : 250)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	781
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

CDC2_MOUSE
θ value	8.65492e-19 (rank : 236)	NC score	0.819036 (rank : 354)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	807
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

CDK7_MOUSE
θ value	8.65492e-19 (rank : 237)	NC score	0.815212 (rank : 359)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	798
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

NEK7_MOUSE
θ value	8.65492e-19 (rank : 238)	NC score	0.836664 (rank : 270)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	814
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

CDK7_HUMAN
θ value	1.13037e-18 (rank : 239)	NC score	0.815144 (rank : 360)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	798
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

ROCK2_MOUSE
θ value	1.13037e-18 (rank : 240)	NC score	0.806541 (rank : 398)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2072	Shared Neighborhood Hits	1095
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

ST32C_HUMAN
θ value	1.13037e-18 (rank : 241)	NC score	0.854414 (rank : 184)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	800
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

ST32C_MOUSE
θ value	1.13037e-18 (rank : 242)	NC score	0.855553 (rank : 178)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	797
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

STK25_MOUSE
θ value	1.13037e-18 (rank : 243)	NC score	0.819798 (rank : 347)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	812
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MAPK5_MOUSE
θ value	1.47631e-18 (rank : 244)	NC score	0.860872 (rank : 141)
Query Neighborhood Hits	1580	Target Neighborhood Hits	799	Shared Neighborhood Hits	772
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

SBK1_MOUSE
θ value	1.47631e-18 (rank : 245)	NC score	0.865882 (rank : 104)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	786
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SPTN4_HUMAN
θ value	1.47631e-18 (rank : 246)	NC score	0.173096 (rank : 985)
Query Neighborhood Hits	1580	Target Neighborhood Hits	570	Shared Neighborhood Hits	252
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

MRCKB_MOUSE
θ value	1.92812e-18 (rank : 247)	NC score	0.796865 (rank : 449)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2180	Shared Neighborhood Hits	1115
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

NEK7_HUMAN
θ value	1.92812e-18 (rank : 248)	NC score	0.836251 (rank : 272)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	813
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

ST38L_MOUSE
θ value	1.92812e-18 (rank : 249)	NC score	0.835645 (rank : 274)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	779
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

KPCD_MOUSE
θ value	2.5182e-18 (rank : 250)	NC score	0.840304 (rank : 246)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	811
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KS6B2_MOUSE
θ value	2.5182e-18 (rank : 251)	NC score	0.855632 (rank : 177)
Query Neighborhood Hits	1580	Target Neighborhood Hits	871	Shared Neighborhood Hits	812
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

PLK2_HUMAN
θ value	2.5182e-18 (rank : 252)	NC score	0.858698 (rank : 156)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	811
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PLK2_MOUSE
θ value	2.5182e-18 (rank : 253)	NC score	0.858326 (rank : 158)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	810
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

SBK1_HUMAN
θ value	2.5182e-18 (rank : 254)	NC score	0.865677 (rank : 105)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	789
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SPTB1_HUMAN
θ value	2.5182e-18 (rank : 255)	NC score	0.183405 (rank : 952)
Query Neighborhood Hits	1580	Target Neighborhood Hits	541	Shared Neighborhood Hits	260
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

ULK4_MOUSE
θ value	2.5182e-18 (rank : 256)	NC score	0.858484 (rank : 157)
Query Neighborhood Hits	1580	Target Neighborhood Hits	793	Shared Neighborhood Hits	766
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

KPCG_HUMAN
θ value	3.28887e-18 (rank : 257)	NC score	0.819962 (rank : 344)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1126	Shared Neighborhood Hits	823
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PAK1_HUMAN
θ value	3.28887e-18 (rank : 258)	NC score	0.839878 (rank : 252)
Query Neighborhood Hits	1580	Target Neighborhood Hits	873	Shared Neighborhood Hits	815
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

PAK1_MOUSE
θ value	3.28887e-18 (rank : 259)	NC score	0.839155 (rank : 257)
Query Neighborhood Hits	1580	Target Neighborhood Hits	878	Shared Neighborhood Hits	815
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

STK38_HUMAN
θ value	3.28887e-18 (rank : 260)	NC score	0.839453 (rank : 253)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	790
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

GRK4_HUMAN
θ value	4.29542e-18 (rank : 261)	NC score	0.841641 (rank : 241)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	793
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

KKCC1_HUMAN
θ value	4.29542e-18 (rank : 262)	NC score	0.864168 (rank : 121)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	810
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

DMPK_HUMAN
θ value	5.60996e-18 (rank : 263)	NC score	0.836422 (rank : 271)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	844
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

FGD4_HUMAN
θ value	5.60996e-18 (rank : 264)	NC score	0.218559 (rank : 878)
Query Neighborhood Hits	1580	Target Neighborhood Hits	219	Shared Neighborhood Hits	108
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

GRK5_MOUSE
θ value	5.60996e-18 (rank : 265)	NC score	0.844701 (rank : 216)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	791
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

PIM2_HUMAN
θ value	5.60996e-18 (rank : 266)	NC score	0.858239 (rank : 159)
Query Neighborhood Hits	1580	Target Neighborhood Hits	808	Shared Neighborhood Hits	787
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

GRK5_HUMAN
θ value	7.32683e-18 (rank : 267)	NC score	0.844325 (rank : 218)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	791
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

KPCG_MOUSE
θ value	7.32683e-18 (rank : 268)	NC score	0.819940 (rank : 346)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1123	Shared Neighborhood Hits	822
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

PAK2_HUMAN
θ value	7.32683e-18 (rank : 269)	NC score	0.843335 (rank : 227)
Query Neighborhood Hits	1580	Target Neighborhood Hits	862	Shared Neighborhood Hits	819
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
θ value	7.32683e-18 (rank : 270)	NC score	0.843325 (rank : 228)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	816
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

SLK_MOUSE
θ value	7.32683e-18 (rank : 271)	NC score	0.831697 (rank : 295)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1798	Shared Neighborhood Hits	1076
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

STK24_MOUSE
θ value	7.32683e-18 (rank : 272)	NC score	0.821179 (rank : 338)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	816
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK38_MOUSE
θ value	7.32683e-18 (rank : 273)	NC score	0.838965 (rank : 258)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	790
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

CDKL4_MOUSE
θ value	9.56915e-18 (rank : 274)	NC score	0.826722 (rank : 309)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	801
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

ARHG4_HUMAN
θ value	1.24977e-17 (rank : 275)	NC score	0.248918 (rank : 852)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

KPCD_HUMAN
θ value	1.24977e-17 (rank : 276)	NC score	0.840313 (rank : 245)
Query Neighborhood Hits	1580	Target Neighborhood Hits	900	Shared Neighborhood Hits	815
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KKCC1_MOUSE
θ value	1.63225e-17 (rank : 277)	NC score	0.864678 (rank : 117)
Query Neighborhood Hits	1580	Target Neighborhood Hits	866	Shared Neighborhood Hits	813
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

PAK7_MOUSE
θ value	1.63225e-17 (rank : 278)	NC score	0.844306 (rank : 219)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	813
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

PKN1_HUMAN
θ value	1.63225e-17 (rank : 279)	NC score	0.841985 (rank : 238)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	823
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

SLK_HUMAN
θ value	1.63225e-17 (rank : 280)	NC score	0.831845 (rank : 293)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1775	Shared Neighborhood Hits	1072
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

STK24_HUMAN
θ value	2.13179e-17 (rank : 281)	NC score	0.821728 (rank : 336)
Query Neighborhood Hits	1580	Target Neighborhood Hits	853	Shared Neighborhood Hits	815
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

IKKB_MOUSE
θ value	2.7842e-17 (rank : 282)	NC score	0.847763 (rank : 198)
Query Neighborhood Hits	1580	Target Neighborhood Hits	984	Shared Neighborhood Hits	896
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

LATS1_HUMAN
θ value	2.7842e-17 (rank : 283)	NC score	0.822237 (rank : 334)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1057	Shared Neighborhood Hits	845
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

PAK7_HUMAN
θ value	2.7842e-17 (rank : 284)	NC score	0.844002 (rank : 224)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	814
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

PKN1_MOUSE
θ value	2.7842e-17 (rank : 285)	NC score	0.842611 (rank : 231)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	823
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

KPCB_HUMAN
θ value	3.63628e-17 (rank : 286)	NC score	0.819715 (rank : 348)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1121	Shared Neighborhood Hits	821
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCB_MOUSE
θ value	3.63628e-17 (rank : 287)	NC score	0.819961 (rank : 345)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1117	Shared Neighborhood Hits	821
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

PREX1_HUMAN
θ value	3.63628e-17 (rank : 288)	NC score	0.239269 (rank : 860)
Query Neighborhood Hits	1580	Target Neighborhood Hits	177	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

CDKL3_HUMAN
θ value	4.74913e-17 (rank : 289)	NC score	0.832507 (rank : 291)
Query Neighborhood Hits	1580	Target Neighborhood Hits	853	Shared Neighborhood Hits	809
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

DMPK_MOUSE
θ value	4.74913e-17 (rank : 290)	NC score	0.836140 (rank : 273)
Query Neighborhood Hits	1580	Target Neighborhood Hits	908	Shared Neighborhood Hits	836
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

FGD4_MOUSE
θ value	4.74913e-17 (rank : 291)	NC score	0.218506 (rank : 879)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	105
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

STK4_MOUSE
θ value	4.74913e-17 (rank : 292)	NC score	0.824471 (rank : 328)
Query Neighborhood Hits	1580	Target Neighborhood Hits	873	Shared Neighborhood Hits	816
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

CDK2_HUMAN
θ value	6.20254e-17 (rank : 293)	NC score	0.814470 (rank : 361)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	804
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

IKKB_HUMAN
θ value	6.20254e-17 (rank : 294)	NC score	0.847176 (rank : 201)
Query Neighborhood Hits	1580	Target Neighborhood Hits	980	Shared Neighborhood Hits	898
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

MST4_MOUSE
θ value	6.20254e-17 (rank : 295)	NC score	0.820408 (rank : 342)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	814
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

STK4_HUMAN
θ value	6.20254e-17 (rank : 296)	NC score	0.824474 (rank : 327)
Query Neighborhood Hits	1580	Target Neighborhood Hits	870	Shared Neighborhood Hits	816
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

TIAM1_HUMAN
θ value	6.20254e-17 (rank : 297)	NC score	0.225975 (rank : 873)
Query Neighborhood Hits	1580	Target Neighborhood Hits	225	Shared Neighborhood Hits	96
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG4_MOUSE
θ value	8.10077e-17 (rank : 298)	NC score	0.246767 (rank : 853)
Query Neighborhood Hits	1580	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

CDKL1_MOUSE
θ value	8.10077e-17 (rank : 299)	NC score	0.829125 (rank : 302)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	799
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

KPCL_MOUSE
θ value	8.10077e-17 (rank : 300)	NC score	0.844203 (rank : 222)
Query Neighborhood Hits	1580	Target Neighborhood Hits	891	Shared Neighborhood Hits	807
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

MST4_HUMAN
θ value	8.10077e-17 (rank : 301)	NC score	0.820304 (rank : 343)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	813
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

LATS1_MOUSE
θ value	1.058e-16 (rank : 302)	NC score	0.819646 (rank : 349)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1027	Shared Neighborhood Hits	834
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

OXSR1_HUMAN
θ value	1.058e-16 (rank : 303)	NC score	0.826562 (rank : 312)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	816
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

PAK4_HUMAN
θ value	1.058e-16 (rank : 304)	NC score	0.845164 (rank : 213)
Query Neighborhood Hits	1580	Target Neighborhood Hits	924	Shared Neighborhood Hits	832
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

ARHG6_HUMAN
θ value	1.38178e-16 (rank : 305)	NC score	0.220381 (rank : 876)
Query Neighborhood Hits	1580	Target Neighborhood Hits	376	Shared Neighborhood Hits	186
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FGD1_MOUSE
θ value	1.38178e-16 (rank : 306)	NC score	0.207397 (rank : 886)
Query Neighborhood Hits	1580	Target Neighborhood Hits	387	Shared Neighborhood Hits	126
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MKNK1_HUMAN
θ value	1.38178e-16 (rank : 307)	NC score	0.833945 (rank : 284)
Query Neighborhood Hits	1580	Target Neighborhood Hits	701	Shared Neighborhood Hits	677
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

PAK3_HUMAN
θ value	1.38178e-16 (rank : 308)	NC score	0.840031 (rank : 249)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	818
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

PAK3_MOUSE
θ value	1.38178e-16 (rank : 309)	NC score	0.840293 (rank : 247)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	819
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

CDKL2_HUMAN
θ value	1.80466e-16 (rank : 310)	NC score	0.825172 (rank : 322)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	806
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

KPCL_HUMAN
θ value	1.80466e-16 (rank : 311)	NC score	0.842821 (rank : 229)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	807
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

OXSR1_MOUSE
θ value	1.80466e-16 (rank : 312)	NC score	0.826682 (rank : 310)
Query Neighborhood Hits	1580	Target Neighborhood Hits	865	Shared Neighborhood Hits	815
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

CDKL4_HUMAN
θ value	2.35696e-16 (rank : 313)	NC score	0.824461 (rank : 329)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	797
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

NEK3_MOUSE
θ value	2.35696e-16 (rank : 314)	NC score	0.849472 (rank : 192)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	815
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

PAK6_HUMAN
θ value	2.35696e-16 (rank : 315)	NC score	0.844748 (rank : 215)
Query Neighborhood Hits	1580	Target Neighborhood Hits	915	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

TIAM1_MOUSE
θ value	2.35696e-16 (rank : 316)	NC score	0.229642 (rank : 869)
Query Neighborhood Hits	1580	Target Neighborhood Hits	205	Shared Neighborhood Hits	91
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

STK10_HUMAN
θ value	3.07829e-16 (rank : 317)	NC score	0.820970 (rank : 339)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1921	Shared Neighborhood Hits	1097
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

STK3_MOUSE
θ value	3.07829e-16 (rank : 318)	NC score	0.825282 (rank : 321)
Query Neighborhood Hits	1580	Target Neighborhood Hits	869	Shared Neighborhood Hits	818
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

CDKL1_HUMAN
θ value	4.02038e-16 (rank : 319)	NC score	0.828480 (rank : 306)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	801
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

CDKL2_MOUSE
θ value	4.02038e-16 (rank : 320)	NC score	0.826030 (rank : 314)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	803
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

GRK7_HUMAN
θ value	4.02038e-16 (rank : 321)	NC score	0.843476 (rank : 226)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	794
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

PCTK2_HUMAN
θ value	4.02038e-16 (rank : 322)	NC score	0.806972 (rank : 394)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	796
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

STK10_MOUSE
θ value	4.02038e-16 (rank : 323)	NC score	0.805208 (rank : 410)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2132	Shared Neighborhood Hits	1104
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CDK2_MOUSE
θ value	5.25075e-16 (rank : 324)	NC score	0.811851 (rank : 370)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	800
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

FGD1_HUMAN
θ value	5.25075e-16 (rank : 325)	NC score	0.205796 (rank : 887)
Query Neighborhood Hits	1580	Target Neighborhood Hits	367	Shared Neighborhood Hits	124
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

NEK1_HUMAN
θ value	5.25075e-16 (rank : 326)	NC score	0.846395 (rank : 205)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1129	Shared Neighborhood Hits	901
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

FGD3_HUMAN
θ value	6.85773e-16 (rank : 327)	NC score	0.219799 (rank : 877)
Query Neighborhood Hits	1580	Target Neighborhood Hits	249	Shared Neighborhood Hits	92
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

IKKA_MOUSE
θ value	6.85773e-16 (rank : 328)	NC score	0.842377 (rank : 235)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	823
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

MRCKA_HUMAN
θ value	6.85773e-16 (rank : 329)	NC score	0.807828 (rank : 387)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1999	Shared Neighborhood Hits	1104
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

M3K15_HUMAN
θ value	8.95645e-16 (rank : 330)	NC score	0.833309 (rank : 288)
Query Neighborhood Hits	1580	Target Neighborhood Hits	914	Shared Neighborhood Hits	839
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

LATS2_HUMAN
θ value	1.16975e-15 (rank : 331)	NC score	0.819071 (rank : 353)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	800
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

LATS2_MOUSE
θ value	1.16975e-15 (rank : 332)	NC score	0.819105 (rank : 352)
Query Neighborhood Hits	1580	Target Neighborhood Hits	879	Shared Neighborhood Hits	800
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

NEK1_MOUSE
θ value	1.16975e-15 (rank : 333)	NC score	0.844250 (rank : 220)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1311	Shared Neighborhood Hits	928
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

STK3_HUMAN
θ value	1.16975e-15 (rank : 334)	NC score	0.824854 (rank : 326)
Query Neighborhood Hits	1580	Target Neighborhood Hits	861	Shared Neighborhood Hits	816
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

M3K14_MOUSE
θ value	1.52774e-15 (rank : 335)	NC score	0.834927 (rank : 279)
Query Neighborhood Hits	1580	Target Neighborhood Hits	889	Shared Neighborhood Hits	795
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

MP2K1_HUMAN
θ value	1.52774e-15 (rank : 336)	NC score	0.825354 (rank : 320)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	801
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

NEK3_HUMAN
θ value	1.52774e-15 (rank : 337)	NC score	0.848552 (rank : 195)
Query Neighborhood Hits	1580	Target Neighborhood Hits	865	Shared Neighborhood Hits	820
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

NEK9_HUMAN
θ value	1.52774e-15 (rank : 338)	NC score	0.821776 (rank : 335)
Query Neighborhood Hits	1580	Target Neighborhood Hits	900	Shared Neighborhood Hits	824
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

PCTK3_HUMAN
θ value	1.52774e-15 (rank : 339)	NC score	0.809440 (rank : 381)
Query Neighborhood Hits	1580	Target Neighborhood Hits	827	Shared Neighborhood Hits	795
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

ARHG9_HUMAN
θ value	1.99529e-15 (rank : 340)	NC score	0.246609 (rank : 854)
Query Neighborhood Hits	1580	Target Neighborhood Hits	235	Shared Neighborhood Hits	124
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

M3K3_MOUSE
θ value	1.99529e-15 (rank : 341)	NC score	0.839164 (rank : 256)
Query Neighborhood Hits	1580	Target Neighborhood Hits	876	Shared Neighborhood Hits	819
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MP2K1_MOUSE
θ value	1.99529e-15 (rank : 342)	NC score	0.825169 (rank : 323)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	801
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

YSK4_HUMAN
θ value	1.99529e-15 (rank : 343)	NC score	0.827451 (rank : 307)
Query Neighborhood Hits	1580	Target Neighborhood Hits	921	Shared Neighborhood Hits	817
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

ARHG9_MOUSE
θ value	2.60593e-15 (rank : 344)	NC score	0.246550 (rank : 855)
Query Neighborhood Hits	1580	Target Neighborhood Hits	234	Shared Neighborhood Hits	123
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

FGD2_HUMAN
θ value	2.60593e-15 (rank : 345)	NC score	0.215053 (rank : 882)
Query Neighborhood Hits	1580	Target Neighborhood Hits	151	Shared Neighborhood Hits	83
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

IKKA_HUMAN
θ value	2.60593e-15 (rank : 346)	NC score	0.840851 (rank : 243)
Query Neighborhood Hits	1580	Target Neighborhood Hits	863	Shared Neighborhood Hits	816
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

PCTK2_MOUSE
θ value	2.60593e-15 (rank : 347)	NC score	0.806555 (rank : 397)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	796
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

FGD2_MOUSE
θ value	3.40345e-15 (rank : 348)	NC score	0.213519 (rank : 884)
Query Neighborhood Hits	1580	Target Neighborhood Hits	163	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

M3K2_MOUSE
θ value	3.40345e-15 (rank : 349)	NC score	0.840724 (rank : 244)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	810
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

SPTB1_MOUSE
θ value	3.40345e-15 (rank : 350)	NC score	0.184729 (rank : 944)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	251
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

MRCKG_HUMAN
θ value	4.44505e-15 (rank : 351)	NC score	0.829996 (rank : 299)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1519	Shared Neighborhood Hits	1038
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

NEK9_MOUSE
θ value	4.44505e-15 (rank : 352)	NC score	0.821475 (rank : 337)
Query Neighborhood Hits	1580	Target Neighborhood Hits	890	Shared Neighborhood Hits	820
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

STK39_HUMAN
θ value	4.44505e-15 (rank : 353)	NC score	0.825644 (rank : 318)
Query Neighborhood Hits	1580	Target Neighborhood Hits	882	Shared Neighborhood Hits	820
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

STK39_MOUSE
θ value	4.44505e-15 (rank : 354)	NC score	0.825819 (rank : 315)
Query Neighborhood Hits	1580	Target Neighborhood Hits	915	Shared Neighborhood Hits	824
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

CDKL5_HUMAN
θ value	5.8054e-15 (rank : 355)	NC score	0.830193 (rank : 298)
Query Neighborhood Hits	1580	Target Neighborhood Hits	967	Shared Neighborhood Hits	820
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

HIPK3_HUMAN
θ value	5.8054e-15 (rank : 356)	NC score	0.784622 (rank : 497)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	782
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

HIPK3_MOUSE
θ value	5.8054e-15 (rank : 357)	NC score	0.786848 (rank : 491)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	784
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

MRCKG_MOUSE
θ value	5.8054e-15 (rank : 358)	NC score	0.829634 (rank : 300)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1466	Shared Neighborhood Hits	1050
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

PCTK1_HUMAN
θ value	5.8054e-15 (rank : 359)	NC score	0.810353 (rank : 379)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	799
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
θ value	5.8054e-15 (rank : 360)	NC score	0.810032 (rank : 380)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	798
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK3_MOUSE
θ value	5.8054e-15 (rank : 361)	NC score	0.811581 (rank : 373)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	798
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

ARBK2_HUMAN
θ value	7.58209e-15 (rank : 362)	NC score	0.835398 (rank : 277)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	799
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

BPAEA_HUMAN
θ value	7.58209e-15 (rank : 363)	NC score	0.181541 (rank : 963)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1369	Shared Neighborhood Hits	345
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

M3K1_MOUSE
θ value	7.58209e-15 (rank : 364)	NC score	0.838948 (rank : 259)
Query Neighborhood Hits	1580	Target Neighborhood Hits	952	Shared Neighborhood Hits	828
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

ARHG6_MOUSE
θ value	9.90251e-15 (rank : 365)	NC score	0.213660 (rank : 883)
Query Neighborhood Hits	1580	Target Neighborhood Hits	394	Shared Neighborhood Hits	198
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

M3K6_HUMAN
θ value	9.90251e-15 (rank : 366)	NC score	0.835467 (rank : 276)
Query Neighborhood Hits	1580	Target Neighborhood Hits	889	Shared Neighborhood Hits	822
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

M4K1_HUMAN
θ value	9.90251e-15 (rank : 367)	NC score	0.814330 (rank : 362)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	816
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

ARHG7_HUMAN
θ value	1.68911e-14 (rank : 368)	NC score	0.223269 (rank : 875)
Query Neighborhood Hits	1580	Target Neighborhood Hits	347	Shared Neighborhood Hits	159
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

M3K2_HUMAN
θ value	1.68911e-14 (rank : 369)	NC score	0.838545 (rank : 262)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	811
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
θ value	1.68911e-14 (rank : 370)	NC score	0.838387 (rank : 263)
Query Neighborhood Hits	1580	Target Neighborhood Hits	885	Shared Neighborhood Hits	819
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

MYO3B_HUMAN
θ value	1.68911e-14 (rank : 371)	NC score	0.735300 (rank : 567)
Query Neighborhood Hits	1580	Target Neighborhood Hits	923	Shared Neighborhood Hits	833
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

ARBK1_HUMAN
θ value	2.20605e-14 (rank : 372)	NC score	0.835232 (rank : 278)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	803
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
θ value	2.20605e-14 (rank : 373)	NC score	0.834141 (rank : 282)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	800
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

BPA1_MOUSE
θ value	2.20605e-14 (rank : 374)	NC score	0.181381 (rank : 965)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1477	Shared Neighborhood Hits	388
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

PAK4_MOUSE
θ value	2.20605e-14 (rank : 375)	NC score	0.841041 (rank : 242)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1098	Shared Neighborhood Hits	840
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

CDK3_MOUSE
θ value	2.88119e-14 (rank : 376)	NC score	0.820802 (rank : 340)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	799
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

M3K14_HUMAN
θ value	2.88119e-14 (rank : 377)	NC score	0.838665 (rank : 261)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	799
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

MP2K2_HUMAN
θ value	2.88119e-14 (rank : 378)	NC score	0.825746 (rank : 316)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	804
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

DNMBP_HUMAN
θ value	3.76295e-14 (rank : 379)	NC score	0.216672 (rank : 880)
Query Neighborhood Hits	1580	Target Neighborhood Hits	413	Shared Neighborhood Hits	193
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

M3K13_HUMAN
θ value	4.91457e-14 (rank : 380)	NC score	0.781665 (rank : 508)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	818
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

M3K5_HUMAN
θ value	8.38298e-14 (rank : 381)	NC score	0.833892 (rank : 285)
Query Neighborhood Hits	1580	Target Neighborhood Hits	868	Shared Neighborhood Hits	814
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K5_MOUSE
θ value	8.38298e-14 (rank : 382)	NC score	0.833831 (rank : 287)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	812
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M4K1_MOUSE
θ value	8.38298e-14 (rank : 383)	NC score	0.813330 (rank : 365)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	810
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

MP2K2_MOUSE
θ value	1.09485e-13 (rank : 384)	NC score	0.823978 (rank : 331)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	803
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

ARHG7_MOUSE
θ value	1.42992e-13 (rank : 385)	NC score	0.225422 (rank : 874)
Query Neighborhood Hits	1580	Target Neighborhood Hits	396	Shared Neighborhood Hits	202
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CDK6_MOUSE
θ value	1.42992e-13 (rank : 386)	NC score	0.805292 (rank : 409)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	804
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

HIPK2_HUMAN
θ value	1.42992e-13 (rank : 387)	NC score	0.782285 (rank : 504)
Query Neighborhood Hits	1580	Target Neighborhood Hits	845	Shared Neighborhood Hits	780
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

HIPK2_MOUSE
θ value	1.42992e-13 (rank : 388)	NC score	0.781823 (rank : 507)
Query Neighborhood Hits	1580	Target Neighborhood Hits	871	Shared Neighborhood Hits	779
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

LRRK2_HUMAN
θ value	1.42992e-13 (rank : 389)	NC score	0.700111 (rank : 590)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1382	Shared Neighborhood Hits	840
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

MAK_MOUSE
θ value	1.42992e-13 (rank : 390)	NC score	0.810574 (rank : 377)
Query Neighborhood Hits	1580	Target Neighborhood Hits	873	Shared Neighborhood Hits	806
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

STK11_HUMAN
θ value	1.42992e-13 (rank : 391)	NC score	0.861674 (rank : 135)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	803
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

MYO3A_HUMAN
θ value	1.86753e-13 (rank : 392)	NC score	0.741795 (rank : 562)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1033	Shared Neighborhood Hits	872
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

VAV_MOUSE
θ value	1.86753e-13 (rank : 393)	NC score	0.242709 (rank : 857)
Query Neighborhood Hits	1580	Target Neighborhood Hits	430	Shared Neighborhood Hits	193
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CDK6_HUMAN
θ value	2.43908e-13 (rank : 394)	NC score	0.804761 (rank : 413)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	804
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

CHK1_HUMAN
θ value	2.43908e-13 (rank : 395)	NC score	0.860718 (rank : 142)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	803
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

HIPK1_HUMAN
θ value	2.43908e-13 (rank : 396)	NC score	0.784411 (rank : 499)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	777
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
θ value	2.43908e-13 (rank : 397)	NC score	0.784239 (rank : 500)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	775
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

MK15_HUMAN
θ value	2.43908e-13 (rank : 398)	NC score	0.811634 (rank : 372)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1038	Shared Neighborhood Hits	812
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

M3K4_HUMAN
θ value	3.18553e-13 (rank : 399)	NC score	0.834212 (rank : 281)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

TAOK3_MOUSE
θ value	3.18553e-13 (rank : 400)	NC score	0.802706 (rank : 420)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1458	Shared Neighborhood Hits	1031
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

FARP2_MOUSE
θ value	4.16044e-13 (rank : 401)	NC score	0.147592 (rank : 1063)
Query Neighborhood Hits	1580	Target Neighborhood Hits	209	Shared Neighborhood Hits	96
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

CHK1_MOUSE
θ value	5.43371e-13 (rank : 402)	NC score	0.860984 (rank : 139)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	807
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

HIPK4_HUMAN
θ value	5.43371e-13 (rank : 403)	NC score	0.805671 (rank : 404)
Query Neighborhood Hits	1580	Target Neighborhood Hits	799	Shared Neighborhood Hits	766
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

ABL1_MOUSE
θ value	7.09661e-13 (rank : 404)	NC score	0.685051 (rank : 609)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1178	Shared Neighborhood Hits	873
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

FGD6_MOUSE
θ value	7.09661e-13 (rank : 405)	NC score	0.190615 (rank : 924)
Query Neighborhood Hits	1580	Target Neighborhood Hits	282	Shared Neighborhood Hits	113
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

TAOK3_HUMAN
θ value	7.09661e-13 (rank : 406)	NC score	0.802854 (rank : 418)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1494	Shared Neighborhood Hits	1032
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

TLK2_HUMAN
θ value	7.09661e-13 (rank : 407)	NC score	0.842204 (rank : 236)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1044	Shared Neighborhood Hits	886
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

TLK2_MOUSE
θ value	7.09661e-13 (rank : 408)	NC score	0.842682 (rank : 230)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1088	Shared Neighborhood Hits	907
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

ABL1_HUMAN
θ value	9.26847e-13 (rank : 409)	NC score	0.683891 (rank : 612)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1220	Shared Neighborhood Hits	873
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

M3K4_MOUSE
θ value	9.26847e-13 (rank : 410)	NC score	0.833045 (rank : 289)
Query Neighborhood Hits	1580	Target Neighborhood Hits	924	Shared Neighborhood Hits	832
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

VAV2_HUMAN
θ value	9.26847e-13 (rank : 411)	NC score	0.239041 (rank : 861)
Query Neighborhood Hits	1580	Target Neighborhood Hits	453	Shared Neighborhood Hits	200
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ABL2_HUMAN
θ value	1.2105e-12 (rank : 412)	NC score	0.681336 (rank : 619)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1045	Shared Neighborhood Hits	841
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

DYRK2_HUMAN
θ value	1.2105e-12 (rank : 413)	NC score	0.798643 (rank : 437)
Query Neighborhood Hits	1580	Target Neighborhood Hits	799	Shared Neighborhood Hits	766
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

KSYK_MOUSE
θ value	1.2105e-12 (rank : 414)	NC score	0.690626 (rank : 597)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	807
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CSK21_HUMAN
θ value	1.58096e-12 (rank : 415)	NC score	0.806556 (rank : 396)
Query Neighborhood Hits	1580	Target Neighborhood Hits	772	Shared Neighborhood Hits	747
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

CSK21_MOUSE
θ value	1.58096e-12 (rank : 416)	NC score	0.806991 (rank : 393)
Query Neighborhood Hits	1580	Target Neighborhood Hits	770	Shared Neighborhood Hits	747
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

M4K3_HUMAN
θ value	1.58096e-12 (rank : 417)	NC score	0.815787 (rank : 357)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	809
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MK12_MOUSE
θ value	1.58096e-12 (rank : 418)	NC score	0.808629 (rank : 384)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	800
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MK14_MOUSE
θ value	1.58096e-12 (rank : 419)	NC score	0.805670 (rank : 405)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	805
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

PFTK1_MOUSE
θ value	1.58096e-12 (rank : 420)	NC score	0.813096 (rank : 366)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	800
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

TLK1_HUMAN
θ value	1.58096e-12 (rank : 421)	NC score	0.839437 (rank : 254)
Query Neighborhood Hits	1580	Target Neighborhood Hits	967	Shared Neighborhood Hits	849
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

TLK1_MOUSE
θ value	1.58096e-12 (rank : 422)	NC score	0.839931 (rank : 251)
Query Neighborhood Hits	1580	Target Neighborhood Hits	947	Shared Neighborhood Hits	839
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

VAV_HUMAN
θ value	1.58096e-12 (rank : 423)	NC score	0.244705 (rank : 856)
Query Neighborhood Hits	1580	Target Neighborhood Hits	452	Shared Neighborhood Hits	198
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

LRRK2_MOUSE
θ value	2.0648e-12 (rank : 424)	NC score	0.682652 (rank : 615)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1359	Shared Neighborhood Hits	829
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

M3K12_HUMAN
θ value	2.0648e-12 (rank : 425)	NC score	0.771829 (rank : 525)
Query Neighborhood Hits	1580	Target Neighborhood Hits	940	Shared Neighborhood Hits	836
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
θ value	2.0648e-12 (rank : 426)	NC score	0.771618 (rank : 526)
Query Neighborhood Hits	1580	Target Neighborhood Hits	957	Shared Neighborhood Hits	839
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

MAK_HUMAN
θ value	2.0648e-12 (rank : 427)	NC score	0.809036 (rank : 383)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	802
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

PFTK1_HUMAN
θ value	2.0648e-12 (rank : 428)	NC score	0.812752 (rank : 367)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	796
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

KSYK_HUMAN
θ value	2.69671e-12 (rank : 429)	NC score	0.690508 (rank : 598)
Query Neighborhood Hits	1580	Target Neighborhood Hits	901	Shared Neighborhood Hits	801
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

MK14_HUMAN
θ value	2.69671e-12 (rank : 430)	NC score	0.805503 (rank : 407)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	805
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

NLK_HUMAN
θ value	2.69671e-12 (rank : 431)	NC score	0.798257 (rank : 440)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	806
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

NLK_MOUSE
θ value	2.69671e-12 (rank : 432)	NC score	0.798285 (rank : 439)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	806
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

VAV2_MOUSE
θ value	2.69671e-12 (rank : 433)	NC score	0.237074 (rank : 863)
Query Neighborhood Hits	1580	Target Neighborhood Hits	456	Shared Neighborhood Hits	196
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

DNMBP_MOUSE
θ value	3.52202e-12 (rank : 434)	NC score	0.209764 (rank : 885)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	190
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

MK11_MOUSE
θ value	3.52202e-12 (rank : 435)	NC score	0.800739 (rank : 426)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	801
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

MK12_HUMAN
θ value	3.52202e-12 (rank : 436)	NC score	0.807837 (rank : 386)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	799
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MYO3A_MOUSE
θ value	3.52202e-12 (rank : 437)	NC score	0.746195 (rank : 559)
Query Neighborhood Hits	1580	Target Neighborhood Hits	902	Shared Neighborhood Hits	835
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

M3K10_HUMAN
θ value	4.59992e-12 (rank : 438)	NC score	0.764006 (rank : 538)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1071	Shared Neighborhood Hits	896
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

FARP2_HUMAN
θ value	6.00763e-12 (rank : 439)	NC score	0.142602 (rank : 1098)
Query Neighborhood Hits	1580	Target Neighborhood Hits	240	Shared Neighborhood Hits	95
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FGD6_HUMAN
θ value	6.00763e-12 (rank : 440)	NC score	0.185738 (rank : 937)
Query Neighborhood Hits	1580	Target Neighborhood Hits	237	Shared Neighborhood Hits	92
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PMYT1_HUMAN
θ value	6.00763e-12 (rank : 441)	NC score	0.819201 (rank : 351)
Query Neighborhood Hits	1580	Target Neighborhood Hits	814	Shared Neighborhood Hits	778
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PMYT1_MOUSE
θ value	6.00763e-12 (rank : 442)	NC score	0.823298 (rank : 332)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	800
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

PRP4B_HUMAN
θ value	6.00763e-12 (rank : 443)	NC score	0.775981 (rank : 516)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1030	Shared Neighborhood Hits	823
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

PRP4B_MOUSE
θ value	6.00763e-12 (rank : 444)	NC score	0.774936 (rank : 519)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1040	Shared Neighborhood Hits	831
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

TAOK1_MOUSE
θ value	6.00763e-12 (rank : 445)	NC score	0.797720 (rank : 443)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1720	Shared Neighborhood Hits	1071
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK2_HUMAN
θ value	6.00763e-12 (rank : 446)	NC score	0.805871 (rank : 403)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1172	Shared Neighborhood Hits	969
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

TAOK2_MOUSE
θ value	6.00763e-12 (rank : 447)	NC score	0.806019 (rank : 402)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1373	Shared Neighborhood Hits	1030
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

CSK22_MOUSE
θ value	7.84624e-12 (rank : 448)	NC score	0.799158 (rank : 435)
Query Neighborhood Hits	1580	Target Neighborhood Hits	758	Shared Neighborhood Hits	739
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

M3K8_HUMAN
θ value	7.84624e-12 (rank : 449)	NC score	0.825725 (rank : 317)
Query Neighborhood Hits	1580	Target Neighborhood Hits	807	Shared Neighborhood Hits	785
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MK07_MOUSE
θ value	7.84624e-12 (rank : 450)	NC score	0.796382 (rank : 455)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1054	Shared Neighborhood Hits	839
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK08_HUMAN
θ value	7.84624e-12 (rank : 451)	NC score	0.799553 (rank : 433)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	805
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MK08_MOUSE
θ value	7.84624e-12 (rank : 452)	NC score	0.800144 (rank : 429)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	805
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

CSK22_HUMAN
θ value	1.02475e-11 (rank : 453)	NC score	0.799126 (rank : 436)
Query Neighborhood Hits	1580	Target Neighborhood Hits	758	Shared Neighborhood Hits	739
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

DYRK4_HUMAN
θ value	1.02475e-11 (rank : 454)	NC score	0.784554 (rank : 498)
Query Neighborhood Hits	1580	Target Neighborhood Hits	750	Shared Neighborhood Hits	732
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

MK07_HUMAN
θ value	1.02475e-11 (rank : 455)	NC score	0.795789 (rank : 458)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1087	Shared Neighborhood Hits	849
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

TAOK1_HUMAN
θ value	1.02475e-11 (rank : 456)	NC score	0.797500 (rank : 444)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1734	Shared Neighborhood Hits	1074
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

ARHG8_HUMAN
θ value	1.33837e-11 (rank : 457)	NC score	0.199457 (rank : 894)
Query Neighborhood Hits	1580	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

MK13_MOUSE
θ value	1.33837e-11 (rank : 458)	NC score	0.804756 (rank : 414)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	801
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

NEK11_MOUSE
θ value	1.33837e-11 (rank : 459)	NC score	0.836886 (rank : 267)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	825
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TXK_MOUSE
θ value	1.33837e-11 (rank : 460)	NC score	0.675272 (rank : 632)
Query Neighborhood Hits	1580	Target Neighborhood Hits	980	Shared Neighborhood Hits	822
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

MACF1_HUMAN
θ value	1.74796e-11 (rank : 461)	NC score	0.184800 (rank : 943)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1341	Shared Neighborhood Hits	377
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

MK10_HUMAN
θ value	1.74796e-11 (rank : 462)	NC score	0.797398 (rank : 445)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	805
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

GSK3A_HUMAN
θ value	2.28291e-11 (rank : 463)	NC score	0.808601 (rank : 385)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	783
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

ICK_HUMAN
θ value	2.28291e-11 (rank : 464)	NC score	0.810913 (rank : 375)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	807
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

ICK_MOUSE
θ value	2.28291e-11 (rank : 465)	NC score	0.811756 (rank : 371)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	810
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MACF4_HUMAN
θ value	2.28291e-11 (rank : 466)	NC score	0.193787 (rank : 912)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1321	Shared Neighborhood Hits	365
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

MLTK_HUMAN
θ value	2.28291e-11 (rank : 467)	NC score	0.749233 (rank : 555)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	811
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MP2K5_MOUSE
θ value	2.28291e-11 (rank : 468)	NC score	0.817860 (rank : 355)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	808
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

NEK11_HUMAN
θ value	2.28291e-11 (rank : 469)	NC score	0.837409 (rank : 265)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1043	Shared Neighborhood Hits	901
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

MK10_MOUSE
θ value	2.98157e-11 (rank : 470)	NC score	0.796862 (rank : 450)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	806
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MK13_HUMAN
θ value	2.98157e-11 (rank : 471)	NC score	0.803171 (rank : 417)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	800
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MLTK_MOUSE
θ value	2.98157e-11 (rank : 472)	NC score	0.749846 (rank : 553)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	807
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

NEK2_HUMAN
θ value	2.98157e-11 (rank : 473)	NC score	0.847047 (rank : 202)
Query Neighborhood Hits	1580	Target Neighborhood Hits	908	Shared Neighborhood Hits	839
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

BMP2K_HUMAN
θ value	3.89403e-11 (rank : 474)	NC score	0.788621 (rank : 486)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	772
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

BMX_MOUSE
θ value	5.08577e-11 (rank : 475)	NC score	0.679590 (rank : 623)
Query Neighborhood Hits	1580	Target Neighborhood Hits	912	Shared Neighborhood Hits	786
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

M3K8_MOUSE
θ value	5.08577e-11 (rank : 476)	NC score	0.825614 (rank : 319)
Query Neighborhood Hits	1580	Target Neighborhood Hits	815	Shared Neighborhood Hits	788
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

WNK1_HUMAN
θ value	5.08577e-11 (rank : 477)	NC score	0.791541 (rank : 476)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1158	Shared Neighborhood Hits	821
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	5.08577e-11 (rank : 478)	NC score	0.789751 (rank : 480)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1179	Shared Neighborhood Hits	809
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK3_HUMAN
θ value	5.08577e-11 (rank : 479)	NC score	0.800528 (rank : 427)
Query Neighborhood Hits	1580	Target Neighborhood Hits	948	Shared Neighborhood Hits	771
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

IKKE_HUMAN
θ value	6.64225e-11 (rank : 480)	NC score	0.835547 (rank : 275)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	802
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

MK09_HUMAN
θ value	6.64225e-11 (rank : 481)	NC score	0.804657 (rank : 415)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	808
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

BMX_HUMAN
θ value	8.67504e-11 (rank : 482)	NC score	0.680022 (rank : 621)
Query Neighborhood Hits	1580	Target Neighborhood Hits	942	Shared Neighborhood Hits	794
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

IKKE_MOUSE
θ value	8.67504e-11 (rank : 483)	NC score	0.833887 (rank : 286)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	811
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

ACK1_HUMAN
θ value	1.133e-10 (rank : 484)	NC score	0.647294 (rank : 669)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1140	Shared Neighborhood Hits	837
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

BLK_MOUSE
θ value	1.133e-10 (rank : 485)	NC score	0.667675 (rank : 644)
Query Neighborhood Hits	1580	Target Neighborhood Hits	992	Shared Neighborhood Hits	844
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CDK5_HUMAN
θ value	1.133e-10 (rank : 486)	NC score	0.805401 (rank : 408)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	793
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK5_MOUSE
θ value	1.133e-10 (rank : 487)	NC score	0.805190 (rank : 411)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	793
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

MP2K5_HUMAN
θ value	1.133e-10 (rank : 488)	NC score	0.813374 (rank : 364)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	804
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

SPTN2_HUMAN
θ value	1.133e-10 (rank : 489)	NC score	0.169950 (rank : 990)
Query Neighborhood Hits	1580	Target Neighborhood Hits	535	Shared Neighborhood Hits	237
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

BMP2K_MOUSE
θ value	1.47974e-10 (rank : 490)	NC score	0.788958 (rank : 483)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	774
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CLK1_HUMAN
θ value	1.47974e-10 (rank : 491)	NC score	0.773338 (rank : 520)
Query Neighborhood Hits	1580	Target Neighborhood Hits	756	Shared Neighborhood Hits	736
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

TNIK_HUMAN
θ value	1.47974e-10 (rank : 492)	NC score	0.810884 (rank : 376)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1570	Shared Neighborhood Hits	1032
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TXK_HUMAN
θ value	1.47974e-10 (rank : 493)	NC score	0.686242 (rank : 605)
Query Neighborhood Hits	1580	Target Neighborhood Hits	971	Shared Neighborhood Hits	828
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ARHGA_HUMAN
θ value	1.9326e-10 (rank : 494)	NC score	0.192123 (rank : 916)
Query Neighborhood Hits	1580	Target Neighborhood Hits	187	Shared Neighborhood Hits	96
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

MACF1_MOUSE
θ value	1.9326e-10 (rank : 495)	NC score	0.179496 (rank : 971)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1313	Shared Neighborhood Hits	367
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MINK1_HUMAN
θ value	1.9326e-10 (rank : 496)	NC score	0.806924 (rank : 395)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1477	Shared Neighborhood Hits	1029
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MINK1_MOUSE
θ value	1.9326e-10 (rank : 497)	NC score	0.807246 (rank : 391)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1451	Shared Neighborhood Hits	1018
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

BTK_HUMAN
θ value	2.52405e-10 (rank : 498)	NC score	0.685017 (rank : 610)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1026	Shared Neighborhood Hits	838
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	2.52405e-10 (rank : 499)	NC score	0.683533 (rank : 613)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1017	Shared Neighborhood Hits	835
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CDK4_HUMAN
θ value	2.52405e-10 (rank : 500)	NC score	0.794005 (rank : 468)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	800
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

JAK3_HUMAN
θ value	2.52405e-10 (rank : 501)	NC score	0.712286 (rank : 578)
Query Neighborhood Hits	1580	Target Neighborhood Hits	827	Shared Neighborhood Hits	796
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

M3K7_MOUSE
θ value	2.52405e-10 (rank : 502)	NC score	0.771223 (rank : 527)
Query Neighborhood Hits	1580	Target Neighborhood Hits	892	Shared Neighborhood Hits	835
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MK09_MOUSE
θ value	2.52405e-10 (rank : 503)	NC score	0.800163 (rank : 428)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	806
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

YES_HUMAN
θ value	2.52405e-10 (rank : 504)	NC score	0.658423 (rank : 655)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1059	Shared Neighborhood Hits	840
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHG3_HUMAN
θ value	3.29651e-10 (rank : 505)	NC score	0.198488 (rank : 899)
Query Neighborhood Hits	1580	Target Neighborhood Hits	82	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

DYR1B_HUMAN
θ value	3.29651e-10 (rank : 506)	NC score	0.789543 (rank : 481)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	763
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

FARP1_HUMAN
θ value	3.29651e-10 (rank : 507)	NC score	0.128501 (rank : 1218)
Query Neighborhood Hits	1580	Target Neighborhood Hits	241	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

LCK_MOUSE
θ value	3.29651e-10 (rank : 508)	NC score	0.668029 (rank : 642)
Query Neighborhood Hits	1580	Target Neighborhood Hits	981	Shared Neighborhood Hits	833
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

M4K5_MOUSE
θ value	3.29651e-10 (rank : 509)	NC score	0.807155 (rank : 392)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	797
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

MK11_HUMAN
θ value	3.29651e-10 (rank : 510)	NC score	0.793048 (rank : 471)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	798
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

TEC_MOUSE
θ value	3.29651e-10 (rank : 511)	NC score	0.695069 (rank : 594)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1006	Shared Neighborhood Hits	836
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

YES_MOUSE
θ value	3.29651e-10 (rank : 512)	NC score	0.657984 (rank : 656)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1052	Shared Neighborhood Hits	835
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

M4K5_HUMAN
θ value	4.30538e-10 (rank : 513)	NC score	0.806040 (rank : 401)
Query Neighborhood Hits	1580	Target Neighborhood Hits	845	Shared Neighborhood Hits	800
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

MOK_MOUSE
θ value	4.30538e-10 (rank : 514)	NC score	0.796818 (rank : 451)
Query Neighborhood Hits	1580	Target Neighborhood Hits	796	Shared Neighborhood Hits	774
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

SRMS_MOUSE
θ value	4.30538e-10 (rank : 515)	NC score	0.676918 (rank : 627)
Query Neighborhood Hits	1580	Target Neighborhood Hits	964	Shared Neighborhood Hits	827
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TEC_HUMAN
θ value	4.30538e-10 (rank : 516)	NC score	0.690345 (rank : 599)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1006	Shared Neighborhood Hits	837
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BLK_HUMAN
θ value	5.62301e-10 (rank : 517)	NC score	0.668920 (rank : 640)
Query Neighborhood Hits	1580	Target Neighborhood Hits	994	Shared Neighborhood Hits	846
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CLK1_MOUSE
θ value	5.62301e-10 (rank : 518)	NC score	0.772161 (rank : 523)
Query Neighborhood Hits	1580	Target Neighborhood Hits	760	Shared Neighborhood Hits	742
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

DYR1B_MOUSE
θ value	5.62301e-10 (rank : 519)	NC score	0.793174 (rank : 470)
Query Neighborhood Hits	1580	Target Neighborhood Hits	799	Shared Neighborhood Hits	761
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

NEK2_MOUSE
θ value	5.62301e-10 (rank : 520)	NC score	0.846780 (rank : 203)
Query Neighborhood Hits	1580	Target Neighborhood Hits	876	Shared Neighborhood Hits	814
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

NRK_HUMAN
θ value	5.62301e-10 (rank : 521)	NC score	0.802503 (rank : 422)
Query Neighborhood Hits	1580	Target Neighborhood Hits	931	Shared Neighborhood Hits	823
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

WNK2_HUMAN
θ value	5.62301e-10 (rank : 522)	NC score	0.780720 (rank : 510)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1407	Shared Neighborhood Hits	814
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

CCRK_HUMAN
θ value	7.34386e-10 (rank : 523)	NC score	0.805573 (rank : 406)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	803
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

DYRK3_HUMAN
θ value	7.34386e-10 (rank : 524)	NC score	0.796605 (rank : 453)
Query Neighborhood Hits	1580	Target Neighborhood Hits	798	Shared Neighborhood Hits	772
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

ITK_HUMAN
θ value	7.34386e-10 (rank : 525)	NC score	0.683024 (rank : 614)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1016	Shared Neighborhood Hits	846
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

LYN_MOUSE
θ value	7.34386e-10 (rank : 526)	NC score	0.681337 (rank : 618)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1023	Shared Neighborhood Hits	851
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3K7_HUMAN
θ value	7.34386e-10 (rank : 527)	NC score	0.770812 (rank : 528)
Query Neighborhood Hits	1580	Target Neighborhood Hits	892	Shared Neighborhood Hits	833
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

MK03_HUMAN
θ value	7.34386e-10 (rank : 528)	NC score	0.796308 (rank : 456)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	803
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

NEK4_HUMAN
θ value	7.34386e-10 (rank : 529)	NC score	0.837938 (rank : 264)
Query Neighborhood Hits	1580	Target Neighborhood Hits	883	Shared Neighborhood Hits	817
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

GSK3B_HUMAN
θ value	9.59137e-10 (rank : 530)	NC score	0.806203 (rank : 399)
Query Neighborhood Hits	1580	Target Neighborhood Hits	801	Shared Neighborhood Hits	777
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
θ value	9.59137e-10 (rank : 531)	NC score	0.806200 (rank : 400)
Query Neighborhood Hits	1580	Target Neighborhood Hits	800	Shared Neighborhood Hits	776
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

LCK_HUMAN
θ value	9.59137e-10 (rank : 532)	NC score	0.662735 (rank : 649)
Query Neighborhood Hits	1580	Target Neighborhood Hits	987	Shared Neighborhood Hits	835
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

MK03_MOUSE
θ value	9.59137e-10 (rank : 533)	NC score	0.796590 (rank : 454)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	803
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

VAV3_MOUSE
θ value	9.59137e-10 (rank : 534)	NC score	0.238956 (rank : 862)
Query Neighborhood Hits	1580	Target Neighborhood Hits	404	Shared Neighborhood Hits	186
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ACK1_MOUSE
θ value	1.25267e-09 (rank : 535)	NC score	0.645873 (rank : 670)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1080	Shared Neighborhood Hits	832
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

ARHG8_MOUSE
θ value	1.25267e-09 (rank : 536)	NC score	0.192760 (rank : 915)
Query Neighborhood Hits	1580	Target Neighborhood Hits	79	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

DMD_MOUSE
θ value	1.25267e-09 (rank : 537)	NC score	0.178576 (rank : 976)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1111	Shared Neighborhood Hits	339
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

FYN_MOUSE
θ value	1.25267e-09 (rank : 538)	NC score	0.664889 (rank : 648)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1073	Shared Neighborhood Hits	854
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

ITK_MOUSE
θ value	1.25267e-09 (rank : 539)	NC score	0.681847 (rank : 617)
Query Neighborhood Hits	1580	Target Neighborhood Hits	985	Shared Neighborhood Hits	839
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LYN_HUMAN
θ value	1.25267e-09 (rank : 540)	NC score	0.681023 (rank : 620)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1022	Shared Neighborhood Hits	853
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MASTL_HUMAN
θ value	1.25267e-09 (rank : 541)	NC score	0.831140 (rank : 296)
Query Neighborhood Hits	1580	Target Neighborhood Hits	894	Shared Neighborhood Hits	814
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MK04_MOUSE
θ value	1.25267e-09 (rank : 542)	NC score	0.796648 (rank : 452)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	793
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

SYNE1_HUMAN
θ value	1.25267e-09 (rank : 543)	NC score	0.184711 (rank : 945)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1484	Shared Neighborhood Hits	393
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CSK_MOUSE
θ value	1.63604e-09 (rank : 544)	NC score	0.691797 (rank : 596)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	839
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

M4K2_MOUSE
θ value	1.63604e-09 (rank : 545)	NC score	0.811927 (rank : 369)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	806
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

M4K4_HUMAN
θ value	1.63604e-09 (rank : 546)	NC score	0.802516 (rank : 421)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1589	Shared Neighborhood Hits	1047
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

MOK_HUMAN
θ value	1.63604e-09 (rank : 547)	NC score	0.798157 (rank : 442)
Query Neighborhood Hits	1580	Target Neighborhood Hits	807	Shared Neighborhood Hits	777
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

MYH6_MOUSE
θ value	1.63604e-09 (rank : 548)	NC score	0.141371 (rank : 1114)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1501	Shared Neighborhood Hits	369
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

STK35_HUMAN
θ value	1.63604e-09 (rank : 549)	NC score	0.822309 (rank : 333)
Query Neighborhood Hits	1580	Target Neighborhood Hits	825	Shared Neighborhood Hits	794
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

ARHG3_MOUSE
θ value	2.13673e-09 (rank : 550)	NC score	0.195731 (rank : 905)
Query Neighborhood Hits	1580	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

CSK_HUMAN
θ value	2.13673e-09 (rank : 551)	NC score	0.684107 (rank : 611)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	838
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

DYR1A_HUMAN
θ value	2.13673e-09 (rank : 552)	NC score	0.782083 (rank : 506)
Query Neighborhood Hits	1580	Target Neighborhood Hits	764	Shared Neighborhood Hits	745
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

DYR1A_MOUSE
θ value	2.13673e-09 (rank : 553)	NC score	0.782086 (rank : 505)
Query Neighborhood Hits	1580	Target Neighborhood Hits	762	Shared Neighborhood Hits	744
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

E2AK4_HUMAN
θ value	2.13673e-09 (rank : 554)	NC score	0.788763 (rank : 484)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1012	Shared Neighborhood Hits	862
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

STK40_HUMAN
θ value	2.13673e-09 (rank : 555)	NC score	0.826664 (rank : 311)
Query Neighborhood Hits	1580	Target Neighborhood Hits	751	Shared Neighborhood Hits	729
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

STK40_MOUSE
θ value	2.13673e-09 (rank : 556)	NC score	0.826416 (rank : 313)
Query Neighborhood Hits	1580	Target Neighborhood Hits	751	Shared Neighborhood Hits	729
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

TTK_HUMAN
θ value	2.13673e-09 (rank : 557)	NC score	0.832762 (rank : 290)
Query Neighborhood Hits	1580	Target Neighborhood Hits	816	Shared Neighborhood Hits	761
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

CCRK_MOUSE
θ value	2.79066e-09 (rank : 558)	NC score	0.804874 (rank : 412)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	801
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CDK4_MOUSE
θ value	2.79066e-09 (rank : 559)	NC score	0.794513 (rank : 462)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	802
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

MATK_MOUSE
θ value	2.79066e-09 (rank : 560)	NC score	0.677371 (rank : 626)
Query Neighborhood Hits	1580	Target Neighborhood Hits	952	Shared Neighborhood Hits	819
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

TTK_MOUSE
θ value	2.79066e-09 (rank : 561)	NC score	0.830668 (rank : 297)
Query Neighborhood Hits	1580	Target Neighborhood Hits	803	Shared Neighborhood Hits	744
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

AAK1_HUMAN
θ value	3.64472e-09 (rank : 562)	NC score	0.781100 (rank : 509)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1077	Shared Neighborhood Hits	806
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

FGD5_HUMAN
θ value	3.64472e-09 (rank : 563)	NC score	0.159320 (rank : 1005)
Query Neighborhood Hits	1580	Target Neighborhood Hits	235	Shared Neighborhood Hits	76
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

M3K9_HUMAN
θ value	3.64472e-09 (rank : 564)	NC score	0.765458 (rank : 534)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1123	Shared Neighborhood Hits	896
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M4K2_HUMAN
θ value	3.64472e-09 (rank : 565)	NC score	0.811449 (rank : 374)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	808
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

ROR2_HUMAN
θ value	3.64472e-09 (rank : 566)	NC score	0.643200 (rank : 677)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1014	Shared Neighborhood Hits	925
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

SRMS_HUMAN
θ value	3.64472e-09 (rank : 567)	NC score	0.671111 (rank : 637)
Query Neighborhood Hits	1580	Target Neighborhood Hits	946	Shared Neighborhood Hits	821
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

WNK4_MOUSE
θ value	3.64472e-09 (rank : 568)	NC score	0.789993 (rank : 479)
Query Neighborhood Hits	1580	Target Neighborhood Hits	961	Shared Neighborhood Hits	771
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ITSN1_HUMAN
θ value	4.76016e-09 (rank : 569)	NC score	0.228624 (rank : 871)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1757	Shared Neighborhood Hits	492
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_HUMAN
θ value	4.76016e-09 (rank : 570)	NC score	0.233124 (rank : 864)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1173	Shared Neighborhood Hits	420
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

M3KL4_HUMAN
θ value	4.76016e-09 (rank : 571)	NC score	0.756673 (rank : 545)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1087	Shared Neighborhood Hits	911
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MK01_HUMAN
θ value	4.76016e-09 (rank : 572)	NC score	0.794474 (rank : 463)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	801
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

RIPK1_HUMAN
θ value	4.76016e-09 (rank : 573)	NC score	0.766341 (rank : 532)
Query Neighborhood Hits	1580	Target Neighborhood Hits	891	Shared Neighborhood Hits	813
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

SRC_MOUSE
θ value	4.76016e-09 (rank : 574)	NC score	0.660762 (rank : 653)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1033	Shared Neighborhood Hits	836
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

WNK4_HUMAN
θ value	4.76016e-09 (rank : 575)	NC score	0.786860 (rank : 490)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1043	Shared Neighborhood Hits	779
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

AAK1_MOUSE
θ value	6.21693e-09 (rank : 576)	NC score	0.780000 (rank : 511)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1051	Shared Neighborhood Hits	794
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

IRAK4_MOUSE
θ value	6.21693e-09 (rank : 577)	NC score	0.768047 (rank : 531)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	782
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

ITSN1_MOUSE
θ value	6.21693e-09 (rank : 578)	NC score	0.228514 (rank : 872)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1669	Shared Neighborhood Hits	490
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MASTL_MOUSE
θ value	6.21693e-09 (rank : 579)	NC score	0.829614 (rank : 301)
Query Neighborhood Hits	1580	Target Neighborhood Hits	862	Shared Neighborhood Hits	809
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

MK01_MOUSE
θ value	6.21693e-09 (rank : 580)	NC score	0.794334 (rank : 464)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	801
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK15_MOUSE
θ value	6.21693e-09 (rank : 581)	NC score	0.812337 (rank : 368)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	801
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

RAF1_HUMAN
θ value	6.21693e-09 (rank : 582)	NC score	0.752465 (rank : 549)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	819
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	6.21693e-09 (rank : 583)	NC score	0.753034 (rank : 548)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	820
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

SRC_HUMAN
θ value	6.21693e-09 (rank : 584)	NC score	0.661139 (rank : 652)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1058	Shared Neighborhood Hits	840
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

E2AK4_MOUSE
θ value	8.11959e-09 (rank : 585)	NC score	0.785138 (rank : 496)
Query Neighborhood Hits	1580	Target Neighborhood Hits	984	Shared Neighborhood Hits	845
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

ECT2_MOUSE
θ value	8.11959e-09 (rank : 586)	NC score	0.202455 (rank : 891)
Query Neighborhood Hits	1580	Target Neighborhood Hits	98	Shared Neighborhood Hits	77
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

M4K4_MOUSE
θ value	8.11959e-09 (rank : 587)	NC score	0.794039 (rank : 467)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1560	Shared Neighborhood Hits	1036
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

NEK4_MOUSE
θ value	8.11959e-09 (rank : 588)	NC score	0.839417 (rank : 255)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	820
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

CLK3_HUMAN
θ value	1.06045e-08 (rank : 589)	NC score	0.740925 (rank : 563)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	728
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

CLK3_MOUSE
θ value	1.06045e-08 (rank : 590)	NC score	0.740290 (rank : 565)
Query Neighborhood Hits	1580	Target Neighborhood Hits	761	Shared Neighborhood Hits	728
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

JAK2_MOUSE
θ value	1.06045e-08 (rank : 591)	NC score	0.714814 (rank : 576)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	800
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

VAV3_HUMAN
θ value	1.06045e-08 (rank : 592)	NC score	0.239471 (rank : 859)
Query Neighborhood Hits	1580	Target Neighborhood Hits	398	Shared Neighborhood Hits	184
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

WEE1_MOUSE
θ value	1.06045e-08 (rank : 593)	NC score	0.783566 (rank : 501)
Query Neighborhood Hits	1580	Target Neighborhood Hits	794	Shared Neighborhood Hits	746
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

BRAF1_HUMAN
θ value	1.38499e-08 (rank : 594)	NC score	0.752364 (rank : 550)
Query Neighborhood Hits	1580	Target Neighborhood Hits	883	Shared Neighborhood Hits	817
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

FES_HUMAN
θ value	1.38499e-08 (rank : 595)	NC score	0.703089 (rank : 587)
Query Neighborhood Hits	1580	Target Neighborhood Hits	978	Shared Neighborhood Hits	836
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	1.38499e-08 (rank : 596)	NC score	0.705116 (rank : 584)
Query Neighborhood Hits	1580	Target Neighborhood Hits	980	Shared Neighborhood Hits	860
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

GOGA4_HUMAN
θ value	1.38499e-08 (rank : 597)	NC score	0.158992 (rank : 1007)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2034	Shared Neighborhood Hits	421
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

JAK3_MOUSE
θ value	1.38499e-08 (rank : 598)	NC score	0.718586 (rank : 574)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	789
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

NGL1_HUMAN
θ value	1.38499e-08 (rank : 599)	NC score	0.092522 (rank : 1503)
Query Neighborhood Hits	1580	Target Neighborhood Hits	511	Shared Neighborhood Hits	208
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_MOUSE
θ value	1.38499e-08 (rank : 600)	NC score	0.092528 (rank : 1502)
Query Neighborhood Hits	1580	Target Neighborhood Hits	512	Shared Neighborhood Hits	208
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

IRAK4_HUMAN
θ value	1.80886e-08 (rank : 601)	NC score	0.760320 (rank : 543)
Query Neighborhood Hits	1580	Target Neighborhood Hits	816	Shared Neighborhood Hits	784
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

MATK_HUMAN
θ value	1.80886e-08 (rank : 602)	NC score	0.673436 (rank : 634)
Query Neighborhood Hits	1580	Target Neighborhood Hits	954	Shared Neighborhood Hits	820
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

NRK_MOUSE
θ value	1.80886e-08 (rank : 603)	NC score	0.800039 (rank : 430)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	818
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

CDK10_HUMAN
θ value	2.36244e-08 (rank : 604)	NC score	0.790054 (rank : 477)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	803
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

CLK4_HUMAN
θ value	2.36244e-08 (rank : 605)	NC score	0.766224 (rank : 533)
Query Neighborhood Hits	1580	Target Neighborhood Hits	759	Shared Neighborhood Hits	740
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

CLK4_MOUSE
θ value	2.36244e-08 (rank : 606)	NC score	0.764832 (rank : 536)
Query Neighborhood Hits	1580	Target Neighborhood Hits	759	Shared Neighborhood Hits	740
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

FYN_HUMAN
θ value	2.36244e-08 (rank : 607)	NC score	0.668726 (rank : 641)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1078	Shared Neighborhood Hits	852
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

JAK2_HUMAN
θ value	2.36244e-08 (rank : 608)	NC score	0.715683 (rank : 575)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	804
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

MYH7_HUMAN
θ value	2.36244e-08 (rank : 609)	NC score	0.141097 (rank : 1120)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1559	Shared Neighborhood Hits	365
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

AL2S7_HUMAN
θ value	3.08544e-08 (rank : 610)	NC score	0.799812 (rank : 432)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	795
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

ARHGA_MOUSE
θ value	3.08544e-08 (rank : 611)	NC score	0.186588 (rank : 934)
Query Neighborhood Hits	1580	Target Neighborhood Hits	125	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ECT2_HUMAN
θ value	3.08544e-08 (rank : 612)	NC score	0.197513 (rank : 902)
Query Neighborhood Hits	1580	Target Neighborhood Hits	98	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

FGD5_MOUSE
θ value	3.08544e-08 (rank : 613)	NC score	0.154519 (rank : 1021)
Query Neighborhood Hits	1580	Target Neighborhood Hits	170	Shared Neighborhood Hits	71
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

LRC4B_HUMAN
θ value	3.08544e-08 (rank : 614)	NC score	0.093862 (rank : 1488)
Query Neighborhood Hits	1580	Target Neighborhood Hits	479	Shared Neighborhood Hits	205
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

LRC4B_MOUSE
θ value	3.08544e-08 (rank : 615)	NC score	0.094211 (rank : 1484)
Query Neighborhood Hits	1580	Target Neighborhood Hits	484	Shared Neighborhood Hits	205
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

M3K11_HUMAN
θ value	3.08544e-08 (rank : 616)	NC score	0.765177 (rank : 535)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1136	Shared Neighborhood Hits	898
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

ZAP70_HUMAN
θ value	3.08544e-08 (rank : 617)	NC score	0.687857 (rank : 604)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	800
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CDK8_HUMAN
θ value	4.0297e-08 (rank : 618)	NC score	0.779637 (rank : 512)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	794
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

E2AK1_HUMAN
θ value	4.0297e-08 (rank : 619)	NC score	0.795335 (rank : 460)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	800
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

LRRN1_HUMAN
θ value	4.0297e-08 (rank : 620)	NC score	0.107230 (rank : 1394)
Query Neighborhood Hits	1580	Target Neighborhood Hits	518	Shared Neighborhood Hits	221
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

GCC2_HUMAN
θ value	5.26297e-08 (rank : 621)	NC score	0.150455 (rank : 1040)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1558	Shared Neighborhood Hits	372
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

ITSN2_MOUSE
θ value	5.26297e-08 (rank : 622)	NC score	0.229548 (rank : 870)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1371	Shared Neighborhood Hits	447
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

LRRN1_MOUSE
θ value	5.26297e-08 (rank : 623)	NC score	0.104173 (rank : 1413)
Query Neighborhood Hits	1580	Target Neighborhood Hits	508	Shared Neighborhood Hits	220
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

PTK6_MOUSE
θ value	5.26297e-08 (rank : 624)	NC score	0.702355 (rank : 588)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1026	Shared Neighborhood Hits	847
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

RBP24_HUMAN
θ value	5.26297e-08 (rank : 625)	NC score	0.150132 (rank : 1043)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1559	Shared Neighborhood Hits	372
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

SDK1_HUMAN
θ value	5.26297e-08 (rank : 626)	NC score	0.190391 (rank : 925)
Query Neighborhood Hits	1580	Target Neighborhood Hits	511	Shared Neighborhood Hits	283
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

ANPRB_HUMAN
θ value	6.87365e-08 (rank : 627)	NC score	0.433941 (rank : 826)
Query Neighborhood Hits	1580	Target Neighborhood Hits	646	Shared Neighborhood Hits	568
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

FRK_HUMAN
θ value	6.87365e-08 (rank : 628)	NC score	0.679857 (rank : 622)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1058	Shared Neighborhood Hits	850
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

MK04_HUMAN
θ value	6.87365e-08 (rank : 629)	NC score	0.797138 (rank : 448)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	797
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

ZAP70_MOUSE
θ value	6.87365e-08 (rank : 630)	NC score	0.685758 (rank : 606)
Query Neighborhood Hits	1580	Target Neighborhood Hits	905	Shared Neighborhood Hits	808
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CLK2_HUMAN
θ value	8.97725e-08 (rank : 631)	NC score	0.763692 (rank : 539)
Query Neighborhood Hits	1580	Target Neighborhood Hits	752	Shared Neighborhood Hits	733
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

EEA1_MOUSE
θ value	8.97725e-08 (rank : 632)	NC score	0.162568 (rank : 1000)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1637	Shared Neighborhood Hits	395
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

EPHB4_MOUSE
θ value	8.97725e-08 (rank : 633)	NC score	0.639376 (rank : 685)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1013	Shared Neighborhood Hits	838
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

FGR_HUMAN
θ value	8.97725e-08 (rank : 634)	NC score	0.653162 (rank : 663)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1067	Shared Neighborhood Hits	843
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

HOOK1_HUMAN
θ value	8.97725e-08 (rank : 635)	NC score	0.148990 (rank : 1053)
Query Neighborhood Hits	1580	Target Neighborhood Hits	942	Shared Neighborhood Hits	318
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

PUNC_HUMAN
θ value	8.97725e-08 (rank : 636)	NC score	0.194793 (rank : 909)
Query Neighborhood Hits	1580	Target Neighborhood Hits	449	Shared Neighborhood Hits	248
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

BOC_MOUSE
θ value	1.17247e-07 (rank : 637)	NC score	0.193172 (rank : 914)
Query Neighborhood Hits	1580	Target Neighborhood Hits	433	Shared Neighborhood Hits	262
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

CENPF_HUMAN
θ value	1.17247e-07 (rank : 638)	NC score	0.152809 (rank : 1030)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1932	Shared Neighborhood Hits	413
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

DMD_HUMAN
θ value	1.17247e-07 (rank : 639)	NC score	0.173674 (rank : 983)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1135	Shared Neighborhood Hits	342
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

E2AK2_MOUSE
θ value	1.17247e-07 (rank : 640)	NC score	0.828611 (rank : 305)
Query Neighborhood Hits	1580	Target Neighborhood Hits	864	Shared Neighborhood Hits	812
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

MP2K4_HUMAN
θ value	1.17247e-07 (rank : 641)	NC score	0.807427 (rank : 388)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	805
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
θ value	1.17247e-07 (rank : 642)	NC score	0.807272 (rank : 389)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	805
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

MP2K7_HUMAN
θ value	1.17247e-07 (rank : 643)	NC score	0.815415 (rank : 358)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	799
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

MYH13_HUMAN
θ value	1.17247e-07 (rank : 644)	NC score	0.139770 (rank : 1129)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1504	Shared Neighborhood Hits	359
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

PUNC_MOUSE
θ value	1.17247e-07 (rank : 645)	NC score	0.195213 (rank : 907)
Query Neighborhood Hits	1580	Target Neighborhood Hits	501	Shared Neighborhood Hits	257
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

CD2L6_HUMAN
θ value	1.53129e-07 (rank : 646)	NC score	0.782814 (rank : 503)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	799
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

CD2L6_MOUSE
θ value	1.53129e-07 (rank : 647)	NC score	0.783088 (rank : 502)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	804
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CDK9_HUMAN
θ value	1.53129e-07 (rank : 648)	NC score	0.788646 (rank : 485)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	791
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

CDK9_MOUSE
θ value	1.53129e-07 (rank : 649)	NC score	0.788034 (rank : 487)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	791
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

EPHB4_HUMAN
θ value	1.53129e-07 (rank : 650)	NC score	0.635650 (rank : 691)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1056	Shared Neighborhood Hits	842
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

F5006_HUMAN
θ value	1.53129e-07 (rank : 651)	NC score	0.824027 (rank : 330)
Query Neighborhood Hits	1580	Target Neighborhood Hits	794	Shared Neighborhood Hits	765
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

F5006_MOUSE
θ value	1.53129e-07 (rank : 652)	NC score	0.827441 (rank : 308)
Query Neighborhood Hits	1580	Target Neighborhood Hits	793	Shared Neighborhood Hits	767
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

HOOK1_MOUSE
θ value	1.53129e-07 (rank : 653)	NC score	0.148802 (rank : 1055)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	317
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

LRFN5_MOUSE
θ value	1.53129e-07 (rank : 654)	NC score	0.118012 (rank : 1308)
Query Neighborhood Hits	1580	Target Neighborhood Hits	472	Shared Neighborhood Hits	209
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

TBK1_MOUSE
θ value	1.53129e-07 (rank : 655)	NC score	0.838947 (rank : 260)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	843
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

CD2L7_HUMAN
θ value	1.99992e-07 (rank : 656)	NC score	0.795946 (rank : 457)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1275	Shared Neighborhood Hits	871
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

HCK_HUMAN
θ value	1.99992e-07 (rank : 657)	NC score	0.666442 (rank : 645)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1035	Shared Neighborhood Hits	850
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

SDK1_MOUSE
θ value	1.99992e-07 (rank : 658)	NC score	0.187556 (rank : 931)
Query Neighborhood Hits	1580	Target Neighborhood Hits	495	Shared Neighborhood Hits	278
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

BOC_HUMAN
θ value	2.61198e-07 (rank : 659)	NC score	0.191992 (rank : 917)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	273
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

ERN1_HUMAN
θ value	2.61198e-07 (rank : 660)	NC score	0.798475 (rank : 438)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	796
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

FAK2_MOUSE
θ value	2.61198e-07 (rank : 661)	NC score	0.670412 (rank : 638)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	786
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

MYH3_HUMAN
θ value	2.61198e-07 (rank : 662)	NC score	0.139446 (rank : 1133)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1660	Shared Neighborhood Hits	374
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

TBK1_HUMAN
θ value	2.61198e-07 (rank : 663)	NC score	0.836995 (rank : 266)
Query Neighborhood Hits	1580	Target Neighborhood Hits	861	Shared Neighborhood Hits	822
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

TIE1_MOUSE
θ value	2.61198e-07 (rank : 664)	NC score	0.639924 (rank : 683)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1266	Shared Neighborhood Hits	894
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TYK2_HUMAN
θ value	2.61198e-07 (rank : 665)	NC score	0.708721 (rank : 581)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	801
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

WEE1_HUMAN
θ value	2.61198e-07 (rank : 666)	NC score	0.772772 (rank : 522)
Query Neighborhood Hits	1580	Target Neighborhood Hits	777	Shared Neighborhood Hits	732
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

FAK2_HUMAN
θ value	3.41135e-07 (rank : 667)	NC score	0.665569 (rank : 647)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	787
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

LRFN5_HUMAN
θ value	3.41135e-07 (rank : 668)	NC score	0.116015 (rank : 1329)
Query Neighborhood Hits	1580	Target Neighborhood Hits	464	Shared Neighborhood Hits	207
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

MET_MOUSE
θ value	3.41135e-07 (rank : 669)	NC score	0.629398 (rank : 710)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	774
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MYH4_HUMAN
θ value	3.41135e-07 (rank : 670)	NC score	0.138429 (rank : 1136)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1377	Shared Neighborhood Hits	349
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

NEO1_MOUSE
θ value	3.41135e-07 (rank : 671)	NC score	0.196103 (rank : 904)
Query Neighborhood Hits	1580	Target Neighborhood Hits	523	Shared Neighborhood Hits	284
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

ROBO2_HUMAN
θ value	3.41135e-07 (rank : 672)	NC score	0.197959 (rank : 901)
Query Neighborhood Hits	1580	Target Neighborhood Hits	479	Shared Neighborhood Hits	270
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

EPHA1_HUMAN
θ value	4.45536e-07 (rank : 673)	NC score	0.625768 (rank : 723)
Query Neighborhood Hits	1580	Target Neighborhood Hits	997	Shared Neighborhood Hits	821
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

LIMK2_HUMAN
θ value	4.45536e-07 (rank : 674)	NC score	0.740701 (rank : 564)
Query Neighborhood Hits	1580	Target Neighborhood Hits	986	Shared Neighborhood Hits	798
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MYH10_MOUSE
θ value	4.45536e-07 (rank : 675)	NC score	0.141861 (rank : 1109)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1612	Shared Neighborhood Hits	383
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

RIPK1_MOUSE
θ value	4.45536e-07 (rank : 676)	NC score	0.757743 (rank : 544)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	810
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

E2AK1_MOUSE
θ value	5.81887e-07 (rank : 677)	NC score	0.799977 (rank : 431)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	793
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

EPHB1_HUMAN
θ value	5.81887e-07 (rank : 678)	NC score	0.645509 (rank : 672)
Query Neighborhood Hits	1580	Target Neighborhood Hits	988	Shared Neighborhood Hits	839
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB3_HUMAN
θ value	5.81887e-07 (rank : 679)	NC score	0.621830 (rank : 730)
Query Neighborhood Hits	1580	Target Neighborhood Hits	996	Shared Neighborhood Hits	847
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

FAK1_HUMAN
θ value	5.81887e-07 (rank : 680)	NC score	0.679168 (rank : 624)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	795
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	5.81887e-07 (rank : 681)	NC score	0.678750 (rank : 625)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	793
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

LRIG1_HUMAN
θ value	5.81887e-07 (rank : 682)	NC score	0.146573 (rank : 1070)
Query Neighborhood Hits	1580	Target Neighborhood Hits	654	Shared Neighborhood Hits	257
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MYH10_HUMAN
θ value	5.81887e-07 (rank : 683)	NC score	0.141875 (rank : 1108)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1620	Shared Neighborhood Hits	387
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

PDK1L_HUMAN
θ value	5.81887e-07 (rank : 684)	NC score	0.828935 (rank : 303)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	790
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
θ value	5.81887e-07 (rank : 685)	NC score	0.828770 (rank : 304)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	791
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

RIPK5_HUMAN
θ value	5.81887e-07 (rank : 686)	NC score	0.775782 (rank : 518)
Query Neighborhood Hits	1580	Target Neighborhood Hits	864	Shared Neighborhood Hits	822
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

RIPK5_MOUSE
θ value	5.81887e-07 (rank : 687)	NC score	0.775876 (rank : 517)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	828
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

TESK1_MOUSE
θ value	5.81887e-07 (rank : 688)	NC score	0.764510 (rank : 537)
Query Neighborhood Hits	1580	Target Neighborhood Hits	862	Shared Neighborhood Hits	792
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

ARHGC_HUMAN
θ value	7.59969e-07 (rank : 689)	NC score	0.156016 (rank : 1018)
Query Neighborhood Hits	1580	Target Neighborhood Hits	351	Shared Neighborhood Hits	128
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CD2L5_HUMAN
θ value	7.59969e-07 (rank : 690)	NC score	0.794669 (rank : 461)
Query Neighborhood Hits	1580	Target Neighborhood Hits	987	Shared Neighborhood Hits	815
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CD2L5_MOUSE
θ value	7.59969e-07 (rank : 691)	NC score	0.794260 (rank : 465)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1011	Shared Neighborhood Hits	813
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CLK2_MOUSE
θ value	7.59969e-07 (rank : 692)	NC score	0.751732 (rank : 552)
Query Neighborhood Hits	1580	Target Neighborhood Hits	743	Shared Neighborhood Hits	728
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

DCC_HUMAN
θ value	7.59969e-07 (rank : 693)	NC score	0.193224 (rank : 913)
Query Neighborhood Hits	1580	Target Neighborhood Hits	583	Shared Neighborhood Hits	290
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

DCC_MOUSE
θ value	7.59969e-07 (rank : 694)	NC score	0.191376 (rank : 921)
Query Neighborhood Hits	1580	Target Neighborhood Hits	896	Shared Neighborhood Hits	330
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

EPHA7_MOUSE
θ value	7.59969e-07 (rank : 695)	NC score	0.641571 (rank : 679)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1025	Shared Neighborhood Hits	848
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

FER_HUMAN
θ value	7.59969e-07 (rank : 696)	NC score	0.699912 (rank : 591)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1278	Shared Neighborhood Hits	981
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

LRIG2_HUMAN
θ value	7.59969e-07 (rank : 697)	NC score	0.146493 (rank : 1071)
Query Neighborhood Hits	1580	Target Neighborhood Hits	595	Shared Neighborhood Hits	250
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

MOS_HUMAN
θ value	7.59969e-07 (rank : 698)	NC score	0.749569 (rank : 554)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	805
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

PINK1_MOUSE
θ value	7.59969e-07 (rank : 699)	NC score	0.733670 (rank : 570)
Query Neighborhood Hits	1580	Target Neighborhood Hits	726	Shared Neighborhood Hits	703
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

PTK6_HUMAN
θ value	7.59969e-07 (rank : 700)	NC score	0.703628 (rank : 586)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1020	Shared Neighborhood Hits	844
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

ROBO2_MOUSE
θ value	7.59969e-07 (rank : 701)	NC score	0.198163 (rank : 900)
Query Neighborhood Hits	1580	Target Neighborhood Hits	504	Shared Neighborhood Hits	282
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROR2_MOUSE
θ value	7.59969e-07 (rank : 702)	NC score	0.619170 (rank : 735)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1000	Shared Neighborhood Hits	909
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

TIE1_HUMAN
θ value	7.59969e-07 (rank : 703)	NC score	0.635447 (rank : 692)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1241	Shared Neighborhood Hits	881
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

ANPRB_MOUSE
θ value	9.92553e-07 (rank : 704)	NC score	0.407017 (rank : 832)
Query Neighborhood Hits	1580	Target Neighborhood Hits	607	Shared Neighborhood Hits	543
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

CCD41_MOUSE
θ value	9.92553e-07 (rank : 705)	NC score	0.142196 (rank : 1103)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1399	Shared Neighborhood Hits	357
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

EPHA7_HUMAN
θ value	9.92553e-07 (rank : 706)	NC score	0.641334 (rank : 680)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1053	Shared Neighborhood Hits	851
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

ERN2_MOUSE
θ value	9.92553e-07 (rank : 707)	NC score	0.789382 (rank : 482)
Query Neighborhood Hits	1580	Target Neighborhood Hits	825	Shared Neighborhood Hits	792
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

HCK_MOUSE
θ value	9.92553e-07 (rank : 708)	NC score	0.662099 (rank : 650)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1029	Shared Neighborhood Hits	853
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HOOK3_MOUSE
θ value	9.92553e-07 (rank : 709)	NC score	0.141881 (rank : 1107)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1007	Shared Neighborhood Hits	317
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

LRRN3_HUMAN
θ value	9.92553e-07 (rank : 710)	NC score	0.110696 (rank : 1370)
Query Neighborhood Hits	1580	Target Neighborhood Hits	461	Shared Neighborhood Hits	203
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

LRRN5_HUMAN
θ value	9.92553e-07 (rank : 711)	NC score	0.101802 (rank : 1432)
Query Neighborhood Hits	1580	Target Neighborhood Hits	493	Shared Neighborhood Hits	216
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

MET_HUMAN
θ value	9.92553e-07 (rank : 712)	NC score	0.626578 (rank : 715)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	773
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MYH11_HUMAN
θ value	9.92553e-07 (rank : 713)	NC score	0.140508 (rank : 1123)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1806	Shared Neighborhood Hits	400
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

PINK1_HUMAN
θ value	9.92553e-07 (rank : 714)	NC score	0.729380 (rank : 573)
Query Neighborhood Hits	1580	Target Neighborhood Hits	741	Shared Neighborhood Hits	704
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

EPHB3_MOUSE
θ value	1.29631e-06 (rank : 715)	NC score	0.620408 (rank : 732)
Query Neighborhood Hits	1580	Target Neighborhood Hits	996	Shared Neighborhood Hits	847
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

FGR_MOUSE
θ value	1.29631e-06 (rank : 716)	NC score	0.649717 (rank : 666)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1069	Shared Neighborhood Hits	845
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

JAK1_HUMAN
θ value	1.29631e-06 (rank : 717)	NC score	0.697579 (rank : 593)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	805
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

LRIG2_MOUSE
θ value	1.29631e-06 (rank : 718)	NC score	0.145254 (rank : 1078)
Query Neighborhood Hits	1580	Target Neighborhood Hits	586	Shared Neighborhood Hits	247
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

LRRK1_MOUSE
θ value	1.29631e-06 (rank : 719)	NC score	0.708118 (rank : 583)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1267	Shared Neighborhood Hits	829
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

REST_MOUSE
θ value	1.29631e-06 (rank : 720)	NC score	0.147549 (rank : 1064)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1506	Shared Neighborhood Hits	364
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

TIE2_HUMAN
θ value	1.29631e-06 (rank : 721)	NC score	0.653796 (rank : 661)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1192	Shared Neighborhood Hits	864
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

ARAF_MOUSE
θ value	1.69304e-06 (rank : 722)	NC score	0.745835 (rank : 560)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	812
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ERN1_MOUSE
θ value	1.69304e-06 (rank : 723)	NC score	0.797323 (rank : 447)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	793
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

HMCN1_HUMAN
θ value	1.69304e-06 (rank : 724)	NC score	0.132146 (rank : 1192)
Query Neighborhood Hits	1580	Target Neighborhood Hits	983	Shared Neighborhood Hits	272
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

LIMK2_MOUSE
θ value	1.69304e-06 (rank : 725)	NC score	0.738133 (rank : 566)
Query Neighborhood Hits	1580	Target Neighborhood Hits	998	Shared Neighborhood Hits	798
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

LRRN3_MOUSE
θ value	1.69304e-06 (rank : 726)	NC score	0.104939 (rank : 1409)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	197
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

NEO1_HUMAN
θ value	1.69304e-06 (rank : 727)	NC score	0.195270 (rank : 906)
Query Neighborhood Hits	1580	Target Neighborhood Hits	530	Shared Neighborhood Hits	279
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

TIE2_MOUSE
θ value	1.69304e-06 (rank : 728)	NC score	0.653279 (rank : 662)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1204	Shared Neighborhood Hits	865
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TRIB2_HUMAN
θ value	1.69304e-06 (rank : 729)	NC score	0.792798 (rank : 472)
Query Neighborhood Hits	1580	Target Neighborhood Hits	657	Shared Neighborhood Hits	649
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TRIB2_MOUSE
θ value	1.69304e-06 (rank : 730)	NC score	0.792448 (rank : 474)
Query Neighborhood Hits	1580	Target Neighborhood Hits	653	Shared Neighborhood Hits	645
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

TYK2_MOUSE
θ value	1.69304e-06 (rank : 731)	NC score	0.703886 (rank : 585)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	799
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

CNTN4_HUMAN
θ value	2.21117e-06 (rank : 732)	NC score	0.183433 (rank : 951)
Query Neighborhood Hits	1580	Target Neighborhood Hits	449	Shared Neighborhood Hits	264
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

EPHB2_HUMAN
θ value	2.21117e-06 (rank : 733)	NC score	0.630969 (rank : 703)
Query Neighborhood Hits	1580	Target Neighborhood Hits	983	Shared Neighborhood Hits	833
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	2.21117e-06 (rank : 734)	NC score	0.631157 (rank : 702)
Query Neighborhood Hits	1580	Target Neighborhood Hits	982	Shared Neighborhood Hits	833
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

SRPK2_HUMAN
θ value	2.21117e-06 (rank : 735)	NC score	0.554824 (rank : 802)
Query Neighborhood Hits	1580	Target Neighborhood Hits	664	Shared Neighborhood Hits	599
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_MOUSE
θ value	2.21117e-06 (rank : 736)	NC score	0.559064 (rank : 799)
Query Neighborhood Hits	1580	Target Neighborhood Hits	765	Shared Neighborhood Hits	646
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

UTRO_HUMAN
θ value	2.21117e-06 (rank : 737)	NC score	0.167020 (rank : 995)
Query Neighborhood Hits	1580	Target Neighborhood Hits	960	Shared Neighborhood Hits	298
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

VGFR1_HUMAN
θ value	2.21117e-06 (rank : 738)	NC score	0.625780 (rank : 722)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1109	Shared Neighborhood Hits	973
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ARAF_HUMAN
θ value	2.88788e-06 (rank : 739)	NC score	0.746315 (rank : 558)
Query Neighborhood Hits	1580	Target Neighborhood Hits	924	Shared Neighborhood Hits	815
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARHGG_HUMAN
θ value	2.88788e-06 (rank : 740)	NC score	0.175179 (rank : 979)
Query Neighborhood Hits	1580	Target Neighborhood Hits	129	Shared Neighborhood Hits	88
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DSCL1_HUMAN
θ value	2.88788e-06 (rank : 741)	NC score	0.194085 (rank : 910)
Query Neighborhood Hits	1580	Target Neighborhood Hits	589	Shared Neighborhood Hits	306
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

HOOK3_HUMAN
θ value	2.88788e-06 (rank : 742)	NC score	0.142318 (rank : 1100)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1070	Shared Neighborhood Hits	325
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

MK06_HUMAN
θ value	2.88788e-06 (rank : 743)	NC score	0.785939 (rank : 494)
Query Neighborhood Hits	1580	Target Neighborhood Hits	815	Shared Neighborhood Hits	785
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
θ value	2.88788e-06 (rank : 744)	NC score	0.785707 (rank : 495)
Query Neighborhood Hits	1580	Target Neighborhood Hits	818	Shared Neighborhood Hits	787
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

MYPC1_HUMAN
θ value	2.88788e-06 (rank : 745)	NC score	0.185336 (rank : 941)
Query Neighborhood Hits	1580	Target Neighborhood Hits	303	Shared Neighborhood Hits	219
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

PTK7_HUMAN
θ value	2.88788e-06 (rank : 746)	NC score	0.654864 (rank : 659)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1103	Shared Neighborhood Hits	956
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

ARHGC_MOUSE
θ value	3.77169e-06 (rank : 747)	NC score	0.153172 (rank : 1028)
Query Neighborhood Hits	1580	Target Neighborhood Hits	344	Shared Neighborhood Hits	130
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ERN2_HUMAN
θ value	3.77169e-06 (rank : 748)	NC score	0.792603 (rank : 473)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	798
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

GAK_MOUSE
θ value	3.77169e-06 (rank : 749)	NC score	0.776504 (rank : 515)
Query Neighborhood Hits	1580	Target Neighborhood Hits	964	Shared Neighborhood Hits	802
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

IGF1R_MOUSE
θ value	3.77169e-06 (rank : 750)	NC score	0.599172 (rank : 757)
Query Neighborhood Hits	1580	Target Neighborhood Hits	973	Shared Neighborhood Hits	800
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LRIG1_MOUSE
θ value	3.77169e-06 (rank : 751)	NC score	0.143967 (rank : 1090)
Query Neighborhood Hits	1580	Target Neighborhood Hits	627	Shared Neighborhood Hits	254
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

MOS_MOUSE
θ value	3.77169e-06 (rank : 752)	NC score	0.746623 (rank : 557)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	803
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MYBPH_HUMAN
θ value	3.77169e-06 (rank : 753)	NC score	0.181396 (rank : 964)
Query Neighborhood Hits	1580	Target Neighborhood Hits	256	Shared Neighborhood Hits	212
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

STK23_HUMAN
θ value	3.77169e-06 (rank : 754)	NC score	0.549339 (rank : 806)
Query Neighborhood Hits	1580	Target Neighborhood Hits	556	Shared Neighborhood Hits	549
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	3.77169e-06 (rank : 755)	NC score	0.549701 (rank : 805)
Query Neighborhood Hits	1580	Target Neighborhood Hits	572	Shared Neighborhood Hits	554
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

TESK1_HUMAN
θ value	3.77169e-06 (rank : 756)	NC score	0.763061 (rank : 541)
Query Neighborhood Hits	1580	Target Neighborhood Hits	864	Shared Neighborhood Hits	794
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

KAZD1_MOUSE
θ value	4.92598e-06 (rank : 757)	NC score	0.159061 (rank : 1006)
Query Neighborhood Hits	1580	Target Neighborhood Hits	281	Shared Neighborhood Hits	188
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

RGNEF_MOUSE
θ value	4.92598e-06 (rank : 758)	NC score	0.191625 (rank : 919)
Query Neighborhood Hits	1580	Target Neighborhood Hits	641	Shared Neighborhood Hits	303
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ROBO3_MOUSE
θ value	4.92598e-06 (rank : 759)	NC score	0.195083 (rank : 908)
Query Neighborhood Hits	1580	Target Neighborhood Hits	524	Shared Neighborhood Hits	288
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

SRPK1_HUMAN
θ value	4.92598e-06 (rank : 760)	NC score	0.551192 (rank : 804)
Query Neighborhood Hits	1580	Target Neighborhood Hits	706	Shared Neighborhood Hits	592
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_MOUSE
θ value	4.92598e-06 (rank : 761)	NC score	0.552037 (rank : 803)
Query Neighborhood Hits	1580	Target Neighborhood Hits	639	Shared Neighborhood Hits	574
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

IGF1R_HUMAN
θ value	6.43352e-06 (rank : 762)	NC score	0.596412 (rank : 762)
Query Neighborhood Hits	1580	Target Neighborhood Hits	977	Shared Neighborhood Hits	802
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

LIMK1_MOUSE
θ value	6.43352e-06 (rank : 763)	NC score	0.734738 (rank : 569)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1008	Shared Neighborhood Hits	803
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

LRFN4_HUMAN
θ value	6.43352e-06 (rank : 764)	NC score	0.126107 (rank : 1245)
Query Neighborhood Hits	1580	Target Neighborhood Hits	462	Shared Neighborhood Hits	206
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRFN4_MOUSE
θ value	6.43352e-06 (rank : 765)	NC score	0.125645 (rank : 1251)
Query Neighborhood Hits	1580	Target Neighborhood Hits	442	Shared Neighborhood Hits	202
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LSAMP_HUMAN
θ value	6.43352e-06 (rank : 766)	NC score	0.183381 (rank : 953)
Query Neighborhood Hits	1580	Target Neighborhood Hits	347	Shared Neighborhood Hits	237
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

MYBPH_MOUSE
θ value	6.43352e-06 (rank : 767)	NC score	0.178622 (rank : 975)
Query Neighborhood Hits	1580	Target Neighborhood Hits	290	Shared Neighborhood Hits	213
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

MYPC2_HUMAN
θ value	6.43352e-06 (rank : 768)	NC score	0.183975 (rank : 948)
Query Neighborhood Hits	1580	Target Neighborhood Hits	316	Shared Neighborhood Hits	229
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

EPHB6_MOUSE
θ value	8.40245e-06 (rank : 769)	NC score	0.538497 (rank : 808)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	746
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ERBB2_HUMAN
θ value	8.40245e-06 (rank : 770)	NC score	0.626011 (rank : 719)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1073	Shared Neighborhood Hits	801
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB4_HUMAN
θ value	8.40245e-06 (rank : 771)	NC score	0.639557 (rank : 684)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	784
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

GOGA3_HUMAN
θ value	8.40245e-06 (rank : 772)	NC score	0.153505 (rank : 1027)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1317	Shared Neighborhood Hits	354
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

MAMC1_HUMAN
θ value	8.40245e-06 (rank : 773)	NC score	0.171060 (rank : 987)
Query Neighborhood Hits	1580	Target Neighborhood Hits	357	Shared Neighborhood Hits	234
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

ROBO1_HUMAN
θ value	8.40245e-06 (rank : 774)	NC score	0.198716 (rank : 897)
Query Neighborhood Hits	1580	Target Neighborhood Hits	529	Shared Neighborhood Hits	285
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO1_MOUSE
θ value	8.40245e-06 (rank : 775)	NC score	0.198518 (rank : 898)
Query Neighborhood Hits	1580	Target Neighborhood Hits	559	Shared Neighborhood Hits	286
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ROBO3_HUMAN
θ value	8.40245e-06 (rank : 776)	NC score	0.196800 (rank : 903)
Query Neighborhood Hits	1580	Target Neighborhood Hits	570	Shared Neighborhood Hits	294
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

TESK2_MOUSE
θ value	8.40245e-06 (rank : 777)	NC score	0.762687 (rank : 542)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	794
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

BCR_HUMAN
θ value	1.09739e-05 (rank : 778)	NC score	0.111287 (rank : 1364)
Query Neighborhood Hits	1580	Target Neighborhood Hits	204	Shared Neighborhood Hits	79
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

CENPE_HUMAN
θ value	1.09739e-05 (rank : 779)	NC score	0.134117 (rank : 1174)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2060	Shared Neighborhood Hits	427
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

FGFR3_HUMAN
θ value	1.09739e-05 (rank : 780)	NC score	0.668024 (rank : 643)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1042	Shared Neighborhood Hits	961
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

GAK_HUMAN
θ value	1.09739e-05 (rank : 781)	NC score	0.778609 (rank : 513)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1028	Shared Neighborhood Hits	807
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

GOGA2_HUMAN
θ value	1.09739e-05 (rank : 782)	NC score	0.141554 (rank : 1112)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	294
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

GOGA3_MOUSE
θ value	1.09739e-05 (rank : 783)	NC score	0.153838 (rank : 1026)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1437	Shared Neighborhood Hits	377
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

INSRR_HUMAN
θ value	1.09739e-05 (rank : 784)	NC score	0.595536 (rank : 763)
Query Neighborhood Hits	1580	Target Neighborhood Hits	950	Shared Neighborhood Hits	792
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

LIMK1_HUMAN
θ value	1.09739e-05 (rank : 785)	NC score	0.735227 (rank : 568)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1005	Shared Neighborhood Hits	803
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LRFN3_MOUSE
θ value	1.09739e-05 (rank : 786)	NC score	0.122756 (rank : 1268)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	204
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

MAMC1_MOUSE
θ value	1.09739e-05 (rank : 787)	NC score	0.170572 (rank : 988)
Query Neighborhood Hits	1580	Target Neighborhood Hits	357	Shared Neighborhood Hits	232
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MYH8_MOUSE
θ value	1.09739e-05 (rank : 788)	NC score	0.139504 (rank : 1132)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1600	Shared Neighborhood Hits	371
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYOM1_HUMAN
θ value	1.09739e-05 (rank : 789)	NC score	0.185105 (rank : 942)
Query Neighborhood Hits	1580	Target Neighborhood Hits	405	Shared Neighborhood Hits	250
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

SCYL2_HUMAN
θ value	1.09739e-05 (rank : 790)	NC score	0.625881 (rank : 721)
Query Neighborhood Hits	1580	Target Neighborhood Hits	632	Shared Neighborhood Hits	579
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

SYNE2_HUMAN
θ value	1.09739e-05 (rank : 791)	NC score	0.174221 (rank : 980)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1323	Shared Neighborhood Hits	359
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TRIB1_HUMAN
θ value	1.09739e-05 (rank : 792)	NC score	0.770808 (rank : 529)
Query Neighborhood Hits	1580	Target Neighborhood Hits	598	Shared Neighborhood Hits	585
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB3_MOUSE
θ value	1.09739e-05 (rank : 793)	NC score	0.753866 (rank : 547)
Query Neighborhood Hits	1580	Target Neighborhood Hits	578	Shared Neighborhood Hits	569
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

CNTN6_HUMAN
θ value	1.43324e-05 (rank : 794)	NC score	0.179552 (rank : 970)
Query Neighborhood Hits	1580	Target Neighborhood Hits	422	Shared Neighborhood Hits	265
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

CNTN6_MOUSE
θ value	1.43324e-05 (rank : 795)	NC score	0.179670 (rank : 969)
Query Neighborhood Hits	1580	Target Neighborhood Hits	429	Shared Neighborhood Hits	263
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

LRRK1_HUMAN
θ value	1.43324e-05 (rank : 796)	NC score	0.710993 (rank : 579)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1237	Shared Neighborhood Hits	822
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

LSAMP_MOUSE
θ value	1.43324e-05 (rank : 797)	NC score	0.182633 (rank : 956)
Query Neighborhood Hits	1580	Target Neighborhood Hits	344	Shared Neighborhood Hits	237
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

MYPN_HUMAN
θ value	1.43324e-05 (rank : 798)	NC score	0.203937 (rank : 888)
Query Neighborhood Hits	1580	Target Neighborhood Hits	418	Shared Neighborhood Hits	254
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

NCA11_HUMAN
θ value	1.43324e-05 (rank : 799)	NC score	0.188137 (rank : 928)
Query Neighborhood Hits	1580	Target Neighborhood Hits	443	Shared Neighborhood Hits	267
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NCA12_HUMAN
θ value	1.43324e-05 (rank : 800)	NC score	0.188670 (rank : 926)
Query Neighborhood Hits	1580	Target Neighborhood Hits	437	Shared Neighborhood Hits	266
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

RIPK3_MOUSE
θ value	1.43324e-05 (rank : 801)	NC score	0.749117 (rank : 556)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	788
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

STYK1_HUMAN
θ value	1.43324e-05 (rank : 802)	NC score	0.640643 (rank : 682)
Query Neighborhood Hits	1580	Target Neighborhood Hits	786	Shared Neighborhood Hits	754
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

ATL3_HUMAN
θ value	1.87187e-05 (rank : 803)	NC score	0.108322 (rank : 1383)
Query Neighborhood Hits	1580	Target Neighborhood Hits	414	Shared Neighborhood Hits	232
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

CF060_HUMAN
θ value	1.87187e-05 (rank : 804)	NC score	0.158849 (rank : 1008)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1270	Shared Neighborhood Hits	370
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CNTN4_MOUSE
θ value	1.87187e-05 (rank : 805)	NC score	0.183371 (rank : 954)
Query Neighborhood Hits	1580	Target Neighborhood Hits	445	Shared Neighborhood Hits	263
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

DDR2_HUMAN
θ value	1.87187e-05 (rank : 806)	NC score	0.616630 (rank : 737)
Query Neighborhood Hits	1580	Target Neighborhood Hits	818	Shared Neighborhood Hits	758
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	1.87187e-05 (rank : 807)	NC score	0.622582 (rank : 729)
Query Neighborhood Hits	1580	Target Neighborhood Hits	813	Shared Neighborhood Hits	759
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHA8_MOUSE
θ value	1.87187e-05 (rank : 808)	NC score	0.623827 (rank : 725)
Query Neighborhood Hits	1580	Target Neighborhood Hits	969	Shared Neighborhood Hits	843
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHB6_HUMAN
θ value	1.87187e-05 (rank : 809)	NC score	0.523876 (rank : 811)
Query Neighborhood Hits	1580	Target Neighborhood Hits	912	Shared Neighborhood Hits	725
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ERBB2_MOUSE
θ value	1.87187e-05 (rank : 810)	NC score	0.628848 (rank : 712)
Query Neighborhood Hits	1580	Target Neighborhood Hits	918	Shared Neighborhood Hits	791
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

FGFR2_HUMAN
θ value	1.87187e-05 (rank : 811)	NC score	0.676206 (rank : 630)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1062	Shared Neighborhood Hits	968
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	1.87187e-05 (rank : 812)	NC score	0.675457 (rank : 631)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1062	Shared Neighborhood Hits	964
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

GOGA2_MOUSE
θ value	1.87187e-05 (rank : 813)	NC score	0.149956 (rank : 1047)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	314
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

JAK1_MOUSE
θ value	1.87187e-05 (rank : 814)	NC score	0.689364 (rank : 601)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	802
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

LRFN3_HUMAN
θ value	1.87187e-05 (rank : 815)	NC score	0.119591 (rank : 1295)
Query Neighborhood Hits	1580	Target Neighborhood Hits	444	Shared Neighborhood Hits	199
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

MYPN_MOUSE
θ value	1.87187e-05 (rank : 816)	NC score	0.203318 (rank : 889)
Query Neighborhood Hits	1580	Target Neighborhood Hits	421	Shared Neighborhood Hits	245
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

SCYL2_MOUSE
θ value	1.87187e-05 (rank : 817)	NC score	0.605022 (rank : 753)
Query Neighborhood Hits	1580	Target Neighborhood Hits	603	Shared Neighborhood Hits	549
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

WEE1B_HUMAN
θ value	1.87187e-05 (rank : 818)	NC score	0.756533 (rank : 546)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	729
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

EPHA8_HUMAN
θ value	2.44474e-05 (rank : 819)	NC score	0.628152 (rank : 713)
Query Neighborhood Hits	1580	Target Neighborhood Hits	956	Shared Neighborhood Hits	843
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

FGFR3_MOUSE
θ value	2.44474e-05 (rank : 820)	NC score	0.665733 (rank : 646)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1059	Shared Neighborhood Hits	965
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

HMMR_MOUSE
θ value	2.44474e-05 (rank : 821)	NC score	0.149475 (rank : 1051)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1178	Shared Neighborhood Hits	345
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

LRFN2_MOUSE
θ value	2.44474e-05 (rank : 822)	NC score	0.125735 (rank : 1249)
Query Neighborhood Hits	1580	Target Neighborhood Hits	450	Shared Neighborhood Hits	203
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

MAGE1_HUMAN
θ value	2.44474e-05 (rank : 823)	NC score	0.019778 (rank : 2091)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1389	Shared Neighborhood Hits	180
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

MP2K6_HUMAN
θ value	2.44474e-05 (rank : 824)	NC score	0.798188 (rank : 441)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	802
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MYH1_HUMAN
θ value	2.44474e-05 (rank : 825)	NC score	0.140876 (rank : 1122)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1478	Shared Neighborhood Hits	365
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH6_HUMAN
θ value	2.44474e-05 (rank : 826)	NC score	0.138109 (rank : 1142)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1426	Shared Neighborhood Hits	351
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH8_HUMAN
θ value	2.44474e-05 (rank : 827)	NC score	0.140127 (rank : 1125)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1610	Shared Neighborhood Hits	378
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

RON_HUMAN
θ value	2.44474e-05 (rank : 828)	NC score	0.630657 (rank : 707)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	781
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

VGFR1_MOUSE
θ value	2.44474e-05 (rank : 829)	NC score	0.631617 (rank : 701)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1118	Shared Neighborhood Hits	980
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

CD2L2_HUMAN
θ value	3.19293e-05 (rank : 830)	NC score	0.787004 (rank : 488)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1439	Shared Neighborhood Hits	970
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

EPHA1_MOUSE
θ value	3.19293e-05 (rank : 831)	NC score	0.615415 (rank : 743)
Query Neighborhood Hits	1580	Target Neighborhood Hits	958	Shared Neighborhood Hits	820
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

KAZD1_HUMAN
θ value	3.19293e-05 (rank : 832)	NC score	0.142062 (rank : 1104)
Query Neighborhood Hits	1580	Target Neighborhood Hits	248	Shared Neighborhood Hits	158
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

ROR1_HUMAN
θ value	3.19293e-05 (rank : 833)	NC score	0.654857 (rank : 660)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1018	Shared Neighborhood Hits	937
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	3.19293e-05 (rank : 834)	NC score	0.656096 (rank : 657)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1025	Shared Neighborhood Hits	940
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

CP250_HUMAN
θ value	4.1701e-05 (rank : 835)	NC score	0.154060 (rank : 1024)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1805	Shared Neighborhood Hits	396
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

EPHA4_HUMAN
θ value	4.1701e-05 (rank : 836)	NC score	0.629628 (rank : 709)
Query Neighborhood Hits	1580	Target Neighborhood Hits	975	Shared Neighborhood Hits	842
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	4.1701e-05 (rank : 837)	NC score	0.629964 (rank : 708)
Query Neighborhood Hits	1580	Target Neighborhood Hits	982	Shared Neighborhood Hits	845
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

FLT3_MOUSE
θ value	4.1701e-05 (rank : 838)	NC score	0.572345 (rank : 791)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	819
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

LRC21_MOUSE
θ value	4.1701e-05 (rank : 839)	NC score	0.111207 (rank : 1365)
Query Neighborhood Hits	1580	Target Neighborhood Hits	462	Shared Neighborhood Hits	211
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

LRFN2_HUMAN
θ value	4.1701e-05 (rank : 840)	NC score	0.125263 (rank : 1254)
Query Neighborhood Hits	1580	Target Neighborhood Hits	450	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

MYOTI_MOUSE
θ value	4.1701e-05 (rank : 841)	NC score	0.199009 (rank : 896)
Query Neighborhood Hits	1580	Target Neighborhood Hits	297	Shared Neighborhood Hits	215
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

CD2L1_HUMAN
θ value	5.44631e-05 (rank : 842)	NC score	0.786264 (rank : 493)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1467	Shared Neighborhood Hits	976
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

CD2L1_MOUSE
θ value	5.44631e-05 (rank : 843)	NC score	0.786395 (rank : 492)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1463	Shared Neighborhood Hits	972
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

DSCAM_HUMAN
θ value	5.44631e-05 (rank : 844)	NC score	0.193816 (rank : 911)
Query Neighborhood Hits	1580	Target Neighborhood Hits	524	Shared Neighborhood Hits	283
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

E2AK2_HUMAN
θ value	5.44631e-05 (rank : 845)	NC score	0.813636 (rank : 363)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	806
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

INSRR_MOUSE
θ value	5.44631e-05 (rank : 846)	NC score	0.598385 (rank : 759)
Query Neighborhood Hits	1580	Target Neighborhood Hits	961	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

LRIG3_HUMAN
θ value	5.44631e-05 (rank : 847)	NC score	0.137620 (rank : 1147)
Query Neighborhood Hits	1580	Target Neighborhood Hits	601	Shared Neighborhood Hits	253
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

MYOM1_MOUSE
θ value	5.44631e-05 (rank : 848)	NC score	0.188629 (rank : 927)
Query Neighborhood Hits	1580	Target Neighborhood Hits	415	Shared Neighborhood Hits	261
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

TESK2_HUMAN
θ value	5.44631e-05 (rank : 849)	NC score	0.763178 (rank : 540)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	797
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TRIB1_MOUSE
θ value	5.44631e-05 (rank : 850)	NC score	0.769005 (rank : 530)
Query Neighborhood Hits	1580	Target Neighborhood Hits	593	Shared Neighborhood Hits	586
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

DDR1_MOUSE
θ value	7.1131e-05 (rank : 851)	NC score	0.592358 (rank : 770)
Query Neighborhood Hits	1580	Target Neighborhood Hits	818	Shared Neighborhood Hits	752
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

L1CAM_MOUSE
θ value	7.1131e-05 (rank : 852)	NC score	0.185565 (rank : 939)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	275
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

LRIG3_MOUSE
θ value	7.1131e-05 (rank : 853)	NC score	0.138415 (rank : 1139)
Query Neighborhood Hits	1580	Target Neighborhood Hits	611	Shared Neighborhood Hits	255
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

MP2K3_MOUSE
θ value	7.1131e-05 (rank : 854)	NC score	0.803270 (rank : 416)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	799
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MYPC2_MOUSE
θ value	7.1131e-05 (rank : 855)	NC score	0.179487 (rank : 972)
Query Neighborhood Hits	1580	Target Neighborhood Hits	297	Shared Neighborhood Hits	218
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

NCA11_MOUSE
θ value	7.1131e-05 (rank : 856)	NC score	0.186621 (rank : 933)
Query Neighborhood Hits	1580	Target Neighborhood Hits	661	Shared Neighborhood Hits	316
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

NCA12_MOUSE
θ value	7.1131e-05 (rank : 857)	NC score	0.185354 (rank : 940)
Query Neighborhood Hits	1580	Target Neighborhood Hits	399	Shared Neighborhood Hits	255
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

NFASC_HUMAN
θ value	7.1131e-05 (rank : 858)	NC score	0.187847 (rank : 929)
Query Neighborhood Hits	1580	Target Neighborhood Hits	497	Shared Neighborhood Hits	286
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NTRK3_HUMAN
θ value	7.1131e-05 (rank : 859)	NC score	0.644811 (rank : 675)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1115	Shared Neighborhood Hits	929
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

RIPK3_HUMAN
θ value	7.1131e-05 (rank : 860)	NC score	0.742178 (rank : 561)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	789
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

VGFR2_MOUSE
θ value	7.1131e-05 (rank : 861)	NC score	0.622757 (rank : 728)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1089	Shared Neighborhood Hits	960
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

CHL1_MOUSE
θ value	9.29e-05 (rank : 862)	NC score	0.178349 (rank : 977)
Query Neighborhood Hits	1580	Target Neighborhood Hits	402	Shared Neighborhood Hits	260
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CNTN2_HUMAN
θ value	9.29e-05 (rank : 863)	NC score	0.182113 (rank : 959)
Query Neighborhood Hits	1580	Target Neighborhood Hits	440	Shared Neighborhood Hits	276
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

EPHA6_MOUSE
θ value	9.29e-05 (rank : 864)	NC score	0.584435 (rank : 781)
Query Neighborhood Hits	1580	Target Neighborhood Hits	946	Shared Neighborhood Hits	822
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

MP2K3_HUMAN
θ value	9.29e-05 (rank : 865)	NC score	0.801064 (rank : 425)
Query Neighborhood Hits	1580	Target Neighborhood Hits	825	Shared Neighborhood Hits	799
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MYH11_MOUSE
θ value	9.29e-05 (rank : 866)	NC score	0.140323 (rank : 1124)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1777	Shared Neighborhood Hits	394
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

NFASC_MOUSE
θ value	9.29e-05 (rank : 867)	NC score	0.187590 (rank : 930)
Query Neighborhood Hits	1580	Target Neighborhood Hits	475	Shared Neighborhood Hits	285
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

PGBM_HUMAN
θ value	9.29e-05 (rank : 868)	NC score	0.130681 (rank : 1202)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1113	Shared Neighborhood Hits	285
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

CNTN3_HUMAN
θ value	0.000121331 (rank : 869)	NC score	0.182200 (rank : 958)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	272
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

DDR1_HUMAN
θ value	0.000121331 (rank : 870)	NC score	0.590153 (rank : 772)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	757
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

EGFR_MOUSE
θ value	0.000121331 (rank : 871)	NC score	0.638497 (rank : 686)
Query Neighborhood Hits	1580	Target Neighborhood Hits	927	Shared Neighborhood Hits	792
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA6_HUMAN
θ value	0.000121331 (rank : 872)	NC score	0.580836 (rank : 783)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	825
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

MYPC3_HUMAN
θ value	0.000121331 (rank : 873)	NC score	0.182912 (rank : 955)
Query Neighborhood Hits	1580	Target Neighborhood Hits	318	Shared Neighborhood Hits	230
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

RET_HUMAN
θ value	0.000121331 (rank : 874)	NC score	0.647567 (rank : 667)
Query Neighborhood Hits	1580	Target Neighborhood Hits	873	Shared Neighborhood Hits	791
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

STYK1_MOUSE
θ value	0.000121331 (rank : 875)	NC score	0.623030 (rank : 727)
Query Neighborhood Hits	1580	Target Neighborhood Hits	779	Shared Neighborhood Hits	749
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

DESP_HUMAN
θ value	0.000158464 (rank : 876)	NC score	0.150440 (rank : 1041)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1470	Shared Neighborhood Hits	383
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

FGFR4_HUMAN
θ value	0.000158464 (rank : 877)	NC score	0.658956 (rank : 654)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1037	Shared Neighborhood Hits	965
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FLT3_HUMAN
θ value	0.000158464 (rank : 878)	NC score	0.572664 (rank : 790)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	808
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

GOGA5_MOUSE
θ value	0.000158464 (rank : 879)	NC score	0.133659 (rank : 1180)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1434	Shared Neighborhood Hits	358
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

OPCM_HUMAN
θ value	0.000158464 (rank : 880)	NC score	0.180051 (rank : 967)
Query Neighborhood Hits	1580	Target Neighborhood Hits	332	Shared Neighborhood Hits	234
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

RBCC1_MOUSE
θ value	0.000158464 (rank : 881)	NC score	0.141290 (rank : 1118)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1048	Shared Neighborhood Hits	335
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

RET_MOUSE
θ value	0.000158464 (rank : 882)	NC score	0.645775 (rank : 671)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	790
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

TNK1_MOUSE
θ value	0.000158464 (rank : 883)	NC score	0.661756 (rank : 651)
Query Neighborhood Hits	1580	Target Neighborhood Hits	806	Shared Neighborhood Hits	763
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

CDON_HUMAN
θ value	0.00020696 (rank : 884)	NC score	0.185707 (rank : 938)
Query Neighborhood Hits	1580	Target Neighborhood Hits	412	Shared Neighborhood Hits	243
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

CE152_HUMAN
θ value	0.00020696 (rank : 885)	NC score	0.150271 (rank : 1042)
Query Neighborhood Hits	1580	Target Neighborhood Hits	976	Shared Neighborhood Hits	307
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

CNTN1_MOUSE
θ value	0.00020696 (rank : 886)	NC score	0.179909 (rank : 968)
Query Neighborhood Hits	1580	Target Neighborhood Hits	422	Shared Neighborhood Hits	267
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN2_MOUSE
θ value	0.00020696 (rank : 887)	NC score	0.181752 (rank : 960)
Query Neighborhood Hits	1580	Target Neighborhood Hits	450	Shared Neighborhood Hits	275
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

EPHA2_HUMAN
θ value	0.00020696 (rank : 888)	NC score	0.632641 (rank : 698)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1021	Shared Neighborhood Hits	846
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA3_HUMAN
θ value	0.00020696 (rank : 889)	NC score	0.640737 (rank : 681)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1005	Shared Neighborhood Hits	863
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

FGFR1_HUMAN
θ value	0.00020696 (rank : 890)	NC score	0.676591 (rank : 629)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1069	Shared Neighborhood Hits	975
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	0.00020696 (rank : 891)	NC score	0.676633 (rank : 628)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1068	Shared Neighborhood Hits	974
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

INSR_HUMAN
θ value	0.00020696 (rank : 892)	NC score	0.616107 (rank : 740)
Query Neighborhood Hits	1580	Target Neighborhood Hits	963	Shared Neighborhood Hits	814
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

LRC21_HUMAN
θ value	0.00020696 (rank : 893)	NC score	0.110352 (rank : 1375)
Query Neighborhood Hits	1580	Target Neighborhood Hits	456	Shared Neighborhood Hits	207
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

MUSK_MOUSE
θ value	0.00020696 (rank : 894)	NC score	0.632034 (rank : 700)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1057	Shared Neighborhood Hits	950
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

PTPRS_HUMAN
θ value	0.00020696 (rank : 895)	NC score	0.133380 (rank : 1183)
Query Neighborhood Hits	1580	Target Neighborhood Hits	472	Shared Neighborhood Hits	257
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

RPKL1_MOUSE
θ value	0.00020696 (rank : 896)	NC score	0.708730 (rank : 580)
Query Neighborhood Hits	1580	Target Neighborhood Hits	704	Shared Neighborhood Hits	655
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

CE290_HUMAN
θ value	0.000270298 (rank : 897)	NC score	0.150006 (rank : 1045)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1553	Shared Neighborhood Hits	370
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

CNTN1_HUMAN
θ value	0.000270298 (rank : 898)	NC score	0.179349 (rank : 974)
Query Neighborhood Hits	1580	Target Neighborhood Hits	431	Shared Neighborhood Hits	266
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

EEA1_HUMAN
θ value	0.000270298 (rank : 899)	NC score	0.161184 (rank : 1002)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1796	Shared Neighborhood Hits	404
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

EGFR_HUMAN
θ value	0.000270298 (rank : 900)	NC score	0.637740 (rank : 687)
Query Neighborhood Hits	1580	Target Neighborhood Hits	939	Shared Neighborhood Hits	789
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EPHA5_MOUSE
θ value	0.000270298 (rank : 901)	NC score	0.650692 (rank : 665)
Query Neighborhood Hits	1580	Target Neighborhood Hits	950	Shared Neighborhood Hits	837
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

INSR_MOUSE
θ value	0.000270298 (rank : 902)	NC score	0.614385 (rank : 746)
Query Neighborhood Hits	1580	Target Neighborhood Hits	968	Shared Neighborhood Hits	807
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

MP2K6_MOUSE
θ value	0.000270298 (rank : 903)	NC score	0.799286 (rank : 434)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	803
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MYH1_MOUSE
θ value	0.000270298 (rank : 904)	NC score	0.139968 (rank : 1127)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1461	Shared Neighborhood Hits	361
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH4_MOUSE
θ value	0.000270298 (rank : 905)	NC score	0.137490 (rank : 1149)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1476	Shared Neighborhood Hits	361
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

NTRK1_HUMAN
θ value	0.000270298 (rank : 906)	NC score	0.625926 (rank : 720)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1023	Shared Neighborhood Hits	868
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

SPAG5_MOUSE
θ value	0.000270298 (rank : 907)	NC score	0.130501 (rank : 1205)
Query Neighborhood Hits	1580	Target Neighborhood Hits	612	Shared Neighborhood Hits	263
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

VGFR2_HUMAN
θ value	0.000270298 (rank : 908)	NC score	0.618556 (rank : 736)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1103	Shared Neighborhood Hits	957
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

CCD46_HUMAN
θ value	0.00035302 (rank : 909)	NC score	0.151771 (rank : 1037)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1430	Shared Neighborhood Hits	366
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CNTN5_HUMAN
θ value	0.00035302 (rank : 910)	NC score	0.184079 (rank : 947)
Query Neighborhood Hits	1580	Target Neighborhood Hits	446	Shared Neighborhood Hits	275
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

CP250_MOUSE
θ value	0.00035302 (rank : 911)	NC score	0.156875 (rank : 1015)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1583	Shared Neighborhood Hits	384
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

MYPC3_MOUSE
θ value	0.00035302 (rank : 912)	NC score	0.184395 (rank : 946)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	229
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

NPTN_MOUSE
θ value	0.00035302 (rank : 913)	NC score	0.167442 (rank : 993)
Query Neighborhood Hits	1580	Target Neighborhood Hits	216	Shared Neighborhood Hits	190
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

PGFRA_HUMAN
θ value	0.00035302 (rank : 914)	NC score	0.604050 (rank : 754)
Query Neighborhood Hits	1580	Target Neighborhood Hits	980	Shared Neighborhood Hits	910
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PLEC1_HUMAN
θ value	0.00035302 (rank : 915)	NC score	0.164175 (rank : 998)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1326	Shared Neighborhood Hits	351
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

PTPRD_HUMAN
θ value	0.00035302 (rank : 916)	NC score	0.133814 (rank : 1178)
Query Neighborhood Hits	1580	Target Neighborhood Hits	485	Shared Neighborhood Hits	254
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

PTPRD_MOUSE
θ value	0.00035302 (rank : 917)	NC score	0.135863 (rank : 1162)
Query Neighborhood Hits	1580	Target Neighborhood Hits	491	Shared Neighborhood Hits	263
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

SOS2_HUMAN
θ value	0.00035302 (rank : 918)	NC score	0.084365 (rank : 1573)
Query Neighborhood Hits	1580	Target Neighborhood Hits	193	Shared Neighborhood Hits	65
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

UHMK1_HUMAN
θ value	0.00035302 (rank : 919)	NC score	0.773312 (rank : 521)
Query Neighborhood Hits	1580	Target Neighborhood Hits	808	Shared Neighborhood Hits	753
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

AVR2A_HUMAN
θ value	0.000461057 (rank : 920)	NC score	0.626543 (rank : 717)
Query Neighborhood Hits	1580	Target Neighborhood Hits	767	Shared Neighborhood Hits	744
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

AVR2A_MOUSE
θ value	0.000461057 (rank : 921)	NC score	0.626557 (rank : 716)
Query Neighborhood Hits	1580	Target Neighborhood Hits	767	Shared Neighborhood Hits	744
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

CNTN3_MOUSE
θ value	0.000461057 (rank : 922)	NC score	0.179356 (rank : 973)
Query Neighborhood Hits	1580	Target Neighborhood Hits	447	Shared Neighborhood Hits	265
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

EPHAA_HUMAN
θ value	0.000461057 (rank : 923)	NC score	0.531084 (rank : 809)
Query Neighborhood Hits	1580	Target Neighborhood Hits	960	Shared Neighborhood Hits	769
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

NFH_MOUSE
θ value	0.000461057 (rank : 924)	NC score	0.050268 (rank : 2017)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2247	Shared Neighborhood Hits	410
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NTRI_HUMAN
θ value	0.000461057 (rank : 925)	NC score	0.173585 (rank : 984)
Query Neighborhood Hits	1580	Target Neighborhood Hits	344	Shared Neighborhood Hits	238
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

NTRI_MOUSE
θ value	0.000461057 (rank : 926)	NC score	0.174098 (rank : 982)
Query Neighborhood Hits	1580	Target Neighborhood Hits	342	Shared Neighborhood Hits	239
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

PGFRA_MOUSE
θ value	0.000461057 (rank : 927)	NC score	0.601389 (rank : 756)
Query Neighborhood Hits	1580	Target Neighborhood Hits	975	Shared Neighborhood Hits	900
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

SOS1_HUMAN
θ value	0.000461057 (rank : 928)	NC score	0.087381 (rank : 1539)
Query Neighborhood Hits	1580	Target Neighborhood Hits	274	Shared Neighborhood Hits	78
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

UHMK1_MOUSE
θ value	0.000461057 (rank : 929)	NC score	0.771867 (rank : 524)
Query Neighborhood Hits	1580	Target Neighborhood Hits	809	Shared Neighborhood Hits	753
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

ARHG5_HUMAN
θ value	0.000602161 (rank : 930)	NC score	0.170379 (rank : 989)
Query Neighborhood Hits	1580	Target Neighborhood Hits	172	Shared Neighborhood Hits	96
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

IGS4B_HUMAN
θ value	0.000602161 (rank : 931)	NC score	0.128285 (rank : 1222)
Query Neighborhood Hits	1580	Target Neighborhood Hits	305	Shared Neighborhood Hits	201
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

IGS4B_MOUSE
θ value	0.000602161 (rank : 932)	NC score	0.133666 (rank : 1179)
Query Neighborhood Hits	1580	Target Neighborhood Hits	328	Shared Neighborhood Hits	204
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

IRAK3_MOUSE
θ value	0.000602161 (rank : 933)	NC score	0.588014 (rank : 778)
Query Neighborhood Hits	1580	Target Neighborhood Hits	628	Shared Neighborhood Hits	591
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

MYH2_HUMAN
θ value	0.000602161 (rank : 934)	NC score	0.139526 (rank : 1130)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1491	Shared Neighborhood Hits	368
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

NGEF_MOUSE
θ value	0.000602161 (rank : 935)	NC score	0.165722 (rank : 996)
Query Neighborhood Hits	1580	Target Neighborhood Hits	228	Shared Neighborhood Hits	113
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PTPRF_HUMAN
θ value	0.000602161 (rank : 936)	NC score	0.135127 (rank : 1165)
Query Neighborhood Hits	1580	Target Neighborhood Hits	489	Shared Neighborhood Hits	265
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

RAD50_HUMAN
θ value	0.000602161 (rank : 937)	NC score	0.149705 (rank : 1049)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1317	Shared Neighborhood Hits	354
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

SDK2_HUMAN
θ value	0.000602161 (rank : 938)	NC score	0.183840 (rank : 949)
Query Neighborhood Hits	1580	Target Neighborhood Hits	495	Shared Neighborhood Hits	283
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CCD41_HUMAN
θ value	0.000786445 (rank : 939)	NC score	0.141983 (rank : 1105)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1139	Shared Neighborhood Hits	335
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

CDON_MOUSE
θ value	0.000786445 (rank : 940)	NC score	0.186396 (rank : 935)
Query Neighborhood Hits	1580	Target Neighborhood Hits	410	Shared Neighborhood Hits	250
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

EPHA2_MOUSE
θ value	0.000786445 (rank : 941)	NC score	0.630926 (rank : 704)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1020	Shared Neighborhood Hits	840
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA5_HUMAN
θ value	0.000786445 (rank : 942)	NC score	0.635855 (rank : 690)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	850
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

L1CAM_HUMAN
θ value	0.000786445 (rank : 943)	NC score	0.186853 (rank : 932)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	275
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

MYOTI_HUMAN
θ value	0.000786445 (rank : 944)	NC score	0.199775 (rank : 893)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	223
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

NCAM2_MOUSE
θ value	0.000786445 (rank : 945)	NC score	0.191095 (rank : 922)
Query Neighborhood Hits	1580	Target Neighborhood Hits	472	Shared Neighborhood Hits	274
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NTRK2_HUMAN
θ value	0.000786445 (rank : 946)	NC score	0.673854 (rank : 633)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1081	Shared Neighborhood Hits	945
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	0.000786445 (rank : 947)	NC score	0.673357 (rank : 635)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1088	Shared Neighborhood Hits	945
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

RON_MOUSE
θ value	0.000786445 (rank : 948)	NC score	0.619902 (rank : 733)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	776
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

SDK2_MOUSE
θ value	0.000786445 (rank : 949)	NC score	0.183627 (rank : 950)
Query Neighborhood Hits	1580	Target Neighborhood Hits	480	Shared Neighborhood Hits	281
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

AATK_MOUSE
θ value	0.00102713 (rank : 950)	NC score	0.606282 (rank : 751)
Query Neighborhood Hits	1580	Target Neighborhood Hits	942	Shared Neighborhood Hits	762
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABR_HUMAN
θ value	0.00102713 (rank : 951)	NC score	0.111831 (rank : 1359)
Query Neighborhood Hits	1580	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ACTN3_MOUSE
θ value	0.00102713 (rank : 952)	NC score	0.119198 (rank : 1299)
Query Neighborhood Hits	1580	Target Neighborhood Hits	265	Shared Neighborhood Hits	133
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

E2AK3_MOUSE
θ value	0.00102713 (rank : 953)	NC score	0.790030 (rank : 478)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	808
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

GOGB1_HUMAN
θ value	0.00102713 (rank : 954)	NC score	0.156047 (rank : 1017)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2297	Shared Neighborhood Hits	457
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

IRAK1_HUMAN
θ value	0.00102713 (rank : 955)	NC score	0.672948 (rank : 636)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	743
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

IRAK1_MOUSE
θ value	0.00102713 (rank : 956)	NC score	0.669271 (rank : 639)
Query Neighborhood Hits	1580	Target Neighborhood Hits	784	Shared Neighborhood Hits	726
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

LRRC4_HUMAN
θ value	0.00102713 (rank : 957)	NC score	0.082583 (rank : 1597)
Query Neighborhood Hits	1580	Target Neighborhood Hits	444	Shared Neighborhood Hits	180
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

MUSK_HUMAN
θ value	0.00102713 (rank : 958)	NC score	0.634655 (rank : 693)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1074	Shared Neighborhood Hits	954
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

NUMA1_HUMAN
θ value	0.00102713 (rank : 959)	NC score	0.153958 (rank : 1025)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1523	Shared Neighborhood Hits	366
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

TRIB3_HUMAN
θ value	0.00102713 (rank : 960)	NC score	0.733363 (rank : 571)
Query Neighborhood Hits	1580	Target Neighborhood Hits	519	Shared Neighborhood Hits	514
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

VGFR3_HUMAN
θ value	0.00102713 (rank : 961)	NC score	0.612749 (rank : 748)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1037	Shared Neighborhood Hits	938
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

EPHA3_MOUSE
θ value	0.00134147 (rank : 962)	NC score	0.633377 (rank : 696)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	866
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

FGFR4_MOUSE
θ value	0.00134147 (rank : 963)	NC score	0.637719 (rank : 688)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1026	Shared Neighborhood Hits	952
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

KIF5C_HUMAN
θ value	0.00134147 (rank : 964)	NC score	0.089855 (rank : 1523)
Query Neighborhood Hits	1580	Target Neighborhood Hits	974	Shared Neighborhood Hits	317
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

LAMA2_MOUSE
θ value	0.00134147 (rank : 965)	NC score	0.073742 (rank : 1675)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1198	Shared Neighborhood Hits	297
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

NEGR1_HUMAN
θ value	0.00134147 (rank : 966)	NC score	0.174213 (rank : 981)
Query Neighborhood Hits	1580	Target Neighborhood Hits	346	Shared Neighborhood Hits	237
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

PGBM_MOUSE
θ value	0.00134147 (rank : 967)	NC score	0.126920 (rank : 1239)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1073	Shared Neighborhood Hits	283
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

RIPK2_HUMAN
θ value	0.00134147 (rank : 968)	NC score	0.692032 (rank : 595)
Query Neighborhood Hits	1580	Target Neighborhood Hits	774	Shared Neighborhood Hits	738
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

TNK1_HUMAN
θ value	0.00134147 (rank : 969)	NC score	0.651369 (rank : 664)
Query Neighborhood Hits	1580	Target Neighborhood Hits	815	Shared Neighborhood Hits	761
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

VGFR3_MOUSE
θ value	0.00134147 (rank : 970)	NC score	0.616276 (rank : 739)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1056	Shared Neighborhood Hits	945
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

CNTN5_MOUSE
θ value	0.00175202 (rank : 971)	NC score	0.180678 (rank : 966)
Query Neighborhood Hits	1580	Target Neighborhood Hits	434	Shared Neighborhood Hits	272
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

GOGA5_HUMAN
θ value	0.00175202 (rank : 972)	NC score	0.134763 (rank : 1169)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1168	Shared Neighborhood Hits	336
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

KSR2_HUMAN
θ value	0.00175202 (rank : 973)	NC score	0.729405 (rank : 572)
Query Neighborhood Hits	1580	Target Neighborhood Hits	920	Shared Neighborhood Hits	799
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

RB6I2_MOUSE
θ value	0.00175202 (rank : 974)	NC score	0.144150 (rank : 1088)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1433	Shared Neighborhood Hits	359
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

SM1L2_MOUSE
θ value	0.00175202 (rank : 975)	NC score	0.124847 (rank : 1257)
Query Neighborhood Hits	1580	Target Neighborhood Hits	918	Shared Neighborhood Hits	313
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

ANKK1_HUMAN
θ value	0.00228821 (rank : 976)	NC score	0.573759 (rank : 789)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1075	Shared Neighborhood Hits	772
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANKK1_MOUSE
θ value	0.00228821 (rank : 977)	NC score	0.583941 (rank : 782)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1072	Shared Neighborhood Hits	778
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ARHGG_MOUSE
θ value	0.00228821 (rank : 978)	NC score	0.167202 (rank : 994)
Query Neighborhood Hits	1580	Target Neighborhood Hits	152	Shared Neighborhood Hits	84
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

BUB1_MOUSE
θ value	0.00228821 (rank : 979)	NC score	0.588464 (rank : 777)
Query Neighborhood Hits	1580	Target Neighborhood Hits	583	Shared Neighborhood Hits	542
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

CCD46_MOUSE
θ value	0.00228821 (rank : 980)	NC score	0.146799 (rank : 1069)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1405	Shared Neighborhood Hits	356
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

DOT1L_HUMAN
θ value	0.00228821 (rank : 981)	NC score	0.060743 (rank : 1834)
Query Neighborhood Hits	1580	Target Neighborhood Hits	660	Shared Neighborhood Hits	176
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

E2AK3_HUMAN
θ value	0.00228821 (rank : 982)	NC score	0.793276 (rank : 469)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	803
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

IBP7_HUMAN
θ value	0.00228821 (rank : 983)	NC score	0.137066 (rank : 1151)
Query Neighborhood Hits	1580	Target Neighborhood Hits	220	Shared Neighborhood Hits	159
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

LBC_HUMAN
θ value	0.00228821 (rank : 984)	NC score	0.147005 (rank : 1067)
Query Neighborhood Hits	1580	Target Neighborhood Hits	90	Shared Neighborhood Hits	70
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

NCAM2_HUMAN
θ value	0.00228821 (rank : 985)	NC score	0.190668 (rank : 923)
Query Neighborhood Hits	1580	Target Neighborhood Hits	441	Shared Neighborhood Hits	267
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

AATK_HUMAN
θ value	0.00298849 (rank : 986)	NC score	0.616572 (rank : 738)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1243	Shared Neighborhood Hits	788
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

ARHGB_HUMAN
θ value	0.00298849 (rank : 987)	NC score	0.156885 (rank : 1014)
Query Neighborhood Hits	1580	Target Neighborhood Hits	375	Shared Neighborhood Hits	126
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

CJ118_MOUSE
θ value	0.00298849 (rank : 988)	NC score	0.145496 (rank : 1077)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1132	Shared Neighborhood Hits	331
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

FSTL4_HUMAN
θ value	0.00298849 (rank : 989)	NC score	0.159828 (rank : 1004)
Query Neighborhood Hits	1580	Target Neighborhood Hits	344	Shared Neighborhood Hits	226
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

MYH14_HUMAN
θ value	0.00298849 (rank : 990)	NC score	0.130022 (rank : 1210)
Query Neighborhood Hits	1580	Target Neighborhood Hits	995	Shared Neighborhood Hits	310
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

NPHP1_MOUSE
θ value	0.00298849 (rank : 991)	NC score	0.110429 (rank : 1374)
Query Neighborhood Hits	1580	Target Neighborhood Hits	267	Shared Neighborhood Hits	121
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NRCAM_HUMAN
θ value	0.00298849 (rank : 992)	NC score	0.181566 (rank : 962)
Query Neighborhood Hits	1580	Target Neighborhood Hits	439	Shared Neighborhood Hits	268
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

ROS_HUMAN
θ value	0.00298849 (rank : 993)	NC score	0.626652 (rank : 714)
Query Neighborhood Hits	1580	Target Neighborhood Hits	907	Shared Neighborhood Hits	805
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

T22D4_HUMAN
θ value	0.00298849 (rank : 994)	NC score	0.027847 (rank : 2070)
Query Neighborhood Hits	1580	Target Neighborhood Hits	403	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

AVR2B_HUMAN
θ value	0.00390308 (rank : 995)	NC score	0.614836 (rank : 745)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	725
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_MOUSE
θ value	0.00390308 (rank : 996)	NC score	0.614988 (rank : 744)
Query Neighborhood Hits	1580	Target Neighborhood Hits	749	Shared Neighborhood Hits	725
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

CYTSA_MOUSE
θ value	0.00390308 (rank : 997)	NC score	0.146064 (rank : 1072)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1104	Shared Neighborhood Hits	346
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

GOGA4_MOUSE
θ value	0.00390308 (rank : 998)	NC score	0.152800 (rank : 1031)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1939	Shared Neighborhood Hits	406
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

GUC2E_MOUSE
θ value	0.00390308 (rank : 999)	NC score	0.426256 (rank : 828)
Query Neighborhood Hits	1580	Target Neighborhood Hits	692	Shared Neighborhood Hits	628
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

IASPP_MOUSE
θ value	0.00390308 (rank : 1000)	NC score	0.054174 (rank : 1947)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1024	Shared Neighborhood Hits	173
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NPTN_HUMAN
θ value	0.00390308 (rank : 1001)	NC score	0.162642 (rank : 999)
Query Neighborhood Hits	1580	Target Neighborhood Hits	212	Shared Neighborhood Hits	188
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

TRIPB_HUMAN
θ value	0.00390308 (rank : 1002)	NC score	0.156608 (rank : 1016)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1587	Shared Neighborhood Hits	394
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

INVO_HUMAN
θ value	0.00509761 (rank : 1003)	NC score	0.153002 (rank : 1029)
Query Neighborhood Hits	1580	Target Neighborhood Hits	636	Shared Neighborhood Hits	275
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

MERTK_MOUSE
θ value	0.00509761 (rank : 1004)	NC score	0.612609 (rank : 749)
Query Neighborhood Hits	1580	Target Neighborhood Hits	974	Shared Neighborhood Hits	854
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MFA3L_HUMAN
θ value	0.00509761 (rank : 1005)	NC score	0.158696 (rank : 1010)
Query Neighborhood Hits	1580	Target Neighborhood Hits	230	Shared Neighborhood Hits	198
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

MYOM2_HUMAN
θ value	0.00509761 (rank : 1006)	NC score	0.182261 (rank : 957)
Query Neighborhood Hits	1580	Target Neighborhood Hits	341	Shared Neighborhood Hits	232
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

RAD50_MOUSE
θ value	0.00509761 (rank : 1007)	NC score	0.149984 (rank : 1046)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1366	Shared Neighborhood Hits	358
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

SOS1_MOUSE
θ value	0.00509761 (rank : 1008)	NC score	0.085294 (rank : 1558)
Query Neighborhood Hits	1580	Target Neighborhood Hits	281	Shared Neighborhood Hits	87
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

TOPK_MOUSE
θ value	0.00509761 (rank : 1009)	NC score	0.568758 (rank : 794)
Query Neighborhood Hits	1580	Target Neighborhood Hits	618	Shared Neighborhood Hits	587
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

VCAM1_HUMAN
θ value	0.00509761 (rank : 1010)	NC score	0.158412 (rank : 1011)
Query Neighborhood Hits	1580	Target Neighborhood Hits	352	Shared Neighborhood Hits	218
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

WEE1B_MOUSE
θ value	0.00509761 (rank : 1011)	NC score	0.752299 (rank : 551)
Query Neighborhood Hits	1580	Target Neighborhood Hits	765	Shared Neighborhood Hits	722
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

ACTN1_HUMAN
θ value	0.00665767 (rank : 1012)	NC score	0.116920 (rank : 1323)
Query Neighborhood Hits	1580	Target Neighborhood Hits	221	Shared Neighborhood Hits	104
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

ACTN1_MOUSE
θ value	0.00665767 (rank : 1013)	NC score	0.115096 (rank : 1336)
Query Neighborhood Hits	1580	Target Neighborhood Hits	216	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

AKAP9_HUMAN
θ value	0.00665767 (rank : 1014)	NC score	0.152665 (rank : 1034)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1710	Shared Neighborhood Hits	396
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

GOGA1_HUMAN
θ value	0.00665767 (rank : 1015)	NC score	0.146827 (rank : 1068)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1222	Shared Neighborhood Hits	354
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

KIT_HUMAN
θ value	0.00665767 (rank : 1016)	NC score	0.589390 (rank : 773)
Query Neighborhood Hits	1580	Target Neighborhood Hits	953	Shared Neighborhood Hits	896
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	0.00665767 (rank : 1017)	NC score	0.588521 (rank : 776)
Query Neighborhood Hits	1580	Target Neighborhood Hits	949	Shared Neighborhood Hits	901
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

LRRC4_MOUSE
θ value	0.00665767 (rank : 1018)	NC score	0.074611 (rank : 1666)
Query Neighborhood Hits	1580	Target Neighborhood Hits	412	Shared Neighborhood Hits	159
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

NEGR1_MOUSE
θ value	0.00665767 (rank : 1019)	NC score	0.172781 (rank : 986)
Query Neighborhood Hits	1580	Target Neighborhood Hits	349	Shared Neighborhood Hits	237
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

REST_HUMAN
θ value	0.00665767 (rank : 1020)	NC score	0.142207 (rank : 1101)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1605	Shared Neighborhood Hits	385
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

ACV1B_HUMAN
θ value	0.00869519 (rank : 1021)	NC score	0.585733 (rank : 780)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	733
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

ACV1B_MOUSE
θ value	0.00869519 (rank : 1022)	NC score	0.585914 (rank : 779)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	732
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ARHG2_HUMAN
θ value	0.00869519 (rank : 1023)	NC score	0.151711 (rank : 1038)
Query Neighborhood Hits	1580	Target Neighborhood Hits	142	Shared Neighborhood Hits	96
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	0.00869519 (rank : 1024)	NC score	0.157110 (rank : 1012)
Query Neighborhood Hits	1580	Target Neighborhood Hits	120	Shared Neighborhood Hits	86
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

CI096_HUMAN
θ value	0.00869519 (rank : 1025)	NC score	0.786882 (rank : 489)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	785
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

DZIP1_MOUSE
θ value	0.00869519 (rank : 1026)	NC score	0.075041 (rank : 1660)
Query Neighborhood Hits	1580	Target Neighborhood Hits	530	Shared Neighborhood Hits	173
SwissProt Accessions	Q8BMD2, Q6ZQ10, Q9CRK5	Gene names	Dzip1, Kiaa0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog).

ERC2_MOUSE
θ value	0.00869519 (rank : 1027)	NC score	0.141884 (rank : 1106)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1166	Shared Neighborhood Hits	334
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

GCC2_MOUSE
θ value	0.00869519 (rank : 1028)	NC score	0.151936 (rank : 1036)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1619	Shared Neighborhood Hits	382
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

IRAK3_HUMAN
θ value	0.00869519 (rank : 1029)	NC score	0.591080 (rank : 771)
Query Neighborhood Hits	1580	Target Neighborhood Hits	644	Shared Neighborhood Hits	613
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

LTK_MOUSE
θ value	0.00869519 (rank : 1030)	NC score	0.577831 (rank : 786)
Query Neighborhood Hits	1580	Target Neighborhood Hits	770	Shared Neighborhood Hits	721
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

LUZP1_MOUSE
θ value	0.00869519 (rank : 1031)	NC score	0.127474 (rank : 1233)
Query Neighborhood Hits	1580	Target Neighborhood Hits	940	Shared Neighborhood Hits	307
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

NGEF_HUMAN
θ value	0.00869519 (rank : 1032)	NC score	0.165153 (rank : 997)
Query Neighborhood Hits	1580	Target Neighborhood Hits	166	Shared Neighborhood Hits	102
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

TGFR1_HUMAN
θ value	0.00869519 (rank : 1033)	NC score	0.589276 (rank : 774)
Query Neighborhood Hits	1580	Target Neighborhood Hits	755	Shared Neighborhood Hits	730
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
θ value	0.00869519 (rank : 1034)	NC score	0.589005 (rank : 775)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	730
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

CHL1_HUMAN
θ value	0.0113563 (rank : 1035)	NC score	0.176991 (rank : 978)
Query Neighborhood Hits	1580	Target Neighborhood Hits	413	Shared Neighborhood Hits	258
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

MOES_MOUSE
θ value	0.0113563 (rank : 1036)	NC score	0.091337 (rank : 1511)
Query Neighborhood Hits	1580	Target Neighborhood Hits	923	Shared Neighborhood Hits	296
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

MYH14_MOUSE
θ value	0.0113563 (rank : 1037)	NC score	0.138403 (rank : 1140)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1225	Shared Neighborhood Hits	351
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PCNT_HUMAN
θ value	0.0113563 (rank : 1038)	NC score	0.145871 (rank : 1074)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1551	Shared Neighborhood Hits	389
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

RPKL1_HUMAN
θ value	0.0113563 (rank : 1039)	NC score	0.708623 (rank : 582)
Query Neighborhood Hits	1580	Target Neighborhood Hits	708	Shared Neighborhood Hits	650
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

STK16_MOUSE
θ value	0.0113563 (rank : 1040)	NC score	0.802313 (rank : 423)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	791
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

ACTN3_HUMAN
θ value	0.0148317 (rank : 1041)	NC score	0.114977 (rank : 1338)
Query Neighborhood Hits	1580	Target Neighborhood Hits	272	Shared Neighborhood Hits	129
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ARHG1_MOUSE
θ value	0.0148317 (rank : 1042)	NC score	0.139827 (rank : 1128)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	93
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGF_HUMAN
θ value	0.0148317 (rank : 1043)	NC score	0.149736 (rank : 1048)
Query Neighborhood Hits	1580	Target Neighborhood Hits	214	Shared Neighborhood Hits	101
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

CING_HUMAN
θ value	0.0148317 (rank : 1044)	NC score	0.152010 (rank : 1035)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1275	Shared Neighborhood Hits	354
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

CYTSA_HUMAN
θ value	0.0148317 (rank : 1045)	NC score	0.145728 (rank : 1076)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1138	Shared Neighborhood Hits	348
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

ES8L2_MOUSE
θ value	0.0148317 (rank : 1046)	NC score	0.061907 (rank : 1811)
Query Neighborhood Hits	1580	Target Neighborhood Hits	169	Shared Neighborhood Hits	82
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

KIRR1_HUMAN
θ value	0.0148317 (rank : 1047)	NC score	0.128333 (rank : 1219)
Query Neighborhood Hits	1580	Target Neighborhood Hits	401	Shared Neighborhood Hits	203
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

LRC24_HUMAN
θ value	0.0148317 (rank : 1048)	NC score	0.088715 (rank : 1528)
Query Neighborhood Hits	1580	Target Neighborhood Hits	404	Shared Neighborhood Hits	183
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

MY18A_MOUSE
θ value	0.0148317 (rank : 1049)	NC score	0.141755 (rank : 1111)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1989	Shared Neighborhood Hits	420
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NIN_HUMAN
θ value	0.0148317 (rank : 1050)	NC score	0.148270 (rank : 1059)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1416	Shared Neighborhood Hits	361
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

NRCAM_MOUSE
θ value	0.0148317 (rank : 1051)	NC score	0.181733 (rank : 961)
Query Neighborhood Hits	1580	Target Neighborhood Hits	432	Shared Neighborhood Hits	268
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

OBSL1_HUMAN
θ value	0.0148317 (rank : 1052)	NC score	0.202541 (rank : 890)
Query Neighborhood Hits	1580	Target Neighborhood Hits	354	Shared Neighborhood Hits	235
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

PCNT_MOUSE
θ value	0.0148317 (rank : 1053)	NC score	0.145089 (rank : 1080)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1207	Shared Neighborhood Hits	338
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

SDCG8_HUMAN
θ value	0.0148317 (rank : 1054)	NC score	0.147850 (rank : 1061)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1002	Shared Neighborhood Hits	331
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

ACTN4_MOUSE
θ value	0.0193708 (rank : 1055)	NC score	0.122863 (rank : 1267)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	139
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

COG3_HUMAN
θ value	0.0193708 (rank : 1056)	NC score	0.031141 (rank : 2062)
Query Neighborhood Hits	1580	Target Neighborhood Hits	56	Shared Neighborhood Hits	30
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

FSTL5_HUMAN
θ value	0.0193708 (rank : 1057)	NC score	0.157010 (rank : 1013)
Query Neighborhood Hits	1580	Target Neighborhood Hits	347	Shared Neighborhood Hits	224
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

ILK1_HUMAN
θ value	0.0193708 (rank : 1058)	NC score	0.400847 (rank : 833)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	574
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

IWS1_MOUSE
θ value	0.0193708 (rank : 1059)	NC score	0.019522 (rank : 2092)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1258	Shared Neighborhood Hits	160
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LMNB1_MOUSE
θ value	0.0193708 (rank : 1060)	NC score	0.078594 (rank : 1626)
Query Neighborhood Hits	1580	Target Neighborhood Hits	719	Shared Neighborhood Hits	271
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

MOES_HUMAN
θ value	0.0193708 (rank : 1061)	NC score	0.089914 (rank : 1522)
Query Neighborhood Hits	1580	Target Neighborhood Hits	892	Shared Neighborhood Hits	300
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

RGS3_MOUSE
θ value	0.0193708 (rank : 1062)	NC score	0.033736 (rank : 2055)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1621	Shared Neighborhood Hits	213
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RIPK2_MOUSE
θ value	0.0193708 (rank : 1063)	NC score	0.689436 (rank : 600)
Query Neighborhood Hits	1580	Target Neighborhood Hits	776	Shared Neighborhood Hits	739
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

VCAM1_MOUSE
θ value	0.0193708 (rank : 1064)	NC score	0.158801 (rank : 1009)
Query Neighborhood Hits	1580	Target Neighborhood Hits	320	Shared Neighborhood Hits	219
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

BPAEA_MOUSE
θ value	0.0252991 (rank : 1065)	NC score	0.152736 (rank : 1032)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1480	Shared Neighborhood Hits	372
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CK5P2_MOUSE
θ value	0.0252991 (rank : 1066)	NC score	0.134362 (rank : 1172)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1151	Shared Neighborhood Hits	342
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

ES8L2_HUMAN
θ value	0.0252991 (rank : 1067)	NC score	0.062723 (rank : 1798)
Query Neighborhood Hits	1580	Target Neighborhood Hits	193	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FSTL4_MOUSE
θ value	0.0252991 (rank : 1068)	NC score	0.155339 (rank : 1019)
Query Neighborhood Hits	1580	Target Neighborhood Hits	333	Shared Neighborhood Hits	222
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

ICAM5_MOUSE
θ value	0.0252991 (rank : 1069)	NC score	0.138938 (rank : 1134)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	211
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

ILK_MOUSE
θ value	0.0252991 (rank : 1070)	NC score	0.398448 (rank : 834)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	575
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

KIRR1_MOUSE
θ value	0.0252991 (rank : 1071)	NC score	0.126722 (rank : 1240)
Query Neighborhood Hits	1580	Target Neighborhood Hits	403	Shared Neighborhood Hits	200
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

OPTN_MOUSE
θ value	0.0252991 (rank : 1072)	NC score	0.130058 (rank : 1209)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1120	Shared Neighborhood Hits	332
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

PGFRB_HUMAN
θ value	0.0252991 (rank : 1073)	NC score	0.593048 (rank : 768)
Query Neighborhood Hits	1580	Target Neighborhood Hits	962	Shared Neighborhood Hits	895
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

RPGR1_HUMAN
θ value	0.0252991 (rank : 1074)	NC score	0.117640 (rank : 1312)
Query Neighborhood Hits	1580	Target Neighborhood Hits	578	Shared Neighborhood Hits	244
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SYCP1_MOUSE
θ value	0.0252991 (rank : 1075)	NC score	0.137019 (rank : 1153)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1456	Shared Neighborhood Hits	370
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

ACTN4_HUMAN
θ value	0.0330416 (rank : 1076)	NC score	0.120408 (rank : 1287)
Query Neighborhood Hits	1580	Target Neighborhood Hits	279	Shared Neighborhood Hits	141
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

CDC7_HUMAN
θ value	0.0330416 (rank : 1077)	NC score	0.685352 (rank : 608)
Query Neighborhood Hits	1580	Target Neighborhood Hits	652	Shared Neighborhood Hits	625
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

CDC7_MOUSE
θ value	0.0330416 (rank : 1078)	NC score	0.682291 (rank : 616)
Query Neighborhood Hits	1580	Target Neighborhood Hits	641	Shared Neighborhood Hits	621
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

CING_MOUSE
θ value	0.0330416 (rank : 1079)	NC score	0.150478 (rank : 1039)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1432	Shared Neighborhood Hits	367
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

GRAP1_MOUSE
θ value	0.0330416 (rank : 1080)	NC score	0.145819 (rank : 1075)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1234	Shared Neighborhood Hits	350
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

KTN1_MOUSE
θ value	0.0330416 (rank : 1081)	NC score	0.150091 (rank : 1044)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1324	Shared Neighborhood Hits	361
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

NPHP1_HUMAN
θ value	0.0330416 (rank : 1082)	NC score	0.092532 (rank : 1501)
Query Neighborhood Hits	1580	Target Neighborhood Hits	288	Shared Neighborhood Hits	132
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

OGFR_HUMAN
θ value	0.0330416 (rank : 1083)	NC score	0.033981 (rank : 2054)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1582	Shared Neighborhood Hits	204
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

CEA20_HUMAN
θ value	0.0431538 (rank : 1084)	NC score	0.115856 (rank : 1332)
Query Neighborhood Hits	1580	Target Neighborhood Hits	251	Shared Neighborhood Hits	168
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

CP135_MOUSE
θ value	0.0431538 (rank : 1085)	NC score	0.144331 (rank : 1086)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1278	Shared Neighborhood Hits	351
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CSF1R_HUMAN
θ value	0.0431538 (rank : 1086)	NC score	0.558510 (rank : 800)
Query Neighborhood Hits	1580	Target Neighborhood Hits	943	Shared Neighborhood Hits	891
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	0.0431538 (rank : 1087)	NC score	0.563494 (rank : 797)
Query Neighborhood Hits	1580	Target Neighborhood Hits	983	Shared Neighborhood Hits	912
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

FGRL1_HUMAN
θ value	0.0431538 (rank : 1088)	NC score	0.191741 (rank : 918)
Query Neighborhood Hits	1580	Target Neighborhood Hits	335	Shared Neighborhood Hits	234
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

K2C3_HUMAN
θ value	0.0431538 (rank : 1089)	NC score	0.028682 (rank : 2065)
Query Neighborhood Hits	1580	Target Neighborhood Hits	443	Shared Neighborhood Hits	180
SwissProt Accessions	P12035, Q701L8	Gene names	KRT3
Domain Architecture
Description	Keratin, type II cytoskeletal 3 (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (65 kDa cytokeratin).

KIF5C_MOUSE
θ value	0.0431538 (rank : 1090)	NC score	0.090765 (rank : 1514)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1040	Shared Neighborhood Hits	327
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KTN1_HUMAN
θ value	0.0431538 (rank : 1091)	NC score	0.148869 (rank : 1054)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1197	Shared Neighborhood Hits	342
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

LTK_HUMAN
θ value	0.0431538 (rank : 1092)	NC score	0.569974 (rank : 793)
Query Neighborhood Hits	1580	Target Neighborhood Hits	774	Shared Neighborhood Hits	730
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

MY18A_HUMAN
θ value	0.0431538 (rank : 1093)	NC score	0.144827 (rank : 1081)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1929	Shared Neighborhood Hits	412
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

RB6I2_HUMAN
θ value	0.0431538 (rank : 1094)	NC score	0.144672 (rank : 1084)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1584	Shared Neighborhood Hits	377
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

ROBO4_MOUSE
θ value	0.0431538 (rank : 1095)	NC score	0.167970 (rank : 992)
Query Neighborhood Hits	1580	Target Neighborhood Hits	358	Shared Neighborhood Hits	234
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

RYK_HUMAN
θ value	0.0431538 (rank : 1096)	NC score	0.505191 (rank : 815)
Query Neighborhood Hits	1580	Target Neighborhood Hits	701	Shared Neighborhood Hits	675
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	0.0431538 (rank : 1097)	NC score	0.519417 (rank : 813)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	686
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SDCG8_MOUSE
θ value	0.0431538 (rank : 1098)	NC score	0.136489 (rank : 1157)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	304
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

TUFT1_HUMAN
θ value	0.0431538 (rank : 1099)	NC score	0.118949 (rank : 1303)
Query Neighborhood Hits	1580	Target Neighborhood Hits	686	Shared Neighborhood Hits	281
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

AMOL1_MOUSE
θ value	0.0563607 (rank : 1100)	NC score	0.088511 (rank : 1531)
Query Neighborhood Hits	1580	Target Neighborhood Hits	445	Shared Neighborhood Hits	205
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

APOE_MOUSE
θ value	0.0563607 (rank : 1101)	NC score	0.096295 (rank : 1473)
Query Neighborhood Hits	1580	Target Neighborhood Hits	319	Shared Neighborhood Hits	162
SwissProt Accessions	P08226	Gene names	Apoe
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

EP15_MOUSE
θ value	0.0563607 (rank : 1102)	NC score	0.106341 (rank : 1400)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	287
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

FLIP1_HUMAN
θ value	0.0563607 (rank : 1103)	NC score	0.140095 (rank : 1126)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1405	Shared Neighborhood Hits	360
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FYCO1_MOUSE
θ value	0.0563607 (rank : 1104)	NC score	0.147609 (rank : 1062)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1059	Shared Neighborhood Hits	334
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

GRAP1_HUMAN
θ value	0.0563607 (rank : 1105)	NC score	0.149166 (rank : 1052)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	317
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

IWS1_HUMAN
θ value	0.0563607 (rank : 1106)	NC score	0.025290 (rank : 2080)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1241	Shared Neighborhood Hits	175
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MYH9_HUMAN
θ value	0.0563607 (rank : 1107)	NC score	0.137662 (rank : 1145)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1762	Shared Neighborhood Hits	390
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RN5A_HUMAN
θ value	0.0563607 (rank : 1108)	NC score	0.143516 (rank : 1094)
Query Neighborhood Hits	1580	Target Neighborhood Hits	608	Shared Neighborhood Hits	331
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RN5A_MOUSE
θ value	0.0563607 (rank : 1109)	NC score	0.308648 (rank : 847)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	603
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

TGFR2_HUMAN
θ value	0.0563607 (rank : 1110)	NC score	0.615520 (rank : 742)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	723
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_MOUSE
θ value	0.0563607 (rank : 1111)	NC score	0.615716 (rank : 741)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	724
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

BIN1_HUMAN
θ value	0.0736092 (rank : 1112)	NC score	0.041929 (rank : 2042)
Query Neighborhood Hits	1580	Target Neighborhood Hits	335	Shared Neighborhood Hits	97
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BUB1_HUMAN
θ value	0.0736092 (rank : 1113)	NC score	0.416418 (rank : 831)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	415
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

CEP63_HUMAN
θ value	0.0736092 (rank : 1114)	NC score	0.148662 (rank : 1056)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1005	Shared Neighborhood Hits	331
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CI094_HUMAN
θ value	0.0736092 (rank : 1115)	NC score	0.133973 (rank : 1175)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	200
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

CJ118_HUMAN
θ value	0.0736092 (rank : 1116)	NC score	0.136418 (rank : 1159)
Query Neighborhood Hits	1580	Target Neighborhood Hits	937	Shared Neighborhood Hits	316
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

CR034_HUMAN
θ value	0.0736092 (rank : 1117)	NC score	0.122621 (rank : 1269)
Query Neighborhood Hits	1580	Target Neighborhood Hits	538	Shared Neighborhood Hits	248
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

HELZ_HUMAN
θ value	0.0736092 (rank : 1118)	NC score	0.010427 (rank : 2129)
Query Neighborhood Hits	1580	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

IBP7_MOUSE
θ value	0.0736092 (rank : 1119)	NC score	0.129664 (rank : 1211)
Query Neighborhood Hits	1580	Target Neighborhood Hits	230	Shared Neighborhood Hits	154
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

MAG_HUMAN
θ value	0.0736092 (rank : 1120)	NC score	0.154151 (rank : 1023)
Query Neighborhood Hits	1580	Target Neighborhood Hits	278	Shared Neighborhood Hits	212
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

PGFRB_MOUSE
θ value	0.0736092 (rank : 1121)	NC score	0.593595 (rank : 767)
Query Neighborhood Hits	1580	Target Neighborhood Hits	960	Shared Neighborhood Hits	892
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

TANK_MOUSE
θ value	0.0736092 (rank : 1122)	NC score	0.029825 (rank : 2063)
Query Neighborhood Hits	1580	Target Neighborhood Hits	80	Shared Neighborhood Hits	44
SwissProt Accessions	P70347, Q61178	Gene names	Tank, Itraf
Domain Architecture
Description	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF).

TBCD2_HUMAN
θ value	0.0736092 (rank : 1123)	NC score	0.051464 (rank : 1992)
Query Neighborhood Hits	1580	Target Neighborhood Hits	419	Shared Neighborhood Hits	161
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

TMCC2_MOUSE
θ value	0.0736092 (rank : 1124)	NC score	0.028062 (rank : 2067)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	117
SwissProt Accessions	Q80W04, Q6A061	Gene names	Tmcc2, Kiaa0481
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 2.

ACTN2_HUMAN
θ value	0.0961366 (rank : 1125)	NC score	0.116242 (rank : 1327)
Query Neighborhood Hits	1580	Target Neighborhood Hits	295	Shared Neighborhood Hits	143
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

ACTN2_MOUSE
θ value	0.0961366 (rank : 1126)	NC score	0.113982 (rank : 1346)
Query Neighborhood Hits	1580	Target Neighborhood Hits	287	Shared Neighborhood Hits	138
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

AMGO2_MOUSE
θ value	0.0961366 (rank : 1127)	NC score	0.047132 (rank : 2029)
Query Neighborhood Hits	1580	Target Neighborhood Hits	329	Shared Neighborhood Hits	100
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

AMOL1_HUMAN
θ value	0.0961366 (rank : 1128)	NC score	0.093020 (rank : 1497)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	209
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

BASI_MOUSE
θ value	0.0961366 (rank : 1129)	NC score	0.134645 (rank : 1170)
Query Neighborhood Hits	1580	Target Neighborhood Hits	238	Shared Neighborhood Hits	183
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

BIN1_MOUSE
θ value	0.0961366 (rank : 1130)	NC score	0.043694 (rank : 2035)
Query Neighborhood Hits	1580	Target Neighborhood Hits	283	Shared Neighborhood Hits	105
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CEP68_HUMAN
θ value	0.0961366 (rank : 1131)	NC score	0.027193 (rank : 2072)
Query Neighborhood Hits	1580	Target Neighborhood Hits	128	Shared Neighborhood Hits	42
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

FGRL1_MOUSE
θ value	0.0961366 (rank : 1132)	NC score	0.191403 (rank : 920)
Query Neighborhood Hits	1580	Target Neighborhood Hits	325	Shared Neighborhood Hits	234
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

GOGA1_MOUSE
θ value	0.0961366 (rank : 1133)	NC score	0.143914 (rank : 1091)
Query Neighborhood Hits	1580	Target Neighborhood Hits	994	Shared Neighborhood Hits	336
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

ICAM5_HUMAN
θ value	0.0961366 (rank : 1134)	NC score	0.133565 (rank : 1182)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	205
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

KI20A_HUMAN
θ value	0.0961366 (rank : 1135)	NC score	0.041170 (rank : 2044)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	160
SwissProt Accessions	O95235	Gene names	KIF20A, RAB6KIFL
Domain Architecture
Description	Kinesin family member 20A (Rabkinesin-6) (Rab6-interacting kinesin- like protein) (GG10_2).

NCOA1_MOUSE
θ value	0.0961366 (rank : 1136)	NC score	0.007779 (rank : 2149)
Query Neighborhood Hits	1580	Target Neighborhood Hits	196	Shared Neighborhood Hits	37
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

RIPK4_HUMAN
θ value	0.0961366 (rank : 1137)	NC score	0.571852 (rank : 792)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1094	Shared Neighborhood Hits	781
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

SRRM2_MOUSE
θ value	0.0961366 (rank : 1138)	NC score	0.059335 (rank : 1856)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1470	Shared Neighborhood Hits	243
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

UFO_HUMAN
θ value	0.0961366 (rank : 1139)	NC score	0.614158 (rank : 747)
Query Neighborhood Hits	1580	Target Neighborhood Hits	981	Shared Neighborhood Hits	848
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ALK_MOUSE
θ value	0.125558 (rank : 1140)	NC score	0.577149 (rank : 788)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	726
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

BSN_MOUSE
θ value	0.125558 (rank : 1141)	NC score	0.065259 (rank : 1768)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2057	Shared Neighborhood Hits	375
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

FSTL5_MOUSE
θ value	0.125558 (rank : 1142)	NC score	0.152684 (rank : 1033)
Query Neighborhood Hits	1580	Target Neighborhood Hits	355	Shared Neighborhood Hits	221
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

GUC2D_HUMAN
θ value	0.125558 (rank : 1143)	NC score	0.449654 (rank : 820)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	653
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

GUC2F_HUMAN
θ value	0.125558 (rank : 1144)	NC score	0.494099 (rank : 816)
Query Neighborhood Hits	1580	Target Neighborhood Hits	740	Shared Neighborhood Hits	667
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ILK2_HUMAN
θ value	0.125558 (rank : 1145)	NC score	0.388602 (rank : 837)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	568
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

IRAK2_HUMAN
θ value	0.125558 (rank : 1146)	NC score	0.626381 (rank : 718)
Query Neighborhood Hits	1580	Target Neighborhood Hits	714	Shared Neighborhood Hits	662
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

LAMC1_HUMAN
θ value	0.125558 (rank : 1147)	NC score	0.062746 (rank : 1797)
Query Neighborhood Hits	1580	Target Neighborhood Hits	922	Shared Neighborhood Hits	272
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LMNB1_HUMAN
θ value	0.125558 (rank : 1148)	NC score	0.078862 (rank : 1624)
Query Neighborhood Hits	1580	Target Neighborhood Hits	714	Shared Neighborhood Hits	275
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

MD1L1_HUMAN
θ value	0.125558 (rank : 1149)	NC score	0.144721 (rank : 1083)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	313
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

NACAM_MOUSE
θ value	0.125558 (rank : 1150)	NC score	0.047071 (rank : 2030)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1866	Shared Neighborhood Hits	249
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCK1_HUMAN
θ value	0.125558 (rank : 1151)	NC score	0.129363 (rank : 1215)
Query Neighborhood Hits	1580	Target Neighborhood Hits	312	Shared Neighborhood Hits	113
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

SNX23_HUMAN
θ value	0.125558 (rank : 1152)	NC score	0.090869 (rank : 1513)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	316
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

ARHG1_HUMAN
θ value	0.163984 (rank : 1153)	NC score	0.147053 (rank : 1066)
Query Neighborhood Hits	1580	Target Neighborhood Hits	176	Shared Neighborhood Hits	83
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

AZI1_HUMAN
θ value	0.163984 (rank : 1154)	NC score	0.141312 (rank : 1116)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1000	Shared Neighborhood Hits	312
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

BRE1A_MOUSE
θ value	0.163984 (rank : 1155)	NC score	0.127406 (rank : 1236)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1025	Shared Neighborhood Hits	297
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CASP_HUMAN
θ value	0.163984 (rank : 1156)	NC score	0.127876 (rank : 1227)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1131	Shared Neighborhood Hits	330
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CD22_MOUSE
θ value	0.163984 (rank : 1157)	NC score	0.132341 (rank : 1188)
Query Neighborhood Hits	1580	Target Neighborhood Hits	331	Shared Neighborhood Hits	196
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CEAM1_MOUSE
θ value	0.163984 (rank : 1158)	NC score	0.117373 (rank : 1315)
Query Neighborhood Hits	1580	Target Neighborhood Hits	326	Shared Neighborhood Hits	210
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

EP15R_HUMAN
θ value	0.163984 (rank : 1159)	NC score	0.113452 (rank : 1351)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1083	Shared Neighborhood Hits	330
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

GCC1_HUMAN
θ value	0.163984 (rank : 1160)	NC score	0.124723 (rank : 1258)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	302
SwissProt Accessions	Q96CN9, Q9H6N7	Gene names	GCC1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

MAP4_MOUSE
θ value	0.163984 (rank : 1161)	NC score	0.025778 (rank : 2076)
Query Neighborhood Hits	1580	Target Neighborhood Hits	409	Shared Neighborhood Hits	86
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MD1L1_MOUSE
θ value	0.163984 (rank : 1162)	NC score	0.143902 (rank : 1092)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1001	Shared Neighborhood Hits	327
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

NCK2_HUMAN
θ value	0.163984 (rank : 1163)	NC score	0.127463 (rank : 1235)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	109
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

PCQAP_HUMAN
θ value	0.163984 (rank : 1164)	NC score	0.067555 (rank : 1746)
Query Neighborhood Hits	1580	Target Neighborhood Hits	549	Shared Neighborhood Hits	182
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PIBF1_HUMAN
θ value	0.163984 (rank : 1165)	NC score	0.149494 (rank : 1050)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1041	Shared Neighborhood Hits	336
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

RAI14_HUMAN
θ value	0.163984 (rank : 1166)	NC score	0.094911 (rank : 1483)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1367	Shared Neighborhood Hits	345
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

ACV1C_MOUSE
θ value	0.21417 (rank : 1167)	NC score	0.526649 (rank : 810)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	687
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

ATBF1_MOUSE
θ value	0.21417 (rank : 1168)	NC score	-0.013911 (rank : 2203)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1841	Shared Neighborhood Hits	176
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CK5P2_HUMAN
θ value	0.21417 (rank : 1169)	NC score	0.127143 (rank : 1237)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1433	Shared Neighborhood Hits	365
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

K1C9_HUMAN
θ value	0.21417 (rank : 1170)	NC score	0.042241 (rank : 2039)
Query Neighborhood Hits	1580	Target Neighborhood Hits	526	Shared Neighborhood Hits	234
SwissProt Accessions	P35527, O00109, Q14665	Gene names	KRT9
Domain Architecture
Description	Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9).

KS6C1_HUMAN
θ value	0.21417 (rank : 1171)	NC score	0.685381 (rank : 607)
Query Neighborhood Hits	1580	Target Neighborhood Hits	682	Shared Neighborhood Hits	636
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

KSR1_HUMAN
θ value	0.21417 (rank : 1172)	NC score	0.688227 (rank : 603)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	774
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR1_MOUSE
θ value	0.21417 (rank : 1173)	NC score	0.698336 (rank : 592)
Query Neighborhood Hits	1580	Target Neighborhood Hits	870	Shared Neighborhood Hits	789
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

MAG_MOUSE
θ value	0.21417 (rank : 1174)	NC score	0.154883 (rank : 1020)
Query Neighborhood Hits	1580	Target Neighborhood Hits	271	Shared Neighborhood Hits	211
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

MDGA1_HUMAN
θ value	0.21417 (rank : 1175)	NC score	0.162056 (rank : 1001)
Query Neighborhood Hits	1580	Target Neighborhood Hits	358	Shared Neighborhood Hits	232
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

MFA3L_MOUSE
θ value	0.21417 (rank : 1176)	NC score	0.136441 (rank : 1158)
Query Neighborhood Hits	1580	Target Neighborhood Hits	214	Shared Neighborhood Hits	183
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

RFIP3_HUMAN
θ value	0.21417 (rank : 1177)	NC score	0.114319 (rank : 1342)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1055	Shared Neighborhood Hits	330
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

RRBP1_HUMAN
θ value	0.21417 (rank : 1178)	NC score	0.120441 (rank : 1285)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1306	Shared Neighborhood Hits	347
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

SN_MOUSE
θ value	0.21417 (rank : 1179)	NC score	0.142356 (rank : 1099)
Query Neighborhood Hits	1580	Target Neighborhood Hits	416	Shared Neighborhood Hits	233
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

STK16_HUMAN
θ value	0.21417 (rank : 1180)	NC score	0.802806 (rank : 419)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	796
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

TXLNB_MOUSE
θ value	0.21417 (rank : 1181)	NC score	0.106090 (rank : 1402)
Query Neighborhood Hits	1580	Target Neighborhood Hits	640	Shared Neighborhood Hits	260
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

UFO_MOUSE
θ value	0.21417 (rank : 1182)	NC score	0.619890 (rank : 734)
Query Neighborhood Hits	1580	Target Neighborhood Hits	988	Shared Neighborhood Hits	855
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ACV1C_HUMAN
θ value	0.279714 (rank : 1183)	NC score	0.522367 (rank : 812)
Query Neighborhood Hits	1580	Target Neighborhood Hits	709	Shared Neighborhood Hits	681
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

BCL9_HUMAN
θ value	0.279714 (rank : 1184)	NC score	0.014605 (rank : 2109)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1008	Shared Neighborhood Hits	126
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CEP68_MOUSE
θ value	0.279714 (rank : 1185)	NC score	0.026045 (rank : 2075)
Query Neighborhood Hits	1580	Target Neighborhood Hits	62	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C0D9, Q3US49, Q5SW85, Q8R2V0	Gene names	Cep68
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

CROCC_MOUSE
θ value	0.279714 (rank : 1186)	NC score	0.141404 (rank : 1113)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1460	Shared Neighborhood Hits	365
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

GBP5_MOUSE
θ value	0.279714 (rank : 1187)	NC score	0.037610 (rank : 2051)
Query Neighborhood Hits	1580	Target Neighborhood Hits	254	Shared Neighborhood Hits	124
SwissProt Accessions	Q8CFB4, Q8CFA4	Gene names	Gbp5
Domain Architecture
Description	Interferon-induced guanylate-binding protein 5 (GTP-binding protein 5) (Guanine nucleotide-binding protein 5) (GBP-5) (MuGBP-5).

GOGA6_HUMAN
θ value	0.279714 (rank : 1188)	NC score	0.142795 (rank : 1097)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1007	Shared Neighborhood Hits	326
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

HMMR_HUMAN
θ value	0.279714 (rank : 1189)	NC score	0.145944 (rank : 1073)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1082	Shared Neighborhood Hits	329
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

KC1AL_HUMAN
θ value	0.279714 (rank : 1190)	NC score	0.642826 (rank : 678)
Query Neighborhood Hits	1580	Target Neighborhood Hits	734	Shared Neighborhood Hits	714
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

KC1A_HUMAN
θ value	0.279714 (rank : 1191)	NC score	0.645439 (rank : 673)
Query Neighborhood Hits	1580	Target Neighborhood Hits	728	Shared Neighborhood Hits	715
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
θ value	0.279714 (rank : 1192)	NC score	0.645439 (rank : 674)
Query Neighborhood Hits	1580	Target Neighborhood Hits	728	Shared Neighborhood Hits	715
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KI20A_MOUSE
θ value	0.279714 (rank : 1193)	NC score	0.035844 (rank : 2052)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	152
SwissProt Accessions	P97329, Q542M4	Gene names	Kif20a, Rab6kifl
Domain Architecture
Description	Kinesin family member 20A (Rabkinesin-6) (Rab6-interacting kinesin- like protein) (Kinesin-like protein 174).

LIPA1_HUMAN
θ value	0.279714 (rank : 1194)	NC score	0.118147 (rank : 1306)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1294	Shared Neighborhood Hits	344
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

MYH9_MOUSE
θ value	0.279714 (rank : 1195)	NC score	0.136659 (rank : 1156)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1829	Shared Neighborhood Hits	397
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NUCB2_HUMAN
θ value	0.279714 (rank : 1196)	NC score	0.063473 (rank : 1787)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	162
SwissProt Accessions	P80303, Q8NFT5	Gene names	NUCB2, NEFA
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA) (Gastric cancer antigen Zg4).

SEC20_MOUSE
θ value	0.279714 (rank : 1197)	NC score	0.082839 (rank : 1590)
Query Neighborhood Hits	1580	Target Neighborhood Hits	323	Shared Neighborhood Hits	177
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

SIG11_HUMAN
θ value	0.279714 (rank : 1198)	NC score	0.121547 (rank : 1276)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	208
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

SIGL5_MOUSE
θ value	0.279714 (rank : 1199)	NC score	0.096620 (rank : 1471)
Query Neighborhood Hits	1580	Target Neighborhood Hits	271	Shared Neighborhood Hits	197
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

SMC1A_HUMAN
θ value	0.279714 (rank : 1200)	NC score	0.125714 (rank : 1250)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1346	Shared Neighborhood Hits	352
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

TTC3_HUMAN
θ value	0.279714 (rank : 1201)	NC score	0.081258 (rank : 1608)
Query Neighborhood Hits	1580	Target Neighborhood Hits	664	Shared Neighborhood Hits	228
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

AHI1_HUMAN
θ value	0.365318 (rank : 1202)	NC score	0.061987 (rank : 1810)
Query Neighborhood Hits	1580	Target Neighborhood Hits	537	Shared Neighborhood Hits	121
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ALK_HUMAN
θ value	0.365318 (rank : 1203)	NC score	0.579459 (rank : 784)
Query Neighborhood Hits	1580	Target Neighborhood Hits	795	Shared Neighborhood Hits	719
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

AMGO2_HUMAN
θ value	0.365318 (rank : 1204)	NC score	0.050375 (rank : 2014)
Query Neighborhood Hits	1580	Target Neighborhood Hits	357	Shared Neighborhood Hits	123
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

ESAM_MOUSE
θ value	0.365318 (rank : 1205)	NC score	0.082252 (rank : 1601)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	150
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

HC127_HUMAN
θ value	0.365318 (rank : 1206)	NC score	0.084784 (rank : 1562)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NQZ6, Q5JTF9, Q9H9C3, Q9H9H7, Q9ULQ4	Gene names	HCA127, KIAA1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127.

HC127_MOUSE
θ value	0.365318 (rank : 1207)	NC score	0.084784 (rank : 1563)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	157
SwissProt Accessions	Q68FG0, Q6ZPW6	Gene names	Hca127, Kiaa1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127 homolog.

JAM3_MOUSE
θ value	0.365318 (rank : 1208)	NC score	0.136860 (rank : 1154)
Query Neighborhood Hits	1580	Target Neighborhood Hits	286	Shared Neighborhood Hits	197
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

KI21A_MOUSE
θ value	0.365318 (rank : 1209)	NC score	0.060673 (rank : 1836)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1317	Shared Neighborhood Hits	318
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

PARVB_MOUSE
θ value	0.365318 (rank : 1210)	NC score	0.027653 (rank : 2071)
Query Neighborhood Hits	1580	Target Neighborhood Hits	43	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ES46	Gene names	Parvb
Domain Architecture
Description	Beta-parvin.

RABE1_HUMAN
θ value	0.365318 (rank : 1211)	NC score	0.137656 (rank : 1146)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1104	Shared Neighborhood Hits	330
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

RABE1_MOUSE
θ value	0.365318 (rank : 1212)	NC score	0.135874 (rank : 1161)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1105	Shared Neighborhood Hits	338
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

RBCC1_HUMAN
θ value	0.365318 (rank : 1213)	NC score	0.140981 (rank : 1121)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1023	Shared Neighborhood Hits	330
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

SMC3_HUMAN
θ value	0.365318 (rank : 1214)	NC score	0.128305 (rank : 1220)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1186	Shared Neighborhood Hits	340
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	0.365318 (rank : 1215)	NC score	0.128288 (rank : 1221)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1187	Shared Neighborhood Hits	341
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SN_HUMAN
θ value	0.365318 (rank : 1216)	NC score	0.139521 (rank : 1131)
Query Neighborhood Hits	1580	Target Neighborhood Hits	434	Shared Neighborhood Hits	228
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

SRBS1_HUMAN
θ value	0.365318 (rank : 1217)	NC score	0.078711 (rank : 1625)
Query Neighborhood Hits	1580	Target Neighborhood Hits	396	Shared Neighborhood Hits	131
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SYCC_HUMAN
θ value	0.365318 (rank : 1218)	NC score	0.012896 (rank : 2117)
Query Neighborhood Hits	1580	Target Neighborhood Hits	51	Shared Neighborhood Hits	22
SwissProt Accessions	P49589, Q53XI8, Q9HD24, Q9HD25	Gene names	CARS
Domain Architecture
Description	Cysteinyl-tRNA synthetase, cytoplasmic (EC 6.1.1.16) (Cysteine--tRNA ligase) (CysRS).

TMF1_HUMAN
θ value	0.365318 (rank : 1219)	NC score	0.136193 (rank : 1160)
Query Neighborhood Hits	1580	Target Neighborhood Hits	987	Shared Neighborhood Hits	309
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

TRAK1_HUMAN
θ value	0.365318 (rank : 1220)	NC score	0.111375 (rank : 1363)
Query Neighborhood Hits	1580	Target Neighborhood Hits	660	Shared Neighborhood Hits	273
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

X3CL1_HUMAN
θ value	0.365318 (rank : 1221)	NC score	0.008141 (rank : 2145)
Query Neighborhood Hits	1580	Target Neighborhood Hits	152	Shared Neighborhood Hits	21
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

CCD91_MOUSE
θ value	0.47712 (rank : 1222)	NC score	0.120416 (rank : 1286)
Query Neighborhood Hits	1580	Target Neighborhood Hits	699	Shared Neighborhood Hits	266
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

COG3_MOUSE
θ value	0.47712 (rank : 1223)	NC score	0.025754 (rank : 2077)
Query Neighborhood Hits	1580	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CI04	Gene names	Cog3
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 3.

EGR4_MOUSE
θ value	0.47712 (rank : 1224)	NC score	-0.028478 (rank : 2214)
Query Neighborhood Hits	1580	Target Neighborhood Hits	710	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WUF2	Gene names	Egr4
Domain Architecture
Description	Early growth response protein 4 (EGR-4).

GRAP_HUMAN
θ value	0.47712 (rank : 1225)	NC score	0.133247 (rank : 1184)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	109
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRIN1_HUMAN
θ value	0.47712 (rank : 1226)	NC score	0.028239 (rank : 2066)
Query Neighborhood Hits	1580	Target Neighborhood Hits	681	Shared Neighborhood Hits	105
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

KI21A_HUMAN
θ value	0.47712 (rank : 1227)	NC score	0.065967 (rank : 1761)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1543	Shared Neighborhood Hits	341
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

LIPB2_MOUSE
θ value	0.47712 (rank : 1228)	NC score	0.085130 (rank : 1559)
Query Neighborhood Hits	1580	Target Neighborhood Hits	570	Shared Neighborhood Hits	242
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

NEMO_HUMAN
θ value	0.47712 (rank : 1229)	NC score	0.123879 (rank : 1262)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	309
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

P66A_MOUSE
θ value	0.47712 (rank : 1230)	NC score	0.008331 (rank : 2144)
Query Neighborhood Hits	1580	Target Neighborhood Hits	58	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CHY6, Q8BTQ2, Q8VEC9	Gene names	Gatad2a
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (GATA zinc finger domain- containing protein 2A).

RRBP1_MOUSE
θ value	0.47712 (rank : 1231)	NC score	0.117130 (rank : 1319)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1650	Shared Neighborhood Hits	374
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

SAS6_HUMAN
θ value	0.47712 (rank : 1232)	NC score	0.119692 (rank : 1293)
Query Neighborhood Hits	1580	Target Neighborhood Hits	791	Shared Neighborhood Hits	282
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

VSIG2_HUMAN
θ value	0.47712 (rank : 1233)	NC score	0.130459 (rank : 1206)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	196
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

BRD8_MOUSE
θ value	0.62314 (rank : 1234)	NC score	0.009488 (rank : 2136)
Query Neighborhood Hits	1580	Target Neighborhood Hits	422	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

C102B_HUMAN
θ value	0.62314 (rank : 1235)	NC score	0.119143 (rank : 1300)
Query Neighborhood Hits	1580	Target Neighborhood Hits	542	Shared Neighborhood Hits	232
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

EMB_MOUSE
θ value	0.62314 (rank : 1236)	NC score	0.072163 (rank : 1694)
Query Neighborhood Hits	1580	Target Neighborhood Hits	83	Shared Neighborhood Hits	72
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

GUC2G_MOUSE
θ value	0.62314 (rank : 1237)	NC score	0.422398 (rank : 829)
Query Neighborhood Hits	1580	Target Neighborhood Hits	644	Shared Neighborhood Hits	569
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

IFT81_MOUSE
θ value	0.62314 (rank : 1238)	NC score	0.137618 (rank : 1148)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	318
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

LAMA1_HUMAN
θ value	0.62314 (rank : 1239)	NC score	0.031303 (rank : 2061)
Query Neighborhood Hits	1580	Target Neighborhood Hits	804	Shared Neighborhood Hits	214
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

LAMA4_HUMAN
θ value	0.62314 (rank : 1240)	NC score	0.068720 (rank : 1732)
Query Neighborhood Hits	1580	Target Neighborhood Hits	708	Shared Neighborhood Hits	224
SwissProt Accessions	Q16363, Q14735, Q15335, Q4LE44, Q5SZG8, Q9UE18, Q9UJN9	Gene names	LAMA4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

LAMA4_MOUSE
θ value	0.62314 (rank : 1241)	NC score	0.052564 (rank : 1974)
Query Neighborhood Hits	1580	Target Neighborhood Hits	584	Shared Neighborhood Hits	193
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

NOTC2_MOUSE
θ value	0.62314 (rank : 1242)	NC score	-0.006480 (rank : 2195)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1069	Shared Neighborhood Hits	72
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

REXO1_HUMAN
θ value	0.62314 (rank : 1243)	NC score	0.014321 (rank : 2110)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

SEC20_HUMAN
θ value	0.62314 (rank : 1244)	NC score	0.064246 (rank : 1779)
Query Neighborhood Hits	1580	Target Neighborhood Hits	200	Shared Neighborhood Hits	127
SwissProt Accessions	Q12981, O75622, O75623, O75624, Q6K044, Q96FG4	Gene names	BNIP1, NIP1, SEC20L, TRG8
Domain Architecture
Description	Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein- interacting protein 1) (Transformation-related gene 8 protein) (TRG- 8).

SMC1A_MOUSE
θ value	0.62314 (rank : 1245)	NC score	0.127890 (rank : 1226)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1384	Shared Neighborhood Hits	355
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

TOPK_HUMAN
θ value	0.62314 (rank : 1246)	NC score	0.560708 (rank : 798)
Query Neighborhood Hits	1580	Target Neighborhood Hits	605	Shared Neighborhood Hits	576
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

VSIG2_MOUSE
θ value	0.62314 (rank : 1247)	NC score	0.126328 (rank : 1244)
Query Neighborhood Hits	1580	Target Neighborhood Hits	316	Shared Neighborhood Hits	192
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

AHI1_MOUSE
θ value	0.813845 (rank : 1248)	NC score	0.057352 (rank : 1894)
Query Neighborhood Hits	1580	Target Neighborhood Hits	496	Shared Neighborhood Hits	108
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AN30A_HUMAN
θ value	0.813845 (rank : 1249)	NC score	0.097053 (rank : 1461)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1119	Shared Neighborhood Hits	311
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

BASI_HUMAN
θ value	0.813845 (rank : 1250)	NC score	0.133968 (rank : 1176)
Query Neighborhood Hits	1580	Target Neighborhood Hits	211	Shared Neighborhood Hits	172
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

BTNL1_MOUSE
θ value	0.813845 (rank : 1251)	NC score	0.018708 (rank : 2095)
Query Neighborhood Hits	1580	Target Neighborhood Hits	151	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

CASP_MOUSE
θ value	0.813845 (rank : 1252)	NC score	0.127592 (rank : 1231)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1152	Shared Neighborhood Hits	331
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CDR2_HUMAN
θ value	0.813845 (rank : 1253)	NC score	0.095833 (rank : 1479)
Query Neighborhood Hits	1580	Target Neighborhood Hits	404	Shared Neighborhood Hits	219
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

CTGE5_HUMAN
θ value	0.813845 (rank : 1254)	NC score	0.107427 (rank : 1391)
Query Neighborhood Hits	1580	Target Neighborhood Hits	800	Shared Neighborhood Hits	291
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

ESAM_HUMAN
θ value	0.813845 (rank : 1255)	NC score	0.090311 (rank : 1515)
Query Neighborhood Hits	1580	Target Neighborhood Hits	251	Shared Neighborhood Hits	161
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

FYCO1_HUMAN
θ value	0.813845 (rank : 1256)	NC score	0.147859 (rank : 1060)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1149	Shared Neighborhood Hits	357
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

KC1G1_HUMAN
θ value	0.813845 (rank : 1257)	NC score	0.623264 (rank : 726)
Query Neighborhood Hits	1580	Target Neighborhood Hits	708	Shared Neighborhood Hits	690
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KC1G1_MOUSE
θ value	0.813845 (rank : 1258)	NC score	0.624885 (rank : 724)
Query Neighborhood Hits	1580	Target Neighborhood Hits	713	Shared Neighborhood Hits	692
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

KS6C1_MOUSE
θ value	0.813845 (rank : 1259)	NC score	0.688357 (rank : 602)
Query Neighborhood Hits	1580	Target Neighborhood Hits	700	Shared Neighborhood Hits	634
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

LRC24_MOUSE
θ value	0.813845 (rank : 1260)	NC score	0.079121 (rank : 1620)
Query Neighborhood Hits	1580	Target Neighborhood Hits	387	Shared Neighborhood Hits	180
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

MFAP3_HUMAN
θ value	0.813845 (rank : 1261)	NC score	0.054839 (rank : 1932)
Query Neighborhood Hits	1580	Target Neighborhood Hits	91	Shared Neighborhood Hits	82
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

MUC1_HUMAN
θ value	0.813845 (rank : 1262)	NC score	0.017467 (rank : 2100)
Query Neighborhood Hits	1580	Target Neighborhood Hits	975	Shared Neighborhood Hits	129
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

NPHN_HUMAN
θ value	0.813845 (rank : 1263)	NC score	0.154473 (rank : 1022)
Query Neighborhood Hits	1580	Target Neighborhood Hits	362	Shared Neighborhood Hits	226
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

PVRL2_HUMAN
θ value	0.813845 (rank : 1264)	NC score	0.043476 (rank : 2037)
Query Neighborhood Hits	1580	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

PVR_HUMAN
θ value	0.813845 (rank : 1265)	NC score	0.045976 (rank : 2031)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	104
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

SIG10_HUMAN
θ value	0.813845 (rank : 1266)	NC score	0.119636 (rank : 1294)
Query Neighborhood Hits	1580	Target Neighborhood Hits	363	Shared Neighborhood Hits	222
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

TARA_HUMAN
θ value	0.813845 (rank : 1267)	NC score	0.079826 (rank : 1616)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1626	Shared Neighborhood Hits	390
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TLE3_MOUSE
θ value	0.813845 (rank : 1268)	NC score	-0.007442 (rank : 2198)
Query Neighborhood Hits	1580	Target Neighborhood Hits	378	Shared Neighborhood Hits	36
SwissProt Accessions	Q08122, Q923A4	Gene names	Tle3, Esg
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG) (Grg-3).

TMIGD_HUMAN
θ value	0.813845 (rank : 1269)	NC score	0.148480 (rank : 1057)
Query Neighborhood Hits	1580	Target Neighborhood Hits	240	Shared Neighborhood Hits	189
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

AL2S2_MOUSE
θ value	1.06291 (rank : 1270)	NC score	0.701545 (rank : 589)
Query Neighborhood Hits	1580	Target Neighborhood Hits	709	Shared Neighborhood Hits	687
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

BCL9_MOUSE
θ value	1.06291 (rank : 1271)	NC score	0.011534 (rank : 2122)
Query Neighborhood Hits	1580	Target Neighborhood Hits	770	Shared Neighborhood Hits	110
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

BSN_HUMAN
θ value	1.06291 (rank : 1272)	NC score	0.074784 (rank : 1665)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1537	Shared Neighborhood Hits	351
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CCD62_HUMAN
θ value	1.06291 (rank : 1273)	NC score	0.134574 (rank : 1171)
Query Neighborhood Hits	1580	Target Neighborhood Hits	631	Shared Neighborhood Hits	266
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

CIC_HUMAN
θ value	1.06291 (rank : 1274)	NC score	0.015832 (rank : 2105)
Query Neighborhood Hits	1580	Target Neighborhood Hits	992	Shared Neighborhood Hits	135
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CT096_HUMAN
θ value	1.06291 (rank : 1275)	NC score	0.102776 (rank : 1422)
Query Neighborhood Hits	1580	Target Neighborhood Hits	438	Shared Neighborhood Hits	219
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

DYNA_HUMAN
θ value	1.06291 (rank : 1276)	NC score	0.118768 (rank : 1304)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1194	Shared Neighborhood Hits	350
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

DYNA_MOUSE
θ value	1.06291 (rank : 1277)	NC score	0.116746 (rank : 1325)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1084	Shared Neighborhood Hits	338
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

ERC2_HUMAN
θ value	1.06291 (rank : 1278)	NC score	0.138417 (rank : 1138)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1156	Shared Neighborhood Hits	327
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

FYV1_HUMAN
θ value	1.06291 (rank : 1279)	NC score	0.032459 (rank : 2060)
Query Neighborhood Hits	1580	Target Neighborhood Hits	217	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

GBP2_MOUSE
θ value	1.06291 (rank : 1280)	NC score	0.051813 (rank : 1984)
Query Neighborhood Hits	1580	Target Neighborhood Hits	323	Shared Neighborhood Hits	168
SwissProt Accessions	Q9Z0E6, Q8CIC6, Q921N2, Q9R1I0	Gene names	Gbp2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (mGBP2) (mGBP-2).

KC1G2_MOUSE
θ value	1.06291 (rank : 1281)	NC score	0.597584 (rank : 761)
Query Neighborhood Hits	1580	Target Neighborhood Hits	695	Shared Neighborhood Hits	677
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

KC1G3_HUMAN
θ value	1.06291 (rank : 1282)	NC score	0.620587 (rank : 731)
Query Neighborhood Hits	1580	Target Neighborhood Hits	711	Shared Neighborhood Hits	696
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

KIF4A_HUMAN
θ value	1.06291 (rank : 1283)	NC score	0.096934 (rank : 1464)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1159	Shared Neighborhood Hits	331
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

MMRN1_HUMAN
θ value	1.06291 (rank : 1284)	NC score	0.104396 (rank : 1412)
Query Neighborhood Hits	1580	Target Neighborhood Hits	636	Shared Neighborhood Hits	218
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

MYO5C_HUMAN
θ value	1.06291 (rank : 1285)	NC score	0.118990 (rank : 1302)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1206	Shared Neighborhood Hits	352
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

NCOA1_HUMAN
θ value	1.06291 (rank : 1286)	NC score	0.005326 (rank : 2157)
Query Neighborhood Hits	1580	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NIN_MOUSE
θ value	1.06291 (rank : 1287)	NC score	0.137482 (rank : 1150)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1376	Shared Neighborhood Hits	350
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

NPHN_MOUSE
θ value	1.06291 (rank : 1288)	NC score	0.148361 (rank : 1058)
Query Neighborhood Hits	1580	Target Neighborhood Hits	370	Shared Neighborhood Hits	225
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NUCB2_MOUSE
θ value	1.06291 (rank : 1289)	NC score	0.068210 (rank : 1735)
Query Neighborhood Hits	1580	Target Neighborhood Hits	459	Shared Neighborhood Hits	203
SwissProt Accessions	P81117	Gene names	Nucb2, Nefa
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA).

PALB2_MOUSE
θ value	1.06291 (rank : 1290)	NC score	0.011487 (rank : 2123)
Query Neighborhood Hits	1580	Target Neighborhood Hits	133	Shared Neighborhood Hits	27
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

STK31_HUMAN
θ value	1.06291 (rank : 1291)	NC score	0.369575 (rank : 839)
Query Neighborhood Hits	1580	Target Neighborhood Hits	570	Shared Neighborhood Hits	481
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

TCRG1_HUMAN
θ value	1.06291 (rank : 1292)	NC score	0.092032 (rank : 1508)
Query Neighborhood Hits	1580	Target Neighborhood Hits	929	Shared Neighborhood Hits	285
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	1.06291 (rank : 1293)	NC score	0.093067 (rank : 1496)
Query Neighborhood Hits	1580	Target Neighborhood Hits	947	Shared Neighborhood Hits	286
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

UACA_HUMAN
θ value	1.06291 (rank : 1294)	NC score	0.116910 (rank : 1324)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1622	Shared Neighborhood Hits	368
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

AKAP6_HUMAN
θ value	1.38821 (rank : 1295)	NC score	0.094095 (rank : 1485)
Query Neighborhood Hits	1580	Target Neighborhood Hits	263	Shared Neighborhood Hits	124
SwissProt Accessions	Q13023, O15028	Gene names	AKAP6, AKAP100, KIAA0311
Domain Architecture
Description	A-kinase anchor protein 6 (Protein kinase A-anchoring protein 6) (PRKA6) (A-kinase anchor protein 100 kDa) (AKAP 100) (mAKAP).

AMGO1_MOUSE
θ value	1.38821 (rank : 1296)	NC score	0.040211 (rank : 2047)
Query Neighborhood Hits	1580	Target Neighborhood Hits	325	Shared Neighborhood Hits	86
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

ANR11_HUMAN
θ value	1.38821 (rank : 1297)	NC score	0.033425 (rank : 2056)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1289	Shared Neighborhood Hits	256
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

AZI1_MOUSE
θ value	1.38821 (rank : 1298)	NC score	0.134792 (rank : 1168)
Query Neighborhood Hits	1580	Target Neighborhood Hits	990	Shared Neighborhood Hits	321
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

BRE1A_HUMAN
θ value	1.38821 (rank : 1299)	NC score	0.123614 (rank : 1264)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1071	Shared Neighborhood Hits	298
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

CBP_MOUSE
θ value	1.38821 (rank : 1300)	NC score	0.012987 (rank : 2116)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1051	Shared Neighborhood Hits	148
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CCD39_MOUSE
θ value	1.38821 (rank : 1301)	NC score	0.143144 (rank : 1095)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1026	Shared Neighborhood Hits	327
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CI039_HUMAN
θ value	1.38821 (rank : 1302)	NC score	0.137042 (rank : 1152)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1171	Shared Neighborhood Hits	335
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

EZH1_HUMAN
θ value	1.38821 (rank : 1303)	NC score	0.001533 (rank : 2173)
Query Neighborhood Hits	1580	Target Neighborhood Hits	121	Shared Neighborhood Hits	14
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

HPLN2_HUMAN
θ value	1.38821 (rank : 1304)	NC score	0.007964 (rank : 2146)
Query Neighborhood Hits	1580	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q9GZV7	Gene names	HAPLN2, BRAL1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

KC1D_HUMAN
θ value	1.38821 (rank : 1305)	NC score	0.634249 (rank : 694)
Query Neighborhood Hits	1580	Target Neighborhood Hits	737	Shared Neighborhood Hits	711
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
θ value	1.38821 (rank : 1306)	NC score	0.634245 (rank : 695)
Query Neighborhood Hits	1580	Target Neighborhood Hits	737	Shared Neighborhood Hits	711
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1E_HUMAN
θ value	1.38821 (rank : 1307)	NC score	0.630716 (rank : 705)
Query Neighborhood Hits	1580	Target Neighborhood Hits	732	Shared Neighborhood Hits	711
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
θ value	1.38821 (rank : 1308)	NC score	0.630668 (rank : 706)
Query Neighborhood Hits	1580	Target Neighborhood Hits	728	Shared Neighborhood Hits	710
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

LRSM1_MOUSE
θ value	1.38821 (rank : 1309)	NC score	0.075444 (rank : 1655)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	276
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MAP1A_HUMAN
θ value	1.38821 (rank : 1310)	NC score	0.098845 (rank : 1452)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1626	Shared Neighborhood Hits	366
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NRG1_HUMAN
θ value	1.38821 (rank : 1311)	NC score	0.092248 (rank : 1506)
Query Neighborhood Hits	1580	Target Neighborhood Hits	285	Shared Neighborhood Hits	154
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

PARVB_HUMAN
θ value	1.38821 (rank : 1312)	NC score	0.025578 (rank : 2078)
Query Neighborhood Hits	1580	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HBI1, Q5TGJ5, Q86X93, Q9NSP7, Q9UGT3, Q9Y368, Q9Y3L6, Q9Y3L7	Gene names	PARVB
Domain Architecture
Description	Beta-parvin (Affixin).

PKHF1_MOUSE
θ value	1.38821 (rank : 1313)	NC score	0.065003 (rank : 1770)
Query Neighborhood Hits	1580	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PRGR_MOUSE
θ value	1.38821 (rank : 1314)	NC score	-0.005674 (rank : 2193)
Query Neighborhood Hits	1580	Target Neighborhood Hits	286	Shared Neighborhood Hits	31
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

PSG4_HUMAN
θ value	1.38821 (rank : 1315)	NC score	0.071935 (rank : 1697)
Query Neighborhood Hits	1580	Target Neighborhood Hits	243	Shared Neighborhood Hits	170
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

ROBO4_HUMAN
θ value	1.38821 (rank : 1316)	NC score	0.159857 (rank : 1003)
Query Neighborhood Hits	1580	Target Neighborhood Hits	364	Shared Neighborhood Hits	228
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

SIG12_HUMAN
θ value	1.38821 (rank : 1317)	NC score	0.075850 (rank : 1652)
Query Neighborhood Hits	1580	Target Neighborhood Hits	245	Shared Neighborhood Hits	186
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

TGON2_HUMAN
θ value	1.38821 (rank : 1318)	NC score	0.026185 (rank : 2074)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1037	Shared Neighborhood Hits	147
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

TP53B_MOUSE
θ value	1.38821 (rank : 1319)	NC score	0.021016 (rank : 2090)
Query Neighborhood Hits	1580	Target Neighborhood Hits	644	Shared Neighborhood Hits	105
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ZN692_HUMAN
θ value	1.38821 (rank : 1320)	NC score	-0.028192 (rank : 2213)
Query Neighborhood Hits	1580	Target Neighborhood Hits	808	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BU19, Q5SRA5, Q5SRA6, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97	Gene names	ZNF692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

AMPH_HUMAN
θ value	1.81305 (rank : 1321)	NC score	0.048675 (rank : 2028)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	135
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

CCD27_MOUSE
θ value	1.81305 (rank : 1322)	NC score	0.117844 (rank : 1311)
Query Neighborhood Hits	1580	Target Neighborhood Hits	461	Shared Neighborhood Hits	227
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CO4A2_MOUSE
θ value	1.81305 (rank : 1323)	NC score	-0.006574 (rank : 2196)
Query Neighborhood Hits	1580	Target Neighborhood Hits	492	Shared Neighborhood Hits	61
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CUTL1_MOUSE
θ value	1.81305 (rank : 1324)	NC score	0.107789 (rank : 1387)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1620	Shared Neighborhood Hits	370
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

ELOA1_HUMAN
θ value	1.81305 (rank : 1325)	NC score	0.009296 (rank : 2137)
Query Neighborhood Hits	1580	Target Neighborhood Hits	388	Shared Neighborhood Hits	46
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

FIP1_HUMAN
θ value	1.81305 (rank : 1326)	NC score	0.012146 (rank : 2119)
Query Neighborhood Hits	1580	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

GPA33_MOUSE
θ value	1.81305 (rank : 1327)	NC score	0.100689 (rank : 1437)
Query Neighborhood Hits	1580	Target Neighborhood Hits	294	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

IFT74_MOUSE
θ value	1.81305 (rank : 1328)	NC score	0.131773 (rank : 1197)
Query Neighborhood Hits	1580	Target Neighborhood Hits	939	Shared Neighborhood Hits	314
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IFT81_HUMAN
θ value	1.81305 (rank : 1329)	NC score	0.141301 (rank : 1117)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	323
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

JHD2B_MOUSE
θ value	1.81305 (rank : 1330)	NC score	0.000991 (rank : 2176)
Query Neighborhood Hits	1580	Target Neighborhood Hits	115	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

K2002_HUMAN
θ value	1.81305 (rank : 1331)	NC score	0.337161 (rank : 843)
Query Neighborhood Hits	1580	Target Neighborhood Hits	274	Shared Neighborhood Hits	261
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

LIPA2_MOUSE
θ value	1.81305 (rank : 1332)	NC score	0.117057 (rank : 1321)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1282	Shared Neighborhood Hits	342
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LIPB2_HUMAN
θ value	1.81305 (rank : 1333)	NC score	0.082828 (rank : 1591)
Query Neighborhood Hits	1580	Target Neighborhood Hits	599	Shared Neighborhood Hits	246
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

PC11X_HUMAN
θ value	1.81305 (rank : 1334)	NC score	-0.012087 (rank : 2201)
Query Neighborhood Hits	1580	Target Neighborhood Hits	199	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZA7, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5	Gene names	PCDH11X, PCDH11, PCDHX
Domain Architecture	No domain graphic available
Description	Protocadherin-11 X-linked precursor (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S).

PHC1_HUMAN
θ value	1.81305 (rank : 1335)	NC score	0.013509 (rank : 2113)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P78364, Q8WVM3, Q9BU63	Gene names	PHC1, EDR1, PH1
Domain Architecture
Description	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1).

PHLB2_HUMAN
θ value	1.81305 (rank : 1336)	NC score	0.110529 (rank : 1371)
Query Neighborhood Hits	1580	Target Neighborhood Hits	964	Shared Neighborhood Hits	324
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PPIP1_MOUSE
θ value	1.81305 (rank : 1337)	NC score	0.090155 (rank : 1517)
Query Neighborhood Hits	1580	Target Neighborhood Hits	377	Shared Neighborhood Hits	184
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PSG2_HUMAN
θ value	1.81305 (rank : 1338)	NC score	0.068833 (rank : 1731)
Query Neighborhood Hits	1580	Target Neighborhood Hits	229	Shared Neighborhood Hits	166
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

RIMB1_HUMAN
θ value	1.81305 (rank : 1339)	NC score	0.120866 (rank : 1282)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1479	Shared Neighborhood Hits	422
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

SNPC4_HUMAN
θ value	1.81305 (rank : 1340)	NC score	0.022898 (rank : 2086)
Query Neighborhood Hits	1580	Target Neighborhood Hits	589	Shared Neighborhood Hits	115
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SSBP4_HUMAN
θ value	1.81305 (rank : 1341)	NC score	0.001684 (rank : 2172)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

SYCC_MOUSE
θ value	1.81305 (rank : 1342)	NC score	0.010098 (rank : 2133)
Query Neighborhood Hits	1580	Target Neighborhood Hits	63	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ER72, O88303, Q8BP81, Q8CAY7, Q8CCE3, Q8K0S4, Q9ER68	Gene names	Cars
Domain Architecture
Description	Cysteinyl-tRNA synthetase, cytoplasmic (EC 6.1.1.16) (Cysteine--tRNA ligase) (CysRS).

TACC3_MOUSE
θ value	1.81305 (rank : 1343)	NC score	0.088896 (rank : 1526)
Query Neighborhood Hits	1580	Target Neighborhood Hits	607	Shared Neighborhood Hits	235
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

TRHY_HUMAN
θ value	1.81305 (rank : 1344)	NC score	0.144214 (rank : 1087)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1385	Shared Neighborhood Hits	342
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

TRI43_HUMAN
θ value	1.81305 (rank : 1345)	NC score	-0.003480 (rank : 2188)
Query Neighborhood Hits	1580	Target Neighborhood Hits	341	Shared Neighborhood Hits	77
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

ANR26_HUMAN
θ value	2.36792 (rank : 1346)	NC score	0.117030 (rank : 1322)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1614	Shared Neighborhood Hits	365
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

BT2A3_HUMAN
θ value	2.36792 (rank : 1347)	NC score	0.000387 (rank : 2179)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	45
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

CBX2_HUMAN
θ value	2.36792 (rank : 1348)	NC score	0.006334 (rank : 2154)
Query Neighborhood Hits	1580	Target Neighborhood Hits	264	Shared Neighborhood Hits	38
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

CHCH3_HUMAN
θ value	2.36792 (rank : 1349)	NC score	0.049347 (rank : 2027)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NX63	Gene names	CHCHD3
Domain Architecture	No domain graphic available
Description	Coiled-coil-helix-coiled-coil-helix domain-containing protein 3.

CO033_MOUSE
θ value	2.36792 (rank : 1350)	NC score	0.007147 (rank : 2151)
Query Neighborhood Hits	1580	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D518	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf33 homolog.

CUTL1_HUMAN
θ value	2.36792 (rank : 1351)	NC score	0.109226 (rank : 1381)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1574	Shared Neighborhood Hits	378
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

ES8L3_HUMAN
θ value	2.36792 (rank : 1352)	NC score	0.070449 (rank : 1711)
Query Neighborhood Hits	1580	Target Neighborhood Hits	206	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EZH1_MOUSE
θ value	2.36792 (rank : 1353)	NC score	0.001082 (rank : 2175)
Query Neighborhood Hits	1580	Target Neighborhood Hits	126	Shared Neighborhood Hits	14
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

HHLA2_HUMAN
θ value	2.36792 (rank : 1354)	NC score	0.049571 (rank : 2025)
Query Neighborhood Hits	1580	Target Neighborhood Hits	140	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

HIP1R_MOUSE
θ value	2.36792 (rank : 1355)	NC score	0.113223 (rank : 1352)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	319
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

ITPR1_HUMAN
θ value	2.36792 (rank : 1356)	NC score	0.002920 (rank : 2166)
Query Neighborhood Hits	1580	Target Neighborhood Hits	90	Shared Neighborhood Hits	32
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

JAD1D_MOUSE
θ value	2.36792 (rank : 1357)	NC score	0.005053 (rank : 2160)
Query Neighborhood Hits	1580	Target Neighborhood Hits	228	Shared Neighborhood Hits	65
SwissProt Accessions	Q62240, Q9QVR9, Q9R040	Gene names	Smcy, Hya, Jarid1d
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

JAM3_HUMAN
θ value	2.36792 (rank : 1358)	NC score	0.135772 (rank : 1164)
Query Neighborhood Hits	1580	Target Neighborhood Hits	271	Shared Neighborhood Hits	199
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

K0310_HUMAN
θ value	2.36792 (rank : 1359)	NC score	0.017998 (rank : 2098)
Query Neighborhood Hits	1580	Target Neighborhood Hits	420	Shared Neighborhood Hits	70
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

KC1G2_HUMAN
θ value	2.36792 (rank : 1360)	NC score	0.595083 (rank : 764)
Query Neighborhood Hits	1580	Target Neighborhood Hits	693	Shared Neighborhood Hits	677
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

MFAP3_MOUSE
θ value	2.36792 (rank : 1361)	NC score	0.052649 (rank : 1972)
Query Neighborhood Hits	1580	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

MILK1_MOUSE
θ value	2.36792 (rank : 1362)	NC score	0.076572 (rank : 1646)
Query Neighborhood Hits	1580	Target Neighborhood Hits	788	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MLKL_HUMAN
θ value	2.36792 (rank : 1363)	NC score	0.515600 (rank : 814)
Query Neighborhood Hits	1580	Target Neighborhood Hits	600	Shared Neighborhood Hits	576
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MLL2_HUMAN
θ value	2.36792 (rank : 1364)	NC score	0.041620 (rank : 2043)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1788	Shared Neighborhood Hits	322
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NRG2_MOUSE
θ value	2.36792 (rank : 1365)	NC score	0.119360 (rank : 1297)
Query Neighborhood Hits	1580	Target Neighborhood Hits	392	Shared Neighborhood Hits	209
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

RABE2_HUMAN
θ value	2.36792 (rank : 1366)	NC score	0.096959 (rank : 1463)
Query Neighborhood Hits	1580	Target Neighborhood Hits	545	Shared Neighborhood Hits	244
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

SAS6_MOUSE
θ value	2.36792 (rank : 1367)	NC score	0.123684 (rank : 1263)
Query Neighborhood Hits	1580	Target Neighborhood Hits	931	Shared Neighborhood Hits	313
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

SM1L2_HUMAN
θ value	2.36792 (rank : 1368)	NC score	0.123923 (rank : 1261)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1019	Shared Neighborhood Hits	323
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SVIL_MOUSE
θ value	2.36792 (rank : 1369)	NC score	0.016662 (rank : 2102)
Query Neighborhood Hits	1580	Target Neighborhood Hits	439	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TCOF_HUMAN
θ value	2.36792 (rank : 1370)	NC score	0.025479 (rank : 2079)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	111
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TF3B_MOUSE
θ value	2.36792 (rank : 1371)	NC score	0.006310 (rank : 2155)
Query Neighborhood Hits	1580	Target Neighborhood Hits	69	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CFK2	Gene names	Brf1
Domain Architecture	No domain graphic available
Description	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B- related factor 1) (BRF-1).

TMIGD_MOUSE
θ value	2.36792 (rank : 1372)	NC score	0.147331 (rank : 1065)
Query Neighborhood Hits	1580	Target Neighborhood Hits	234	Shared Neighborhood Hits	189
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

TXLNA_MOUSE
θ value	2.36792 (rank : 1373)	NC score	0.110893 (rank : 1368)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	300
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

ZN318_HUMAN
θ value	2.36792 (rank : 1374)	NC score	0.038286 (rank : 2049)
Query Neighborhood Hits	1580	Target Neighborhood Hits	497	Shared Neighborhood Hits	155
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

ZN438_HUMAN
θ value	2.36792 (rank : 1375)	NC score	-0.025867 (rank : 2209)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

AMGO1_HUMAN
θ value	3.0926 (rank : 1376)	NC score	0.043708 (rank : 2034)
Query Neighborhood Hits	1580	Target Neighborhood Hits	353	Shared Neighborhood Hits	96
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

AMGO3_MOUSE
θ value	3.0926 (rank : 1377)	NC score	0.040642 (rank : 2045)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

CABIN_HUMAN
θ value	3.0926 (rank : 1378)	NC score	0.018435 (rank : 2096)
Query Neighborhood Hits	1580	Target Neighborhood Hits	490	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CLMN_HUMAN
θ value	3.0926 (rank : 1379)	NC score	0.084630 (rank : 1566)
Query Neighborhood Hits	1580	Target Neighborhood Hits	205	Shared Neighborhood Hits	50
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

COQ6_MOUSE
θ value	3.0926 (rank : 1380)	NC score	0.004084 (rank : 2162)
Query Neighborhood Hits	1580	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R1S0	Gene names	Coq6
Domain Architecture
Description	Ubiquinone biosynthesis monooxygenase COQ6 (EC 1.14.13.-).

COVA1_MOUSE
θ value	3.0926 (rank : 1381)	NC score	0.074274 (rank : 1669)
Query Neighborhood Hits	1580	Target Neighborhood Hits	335	Shared Neighborhood Hits	157
SwissProt Accessions	Q8R0Z2, Q8BY59, Q8R372	Gene names	Cova1
Domain Architecture	No domain graphic available
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

CP135_HUMAN
θ value	3.0926 (rank : 1382)	NC score	0.141367 (rank : 1115)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1290	Shared Neighborhood Hits	347
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

CROCC_HUMAN
θ value	3.0926 (rank : 1383)	NC score	0.141782 (rank : 1110)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1409	Shared Neighborhood Hits	368
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

CTGE2_HUMAN
θ value	3.0926 (rank : 1384)	NC score	0.102781 (rank : 1421)
Query Neighborhood Hits	1580	Target Neighborhood Hits	594	Shared Neighborhood Hits	254
SwissProt Accessions	Q96RT6	Gene names	CTAGE1, CTAGE2
Domain Architecture	No domain graphic available
Description	Protein cTAGE-2.

DAAM1_HUMAN
θ value	3.0926 (rank : 1385)	NC score	0.042046 (rank : 2040)
Query Neighborhood Hits	1580	Target Neighborhood Hits	483	Shared Neighborhood Hits	204
SwissProt Accessions	Q9Y4D1, Q86U34, Q8N1Z8, Q8TB39	Gene names	DAAM1, KIAA0666
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

DAAM1_MOUSE
θ value	3.0926 (rank : 1386)	NC score	0.044805 (rank : 2032)
Query Neighborhood Hits	1580	Target Neighborhood Hits	443	Shared Neighborhood Hits	198
SwissProt Accessions	Q8BPM0, Q80Y68, Q9CQQ2	Gene names	Daam1
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

FA76B_MOUSE
θ value	3.0926 (rank : 1387)	NC score	0.027986 (rank : 2068)
Query Neighborhood Hits	1580	Target Neighborhood Hits	181	Shared Neighborhood Hits	95
SwissProt Accessions	Q80XP8, Q3UMA6, Q80YR1, Q8CI69	Gene names	Fam76b
Domain Architecture	No domain graphic available
Description	Protein FAM76B.

FBX34_MOUSE
θ value	3.0926 (rank : 1388)	NC score	0.006209 (rank : 2156)
Query Neighborhood Hits	1580	Target Neighborhood Hits	100	Shared Neighborhood Hits	19
SwissProt Accessions	Q80XI1, Q9D290	Gene names	Fbxo34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

FLIP1_MOUSE
θ value	3.0926 (rank : 1389)	NC score	0.138038 (rank : 1143)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1176	Shared Neighborhood Hits	346
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FOXP2_HUMAN
θ value	3.0926 (rank : 1390)	NC score	0.022700 (rank : 2087)
Query Neighborhood Hits	1580	Target Neighborhood Hits	366	Shared Neighborhood Hits	146
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

GPA33_HUMAN
θ value	3.0926 (rank : 1391)	NC score	0.095456 (rank : 1480)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	163
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

KIRR3_HUMAN
θ value	3.0926 (rank : 1392)	NC score	0.129632 (rank : 1212)
Query Neighborhood Hits	1580	Target Neighborhood Hits	302	Shared Neighborhood Hits	194
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

KIRR3_MOUSE
θ value	3.0926 (rank : 1393)	NC score	0.129414 (rank : 1214)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

LETM1_HUMAN
θ value	3.0926 (rank : 1394)	NC score	0.081736 (rank : 1606)
Query Neighborhood Hits	1580	Target Neighborhood Hits	338	Shared Neighborhood Hits	184
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

LV1C_MOUSE
θ value	3.0926 (rank : 1395)	NC score	-0.014031 (rank : 2204)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	P01725	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda-1 chain V region S178.

MTSS1_MOUSE
θ value	3.0926 (rank : 1396)	NC score	0.019127 (rank : 2094)
Query Neighborhood Hits	1580	Target Neighborhood Hits	592	Shared Neighborhood Hits	101
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

PGFRL_HUMAN
θ value	3.0926 (rank : 1397)	NC score	0.083924 (rank : 1578)
Query Neighborhood Hits	1580	Target Neighborhood Hits	115	Shared Neighborhood Hits	106
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

PHC1_MOUSE
θ value	3.0926 (rank : 1398)	NC score	0.013922 (rank : 2111)
Query Neighborhood Hits	1580	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

PKHF1_HUMAN
θ value	3.0926 (rank : 1399)	NC score	0.064957 (rank : 1771)
Query Neighborhood Hits	1580	Target Neighborhood Hits	76	Shared Neighborhood Hits	28
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PSG11_HUMAN
θ value	3.0926 (rank : 1400)	NC score	0.069324 (rank : 1722)
Query Neighborhood Hits	1580	Target Neighborhood Hits	223	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

PSG5_HUMAN
θ value	3.0926 (rank : 1401)	NC score	0.063788 (rank : 1785)
Query Neighborhood Hits	1580	Target Neighborhood Hits	231	Shared Neighborhood Hits	161
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

PSG8_HUMAN
θ value	3.0926 (rank : 1402)	NC score	0.073249 (rank : 1682)
Query Neighborhood Hits	1580	Target Neighborhood Hits	239	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

RAGE_HUMAN
θ value	3.0926 (rank : 1403)	NC score	0.143771 (rank : 1093)
Query Neighborhood Hits	1580	Target Neighborhood Hits	269	Shared Neighborhood Hits	201
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

REPS1_MOUSE
θ value	3.0926 (rank : 1404)	NC score	0.022196 (rank : 2089)
Query Neighborhood Hits	1580	Target Neighborhood Hits	204	Shared Neighborhood Hits	52
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

RUFY2_HUMAN
θ value	3.0926 (rank : 1405)	NC score	0.125761 (rank : 1247)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1208	Shared Neighborhood Hits	342
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

SALL2_HUMAN
θ value	3.0926 (rank : 1406)	NC score	-0.027111 (rank : 2210)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y467, Q9Y4G1	Gene names	SALL2, KIAA0360, SAL2
Domain Architecture	No domain graphic available
Description	Sal-like protein 2 (Zinc finger protein SALL2) (HSal2).

SYN3_HUMAN
θ value	3.0926 (rank : 1407)	NC score	0.008387 (rank : 2143)
Query Neighborhood Hits	1580	Target Neighborhood Hits	203	Shared Neighborhood Hits	41
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

TEX14_HUMAN
θ value	3.0926 (rank : 1408)	NC score	0.422265 (rank : 830)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1103	Shared Neighborhood Hits	634
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	3.0926 (rank : 1409)	NC score	0.477037 (rank : 818)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1333	Shared Neighborhood Hits	780
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TLE3_HUMAN
θ value	3.0926 (rank : 1410)	NC score	-0.008411 (rank : 2200)
Query Neighborhood Hits	1580	Target Neighborhood Hits	385	Shared Neighborhood Hits	36
SwissProt Accessions	Q04726, Q8IVV6, Q8WVR2, Q9HCM5	Gene names	TLE3, KIAA1547
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG3).

TRAF2_HUMAN
θ value	3.0926 (rank : 1411)	NC score	0.000033 (rank : 2180)
Query Neighborhood Hits	1580	Target Neighborhood Hits	402	Shared Neighborhood Hits	54
SwissProt Accessions	Q12933, Q96NT2	Gene names	TRAF2, TRAP3
Domain Architecture
Description	TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3).

TRI30_MOUSE
θ value	3.0926 (rank : 1412)	NC score	0.001852 (rank : 2169)
Query Neighborhood Hits	1580	Target Neighborhood Hits	434	Shared Neighborhood Hits	118
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TRI63_HUMAN
θ value	3.0926 (rank : 1413)	NC score	0.007562 (rank : 2150)
Query Neighborhood Hits	1580	Target Neighborhood Hits	298	Shared Neighborhood Hits	86
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

ZBT16_HUMAN
θ value	3.0926 (rank : 1414)	NC score	-0.030559 (rank : 2219)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1010	Shared Neighborhood Hits	37
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).

AINX_HUMAN
θ value	4.03905 (rank : 1415)	NC score	0.032835 (rank : 2059)
Query Neighborhood Hits	1580	Target Neighborhood Hits	442	Shared Neighborhood Hits	208
SwissProt Accessions	Q16352, Q9BRC5	Gene names	INA
Domain Architecture
Description	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (Neurofilament-66) (NF-66).

AL2S2_HUMAN
θ value	4.03905 (rank : 1416)	NC score	0.713835 (rank : 577)
Query Neighborhood Hits	1580	Target Neighborhood Hits	727	Shared Neighborhood Hits	705
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

AMPH_MOUSE
θ value	4.03905 (rank : 1417)	NC score	0.049487 (rank : 2026)
Query Neighborhood Hits	1580	Target Neighborhood Hits	291	Shared Neighborhood Hits	112
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

ARNT_MOUSE
θ value	4.03905 (rank : 1418)	NC score	-0.000283 (rank : 2181)
Query Neighborhood Hits	1580	Target Neighborhood Hits	213	Shared Neighborhood Hits	26
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

BRE1B_HUMAN
θ value	4.03905 (rank : 1419)	NC score	0.118596 (rank : 1305)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1040	Shared Neighborhood Hits	315
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	4.03905 (rank : 1420)	NC score	0.117350 (rank : 1316)
Query Neighborhood Hits	1580	Target Neighborhood Hits	970	Shared Neighborhood Hits	302
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

BT1A1_HUMAN
θ value	4.03905 (rank : 1421)	NC score	0.012036 (rank : 2120)
Query Neighborhood Hits	1580	Target Neighborhood Hits	322	Shared Neighborhood Hits	98
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

CCD13_HUMAN
θ value	4.03905 (rank : 1422)	NC score	0.126536 (rank : 1242)
Query Neighborhood Hits	1580	Target Neighborhood Hits	721	Shared Neighborhood Hits	279
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

CD276_HUMAN
θ value	4.03905 (rank : 1423)	NC score	0.065916 (rank : 1762)
Query Neighborhood Hits	1580	Target Neighborhood Hits	261	Shared Neighborhood Hits	129
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

CI093_HUMAN
θ value	4.03905 (rank : 1424)	NC score	0.144751 (rank : 1082)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1088	Shared Neighborhood Hits	345
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CYLN2_HUMAN
θ value	4.03905 (rank : 1425)	NC score	0.132793 (rank : 1186)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1004	Shared Neighborhood Hits	317
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

DTBP1_MOUSE
θ value	4.03905 (rank : 1426)	NC score	0.060419 (rank : 1838)
Query Neighborhood Hits	1580	Target Neighborhood Hits	209	Shared Neighborhood Hits	127
SwissProt Accessions	Q91WZ8, Q80ZN4	Gene names	Dtnbp1
Domain Architecture
Description	Dystrobrevin-binding protein 1 (Dysbindin) (Hermansky-Pudlak syndrome 7 protein homolog).

EVPL_MOUSE
θ value	4.03905 (rank : 1427)	NC score	0.135112 (rank : 1166)
Query Neighborhood Hits	1580	Target Neighborhood Hits	952	Shared Neighborhood Hits	304
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

FLNB_MOUSE
θ value	4.03905 (rank : 1428)	NC score	0.058465 (rank : 1873)
Query Neighborhood Hits	1580	Target Neighborhood Hits	126	Shared Neighborhood Hits	41
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

GRAP2_HUMAN
θ value	4.03905 (rank : 1429)	NC score	0.123109 (rank : 1266)
Query Neighborhood Hits	1580	Target Neighborhood Hits	304	Shared Neighborhood Hits	106
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_MOUSE
θ value	4.03905 (rank : 1430)	NC score	0.131712 (rank : 1199)
Query Neighborhood Hits	1580	Target Neighborhood Hits	309	Shared Neighborhood Hits	106
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

HN1L_HUMAN
θ value	4.03905 (rank : 1431)	NC score	0.008728 (rank : 2141)
Query Neighborhood Hits	1580	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

ILRL2_MOUSE
θ value	4.03905 (rank : 1432)	NC score	0.050010 (rank : 2022)
Query Neighborhood Hits	1580	Target Neighborhood Hits	158	Shared Neighborhood Hits	123
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

LRSM1_HUMAN
θ value	4.03905 (rank : 1433)	NC score	0.085798 (rank : 1555)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1078	Shared Neighborhood Hits	315
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MAVS_MOUSE
θ value	4.03905 (rank : 1434)	NC score	0.011084 (rank : 2125)
Query Neighborhood Hits	1580	Target Neighborhood Hits	170	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

NKTR_MOUSE
θ value	4.03905 (rank : 1435)	NC score	-0.000619 (rank : 2182)
Query Neighborhood Hits	1580	Target Neighborhood Hits	417	Shared Neighborhood Hits	54
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

RTN4_HUMAN
θ value	4.03905 (rank : 1436)	NC score	0.015788 (rank : 2106)
Query Neighborhood Hits	1580	Target Neighborhood Hits	357	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SYRM_MOUSE
θ value	4.03905 (rank : 1437)	NC score	0.002223 (rank : 2168)
Query Neighborhood Hits	1580	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U186, Q8QZU7	Gene names	Rarsl, Rars2
Domain Architecture	No domain graphic available
Description	Probable arginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.19) (Arginine--tRNA ligase) (ArgRS) (Arginyl-tRNA synthetase-like).

T240L_HUMAN
θ value	4.03905 (rank : 1438)	NC score	0.003562 (rank : 2163)
Query Neighborhood Hits	1580	Target Neighborhood Hits	132	Shared Neighborhood Hits	22
SwissProt Accessions	Q71F56, Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5	Gene names	THRAP2, KIAA1025, PROSIT240, TRAP240L
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

TENS4_MOUSE
θ value	4.03905 (rank : 1439)	NC score	0.033216 (rank : 2057)
Query Neighborhood Hits	1580	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX9_MOUSE
θ value	4.03905 (rank : 1440)	NC score	0.103634 (rank : 1416)
Query Neighborhood Hits	1580	Target Neighborhood Hits	581	Shared Neighborhood Hits	243
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

ZN335_HUMAN
θ value	4.03905 (rank : 1441)	NC score	-0.027250 (rank : 2211)
Query Neighborhood Hits	1580	Target Neighborhood Hits	973	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

ASPP1_MOUSE
θ value	5.27518 (rank : 1442)	NC score	0.086074 (rank : 1553)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1244	Shared Neighborhood Hits	353
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BAZ1A_HUMAN
θ value	5.27518 (rank : 1443)	NC score	0.042011 (rank : 2041)
Query Neighborhood Hits	1580	Target Neighborhood Hits	693	Shared Neighborhood Hits	226
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

BMR1A_HUMAN
θ value	5.27518 (rank : 1444)	NC score	0.593852 (rank : 766)
Query Neighborhood Hits	1580	Target Neighborhood Hits	759	Shared Neighborhood Hits	731
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

BMR1A_MOUSE
θ value	5.27518 (rank : 1445)	NC score	0.592876 (rank : 769)
Query Neighborhood Hits	1580	Target Neighborhood Hits	758	Shared Neighborhood Hits	732
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

CAC1H_MOUSE
θ value	5.27518 (rank : 1446)	NC score	-0.002270 (rank : 2183)
Query Neighborhood Hits	1580	Target Neighborhood Hits	230	Shared Neighborhood Hits	32
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CDT1_MOUSE
θ value	5.27518 (rank : 1447)	NC score	0.009985 (rank : 2134)
Query Neighborhood Hits	1580	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

CO9A1_MOUSE
θ value	5.27518 (rank : 1448)	NC score	-0.008293 (rank : 2199)
Query Neighborhood Hits	1580	Target Neighborhood Hits	477	Shared Neighborhood Hits	43
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

DHX8_HUMAN
θ value	5.27518 (rank : 1449)	NC score	-0.002795 (rank : 2186)
Query Neighborhood Hits	1580	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	Q14562	Gene names	DHX8, DDX8
Domain Architecture
Description	ATP-dependent RNA helicase DHX8 (EC 3.6.1.-) (DEAH box protein 8) (RNA helicase HRH1).

ES8L1_HUMAN
θ value	5.27518 (rank : 1450)	NC score	0.056681 (rank : 1903)
Query Neighborhood Hits	1580	Target Neighborhood Hits	162	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FMN2_HUMAN
θ value	5.27518 (rank : 1451)	NC score	0.022253 (rank : 2088)
Query Neighborhood Hits	1580	Target Neighborhood Hits	484	Shared Neighborhood Hits	130
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

FOXP2_MOUSE
θ value	5.27518 (rank : 1452)	NC score	0.023531 (rank : 2083)
Query Neighborhood Hits	1580	Target Neighborhood Hits	366	Shared Neighborhood Hits	149
SwissProt Accessions	P58463, Q6PD37, Q8C4F0, Q8R441	Gene names	Foxp2
Domain Architecture
Description	Forkhead box protein P2.

GORS2_MOUSE
θ value	5.27518 (rank : 1453)	NC score	0.005210 (rank : 2158)
Query Neighborhood Hits	1580	Target Neighborhood Hits	89	Shared Neighborhood Hits	19
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

IRS1_HUMAN
θ value	5.27518 (rank : 1454)	NC score	0.005152 (rank : 2159)
Query Neighborhood Hits	1580	Target Neighborhood Hits	109	Shared Neighborhood Hits	21
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

JAM1_MOUSE
θ value	5.27518 (rank : 1455)	NC score	0.126438 (rank : 1243)
Query Neighborhood Hits	1580	Target Neighborhood Hits	287	Shared Neighborhood Hits	202
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

JARD2_MOUSE
θ value	5.27518 (rank : 1456)	NC score	0.000768 (rank : 2178)
Query Neighborhood Hits	1580	Target Neighborhood Hits	169	Shared Neighborhood Hits	27
SwissProt Accessions	Q62315, Q99LD1	Gene names	Jarid2, Jmj
Domain Architecture
Description	Jumonji protein (Jumonji/ARID domain-containing protein 2).

K0555_HUMAN
θ value	5.27518 (rank : 1457)	NC score	0.145251 (rank : 1079)
Query Neighborhood Hits	1580	Target Neighborhood Hits	880	Shared Neighborhood Hits	316
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

K2002_MOUSE
θ value	5.27518 (rank : 1458)	NC score	0.280025 (rank : 848)
Query Neighborhood Hits	1580	Target Neighborhood Hits	267	Shared Neighborhood Hits	235
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

KIF3A_MOUSE
θ value	5.27518 (rank : 1459)	NC score	0.055593 (rank : 1917)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	266
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

LETM1_MOUSE
θ value	5.27518 (rank : 1460)	NC score	0.065995 (rank : 1760)
Query Neighborhood Hits	1580	Target Neighborhood Hits	240	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Z2I0, Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5	Gene names	Letm1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

MAML3_HUMAN
θ value	5.27518 (rank : 1461)	NC score	0.012392 (rank : 2118)
Query Neighborhood Hits	1580	Target Neighborhood Hits	323	Shared Neighborhood Hits	66
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

MBB1A_HUMAN
θ value	5.27518 (rank : 1462)	NC score	0.023050 (rank : 2084)
Query Neighborhood Hits	1580	Target Neighborhood Hits	665	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

MYO10_HUMAN
θ value	5.27518 (rank : 1463)	NC score	0.088504 (rank : 1532)
Query Neighborhood Hits	1580	Target Neighborhood Hits	920	Shared Neighborhood Hits	289
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

NRBP_MOUSE
θ value	5.27518 (rank : 1464)	NC score	0.449235 (rank : 821)
Query Neighborhood Hits	1580	Target Neighborhood Hits	442	Shared Neighborhood Hits	410
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

PRGC2_HUMAN
θ value	5.27518 (rank : 1465)	NC score	0.007816 (rank : 2148)
Query Neighborhood Hits	1580	Target Neighborhood Hits	272	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

PSG3_HUMAN
θ value	5.27518 (rank : 1466)	NC score	0.072517 (rank : 1689)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	168
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

RMP_HUMAN
θ value	5.27518 (rank : 1467)	NC score	0.008940 (rank : 2140)
Query Neighborhood Hits	1580	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	O94763	Gene names	RMP, C19orf2
Domain Architecture
Description	RNA polymerase II subunit 5-mediating protein (RPB5-mediating protein).

RUSC2_HUMAN
θ value	5.27518 (rank : 1468)	NC score	0.023010 (rank : 2085)
Query Neighborhood Hits	1580	Target Neighborhood Hits	205	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SC6A5_MOUSE
θ value	5.27518 (rank : 1469)	NC score	-0.005319 (rank : 2192)
Query Neighborhood Hits	1580	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q761V0, Q8CFM5, Q91ZQ2	Gene names	Slc6a5, Glyt2
Domain Architecture	No domain graphic available
Description	Sodium- and chloride-dependent glycine transporter 2 (GlyT2) (GlyT-2) (Solute carrier family 6 member 5).

SON_HUMAN
θ value	5.27518 (rank : 1470)	NC score	0.027898 (rank : 2069)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1568	Shared Neighborhood Hits	208
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

TPM3_HUMAN
θ value	5.27518 (rank : 1471)	NC score	0.109735 (rank : 1378)
Query Neighborhood Hits	1580	Target Neighborhood Hits	689	Shared Neighborhood Hits	271
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

UN84A_MOUSE
θ value	5.27518 (rank : 1472)	NC score	0.016627 (rank : 2103)
Query Neighborhood Hits	1580	Target Neighborhood Hits	99	Shared Neighborhood Hits	52
SwissProt Accessions	Q9D666, Q80SU8, Q8BZ99, Q99P23	Gene names	Unc84a, Sun1
Domain Architecture	No domain graphic available
Description	Sad1/unc-84 protein-like 1 (Unc-84 homolog A).

URFB1_HUMAN
θ value	5.27518 (rank : 1473)	NC score	0.003371 (rank : 2164)
Query Neighborhood Hits	1580	Target Neighborhood Hits	67	Shared Neighborhood Hits	7
SwissProt Accessions	Q6BDS2, Q9NXE0	Gene names	UHRF1BP1, C6orf107
Domain Architecture	No domain graphic available
Description	UHRF1-binding protein 1 (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) (ICBP90-binding protein 1).

ZN667_HUMAN
θ value	5.27518 (rank : 1474)	NC score	-0.028574 (rank : 2215)
Query Neighborhood Hits	1580	Target Neighborhood Hits	773	Shared Neighborhood Hits	21
SwissProt Accessions	Q5HYK9, Q6B093, Q9H807	Gene names	ZNF667
Domain Architecture	No domain graphic available
Description	Zinc finger protein 667.

ABI1_MOUSE
θ value	6.88961 (rank : 1475)	NC score	0.053553 (rank : 1955)
Query Neighborhood Hits	1580	Target Neighborhood Hits	246	Shared Neighborhood Hits	94
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	6.88961 (rank : 1476)	NC score	0.062296 (rank : 1806)
Query Neighborhood Hits	1580	Target Neighborhood Hits	350	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ANK2_HUMAN
θ value	6.88961 (rank : 1477)	NC score	0.025048 (rank : 2081)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1615	Shared Neighborhood Hits	241
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANS4B_HUMAN
θ value	6.88961 (rank : 1478)	NC score	0.001813 (rank : 2170)
Query Neighborhood Hits	1580	Target Neighborhood Hits	289	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ASXL1_HUMAN
θ value	6.88961 (rank : 1479)	NC score	0.009878 (rank : 2135)
Query Neighborhood Hits	1580	Target Neighborhood Hits	260	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

CD166_MOUSE
θ value	6.88961 (rank : 1480)	NC score	0.096897 (rank : 1466)
Query Neighborhood Hits	1580	Target Neighborhood Hits	252	Shared Neighborhood Hits	165
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

CEAM5_HUMAN
θ value	6.88961 (rank : 1481)	NC score	0.114582 (rank : 1340)
Query Neighborhood Hits	1580	Target Neighborhood Hits	343	Shared Neighborhood Hits	211
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

CNTRB_MOUSE
θ value	6.88961 (rank : 1482)	NC score	0.127621 (rank : 1230)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1029	Shared Neighborhood Hits	315
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CPT1A_MOUSE
θ value	6.88961 (rank : 1483)	NC score	-0.002590 (rank : 2185)
Query Neighborhood Hits	1580	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P97742, O35288, Q80SW3, Q8BP98, Q8C7H8	Gene names	Cpt1a, Cpt-1, Cpt1
Domain Architecture
Description	Carnitine O-palmitoyltransferase I, liver isoform (EC 2.3.1.21) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A).

DDX24_MOUSE
θ value	6.88961 (rank : 1484)	NC score	-0.006150 (rank : 2194)
Query Neighborhood Hits	1580	Target Neighborhood Hits	147	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

ES8L3_MOUSE
θ value	6.88961 (rank : 1485)	NC score	0.060328 (rank : 1840)
Query Neighborhood Hits	1580	Target Neighborhood Hits	168	Shared Neighborhood Hits	84
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FA76B_HUMAN
θ value	6.88961 (rank : 1486)	NC score	0.029675 (rank : 2064)
Query Neighborhood Hits	1580	Target Neighborhood Hits	184	Shared Neighborhood Hits	97
SwissProt Accessions	Q5HYJ3, Q6PIU3, Q8TC53	Gene names	FAM76B
Domain Architecture	No domain graphic available
Description	Protein FAM76B.

FIP1_MOUSE
θ value	6.88961 (rank : 1487)	NC score	0.007947 (rank : 2147)
Query Neighborhood Hits	1580	Target Neighborhood Hits	120	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D824, Q8BWX7, Q99LH0, Q9DBB2	Gene names	Fip1l1
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1).

HPLN2_MOUSE
θ value	6.88961 (rank : 1488)	NC score	0.010547 (rank : 2128)
Query Neighborhood Hits	1580	Target Neighborhood Hits	102	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ESM3	Gene names	Hapln2, Bral1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

HPLN4_HUMAN
θ value	6.88961 (rank : 1489)	NC score	0.006609 (rank : 2152)
Query Neighborhood Hits	1580	Target Neighborhood Hits	100	Shared Neighborhood Hits	49
SwissProt Accessions	Q86UW8, Q96PW2	Gene names	HAPLN4, BRAL2, KIAA1926
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2).

IF39_MOUSE
θ value	6.88961 (rank : 1490)	NC score	0.010677 (rank : 2127)
Query Neighborhood Hits	1580	Target Neighborhood Hits	206	Shared Neighborhood Hits	37
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

JAM1_HUMAN
θ value	6.88961 (rank : 1491)	NC score	0.131899 (rank : 1194)
Query Neighborhood Hits	1580	Target Neighborhood Hits	294	Shared Neighborhood Hits	204
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

KCNQ2_MOUSE
θ value	6.88961 (rank : 1492)	NC score	-0.004875 (rank : 2191)
Query Neighborhood Hits	1580	Target Neighborhood Hits	163	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

LEUK_HUMAN
θ value	6.88961 (rank : 1493)	NC score	0.013869 (rank : 2112)
Query Neighborhood Hits	1580	Target Neighborhood Hits	213	Shared Neighborhood Hits	40
SwissProt Accessions	P16150	Gene names	SPN, CD43
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Galactoglycoprotein) (GALGP) (CD43 antigen).

LV1E_HUMAN
θ value	6.88961 (rank : 1494)	NC score	-0.013612 (rank : 2202)
Query Neighborhood Hits	1580	Target Neighborhood Hits	238	Shared Neighborhood Hits	11
SwissProt Accessions	P01703	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region NEWM.

MUC13_MOUSE
θ value	6.88961 (rank : 1495)	NC score	0.018372 (rank : 2097)
Query Neighborhood Hits	1580	Target Neighborhood Hits	447	Shared Neighborhood Hits	77
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

MUCDL_MOUSE
θ value	6.88961 (rank : 1496)	NC score	0.002971 (rank : 2165)
Query Neighborhood Hits	1580	Target Neighborhood Hits	461	Shared Neighborhood Hits	67
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

MYCB2_HUMAN
θ value	6.88961 (rank : 1497)	NC score	0.013358 (rank : 2114)
Query Neighborhood Hits	1580	Target Neighborhood Hits	390	Shared Neighborhood Hits	53
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

MYO15_HUMAN
θ value	6.88961 (rank : 1498)	NC score	0.057740 (rank : 1882)
Query Neighborhood Hits	1580	Target Neighborhood Hits	671	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

NCOR1_HUMAN
θ value	6.88961 (rank : 1499)	NC score	0.019139 (rank : 2093)
Query Neighborhood Hits	1580	Target Neighborhood Hits	577	Shared Neighborhood Hits	133
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

NRBP_HUMAN
θ value	6.88961 (rank : 1500)	NC score	0.451435 (rank : 819)
Query Neighborhood Hits	1580	Target Neighborhood Hits	448	Shared Neighborhood Hits	414
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

OFD1_HUMAN
θ value	6.88961 (rank : 1501)	NC score	0.125947 (rank : 1246)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	280
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

PCLO_HUMAN
θ value	6.88961 (rank : 1502)	NC score	0.058077 (rank : 1877)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2046	Shared Neighborhood Hits	380
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PCLO_MOUSE
θ value	6.88961 (rank : 1503)	NC score	0.052541 (rank : 1975)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2275	Shared Neighborhood Hits	372
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PCX3_MOUSE
θ value	6.88961 (rank : 1504)	NC score	0.008948 (rank : 2139)
Query Neighborhood Hits	1580	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

PECA1_HUMAN
θ value	6.88961 (rank : 1505)	NC score	0.065372 (rank : 1767)
Query Neighborhood Hits	1580	Target Neighborhood Hits	178	Shared Neighborhood Hits	123
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

PLCB1_HUMAN
θ value	6.88961 (rank : 1506)	NC score	0.059694 (rank : 1850)
Query Neighborhood Hits	1580	Target Neighborhood Hits	614	Shared Neighborhood Hits	227
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PSG7_HUMAN
θ value	6.88961 (rank : 1507)	NC score	0.069300 (rank : 1724)
Query Neighborhood Hits	1580	Target Neighborhood Hits	239	Shared Neighborhood Hits	167
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

RFIP5_MOUSE
θ value	6.88961 (rank : 1508)	NC score	0.001686 (rank : 2171)
Query Neighborhood Hits	1580	Target Neighborhood Hits	126	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

RGS3_HUMAN
θ value	6.88961 (rank : 1509)	NC score	0.033068 (rank : 2058)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1375	Shared Neighborhood Hits	179
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RNF8_HUMAN
θ value	6.88961 (rank : 1510)	NC score	0.053534 (rank : 1956)
Query Neighborhood Hits	1580	Target Neighborhood Hits	622	Shared Neighborhood Hits	198
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

RPGR1_MOUSE
θ value	6.88961 (rank : 1511)	NC score	0.083563 (rank : 1582)
Query Neighborhood Hits	1580	Target Neighborhood Hits	713	Shared Neighborhood Hits	245
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

SHLB1_MOUSE
θ value	6.88961 (rank : 1512)	NC score	0.014892 (rank : 2107)
Query Neighborhood Hits	1580	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SIGIR_MOUSE
θ value	6.88961 (rank : 1513)	NC score	0.023602 (rank : 2082)
Query Neighborhood Hits	1580	Target Neighborhood Hits	95	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

SIGL8_HUMAN
θ value	6.88961 (rank : 1514)	NC score	0.080803 (rank : 1611)
Query Neighborhood Hits	1580	Target Neighborhood Hits	252	Shared Neighborhood Hits	188
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

SMC2_HUMAN
θ value	6.88961 (rank : 1515)	NC score	0.119292 (rank : 1298)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1405	Shared Neighborhood Hits	349
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

SWP70_MOUSE
θ value	6.88961 (rank : 1516)	NC score	0.130680 (rank : 1203)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1097	Shared Neighborhood Hits	342
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TPR_HUMAN
θ value	6.88961 (rank : 1517)	NC score	0.141193 (rank : 1119)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1921	Shared Neighborhood Hits	413
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

TSC1_HUMAN
θ value	6.88961 (rank : 1518)	NC score	0.127474 (rank : 1234)
Query Neighborhood Hits	1580	Target Neighborhood Hits	765	Shared Neighborhood Hits	289
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

TYRO3_MOUSE
θ value	6.88961 (rank : 1519)	NC score	0.632308 (rank : 699)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1007	Shared Neighborhood Hits	899
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

ZBTB3_HUMAN
θ value	6.88961 (rank : 1520)	NC score	-0.028759 (rank : 2216)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H5J0	Gene names	ZBTB3
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 3.

ZCPW1_MOUSE
θ value	6.88961 (rank : 1521)	NC score	0.009052 (rank : 2138)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	57
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

ZN679_HUMAN
θ value	6.88961 (rank : 1522)	NC score	-0.028913 (rank : 2217)
Query Neighborhood Hits	1580	Target Neighborhood Hits	746	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IYX0	Gene names	ZNF679
Domain Architecture	No domain graphic available
Description	Zinc finger protein 679.

AMGO3_HUMAN
θ value	8.99809 (rank : 1523)	NC score	0.040389 (rank : 2046)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	82
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

BUB1B_HUMAN
θ value	8.99809 (rank : 1524)	NC score	0.117563 (rank : 1314)
Query Neighborhood Hits	1580	Target Neighborhood Hits	208	Shared Neighborhood Hits	148
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

CCD21_HUMAN
θ value	8.99809 (rank : 1525)	NC score	0.122044 (rank : 1272)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1228	Shared Neighborhood Hits	345
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	8.99809 (rank : 1526)	NC score	0.129184 (rank : 1216)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1135	Shared Neighborhood Hits	343
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD71_HUMAN
θ value	8.99809 (rank : 1527)	NC score	0.004682 (rank : 2161)
Query Neighborhood Hits	1580	Target Neighborhood Hits	55	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IV32, Q6IPE2, Q9H8H4, Q9H9F1	Gene names	CCDC71
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 71.

CCD91_HUMAN
θ value	8.99809 (rank : 1528)	NC score	0.120219 (rank : 1289)
Query Neighborhood Hits	1580	Target Neighborhood Hits	868	Shared Neighborhood Hits	289
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CD276_MOUSE
θ value	8.99809 (rank : 1529)	NC score	0.049809 (rank : 2024)
Query Neighborhood Hits	1580	Target Neighborhood Hits	243	Shared Neighborhood Hits	134
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

CD2AP_MOUSE
θ value	8.99809 (rank : 1530)	NC score	0.078995 (rank : 1621)
Query Neighborhood Hits	1580	Target Neighborhood Hits	336	Shared Neighborhood Hits	130
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CDR2_MOUSE
θ value	8.99809 (rank : 1531)	NC score	0.106459 (rank : 1399)
Query Neighborhood Hits	1580	Target Neighborhood Hits	482	Shared Neighborhood Hits	240
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

CMC2_MOUSE
θ value	8.99809 (rank : 1532)	NC score	-0.006836 (rank : 2197)
Query Neighborhood Hits	1580	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXX4, Q9CZF6, Q9DCF5	Gene names	Slc25a13, Aralar2
Domain Architecture
Description	Calcium-binding mitochondrial carrier protein Aralar2 (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13) (Citrin).

CR034_MOUSE
θ value	8.99809 (rank : 1533)	NC score	0.128680 (rank : 1217)
Query Neighborhood Hits	1580	Target Neighborhood Hits	643	Shared Neighborhood Hits	274
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

DSCR6_HUMAN
θ value	8.99809 (rank : 1534)	NC score	0.006601 (rank : 2153)
Query Neighborhood Hits	1580	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	P57055	Gene names	DSCR6, RIPPLY3
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 6.

EP15_HUMAN
θ value	8.99809 (rank : 1535)	NC score	0.106096 (rank : 1401)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1021	Shared Neighborhood Hits	322
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EPS8_HUMAN
θ value	8.99809 (rank : 1536)	NC score	0.040211 (rank : 2048)
Query Neighborhood Hits	1580	Target Neighborhood Hits	151	Shared Neighborhood Hits	71
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	8.99809 (rank : 1537)	NC score	0.042432 (rank : 2038)
Query Neighborhood Hits	1580	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EVPL_HUMAN
θ value	8.99809 (rank : 1538)	NC score	0.136741 (rank : 1155)
Query Neighborhood Hits	1580	Target Neighborhood Hits	895	Shared Neighborhood Hits	312
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

GOG8A_HUMAN
θ value	8.99809 (rank : 1539)	NC score	0.121600 (rank : 1275)
Query Neighborhood Hits	1580	Target Neighborhood Hits	635	Shared Neighborhood Hits	267
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

GPTC8_HUMAN
θ value	8.99809 (rank : 1540)	NC score	0.011536 (rank : 2121)
Query Neighborhood Hits	1580	Target Neighborhood Hits	366	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

GRIN1_MOUSE
θ value	8.99809 (rank : 1541)	NC score	0.016947 (rank : 2101)
Query Neighborhood Hits	1580	Target Neighborhood Hits	337	Shared Neighborhood Hits	69
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

HXD3_MOUSE
θ value	8.99809 (rank : 1542)	NC score	-0.017185 (rank : 2206)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	26
SwissProt Accessions	P09027, Q3UUD3	Gene names	Hoxd3, Hox-4.1, Hoxd-3
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4.1) (Homeobox protein MH-19).

IQEC1_HUMAN
θ value	8.99809 (rank : 1543)	NC score	-0.002301 (rank : 2184)
Query Neighborhood Hits	1580	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

IRS1_MOUSE
θ value	8.99809 (rank : 1544)	NC score	0.008437 (rank : 2142)
Query Neighborhood Hits	1580	Target Neighborhood Hits	112	Shared Neighborhood Hits	26
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

KCNH6_HUMAN
θ value	8.99809 (rank : 1545)	NC score	0.000770 (rank : 2177)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

LV2A_MOUSE
θ value	8.99809 (rank : 1546)	NC score	-0.014115 (rank : 2205)
Query Neighborhood Hits	1580	Target Neighborhood Hits	217	Shared Neighborhood Hits	4
SwissProt Accessions	P01728	Gene names
Domain Architecture
Description	Ig lambda-2 chain V region precursor.

MDC1_HUMAN
θ value	8.99809 (rank : 1547)	NC score	0.037684 (rank : 2050)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1446	Shared Neighborhood Hits	233
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MORC3_HUMAN
θ value	8.99809 (rank : 1548)	NC score	0.086873 (rank : 1547)
Query Neighborhood Hits	1580	Target Neighborhood Hits	489	Shared Neighborhood Hits	237
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

MOX2R_MOUSE
θ value	8.99809 (rank : 1549)	NC score	0.061225 (rank : 1826)
Query Neighborhood Hits	1580	Target Neighborhood Hits	110	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

NFL_HUMAN
θ value	8.99809 (rank : 1550)	NC score	0.043677 (rank : 2036)
Query Neighborhood Hits	1580	Target Neighborhood Hits	666	Shared Neighborhood Hits	246
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

NRG2_HUMAN
θ value	8.99809 (rank : 1551)	NC score	0.121255 (rank : 1281)
Query Neighborhood Hits	1580	Target Neighborhood Hits	419	Shared Neighborhood Hits	219
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

PEX13_HUMAN
θ value	8.99809 (rank : 1552)	NC score	0.044364 (rank : 2033)
Query Neighborhood Hits	1580	Target Neighborhood Hits	128	Shared Neighborhood Hits	62
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PHF12_MOUSE
θ value	8.99809 (rank : 1553)	NC score	-0.004316 (rank : 2189)
Query Neighborhood Hits	1580	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

PHLB2_MOUSE
θ value	8.99809 (rank : 1554)	NC score	0.112190 (rank : 1357)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1016	Shared Neighborhood Hits	331
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

PHX2A_HUMAN
θ value	8.99809 (rank : 1555)	NC score	-0.018227 (rank : 2208)
Query Neighborhood Hits	1580	Target Neighborhood Hits	345	Shared Neighborhood Hits	9
SwissProt Accessions	O14813, Q8IVZ2	Gene names	PHOX2A, ARIX, PMX2A
Domain Architecture
Description	Paired mesoderm homeobox protein 2A (Paired-like homeobox 2A) (Aristaless homeobox protein homolog) (ARIX1 homeodomain protein).

PKD2_MOUSE
θ value	8.99809 (rank : 1556)	NC score	-0.002898 (rank : 2187)
Query Neighborhood Hits	1580	Target Neighborhood Hits	99	Shared Neighborhood Hits	11
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PLCB1_MOUSE
θ value	8.99809 (rank : 1557)	NC score	0.056034 (rank : 1913)
Query Neighborhood Hits	1580	Target Neighborhood Hits	531	Shared Neighborhood Hits	216
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PSL1_HUMAN
θ value	8.99809 (rank : 1558)	NC score	0.011451 (rank : 2124)
Query Neighborhood Hits	1580	Target Neighborhood Hits	650	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RHG25_MOUSE
θ value	8.99809 (rank : 1559)	NC score	0.035319 (rank : 2053)
Query Neighborhood Hits	1580	Target Neighborhood Hits	492	Shared Neighborhood Hits	166
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RINT1_MOUSE
θ value	8.99809 (rank : 1560)	NC score	0.014717 (rank : 2108)
Query Neighborhood Hits	1580	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BZ36, Q3UXS1, Q6P1I2, Q8C193	Gene names	Rint1
Domain Architecture	No domain graphic available
Description	RAD50-interacting protein 1 (RAD50 interactor 1) (Protein RINT-1).

SAS10_HUMAN
θ value	8.99809 (rank : 1561)	NC score	0.010264 (rank : 2132)
Query Neighborhood Hits	1580	Target Neighborhood Hits	102	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NQZ2, Q6FI82	Gene names	CRLZ1, SAS10
Domain Architecture	No domain graphic available
Description	Something about silencing protein 10 (Disrupter of silencing SAS10) (Charged amino acid-rich leucine zipper 1).

SEPT7_MOUSE
θ value	8.99809 (rank : 1562)	NC score	0.026901 (rank : 2073)
Query Neighborhood Hits	1580	Target Neighborhood Hits	327	Shared Neighborhood Hits	158
SwissProt Accessions	O55131	Gene names	Sept7, Cdc10
Domain Architecture
Description	Septin-7 (CDC10 protein homolog).

SF3B1_HUMAN
θ value	8.99809 (rank : 1563)	NC score	0.010415 (rank : 2130)
Query Neighborhood Hits	1580	Target Neighborhood Hits	341	Shared Neighborhood Hits	52
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	8.99809 (rank : 1564)	NC score	0.010905 (rank : 2126)
Query Neighborhood Hits	1580	Target Neighborhood Hits	352	Shared Neighborhood Hits	54
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SHLB1_HUMAN
θ value	8.99809 (rank : 1565)	NC score	0.016381 (rank : 2104)
Query Neighborhood Hits	1580	Target Neighborhood Hits	96	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SMC4_MOUSE
θ value	8.99809 (rank : 1566)	NC score	0.107372 (rank : 1392)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	287
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

STAM1_HUMAN
θ value	8.99809 (rank : 1567)	NC score	0.073471 (rank : 1680)
Query Neighborhood Hits	1580	Target Neighborhood Hits	271	Shared Neighborhood Hits	104
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STIM1_HUMAN
θ value	8.99809 (rank : 1568)	NC score	0.082787 (rank : 1594)
Query Neighborhood Hits	1580	Target Neighborhood Hits	665	Shared Neighborhood Hits	256
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STK31_MOUSE
θ value	8.99809 (rank : 1569)	NC score	0.318899 (rank : 845)
Query Neighborhood Hits	1580	Target Neighborhood Hits	474	Shared Neighborhood Hits	410
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

TARA_MOUSE
θ value	8.99809 (rank : 1570)	NC score	0.083500 (rank : 1583)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1133	Shared Neighborhood Hits	331
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TEX15_HUMAN
θ value	8.99809 (rank : 1571)	NC score	0.010317 (rank : 2131)
Query Neighborhood Hits	1580	Target Neighborhood Hits	174	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BXT5	Gene names	TEX15
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 15 protein.

THUM1_MOUSE
θ value	8.99809 (rank : 1572)	NC score	0.002278 (rank : 2167)
Query Neighborhood Hits	1580	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q99J36, Q3U6Y3	Gene names	Thumpd1
Domain Architecture
Description	THUMP domain-containing protein 1.

TPM3_MOUSE
θ value	8.99809 (rank : 1573)	NC score	0.108101 (rank : 1384)
Query Neighborhood Hits	1580	Target Neighborhood Hits	676	Shared Neighborhood Hits	268
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

TPSNR_MOUSE
θ value	8.99809 (rank : 1574)	NC score	0.013056 (rank : 2115)
Query Neighborhood Hits	1580	Target Neighborhood Hits	336	Shared Neighborhood Hits	78
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

UBE3A_MOUSE
θ value	8.99809 (rank : 1575)	NC score	-0.004791 (rank : 2190)
Query Neighborhood Hits	1580	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

VAX1_HUMAN
θ value	8.99809 (rank : 1576)	NC score	-0.018137 (rank : 2207)
Query Neighborhood Hits	1580	Target Neighborhood Hits	355	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SQQ9, Q6ZSX0	Gene names	VAX1
Domain Architecture	No domain graphic available
Description	Ventral anterior homeobox 1.

ZAR1_HUMAN
θ value	8.99809 (rank : 1577)	NC score	0.017601 (rank : 2099)
Query Neighborhood Hits	1580	Target Neighborhood Hits	163	Shared Neighborhood Hits	31
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

ZFAN3_MOUSE
θ value	8.99809 (rank : 1578)	NC score	0.001457 (rank : 2174)
Query Neighborhood Hits	1580	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q497H0, Q8K230, Q8R2V7, Q8R3V1	Gene names	Zfand3, Tex27
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 3 (Testis-expressed sequence 27).

ZN142_HUMAN
θ value	8.99809 (rank : 1579)	NC score	-0.027503 (rank : 2212)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1007	Shared Neighborhood Hits	58
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ZNF81_HUMAN
θ value	8.99809 (rank : 1580)	NC score	-0.029086 (rank : 2218)
Query Neighborhood Hits	1580	Target Neighborhood Hits	786	Shared Neighborhood Hits	21
SwissProt Accessions	P51508, Q6RX22, Q96QH6	Gene names	ZNF81
Domain Architecture	No domain graphic available
Description	Zinc finger protein 81 (HFZ20).

3BP5_HUMAN
θ value	θ > 10 (rank : 1581)	NC score	0.090091 (rank : 1519)
Query Neighborhood Hits	1580	Target Neighborhood Hits	375	Shared Neighborhood Hits	189
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

3BP5_MOUSE
θ value	θ > 10 (rank : 1582)	NC score	0.087142 (rank : 1543)
Query Neighborhood Hits	1580	Target Neighborhood Hits	346	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

A20A1_HUMAN
θ value	θ > 10 (rank : 1583)	NC score	0.052350 (rank : 1978)
Query Neighborhood Hits	1580	Target Neighborhood Hits	698	Shared Neighborhood Hits	234
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

A20A2_HUMAN
θ value	θ > 10 (rank : 1584)	NC score	0.051116 (rank : 1997)
Query Neighborhood Hits	1580	Target Neighborhood Hits	716	Shared Neighborhood Hits	234
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A3_HUMAN
θ value	θ > 10 (rank : 1585)	NC score	0.050996 (rank : 2000)
Query Neighborhood Hits	1580	Target Neighborhood Hits	692	Shared Neighborhood Hits	229
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	θ > 10 (rank : 1586)	NC score	0.053763 (rank : 1951)
Query Neighborhood Hits	1580	Target Neighborhood Hits	710	Shared Neighborhood Hits	236
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

AAT1_HUMAN
θ value	θ > 10 (rank : 1587)	NC score	0.051548 (rank : 1989)
Query Neighborhood Hits	1580	Target Neighborhood Hits	199	Shared Neighborhood Hits	114
SwissProt Accessions	Q7Z4T9, Q68DX2, Q8TD41, Q96A45, Q96JE8	Gene names	AAT1, C3orf15
Domain Architecture	No domain graphic available
Description	AMY-1-associating protein expressed in testis 1 (AAT-1).

ABI2_MOUSE
θ value	θ > 10 (rank : 1588)	NC score	0.058023 (rank : 1879)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	92
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ACINU_HUMAN
θ value	θ > 10 (rank : 1589)	NC score	0.055290 (rank : 1920)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	225
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ACINU_MOUSE
θ value	θ > 10 (rank : 1590)	NC score	0.061005 (rank : 1827)
Query Neighborhood Hits	1580	Target Neighborhood Hits	712	Shared Neighborhood Hits	223
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ACVL1_HUMAN
θ value	θ > 10 (rank : 1591)	NC score	0.538606 (rank : 807)
Query Neighborhood Hits	1580	Target Neighborhood Hits	716	Shared Neighborhood Hits	695
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVL1_MOUSE
θ value	θ > 10 (rank : 1592)	NC score	0.558480 (rank : 801)
Query Neighborhood Hits	1580	Target Neighborhood Hits	739	Shared Neighborhood Hits	718
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_HUMAN
θ value	θ > 10 (rank : 1593)	NC score	0.598401 (rank : 758)
Query Neighborhood Hits	1580	Target Neighborhood Hits	760	Shared Neighborhood Hits	737
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

ACVR1_MOUSE
θ value	θ > 10 (rank : 1594)	NC score	0.604015 (rank : 755)
Query Neighborhood Hits	1580	Target Neighborhood Hits	768	Shared Neighborhood Hits	742
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

ADIP_HUMAN
θ value	θ > 10 (rank : 1595)	NC score	0.095447 (rank : 1481)
Query Neighborhood Hits	1580	Target Neighborhood Hits	470	Shared Neighborhood Hits	214
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

ADIP_MOUSE
θ value	θ > 10 (rank : 1596)	NC score	0.088068 (rank : 1538)
Query Neighborhood Hits	1580	Target Neighborhood Hits	415	Shared Neighborhood Hits	200
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

AFAD_HUMAN
θ value	θ > 10 (rank : 1597)	NC score	0.050303 (rank : 2016)
Query Neighborhood Hits	1580	Target Neighborhood Hits	689	Shared Neighborhood Hits	214
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

AL2SB_HUMAN
θ value	θ > 10 (rank : 1598)	NC score	0.097766 (rank : 1457)
Query Neighborhood Hits	1580	Target Neighborhood Hits	294	Shared Neighborhood Hits	163
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

AMHR2_HUMAN
θ value	θ > 10 (rank : 1599)	NC score	0.478793 (rank : 817)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	647
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

AMOL2_HUMAN
θ value	θ > 10 (rank : 1600)	NC score	0.101283 (rank : 1435)
Query Neighborhood Hits	1580	Target Neighborhood Hits	603	Shared Neighborhood Hits	249
SwissProt Accessions	Q9Y2J4, Q53EP1, Q96F99, Q9UKB4	Gene names	AMOTL2, KIAA0989
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP).

AMOL2_MOUSE
θ value	θ > 10 (rank : 1601)	NC score	0.097907 (rank : 1456)
Query Neighborhood Hits	1580	Target Neighborhood Hits	591	Shared Neighborhood Hits	242
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

AMOT_HUMAN
θ value	θ > 10 (rank : 1602)	NC score	0.102591 (rank : 1426)
Query Neighborhood Hits	1580	Target Neighborhood Hits	712	Shared Neighborhood Hits	265
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

AMRP_MOUSE
θ value	θ > 10 (rank : 1603)	NC score	0.054997 (rank : 1928)
Query Neighborhood Hits	1580	Target Neighborhood Hits	173	Shared Neighborhood Hits	109
SwissProt Accessions	P55302	Gene names	Lrpap1
Domain Architecture
Description	Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2- MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin-binding protein 44) (HBP-44).

ANM2_HUMAN
θ value	θ > 10 (rank : 1604)	NC score	0.056233 (rank : 1910)
Query Neighborhood Hits	1580	Target Neighborhood Hits	175	Shared Neighborhood Hits	78
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 1605)	NC score	0.051753 (rank : 1986)
Query Neighborhood Hits	1580	Target Neighborhood Hits	175	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANPRA_HUMAN
θ value	θ > 10 (rank : 1606)	NC score	0.393603 (rank : 835)
Query Neighborhood Hits	1580	Target Neighborhood Hits	612	Shared Neighborhood Hits	533
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
θ value	θ > 10 (rank : 1607)	NC score	0.393380 (rank : 836)
Query Neighborhood Hits	1580	Target Neighborhood Hits	600	Shared Neighborhood Hits	527
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANR12_HUMAN
θ value	θ > 10 (rank : 1608)	NC score	0.057163 (rank : 1896)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1081	Shared Neighborhood Hits	253
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

ANR18_HUMAN
θ value	θ > 10 (rank : 1609)	NC score	0.074965 (rank : 1663)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1106	Shared Neighborhood Hits	295
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ANR26_MOUSE
θ value	θ > 10 (rank : 1610)	NC score	0.117912 (rank : 1309)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1554	Shared Neighborhood Hits	371
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

APOA1_MOUSE
θ value	θ > 10 (rank : 1611)	NC score	0.057701 (rank : 1884)
Query Neighborhood Hits	1580	Target Neighborhood Hits	210	Shared Neighborhood Hits	123
SwissProt Accessions	Q00623	Gene names	Apoa1
Domain Architecture
Description	Apolipoprotein A-I precursor (Apo-AI) (ApoA-I).

APOA4_HUMAN
θ value	θ > 10 (rank : 1612)	NC score	0.094953 (rank : 1482)
Query Neighborhood Hits	1580	Target Neighborhood Hits	399	Shared Neighborhood Hits	193
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

APOA4_MOUSE
θ value	θ > 10 (rank : 1613)	NC score	0.093560 (rank : 1490)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	189
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

APOE_HUMAN
θ value	θ > 10 (rank : 1614)	NC score	0.050687 (rank : 2005)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	108
SwissProt Accessions	P02649, Q9P2S4	Gene names	APOE
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

APS_HUMAN
θ value	θ > 10 (rank : 1615)	NC score	0.055376 (rank : 1919)
Query Neighborhood Hits	1580	Target Neighborhood Hits	162	Shared Neighborhood Hits	64
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ASPP1_HUMAN
θ value	θ > 10 (rank : 1616)	NC score	0.081817 (rank : 1605)
Query Neighborhood Hits	1580	Target Neighborhood Hits	956	Shared Neighborhood Hits	320
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP2_HUMAN
θ value	θ > 10 (rank : 1617)	NC score	0.096654 (rank : 1470)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1156	Shared Neighborhood Hits	362
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAP29_HUMAN
θ value	θ > 10 (rank : 1618)	NC score	0.060690 (rank : 1835)
Query Neighborhood Hits	1580	Target Neighborhood Hits	362	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UHQ4, O95003	Gene names	BCAP29, BAP29
Domain Architecture
Description	B-cell receptor-associated protein 29 (BCR-associated protein Bap29).

BAP29_MOUSE
θ value	θ > 10 (rank : 1619)	NC score	0.051547 (rank : 1990)
Query Neighborhood Hits	1580	Target Neighborhood Hits	285	Shared Neighborhood Hits	146
SwissProt Accessions	Q61334	Gene names	Bcap29, Bap29
Domain Architecture
Description	B-cell receptor-associated protein 29 (BCR-associated protein Bap29).

BAZ2B_HUMAN
θ value	θ > 10 (rank : 1620)	NC score	0.054841 (rank : 1931)
Query Neighborhood Hits	1580	Target Neighborhood Hits	803	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

BCN1_HUMAN
θ value	θ > 10 (rank : 1621)	NC score	0.072406 (rank : 1690)
Query Neighborhood Hits	1580	Target Neighborhood Hits	395	Shared Neighborhood Hits	205
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

BCN1_MOUSE
θ value	θ > 10 (rank : 1622)	NC score	0.066774 (rank : 1753)
Query Neighborhood Hits	1580	Target Neighborhood Hits	367	Shared Neighborhood Hits	190
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

BEGIN_HUMAN
θ value	θ > 10 (rank : 1623)	NC score	0.057260 (rank : 1895)
Query Neighborhood Hits	1580	Target Neighborhood Hits	454	Shared Neighborhood Hits	199
SwissProt Accessions	Q9BUH8, Q9NPU3, Q9P282	Gene names	BEGAIN, KIAA1446
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

BEGIN_MOUSE
θ value	θ > 10 (rank : 1624)	NC score	0.052423 (rank : 1977)
Query Neighborhood Hits	1580	Target Neighborhood Hits	383	Shared Neighborhood Hits	181
SwissProt Accessions	Q68EF6	Gene names	Begain
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

BFSP1_HUMAN
θ value	θ > 10 (rank : 1625)	NC score	0.064722 (rank : 1774)
Query Neighborhood Hits	1580	Target Neighborhood Hits	508	Shared Neighborhood Hits	227
SwissProt Accessions	Q12934, O43595, O76034, Q9HBX4	Gene names	BFSP1
Domain Architecture
Description	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H).

BICD1_HUMAN
θ value	θ > 10 (rank : 1626)	NC score	0.118027 (rank : 1307)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	303
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD1_MOUSE
θ value	θ > 10 (rank : 1627)	NC score	0.116344 (rank : 1326)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	296
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

BICD2_HUMAN
θ value	θ > 10 (rank : 1628)	NC score	0.112160 (rank : 1358)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	288
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BICD2_MOUSE
θ value	θ > 10 (rank : 1629)	NC score	0.113729 (rank : 1348)
Query Neighborhood Hits	1580	Target Neighborhood Hits	864	Shared Neighborhood Hits	287
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

BMPR2_HUMAN
θ value	θ > 10 (rank : 1630)	NC score	0.565576 (rank : 795)
Query Neighborhood Hits	1580	Target Neighborhood Hits	736	Shared Neighborhood Hits	691
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
θ value	θ > 10 (rank : 1631)	NC score	0.564433 (rank : 796)
Query Neighborhood Hits	1580	Target Neighborhood Hits	738	Shared Neighborhood Hits	691
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

BMR1B_HUMAN
θ value	θ > 10 (rank : 1632)	NC score	0.577576 (rank : 787)
Query Neighborhood Hits	1580	Target Neighborhood Hits	760	Shared Neighborhood Hits	727
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

BMR1B_MOUSE
θ value	θ > 10 (rank : 1633)	NC score	0.578822 (rank : 785)
Query Neighborhood Hits	1580	Target Neighborhood Hits	758	Shared Neighborhood Hits	728
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

BRAP_HUMAN
θ value	θ > 10 (rank : 1634)	NC score	0.069674 (rank : 1719)
Query Neighborhood Hits	1580	Target Neighborhood Hits	560	Shared Neighborhood Hits	210
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

BUB1B_MOUSE
θ value	θ > 10 (rank : 1635)	NC score	0.084755 (rank : 1564)
Query Neighborhood Hits	1580	Target Neighborhood Hits	202	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

CA065_HUMAN
θ value	θ > 10 (rank : 1636)	NC score	0.107934 (rank : 1386)
Query Neighborhood Hits	1580	Target Neighborhood Hits	469	Shared Neighborhood Hits	211
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

CAF1A_HUMAN
θ value	θ > 10 (rank : 1637)	NC score	0.084417 (rank : 1570)
Query Neighborhood Hits	1580	Target Neighborhood Hits	750	Shared Neighborhood Hits	246
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CAF1A_MOUSE
θ value	θ > 10 (rank : 1638)	NC score	0.089083 (rank : 1525)
Query Neighborhood Hits	1580	Target Neighborhood Hits	736	Shared Neighborhood Hits	253
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

CALD1_HUMAN
θ value	θ > 10 (rank : 1639)	NC score	0.127537 (rank : 1232)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	294
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

CAR10_HUMAN
θ value	θ > 10 (rank : 1640)	NC score	0.082062 (rank : 1603)
Query Neighborhood Hits	1580	Target Neighborhood Hits	569	Shared Neighborhood Hits	246
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

CAR10_MOUSE
θ value	θ > 10 (rank : 1641)	NC score	0.060224 (rank : 1841)
Query Neighborhood Hits	1580	Target Neighborhood Hits	407	Shared Neighborhood Hits	202
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

CAR11_HUMAN
θ value	θ > 10 (rank : 1642)	NC score	0.098499 (rank : 1454)
Query Neighborhood Hits	1580	Target Neighborhood Hits	690	Shared Neighborhood Hits	268
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

CAR14_HUMAN
θ value	θ > 10 (rank : 1643)	NC score	0.067562 (rank : 1744)
Query Neighborhood Hits	1580	Target Neighborhood Hits	449	Shared Neighborhood Hits	197
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CAR14_MOUSE
θ value	θ > 10 (rank : 1644)	NC score	0.078556 (rank : 1627)
Query Neighborhood Hits	1580	Target Neighborhood Hits	526	Shared Neighborhood Hits	227
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

CARD9_HUMAN
θ value	θ > 10 (rank : 1645)	NC score	0.119579 (rank : 1296)
Query Neighborhood Hits	1580	Target Neighborhood Hits	602	Shared Neighborhood Hits	268
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

CASC5_HUMAN
θ value	θ > 10 (rank : 1646)	NC score	0.057608 (rank : 1888)
Query Neighborhood Hits	1580	Target Neighborhood Hits	376	Shared Neighborhood Hits	171
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

CCAR1_HUMAN
θ value	θ > 10 (rank : 1647)	NC score	0.052973 (rank : 1968)
Query Neighborhood Hits	1580	Target Neighborhood Hits	444	Shared Neighborhood Hits	177
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

CCD11_HUMAN
θ value	θ > 10 (rank : 1648)	NC score	0.133868 (rank : 1177)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	295
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD11_MOUSE
θ value	θ > 10 (rank : 1649)	NC score	0.127701 (rank : 1228)
Query Neighborhood Hits	1580	Target Neighborhood Hits	498	Shared Neighborhood Hits	222
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CCD19_HUMAN
θ value	θ > 10 (rank : 1650)	NC score	0.131864 (rank : 1195)
Query Neighborhood Hits	1580	Target Neighborhood Hits	639	Shared Neighborhood Hits	258
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

CCD22_HUMAN
θ value	θ > 10 (rank : 1651)	NC score	0.062873 (rank : 1795)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	142
SwissProt Accessions	O60826	Gene names	CCDC22, CXorf37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CCD22_MOUSE
θ value	θ > 10 (rank : 1652)	NC score	0.067591 (rank : 1743)
Query Neighborhood Hits	1580	Target Neighborhood Hits	268	Shared Neighborhood Hits	149
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CCD27_HUMAN
θ value	θ > 10 (rank : 1653)	NC score	0.115927 (rank : 1330)
Query Neighborhood Hits	1580	Target Neighborhood Hits	594	Shared Neighborhood Hits	255
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

CCD38_HUMAN
θ value	θ > 10 (rank : 1654)	NC score	0.057064 (rank : 1898)
Query Neighborhood Hits	1580	Target Neighborhood Hits	287	Shared Neighborhood Hits	152
SwissProt Accessions	Q502W7, Q8N835	Gene names	CCDC38
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 38.

CCD39_HUMAN
θ value	θ > 10 (rank : 1655)	NC score	0.135802 (rank : 1163)
Query Neighborhood Hits	1580	Target Neighborhood Hits	868	Shared Neighborhood Hits	304
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

CCD42_HUMAN
θ value	θ > 10 (rank : 1656)	NC score	0.097142 (rank : 1460)
Query Neighborhood Hits	1580	Target Neighborhood Hits	406	Shared Neighborhood Hits	214
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

CCD42_MOUSE
θ value	θ > 10 (rank : 1657)	NC score	0.078338 (rank : 1628)
Query Neighborhood Hits	1580	Target Neighborhood Hits	284	Shared Neighborhood Hits	171
SwissProt Accessions	Q5SV66, Q8BNY1	Gene names	Ccdc42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

CCD45_HUMAN
θ value	θ > 10 (rank : 1658)	NC score	0.093420 (rank : 1492)
Query Neighborhood Hits	1580	Target Neighborhood Hits	525	Shared Neighborhood Hits	230
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCD45_MOUSE
θ value	θ > 10 (rank : 1659)	NC score	0.099575 (rank : 1445)
Query Neighborhood Hits	1580	Target Neighborhood Hits	663	Shared Neighborhood Hits	238
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CCD93_HUMAN
θ value	θ > 10 (rank : 1660)	NC score	0.115664 (rank : 1333)
Query Neighborhood Hits	1580	Target Neighborhood Hits	600	Shared Neighborhood Hits	255
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD93_MOUSE
θ value	θ > 10 (rank : 1661)	NC score	0.095854 (rank : 1478)
Query Neighborhood Hits	1580	Target Neighborhood Hits	362	Shared Neighborhood Hits	197
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CCD96_HUMAN
θ value	θ > 10 (rank : 1662)	NC score	0.111383 (rank : 1362)
Query Neighborhood Hits	1580	Target Neighborhood Hits	595	Shared Neighborhood Hits	254
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCD96_MOUSE
θ value	θ > 10 (rank : 1663)	NC score	0.115004 (rank : 1337)
Query Neighborhood Hits	1580	Target Neighborhood Hits	704	Shared Neighborhood Hits	275
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

CCDC6_HUMAN
θ value	θ > 10 (rank : 1664)	NC score	0.117631 (rank : 1313)
Query Neighborhood Hits	1580	Target Neighborhood Hits	723	Shared Neighborhood Hits	279
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CCDC7_HUMAN
θ value	θ > 10 (rank : 1665)	NC score	0.072360 (rank : 1691)
Query Neighborhood Hits	1580	Target Neighborhood Hits	253	Shared Neighborhood Hits	129
SwissProt Accessions	Q96M83, Q8IVQ0, Q8NEQ0	Gene names	CCDC7
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 7.

CCHCR_HUMAN
θ value	θ > 10 (rank : 1666)	NC score	0.130253 (rank : 1208)
Query Neighborhood Hits	1580	Target Neighborhood Hits	717	Shared Neighborhood Hits	277
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

CCHCR_MOUSE
θ value	θ > 10 (rank : 1667)	NC score	0.130625 (rank : 1204)
Query Neighborhood Hits	1580	Target Neighborhood Hits	932	Shared Neighborhood Hits	308
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

CD166_HUMAN
θ value	θ > 10 (rank : 1668)	NC score	0.088783 (rank : 1527)
Query Neighborhood Hits	1580	Target Neighborhood Hits	247	Shared Neighborhood Hits	159
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

CD22_HUMAN
θ value	θ > 10 (rank : 1669)	NC score	0.131646 (rank : 1200)
Query Neighborhood Hits	1580	Target Neighborhood Hits	365	Shared Neighborhood Hits	213
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

CD2AP_HUMAN
θ value	θ > 10 (rank : 1670)	NC score	0.079169 (rank : 1619)
Query Neighborhood Hits	1580	Target Neighborhood Hits	315	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CDC37_HUMAN
θ value	θ > 10 (rank : 1671)	NC score	0.072274 (rank : 1692)
Query Neighborhood Hits	1580	Target Neighborhood Hits	506	Shared Neighborhood Hits	206
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CDC37_MOUSE
θ value	θ > 10 (rank : 1672)	NC score	0.059460 (rank : 1853)
Query Neighborhood Hits	1580	Target Neighborhood Hits	359	Shared Neighborhood Hits	169
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CEAM1_HUMAN
θ value	θ > 10 (rank : 1673)	NC score	0.102072 (rank : 1429)
Query Neighborhood Hits	1580	Target Neighborhood Hits	348	Shared Neighborhood Hits	196
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

CEAM6_HUMAN
θ value	θ > 10 (rank : 1674)	NC score	0.083435 (rank : 1584)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	198
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

CEAM8_HUMAN
θ value	θ > 10 (rank : 1675)	NC score	0.073030 (rank : 1684)
Query Neighborhood Hits	1580	Target Neighborhood Hits	264	Shared Neighborhood Hits	185
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

CENPH_HUMAN
θ value	θ > 10 (rank : 1676)	NC score	0.090956 (rank : 1512)
Query Neighborhood Hits	1580	Target Neighborhood Hits	335	Shared Neighborhood Hits	184
SwissProt Accessions	Q9H3R5	Gene names	CENPH, ICEN35
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H) (Interphase centromere complex protein 35).

CENPH_MOUSE
θ value	θ > 10 (rank : 1677)	NC score	0.066837 (rank : 1750)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	123
SwissProt Accessions	Q9QYM8, Q8R3K9, Q9D079, Q9D0N1	Gene names	Cenph, Enp
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H).

CENPJ_HUMAN
θ value	θ > 10 (rank : 1678)	NC score	0.091520 (rank : 1510)
Query Neighborhood Hits	1580	Target Neighborhood Hits	721	Shared Neighborhood Hits	271
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

CENPK_HUMAN
θ value	θ > 10 (rank : 1679)	NC score	0.069178 (rank : 1725)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BS16, Q9H4L0	Gene names	CENPK, ICEN37
Domain Architecture	No domain graphic available
Description	Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33).

CENPU_HUMAN
θ value	θ > 10 (rank : 1680)	NC score	0.062858 (rank : 1796)
Query Neighborhood Hits	1580	Target Neighborhood Hits	289	Shared Neighborhood Hits	156
SwissProt Accessions	Q71F23, Q32Q71, Q9H5G1	Gene names	MLF1IP, CENPU, ICEN24, KLIP1
Domain Architecture	No domain graphic available
Description	Centromere protein U (CENP-U) (CENP-U(50)) (CENP-50) (Interphase centromere complex protein 24) (MLF1-interacting protein) (KSHV latent nuclear antigen-interacting protein 1).

CEP35_HUMAN
θ value	θ > 10 (rank : 1681)	NC score	0.084374 (rank : 1572)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	263
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

CEP55_HUMAN
θ value	θ > 10 (rank : 1682)	NC score	0.112705 (rank : 1354)
Query Neighborhood Hits	1580	Target Neighborhood Hits	504	Shared Neighborhood Hits	246
SwissProt Accessions	Q53EZ4, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7	Gene names	CEP55, C10orf3, URCC6
Domain Architecture	No domain graphic available
Description	Centrosome protein 55 (Up-regulated in colon cancer 6).

CEP55_MOUSE
θ value	θ > 10 (rank : 1683)	NC score	0.113543 (rank : 1350)
Query Neighborhood Hits	1580	Target Neighborhood Hits	693	Shared Neighborhood Hits	272
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

CEP57_HUMAN
θ value	θ > 10 (rank : 1684)	NC score	0.096899 (rank : 1465)
Query Neighborhood Hits	1580	Target Neighborhood Hits	576	Shared Neighborhood Hits	257
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

CEP57_MOUSE
θ value	θ > 10 (rank : 1685)	NC score	0.092013 (rank : 1509)
Query Neighborhood Hits	1580	Target Neighborhood Hits	580	Shared Neighborhood Hits	257
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

CEP70_HUMAN
θ value	θ > 10 (rank : 1686)	NC score	0.104037 (rank : 1414)
Query Neighborhood Hits	1580	Target Neighborhood Hits	432	Shared Neighborhood Hits	215
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

CEP70_MOUSE
θ value	θ > 10 (rank : 1687)	NC score	0.105054 (rank : 1408)
Query Neighborhood Hits	1580	Target Neighborhood Hits	532	Shared Neighborhood Hits	236
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

CEP72_HUMAN
θ value	θ > 10 (rank : 1688)	NC score	0.052502 (rank : 1976)
Query Neighborhood Hits	1580	Target Neighborhood Hits	374	Shared Neighborhood Hits	161
SwissProt Accessions	Q9P209, Q9BV03, Q9BWM3, Q9NVR4	Gene names	CEP72, KIAA1519
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

CEP72_MOUSE
θ value	θ > 10 (rank : 1689)	NC score	0.065042 (rank : 1769)
Query Neighborhood Hits	1580	Target Neighborhood Hits	381	Shared Neighborhood Hits	172
SwissProt Accessions	Q9D3R3, Q8BM53, Q9D0B7	Gene names	Cep72
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

CF152_HUMAN
θ value	θ > 10 (rank : 1690)	NC score	0.106043 (rank : 1403)
Query Neighborhood Hits	1580	Target Neighborhood Hits	704	Shared Neighborhood Hits	265
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

CF152_MOUSE
θ value	θ > 10 (rank : 1691)	NC score	0.089270 (rank : 1524)
Query Neighborhood Hits	1580	Target Neighborhood Hits	597	Shared Neighborhood Hits	238
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

CF182_HUMAN
θ value	θ > 10 (rank : 1692)	NC score	0.093790 (rank : 1489)
Query Neighborhood Hits	1580	Target Neighborhood Hits	474	Shared Neighborhood Hits	226
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

CF182_MOUSE
θ value	θ > 10 (rank : 1693)	NC score	0.105347 (rank : 1406)
Query Neighborhood Hits	1580	Target Neighborhood Hits	551	Shared Neighborhood Hits	243
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

CHCH3_MOUSE
θ value	θ > 10 (rank : 1694)	NC score	0.052644 (rank : 1973)
Query Neighborhood Hits	1580	Target Neighborhood Hits	249	Shared Neighborhood Hits	121
SwissProt Accessions	Q9CRB9	Gene names	Chchd3
Domain Architecture	No domain graphic available
Description	Coiled-coil-helix-coiled-coil-helix domain-containing protein 3.

CHIN_HUMAN
θ value	θ > 10 (rank : 1695)	NC score	0.083960 (rank : 1576)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 1696)	NC score	0.084786 (rank : 1561)
Query Neighborhood Hits	1580	Target Neighborhood Hits	229	Shared Neighborhood Hits	78
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_HUMAN
θ value	θ > 10 (rank : 1697)	NC score	0.084978 (rank : 1560)
Query Neighborhood Hits	1580	Target Neighborhood Hits	220	Shared Neighborhood Hits	75
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_MOUSE
θ value	θ > 10 (rank : 1698)	NC score	0.074998 (rank : 1661)
Query Neighborhood Hits	1580	Target Neighborhood Hits	130	Shared Neighborhood Hits	46
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CILP1_HUMAN
θ value	θ > 10 (rank : 1699)	NC score	0.058685 (rank : 1869)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	144
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CILP1_MOUSE
θ value	θ > 10 (rank : 1700)	NC score	0.063542 (rank : 1786)
Query Neighborhood Hits	1580	Target Neighborhood Hits	282	Shared Neighborhood Hits	157
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

CILP2_HUMAN
θ value	θ > 10 (rank : 1701)	NC score	0.075989 (rank : 1650)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	160
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

CIP4_HUMAN
θ value	θ > 10 (rank : 1702)	NC score	0.092057 (rank : 1507)
Query Neighborhood Hits	1580	Target Neighborhood Hits	374	Shared Neighborhood Hits	182
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CJ068_HUMAN
θ value	θ > 10 (rank : 1703)	NC score	0.073228 (rank : 1683)
Query Neighborhood Hits	1580	Target Neighborhood Hits	316	Shared Neighborhood Hits	131
SwissProt Accessions	Q9H943, Q8N7T7	Gene names	C10orf68
Domain Architecture	No domain graphic available
Description	Protein C10orf68.

CKAP4_HUMAN
θ value	θ > 10 (rank : 1704)	NC score	0.111776 (rank : 1360)
Query Neighborhood Hits	1580	Target Neighborhood Hits	592	Shared Neighborhood Hits	236
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CKAP4_MOUSE
θ value	θ > 10 (rank : 1705)	NC score	0.114134 (rank : 1344)
Query Neighborhood Hits	1580	Target Neighborhood Hits	596	Shared Neighborhood Hits	244
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CLC4F_HUMAN
θ value	θ > 10 (rank : 1706)	NC score	0.090287 (rank : 1516)
Query Neighborhood Hits	1580	Target Neighborhood Hits	513	Shared Neighborhood Hits	206
SwissProt Accessions	Q8N1N0	Gene names	CLEC4F, CLECSF13
Domain Architecture	No domain graphic available
Description	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13).

CLC4F_MOUSE
θ value	θ > 10 (rank : 1707)	NC score	0.068104 (rank : 1738)
Query Neighborhood Hits	1580	Target Neighborhood Hits	572	Shared Neighborhood Hits	212
SwissProt Accessions	P70194, Q8BLZ8	Gene names	Clec4f, Clecsf13, Kclr
Domain Architecture
Description	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor).

CLMN_MOUSE
θ value	θ > 10 (rank : 1708)	NC score	0.083365 (rank : 1585)
Query Neighborhood Hits	1580	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

CLUA1_HUMAN
θ value	θ > 10 (rank : 1709)	NC score	0.055984 (rank : 1914)
Query Neighborhood Hits	1580	Target Neighborhood Hits	236	Shared Neighborhood Hits	126
SwissProt Accessions	Q96AJ1, O75138, Q65ZA3, Q9H8R4, Q9H8T1	Gene names	CLUAP1, KIAA0643
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

CLUA1_MOUSE
θ value	θ > 10 (rank : 1710)	NC score	0.068112 (rank : 1737)
Query Neighborhood Hits	1580	Target Neighborhood Hits	261	Shared Neighborhood Hits	143
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

CN045_HUMAN
θ value	θ > 10 (rank : 1711)	NC score	0.070260 (rank : 1713)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	138
SwissProt Accessions	Q8ND07, Q9H5P8	Gene names	C14orf45
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf45.

CN145_HUMAN
θ value	θ > 10 (rank : 1712)	NC score	0.138025 (rank : 1144)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1196	Shared Neighborhood Hits	355
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

CN145_MOUSE
θ value	θ > 10 (rank : 1713)	NC score	0.130359 (rank : 1207)
Query Neighborhood Hits	1580	Target Neighborhood Hits	916	Shared Neighborhood Hits	304
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

CNOT3_HUMAN
θ value	θ > 10 (rank : 1714)	NC score	0.051089 (rank : 1998)
Query Neighborhood Hits	1580	Target Neighborhood Hits	425	Shared Neighborhood Hits	164
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CNOT3_MOUSE
θ value	θ > 10 (rank : 1715)	NC score	0.056655 (rank : 1905)
Query Neighborhood Hits	1580	Target Neighborhood Hits	504	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CNTRB_HUMAN
θ value	θ > 10 (rank : 1716)	NC score	0.121417 (rank : 1277)
Query Neighborhood Hits	1580	Target Neighborhood Hits	690	Shared Neighborhood Hits	271
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

COCA1_MOUSE
θ value	θ > 10 (rank : 1717)	NC score	0.050728 (rank : 2003)
Query Neighborhood Hits	1580	Target Neighborhood Hits	467	Shared Neighborhood Hits	152
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

COVA1_HUMAN
θ value	θ > 10 (rank : 1718)	NC score	0.080813 (rank : 1610)
Query Neighborhood Hits	1580	Target Neighborhood Hits	416	Shared Neighborhood Hits	193
SwissProt Accessions	Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82	Gene names	COVA1
Domain Architecture
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

CRCM_HUMAN
θ value	θ > 10 (rank : 1719)	NC score	0.101218 (rank : 1436)
Query Neighborhood Hits	1580	Target Neighborhood Hits	520	Shared Neighborhood Hits	230
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

CRKL_HUMAN
θ value	θ > 10 (rank : 1720)	NC score	0.096108 (rank : 1477)
Query Neighborhood Hits	1580	Target Neighborhood Hits	313	Shared Neighborhood Hits	99
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 1721)	NC score	0.096125 (rank : 1476)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	97
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 1722)	NC score	0.088184 (rank : 1534)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	100
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 1723)	NC score	0.088276 (rank : 1533)
Query Neighborhood Hits	1580	Target Neighborhood Hits	314	Shared Neighborhood Hits	100
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CROP_HUMAN
θ value	θ > 10 (rank : 1724)	NC score	0.060863 (rank : 1829)
Query Neighborhood Hits	1580	Target Neighborhood Hits	402	Shared Neighborhood Hits	167
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

CROP_MOUSE
θ value	θ > 10 (rank : 1725)	NC score	0.059396 (rank : 1854)
Query Neighborhood Hits	1580	Target Neighborhood Hits	403	Shared Neighborhood Hits	164
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

CT075_HUMAN
θ value	θ > 10 (rank : 1726)	NC score	0.053875 (rank : 1950)
Query Neighborhood Hits	1580	Target Neighborhood Hits	387	Shared Neighborhood Hits	103
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

CT116_HUMAN
θ value	θ > 10 (rank : 1727)	NC score	0.062485 (rank : 1804)
Query Neighborhood Hits	1580	Target Neighborhood Hits	294	Shared Neighborhood Hits	143
SwissProt Accessions	Q96HY6, Q9BW47	Gene names	C20orf116
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf116 precursor.

CT116_MOUSE
θ value	θ > 10 (rank : 1728)	NC score	0.053333 (rank : 1961)
Query Neighborhood Hits	1580	Target Neighborhood Hits	268	Shared Neighborhood Hits	124
SwissProt Accessions	Q80WW9, Q9CT52	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf116 homolog precursor.

CT151_HUMAN
θ value	θ > 10 (rank : 1729)	NC score	0.052746 (rank : 1971)
Query Neighborhood Hits	1580	Target Neighborhood Hits	382	Shared Neighborhood Hits	148
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

CT2NL_HUMAN
θ value	θ > 10 (rank : 1730)	NC score	0.103285 (rank : 1418)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1059	Shared Neighborhood Hits	312
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CT2NL_MOUSE
θ value	θ > 10 (rank : 1731)	NC score	0.100607 (rank : 1438)
Query Neighborhood Hits	1580	Target Neighborhood Hits	902	Shared Neighborhood Hits	288
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

CTGE4_HUMAN
θ value	θ > 10 (rank : 1732)	NC score	0.060112 (rank : 1843)
Query Neighborhood Hits	1580	Target Neighborhood Hits	393	Shared Neighborhood Hits	187
SwissProt Accessions	Q8IX94, O95046	Gene names	CTAGE4
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 4 (cTAGE-4 protein).

CTGE5_MOUSE
θ value	θ > 10 (rank : 1733)	NC score	0.110217 (rank : 1377)
Query Neighborhood Hits	1580	Target Neighborhood Hits	928	Shared Neighborhood Hits	305
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

CTGE6_HUMAN
θ value	θ > 10 (rank : 1734)	NC score	0.096820 (rank : 1467)
Query Neighborhood Hits	1580	Target Neighborhood Hits	650	Shared Neighborhood Hits	256
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

CTTB2_HUMAN
θ value	θ > 10 (rank : 1735)	NC score	0.061784 (rank : 1816)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1061	Shared Neighborhood Hits	310
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

CU013_HUMAN
θ value	θ > 10 (rank : 1736)	NC score	0.088656 (rank : 1529)
Query Neighborhood Hits	1580	Target Neighborhood Hits	405	Shared Neighborhood Hits	197
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

CUTL2_HUMAN
θ value	θ > 10 (rank : 1737)	NC score	0.068151 (rank : 1736)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	263
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CUTL2_MOUSE
θ value	θ > 10 (rank : 1738)	NC score	0.055132 (rank : 1924)
Query Neighborhood Hits	1580	Target Neighborhood Hits	771	Shared Neighborhood Hits	254
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CXAR_HUMAN
θ value	θ > 10 (rank : 1739)	NC score	0.069142 (rank : 1726)
Query Neighborhood Hits	1580	Target Neighborhood Hits	245	Shared Neighborhood Hits	139
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

CXAR_MOUSE
θ value	θ > 10 (rank : 1740)	NC score	0.066625 (rank : 1756)
Query Neighborhood Hits	1580	Target Neighborhood Hits	250	Shared Neighborhood Hits	141
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

CYLN2_MOUSE
θ value	θ > 10 (rank : 1741)	NC score	0.132251 (rank : 1191)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1002	Shared Neighborhood Hits	319
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

DAPP1_HUMAN
θ value	θ > 10 (rank : 1742)	NC score	0.067799 (rank : 1741)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 1743)	NC score	0.066414 (rank : 1758)
Query Neighborhood Hits	1580	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DCX_HUMAN
θ value	θ > 10 (rank : 1744)	NC score	0.074898 (rank : 1664)
Query Neighborhood Hits	1580	Target Neighborhood Hits	141	Shared Neighborhood Hits	33
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DCX_MOUSE
θ value	θ > 10 (rank : 1745)	NC score	0.071235 (rank : 1701)
Query Neighborhood Hits	1580	Target Neighborhood Hits	124	Shared Neighborhood Hits	23
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

DGKB_HUMAN
θ value	θ > 10 (rank : 1746)	NC score	0.055609 (rank : 1916)
Query Neighborhood Hits	1580	Target Neighborhood Hits	238	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

DGKD_HUMAN
θ value	θ > 10 (rank : 1747)	NC score	0.084591 (rank : 1568)
Query Neighborhood Hits	1580	Target Neighborhood Hits	231	Shared Neighborhood Hits	106
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

DGKG_HUMAN
θ value	θ > 10 (rank : 1748)	NC score	0.051973 (rank : 1981)
Query Neighborhood Hits	1580	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

DGKG_MOUSE
θ value	θ > 10 (rank : 1749)	NC score	0.052300 (rank : 1980)
Query Neighborhood Hits	1580	Target Neighborhood Hits	188	Shared Neighborhood Hits	44
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

DGKH_HUMAN
θ value	θ > 10 (rank : 1750)	NC score	0.079414 (rank : 1617)
Query Neighborhood Hits	1580	Target Neighborhood Hits	255	Shared Neighborhood Hits	90
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DGKQ_HUMAN
θ value	θ > 10 (rank : 1751)	NC score	0.070960 (rank : 1703)
Query Neighborhood Hits	1580	Target Neighborhood Hits	131	Shared Neighborhood Hits	43
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

DIAP1_HUMAN
θ value	θ > 10 (rank : 1752)	NC score	0.050257 (rank : 2018)
Query Neighborhood Hits	1580	Target Neighborhood Hits	784	Shared Neighborhood Hits	274
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

DIAP1_MOUSE
θ value	θ > 10 (rank : 1753)	NC score	0.061888 (rank : 1812)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	283
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

DLG5_HUMAN
θ value	θ > 10 (rank : 1754)	NC score	0.100334 (rank : 1441)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1088	Shared Neighborhood Hits	328
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

DREB_HUMAN
θ value	θ > 10 (rank : 1755)	NC score	0.065392 (rank : 1766)
Query Neighborhood Hits	1580	Target Neighborhood Hits	450	Shared Neighborhood Hits	192
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DREB_MOUSE
θ value	θ > 10 (rank : 1756)	NC score	0.064227 (rank : 1780)
Query Neighborhood Hits	1580	Target Neighborhood Hits	446	Shared Neighborhood Hits	194
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DRP2_HUMAN
θ value	θ > 10 (rank : 1757)	NC score	0.066733 (rank : 1754)
Query Neighborhood Hits	1580	Target Neighborhood Hits	186	Shared Neighborhood Hits	98
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

DYHC_HUMAN
θ value	θ > 10 (rank : 1758)	NC score	0.069515 (rank : 1720)
Query Neighborhood Hits	1580	Target Neighborhood Hits	733	Shared Neighborhood Hits	258
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
θ value	θ > 10 (rank : 1759)	NC score	0.069365 (rank : 1721)
Query Neighborhood Hits	1580	Target Neighborhood Hits	729	Shared Neighborhood Hits	259
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DZIP1_HUMAN
θ value	θ > 10 (rank : 1760)	NC score	0.073815 (rank : 1674)
Query Neighborhood Hits	1580	Target Neighborhood Hits	675	Shared Neighborhood Hits	179
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

EMIL2_HUMAN
θ value	θ > 10 (rank : 1761)	NC score	0.057787 (rank : 1881)
Query Neighborhood Hits	1580	Target Neighborhood Hits	573	Shared Neighborhood Hits	203
SwissProt Accessions	Q9BXX0, Q8NBH3, Q96JQ4	Gene names	EMILIN2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10).

ENAH_HUMAN
θ value	θ > 10 (rank : 1762)	NC score	0.082803 (rank : 1593)
Query Neighborhood Hits	1580	Target Neighborhood Hits	784	Shared Neighborhood Hits	272
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

ENAH_MOUSE
θ value	θ > 10 (rank : 1763)	NC score	0.054762 (rank : 1935)
Query Neighborhood Hits	1580	Target Neighborhood Hits	919	Shared Neighborhood Hits	268
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

EP15R_MOUSE
θ value	θ > 10 (rank : 1764)	NC score	0.109591 (rank : 1379)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1135	Shared Neighborhood Hits	332
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

ERBB3_HUMAN
θ value	θ > 10 (rank : 1765)	NC score	0.594821 (rank : 765)
Query Neighborhood Hits	1580	Target Neighborhood Hits	918	Shared Neighborhood Hits	756
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 1766)	NC score	0.597740 (rank : 760)
Query Neighborhood Hits	1580	Target Neighborhood Hits	898	Shared Neighborhood Hits	761
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

EZRI_HUMAN
θ value	θ > 10 (rank : 1767)	NC score	0.070551 (rank : 1709)
Query Neighborhood Hits	1580	Target Neighborhood Hits	663	Shared Neighborhood Hits	258
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

EZRI_MOUSE
θ value	θ > 10 (rank : 1768)	NC score	0.074117 (rank : 1672)
Query Neighborhood Hits	1580	Target Neighborhood Hits	693	Shared Neighborhood Hits	272
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FA50A_HUMAN
θ value	θ > 10 (rank : 1769)	NC score	0.063194 (rank : 1791)
Query Neighborhood Hits	1580	Target Neighborhood Hits	264	Shared Neighborhood Hits	152
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

FA50A_MOUSE
θ value	θ > 10 (rank : 1770)	NC score	0.071170 (rank : 1702)
Query Neighborhood Hits	1580	Target Neighborhood Hits	293	Shared Neighborhood Hits	165
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

FBX41_HUMAN
θ value	θ > 10 (rank : 1771)	NC score	0.056297 (rank : 1909)
Query Neighborhood Hits	1580	Target Neighborhood Hits	475	Shared Neighborhood Hits	189
SwissProt Accessions	Q8TF61	Gene names	FBXO41, FBX41, KIAA1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

FBX41_MOUSE
θ value	θ > 10 (rank : 1772)	NC score	0.058066 (rank : 1878)
Query Neighborhood Hits	1580	Target Neighborhood Hits	430	Shared Neighborhood Hits	184
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

FCRL2_HUMAN
θ value	θ > 10 (rank : 1773)	NC score	0.099535 (rank : 1446)
Query Neighborhood Hits	1580	Target Neighborhood Hits	251	Shared Neighborhood Hits	161
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

FCRL5_HUMAN
θ value	θ > 10 (rank : 1774)	NC score	0.103100 (rank : 1419)
Query Neighborhood Hits	1580	Target Neighborhood Hits	267	Shared Neighborhood Hits	177
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

FINC_HUMAN
θ value	θ > 10 (rank : 1775)	NC score	0.071915 (rank : 1698)
Query Neighborhood Hits	1580	Target Neighborhood Hits	302	Shared Neighborhood Hits	131
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

FINC_MOUSE
θ value	θ > 10 (rank : 1776)	NC score	0.073829 (rank : 1673)
Query Neighborhood Hits	1580	Target Neighborhood Hits	309	Shared Neighborhood Hits	132
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

FLNA_HUMAN
θ value	θ > 10 (rank : 1777)	NC score	0.057443 (rank : 1892)
Query Neighborhood Hits	1580	Target Neighborhood Hits	138	Shared Neighborhood Hits	37
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

FLNA_MOUSE
θ value	θ > 10 (rank : 1778)	NC score	0.057407 (rank : 1893)
Query Neighborhood Hits	1580	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

FLNB_HUMAN
θ value	θ > 10 (rank : 1779)	NC score	0.057972 (rank : 1880)
Query Neighborhood Hits	1580	Target Neighborhood Hits	111	Shared Neighborhood Hits	41
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

FLNC_HUMAN
θ value	θ > 10 (rank : 1780)	NC score	0.060212 (rank : 1842)
Query Neighborhood Hits	1580	Target Neighborhood Hits	116	Shared Neighborhood Hits	42
SwissProt Accessions	Q14315, O95303, Q07985, Q9NS12, Q9NYE5, Q9UMR8, Q9Y503	Gene names	FLNC, ABPL, FLN2
Domain Architecture
Description	Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc) (Actin-binding- like protein) (ABP-L) (ABP-280-like protein).

FNBP2_HUMAN
θ value	θ > 10 (rank : 1781)	NC score	0.053313 (rank : 1963)
Query Neighborhood Hits	1580	Target Neighborhood Hits	432	Shared Neighborhood Hits	178
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FNDC3_HUMAN
θ value	θ > 10 (rank : 1782)	NC score	0.119930 (rank : 1291)
Query Neighborhood Hits	1580	Target Neighborhood Hits	196	Shared Neighborhood Hits	113
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_MOUSE
θ value	θ > 10 (rank : 1783)	NC score	0.120024 (rank : 1290)
Query Neighborhood Hits	1580	Target Neighborhood Hits	207	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

GAS8_HUMAN
θ value	θ > 10 (rank : 1784)	NC score	0.126688 (rank : 1241)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	294
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GAS8_MOUSE
θ value	θ > 10 (rank : 1785)	NC score	0.120747 (rank : 1283)
Query Neighborhood Hits	1580	Target Neighborhood Hits	622	Shared Neighborhood Hits	256
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GBP4_HUMAN
θ value	θ > 10 (rank : 1786)	NC score	0.061250 (rank : 1825)
Query Neighborhood Hits	1580	Target Neighborhood Hits	484	Shared Neighborhood Hits	201
SwissProt Accessions	Q96PP9, Q86T99	Gene names	GBP4
Domain Architecture
Description	Guanylate-binding protein 4 (GTP-binding protein 4) (Guanine nucleotide-binding protein 4) (GBP-4).

GCC1_MOUSE
θ value	θ > 10 (rank : 1787)	NC score	0.117195 (rank : 1318)
Query Neighborhood Hits	1580	Target Neighborhood Hits	777	Shared Neighborhood Hits	285
SwissProt Accessions	Q9D4H2, Q8CCR3	Gene names	Gcc1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

GCP60_HUMAN
θ value	θ > 10 (rank : 1788)	NC score	0.061580 (rank : 1818)
Query Neighborhood Hits	1580	Target Neighborhood Hits	419	Shared Neighborhood Hits	169
SwissProt Accessions	Q9H3P7, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3	Gene names	ACBD3, GCP60
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

GCP60_MOUSE
θ value	θ > 10 (rank : 1789)	NC score	0.059128 (rank : 1861)
Query Neighborhood Hits	1580	Target Neighborhood Hits	395	Shared Neighborhood Hits	162
SwissProt Accessions	Q8BMP6, O35371	Gene names	Acbd3, Gcp60, Pap7
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

GFAP_HUMAN
θ value	θ > 10 (rank : 1790)	NC score	0.058742 (rank : 1868)
Query Neighborhood Hits	1580	Target Neighborhood Hits	723	Shared Neighborhood Hits	283
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

GFAP_MOUSE
θ value	θ > 10 (rank : 1791)	NC score	0.054561 (rank : 1940)
Query Neighborhood Hits	1580	Target Neighborhood Hits	725	Shared Neighborhood Hits	270
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

GLE1_HUMAN
θ value	θ > 10 (rank : 1792)	NC score	0.070250 (rank : 1714)
Query Neighborhood Hits	1580	Target Neighborhood Hits	445	Shared Neighborhood Hits	185
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

GLE1_MOUSE
θ value	θ > 10 (rank : 1793)	NC score	0.076728 (rank : 1643)
Query Neighborhood Hits	1580	Target Neighborhood Hits	504	Shared Neighborhood Hits	204
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

GNRP_HUMAN
θ value	θ > 10 (rank : 1794)	NC score	0.111032 (rank : 1367)
Query Neighborhood Hits	1580	Target Neighborhood Hits	239	Shared Neighborhood Hits	112
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 1795)	NC score	0.117227 (rank : 1317)
Query Neighborhood Hits	1580	Target Neighborhood Hits	191	Shared Neighborhood Hits	91
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GO45_HUMAN
θ value	θ > 10 (rank : 1796)	NC score	0.056891 (rank : 1900)
Query Neighborhood Hits	1580	Target Neighborhood Hits	189	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H2G9, O15298, Q5T531, Q9GZX4	Gene names	BLZF1, JEM1
Domain Architecture	No domain graphic available
Description	Golgin 45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor).

GP73_HUMAN
θ value	θ > 10 (rank : 1797)	NC score	0.075855 (rank : 1651)
Query Neighborhood Hits	1580	Target Neighborhood Hits	309	Shared Neighborhood Hits	163
SwissProt Accessions	Q8NBJ4, Q6IAF4, Q9NRB9	Gene names	GOLPH2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

GP73_MOUSE
θ value	θ > 10 (rank : 1798)	NC score	0.088551 (rank : 1530)
Query Neighborhood Hits	1580	Target Neighborhood Hits	506	Shared Neighborhood Hits	211
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

GPS2_HUMAN
θ value	θ > 10 (rank : 1799)	NC score	0.055000 (rank : 1927)
Query Neighborhood Hits	1580	Target Neighborhood Hits	459	Shared Neighborhood Hits	151
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

GRAP2_MOUSE
θ value	θ > 10 (rank : 1800)	NC score	0.121347 (rank : 1278)
Query Neighborhood Hits	1580	Target Neighborhood Hits	297	Shared Neighborhood Hits	107
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB14_HUMAN
θ value	θ > 10 (rank : 1801)	NC score	0.051751 (rank : 1987)
Query Neighborhood Hits	1580	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 1802)	NC score	0.056348 (rank : 1908)
Query Neighborhood Hits	1580	Target Neighborhood Hits	149	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB2_HUMAN
θ value	θ > 10 (rank : 1803)	NC score	0.125315 (rank : 1253)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	108
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 1804)	NC score	0.125155 (rank : 1255)
Query Neighborhood Hits	1580	Target Neighborhood Hits	312	Shared Neighborhood Hits	108
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 1805)	NC score	0.114189 (rank : 1343)
Query Neighborhood Hits	1580	Target Neighborhood Hits	131	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

GUC2C_HUMAN
θ value	θ > 10 (rank : 1806)	NC score	0.440263 (rank : 823)
Query Neighborhood Hits	1580	Target Neighborhood Hits	624	Shared Neighborhood Hits	572
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

HAP1_HUMAN
θ value	θ > 10 (rank : 1807)	NC score	0.093326 (rank : 1493)
Query Neighborhood Hits	1580	Target Neighborhood Hits	606	Shared Neighborhood Hits	254
SwissProt Accessions	P54257, O75358, Q9H4G3, Q9HA98, Q9NY90	Gene names	HAP1, HLP1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1).

HAP1_MOUSE
θ value	θ > 10 (rank : 1808)	NC score	0.064139 (rank : 1782)
Query Neighborhood Hits	1580	Target Neighborhood Hits	388	Shared Neighborhood Hits	188
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

HCFC2_MOUSE
θ value	θ > 10 (rank : 1809)	NC score	0.055536 (rank : 1918)
Query Neighborhood Hits	1580	Target Neighborhood Hits	97	Shared Neighborhood Hits	79
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

HCLS1_HUMAN
θ value	θ > 10 (rank : 1810)	NC score	0.060755 (rank : 1833)
Query Neighborhood Hits	1580	Target Neighborhood Hits	358	Shared Neighborhood Hits	108
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 1811)	NC score	0.062971 (rank : 1793)
Query Neighborhood Hits	1580	Target Neighborhood Hits	329	Shared Neighborhood Hits	109
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HIP1R_HUMAN
θ value	θ > 10 (rank : 1812)	NC score	0.102521 (rank : 1427)
Query Neighborhood Hits	1580	Target Neighborhood Hits	809	Shared Neighborhood Hits	288
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

HIP1_HUMAN
θ value	θ > 10 (rank : 1813)	NC score	0.112257 (rank : 1356)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1016	Shared Neighborhood Hits	316
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

HOME1_HUMAN
θ value	θ > 10 (rank : 1814)	NC score	0.077738 (rank : 1636)
Query Neighborhood Hits	1580	Target Neighborhood Hits	564	Shared Neighborhood Hits	230
SwissProt Accessions	Q86YM7, O96003, Q86YM5	Gene names	HOMER1, SYN47
Domain Architecture
Description	Homer protein homolog 1.

HOME1_MOUSE
θ value	θ > 10 (rank : 1815)	NC score	0.082776 (rank : 1595)
Query Neighborhood Hits	1580	Target Neighborhood Hits	630	Shared Neighborhood Hits	246
SwissProt Accessions	Q9Z2Y3, Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216	Gene names	Homer1, Vesl1
Domain Architecture
Description	Homer protein homolog 1 (VASP/Ena-related gene up-regulated during seizure and LTP) (Vesl-1).

HOME2_HUMAN
θ value	θ > 10 (rank : 1816)	NC score	0.081041 (rank : 1609)
Query Neighborhood Hits	1580	Target Neighborhood Hits	532	Shared Neighborhood Hits	230
SwissProt Accessions	Q9NSB8, O95269, O95349, Q9NSB6, Q9NSB7, Q9UNT7	Gene names	HOMER2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin).

HOME2_MOUSE
θ value	θ > 10 (rank : 1817)	NC score	0.098287 (rank : 1455)
Query Neighborhood Hits	1580	Target Neighborhood Hits	882	Shared Neighborhood Hits	292
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

HOOK2_HUMAN
θ value	θ > 10 (rank : 1818)	NC score	0.127685 (rank : 1229)
Query Neighborhood Hits	1580	Target Neighborhood Hits	714	Shared Neighborhood Hits	277
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

HOOK2_MOUSE
θ value	θ > 10 (rank : 1819)	NC score	0.132068 (rank : 1193)
Query Neighborhood Hits	1580	Target Neighborhood Hits	736	Shared Neighborhood Hits	294
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

HSH2D_HUMAN
θ value	θ > 10 (rank : 1820)	NC score	0.056740 (rank : 1902)
Query Neighborhood Hits	1580	Target Neighborhood Hits	159	Shared Neighborhood Hits	54
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IASPP_HUMAN
θ value	θ > 10 (rank : 1821)	NC score	0.050118 (rank : 2019)
Query Neighborhood Hits	1580	Target Neighborhood Hits	688	Shared Neighborhood Hits	141
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IDLC_HUMAN
θ value	θ > 10 (rank : 1822)	NC score	0.062570 (rank : 1803)
Query Neighborhood Hits	1580	Target Neighborhood Hits	348	Shared Neighborhood Hits	169
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

IDLC_MOUSE
θ value	θ > 10 (rank : 1823)	NC score	0.058891 (rank : 1864)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	156
SwissProt Accessions	Q8BVN8	Gene names	Dnali1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal).

IF2P_HUMAN
θ value	θ > 10 (rank : 1824)	NC score	0.090138 (rank : 1518)
Query Neighborhood Hits	1580	Target Neighborhood Hits	889	Shared Neighborhood Hits	248
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

IF3A_HUMAN
θ value	θ > 10 (rank : 1825)	NC score	0.114874 (rank : 1339)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	293
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IF3A_MOUSE
θ value	θ > 10 (rank : 1826)	NC score	0.116063 (rank : 1328)
Query Neighborhood Hits	1580	Target Neighborhood Hits	871	Shared Neighborhood Hits	288
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

IFT74_HUMAN
θ value	θ > 10 (rank : 1827)	NC score	0.134201 (rank : 1173)
Query Neighborhood Hits	1580	Target Neighborhood Hits	949	Shared Neighborhood Hits	313
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

IL1R1_HUMAN
θ value	θ > 10 (rank : 1828)	NC score	0.053463 (rank : 1959)
Query Neighborhood Hits	1580	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

IL1R2_HUMAN
θ value	θ > 10 (rank : 1829)	NC score	0.073024 (rank : 1685)
Query Neighborhood Hits	1580	Target Neighborhood Hits	153	Shared Neighborhood Hits	112
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

IL1R2_MOUSE
θ value	θ > 10 (rank : 1830)	NC score	0.059467 (rank : 1852)
Query Neighborhood Hits	1580	Target Neighborhood Hits	125	Shared Neighborhood Hits	91
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

IL6RB_HUMAN
θ value	θ > 10 (rank : 1831)	NC score	0.066777 (rank : 1752)
Query Neighborhood Hits	1580	Target Neighborhood Hits	181	Shared Neighborhood Hits	88
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

IL6RB_MOUSE
θ value	θ > 10 (rank : 1832)	NC score	0.053133 (rank : 1965)
Query Neighborhood Hits	1580	Target Neighborhood Hits	168	Shared Neighborhood Hits	88
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

IMMT_HUMAN
θ value	θ > 10 (rank : 1833)	NC score	0.088169 (rank : 1536)
Query Neighborhood Hits	1580	Target Neighborhood Hits	494	Shared Neighborhood Hits	218
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

IMMT_MOUSE
θ value	θ > 10 (rank : 1834)	NC score	0.062411 (rank : 1805)
Query Neighborhood Hits	1580	Target Neighborhood Hits	326	Shared Neighborhood Hits	160
SwissProt Accessions	Q8CAQ8, Q66JS4, Q7TNE2, Q8C7V1, Q8CCI0, Q8CDA8, Q9D9F6	Gene names	Immt
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin).

INCE_HUMAN
θ value	θ > 10 (rank : 1835)	NC score	0.124994 (rank : 1256)
Query Neighborhood Hits	1580	Target Neighborhood Hits	978	Shared Neighborhood Hits	302
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

INCE_MOUSE
θ value	θ > 10 (rank : 1836)	NC score	0.124358 (rank : 1259)
Query Neighborhood Hits	1580	Target Neighborhood Hits	903	Shared Neighborhood Hits	295
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

INVO_MOUSE
θ value	θ > 10 (rank : 1837)	NC score	0.096320 (rank : 1472)
Query Neighborhood Hits	1580	Target Neighborhood Hits	474	Shared Neighborhood Hits	196
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

IRPL1_HUMAN
θ value	θ > 10 (rank : 1838)	NC score	0.059860 (rank : 1847)
Query Neighborhood Hits	1580	Target Neighborhood Hits	196	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

IRPL1_MOUSE
θ value	θ > 10 (rank : 1839)	NC score	0.061824 (rank : 1814)
Query Neighborhood Hits	1580	Target Neighborhood Hits	186	Shared Neighborhood Hits	135
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

IRPL2_HUMAN
θ value	θ > 10 (rank : 1840)	NC score	0.064390 (rank : 1777)
Query Neighborhood Hits	1580	Target Neighborhood Hits	194	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

IRPL2_MOUSE
θ value	θ > 10 (rank : 1841)	NC score	0.063411 (rank : 1788)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	128
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

ITB4_HUMAN
θ value	θ > 10 (rank : 1842)	NC score	0.059845 (rank : 1848)
Query Neighborhood Hits	1580	Target Neighborhood Hits	458	Shared Neighborhood Hits	124
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

JAM2_HUMAN
θ value	θ > 10 (rank : 1843)	NC score	0.128072 (rank : 1225)
Query Neighborhood Hits	1580	Target Neighborhood Hits	304	Shared Neighborhood Hits	217
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

JAM2_MOUSE
θ value	θ > 10 (rank : 1844)	NC score	0.121644 (rank : 1273)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	207
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

JIP3_HUMAN
θ value	θ > 10 (rank : 1845)	NC score	0.075090 (rank : 1658)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1039	Shared Neighborhood Hits	311
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

JIP3_MOUSE
θ value	θ > 10 (rank : 1846)	NC score	0.080645 (rank : 1612)
Query Neighborhood Hits	1580	Target Neighborhood Hits	759	Shared Neighborhood Hits	293
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

JIP4_HUMAN
θ value	θ > 10 (rank : 1847)	NC score	0.055172 (rank : 1923)
Query Neighborhood Hits	1580	Target Neighborhood Hits	585	Shared Neighborhood Hits	226
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

JIP4_MOUSE
θ value	θ > 10 (rank : 1848)	NC score	0.051588 (rank : 1988)
Query Neighborhood Hits	1580	Target Neighborhood Hits	593	Shared Neighborhood Hits	232
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

K0494_HUMAN
θ value	θ > 10 (rank : 1849)	NC score	0.066718 (rank : 1755)
Query Neighborhood Hits	1580	Target Neighborhood Hits	230	Shared Neighborhood Hits	126
SwissProt Accessions	O75071	Gene names	KIAA0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

K0494_MOUSE
θ value	θ > 10 (rank : 1850)	NC score	0.060585 (rank : 1837)
Query Neighborhood Hits	1580	Target Neighborhood Hits	241	Shared Neighborhood Hits	133
SwissProt Accessions	Q8BGQ6, Q3TQN6, Q8BJV7, Q8C0R1	Gene names	Kiaa0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

K0552_HUMAN
θ value	θ > 10 (rank : 1851)	NC score	0.082856 (rank : 1589)
Query Neighborhood Hits	1580	Target Neighborhood Hits	442	Shared Neighborhood Hits	203
SwissProt Accessions	O60299	Gene names	KIAA0552
Domain Architecture
Description	Protein KIAA0552.

K0586_HUMAN
θ value	θ > 10 (rank : 1852)	NC score	0.077925 (rank : 1634)
Query Neighborhood Hits	1580	Target Neighborhood Hits	311	Shared Neighborhood Hits	149
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

K0831_MOUSE
θ value	θ > 10 (rank : 1853)	NC score	0.054804 (rank : 1933)
Query Neighborhood Hits	1580	Target Neighborhood Hits	277	Shared Neighborhood Hits	143
SwissProt Accessions	Q8CDJ3, Q69ZY1, Q6PFY6, Q8C6N0, Q8R3M3	Gene names	Kiaa0831, D14Ertd436e
Domain Architecture	No domain graphic available
Description	Protein KIAA0831.

K2C1_HUMAN
θ value	θ > 10 (rank : 1854)	NC score	0.050380 (rank : 2013)
Query Neighborhood Hits	1580	Target Neighborhood Hits	624	Shared Neighborhood Hits	239
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

KALM_HUMAN
θ value	θ > 10 (rank : 1855)	NC score	0.059191 (rank : 1859)
Query Neighborhood Hits	1580	Target Neighborhood Hits	114	Shared Neighborhood Hits	59
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

KIF11_HUMAN
θ value	θ > 10 (rank : 1856)	NC score	0.062071 (rank : 1808)
Query Neighborhood Hits	1580	Target Neighborhood Hits	583	Shared Neighborhood Hits	243
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

KIF14_HUMAN
θ value	θ > 10 (rank : 1857)	NC score	0.050033 (rank : 2021)
Query Neighborhood Hits	1580	Target Neighborhood Hits	732	Shared Neighborhood Hits	273
SwissProt Accessions	Q15058	Gene names	KIF14, KIAA0042
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF14.

KIF23_HUMAN
θ value	θ > 10 (rank : 1858)	NC score	0.058112 (rank : 1876)
Query Neighborhood Hits	1580	Target Neighborhood Hits	618	Shared Neighborhood Hits	248
SwissProt Accessions	Q02241	Gene names	KIF23, KNSL5, MKLP1
Domain Architecture
Description	Kinesin-like protein KIF23 (Mitotic kinesin-like protein 1) (Kinesin- like protein 5).

KIF3A_HUMAN
θ value	θ > 10 (rank : 1859)	NC score	0.056163 (rank : 1911)
Query Neighborhood Hits	1580	Target Neighborhood Hits	704	Shared Neighborhood Hits	265
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

KIF4A_MOUSE
θ value	θ > 10 (rank : 1860)	NC score	0.087034 (rank : 1544)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1033	Shared Neighborhood Hits	316
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF5A_HUMAN
θ value	θ > 10 (rank : 1861)	NC score	0.077088 (rank : 1641)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	297
SwissProt Accessions	Q12840, Q4LE26	Gene names	KIF5A, NKHC1
Domain Architecture
Description	Kinesin heavy chain isoform 5A (Neuronal kinesin heavy chain) (NKHC) (Kinesin heavy chain neuron-specific 1).

KIF5A_MOUSE
θ value	θ > 10 (rank : 1862)	NC score	0.076622 (rank : 1644)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	301
SwissProt Accessions	P33175, Q5DTP1, Q6PDY7, Q9Z2F9	Gene names	Kif5a, Kiaa4086, Kif5, Nkhc1
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5A (Neuronal kinesin heavy chain) (NKHC) (Kinesin heavy chain neuron-specific 1).

KIFC1_HUMAN
θ value	θ > 10 (rank : 1863)	NC score	0.054275 (rank : 1944)
Query Neighborhood Hits	1580	Target Neighborhood Hits	545	Shared Neighborhood Hits	238
SwissProt Accessions	Q9BW19, O60887, Q14834, Q9UQP7	Gene names	KIFC1, HSET, KNSL2
Domain Architecture
Description	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET).

KIFC3_HUMAN
θ value	θ > 10 (rank : 1864)	NC score	0.058517 (rank : 1871)
Query Neighborhood Hits	1580	Target Neighborhood Hits	619	Shared Neighborhood Hits	259
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KIFC3_MOUSE
θ value	θ > 10 (rank : 1865)	NC score	0.056668 (rank : 1904)
Query Neighborhood Hits	1580	Target Neighborhood Hits	571	Shared Neighborhood Hits	247
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

KINH_HUMAN
θ value	θ > 10 (rank : 1866)	NC score	0.100551 (rank : 1439)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1231	Shared Neighborhood Hits	347
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

KINH_MOUSE
θ value	θ > 10 (rank : 1867)	NC score	0.094073 (rank : 1487)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1082	Shared Neighborhood Hits	339
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

KIRR2_HUMAN
θ value	θ > 10 (rank : 1868)	NC score	0.133043 (rank : 1185)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	201
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

KIRR2_MOUSE
θ value	θ > 10 (rank : 1869)	NC score	0.132274 (rank : 1190)
Query Neighborhood Hits	1580	Target Neighborhood Hits	326	Shared Neighborhood Hits	204
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

KMHN1_HUMAN
θ value	θ > 10 (rank : 1870)	NC score	0.128171 (rank : 1224)
Query Neighborhood Hits	1580	Target Neighborhood Hits	950	Shared Neighborhood Hits	308
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

KMHN1_MOUSE
θ value	θ > 10 (rank : 1871)	NC score	0.124010 (rank : 1260)
Query Neighborhood Hits	1580	Target Neighborhood Hits	949	Shared Neighborhood Hits	310
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

KNTC2_HUMAN
θ value	θ > 10 (rank : 1872)	NC score	0.110744 (rank : 1369)
Query Neighborhood Hits	1580	Target Neighborhood Hits	673	Shared Neighborhood Hits	266
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

KNTC2_MOUSE
θ value	θ > 10 (rank : 1873)	NC score	0.115373 (rank : 1334)
Query Neighborhood Hits	1580	Target Neighborhood Hits	692	Shared Neighborhood Hits	269
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

LAMA2_HUMAN
θ value	θ > 10 (rank : 1874)	NC score	0.061427 (rank : 1823)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1092	Shared Neighborhood Hits	273
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LAMA3_HUMAN
θ value	θ > 10 (rank : 1875)	NC score	0.065766 (rank : 1764)
Query Neighborhood Hits	1580	Target Neighborhood Hits	760	Shared Neighborhood Hits	238
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

LAMA3_MOUSE
θ value	θ > 10 (rank : 1876)	NC score	0.050848 (rank : 2002)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	239
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

LAMB1_HUMAN
θ value	θ > 10 (rank : 1877)	NC score	0.058936 (rank : 1863)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1018	Shared Neighborhood Hits	282
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMC1_MOUSE
θ value	θ > 10 (rank : 1878)	NC score	0.055055 (rank : 1925)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	259
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

LBN_HUMAN
θ value	θ > 10 (rank : 1879)	NC score	0.083945 (rank : 1577)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	181
SwissProt Accessions	Q86UK5, Q86YT3, Q86YT4, Q8NG49	Gene names	EVC2, LBN
Domain Architecture	No domain graphic available
Description	Limbin.

LBN_MOUSE
θ value	θ > 10 (rank : 1880)	NC score	0.076889 (rank : 1642)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K1G2, Q8BRF3	Gene names	Evc2, Lbn
Domain Architecture	No domain graphic available
Description	Limbin.

LIPA2_HUMAN
θ value	θ > 10 (rank : 1881)	NC score	0.120358 (rank : 1288)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1044	Shared Neighborhood Hits	323
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

LIPA3_HUMAN
θ value	θ > 10 (rank : 1882)	NC score	0.099943 (rank : 1442)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	295
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPA3_MOUSE
θ value	θ > 10 (rank : 1883)	NC score	0.087223 (rank : 1542)
Query Neighborhood Hits	1580	Target Neighborhood Hits	636	Shared Neighborhood Hits	263
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

LIPB1_HUMAN
θ value	θ > 10 (rank : 1884)	NC score	0.092858 (rank : 1499)
Query Neighborhood Hits	1580	Target Neighborhood Hits	640	Shared Neighborhood Hits	260
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

LIPB1_MOUSE
θ value	θ > 10 (rank : 1885)	NC score	0.093141 (rank : 1494)
Query Neighborhood Hits	1580	Target Neighborhood Hits	727	Shared Neighborhood Hits	281
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

LMNA_HUMAN
θ value	θ > 10 (rank : 1886)	NC score	0.069305 (rank : 1723)
Query Neighborhood Hits	1580	Target Neighborhood Hits	653	Shared Neighborhood Hits	269
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

LMNA_MOUSE
θ value	θ > 10 (rank : 1887)	NC score	0.069061 (rank : 1729)
Query Neighborhood Hits	1580	Target Neighborhood Hits	661	Shared Neighborhood Hits	274
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

LMNB2_HUMAN
θ value	θ > 10 (rank : 1888)	NC score	0.071525 (rank : 1700)
Query Neighborhood Hits	1580	Target Neighborhood Hits	723	Shared Neighborhood Hits	265
SwissProt Accessions	Q03252, O75292, Q14734, Q96DF6	Gene names	LMNB2, LMN2
Domain Architecture
Description	Lamin-B2.

LMNB2_MOUSE
θ value	θ > 10 (rank : 1889)	NC score	0.066048 (rank : 1759)
Query Neighborhood Hits	1580	Target Neighborhood Hits	674	Shared Neighborhood Hits	255
SwissProt Accessions	P21619, P48680, Q8CGB1	Gene names	Lmnb2
Domain Architecture
Description	Lamin-B2.

LMO7_HUMAN
θ value	θ > 10 (rank : 1890)	NC score	0.051928 (rank : 1983)
Query Neighborhood Hits	1580	Target Neighborhood Hits	507	Shared Neighborhood Hits	155
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

LNK_HUMAN
θ value	θ > 10 (rank : 1891)	NC score	0.051795 (rank : 1985)
Query Neighborhood Hits	1580	Target Neighborhood Hits	151	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LRC27_HUMAN
θ value	θ > 10 (rank : 1892)	NC score	0.054919 (rank : 1930)
Query Neighborhood Hits	1580	Target Neighborhood Hits	710	Shared Neighborhood Hits	220
SwissProt Accessions	Q9C0I9, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21	Gene names	LRRC27, KIAA1674
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

LRC45_HUMAN
θ value	θ > 10 (rank : 1893)	NC score	0.125414 (rank : 1252)
Query Neighborhood Hits	1580	Target Neighborhood Hits	933	Shared Neighborhood Hits	319
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRC45_MOUSE
θ value	θ > 10 (rank : 1894)	NC score	0.122576 (rank : 1270)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	307
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

LRRF1_HUMAN
θ value	θ > 10 (rank : 1895)	NC score	0.070376 (rank : 1712)
Query Neighborhood Hits	1580	Target Neighborhood Hits	625	Shared Neighborhood Hits	210
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

LRRF2_HUMAN
θ value	θ > 10 (rank : 1896)	NC score	0.111635 (rank : 1361)
Query Neighborhood Hits	1580	Target Neighborhood Hits	791	Shared Neighborhood Hits	287
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LRRF2_MOUSE
θ value	θ > 10 (rank : 1897)	NC score	0.105769 (rank : 1404)
Query Neighborhood Hits	1580	Target Neighborhood Hits	556	Shared Neighborhood Hits	250
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LUZP1_HUMAN
θ value	θ > 10 (rank : 1898)	NC score	0.117861 (rank : 1310)
Query Neighborhood Hits	1580	Target Neighborhood Hits	739	Shared Neighborhood Hits	269
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

LU_HUMAN
θ value	θ > 10 (rank : 1899)	NC score	0.138426 (rank : 1137)
Query Neighborhood Hits	1580	Target Neighborhood Hits	283	Shared Neighborhood Hits	206
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

LZTS1_HUMAN
θ value	θ > 10 (rank : 1900)	NC score	0.092961 (rank : 1498)
Query Neighborhood Hits	1580	Target Neighborhood Hits	532	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2	Gene names	LZTS1, FEZ1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

LZTS1_MOUSE
θ value	θ > 10 (rank : 1901)	NC score	0.096215 (rank : 1474)
Query Neighborhood Hits	1580	Target Neighborhood Hits	540	Shared Neighborhood Hits	239
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

LZTS2_HUMAN
θ value	θ > 10 (rank : 1902)	NC score	0.084393 (rank : 1571)
Query Neighborhood Hits	1580	Target Neighborhood Hits	427	Shared Neighborhood Hits	207
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

LZTS2_MOUSE
θ value	θ > 10 (rank : 1903)	NC score	0.079236 (rank : 1618)
Query Neighborhood Hits	1580	Target Neighborhood Hits	423	Shared Neighborhood Hits	195
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

MACOI_HUMAN
θ value	θ > 10 (rank : 1904)	NC score	0.102121 (rank : 1428)
Query Neighborhood Hits	1580	Target Neighborhood Hits	650	Shared Neighborhood Hits	250
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

MACOI_MOUSE
θ value	θ > 10 (rank : 1905)	NC score	0.103454 (rank : 1417)
Query Neighborhood Hits	1580	Target Neighborhood Hits	620	Shared Neighborhood Hits	251
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

MALT1_HUMAN
θ value	θ > 10 (rank : 1906)	NC score	0.132279 (rank : 1189)
Query Neighborhood Hits	1580	Target Neighborhood Hits	236	Shared Neighborhood Hits	178
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

MAP1B_MOUSE
θ value	θ > 10 (rank : 1907)	NC score	0.061678 (rank : 1817)
Query Neighborhood Hits	1580	Target Neighborhood Hits	977	Shared Neighborhood Hits	254
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

MAP9_HUMAN
θ value	θ > 10 (rank : 1908)	NC score	0.075195 (rank : 1657)
Query Neighborhood Hits	1580	Target Neighborhood Hits	518	Shared Neighborhood Hits	189
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

MAP9_MOUSE
θ value	θ > 10 (rank : 1909)	NC score	0.076564 (rank : 1648)
Query Neighborhood Hits	1580	Target Neighborhood Hits	529	Shared Neighborhood Hits	206
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

MERL_HUMAN
θ value	θ > 10 (rank : 1910)	NC score	0.059130 (rank : 1860)
Query Neighborhood Hits	1580	Target Neighborhood Hits	532	Shared Neighborhood Hits	225
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

MERL_MOUSE
θ value	θ > 10 (rank : 1911)	NC score	0.059209 (rank : 1858)
Query Neighborhood Hits	1580	Target Neighborhood Hits	524	Shared Neighborhood Hits	223
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

MERTK_HUMAN
θ value	θ > 10 (rank : 1912)	NC score	0.605581 (rank : 752)
Query Neighborhood Hits	1580	Target Neighborhood Hits	988	Shared Neighborhood Hits	871
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MFAP1_HUMAN
θ value	θ > 10 (rank : 1913)	NC score	0.073587 (rank : 1678)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	148
SwissProt Accessions	P55081	Gene names	MFAP1
Domain Architecture
Description	Microfibrillar-associated protein 1.

MFAP1_MOUSE
θ value	θ > 10 (rank : 1914)	NC score	0.084250 (rank : 1574)
Query Neighborhood Hits	1580	Target Neighborhood Hits	353	Shared Neighborhood Hits	159
SwissProt Accessions	Q9CQU1, Q3TU29, Q8CCL1, Q9CSJ5	Gene names	Mfap1
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 1.

MICA1_HUMAN
θ value	θ > 10 (rank : 1915)	NC score	0.051335 (rank : 1993)
Query Neighborhood Hits	1580	Target Neighborhood Hits	279	Shared Neighborhood Hits	106
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MICA1_MOUSE
θ value	θ > 10 (rank : 1916)	NC score	0.072597 (rank : 1688)
Query Neighborhood Hits	1580	Target Neighborhood Hits	400	Shared Neighborhood Hits	187
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

MICA2_HUMAN
θ value	θ > 10 (rank : 1917)	NC score	0.050627 (rank : 2008)
Query Neighborhood Hits	1580	Target Neighborhood Hits	174	Shared Neighborhood Hits	38
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

MICA3_HUMAN
θ value	θ > 10 (rank : 1918)	NC score	0.050303 (rank : 2015)
Query Neighborhood Hits	1580	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

MICA3_MOUSE
θ value	θ > 10 (rank : 1919)	NC score	0.052347 (rank : 1979)
Query Neighborhood Hits	1580	Target Neighborhood Hits	104	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CJ19, Q80TE8, Q8BXB1	Gene names	Mical3, Kiaa1364
Domain Architecture
Description	Protein MICAL-3.

MILK1_HUMAN
θ value	θ > 10 (rank : 1920)	NC score	0.078087 (rank : 1632)
Query Neighborhood Hits	1580	Target Neighborhood Hits	427	Shared Neighborhood Hits	120
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MILK2_HUMAN
θ value	θ > 10 (rank : 1921)	NC score	0.085372 (rank : 1557)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	148
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

MIPO1_HUMAN
θ value	θ > 10 (rank : 1922)	NC score	0.107628 (rank : 1390)
Query Neighborhood Hits	1580	Target Neighborhood Hits	486	Shared Neighborhood Hits	242
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

MLKL_MOUSE
θ value	θ > 10 (rank : 1923)	NC score	0.608789 (rank : 750)
Query Neighborhood Hits	1580	Target Neighborhood Hits	707	Shared Neighborhood Hits	681
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

MMRN2_HUMAN
θ value	θ > 10 (rank : 1924)	NC score	0.087260 (rank : 1541)
Query Neighborhood Hits	1580	Target Neighborhood Hits	400	Shared Neighborhood Hits	182
SwissProt Accessions	Q9H8L6, Q6P2N2	Gene names	MMRN2, EMILIN3
Domain Architecture
Description	Multimerin-2 precursor (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit).

MPP10_HUMAN
θ value	θ > 10 (rank : 1925)	NC score	0.055175 (rank : 1922)
Query Neighborhood Hits	1580	Target Neighborhood Hits	306	Shared Neighborhood Hits	135
SwissProt Accessions	O00566	Gene names	MPHOSPH10, MPP10
Domain Architecture
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

MPP9_HUMAN
θ value	θ > 10 (rank : 1926)	NC score	0.115879 (rank : 1331)
Query Neighborhood Hits	1580	Target Neighborhood Hits	529	Shared Neighborhood Hits	243
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

MRIP_HUMAN
θ value	θ > 10 (rank : 1927)	NC score	0.083073 (rank : 1586)
Query Neighborhood Hits	1580	Target Neighborhood Hits	578	Shared Neighborhood Hits	232
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

MRIP_MOUSE
θ value	θ > 10 (rank : 1928)	NC score	0.082976 (rank : 1588)
Query Neighborhood Hits	1580	Target Neighborhood Hits	569	Shared Neighborhood Hits	231
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

MUC18_HUMAN
θ value	θ > 10 (rank : 1929)	NC score	0.119761 (rank : 1292)
Query Neighborhood Hits	1580	Target Neighborhood Hits	275	Shared Neighborhood Hits	192
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

MUC18_MOUSE
θ value	θ > 10 (rank : 1930)	NC score	0.119015 (rank : 1301)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	192
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

MY18B_HUMAN
θ value	θ > 10 (rank : 1931)	NC score	0.131424 (rank : 1201)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1299	Shared Neighborhood Hits	363
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

MYO15_MOUSE
θ value	θ > 10 (rank : 1932)	NC score	0.058206 (rank : 1875)
Query Neighborhood Hits	1580	Target Neighborhood Hits	467	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYO1A_HUMAN
θ value	θ > 10 (rank : 1933)	NC score	0.053280 (rank : 1964)
Query Neighborhood Hits	1580	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

MYO1B_HUMAN
θ value	θ > 10 (rank : 1934)	NC score	0.053319 (rank : 1962)
Query Neighborhood Hits	1580	Target Neighborhood Hits	70	Shared Neighborhood Hits	33
SwissProt Accessions	O43795, O43794, Q7Z6L5	Gene names	MYO1B
Domain Architecture	No domain graphic available
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).

MYO1B_MOUSE
θ value	θ > 10 (rank : 1935)	NC score	0.053064 (rank : 1966)
Query Neighborhood Hits	1580	Target Neighborhood Hits	71	Shared Neighborhood Hits	31
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

MYO1C_HUMAN
θ value	θ > 10 (rank : 1936)	NC score	0.053631 (rank : 1954)
Query Neighborhood Hits	1580	Target Neighborhood Hits	65	Shared Neighborhood Hits	28
SwissProt Accessions	O00159	Gene names	MYO1C
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMI-beta) (MMIb).

MYO1C_MOUSE
θ value	θ > 10 (rank : 1937)	NC score	0.053649 (rank : 1953)
Query Neighborhood Hits	1580	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WTI7, O08571, O08834, Q9QW54	Gene names	Myo1c
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMIb).

MYO1D_HUMAN
θ value	θ > 10 (rank : 1938)	NC score	0.053938 (rank : 1949)
Query Neighborhood Hits	1580	Target Neighborhood Hits	56	Shared Neighborhood Hits	28
SwissProt Accessions	O94832, Q8NHP9	Gene names	MYO1D, KIAA0727
Domain Architecture
Description	Myosin Id.

MYO1D_MOUSE
θ value	θ > 10 (rank : 1939)	NC score	0.053987 (rank : 1948)
Query Neighborhood Hits	1580	Target Neighborhood Hits	57	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SYD0, Q5SSK7, Q8BWY5	Gene names	Myo1d
Domain Architecture	No domain graphic available
Description	Myosin Id.

MYO1E_HUMAN
θ value	θ > 10 (rank : 1940)	NC score	0.078105 (rank : 1631)
Query Neighborhood Hits	1580	Target Neighborhood Hits	293	Shared Neighborhood Hits	122
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 1941)	NC score	0.078211 (rank : 1629)
Query Neighborhood Hits	1580	Target Neighborhood Hits	275	Shared Neighborhood Hits	122
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 1942)	NC score	0.077669 (rank : 1638)
Query Neighborhood Hits	1580	Target Neighborhood Hits	262	Shared Neighborhood Hits	114
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO5A_HUMAN
θ value	θ > 10 (rank : 1943)	NC score	0.110234 (rank : 1376)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1092	Shared Neighborhood Hits	321
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

MYO5A_MOUSE
θ value	θ > 10 (rank : 1944)	NC score	0.107652 (rank : 1389)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1117	Shared Neighborhood Hits	314
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5B_HUMAN
θ value	θ > 10 (rank : 1945)	NC score	0.099184 (rank : 1450)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	295
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

MYO6_HUMAN
θ value	θ > 10 (rank : 1946)	NC score	0.088170 (rank : 1535)
Query Neighborhood Hits	1580	Target Neighborhood Hits	727	Shared Neighborhood Hits	263
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO6_MOUSE
θ value	θ > 10 (rank : 1947)	NC score	0.084153 (rank : 1575)
Query Neighborhood Hits	1580	Target Neighborhood Hits	586	Shared Neighborhood Hits	229
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

MYO7A_HUMAN
θ value	θ > 10 (rank : 1948)	NC score	0.057617 (rank : 1886)
Query Neighborhood Hits	1580	Target Neighborhood Hits	209	Shared Neighborhood Hits	81
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO7A_MOUSE
θ value	θ > 10 (rank : 1949)	NC score	0.059511 (rank : 1851)
Query Neighborhood Hits	1580	Target Neighborhood Hits	235	Shared Neighborhood Hits	96
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

MYO9B_HUMAN
θ value	θ > 10 (rank : 1950)	NC score	0.070693 (rank : 1706)
Query Neighborhood Hits	1580	Target Neighborhood Hits	641	Shared Neighborhood Hits	159
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_MOUSE
θ value	θ > 10 (rank : 1951)	NC score	0.068553 (rank : 1733)
Query Neighborhood Hits	1580	Target Neighborhood Hits	311	Shared Neighborhood Hits	108
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NAF1_HUMAN
θ value	θ > 10 (rank : 1952)	NC score	0.110516 (rank : 1372)
Query Neighborhood Hits	1580	Target Neighborhood Hits	937	Shared Neighborhood Hits	307
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NAF1_MOUSE
θ value	θ > 10 (rank : 1953)	NC score	0.113083 (rank : 1353)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	302
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

NCF1_HUMAN
θ value	θ > 10 (rank : 1954)	NC score	0.084702 (rank : 1565)
Query Neighborhood Hits	1580	Target Neighborhood Hits	198	Shared Neighborhood Hits	84
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 1955)	NC score	0.079923 (rank : 1615)
Query Neighborhood Hits	1580	Target Neighborhood Hits	198	Shared Neighborhood Hits	83
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 1956)	NC score	0.073533 (rank : 1679)
Query Neighborhood Hits	1580	Target Neighborhood Hits	229	Shared Neighborhood Hits	86
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 1957)	NC score	0.051328 (rank : 1994)
Query Neighborhood Hits	1580	Target Neighborhood Hits	161	Shared Neighborhood Hits	52
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 1958)	NC score	0.056788 (rank : 1901)
Query Neighborhood Hits	1580	Target Neighborhood Hits	177	Shared Neighborhood Hits	66
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NDE1_HUMAN
θ value	θ > 10 (rank : 1959)	NC score	0.108067 (rank : 1385)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	301
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

NDE1_MOUSE
θ value	θ > 10 (rank : 1960)	NC score	0.093448 (rank : 1491)
Query Neighborhood Hits	1580	Target Neighborhood Hits	602	Shared Neighborhood Hits	252
SwissProt Accessions	Q9CZA6, Q3UBS6, Q3UIC1, Q9ERR0	Gene names	Nde1, Nude
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE) (mNudE).

NDEL1_HUMAN
θ value	θ > 10 (rank : 1961)	NC score	0.077658 (rank : 1639)
Query Neighborhood Hits	1580	Target Neighborhood Hits	415	Shared Neighborhood Hits	202
SwissProt Accessions	Q9GZM8, Q86T80, Q8TAR7, Q9UH50	Gene names	NDEL1, EOPA, MITAP1, NUDEL
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin- associated protein 1).

NDEL1_MOUSE
θ value	θ > 10 (rank : 1962)	NC score	0.077169 (rank : 1640)
Query Neighborhood Hits	1580	Target Neighborhood Hits	420	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ERR1, Q9D0Q4, Q9EPT6	Gene names	Ndel1, Nudel
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Protein mNudE-like) (mNudE-L).

NEB1_HUMAN
θ value	θ > 10 (rank : 1963)	NC score	0.069825 (rank : 1718)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	269
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

NEB2_HUMAN
θ value	θ > 10 (rank : 1964)	NC score	0.082382 (rank : 1600)
Query Neighborhood Hits	1580	Target Neighborhood Hits	883	Shared Neighborhood Hits	290
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEB2_MOUSE
θ value	θ > 10 (rank : 1965)	NC score	0.085473 (rank : 1556)
Query Neighborhood Hits	1580	Target Neighborhood Hits	889	Shared Neighborhood Hits	296
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

NEBL_HUMAN
θ value	θ > 10 (rank : 1966)	NC score	0.087363 (rank : 1540)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	202
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NEMO_MOUSE
θ value	θ > 10 (rank : 1967)	NC score	0.123425 (rank : 1265)
Query Neighborhood Hits	1580	Target Neighborhood Hits	658	Shared Neighborhood Hits	278
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

NEST_HUMAN
θ value	θ > 10 (rank : 1968)	NC score	0.098727 (rank : 1453)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1305	Shared Neighborhood Hits	337
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

NFM_HUMAN
θ value	θ > 10 (rank : 1969)	NC score	0.070518 (rank : 1710)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1328	Shared Neighborhood Hits	353
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

NFM_MOUSE
θ value	θ > 10 (rank : 1970)	NC score	0.068472 (rank : 1734)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1159	Shared Neighborhood Hits	327
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

NOP14_HUMAN
θ value	θ > 10 (rank : 1971)	NC score	0.054732 (rank : 1937)
Query Neighborhood Hits	1580	Target Neighborhood Hits	573	Shared Neighborhood Hits	193
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

NTBP1_MOUSE
θ value	θ > 10 (rank : 1972)	NC score	0.070674 (rank : 1708)
Query Neighborhood Hits	1580	Target Neighborhood Hits	528	Shared Neighborhood Hits	200
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

NTKL_HUMAN
θ value	θ > 10 (rank : 1973)	NC score	0.264970 (rank : 851)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	226
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

NTKL_MOUSE
θ value	θ > 10 (rank : 1974)	NC score	0.344969 (rank : 842)
Query Neighborhood Hits	1580	Target Neighborhood Hits	326	Shared Neighborhood Hits	294
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

NUCB1_MOUSE
θ value	θ > 10 (rank : 1975)	NC score	0.060861 (rank : 1830)
Query Neighborhood Hits	1580	Target Neighborhood Hits	414	Shared Neighborhood Hits	183
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

NUF2_HUMAN
θ value	θ > 10 (rank : 1976)	NC score	0.114462 (rank : 1341)
Query Neighborhood Hits	1580	Target Neighborhood Hits	661	Shared Neighborhood Hits	259
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

NUF2_MOUSE
θ value	θ > 10 (rank : 1977)	NC score	0.112548 (rank : 1355)
Query Neighborhood Hits	1580	Target Neighborhood Hits	585	Shared Neighborhood Hits	257
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

NUP88_HUMAN
θ value	θ > 10 (rank : 1978)	NC score	0.064201 (rank : 1781)
Query Neighborhood Hits	1580	Target Neighborhood Hits	354	Shared Neighborhood Hits	183
SwissProt Accessions	Q99567, Q9BWE5	Gene names	NUP88
Domain Architecture	No domain graphic available
Description	Nuclear pore complex protein Nup88 (Nucleoporin Nup88) (88 kDa nuclear pore complex protein).

OLR1_MOUSE
θ value	θ > 10 (rank : 1979)	NC score	0.072670 (rank : 1686)
Query Neighborhood Hits	1580	Target Neighborhood Hits	596	Shared Neighborhood Hits	225
SwissProt Accessions	Q9EQ09	Gene names	Olr1, Lox1
Domain Architecture	No domain graphic available
Description	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-type oxidized LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (Lectin-like oxLDL receptor 1) (LOX-1) [Contains: Oxidized low-density lipoprotein receptor 1, soluble form].

OPTN_HUMAN
θ value	θ > 10 (rank : 1980)	NC score	0.113597 (rank : 1349)
Query Neighborhood Hits	1580	Target Neighborhood Hits	827	Shared Neighborhood Hits	285
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

OSTF1_HUMAN
θ value	θ > 10 (rank : 1981)	NC score	0.070878 (rank : 1704)
Query Neighborhood Hits	1580	Target Neighborhood Hits	466	Shared Neighborhood Hits	106
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 1982)	NC score	0.066954 (rank : 1749)
Query Neighborhood Hits	1580	Target Neighborhood Hits	467	Shared Neighborhood Hits	106
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 1983)	NC score	0.094082 (rank : 1486)
Query Neighborhood Hits	1580	Target Neighborhood Hits	451	Shared Neighborhood Hits	215
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 1984)	NC score	0.093087 (rank : 1495)
Query Neighborhood Hits	1580	Target Neighborhood Hits	401	Shared Neighborhood Hits	192
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_HUMAN
θ value	θ > 10 (rank : 1985)	NC score	0.075526 (rank : 1654)
Query Neighborhood Hits	1580	Target Neighborhood Hits	479	Shared Neighborhood Hits	198
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 1986)	NC score	0.069099 (rank : 1727)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	170
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85B_HUMAN
θ value	θ > 10 (rank : 1987)	NC score	0.099183 (rank : 1451)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	239
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
θ value	θ > 10 (rank : 1988)	NC score	0.099697 (rank : 1444)
Query Neighborhood Hits	1580	Target Neighborhood Hits	519	Shared Neighborhood Hits	232
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PACE1_HUMAN
θ value	θ > 10 (rank : 1989)	NC score	0.063098 (rank : 1792)
Query Neighborhood Hits	1580	Target Neighborhood Hits	74	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PACE1_MOUSE
θ value	θ > 10 (rank : 1990)	NC score	0.063937 (rank : 1784)
Query Neighborhood Hits	1580	Target Neighborhood Hits	92	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PACN1_HUMAN
θ value	θ > 10 (rank : 1991)	NC score	0.064871 (rank : 1773)
Query Neighborhood Hits	1580	Target Neighborhood Hits	320	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 1992)	NC score	0.057503 (rank : 1890)
Query Neighborhood Hits	1580	Target Neighborhood Hits	283	Shared Neighborhood Hits	123
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 1993)	NC score	0.067953 (rank : 1739)
Query Neighborhood Hits	1580	Target Neighborhood Hits	339	Shared Neighborhood Hits	163
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 1994)	NC score	0.067922 (rank : 1740)
Query Neighborhood Hits	1580	Target Neighborhood Hits	382	Shared Neighborhood Hits	174
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 1995)	NC score	0.066496 (rank : 1757)
Query Neighborhood Hits	1580	Target Neighborhood Hits	385	Shared Neighborhood Hits	186
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 1996)	NC score	0.061447 (rank : 1820)
Query Neighborhood Hits	1580	Target Neighborhood Hits	380	Shared Neighborhood Hits	186
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PCQAP_MOUSE
θ value	θ > 10 (rank : 1997)	NC score	0.059751 (rank : 1849)
Query Neighborhood Hits	1580	Target Neighborhood Hits	506	Shared Neighborhood Hits	162
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PDL1_HUMAN
θ value	θ > 10 (rank : 1998)	NC score	0.051468 (rank : 1991)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

PDZD8_HUMAN
θ value	θ > 10 (rank : 1999)	NC score	0.086906 (rank : 1546)
Query Neighborhood Hits	1580	Target Neighborhood Hits	185	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PECA1_MOUSE
θ value	θ > 10 (rank : 2000)	NC score	0.053034 (rank : 1967)
Query Neighborhood Hits	1580	Target Neighborhood Hits	126	Shared Neighborhood Hits	86
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

PEPL_HUMAN
θ value	θ > 10 (rank : 2001)	NC score	0.144605 (rank : 1085)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1141	Shared Neighborhood Hits	337
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

PEPL_MOUSE
θ value	θ > 10 (rank : 2002)	NC score	0.144055 (rank : 1089)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1105	Shared Neighborhood Hits	336
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PGFRL_MOUSE
θ value	θ > 10 (rank : 2003)	NC score	0.070675 (rank : 1707)
Query Neighborhood Hits	1580	Target Neighborhood Hits	106	Shared Neighborhood Hits	93
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

PHLB1_HUMAN
θ value	θ > 10 (rank : 2004)	NC score	0.090001 (rank : 1521)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1038	Shared Neighborhood Hits	330
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB1_MOUSE
θ value	θ > 10 (rank : 2005)	NC score	0.069070 (rank : 1728)
Query Neighborhood Hits	1580	Target Neighborhood Hits	678	Shared Neighborhood Hits	242
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PHLB3_HUMAN
θ value	θ > 10 (rank : 2006)	NC score	0.082774 (rank : 1596)
Query Neighborhood Hits	1580	Target Neighborhood Hits	304	Shared Neighborhood Hits	165
SwissProt Accessions	Q6NSJ2, Q8N7Z4	Gene names	PHLDB3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 3.

PI3R4_HUMAN
θ value	θ > 10 (rank : 2007)	NC score	0.346678 (rank : 841)
Query Neighborhood Hits	1580	Target Neighborhood Hits	534	Shared Neighborhood Hits	347
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

PI3R4_MOUSE
θ value	θ > 10 (rank : 2008)	NC score	0.359673 (rank : 840)
Query Neighborhood Hits	1580	Target Neighborhood Hits	535	Shared Neighborhood Hits	352
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PIGR_HUMAN
θ value	θ > 10 (rank : 2009)	NC score	0.050004 (rank : 2023)
Query Neighborhood Hits	1580	Target Neighborhood Hits	164	Shared Neighborhood Hits	88
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

PIGR_MOUSE
θ value	θ > 10 (rank : 2010)	NC score	0.056530 (rank : 1906)
Query Neighborhood Hits	1580	Target Neighborhood Hits	214	Shared Neighborhood Hits	119
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

PININ_HUMAN
θ value	θ > 10 (rank : 2011)	NC score	0.099187 (rank : 1449)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	261
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PININ_MOUSE
θ value	θ > 10 (rank : 2012)	NC score	0.092559 (rank : 1500)
Query Neighborhood Hits	1580	Target Neighborhood Hits	777	Shared Neighborhood Hits	259
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

PKHA5_HUMAN
θ value	θ > 10 (rank : 2013)	NC score	0.058541 (rank : 1870)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	163
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 2014)	NC score	0.054641 (rank : 1939)
Query Neighborhood Hits	1580	Target Neighborhood Hits	556	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 2015)	NC score	0.061439 (rank : 1822)
Query Neighborhood Hits	1580	Target Neighborhood Hits	591	Shared Neighborhood Hits	190
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHF2_HUMAN
θ value	θ > 10 (rank : 2016)	NC score	0.064359 (rank : 1778)
Query Neighborhood Hits	1580	Target Neighborhood Hits	75	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 2017)	NC score	0.064097 (rank : 1783)
Query Neighborhood Hits	1580	Target Neighborhood Hits	77	Shared Neighborhood Hits	27
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PLCB2_HUMAN
θ value	θ > 10 (rank : 2018)	NC score	0.057617 (rank : 1887)
Query Neighborhood Hits	1580	Target Neighborhood Hits	608	Shared Neighborhood Hits	240
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLCB4_HUMAN
θ value	θ > 10 (rank : 2019)	NC score	0.086516 (rank : 1549)
Query Neighborhood Hits	1580	Target Neighborhood Hits	658	Shared Neighborhood Hits	254
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PLCG1_HUMAN
θ value	θ > 10 (rank : 2020)	NC score	0.082515 (rank : 1599)
Query Neighborhood Hits	1580	Target Neighborhood Hits	293	Shared Neighborhood Hits	103
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 2021)	NC score	0.083676 (rank : 1581)
Query Neighborhood Hits	1580	Target Neighborhood Hits	314	Shared Neighborhood Hits	106
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 2022)	NC score	0.077690 (rank : 1637)
Query Neighborhood Hits	1580	Target Neighborhood Hits	280	Shared Neighborhood Hits	90
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLVAP_HUMAN
θ value	θ > 10 (rank : 2023)	NC score	0.082221 (rank : 1602)
Query Neighborhood Hits	1580	Target Neighborhood Hits	397	Shared Neighborhood Hits	195
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

PLVAP_MOUSE
θ value	θ > 10 (rank : 2024)	NC score	0.055041 (rank : 1926)
Query Neighborhood Hits	1580	Target Neighborhood Hits	210	Shared Neighborhood Hits	124
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

POF1B_HUMAN
θ value	θ > 10 (rank : 2025)	NC score	0.099710 (rank : 1443)
Query Neighborhood Hits	1580	Target Neighborhood Hits	494	Shared Neighborhood Hits	222
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

POF1B_MOUSE
θ value	θ > 10 (rank : 2026)	NC score	0.102661 (rank : 1425)
Query Neighborhood Hits	1580	Target Neighborhood Hits	530	Shared Neighborhood Hits	236
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

PPIP1_HUMAN
θ value	θ > 10 (rank : 2027)	NC score	0.097051 (rank : 1462)
Query Neighborhood Hits	1580	Target Neighborhood Hits	389	Shared Neighborhood Hits	194
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP2_MOUSE
θ value	θ > 10 (rank : 2028)	NC score	0.050604 (rank : 2010)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	148
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PRC1_HUMAN
θ value	θ > 10 (rank : 2029)	NC score	0.075059 (rank : 1659)
Query Neighborhood Hits	1580	Target Neighborhood Hits	328	Shared Neighborhood Hits	171
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

PRC1_MOUSE
θ value	θ > 10 (rank : 2030)	NC score	0.072603 (rank : 1687)
Query Neighborhood Hits	1580	Target Neighborhood Hits	382	Shared Neighborhood Hits	190
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

PRPK_HUMAN
θ value	θ > 10 (rank : 2031)	NC score	0.142203 (rank : 1102)
Query Neighborhood Hits	1580	Target Neighborhood Hits	131	Shared Neighborhood Hits	123
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PRPK_MOUSE
θ value	θ > 10 (rank : 2032)	NC score	0.138349 (rank : 1141)
Query Neighborhood Hits	1580	Target Neighborhood Hits	139	Shared Neighborhood Hits	124
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

PSG10_HUMAN
θ value	θ > 10 (rank : 2033)	NC score	0.063328 (rank : 1789)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	162
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

PSG1_HUMAN
θ value	θ > 10 (rank : 2034)	NC score	0.067327 (rank : 1747)
Query Neighborhood Hits	1580	Target Neighborhood Hits	232	Shared Neighborhood Hits	167
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

PSG6_HUMAN
θ value	θ > 10 (rank : 2035)	NC score	0.064690 (rank : 1775)
Query Neighborhood Hits	1580	Target Neighborhood Hits	231	Shared Neighborhood Hits	163
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

PSG9_HUMAN
θ value	θ > 10 (rank : 2036)	NC score	0.062592 (rank : 1802)
Query Neighborhood Hits	1580	Target Neighborhood Hits	221	Shared Neighborhood Hits	162
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

PVRL1_HUMAN
θ value	θ > 10 (rank : 2037)	NC score	0.054238 (rank : 1945)
Query Neighborhood Hits	1580	Target Neighborhood Hits	219	Shared Neighborhood Hits	135
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

PVRL3_HUMAN
θ value	θ > 10 (rank : 2038)	NC score	0.058763 (rank : 1867)
Query Neighborhood Hits	1580	Target Neighborhood Hits	204	Shared Neighborhood Hits	125
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

PVRL3_MOUSE
θ value	θ > 10 (rank : 2039)	NC score	0.060054 (rank : 1844)
Query Neighborhood Hits	1580	Target Neighborhood Hits	212	Shared Neighborhood Hits	130
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

PXK_HUMAN
θ value	θ > 10 (rank : 2040)	NC score	0.129424 (rank : 1213)
Query Neighborhood Hits	1580	Target Neighborhood Hits	216	Shared Neighborhood Hits	140
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

PXK_MOUSE
θ value	θ > 10 (rank : 2041)	NC score	0.168466 (rank : 991)
Query Neighborhood Hits	1580	Target Neighborhood Hits	320	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

RABE2_MOUSE
θ value	θ > 10 (rank : 2042)	NC score	0.107147 (rank : 1395)
Query Neighborhood Hits	1580	Target Neighborhood Hits	598	Shared Neighborhood Hits	257
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

RADI_HUMAN
θ value	θ > 10 (rank : 2043)	NC score	0.074473 (rank : 1668)
Query Neighborhood Hits	1580	Target Neighborhood Hits	741	Shared Neighborhood Hits	264
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

RADI_MOUSE
θ value	θ > 10 (rank : 2044)	NC score	0.074146 (rank : 1670)
Query Neighborhood Hits	1580	Target Neighborhood Hits	773	Shared Neighborhood Hits	269
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

RAGE_MOUSE
θ value	θ > 10 (rank : 2045)	NC score	0.131719 (rank : 1198)
Query Neighborhood Hits	1580	Target Neighborhood Hits	295	Shared Neighborhood Hits	196
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

RAI14_MOUSE
θ value	θ > 10 (rank : 2046)	NC score	0.096789 (rank : 1468)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1505	Shared Neighborhood Hits	347
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

RASA1_HUMAN
θ value	θ > 10 (rank : 2047)	NC score	0.073714 (rank : 1676)
Query Neighborhood Hits	1580	Target Neighborhood Hits	258	Shared Neighborhood Hits	89
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RASF1_HUMAN
θ value	θ > 10 (rank : 2048)	NC score	0.065897 (rank : 1763)
Query Neighborhood Hits	1580	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

RASF1_MOUSE
θ value	θ > 10 (rank : 2049)	NC score	0.080166 (rank : 1614)
Query Neighborhood Hits	1580	Target Neighborhood Hits	74	Shared Neighborhood Hits	35
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

RASF8_HUMAN
θ value	θ > 10 (rank : 2050)	NC score	0.088091 (rank : 1537)
Query Neighborhood Hits	1580	Target Neighborhood Hits	469	Shared Neighborhood Hits	213
SwissProt Accessions	Q8NHQ8, O95647, Q5SCI2, Q76KB6	Gene names	RASSF8, C12orf2
Domain Architecture
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1).

RASF8_MOUSE
θ value	θ > 10 (rank : 2051)	NC score	0.082813 (rank : 1592)
Query Neighborhood Hits	1580	Target Neighborhood Hits	391	Shared Neighborhood Hits	188
SwissProt Accessions	Q8CJ96, Q8CCW4, Q9CU91	Gene names	Rassf8
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).

RBBP8_HUMAN
θ value	θ > 10 (rank : 2052)	NC score	0.086407 (rank : 1550)
Query Neighborhood Hits	1580	Target Neighborhood Hits	476	Shared Neighborhood Hits	215
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

RBM25_HUMAN
θ value	θ > 10 (rank : 2053)	NC score	0.103772 (rank : 1415)
Query Neighborhood Hits	1580	Target Neighborhood Hits	682	Shared Neighborhood Hits	235
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

RBNS5_MOUSE
θ value	θ > 10 (rank : 2054)	NC score	0.054735 (rank : 1936)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	117
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RBP1_HUMAN
θ value	θ > 10 (rank : 2055)	NC score	0.054373 (rank : 1942)
Query Neighborhood Hits	1580	Target Neighborhood Hits	521	Shared Neighborhood Hits	210
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RBP1_MOUSE
θ value	θ > 10 (rank : 2056)	NC score	0.051080 (rank : 1999)
Query Neighborhood Hits	1580	Target Neighborhood Hits	493	Shared Neighborhood Hits	210
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

REN3B_HUMAN
θ value	θ > 10 (rank : 2057)	NC score	0.083017 (rank : 1587)
Query Neighborhood Hits	1580	Target Neighborhood Hits	412	Shared Neighborhood Hits	165
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

RENT2_HUMAN
θ value	θ > 10 (rank : 2058)	NC score	0.067561 (rank : 1745)
Query Neighborhood Hits	1580	Target Neighborhood Hits	618	Shared Neighborhood Hits	215
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

RFIP4_HUMAN
θ value	θ > 10 (rank : 2059)	NC score	0.101452 (rank : 1434)
Query Neighborhood Hits	1580	Target Neighborhood Hits	785	Shared Neighborhood Hits	288
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RFIP4_MOUSE
θ value	θ > 10 (rank : 2060)	NC score	0.101868 (rank : 1430)
Query Neighborhood Hits	1580	Target Neighborhood Hits	708	Shared Neighborhood Hits	276
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

RILP_MOUSE
θ value	θ > 10 (rank : 2061)	NC score	0.060808 (rank : 1832)
Query Neighborhood Hits	1580	Target Neighborhood Hits	257	Shared Neighborhood Hits	142
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

RIMB1_MOUSE
θ value	θ > 10 (rank : 2062)	NC score	0.128217 (rank : 1223)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1376	Shared Neighborhood Hits	399
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 2063)	NC score	0.052874 (rank : 1969)
Query Neighborhood Hits	1580	Target Neighborhood Hits	263	Shared Neighborhood Hits	114
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 2064)	NC score	0.054781 (rank : 1934)
Query Neighborhood Hits	1580	Target Neighborhood Hits	246	Shared Neighborhood Hits	115
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RNF8_MOUSE
θ value	θ > 10 (rank : 2065)	NC score	0.050553 (rank : 2012)
Query Neighborhood Hits	1580	Target Neighborhood Hits	618	Shared Neighborhood Hits	200
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

RP1L1_HUMAN
θ value	θ > 10 (rank : 2066)	NC score	0.058818 (rank : 1866)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1072	Shared Neighborhood Hits	226
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

RUFY1_HUMAN
θ value	θ > 10 (rank : 2067)	NC score	0.125760 (rank : 1248)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	323
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

RUFY1_MOUSE
θ value	θ > 10 (rank : 2068)	NC score	0.121262 (rank : 1280)
Query Neighborhood Hits	1580	Target Neighborhood Hits	765	Shared Neighborhood Hits	298
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY2_MOUSE
θ value	θ > 10 (rank : 2069)	NC score	0.115182 (rank : 1335)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	295
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY3_HUMAN
θ value	θ > 10 (rank : 2070)	NC score	0.092286 (rank : 1504)
Query Neighborhood Hits	1580	Target Neighborhood Hits	594	Shared Neighborhood Hits	251
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 2071)	NC score	0.092256 (rank : 1505)
Query Neighborhood Hits	1580	Target Neighborhood Hits	579	Shared Neighborhood Hits	250
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SAFB2_HUMAN
θ value	θ > 10 (rank : 2072)	NC score	0.062018 (rank : 1809)
Query Neighborhood Hits	1580	Target Neighborhood Hits	720	Shared Neighborhood Hits	213
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

SAFB2_MOUSE
θ value	θ > 10 (rank : 2073)	NC score	0.050929 (rank : 2001)
Query Neighborhood Hits	1580	Target Neighborhood Hits	581	Shared Neighborhood Hits	196
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

SDPR_MOUSE
θ value	θ > 10 (rank : 2074)	NC score	0.062106 (rank : 1807)
Query Neighborhood Hits	1580	Target Neighborhood Hits	485	Shared Neighborhood Hits	167
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

SDS3_HUMAN
θ value	θ > 10 (rank : 2075)	NC score	0.054189 (rank : 1946)
Query Neighborhood Hits	1580	Target Neighborhood Hits	257	Shared Neighborhood Hits	120
SwissProt Accessions	Q9H7L9, Q8N6H0, Q9H8D2	Gene names	SUDS3, SDS3
Domain Architecture	No domain graphic available
Description	Sin3 histone deacetylase corepressor complex component SDS3 (Suppressor of defective silencing 3 protein homolog).

SFR12_HUMAN
θ value	θ > 10 (rank : 2076)	NC score	0.058471 (rank : 1872)
Query Neighborhood Hits	1580	Target Neighborhood Hits	553	Shared Neighborhood Hits	162
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

SH21A_HUMAN
θ value	θ > 10 (rank : 2077)	NC score	0.065491 (rank : 1765)
Query Neighborhood Hits	1580	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 2078)	NC score	0.070752 (rank : 1705)
Query Neighborhood Hits	1580	Target Neighborhood Hits	89	Shared Neighborhood Hits	42
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 2079)	NC score	0.070039 (rank : 1716)
Query Neighborhood Hits	1580	Target Neighborhood Hits	101	Shared Neighborhood Hits	44
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 2080)	NC score	0.077905 (rank : 1635)
Query Neighborhood Hits	1580	Target Neighborhood Hits	101	Shared Neighborhood Hits	44
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH24A_HUMAN
θ value	θ > 10 (rank : 2081)	NC score	0.082569 (rank : 1598)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	184
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH3G1_HUMAN
θ value	θ > 10 (rank : 2082)	NC score	0.060980 (rank : 1828)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	137
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 2083)	NC score	0.060047 (rank : 1845)
Query Neighborhood Hits	1580	Target Neighborhood Hits	291	Shared Neighborhood Hits	128
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 2084)	NC score	0.064576 (rank : 1776)
Query Neighborhood Hits	1580	Target Neighborhood Hits	324	Shared Neighborhood Hits	141
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 2085)	NC score	0.060823 (rank : 1831)
Query Neighborhood Hits	1580	Target Neighborhood Hits	319	Shared Neighborhood Hits	141
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 2086)	NC score	0.050672 (rank : 2006)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	90
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 2087)	NC score	0.057492 (rank : 1891)
Query Neighborhood Hits	1580	Target Neighborhood Hits	236	Shared Neighborhood Hits	96
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 2088)	NC score	0.078080 (rank : 1633)
Query Neighborhood Hits	1580	Target Neighborhood Hits	341	Shared Neighborhood Hits	134
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 2089)	NC score	0.075403 (rank : 1656)
Query Neighborhood Hits	1580	Target Neighborhood Hits	332	Shared Neighborhood Hits	133
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 2090)	NC score	0.058994 (rank : 1862)
Query Neighborhood Hits	1580	Target Neighborhood Hits	446	Shared Neighborhood Hits	129
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 2091)	NC score	0.050041 (rank : 2020)
Query Neighborhood Hits	1580	Target Neighborhood Hits	141	Shared Neighborhood Hits	57
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 2092)	NC score	0.052860 (rank : 1970)
Query Neighborhood Hits	1580	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_MOUSE
θ value	θ > 10 (rank : 2093)	NC score	0.050611 (rank : 2009)
Query Neighborhood Hits	1580	Target Neighborhood Hits	137	Shared Neighborhood Hits	58
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 2094)	NC score	0.061337 (rank : 1824)
Query Neighborhood Hits	1580	Target Neighborhood Hits	164	Shared Neighborhood Hits	58
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 2095)	NC score	0.062660 (rank : 1801)
Query Neighborhood Hits	1580	Target Neighborhood Hits	169	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SIGL5_HUMAN
θ value	θ > 10 (rank : 2096)	NC score	0.074966 (rank : 1662)
Query Neighborhood Hits	1580	Target Neighborhood Hits	246	Shared Neighborhood Hits	165
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

SIGL6_HUMAN
θ value	θ > 10 (rank : 2097)	NC score	0.069964 (rank : 1717)
Query Neighborhood Hits	1580	Target Neighborhood Hits	233	Shared Neighborhood Hits	166
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

SIGL7_HUMAN
θ value	θ > 10 (rank : 2098)	NC score	0.050557 (rank : 2011)
Query Neighborhood Hits	1580	Target Neighborhood Hits	180	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

SKIL_HUMAN
θ value	θ > 10 (rank : 2099)	NC score	0.071993 (rank : 1695)
Query Neighborhood Hits	1580	Target Neighborhood Hits	460	Shared Neighborhood Hits	209
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SKIL_MOUSE
θ value	θ > 10 (rank : 2100)	NC score	0.084621 (rank : 1567)
Query Neighborhood Hits	1580	Target Neighborhood Hits	719	Shared Neighborhood Hits	279
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SKI_HUMAN
θ value	θ > 10 (rank : 2101)	NC score	0.062939 (rank : 1794)
Query Neighborhood Hits	1580	Target Neighborhood Hits	423	Shared Neighborhood Hits	198
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

SKI_MOUSE
θ value	θ > 10 (rank : 2102)	NC score	0.066836 (rank : 1751)
Query Neighborhood Hits	1580	Target Neighborhood Hits	423	Shared Neighborhood Hits	191
SwissProt Accessions	Q60698, Q8VIL5	Gene names	Ski
Domain Architecture	No domain graphic available
Description	Ski oncogene (C-ski).

SLAP1_HUMAN
θ value	θ > 10 (rank : 2103)	NC score	0.111118 (rank : 1366)
Query Neighborhood Hits	1580	Target Neighborhood Hits	113	Shared Neighborhood Hits	49
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 2104)	NC score	0.109494 (rank : 1380)
Query Neighborhood Hits	1580	Target Neighborhood Hits	117	Shared Neighborhood Hits	51
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 2105)	NC score	0.120703 (rank : 1284)
Query Neighborhood Hits	1580	Target Neighborhood Hits	139	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 2106)	NC score	0.121340 (rank : 1279)
Query Neighborhood Hits	1580	Target Neighborhood Hits	136	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SMC2_MOUSE
θ value	θ > 10 (rank : 2107)	NC score	0.103023 (rank : 1420)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1131	Shared Neighborhood Hits	314
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

SMC4_HUMAN
θ value	θ > 10 (rank : 2108)	NC score	0.108503 (rank : 1382)
Query Neighborhood Hits	1580	Target Neighborhood Hits	937	Shared Neighborhood Hits	296
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

SMOO_HUMAN
θ value	θ > 10 (rank : 2109)	NC score	0.086283 (rank : 1551)
Query Neighborhood Hits	1580	Target Neighborhood Hits	391	Shared Neighborhood Hits	108
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SPAG5_HUMAN
θ value	θ > 10 (rank : 2110)	NC score	0.113792 (rank : 1347)
Query Neighborhood Hits	1580	Target Neighborhood Hits	625	Shared Neighborhood Hits	265
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

SPC24_HUMAN
θ value	θ > 10 (rank : 2111)	NC score	0.078906 (rank : 1623)
Query Neighborhood Hits	1580	Target Neighborhood Hits	324	Shared Neighborhood Hits	168
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

SPC25_HUMAN
θ value	θ > 10 (rank : 2112)	NC score	0.057119 (rank : 1897)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	148
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

SPN90_HUMAN
θ value	θ > 10 (rank : 2113)	NC score	0.056469 (rank : 1907)
Query Neighborhood Hits	1580	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SRBS1_MOUSE
θ value	θ > 10 (rank : 2114)	NC score	0.071950 (rank : 1696)
Query Neighborhood Hits	1580	Target Neighborhood Hits	409	Shared Neighborhood Hits	130
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 2115)	NC score	0.061440 (rank : 1821)
Query Neighborhood Hits	1580	Target Neighborhood Hits	269	Shared Neighborhood Hits	102
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 2116)	NC score	0.058886 (rank : 1865)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	102
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRRM1_MOUSE
θ value	θ > 10 (rank : 2117)	NC score	0.057533 (rank : 1889)
Query Neighborhood Hits	1580	Target Neighborhood Hits	966	Shared Neighborhood Hits	176
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

SRRM2_HUMAN
θ value	θ > 10 (rank : 2118)	NC score	0.055975 (rank : 1915)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1296	Shared Neighborhood Hits	217
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

SSNA1_HUMAN
θ value	θ > 10 (rank : 2119)	NC score	0.056073 (rank : 1912)
Query Neighborhood Hits	1580	Target Neighborhood Hits	175	Shared Neighborhood Hits	97
SwissProt Accessions	O43805, Q6FG70, Q9BVW8	Gene names	SSNA1, NA14
Domain Architecture
Description	Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa).

SSNA1_MOUSE
θ value	θ > 10 (rank : 2120)	NC score	0.057002 (rank : 1899)
Query Neighborhood Hits	1580	Target Neighborhood Hits	182	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JJ94	Gene names	Ssna1
Domain Architecture	No domain graphic available
Description	Sjoegren syndrome nuclear autoantigen 1 homolog.

STAC3_HUMAN
θ value	θ > 10 (rank : 2121)	NC score	0.131796 (rank : 1196)
Query Neighborhood Hits	1580	Target Neighborhood Hits	228	Shared Neighborhood Hits	109
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 2122)	NC score	0.132717 (rank : 1187)
Query Neighborhood Hits	1580	Target Neighborhood Hits	232	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 2123)	NC score	0.138804 (rank : 1135)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	126
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 2124)	NC score	0.142871 (rank : 1096)
Query Neighborhood Hits	1580	Target Neighborhood Hits	268	Shared Neighborhood Hits	120
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_MOUSE
θ value	θ > 10 (rank : 2125)	NC score	0.073645 (rank : 1677)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	103
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 2126)	NC score	0.070179 (rank : 1715)
Query Neighborhood Hits	1580	Target Neighborhood Hits	288	Shared Neighborhood Hits	116
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 2127)	NC score	0.072215 (rank : 1693)
Query Neighborhood Hits	1580	Target Neighborhood Hits	285	Shared Neighborhood Hits	108
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STIM1_MOUSE
θ value	θ > 10 (rank : 2128)	NC score	0.080192 (rank : 1613)
Query Neighborhood Hits	1580	Target Neighborhood Hits	660	Shared Neighborhood Hits	255
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

STIM2_HUMAN
θ value	θ > 10 (rank : 2129)	NC score	0.050710 (rank : 2004)
Query Neighborhood Hits	1580	Target Neighborhood Hits	420	Shared Neighborhood Hits	195
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

STMN1_HUMAN
θ value	θ > 10 (rank : 2130)	NC score	0.060383 (rank : 1839)
Query Neighborhood Hits	1580	Target Neighborhood Hits	554	Shared Neighborhood Hits	204
SwissProt Accessions	P16949	Gene names	STMN1, LAP18, OP18
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Protein Pr22).

STMN1_MOUSE
θ value	θ > 10 (rank : 2131)	NC score	0.058244 (rank : 1874)
Query Neighborhood Hits	1580	Target Neighborhood Hits	560	Shared Neighborhood Hits	203
SwissProt Accessions	P54227	Gene names	Stmn1, Lag, Lap18, Pr22
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Pr22 protein) (Leukemia-associated gene protein).

STMN2_HUMAN
θ value	θ > 10 (rank : 2132)	NC score	0.053512 (rank : 1957)
Query Neighborhood Hits	1580	Target Neighborhood Hits	458	Shared Neighborhood Hits	195
SwissProt Accessions	Q93045, O14952, Q6PK68	Gene names	STMN2, SCG10, SCGN10
Domain Architecture
Description	Stathmin-2 (SCG10 protein) (Superior cervical ganglion-10 protein).

STMN2_MOUSE
θ value	θ > 10 (rank : 2133)	NC score	0.053512 (rank : 1958)
Query Neighborhood Hits	1580	Target Neighborhood Hits	458	Shared Neighborhood Hits	195
SwissProt Accessions	P55821	Gene names	Stmn2, Scg10, Scgn10, Stmb2
Domain Architecture
Description	Stathmin-2 (SCG10 protein) (Superior cervical ganglion-10 protein).

STXB4_HUMAN
θ value	θ > 10 (rank : 2134)	NC score	0.078119 (rank : 1630)
Query Neighborhood Hits	1580	Target Neighborhood Hits	616	Shared Neighborhood Hits	222
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	θ > 10 (rank : 2135)	NC score	0.071581 (rank : 1699)
Query Neighborhood Hits	1580	Target Neighborhood Hits	629	Shared Neighborhood Hits	233
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

SURF6_MOUSE
θ value	θ > 10 (rank : 2136)	NC score	0.051139 (rank : 1996)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	104
SwissProt Accessions	P70279, Q8BPI4, Q8BRL7, Q8R0Q7	Gene names	Surf6, Surf-6
Domain Architecture
Description	Surfeit locus protein 6.

SWP70_HUMAN
θ value	θ > 10 (rank : 2137)	NC score	0.133604 (rank : 1181)
Query Neighborhood Hits	1580	Target Neighborhood Hits	973	Shared Neighborhood Hits	323
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYCP1_HUMAN
θ value	θ > 10 (rank : 2138)	NC score	0.134983 (rank : 1167)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1313	Shared Neighborhood Hits	354
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SYCP3_HUMAN
θ value	θ > 10 (rank : 2139)	NC score	0.054486 (rank : 1941)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	138
SwissProt Accessions	Q8IZU3	Gene names	SYCP3, SCP3
Domain Architecture	No domain graphic available
Description	Synaptonemal complex protein 3 (SCP-3).

T3JAM_HUMAN
θ value	θ > 10 (rank : 2140)	NC score	0.110432 (rank : 1373)
Query Neighborhood Hits	1580	Target Neighborhood Hits	533	Shared Neighborhood Hits	248
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

T3JAM_MOUSE
θ value	θ > 10 (rank : 2141)	NC score	0.106876 (rank : 1398)
Query Neighborhood Hits	1580	Target Neighborhood Hits	535	Shared Neighborhood Hits	231
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

TACC1_HUMAN
θ value	θ > 10 (rank : 2142)	NC score	0.083746 (rank : 1579)
Query Neighborhood Hits	1580	Target Neighborhood Hits	597	Shared Neighborhood Hits	248
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

TACC1_MOUSE
θ value	θ > 10 (rank : 2143)	NC score	0.084554 (rank : 1569)
Query Neighborhood Hits	1580	Target Neighborhood Hits	667	Shared Neighborhood Hits	262
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

TACC2_HUMAN
θ value	θ > 10 (rank : 2144)	NC score	0.101830 (rank : 1431)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	315
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TACC2_MOUSE
θ value	θ > 10 (rank : 2145)	NC score	0.086955 (rank : 1545)
Query Neighborhood Hits	1580	Target Neighborhood Hits	774	Shared Neighborhood Hits	292
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

TACC3_HUMAN
θ value	θ > 10 (rank : 2146)	NC score	0.081886 (rank : 1604)
Query Neighborhood Hits	1580	Target Neighborhood Hits	779	Shared Neighborhood Hits	271
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TAF7_HUMAN
θ value	θ > 10 (rank : 2147)	NC score	0.054730 (rank : 1938)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	136
SwissProt Accessions	Q15545, Q13036	Gene names	TAF7, TAF2F, TAFII55
Domain Architecture
Description	Transcription initiation factor TFIID subunit 7 (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55).

TAF7_MOUSE
θ value	θ > 10 (rank : 2148)	NC score	0.053391 (rank : 1960)
Query Neighborhood Hits	1580	Target Neighborhood Hits	217	Shared Neighborhood Hits	127
SwissProt Accessions	Q9R1C0	Gene names	Taf7, Taf2f
Domain Architecture
Description	Transcription initiation factor TFIID subunit 7 (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55).

TARSH_HUMAN
θ value	θ > 10 (rank : 2149)	NC score	0.061876 (rank : 1813)
Query Neighborhood Hits	1580	Target Neighborhood Hits	768	Shared Neighborhood Hits	159
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TAXB1_HUMAN
θ value	θ > 10 (rank : 2150)	NC score	0.121642 (rank : 1274)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	287
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

TAXB1_MOUSE
θ value	θ > 10 (rank : 2151)	NC score	0.127141 (rank : 1238)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	304
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

TEKT1_HUMAN
θ value	θ > 10 (rank : 2152)	NC score	0.076599 (rank : 1645)
Query Neighborhood Hits	1580	Target Neighborhood Hits	289	Shared Neighborhood Hits	173
SwissProt Accessions	Q969V4	Gene names	TEKT1
Domain Architecture
Description	Tektin-1.

TEKT1_MOUSE
θ value	θ > 10 (rank : 2153)	NC score	0.083681 (rank : 1580)
Query Neighborhood Hits	1580	Target Neighborhood Hits	399	Shared Neighborhood Hits	190
SwissProt Accessions	Q9DAJ2	Gene names	Tekt1
Domain Architecture
Description	Tektin-1.

TEX9_HUMAN
θ value	θ > 10 (rank : 2154)	NC score	0.099513 (rank : 1447)
Query Neighborhood Hits	1580	Target Neighborhood Hits	541	Shared Neighborhood Hits	241
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

TMCO3_HUMAN
θ value	θ > 10 (rank : 2155)	NC score	0.055254 (rank : 1921)
Query Neighborhood Hits	1580	Target Neighborhood Hits	238	Shared Neighborhood Hits	142
SwissProt Accessions	Q6UWJ1, Q5JSB1, Q6NUN1, Q8NG29, Q8TCI6, Q96EA6, Q9NWT2	Gene names	TMCO3, C13orf11
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domain-containing protein 3 precursor (Putative LAG1-interacting protein).

TMCO3_MOUSE
θ value	θ > 10 (rank : 2156)	NC score	0.051239 (rank : 1995)
Query Neighborhood Hits	1580	Target Neighborhood Hits	241	Shared Neighborhood Hits	136
SwissProt Accessions	Q8BH01, Q3UFX1, Q7TMT5, Q8BGL4, Q8R303	Gene names	Tmco3
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domain-containing protein 3 precursor.

TNI3K_HUMAN
θ value	θ > 10 (rank : 2157)	NC score	0.629286 (rank : 711)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1084	Shared Neighborhood Hits	781
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNI3K_MOUSE
θ value	θ > 10 (rank : 2158)	NC score	0.636397 (rank : 689)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1079	Shared Neighborhood Hits	776
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

TNIP3_HUMAN
θ value	θ > 10 (rank : 2159)	NC score	0.107328 (rank : 1393)
Query Neighborhood Hits	1580	Target Neighborhood Hits	511	Shared Neighborhood Hits	229
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

TNNT2_HUMAN
θ value	θ > 10 (rank : 2160)	NC score	0.076566 (rank : 1647)
Query Neighborhood Hits	1580	Target Neighborhood Hits	433	Shared Neighborhood Hits	183
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TNNT2_MOUSE
θ value	θ > 10 (rank : 2161)	NC score	0.068928 (rank : 1730)
Query Neighborhood Hits	1580	Target Neighborhood Hits	395	Shared Neighborhood Hits	181
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

TNNT3_HUMAN
θ value	θ > 10 (rank : 2162)	NC score	0.061544 (rank : 1819)
Query Neighborhood Hits	1580	Target Neighborhood Hits	327	Shared Neighborhood Hits	158
SwissProt Accessions	P45378, Q12975, Q12976, Q12977, Q12978, Q86TH6	Gene names	TNNT3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (Beta TnTF).

TNNT3_MOUSE
θ value	θ > 10 (rank : 2163)	NC score	0.063196 (rank : 1790)
Query Neighborhood Hits	1580	Target Neighborhood Hits	317	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QZ47, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46	Gene names	Tnnt3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT).

TPM1_HUMAN
θ value	θ > 10 (rank : 2164)	NC score	0.105136 (rank : 1407)
Query Neighborhood Hits	1580	Target Neighborhood Hits	716	Shared Neighborhood Hits	269
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM1_MOUSE
θ value	θ > 10 (rank : 2165)	NC score	0.107070 (rank : 1396)
Query Neighborhood Hits	1580	Target Neighborhood Hits	729	Shared Neighborhood Hits	275
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TPM2_HUMAN
θ value	θ > 10 (rank : 2166)	NC score	0.104762 (rank : 1410)
Query Neighborhood Hits	1580	Target Neighborhood Hits	677	Shared Neighborhood Hits	262
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM2_MOUSE
θ value	θ > 10 (rank : 2167)	NC score	0.104753 (rank : 1411)
Query Neighborhood Hits	1580	Target Neighborhood Hits	676	Shared Neighborhood Hits	265
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM4_HUMAN
θ value	θ > 10 (rank : 2168)	NC score	0.097338 (rank : 1459)
Query Neighborhood Hits	1580	Target Neighborhood Hits	525	Shared Neighborhood Hits	230
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

TPM4_MOUSE
θ value	θ > 10 (rank : 2169)	NC score	0.099353 (rank : 1448)
Query Neighborhood Hits	1580	Target Neighborhood Hits	703	Shared Neighborhood Hits	267
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

TRAIP_HUMAN
θ value	θ > 10 (rank : 2170)	NC score	0.096731 (rank : 1469)
Query Neighborhood Hits	1580	Target Neighborhood Hits	780	Shared Neighborhood Hits	266
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

TRAIP_MOUSE
θ value	θ > 10 (rank : 2171)	NC score	0.097588 (rank : 1458)
Query Neighborhood Hits	1580	Target Neighborhood Hits	745	Shared Neighborhood Hits	251
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

TRAK2_HUMAN
θ value	θ > 10 (rank : 2172)	NC score	0.086816 (rank : 1548)
Query Neighborhood Hits	1580	Target Neighborhood Hits	476	Shared Neighborhood Hits	229
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

TRDN_HUMAN
θ value	θ > 10 (rank : 2173)	NC score	0.062682 (rank : 1800)
Query Neighborhood Hits	1580	Target Neighborhood Hits	542	Shared Neighborhood Hits	162
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

TS101_HUMAN
θ value	θ > 10 (rank : 2174)	NC score	0.050662 (rank : 2007)
Query Neighborhood Hits	1580	Target Neighborhood Hits	359	Shared Neighborhood Hits	158
SwissProt Accessions	Q99816, Q9BUM5	Gene names	TSG101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

TTBK1_HUMAN
θ value	θ > 10 (rank : 2175)	NC score	0.655959 (rank : 658)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1058	Shared Neighborhood Hits	742
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TTBK2_HUMAN
θ value	θ > 10 (rank : 2176)	NC score	0.647404 (rank : 668)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	709
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

TTBK2_MOUSE
θ value	θ > 10 (rank : 2177)	NC score	0.644274 (rank : 676)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	702
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

TUFT1_MOUSE
θ value	θ > 10 (rank : 2178)	NC score	0.106911 (rank : 1397)
Query Neighborhood Hits	1580	Target Neighborhood Hits	732	Shared Neighborhood Hits	274
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

TXLNA_HUMAN
θ value	θ > 10 (rank : 2179)	NC score	0.107722 (rank : 1388)
Query Neighborhood Hits	1580	Target Neighborhood Hits	982	Shared Neighborhood Hits	315
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

TXLNB_HUMAN
θ value	θ > 10 (rank : 2180)	NC score	0.102696 (rank : 1424)
Query Neighborhood Hits	1580	Target Neighborhood Hits	912	Shared Neighborhood Hits	302
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

TXLNG_HUMAN
θ value	θ > 10 (rank : 2181)	NC score	0.100534 (rank : 1440)
Query Neighborhood Hits	1580	Target Neighborhood Hits	568	Shared Neighborhood Hits	242
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

TXLNG_MOUSE
θ value	θ > 10 (rank : 2182)	NC score	0.101757 (rank : 1433)
Query Neighborhood Hits	1580	Target Neighborhood Hits	552	Shared Neighborhood Hits	245
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

TYRO3_HUMAN
θ value	θ > 10 (rank : 2183)	NC score	0.633144 (rank : 697)
Query Neighborhood Hits	1580	Target Neighborhood Hits	995	Shared Neighborhood Hits	897
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

U2AFL_HUMAN
θ value	θ > 10 (rank : 2184)	NC score	0.062683 (rank : 1799)
Query Neighborhood Hits	1580	Target Neighborhood Hits	503	Shared Neighborhood Hits	202
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

U2AFM_HUMAN
θ value	θ > 10 (rank : 2185)	NC score	0.064894 (rank : 1772)
Query Neighborhood Hits	1580	Target Neighborhood Hits	577	Shared Neighborhood Hits	217
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

U2AFM_MOUSE
θ value	θ > 10 (rank : 2186)	NC score	0.061792 (rank : 1815)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	205
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

UACA_MOUSE
θ value	θ > 10 (rank : 2187)	NC score	0.117105 (rank : 1320)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1620	Shared Neighborhood Hits	370
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

UN13A_HUMAN
θ value	θ > 10 (rank : 2188)	NC score	0.085953 (rank : 1554)
Query Neighborhood Hits	1580	Target Neighborhood Hits	285	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 2189)	NC score	0.081447 (rank : 1607)
Query Neighborhood Hits	1580	Target Neighborhood Hits	217	Shared Neighborhood Hits	62
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 2190)	NC score	0.078979 (rank : 1622)
Query Neighborhood Hits	1580	Target Neighborhood Hits	210	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UNC5D_HUMAN
θ value	θ > 10 (rank : 2191)	NC score	0.059267 (rank : 1857)
Query Neighborhood Hits	1580	Target Neighborhood Hits	267	Shared Neighborhood Hits	157
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

UNC5D_MOUSE
θ value	θ > 10 (rank : 2192)	NC score	0.059927 (rank : 1846)
Query Neighborhood Hits	1580	Target Neighborhood Hits	268	Shared Neighborhood Hits	157
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

USH2A_HUMAN
θ value	θ > 10 (rank : 2193)	NC score	0.059353 (rank : 1855)
Query Neighborhood Hits	1580	Target Neighborhood Hits	600	Shared Neighborhood Hits	132
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

USH2A_MOUSE
θ value	θ > 10 (rank : 2194)	NC score	0.054978 (rank : 1929)
Query Neighborhood Hits	1580	Target Neighborhood Hits	626	Shared Neighborhood Hits	137
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

VDP_HUMAN
θ value	θ > 10 (rank : 2195)	NC score	0.105609 (rank : 1405)
Query Neighborhood Hits	1580	Target Neighborhood Hits	645	Shared Neighborhood Hits	253
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

VDP_MOUSE
θ value	θ > 10 (rank : 2196)	NC score	0.090004 (rank : 1520)
Query Neighborhood Hits	1580	Target Neighborhood Hits	469	Shared Neighborhood Hits	223
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

VIME_HUMAN
θ value	θ > 10 (rank : 2197)	NC score	0.051968 (rank : 1982)
Query Neighborhood Hits	1580	Target Neighborhood Hits	706	Shared Neighborhood Hits	277
SwissProt Accessions	P08670, Q15867, Q15868, Q15869, Q6LER9, Q8N850, Q96ML2, Q9NTM3	Gene names	VIM
Domain Architecture
Description	Vimentin.

VIME_MOUSE
θ value	θ > 10 (rank : 2198)	NC score	0.053673 (rank : 1952)
Query Neighborhood Hits	1580	Target Neighborhood Hits	716	Shared Neighborhood Hits	275
SwissProt Accessions	P20152, O08704, Q8CCH1	Gene names	Vim
Domain Architecture
Description	Vimentin.

VINEX_HUMAN
θ value	θ > 10 (rank : 2199)	NC score	0.074119 (rank : 1671)
Query Neighborhood Hits	1580	Target Neighborhood Hits	270	Shared Neighborhood Hits	100
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 2200)	NC score	0.075675 (rank : 1653)
Query Neighborhood Hits	1580	Target Neighborhood Hits	286	Shared Neighborhood Hits	103
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VRK1_HUMAN
θ value	θ > 10 (rank : 2201)	NC score	0.431474 (rank : 827)
Query Neighborhood Hits	1580	Target Neighborhood Hits	584	Shared Neighborhood Hits	563
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

VRK1_MOUSE
θ value	θ > 10 (rank : 2202)	NC score	0.435954 (rank : 825)
Query Neighborhood Hits	1580	Target Neighborhood Hits	583	Shared Neighborhood Hits	564
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

VRK2_HUMAN
θ value	θ > 10 (rank : 2203)	NC score	0.438917 (rank : 824)
Query Neighborhood Hits	1580	Target Neighborhood Hits	582	Shared Neighborhood Hits	550
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK2_MOUSE
θ value	θ > 10 (rank : 2204)	NC score	0.444339 (rank : 822)
Query Neighborhood Hits	1580	Target Neighborhood Hits	586	Shared Neighborhood Hits	563
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK3_HUMAN
θ value	θ > 10 (rank : 2205)	NC score	0.241714 (rank : 858)
Query Neighborhood Hits	1580	Target Neighborhood Hits	349	Shared Neighborhood Hits	306
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VRK3_MOUSE
θ value	θ > 10 (rank : 2206)	NC score	0.215858 (rank : 881)
Query Neighborhood Hits	1580	Target Neighborhood Hits	342	Shared Neighborhood Hits	314
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VSIG4_HUMAN
θ value	θ > 10 (rank : 2207)	NC score	0.102737 (rank : 1423)
Query Neighborhood Hits	1580	Target Neighborhood Hits	236	Shared Neighborhood Hits	164
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

WDR67_HUMAN
θ value	θ > 10 (rank : 2208)	NC score	0.086259 (rank : 1552)
Query Neighborhood Hits	1580	Target Neighborhood Hits	782	Shared Neighborhood Hits	260
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

WDR67_MOUSE
θ value	θ > 10 (rank : 2209)	NC score	0.067661 (rank : 1742)
Query Neighborhood Hits	1580	Target Neighborhood Hits	476	Shared Neighborhood Hits	176
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

WTAP_HUMAN
θ value	θ > 10 (rank : 2210)	NC score	0.057723 (rank : 1883)
Query Neighborhood Hits	1580	Target Neighborhood Hits	262	Shared Neighborhood Hits	138
SwissProt Accessions	Q15007, Q96T28, Q9BYJ7, Q9H4E2	Gene names	WTAP, KIAA0105
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

WTAP_MOUSE
θ value	θ > 10 (rank : 2211)	NC score	0.054363 (rank : 1943)
Query Neighborhood Hits	1580	Target Neighborhood Hits	250	Shared Neighborhood Hits	136
SwissProt Accessions	Q9ER69	Gene names	Wtap
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

XE7_HUMAN
θ value	θ > 10 (rank : 2212)	NC score	0.114128 (rank : 1345)
Query Neighborhood Hits	1580	Target Neighborhood Hits	738	Shared Neighborhood Hits	267
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

YO11_MOUSE
θ value	θ > 10 (rank : 2213)	NC score	0.067098 (rank : 1748)
Query Neighborhood Hits	1580	Target Neighborhood Hits	272	Shared Neighborhood Hits	133
SwissProt Accessions	P11260	Gene names
Domain Architecture
Description	Hypothetical protein ORF-1137.

ZC313_HUMAN
θ value	θ > 10 (rank : 2214)	NC score	0.076516 (rank : 1649)
Query Neighborhood Hits	1580	Target Neighborhood Hits	772	Shared Neighborhood Hits	213
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZN291_HUMAN
θ value	θ > 10 (rank : 2215)	NC score	0.122311 (rank : 1271)
Query Neighborhood Hits	1580	Target Neighborhood Hits	647	Shared Neighborhood Hits	268
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

ZRF1_HUMAN
θ value	θ > 10 (rank : 2216)	NC score	0.057650 (rank : 1885)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	172
SwissProt Accessions	Q99543	Gene names	ZRF1, DNAJC2, MPHOSPH11, MPP11
Domain Architecture
Description	Zuotin-related factor 1 (M-phase phosphoprotein 11).

ZRF1_MOUSE
θ value	θ > 10 (rank : 2217)	NC score	0.073263 (rank : 1681)
Query Neighborhood Hits	1580	Target Neighborhood Hits	414	Shared Neighborhood Hits	171
SwissProt Accessions	P54103	Gene names	Zrf1, Dnajc2
Domain Architecture
Description	Zuotin-related factor 1.

ZWINT_HUMAN
θ value	θ > 10 (rank : 2218)	NC score	0.074482 (rank : 1667)
Query Neighborhood Hits	1580	Target Neighborhood Hits	333	Shared Neighborhood Hits	174
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

ZWINT_MOUSE
θ value	θ > 10 (rank : 2219)	NC score	0.096180 (rank : 1475)
Query Neighborhood Hits	1580	Target Neighborhood Hits	497	Shared Neighborhood Hits	229
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

Hits sorted by NC score

TRIO_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1580	Shared Neighborhood Hits	1580
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

DUET_HUMAN
NC score	0.944935 (rank : 2)	θ value	2.95243e-160 (rank : 3)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1220	Shared Neighborhood Hits	1032
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

DAPK3_HUMAN
NC score	0.890046 (rank : 3)	θ value	3.36421e-55 (rank : 7)
Query Neighborhood Hits	1580	Target Neighborhood Hits	945	Shared Neighborhood Hits	853
SwissProt Accessions	O43293	Gene names	DAPK3, ZIPK
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK2_HUMAN
NC score	0.889843 (rank : 4)	θ value	2.94719e-51 (rank : 11)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	806
SwissProt Accessions	Q9UIK4, O75892	Gene names	DAPK2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

DAPK3_MOUSE
NC score	0.889559 (rank : 5)	θ value	9.45883e-58 (rank : 4)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	809
SwissProt Accessions	O54784	Gene names	Dapk3, Zipk
Domain Architecture
Description	Death-associated protein kinase 3 (EC 2.7.11.1) (DAP kinase 3) (DAP- like kinase) (Dlk) (ZIP-kinase).

DAPK2_MOUSE
NC score	0.889370 (rank : 6)	θ value	1.56274e-52 (rank : 9)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	808
SwissProt Accessions	Q8VDF3, O88861, Q9QYM4	Gene names	Dapk2
Domain Architecture
Description	Death-associated protein kinase 2 (EC 2.7.11.1) (DAP kinase 2) (DAP- kinase-related protein 1) (DRP-1).

KCC4_MOUSE
NC score	0.887331 (rank : 7)	θ value	1.46607e-42 (rank : 21)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	822
SwissProt Accessions	P08414, Q61381	Gene names	Camk4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

KCC4_HUMAN
NC score	0.886743 (rank : 8)	θ value	5.57106e-42 (rank : 22)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	804
SwissProt Accessions	Q16566	Gene names	CAMK4
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type IV (EC 2.7.11.17) (CAM kinase-GR) (CaMK IV).

ST17A_HUMAN
NC score	0.885950 (rank : 9)	θ value	5.7518e-47 (rank : 14)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	806
SwissProt Accessions	Q9UEE5, Q8IVC8	Gene names	STK17A, DRAK1
Domain Architecture
Description	Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1).

ST17B_HUMAN
NC score	0.884637 (rank : 10)	θ value	1.41672e-45 (rank : 15)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	804
SwissProt Accessions	O94768	Gene names	STK17B, DRAK2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KCC1B_HUMAN
NC score	0.884071 (rank : 11)	θ value	1.16164e-39 (rank : 24)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	808
SwissProt Accessions	Q6P2M8	Gene names	PNCK
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase).

KCC1B_MOUSE
NC score	0.883995 (rank : 12)	θ value	3.05695e-40 (rank : 23)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	808
SwissProt Accessions	Q9QYK9, Q80W07	Gene names	Pnck
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1B (EC 2.7.11.17) (CaM kinase IB) (CaM kinase I beta) (CaMKI-beta) (CaM-KI beta) (Pregnancy up-regulated non-ubiquitously expressed CaM kinase homolog).

OBSCN_HUMAN
NC score	0.883924 (rank : 13)	θ value	1.15626e-55 (rank : 6)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1931	Shared Neighborhood Hits	1117
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

KCC1D_MOUSE
NC score	0.883886 (rank : 14)	θ value	1.6774e-38 (rank : 27)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	810
SwissProt Accessions	Q8BW96, Q3U450, Q80W64, Q8BWI7	Gene names	Camk1d
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK) (mCKLiK).

KCC1D_HUMAN
NC score	0.883824 (rank : 15)	θ value	2.86122e-38 (rank : 28)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	809
SwissProt Accessions	Q8IU85, Q9HD31	Gene names	CAMK1D
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1D (EC 2.7.11.17) (CaM kinase ID) (CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI delta) (Camk1D) (CamKI-like protein kinase) (CKLiK).

ST17B_MOUSE
NC score	0.883671 (rank : 16)	θ value	1.85029e-45 (rank : 16)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	807
SwissProt Accessions	Q8BG48, Q3TNG7, Q8BLV9, Q923E7	Gene names	Stk17b, Drak2
Domain Architecture
Description	Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2).

KCC1A_MOUSE
NC score	0.883374 (rank : 17)	θ value	4.41421e-39 (rank : 25)
Query Neighborhood Hits	1580	Target Neighborhood Hits	845	Shared Neighborhood Hits	813
SwissProt Accessions	Q91YS8	Gene names	Camk1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

KPSH2_HUMAN
NC score	0.883277 (rank : 18)	θ value	1.12514e-34 (rank : 39)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	796
SwissProt Accessions	Q96QS6	Gene names	PSKH2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (PSK-H2).

DCAK3_MOUSE
NC score	0.883236 (rank : 19)	θ value	5.96599e-36 (rank : 35)
Query Neighborhood Hits	1580	Target Neighborhood Hits	922	Shared Neighborhood Hits	814
SwissProt Accessions	Q8BWQ5, Q1A748	Gene names	Dcamkl3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3) (CLICK-I and II-related) (CLr).

KCC1A_HUMAN
NC score	0.883109 (rank : 20)	θ value	1.28434e-38 (rank : 26)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	813
SwissProt Accessions	Q14012	Gene names	CAMK1
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha).

DCAK3_HUMAN
NC score	0.882906 (rank : 21)	θ value	1.20211e-36 (rank : 31)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	814
SwissProt Accessions	Q9C098	Gene names	DCAMKL3, KIAA1765
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL3 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 3).

KPSH1_HUMAN
NC score	0.882219 (rank : 22)	θ value	9.20422e-37 (rank : 30)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	804
SwissProt Accessions	P11801, Q9NY19	Gene names	PSKH1
Domain Architecture
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

KPSH1_MOUSE
NC score	0.882006 (rank : 23)	θ value	1.57e-36 (rank : 32)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	804
SwissProt Accessions	Q91YA2, Q3U3V3	Gene names	Pskh1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase H1 (EC 2.7.11.1) (PSK-H1).

MYLK2_HUMAN
NC score	0.881938 (rank : 24)	θ value	1.85459e-37 (rank : 29)
Query Neighborhood Hits	1580	Target Neighborhood Hits	920	Shared Neighborhood Hits	816
SwissProt Accessions	Q9H1R3, Q96I84	Gene names	MYLK2
Domain Architecture
Description	Myosin light chain kinase 2, skeletal/cardiac muscle (EC 2.7.11.18) (MLCK2).

KCC1G_MOUSE
NC score	0.880935 (rank : 25)	θ value	4.568e-36 (rank : 34)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	811
SwissProt Accessions	Q91VB2	Gene names	Camk1g
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC1G_HUMAN
NC score	0.880863 (rank : 26)	θ value	5.96599e-36 (rank : 36)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	810
SwissProt Accessions	Q96NX5, Q86UH5, Q9Y3J7	Gene names	CAMK1G, VWS1
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type 1G (EC 2.7.11.17) (CaM kinase IG) (CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM- KI gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III).

KCC2G_MOUSE
NC score	0.878963 (rank : 27)	θ value	8.06329e-33 (rank : 41)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	806
SwissProt Accessions	Q923T9, Q3U3H3, Q8VED3	Gene names	Camk2g
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2G_HUMAN
NC score	0.878895 (rank : 28)	θ value	8.06329e-33 (rank : 40)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	804
SwissProt Accessions	Q13555, O15378, Q13556, Q5SQZ4	Gene names	CAMK2G
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase type II gamma chain (EC 2.7.11.17) (CaM-kinase II gamma chain) (CaM kinase II gamma subunit) (CaMK-II subunit gamma).

KCC2A_MOUSE
NC score	0.878732 (rank : 29)	θ value	6.82597e-32 (rank : 46)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	800
SwissProt Accessions	P11798, Q61284	Gene names	Camk2a
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2A_HUMAN
NC score	0.878661 (rank : 30)	θ value	1.79631e-32 (rank : 43)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	801
SwissProt Accessions	Q9UQM7, Q9Y352	Gene names	CAMK2A
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II alpha chain (EC 2.7.11.17) (CaM-kinase II alpha chain) (CaM kinase II alpha subunit) (CaMK-II subunit alpha).

KCC2B_HUMAN
NC score	0.877786 (rank : 31)	θ value	2.42779e-29 (rank : 61)
Query Neighborhood Hits	1580	Target Neighborhood Hits	866	Shared Neighborhood Hits	810
SwissProt Accessions	Q13554, O95437, O95438, O95599, Q9UGH7, Q9UGH8, Q9UGH9, Q9UNX0, Q9UNX7, Q9UP00, Q9Y5N4, Q9Y6F4	Gene names	CAMK2B, CAM2, CAMKB
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

KCC2D_HUMAN
NC score	0.877760 (rank : 32)	θ value	6.82597e-32 (rank : 47)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	802
SwissProt Accessions	Q13557, Q9UGH6, Q9UQE9	Gene names	CAMK2D
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II delta chain (EC 2.7.11.17) (CaM-kinase II delta chain) (CaM kinase II subunit delta) (CaMK-II subunit delta).

CHK2_MOUSE
NC score	0.877215 (rank : 33)	θ value	5.97985e-28 (rank : 80)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	802
SwissProt Accessions	Q9Z265	Gene names	Chek2, Chk2, Rad53
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1).

CHK2_HUMAN
NC score	0.877139 (rank : 34)	θ value	2.77775e-25 (rank : 119)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	803
SwissProt Accessions	O96017, Q6QA03, Q6QA04, Q6QA05, Q6QA06, Q6QA07, Q6QA08, Q6QA10, Q6QA11, Q6QA12, Q6QA13, Q9HCQ8, Q9UGF0, Q9UGF1	Gene names	CHEK2, CHK2
Domain Architecture
Description	Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (Cds1).

SNRK_HUMAN
NC score	0.877070 (rank : 35)	θ value	7.06379e-29 (rank : 66)
Query Neighborhood Hits	1580	Target Neighborhood Hits	855	Shared Neighborhood Hits	802
SwissProt Accessions	Q9NRH2, Q14706, Q68D15, Q6IQ46, Q9NXI7	Gene names	SNRK, KIAA0096, SNFRK
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

KCC2B_MOUSE
NC score	0.876371 (rank : 36)	θ value	2.42779e-29 (rank : 62)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	802
SwissProt Accessions	P28652, Q5SVH9	Gene names	Camk2b, Camk2d
Domain Architecture
Description	Calcium/calmodulin-dependent protein kinase type II beta chain (EC 2.7.11.17) (CaM-kinase II beta chain) (CaM kinase II subunit beta) (CaMK-II subunit beta).

SNRK_MOUSE
NC score	0.875943 (rank : 37)	θ value	1.02001e-27 (rank : 89)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	798
SwissProt Accessions	Q8VDU5, Q91WX6	Gene names	Snrk
Domain Architecture	No domain graphic available
Description	SNF-related serine/threonine-protein kinase (EC 2.7.11.1) (SNF1- related kinase).

PHKG1_MOUSE
NC score	0.875719 (rank : 38)	θ value	5.06226e-27 (rank : 97)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	805
SwissProt Accessions	P07934	Gene names	Phkg1, Phkg
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_MOUSE
NC score	0.875329 (rank : 39)	θ value	2.12685e-25 (rank : 118)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	810
SwissProt Accessions	Q9DB30	Gene names	Phkg2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2).

PHKG1_HUMAN
NC score	0.875322 (rank : 40)	θ value	3.87602e-27 (rank : 95)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	806
SwissProt Accessions	Q16816	Gene names	PHKG1, PHKG
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform (EC 2.7.11.19) (Phosphorylase kinase subunit gamma 1).

PHKG2_HUMAN
NC score	0.874919 (rank : 41)	θ value	2.35151e-24 (rank : 127)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	810
SwissProt Accessions	P15735, P11800	Gene names	PHKG2
Domain Architecture
Description	Phosphorylase b kinase gamma catalytic chain, testis/liver isoform (EC 2.7.11.19) (PHK-gamma-T) (Phosphorylase kinase subunit gamma 2) (PSK-C3).

STK33_HUMAN
NC score	0.874675 (rank : 42)	θ value	6.82597e-32 (rank : 49)
Query Neighborhood Hits	1580	Target Neighborhood Hits	879	Shared Neighborhood Hits	820
SwissProt Accessions	Q9BYT3, Q658S6, Q8NEF5	Gene names	STK33
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 33 (EC 2.7.11.1).

BRSK1_HUMAN
NC score	0.874230 (rank : 43)	θ value	2.96777e-27 (rank : 94)
Query Neighborhood Hits	1580	Target Neighborhood Hits	942	Shared Neighborhood Hits	824
SwissProt Accessions	Q8TDC3, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4	Gene names	BRSK1, KIAA1811, SAD1
Domain Architecture
Description	BR serine/threonine-protein kinase 1 (EC 2.7.11.1) (SAD1 kinase) (SAD1A).

MYLK_HUMAN
NC score	0.873854 (rank : 44)	θ value	3.48949e-44 (rank : 18)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1328	Shared Neighborhood Hits	1016
SwissProt Accessions	Q15746, O95796, O95797, O95798, O95799, Q14844, Q16794, Q5MY99, Q5MYA0, Q7Z4J0, Q9C0L5, Q9UBG5, Q9UIT9	Gene names	MYLK, MLCK
Domain Architecture
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

BRSK2_HUMAN
NC score	0.873822 (rank : 45)	θ value	1.92365e-26 (rank : 109)
Query Neighborhood Hits	1580	Target Neighborhood Hits	897	Shared Neighborhood Hits	817
SwissProt Accessions	Q8IWQ3, O60843, O95099, Q5J5B4, Q8TB60	Gene names	BRSK2, C11orf7, PEN11B, STK29
Domain Architecture
Description	BR serine/threonine-protein kinase 2 (EC 2.7.11.1) (Serine/threonine- protein kinase 29) (SAD1B).

MAPK3_HUMAN
NC score	0.872519 (rank : 46)	θ value	8.36355e-22 (rank : 169)
Query Neighborhood Hits	1580	Target Neighborhood Hits	807	Shared Neighborhood Hits	781
SwissProt Accessions	Q16644	Gene names	MAPKAPK3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3) (Chromosome 3p kinase) (3pK).

MAPK2_HUMAN
NC score	0.872433 (rank : 47)	θ value	5.99374e-20 (rank : 206)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	804
SwissProt Accessions	P49137, Q8IYD6	Gene names	MAPKAPK2
Domain Architecture
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK2_MOUSE
NC score	0.872410 (rank : 48)	θ value	4.58923e-20 (rank : 201)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	802
SwissProt Accessions	P49138, Q6P561	Gene names	Mapkapk2, Rps6kc1
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 2 (EC 2.7.11.1) (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAPK-2) (MK2).

MAPK3_MOUSE
NC score	0.872310 (rank : 49)	θ value	4.9032e-22 (rank : 162)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	789
SwissProt Accessions	Q3UMW7, Q3T9E6, Q8K0G3	Gene names	Mapkapk3
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 3 (EC 2.7.11.1) (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAPK-3).

KPCD1_MOUSE
NC score	0.872073 (rank : 50)	θ value	1.16434e-31 (rank : 50)
Query Neighborhood Hits	1580	Target Neighborhood Hits	891	Shared Neighborhood Hits	816
SwissProt Accessions	Q62101	Gene names	Prkd1, Pkcm, Pkd, Prkcm
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

KPCD1_HUMAN
NC score	0.871769 (rank : 51)	θ value	6.82597e-32 (rank : 48)
Query Neighborhood Hits	1580	Target Neighborhood Hits	901	Shared Neighborhood Hits	814
SwissProt Accessions	Q15139	Gene names	PRKD1, PKD, PKD1, PRKCM
Domain Architecture
Description	Serine/threonine-protein kinase D1 (EC 2.7.11.13) (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu).

NIM1_MOUSE
NC score	0.871742 (rank : 52)	θ value	1.47289e-26 (rank : 106)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	814
SwissProt Accessions	Q8BHI9, Q8BXQ9	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

HUNK_HUMAN
NC score	0.871735 (rank : 53)	θ value	7.80994e-28 (rank : 84)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	821
SwissProt Accessions	P57058	Gene names	HUNK, MAKV
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V) (B19).

KPCD2_HUMAN
NC score	0.871731 (rank : 54)	θ value	2.34606e-32 (rank : 44)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	816
SwissProt Accessions	Q9BZL6, Q8TB08, Q9P0T6, Q9Y3X8	Gene names	PRKD2, PKD2
Domain Architecture
Description	Serine/threonine-protein kinase D2 (EC 2.7.11.13) (nPKC-D2).

HUNK_MOUSE
NC score	0.871711 (rank : 55)	θ value	4.57862e-28 (rank : 78)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	817
SwissProt Accessions	O88866	Gene names	Hunk, Makv
Domain Architecture
Description	Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (Serine/threonine-protein kinase MAK-V).

MYLK_MOUSE
NC score	0.871684 (rank : 56)	θ value	2.26182e-43 (rank : 19)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1489	Shared Neighborhood Hits	1035
SwissProt Accessions	Q6PDN3, Q3TSJ7, Q80UX0, Q80YN7, Q80YN8, Q8K026, Q924D2, Q9ERD3	Gene names	Mylk
Domain Architecture	No domain graphic available
Description	Myosin light chain kinase, smooth muscle (EC 2.7.11.18) (MLCK) (Telokin) (Kinase-related protein) (KRP).

MELK_MOUSE
NC score	0.871511 (rank : 57)	θ value	1.57365e-28 (rank : 74)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	810
SwissProt Accessions	Q61846, Q61804, Q6ZQH6	Gene names	Melk, Kiaa0175, Pk38
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38).

NUAK2_HUMAN
NC score	0.871427 (rank : 58)	θ value	1.2049e-28 (rank : 73)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	817
SwissProt Accessions	Q9H093	Gene names	NUAK2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (SNF1/AMP kinase-related kinase) (SNARK).

MELK_HUMAN
NC score	0.871419 (rank : 59)	θ value	1.02001e-27 (rank : 88)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	806
SwissProt Accessions	Q14680, Q7L3C3	Gene names	MELK, KIAA0175
Domain Architecture	No domain graphic available
Description	Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (hMELK) (Protein kinase PK38) (hPK38).

DCAK2_HUMAN
NC score	0.871160 (rank : 60)	θ value	1.79631e-32 (rank : 42)
Query Neighborhood Hits	1580	Target Neighborhood Hits	862	Shared Neighborhood Hits	808
SwissProt Accessions	Q8N568, Q8N399	Gene names	DCAMKL2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

DCAK1_HUMAN
NC score	0.870937 (rank : 61)	θ value	3.4976e-36 (rank : 33)
Query Neighborhood Hits	1580	Target Neighborhood Hits	877	Shared Neighborhood Hits	815
SwissProt Accessions	O15075	Gene names	DCAMKL1, KIAA0369
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

DCAK2_MOUSE
NC score	0.870887 (rank : 62)	θ value	3.06405e-32 (rank : 45)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	808
SwissProt Accessions	Q6PGN3, Q8BUU0, Q8BX25	Gene names	Dcamkl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase DCAMKL2 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 2).

AURKC_MOUSE
NC score	0.870774 (rank : 63)	θ value	8.93572e-24 (rank : 133)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	815
SwissProt Accessions	O88445, Q9JLC2	Gene names	Aurkc, Aie1, Stk13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 1) (Aurora-C).

KPCD3_MOUSE
NC score	0.870752 (rank : 64)	θ value	7.54701e-31 (rank : 55)
Query Neighborhood Hits	1580	Target Neighborhood Hits	901	Shared Neighborhood Hits	812
SwissProt Accessions	Q8K1Y2	Gene names	Prkd3, Prkcn
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu).

ULK3_MOUSE
NC score	0.870628 (rank : 65)	θ value	6.18819e-25 (rank : 123)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	818
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

DCAK1_MOUSE
NC score	0.870524 (rank : 66)	θ value	2.96089e-35 (rank : 38)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	812
SwissProt Accessions	Q9JLM8, Q6P207	Gene names	Dcamkl1, Dclk
Domain Architecture
Description	Serine/threonine-protein kinase DCAMKL1 (EC 2.7.11.1) (Doublecortin- like and CAM kinase-like 1).

NUAK1_MOUSE
NC score	0.870426 (rank : 67)	θ value	5.06226e-27 (rank : 96)
Query Neighborhood Hits	1580	Target Neighborhood Hits	881	Shared Neighborhood Hits	814
SwissProt Accessions	Q641K5, Q6I6D6, Q8CGE1	Gene names	Nuak1, Kiaa0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1).

NUAK2_MOUSE
NC score	0.870362 (rank : 68)	θ value	9.54697e-26 (rank : 117)
Query Neighborhood Hits	1580	Target Neighborhood Hits	878	Shared Neighborhood Hits	818
SwissProt Accessions	Q8BZN4, Q80ZW3, Q8CIC0, Q9DBV0	Gene names	Nuak2
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 2 (EC 2.7.11.1).

KPCD3_HUMAN
NC score	0.870345 (rank : 69)	θ value	1.6813e-30 (rank : 56)
Query Neighborhood Hits	1580	Target Neighborhood Hits	895	Shared Neighborhood Hits	813
SwissProt Accessions	O94806	Gene names	PRKD3, EPK2, PRKCN
Domain Architecture
Description	Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (nPKC-nu) (Protein kinase EPK2).

AAPK2_HUMAN
NC score	0.870234 (rank : 70)	θ value	3.50572e-28 (rank : 77)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	809
SwissProt Accessions	P54646, Q9H1E8, Q9UD43	Gene names	PRKAA2, AMPK, AMPK2
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1) (AMPK alpha-2 chain).

NUAK1_HUMAN
NC score	0.870107 (rank : 71)	θ value	1.73987e-27 (rank : 92)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	813
SwissProt Accessions	O60285, Q96KA8	Gene names	NUAK1, ARK5, KIAA0537
Domain Architecture	No domain graphic available
Description	NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5).

SN1L1_HUMAN
NC score	0.869997 (rank : 72)	θ value	1.85889e-29 (rank : 60)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	823
SwissProt Accessions	P57059, Q5R2V5, Q86YJ2	Gene names	SNF1LK
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK).

NIM1_HUMAN
NC score	0.869944 (rank : 73)	θ value	6.61148e-27 (rank : 103)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	813
SwissProt Accessions	Q8IY84	Gene names	NIM1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase NIM1 (EC 2.7.11.1).

AURKC_HUMAN
NC score	0.869777 (rank : 74)	θ value	3.07116e-24 (rank : 129)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UQB9, O60681, O75442, Q9UPK5	Gene names	AURKC, AIE2, AIK3, STK13
Domain Architecture
Description	Serine/threonine-protein kinase 13 (EC 2.7.11.1) (Aurora/Ipl1/Eg2 protein 2) (Aurora/Ipl1-related kinase 3) (Aurora-C).

STK6_MOUSE
NC score	0.869712 (rank : 75)	θ value	1.47289e-26 (rank : 108)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	819
SwissProt Accessions	P97477, O35624, Q91YU4	Gene names	Stk6, Ark1, Aurka, Ayk1, Iak1
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Aurora-family kinase 1) (Aurora/IPL1-related kinase 1) (Ipl1- and aurora-related kinase 1) (Aurora-A) (Serine/threonine-protein kinase Ayk1).

SN1L1_MOUSE
NC score	0.869592 (rank : 76)	θ value	2.59387e-31 (rank : 52)
Query Neighborhood Hits	1580	Target Neighborhood Hits	895	Shared Neighborhood Hits	820
SwissProt Accessions	Q60670	Gene names	Snf1lk, Msk
Domain Architecture
Description	Serine/threonine-protein kinase SNF1-like kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase SNF1LK) (HRT-20) (Myocardial SNF1- like kinase).

AURKB_MOUSE
NC score	0.869535 (rank : 77)	θ value	2.59989e-23 (rank : 143)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	816
SwissProt Accessions	O70126, Q61882	Gene names	Aurkb, Ark2, Stk1, Stk12, Stk5
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- related kinase 2) (Serine/threonine-protein kinase 5) (STK-1).

K0999_HUMAN
NC score	0.869486 (rank : 78)	θ value	2.05525e-28 (rank : 75)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	815
SwissProt Accessions	Q9Y2K2, Q59FY2, Q5M9N1, Q6P3R6, Q8IYM8, Q9HA50	Gene names	KIAA0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

ULK3_HUMAN
NC score	0.869330 (rank : 79)	θ value	1.42661e-21 (rank : 171)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	805
SwissProt Accessions	Q6PHR2, Q9NPN5, Q9UFS4	Gene names	ULK3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

STK6_HUMAN
NC score	0.869264 (rank : 80)	θ value	7.80994e-28 (rank : 85)
Query Neighborhood Hits	1580	Target Neighborhood Hits	916	Shared Neighborhood Hits	830
SwissProt Accessions	O14965, O60445, O75873, Q9BQD6, Q9UPG5	Gene names	STK6, AIK, ARK1, AURA, BTAK, STK15
Domain Architecture
Description	Serine/threonine-protein kinase 6 (EC 2.7.11.1) (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase).

K0999_MOUSE
NC score	0.869231 (rank : 81)	θ value	5.97985e-28 (rank : 81)
Query Neighborhood Hits	1580	Target Neighborhood Hits	931	Shared Neighborhood Hits	819
SwissProt Accessions	Q6P4S6, Q641L5, Q66JZ5, Q6ZQ09, Q8K075, Q9CYD5	Gene names	Kiaa0999
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase KIAA0999 (EC 2.7.11.1).

PASK_MOUSE
NC score	0.869108 (rank : 82)	θ value	3.39556e-23 (rank : 147)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	806
SwissProt Accessions	Q8CEE6, Q91YD8	Gene names	Pask, Kiaa0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN).

SN1L2_MOUSE
NC score	0.869019 (rank : 83)	θ value	1.6813e-30 (rank : 57)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	827
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

AAPK1_MOUSE
NC score	0.868998 (rank : 84)	θ value	6.61148e-27 (rank : 102)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	811
SwissProt Accessions	Q5EG47	Gene names	Prkaa1
Domain Architecture	No domain graphic available
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

AAPK1_HUMAN
NC score	0.868933 (rank : 85)	θ value	6.61148e-27 (rank : 101)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	811
SwissProt Accessions	Q13131, O00286, Q5D0E1, Q9UNQ4	Gene names	PRKAA1, AMPK1
Domain Architecture
Description	5'-AMP-activated protein kinase catalytic subunit alpha-1 (EC 2.7.11.1) (AMPK alpha-1 chain).

TSSK3_MOUSE
NC score	0.868687 (rank : 86)	θ value	7.30988e-26 (rank : 116)
Query Neighborhood Hits	1580	Target Neighborhood Hits	806	Shared Neighborhood Hits	779
SwissProt Accessions	Q9D2E1, Q9JL98	Gene names	Tssk3, Stk22c, Stk22d
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

MKNK2_MOUSE
NC score	0.868593 (rank : 87)	θ value	8.93572e-24 (rank : 135)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	792
SwissProt Accessions	Q8CDB0, O08606, Q75PY0, Q9D893	Gene names	Mknk2, Mnk2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

SN1L2_HUMAN
NC score	0.868507 (rank : 88)	θ value	1.4233e-29 (rank : 59)
Query Neighborhood Hits	1580	Target Neighborhood Hits	964	Shared Neighborhood Hits	837
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

TSSK3_HUMAN
NC score	0.868491 (rank : 89)	θ value	3.62785e-25 (rank : 121)
Query Neighborhood Hits	1580	Target Neighborhood Hits	806	Shared Neighborhood Hits	777
SwissProt Accessions	Q96PN8	Gene names	TSSK3, SPOGA3, STK22C
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 3 (EC 2.7.11.1) (TSSK- 3) (Testis-specific kinase 3) (TSK-3) (Serine/threonine-protein kinase 22C).

CAMKV_MOUSE
NC score	0.868481 (rank : 90)	θ value	7.80994e-28 (rank : 83)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	773
SwissProt Accessions	Q3UHL1, Q8VD20	Gene names	Camkv
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

AURKB_HUMAN
NC score	0.868287 (rank : 91)	θ value	8.36355e-22 (rank : 167)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	815
SwissProt Accessions	Q96GD4, O14630, O60446, O95083, Q96DV5, Q9UQ46	Gene names	AURKB, AIK2, AIM1, ARK2, STK12
Domain Architecture
Description	Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-B) (Aurora- and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1- related kinase 2) (Aurora-related kinase 2) (STK-1).

MKNK2_HUMAN
NC score	0.868285 (rank : 92)	θ value	2.20094e-22 (rank : 157)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	792
SwissProt Accessions	Q9HBH9, Q6GPI3, Q9HBH8, Q9UHR0, Q9Y2N6	Gene names	MKNK2, MNK2
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (Mnk2).

PLK4_HUMAN
NC score	0.868060 (rank : 93)	θ value	4.28545e-26 (rank : 114)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	820
SwissProt Accessions	O00444, Q8IYF0, Q96Q95	Gene names	PLK4, SAK, STK18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

TSSK1_MOUSE
NC score	0.867951 (rank : 94)	θ value	3.17815e-21 (rank : 175)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	799
SwissProt Accessions	Q61241	Gene names	Tssk1, Stk22a
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

TSSK2_HUMAN
NC score	0.867913 (rank : 95)	θ value	2.87452e-22 (rank : 160)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	797
SwissProt Accessions	Q96PF2, Q8IY55	Gene names	TSSK2, DGSG, SPOGA2, STK22B
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B) (DiGeorge syndrome protein G).

PLK4_MOUSE
NC score	0.867257 (rank : 96)	θ value	2.51237e-26 (rank : 111)
Query Neighborhood Hits	1580	Target Neighborhood Hits	879	Shared Neighborhood Hits	817
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

TSSK4_MOUSE
NC score	0.867194 (rank : 97)	θ value	1.16704e-23 (rank : 137)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	810
SwissProt Accessions	Q9D411	Gene names	Tssk4
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4).

TSSK1_HUMAN
NC score	0.867181 (rank : 98)	θ value	7.0802e-21 (rank : 185)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	792
SwissProt Accessions	Q9BXA7	Gene names	TSSK1, SPOGA1, SPOGA4, STK22A, STK22D
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 1 (EC 2.7.11.1) (TSSK- 1) (Testis-specific kinase 1) (TSK-1) (Serine/threonine-protein kinase 22A).

MARK4_MOUSE
NC score	0.866759 (rank : 99)	θ value	1.2049e-28 (rank : 72)
Query Neighborhood Hits	1580	Target Neighborhood Hits	898	Shared Neighborhood Hits	820
SwissProt Accessions	Q8CIP4, Q80T81	Gene names	Mark4, Kiaa1860
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1).

MARK4_HUMAN
NC score	0.866675 (rank : 100)	θ value	1.2049e-28 (rank : 71)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	821
SwissProt Accessions	Q96L34, Q8NG37, Q96JG7, Q96SQ2, Q9BYD8	Gene names	MARK4, KIAA1860, MARKL1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1).

PASK_HUMAN
NC score	0.866599 (rank : 101)	θ value	5.42112e-21 (rank : 182)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	796
SwissProt Accessions	Q96RG2, Q86XH6, Q99763, Q9UFR7	Gene names	PASK, KIAA0135
Domain Architecture
Description	PAS domain-containing serine/threonine-protein kinase (EC 2.7.11.1) (PAS-kinase) (PASKIN) (hPASK).

TSSK2_MOUSE
NC score	0.866340 (rank : 102)	θ value	9.24701e-21 (rank : 190)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	788
SwissProt Accessions	O54863	Gene names	Tssk2, Stk22b
Domain Architecture
Description	Testis-specific serine/threonine-protein kinase 2 (EC 2.7.11.1) (TSSK- 2) (Testis-specific kinase 2) (TSK-2) (Serine/threonine-protein kinase 22B).

TSSK4_HUMAN
NC score	0.865901 (rank : 103)	θ value	7.0802e-21 (rank : 186)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	808
SwissProt Accessions	Q6SA08	Gene names	TSSK4, C14orf20, STK22E
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 4 (EC 2.7.11.1) (TSSK- 4) (Testis-specific kinase 4) (TSK-4) (Serine/threonine-protein kinase 22E).

SBK1_MOUSE
NC score	0.865882 (rank : 104)	θ value	1.47631e-18 (rank : 245)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	786
SwissProt Accessions	Q8QZX0	Gene names	Sbk1, Sbk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

SBK1_HUMAN
NC score	0.865677 (rank : 105)	θ value	2.5182e-18 (rank : 254)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	789
SwissProt Accessions	Q52WX2	Gene names	SBK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SBK1 (EC 2.7.11.1) (SH3-binding kinase 1).

TSSK6_MOUSE
NC score	0.865492 (rank : 106)	θ value	5.06226e-27 (rank : 99)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	799
SwissProt Accessions	Q925K9, Q5RL09, Q8C625	Gene names	Tssk6, Sstk
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

KKCC2_HUMAN
NC score	0.865462 (rank : 107)	θ value	7.82807e-20 (rank : 207)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	810
SwissProt Accessions	Q96RR4, O94883, Q8IUG2, Q8IUG3, Q8N3I4, Q8WY03, Q8WY04, Q8WY05, Q8WY06, Q96RP1, Q96RP2, Q96RR3, Q9BWE9, Q9UER3, Q9UES2, Q9Y5N2	Gene names	CAMKK2, CAMKKB, KIAA0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

MARK3_MOUSE
NC score	0.865391 (rank : 108)	θ value	1.08979e-29 (rank : 58)
Query Neighborhood Hits	1580	Target Neighborhood Hits	919	Shared Neighborhood Hits	816
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

KKCC2_MOUSE
NC score	0.865324 (rank : 109)	θ value	7.82807e-20 (rank : 208)
Query Neighborhood Hits	1580	Target Neighborhood Hits	855	Shared Neighborhood Hits	810
SwissProt Accessions	Q8C078, Q80TS0, Q8BXM8, Q8C0G3, Q8CH42, Q8QZT7	Gene names	Camkk2, Kiaa0787
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 2 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase beta) (CaM-kinase kinase beta) (CaM-KK beta) (CaMKK beta).

PDPK1_HUMAN
NC score	0.865300 (rank : 110)	θ value	3.28125e-26 (rank : 112)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	809
SwissProt Accessions	O15530	Gene names	PDPK1, PDK1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (hPDK1).

MARK1_MOUSE
NC score	0.865211 (rank : 111)	θ value	1.2049e-28 (rank : 70)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	815
SwissProt Accessions	Q8VHJ5, Q69ZI7	Gene names	Mark1, Emk3, Kiaa1477
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1) (ELKL motif serine/threonine-protein kinase 3).

TSSK6_HUMAN
NC score	0.865033 (rank : 112)	θ value	4.28545e-26 (rank : 115)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	800
SwissProt Accessions	Q9BXA6, Q6ZMC4, Q96LJ4	Gene names	TSSK6, FKSG82, SSTK
Domain Architecture	No domain graphic available
Description	Testis-specific serine/threonine-protein kinase 6 (EC 2.7.11.1) (TSSK- 6) (Small serine/threonine kinase) (Serine/threonine-protein kinase SSTK).

PDPK1_MOUSE
NC score	0.864920 (rank : 113)	θ value	4.28545e-26 (rank : 113)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	810
SwissProt Accessions	Q9Z2A0, Q9R1D8, Q9R215	Gene names	Pdpk1, Pdk1
Domain Architecture
Description	3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) (mPDK1).

PLK1_MOUSE
NC score	0.864777 (rank : 114)	θ value	1.47289e-26 (rank : 107)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	806
SwissProt Accessions	Q07832	Gene names	Plk1, Plk
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

MARK1_HUMAN
NC score	0.864694 (rank : 115)	θ value	9.2256e-29 (rank : 68)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	814
SwissProt Accessions	Q9P0L2, Q5VTF9, Q5VTG0, Q96SW9, Q9P251	Gene names	MARK1, KIAA1477, MARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 1).

MARK2_HUMAN
NC score	0.864685 (rank : 116)	θ value	2.68423e-28 (rank : 76)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1056	Shared Neighborhood Hits	848
SwissProt Accessions	Q7KZI7, Q15449, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0	Gene names	MARK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL motif kinase) (EMK1) (PAR1 homolog).

KKCC1_MOUSE
NC score	0.864678 (rank : 117)	θ value	1.63225e-17 (rank : 277)
Query Neighborhood Hits	1580	Target Neighborhood Hits	866	Shared Neighborhood Hits	813
SwissProt Accessions	Q8VBY2, Q9R054	Gene names	Camkk1, Camkk
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

KAPCG_HUMAN
NC score	0.864546 (rank : 118)	θ value	1.99067e-23 (rank : 140)
Query Neighborhood Hits	1580	Target Neighborhood Hits	845	Shared Neighborhood Hits	812
SwissProt Accessions	P22612, O60850, Q86YI1	Gene names	PRKACG
Domain Architecture
Description	cAMP-dependent protein kinase, gamma-catalytic subunit (EC 2.7.11.11) (PKA C-gamma).

MARK2_MOUSE
NC score	0.864535 (rank : 119)	θ value	1.02001e-27 (rank : 87)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1018	Shared Neighborhood Hits	835
SwissProt Accessions	Q05512, Q6PDR4, Q8BR95	Gene names	Mark2, Emk
Domain Architecture
Description	Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase 2) (ELKL Motif Kinase) (EMK1).

MKNK1_MOUSE
NC score	0.864186 (rank : 120)	θ value	2.20094e-22 (rank : 156)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	781
SwissProt Accessions	O08605	Gene names	Mknk1, Mnk1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

KKCC1_HUMAN
NC score	0.864168 (rank : 121)	θ value	4.29542e-18 (rank : 262)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	810
SwissProt Accessions	Q8N5S9, Q9BQH3	Gene names	CAMKK1, CAMKKA
Domain Architecture	No domain graphic available
Description	Calcium/calmodulin-dependent protein kinase kinase 1 (EC 2.7.11.17) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-kinase kinase alpha) (CaM-KK alpha) (CaMKK alpha) (CaMKK 1) (CaM-kinase IV kinase).

CAMKV_HUMAN
NC score	0.863947 (rank : 122)	θ value	7.80994e-28 (rank : 82)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1084	Shared Neighborhood Hits	808
SwissProt Accessions	Q8NCB2, Q6FIB8, Q8NBS8, Q8NC85, Q8NDU4, Q8WTT8, Q9BQC9, Q9H0Q5	Gene names	CAMKV
Domain Architecture	No domain graphic available
Description	CaM kinase-like vesicle-associated protein.

PRKY_HUMAN
NC score	0.863717 (rank : 123)	θ value	4.58923e-20 (rank : 203)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	808
SwissProt Accessions	O43930, O15348, O15349	Gene names	PRKY
Domain Architecture
Description	Serine/threonine-protein kinase PRKY (EC 2.7.11.1).

PLK1_HUMAN
NC score	0.863529 (rank : 124)	θ value	1.92365e-26 (rank : 110)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	807
SwissProt Accessions	P53350, Q15153, Q99746	Gene names	PLK1, PLK
Domain Architecture
Description	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13).

SPEG_HUMAN
NC score	0.863352 (rank : 125)	θ value	3.15612e-45 (rank : 17)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1762	Shared Neighborhood Hits	1060
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

KAPCA_HUMAN
NC score	0.863197 (rank : 126)	θ value	8.93572e-24 (rank : 134)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	810
SwissProt Accessions	P17612, Q9H2Y0, Q9NRB4, Q9NRH9	Gene names	PRKACA, PKACA
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

KS6A5_HUMAN
NC score	0.862989 (rank : 127)	θ value	3.17079e-29 (rank : 64)
Query Neighborhood Hits	1580	Target Neighborhood Hits	855	Shared Neighborhood Hits	814
SwissProt Accessions	O75582, O95316, Q96AF7	Gene names	RPS6KA5, MSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL).

KAPCB_HUMAN
NC score	0.862852 (rank : 128)	θ value	1.16704e-23 (rank : 136)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	807
SwissProt Accessions	P22694, Q59GC0, Q5BNE9, Q5BNF0, Q5BNF1, Q5BNF2, Q5BNF3, Q5CZ92, Q5T1K3, Q7Z3M1, Q8IYR5, Q8IZQ0	Gene names	PRKACB
Domain Architecture
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

KAPCB_MOUSE
NC score	0.862779 (rank : 129)	θ value	5.23862e-24 (rank : 132)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	807
SwissProt Accessions	P68181, P05206, Q3TQH5, Q3UDD0, Q3UTH5	Gene names	Prkacb, Pkacb
Domain Architecture	No domain graphic available
Description	cAMP-dependent protein kinase, beta-catalytic subunit (EC 2.7.11.11) (PKA C-beta).

ULK2_MOUSE
NC score	0.862616 (rank : 130)	θ value	5.06226e-27 (rank : 100)
Query Neighborhood Hits	1580	Target Neighborhood Hits	943	Shared Neighborhood Hits	835
SwissProt Accessions	Q9QY01, Q80TV7, Q9WTP4	Gene names	Ulk2, Kiaa0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) (Serine/threonine-protein kinase Unc51.2).

KAPCA_MOUSE
NC score	0.862554 (rank : 131)	θ value	3.39556e-23 (rank : 146)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	808
SwissProt Accessions	P05132, Q9JID0	Gene names	Prkaca, Pkaca
Domain Architecture
Description	cAMP-dependent protein kinase, alpha-catalytic subunit (EC 2.7.11.11) (PKA C-alpha).

ULK2_HUMAN
NC score	0.862177 (rank : 132)	θ value	4.57862e-28 (rank : 79)
Query Neighborhood Hits	1580	Target Neighborhood Hits	979	Shared Neighborhood Hits	830
SwissProt Accessions	Q8IYT8, O75119	Gene names	ULK2, KIAA0623
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2).

KS6A1_MOUSE
NC score	0.861917 (rank : 133)	θ value	9.2256e-29 (rank : 67)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	815
SwissProt Accessions	P18653	Gene names	Rps6ka1, Rsk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

MARK3_HUMAN
NC score	0.861895 (rank : 134)	θ value	3.62785e-25 (rank : 120)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	811
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

STK11_HUMAN
NC score	0.861674 (rank : 135)	θ value	1.42992e-13 (rank : 391)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	803
SwissProt Accessions	Q15831	Gene names	STK11, LKB1, PJS
Domain Architecture
Description	Serine/threonine-protein kinase 11 (EC 2.7.11.1) (Serine/threonine- protein kinase LKB1) (NY-REN-19 antigen).

PLK3_HUMAN
NC score	0.861316 (rank : 136)	θ value	4.15078e-21 (rank : 178)
Query Neighborhood Hits	1580	Target Neighborhood Hits	865	Shared Neighborhood Hits	814
SwissProt Accessions	Q9H4B4, Q15767, Q96CV1	Gene names	PLK3, CNK, FNK, PRK
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase) (Proliferation-related kinase).

KS6A2_MOUSE
NC score	0.861165 (rank : 137)	θ value	3.17079e-29 (rank : 63)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	821
SwissProt Accessions	Q9WUT3, Q9D2C0	Gene names	Rps6ka2, Rsk3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase- activated protein kinase 1c) (MAPKAPK1C).

PLK3_MOUSE
NC score	0.861151 (rank : 138)	θ value	2.06002e-20 (rank : 196)
Query Neighborhood Hits	1580	Target Neighborhood Hits	863	Shared Neighborhood Hits	812
SwissProt Accessions	Q60806, Q60822, Q9R009	Gene names	Plk3, Cnk, Fnk
Domain Architecture
Description	Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Polo-like kinase 3) (PLK-3) (Cytokine-inducible serine/threonine-protein kinase) (FGF- inducible kinase).

CHK1_MOUSE
NC score	0.860984 (rank : 139)	θ value	5.43371e-13 (rank : 402)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	807
SwissProt Accessions	O35280, O54925, Q8CI40, Q9D0N2	Gene names	Chek1, Chk1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

KS6A6_HUMAN
NC score	0.860910 (rank : 140)	θ value	7.06379e-29 (rank : 65)
Query Neighborhood Hits	1580	Target Neighborhood Hits	853	Shared Neighborhood Hits	813
SwissProt Accessions	Q9UK32, Q8WX28, Q9H4S6	Gene names	RPS6KA6, RSK4
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1) (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4).

MAPK5_MOUSE
NC score	0.860872 (rank : 141)	θ value	1.47631e-18 (rank : 244)
Query Neighborhood Hits	1580	Target Neighborhood Hits	799	Shared Neighborhood Hits	772
SwissProt Accessions	O54992, Q6QME4, Q6QME5, Q6QME6, Q6QME7	Gene names	Mapkapk5
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5).

CHK1_HUMAN
NC score	0.860718 (rank : 142)	θ value	2.43908e-13 (rank : 395)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	803
SwissProt Accessions	O14757	Gene names	CHEK1, CHK1
Domain Architecture
Description	Serine/threonine-protein kinase Chk1 (EC 2.7.11.1).

KS6A4_MOUSE
NC score	0.860496 (rank : 143)	θ value	3.07116e-24 (rank : 130)
Query Neighborhood Hits	1580	Target Neighborhood Hits	866	Shared Neighborhood Hits	816
SwissProt Accessions	Q9Z2B9, Q91X18	Gene names	Rps6ka4, Msk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (RSK-like protein kinase) (RLSK).

PRKX_MOUSE
NC score	0.860368 (rank : 144)	θ value	2.43343e-21 (rank : 174)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	812
SwissProt Accessions	Q922R0, Q3UCD1, Q8BHD6, Q9QZ12	Gene names	Prkx, Pkare
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (PKA-related protein kinase).

KS6A2_HUMAN
NC score	0.860295 (rank : 145)	θ value	1.2049e-28 (rank : 69)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	817
SwissProt Accessions	Q15349, Q15419, Q59GJ3, Q5TI68, Q96J38, Q9UJN5	Gene names	RPS6KA2, RSK3
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1) (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C).

MAPK5_HUMAN
NC score	0.860000 (rank : 146)	θ value	5.07402e-19 (rank : 228)
Query Neighborhood Hits	1580	Target Neighborhood Hits	795	Shared Neighborhood Hits	768
SwissProt Accessions	Q8IW41, O60491, Q86X46, Q9BVX9, Q9UG86	Gene names	MAPKAPK5, PRAK
Domain Architecture	No domain graphic available
Description	MAP kinase-activated protein kinase 5 (EC 2.7.11.1) (MAPK-activated protein kinase 5) (MAPKAP kinase 5) (p38-regulated/activated protein kinase).

KS6A4_HUMAN
NC score	0.859957 (rank : 147)	θ value	1.80048e-24 (rank : 126)
Query Neighborhood Hits	1580	Target Neighborhood Hits	868	Shared Neighborhood Hits	814
SwissProt Accessions	O75676, O75585, Q53ES8	Gene names	RPS6KA4, MSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-4 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 2) (90 kDa ribosomal protein S6 kinase 4) (Ribosomal protein kinase B) (RSKB).

KS6A3_MOUSE
NC score	0.859955 (rank : 148)	θ value	3.3877e-31 (rank : 54)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	819
SwissProt Accessions	P18654, Q03140, Q8K3J8	Gene names	Rps6ka3, Rps6ka-rs1, Rsk2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

KS6A3_HUMAN
NC score	0.859950 (rank : 149)	θ value	3.3877e-31 (rank : 53)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	819
SwissProt Accessions	P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7	Gene names	RPS6KA3, ISPK1, RSK2
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1) (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B).

SPEG_MOUSE
NC score	0.859922 (rank : 150)	θ value	3.85808e-43 (rank : 20)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1959	Shared Neighborhood Hits	1080
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

PRKX_HUMAN
NC score	0.859913 (rank : 151)	θ value	9.24701e-21 (rank : 189)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	808
SwissProt Accessions	P51817	Gene names	PRKX, PKX1
Domain Architecture
Description	Serine/threonine-protein kinase PRKX (EC 2.7.11.1) (Protein kinase PKX1).

PIM2_MOUSE
NC score	0.859806 (rank : 152)	θ value	2.97466e-19 (rank : 222)
Query Neighborhood Hits	1580	Target Neighborhood Hits	809	Shared Neighborhood Hits	783
SwissProt Accessions	Q62070, Q62071, Q62072	Gene names	Pim2, Pim-2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1).

ULK1_HUMAN
NC score	0.859791 (rank : 153)	θ value	3.07116e-24 (rank : 131)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1121	Shared Neighborhood Hits	843
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

KS6A1_HUMAN
NC score	0.859764 (rank : 154)	θ value	1.02001e-27 (rank : 86)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	819
SwissProt Accessions	Q15418, Q5SVM5, Q5SVM8, Q5SVM9, Q96C05, Q9BQK2	Gene names	RPS6KA1, RSK1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1) (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A).

STK36_HUMAN
NC score	0.859663 (rank : 155)	θ value	5.06226e-27 (rank : 98)
Query Neighborhood Hits	1580	Target Neighborhood Hits	896	Shared Neighborhood Hits	819
SwissProt Accessions	Q9NRP7, Q8TC32, Q9H9N9, Q9UF35, Q9ULE2	Gene names	STK36, KIAA1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

PLK2_HUMAN
NC score	0.858698 (rank : 156)	θ value	2.5182e-18 (rank : 252)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	811
SwissProt Accessions	Q9NYY3, O60679, Q96CV7, Q9UE61	Gene names	PLK2, SNK
Domain Architecture
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

ULK4_MOUSE
NC score	0.858484 (rank : 157)	θ value	2.5182e-18 (rank : 256)
Query Neighborhood Hits	1580	Target Neighborhood Hits	793	Shared Neighborhood Hits	766
SwissProt Accessions	Q3V129, Q2VP87, Q32LZ6, Q8BLS0, Q8C8Z5, Q9D4H6	Gene names	Ulk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4).

PLK2_MOUSE
NC score	0.858326 (rank : 158)	θ value	2.5182e-18 (rank : 253)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	810
SwissProt Accessions	P53351	Gene names	Plk2, Snk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-2) (Serine/threonine-protein kinase SNK) (Serum-inducible kinase).

PIM2_HUMAN
NC score	0.858239 (rank : 159)	θ value	5.60996e-18 (rank : 266)
Query Neighborhood Hits	1580	Target Neighborhood Hits	808	Shared Neighborhood Hits	787
SwissProt Accessions	Q9P1W9, Q99739	Gene names	PIM2
Domain Architecture
Description	Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1) (Pim-2h).

STK36_MOUSE
NC score	0.857356 (rank : 160)	θ value	6.18819e-25 (rank : 122)
Query Neighborhood Hits	1580	Target Neighborhood Hits	877	Shared Neighborhood Hits	819
SwissProt Accessions	Q69ZM6, Q6PDI0, Q80XQ6	Gene names	Stk36, Kiaa1278
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog).

SGK2_MOUSE
NC score	0.857067 (rank : 161)	θ value	4.43474e-23 (rank : 149)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	804
SwissProt Accessions	Q9QZS5, Q8R0P6	Gene names	Sgk2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

KS6B2_HUMAN
NC score	0.856941 (rank : 162)	θ value	1.74391e-19 (rank : 217)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	815
SwissProt Accessions	Q9UBS0, O94809, Q9UEC1	Gene names	RPS6KB2, STK14B
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serine/threonine-protein kinase 14 beta).

SGK1_HUMAN
NC score	0.856789 (rank : 163)	θ value	1.99067e-23 (rank : 141)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	809
SwissProt Accessions	O00141, Q5TCN3, Q9UN56	Gene names	SGK, SGK1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

SGK1_MOUSE
NC score	0.856677 (rank : 164)	θ value	4.43474e-23 (rank : 148)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	809
SwissProt Accessions	Q9WVC6	Gene names	Sgk, Sgk1
Domain Architecture
Description	Serine/threonine-protein kinase Sgk1 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 1).

ST32A_HUMAN
NC score	0.856516 (rank : 165)	θ value	2.69047e-20 (rank : 198)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	804
SwissProt Accessions	Q8WU08	Gene names	STK32A
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1) (YANK1).

SGK2_HUMAN
NC score	0.856475 (rank : 166)	θ value	1.99067e-23 (rank : 142)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	803
SwissProt Accessions	Q9HBY8, Q9UKG6	Gene names	SGK2
Domain Architecture
Description	Serine/threonine-protein kinase Sgk2 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 2).

ULK1_MOUSE
NC score	0.856425 (rank : 167)	θ value	1.37858e-24 (rank : 125)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1214	Shared Neighborhood Hits	848
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

ST32B_MOUSE
NC score	0.856288 (rank : 168)	θ value	3.75424e-22 (rank : 161)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	801
SwissProt Accessions	Q9JJX8, Q7TMD3, Q8C4E0	Gene names	Stk32b, Stk32
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1).

KS6B1_HUMAN
NC score	0.856227 (rank : 169)	θ value	5.42112e-21 (rank : 180)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	808
SwissProt Accessions	P23443	Gene names	RPS6KB1
Domain Architecture
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K) (p70-alpha).

ST32A_MOUSE
NC score	0.856077 (rank : 170)	θ value	6.62687e-19 (rank : 234)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	805
SwissProt Accessions	Q8BGW6, Q7TPQ4	Gene names	Stk32a
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32A (EC 2.7.11.1).

KS6B1_MOUSE
NC score	0.856015 (rank : 171)	θ value	5.42112e-21 (rank : 181)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	807
SwissProt Accessions	Q8BSK8, Q8CHX0	Gene names	Rps6kb1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (P70S6K).

ST32B_HUMAN
NC score	0.855965 (rank : 172)	θ value	6.40375e-22 (rank : 166)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	800
SwissProt Accessions	Q9NY57, Q6UXH3, Q8IY14	Gene names	STK32B
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32B (EC 2.7.11.1) (YANK2).

PIM3_HUMAN
NC score	0.855934 (rank : 173)	θ value	1.74391e-19 (rank : 218)
Query Neighborhood Hits	1580	Target Neighborhood Hits	789	Shared Neighborhood Hits	772
SwissProt Accessions	Q86V86, Q68BM2	Gene names	PIM3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

AKT3_HUMAN
NC score	0.855888 (rank : 174)	θ value	1.99067e-23 (rank : 138)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	807
SwissProt Accessions	Q9Y243, Q96QV3, Q9UFP5	Gene names	AKT3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

AKT3_MOUSE
NC score	0.855880 (rank : 175)	θ value	1.99067e-23 (rank : 139)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	807
SwissProt Accessions	Q9WUA6	Gene names	Akt3
Domain Architecture
Description	RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma).

PIM1_HUMAN
NC score	0.855684 (rank : 176)	θ value	4.58923e-20 (rank : 202)
Query Neighborhood Hits	1580	Target Neighborhood Hits	797	Shared Neighborhood Hits	775
SwissProt Accessions	P11309, Q38RT9, Q96RG3	Gene names	PIM1
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

KS6B2_MOUSE
NC score	0.855632 (rank : 177)	θ value	2.5182e-18 (rank : 251)
Query Neighborhood Hits	1580	Target Neighborhood Hits	871	Shared Neighborhood Hits	812
SwissProt Accessions	Q9Z1M4	Gene names	Rps6kb2
Domain Architecture
Description	Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2).

ST32C_MOUSE
NC score	0.855553 (rank : 178)	θ value	1.13037e-18 (rank : 242)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	797
SwissProt Accessions	Q8QZV4, Q9JJG4	Gene names	Stk32c, Pkek
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1).

PIM1_MOUSE
NC score	0.855461 (rank : 179)	θ value	7.0802e-21 (rank : 183)
Query Neighborhood Hits	1580	Target Neighborhood Hits	787	Shared Neighborhood Hits	763
SwissProt Accessions	P06803	Gene names	Pim1, Pim-1
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase Pim-1 (EC 2.7.11.1).

KS6A5_MOUSE
NC score	0.855299 (rank : 180)	θ value	2.43343e-21 (rank : 173)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	812
SwissProt Accessions	Q8C050, Q8CI92	Gene names	Rps6ka5, Msk1
Domain Architecture
Description	Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear mitogen- and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK).

AKT2_HUMAN
NC score	0.854987 (rank : 181)	θ value	3.07116e-24 (rank : 128)
Query Neighborhood Hits	1580	Target Neighborhood Hits	878	Shared Neighborhood Hits	804
SwissProt Accessions	P31751, Q68GC0	Gene names	AKT2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

PIM3_MOUSE
NC score	0.854971 (rank : 182)	θ value	2.06002e-20 (rank : 195)
Query Neighborhood Hits	1580	Target Neighborhood Hits	783	Shared Neighborhood Hits	767
SwissProt Accessions	P58750	Gene names	Pim3
Domain Architecture
Description	Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1).

AKT2_MOUSE
NC score	0.854452 (rank : 183)	θ value	1.37858e-24 (rank : 124)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	803
SwissProt Accessions	Q60823	Gene names	Akt2
Domain Architecture
Description	RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta).

ST32C_HUMAN
NC score	0.854414 (rank : 184)	θ value	1.13037e-18 (rank : 241)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	800
SwissProt Accessions	Q86UX6, Q5T0Q5, Q86UE1	Gene names	STK32C
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (YANK3).

KGP2_HUMAN
NC score	0.854028 (rank : 185)	θ value	8.36355e-22 (rank : 168)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1023	Shared Neighborhood Hits	887
SwissProt Accessions	Q13237, O00125, O60916	Gene names	PRKG2, PRKGR2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

AKT1_HUMAN
NC score	0.853673 (rank : 186)	θ value	2.20094e-22 (rank : 155)
Query Neighborhood Hits	1580	Target Neighborhood Hits	885	Shared Neighborhood Hits	813
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

KGP2_MOUSE
NC score	0.853655 (rank : 187)	θ value	4.15078e-21 (rank : 176)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1029	Shared Neighborhood Hits	900
SwissProt Accessions	Q61410	Gene names	Prkg2, Prkgr2
Domain Architecture
Description	cGMP-dependent protein kinase 2 (EC 2.7.11.12) (CGK 2) (cGKII) (Type II cGMP-dependent protein kinase).

AKT1_MOUSE
NC score	0.853385 (rank : 188)	θ value	9.87957e-23 (rank : 152)
Query Neighborhood Hits	1580	Target Neighborhood Hits	878	Shared Neighborhood Hits	811
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

SGK3_HUMAN
NC score	0.852394 (rank : 189)	θ value	2.59989e-23 (rank : 145)
Query Neighborhood Hits	1580	Target Neighborhood Hits	877	Shared Neighborhood Hits	803
SwissProt Accessions	Q96BR1, Q9P1Q7, Q9UKG5	Gene names	SGK3, SGKL
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like).

SGK3_MOUSE
NC score	0.852147 (rank : 190)	θ value	9.87957e-23 (rank : 154)
Query Neighborhood Hits	1580	Target Neighborhood Hits	882	Shared Neighborhood Hits	804
SwissProt Accessions	Q9ERE3, Q3UAY2	Gene names	Sgk3, Cisk, Sgkl
Domain Architecture
Description	Serine/threonine-protein kinase Sgk3 (EC 2.7.11.1) (Serum/glucocorticoid-regulated kinase 3) (Serum/glucocorticoid- regulated kinase-like) (Cytokine-independent survival kinase).

RK_MOUSE
NC score	0.850401 (rank : 191)	θ value	1.2077e-20 (rank : 191)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	801
SwissProt Accessions	Q9WVL4	Gene names	Grk1, Rhok
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

NEK3_MOUSE
NC score	0.849472 (rank : 192)	θ value	2.35696e-16 (rank : 314)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	815
SwissProt Accessions	Q9R0A5, Q9Z0X9	Gene names	Nek3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3).

KPCI_MOUSE
NC score	0.848641 (rank : 193)	θ value	7.82807e-20 (rank : 210)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	816
SwissProt Accessions	Q62074	Gene names	Prkci, Pkcl
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota).

KPCI_HUMAN
NC score	0.848568 (rank : 194)	θ value	7.82807e-20 (rank : 209)
Query Neighborhood Hits	1580	Target Neighborhood Hits	885	Shared Neighborhood Hits	817
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

NEK3_HUMAN
NC score	0.848552 (rank : 195)	θ value	1.52774e-15 (rank : 337)
Query Neighborhood Hits	1580	Target Neighborhood Hits	865	Shared Neighborhood Hits	820
SwissProt Accessions	P51956, Q8WUN5	Gene names	NEK3
Domain Architecture
Description	Serine/threonine-protein kinase Nek3 (EC 2.7.11.1) (NimA-related protein kinase 3) (HSPK 36).

KGP1B_MOUSE
NC score	0.848058 (rank : 196)	θ value	1.33526e-19 (rank : 216)
Query Neighborhood Hits	1580	Target Neighborhood Hits	922	Shared Neighborhood Hits	833
SwissProt Accessions	Q9Z0Z0	Gene names	Prkg1, Prkg1b, Prkgr1b
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

KGP1B_HUMAN
NC score	0.848000 (rank : 197)	θ value	1.33526e-19 (rank : 215)
Query Neighborhood Hits	1580	Target Neighborhood Hits	921	Shared Neighborhood Hits	833
SwissProt Accessions	P14619	Gene names	PRKG1, PRKG1B, PRKGR1B
Domain Architecture
Description	cGMP-dependent protein kinase 1, beta isozyme (EC 2.7.11.12) (cGK 1 beta) (cGKI-beta).

IKKB_MOUSE
NC score	0.847763 (rank : 198)	θ value	2.7842e-17 (rank : 282)
Query Neighborhood Hits	1580	Target Neighborhood Hits	984	Shared Neighborhood Hits	896
SwissProt Accessions	O88351, Q9R1J6	Gene names	Ikbkb, Ikkb
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

KGP1A_HUMAN
NC score	0.847645 (rank : 199)	θ value	1.33526e-19 (rank : 214)
Query Neighborhood Hits	1580	Target Neighborhood Hits	901	Shared Neighborhood Hits	819
SwissProt Accessions	Q13976	Gene names	PRKG1, PRKGR1A
Domain Architecture
Description	cGMP-dependent protein kinase 1, alpha isozyme (EC 2.7.11.12) (CGK 1 alpha) (cGKI-alpha).

RK_HUMAN
NC score	0.847457 (rank : 200)	θ value	6.62687e-19 (rank : 233)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	800
SwissProt Accessions	Q15835	Gene names	GRK1, RHOK
Domain Architecture
Description	Rhodopsin kinase precursor (EC 2.7.11.14) (RK) (G protein-coupled receptor kinase 1).

IKKB_HUMAN
NC score	0.847176 (rank : 201)	θ value	6.20254e-17 (rank : 294)
Query Neighborhood Hits	1580	Target Neighborhood Hits	980	Shared Neighborhood Hits	898
SwissProt Accessions	O14920, O75327	Gene names	IKBKB, IKKB
Domain Architecture
Description	Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (I-kappa-B-kinase beta) (IkBKB) (IKK-beta) (IKK-B) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB).

NEK2_HUMAN
NC score	0.847047 (rank : 202)	θ value	2.98157e-11 (rank : 473)
Query Neighborhood Hits	1580	Target Neighborhood Hits	908	Shared Neighborhood Hits	839
SwissProt Accessions	P51955, Q53FD6, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9	Gene names	NEK2, NLK1
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21).

NEK2_MOUSE
NC score	0.846780 (rank : 203)	θ value	5.62301e-10 (rank : 520)
Query Neighborhood Hits	1580	Target Neighborhood Hits	876	Shared Neighborhood Hits	814
SwissProt Accessions	O35942, O35959	Gene names	Nek2
Domain Architecture
Description	Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (NimA-related protein kinase 2).

PKN3_HUMAN
NC score	0.846672 (rank : 204)	θ value	7.0802e-21 (rank : 184)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	835
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

NEK1_HUMAN
NC score	0.846395 (rank : 205)	θ value	5.25075e-16 (rank : 326)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1129	Shared Neighborhood Hits	901
SwissProt Accessions	Q96PY6, Q9Y594	Gene names	NEK1, KIAA1901
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1) (NY-REN-55 antigen).

MAST3_HUMAN
NC score	0.846233 (rank : 206)	θ value	4.15078e-21 (rank : 177)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1128	Shared Neighborhood Hits	851
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

KPCZ_HUMAN
NC score	0.845970 (rank : 207)	θ value	1.5773e-20 (rank : 192)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	816
SwissProt Accessions	Q05513, Q15207, Q5SYT5, Q969S4	Gene names	PRKCZ, PKC2
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

KPCZ_MOUSE
NC score	0.845935 (rank : 208)	θ value	4.58923e-20 (rank : 200)
Query Neighborhood Hits	1580	Target Neighborhood Hits	882	Shared Neighborhood Hits	817
SwissProt Accessions	Q02956	Gene names	Prkcz, Pkcz
Domain Architecture
Description	Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta).

PKN2_MOUSE
NC score	0.845896 (rank : 209)	θ value	5.07402e-19 (rank : 229)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	836
SwissProt Accessions	Q8BWW9, Q80WS2, Q8BJL7	Gene names	Pkn2, Prkcl2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

PKN2_HUMAN
NC score	0.845667 (rank : 210)	θ value	2.97466e-19 (rank : 223)
Query Neighborhood Hits	1580	Target Neighborhood Hits	892	Shared Neighborhood Hits	838
SwissProt Accessions	Q16513, Q9H1W4	Gene names	PKN2, PRK2, PRKCL2
Domain Architecture
Description	Serine/threonine-protein kinase N2 (EC 2.7.11.13) (Protein kinase C- like 2) (Protein-kinase C-related kinase 2).

MAST2_MOUSE
NC score	0.845309 (rank : 211)	θ value	2.87452e-22 (rank : 159)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1110	Shared Neighborhood Hits	847
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

GRK6_HUMAN
NC score	0.845178 (rank : 212)	θ value	5.42112e-21 (rank : 179)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	798
SwissProt Accessions	P43250, O60541, Q13652	Gene names	GRK6, GPRK6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

PAK4_HUMAN
NC score	0.845164 (rank : 213)	θ value	1.058e-16 (rank : 304)
Query Neighborhood Hits	1580	Target Neighborhood Hits	924	Shared Neighborhood Hits	832
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PKN3_MOUSE
NC score	0.845116 (rank : 214)	θ value	6.62687e-19 (rank : 232)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	845
SwissProt Accessions	Q8K045	Gene names	Pkn3, Pknbeta
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PAK6_HUMAN
NC score	0.844748 (rank : 215)	θ value	2.35696e-16 (rank : 315)
Query Neighborhood Hits	1580	Target Neighborhood Hits	915	Shared Neighborhood Hits	822
SwissProt Accessions	Q9NQU5	Gene names	PAK6, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (p21-activated kinase 6) (PAK-6) (PAK-5).

GRK5_MOUSE
NC score	0.844701 (rank : 216)	θ value	5.60996e-18 (rank : 265)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	791
SwissProt Accessions	Q8VEB1, O70292, O70297	Gene names	Grk5, Gprk5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

GRK6_MOUSE
NC score	0.844531 (rank : 217)	θ value	2.69047e-20 (rank : 197)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	797
SwissProt Accessions	O70293, O70294, O70295	Gene names	Grk6, Gprk6
Domain Architecture
Description	G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6).

GRK5_HUMAN
NC score	0.844325 (rank : 218)	θ value	7.32683e-18 (rank : 267)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	791
SwissProt Accessions	P34947	Gene names	GRK5, GPRK5
Domain Architecture
Description	G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5).

PAK7_MOUSE
NC score	0.844306 (rank : 219)	θ value	1.63225e-17 (rank : 278)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	813
SwissProt Accessions	Q8C015, Q3TQJ7, Q6RWS7	Gene names	Pak7, Pak5
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (p21-activated kinase 5).

NEK1_MOUSE
NC score	0.844250 (rank : 220)	θ value	1.16975e-15 (rank : 333)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1311	Shared Neighborhood Hits	928
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

KPCT_MOUSE
NC score	0.844244 (rank : 221)	θ value	7.82807e-20 (rank : 211)
Query Neighborhood Hits	1580	Target Neighborhood Hits	895	Shared Neighborhood Hits	818
SwissProt Accessions	Q02111	Gene names	Prkcq, Pkcq
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

KPCL_MOUSE
NC score	0.844203 (rank : 222)	θ value	8.10077e-17 (rank : 300)
Query Neighborhood Hits	1580	Target Neighborhood Hits	891	Shared Neighborhood Hits	807
SwissProt Accessions	P23298	Gene names	Prkch, Pkch
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

KPCT_HUMAN
NC score	0.844104 (rank : 223)	θ value	1.02238e-19 (rank : 212)
Query Neighborhood Hits	1580	Target Neighborhood Hits	897	Shared Neighborhood Hits	820
SwissProt Accessions	Q04759, Q3MJF1, Q64FY5, Q9H508, Q9H549	Gene names	PRKCQ, PRKCT
Domain Architecture
Description	Protein kinase C theta type (EC 2.7.11.13) (nPKC-theta).

PAK7_HUMAN
NC score	0.844002 (rank : 224)	θ value	2.7842e-17 (rank : 284)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	814
SwissProt Accessions	Q9P286, Q5W115, Q9BX09, Q9ULF6	Gene names	PAK7, KIAA1264, PAK5
Domain Architecture
Description	Serine/threonine-protein kinase PAK 7 (EC 2.7.11.1) (p21-activated kinase 7) (PAK-7) (PAK-5).

MAST2_HUMAN
NC score	0.843609 (rank : 225)	θ value	4.9032e-22 (rank : 163)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1189	Shared Neighborhood Hits	856
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

GRK7_HUMAN
NC score	0.843476 (rank : 226)	θ value	4.02038e-16 (rank : 321)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	794
SwissProt Accessions	Q8WTQ7	Gene names	GRK7, GPRK7
Domain Architecture
Description	G protein-coupled receptor kinase 7 precursor (EC 2.7.11.16) (G protein-coupled receptor kinase GRK7).

PAK2_HUMAN
NC score	0.843335 (rank : 227)	θ value	7.32683e-18 (rank : 269)
Query Neighborhood Hits	1580	Target Neighborhood Hits	862	Shared Neighborhood Hits	819
SwissProt Accessions	Q13177, Q13154	Gene names	PAK2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase).

PAK2_MOUSE
NC score	0.843325 (rank : 228)	θ value	7.32683e-18 (rank : 270)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	816
SwissProt Accessions	Q8CIN4	Gene names	Pak2
Domain Architecture
Description	Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (p21-activated kinase 2) (PAK-2).

KPCL_HUMAN
NC score	0.842821 (rank : 229)	θ value	1.80466e-16 (rank : 311)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	807
SwissProt Accessions	P24723, Q16246	Gene names	PRKCH, PKCL
Domain Architecture
Description	Protein kinase C eta type (EC 2.7.11.13) (nPKC-eta) (PKC-L).

TLK2_MOUSE
NC score	0.842682 (rank : 230)	θ value	7.09661e-13 (rank : 408)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1088	Shared Neighborhood Hits	907
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

PKN1_MOUSE
NC score	0.842611 (rank : 231)	θ value	2.7842e-17 (rank : 285)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	823
SwissProt Accessions	P70268, Q7TST2	Gene names	Pkn1, Pkn, Prk1, Prkcl1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N).

KPCE_MOUSE
NC score	0.842478 (rank : 232)	θ value	5.07402e-19 (rank : 227)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	806
SwissProt Accessions	P16054	Gene names	Prkce, Pkce, Pkcea
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

MAST1_HUMAN
NC score	0.842407 (rank : 233)	θ value	7.56453e-23 (rank : 150)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1146	Shared Neighborhood Hits	841
SwissProt Accessions	Q9Y2H9, O00114, Q8N6X0	Gene names	MAST1, KIAA0973
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

KPCE_HUMAN
NC score	0.842400 (rank : 234)	θ value	2.97466e-19 (rank : 221)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	806
SwissProt Accessions	Q02156, Q53SL4, Q53SM5, Q9UE81	Gene names	PRKCE, PKCE
Domain Architecture
Description	Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon).

IKKA_MOUSE
NC score	0.842377 (rank : 235)	θ value	6.85773e-16 (rank : 328)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	823
SwissProt Accessions	Q60680, Q80VU2, Q9D2X3	Gene names	Chuk, Ikka
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

TLK2_HUMAN
NC score	0.842204 (rank : 236)	θ value	7.09661e-13 (rank : 407)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1044	Shared Neighborhood Hits	886
SwissProt Accessions	Q86UE8, Q9UKI7, Q9Y4F7	Gene names	TLK2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2) (PKU-alpha).

MAST1_MOUSE
NC score	0.842105 (rank : 237)	θ value	2.59989e-23 (rank : 144)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1123	Shared Neighborhood Hits	837
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

PKN1_HUMAN
NC score	0.841985 (rank : 238)	θ value	1.63225e-17 (rank : 279)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	823
SwissProt Accessions	Q16512, Q15143, Q8IUV5	Gene names	PKN1, PKN, PRK1, PRKCL1
Domain Architecture
Description	Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protein kinase C- like 1) (Protein-kinase C-related kinase 1) (Protein kinase C-like PKN) (Serine-threonine protein kinase N) (Protein kinase PKN-alpha).

NEK6_HUMAN
NC score	0.841951 (rank : 239)	θ value	7.56453e-23 (rank : 151)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	815
SwissProt Accessions	Q9HC98, Q96E83, Q9ULX2	Gene names	NEK6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6) (Protein kinase SID6-1512).

NEK6_MOUSE
NC score	0.841753 (rank : 240)	θ value	9.87957e-23 (rank : 153)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	815
SwissProt Accessions	Q9ES70, Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8	Gene names	Nek6
Domain Architecture
Description	Serine/threonine-protein kinase Nek6 (EC 2.7.11.1) (NimA-related protein kinase 6).

GRK4_HUMAN
NC score	0.841641 (rank : 241)	θ value	4.29542e-18 (rank : 261)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	793
SwissProt Accessions	P32298, O00641, O00642, Q13293, Q13294, Q13295, Q14453, Q14725, Q15313, Q15314, Q15315, Q15316	Gene names	GRK4, GPRK2L, GPRK4
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1).

PAK4_MOUSE
NC score	0.841041 (rank : 242)	θ value	2.20605e-14 (rank : 375)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1098	Shared Neighborhood Hits	840
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

IKKA_HUMAN
NC score	0.840851 (rank : 243)	θ value	2.60593e-15 (rank : 346)
Query Neighborhood Hits	1580	Target Neighborhood Hits	863	Shared Neighborhood Hits	816
SwissProt Accessions	O15111, O14666, Q13132, Q92467	Gene names	CHUK, IKKA
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase alpha subunit (EC 2.7.11.10) (I kappa-B kinase alpha) (IkBKA) (IKK-alpha) (IKK-A) (IkappaB kinase) (I-kappa-B kinase 1) (IKK1) (Conserved helix-loop- helix ubiquitous kinase) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA).

M3K2_MOUSE
NC score	0.840724 (rank : 244)	θ value	3.40345e-15 (rank : 349)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	810
SwissProt Accessions	Q61083	Gene names	Map3k2, Mekk2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

KPCD_HUMAN
NC score	0.840313 (rank : 245)	θ value	1.24977e-17 (rank : 276)
Query Neighborhood Hits	1580	Target Neighborhood Hits	900	Shared Neighborhood Hits	815
SwissProt Accessions	Q05655, Q15144	Gene names	PRKCD
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

KPCD_MOUSE
NC score	0.840304 (rank : 246)	θ value	2.5182e-18 (rank : 250)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	811
SwissProt Accessions	P28867, Q91V85, Q9Z333	Gene names	Prkcd, Pkcd
Domain Architecture
Description	Protein kinase C delta type (EC 2.7.11.13) (nPKC-delta).

PAK3_MOUSE
NC score	0.840293 (rank : 247)	θ value	1.38178e-16 (rank : 309)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	819
SwissProt Accessions	Q61036, O88645, Q8K1R5, Q8K1R6	Gene names	Pak3, Pak-3, Pakb, Stk4
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B).

GRK4_MOUSE
NC score	0.840264 (rank : 248)	θ value	5.07402e-19 (rank : 226)
Query Neighborhood Hits	1580	Target Neighborhood Hits	808	Shared Neighborhood Hits	788
SwissProt Accessions	O70291	Gene names	Grk4, Gprk2l
Domain Architecture
Description	G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4).

PAK3_HUMAN
NC score	0.840031 (rank : 249)	θ value	1.38178e-16 (rank : 308)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	818
SwissProt Accessions	O75914, Q5JWX1, Q5JWX2, Q7Z2D6, Q7Z2E4, Q7Z3Z8, Q8WWK5, Q8WX23, Q9P0J8	Gene names	PAK3, OPHN3
Domain Architecture
Description	Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1) (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3).

ST38L_HUMAN
NC score	0.840014 (rank : 250)	θ value	6.62687e-19 (rank : 235)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	781
SwissProt Accessions	Q9Y2H1, Q8TBX7	Gene names	STK38L, KIAA0965, NDR2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

TLK1_MOUSE
NC score	0.839931 (rank : 251)	θ value	1.58096e-12 (rank : 422)
Query Neighborhood Hits	1580	Target Neighborhood Hits	947	Shared Neighborhood Hits	839
SwissProt Accessions	Q8C0V0	Gene names	Tlk1
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1).

PAK1_HUMAN
NC score	0.839878 (rank : 252)	θ value	3.28887e-18 (rank : 258)
Query Neighborhood Hits	1580	Target Neighborhood Hits	873	Shared Neighborhood Hits	815
SwissProt Accessions	Q13153, O75561, Q13567, Q32M53, Q32M54, Q86W79	Gene names	PAK1
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK).

STK38_HUMAN
NC score	0.839453 (rank : 253)	θ value	3.28887e-18 (rank : 260)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	790
SwissProt Accessions	Q15208	Gene names	STK38, NDR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

TLK1_HUMAN
NC score	0.839437 (rank : 254)	θ value	1.58096e-12 (rank : 421)
Query Neighborhood Hits	1580	Target Neighborhood Hits	967	Shared Neighborhood Hits	849
SwissProt Accessions	Q9UKI8, Q14150, Q8N591, Q9NYH2, Q9Y4F6	Gene names	TLK1, KIAA0137
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (Tousled- like kinase 1) (PKU-beta).

NEK4_MOUSE
NC score	0.839417 (rank : 255)	θ value	8.11959e-09 (rank : 588)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	820
SwissProt Accessions	Q9Z1J2, O35673, Q9R1J1	Gene names	Nek4, Stk2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2).

M3K3_MOUSE
NC score	0.839164 (rank : 256)	θ value	1.99529e-15 (rank : 341)
Query Neighborhood Hits	1580	Target Neighborhood Hits	876	Shared Neighborhood Hits	819
SwissProt Accessions	Q61084	Gene names	Map3k3, Mekk3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

PAK1_MOUSE
NC score	0.839155 (rank : 257)	θ value	3.28887e-18 (rank : 259)
Query Neighborhood Hits	1580	Target Neighborhood Hits	878	Shared Neighborhood Hits	815
SwissProt Accessions	O88643	Gene names	Pak1, Paka
Domain Architecture
Description	Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A).

STK38_MOUSE
NC score	0.838965 (rank : 258)	θ value	7.32683e-18 (rank : 273)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	790
SwissProt Accessions	Q91VJ4	Gene names	Stk38, Ndr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1).

M3K1_MOUSE
NC score	0.838948 (rank : 259)	θ value	7.58209e-15 (rank : 364)
Query Neighborhood Hits	1580	Target Neighborhood Hits	952	Shared Neighborhood Hits	828
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

TBK1_MOUSE
NC score	0.838947 (rank : 260)	θ value	1.53129e-07 (rank : 655)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	843
SwissProt Accessions	Q9WUN2, Q9CT90, Q9DC03	Gene names	Tbk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K).

M3K14_HUMAN
NC score	0.838665 (rank : 261)	θ value	2.88119e-14 (rank : 377)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	799
SwissProt Accessions	Q99558, Q8IYN1	Gene names	MAP3K14, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK).

M3K2_HUMAN
NC score	0.838545 (rank : 262)	θ value	1.68911e-14 (rank : 369)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	811
SwissProt Accessions	Q9Y2U5, Q53QL9, Q53S75, Q59GZ6, Q8NC32, Q9NYK3	Gene names	MAP3K2, MAPKKK2, MEKK2
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2).

M3K3_HUMAN
NC score	0.838387 (rank : 263)	θ value	1.68911e-14 (rank : 370)
Query Neighborhood Hits	1580	Target Neighborhood Hits	885	Shared Neighborhood Hits	819
SwissProt Accessions	Q99759	Gene names	MAP3K3, MAPKKK3, MEKK3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3).

NEK4_HUMAN
NC score	0.837938 (rank : 264)	θ value	7.34386e-10 (rank : 529)
Query Neighborhood Hits	1580	Target Neighborhood Hits	883	Shared Neighborhood Hits	817
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

NEK11_HUMAN
NC score	0.837409 (rank : 265)	θ value	2.28291e-11 (rank : 469)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1043	Shared Neighborhood Hits	901
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

TBK1_HUMAN
NC score	0.836995 (rank : 266)	θ value	2.61198e-07 (rank : 663)
Query Neighborhood Hits	1580	Target Neighborhood Hits	861	Shared Neighborhood Hits	822
SwissProt Accessions	Q9UHD2, Q8IYV3, Q9NUJ5	Gene names	TBK1, NAK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (TANK-binding kinase 1) (T2K) (NF-kappa-B-activating kinase).

NEK11_MOUSE
NC score	0.836886 (rank : 267)	θ value	1.33837e-11 (rank : 459)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	825
SwissProt Accessions	Q8C0Q4, Q8BLS6, Q8BW62	Gene names	Nek11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

NEK8_MOUSE
NC score	0.836787 (rank : 268)	θ value	9.24701e-21 (rank : 188)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	814
SwissProt Accessions	Q91ZR4, Q3U498, Q9D685	Gene names	Nek8, Jck
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8).

NEK8_HUMAN
NC score	0.836755 (rank : 269)	θ value	9.24701e-21 (rank : 187)
Query Neighborhood Hits	1580	Target Neighborhood Hits	872	Shared Neighborhood Hits	813
SwissProt Accessions	Q86SG6, Q2M1S6, Q8NDH1	Gene names	NEK8, JCK, NEK12A
Domain Architecture
Description	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (NIMA-related kinase 12a).

NEK7_MOUSE
NC score	0.836664 (rank : 270)	θ value	8.65492e-19 (rank : 238)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	814
SwissProt Accessions	Q9ES74, Q3UEV7	Gene names	Nek7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

DMPK_HUMAN
NC score	0.836422 (rank : 271)	θ value	5.60996e-18 (rank : 263)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	844
SwissProt Accessions	Q09013, Q16205	Gene names	DMPK, MDPK
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

NEK7_HUMAN
NC score	0.836251 (rank : 272)	θ value	1.92812e-18 (rank : 248)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	813
SwissProt Accessions	Q8TDX7	Gene names	NEK7
Domain Architecture
Description	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (NimA-related protein kinase 7).

DMPK_MOUSE
NC score	0.836140 (rank : 273)	θ value	4.74913e-17 (rank : 290)
Query Neighborhood Hits	1580	Target Neighborhood Hits	908	Shared Neighborhood Hits	836
SwissProt Accessions	P54265	Gene names	Dmpk, Dm15, Mdpk
Domain Architecture
Description	Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK).

ST38L_MOUSE
NC score	0.835645 (rank : 274)	θ value	1.92812e-18 (rank : 249)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	779
SwissProt Accessions	Q7TSE6, Q6P6K6, Q8BWK4	Gene names	Stk38l, Ndr2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2).

IKKE_HUMAN
NC score	0.835547 (rank : 275)	θ value	6.64225e-11 (rank : 480)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	802
SwissProt Accessions	Q14164	Gene names	IKBKE, IKKE, IKKI, KIAA0151
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

M3K6_HUMAN
NC score	0.835467 (rank : 276)	θ value	9.90251e-15 (rank : 366)
Query Neighborhood Hits	1580	Target Neighborhood Hits	889	Shared Neighborhood Hits	822
SwissProt Accessions	O95382	Gene names	MAP3K6, MAPKKK6
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 6 (EC 2.7.11.25).

ARBK2_HUMAN
NC score	0.835398 (rank : 277)	θ value	7.58209e-15 (rank : 362)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	799
SwissProt Accessions	P35626, Q9UGW9	Gene names	ADRBK2, BARK2, GRK3
Domain Architecture
Description	Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3).

ARBK1_HUMAN
NC score	0.835232 (rank : 278)	θ value	2.20605e-14 (rank : 372)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	803
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

M3K14_MOUSE
NC score	0.834927 (rank : 279)	θ value	1.52774e-15 (rank : 335)
Query Neighborhood Hits	1580	Target Neighborhood Hits	889	Shared Neighborhood Hits	795
SwissProt Accessions	Q9WUL6	Gene names	Map3k14, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF- kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK).

CSKP_MOUSE
NC score	0.834814 (rank : 280)	θ value	1.73987e-27 (rank : 91)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1027	Shared Neighborhood Hits	819
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

M3K4_HUMAN
NC score	0.834212 (rank : 281)	θ value	3.18553e-13 (rank : 399)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	829
SwissProt Accessions	Q9Y6R4, Q92612	Gene names	MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1).

ARBK1_MOUSE
NC score	0.834141 (rank : 282)	θ value	2.20605e-14 (rank : 373)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	800
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

CDKL3_MOUSE
NC score	0.833977 (rank : 283)	θ value	3.88503e-19 (rank : 224)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	808
SwissProt Accessions	Q8BLF2, Q5M6W2, Q8BKR2, Q8BL49, Q8BVE0, Q8K134	Gene names	Cdkl3
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22).

MKNK1_HUMAN
NC score	0.833945 (rank : 284)	θ value	1.38178e-16 (rank : 307)
Query Neighborhood Hits	1580	Target Neighborhood Hits	701	Shared Neighborhood Hits	677
SwissProt Accessions	Q9BUB5, O00312, Q5TC06, Q6V0N6	Gene names	MKNK1, MNK1
Domain Architecture
Description	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (Mnk1).

M3K5_HUMAN
NC score	0.833892 (rank : 285)	θ value	8.38298e-14 (rank : 381)
Query Neighborhood Hits	1580	Target Neighborhood Hits	868	Shared Neighborhood Hits	814
SwissProt Accessions	Q99683, Q5THN3, Q99461	Gene names	MAP3K5, ASK1, MAPKKK5, MEKK5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

IKKE_MOUSE
NC score	0.833887 (rank : 286)	θ value	8.67504e-11 (rank : 483)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	811
SwissProt Accessions	Q9R0T8	Gene names	Ikbke, Ikke, Ikki
Domain Architecture
Description	Inhibitor of nuclear factor kappa-B kinase epsilon subunit (EC 2.7.11.10) (I kappa-B kinase epsilon) (IkBKE) (IKK-epsilon) (IKK- E) (Inducible I kappa-B kinase) (IKK-i).

M3K5_MOUSE
NC score	0.833831 (rank : 287)	θ value	8.38298e-14 (rank : 382)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	812
SwissProt Accessions	O35099	Gene names	Map3k5, Ask1, Mekk5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1).

M3K15_HUMAN
NC score	0.833309 (rank : 288)	θ value	8.95645e-16 (rank : 330)
Query Neighborhood Hits	1580	Target Neighborhood Hits	914	Shared Neighborhood Hits	839
SwissProt Accessions	Q6ZN16, Q5JPR4, Q6ZMV3	Gene names	MAP3K15
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).

M3K4_MOUSE
NC score	0.833045 (rank : 289)	θ value	9.26847e-13 (rank : 410)
Query Neighborhood Hits	1580	Target Neighborhood Hits	924	Shared Neighborhood Hits	832
SwissProt Accessions	O08648, O08649, O70124	Gene names	Map3k4, Mekk4
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).

TTK_HUMAN
NC score	0.832762 (rank : 290)	θ value	2.13673e-09 (rank : 557)
Query Neighborhood Hits	1580	Target Neighborhood Hits	816	Shared Neighborhood Hits	761
SwissProt Accessions	P33981	Gene names	TTK, MPS1L1
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT).

CDKL3_HUMAN
NC score	0.832507 (rank : 291)	θ value	4.74913e-17 (rank : 289)
Query Neighborhood Hits	1580	Target Neighborhood Hits	853	Shared Neighborhood Hits	809
SwissProt Accessions	Q8IVW4, Q9P114	Gene names	CDKL3, NKIAMRE
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine protein kinase NKIAMRE).

CSKP_HUMAN
NC score	0.832432 (rank : 292)	θ value	1.73987e-27 (rank : 90)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1022	Shared Neighborhood Hits	816
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

SLK_HUMAN
NC score	0.831845 (rank : 293)	θ value	1.63225e-17 (rank : 280)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1775	Shared Neighborhood Hits	1072
SwissProt Accessions	Q9H2G2, O00211, Q6P1Z4, Q86WU7, Q86WW1, Q92603, Q9NQL0, Q9NQL1	Gene names	SLK, KIAA0204, STK2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (hSLK) (Serine/threonine-protein kinase 2) (CTCL tumor antigen se20-9).

MAST4_HUMAN
NC score	0.831816 (rank : 294)	θ value	4.9032e-22 (rank : 164)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1804	Shared Neighborhood Hits	898
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

SLK_MOUSE
NC score	0.831697 (rank : 295)	θ value	7.32683e-18 (rank : 271)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1798	Shared Neighborhood Hits	1076
SwissProt Accessions	O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41	Gene names	Slk, Kiaa0204, Stk2
Domain Architecture	No domain graphic available
Description	STE20-like serine/threonine-protein kinase (EC 2.7.11.1) (STE20-like kinase) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (mSLK) (Serine/threonine-protein kinase 2) (STE20-related kinase SMAK) (Etk4).

MASTL_HUMAN
NC score	0.831140 (rank : 296)	θ value	1.25267e-09 (rank : 541)
Query Neighborhood Hits	1580	Target Neighborhood Hits	894	Shared Neighborhood Hits	814
SwissProt Accessions	Q96GX5, Q5T8D5, Q5T8D7, Q8NCD6, Q96SJ5	Gene names	MASTL, THC2
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

TTK_MOUSE
NC score	0.830668 (rank : 297)	θ value	2.79066e-09 (rank : 561)
Query Neighborhood Hits	1580	Target Neighborhood Hits	803	Shared Neighborhood Hits	744
SwissProt Accessions	P35761	Gene names	Ttk, Esk
Domain Architecture
Description	Dual specificity protein kinase TTK (EC 2.7.12.1) (ESK) (PYT).

CDKL5_HUMAN
NC score	0.830193 (rank : 298)	θ value	5.8054e-15 (rank : 355)
Query Neighborhood Hits	1580	Target Neighborhood Hits	967	Shared Neighborhood Hits	820
SwissProt Accessions	O76039, Q14198, Q5H985, Q9UJL6	Gene names	CDKL5, STK9
Domain Architecture
Description	Cyclin-dependent kinase-like 5 (EC 2.7.11.22) (Serine/threonine- protein kinase 9).

MRCKG_HUMAN
NC score	0.829996 (rank : 299)	θ value	4.44505e-15 (rank : 351)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1519	Shared Neighborhood Hits	1038
SwissProt Accessions	Q6DT37, O00565	Gene names	CDC42BPG
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MRCKG_MOUSE
NC score	0.829634 (rank : 300)	θ value	5.8054e-15 (rank : 358)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1466	Shared Neighborhood Hits	1050
SwissProt Accessions	Q80UW5	Gene names	Cdc42bpg
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1) (CDC42- binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma).

MASTL_MOUSE
NC score	0.829614 (rank : 301)	θ value	6.21693e-09 (rank : 579)
Query Neighborhood Hits	1580	Target Neighborhood Hits	862	Shared Neighborhood Hits	809
SwissProt Accessions	Q8C0P0, Q5RJW0, Q6NXX9, Q8BVF3, Q9CZH9, Q9D9V0	Gene names	Mastl
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase-like (EC 2.7.11.1).

CDKL1_MOUSE
NC score	0.829125 (rank : 302)	θ value	8.10077e-17 (rank : 299)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	799
SwissProt Accessions	Q8CEQ0	Gene names	Cdkl1
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22).

PDK1L_HUMAN
NC score	0.828935 (rank : 303)	θ value	5.81887e-07 (rank : 684)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	790
SwissProt Accessions	Q8N165, Q5T2I0, Q8NDB3	Gene names	PDIK1L, CLIK1L
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

PDK1L_MOUSE
NC score	0.828770 (rank : 304)	θ value	5.81887e-07 (rank : 685)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	791
SwissProt Accessions	Q8QZR7, Q3URF0, Q8BKB3	Gene names	Pdik1l
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1- interacting kinase 1-like).

E2AK2_MOUSE
NC score	0.828611 (rank : 305)	θ value	1.17247e-07 (rank : 640)
Query Neighborhood Hits	1580	Target Neighborhood Hits	864	Shared Neighborhood Hits	812
SwissProt Accessions	Q03963, Q61742, Q62026	Gene names	Eif2ak2, Pkr, Prkr, Tik
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase) (Serine/threonine-protein kinase TIK).

CDKL1_HUMAN
NC score	0.828480 (rank : 306)	θ value	4.02038e-16 (rank : 319)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	801
SwissProt Accessions	Q00532, Q6QUA0	Gene names	CDKL1
Domain Architecture
Description	Cyclin-dependent kinase-like 1 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIALRE) (Protein kinase p42 KKIALRE).

YSK4_HUMAN
NC score	0.827451 (rank : 307)	θ value	1.99529e-15 (rank : 343)
Query Neighborhood Hits	1580	Target Neighborhood Hits	921	Shared Neighborhood Hits	817
SwissProt Accessions	Q56UN5, Q56UN1, Q56UN2, Q56UN3, Q56UN4, Q8N4E9, Q9H5T2	Gene names	YSK4, RCK
Domain Architecture	No domain graphic available
Description	SPS1/STE20-related protein kinase YSK4 (EC 2.7.11.1) (Regulated in COPD, protein kinase).

F5006_MOUSE
NC score	0.827441 (rank : 308)	θ value	1.53129e-07 (rank : 652)
Query Neighborhood Hits	1580	Target Neighborhood Hits	793	Shared Neighborhood Hits	767
SwissProt Accessions	Q5SYL1	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

CDKL4_MOUSE
NC score	0.826722 (rank : 309)	θ value	9.56915e-18 (rank : 274)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	801
SwissProt Accessions	Q3TZA2	Gene names	Cdkl4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

OXSR1_MOUSE
NC score	0.826682 (rank : 310)	θ value	1.80466e-16 (rank : 312)
Query Neighborhood Hits	1580	Target Neighborhood Hits	865	Shared Neighborhood Hits	815
SwissProt Accessions	Q6P9R2, Q8BVZ9, Q8C0B9	Gene names	Oxsr1, Osr1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK40_HUMAN
NC score	0.826664 (rank : 311)	θ value	2.13673e-09 (rank : 555)
Query Neighborhood Hits	1580	Target Neighborhood Hits	751	Shared Neighborhood Hits	729
SwissProt Accessions	Q8N2I9, Q5VTK8, Q5VTK9, Q6ZMN1, Q8N2J8, Q8N3I6, Q96HN6, Q96I44, Q9BSA3, Q9H7H6	Gene names	STK40, SHIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase).

OXSR1_HUMAN
NC score	0.826562 (rank : 312)	θ value	1.058e-16 (rank : 303)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	816
SwissProt Accessions	O95747, Q3LR53, Q7Z501, Q9UPQ1	Gene names	OXSR1, KIAA1101, OSR1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress- responsive 1 protein).

STK40_MOUSE
NC score	0.826416 (rank : 313)	θ value	2.13673e-09 (rank : 556)
Query Neighborhood Hits	1580	Target Neighborhood Hits	751	Shared Neighborhood Hits	729
SwissProt Accessions	Q7TNL3, Q3U3G3, Q811D6, Q8BKT1, Q9D7K3	Gene names	Stk40, Lyk4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 40 (EC 2.7.11.1) (Serine/threonine- protein kinase lyk4).

CDKL2_MOUSE
NC score	0.826030 (rank : 314)	θ value	4.02038e-16 (rank : 320)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	803
SwissProt Accessions	Q9QUK0, Q3UL60, Q3V3X7, Q9QYI1, Q9QYI2	Gene names	Cdkl2, Kkiamre, Kkm
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE).

STK39_MOUSE
NC score	0.825819 (rank : 315)	θ value	4.44505e-15 (rank : 354)
Query Neighborhood Hits	1580	Target Neighborhood Hits	915	Shared Neighborhood Hits	824
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

MP2K2_HUMAN
NC score	0.825746 (rank : 316)	θ value	2.88119e-14 (rank : 378)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	804
SwissProt Accessions	P36507	Gene names	MAP2K2, MEK2, MKK2, PRKMK2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

M3K8_HUMAN
NC score	0.825725 (rank : 317)	θ value	7.84624e-12 (rank : 449)
Query Neighborhood Hits	1580	Target Neighborhood Hits	807	Shared Neighborhood Hits	785
SwissProt Accessions	P41279, Q14275, Q9HC81	Gene names	MAP3K8, COT
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

STK39_HUMAN
NC score	0.825644 (rank : 318)	θ value	4.44505e-15 (rank : 353)
Query Neighborhood Hits	1580	Target Neighborhood Hits	882	Shared Neighborhood Hits	820
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

M3K8_MOUSE
NC score	0.825614 (rank : 319)	θ value	5.08577e-11 (rank : 476)
Query Neighborhood Hits	1580	Target Neighborhood Hits	815	Shared Neighborhood Hits	788
SwissProt Accessions	Q07174	Gene names	Map3k8, Cot
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COT proto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osaka thyroid oncogene).

MP2K1_HUMAN
NC score	0.825354 (rank : 320)	θ value	1.52774e-15 (rank : 336)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	801
SwissProt Accessions	Q02750	Gene names	MAP2K1, MEK1, PRKMK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

STK3_MOUSE
NC score	0.825282 (rank : 321)	θ value	3.07829e-16 (rank : 318)
Query Neighborhood Hits	1580	Target Neighborhood Hits	869	Shared Neighborhood Hits	818
SwissProt Accessions	Q9JI10, Q60877, Q80UG4, Q8CI58	Gene names	Stk3, Mess1, Mst2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2).

CDKL2_HUMAN
NC score	0.825172 (rank : 322)	θ value	1.80466e-16 (rank : 310)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	806
SwissProt Accessions	Q92772	Gene names	CDKL2
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Serine/threonine- protein kinase KKIAMRE) (Protein kinase p56 KKIAMRE).

MP2K1_MOUSE
NC score	0.825169 (rank : 323)	θ value	1.99529e-15 (rank : 342)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	801
SwissProt Accessions	P31938	Gene names	Map2k1, Mek1, Prkmk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.12.2) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1).

KPCA_HUMAN
NC score	0.825131 (rank : 324)	θ value	5.99374e-20 (rank : 205)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1070	Shared Neighborhood Hits	821
SwissProt Accessions	P17252, Q15137, Q96RE4	Gene names	PRKCA, PKCA, PRKACA
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

KPCA_MOUSE
NC score	0.825102 (rank : 325)	θ value	2.97466e-19 (rank : 220)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1067	Shared Neighborhood Hits	818
SwissProt Accessions	P20444	Gene names	Prkca, Pkca
Domain Architecture
Description	Protein kinase C alpha type (EC 2.7.11.13) (PKC-alpha) (PKC-A).

STK3_HUMAN
NC score	0.824854 (rank : 326)	θ value	1.16975e-15 (rank : 334)
Query Neighborhood Hits	1580	Target Neighborhood Hits	861	Shared Neighborhood Hits	816
SwissProt Accessions	Q13188, Q15445, Q15801, Q96FM6	Gene names	STK3, MST2
Domain Architecture
Description	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (STE20-like kinase MST2) (MST-2) (Mammalian STE20-like protein kinase 2) (Serine/threonine-protein kinase Krs-1).

STK4_HUMAN
NC score	0.824474 (rank : 327)	θ value	6.20254e-17 (rank : 296)
Query Neighborhood Hits	1580	Target Neighborhood Hits	870	Shared Neighborhood Hits	816
SwissProt Accessions	Q13043, Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4	Gene names	STK4, MST1
Domain Architecture
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1) (Serine/threonine-protein kinase Krs-2).

STK4_MOUSE
NC score	0.824471 (rank : 328)	θ value	4.74913e-17 (rank : 292)
Query Neighborhood Hits	1580	Target Neighborhood Hits	873	Shared Neighborhood Hits	816
SwissProt Accessions	Q9JI11	Gene names	Stk4, Mst1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (STE20-like kinase MST1) (MST-1) (Mammalian STE20-like protein kinase 1).

CDKL4_HUMAN
NC score	0.824461 (rank : 329)	θ value	2.35696e-16 (rank : 313)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	797
SwissProt Accessions	Q5MAI5	Gene names	CDKL4
Domain Architecture	No domain graphic available
Description	Cyclin-dependent kinase-like 4 (EC 2.7.11.22).

F5006_HUMAN
NC score	0.824027 (rank : 330)	θ value	1.53129e-07 (rank : 651)
Query Neighborhood Hits	1580	Target Neighborhood Hits	794	Shared Neighborhood Hits	765
SwissProt Accessions	Q96LW2, Q49A48	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized serine/threonine-protein kinase FLJ25006 (EC 2.7.11.1).

MP2K2_MOUSE
NC score	0.823978 (rank : 331)	θ value	1.09485e-13 (rank : 384)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	803
SwissProt Accessions	Q63932	Gene names	Map2k2, Mek2, Mkk2, Prkmk2
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2) (MAP kinase kinase 2) (MAPKK 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK2).

PMYT1_MOUSE
NC score	0.823298 (rank : 332)	θ value	6.00763e-12 (rank : 442)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	800
SwissProt Accessions	Q9ESG9, Q8R3L4	Gene names	Pkmyt1, Myt1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

STK35_HUMAN
NC score	0.822309 (rank : 333)	θ value	1.63604e-09 (rank : 549)
Query Neighborhood Hits	1580	Target Neighborhood Hits	825	Shared Neighborhood Hits	794
SwissProt Accessions	Q8TDR2, Q5T3R1, Q5T3R2, Q96AB4, Q9BZ06	Gene names	STK35, CLIK1, PDIK1
Domain Architecture
Description	Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase) (Clik1) (PDLIM1-interacting kinase 1).

LATS1_HUMAN
NC score	0.822237 (rank : 334)	θ value	2.7842e-17 (rank : 283)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1057	Shared Neighborhood Hits	845
SwissProt Accessions	O95835, Q6PKD0	Gene names	LATS1, WARTS
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts).

NEK9_HUMAN
NC score	0.821776 (rank : 335)	θ value	1.52774e-15 (rank : 338)
Query Neighborhood Hits	1580	Target Neighborhood Hits	900	Shared Neighborhood Hits	824
SwissProt Accessions	Q8TD19, Q52LK6, Q8NCN0, Q8TCY4, Q9UPI4, Q9Y6S4, Q9Y6S5, Q9Y6S6	Gene names	NEK9, KIAA1995, NEK8, NERCC
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9) (Nercc1 kinase) (NIMA-related kinase 8) (Nek8).

STK24_HUMAN
NC score	0.821728 (rank : 336)	θ value	2.13179e-17 (rank : 281)
Query Neighborhood Hits	1580	Target Neighborhood Hits	853	Shared Neighborhood Hits	815
SwissProt Accessions	Q9Y6E0, O14840	Gene names	STK24, MST3, STK3
Domain Architecture
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3).

NEK9_MOUSE
NC score	0.821475 (rank : 337)	θ value	4.44505e-15 (rank : 352)
Query Neighborhood Hits	1580	Target Neighborhood Hits	890	Shared Neighborhood Hits	820
SwissProt Accessions	Q8K1R7, Q8R3P1	Gene names	Nek9, Nercc
Domain Architecture
Description	Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (NimA-related protein kinase 9) (Never in mitosis A-related kinase 9).

STK24_MOUSE
NC score	0.821179 (rank : 338)	θ value	7.32683e-18 (rank : 272)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	816
SwissProt Accessions	Q99KH8	Gene names	Stk24
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase 24 (EC 2.7.11.1).

STK10_HUMAN
NC score	0.820970 (rank : 339)	θ value	3.07829e-16 (rank : 317)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1921	Shared Neighborhood Hits	1097
SwissProt Accessions	O94804, Q9UIW4	Gene names	STK10, LOK
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CDK3_MOUSE
NC score	0.820802 (rank : 340)	θ value	2.88119e-14 (rank : 376)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	799
SwissProt Accessions	Q80YP0	Gene names	Cdk3
Domain Architecture	No domain graphic available
Description	Truncated cell division protein kinase 3 homolog.

STK25_HUMAN
NC score	0.820414 (rank : 341)	θ value	5.07402e-19 (rank : 230)
Query Neighborhood Hits	1580	Target Neighborhood Hits	853	Shared Neighborhood Hits	812
SwissProt Accessions	O00506, Q15522, Q5BJF1	Gene names	STK25, SOK1, YSK1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

MST4_MOUSE
NC score	0.820408 (rank : 342)	θ value	6.20254e-17 (rank : 295)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	814
SwissProt Accessions	Q99JT2	Gene names	Mst4
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4).

MST4_HUMAN
NC score	0.820304 (rank : 343)	θ value	8.10077e-17 (rank : 301)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	813
SwissProt Accessions	Q9P289, Q3ZB77, Q9BXC4	Gene names	MST4, MASK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MST4 (EC 2.7.11.1) (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase).

KPCG_HUMAN
NC score	0.819962 (rank : 344)	θ value	3.28887e-18 (rank : 257)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1126	Shared Neighborhood Hits	823
SwissProt Accessions	P05129	Gene names	PRKCG, PKCG
Domain Architecture
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

KPCB_MOUSE
NC score	0.819961 (rank : 345)	θ value	3.63628e-17 (rank : 287)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1117	Shared Neighborhood Hits	821
SwissProt Accessions	P68404, P04410, P04411	Gene names	Prkcb1, Pkcb, Prkcb
Domain Architecture	No domain graphic available
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

KPCG_MOUSE
NC score	0.819940 (rank : 346)	θ value	7.32683e-18 (rank : 268)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1123	Shared Neighborhood Hits	822
SwissProt Accessions	P63318, P05697	Gene names	Prkcg, Pkcc, Pkcg, Prkcc
Domain Architecture	No domain graphic available
Description	Protein kinase C gamma type (EC 2.7.11.13) (PKC-gamma).

STK25_MOUSE
NC score	0.819798 (rank : 347)	θ value	1.13037e-18 (rank : 243)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	812
SwissProt Accessions	Q9Z2W1	Gene names	Stk25, Sok1
Domain Architecture
Description	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase).

KPCB_HUMAN
NC score	0.819715 (rank : 348)	θ value	3.63628e-17 (rank : 286)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1121	Shared Neighborhood Hits	821
SwissProt Accessions	P05771, O43744, P05127, Q15138, Q93060, Q9UE49, Q9UE50, Q9UEH8, Q9UJ30, Q9UJ33	Gene names	PRKCB1, PKCB, PRKCB
Domain Architecture
Description	Protein kinase C beta type (EC 2.7.11.13) (PKC-beta) (PKC-B).

LATS1_MOUSE
NC score	0.819646 (rank : 349)	θ value	1.058e-16 (rank : 302)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1027	Shared Neighborhood Hits	834
SwissProt Accessions	Q8BYR2, Q9Z0W4	Gene names	Lats1, Warts
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase).

CDC2_HUMAN
NC score	0.819562 (rank : 350)	θ value	2.27762e-19 (rank : 219)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	809
SwissProt Accessions	P06493, O60764	Gene names	CDC2
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

PMYT1_HUMAN
NC score	0.819201 (rank : 351)	θ value	6.00763e-12 (rank : 441)
Query Neighborhood Hits	1580	Target Neighborhood Hits	814	Shared Neighborhood Hits	778
SwissProt Accessions	Q99640, O14731, Q7LE24, Q8TCM9	Gene names	PKMYT1, MYT1
Domain Architecture	No domain graphic available
Description	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase).

LATS2_MOUSE
NC score	0.819105 (rank : 352)	θ value	1.16975e-15 (rank : 332)
Query Neighborhood Hits	1580	Target Neighborhood Hits	879	Shared Neighborhood Hits	800
SwissProt Accessions	Q7TSJ6, Q8CDJ4, Q9JMI3	Gene names	Lats2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein).

LATS2_HUMAN
NC score	0.819071 (rank : 353)	θ value	1.16975e-15 (rank : 331)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	800
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

CDC2_MOUSE
NC score	0.819036 (rank : 354)	θ value	8.65492e-19 (rank : 236)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	807
SwissProt Accessions	P11440, P70337, Q3TI12	Gene names	Cdc2, Cdc2a
Domain Architecture
Description	Cell division control protein 2 homolog (EC 2.7.11.22) (EC 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1).

MP2K5_MOUSE
NC score	0.817860 (rank : 355)	θ value	2.28291e-11 (rank : 468)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	808
SwissProt Accessions	Q9WVS7, Q8CFM3, Q8K360, Q9D222	Gene names	Map2k5, Mek5, Mkk5, Prkmk5
Domain Architecture	No domain graphic available
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

CDK3_HUMAN
NC score	0.816750 (rank : 356)	θ value	1.33526e-19 (rank : 213)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	807
SwissProt Accessions	Q00526	Gene names	CDK3
Domain Architecture
Description	Cell division protein kinase 3 (EC 2.7.11.22).

M4K3_HUMAN
NC score	0.815787 (rank : 357)	θ value	1.58096e-12 (rank : 417)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	809
SwissProt Accessions	Q8IVH8, Q8IVH7, Q9UDM5, Q9Y6R5	Gene names	MAP4K3
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK).

MP2K7_HUMAN
NC score	0.815415 (rank : 358)	θ value	1.17247e-07 (rank : 643)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	799
SwissProt Accessions	O14733, O14648, O14816, O60452, O60453	Gene names	MAP2K7, JNKK2, MKK7, PRKMK7
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 7 (EC 2.7.12.2) (MAP kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7) (JNK-activating kinase 2) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2).

CDK7_MOUSE
NC score	0.815212 (rank : 359)	θ value	8.65492e-19 (rank : 237)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	798
SwissProt Accessions	Q03147, Q99KK3	Gene names	Cdk7, Cdkn7, Crk4, Mo15, Mpk-7
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (Protein-tyrosine kinase MPK-7) (CR4 protein kinase) (CRK4).

CDK7_HUMAN
NC score	0.815144 (rank : 360)	θ value	1.13037e-18 (rank : 239)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	798
SwissProt Accessions	P50613, Q9BS60, Q9UE19	Gene names	CDK7, MO15
Domain Architecture
Description	Cell division protein kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (CDK- activating kinase) (CAK) (TFIIH basal transcription factor complex kinase subunit) (39 kDa protein kinase) (P39 Mo15) (STK1) (CAK1).

CDK2_HUMAN
NC score	0.814470 (rank : 361)	θ value	6.20254e-17 (rank : 293)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	804
SwissProt Accessions	P24941	Gene names	CDK2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22) (p33 protein kinase).

M4K1_HUMAN
NC score	0.814330 (rank : 362)	θ value	9.90251e-15 (rank : 367)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	816
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

E2AK2_HUMAN
NC score	0.813636 (rank : 363)	θ value	5.44631e-05 (rank : 845)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	806
SwissProt Accessions	P19525	Gene names	EIF2AK2, PKR, PRKR
Domain Architecture
Description	Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Interferon-inducible RNA-dependent protein kinase) (Protein kinase RNA-activated) (PKR) (p68 kinase) (P1/eIF-2A protein kinase).

MP2K5_HUMAN
NC score	0.813374 (rank : 364)	θ value	1.133e-10 (rank : 488)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	804
SwissProt Accessions	Q13163	Gene names	MAP2K5, MEK5, MKK5, PRKMK5
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.12.2) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5).

M4K1_MOUSE
NC score	0.813330 (rank : 365)	θ value	8.38298e-14 (rank : 383)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	810
SwissProt Accessions	P70218, Q8R3R0, Q99K62	Gene names	Map4k1, Hpk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase) (HPK).

PFTK1_MOUSE
NC score	0.813096 (rank : 366)	θ value	1.58096e-12 (rank : 420)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	800
SwissProt Accessions	O35495, O35848	Gene names	Pftk1
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

PFTK1_HUMAN
NC score	0.812752 (rank : 367)	θ value	2.0648e-12 (rank : 428)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	796
SwissProt Accessions	O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0	Gene names	PFTK1, KIAA0834
Domain Architecture
Description	Serine/threonine-protein kinase PFTAIRE-1 (EC 2.7.11.22).

MK15_MOUSE
NC score	0.812337 (rank : 368)	θ value	6.21693e-09 (rank : 581)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	801
SwissProt Accessions	Q80Y86	Gene names	Mapk15, Erk7
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 7).

M4K2_MOUSE
NC score	0.811927 (rank : 369)	θ value	1.63604e-09 (rank : 545)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	806
SwissProt Accessions	Q61161	Gene names	Map4k2, Rab8ip
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GCK) (Rab8-interacting protein).

CDK2_MOUSE
NC score	0.811851 (rank : 370)	θ value	5.25075e-16 (rank : 324)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	800
SwissProt Accessions	P97377, O55105	Gene names	Cdk2
Domain Architecture
Description	Cell division protein kinase 2 (EC 2.7.11.22).

ICK_MOUSE
NC score	0.811756 (rank : 371)	θ value	2.28291e-11 (rank : 465)
Query Neighborhood Hits	1580	Target Neighborhood Hits	860	Shared Neighborhood Hits	810
SwissProt Accessions	Q9JKV2, Q8K138	Gene names	Ick
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK).

MK15_HUMAN
NC score	0.811634 (rank : 372)	θ value	2.43908e-13 (rank : 398)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1038	Shared Neighborhood Hits	812
SwissProt Accessions	Q8TD08, Q2TCF9, Q8N362	Gene names	MAPK15, ERK8
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 15 (EC 2.7.11.24) (Extracellular signal-regulated kinase 8).

PCTK3_MOUSE
NC score	0.811581 (rank : 373)	θ value	5.8054e-15 (rank : 361)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	798
SwissProt Accessions	Q04899	Gene names	Pctk3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

M4K2_HUMAN
NC score	0.811449 (rank : 374)	θ value	3.64472e-09 (rank : 565)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	808
SwissProt Accessions	Q12851	Gene names	MAP4K2, GCK, RAB8IP
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Germinal center kinase) (GC kinase) (Rab8-interacting protein) (B lymphocyte serine/threonine-protein kinase).

ICK_HUMAN
NC score	0.810913 (rank : 375)	θ value	2.28291e-11 (rank : 464)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	807
SwissProt Accessions	Q9UPZ9, O75985, Q5THL2, Q8IYH8, Q9BX17, Q9NYX3	Gene names	ICK, KIAA0936
Domain Architecture
Description	Serine/threonine-protein kinase ICK (EC 2.7.11.22) (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2).

TNIK_HUMAN
NC score	0.810884 (rank : 376)	θ value	1.47974e-10 (rank : 492)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1570	Shared Neighborhood Hits	1032
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

MAK_MOUSE
NC score	0.810574 (rank : 377)	θ value	1.42992e-13 (rank : 390)
Query Neighborhood Hits	1580	Target Neighborhood Hits	873	Shared Neighborhood Hits	806
SwissProt Accessions	Q04859	Gene names	Mak, Rck
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase) (Protein kinase RCK).

ROCK2_HUMAN
NC score	0.810514 (rank : 378)	θ value	3.88503e-19 (rank : 225)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2073	Shared Neighborhood Hits	1093
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

PCTK1_HUMAN
NC score	0.810353 (rank : 379)	θ value	5.8054e-15 (rank : 359)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	799
SwissProt Accessions	Q00536	Gene names	PCTK1
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1).

PCTK1_MOUSE
NC score	0.810032 (rank : 380)	θ value	5.8054e-15 (rank : 360)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	798
SwissProt Accessions	Q04735	Gene names	Pctk1, Crk5
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-1 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 1) (CRK5).

PCTK3_HUMAN
NC score	0.809440 (rank : 381)	θ value	1.52774e-15 (rank : 339)
Query Neighborhood Hits	1580	Target Neighborhood Hits	827	Shared Neighborhood Hits	795
SwissProt Accessions	Q07002, Q5VXQ2, Q96F90	Gene names	PCTK3
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 3).

CTRO_HUMAN
NC score	0.809363 (rank : 382)	θ value	1.09232e-21 (rank : 170)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2092	Shared Neighborhood Hits	1103
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

MAK_HUMAN
NC score	0.809036 (rank : 383)	θ value	2.0648e-12 (rank : 427)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	802
SwissProt Accessions	P20794, Q9NUH7	Gene names	MAK
Domain Architecture
Description	Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male germ cell- associated kinase).

MK12_MOUSE
NC score	0.808629 (rank : 384)	θ value	1.58096e-12 (rank : 418)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	800
SwissProt Accessions	O08911, Q9D0M4	Gene names	Mapk12, Sapk3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

GSK3A_HUMAN
NC score	0.808601 (rank : 385)	θ value	2.28291e-11 (rank : 463)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	783
SwissProt Accessions	P49840, O14959	Gene names	GSK3A
Domain Architecture
Description	Glycogen synthase kinase-3 alpha (EC 2.7.11.26) (GSK-3 alpha).

MK12_HUMAN
NC score	0.807837 (rank : 386)	θ value	3.52202e-12 (rank : 436)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	799
SwissProt Accessions	P53778, Q14260, Q99588, Q99672	Gene names	MAPK12, ERK6, SAPK3
Domain Architecture
Description	Mitogen-activated protein kinase 12 (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (ERK5) (Stress-activated protein kinase 3) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma).

MRCKA_HUMAN
NC score	0.807828 (rank : 387)	θ value	6.85773e-16 (rank : 329)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1999	Shared Neighborhood Hits	1104
SwissProt Accessions	Q5VT25, Q59GZ1, Q5H9N9, Q5T797, Q5VT26, Q5VT27, Q86XX2, Q86XX3, Q99646	Gene names	CDC42BPA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1) (CDC42- binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) (DMPK-like alpha).

MP2K4_HUMAN
NC score	0.807427 (rank : 388)	θ value	1.17247e-07 (rank : 641)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	805
SwissProt Accessions	P45985, Q5U0B8	Gene names	MAP2K4, JNKK1, MKK4, PRKMK4, SERK1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (JNK-activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1).

MP2K4_MOUSE
NC score	0.807272 (rank : 389)	θ value	1.17247e-07 (rank : 642)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	805
SwissProt Accessions	P47809	Gene names	Map2k4, Jnkk1, Prkmk4, Sek1, Serk1
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (MAP kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4) (JNK-activating kinase 1) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1) (SEK1).

ROCK1_HUMAN
NC score	0.807248 (rank : 390)	θ value	1.5773e-20 (rank : 193)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2000	Shared Neighborhood Hits	1096
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

MINK1_MOUSE
NC score	0.807246 (rank : 391)	θ value	1.9326e-10 (rank : 497)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1451	Shared Neighborhood Hits	1018
SwissProt Accessions	Q9JM52, Q921M6, Q9JM92	Gene names	Mink1, Map4k6, Mink
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

M4K5_MOUSE
NC score	0.807155 (rank : 392)	θ value	3.29651e-10 (rank : 509)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	797
SwissProt Accessions	Q8BPM2, Q6PEQ2, Q8C3U5, Q8CGF3, Q99LM7, Q9CX73	Gene names	Map4k5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).

CSK21_MOUSE
NC score	0.806991 (rank : 393)	θ value	1.58096e-12 (rank : 416)
Query Neighborhood Hits	1580	Target Neighborhood Hits	770	Shared Neighborhood Hits	747
SwissProt Accessions	Q60737	Gene names	Csnk2a1, Ckiia
Domain Architecture
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

PCTK2_HUMAN
NC score	0.806972 (rank : 394)	θ value	4.02038e-16 (rank : 322)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	796
SwissProt Accessions	Q00537, Q8NEB8	Gene names	PCTK2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

MINK1_HUMAN
NC score	0.806924 (rank : 395)	θ value	1.9326e-10 (rank : 496)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1477	Shared Neighborhood Hits	1029
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

CSK21_HUMAN
NC score	0.806556 (rank : 396)	θ value	1.58096e-12 (rank : 415)
Query Neighborhood Hits	1580	Target Neighborhood Hits	772	Shared Neighborhood Hits	747
SwissProt Accessions	P68400, P19138, P20426, Q14013	Gene names	CSNK2A1, CK2A1
Domain Architecture	No domain graphic available
Description	Casein kinase II subunit alpha (EC 2.7.11.1) (CK II).

PCTK2_MOUSE
NC score	0.806555 (rank : 397)	θ value	2.60593e-15 (rank : 347)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	796
SwissProt Accessions	Q8K0D0	Gene names	Pctk2
Domain Architecture
Description	Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22) (PCTAIRE- motif protein kinase 2).

ROCK2_MOUSE
NC score	0.806541 (rank : 398)	θ value	1.13037e-18 (rank : 240)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2072	Shared Neighborhood Hits	1095
SwissProt Accessions	P70336, Q8BR64, Q8CBR0	Gene names	Rock2
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2).

GSK3B_HUMAN
NC score	0.806203 (rank : 399)	θ value	9.59137e-10 (rank : 530)
Query Neighborhood Hits	1580	Target Neighborhood Hits	801	Shared Neighborhood Hits	777
SwissProt Accessions	P49841, Q9BWH3, Q9UL47	Gene names	GSK3B
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

GSK3B_MOUSE
NC score	0.806200 (rank : 400)	θ value	9.59137e-10 (rank : 531)
Query Neighborhood Hits	1580	Target Neighborhood Hits	800	Shared Neighborhood Hits	776
SwissProt Accessions	Q9WV60	Gene names	Gsk3b
Domain Architecture
Description	Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

M4K5_HUMAN
NC score	0.806040 (rank : 401)	θ value	4.30538e-10 (rank : 513)
Query Neighborhood Hits	1580	Target Neighborhood Hits	845	Shared Neighborhood Hits	800
SwissProt Accessions	Q9Y4K4, Q8IYF6	Gene names	MAP4K5
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS).

TAOK2_MOUSE
NC score	0.806019 (rank : 402)	θ value	6.00763e-12 (rank : 447)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1373	Shared Neighborhood Hits	1030
SwissProt Accessions	Q6ZQ29, Q7TSS8	Gene names	Taok2, Kiaa0881
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2).

TAOK2_HUMAN
NC score	0.805871 (rank : 403)	θ value	6.00763e-12 (rank : 446)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1172	Shared Neighborhood Hits	969
SwissProt Accessions	Q9UL54, O94957, Q6UW73, Q7LC09, Q9NSW2	Gene names	TAOK2, KIAA0881, MAP3K17, PSK, PSK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Thousand and one amino acid protein 2) (Prostate-derived STE20-like kinase 1) (PSK-1) (Kinase from chicken homolog C) (hKFC-C).

HIPK4_HUMAN
NC score	0.805671 (rank : 404)	θ value	5.43371e-13 (rank : 403)
Query Neighborhood Hits	1580	Target Neighborhood Hits	799	Shared Neighborhood Hits	766
SwissProt Accessions	Q8NE63	Gene names	HIPK4
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 4 (EC 2.7.11.1).

MK14_MOUSE
NC score	0.805670 (rank : 405)	θ value	1.58096e-12 (rank : 419)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	805
SwissProt Accessions	P47811, O08666, Q3UZS3, Q8C289, Q9JLV8, Q9QZ80	Gene names	Mapk14, Crk1, Csbp1, Csbp2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (CRK1).

CCRK_HUMAN
NC score	0.805573 (rank : 406)	θ value	7.34386e-10 (rank : 523)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	803
SwissProt Accessions	Q8IZL9, Q5EDC4, Q5VYW1, Q9BUF4	Gene names	CCRK, CDCH
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (Cyclin- dependent protein kinase H).

MK14_HUMAN
NC score	0.805503 (rank : 407)	θ value	2.69671e-12 (rank : 430)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	805
SwissProt Accessions	Q16539, O60776, Q13083, Q14084, Q8TDX0	Gene names	MAPK14, CSBP, CSBP1, CSBP2, MXI2
Domain Architecture
Description	Mitogen-activated protein kinase 14 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAX-interacting protein 2) (MAP kinase MXI2) (SAPK2A).

CDK5_HUMAN
NC score	0.805401 (rank : 408)	θ value	1.133e-10 (rank : 486)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	793
SwissProt Accessions	Q00535	Gene names	CDK5
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE).

CDK6_MOUSE
NC score	0.805292 (rank : 409)	θ value	1.42992e-13 (rank : 386)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	804
SwissProt Accessions	Q64261, Q9R1D2, Q9R1D3	Gene names	Cdk6, Crk2
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE) (CRK2).

STK10_MOUSE
NC score	0.805208 (rank : 410)	θ value	4.02038e-16 (rank : 323)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2132	Shared Neighborhood Hits	1104
SwissProt Accessions	O55098	Gene names	Stk10, Lok
Domain Architecture
Description	Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase).

CDK5_MOUSE
NC score	0.805190 (rank : 411)	θ value	1.133e-10 (rank : 487)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	793
SwissProt Accessions	P49615	Gene names	Cdk5, Crk6
Domain Architecture
Description	Cell division protein kinase 5 (EC 2.7.11.22) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6).

CCRK_MOUSE
NC score	0.804874 (rank : 412)	θ value	2.79066e-09 (rank : 558)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	801
SwissProt Accessions	Q9JHU3, Q5EDC2	Gene names	Ccrk, Cdch
Domain Architecture	No domain graphic available
Description	Cell cycle-related kinase (EC 2.7.11.22) (Cyclin-kinase-activating kinase p42) (CDK-activating kinase p42) (CAK-kinase p42) (CDK-related protein kinase PNQLARE) (Cyclin-dependent protein kinase H).

CDK6_HUMAN
NC score	0.804761 (rank : 413)	θ value	2.43908e-13 (rank : 394)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	804
SwissProt Accessions	Q00534	Gene names	CDK6
Domain Architecture
Description	Cell division protein kinase 6 (EC 2.7.11.22) (Serine/threonine- protein kinase PLSTIRE).

MK13_MOUSE
NC score	0.804756 (rank : 414)	θ value	1.33837e-11 (rank : 458)
Query Neighborhood Hits	1580	Target Neighborhood Hits	832	Shared Neighborhood Hits	801
SwissProt Accessions	Q9Z1B7, Q99M57	Gene names	Mapk13, Serk4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

MK09_HUMAN
NC score	0.804657 (rank : 415)	θ value	6.64225e-11 (rank : 481)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	808
SwissProt Accessions	P45984, Q15708, Q15710, Q15711, Q8N5C5	Gene names	MAPK9, JNK2, PRKM9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2) (JNK-55).

MP2K3_MOUSE
NC score	0.803270 (rank : 416)	θ value	7.1131e-05 (rank : 854)
Query Neighborhood Hits	1580	Target Neighborhood Hits	826	Shared Neighborhood Hits	799
SwissProt Accessions	O09110, P97293, Q91VX1	Gene names	Map2k3, Mkk3, Prkmk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MK13_HUMAN
NC score	0.803171 (rank : 417)	θ value	2.98157e-11 (rank : 471)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	800
SwissProt Accessions	O15264, O14739, O15124, Q9UNU0	Gene names	MAPK13, PRKM13, SAPK4
Domain Architecture
Description	Mitogen-activated protein kinase 13 (EC 2.7.11.24) (Stress-activated protein kinase 4) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta).

TAOK3_HUMAN
NC score	0.802854 (rank : 418)	θ value	7.09661e-13 (rank : 406)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1494	Shared Neighborhood Hits	1032
SwissProt Accessions	Q9H2K8, Q658N1, Q8IUM4, Q9HC79, Q9NZM9, Q9UHG7	Gene names	TAOK3, DPK, JIK, KDS, MAP3K18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3) (Jun kinase-inhibitory kinase) (JNK/SAPK- inhibitory kinase) (Dendritic cell-derived protein kinase) (Cutaneous T-cell lymphoma tumor antigen HD-CL-09) (CTCL tumor antigen HD-CL-09) (Kinase from chicken homolog A) (hKFC-A).

STK16_HUMAN
NC score	0.802806 (rank : 419)	θ value	0.21417 (rank : 1180)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	796
SwissProt Accessions	O75716, Q96KI2, Q9UEN3, Q9UP78	Gene names	STK16, MPSK1, PKL12, TSF1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK).

TAOK3_MOUSE
NC score	0.802706 (rank : 420)	θ value	3.18553e-13 (rank : 400)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1458	Shared Neighborhood Hits	1031
SwissProt Accessions	Q8BYC6, Q3V3B3	Gene names	Taok3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Thousand and one amino acid protein 3).

M4K4_HUMAN
NC score	0.802516 (rank : 421)	θ value	1.63604e-09 (rank : 546)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1589	Shared Neighborhood Hits	1047
SwissProt Accessions	O95819, O75172, Q9NST7	Gene names	MAP4K4, HGK, KIAA0687, NIK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

NRK_HUMAN
NC score	0.802503 (rank : 422)	θ value	5.62301e-10 (rank : 521)
Query Neighborhood Hits	1580	Target Neighborhood Hits	931	Shared Neighborhood Hits	823
SwissProt Accessions	Q7Z2Y5, Q32ND6, Q5H9K2, Q6ZMP2	Gene names	NRK
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1).

STK16_MOUSE
NC score	0.802313 (rank : 423)	θ value	0.0113563 (rank : 1040)
Query Neighborhood Hits	1580	Target Neighborhood Hits	824	Shared Neighborhood Hits	791
SwissProt Accessions	O88697, Q9JMJ0, Q9JMJ1, Q9QX00	Gene names	Stk16, Edpk, Krct, Mpsk1, Pkl12, Tsf1
Domain Architecture
Description	Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct).

DAPK1_HUMAN
NC score	0.801465 (rank : 424)	θ value	1.15626e-55 (rank : 5)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1130	Shared Neighborhood Hits	816
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

MP2K3_HUMAN
NC score	0.801064 (rank : 425)	θ value	9.29e-05 (rank : 865)
Query Neighborhood Hits	1580	Target Neighborhood Hits	825	Shared Neighborhood Hits	799
SwissProt Accessions	P46734, Q99441, Q9UE71, Q9UE72	Gene names	MAP2K3, MEK3, MKK3, PRKMK3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 3 (EC 2.7.12.2) (MAP kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3).

MK11_MOUSE
NC score	0.800739 (rank : 426)	θ value	3.52202e-12 (rank : 435)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	801
SwissProt Accessions	Q9WUI1	Gene names	Mapk11, Prkm11
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38B).

WNK3_HUMAN
NC score	0.800528 (rank : 427)	θ value	5.08577e-11 (rank : 479)
Query Neighborhood Hits	1580	Target Neighborhood Hits	948	Shared Neighborhood Hits	771
SwissProt Accessions	Q9BYP7, Q9HCK6	Gene names	WNK3, KIAA1566, PRKWNK3
Domain Architecture
Description	Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase with no lysine 3) (Protein kinase, lysine-deficient 3).

MK09_MOUSE
NC score	0.800163 (rank : 428)	θ value	2.52405e-10 (rank : 503)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	806
SwissProt Accessions	Q9WTU6, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5	Gene names	Mapk9, Jnk2, Prkm9
Domain Architecture
Description	Mitogen-activated protein kinase 9 (EC 2.7.11.24) (Stress-activated protein kinase JNK2) (c-Jun N-terminal kinase 2).

MK08_MOUSE
NC score	0.800144 (rank : 429)	θ value	7.84624e-12 (rank : 452)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	805
SwissProt Accessions	Q91Y86	Gene names	Mapk8, Jnk1, Prkm8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1).

NRK_MOUSE
NC score	0.800039 (rank : 430)	θ value	1.80886e-08 (rank : 603)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	818
SwissProt Accessions	Q9R0G8, Q6NV55, Q8C9S9, Q9R0S4	Gene names	Nrk, Nesk
Domain Architecture	No domain graphic available
Description	Nik-related protein kinase (EC 2.7.11.1) (Nck-interacting kinase-like embryo specific kinase) (NIK-like embryo-specific kinase) (NESK).

E2AK1_MOUSE
NC score	0.799977 (rank : 431)	θ value	5.81887e-07 (rank : 677)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	793
SwissProt Accessions	Q9Z2R9, Q8C024, Q8K123, Q9CTP5, Q9D601	Gene names	Eif2ak1, Hri
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

AL2S7_HUMAN
NC score	0.799812 (rank : 432)	θ value	3.08544e-08 (rank : 610)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	795
SwissProt Accessions	Q96Q40, Q4ZG86, Q53TV1	Gene names	ALS2CR7
Domain Architecture
Description	Serine/threonine-protein kinase ALS2CR7 (EC 2.7.11.22) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein).

MK08_HUMAN
NC score	0.799553 (rank : 433)	θ value	7.84624e-12 (rank : 451)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	805
SwissProt Accessions	P45983, Q15709, Q15712, Q15713	Gene names	MAPK8, JNK1, PRKM8
Domain Architecture
Description	Mitogen-activated protein kinase 8 (EC 2.7.11.24) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1) (JNK-46).

MP2K6_MOUSE
NC score	0.799286 (rank : 434)	θ value	0.000270298 (rank : 903)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	803
SwissProt Accessions	P70236	Gene names	Map2k6, Prkmk6, Sapkk3
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

CSK22_MOUSE
NC score	0.799158 (rank : 435)	θ value	7.84624e-12 (rank : 448)
Query Neighborhood Hits	1580	Target Neighborhood Hits	758	Shared Neighborhood Hits	739
SwissProt Accessions	O54833	Gene names	Csnk2a2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

CSK22_HUMAN
NC score	0.799126 (rank : 436)	θ value	1.02475e-11 (rank : 453)
Query Neighborhood Hits	1580	Target Neighborhood Hits	758	Shared Neighborhood Hits	739
SwissProt Accessions	P19784	Gene names	CSNK2A2, CK2A2
Domain Architecture
Description	Casein kinase II subunit alpha' (EC 2.7.11.1) (CK II).

DYRK2_HUMAN
NC score	0.798643 (rank : 437)	θ value	1.2105e-12 (rank : 413)
Query Neighborhood Hits	1580	Target Neighborhood Hits	799	Shared Neighborhood Hits	766
SwissProt Accessions	Q92630	Gene names	DYRK2
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1).

ERN1_HUMAN
NC score	0.798475 (rank : 438)	θ value	2.61198e-07 (rank : 660)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	796
SwissProt Accessions	O75460	Gene names	ERN1, IRE1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (hIRE1p) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

NLK_MOUSE
NC score	0.798285 (rank : 439)	θ value	2.69671e-12 (rank : 432)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	806
SwissProt Accessions	O54949, Q6PF98	Gene names	Nlk
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase).

NLK_HUMAN
NC score	0.798257 (rank : 440)	θ value	2.69671e-12 (rank : 431)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	806
SwissProt Accessions	Q9UBE8, Q2PNI9, Q6P2A3	Gene names	NLK, LAK1
Domain Architecture	No domain graphic available
Description	Serine/threonine kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1).

MP2K6_HUMAN
NC score	0.798188 (rank : 441)	θ value	2.44474e-05 (rank : 824)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	802
SwissProt Accessions	P52564	Gene names	MAP2K6, MEK6, MKK6, PRKMK6
Domain Architecture
Description	Dual specificity mitogen-activated protein kinase kinase 6 (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3).

MOK_HUMAN
NC score	0.798157 (rank : 442)	θ value	1.63604e-09 (rank : 547)
Query Neighborhood Hits	1580	Target Neighborhood Hits	807	Shared Neighborhood Hits	777
SwissProt Accessions	Q9UQ07, Q92790, Q93067	Gene names	RAGE, MOK, RAGE1
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase) (Renal tumor antigen 1) (RAGE-1).

TAOK1_MOUSE
NC score	0.797720 (rank : 443)	θ value	6.00763e-12 (rank : 445)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1720	Shared Neighborhood Hits	1071
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK1_HUMAN
NC score	0.797500 (rank : 444)	θ value	1.02475e-11 (rank : 456)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1734	Shared Neighborhood Hits	1074
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

MK10_HUMAN
NC score	0.797398 (rank : 445)	θ value	1.74796e-11 (rank : 462)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	805
SwissProt Accessions	P53779, Q15707	Gene names	MAPK10, JNK3, JNK3A, PRKM10
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

DAPK1_MOUSE
NC score	0.797364 (rank : 446)	θ value	1.66964e-54 (rank : 8)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1138	Shared Neighborhood Hits	817
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

ERN1_MOUSE
NC score	0.797323 (rank : 447)	θ value	1.69304e-06 (rank : 723)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	793
SwissProt Accessions	Q9EQY0, Q9D340	Gene names	Ern1, Ire1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE1 precursor (Inositol-requiring protein 1) (IRE1a) (Ire1-alpha) (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

MK04_HUMAN
NC score	0.797138 (rank : 448)	θ value	6.87365e-08 (rank : 629)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	797
SwissProt Accessions	P31152	Gene names	MAPK4, ERK4, PRKM4
Domain Architecture
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63- MAPK).

MRCKB_MOUSE
NC score	0.796865 (rank : 449)	θ value	1.92812e-18 (rank : 247)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2180	Shared Neighborhood Hits	1115
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

MK10_MOUSE
NC score	0.796862 (rank : 450)	θ value	2.98157e-11 (rank : 470)
Query Neighborhood Hits	1580	Target Neighborhood Hits	849	Shared Neighborhood Hits	806
SwissProt Accessions	Q61831, Q9R0U6	Gene names	Mapk10, Jnk3, Prkm10, Serk2
Domain Architecture
Description	Mitogen-activated protein kinase 10 (EC 2.7.11.24) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12).

MOK_MOUSE
NC score	0.796818 (rank : 451)	θ value	4.30538e-10 (rank : 514)
Query Neighborhood Hits	1580	Target Neighborhood Hits	796	Shared Neighborhood Hits	774
SwissProt Accessions	Q9WVS4, Q8CFU4	Gene names	Rage, Mok
Domain Architecture
Description	MAPK/MAK/MRK overlapping kinase (EC 2.7.11.22) (MOK protein kinase).

MK04_MOUSE
NC score	0.796648 (rank : 452)	θ value	1.25267e-09 (rank : 542)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	793
SwissProt Accessions	Q6P5G0	Gene names	Mapk4, Erk4, Prkm4
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 4 (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4).

DYRK3_HUMAN
NC score	0.796605 (rank : 453)	θ value	7.34386e-10 (rank : 524)
Query Neighborhood Hits	1580	Target Neighborhood Hits	798	Shared Neighborhood Hits	772
SwissProt Accessions	O43781	Gene names	DYRK3
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 3 (EC 2.7.12.1).

MK03_MOUSE
NC score	0.796590 (rank : 454)	θ value	9.59137e-10 (rank : 533)
Query Neighborhood Hits	1580	Target Neighborhood Hits	840	Shared Neighborhood Hits	803
SwissProt Accessions	Q63844, Q61531, Q8K0X5, Q91YW5	Gene names	Mapk3, Erk1, Prkm3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase) (MNK1).

MK07_MOUSE
NC score	0.796382 (rank : 455)	θ value	7.84624e-12 (rank : 450)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1054	Shared Neighborhood Hits	839
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MK03_HUMAN
NC score	0.796308 (rank : 456)	θ value	7.34386e-10 (rank : 528)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	803
SwissProt Accessions	P27361	Gene names	MAPK3, ERK1, PRKM3
Domain Architecture
Description	Mitogen-activated protein kinase 3 (EC 2.7.11.24) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase 1) (MAPK 1) (p44-ERK1) (ERT2) (p44-MAPK) (Microtubule- associated protein 2 kinase).

CD2L7_HUMAN
NC score	0.795946 (rank : 457)	θ value	1.99992e-07 (rank : 656)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1275	Shared Neighborhood Hits	871
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

MK07_HUMAN
NC score	0.795789 (rank : 458)	θ value	1.02475e-11 (rank : 455)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1087	Shared Neighborhood Hits	849
SwissProt Accessions	Q13164, Q16634	Gene names	MAPK7, ERK4, ERK5, PRKM7
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (ERK4) (BMK1 kinase).

ROCK1_MOUSE
NC score	0.795448 (rank : 459)	θ value	1.5773e-20 (rank : 194)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2126	Shared Neighborhood Hits	1102
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

E2AK1_HUMAN
NC score	0.795335 (rank : 460)	θ value	4.0297e-08 (rank : 619)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	800
SwissProt Accessions	Q9BQI3, Q8NBW3, Q9HC02, Q9NYE0, Q9P0V6, Q9P1J5, Q9P2H8, Q9UHG4	Gene names	EIF2AK1, HRI, KIAA1369
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (Heme-controlled repressor) (HCR) (Hemin-sensitive initiation factor 2-alpha kinase).

CD2L5_HUMAN
NC score	0.794669 (rank : 461)	θ value	7.59969e-07 (rank : 690)
Query Neighborhood Hits	1580	Target Neighborhood Hits	987	Shared Neighborhood Hits	815
SwissProt Accessions	Q14004, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4	Gene names	CDC2L5, CDC2L, CHED, KIAA1791
Domain Architecture
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5) (Cholinesterase-related cell division controller).

CDK4_MOUSE
NC score	0.794513 (rank : 462)	θ value	2.79066e-09 (rank : 559)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	802
SwissProt Accessions	P30285	Gene names	Cdk4, Crk3
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3) (CRK3).

MK01_HUMAN
NC score	0.794474 (rank : 463)	θ value	4.76016e-09 (rank : 572)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	801
SwissProt Accessions	P28482	Gene names	MAPK1, ERK2, PRKM1
Domain Architecture
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

MK01_MOUSE
NC score	0.794334 (rank : 464)	θ value	6.21693e-09 (rank : 580)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	801
SwissProt Accessions	P63085, P27703, Q3V1U6	Gene names	Mapk1, Erk2, Mapk, Prkm1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase 1 (EC 2.7.11.24) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1).

CD2L5_MOUSE
NC score	0.794260 (rank : 465)	θ value	7.59969e-07 (rank : 691)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1011	Shared Neighborhood Hits	813
SwissProt Accessions	Q69ZA1, Q80V11, Q8BZG1, Q8K0A4	Gene names	Cdc2l5, Kiaa1791
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 5 (EC 2.7.11.22) (CDC2- related protein kinase 5).

CTRO_MOUSE
NC score	0.794173 (rank : 466)	θ value	1.86321e-21 (rank : 172)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2344	Shared Neighborhood Hits	1128
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

M4K4_MOUSE
NC score	0.794039 (rank : 467)	θ value	8.11959e-09 (rank : 587)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1560	Shared Neighborhood Hits	1036
SwissProt Accessions	P97820	Gene names	Map4k4, Nik
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase).

CDK4_HUMAN
NC score	0.794005 (rank : 468)	θ value	2.52405e-10 (rank : 500)
Query Neighborhood Hits	1580	Target Neighborhood Hits	834	Shared Neighborhood Hits	800
SwissProt Accessions	P11802, O00576	Gene names	CDK4
Domain Architecture
Description	Cell division protein kinase 4 (EC 2.7.11.22) (Cyclin-dependent kinase 4) (PSK-J3).

E2AK3_HUMAN
NC score	0.793276 (rank : 469)	θ value	0.00228821 (rank : 982)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	803
SwissProt Accessions	Q9NZJ5, O95846	Gene names	EIF2AK3, PEK, PERK
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK).

DYR1B_MOUSE
NC score	0.793174 (rank : 470)	θ value	5.62301e-10 (rank : 519)
Query Neighborhood Hits	1580	Target Neighborhood Hits	799	Shared Neighborhood Hits	761
SwissProt Accessions	Q9Z188	Gene names	Dyrk1b
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1).

MK11_HUMAN
NC score	0.793048 (rank : 471)	θ value	3.29651e-10 (rank : 510)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	798
SwissProt Accessions	Q15759, O00284, O15472, Q2XNF2	Gene names	MAPK11, PRKM11, SAPK2
Domain Architecture
Description	Mitogen-activated protein kinase 11 (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2).

TRIB2_HUMAN
NC score	0.792798 (rank : 472)	θ value	1.69304e-06 (rank : 729)
Query Neighborhood Hits	1580	Target Neighborhood Hits	657	Shared Neighborhood Hits	649
SwissProt Accessions	Q92519	Gene names	TRIB2, TRB2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

ERN2_HUMAN
NC score	0.792603 (rank : 473)	θ value	3.77169e-06 (rank : 748)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	798
SwissProt Accessions	Q76MJ5, Q6ZNC0	Gene names	ERN2, IRE2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (hIRE2p) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

TRIB2_MOUSE
NC score	0.792448 (rank : 474)	θ value	1.69304e-06 (rank : 730)
Query Neighborhood Hits	1580	Target Neighborhood Hits	653	Shared Neighborhood Hits	645
SwissProt Accessions	Q8K4K3, Q8K017, Q8R2V8	Gene names	Trib2
Domain Architecture	No domain graphic available
Description	Tribbles homolog 2 (TRB-2).

MRCKB_HUMAN
NC score	0.791751 (rank : 475)	θ value	6.62687e-19 (rank : 231)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2239	Shared Neighborhood Hits	1119
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

WNK1_HUMAN
NC score	0.791541 (rank : 476)	θ value	5.08577e-11 (rank : 477)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1158	Shared Neighborhood Hits	821
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

CDK10_HUMAN
NC score	0.790054 (rank : 477)	θ value	2.36244e-08 (rank : 604)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	803
SwissProt Accessions	Q15131, Q15130	Gene names	CDK10
Domain Architecture
Description	Cell division protein kinase 10 (EC 2.7.11.22) (Serine/threonine- protein kinase PISSLRE).

E2AK3_MOUSE
NC score	0.790030 (rank : 478)	θ value	0.00102713 (rank : 953)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	808
SwissProt Accessions	Q9Z2B5, Q9CTK8, Q9CWT5	Gene names	Eif2ak3, Pek, Perk
Domain Architecture
Description	Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase).

WNK4_MOUSE
NC score	0.789993 (rank : 479)	θ value	3.64472e-09 (rank : 568)
Query Neighborhood Hits	1580	Target Neighborhood Hits	961	Shared Neighborhood Hits	771
SwissProt Accessions	Q80UE6, Q4VAC1, Q80XB5, Q80XN2, Q8R0N0, Q8R340	Gene names	Wnk4, Prkwnk4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

WNK1_MOUSE
NC score	0.789751 (rank : 480)	θ value	5.08577e-11 (rank : 478)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1179	Shared Neighborhood Hits	809
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

DYR1B_HUMAN
NC score	0.789543 (rank : 481)	θ value	3.29651e-10 (rank : 506)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	763
SwissProt Accessions	Q9Y463, O75258, O75788, O75789	Gene names	DYRK1B, MIRK
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Mirk protein kinase) (Minibrain-related kinase).

ERN2_MOUSE
NC score	0.789382 (rank : 482)	θ value	9.92553e-07 (rank : 707)
Query Neighborhood Hits	1580	Target Neighborhood Hits	825	Shared Neighborhood Hits	792
SwissProt Accessions	Q9Z2E3	Gene names	Ern2, Ire2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase/endoribonuclease IRE2 precursor (Inositol-requiring protein 2) (IRE1b) (Ire1-beta) (Endoplasmic reticulum-to-nucleus signaling 2) (mIre1) [Includes: Serine/threonine- protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)].

BMP2K_MOUSE
NC score	0.788958 (rank : 483)	θ value	1.47974e-10 (rank : 490)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	774
SwissProt Accessions	Q91Z96, Q8C8L7	Gene names	Bmp2k, Bike
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

E2AK4_HUMAN
NC score	0.788763 (rank : 484)	θ value	2.13673e-09 (rank : 554)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1012	Shared Neighborhood Hits	862
SwissProt Accessions	Q9P2K8, Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5, Q9UJ56	Gene names	EIF2AK4, GCN2, KIAA1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein).

CDK9_HUMAN
NC score	0.788646 (rank : 485)	θ value	1.53129e-07 (rank : 648)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	791
SwissProt Accessions	P50750, Q5JU24, Q5JU25, Q5U006, Q96TF1	Gene names	CDK9, CDC2L4
Domain Architecture
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9) (Serine/threonine-protein kinase PITALRE) (C-2K) (Cell division cycle 2-like protein kinase 4).

BMP2K_HUMAN
NC score	0.788621 (rank : 486)	θ value	3.89403e-11 (rank : 474)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	772
SwissProt Accessions	Q9NSY1, O94791, Q8IYF2, Q8N2G7, Q8NHG9, Q9NTG8	Gene names	BMP2K, BIKE
Domain Architecture
Description	BMP-2-inducible protein kinase (EC 2.7.11.1) (BIKe).

CDK9_MOUSE
NC score	0.788034 (rank : 487)	θ value	1.53129e-07 (rank : 649)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	791
SwissProt Accessions	Q99J95, Q3U002, Q3UMY2, Q3UPT3, Q3UQI6, Q8BTN0	Gene names	Cdk9
Domain Architecture	No domain graphic available
Description	Cell division protein kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (Cyclin- dependent kinase 9).

CD2L2_HUMAN
NC score	0.787004 (rank : 488)	θ value	3.19293e-05 (rank : 830)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1439	Shared Neighborhood Hits	970
SwissProt Accessions	Q9UQ88, O95227, O95228, O96012, Q12821, Q12853, Q12854, Q5QPR0, Q5QPR1, Q5QPR2, Q9UBC4, Q9UBI3, Q9UEI1, Q9UEI2, Q9UP53, Q9UP54, Q9UP55, Q9UP56, Q9UQ86, Q9UQ87, Q9UQ89	Gene names	CDC2L2, PITSLREB
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L2 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 2) (CDK11).

CI096_HUMAN
NC score	0.786882 (rank : 489)	θ value	0.00869519 (rank : 1025)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	785
SwissProt Accessions	Q8NE28, Q5T8U8	Gene names	C9orf96
Domain Architecture	No domain graphic available
Description	Protein kinase-like protein C9orf96.

WNK4_HUMAN
NC score	0.786860 (rank : 490)	θ value	4.76016e-09 (rank : 575)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1043	Shared Neighborhood Hits	779
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

HIPK3_MOUSE
NC score	0.786848 (rank : 491)	θ value	5.8054e-15 (rank : 357)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	784
SwissProt Accessions	Q9ERH7, O88906, Q9QZR2	Gene names	Hipk3, Fist3
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Fas- interacting serine/threonine-protein kinase) (FIST) (Nuclear body- associated kinase 3) (Nbak3) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

CD2L1_MOUSE
NC score	0.786395 (rank : 492)	θ value	5.44631e-05 (rank : 843)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1463	Shared Neighborhood Hits	972
SwissProt Accessions	P24788, Q3UI03, Q61399, Q7TST4, Q8BP53	Gene names	Cdc2l1
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1).

CD2L1_HUMAN
NC score	0.786264 (rank : 493)	θ value	5.44631e-05 (rank : 842)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1467	Shared Neighborhood Hits	976
SwissProt Accessions	P21127, O95265, Q12817, Q12818, Q12819, Q12820, Q12822, Q8N530, Q9NZS5, Q9UBJ0, Q9UBQ1, Q9UBR0, Q9UNY2, Q9UP57, Q9UP58, Q9UP59	Gene names	CDC2L1, PITSLREA, PK58
Domain Architecture
Description	PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (Cell division cycle 2-like protein kinase 1) (CLK-1) (CDK11) (p58 CLK-1).

MK06_HUMAN
NC score	0.785939 (rank : 494)	θ value	2.88788e-06 (rank : 743)
Query Neighborhood Hits	1580	Target Neighborhood Hits	815	Shared Neighborhood Hits	785
SwissProt Accessions	Q16659, Q68DH4, Q8IYN8	Gene names	MAPK6, ERK3, PRKM6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3) (MAP kinase isoform p97) (p97- MAPK).

MK06_MOUSE
NC score	0.785707 (rank : 495)	θ value	2.88788e-06 (rank : 744)
Query Neighborhood Hits	1580	Target Neighborhood Hits	818	Shared Neighborhood Hits	787
SwissProt Accessions	Q61532, Q497T9, Q6YKB0, Q7TT30, Q80XH5, Q922U4, Q9JLU6	Gene names	Mapk6, Erk3, Prkm4, Prkm6
Domain Architecture
Description	Mitogen-activated protein kinase 6 (EC 2.7.11.24) (Extracellular signal-regulated kinase 3) (ERK-3).

E2AK4_MOUSE
NC score	0.785138 (rank : 496)	θ value	8.11959e-09 (rank : 585)
Query Neighborhood Hits	1580	Target Neighborhood Hits	984	Shared Neighborhood Hits	845
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

HIPK3_HUMAN
NC score	0.784622 (rank : 497)	θ value	5.8054e-15 (rank : 356)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	782
SwissProt Accessions	Q9H422, O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2	Gene names	HIPK3, DYRK6, FIST3, PKY
Domain Architecture	No domain graphic available
Description	Homeodomain-interacting protein kinase 3 (EC 2.7.11.1) (Homolog of protein kinase YAK1) (Fas-interacting serine/threonine-protein kinase) (FIST) (Androgen receptor-interacting nuclear protein kinase) (ANPK).

DYRK4_HUMAN
NC score	0.784554 (rank : 498)	θ value	1.02475e-11 (rank : 454)
Query Neighborhood Hits	1580	Target Neighborhood Hits	750	Shared Neighborhood Hits	732
SwissProt Accessions	Q9NR20, Q8NEF2, Q92631	Gene names	DYRK4
Domain Architecture	No domain graphic available
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 4 (EC 2.7.12.1).

HIPK1_HUMAN
NC score	0.784411 (rank : 499)	θ value	2.43908e-13 (rank : 396)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	777
SwissProt Accessions	Q86Z02, O75125, Q8IYD7, Q8NDN5, Q8NEB6, Q8TBZ1	Gene names	HIPK1, KIAA0630
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1).

HIPK1_MOUSE
NC score	0.784239 (rank : 500)	θ value	2.43908e-13 (rank : 397)
Query Neighborhood Hits	1580	Target Neighborhood Hits	838	Shared Neighborhood Hits	775
SwissProt Accessions	O88904, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7	Gene names	Hipk1, Kiaa0630, Myak, Nbak2
Domain Architecture
Description	Homeodomain-interacting protein kinase 1 (EC 2.7.11.1) (Protein kinase Myak) (Nuclear body-associated kinase 2).

WEE1_MOUSE
NC score	0.783566 (rank : 501)	θ value	1.06045e-08 (rank : 593)
Query Neighborhood Hits	1580	Target Neighborhood Hits	794	Shared Neighborhood Hits	746
SwissProt Accessions	P47810, Q9EPL7	Gene names	Wee1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase).

CD2L6_MOUSE
NC score	0.783088 (rank : 502)	θ value	1.53129e-07 (rank : 647)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	804
SwissProt Accessions	Q8BWD8, Q80TM1	Gene names	Cdc2l6, Kiaa1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6).

CD2L6_HUMAN
NC score	0.782814 (rank : 503)	θ value	1.53129e-07 (rank : 646)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	799
SwissProt Accessions	Q9BWU1, Q5JQZ7, Q5JR00, Q8TC78, Q9UPX2	Gene names	CDC2L6, CDK11, KIAA1028
Domain Architecture	No domain graphic available
Description	Cell division cycle 2-like protein kinase 6 (EC 2.7.11.22) (CDC2- related protein kinase 6) (Death-preventing kinase) (Cyclin-dependent kinase 11).

HIPK2_HUMAN
NC score	0.782285 (rank : 504)	θ value	1.42992e-13 (rank : 387)
Query Neighborhood Hits	1580	Target Neighborhood Hits	845	Shared Neighborhood Hits	780
SwissProt Accessions	Q9H2X6, Q75MR7, Q8WWI4, Q9H2Y1	Gene names	HIPK2
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (hHIPk2).

DYR1A_MOUSE
NC score	0.782086 (rank : 505)	θ value	2.13673e-09 (rank : 553)
Query Neighborhood Hits	1580	Target Neighborhood Hits	762	Shared Neighborhood Hits	744
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

DYR1A_HUMAN
NC score	0.782083 (rank : 506)	θ value	2.13673e-09 (rank : 552)
Query Neighborhood Hits	1580	Target Neighborhood Hits	764	Shared Neighborhood Hits	745
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

HIPK2_MOUSE
NC score	0.781823 (rank : 507)	θ value	1.42992e-13 (rank : 388)
Query Neighborhood Hits	1580	Target Neighborhood Hits	871	Shared Neighborhood Hits	779
SwissProt Accessions	Q9QZR5, O88905, Q99P45, Q99P46, Q9D2E6, Q9D474, Q9EQL2, Q9QZR4	Gene names	Hipk2, Nbak1, Stank
Domain Architecture
Description	Homeodomain-interacting protein kinase 2 (EC 2.7.11.1) (Nuclear body- associated kinase 1) (Sialophorin tail-associated nuclear serine/threonine-protein kinase).

M3K13_HUMAN
NC score	0.781665 (rank : 508)	θ value	4.91457e-14 (rank : 380)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	818
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

AAK1_HUMAN
NC score	0.781100 (rank : 509)	θ value	3.64472e-09 (rank : 562)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1077	Shared Neighborhood Hits	806
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

WNK2_HUMAN
NC score	0.780720 (rank : 510)	θ value	5.62301e-10 (rank : 522)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1407	Shared Neighborhood Hits	814
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

AAK1_MOUSE
NC score	0.780000 (rank : 511)	θ value	6.21693e-09 (rank : 576)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1051	Shared Neighborhood Hits	794
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

CDK8_HUMAN
NC score	0.779637 (rank : 512)	θ value	4.0297e-08 (rank : 618)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	794
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

GAK_HUMAN
NC score	0.778609 (rank : 513)	θ value	1.09739e-05 (rank : 781)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1028	Shared Neighborhood Hits	807
SwissProt Accessions	O14976, Q9BVY6	Gene names	GAK
Domain Architecture
Description	Cyclin G-associated kinase (EC 2.7.11.1).

TITIN_HUMAN
NC score	0.776941 (rank : 514)	θ value	5.96599e-36 (rank : 37)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2923	Shared Neighborhood Hits	1212
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

GAK_MOUSE
NC score	0.776504 (rank : 515)	θ value	3.77169e-06 (rank : 749)
Query Neighborhood Hits	1580	Target Neighborhood Hits	964	Shared Neighborhood Hits	802
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

PRP4B_HUMAN
NC score	0.775981 (rank : 516)	θ value	6.00763e-12 (rank : 443)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1030	Shared Neighborhood Hits	823
SwissProt Accessions	Q13523, Q8TDP2, Q96QT7, Q9UEE6	Gene names	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (PRP4 kinase).

RIPK5_MOUSE
NC score	0.775876 (rank : 517)	θ value	5.81887e-07 (rank : 687)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	828
SwissProt Accessions	Q6XUX1, Q3ULK4, Q5EBN5, Q8C7D4, Q8C923, Q9CTP7	Gene names	Ripk5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK).

RIPK5_HUMAN
NC score	0.775782 (rank : 518)	θ value	5.81887e-07 (rank : 686)
Query Neighborhood Hits	1580	Target Neighborhood Hits	864	Shared Neighborhood Hits	822
SwissProt Accessions	Q6XUX3, O75060, Q5RKT0, Q6IN87, Q6P997, Q86Y03, Q9P1S5	Gene names	RIPK5, KIAA0472, RIP5
Domain Architecture	No domain graphic available
Description	Receptor-interacting serine/threonine-protein kinase 5 (EC 2.7.11.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase).

PRP4B_MOUSE
NC score	0.774936 (rank : 519)	θ value	6.00763e-12 (rank : 444)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1040	Shared Neighborhood Hits	831
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

CLK1_HUMAN
NC score	0.773338 (rank : 520)	θ value	1.47974e-10 (rank : 491)
Query Neighborhood Hits	1580	Target Neighborhood Hits	756	Shared Neighborhood Hits	736
SwissProt Accessions	P49759	Gene names	CLK1, CLK
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1).

UHMK1_HUMAN
NC score	0.773312 (rank : 521)	θ value	0.00035302 (rank : 919)
Query Neighborhood Hits	1580	Target Neighborhood Hits	808	Shared Neighborhood Hits	753
SwissProt Accessions	Q8TAS1, Q96C22	Gene names	UHMK1, KIS, KIST
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

WEE1_HUMAN
NC score	0.772772 (rank : 522)	θ value	2.61198e-07 (rank : 666)
Query Neighborhood Hits	1580	Target Neighborhood Hits	777	Shared Neighborhood Hits	732
SwissProt Accessions	P30291	Gene names	WEE1
Domain Architecture
Description	Wee1-like protein kinase (EC 2.7.10.2) (Wee1A kinase) (WEE1hu).

CLK1_MOUSE
NC score	0.772161 (rank : 523)	θ value	5.62301e-10 (rank : 518)
Query Neighborhood Hits	1580	Target Neighborhood Hits	760	Shared Neighborhood Hits	742
SwissProt Accessions	P22518	Gene names	Clk1, Clk, Sty
Domain Architecture
Description	Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1) (Protein kinase STY).

UHMK1_MOUSE
NC score	0.771867 (rank : 524)	θ value	0.000461057 (rank : 929)
Query Neighborhood Hits	1580	Target Neighborhood Hits	809	Shared Neighborhood Hits	753
SwissProt Accessions	P97343, Q61775, Q9CYT1	Gene names	Uhmk1, Kis, Kist
Domain Architecture
Description	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (U2AF homology motif kinase 1).

M3K12_HUMAN
NC score	0.771829 (rank : 525)	θ value	2.0648e-12 (rank : 425)
Query Neighborhood Hits	1580	Target Neighborhood Hits	940	Shared Neighborhood Hits	836
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_MOUSE
NC score	0.771618 (rank : 526)	θ value	2.0648e-12 (rank : 426)
Query Neighborhood Hits	1580	Target Neighborhood Hits	957	Shared Neighborhood Hits	839
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K7_MOUSE
NC score	0.771223 (rank : 527)	θ value	2.52405e-10 (rank : 502)
Query Neighborhood Hits	1580	Target Neighborhood Hits	892	Shared Neighborhood Hits	835
SwissProt Accessions	Q62073	Gene names	Map3k7, Tak1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

M3K7_HUMAN
NC score	0.770812 (rank : 528)	θ value	7.34386e-10 (rank : 527)
Query Neighborhood Hits	1580	Target Neighborhood Hits	892	Shared Neighborhood Hits	833
SwissProt Accessions	O43318, O43317, O43319, Q5TDN2, Q5TDN3	Gene names	MAP3K7, TAK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta- activated kinase 1).

TRIB1_HUMAN
NC score	0.770808 (rank : 529)	θ value	1.09739e-05 (rank : 792)
Query Neighborhood Hits	1580	Target Neighborhood Hits	598	Shared Neighborhood Hits	585
SwissProt Accessions	Q96RU8, O15180, Q9H2Y8	Gene names	TRIB1, C8FW, GIG2, TRB1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1) (SKIP1) (G-protein-coupled receptor-induced protein 2) (GIG-2).

TRIB1_MOUSE
NC score	0.769005 (rank : 530)	θ value	5.44631e-05 (rank : 850)
Query Neighborhood Hits	1580	Target Neighborhood Hits	593	Shared Neighborhood Hits	586
SwissProt Accessions	Q8K4K4, Q8BFS7, Q8BJR9, Q8BZX3, Q91W04	Gene names	Trib1, Trb1
Domain Architecture	No domain graphic available
Description	Tribbles homolog 1 (TRB-1).

IRAK4_MOUSE
NC score	0.768047 (rank : 531)	θ value	6.21693e-09 (rank : 577)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	782
SwissProt Accessions	Q8R4K2, Q80WW1	Gene names	Irak4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4).

RIPK1_HUMAN
NC score	0.766341 (rank : 532)	θ value	4.76016e-09 (rank : 573)
Query Neighborhood Hits	1580	Target Neighborhood Hits	891	Shared Neighborhood Hits	813
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

CLK4_HUMAN
NC score	0.766224 (rank : 533)	θ value	2.36244e-08 (rank : 605)
Query Neighborhood Hits	1580	Target Neighborhood Hits	759	Shared Neighborhood Hits	740
SwissProt Accessions	Q9HAZ1	Gene names	CLK4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

M3K9_HUMAN
NC score	0.765458 (rank : 534)	θ value	3.64472e-09 (rank : 564)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1123	Shared Neighborhood Hits	896
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3K11_HUMAN
NC score	0.765177 (rank : 535)	θ value	3.08544e-08 (rank : 616)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1136	Shared Neighborhood Hits	898
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

CLK4_MOUSE
NC score	0.764832 (rank : 536)	θ value	2.36244e-08 (rank : 606)
Query Neighborhood Hits	1580	Target Neighborhood Hits	759	Shared Neighborhood Hits	740
SwissProt Accessions	O35493, O35721, Q8CEU9, Q99LU6	Gene names	Clk4
Domain Architecture
Description	Dual specificity protein kinase CLK4 (EC 2.7.12.1) (CDC-like kinase 4).

TESK1_MOUSE
NC score	0.764510 (rank : 537)	θ value	5.81887e-07 (rank : 688)
Query Neighborhood Hits	1580	Target Neighborhood Hits	862	Shared Neighborhood Hits	792
SwissProt Accessions	O70146, O70147	Gene names	Tesk1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

M3K10_HUMAN
NC score	0.764006 (rank : 538)	θ value	4.59992e-12 (rank : 438)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1071	Shared Neighborhood Hits	896
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

CLK2_HUMAN
NC score	0.763692 (rank : 539)	θ value	8.97725e-08 (rank : 631)
Query Neighborhood Hits	1580	Target Neighborhood Hits	752	Shared Neighborhood Hits	733
SwissProt Accessions	P49760, Q96CQ0	Gene names	CLK2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

TESK2_HUMAN
NC score	0.763178 (rank : 540)	θ value	5.44631e-05 (rank : 849)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	797
SwissProt Accessions	Q96S53, Q8N520, Q9Y3Q6	Gene names	TESK2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TESK1_HUMAN
NC score	0.763061 (rank : 541)	θ value	3.77169e-06 (rank : 756)
Query Neighborhood Hits	1580	Target Neighborhood Hits	864	Shared Neighborhood Hits	794
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TESK2_MOUSE
NC score	0.762687 (rank : 542)	θ value	8.40245e-06 (rank : 777)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	794
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

IRAK4_HUMAN
NC score	0.760320 (rank : 543)	θ value	1.80886e-08 (rank : 601)
Query Neighborhood Hits	1580	Target Neighborhood Hits	816	Shared Neighborhood Hits	784
SwissProt Accessions	Q9NWZ3, Q8TDF7, Q9Y589	Gene names	IRAK4
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 4 (EC 2.7.11.1) (IRAK-4) (NY- REN-64 antigen).

RIPK1_MOUSE
NC score	0.757743 (rank : 544)	θ value	4.45536e-07 (rank : 676)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	810
SwissProt Accessions	Q60855, Q3U0J3, Q8CD90	Gene names	Ripk1, Rinp, Rip
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

M3KL4_HUMAN
NC score	0.756673 (rank : 545)	θ value	4.76016e-09 (rank : 571)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1087	Shared Neighborhood Hits	911
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

WEE1B_HUMAN
NC score	0.756533 (rank : 546)	θ value	1.87187e-05 (rank : 818)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	729
SwissProt Accessions	P0C1S8	Gene names	WEE1B, WEE2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase).

TRIB3_MOUSE
NC score	0.753866 (rank : 547)	θ value	1.09739e-05 (rank : 793)
Query Neighborhood Hits	1580	Target Neighborhood Hits	578	Shared Neighborhood Hits	569
SwissProt Accessions	Q8K4K2, Q3UMQ0, Q921E7	Gene names	Trib3, Nipk, Trb3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase).

RAF1_MOUSE
NC score	0.753034 (rank : 548)	θ value	6.21693e-09 (rank : 583)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	820
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_HUMAN
NC score	0.752465 (rank : 549)	θ value	6.21693e-09 (rank : 582)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	819
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

BRAF1_HUMAN
NC score	0.752364 (rank : 550)	θ value	1.38499e-08 (rank : 594)
Query Neighborhood Hits	1580	Target Neighborhood Hits	883	Shared Neighborhood Hits	817
SwissProt Accessions	P15056, Q13878, Q9Y6T3	Gene names	BRAF, BRAF1, RAFB1
Domain Architecture
Description	B-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1).

WEE1B_MOUSE
NC score	0.752299 (rank : 551)	θ value	0.00509761 (rank : 1011)
Query Neighborhood Hits	1580	Target Neighborhood Hits	765	Shared Neighborhood Hits	722
SwissProt Accessions	Q66JT0, Q4U4S4, Q7TPV9	Gene names	Wee1b, Wee2
Domain Architecture	No domain graphic available
Description	Wee1-like protein kinase 1B (EC 2.7.10.2) (Wee1B kinase) (mWee1B).

CLK2_MOUSE
NC score	0.751732 (rank : 552)	θ value	7.59969e-07 (rank : 692)
Query Neighborhood Hits	1580	Target Neighborhood Hits	743	Shared Neighborhood Hits	728
SwissProt Accessions	O35491	Gene names	Clk2
Domain Architecture
Description	Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2).

MLTK_MOUSE
NC score	0.749846 (rank : 553)	θ value	2.98157e-11 (rank : 472)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	807
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MOS_HUMAN
NC score	0.749569 (rank : 554)	θ value	7.59969e-07 (rank : 698)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	805
SwissProt Accessions	P00540	Gene names	MOS
Domain Architecture
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

MLTK_HUMAN
NC score	0.749233 (rank : 555)	θ value	2.28291e-11 (rank : 467)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	811
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

RIPK3_MOUSE
NC score	0.749117 (rank : 556)	θ value	1.43324e-05 (rank : 801)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	788
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

MOS_MOUSE
NC score	0.746623 (rank : 557)	θ value	3.77169e-06 (rank : 752)
Query Neighborhood Hits	1580	Target Neighborhood Hits	833	Shared Neighborhood Hits	803
SwissProt Accessions	P00536	Gene names	Mos
Domain Architecture	No domain graphic available
Description	Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (c- mos) (Oocyte maturation factor mos).

ARAF_HUMAN
NC score	0.746315 (rank : 558)	θ value	2.88788e-06 (rank : 739)
Query Neighborhood Hits	1580	Target Neighborhood Hits	924	Shared Neighborhood Hits	815
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

MYO3A_MOUSE
NC score	0.746195 (rank : 559)	θ value	3.52202e-12 (rank : 437)
Query Neighborhood Hits	1580	Target Neighborhood Hits	902	Shared Neighborhood Hits	835
SwissProt Accessions	Q8K3H5	Gene names	Myo3a
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

ARAF_MOUSE
NC score	0.745835 (rank : 560)	θ value	1.69304e-06 (rank : 722)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	812
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

RIPK3_HUMAN
NC score	0.742178 (rank : 561)	θ value	7.1131e-05 (rank : 860)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	789
SwissProt Accessions	Q9Y572	Gene names	RIPK3, RIP3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3).

MYO3A_HUMAN
NC score	0.741795 (rank : 562)	θ value	1.86753e-13 (rank : 392)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1033	Shared Neighborhood Hits	872
SwissProt Accessions	Q8NEV4, Q8WX17, Q9NYS8	Gene names	MYO3A
Domain Architecture
Description	Myosin IIIA (EC 2.7.11.1).

CLK3_HUMAN
NC score	0.740925 (rank : 563)	θ value	1.06045e-08 (rank : 589)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	728
SwissProt Accessions	P49761, Q9BRS3, Q9BUJ7	Gene names	CLK3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

LIMK2_HUMAN
NC score	0.740701 (rank : 564)	θ value	4.45536e-07 (rank : 674)
Query Neighborhood Hits	1580	Target Neighborhood Hits	986	Shared Neighborhood Hits	798
SwissProt Accessions	P53671, Q7KZ80, Q96E10, Q99464	Gene names	LIMK2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

CLK3_MOUSE
NC score	0.740290 (rank : 565)	θ value	1.06045e-08 (rank : 590)
Query Neighborhood Hits	1580	Target Neighborhood Hits	761	Shared Neighborhood Hits	728
SwissProt Accessions	O35492	Gene names	Clk3
Domain Architecture
Description	Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3).

LIMK2_MOUSE
NC score	0.738133 (rank : 566)	θ value	1.69304e-06 (rank : 725)
Query Neighborhood Hits	1580	Target Neighborhood Hits	998	Shared Neighborhood Hits	798
SwissProt Accessions	O54785, O54776, O55238, Q9QUL4	Gene names	Limk2
Domain Architecture
Description	LIM domain kinase 2 (EC 2.7.11.1) (LIMK-2).

MYO3B_HUMAN
NC score	0.735300 (rank : 567)	θ value	1.68911e-14 (rank : 371)
Query Neighborhood Hits	1580	Target Neighborhood Hits	923	Shared Neighborhood Hits	833
SwissProt Accessions	Q8WXR4, Q8IX64, Q8IX65, Q8IX66, Q8IX67, Q8IX68	Gene names	MYO3B
Domain Architecture
Description	Myosin IIIB (EC 2.7.11.1).

LIMK1_HUMAN
NC score	0.735227 (rank : 568)	θ value	1.09739e-05 (rank : 785)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1005	Shared Neighborhood Hits	803
SwissProt Accessions	P53667, O15283, Q15820, Q15821, Q75MU3, Q9Y5Q1	Gene names	LIMK1, LIMK
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1).

LIMK1_MOUSE
NC score	0.734738 (rank : 569)	θ value	6.43352e-06 (rank : 763)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1008	Shared Neighborhood Hits	803
SwissProt Accessions	P53668	Gene names	Limk1, Limk
Domain Architecture
Description	LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1).

PINK1_MOUSE
NC score	0.733670 (rank : 570)	θ value	7.59969e-07 (rank : 699)
Query Neighborhood Hits	1580	Target Neighborhood Hits	726	Shared Neighborhood Hits	703
SwissProt Accessions	Q99MQ3, Q7TMZ3, Q811I8, Q91XU5	Gene names	Pink1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

TRIB3_HUMAN
NC score	0.733363 (rank : 571)	θ value	0.00102713 (rank : 960)
Query Neighborhood Hits	1580	Target Neighborhood Hits	519	Shared Neighborhood Hits	514
SwissProt Accessions	Q96RU7, Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q9H5M8, Q9NUD2	Gene names	TRIB3, C20orf97, NIPK, SKIP3, TRB3
Domain Architecture
Description	Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (p65-interacting inhibitor of NF-kappaB) (SINK).

KSR2_HUMAN
NC score	0.729405 (rank : 572)	θ value	0.00175202 (rank : 973)
Query Neighborhood Hits	1580	Target Neighborhood Hits	920	Shared Neighborhood Hits	799
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

PINK1_HUMAN
NC score	0.729380 (rank : 573)	θ value	9.92553e-07 (rank : 714)
Query Neighborhood Hits	1580	Target Neighborhood Hits	741	Shared Neighborhood Hits	704
SwissProt Accessions	Q9BXM7, Q8N6T9, Q8NBU3, Q96DE4	Gene names	PINK1
Domain Architecture
Description	Serine/threonine-protein kinase PINK1, mitochondrial precursor (EC 2.7.11.1) (PTEN-induced putative kinase protein 1) (BRPK).

JAK3_MOUSE
NC score	0.718586 (rank : 574)	θ value	1.38499e-08 (rank : 598)
Query Neighborhood Hits	1580	Target Neighborhood Hits	821	Shared Neighborhood Hits	789
SwissProt Accessions	Q62137, Q61746, Q61747	Gene names	Jak3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3).

JAK2_HUMAN
NC score	0.715683 (rank : 575)	θ value	2.36244e-08 (rank : 608)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	804
SwissProt Accessions	O60674, O14636, O75297	Gene names	JAK2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

JAK2_MOUSE
NC score	0.714814 (rank : 576)	θ value	1.06045e-08 (rank : 591)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	800
SwissProt Accessions	Q62120, Q62124	Gene names	Jak2
Domain Architecture
Description	Tyrosine-protein kinase JAK2 (EC 2.7.10.2) (Janus kinase 2) (JAK-2).

AL2S2_HUMAN
NC score	0.713835 (rank : 577)	θ value	4.03905 (rank : 1416)
Query Neighborhood Hits	1580	Target Neighborhood Hits	727	Shared Neighborhood Hits	705
SwissProt Accessions	Q9C0K7, Q5BKY7, Q9P1L0	Gene names	ALS2CR2, ILPIP
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (ILP- interacting protein) (CALS-21).

JAK3_HUMAN
NC score	0.712286 (rank : 578)	θ value	2.52405e-10 (rank : 501)
Query Neighborhood Hits	1580	Target Neighborhood Hits	827	Shared Neighborhood Hits	796
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

LRRK1_HUMAN
NC score	0.710993 (rank : 579)	θ value	1.43324e-05 (rank : 796)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1237	Shared Neighborhood Hits	822
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

RPKL1_MOUSE
NC score	0.708730 (rank : 580)	θ value	0.00020696 (rank : 896)
Query Neighborhood Hits	1580	Target Neighborhood Hits	704	Shared Neighborhood Hits	655
SwissProt Accessions	Q8R2S1, Q8R1D4	Gene names	Rps6kl1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

TYK2_HUMAN
NC score	0.708721 (rank : 581)	θ value	2.61198e-07 (rank : 665)
Query Neighborhood Hits	1580	Target Neighborhood Hits	841	Shared Neighborhood Hits	801
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

RPKL1_HUMAN
NC score	0.708623 (rank : 582)	θ value	0.0113563 (rank : 1039)
Query Neighborhood Hits	1580	Target Neighborhood Hits	708	Shared Neighborhood Hits	650
SwissProt Accessions	Q9Y6S9, Q69YT9, Q6ZMQ6, Q96NR9, Q9BSU9	Gene names	RPS6KL1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase-like 1 (EC 2.7.11.1).

LRRK1_MOUSE
NC score	0.708118 (rank : 583)	θ value	1.29631e-06 (rank : 719)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1267	Shared Neighborhood Hits	829
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

FES_MOUSE
NC score	0.705116 (rank : 584)	θ value	1.38499e-08 (rank : 596)
Query Neighborhood Hits	1580	Target Neighborhood Hits	980	Shared Neighborhood Hits	860
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

TYK2_MOUSE
NC score	0.703886 (rank : 585)	θ value	1.69304e-06 (rank : 731)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	799
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

PTK6_HUMAN
NC score	0.703628 (rank : 586)	θ value	7.59969e-07 (rank : 700)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1020	Shared Neighborhood Hits	844
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

FES_HUMAN
NC score	0.703089 (rank : 587)	θ value	1.38499e-08 (rank : 595)
Query Neighborhood Hits	1580	Target Neighborhood Hits	978	Shared Neighborhood Hits	836
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

PTK6_MOUSE
NC score	0.702355 (rank : 588)	θ value	5.26297e-08 (rank : 624)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1026	Shared Neighborhood Hits	847
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

AL2S2_MOUSE
NC score	0.701545 (rank : 589)	θ value	1.06291 (rank : 1270)
Query Neighborhood Hits	1580	Target Neighborhood Hits	709	Shared Neighborhood Hits	687
SwissProt Accessions	Q8K4T3, Q6P922, Q8BU86, Q8BXK0, Q8K4T2	Gene names	Als2cr2, Papk
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ALS2CR2 (EC 2.7.11.1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog) (ILP-interacting protein homolog) (Polyploidy-associated protein kinase).

LRRK2_HUMAN
NC score	0.700111 (rank : 590)	θ value	1.42992e-13 (rank : 389)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1382	Shared Neighborhood Hits	840
SwissProt Accessions	Q5S007, Q6ZS50, Q8NCX9	Gene names	LRRK2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (Dardarin).

FER_HUMAN
NC score	0.699912 (rank : 591)	θ value	7.59969e-07 (rank : 696)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1278	Shared Neighborhood Hits	981
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

KSR1_MOUSE
NC score	0.698336 (rank : 592)	θ value	0.21417 (rank : 1173)
Query Neighborhood Hits	1580	Target Neighborhood Hits	870	Shared Neighborhood Hits	789
SwissProt Accessions	Q61097, Q61648, Q78DX8	Gene names	Ksr1, Ksr
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras) (mKSR1) (Hb protein).

JAK1_HUMAN
NC score	0.697579 (rank : 593)	θ value	1.29631e-06 (rank : 717)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	805
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

TEC_MOUSE
NC score	0.695069 (rank : 594)	θ value	3.29651e-10 (rank : 511)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1006	Shared Neighborhood Hits	836
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RIPK2_HUMAN
NC score	0.692032 (rank : 595)	θ value	0.00134147 (rank : 968)
Query Neighborhood Hits	1580	Target Neighborhood Hits	774	Shared Neighborhood Hits	738
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

CSK_MOUSE
NC score	0.691797 (rank : 596)	θ value	1.63604e-09 (rank : 544)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	839
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

KSYK_MOUSE
NC score	0.690626 (rank : 597)	θ value	1.2105e-12 (rank : 414)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	807
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_HUMAN
NC score	0.690508 (rank : 598)	θ value	2.69671e-12 (rank : 429)
Query Neighborhood Hits	1580	Target Neighborhood Hits	901	Shared Neighborhood Hits	801
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

TEC_HUMAN
NC score	0.690345 (rank : 599)	θ value	4.30538e-10 (rank : 516)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1006	Shared Neighborhood Hits	837
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

RIPK2_MOUSE
NC score	0.689436 (rank : 600)	θ value	0.0193708 (rank : 1063)
Query Neighborhood Hits	1580	Target Neighborhood Hits	776	Shared Neighborhood Hits	739
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

JAK1_MOUSE
NC score	0.689364 (rank : 601)	θ value	1.87187e-05 (rank : 814)
Query Neighborhood Hits	1580	Target Neighborhood Hits	854	Shared Neighborhood Hits	802
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

KS6C1_MOUSE
NC score	0.688357 (rank : 602)	θ value	0.813845 (rank : 1259)
Query Neighborhood Hits	1580	Target Neighborhood Hits	700	Shared Neighborhood Hits	634
SwissProt Accessions	Q8BLK9, Q3UDY3, Q6PDY4, Q8BMQ5, Q8BX49	Gene names	Rps6kc1
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase).

KSR1_HUMAN
NC score	0.688227 (rank : 603)	θ value	0.21417 (rank : 1172)
Query Neighborhood Hits	1580	Target Neighborhood Hits	867	Shared Neighborhood Hits	774
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

ZAP70_HUMAN
NC score	0.687857 (rank : 604)	θ value	3.08544e-08 (rank : 617)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	800
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

TXK_HUMAN
NC score	0.686242 (rank : 605)	θ value	1.47974e-10 (rank : 493)
Query Neighborhood Hits	1580	Target Neighborhood Hits	971	Shared Neighborhood Hits	828
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ZAP70_MOUSE
NC score	0.685758 (rank : 606)	θ value	6.87365e-08 (rank : 630)
Query Neighborhood Hits	1580	Target Neighborhood Hits	905	Shared Neighborhood Hits	808
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

KS6C1_HUMAN
NC score	0.685381 (rank : 607)	θ value	0.21417 (rank : 1171)
Query Neighborhood Hits	1580	Target Neighborhood Hits	682	Shared Neighborhood Hits	636
SwissProt Accessions	Q96S38, Q8TDD3, Q9NSF4, Q9UL66	Gene names	RPS6KC1, RPK118
Domain Architecture	No domain graphic available
Description	Ribosomal protein S6 kinase delta-1 (EC 2.7.11.1) (52 kDa ribosomal protein S6 kinase) (Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein) (SPHK1-binding protein).

CDC7_HUMAN
NC score	0.685352 (rank : 608)	θ value	0.0330416 (rank : 1077)
Query Neighborhood Hits	1580	Target Neighborhood Hits	652	Shared Neighborhood Hits	625
SwissProt Accessions	O00311, O00558	Gene names	CDC7, CDC7L1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (HsCdc7) (huCdc7).

ABL1_MOUSE
NC score	0.685051 (rank : 609)	θ value	7.09661e-13 (rank : 404)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1178	Shared Neighborhood Hits	873
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BTK_HUMAN
NC score	0.685017 (rank : 610)	θ value	2.52405e-10 (rank : 498)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1026	Shared Neighborhood Hits	838
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

CSK_HUMAN
NC score	0.684107 (rank : 611)	θ value	2.13673e-09 (rank : 551)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	838
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ABL1_HUMAN
NC score	0.683891 (rank : 612)	θ value	9.26847e-13 (rank : 409)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1220	Shared Neighborhood Hits	873
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

BTK_MOUSE
NC score	0.683533 (rank : 613)	θ value	2.52405e-10 (rank : 499)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1017	Shared Neighborhood Hits	835
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

ITK_HUMAN
NC score	0.683024 (rank : 614)	θ value	7.34386e-10 (rank : 525)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1016	Shared Neighborhood Hits	846
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

LRRK2_MOUSE
NC score	0.682652 (rank : 615)	θ value	2.0648e-12 (rank : 424)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1359	Shared Neighborhood Hits	829
SwissProt Accessions	Q5S006, Q8BWG7, Q8BZJ6, Q8CI84, Q8K062	Gene names	Lrrk2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1).

CDC7_MOUSE
NC score	0.682291 (rank : 616)	θ value	0.0330416 (rank : 1078)
Query Neighborhood Hits	1580	Target Neighborhood Hits	641	Shared Neighborhood Hits	621
SwissProt Accessions	Q9Z0H0, Q9Z2Y7	Gene names	Cdc7, Cdc7l1
Domain Architecture
Description	Cell division cycle 7-related protein kinase (EC 2.7.11.1) (CDC7- related kinase) (muCdc7).

ITK_MOUSE
NC score	0.681847 (rank : 617)	θ value	1.25267e-09 (rank : 539)
Query Neighborhood Hits	1580	Target Neighborhood Hits	985	Shared Neighborhood Hits	839
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

LYN_MOUSE
NC score	0.681337 (rank : 618)	θ value	7.34386e-10 (rank : 526)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1023	Shared Neighborhood Hits	851
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ABL2_HUMAN
NC score	0.681336 (rank : 619)	θ value	1.2105e-12 (rank : 412)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1045	Shared Neighborhood Hits	841
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

LYN_HUMAN
NC score	0.681023 (rank : 620)	θ value	1.25267e-09 (rank : 540)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1022	Shared Neighborhood Hits	853
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

BMX_HUMAN
NC score	0.680022 (rank : 621)	θ value	8.67504e-11 (rank : 482)
Query Neighborhood Hits	1580	Target Neighborhood Hits	942	Shared Neighborhood Hits	794
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

FRK_HUMAN
NC score	0.679857 (rank : 622)	θ value	6.87365e-08 (rank : 628)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1058	Shared Neighborhood Hits	850
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

BMX_MOUSE
NC score	0.679590 (rank : 623)	θ value	5.08577e-11 (rank : 475)
Query Neighborhood Hits	1580	Target Neighborhood Hits	912	Shared Neighborhood Hits	786
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

FAK1_HUMAN
NC score	0.679168 (rank : 624)	θ value	5.81887e-07 (rank : 680)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	795
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
NC score	0.678750 (rank : 625)	θ value	5.81887e-07 (rank : 681)
Query Neighborhood Hits	1580	Target Neighborhood Hits	850	Shared Neighborhood Hits	793
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

MATK_MOUSE
NC score	0.677371 (rank : 626)	θ value	2.79066e-09 (rank : 560)
Query Neighborhood Hits	1580	Target Neighborhood Hits	952	Shared Neighborhood Hits	819
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

SRMS_MOUSE
NC score	0.676918 (rank : 627)	θ value	4.30538e-10 (rank : 515)
Query Neighborhood Hits	1580	Target Neighborhood Hits	964	Shared Neighborhood Hits	827
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

FGFR1_MOUSE
NC score	0.676633 (rank : 628)	θ value	0.00020696 (rank : 891)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1068	Shared Neighborhood Hits	974
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.676591 (rank : 629)	θ value	0.00020696 (rank : 890)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1069	Shared Neighborhood Hits	975
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR2_HUMAN
NC score	0.676206 (rank : 630)	θ value	1.87187e-05 (rank : 811)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1062	Shared Neighborhood Hits	968
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
NC score	0.675457 (rank : 631)	θ value	1.87187e-05 (rank : 812)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1062	Shared Neighborhood Hits	964
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

TXK_MOUSE
NC score	0.675272 (rank : 632)	θ value	1.33837e-11 (rank : 460)
Query Neighborhood Hits	1580	Target Neighborhood Hits	980	Shared Neighborhood Hits	822
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

NTRK2_HUMAN
NC score	0.673854 (rank : 633)	θ value	0.000786445 (rank : 946)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1081	Shared Neighborhood Hits	945
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

MATK_HUMAN
NC score	0.673436 (rank : 634)	θ value	1.80886e-08 (rank : 602)
Query Neighborhood Hits	1580	Target Neighborhood Hits	954	Shared Neighborhood Hits	820
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

NTRK2_MOUSE
NC score	0.673357 (rank : 635)	θ value	0.000786445 (rank : 947)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1088	Shared Neighborhood Hits	945
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

IRAK1_HUMAN
NC score	0.672948 (rank : 636)	θ value	0.00102713 (rank : 955)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	743
SwissProt Accessions	P51617, Q7Z5V4, Q96RL2	Gene names	IRAK1, IRAK
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1).

SRMS_HUMAN
NC score	0.671111 (rank : 637)	θ value	3.64472e-09 (rank : 567)
Query Neighborhood Hits	1580	Target Neighborhood Hits	946	Shared Neighborhood Hits	821
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

FAK2_MOUSE
NC score	0.670412 (rank : 638)	θ value	2.61198e-07 (rank : 661)
Query Neighborhood Hits	1580	Target Neighborhood Hits	851	Shared Neighborhood Hits	786
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

IRAK1_MOUSE
NC score	0.669271 (rank : 639)	θ value	0.00102713 (rank : 956)
Query Neighborhood Hits	1580	Target Neighborhood Hits	784	Shared Neighborhood Hits	726
SwissProt Accessions	Q62406, Q6Y3Z5, Q6Y3Z6	Gene names	Irak1, Il1rak
Domain Architecture
Description	Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK).

BLK_HUMAN
NC score	0.668920 (rank : 640)	θ value	5.62301e-10 (rank : 517)
Query Neighborhood Hits	1580	Target Neighborhood Hits	994	Shared Neighborhood Hits	846
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FYN_HUMAN
NC score	0.668726 (rank : 641)	θ value	2.36244e-08 (rank : 607)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1078	Shared Neighborhood Hits	852
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

LCK_MOUSE
NC score	0.668029 (rank : 642)	θ value	3.29651e-10 (rank : 508)
Query Neighborhood Hits	1580	Target Neighborhood Hits	981	Shared Neighborhood Hits	833
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

FGFR3_HUMAN
NC score	0.668024 (rank : 643)	θ value	1.09739e-05 (rank : 780)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1042	Shared Neighborhood Hits	961
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

BLK_MOUSE
NC score	0.667675 (rank : 644)	θ value	1.133e-10 (rank : 485)
Query Neighborhood Hits	1580	Target Neighborhood Hits	992	Shared Neighborhood Hits	844
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

HCK_HUMAN
NC score	0.666442 (rank : 645)	θ value	1.99992e-07 (rank : 657)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1035	Shared Neighborhood Hits	850
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

FGFR3_MOUSE
NC score	0.665733 (rank : 646)	θ value	2.44474e-05 (rank : 820)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1059	Shared Neighborhood Hits	965
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FAK2_HUMAN
NC score	0.665569 (rank : 647)	θ value	3.41135e-07 (rank : 667)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	787
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FYN_MOUSE
NC score	0.664889 (rank : 648)	θ value	1.25267e-09 (rank : 538)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1073	Shared Neighborhood Hits	854
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

LCK_HUMAN
NC score	0.662735 (rank : 649)	θ value	9.59137e-10 (rank : 532)
Query Neighborhood Hits	1580	Target Neighborhood Hits	987	Shared Neighborhood Hits	835
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

HCK_MOUSE
NC score	0.662099 (rank : 650)	θ value	9.92553e-07 (rank : 708)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1029	Shared Neighborhood Hits	853
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

TNK1_MOUSE
NC score	0.661756 (rank : 651)	θ value	0.000158464 (rank : 883)
Query Neighborhood Hits	1580	Target Neighborhood Hits	806	Shared Neighborhood Hits	763
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

SRC_HUMAN
NC score	0.661139 (rank : 652)	θ value	6.21693e-09 (rank : 584)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1058	Shared Neighborhood Hits	840
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
NC score	0.660762 (rank : 653)	θ value	4.76016e-09 (rank : 574)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1033	Shared Neighborhood Hits	836
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

FGFR4_HUMAN
NC score	0.658956 (rank : 654)	θ value	0.000158464 (rank : 877)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1037	Shared Neighborhood Hits	965
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

YES_HUMAN
NC score	0.658423 (rank : 655)	θ value	2.52405e-10 (rank : 504)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1059	Shared Neighborhood Hits	840
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
NC score	0.657984 (rank : 656)	θ value	3.29651e-10 (rank : 512)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1052	Shared Neighborhood Hits	835
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ROR1_MOUSE
NC score	0.656096 (rank : 657)	θ value	3.19293e-05 (rank : 834)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1025	Shared Neighborhood Hits	940
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

TTBK1_HUMAN
NC score	0.655959 (rank : 658)	θ value	θ > 10 (rank : 2175)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1058	Shared Neighborhood Hits	742
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

PTK7_HUMAN
NC score	0.654864 (rank : 659)	θ value	2.88788e-06 (rank : 746)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1103	Shared Neighborhood Hits	956
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

ROR1_HUMAN
NC score	0.654857 (rank : 660)	θ value	3.19293e-05 (rank : 833)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1018	Shared Neighborhood Hits	937
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

TIE2_HUMAN
NC score	0.653796 (rank : 661)	θ value	1.29631e-06 (rank : 721)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1192	Shared Neighborhood Hits	864
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
NC score	0.653279 (rank : 662)	θ value	1.69304e-06 (rank : 728)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1204	Shared Neighborhood Hits	865
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

FGR_HUMAN
NC score	0.653162 (rank : 663)	θ value	8.97725e-08 (rank : 634)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1067	Shared Neighborhood Hits	843
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TNK1_HUMAN
NC score	0.651369 (rank : 664)	θ value	0.00134147 (rank : 969)
Query Neighborhood Hits	1580	Target Neighborhood Hits	815	Shared Neighborhood Hits	761
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

EPHA5_MOUSE
NC score	0.650692 (rank : 665)	θ value	0.000270298 (rank : 901)
Query Neighborhood Hits	1580	Target Neighborhood Hits	950	Shared Neighborhood Hits	837
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

FGR_MOUSE
NC score	0.649717 (rank : 666)	θ value	1.29631e-06 (rank : 716)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1069	Shared Neighborhood Hits	845
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

RET_HUMAN
NC score	0.647567 (rank : 667)	θ value	0.000121331 (rank : 874)
Query Neighborhood Hits	1580	Target Neighborhood Hits	873	Shared Neighborhood Hits	791
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

TTBK2_HUMAN
NC score	0.647404 (rank : 668)	θ value	θ > 10 (rank : 2176)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	709
SwissProt Accessions	Q6IQ55, O94932, Q6ZN52, Q8IVV1	Gene names	TTBK2, KIAA0847
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2 (EC 2.7.11.1).

ACK1_HUMAN
NC score	0.647294 (rank : 669)	θ value	1.133e-10 (rank : 484)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1140	Shared Neighborhood Hits	837
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ACK1_MOUSE
NC score	0.645873 (rank : 670)	θ value	1.25267e-09 (rank : 535)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1080	Shared Neighborhood Hits	832
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

RET_MOUSE
NC score	0.645775 (rank : 671)	θ value	0.000158464 (rank : 882)
Query Neighborhood Hits	1580	Target Neighborhood Hits	884	Shared Neighborhood Hits	790
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

EPHB1_HUMAN
NC score	0.645509 (rank : 672)	θ value	5.81887e-07 (rank : 678)
Query Neighborhood Hits	1580	Target Neighborhood Hits	988	Shared Neighborhood Hits	839
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

KC1A_HUMAN
NC score	0.645439 (rank : 673)	θ value	0.279714 (rank : 1191)
Query Neighborhood Hits	1580	Target Neighborhood Hits	728	Shared Neighborhood Hits	715
SwissProt Accessions	P48729, Q96HD2	Gene names	CSNK1A1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

KC1A_MOUSE
NC score	0.645439 (rank : 674)	θ value	0.279714 (rank : 1192)
Query Neighborhood Hits	1580	Target Neighborhood Hits	728	Shared Neighborhood Hits	715
SwissProt Accessions	Q8BK63, Q3UIL0, Q64506, Q80XI2, Q99LY3	Gene names	Csnk1a1
Domain Architecture
Description	Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha) (CK1).

NTRK3_HUMAN
NC score	0.644811 (rank : 675)	θ value	7.1131e-05 (rank : 859)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1115	Shared Neighborhood Hits	929
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

TTBK2_MOUSE
NC score	0.644274 (rank : 676)	θ value	θ > 10 (rank : 2177)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	702
SwissProt Accessions	Q3UVR3, Q3TSR6, Q3UFW0, Q571D1, Q8BKA4, Q924U8	Gene names	Ttbk2, Kiaa0847, Ttbk1
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 2.

ROR2_HUMAN
NC score	0.643200 (rank : 677)	θ value	3.64472e-09 (rank : 566)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1014	Shared Neighborhood Hits	925
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

KC1AL_HUMAN
NC score	0.642826 (rank : 678)	θ value	0.279714 (rank : 1190)
Query Neighborhood Hits	1580	Target Neighborhood Hits	734	Shared Neighborhood Hits	714
SwissProt Accessions	Q8N752	Gene names	CSNK1A1L
Domain Architecture
Description	Casein kinase I isoform alpha-like (EC 2.7.11.1) (CKI-alpha-like) (CK1).

EPHA7_MOUSE
NC score	0.641571 (rank : 679)	θ value	7.59969e-07 (rank : 695)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1025	Shared Neighborhood Hits	848
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA7_HUMAN
NC score	0.641334 (rank : 680)	θ value	9.92553e-07 (rank : 706)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1053	Shared Neighborhood Hits	851
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA3_HUMAN
NC score	0.640737 (rank : 681)	θ value	0.00020696 (rank : 889)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1005	Shared Neighborhood Hits	863
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

STYK1_HUMAN
NC score	0.640643 (rank : 682)	θ value	1.43324e-05 (rank : 802)
Query Neighborhood Hits	1580	Target Neighborhood Hits	786	Shared Neighborhood Hits	754
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

TIE1_MOUSE
NC score	0.639924 (rank : 683)	θ value	2.61198e-07 (rank : 664)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1266	Shared Neighborhood Hits	894
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

ERBB4_HUMAN
NC score	0.639557 (rank : 684)	θ value	8.40245e-06 (rank : 771)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	784
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

EPHB4_MOUSE
NC score	0.639376 (rank : 685)	θ value	8.97725e-08 (rank : 633)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1013	Shared Neighborhood Hits	838
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EGFR_MOUSE
NC score	0.638497 (rank : 686)	θ value	0.000121331 (rank : 871)
Query Neighborhood Hits	1580	Target Neighborhood Hits	927	Shared Neighborhood Hits	792
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EGFR_HUMAN
NC score	0.637740 (rank : 687)	θ value	0.000270298 (rank : 900)
Query Neighborhood Hits	1580	Target Neighborhood Hits	939	Shared Neighborhood Hits	789
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

FGFR4_MOUSE
NC score	0.637719 (rank : 688)	θ value	0.00134147 (rank : 963)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1026	Shared Neighborhood Hits	952
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

TNI3K_MOUSE
NC score	0.636397 (rank : 689)	θ value	θ > 10 (rank : 2158)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1079	Shared Neighborhood Hits	776
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

EPHA5_HUMAN
NC score	0.635855 (rank : 690)	θ value	0.000786445 (rank : 942)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	850
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHB4_HUMAN
NC score	0.635650 (rank : 691)	θ value	1.53129e-07 (rank : 650)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1056	Shared Neighborhood Hits	842
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

TIE1_HUMAN
NC score	0.635447 (rank : 692)	θ value	7.59969e-07 (rank : 703)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1241	Shared Neighborhood Hits	881
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

MUSK_HUMAN
NC score	0.634655 (rank : 693)	θ value	0.00102713 (rank : 958)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1074	Shared Neighborhood Hits	954
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

KC1D_HUMAN
NC score	0.634249 (rank : 694)	θ value	1.38821 (rank : 1305)
Query Neighborhood Hits	1580	Target Neighborhood Hits	737	Shared Neighborhood Hits	711
SwissProt Accessions	P48730, Q96KZ6, Q9BTN5	Gene names	CSNK1D
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

KC1D_MOUSE
NC score	0.634245 (rank : 695)	θ value	1.38821 (rank : 1306)
Query Neighborhood Hits	1580	Target Neighborhood Hits	737	Shared Neighborhood Hits	711
SwissProt Accessions	Q9DC28, Q3TZK2, Q99KK4	Gene names	Csnk1d
Domain Architecture
Description	Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta) (CKId).

EPHA3_MOUSE
NC score	0.633377 (rank : 696)	θ value	0.00134147 (rank : 962)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1009	Shared Neighborhood Hits	866
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

TYRO3_HUMAN
NC score	0.633144 (rank : 697)	θ value	θ > 10 (rank : 2183)
Query Neighborhood Hits	1580	Target Neighborhood Hits	995	Shared Neighborhood Hits	897
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

EPHA2_HUMAN
NC score	0.632641 (rank : 698)	θ value	0.00020696 (rank : 888)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1021	Shared Neighborhood Hits	846
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

TYRO3_MOUSE
NC score	0.632308 (rank : 699)	θ value	6.88961 (rank : 1519)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1007	Shared Neighborhood Hits	899
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

MUSK_MOUSE
NC score	0.632034 (rank : 700)	θ value	0.00020696 (rank : 894)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1057	Shared Neighborhood Hits	950
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

VGFR1_MOUSE
NC score	0.631617 (rank : 701)	θ value	2.44474e-05 (rank : 829)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1118	Shared Neighborhood Hits	980
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

EPHB2_MOUSE
NC score	0.631157 (rank : 702)	θ value	2.21117e-06 (rank : 734)
Query Neighborhood Hits	1580	Target Neighborhood Hits	982	Shared Neighborhood Hits	833
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB2_HUMAN
NC score	0.630969 (rank : 703)	θ value	2.21117e-06 (rank : 733)
Query Neighborhood Hits	1580	Target Neighborhood Hits	983	Shared Neighborhood Hits	833
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA2_MOUSE
NC score	0.630926 (rank : 704)	θ value	0.000786445 (rank : 941)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1020	Shared Neighborhood Hits	840
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

KC1E_HUMAN
NC score	0.630716 (rank : 705)	θ value	1.38821 (rank : 1307)
Query Neighborhood Hits	1580	Target Neighborhood Hits	732	Shared Neighborhood Hits	711
SwissProt Accessions	P49674	Gene names	CSNK1E
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

KC1E_MOUSE
NC score	0.630668 (rank : 706)	θ value	1.38821 (rank : 1308)
Query Neighborhood Hits	1580	Target Neighborhood Hits	728	Shared Neighborhood Hits	710
SwissProt Accessions	Q9JMK2, Q8R389	Gene names	Csnk1e
Domain Architecture
Description	Casein kinase I isoform epsilon (EC 2.7.11.1) (CKI-epsilon) (CKIe).

RON_HUMAN
NC score	0.630657 (rank : 707)	θ value	2.44474e-05 (rank : 828)
Query Neighborhood Hits	1580	Target Neighborhood Hits	842	Shared Neighborhood Hits	781
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

EPHA4_MOUSE
NC score	0.629964 (rank : 708)	θ value	4.1701e-05 (rank : 837)
Query Neighborhood Hits	1580	Target Neighborhood Hits	982	Shared Neighborhood Hits	845
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA4_HUMAN
NC score	0.629628 (rank : 709)	θ value	4.1701e-05 (rank : 836)
Query Neighborhood Hits	1580	Target Neighborhood Hits	975	Shared Neighborhood Hits	842
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

MET_MOUSE
NC score	0.629398 (rank : 710)	θ value	3.41135e-07 (rank : 669)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	774
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

TNI3K_HUMAN
NC score	0.629286 (rank : 711)	θ value	θ > 10 (rank : 2157)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1084	Shared Neighborhood Hits	781
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ERBB2_MOUSE
NC score	0.628848 (rank : 712)	θ value	1.87187e-05 (rank : 810)
Query Neighborhood Hits	1580	Target Neighborhood Hits	918	Shared Neighborhood Hits	791
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

EPHA8_HUMAN
NC score	0.628152 (rank : 713)	θ value	2.44474e-05 (rank : 819)
Query Neighborhood Hits	1580	Target Neighborhood Hits	956	Shared Neighborhood Hits	843
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

ROS_HUMAN
NC score	0.626652 (rank : 714)	θ value	0.00298849 (rank : 993)
Query Neighborhood Hits	1580	Target Neighborhood Hits	907	Shared Neighborhood Hits	805
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

MET_HUMAN
NC score	0.626578 (rank : 715)	θ value	9.92553e-07 (rank : 712)
Query Neighborhood Hits	1580	Target Neighborhood Hits	831	Shared Neighborhood Hits	773
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

AVR2A_MOUSE
NC score	0.626557 (rank : 716)	θ value	0.000461057 (rank : 921)
Query Neighborhood Hits	1580	Target Neighborhood Hits	767	Shared Neighborhood Hits	744
SwissProt Accessions	P27038	Gene names	Acvr2a, Acvr2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA).

AVR2A_HUMAN
NC score	0.626543 (rank : 717)	θ value	0.000461057 (rank : 920)
Query Neighborhood Hits	1580	Target Neighborhood Hits	767	Shared Neighborhood Hits	744
SwissProt Accessions	P27037, Q53TH4, Q6NWV2, Q92474	Gene names	ACVR2A, ACVR2
Domain Architecture
Description	Activin receptor type 2A precursor (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA).

IRAK2_HUMAN
NC score	0.626381 (rank : 718)	θ value	0.125558 (rank : 1146)
Query Neighborhood Hits	1580	Target Neighborhood Hits	714	Shared Neighborhood Hits	662
SwissProt Accessions	O43187	Gene names	IRAK2
Domain Architecture
Description	Interleukin-1 receptor-associated kinase-like 2 (IRAK-2).

ERBB2_HUMAN
NC score	0.626011 (rank : 719)	θ value	8.40245e-06 (rank : 770)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1073	Shared Neighborhood Hits	801
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

NTRK1_HUMAN
NC score	0.625926 (rank : 720)	θ value	0.000270298 (rank : 906)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1023	Shared Neighborhood Hits	868
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

SCYL2_HUMAN
NC score	0.625881 (rank : 721)	θ value	1.09739e-05 (rank : 790)
Query Neighborhood Hits	1580	Target Neighborhood Hits	632	Shared Neighborhood Hits	579
SwissProt Accessions	Q6P3W7, Q96EF4, Q96ST4, Q9H7V5, Q9NVH3, Q9P2I7	Gene names	SCYL2, CVAK104, KIAA1360
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

VGFR1_HUMAN
NC score	0.625780 (rank : 722)	θ value	2.21117e-06 (rank : 738)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1109	Shared Neighborhood Hits	973
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

EPHA1_HUMAN
NC score	0.625768 (rank : 723)	θ value	4.45536e-07 (rank : 673)
Query Neighborhood Hits	1580	Target Neighborhood Hits	997	Shared Neighborhood Hits	821
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

KC1G1_MOUSE
NC score	0.624885 (rank : 724)	θ value	0.813845 (rank : 1258)
Query Neighborhood Hits	1580	Target Neighborhood Hits	713	Shared Neighborhood Hits	692
SwissProt Accessions	Q8BTH8	Gene names	Csnk1g1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

EPHA8_MOUSE
NC score	0.623827 (rank : 725)	θ value	1.87187e-05 (rank : 808)
Query Neighborhood Hits	1580	Target Neighborhood Hits	969	Shared Neighborhood Hits	843
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

KC1G1_HUMAN
NC score	0.623264 (rank : 726)	θ value	0.813845 (rank : 1257)
Query Neighborhood Hits	1580	Target Neighborhood Hits	708	Shared Neighborhood Hits	690
SwissProt Accessions	Q9HCP0, Q96AE9, Q9HCP1	Gene names	CSNK1G1
Domain Architecture
Description	Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma 1).

STYK1_MOUSE
NC score	0.623030 (rank : 727)	θ value	0.000121331 (rank : 875)
Query Neighborhood Hits	1580	Target Neighborhood Hits	779	Shared Neighborhood Hits	749
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

VGFR2_MOUSE
NC score	0.622757 (rank : 728)	θ value	7.1131e-05 (rank : 861)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1089	Shared Neighborhood Hits	960
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

DDR2_MOUSE
NC score	0.622582 (rank : 729)	θ value	1.87187e-05 (rank : 807)
Query Neighborhood Hits	1580	Target Neighborhood Hits	813	Shared Neighborhood Hits	759
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

EPHB3_HUMAN
NC score	0.621830 (rank : 730)	θ value	5.81887e-07 (rank : 679)
Query Neighborhood Hits	1580	Target Neighborhood Hits	996	Shared Neighborhood Hits	847
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

KC1G3_HUMAN
NC score	0.620587 (rank : 731)	θ value	1.06291 (rank : 1282)
Query Neighborhood Hits	1580	Target Neighborhood Hits	711	Shared Neighborhood Hits	696
SwissProt Accessions	Q9Y6M4, Q86WZ7, Q9Y6M3	Gene names	CSNK1G3
Domain Architecture
Description	Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma 3).

EPHB3_MOUSE
NC score	0.620408 (rank : 732)	θ value	1.29631e-06 (rank : 715)
Query Neighborhood Hits	1580	Target Neighborhood Hits	996	Shared Neighborhood Hits	847
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

RON_MOUSE
NC score	0.619902 (rank : 733)	θ value	0.000786445 (rank : 948)
Query Neighborhood Hits	1580	Target Neighborhood Hits	836	Shared Neighborhood Hits	776
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

UFO_MOUSE
NC score	0.619890 (rank : 734)	θ value	0.21417 (rank : 1182)
Query Neighborhood Hits	1580	Target Neighborhood Hits	988	Shared Neighborhood Hits	855
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

ROR2_MOUSE
NC score	0.619170 (rank : 735)	θ value	7.59969e-07 (rank : 702)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1000	Shared Neighborhood Hits	909
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

VGFR2_HUMAN
NC score	0.618556 (rank : 736)	θ value	0.000270298 (rank : 908)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1103	Shared Neighborhood Hits	957
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

DDR2_HUMAN
NC score	0.616630 (rank : 737)	θ value	1.87187e-05 (rank : 806)
Query Neighborhood Hits	1580	Target Neighborhood Hits	818	Shared Neighborhood Hits	758
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

AATK_HUMAN
NC score	0.616572 (rank : 738)	θ value	0.00298849 (rank : 986)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1243	Shared Neighborhood Hits	788
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

VGFR3_MOUSE
NC score	0.616276 (rank : 739)	θ value	0.00134147 (rank : 970)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1056	Shared Neighborhood Hits	945
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

INSR_HUMAN
NC score	0.616107 (rank : 740)	θ value	0.00020696 (rank : 892)
Query Neighborhood Hits	1580	Target Neighborhood Hits	963	Shared Neighborhood Hits	814
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

TGFR2_MOUSE
NC score	0.615716 (rank : 741)	θ value	0.0563607 (rank : 1111)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	724
SwissProt Accessions	Q62312, Q63947	Gene names	Tgfbr2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

TGFR2_HUMAN
NC score	0.615520 (rank : 742)	θ value	0.0563607 (rank : 1110)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	723
SwissProt Accessions	P37173, Q15580, Q6DKT6, Q99474	Gene names	TGFBR2
Domain Architecture
Description	TGF-beta receptor type-2 precursor (EC 2.7.11.30) (TGF-beta receptor type II) (TGFR-2) (TGF-beta type II receptor).

EPHA1_MOUSE
NC score	0.615415 (rank : 743)	θ value	3.19293e-05 (rank : 831)
Query Neighborhood Hits	1580	Target Neighborhood Hits	958	Shared Neighborhood Hits	820
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

AVR2B_MOUSE
NC score	0.614988 (rank : 744)	θ value	0.00390308 (rank : 996)
Query Neighborhood Hits	1580	Target Neighborhood Hits	749	Shared Neighborhood Hits	725
SwissProt Accessions	P27040	Gene names	Acvr2b
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

AVR2B_HUMAN
NC score	0.614836 (rank : 745)	θ value	0.00390308 (rank : 995)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	725
SwissProt Accessions	Q13705, Q4VAV0	Gene names	ACVR2B
Domain Architecture
Description	Activin receptor type 2B precursor (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB).

INSR_MOUSE
NC score	0.614385 (rank : 746)	θ value	0.000270298 (rank : 902)
Query Neighborhood Hits	1580	Target Neighborhood Hits	968	Shared Neighborhood Hits	807
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

UFO_HUMAN
NC score	0.614158 (rank : 747)	θ value	0.0961366 (rank : 1139)
Query Neighborhood Hits	1580	Target Neighborhood Hits	981	Shared Neighborhood Hits	848
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

VGFR3_HUMAN
NC score	0.612749 (rank : 748)	θ value	0.00102713 (rank : 961)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1037	Shared Neighborhood Hits	938
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

MERTK_MOUSE
NC score	0.612609 (rank : 749)	θ value	0.00509761 (rank : 1004)
Query Neighborhood Hits	1580	Target Neighborhood Hits	974	Shared Neighborhood Hits	854
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MLKL_MOUSE
NC score	0.608789 (rank : 750)	θ value	θ > 10 (rank : 1923)
Query Neighborhood Hits	1580	Target Neighborhood Hits	707	Shared Neighborhood Hits	681
SwissProt Accessions	Q9D2Y4, Q8CIJ5	Gene names	Mlkl
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

AATK_MOUSE
NC score	0.606282 (rank : 751)	θ value	0.00102713 (rank : 950)
Query Neighborhood Hits	1580	Target Neighborhood Hits	942	Shared Neighborhood Hits	762
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

MERTK_HUMAN
NC score	0.605581 (rank : 752)	θ value	θ > 10 (rank : 1912)
Query Neighborhood Hits	1580	Target Neighborhood Hits	988	Shared Neighborhood Hits	871
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

SCYL2_MOUSE
NC score	0.605022 (rank : 753)	θ value	1.87187e-05 (rank : 817)
Query Neighborhood Hits	1580	Target Neighborhood Hits	603	Shared Neighborhood Hits	549
SwissProt Accessions	Q8CFE4, Q3UT57, Q3UWU9, Q8K0M4	Gene names	Scyl2, Cvak104, D10Ertd802e
Domain Architecture	No domain graphic available
Description	SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa).

PGFRA_HUMAN
NC score	0.604050 (rank : 754)	θ value	0.00035302 (rank : 914)
Query Neighborhood Hits	1580	Target Neighborhood Hits	980	Shared Neighborhood Hits	910
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

ACVR1_MOUSE
NC score	0.604015 (rank : 755)	θ value	θ > 10 (rank : 1594)
Query Neighborhood Hits	1580	Target Neighborhood Hits	768	Shared Neighborhood Hits	742
SwissProt Accessions	P37172, Q3UDH5, Q91VF1	Gene names	Acvr1, Acvrlk2, Tgfb1
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) (TSK-7L).

PGFRA_MOUSE
NC score	0.601389 (rank : 756)	θ value	0.000461057 (rank : 927)
Query Neighborhood Hits	1580	Target Neighborhood Hits	975	Shared Neighborhood Hits	900
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

IGF1R_MOUSE
NC score	0.599172 (rank : 757)	θ value	3.77169e-06 (rank : 750)
Query Neighborhood Hits	1580	Target Neighborhood Hits	973	Shared Neighborhood Hits	800
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

ACVR1_HUMAN
NC score	0.598401 (rank : 758)	θ value	θ > 10 (rank : 1593)
Query Neighborhood Hits	1580	Target Neighborhood Hits	760	Shared Neighborhood Hits	737
SwissProt Accessions	Q04771	Gene names	ACVR1, ACVRLK2
Domain Architecture
Description	Activin receptor type-1 precursor (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (Activin receptor-like kinase 2) (ALK-2) (TGF-B superfamily receptor type I) (TSR-I).

INSRR_MOUSE
NC score	0.598385 (rank : 759)	θ value	5.44631e-05 (rank : 846)
Query Neighborhood Hits	1580	Target Neighborhood Hits	961	Shared Neighborhood Hits	794
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ERBB3_MOUSE
NC score	0.597740 (rank : 760)	θ value	θ > 10 (rank : 1766)
Query Neighborhood Hits	1580	Target Neighborhood Hits	898	Shared Neighborhood Hits	761
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

KC1G2_MOUSE
NC score	0.597584 (rank : 761)	θ value	1.06291 (rank : 1281)
Query Neighborhood Hits	1580	Target Neighborhood Hits	695	Shared Neighborhood Hits	677
SwissProt Accessions	Q8BVP5	Gene names	Csnk1g2
Domain Architecture	No domain graphic available
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

IGF1R_HUMAN
NC score	0.596412 (rank : 762)	θ value	6.43352e-06 (rank : 762)
Query Neighborhood Hits	1580	Target Neighborhood Hits	977	Shared Neighborhood Hits	802
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

INSRR_HUMAN
NC score	0.595536 (rank : 763)	θ value	1.09739e-05 (rank : 784)
Query Neighborhood Hits	1580	Target Neighborhood Hits	950	Shared Neighborhood Hits	792
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

KC1G2_HUMAN
NC score	0.595083 (rank : 764)	θ value	2.36792 (rank : 1360)
Query Neighborhood Hits	1580	Target Neighborhood Hits	693	Shared Neighborhood Hits	677
SwissProt Accessions	P78368, O00704, Q8WUB1	Gene names	CSNK1G2
Domain Architecture
Description	Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma 2).

ERBB3_HUMAN
NC score	0.594821 (rank : 765)	θ value	θ > 10 (rank : 1765)
Query Neighborhood Hits	1580	Target Neighborhood Hits	918	Shared Neighborhood Hits	756
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

BMR1A_HUMAN
NC score	0.593852 (rank : 766)	θ value	5.27518 (rank : 1444)
Query Neighborhood Hits	1580	Target Neighborhood Hits	759	Shared Neighborhood Hits	731
SwissProt Accessions	P36894, Q8NEN8	Gene names	BMPR1A, ACVRLK3, ALK3
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (CD292 antigen).

PGFRB_MOUSE
NC score	0.593595 (rank : 767)	θ value	0.0736092 (rank : 1121)
Query Neighborhood Hits	1580	Target Neighborhood Hits	960	Shared Neighborhood Hits	892
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_HUMAN
NC score	0.593048 (rank : 768)	θ value	0.0252991 (rank : 1073)
Query Neighborhood Hits	1580	Target Neighborhood Hits	962	Shared Neighborhood Hits	895
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

BMR1A_MOUSE
NC score	0.592876 (rank : 769)	θ value	5.27518 (rank : 1445)
Query Neighborhood Hits	1580	Target Neighborhood Hits	758	Shared Neighborhood Hits	732
SwissProt Accessions	P36895	Gene names	Bmpr1a, Acvrlk3, Bmpr
Domain Architecture
Description	Bone morphogenetic protein receptor type IA precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R5) (SKR5) (Activin receptor-like kinase 3) (ALK-3) (BMP-2/BMP-4 receptor).

DDR1_MOUSE
NC score	0.592358 (rank : 770)	θ value	7.1131e-05 (rank : 851)
Query Neighborhood Hits	1580	Target Neighborhood Hits	818	Shared Neighborhood Hits	752
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

IRAK3_HUMAN
NC score	0.591080 (rank : 771)	θ value	0.00869519 (rank : 1029)
Query Neighborhood Hits	1580	Target Neighborhood Hits	644	Shared Neighborhood Hits	613
SwissProt Accessions	Q9Y616	Gene names	IRAK3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

DDR1_HUMAN
NC score	0.590153 (rank : 772)	θ value	0.000121331 (rank : 870)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	757
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

KIT_HUMAN
NC score	0.589390 (rank : 773)	θ value	0.00665767 (rank : 1016)
Query Neighborhood Hits	1580	Target Neighborhood Hits	953	Shared Neighborhood Hits	896
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

TGFR1_HUMAN
NC score	0.589276 (rank : 774)	θ value	0.00869519 (rank : 1033)
Query Neighborhood Hits	1580	Target Neighborhood Hits	755	Shared Neighborhood Hits	730
SwissProt Accessions	P36897	Gene names	TGFBR1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (Serine/threonine-protein kinase receptor R4) (SKR4) (Activin receptor-like kinase 5) (ALK-5).

TGFR1_MOUSE
NC score	0.589005 (rank : 775)	θ value	0.00869519 (rank : 1034)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	730
SwissProt Accessions	Q64729	Gene names	Tgfbr1
Domain Architecture
Description	TGF-beta receptor type-1 precursor (EC 2.7.11.30) (TGF-beta receptor type I) (TGFR-1) (TGF-beta type I receptor) (ESK2).

KIT_MOUSE
NC score	0.588521 (rank : 776)	θ value	0.00665767 (rank : 1017)
Query Neighborhood Hits	1580	Target Neighborhood Hits	949	Shared Neighborhood Hits	901
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

BUB1_MOUSE
NC score	0.588464 (rank : 777)	θ value	0.00228821 (rank : 979)
Query Neighborhood Hits	1580	Target Neighborhood Hits	583	Shared Neighborhood Hits	542
SwissProt Accessions	O08901, O09007	Gene names	Bub1
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (MBUB1) (BUB1A).

IRAK3_MOUSE
NC score	0.588014 (rank : 778)	θ value	0.000602161 (rank : 933)
Query Neighborhood Hits	1580	Target Neighborhood Hits	628	Shared Neighborhood Hits	591
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ACV1B_MOUSE
NC score	0.585914 (rank : 779)	θ value	0.00869519 (rank : 1022)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	732
SwissProt Accessions	Q61271	Gene names	Acvr1b
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2).

ACV1B_HUMAN
NC score	0.585733 (rank : 780)	θ value	0.00869519 (rank : 1021)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	733
SwissProt Accessions	P36896, Q15479, Q15480, Q15481, Q15482	Gene names	ACVR1B, ACVRLK4
Domain Architecture
Description	Activin receptor type 1B precursor (EC 2.7.11.30) (ACTR-IB) (Serine/threonine-protein kinase receptor R2) (SKR2) (Activin receptor-like kinase 4) (ALK-4).

EPHA6_MOUSE
NC score	0.584435 (rank : 781)	θ value	9.29e-05 (rank : 864)
Query Neighborhood Hits	1580	Target Neighborhood Hits	946	Shared Neighborhood Hits	822
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ANKK1_MOUSE
NC score	0.583941 (rank : 782)	θ value	0.00228821 (rank : 977)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1072	Shared Neighborhood Hits	778
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

EPHA6_HUMAN
NC score	0.580836 (rank : 783)	θ value	0.000121331 (rank : 872)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	825
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ALK_HUMAN
NC score	0.579459 (rank : 784)	θ value	0.365318 (rank : 1203)
Query Neighborhood Hits	1580	Target Neighborhood Hits	795	Shared Neighborhood Hits	719
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

BMR1B_MOUSE
NC score	0.578822 (rank : 785)	θ value	θ > 10 (rank : 1633)
Query Neighborhood Hits	1580	Target Neighborhood Hits	758	Shared Neighborhood Hits	728
SwissProt Accessions	P36898, Q3TRF2	Gene names	Bmpr1b, Acvrlk6
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R6) (SKR6) (Activin receptor-like kinase 6) (ALK-6).

LTK_MOUSE
NC score	0.577831 (rank : 786)	θ value	0.00869519 (rank : 1030)
Query Neighborhood Hits	1580	Target Neighborhood Hits	770	Shared Neighborhood Hits	721
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

BMR1B_HUMAN
NC score	0.577576 (rank : 787)	θ value	θ > 10 (rank : 1632)
Query Neighborhood Hits	1580	Target Neighborhood Hits	760	Shared Neighborhood Hits	727
SwissProt Accessions	O00238, P78366	Gene names	BMPR1B
Domain Architecture
Description	Bone morphogenetic protein receptor type IB precursor (EC 2.7.11.30) (CDw293 antigen).

ALK_MOUSE
NC score	0.577149 (rank : 788)	θ value	0.125558 (rank : 1140)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	726
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ANKK1_HUMAN
NC score	0.573759 (rank : 789)	θ value	0.00228821 (rank : 976)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1075	Shared Neighborhood Hits	772
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

FLT3_HUMAN
NC score	0.572664 (rank : 790)	θ value	0.000158464 (rank : 878)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	808
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
NC score	0.572345 (rank : 791)	θ value	4.1701e-05 (rank : 838)
Query Neighborhood Hits	1580	Target Neighborhood Hits	847	Shared Neighborhood Hits	819
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

RIPK4_HUMAN
NC score	0.571852 (rank : 792)	θ value	0.0961366 (rank : 1137)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1094	Shared Neighborhood Hits	781
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

LTK_HUMAN
NC score	0.569974 (rank : 793)	θ value	0.0431538 (rank : 1092)
Query Neighborhood Hits	1580	Target Neighborhood Hits	774	Shared Neighborhood Hits	730
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

TOPK_MOUSE
NC score	0.568758 (rank : 794)	θ value	0.00509761 (rank : 1009)
Query Neighborhood Hits	1580	Target Neighborhood Hits	618	Shared Neighborhood Hits	587
SwissProt Accessions	Q9JJ78, Q922V2, Q9D184	Gene names	Pbk, Topk
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase).

BMPR2_HUMAN
NC score	0.565576 (rank : 795)	θ value	θ > 10 (rank : 1630)
Query Neighborhood Hits	1580	Target Neighborhood Hits	736	Shared Neighborhood Hits	691
SwissProt Accessions	Q13873, Q16569	Gene names	BMPR2, PPH1
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II).

BMPR2_MOUSE
NC score	0.564433 (rank : 796)	θ value	θ > 10 (rank : 1631)
Query Neighborhood Hits	1580	Target Neighborhood Hits	738	Shared Neighborhood Hits	691
SwissProt Accessions	O35607	Gene names	Bmpr2
Domain Architecture
Description	Bone morphogenetic protein receptor type-2 precursor (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II) (BRK-3).

CSF1R_MOUSE
NC score	0.563494 (rank : 797)	θ value	0.0431538 (rank : 1087)
Query Neighborhood Hits	1580	Target Neighborhood Hits	983	Shared Neighborhood Hits	912
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

TOPK_HUMAN
NC score	0.560708 (rank : 798)	θ value	0.62314 (rank : 1246)
Query Neighborhood Hits	1580	Target Neighborhood Hits	605	Shared Neighborhood Hits	576
SwissProt Accessions	Q96KB5, Q9NPD9, Q9NYL7, Q9NZK6	Gene names	PBK, TOPK
Domain Architecture	No domain graphic available
Description	T-lymphokine-activated killer cell-originated protein kinase (EC 2.7.12.2) (T-LAK cell-originated protein kinase) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (MAPKK-like protein kinase) (Nori-3).

SRPK2_MOUSE
NC score	0.559064 (rank : 799)	θ value	2.21117e-06 (rank : 736)
Query Neighborhood Hits	1580	Target Neighborhood Hits	765	Shared Neighborhood Hits	646
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

CSF1R_HUMAN
NC score	0.558510 (rank : 800)	θ value	0.0431538 (rank : 1086)
Query Neighborhood Hits	1580	Target Neighborhood Hits	943	Shared Neighborhood Hits	891
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ACVL1_MOUSE
NC score	0.558480 (rank : 801)	θ value	θ > 10 (rank : 1592)
Query Neighborhood Hits	1580	Target Neighborhood Hits	739	Shared Neighborhood Hits	718
SwissProt Accessions	Q61288, Q61289	Gene names	Acvrl1, Acvrlk1, Alk-1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

SRPK2_HUMAN
NC score	0.554824 (rank : 802)	θ value	2.21117e-06 (rank : 735)
Query Neighborhood Hits	1580	Target Neighborhood Hits	664	Shared Neighborhood Hits	599
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK1_MOUSE
NC score	0.552037 (rank : 803)	θ value	4.92598e-06 (rank : 761)
Query Neighborhood Hits	1580	Target Neighborhood Hits	639	Shared Neighborhood Hits	574
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK1_HUMAN
NC score	0.551192 (rank : 804)	θ value	4.92598e-06 (rank : 760)
Query Neighborhood Hits	1580	Target Neighborhood Hits	706	Shared Neighborhood Hits	592
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

STK23_MOUSE
NC score	0.549701 (rank : 805)	θ value	3.77169e-06 (rank : 755)
Query Neighborhood Hits	1580	Target Neighborhood Hits	572	Shared Neighborhood Hits	554
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_HUMAN
NC score	0.549339 (rank : 806)	θ value	3.77169e-06 (rank : 754)
Query Neighborhood Hits	1580	Target Neighborhood Hits	556	Shared Neighborhood Hits	549
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

ACVL1_HUMAN
NC score	0.538606 (rank : 807)	θ value	θ > 10 (rank : 1591)
Query Neighborhood Hits	1580	Target Neighborhood Hits	716	Shared Neighborhood Hits	695
SwissProt Accessions	P37023	Gene names	ACVRL1, ACVRLK1, ALK1
Domain Architecture
Description	Serine/threonine-protein kinase receptor R3 precursor (EC 2.7.11.30) (SKR3) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I).

EPHB6_MOUSE
NC score	0.538497 (rank : 808)	θ value	8.40245e-06 (rank : 769)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	746
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPHAA_HUMAN
NC score	0.531084 (rank : 809)	θ value	0.000461057 (rank : 923)
Query Neighborhood Hits	1580	Target Neighborhood Hits	960	Shared Neighborhood Hits	769
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

ACV1C_MOUSE
NC score	0.526649 (rank : 810)	θ value	0.21417 (rank : 1167)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	687
SwissProt Accessions	Q8K348	Gene names	Acvr1c, Alk7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

EPHB6_HUMAN
NC score	0.523876 (rank : 811)	θ value	1.87187e-05 (rank : 809)
Query Neighborhood Hits	1580	Target Neighborhood Hits	912	Shared Neighborhood Hits	725
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

ACV1C_HUMAN
NC score	0.522367 (rank : 812)	θ value	0.279714 (rank : 1183)
Query Neighborhood Hits	1580	Target Neighborhood Hits	709	Shared Neighborhood Hits	681
SwissProt Accessions	Q8NER5, Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2	Gene names	ACVR1C, ALK7
Domain Architecture	No domain graphic available
Description	Activin receptor type 1C precursor (EC 2.7.11.30) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7).

RYK_MOUSE
NC score	0.519417 (rank : 813)	θ value	0.0431538 (rank : 1097)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	686
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

MLKL_HUMAN
NC score	0.515600 (rank : 814)	θ value	2.36792 (rank : 1363)
Query Neighborhood Hits	1580	Target Neighborhood Hits	600	Shared Neighborhood Hits	576
SwissProt Accessions	Q8NB16, Q8N6V0	Gene names	MLKL
Domain Architecture	No domain graphic available
Description	Mixed lineage kinase domain-like protein.

RYK_HUMAN
NC score	0.505191 (rank : 815)	θ value	0.0431538 (rank : 1096)
Query Neighborhood Hits	1580	Target Neighborhood Hits	701	Shared Neighborhood Hits	675
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

GUC2F_HUMAN
NC score	0.494099 (rank : 816)	θ value	0.125558 (rank : 1144)
Query Neighborhood Hits	1580	Target Neighborhood Hits	740	Shared Neighborhood Hits	667
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

AMHR2_HUMAN
NC score	0.478793 (rank : 817)	θ value	θ > 10 (rank : 1599)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	647
SwissProt Accessions	Q16671, Q13762	Gene names	AMHR2, AMHR
Domain Architecture
Description	Anti-Muellerian hormone type-2 receptor precursor (EC 2.7.11.30) (Anti-Muellerian hormone type II receptor) (AMH type II receptor) (MIS type II receptor) (MISRII) (MRII).

TEX14_MOUSE
NC score	0.477037 (rank : 818)	θ value	3.0926 (rank : 1409)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1333	Shared Neighborhood Hits	780
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

NRBP_HUMAN
NC score	0.451435 (rank : 819)	θ value	6.88961 (rank : 1500)
Query Neighborhood Hits	1580	Target Neighborhood Hits	448	Shared Neighborhood Hits	414
SwissProt Accessions	Q9UHY1, Q53FZ5, Q96SU3	Gene names	NRBP1, BCON3, NRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein.

GUC2D_HUMAN
NC score	0.449654 (rank : 820)	θ value	0.125558 (rank : 1143)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	653
SwissProt Accessions	Q02846, Q6LEA7	Gene names	GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1
Domain Architecture
Description	Retinal guanylyl cyclase 1 precursor (EC 4.6.1.2) (Guanylate cyclase 2D, retinal) (RETGC-1) (Rod outer segment membrane guanylate cyclase) (ROS-GC).

NRBP_MOUSE
NC score	0.449235 (rank : 821)	θ value	5.27518 (rank : 1464)
Query Neighborhood Hits	1580	Target Neighborhood Hits	442	Shared Neighborhood Hits	410
SwissProt Accessions	Q99J45, Q8BL77	Gene names	Nrbp1, Madm, Nrbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding protein (MLF1 adapter molecule) (HLS7- interacting protein kinase).

VRK2_MOUSE
NC score	0.444339 (rank : 822)	θ value	θ > 10 (rank : 2204)
Query Neighborhood Hits	1580	Target Neighborhood Hits	586	Shared Neighborhood Hits	563
SwissProt Accessions	Q8BN21, Q5F1Z5, Q5SP88, Q8BPU8, Q8CJ46, Q91WS1, Q9CZF9	Gene names	Vrk2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

GUC2C_HUMAN
NC score	0.440263 (rank : 823)	θ value	θ > 10 (rank : 1806)
Query Neighborhood Hits	1580	Target Neighborhood Hits	624	Shared Neighborhood Hits	572
SwissProt Accessions	P25092	Gene names	GUCY2C, GUC2C, STAR
Domain Architecture
Description	Heat-stable enterotoxin receptor precursor (GC-C) (Intestinal guanylate cyclase) (EC 4.6.1.2) (STA receptor) (hSTAR).

VRK2_HUMAN
NC score	0.438917 (rank : 824)	θ value	θ > 10 (rank : 2203)
Query Neighborhood Hits	1580	Target Neighborhood Hits	582	Shared Neighborhood Hits	550
SwissProt Accessions	Q86Y07, Q49AK9, Q53EU9, Q86Y08, Q86Y09, Q86Y10, Q86Y11, Q86Y12, Q8IXI5, Q99987	Gene names	VRK2
Domain Architecture
Description	Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2).

VRK1_MOUSE
NC score	0.435954 (rank : 825)	θ value	θ > 10 (rank : 2202)
Query Neighborhood Hits	1580	Target Neighborhood Hits	583	Shared Neighborhood Hits	564
SwissProt Accessions	Q80X41, O88635, O88636, Q8C2P7, Q91YH9	Gene names	Vrk1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK).

ANPRB_HUMAN
NC score	0.433941 (rank : 826)	θ value	6.87365e-08 (rank : 627)
Query Neighborhood Hits	1580	Target Neighborhood Hits	646	Shared Neighborhood Hits	568
SwissProt Accessions	P20594, O60871, Q9UQ50	Gene names	NPR2, ANPRB
Domain Architecture
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

VRK1_HUMAN
NC score	0.431474 (rank : 827)	θ value	θ > 10 (rank : 2201)
Query Neighborhood Hits	1580	Target Neighborhood Hits	584	Shared Neighborhood Hits	563
SwissProt Accessions	Q99986	Gene names	VRK1
Domain Architecture
Description	Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1).

GUC2E_MOUSE
NC score	0.426256 (rank : 828)	θ value	0.00390308 (rank : 999)
Query Neighborhood Hits	1580	Target Neighborhood Hits	692	Shared Neighborhood Hits	628
SwissProt Accessions	P52785	Gene names	Gucy2e, Guc2e
Domain Architecture
Description	Guanylyl cyclase GC-E precursor (EC 4.6.1.2) (Guanylate cyclase 2E).

GUC2G_MOUSE
NC score	0.422398 (rank : 829)	θ value	0.62314 (rank : 1237)
Query Neighborhood Hits	1580	Target Neighborhood Hits	644	Shared Neighborhood Hits	569
SwissProt Accessions	Q6TL19, Q8BWU7	Gene names	Gucy2g
Domain Architecture	No domain graphic available
Description	Guanylate cyclase 2G precursor (EC 4.6.1.2) (Guanylyl cyclase receptor G) (mGC-G).

TEX14_HUMAN
NC score	0.422265 (rank : 830)	θ value	3.0926 (rank : 1408)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1103	Shared Neighborhood Hits	634
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

BUB1_HUMAN
NC score	0.416418 (rank : 831)	θ value	0.0736092 (rank : 1113)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	415
SwissProt Accessions	O43683, O43430, O43643, O60626	Gene names	BUB1, BUB1L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC 2.7.11.1) (hBUB1) (BUB1A).

ANPRB_MOUSE
NC score	0.407017 (rank : 832)	θ value	9.92553e-07 (rank : 704)
Query Neighborhood Hits	1580	Target Neighborhood Hits	607	Shared Neighborhood Hits	543
SwissProt Accessions	Q6VVW5, Q6VVW3, Q6VVW4, Q8CGA9	Gene names	Npr2
Domain Architecture	No domain graphic available
Description	Atrial natriuretic peptide receptor B precursor (ANP-B) (ANPRB) (GC-B) (Guanylate cyclase B) (EC 4.6.1.2) (NPR-B) (Atrial natriuretic peptide B-type receptor).

ILK1_HUMAN
NC score	0.400847 (rank : 833)	θ value	0.0193708 (rank : 1058)
Query Neighborhood Hits	1580	Target Neighborhood Hits	857	Shared Neighborhood Hits	574
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.398448 (rank : 834)	θ value	0.0252991 (rank : 1070)
Query Neighborhood Hits	1580	Target Neighborhood Hits	858	Shared Neighborhood Hits	575
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ANPRA_HUMAN
NC score	0.393603 (rank : 835)	θ value	θ > 10 (rank : 1606)
Query Neighborhood Hits	1580	Target Neighborhood Hits	612	Shared Neighborhood Hits	533
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANPRA_MOUSE
NC score	0.393380 (rank : 836)	θ value	θ > 10 (rank : 1607)
Query Neighborhood Hits	1580	Target Neighborhood Hits	600	Shared Neighborhood Hits	527
SwissProt Accessions	P18293	Gene names	Npr1, Npra
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ILK2_HUMAN
NC score	0.388602 (rank : 837)	θ value	0.125558 (rank : 1145)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	568
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

HAPIP_HUMAN
NC score	0.385302 (rank : 838)	θ value	0 (rank : 1)
Query Neighborhood Hits	1580	Target Neighborhood Hits	350	Shared Neighborhood Hits	250
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

STK31_HUMAN
NC score	0.369575 (rank : 839)	θ value	1.06291 (rank : 1291)
Query Neighborhood Hits	1580	Target Neighborhood Hits	570	Shared Neighborhood Hits	481
SwissProt Accessions	Q9BXU1, Q9BXH8	Gene names	STK31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine- protein kinase NYD-SPK).

PI3R4_MOUSE
NC score	0.359673 (rank : 840)	θ value	θ > 10 (rank : 2008)
Query Neighborhood Hits	1580	Target Neighborhood Hits	535	Shared Neighborhood Hits	352
SwissProt Accessions	Q8VD65, Q56A65, Q8C948, Q8C9D7, Q9CVC5	Gene names	Pik3r4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4).

PI3R4_HUMAN
NC score	0.346678 (rank : 841)	θ value	θ > 10 (rank : 2007)
Query Neighborhood Hits	1580	Target Neighborhood Hits	534	Shared Neighborhood Hits	347
SwissProt Accessions	Q99570	Gene names	PIK3R4
Domain Architecture	No domain graphic available
Description	Phosphoinositide 3-kinase regulatory subunit 4 (EC 2.7.11.1) (PI3- kinase regulatory subunit 4) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein).

NTKL_MOUSE
NC score	0.344969 (rank : 842)	θ value	θ > 10 (rank : 1974)
Query Neighborhood Hits	1580	Target Neighborhood Hits	326	Shared Neighborhood Hits	294
SwissProt Accessions	Q9EQC5, Q3TST7, Q3UKU0, Q8K222	Gene names	Scyl1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (105 kDa kinase- like protein) (Mitosis-associated kinase-like protein NTKL).

K2002_HUMAN
NC score	0.337161 (rank : 843)	θ value	1.81305 (rank : 1331)
Query Neighborhood Hits	1580	Target Neighborhood Hits	274	Shared Neighborhood Hits	261
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

MCF2L_MOUSE
NC score	0.324815 (rank : 844)	θ value	6.56568e-51 (rank : 12)
Query Neighborhood Hits	1580	Target Neighborhood Hits	255	Shared Neighborhood Hits	173
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

STK31_MOUSE
NC score	0.318899 (rank : 845)	θ value	8.99809 (rank : 1569)
Query Neighborhood Hits	1580	Target Neighborhood Hits	474	Shared Neighborhood Hits	410
SwissProt Accessions	Q99MW1	Gene names	Stk31
Domain Architecture
Description	Serine/threonine-protein kinase 31 (EC 2.7.11.1).

MCF2_HUMAN
NC score	0.309259 (rank : 846)	θ value	1.72781e-51 (rank : 10)
Query Neighborhood Hits	1580	Target Neighborhood Hits	166	Shared Neighborhood Hits	130
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

RN5A_MOUSE
NC score	0.308648 (rank : 847)	θ value	0.0563607 (rank : 1109)
Query Neighborhood Hits	1580	Target Neighborhood Hits	899	Shared Neighborhood Hits	603
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

K2002_MOUSE
NC score	0.280025 (rank : 848)	θ value	5.27518 (rank : 1458)
Query Neighborhood Hits	1580	Target Neighborhood Hits	267	Shared Neighborhood Hits	235
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

PKHG4_HUMAN
NC score	0.279825 (rank : 849)	θ value	2.1121e-49 (rank : 13)
Query Neighborhood Hits	1580	Target Neighborhood Hits	200	Shared Neighborhood Hits	75
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PKHG1_HUMAN
NC score	0.276150 (rank : 850)	θ value	2.59387e-31 (rank : 51)
Query Neighborhood Hits	1580	Target Neighborhood Hits	174	Shared Neighborhood Hits	87
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

NTKL_HUMAN
NC score	0.264970 (rank : 851)	θ value	θ > 10 (rank : 1973)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	226
SwissProt Accessions	Q96KG9, Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53	Gene names	SCYL1, GKLP, NTKL, TAPK, TEIF, TRAP
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like protein (SCY1-like protein 1) (Teratoma- associated tyrosine kinase) (Telomerase transcriptional element- interacting factor) (Telomerase regulation-associated protein).

ARHG4_HUMAN
NC score	0.248918 (rank : 852)	θ value	1.24977e-17 (rank : 275)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	126
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
NC score	0.246767 (rank : 853)	θ value	8.10077e-17 (rank : 298)
Query Neighborhood Hits	1580	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
NC score	0.246609 (rank : 854)	θ value	1.99529e-15 (rank : 340)
Query Neighborhood Hits	1580	Target Neighborhood Hits	235	Shared Neighborhood Hits	124
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.246550 (rank : 855)	θ value	2.60593e-15 (rank : 344)
Query Neighborhood Hits	1580	Target Neighborhood Hits	234	Shared Neighborhood Hits	123
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

VAV_HUMAN
NC score	0.244705 (rank : 856)	θ value	1.58096e-12 (rank : 423)
Query Neighborhood Hits	1580	Target Neighborhood Hits	452	Shared Neighborhood Hits	198
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
NC score	0.242709 (rank : 857)	θ value	1.86753e-13 (rank : 393)
Query Neighborhood Hits	1580	Target Neighborhood Hits	430	Shared Neighborhood Hits	193
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VRK3_HUMAN
NC score	0.241714 (rank : 858)	θ value	θ > 10 (rank : 2205)
Query Neighborhood Hits	1580	Target Neighborhood Hits	349	Shared Neighborhood Hits	306
SwissProt Accessions	Q8IV63, Q9P2V8	Gene names	VRK3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

VAV3_HUMAN
NC score	0.239471 (rank : 859)	θ value	1.06045e-08 (rank : 592)
Query Neighborhood Hits	1580	Target Neighborhood Hits	398	Shared Neighborhood Hits	184
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PREX1_HUMAN
NC score	0.239269 (rank : 860)	θ value	3.63628e-17 (rank : 288)
Query Neighborhood Hits	1580	Target Neighborhood Hits	177	Shared Neighborhood Hits	84
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

VAV2_HUMAN
NC score	0.239041 (rank : 861)	θ value	9.26847e-13 (rank : 411)
Query Neighborhood Hits	1580	Target Neighborhood Hits	453	Shared Neighborhood Hits	200
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.238956 (rank : 862)	θ value	9.59137e-10 (rank : 534)
Query Neighborhood Hits	1580	Target Neighborhood Hits	404	Shared Neighborhood Hits	186
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV2_MOUSE
NC score	0.237074 (rank : 863)	θ value	2.69671e-12 (rank : 433)
Query Neighborhood Hits	1580	Target Neighborhood Hits	456	Shared Neighborhood Hits	196
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ITSN2_HUMAN
NC score	0.233124 (rank : 864)	θ value	4.76016e-09 (rank : 570)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1173	Shared Neighborhood Hits	420
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

SPTA1_HUMAN
NC score	0.232970 (rank : 865)	θ value	8.63488e-27 (rank : 104)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	341
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
NC score	0.231322 (rank : 866)	θ value	2.27234e-27 (rank : 93)
Query Neighborhood Hits	1580	Target Neighborhood Hits	888	Shared Neighborhood Hits	355
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

FGD3_MOUSE
NC score	0.230447 (rank : 867)	θ value	4.58923e-20 (rank : 199)
Query Neighborhood Hits	1580	Target Neighborhood Hits	257	Shared Neighborhood Hits	99
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

SPTA1_MOUSE
NC score	0.230378 (rank : 868)	θ value	1.12775e-26 (rank : 105)
Query Neighborhood Hits	1580	Target Neighborhood Hits	675	Shared Neighborhood Hits	314
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

TIAM1_MOUSE
NC score	0.229642 (rank : 869)	θ value	2.35696e-16 (rank : 316)
Query Neighborhood Hits	1580	Target Neighborhood Hits	205	Shared Neighborhood Hits	91
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ITSN2_MOUSE
NC score	0.229548 (rank : 870)	θ value	5.26297e-08 (rank : 622)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1371	Shared Neighborhood Hits	447
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.228624 (rank : 871)	θ value	4.76016e-09 (rank : 569)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1757	Shared Neighborhood Hits	492
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.228514 (rank : 872)	θ value	6.21693e-09 (rank : 578)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1669	Shared Neighborhood Hits	490
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

TIAM1_HUMAN
NC score	0.225975 (rank : 873)	θ value	6.20254e-17 (rank : 297)
Query Neighborhood Hits	1580	Target Neighborhood Hits	225	Shared Neighborhood Hits	96
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG7_MOUSE
NC score	0.225422 (rank : 874)	θ value	1.42992e-13 (rank : 385)
Query Neighborhood Hits	1580	Target Neighborhood Hits	396	Shared Neighborhood Hits	202
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG7_HUMAN
NC score	0.223269 (rank : 875)	θ value	1.68911e-14 (rank : 368)
Query Neighborhood Hits	1580	Target Neighborhood Hits	347	Shared Neighborhood Hits	159
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG6_HUMAN
NC score	0.220381 (rank : 876)	θ value	1.38178e-16 (rank : 305)
Query Neighborhood Hits	1580	Target Neighborhood Hits	376	Shared Neighborhood Hits	186
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

FGD3_HUMAN
NC score	0.219799 (rank : 877)	θ value	6.85773e-16 (rank : 327)
Query Neighborhood Hits	1580	Target Neighborhood Hits	249	Shared Neighborhood Hits	92
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD4_HUMAN
NC score	0.218559 (rank : 878)	θ value	5.60996e-18 (rank : 264)
Query Neighborhood Hits	1580	Target Neighborhood Hits	219	Shared Neighborhood Hits	108
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.218506 (rank : 879)	θ value	4.74913e-17 (rank : 291)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	105
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

DNMBP_HUMAN
NC score	0.216672 (rank : 880)	θ value	3.76295e-14 (rank : 379)
Query Neighborhood Hits	1580	Target Neighborhood Hits	413	Shared Neighborhood Hits	193
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VRK3_MOUSE
NC score	0.215858 (rank : 881)	θ value	θ > 10 (rank : 2206)
Query Neighborhood Hits	1580	Target Neighborhood Hits	342	Shared Neighborhood Hits	314
SwissProt Accessions	Q8K3G5, Q921W6	Gene names	Vrk3
Domain Architecture
Description	Serine/threonine-protein kinase VRK3 (EC 2.7.11.1) (Vaccinia-related kinase 3).

FGD2_HUMAN
NC score	0.215053 (rank : 882)	θ value	2.60593e-15 (rank : 345)
Query Neighborhood Hits	1580	Target Neighborhood Hits	151	Shared Neighborhood Hits	83
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

ARHG6_MOUSE
NC score	0.213660 (rank : 883)	θ value	9.90251e-15 (rank : 365)
Query Neighborhood Hits	1580	Target Neighborhood Hits	394	Shared Neighborhood Hits	198
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

FGD2_MOUSE
NC score	0.213519 (rank : 884)	θ value	3.40345e-15 (rank : 348)
Query Neighborhood Hits	1580	Target Neighborhood Hits	163	Shared Neighborhood Hits	88
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

DNMBP_MOUSE
NC score	0.209764 (rank : 885)	θ value	3.52202e-12 (rank : 434)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	190
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FGD1_MOUSE
NC score	0.207397 (rank : 886)	θ value	1.38178e-16 (rank : 306)
Query Neighborhood Hits	1580	Target Neighborhood Hits	387	Shared Neighborhood Hits	126
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_HUMAN
NC score	0.205796 (rank : 887)	θ value	5.25075e-16 (rank : 325)
Query Neighborhood Hits	1580	Target Neighborhood Hits	367	Shared Neighborhood Hits	124
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MYPN_HUMAN
NC score	0.203937 (rank : 888)	θ value	1.43324e-05 (rank : 798)
Query Neighborhood Hits	1580	Target Neighborhood Hits	418	Shared Neighborhood Hits	254
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

MYPN_MOUSE
NC score	0.203318 (rank : 889)	θ value	1.87187e-05 (rank : 816)
Query Neighborhood Hits	1580	Target Neighborhood Hits	421	Shared Neighborhood Hits	245
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

OBSL1_HUMAN
NC score	0.202541 (rank : 890)	θ value	0.0148317 (rank : 1052)
Query Neighborhood Hits	1580	Target Neighborhood Hits	354	Shared Neighborhood Hits	235
SwissProt Accessions	O75147, Q96IW3	Gene names	OBSL1, KIAA0657
Domain Architecture	No domain graphic available
Description	Obscurin-like protein 1 precursor.

ECT2_MOUSE
NC score	0.202455 (rank : 891)	θ value	8.11959e-09 (rank : 586)
Query Neighborhood Hits	1580	Target Neighborhood Hits	98	Shared Neighborhood Hits	77
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SPTB2_HUMAN
NC score	0.200179 (rank : 892)	θ value	4.9032e-22 (rank : 165)
Query Neighborhood Hits	1580	Target Neighborhood Hits	748	Shared Neighborhood Hits	302
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MYOTI_HUMAN
NC score	0.199775 (rank : 893)	θ value	0.000786445 (rank : 944)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	223
SwissProt Accessions	Q9UBF9	Gene names	MYOT, TTID
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein) (57 kDa cytoskeletal protein).

ARHG8_HUMAN
NC score	0.199457 (rank : 894)	θ value	1.33837e-11 (rank : 457)
Query Neighborhood Hits	1580	Target Neighborhood Hits	85	Shared Neighborhood Hits	73
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

SPTB2_MOUSE
NC score	0.199301 (rank : 895)	θ value	2.20094e-22 (rank : 158)
Query Neighborhood Hits	1580	Target Neighborhood Hits	770	Shared Neighborhood Hits	305
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

MYOTI_MOUSE
NC score	0.199009 (rank : 896)	θ value	4.1701e-05 (rank : 841)
Query Neighborhood Hits	1580	Target Neighborhood Hits	297	Shared Neighborhood Hits	215
SwissProt Accessions	Q9JIF9	Gene names	Myot, Ttid
Domain Architecture	No domain graphic available
Description	Myotilin (Titin immunoglobulin domain protein) (Myofibrillar titin- like Ig domains protein).

ROBO1_HUMAN
NC score	0.198716 (rank : 897)	θ value	8.40245e-06 (rank : 774)
Query Neighborhood Hits	1580	Target Neighborhood Hits	529	Shared Neighborhood Hits	285
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ROBO1_MOUSE
NC score	0.198518 (rank : 898)	θ value	8.40245e-06 (rank : 775)
Query Neighborhood Hits	1580	Target Neighborhood Hits	559	Shared Neighborhood Hits	286
SwissProt Accessions	O89026	Gene names	Robo1, Dutt1
Domain Architecture
Description	Roundabout homolog 1 precursor.

ARHG3_HUMAN
NC score	0.198488 (rank : 899)	θ value	3.29651e-10 (rank : 505)
Query Neighborhood Hits	1580	Target Neighborhood Hits	82	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ROBO2_MOUSE
NC score	0.198163 (rank : 900)	θ value	7.59969e-07 (rank : 701)
Query Neighborhood Hits	1580	Target Neighborhood Hits	504	Shared Neighborhood Hits	282
SwissProt Accessions	Q7TPD3, Q8BJ59	Gene names	Robo2, Kiaa1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ROBO2_HUMAN
NC score	0.197959 (rank : 901)	θ value	3.41135e-07 (rank : 672)
Query Neighborhood Hits	1580	Target Neighborhood Hits	479	Shared Neighborhood Hits	270
SwissProt Accessions	Q9HCK4, O43608	Gene names	ROBO2, KIAA1568
Domain Architecture
Description	Roundabout homolog 2 precursor.

ECT2_HUMAN
NC score	0.197513 (rank : 902)	θ value	3.08544e-08 (rank : 612)
Query Neighborhood Hits	1580	Target Neighborhood Hits	98	Shared Neighborhood Hits	78
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ROBO3_HUMAN
NC score	0.196800 (rank : 903)	θ value	8.40245e-06 (rank : 776)
Query Neighborhood Hits	1580	Target Neighborhood Hits	570	Shared Neighborhood Hits	294
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

NEO1_MOUSE
NC score	0.196103 (rank : 904)	θ value	3.41135e-07 (rank : 671)
Query Neighborhood Hits	1580	Target Neighborhood Hits	523	Shared Neighborhood Hits	284
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

ARHG3_MOUSE
NC score	0.195731 (rank : 905)	θ value	2.13673e-09 (rank : 550)
Query Neighborhood Hits	1580	Target Neighborhood Hits	85	Shared Neighborhood Hits	67
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

NEO1_HUMAN
NC score	0.195270 (rank : 906)	θ value	1.69304e-06 (rank : 727)
Query Neighborhood Hits	1580	Target Neighborhood Hits	530	Shared Neighborhood Hits	279
SwissProt Accessions	Q92859, O00340	Gene names	NEO1, NGN
Domain Architecture
Description	Neogenin precursor.

PUNC_MOUSE
NC score	0.195213 (rank : 907)	θ value	1.17247e-07 (rank : 645)
Query Neighborhood Hits	1580	Target Neighborhood Hits	501	Shared Neighborhood Hits	257
SwissProt Accessions	Q8BQC3, O70246, Q792T2, Q9Z2S6	Gene names	Punc
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

ROBO3_MOUSE
NC score	0.195083 (rank : 908)	θ value	4.92598e-06 (rank : 759)
Query Neighborhood Hits	1580	Target Neighborhood Hits	524	Shared Neighborhood Hits	288
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

PUNC_HUMAN
NC score	0.194793 (rank : 909)	θ value	8.97725e-08 (rank : 636)
Query Neighborhood Hits	1580	Target Neighborhood Hits	449	Shared Neighborhood Hits	248
SwissProt Accessions	Q8IVU1, O95215	Gene names	PUNC
Domain Architecture	No domain graphic available
Description	Putative neuronal cell adhesion molecule precursor.

DSCL1_HUMAN
NC score	0.194085 (rank : 910)	θ value	2.88788e-06 (rank : 741)
Query Neighborhood Hits	1580	Target Neighborhood Hits	589	Shared Neighborhood Hits	306
SwissProt Accessions	Q8TD84, Q76MU9, Q8IZY3, Q8IZY4, Q8WXU7, Q9ULT7	Gene names	DSCAML1, DSCAM2, KIAA1132
Domain Architecture	No domain graphic available
Description	Down syndrome cell adhesion molecule-like protein 1 precursor (Down syndrome cell adhesion molecule 2).

DSCAM_HUMAN
NC score	0.193816 (rank : 911)	θ value	5.44631e-05 (rank : 844)
Query Neighborhood Hits	1580	Target Neighborhood Hits	524	Shared Neighborhood Hits	283
SwissProt Accessions	O60469, O60468	Gene names	DSCAM
Domain Architecture
Description	Down syndrome cell adhesion molecule precursor (CHD2).

MACF4_HUMAN
NC score	0.193787 (rank : 912)	θ value	2.28291e-11 (rank : 466)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1321	Shared Neighborhood Hits	365
SwissProt Accessions	Q96PK2, Q8WXY1	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoform 4.

DCC_HUMAN
NC score	0.193224 (rank : 913)	θ value	7.59969e-07 (rank : 693)
Query Neighborhood Hits	1580	Target Neighborhood Hits	583	Shared Neighborhood Hits	290
SwissProt Accessions	P43146	Gene names	DCC
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC) (Colorectal cancer suppressor).

BOC_MOUSE
NC score	0.193172 (rank : 914)	θ value	1.17247e-07 (rank : 637)
Query Neighborhood Hits	1580	Target Neighborhood Hits	433	Shared Neighborhood Hits	262
SwissProt Accessions	Q6AZB0, Q6KAM5, Q6P5H3, Q7TMJ3, Q8CE73, Q8CE91, Q8R377, Q923W7	Gene names	Boc
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

ARHG8_MOUSE
NC score	0.192760 (rank : 915)	θ value	1.25267e-09 (rank : 536)
Query Neighborhood Hits	1580	Target Neighborhood Hits	79	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
NC score	0.192123 (rank : 916)	θ value	1.9326e-10 (rank : 494)
Query Neighborhood Hits	1580	Target Neighborhood Hits	187	Shared Neighborhood Hits	96
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

BOC_HUMAN
NC score	0.191992 (rank : 917)	θ value	2.61198e-07 (rank : 659)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	273
SwissProt Accessions	Q9BWV1, Q6UXJ5, Q8N2P7, Q8NF26	Gene names	BOC
Domain Architecture	No domain graphic available
Description	Brother of CDO precursor (Protein BOC).

FGRL1_HUMAN
NC score	0.191741 (rank : 918)	θ value	0.0431538 (rank : 1088)
Query Neighborhood Hits	1580	Target Neighborhood Hits	335	Shared Neighborhood Hits	234
SwissProt Accessions	Q8N441, Q6PJN1, Q9BXN7, Q9H4D7	Gene names	FGFRL1, FGFR5, FHFR
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5) (FGFR-like protein) (FGF homologous factor receptor).

RGNEF_MOUSE
NC score	0.191625 (rank : 919)	θ value	4.92598e-06 (rank : 758)
Query Neighborhood Hits	1580	Target Neighborhood Hits	641	Shared Neighborhood Hits	303
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

FGRL1_MOUSE
NC score	0.191403 (rank : 920)	θ value	0.0961366 (rank : 1132)
Query Neighborhood Hits	1580	Target Neighborhood Hits	325	Shared Neighborhood Hits	234
SwissProt Accessions	Q91V87, Q920C2, Q920C3	Gene names	Fgfrl1, Fgfr5
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor-like 1 precursor (FGF receptor-like protein 1) (Fibroblast growth factor receptor 5).

DCC_MOUSE
NC score	0.191376 (rank : 921)	θ value	7.59969e-07 (rank : 694)
Query Neighborhood Hits	1580	Target Neighborhood Hits	896	Shared Neighborhood Hits	330
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

NCAM2_MOUSE
NC score	0.191095 (rank : 922)	θ value	0.000786445 (rank : 945)
Query Neighborhood Hits	1580	Target Neighborhood Hits	472	Shared Neighborhood Hits	274
SwissProt Accessions	O35136, O35962	Gene names	Ncam2, Ocam, Rncam
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2) (RB-8 neural cell adhesion molecule) (R4B12).

NCAM2_HUMAN
NC score	0.190668 (rank : 923)	θ value	0.00228821 (rank : 985)
Query Neighborhood Hits	1580	Target Neighborhood Hits	441	Shared Neighborhood Hits	267
SwissProt Accessions	O15394	Gene names	NCAM2, NCAM21
Domain Architecture
Description	Neural cell adhesion molecule 2 precursor (N-CAM 2).

FGD6_MOUSE
NC score	0.190615 (rank : 924)	θ value	7.09661e-13 (rank : 405)
Query Neighborhood Hits	1580	Target Neighborhood Hits	282	Shared Neighborhood Hits	113
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

SDK1_HUMAN
NC score	0.190391 (rank : 925)	θ value	5.26297e-08 (rank : 626)
Query Neighborhood Hits	1580	Target Neighborhood Hits	511	Shared Neighborhood Hits	283
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

NCA12_HUMAN
NC score	0.188670 (rank : 926)	θ value	1.43324e-05 (rank : 800)
Query Neighborhood Hits	1580	Target Neighborhood Hits	437	Shared Neighborhood Hits	266
SwissProt Accessions	P13592, P13593	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen).

MYOM1_MOUSE
NC score	0.188629 (rank : 927)	θ value	5.44631e-05 (rank : 848)
Query Neighborhood Hits	1580	Target Neighborhood Hits	415	Shared Neighborhood Hits	261
SwissProt Accessions	Q62234	Gene names	Myom1
Domain Architecture
Description	Myomesin-1 (Skelemin).

NCA11_HUMAN
NC score	0.188137 (rank : 928)	θ value	1.43324e-05 (rank : 799)
Query Neighborhood Hits	1580	Target Neighborhood Hits	443	Shared Neighborhood Hits	267
SwissProt Accessions	P13591, Q15829, Q16180	Gene names	NCAM1, NCAM
Domain Architecture
Description	Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM 140) (NCAM-140) (CD56 antigen).

NFASC_HUMAN
NC score	0.187847 (rank : 929)	θ value	7.1131e-05 (rank : 858)
Query Neighborhood Hits	1580	Target Neighborhood Hits	497	Shared Neighborhood Hits	286
SwissProt Accessions	O94856, Q5T2F0, Q5T2F1, Q5T2F2, Q5T2F3, Q5T2F4, Q5T2F5, Q5T2F6, Q5T2F7, Q5T2F9, Q5T2G0, Q5W9F8, Q68DH3, Q6ZQV6, Q7Z3K1, Q96HT1, Q96K50	Gene names	NFASC, KIAA0756
Domain Architecture
Description	Neurofascin precursor.

NFASC_MOUSE
NC score	0.187590 (rank : 930)	θ value	9.29e-05 (rank : 867)
Query Neighborhood Hits	1580	Target Neighborhood Hits	475	Shared Neighborhood Hits	285
SwissProt Accessions	Q810U3	Gene names	Nfasc
Domain Architecture
Description	Neurofascin precursor.

SDK1_MOUSE
NC score	0.187556 (rank : 931)	θ value	1.99992e-07 (rank : 658)
Query Neighborhood Hits	1580	Target Neighborhood Hits	495	Shared Neighborhood Hits	278
SwissProt Accessions	Q3UH53, Q3UFD1, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1	Gene names	Sdk1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

L1CAM_HUMAN
NC score	0.186853 (rank : 932)	θ value	0.000786445 (rank : 943)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	275
SwissProt Accessions	P32004, Q8TA87	Gene names	L1CAM, CAML1, MIC5
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NCA11_MOUSE
NC score	0.186621 (rank : 933)	θ value	7.1131e-05 (rank : 856)
Query Neighborhood Hits	1580	Target Neighborhood Hits	661	Shared Neighborhood Hits	316
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

ARHGA_MOUSE
NC score	0.186588 (rank : 934)	θ value	3.08544e-08 (rank : 611)
Query Neighborhood Hits	1580	Target Neighborhood Hits	125	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

CDON_MOUSE
NC score	0.186396 (rank : 935)	θ value	0.000786445 (rank : 940)
Query Neighborhood Hits	1580	Target Neighborhood Hits	410	Shared Neighborhood Hits	250
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

SPTN5_HUMAN
NC score	0.186058 (rank : 936)	θ value	4.58923e-20 (rank : 204)
Query Neighborhood Hits	1580	Target Neighborhood Hits	674	Shared Neighborhood Hits	273
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

FGD6_HUMAN
NC score	0.185738 (rank : 937)	θ value	6.00763e-12 (rank : 440)
Query Neighborhood Hits	1580	Target Neighborhood Hits	237	Shared Neighborhood Hits	92
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

CDON_HUMAN
NC score	0.185707 (rank : 938)	θ value	0.00020696 (rank : 884)
Query Neighborhood Hits	1580	Target Neighborhood Hits	412	Shared Neighborhood Hits	243
SwissProt Accessions	Q4KMG0, O14631	Gene names	CDON, CDO
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

L1CAM_MOUSE
NC score	0.185565 (rank : 939)	θ value	7.1131e-05 (rank : 852)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	275
SwissProt Accessions	P11627	Gene names	L1cam, Caml1
Domain Architecture
Description	Neural cell adhesion molecule L1 precursor (N-CAM L1) (CD171 antigen).

NCA12_MOUSE
NC score	0.185354 (rank : 940)	θ value	7.1131e-05 (rank : 857)
Query Neighborhood Hits	1580	Target Neighborhood Hits	399	Shared Neighborhood Hits	255
SwissProt Accessions	P13594, Q61950	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120).

MYPC1_HUMAN
NC score	0.185336 (rank : 941)	θ value	2.88788e-06 (rank : 745)
Query Neighborhood Hits	1580	Target Neighborhood Hits	303	Shared Neighborhood Hits	219
SwissProt Accessions	Q00872, Q15497	Gene names	MYBPC1, MYBPCS
Domain Architecture
Description	Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform).

MYOM1_HUMAN
NC score	0.185105 (rank : 942)	θ value	1.09739e-05 (rank : 789)
Query Neighborhood Hits	1580	Target Neighborhood Hits	405	Shared Neighborhood Hits	250
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MACF1_HUMAN
NC score	0.184800 (rank : 943)	θ value	1.74796e-11 (rank : 461)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1341	Shared Neighborhood Hits	377
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

SPTB1_MOUSE
NC score	0.184729 (rank : 944)	θ value	3.40345e-15 (rank : 350)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	251
SwissProt Accessions	P15508	Gene names	Sptb, Spnb-1, Spnb1, Sptb1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

SYNE1_HUMAN
NC score	0.184711 (rank : 945)	θ value	1.25267e-09 (rank : 543)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1484	Shared Neighborhood Hits	393
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

MYPC3_MOUSE
NC score	0.184395 (rank : 946)	θ value	0.00035302 (rank : 912)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	229
SwissProt Accessions	O70468, O88997	Gene names	Mybpc3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

CNTN5_HUMAN
NC score	0.184079 (rank : 947)	θ value	0.00035302 (rank : 910)
Query Neighborhood Hits	1580	Target Neighborhood Hits	446	Shared Neighborhood Hits	275
SwissProt Accessions	O94779, O94780	Gene names	CNTN5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2) (hNB-2).

MYPC2_HUMAN
NC score	0.183975 (rank : 948)	θ value	6.43352e-06 (rank : 768)
Query Neighborhood Hits	1580	Target Neighborhood Hits	316	Shared Neighborhood Hits	229
SwissProt Accessions	Q14324	Gene names	MYBPC2, MYBPCF
Domain Architecture
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

SDK2_HUMAN
NC score	0.183840 (rank : 949)	θ value	0.000602161 (rank : 938)
Query Neighborhood Hits	1580	Target Neighborhood Hits	495	Shared Neighborhood Hits	283
SwissProt Accessions	Q58EX2, Q86VY3, Q9NTD2, Q9NVB3, Q9P214	Gene names	SDK2, KIAA1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

SDK2_MOUSE
NC score	0.183627 (rank : 950)	θ value	0.000786445 (rank : 949)
Query Neighborhood Hits	1580	Target Neighborhood Hits	480	Shared Neighborhood Hits	281
SwissProt Accessions	Q6V4S5, Q3TTK1, Q5U5W7, Q6ZPP2	Gene names	Sdk2, Kiaa1514
Domain Architecture	No domain graphic available
Description	Protein sidekick-2 precursor.

CNTN4_HUMAN
NC score	0.183433 (rank : 951)	θ value	2.21117e-06 (rank : 732)
Query Neighborhood Hits	1580	Target Neighborhood Hits	449	Shared Neighborhood Hits	264
SwissProt Accessions	Q8IWV2, Q8IX14, Q8TC35	Gene names	CNTN4
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

SPTB1_HUMAN
NC score	0.183405 (rank : 952)	θ value	2.5182e-18 (rank : 255)
Query Neighborhood Hits	1580	Target Neighborhood Hits	541	Shared Neighborhood Hits	260
SwissProt Accessions	P11277, Q15510, Q15519	Gene names	SPTB, SPTB1
Domain Architecture
Description	Spectrin beta chain, erythrocyte (Beta-I spectrin).

LSAMP_HUMAN
NC score	0.183381 (rank : 953)	θ value	6.43352e-06 (rank : 766)
Query Neighborhood Hits	1580	Target Neighborhood Hits	347	Shared Neighborhood Hits	237
SwissProt Accessions	Q13449, Q8IV49	Gene names	LSAMP, LAMP
Domain Architecture
Description	Limbic system-associated membrane protein precursor (LSAMP).

CNTN4_MOUSE
NC score	0.183371 (rank : 954)	θ value	1.87187e-05 (rank : 805)
Query Neighborhood Hits	1580	Target Neighborhood Hits	445	Shared Neighborhood Hits	263
SwissProt Accessions	Q69Z26, Q8BRT6, Q8CBD3	Gene names	Cntn4, Kiaa3024
Domain Architecture	No domain graphic available
Description	Contactin-4 precursor (Brain-derived immunoglobulin superfamily protein 2) (BIG-2).

MYPC3_HUMAN
NC score	0.182912 (rank : 955)	θ value	0.000121331 (rank : 873)
Query Neighborhood Hits	1580	Target Neighborhood Hits	318	Shared Neighborhood Hits	230
SwissProt Accessions	Q14896, Q16410, Q6R2F7, Q9UE27, Q9UM53	Gene names	MYBPC3
Domain Architecture
Description	Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform).

LSAMP_MOUSE
NC score	0.182633 (rank : 956)	θ value	1.43324e-05 (rank : 797)
Query Neighborhood Hits	1580	Target Neighborhood Hits	344	Shared Neighborhood Hits	237
SwissProt Accessions	Q8BLK3	Gene names	Lsamp
Domain Architecture	No domain graphic available
Description	Limbic system-associated membrane protein precursor (LSAMP).

MYOM2_HUMAN
NC score	0.182261 (rank : 957)	θ value	0.00509761 (rank : 1006)
Query Neighborhood Hits	1580	Target Neighborhood Hits	341	Shared Neighborhood Hits	232
SwissProt Accessions	P54296	Gene names	MYOM2
Domain Architecture
Description	Myomesin-2 (M-protein) (165 kDa titin-associated protein) (165 kDa connectin-associated protein).

CNTN3_HUMAN
NC score	0.182200 (rank : 958)	θ value	0.000121331 (rank : 869)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	272
SwissProt Accessions	Q9P232, Q9H039	Gene names	CNTN3, KIAA1496, PANG
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN2_HUMAN
NC score	0.182113 (rank : 959)	θ value	9.29e-05 (rank : 863)
Query Neighborhood Hits	1580	Target Neighborhood Hits	440	Shared Neighborhood Hits	276
SwissProt Accessions	Q02246, P78432	Gene names	CNTN2, TAG1, TAX1
Domain Architecture
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

CNTN2_MOUSE
NC score	0.181752 (rank : 960)	θ value	0.00020696 (rank : 887)
Query Neighborhood Hits	1580	Target Neighborhood Hits	450	Shared Neighborhood Hits	275
SwissProt Accessions	Q61330, Q6NZJ4, Q7TSJ5	Gene names	Cntn2, Tax
Domain Architecture	No domain graphic available
Description	Contactin-2 precursor (Axonin-1) (Axonal glycoprotein TAG-1) (Transient axonal glycoprotein 1) (TAX-1).

NRCAM_MOUSE
NC score	0.181733 (rank : 961)	θ value	0.0148317 (rank : 1051)
Query Neighborhood Hits	1580	Target Neighborhood Hits	432	Shared Neighborhood Hits	268
SwissProt Accessions	Q810U4, Q80U33, Q8BLG8, Q8BX92, Q8BYJ8	Gene names	Nrcam, Kiaa0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (mBravo).

NRCAM_HUMAN
NC score	0.181566 (rank : 962)	θ value	0.00298849 (rank : 992)
Query Neighborhood Hits	1580	Target Neighborhood Hits	439	Shared Neighborhood Hits	268
SwissProt Accessions	Q92823, O15051, O15179, Q9UHI3, Q9UHI4	Gene names	NRCAM, KIAA0343
Domain Architecture
Description	Neuronal cell adhesion molecule precursor (Nr-CAM) (NgCAM-related cell adhesion molecule) (Ng-CAM-related) (hBravo).

BPAEA_HUMAN
NC score	0.181541 (rank : 963)	θ value	7.58209e-15 (rank : 363)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1369	Shared Neighborhood Hits	345
SwissProt Accessions	O94833, Q5TBT0, Q8N1T8, Q8N8J3, Q8WXK9, Q96AK9, Q96DQ5, Q9H555	Gene names	DST, BPAG1, DMH, DT, KIAA0728
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 6/9/10 (Trabeculin-beta) (Bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

MYBPH_HUMAN
NC score	0.181396 (rank : 964)	θ value	3.77169e-06 (rank : 753)
Query Neighborhood Hits	1580	Target Neighborhood Hits	256	Shared Neighborhood Hits	212
SwissProt Accessions	Q13203, Q16886, Q86YC5	Gene names	MYBPH
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

BPA1_MOUSE
NC score	0.181381 (rank : 965)	θ value	2.20605e-14 (rank : 374)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1477	Shared Neighborhood Hits	388
SwissProt Accessions	Q91ZU6, Q91ZU7	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoforms 1/2/3/4 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

CNTN5_MOUSE
NC score	0.180678 (rank : 966)	θ value	0.00175202 (rank : 971)
Query Neighborhood Hits	1580	Target Neighborhood Hits	434	Shared Neighborhood Hits	272
SwissProt Accessions	P68500	Gene names	Cntn5
Domain Architecture	No domain graphic available
Description	Contactin-5 precursor (Neural recognition molecule NB-2).

OPCM_HUMAN
NC score	0.180051 (rank : 967)	θ value	0.000158464 (rank : 880)
Query Neighborhood Hits	1580	Target Neighborhood Hits	332	Shared Neighborhood Hits	234
SwissProt Accessions	Q14982	Gene names	OPCML, OBCAM
Domain Architecture
Description	Opioid-binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML).

CNTN1_MOUSE
NC score	0.179909 (rank : 968)	θ value	0.00020696 (rank : 886)
Query Neighborhood Hits	1580	Target Neighborhood Hits	422	Shared Neighborhood Hits	267
SwissProt Accessions	P12960, Q6NXV7, Q8BR42, Q8C6A0	Gene names	Cntn1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3).

CNTN6_MOUSE
NC score	0.179670 (rank : 969)	θ value	1.43324e-05 (rank : 795)
Query Neighborhood Hits	1580	Target Neighborhood Hits	429	Shared Neighborhood Hits	263
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CNTN6_HUMAN
NC score	0.179552 (rank : 970)	θ value	1.43324e-05 (rank : 794)
Query Neighborhood Hits	1580	Target Neighborhood Hits	422	Shared Neighborhood Hits	265
SwissProt Accessions	Q9UQ52	Gene names	CNTN6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (hNB-3).

MACF1_MOUSE
NC score	0.179496 (rank : 971)	θ value	1.9326e-10 (rank : 495)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1313	Shared Neighborhood Hits	367
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

MYPC2_MOUSE
NC score	0.179487 (rank : 972)	θ value	7.1131e-05 (rank : 855)
Query Neighborhood Hits	1580	Target Neighborhood Hits	297	Shared Neighborhood Hits	218
SwissProt Accessions	Q5XKE0, Q8C109, Q8K2V0	Gene names	Mybpc2
Domain Architecture	No domain graphic available
Description	Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform).

CNTN3_MOUSE
NC score	0.179356 (rank : 973)	θ value	0.000461057 (rank : 922)
Query Neighborhood Hits	1580	Target Neighborhood Hits	447	Shared Neighborhood Hits	265
SwissProt Accessions	Q07409	Gene names	Cntn3, Pang, Pcs
Domain Architecture	No domain graphic available
Description	Contactin-3 precursor (Brain-derived immunoglobulin superfamily protein 1) (BIG-1) (Plasmacytoma-associated neuronal glycoprotein).

CNTN1_HUMAN
NC score	0.179349 (rank : 974)	θ value	0.000270298 (rank : 898)
Query Neighborhood Hits	1580	Target Neighborhood Hits	431	Shared Neighborhood Hits	266
SwissProt Accessions	Q12860, Q12861, Q14030, Q8N466	Gene names	CNTN1
Domain Architecture
Description	Contactin-1 precursor (Neural cell surface protein F3) (Glycoprotein gp135).

MYBPH_MOUSE
NC score	0.178622 (rank : 975)	θ value	6.43352e-06 (rank : 767)
Query Neighborhood Hits	1580	Target Neighborhood Hits	290	Shared Neighborhood Hits	213
SwissProt Accessions	P70402	Gene names	Mybph
Domain Architecture
Description	Myosin-binding protein H (MyBP-H) (H-protein).

DMD_MOUSE
NC score	0.178576 (rank : 976)	θ value	1.25267e-09 (rank : 537)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1111	Shared Neighborhood Hits	339
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

CHL1_MOUSE
NC score	0.178349 (rank : 977)	θ value	9.29e-05 (rank : 862)
Query Neighborhood Hits	1580	Target Neighborhood Hits	402	Shared Neighborhood Hits	260
SwissProt Accessions	P70232, Q8BS24, Q8C6W0, Q8C823, Q8VBY7	Gene names	Chl1, Call
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Cell adhesion molecule with homology to L1CAM) (Close homolog of L1) (Chl1-like protein).

CHL1_HUMAN
NC score	0.176991 (rank : 978)	θ value	0.0113563 (rank : 1035)
Query Neighborhood Hits	1580	Target Neighborhood Hits	413	Shared Neighborhood Hits	258
SwissProt Accessions	O00533, Q2M3G2, Q59FY0	Gene names	CHL1, CALL
Domain Architecture	No domain graphic available
Description	Neural cell adhesion molecule L1-like protein precursor (Close homolog of L1).

ARHGG_HUMAN
NC score	0.175179 (rank : 979)	θ value	2.88788e-06 (rank : 740)
Query Neighborhood Hits	1580	Target Neighborhood Hits	129	Shared Neighborhood Hits	88
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SYNE2_HUMAN
NC score	0.174221 (rank : 980)	θ value	1.09739e-05 (rank : 791)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1323	Shared Neighborhood Hits	359
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

NEGR1_HUMAN
NC score	0.174213 (rank : 981)	θ value	0.00134147 (rank : 966)
Query Neighborhood Hits	1580	Target Neighborhood Hits	346	Shared Neighborhood Hits	237
SwissProt Accessions	Q7Z3B1, Q5VT21, Q6UY06, Q8NAQ3	Gene names	NEGR1
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor.

NTRI_MOUSE
NC score	0.174098 (rank : 982)	θ value	0.000461057 (rank : 926)
Query Neighborhood Hits	1580	Target Neighborhood Hits	342	Shared Neighborhood Hits	239
SwissProt Accessions	Q99PJ0	Gene names	Nt, Hnt
Domain Architecture
Description	Neurotrimin precursor.

DMD_HUMAN
NC score	0.173674 (rank : 983)	θ value	1.17247e-07 (rank : 639)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1135	Shared Neighborhood Hits	342
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

NTRI_HUMAN
NC score	0.173585 (rank : 984)	θ value	0.000461057 (rank : 925)
Query Neighborhood Hits	1580	Target Neighborhood Hits	344	Shared Neighborhood Hits	238
SwissProt Accessions	Q9P121, Q6UXJ3, Q86VJ9	Gene names	NT
Domain Architecture
Description	Neurotrimin precursor (hNT).

SPTN4_HUMAN
NC score	0.173096 (rank : 985)	θ value	1.47631e-18 (rank : 246)
Query Neighborhood Hits	1580	Target Neighborhood Hits	570	Shared Neighborhood Hits	252
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

NEGR1_MOUSE
NC score	0.172781 (rank : 986)	θ value	0.00665767 (rank : 1019)
Query Neighborhood Hits	1580	Target Neighborhood Hits	349	Shared Neighborhood Hits	237
SwissProt Accessions	Q80Z24, Q3UHQ8, Q80T70	Gene names	Negr1, Kiaa3001, Ntra
Domain Architecture	No domain graphic available
Description	Neuronal growth regulator 1 precursor (Kilon protein) (Kindred of IgLON) (Neurotractin).

MAMC1_HUMAN
NC score	0.171060 (rank : 987)	θ value	8.40245e-06 (rank : 773)
Query Neighborhood Hits	1580	Target Neighborhood Hits	357	Shared Neighborhood Hits	234
SwissProt Accessions	Q7Z553	Gene names	MAMDC1, MDGA2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

MAMC1_MOUSE
NC score	0.170572 (rank : 988)	θ value	1.09739e-05 (rank : 787)
Query Neighborhood Hits	1580	Target Neighborhood Hits	357	Shared Neighborhood Hits	232
SwissProt Accessions	P60755	Gene names	Mamdc1, Mdga2
Domain Architecture
Description	MAM domain-containing protein 1 precursor (MAM domain-containing glycosylphosphatidylinositol anchor protein 2).

ARHG5_HUMAN
NC score	0.170379 (rank : 989)	θ value	0.000602161 (rank : 930)
Query Neighborhood Hits	1580	Target Neighborhood Hits	172	Shared Neighborhood Hits	96
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

SPTN2_HUMAN
NC score	0.169950 (rank : 990)	θ value	1.133e-10 (rank : 489)
Query Neighborhood Hits	1580	Target Neighborhood Hits	535	Shared Neighborhood Hits	237
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

PXK_MOUSE
NC score	0.168466 (rank : 991)	θ value	θ > 10 (rank : 2041)
Query Neighborhood Hits	1580	Target Neighborhood Hits	320	Shared Neighborhood Hits	207
SwissProt Accessions	Q8BX57, Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q91WB6	Gene names	Pxk
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

ROBO4_MOUSE
NC score	0.167970 (rank : 992)	θ value	0.0431538 (rank : 1095)
Query Neighborhood Hits	1580	Target Neighborhood Hits	358	Shared Neighborhood Hits	234
SwissProt Accessions	Q8C310, Q9DBW1	Gene names	Robo4
Domain Architecture
Description	Roundabout homolog 4 precursor.

NPTN_MOUSE
NC score	0.167442 (rank : 993)	θ value	0.00035302 (rank : 913)
Query Neighborhood Hits	1580	Target Neighborhood Hits	216	Shared Neighborhood Hits	190
SwissProt Accessions	P97300, Q3U519, Q8C637, Q8C6H8	Gene names	Nptn, Sdfr1, Sdr1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

ARHGG_MOUSE
NC score	0.167202 (rank : 994)	θ value	0.00228821 (rank : 978)
Query Neighborhood Hits	1580	Target Neighborhood Hits	152	Shared Neighborhood Hits	84
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

UTRO_HUMAN
NC score	0.167020 (rank : 995)	θ value	2.21117e-06 (rank : 737)
Query Neighborhood Hits	1580	Target Neighborhood Hits	960	Shared Neighborhood Hits	298
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

NGEF_MOUSE
NC score	0.165722 (rank : 996)	θ value	0.000602161 (rank : 935)
Query Neighborhood Hits	1580	Target Neighborhood Hits	228	Shared Neighborhood Hits	113
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
NC score	0.165153 (rank : 997)	θ value	0.00869519 (rank : 1032)
Query Neighborhood Hits	1580	Target Neighborhood Hits	166	Shared Neighborhood Hits	102
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

PLEC1_HUMAN
NC score	0.164175 (rank : 998)	θ value	0.00035302 (rank : 915)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1326	Shared Neighborhood Hits	351
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

NPTN_HUMAN
NC score	0.162642 (rank : 999)	θ value	0.00390308 (rank : 1001)
Query Neighborhood Hits	1580	Target Neighborhood Hits	212	Shared Neighborhood Hits	188
SwissProt Accessions	Q9Y639, Q59EJ9, Q6NVX7, Q9Y640	Gene names	NPTN, SDFR1, SDR1
Domain Architecture	No domain graphic available
Description	Neuroplastin precursor (Stromal cell-derived receptor 1) (SDR-1).

EEA1_MOUSE
NC score	0.162568 (rank : 1000)	θ value	8.97725e-08 (rank : 632)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1637	Shared Neighborhood Hits	395
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MDGA1_HUMAN
NC score	0.162056 (rank : 1001)	θ value	0.21417 (rank : 1175)
Query Neighborhood Hits	1580	Target Neighborhood Hits	358	Shared Neighborhood Hits	232
SwissProt Accessions	Q8NFP4, Q8NBE3	Gene names	MDGA1, MAMDC3
Domain Architecture
Description	MAM domain-containing glycosylphosphatidylinositol anchor protein 1 precursor (MAM domain-containing protein 3) (GPI and MAM protein) (Glycosylphosphatidylinositol-MAM) (GPIM).

EEA1_HUMAN
NC score	0.161184 (rank : 1002)	θ value	0.000270298 (rank : 899)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1796	Shared Neighborhood Hits	404
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ROBO4_HUMAN
NC score	0.159857 (rank : 1003)	θ value	1.38821 (rank : 1316)
Query Neighborhood Hits	1580	Target Neighborhood Hits	364	Shared Neighborhood Hits	228
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

FSTL4_HUMAN
NC score	0.159828 (rank : 1004)	θ value	0.00298849 (rank : 989)
Query Neighborhood Hits	1580	Target Neighborhood Hits	344	Shared Neighborhood Hits	226
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FGD5_HUMAN
NC score	0.159320 (rank : 1005)	θ value	3.64472e-09 (rank : 563)
Query Neighborhood Hits	1580	Target Neighborhood Hits	235	Shared Neighborhood Hits	76
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

KAZD1_MOUSE
NC score	0.159061 (rank : 1006)	θ value	4.92598e-06 (rank : 757)
Query Neighborhood Hits	1580	Target Neighborhood Hits	281	Shared Neighborhood Hits	188
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

GOGA4_HUMAN
NC score	0.158992 (rank : 1007)	θ value	1.38499e-08 (rank : 597)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2034	Shared Neighborhood Hits	421
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

CF060_HUMAN
NC score	0.158849 (rank : 1008)	θ value	1.87187e-05 (rank : 804)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1270	Shared Neighborhood Hits	370
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

VCAM1_MOUSE
NC score	0.158801 (rank : 1009)	θ value	0.0193708 (rank : 1064)
Query Neighborhood Hits	1580	Target Neighborhood Hits	320	Shared Neighborhood Hits	219
SwissProt Accessions	P29533	Gene names	Vcam1, Vcam-1
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1).

MFA3L_HUMAN
NC score	0.158696 (rank : 1010)	θ value	0.00509761 (rank : 1005)
Query Neighborhood Hits	1580	Target Neighborhood Hits	230	Shared Neighborhood Hits	198
SwissProt Accessions	O75121, Q6TNA8, Q9BVE1, Q9BXK0	Gene names	MFAP3L, KIAA0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor (Protein kinase NYD-SP9).

VCAM1_HUMAN
NC score	0.158412 (rank : 1011)	θ value	0.00509761 (rank : 1010)
Query Neighborhood Hits	1580	Target Neighborhood Hits	352	Shared Neighborhood Hits	218
SwissProt Accessions	P19320, Q6NUP8	Gene names	VCAM1, L1CAM
Domain Architecture
Description	Vascular cell adhesion protein 1 precursor (V-CAM 1) (CD106 antigen) (INCAM-100).

ARHG2_MOUSE
NC score	0.157110 (rank : 1012)	θ value	0.00869519 (rank : 1024)
Query Neighborhood Hits	1580	Target Neighborhood Hits	120	Shared Neighborhood Hits	86
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

FSTL5_HUMAN
NC score	0.157010 (rank : 1013)	θ value	0.0193708 (rank : 1057)
Query Neighborhood Hits	1580	Target Neighborhood Hits	347	Shared Neighborhood Hits	224
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

ARHGB_HUMAN
NC score	0.156885 (rank : 1014)	θ value	0.00298849 (rank : 987)
Query Neighborhood Hits	1580	Target Neighborhood Hits	375	Shared Neighborhood Hits	126
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

CP250_MOUSE
NC score	0.156875 (rank : 1015)	θ value	0.00035302 (rank : 911)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1583	Shared Neighborhood Hits	384
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

TRIPB_HUMAN
NC score	0.156608 (rank : 1016)	θ value	0.00390308 (rank : 1002)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1587	Shared Neighborhood Hits	394
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

GOGB1_HUMAN
NC score	0.156047 (rank : 1017)	θ value	0.00102713 (rank : 954)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2297	Shared Neighborhood Hits	457
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ARHGC_HUMAN
NC score	0.156016 (rank : 1018)	θ value	7.59969e-07 (rank : 689)
Query Neighborhood Hits	1580	Target Neighborhood Hits	351	Shared Neighborhood Hits	128
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

FSTL4_MOUSE
NC score	0.155339 (rank : 1019)	θ value	0.0252991 (rank : 1068)
Query Neighborhood Hits	1580	Target Neighborhood Hits	333	Shared Neighborhood Hits	222
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

MAG_MOUSE
NC score	0.154883 (rank : 1020)	θ value	0.21417 (rank : 1174)
Query Neighborhood Hits	1580	Target Neighborhood Hits	271	Shared Neighborhood Hits	211
SwissProt Accessions	P20917, P16880	Gene names	Mag
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

FGD5_MOUSE
NC score	0.154519 (rank : 1021)	θ value	3.08544e-08 (rank : 613)
Query Neighborhood Hits	1580	Target Neighborhood Hits	170	Shared Neighborhood Hits	71
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

NPHN_HUMAN
NC score	0.154473 (rank : 1022)	θ value	0.813845 (rank : 1263)
Query Neighborhood Hits	1580	Target Neighborhood Hits	362	Shared Neighborhood Hits	226
SwissProt Accessions	O60500	Gene names	NPHS1, NPHN
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

MAG_HUMAN
NC score	0.154151 (rank : 1023)	θ value	0.0736092 (rank : 1120)
Query Neighborhood Hits	1580	Target Neighborhood Hits	278	Shared Neighborhood Hits	212
SwissProt Accessions	P20916	Gene names	MAG
Domain Architecture
Description	Myelin-associated glycoprotein precursor (Siglec-4a).

CP250_HUMAN
NC score	0.154060 (rank : 1024)	θ value	4.1701e-05 (rank : 835)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1805	Shared Neighborhood Hits	396
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

NUMA1_HUMAN
NC score	0.153958 (rank : 1025)	θ value	0.00102713 (rank : 959)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1523	Shared Neighborhood Hits	366
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

GOGA3_MOUSE
NC score	0.153838 (rank : 1026)	θ value	1.09739e-05 (rank : 783)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1437	Shared Neighborhood Hits	377
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

GOGA3_HUMAN
NC score	0.153505 (rank : 1027)	θ value	8.40245e-06 (rank : 772)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1317	Shared Neighborhood Hits	354
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

ARHGC_MOUSE
NC score	0.153172 (rank : 1028)	θ value	3.77169e-06 (rank : 747)
Query Neighborhood Hits	1580	Target Neighborhood Hits	344	Shared Neighborhood Hits	130
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

INVO_HUMAN
NC score	0.153002 (rank : 1029)	θ value	0.00509761 (rank : 1003)
Query Neighborhood Hits	1580	Target Neighborhood Hits	636	Shared Neighborhood Hits	275
SwissProt Accessions	P07476	Gene names	IVL
Domain Architecture	No domain graphic available
Description	Involucrin.

CENPF_HUMAN
NC score	0.152809 (rank : 1030)	θ value	1.17247e-07 (rank : 638)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1932	Shared Neighborhood Hits	413
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

GOGA4_MOUSE
NC score	0.152800 (rank : 1031)	θ value	0.00390308 (rank : 998)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1939	Shared Neighborhood Hits	406
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

BPAEA_MOUSE
NC score	0.152736 (rank : 1032)	θ value	0.0252991 (rank : 1065)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1480	Shared Neighborhood Hits	372
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

FSTL5_MOUSE
NC score	0.152684 (rank : 1033)	θ value	0.125558 (rank : 1142)
Query Neighborhood Hits	1580	Target Neighborhood Hits	355	Shared Neighborhood Hits	221
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

AKAP9_HUMAN
NC score	0.152665 (rank : 1034)	θ value	0.00665767 (rank : 1014)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1710	Shared Neighborhood Hits	396
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

CING_HUMAN
NC score	0.152010 (rank : 1035)	θ value	0.0148317 (rank : 1044)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1275	Shared Neighborhood Hits	354
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

GCC2_MOUSE
NC score	0.151936 (rank : 1036)	θ value	0.00869519 (rank : 1028)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1619	Shared Neighborhood Hits	382
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

CCD46_HUMAN
NC score	0.151771 (rank : 1037)	θ value	0.00035302 (rank : 909)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1430	Shared Neighborhood Hits	366
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

ARHG2_HUMAN
NC score	0.151711 (rank : 1038)	θ value	0.00869519 (rank : 1023)
Query Neighborhood Hits	1580	Target Neighborhood Hits	142	Shared Neighborhood Hits	96
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

CING_MOUSE
NC score	0.150478 (rank : 1039)	θ value	0.0330416 (rank : 1079)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1432	Shared Neighborhood Hits	367
SwissProt Accessions	P59242	Gene names	Cgn
Domain Architecture
Description	Cingulin.

GCC2_HUMAN
NC score	0.150455 (rank : 1040)	θ value	5.26297e-08 (rank : 621)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1558	Shared Neighborhood Hits	372
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

DESP_HUMAN
NC score	0.150440 (rank : 1041)	θ value	0.000158464 (rank : 876)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1470	Shared Neighborhood Hits	383
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

CE152_HUMAN
NC score	0.150271 (rank : 1042)	θ value	0.00020696 (rank : 885)
Query Neighborhood Hits	1580	Target Neighborhood Hits	976	Shared Neighborhood Hits	307
SwissProt Accessions	O94986, Q6NTA0	Gene names	CEP152, KIAA0912
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 152 kDa (Cep152 protein).

RBP24_HUMAN
NC score	0.150132 (rank : 1043)	θ value	5.26297e-08 (rank : 625)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1559	Shared Neighborhood Hits	372
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

KTN1_MOUSE
NC score	0.150091 (rank : 1044)	θ value	0.0330416 (rank : 1081)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1324	Shared Neighborhood Hits	361
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

CE290_HUMAN
NC score	0.150006 (rank : 1045)	θ value	0.000270298 (rank : 897)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1553	Shared Neighborhood Hits	370
SwissProt Accessions	O15078, Q1PSK5, Q66GS8, Q9H2G6, Q9H6Q7, Q9H8I0	Gene names	CEP290, KIAA0373, NPHP6
Domain Architecture	No domain graphic available
Description	Centrosomal protein Cep290 (Nephrocystin-6) (Tumor antigen se2-2).

RAD50_MOUSE
NC score	0.149984 (rank : 1046)	θ value	0.00509761 (rank : 1007)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1366	Shared Neighborhood Hits	358
SwissProt Accessions	P70388, Q6PEB0, Q8C2T7, Q9CU59	Gene names	Rad50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (mRad50).

GOGA2_MOUSE
NC score	0.149956 (rank : 1047)	θ value	1.87187e-05 (rank : 813)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	314
SwissProt Accessions	Q921M4	Gene names	Golga2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130).

ARHGF_HUMAN
NC score	0.149736 (rank : 1048)	θ value	0.0148317 (rank : 1043)
Query Neighborhood Hits	1580	Target Neighborhood Hits	214	Shared Neighborhood Hits	101
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

RAD50_HUMAN
NC score	0.149705 (rank : 1049)	θ value	0.000602161 (rank : 937)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1317	Shared Neighborhood Hits	354
SwissProt Accessions	Q92878, O43254, Q6GMT7, Q6P5X3, Q9UP86	Gene names	RAD50
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD50 (EC 3.6.-.-) (hRAD50).

PIBF1_HUMAN
NC score	0.149494 (rank : 1050)	θ value	0.163984 (rank : 1165)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1041	Shared Neighborhood Hits	336
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

HMMR_MOUSE
NC score	0.149475 (rank : 1051)	θ value	2.44474e-05 (rank : 821)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1178	Shared Neighborhood Hits	345
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

GRAP1_HUMAN
NC score	0.149166 (rank : 1052)	θ value	0.0563607 (rank : 1105)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	317
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

HOOK1_HUMAN
NC score	0.148990 (rank : 1053)	θ value	8.97725e-08 (rank : 635)
Query Neighborhood Hits	1580	Target Neighborhood Hits	942	Shared Neighborhood Hits	318
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

KTN1_HUMAN
NC score	0.148869 (rank : 1054)	θ value	0.0431538 (rank : 1091)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1197	Shared Neighborhood Hits	342
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

HOOK1_MOUSE
NC score	0.148802 (rank : 1055)	θ value	1.53129e-07 (rank : 653)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	317
SwissProt Accessions	Q8BIL5, Q8BIZ2, Q8K0P1, Q8K454, Q9CTN6	Gene names	Hook1
Domain Architecture
Description	Hook homolog 1.

CEP63_HUMAN
NC score	0.148662 (rank : 1056)	θ value	0.0736092 (rank : 1114)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1005	Shared Neighborhood Hits	331
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

TMIGD_HUMAN
NC score	0.148480 (rank : 1057)	θ value	0.813845 (rank : 1269)
Query Neighborhood Hits	1580	Target Neighborhood Hits	240	Shared Neighborhood Hits	189
SwissProt Accessions	Q6UXZ0, Q6ZMC6	Gene names	TMIGD
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

NPHN_MOUSE
NC score	0.148361 (rank : 1058)	θ value	1.06291 (rank : 1288)
Query Neighborhood Hits	1580	Target Neighborhood Hits	370	Shared Neighborhood Hits	225
SwissProt Accessions	Q9QZS7	Gene names	Nphs1, Nphn
Domain Architecture
Description	Nephrin precursor (Renal glomerulus-specific cell adhesion receptor).

NIN_HUMAN
NC score	0.148270 (rank : 1059)	θ value	0.0148317 (rank : 1050)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1416	Shared Neighborhood Hits	361
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

FYCO1_HUMAN
NC score	0.147859 (rank : 1060)	θ value	0.813845 (rank : 1256)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1149	Shared Neighborhood Hits	357
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

SDCG8_HUMAN
NC score	0.147850 (rank : 1061)	θ value	0.0148317 (rank : 1054)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1002	Shared Neighborhood Hits	331
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

FYCO1_MOUSE
NC score	0.147609 (rank : 1062)	θ value	0.0563607 (rank : 1104)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1059	Shared Neighborhood Hits	334
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

FARP2_MOUSE
NC score	0.147592 (rank : 1063)	θ value	4.16044e-13 (rank : 401)
Query Neighborhood Hits	1580	Target Neighborhood Hits	209	Shared Neighborhood Hits	96
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

REST_MOUSE
NC score	0.147549 (rank : 1064)	θ value	1.29631e-06 (rank : 720)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1506	Shared Neighborhood Hits	364
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

TMIGD_MOUSE
NC score	0.147331 (rank : 1065)	θ value	2.36792 (rank : 1372)
Query Neighborhood Hits	1580	Target Neighborhood Hits	234	Shared Neighborhood Hits	189
SwissProt Accessions	Q9D7L8, Q8R202	Gene names	Tmigd
Domain Architecture	No domain graphic available
Description	Transmembrane and immunoglobulin domain-containing protein precursor.

ARHG1_HUMAN
NC score	0.147053 (rank : 1066)	θ value	0.163984 (rank : 1153)
Query Neighborhood Hits	1580	Target Neighborhood Hits	176	Shared Neighborhood Hits	83
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

LBC_HUMAN
NC score	0.147005 (rank : 1067)	θ value	0.00228821 (rank : 984)
Query Neighborhood Hits	1580	Target Neighborhood Hits	90	Shared Neighborhood Hits	70
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

GOGA1_HUMAN
NC score	0.146827 (rank : 1068)	θ value	0.00665767 (rank : 1015)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1222	Shared Neighborhood Hits	354
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

CCD46_MOUSE
NC score	0.146799 (rank : 1069)	θ value	0.00228821 (rank : 980)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1405	Shared Neighborhood Hits	356
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

LRIG1_HUMAN
NC score	0.146573 (rank : 1070)	θ value	5.81887e-07 (rank : 682)
Query Neighborhood Hits	1580	Target Neighborhood Hits	654	Shared Neighborhood Hits	257
SwissProt Accessions	Q96JA1, Q6IQ51, Q96CF9, Q9BYB8, Q9UFI4	Gene names	LRIG1, LIG1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

LRIG2_HUMAN
NC score	0.146493 (rank : 1071)	θ value	7.59969e-07 (rank : 697)
Query Neighborhood Hits	1580	Target Neighborhood Hits	595	Shared Neighborhood Hits	250
SwissProt Accessions	O94898, Q9NSN2	Gene names	LRIG2, KIAA0806, LIG2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor (LIG-2).

CYTSA_MOUSE
NC score	0.146064 (rank : 1072)	θ value	0.00390308 (rank : 997)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1104	Shared Neighborhood Hits	346
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

HMMR_HUMAN
NC score	0.145944 (rank : 1073)	θ value	0.279714 (rank : 1189)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1082	Shared Neighborhood Hits	329
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

PCNT_HUMAN
NC score	0.145871 (rank : 1074)	θ value	0.0113563 (rank : 1038)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1551	Shared Neighborhood Hits	389
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

GRAP1_MOUSE
NC score	0.145819 (rank : 1075)	θ value	0.0330416 (rank : 1080)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1234	Shared Neighborhood Hits	350
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

CYTSA_HUMAN
NC score	0.145728 (rank : 1076)	θ value	0.0148317 (rank : 1045)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1138	Shared Neighborhood Hits	348
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CJ118_MOUSE
NC score	0.145496 (rank : 1077)	θ value	0.00298849 (rank : 988)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1132	Shared Neighborhood Hits	331
SwissProt Accessions	Q8C9S4, Q6P3D6, Q8CJC0	Gene names	Otg1
Domain Architecture	No domain graphic available
Description	Protein C10orf118 homolog (Oocyte-testis gene 1 protein).

LRIG2_MOUSE
NC score	0.145254 (rank : 1078)	θ value	1.29631e-06 (rank : 718)
Query Neighborhood Hits	1580	Target Neighborhood Hits	586	Shared Neighborhood Hits	247
SwissProt Accessions	Q52KR2, Q69ZY8	Gene names	Lrig2, Kiaa0806
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 2 precursor.

K0555_HUMAN
NC score	0.145251 (rank : 1079)	θ value	5.27518 (rank : 1457)
Query Neighborhood Hits	1580	Target Neighborhood Hits	880	Shared Neighborhood Hits	316
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

PCNT_MOUSE
NC score	0.145089 (rank : 1080)	θ value	0.0148317 (rank : 1053)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1207	Shared Neighborhood Hits	338
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

MY18A_HUMAN
NC score	0.144827 (rank : 1081)	θ value	0.0431538 (rank : 1093)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1929	Shared Neighborhood Hits	412
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

CI093_HUMAN
NC score	0.144751 (rank : 1082)	θ value	4.03905 (rank : 1424)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1088	Shared Neighborhood Hits	345
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

MD1L1_HUMAN
NC score	0.144721 (rank : 1083)	θ value	0.125558 (rank : 1149)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	313
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

RB6I2_HUMAN
NC score	0.144672 (rank : 1084)	θ value	0.0431538 (rank : 1094)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1584	Shared Neighborhood Hits	377
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

PEPL_HUMAN
NC score	0.144605 (rank : 1085)	θ value	θ > 10 (rank : 2001)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1141	Shared Neighborhood Hits	337
SwissProt Accessions	O60437, O60314, O60454	Gene names	PPL, KIAA0568
Domain Architecture
Description	Periplakin (195 kDa cornified envelope precursor protein) (190 kDa paraneoplastic pemphigus antigen).

CP135_MOUSE
NC score	0.144331 (rank : 1086)	θ value	0.0431538 (rank : 1085)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1278	Shared Neighborhood Hits	351
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

TRHY_HUMAN
NC score	0.144214 (rank : 1087)	θ value	1.81305 (rank : 1344)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1385	Shared Neighborhood Hits	342
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

RB6I2_MOUSE
NC score	0.144150 (rank : 1088)	θ value	0.00175202 (rank : 974)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1433	Shared Neighborhood Hits	359
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

PEPL_MOUSE
NC score	0.144055 (rank : 1089)	θ value	θ > 10 (rank : 2002)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1105	Shared Neighborhood Hits	336
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

LRIG1_MOUSE
NC score	0.143967 (rank : 1090)	θ value	3.77169e-06 (rank : 751)
Query Neighborhood Hits	1580	Target Neighborhood Hits	627	Shared Neighborhood Hits	254
SwissProt Accessions	P70193	Gene names	Lrig1
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor (LIG-1).

GOGA1_MOUSE
NC score	0.143914 (rank : 1091)	θ value	0.0961366 (rank : 1133)
Query Neighborhood Hits	1580	Target Neighborhood Hits	994	Shared Neighborhood Hits	336
SwissProt Accessions	Q9CW79, Q80YB0	Gene names	Golga1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

MD1L1_MOUSE
NC score	0.143902 (rank : 1092)	θ value	0.163984 (rank : 1162)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1001	Shared Neighborhood Hits	327
SwissProt Accessions	Q9WTX8, Q9WTX9	Gene names	Mad1l1, Mad1
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1).

RAGE_HUMAN
NC score	0.143771 (rank : 1093)	θ value	3.0926 (rank : 1403)
Query Neighborhood Hits	1580	Target Neighborhood Hits	269	Shared Neighborhood Hits	201
SwissProt Accessions	Q15109, Q15279, Q9H2X7, Q9Y3R3	Gene names	AGER, RAGE
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

RN5A_HUMAN
NC score	0.143516 (rank : 1094)	θ value	0.0563607 (rank : 1108)
Query Neighborhood Hits	1580	Target Neighborhood Hits	608	Shared Neighborhood Hits	331
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

CCD39_MOUSE
NC score	0.143144 (rank : 1095)	θ value	1.38821 (rank : 1301)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1026	Shared Neighborhood Hits	327
SwissProt Accessions	Q9D5Y1, Q8CDG6	Gene names	Ccdc39, D3Ertd789e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

STAC_MOUSE
NC score	0.142871 (rank : 1096)	θ value	θ > 10 (rank : 2124)
Query Neighborhood Hits	1580	Target Neighborhood Hits	268	Shared Neighborhood Hits	120
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GOGA6_HUMAN
NC score	0.142795 (rank : 1097)	θ value	0.279714 (rank : 1188)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1007	Shared Neighborhood Hits	326
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

FARP2_HUMAN
NC score	0.142602 (rank : 1098)	θ value	6.00763e-12 (rank : 439)
Query Neighborhood Hits	1580	Target Neighborhood Hits	240	Shared Neighborhood Hits	95
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

SN_MOUSE
NC score	0.142356 (rank : 1099)	θ value	0.21417 (rank : 1179)
Query Neighborhood Hits	1580	Target Neighborhood Hits	416	Shared Neighborhood Hits	233
SwissProt Accessions	Q62230, O55216, Q62228, Q62229	Gene names	Sn, Sa
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (Sheep erythrocyte receptor) (SER) (CD169 antigen).

HOOK3_HUMAN
NC score	0.142318 (rank : 1100)	θ value	2.88788e-06 (rank : 742)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1070	Shared Neighborhood Hits	325
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

REST_HUMAN
NC score	0.142207 (rank : 1101)	θ value	0.00665767 (rank : 1020)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1605	Shared Neighborhood Hits	385
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

PRPK_HUMAN
NC score	0.142203 (rank : 1102)	θ value	θ > 10 (rank : 2031)
Query Neighborhood Hits	1580	Target Neighborhood Hits	131	Shared Neighborhood Hits	123
SwissProt Accessions	Q96S44, Q3T977, Q5JZ01, Q96FM7, Q9NQE6	Gene names	TP53RK, C20orf64, PRPK
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

CCD41_MOUSE
NC score	0.142196 (rank : 1103)	θ value	9.92553e-07 (rank : 705)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1399	Shared Neighborhood Hits	357
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

KAZD1_HUMAN
NC score	0.142062 (rank : 1104)	θ value	3.19293e-05 (rank : 832)
Query Neighborhood Hits	1580	Target Neighborhood Hits	248	Shared Neighborhood Hits	158
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

CCD41_HUMAN
NC score	0.141983 (rank : 1105)	θ value	0.000786445 (rank : 939)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1139	Shared Neighborhood Hits	335
SwissProt Accessions	Q9Y592	Gene names	CCDC41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41 (NY-REN-58 antigen).

ERC2_MOUSE
NC score	0.141884 (rank : 1106)	θ value	0.00869519 (rank : 1027)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1166	Shared Neighborhood Hits	334
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

HOOK3_MOUSE
NC score	0.141881 (rank : 1107)	θ value	9.92553e-07 (rank : 709)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1007	Shared Neighborhood Hits	317
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

MYH10_HUMAN
NC score	0.141875 (rank : 1108)	θ value	5.81887e-07 (rank : 683)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1620	Shared Neighborhood Hits	387
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
NC score	0.141861 (rank : 1109)	θ value	4.45536e-07 (rank : 675)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1612	Shared Neighborhood Hits	383
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

CROCC_HUMAN
NC score	0.141782 (rank : 1110)	θ value	3.0926 (rank : 1383)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1409	Shared Neighborhood Hits	368
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

MY18A_MOUSE
NC score	0.141755 (rank : 1111)	θ value	0.0148317 (rank : 1049)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1989	Shared Neighborhood Hits	420
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

GOGA2_HUMAN
NC score	0.141554 (rank : 1112)	θ value	1.09739e-05 (rank : 782)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	294
SwissProt Accessions	Q08379, Q9BRB0, Q9NYF9	Gene names	GOLGA2
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 2 (Cis-Golgi matrix protein GM130) (Gm130 autoantigen) (Golgin-95).

CROCC_MOUSE
NC score	0.141404 (rank : 1113)	θ value	0.279714 (rank : 1186)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1460	Shared Neighborhood Hits	365
SwissProt Accessions	Q8CJ40, Q7TQL2, Q80U01, Q8R0B9	Gene names	Crocc, Kiaa0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

MYH6_MOUSE
NC score	0.141371 (rank : 1114)	θ value	1.63604e-09 (rank : 548)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1501	Shared Neighborhood Hits	369
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

CP135_HUMAN
NC score	0.141367 (rank : 1115)	θ value	3.0926 (rank : 1382)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1290	Shared Neighborhood Hits	347
SwissProt Accessions	Q66GS9, O75130, Q9H8H7	Gene names	CEP135, CEP4, KIAA0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

AZI1_HUMAN
NC score	0.141312 (rank : 1116)	θ value	0.163984 (rank : 1154)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1000	Shared Neighborhood Hits	312
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

IFT81_HUMAN
NC score	0.141301 (rank : 1117)	θ value	1.81305 (rank : 1329)
Query Neighborhood Hits	1580	Target Neighborhood Hits	893	Shared Neighborhood Hits	323
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

RBCC1_MOUSE
NC score	0.141290 (rank : 1118)	θ value	0.000158464 (rank : 881)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1048	Shared Neighborhood Hits	335
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

TPR_HUMAN
NC score	0.141193 (rank : 1119)	θ value	6.88961 (rank : 1517)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1921	Shared Neighborhood Hits	413
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

MYH7_HUMAN
NC score	0.141097 (rank : 1120)	θ value	2.36244e-08 (rank : 609)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1559	Shared Neighborhood Hits	365
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

RBCC1_HUMAN
NC score	0.140981 (rank : 1121)	θ value	0.365318 (rank : 1213)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1023	Shared Neighborhood Hits	330
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

MYH1_HUMAN
NC score	0.140876 (rank : 1122)	θ value	2.44474e-05 (rank : 825)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1478	Shared Neighborhood Hits	365
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH11_HUMAN
NC score	0.140508 (rank : 1123)	θ value	9.92553e-07 (rank : 713)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1806	Shared Neighborhood Hits	400
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
NC score	0.140323 (rank : 1124)	θ value	9.29e-05 (rank : 866)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1777	Shared Neighborhood Hits	394
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH8_HUMAN
NC score	0.140127 (rank : 1125)	θ value	2.44474e-05 (rank : 827)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1610	Shared Neighborhood Hits	378
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

FLIP1_HUMAN
NC score	0.140095 (rank : 1126)	θ value	0.0563607 (rank : 1103)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1405	Shared Neighborhood Hits	360
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

MYH1_MOUSE
NC score	0.139968 (rank : 1127)	θ value	0.000270298 (rank : 904)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1461	Shared Neighborhood Hits	361
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

ARHG1_MOUSE
NC score	0.139827 (rank : 1128)	θ value	0.0148317 (rank : 1042)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	93
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

MYH13_HUMAN
NC score	0.139770 (rank : 1129)	θ value	1.17247e-07 (rank : 644)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1504	Shared Neighborhood Hits	359
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH2_HUMAN
NC score	0.139526 (rank : 1130)	θ value	0.000602161 (rank : 934)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1491	Shared Neighborhood Hits	368
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

SN_HUMAN
NC score	0.139521 (rank : 1131)	θ value	0.365318 (rank : 1216)
Query Neighborhood Hits	1580	Target Neighborhood Hits	434	Shared Neighborhood Hits	228
SwissProt Accessions	Q9BZZ2, Q96DL4, Q9GZS5, Q9H1H6, Q9H1H7, Q9H7L7	Gene names	SN
Domain Architecture
Description	Sialoadhesin precursor (Sialic acid-binding Ig-like lectin-1) (Siglec- 1) (CD169 antigen).

MYH8_MOUSE
NC score	0.139504 (rank : 1132)	θ value	1.09739e-05 (rank : 788)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1600	Shared Neighborhood Hits	371
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH3_HUMAN
NC score	0.139446 (rank : 1133)	θ value	2.61198e-07 (rank : 662)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1660	Shared Neighborhood Hits	374
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

ICAM5_MOUSE
NC score	0.138938 (rank : 1134)	θ value	0.0252991 (rank : 1069)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	211
SwissProt Accessions	Q60625	Gene names	Icam5, Tlcn
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

STAC_HUMAN
NC score	0.138804 (rank : 1135)	θ value	θ > 10 (rank : 2123)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	126
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

MYH4_HUMAN
NC score	0.138429 (rank : 1136)	θ value	3.41135e-07 (rank : 670)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1377	Shared Neighborhood Hits	349
SwissProt Accessions	Q9Y623	Gene names	MYH4
Domain Architecture
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal) (Myosin heavy chain IIb) (MyHC-IIb).

LU_HUMAN
NC score	0.138426 (rank : 1137)	θ value	θ > 10 (rank : 1899)
Query Neighborhood Hits	1580	Target Neighborhood Hits	283	Shared Neighborhood Hits	206
SwissProt Accessions	P50895, Q86VC7	Gene names	BCAM, LU, MSK19
Domain Architecture
Description	Lutheran blood group glycoprotein precursor (B-CAM cell surface glycoprotein) (Auberger B antigen) (F8/G253 antigen) (CD239 antigen).

ERC2_HUMAN
NC score	0.138417 (rank : 1138)	θ value	1.06291 (rank : 1278)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1156	Shared Neighborhood Hits	327
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

LRIG3_MOUSE
NC score	0.138415 (rank : 1139)	θ value	7.1131e-05 (rank : 853)
Query Neighborhood Hits	1580	Target Neighborhood Hits	611	Shared Neighborhood Hits	255
SwissProt Accessions	Q6P1C6, Q6ZPE6, Q8BRF0, Q8BS51, Q8C5E4	Gene names	Lrig3, Kiaa3016
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor.

MYH14_MOUSE
NC score	0.138403 (rank : 1140)	θ value	0.0113563 (rank : 1037)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1225	Shared Neighborhood Hits	351
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

PRPK_MOUSE
NC score	0.138349 (rank : 1141)	θ value	θ > 10 (rank : 2032)
Query Neighborhood Hits	1580	Target Neighborhood Hits	139	Shared Neighborhood Hits	124
SwissProt Accessions	Q99PW4, Q91W37, Q9CZ32	Gene names	Tp53rk, Prpk, Trp53rk
Domain Architecture
Description	TP53-regulating kinase (EC 2.7.11.1) (p53-related protein kinase) (Nori-2).

MYH6_HUMAN
NC score	0.138109 (rank : 1142)	θ value	2.44474e-05 (rank : 826)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1426	Shared Neighborhood Hits	351
SwissProt Accessions	P13533, Q13943, Q14906, Q14907	Gene names	MYH6, MYHCA
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

FLIP1_MOUSE
NC score	0.138038 (rank : 1143)	θ value	3.0926 (rank : 1389)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1176	Shared Neighborhood Hits	346
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

CN145_HUMAN
NC score	0.138025 (rank : 1144)	θ value	θ > 10 (rank : 1712)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1196	Shared Neighborhood Hits	355
SwissProt Accessions	Q6ZU80, Q96ML4	Gene names	C14orf145
Domain Architecture	No domain graphic available
Description	Protein C14orf145.

MYH9_HUMAN
NC score	0.137662 (rank : 1145)	θ value	0.0563607 (rank : 1107)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1762	Shared Neighborhood Hits	390
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

RABE1_HUMAN
NC score	0.137656 (rank : 1146)	θ value	0.365318 (rank : 1211)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1104	Shared Neighborhood Hits	330
SwissProt Accessions	Q15276, O95369, Q8IVX3	Gene names	RABEP1, RABPT5, RABPT5A
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha) (Rabaptin-4) (NY-REN-17 antigen).

LRIG3_HUMAN
NC score	0.137620 (rank : 1147)	θ value	5.44631e-05 (rank : 847)
Query Neighborhood Hits	1580	Target Neighborhood Hits	601	Shared Neighborhood Hits	253
SwissProt Accessions	Q6UXM1, Q6UXL7, Q8NC72	Gene names	LRIG3, LIG3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats and immunoglobulin-like domains protein 3 precursor (LIG-3).

IFT81_MOUSE
NC score	0.137618 (rank : 1148)	θ value	0.62314 (rank : 1238)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	318
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

MYH4_MOUSE
NC score	0.137490 (rank : 1149)	θ value	0.000270298 (rank : 905)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1476	Shared Neighborhood Hits	361
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

NIN_MOUSE
NC score	0.137482 (rank : 1150)	θ value	1.06291 (rank : 1287)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1376	Shared Neighborhood Hits	350
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

IBP7_HUMAN
NC score	0.137066 (rank : 1151)	θ value	0.00228821 (rank : 983)
Query Neighborhood Hits	1580	Target Neighborhood Hits	220	Shared Neighborhood Hits	159
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

CI039_HUMAN
NC score	0.137042 (rank : 1152)	θ value	1.38821 (rank : 1302)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1171	Shared Neighborhood Hits	335
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

SYCP1_MOUSE
NC score	0.137019 (rank : 1153)	θ value	0.0252991 (rank : 1075)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1456	Shared Neighborhood Hits	370
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

JAM3_MOUSE
NC score	0.136860 (rank : 1154)	θ value	0.365318 (rank : 1208)
Query Neighborhood Hits	1580	Target Neighborhood Hits	286	Shared Neighborhood Hits	197
SwissProt Accessions	Q9D8B7, Q8BT59, Q9D1M9, Q9EPK4	Gene names	Jam3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

EVPL_HUMAN
NC score	0.136741 (rank : 1155)	θ value	8.99809 (rank : 1538)
Query Neighborhood Hits	1580	Target Neighborhood Hits	895	Shared Neighborhood Hits	312
SwissProt Accessions	Q92817	Gene names	EVPL
Domain Architecture
Description	Envoplakin (210 kDa paraneoplastic pemphigus antigen) (p210) (210 kDa cornified envelope precursor protein).

MYH9_MOUSE
NC score	0.136659 (rank : 1156)	θ value	0.279714 (rank : 1195)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1829	Shared Neighborhood Hits	397
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SDCG8_MOUSE
NC score	0.136489 (rank : 1157)	θ value	0.0431538 (rank : 1098)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	304
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

MFA3L_MOUSE
NC score	0.136441 (rank : 1158)	θ value	0.21417 (rank : 1176)
Query Neighborhood Hits	1580	Target Neighborhood Hits	214	Shared Neighborhood Hits	183
SwissProt Accessions	Q9D3X9, Q80TV6, Q8BJA9	Gene names	Mfap3l, Kiaa0626
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 3-like precursor.

CJ118_HUMAN
NC score	0.136418 (rank : 1159)	θ value	0.0736092 (rank : 1116)
Query Neighborhood Hits	1580	Target Neighborhood Hits	937	Shared Neighborhood Hits	316
SwissProt Accessions	Q7Z3E2, Q2M2V6, Q6NS91, Q7RTP1, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3	Gene names	C10orf118
Domain Architecture	No domain graphic available
Description	Protein C10orf118 (CTCL tumor antigen HD-CL-01/L14-2).

TMF1_HUMAN
NC score	0.136193 (rank : 1160)	θ value	0.365318 (rank : 1219)
Query Neighborhood Hits	1580	Target Neighborhood Hits	987	Shared Neighborhood Hits	309
SwissProt Accessions	P82094	Gene names	TMF1
Domain Architecture	No domain graphic available
Description	TATA element modulatory factor (TMF).

RABE1_MOUSE
NC score	0.135874 (rank : 1161)	θ value	0.365318 (rank : 1212)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1105	Shared Neighborhood Hits	338
SwissProt Accessions	O35551, Q99L08, Q9CRP3, Q9EQF9, Q9JI94	Gene names	Rabep1, Rab5ep, Rabpt5, Rabpt5a
Domain Architecture
Description	Rab GTPase-binding effector protein 1 (Rabaptin-5) (Rabaptin-5alpha).

PTPRD_MOUSE
NC score	0.135863 (rank : 1162)	θ value	0.00035302 (rank : 917)
Query Neighborhood Hits	1580	Target Neighborhood Hits	491	Shared Neighborhood Hits	263
SwissProt Accessions	Q64487, Q64486, Q64488, Q64495	Gene names	Ptprd
Domain Architecture	No domain graphic available
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

CCD39_HUMAN
NC score	0.135802 (rank : 1163)	θ value	θ > 10 (rank : 1655)
Query Neighborhood Hits	1580	Target Neighborhood Hits	868	Shared Neighborhood Hits	304
SwissProt Accessions	Q9UFE4	Gene names	CCDC39
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 39.

JAM3_HUMAN
NC score	0.135772 (rank : 1164)	θ value	2.36792 (rank : 1358)
Query Neighborhood Hits	1580	Target Neighborhood Hits	271	Shared Neighborhood Hits	199
SwissProt Accessions	Q9BX67, Q8WWL8, Q96FL1	Gene names	JAM3
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule C precursor (JAM-C) (Junctional adhesion molecule 3) (JAM-3) (JAM-2).

PTPRF_HUMAN
NC score	0.135127 (rank : 1165)	θ value	0.000602161 (rank : 936)
Query Neighborhood Hits	1580	Target Neighborhood Hits	489	Shared Neighborhood Hits	265
SwissProt Accessions	P10586	Gene names	PTPRF, LAR
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase F precursor (EC 3.1.3.48) (LAR protein) (Leukocyte antigen related).

EVPL_MOUSE
NC score	0.135112 (rank : 1166)	θ value	4.03905 (rank : 1427)
Query Neighborhood Hits	1580	Target Neighborhood Hits	952	Shared Neighborhood Hits	304
SwissProt Accessions	Q9D952	Gene names	Evpl
Domain Architecture
Description	Envoplakin (p210) (210 kDa cornified envelope precursor protein).

SYCP1_HUMAN
NC score	0.134983 (rank : 1167)	θ value	θ > 10 (rank : 2138)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1313	Shared Neighborhood Hits	354
SwissProt Accessions	Q15431, O14963	Gene names	SYCP1, SCP1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

AZI1_MOUSE
NC score	0.134792 (rank : 1168)	θ value	1.38821 (rank : 1298)
Query Neighborhood Hits	1580	Target Neighborhood Hits	990	Shared Neighborhood Hits	321
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

GOGA5_HUMAN
NC score	0.134763 (rank : 1169)	θ value	0.00175202 (rank : 972)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1168	Shared Neighborhood Hits	336
SwissProt Accessions	Q8TBA6, O95287, Q03962, Q9UQQ7	Gene names	GOLGA5, RETII, RFG5
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (RET-fused gene 5 protein) (Ret-II protein).

BASI_MOUSE
NC score	0.134645 (rank : 1170)	θ value	0.0961366 (rank : 1129)
Query Neighborhood Hits	1580	Target Neighborhood Hits	238	Shared Neighborhood Hits	183
SwissProt Accessions	P18572, Q6LDB0, Q7TSC0	Gene names	Bsg
Domain Architecture
Description	Basigin precursor (Basic immunoglobulin superfamily) (Membrane glycoprotein gp42) (HT7 antigen) (CD147 antigen).

CCD62_HUMAN
NC score	0.134574 (rank : 1171)	θ value	1.06291 (rank : 1273)
Query Neighborhood Hits	1580	Target Neighborhood Hits	631	Shared Neighborhood Hits	266
SwissProt Accessions	Q6P9F0, Q6ZVF2, Q86VJ0, Q9BYZ5	Gene names	CCDC62
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 60 (Aaa-protein) (Protein TSP- NY).

CK5P2_MOUSE
NC score	0.134362 (rank : 1172)	θ value	0.0252991 (rank : 1066)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1151	Shared Neighborhood Hits	342
SwissProt Accessions	Q8K389, Q6PCN1, Q6ZPL0	Gene names	Cdk5rap2, Kiaa1633
Domain Architecture	No domain graphic available
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48).

IFT74_HUMAN
NC score	0.134201 (rank : 1173)	θ value	θ > 10 (rank : 1827)
Query Neighborhood Hits	1580	Target Neighborhood Hits	949	Shared Neighborhood Hits	313
SwissProt Accessions	Q96LB3, Q6PGQ8, Q9H643, Q9H8G7	Gene names	IFT74, CCDC2, CMG1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

CENPE_HUMAN
NC score	0.134117 (rank : 1174)	θ value	1.09739e-05 (rank : 779)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2060	Shared Neighborhood Hits	427
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CI094_HUMAN
NC score	0.133973 (rank : 1175)	θ value	0.0736092 (rank : 1115)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	200
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

BASI_HUMAN
NC score	0.133968 (rank : 1176)	θ value	0.813845 (rank : 1250)
Query Neighborhood Hits	1580	Target Neighborhood Hits	211	Shared Neighborhood Hits	172
SwissProt Accessions	P35613, Q7Z796, Q8IZL7	Gene names	BSG
Domain Architecture
Description	Basigin precursor (Leukocyte activation antigen M6) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (5F7) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (OK blood group antigen) (CD147 antigen).

CCD11_HUMAN
NC score	0.133868 (rank : 1177)	θ value	θ > 10 (rank : 1648)
Query Neighborhood Hits	1580	Target Neighborhood Hits	822	Shared Neighborhood Hits	295
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

PTPRD_HUMAN
NC score	0.133814 (rank : 1178)	θ value	0.00035302 (rank : 916)
Query Neighborhood Hits	1580	Target Neighborhood Hits	485	Shared Neighborhood Hits	254
SwissProt Accessions	P23468	Gene names	PTPRD
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase delta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase delta) (R-PTP-delta).

IGS4B_MOUSE
NC score	0.133666 (rank : 1179)	θ value	0.000602161 (rank : 932)
Query Neighborhood Hits	1580	Target Neighborhood Hits	328	Shared Neighborhood Hits	204
SwissProt Accessions	Q99N28, Q8BSQ8, Q8K1H8	Gene names	Igsf4b, Necl1, Syncam3, Tsll1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (Necl-1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3).

GOGA5_MOUSE
NC score	0.133659 (rank : 1180)	θ value	0.000158464 (rank : 879)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1434	Shared Neighborhood Hits	358
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

SWP70_HUMAN
NC score	0.133604 (rank : 1181)	θ value	θ > 10 (rank : 2137)
Query Neighborhood Hits	1580	Target Neighborhood Hits	973	Shared Neighborhood Hits	323
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ICAM5_HUMAN
NC score	0.133565 (rank : 1182)	θ value	0.0961366 (rank : 1134)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	205
SwissProt Accessions	Q9UMF0, Q9Y6F3	Gene names	ICAM5, TLCN, TLN
Domain Architecture
Description	Intercellular adhesion molecule 5 precursor (ICAM-5) (Telencephalin).

PTPRS_HUMAN
NC score	0.133380 (rank : 1183)	θ value	0.00020696 (rank : 895)
Query Neighborhood Hits	1580	Target Neighborhood Hits	472	Shared Neighborhood Hits	257
SwissProt Accessions	Q13332, O75255, O75870, Q15718, Q16341	Gene names	PTPRS
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase S precursor (EC 3.1.3.48) (R-PTP-S) (Protein-tyrosine phosphatase sigma) (R-PTP-sigma).

GRAP_HUMAN
NC score	0.133247 (rank : 1184)	θ value	0.47712 (rank : 1225)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	109
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

KIRR2_HUMAN
NC score	0.133043 (rank : 1185)	θ value	θ > 10 (rank : 1868)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	201
SwissProt Accessions	Q6UWL6, Q6P1R1, Q7Z5P1, Q7Z5P2, Q96IQ8, Q9H0T1	Gene names	KIRREL2, NEPH3
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3).

CYLN2_HUMAN
NC score	0.132793 (rank : 1186)	θ value	4.03905 (rank : 1425)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1004	Shared Neighborhood Hits	317
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

STAC3_MOUSE
NC score	0.132717 (rank : 1187)	θ value	θ > 10 (rank : 2122)
Query Neighborhood Hits	1580	Target Neighborhood Hits	232	Shared Neighborhood Hits	109
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

CD22_MOUSE
NC score	0.132341 (rank : 1188)	θ value	0.163984 (rank : 1157)
Query Neighborhood Hits	1580	Target Neighborhood Hits	331	Shared Neighborhood Hits	196
SwissProt Accessions	P35329, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51	Gene names	Cd22, Lyb-8
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

MALT1_HUMAN
NC score	0.132279 (rank : 1189)	θ value	θ > 10 (rank : 1906)
Query Neighborhood Hits	1580	Target Neighborhood Hits	236	Shared Neighborhood Hits	178
SwissProt Accessions	Q9UDY8, Q9NTB7, Q9ULX4	Gene names	MALT1, MLT
Domain Architecture
Description	Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase).

KIRR2_MOUSE
NC score	0.132274 (rank : 1190)	θ value	θ > 10 (rank : 1869)
Query Neighborhood Hits	1580	Target Neighborhood Hits	326	Shared Neighborhood Hits	204
SwissProt Accessions	Q7TSU7, Q7TQ98	Gene names	Kirrel2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 2 precursor (Kin of irregular chiasm-like protein 2).

CYLN2_MOUSE
NC score	0.132251 (rank : 1191)	θ value	θ > 10 (rank : 1741)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1002	Shared Neighborhood Hits	319
SwissProt Accessions	Q9Z0H8, Q7TSI9, Q8CHU1, Q9EP81	Gene names	Cyln2, Kiaa0291
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115).

HMCN1_HUMAN
NC score	0.132146 (rank : 1192)	θ value	1.69304e-06 (rank : 724)
Query Neighborhood Hits	1580	Target Neighborhood Hits	983	Shared Neighborhood Hits	272
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

HOOK2_MOUSE
NC score	0.132068 (rank : 1193)	θ value	θ > 10 (rank : 1819)
Query Neighborhood Hits	1580	Target Neighborhood Hits	736	Shared Neighborhood Hits	294
SwissProt Accessions	Q7TMK6, Q8BY47, Q8R347, Q8VCN4, Q99LU2	Gene names	Hook2
Domain Architecture
Description	Hook homolog 2.

JAM1_HUMAN
NC score	0.131899 (rank : 1194)	θ value	6.88961 (rank : 1491)
Query Neighborhood Hits	1580	Target Neighborhood Hits	294	Shared Neighborhood Hits	204
SwissProt Accessions	Q9Y624	Gene names	F11R, JAM1, JCAM
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (Platelet adhesion molecule 1) (PAM-1) (Platelet F11 receptor) (CD321 antigen).

CCD19_HUMAN
NC score	0.131864 (rank : 1195)	θ value	θ > 10 (rank : 1650)
Query Neighborhood Hits	1580	Target Neighborhood Hits	639	Shared Neighborhood Hits	258
SwissProt Accessions	Q9UL16	Gene names	CCDC19, NESG1
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 19 (Nasopharyngeal epithelium- specific protein 1).

STAC3_HUMAN
NC score	0.131796 (rank : 1196)	θ value	θ > 10 (rank : 2121)
Query Neighborhood Hits	1580	Target Neighborhood Hits	228	Shared Neighborhood Hits	109
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

IFT74_MOUSE
NC score	0.131773 (rank : 1197)	θ value	1.81305 (rank : 1328)
Query Neighborhood Hits	1580	Target Neighborhood Hits	939	Shared Neighborhood Hits	314
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

RAGE_MOUSE
NC score	0.131719 (rank : 1198)	θ value	θ > 10 (rank : 2045)
Query Neighborhood Hits	1580	Target Neighborhood Hits	295	Shared Neighborhood Hits	196
SwissProt Accessions	Q62151	Gene names	Ager, Rage
Domain Architecture
Description	Advanced glycosylation end product-specific receptor precursor (Receptor for advanced glycosylation end products).

GRAP_MOUSE
NC score	0.131712 (rank : 1199)	θ value	4.03905 (rank : 1430)
Query Neighborhood Hits	1580	Target Neighborhood Hits	309	Shared Neighborhood Hits	106
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CD22_HUMAN
NC score	0.131646 (rank : 1200)	θ value	θ > 10 (rank : 1669)
Query Neighborhood Hits	1580	Target Neighborhood Hits	365	Shared Neighborhood Hits	213
SwissProt Accessions	P20273, O95699, O95701, O95702, O95703, Q01665, Q92872, Q92873, Q9UQA6, Q9UQA7, Q9UQA8, Q9UQA9, Q9UQB0, Q9Y2A6	Gene names	CD22
Domain Architecture
Description	B-cell receptor CD22 precursor (Leu-14) (B-lymphocyte cell adhesion molecule) (BL-CAM) (Siglec-2).

MY18B_HUMAN
NC score	0.131424 (rank : 1201)	θ value	θ > 10 (rank : 1931)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1299	Shared Neighborhood Hits	363
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

PGBM_HUMAN
NC score	0.130681 (rank : 1202)	θ value	9.29e-05 (rank : 868)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1113	Shared Neighborhood Hits	285
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

SWP70_MOUSE
NC score	0.130680 (rank : 1203)	θ value	6.88961 (rank : 1516)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1097	Shared Neighborhood Hits	342
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CCHCR_MOUSE
NC score	0.130625 (rank : 1204)	θ value	θ > 10 (rank : 1667)
Query Neighborhood Hits	1580	Target Neighborhood Hits	932	Shared Neighborhood Hits	308
SwissProt Accessions	Q8K2I2	Gene names	Cchcr1, Hcr
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein).

SPAG5_MOUSE
NC score	0.130501 (rank : 1205)	θ value	0.000270298 (rank : 907)
Query Neighborhood Hits	1580	Target Neighborhood Hits	612	Shared Neighborhood Hits	263
SwissProt Accessions	Q7TME2, Q8CH61	Gene names	Spag5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Mastrin) (Mitotic spindle-associated protein p126) (MAP126).

VSIG2_HUMAN
NC score	0.130459 (rank : 1206)	θ value	0.47712 (rank : 1233)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	196
SwissProt Accessions	Q96IQ7, O95791, Q9NX42	Gene names	VSIG2, CTH, CTXL
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

CN145_MOUSE
NC score	0.130359 (rank : 1207)	θ value	θ > 10 (rank : 1713)
Query Neighborhood Hits	1580	Target Neighborhood Hits	916	Shared Neighborhood Hits	304
SwissProt Accessions	Q8BI22	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf145 homolog.

CCHCR_HUMAN
NC score	0.130253 (rank : 1208)	θ value	θ > 10 (rank : 1666)
Query Neighborhood Hits	1580	Target Neighborhood Hits	717	Shared Neighborhood Hits	277
SwissProt Accessions	Q8TD31, Q9NRK8, Q9NWY9, Q9NXJ4, Q9NXK3, Q9Y6W1, Q9Y6W2	Gene names	CCHCR1, C6orf18, HCR
Domain Architecture
Description	Coiled-coil alpha-helical rod protein 1 (Alpha helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8).

OPTN_MOUSE
NC score	0.130058 (rank : 1209)	θ value	0.0252991 (rank : 1072)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1120	Shared Neighborhood Hits	332
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

MYH14_HUMAN
NC score	0.130022 (rank : 1210)	θ value	0.00298849 (rank : 990)
Query Neighborhood Hits	1580	Target Neighborhood Hits	995	Shared Neighborhood Hits	310
SwissProt Accessions	Q7Z406, Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27, Q9BW35, Q9H882	Gene names	MYH14, KIAA2034
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

IBP7_MOUSE
NC score	0.129664 (rank : 1211)	θ value	0.0736092 (rank : 1119)
Query Neighborhood Hits	1580	Target Neighborhood Hits	230	Shared Neighborhood Hits	154
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

KIRR3_HUMAN
NC score	0.129632 (rank : 1212)	θ value	3.0926 (rank : 1392)
Query Neighborhood Hits	1580	Target Neighborhood Hits	302	Shared Neighborhood Hits	194
SwissProt Accessions	Q8IZU9, Q6UWJ9, Q6UWL5, Q96JG0	Gene names	KIRREL3, KIAA1867, NEPH2
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3) (Nephrin-like 2).

PXK_HUMAN
NC score	0.129424 (rank : 1213)	θ value	θ > 10 (rank : 2040)
Query Neighborhood Hits	1580	Target Neighborhood Hits	216	Shared Neighborhood Hits	140
SwissProt Accessions	Q7Z7A4, Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8	Gene names	PXK
Domain Architecture	No domain graphic available
Description	PX domain-containing protein kinase-like protein (Modulator of Na,K- ATPase) (MONaKA).

KIRR3_MOUSE
NC score	0.129414 (rank : 1214)	θ value	3.0926 (rank : 1393)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	190
SwissProt Accessions	Q8BR86, Q6P555, Q810H3, Q8BGQ5, Q8BRS8	Gene names	Kirrel3, Kiaa1867
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 3 precursor (Kin of irregular chiasm-like protein 3).

NCK1_HUMAN
NC score	0.129363 (rank : 1215)	θ value	0.125558 (rank : 1151)
Query Neighborhood Hits	1580	Target Neighborhood Hits	312	Shared Neighborhood Hits	113
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CCD21_MOUSE
NC score	0.129184 (rank : 1216)	θ value	8.99809 (rank : 1526)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1135	Shared Neighborhood Hits	343
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CR034_MOUSE
NC score	0.128680 (rank : 1217)	θ value	8.99809 (rank : 1533)
Query Neighborhood Hits	1580	Target Neighborhood Hits	643	Shared Neighborhood Hits	274
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

FARP1_HUMAN
NC score	0.128501 (rank : 1218)	θ value	3.29651e-10 (rank : 507)
Query Neighborhood Hits	1580	Target Neighborhood Hits	241	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

KIRR1_HUMAN
NC score	0.128333 (rank : 1219)	θ value	0.0148317 (rank : 1047)
Query Neighborhood Hits	1580	Target Neighborhood Hits	401	Shared Neighborhood Hits	203
SwissProt Accessions	Q96J84, Q5XKC6, Q7Z696, Q7Z7N8, Q8TB15, Q9H9N1, Q9NVA5	Gene names	KIRREL, NEPH1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

SMC3_HUMAN
NC score	0.128305 (rank : 1220)	θ value	0.365318 (rank : 1214)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1186	Shared Neighborhood Hits	340
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
NC score	0.128288 (rank : 1221)	θ value	0.365318 (rank : 1215)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1187	Shared Neighborhood Hits	341
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

IGS4B_HUMAN
NC score	0.128285 (rank : 1222)	θ value	0.000602161 (rank : 931)
Query Neighborhood Hits	1580	Target Neighborhood Hits	305	Shared Neighborhood Hits	201
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

RIMB1_MOUSE
NC score	0.128217 (rank : 1223)	θ value	θ > 10 (rank : 2062)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1376	Shared Neighborhood Hits	399
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

KMHN1_HUMAN
NC score	0.128171 (rank : 1224)	θ value	θ > 10 (rank : 1870)
Query Neighborhood Hits	1580	Target Neighborhood Hits	950	Shared Neighborhood Hits	308
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

JAM2_HUMAN
NC score	0.128072 (rank : 1225)	θ value	θ > 10 (rank : 1843)
Query Neighborhood Hits	1580	Target Neighborhood Hits	304	Shared Neighborhood Hits	217
SwissProt Accessions	P57087, Q6UXG6, Q6YNC1	Gene names	JAM2, C21orf43, VEJAM
Domain Architecture
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

SMC1A_MOUSE
NC score	0.127890 (rank : 1226)	θ value	0.62314 (rank : 1245)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1384	Shared Neighborhood Hits	355
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

CASP_HUMAN
NC score	0.127876 (rank : 1227)	θ value	0.163984 (rank : 1156)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1131	Shared Neighborhood Hits	330
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CCD11_MOUSE
NC score	0.127701 (rank : 1228)	θ value	θ > 10 (rank : 1649)
Query Neighborhood Hits	1580	Target Neighborhood Hits	498	Shared Neighborhood Hits	222
SwissProt Accessions	Q9D439	Gene names	Ccdc11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

HOOK2_HUMAN
NC score	0.127685 (rank : 1229)	θ value	θ > 10 (rank : 1818)
Query Neighborhood Hits	1580	Target Neighborhood Hits	714	Shared Neighborhood Hits	277
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

CNTRB_MOUSE
NC score	0.127621 (rank : 1230)	θ value	6.88961 (rank : 1482)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1029	Shared Neighborhood Hits	315
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

CASP_MOUSE
NC score	0.127592 (rank : 1231)	θ value	0.813845 (rank : 1252)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1152	Shared Neighborhood Hits	331
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CALD1_HUMAN
NC score	0.127537 (rank : 1232)	θ value	θ > 10 (rank : 1639)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	294
SwissProt Accessions	Q05682, Q13978, Q13979, Q14741, Q14742	Gene names	CALD1, CAD, CDM
Domain Architecture
Description	Caldesmon (CDM).

LUZP1_MOUSE
NC score	0.127474 (rank : 1233)	θ value	0.00869519 (rank : 1031)
Query Neighborhood Hits	1580	Target Neighborhood Hits	940	Shared Neighborhood Hits	307
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

TSC1_HUMAN
NC score	0.127474 (rank : 1234)	θ value	6.88961 (rank : 1518)
Query Neighborhood Hits	1580	Target Neighborhood Hits	765	Shared Neighborhood Hits	289
SwissProt Accessions	Q92574	Gene names	TSC1, KIAA0243, TSC
Domain Architecture
Description	Hamartin (Tuberous sclerosis 1 protein).

NCK2_HUMAN
NC score	0.127463 (rank : 1235)	θ value	0.163984 (rank : 1163)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	109
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

BRE1A_MOUSE
NC score	0.127406 (rank : 1236)	θ value	0.163984 (rank : 1155)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1025	Shared Neighborhood Hits	297
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CK5P2_HUMAN
NC score	0.127143 (rank : 1237)	θ value	0.21417 (rank : 1169)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1433	Shared Neighborhood Hits	365
SwissProt Accessions	Q96SN8, Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9	Gene names	CDK5RAP2, CEP215, KIAA1633
Domain Architecture
Description	CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215).

TAXB1_MOUSE
NC score	0.127141 (rank : 1238)	θ value	θ > 10 (rank : 2151)
Query Neighborhood Hits	1580	Target Neighborhood Hits	886	Shared Neighborhood Hits	304
SwissProt Accessions	Q3UKC1, Q91YT6, Q9CVF0, Q9DC45	Gene names	Tax1bp1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 homolog.

PGBM_MOUSE
NC score	0.126920 (rank : 1239)	θ value	0.00134147 (rank : 967)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1073	Shared Neighborhood Hits	283
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

KIRR1_MOUSE
NC score	0.126722 (rank : 1240)	θ value	0.0252991 (rank : 1071)
Query Neighborhood Hits	1580	Target Neighborhood Hits	403	Shared Neighborhood Hits	200
SwissProt Accessions	Q80W68, Q8CIJ4, Q8CJ59, Q923L4	Gene names	Kirrel1, Kirrel, Neph1
Domain Architecture	No domain graphic available
Description	Kin of IRRE-like protein 1 precursor (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1).

GAS8_HUMAN
NC score	0.126688 (rank : 1241)	θ value	θ > 10 (rank : 1784)
Query Neighborhood Hits	1580	Target Neighborhood Hits	819	Shared Neighborhood Hits	294
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

CCD13_HUMAN
NC score	0.126536 (rank : 1242)	θ value	4.03905 (rank : 1422)
Query Neighborhood Hits	1580	Target Neighborhood Hits	721	Shared Neighborhood Hits	279
SwissProt Accessions	Q8IYE1	Gene names	CCDC13
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 13.

JAM1_MOUSE
NC score	0.126438 (rank : 1243)	θ value	5.27518 (rank : 1455)
Query Neighborhood Hits	1580	Target Neighborhood Hits	287	Shared Neighborhood Hits	202
SwissProt Accessions	O88792	Gene names	F11r, Jam1, Jcam, Jcam1
Domain Architecture
Description	Junctional adhesion molecule A precursor (JAM-A) (Junctional adhesion molecule 1) (JAM-1) (CD321 antigen).

VSIG2_MOUSE
NC score	0.126328 (rank : 1244)	θ value	0.62314 (rank : 1247)
Query Neighborhood Hits	1580	Target Neighborhood Hits	316	Shared Neighborhood Hits	192
SwissProt Accessions	Q9Z109, Q9CVA4, Q9D0T4	Gene names	Vsig2, Ctm, Ctxl
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 2 precursor (CT- like protein) (Cortical thymocyte-like protein).

LRFN4_HUMAN
NC score	0.126107 (rank : 1245)	θ value	6.43352e-06 (rank : 764)
Query Neighborhood Hits	1580	Target Neighborhood Hits	462	Shared Neighborhood Hits	206
SwissProt Accessions	Q6PJG9, Q9BWJ0	Gene names	LRFN4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

OFD1_HUMAN
NC score	0.125947 (rank : 1246)	θ value	6.88961 (rank : 1501)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	280
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

RUFY2_HUMAN
NC score	0.125761 (rank : 1247)	θ value	3.0926 (rank : 1405)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1208	Shared Neighborhood Hits	342
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY1_HUMAN
NC score	0.125760 (rank : 1248)	θ value	θ > 10 (rank : 2067)
Query Neighborhood Hits	1580	Target Neighborhood Hits	848	Shared Neighborhood Hits	323
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

LRFN2_MOUSE
NC score	0.125735 (rank : 1249)	θ value	2.44474e-05 (rank : 822)
Query Neighborhood Hits	1580	Target Neighborhood Hits	450	Shared Neighborhood Hits	203
SwissProt Accessions	Q80TG9, Q9CYK3	Gene names	Lrfn2, Kiaa1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

SMC1A_HUMAN
NC score	0.125714 (rank : 1250)	θ value	0.279714 (rank : 1200)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1346	Shared Neighborhood Hits	352
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

LRFN4_MOUSE
NC score	0.125645 (rank : 1251)	θ value	6.43352e-06 (rank : 765)
Query Neighborhood Hits	1580	Target Neighborhood Hits	442	Shared Neighborhood Hits	202
SwissProt Accessions	Q80XU8, Q3TQG8, Q8K3C4	Gene names	Lrfn4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor.

LRC45_HUMAN
NC score	0.125414 (rank : 1252)	θ value	θ > 10 (rank : 1893)
Query Neighborhood Hits	1580	Target Neighborhood Hits	933	Shared Neighborhood Hits	319
SwissProt Accessions	Q96CN5	Gene names	LRRC45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

GRB2_HUMAN
NC score	0.125315 (rank : 1253)	θ value	θ > 10 (rank : 1803)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	108
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

LRFN2_HUMAN
NC score	0.125263 (rank : 1254)	θ value	4.1701e-05 (rank : 840)
Query Neighborhood Hits	1580	Target Neighborhood Hits	450	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ULH4, Q5SYP9	Gene names	LRFN2, KIAA1246
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor.

GRB2_MOUSE
NC score	0.125155 (rank : 1255)	θ value	θ > 10 (rank : 1804)
Query Neighborhood Hits	1580	Target Neighborhood Hits	312	Shared Neighborhood Hits	108
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

INCE_HUMAN
NC score	0.124994 (rank : 1256)	θ value	θ > 10 (rank : 1835)
Query Neighborhood Hits	1580	Target Neighborhood Hits	978	Shared Neighborhood Hits	302
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

SM1L2_MOUSE
NC score	0.124847 (rank : 1257)	θ value	0.00175202 (rank : 975)
Query Neighborhood Hits	1580	Target Neighborhood Hits	918	Shared Neighborhood Hits	313
SwissProt Accessions	Q920F6	Gene names	Smc1l2
Domain Architecture
Description	Structural maintenance of chromosomes 1-like 2 protein (SMC1beta protein).

GCC1_HUMAN
NC score	0.124723 (rank : 1258)	θ value	0.163984 (rank : 1160)
Query Neighborhood Hits	1580	Target Neighborhood Hits	887	Shared Neighborhood Hits	302
SwissProt Accessions	Q96CN9, Q9H6N7	Gene names	GCC1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

INCE_MOUSE
NC score	0.124358 (rank : 1259)	θ value	θ > 10 (rank : 1836)
Query Neighborhood Hits	1580	Target Neighborhood Hits	903	Shared Neighborhood Hits	295
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

KMHN1_MOUSE
NC score	0.124010 (rank : 1260)	θ value	θ > 10 (rank : 1871)
Query Neighborhood Hits	1580	Target Neighborhood Hits	949	Shared Neighborhood Hits	310
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

SM1L2_HUMAN
NC score	0.123923 (rank : 1261)	θ value	2.36792 (rank : 1368)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1019	Shared Neighborhood Hits	323
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

NEMO_HUMAN
NC score	0.123879 (rank : 1262)	θ value	0.47712 (rank : 1229)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	309
SwissProt Accessions	Q9Y6K9	Gene names	IKBKG, FIP3, NEMO
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (FIP-3).

SAS6_MOUSE
NC score	0.123684 (rank : 1263)	θ value	2.36792 (rank : 1367)
Query Neighborhood Hits	1580	Target Neighborhood Hits	931	Shared Neighborhood Hits	313
SwissProt Accessions	Q80UK7, Q9CYT4	Gene names	Sass6, Sas6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog.

BRE1A_HUMAN
NC score	0.123614 (rank : 1264)	θ value	1.38821 (rank : 1299)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1071	Shared Neighborhood Hits	298
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

NEMO_MOUSE
NC score	0.123425 (rank : 1265)	θ value	θ > 10 (rank : 1967)
Query Neighborhood Hits	1580	Target Neighborhood Hits	658	Shared Neighborhood Hits	278
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

GRAP2_HUMAN
NC score	0.123109 (rank : 1266)	θ value	4.03905 (rank : 1429)
Query Neighborhood Hits	1580	Target Neighborhood Hits	304	Shared Neighborhood Hits	106
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ACTN4_MOUSE
NC score	0.122863 (rank : 1267)	θ value	0.0193708 (rank : 1055)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	139
SwissProt Accessions	P57780	Gene names	Actn4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

LRFN3_MOUSE
NC score	0.122756 (rank : 1268)	θ value	1.09739e-05 (rank : 786)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	204
SwissProt Accessions	Q8BLY3	Gene names	Lrfn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

CR034_HUMAN
NC score	0.122621 (rank : 1269)	θ value	0.0736092 (rank : 1117)
Query Neighborhood Hits	1580	Target Neighborhood Hits	538	Shared Neighborhood Hits	248
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

LRC45_MOUSE
NC score	0.122576 (rank : 1270)	θ value	θ > 10 (rank : 1894)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	307
SwissProt Accessions	Q8CIM1, Q3U5Z2	Gene names	Lrrc45
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 45.

ZN291_HUMAN
NC score	0.122311 (rank : 1271)	θ value	θ > 10 (rank : 2215)
Query Neighborhood Hits	1580	Target Neighborhood Hits	647	Shared Neighborhood Hits	268
SwissProt Accessions	Q9BY12	Gene names	ZNF291
Domain Architecture
Description	Zinc finger protein 291.

CCD21_HUMAN
NC score	0.122044 (rank : 1272)	θ value	8.99809 (rank : 1525)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1228	Shared Neighborhood Hits	345
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

JAM2_MOUSE
NC score	0.121644 (rank : 1273)	θ value	θ > 10 (rank : 1844)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	207
SwissProt Accessions	Q9JI59, Q8C5K9, Q8CE95	Gene names	Jam2, Vejam
Domain Architecture	No domain graphic available
Description	Junctional adhesion molecule B precursor (JAM-B) (Junctional adhesion molecule 2) (Vascular endothelial junction-associated molecule) (VE- JAM) (CD322 antigen).

TAXB1_HUMAN
NC score	0.121642 (rank : 1274)	θ value	θ > 10 (rank : 2150)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	287
SwissProt Accessions	Q86VP1, O60398, O95770, Q13311, Q9BQG5, Q9UI88	Gene names	TAX1BP1, T6BP
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 1 (TRAF6-binding protein).

GOG8A_HUMAN
NC score	0.121600 (rank : 1275)	θ value	8.99809 (rank : 1539)
Query Neighborhood Hits	1580	Target Neighborhood Hits	635	Shared Neighborhood Hits	267
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

SIG11_HUMAN
NC score	0.121547 (rank : 1276)	θ value	0.279714 (rank : 1198)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	208
SwissProt Accessions	Q96RL6	Gene names	SIGLEC11
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 11 precursor (Siglec-11) (Sialic acid-binding lectin 11).

CNTRB_HUMAN
NC score	0.121417 (rank : 1277)	θ value	θ > 10 (rank : 1716)
Query Neighborhood Hits	1580	Target Neighborhood Hits	690	Shared Neighborhood Hits	271
SwissProt Accessions	Q8N137, Q331K3, Q69YV7, Q8NCB8, Q8WXV3, Q96CQ7, Q9C060	Gene names	CNTROB, LIP8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

GRAP2_MOUSE
NC score	0.121347 (rank : 1278)	θ value	θ > 10 (rank : 1800)
Query Neighborhood Hits	1580	Target Neighborhood Hits	297	Shared Neighborhood Hits	107
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SLAP2_MOUSE
NC score	0.121340 (rank : 1279)	θ value	θ > 10 (rank : 2106)
Query Neighborhood Hits	1580	Target Neighborhood Hits	136	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

RUFY1_MOUSE
NC score	0.121262 (rank : 1280)	θ value	θ > 10 (rank : 2068)
Query Neighborhood Hits	1580	Target Neighborhood Hits	765	Shared Neighborhood Hits	298
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

NRG2_HUMAN
NC score	0.121255 (rank : 1281)	θ value	8.99809 (rank : 1551)
Query Neighborhood Hits	1580	Target Neighborhood Hits	419	Shared Neighborhood Hits	219
SwissProt Accessions	O14511	Gene names	NRG2, NTAK
Domain Architecture
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Neural- and thymus-derived activator for ERBB kinases) (NTAK) (Divergent of neuregulin-1) (DON-1)].

RIMB1_HUMAN
NC score	0.120866 (rank : 1282)	θ value	1.81305 (rank : 1339)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1479	Shared Neighborhood Hits	422
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

GAS8_MOUSE
NC score	0.120747 (rank : 1283)	θ value	θ > 10 (rank : 1785)
Query Neighborhood Hits	1580	Target Neighborhood Hits	622	Shared Neighborhood Hits	256
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

SLAP2_HUMAN
NC score	0.120703 (rank : 1284)	θ value	θ > 10 (rank : 2105)
Query Neighborhood Hits	1580	Target Neighborhood Hits	139	Shared Neighborhood Hits	66
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

RRBP1_HUMAN
NC score	0.120441 (rank : 1285)	θ value	0.21417 (rank : 1178)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1306	Shared Neighborhood Hits	347
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

CCD91_MOUSE
NC score	0.120416 (rank : 1286)	θ value	0.47712 (rank : 1222)
Query Neighborhood Hits	1580	Target Neighborhood Hits	699	Shared Neighborhood Hits	266
SwissProt Accessions	Q9D8L5, Q8R3N8, Q9D9E8	Gene names	Ccdc91, Ggabp
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner).

ACTN4_HUMAN
NC score	0.120408 (rank : 1287)	θ value	0.0330416 (rank : 1076)
Query Neighborhood Hits	1580	Target Neighborhood Hits	279	Shared Neighborhood Hits	141
SwissProt Accessions	O43707, O76048	Gene names	ACTN4
Domain Architecture
Description	Alpha-actinin-4 (Non-muscle alpha-actinin 4) (F-actin cross-linking protein).

LIPA2_HUMAN
NC score	0.120358 (rank : 1288)	θ value	θ > 10 (rank : 1881)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1044	Shared Neighborhood Hits	323
SwissProt Accessions	O75334	Gene names	PPFIA2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

CCD91_HUMAN
NC score	0.120219 (rank : 1289)	θ value	8.99809 (rank : 1528)
Query Neighborhood Hits	1580	Target Neighborhood Hits	868	Shared Neighborhood Hits	289
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

FNDC3_MOUSE
NC score	0.120024 (rank : 1290)	θ value	θ > 10 (rank : 1783)
Query Neighborhood Hits	1580	Target Neighborhood Hits	207	Shared Neighborhood Hits	114
SwissProt Accessions	Q8BX90, Q2VEY7, Q6ZQ15, Q811D3, Q8BTM3	Gene names	Fndc3a, D14Ertd453e, Fndc3, Kiaa0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

FNDC3_HUMAN
NC score	0.119930 (rank : 1291)	θ value	θ > 10 (rank : 1782)
Query Neighborhood Hits	1580	Target Neighborhood Hits	196	Shared Neighborhood Hits	113
SwissProt Accessions	Q9Y2H6, Q5JVF9, Q6EVH3, Q6N020, Q6P9D5, Q9H1W1	Gene names	FNDC3A, FNDC3, KIAA0970
Domain Architecture	No domain graphic available
Description	Fibronectin type-III domain-containing protein 3a.

MUC18_HUMAN
NC score	0.119761 (rank : 1292)	θ value	θ > 10 (rank : 1929)
Query Neighborhood Hits	1580	Target Neighborhood Hits	275	Shared Neighborhood Hits	192
SwissProt Accessions	P43121, O95812, Q59E86, Q6PHR3, Q6ZTR2	Gene names	MCAM, MUC18
Domain Architecture
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (S-endo 1 endothelial-associated antigen) (Cell surface glycoprotein P1H12) (CD146 antigen).

SAS6_HUMAN
NC score	0.119692 (rank : 1293)	θ value	0.47712 (rank : 1232)
Query Neighborhood Hits	1580	Target Neighborhood Hits	791	Shared Neighborhood Hits	282
SwissProt Accessions	Q6UVJ0, Q8N3K0	Gene names	SASS6, SAS6
Domain Architecture	No domain graphic available
Description	Spindle assembly abnormal protein 6 homolog (HsSAS-6).

SIG10_HUMAN
NC score	0.119636 (rank : 1294)	θ value	0.813845 (rank : 1266)
Query Neighborhood Hits	1580	Target Neighborhood Hits	363	Shared Neighborhood Hits	222
SwissProt Accessions	Q96LC7, Q6UXI8, Q96G54, Q96LC8	Gene names	SIGLEC10, SLG2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 10 precursor (Siglec-10) (Siglec- like protein 2).

LRFN3_HUMAN
NC score	0.119591 (rank : 1295)	θ value	1.87187e-05 (rank : 815)
Query Neighborhood Hits	1580	Target Neighborhood Hits	444	Shared Neighborhood Hits	199
SwissProt Accessions	Q9BTN0, Q6UY10	Gene names	LRFN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor.

CARD9_HUMAN
NC score	0.119579 (rank : 1296)	θ value	θ > 10 (rank : 1645)
Query Neighborhood Hits	1580	Target Neighborhood Hits	602	Shared Neighborhood Hits	268
SwissProt Accessions	Q9H257, Q5SXM6, Q9H854	Gene names	CARD9
Domain Architecture
Description	Caspase recruitment domain-containing protein 9 (hCARD9).

NRG2_MOUSE
NC score	0.119360 (rank : 1297)	θ value	2.36792 (rank : 1365)
Query Neighborhood Hits	1580	Target Neighborhood Hits	392	Shared Neighborhood Hits	209
SwissProt Accessions	P56974	Gene names	Nrg2
Domain Architecture	No domain graphic available
Description	Pro-neuregulin-2, membrane-bound isoform precursor (Pro-NRG2) [Contains: Neuregulin-2 (NRG-2) (Divergent of neuregulin 1) (DON-1)].

SMC2_HUMAN
NC score	0.119292 (rank : 1298)	θ value	6.88961 (rank : 1515)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1405	Shared Neighborhood Hits	349
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

ACTN3_MOUSE
NC score	0.119198 (rank : 1299)	θ value	0.00102713 (rank : 952)
Query Neighborhood Hits	1580	Target Neighborhood Hits	265	Shared Neighborhood Hits	133
SwissProt Accessions	O88990	Gene names	Actn3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

C102B_HUMAN
NC score	0.119143 (rank : 1300)	θ value	0.62314 (rank : 1235)
Query Neighborhood Hits	1580	Target Neighborhood Hits	542	Shared Neighborhood Hits	232
SwissProt Accessions	Q68D86, Q7Z467, Q8NDK7, Q9H5C1	Gene names	CCDC102B, C18orf14
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 102B.

MUC18_MOUSE
NC score	0.119015 (rank : 1301)	θ value	θ > 10 (rank : 1930)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	192
SwissProt Accessions	Q8R2Y2, Q9EPF1, Q9ESS7, Q9JHQ2, Q9JHQ3	Gene names	Mcam, Muc18
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein MUC18 precursor (Melanoma-associated antigen MUC18) (Melanoma cell adhesion molecule) (Gicerin).

MYO5C_HUMAN
NC score	0.118990 (rank : 1302)	θ value	1.06291 (rank : 1285)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1206	Shared Neighborhood Hits	352
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

TUFT1_HUMAN
NC score	0.118949 (rank : 1303)	θ value	0.0431538 (rank : 1099)
Query Neighborhood Hits	1580	Target Neighborhood Hits	686	Shared Neighborhood Hits	281
SwissProt Accessions	Q9NNX1, Q5T384, Q5T385, Q9BU28, Q9H5L1	Gene names	TUFT1
Domain Architecture	No domain graphic available
Description	Tuftelin.

DYNA_HUMAN
NC score	0.118768 (rank : 1304)	θ value	1.06291 (rank : 1276)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1194	Shared Neighborhood Hits	350
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

BRE1B_HUMAN
NC score	0.118596 (rank : 1305)	θ value	4.03905 (rank : 1419)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1040	Shared Neighborhood Hits	315
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

LIPA1_HUMAN
NC score	0.118147 (rank : 1306)	θ value	0.279714 (rank : 1194)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1294	Shared Neighborhood Hits	344
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

BICD1_HUMAN
NC score	0.118027 (rank : 1307)	θ value	θ > 10 (rank : 1626)
Query Neighborhood Hits	1580	Target Neighborhood Hits	844	Shared Neighborhood Hits	303
SwissProt Accessions	Q96G01, O43892, O43893	Gene names	BICD1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

LRFN5_MOUSE
NC score	0.118012 (rank : 1308)	θ value	1.53129e-07 (rank : 654)
Query Neighborhood Hits	1580	Target Neighborhood Hits	472	Shared Neighborhood Hits	209
SwissProt Accessions	Q8BXA0, Q8BJH4, Q8BZL0	Gene names	Lrfn5
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

ANR26_MOUSE
NC score	0.117912 (rank : 1309)	θ value	θ > 10 (rank : 1610)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1554	Shared Neighborhood Hits	371
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

LUZP1_HUMAN
NC score	0.117861 (rank : 1310)	θ value	θ > 10 (rank : 1898)
Query Neighborhood Hits	1580	Target Neighborhood Hits	739	Shared Neighborhood Hits	269
SwissProt Accessions	Q86V48, Q5TH93, Q8N4X3, Q8TEH1	Gene names	LUZP1
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1.

CCD27_MOUSE
NC score	0.117844 (rank : 1311)	θ value	1.81305 (rank : 1322)
Query Neighborhood Hits	1580	Target Neighborhood Hits	461	Shared Neighborhood Hits	227
SwissProt Accessions	Q3V036	Gene names	Ccdc27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

RPGR1_HUMAN
NC score	0.117640 (rank : 1312)	θ value	0.0252991 (rank : 1074)
Query Neighborhood Hits	1580	Target Neighborhood Hits	578	Shared Neighborhood Hits	244
SwissProt Accessions	Q96KN7, Q7Z2W6, Q8IXV5, Q96QA8, Q9HB94, Q9HB95, Q9HBK6, Q9NR40	Gene names	RPGRIP1
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

CCDC6_HUMAN
NC score	0.117631 (rank : 1313)	θ value	θ > 10 (rank : 1664)
Query Neighborhood Hits	1580	Target Neighborhood Hits	723	Shared Neighborhood Hits	279
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

BUB1B_HUMAN
NC score	0.117563 (rank : 1314)	θ value	8.99809 (rank : 1524)
Query Neighborhood Hits	1580	Target Neighborhood Hits	208	Shared Neighborhood Hits	148
SwissProt Accessions	O60566, O60501, O60627, O60758, O75389, Q96KM4	Gene names	BUB1B, BUBR1, MAD3L
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (hBUBR1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L) (SSK1).

CEAM1_MOUSE
NC score	0.117373 (rank : 1315)	θ value	0.163984 (rank : 1158)
Query Neighborhood Hits	1580	Target Neighborhood Hits	326	Shared Neighborhood Hits	210
SwissProt Accessions	P31809	Gene names	Ceacam1, Bgp, Bgp1, Bgpd
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (Murine hepatitis virus receptor) (MHV-R) (Biliary glycoprotein D).

BRE1B_MOUSE
NC score	0.117350 (rank : 1316)	θ value	4.03905 (rank : 1420)
Query Neighborhood Hits	1580	Target Neighborhood Hits	970	Shared Neighborhood Hits	302
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

GNRP_MOUSE
NC score	0.117227 (rank : 1317)	θ value	θ > 10 (rank : 1795)
Query Neighborhood Hits	1580	Target Neighborhood Hits	191	Shared Neighborhood Hits	91
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GCC1_MOUSE
NC score	0.117195 (rank : 1318)	θ value	θ > 10 (rank : 1787)
Query Neighborhood Hits	1580	Target Neighborhood Hits	777	Shared Neighborhood Hits	285
SwissProt Accessions	Q9D4H2, Q8CCR3	Gene names	Gcc1
Domain Architecture	No domain graphic available
Description	GRIP and coiled-coil domain-containing protein 1 (Golgi coiled coil protein 1).

RRBP1_MOUSE
NC score	0.117130 (rank : 1319)	θ value	0.47712 (rank : 1231)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1650	Shared Neighborhood Hits	374
SwissProt Accessions	Q99PL5, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q9CS20	Gene names	Rrbp1
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (mRRp).

UACA_MOUSE
NC score	0.117105 (rank : 1320)	θ value	θ > 10 (rank : 2187)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1620	Shared Neighborhood Hits	370
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

LIPA2_MOUSE
NC score	0.117057 (rank : 1321)	θ value	1.81305 (rank : 1332)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1282	Shared Neighborhood Hits	342
SwissProt Accessions	Q8BSS9, Q8BN73	Gene names	Ppfia2
Domain Architecture
Description	Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2).

ANR26_HUMAN
NC score	0.117030 (rank : 1322)	θ value	2.36792 (rank : 1346)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1614	Shared Neighborhood Hits	365
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ACTN1_HUMAN
NC score	0.116920 (rank : 1323)	θ value	0.00665767 (rank : 1012)
Query Neighborhood Hits	1580	Target Neighborhood Hits	221	Shared Neighborhood Hits	104
SwissProt Accessions	P12814, Q9BTN1	Gene names	ACTN1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

UACA_HUMAN
NC score	0.116910 (rank : 1324)	θ value	1.06291 (rank : 1294)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1622	Shared Neighborhood Hits	368
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

DYNA_MOUSE
NC score	0.116746 (rank : 1325)	θ value	1.06291 (rank : 1277)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1084	Shared Neighborhood Hits	338
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

BICD1_MOUSE
NC score	0.116344 (rank : 1326)	θ value	θ > 10 (rank : 1627)
Query Neighborhood Hits	1580	Target Neighborhood Hits	837	Shared Neighborhood Hits	296
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

ACTN2_HUMAN
NC score	0.116242 (rank : 1327)	θ value	0.0961366 (rank : 1125)
Query Neighborhood Hits	1580	Target Neighborhood Hits	295	Shared Neighborhood Hits	143
SwissProt Accessions	P35609, Q86TF4, Q86TI8	Gene names	ACTN2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

IF3A_MOUSE
NC score	0.116063 (rank : 1328)	θ value	θ > 10 (rank : 1826)
Query Neighborhood Hits	1580	Target Neighborhood Hits	871	Shared Neighborhood Hits	288
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

LRFN5_HUMAN
NC score	0.116015 (rank : 1329)	θ value	3.41135e-07 (rank : 668)
Query Neighborhood Hits	1580	Target Neighborhood Hits	464	Shared Neighborhood Hits	207
SwissProt Accessions	Q96NI6, Q86XL2	Gene names	LRFN5, C14orf146
Domain Architecture
Description	Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.

CCD27_HUMAN
NC score	0.115927 (rank : 1330)	θ value	θ > 10 (rank : 1653)
Query Neighborhood Hits	1580	Target Neighborhood Hits	594	Shared Neighborhood Hits	255
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

MPP9_HUMAN
NC score	0.115879 (rank : 1331)	θ value	θ > 10 (rank : 1926)
Query Neighborhood Hits	1580	Target Neighborhood Hits	529	Shared Neighborhood Hits	243
SwissProt Accessions	Q99550, Q9H976	Gene names	MPHOSPH9, MPP9
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 9.

CEA20_HUMAN
NC score	0.115856 (rank : 1332)	θ value	0.0431538 (rank : 1084)
Query Neighborhood Hits	1580	Target Neighborhood Hits	251	Shared Neighborhood Hits	168
SwissProt Accessions	Q6UY09	Gene names	CEACAM20
Domain Architecture	No domain graphic available
Description	Carcinoembryonic antigen-related cell adhesion molecule 20 precursor.

CCD93_HUMAN
NC score	0.115664 (rank : 1333)	θ value	θ > 10 (rank : 1660)
Query Neighborhood Hits	1580	Target Neighborhood Hits	600	Shared Neighborhood Hits	255
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

KNTC2_MOUSE
NC score	0.115373 (rank : 1334)	θ value	θ > 10 (rank : 1873)
Query Neighborhood Hits	1580	Target Neighborhood Hits	692	Shared Neighborhood Hits	269
SwissProt Accessions	Q9D0F1, Q3TQT6, Q3UWM5, Q99P70	Gene names	Kntc2, Hec1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (Kinetochore-associated protein 2).

RUFY2_MOUSE
NC score	0.115182 (rank : 1335)	θ value	θ > 10 (rank : 2069)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	295
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

ACTN1_MOUSE
NC score	0.115096 (rank : 1336)	θ value	0.00665767 (rank : 1013)
Query Neighborhood Hits	1580	Target Neighborhood Hits	216	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TPR4	Gene names	Actn1
Domain Architecture
Description	Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (Non-muscle alpha-actinin-1) (F-actin cross-linking protein).

CCD96_MOUSE
NC score	0.115004 (rank : 1337)	θ value	θ > 10 (rank : 1663)
Query Neighborhood Hits	1580	Target Neighborhood Hits	704	Shared Neighborhood Hits	275
SwissProt Accessions	Q9CR92	Gene names	Ccdc96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

ACTN3_HUMAN
NC score	0.114977 (rank : 1338)	θ value	0.0148317 (rank : 1041)
Query Neighborhood Hits	1580	Target Neighborhood Hits	272	Shared Neighborhood Hits	129
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

IF3A_HUMAN
NC score	0.114874 (rank : 1339)	θ value	θ > 10 (rank : 1825)
Query Neighborhood Hits	1580	Target Neighborhood Hits	875	Shared Neighborhood Hits	293
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

CEAM5_HUMAN
NC score	0.114582 (rank : 1340)	θ value	6.88961 (rank : 1481)
Query Neighborhood Hits	1580	Target Neighborhood Hits	343	Shared Neighborhood Hits	211
SwissProt Accessions	P06731	Gene names	CEACAM5, CEA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 5 precursor (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD66e antigen).

NUF2_HUMAN
NC score	0.114462 (rank : 1341)	θ value	θ > 10 (rank : 1976)
Query Neighborhood Hits	1580	Target Neighborhood Hits	661	Shared Neighborhood Hits	259
SwissProt Accessions	Q9BZD4, Q8WU69, Q96HJ4, Q96Q78	Gene names	CDCA1, NUF2, NUF2R
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (hNuf2) (hNuf2R) (hsNuf2) (Cell division cycle-associated protein 1).

RFIP3_HUMAN
NC score	0.114319 (rank : 1342)	θ value	0.21417 (rank : 1177)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1055	Shared Neighborhood Hits	330
SwissProt Accessions	O75154, Q4VXV7, Q9H155, Q9H1G0, Q9NUI0	Gene names	RAB11FIP3, KIAA0665
Domain Architecture
Description	Rab11 family-interacting protein 3 (Rab11-FIP3) (EF hands-containing Rab-interacting protein) (Eferin).

GRP3_HUMAN
NC score	0.114189 (rank : 1343)	θ value	θ > 10 (rank : 1805)
Query Neighborhood Hits	1580	Target Neighborhood Hits	131	Shared Neighborhood Hits	52
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

CKAP4_MOUSE
NC score	0.114134 (rank : 1344)	θ value	θ > 10 (rank : 1705)
Query Neighborhood Hits	1580	Target Neighborhood Hits	596	Shared Neighborhood Hits	244
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

XE7_HUMAN
NC score	0.114128 (rank : 1345)	θ value	θ > 10 (rank : 2212)
Query Neighborhood Hits	1580	Target Neighborhood Hits	738	Shared Neighborhood Hits	267
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

ACTN2_MOUSE
NC score	0.113982 (rank : 1346)	θ value	0.0961366 (rank : 1126)
Query Neighborhood Hits	1580	Target Neighborhood Hits	287	Shared Neighborhood Hits	138
SwissProt Accessions	Q9JI91	Gene names	Actn2
Domain Architecture
Description	Alpha-actinin-2 (Alpha actinin skeletal muscle isoform 2) (F-actin cross-linking protein).

SPAG5_HUMAN
NC score	0.113792 (rank : 1347)	θ value	θ > 10 (rank : 2110)
Query Neighborhood Hits	1580	Target Neighborhood Hits	625	Shared Neighborhood Hits	265
SwissProt Accessions	Q96R06, O95213, Q9BWE8, Q9NT17, Q9UFE6	Gene names	SPAG5
Domain Architecture	No domain graphic available
Description	Sperm-associated antigen 5 (Astrin) (Mitotic spindle-associated protein p126) (MAP126) (Deepest).

BICD2_MOUSE
NC score	0.113729 (rank : 1348)	θ value	θ > 10 (rank : 1629)
Query Neighborhood Hits	1580	Target Neighborhood Hits	864	Shared Neighborhood Hits	287
SwissProt Accessions	Q921C5, Q80TU1, Q8BTE3, Q9DCL3	Gene names	Bicd2, Kiaa0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

OPTN_HUMAN
NC score	0.113597 (rank : 1349)	θ value	θ > 10 (rank : 1980)
Query Neighborhood Hits	1580	Target Neighborhood Hits	827	Shared Neighborhood Hits	285
SwissProt Accessions	Q96CV9, Q5T672, Q5T673, Q5T674, Q5T675, Q7LDL9, Q8N562, Q9UET9, Q9UEV4, Q9Y218	Gene names	OPTN, FIP2, GLC1E, NRP
Domain Architecture	No domain graphic available
Description	Optineurin (Optic neuropathy-inducing protein) (E3-14.7K-interacting protein) (FIP-2) (Huntingtin-interacting protein HYPL) (NEMO-related protein) (Transcription factor IIIA-interacting protein) (TFIIIA- IntP).

CEP55_MOUSE
NC score	0.113543 (rank : 1350)	θ value	θ > 10 (rank : 1683)
Query Neighborhood Hits	1580	Target Neighborhood Hits	693	Shared Neighborhood Hits	272
SwissProt Accessions	Q8BT07, Q8C2J0, Q8K2I8, Q8R2Y4, Q9DBZ8	Gene names	Cep55
Domain Architecture	No domain graphic available
Description	Centrosome protein 55.

EP15R_HUMAN
NC score	0.113452 (rank : 1351)	θ value	0.163984 (rank : 1159)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1083	Shared Neighborhood Hits	330
SwissProt Accessions	Q9UBC2	Gene names	EPS15L1, EPS15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R).

HIP1R_MOUSE
NC score	0.113223 (rank : 1352)	θ value	2.36792 (rank : 1355)
Query Neighborhood Hits	1580	Target Neighborhood Hits	959	Shared Neighborhood Hits	319
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

NAF1_MOUSE
NC score	0.113083 (rank : 1353)	θ value	θ > 10 (rank : 1953)
Query Neighborhood Hits	1580	Target Neighborhood Hits	852	Shared Neighborhood Hits	302
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

CEP55_HUMAN
NC score	0.112705 (rank : 1354)	θ value	θ > 10 (rank : 1682)
Query Neighborhood Hits	1580	Target Neighborhood Hits	504	Shared Neighborhood Hits	246
SwissProt Accessions	Q53EZ4, Q32WF5, Q3MV20, Q5VY28, Q6N034, Q96H32, Q9NVS7	Gene names	CEP55, C10orf3, URCC6
Domain Architecture	No domain graphic available
Description	Centrosome protein 55 (Up-regulated in colon cancer 6).

NUF2_MOUSE
NC score	0.112548 (rank : 1355)	θ value	θ > 10 (rank : 1977)
Query Neighborhood Hits	1580	Target Neighborhood Hits	585	Shared Neighborhood Hits	257
SwissProt Accessions	Q99P69, Q8BTK7, Q8VE05, Q9CST5	Gene names	Cdca1, Nuf2r
Domain Architecture	No domain graphic available
Description	Kinetochore protein Nuf2 (Cell division cycle-associated protein 1).

HIP1_HUMAN
NC score	0.112257 (rank : 1356)	θ value	θ > 10 (rank : 1813)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1016	Shared Neighborhood Hits	316
SwissProt Accessions	O00291, O00328, Q8TDL4	Gene names	HIP1
Domain Architecture
Description	Huntingtin-interacting protein 1 (HIP-I).

PHLB2_MOUSE
NC score	0.112190 (rank : 1357)	θ value	8.99809 (rank : 1554)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1016	Shared Neighborhood Hits	331
SwissProt Accessions	Q8K1N2, Q3TNI3, Q80Y16, Q8BKV3	Gene names	Phldb2, Ll5b
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

BICD2_HUMAN
NC score	0.112160 (rank : 1358)	θ value	θ > 10 (rank : 1628)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	288
SwissProt Accessions	Q8TD16, O75181, Q5TBQ2, Q5TBQ3, Q96LH2, Q9BT84, Q9H561	Gene names	BICD2, KIAA0699
Domain Architecture
Description	Cytoskeleton-like bicaudal D protein homolog 2.

ABR_HUMAN
NC score	0.111831 (rank : 1359)	θ value	0.00102713 (rank : 951)
Query Neighborhood Hits	1580	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

CKAP4_HUMAN
NC score	0.111776 (rank : 1360)	θ value	θ > 10 (rank : 1704)
Query Neighborhood Hits	1580	Target Neighborhood Hits	592	Shared Neighborhood Hits	236
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

LRRF2_HUMAN
NC score	0.111635 (rank : 1361)	θ value	θ > 10 (rank : 1896)
Query Neighborhood Hits	1580	Target Neighborhood Hits	791	Shared Neighborhood Hits	287
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

CCD96_HUMAN
NC score	0.111383 (rank : 1362)	θ value	θ > 10 (rank : 1662)
Query Neighborhood Hits	1580	Target Neighborhood Hits	595	Shared Neighborhood Hits	254
SwissProt Accessions	Q2M329, Q8N2I7	Gene names	CCDC96
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 96.

TRAK1_HUMAN
NC score	0.111375 (rank : 1363)	θ value	0.365318 (rank : 1220)
Query Neighborhood Hits	1580	Target Neighborhood Hits	660	Shared Neighborhood Hits	273
SwissProt Accessions	Q9UPV9, Q96B69	Gene names	TRAK1, KIAA1042, OIP106
Domain Architecture	No domain graphic available
Description	Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase- interacting protein).

BCR_HUMAN
NC score	0.111287 (rank : 1364)	θ value	1.09739e-05 (rank : 778)
Query Neighborhood Hits	1580	Target Neighborhood Hits	204	Shared Neighborhood Hits	79
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

LRC21_MOUSE
NC score	0.111207 (rank : 1365)	θ value	4.1701e-05 (rank : 839)
Query Neighborhood Hits	1580	Target Neighborhood Hits	462	Shared Neighborhood Hits	211
SwissProt Accessions	Q8K099, Q8BXN3	Gene names	Lrrc21, Pal
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

SLAP1_HUMAN
NC score	0.111118 (rank : 1366)	θ value	θ > 10 (rank : 2103)
Query Neighborhood Hits	1580	Target Neighborhood Hits	113	Shared Neighborhood Hits	49
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

GNRP_HUMAN
NC score	0.111032 (rank : 1367)	θ value	θ > 10 (rank : 1794)
Query Neighborhood Hits	1580	Target Neighborhood Hits	239	Shared Neighborhood Hits	112
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

TXLNA_MOUSE
NC score	0.110893 (rank : 1368)	θ value	2.36792 (rank : 1373)
Query Neighborhood Hits	1580	Target Neighborhood Hits	846	Shared Neighborhood Hits	300
SwissProt Accessions	Q6PAM1, Q6P1E5	Gene names	Txlna, Txln
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

KNTC2_HUMAN
NC score	0.110744 (rank : 1369)	θ value	θ > 10 (rank : 1872)
Query Neighborhood Hits	1580	Target Neighborhood Hits	673	Shared Neighborhood Hits	266
SwissProt Accessions	O14777, Q6PJX2	Gene names	KNTC2, HEC, HEC1
Domain Architecture	No domain graphic available
Description	Kinetochore protein Hec1 (HsHec1) (Kinetochore-associated protein 2) (Highly expressed in cancer protein) (Retinoblastoma-associated protein HEC).

LRRN3_HUMAN
NC score	0.110696 (rank : 1370)	θ value	9.92553e-07 (rank : 710)
Query Neighborhood Hits	1580	Target Neighborhood Hits	461	Shared Neighborhood Hits	203
SwissProt Accessions	Q9H3W5, O43377, Q6I9V8, Q8IYQ6	Gene names	LRRN3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

PHLB2_HUMAN
NC score	0.110529 (rank : 1371)	θ value	1.81305 (rank : 1336)
Query Neighborhood Hits	1580	Target Neighborhood Hits	964	Shared Neighborhood Hits	324
SwissProt Accessions	Q86SQ0, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5	Gene names	PHLDB2, LL5B
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 2 (Protein LL5-beta).

NAF1_HUMAN
NC score	0.110516 (rank : 1372)	θ value	θ > 10 (rank : 1952)
Query Neighborhood Hits	1580	Target Neighborhood Hits	937	Shared Neighborhood Hits	307
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

T3JAM_HUMAN
NC score	0.110432 (rank : 1373)	θ value	θ > 10 (rank : 2140)
Query Neighborhood Hits	1580	Target Neighborhood Hits	533	Shared Neighborhood Hits	248
SwissProt Accessions	Q9Y228, Q2YDB5, Q4VY06, Q7Z706	Gene names	TRAF3IP3, T3JAM
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

NPHP1_MOUSE
NC score	0.110429 (rank : 1374)	θ value	0.00298849 (rank : 991)
Query Neighborhood Hits	1580	Target Neighborhood Hits	267	Shared Neighborhood Hits	121
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

LRC21_HUMAN
NC score	0.110352 (rank : 1375)	θ value	0.00020696 (rank : 893)
Query Neighborhood Hits	1580	Target Neighborhood Hits	456	Shared Neighborhood Hits	207
SwissProt Accessions	Q9P2V4, Q9Y4N7	Gene names	LRRC21, PAL
Domain Architecture
Description	Leucine-rich repeat-containing protein 21 precursor (Photoreceptor- associated LRR superfamily protein) (Retina-specific protein PAL).

MYO5A_HUMAN
NC score	0.110234 (rank : 1376)	θ value	θ > 10 (rank : 1943)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1092	Shared Neighborhood Hits	321
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

CTGE5_MOUSE
NC score	0.110217 (rank : 1377)	θ value	θ > 10 (rank : 1733)
Query Neighborhood Hits	1580	Target Neighborhood Hits	928	Shared Neighborhood Hits	305
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

TPM3_HUMAN
NC score	0.109735 (rank : 1378)	θ value	5.27518 (rank : 1471)
Query Neighborhood Hits	1580	Target Neighborhood Hits	689	Shared Neighborhood Hits	271
SwissProt Accessions	P06753, P12324, Q969Q2, Q9NQH8	Gene names	TPM3
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma) (hTM5).

EP15R_MOUSE
NC score	0.109591 (rank : 1379)	θ value	θ > 10 (rank : 1764)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1135	Shared Neighborhood Hits	332
SwissProt Accessions	Q60902, Q8CB60, Q8CB70, Q91WH8	Gene names	Eps15l1, Eps15-rs, Eps15R
Domain Architecture
Description	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R) (Epidermal growth factor receptor pathway substrate 15-related sequence) (Eps15-rs).

SLAP1_MOUSE
NC score	0.109494 (rank : 1380)	θ value	θ > 10 (rank : 2104)
Query Neighborhood Hits	1580	Target Neighborhood Hits	117	Shared Neighborhood Hits	51
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

CUTL1_HUMAN
NC score	0.109226 (rank : 1381)	θ value	2.36792 (rank : 1351)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1574	Shared Neighborhood Hits	378
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

SMC4_HUMAN
NC score	0.108503 (rank : 1382)	θ value	θ > 10 (rank : 2108)
Query Neighborhood Hits	1580	Target Neighborhood Hits	937	Shared Neighborhood Hits	296
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

ATL3_HUMAN
NC score	0.108322 (rank : 1383)	θ value	1.87187e-05 (rank : 803)
Query Neighborhood Hits	1580	Target Neighborhood Hits	414	Shared Neighborhood Hits	232
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

TPM3_MOUSE
NC score	0.108101 (rank : 1384)	θ value	8.99809 (rank : 1573)
Query Neighborhood Hits	1580	Target Neighborhood Hits	676	Shared Neighborhood Hits	268
SwissProt Accessions	P21107, Q09021, Q60606, Q80SW6, Q9EPW3	Gene names	Tpm3, Tpm-5, Tpm5
Domain Architecture
Description	Tropomyosin alpha-3 chain (Tropomyosin-3) (Tropomyosin gamma).

NDE1_HUMAN
NC score	0.108067 (rank : 1385)	θ value	θ > 10 (rank : 1959)
Query Neighborhood Hits	1580	Target Neighborhood Hits	823	Shared Neighborhood Hits	301
SwissProt Accessions	Q9NXR1, Q49AQ2	Gene names	NDE1, NUDE
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE).

CA065_HUMAN
NC score	0.107934 (rank : 1386)	θ value	θ > 10 (rank : 1636)
Query Neighborhood Hits	1580	Target Neighborhood Hits	469	Shared Neighborhood Hits	211
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

CUTL1_MOUSE
NC score	0.107789 (rank : 1387)	θ value	1.81305 (rank : 1324)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1620	Shared Neighborhood Hits	370
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

TXLNA_HUMAN
NC score	0.107722 (rank : 1388)	θ value	θ > 10 (rank : 2179)
Query Neighborhood Hits	1580	Target Neighborhood Hits	982	Shared Neighborhood Hits	315
SwissProt Accessions	P40222, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3	Gene names	TXLNA, TXLN
Domain Architecture	No domain graphic available
Description	Alpha-taxilin.

MYO5A_MOUSE
NC score	0.107652 (rank : 1389)	θ value	θ > 10 (rank : 1944)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1117	Shared Neighborhood Hits	314
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MIPO1_HUMAN
NC score	0.107628 (rank : 1390)	θ value	θ > 10 (rank : 1922)
Query Neighborhood Hits	1580	Target Neighborhood Hits	486	Shared Neighborhood Hits	242
SwissProt Accessions	Q8TD10, Q7Z3J0, Q8IV14	Gene names	MIPOL1
Domain Architecture	No domain graphic available
Description	Mirror-image polydactyly gene 1 protein.

CTGE5_HUMAN
NC score	0.107427 (rank : 1391)	θ value	0.813845 (rank : 1254)
Query Neighborhood Hits	1580	Target Neighborhood Hits	800	Shared Neighborhood Hits	291
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

SMC4_MOUSE
NC score	0.107372 (rank : 1392)	θ value	8.99809 (rank : 1566)
Query Neighborhood Hits	1580	Target Neighborhood Hits	830	Shared Neighborhood Hits	287
SwissProt Accessions	Q8CG47, Q8BTS7, Q8BTY9, Q99K21	Gene names	Smc4l1, Capc, Smc4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (XCAP-C homolog).

TNIP3_HUMAN
NC score	0.107328 (rank : 1393)	θ value	θ > 10 (rank : 2159)
Query Neighborhood Hits	1580	Target Neighborhood Hits	511	Shared Neighborhood Hits	229
SwissProt Accessions	Q96KP6, Q96PQ3, Q9H780	Gene names	TNIP3, ABIN3, LIND
Domain Architecture	No domain graphic available
Description	TNFAIP3-interacting protein 3 (Listeria-induced gene protein) (A20- binding inhibitor of NF-kappa-B activation 3) (ABIN-3).

LRRN1_HUMAN
NC score	0.107230 (rank : 1394)	θ value	4.0297e-08 (rank : 620)
Query Neighborhood Hits	1580	Target Neighborhood Hits	518	Shared Neighborhood Hits	221
SwissProt Accessions	Q6UXK5, Q3LID5, Q8IYV5, Q9H8V1, Q9P231	Gene names	LRRN1, KIAA1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

RABE2_MOUSE
NC score	0.107147 (rank : 1395)	θ value	θ > 10 (rank : 2042)
Query Neighborhood Hits	1580	Target Neighborhood Hits	598	Shared Neighborhood Hits	257
SwissProt Accessions	Q91WG2, Q99KN3	Gene names	Rabep2, Rabpt5b
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

TPM1_MOUSE
NC score	0.107070 (rank : 1396)	θ value	θ > 10 (rank : 2165)
Query Neighborhood Hits	1580	Target Neighborhood Hits	729	Shared Neighborhood Hits	275
SwissProt Accessions	P58771, P02558, P19354, P46902, P99034	Gene names	Tpm1, Tpm-1, Tpma
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

TUFT1_MOUSE
NC score	0.106911 (rank : 1397)	θ value	θ > 10 (rank : 2178)
Query Neighborhood Hits	1580	Target Neighborhood Hits	732	Shared Neighborhood Hits	274
SwissProt Accessions	O08970	Gene names	Tuft1
Domain Architecture
Description	Tuftelin.

T3JAM_MOUSE
NC score	0.106876 (rank : 1398)	θ value	θ > 10 (rank : 2141)
Query Neighborhood Hits	1580	Target Neighborhood Hits	535	Shared Neighborhood Hits	231
SwissProt Accessions	Q8C0G2, Q8BY50, Q8K1Y9	Gene names	Traf3ip3, T3jam
Domain Architecture	No domain graphic available
Description	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3).

CDR2_MOUSE
NC score	0.106459 (rank : 1399)	θ value	8.99809 (rank : 1531)
Query Neighborhood Hits	1580	Target Neighborhood Hits	482	Shared Neighborhood Hits	240
SwissProt Accessions	P97817	Gene names	Cdr2
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2.

EP15_MOUSE
NC score	0.106341 (rank : 1400)	θ value	0.0563607 (rank : 1102)
Query Neighborhood Hits	1580	Target Neighborhood Hits	820	Shared Neighborhood Hits	287
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_HUMAN
NC score	0.106096 (rank : 1401)	θ value	8.99809 (rank : 1535)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1021	Shared Neighborhood Hits	322
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

TXLNB_MOUSE
NC score	0.106090 (rank : 1402)	θ value	0.21417 (rank : 1181)
Query Neighborhood Hits	1580	Target Neighborhood Hits	640	Shared Neighborhood Hits	260
SwissProt Accessions	Q8VBT1, Q3UVB8, Q8BUK2	Gene names	Txlnb, Mdp77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77).

CF152_HUMAN
NC score	0.106043 (rank : 1403)	θ value	θ > 10 (rank : 1690)
Query Neighborhood Hits	1580	Target Neighborhood Hits	704	Shared Neighborhood Hits	265
SwissProt Accessions	Q86VQ0, Q9BWX7	Gene names	C6orf152
Domain Architecture	No domain graphic available
Description	Protein C6orf152.

LRRF2_MOUSE
NC score	0.105769 (rank : 1404)	θ value	θ > 10 (rank : 1897)
Query Neighborhood Hits	1580	Target Neighborhood Hits	556	Shared Neighborhood Hits	250
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

VDP_HUMAN
NC score	0.105609 (rank : 1405)	θ value	θ > 10 (rank : 2195)
Query Neighborhood Hits	1580	Target Neighborhood Hits	645	Shared Neighborhood Hits	253
SwissProt Accessions	O60763	Gene names	VDP
Domain Architecture
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

CF182_MOUSE
NC score	0.105347 (rank : 1406)	θ value	θ > 10 (rank : 1693)
Query Neighborhood Hits	1580	Target Neighborhood Hits	551	Shared Neighborhood Hits	243
SwissProt Accessions	Q8VDS7, Q9CZE0, Q9D5A1	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf182 homolog.

TPM1_HUMAN
NC score	0.105136 (rank : 1407)	θ value	θ > 10 (rank : 2164)
Query Neighborhood Hits	1580	Target Neighborhood Hits	716	Shared Neighborhood Hits	269
SwissProt Accessions	P09493, P09494, P10469, Q86W64, Q96IK2, Q9UCY9	Gene names	TPM1, TMSA
Domain Architecture
Description	Tropomyosin 1 alpha chain (Alpha-tropomyosin).

CEP70_MOUSE
NC score	0.105054 (rank : 1408)	θ value	θ > 10 (rank : 1687)
Query Neighborhood Hits	1580	Target Neighborhood Hits	532	Shared Neighborhood Hits	236
SwissProt Accessions	Q6IQY5, Q9CRL9, Q9CTS4, Q9JIC1	Gene names	Cep70
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein).

LRRN3_MOUSE
NC score	0.104939 (rank : 1409)	θ value	1.69304e-06 (rank : 726)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	197
SwissProt Accessions	Q8CBC6, P97860	Gene names	Lrrn3
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 3 precursor (Neuronal leucine- rich repeat protein 3) (NLRR-3).

TPM2_HUMAN
NC score	0.104762 (rank : 1410)	θ value	θ > 10 (rank : 2166)
Query Neighborhood Hits	1580	Target Neighborhood Hits	677	Shared Neighborhood Hits	262
SwissProt Accessions	P07951, P06468, Q13894, Q53FM4, Q5TCU4, Q5TCU7, Q9UH67	Gene names	TPM2, TMSB
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

TPM2_MOUSE
NC score	0.104753 (rank : 1411)	θ value	θ > 10 (rank : 2167)
Query Neighborhood Hits	1580	Target Neighborhood Hits	676	Shared Neighborhood Hits	265
SwissProt Accessions	P58774, P02560, P46901	Gene names	Tpm2, Tpm-2
Domain Architecture
Description	Tropomyosin beta chain (Tropomyosin 2) (Beta-tropomyosin).

MMRN1_HUMAN
NC score	0.104396 (rank : 1412)	θ value	1.06291 (rank : 1284)
Query Neighborhood Hits	1580	Target Neighborhood Hits	636	Shared Neighborhood Hits	218
SwissProt Accessions	Q13201, Q6P3T8	Gene names	MMRN1, ECM, EMILIN4, MMRN
Domain Architecture
Description	Multimerin-1 precursor (Endothelial cell multimerin 1) (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4).

LRRN1_MOUSE
NC score	0.104173 (rank : 1413)	θ value	5.26297e-08 (rank : 623)
Query Neighborhood Hits	1580	Target Neighborhood Hits	508	Shared Neighborhood Hits	220
SwissProt Accessions	Q61809, Q3USY1, Q69ZI0	Gene names	Lrrn1, Kiaa1497
Domain Architecture	No domain graphic available
Description	Leucine-rich repeats neuronal protein 1 precursor (Neuronal leucine- rich repeat protein 1) (NLRR-1).

CEP70_HUMAN
NC score	0.104037 (rank : 1414)	θ value	θ > 10 (rank : 1686)
Query Neighborhood Hits	1580	Target Neighborhood Hits	432	Shared Neighborhood Hits	215
SwissProt Accessions	Q8NHQ1, Q96B31, Q9H2C3, Q9H2Z1, Q9H940	Gene names	CEP70, BITE
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 70 kDa (Cep70 protein) (p10-binding protein).

RBM25_HUMAN
NC score	0.103772 (rank : 1415)	θ value	θ > 10 (rank : 2053)
Query Neighborhood Hits	1580	Target Neighborhood Hits	682	Shared Neighborhood Hits	235
SwissProt Accessions	P49756, Q9UEQ5, Q9UIE9	Gene names	RBM25, RNPC7
Domain Architecture	No domain graphic available
Description	Probable RNA-binding protein 25 (RNA-binding motif protein 25) (RNA- binding region-containing protein 7) (Protein S164).

TEX9_MOUSE
NC score	0.103634 (rank : 1416)	θ value	4.03905 (rank : 1440)
Query Neighborhood Hits	1580	Target Neighborhood Hits	581	Shared Neighborhood Hits	243
SwissProt Accessions	Q9D845, O54764	Gene names	Tex9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein (Testis-specifically expressed protein 1) (Tsec-1).

MACOI_MOUSE
NC score	0.103454 (rank : 1417)	θ value	θ > 10 (rank : 1905)
Query Neighborhood Hits	1580	Target Neighborhood Hits	620	Shared Neighborhood Hits	251
SwissProt Accessions	Q7TQE6	Gene names	Tmem57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57) (Brain-specific adaptor protein C61).

CT2NL_HUMAN
NC score	0.103285 (rank : 1418)	θ value	θ > 10 (rank : 1730)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1059	Shared Neighborhood Hits	312
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

FCRL5_HUMAN
NC score	0.103100 (rank : 1419)	θ value	θ > 10 (rank : 1774)
Query Neighborhood Hits	1580	Target Neighborhood Hits	267	Shared Neighborhood Hits	177
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

SMC2_MOUSE
NC score	0.103023 (rank : 1420)	θ value	θ > 10 (rank : 2107)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1131	Shared Neighborhood Hits	314
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

CTGE2_HUMAN
NC score	0.102781 (rank : 1421)	θ value	3.0926 (rank : 1384)
Query Neighborhood Hits	1580	Target Neighborhood Hits	594	Shared Neighborhood Hits	254
SwissProt Accessions	Q96RT6	Gene names	CTAGE1, CTAGE2
Domain Architecture	No domain graphic available
Description	Protein cTAGE-2.

CT096_HUMAN
NC score	0.102776 (rank : 1422)	θ value	1.06291 (rank : 1275)
Query Neighborhood Hits	1580	Target Neighborhood Hits	438	Shared Neighborhood Hits	219
SwissProt Accessions	Q9NUD7, Q8N840, Q8NAX5	Gene names	C20orf96
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf96.

VSIG4_HUMAN
NC score	0.102737 (rank : 1423)	θ value	θ > 10 (rank : 2207)
Query Neighborhood Hits	1580	Target Neighborhood Hits	236	Shared Neighborhood Hits	164
SwissProt Accessions	Q9Y279, Q6UXI4	Gene names	VSIG4, Z39IG
Domain Architecture	No domain graphic available
Description	V-set and immunoglobulin domain-containing protein 4 precursor (Protein Z39Ig).

TXLNB_HUMAN
NC score	0.102696 (rank : 1424)	θ value	θ > 10 (rank : 2180)
Query Neighborhood Hits	1580	Target Neighborhood Hits	912	Shared Neighborhood Hits	302
SwissProt Accessions	Q8N3L3, Q76L25, Q86T52, Q8N3S2	Gene names	TXLNB, C6orf198, MDP77
Domain Architecture	No domain graphic available
Description	Beta-taxilin (Muscle-derived protein 77) (hMDP77).

POF1B_MOUSE
NC score	0.102661 (rank : 1425)	θ value	θ > 10 (rank : 2026)
Query Neighborhood Hits	1580	Target Neighborhood Hits	530	Shared Neighborhood Hits	236
SwissProt Accessions	Q8K4L4, Q8C3A2	Gene names	Pof1b
Domain Architecture	No domain graphic available
Description	Protein POF1B.

AMOT_HUMAN
NC score	0.102591 (rank : 1426)	θ value	θ > 10 (rank : 1602)
Query Neighborhood Hits	1580	Target Neighborhood Hits	712	Shared Neighborhood Hits	265
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

HIP1R_HUMAN
NC score	0.102521 (rank : 1427)	θ value	θ > 10 (rank : 1812)
Query Neighborhood Hits	1580	Target Neighborhood Hits	809	Shared Neighborhood Hits	288
SwissProt Accessions	O75146, Q9UED9	Gene names	HIP1R, HIP12, KIAA0655
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related) (Hip 12).

MACOI_HUMAN
NC score	0.102121 (rank : 1428)	θ value	θ > 10 (rank : 1904)
Query Neighborhood Hits	1580	Target Neighborhood Hits	650	Shared Neighborhood Hits	250
SwissProt Accessions	Q8N5G2, Q2TLX5, Q2TLX6, Q9NVG6	Gene names	TMEM57
Domain Architecture	No domain graphic available
Description	Macoilin (Transmembrane protein 57).

CEAM1_HUMAN
NC score	0.102072 (rank : 1429)	θ value	θ > 10 (rank : 1673)
Query Neighborhood Hits	1580	Target Neighborhood Hits	348	Shared Neighborhood Hits	196
SwissProt Accessions	P13688, O60430, Q13858, Q15600, Q9UQV9	Gene names	CEACAM1, BGP, BGP1
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 1 precursor (Biliary glycoprotein 1) (BGP-1) (CD66 antigen) (CD66a antigen).

RFIP4_MOUSE
NC score	0.101868 (rank : 1430)	θ value	θ > 10 (rank : 2060)
Query Neighborhood Hits	1580	Target Neighborhood Hits	708	Shared Neighborhood Hits	276
SwissProt Accessions	Q8BQP8, Q80T87	Gene names	Rab11fip4, Kiaa1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

TACC2_HUMAN
NC score	0.101830 (rank : 1431)	θ value	θ > 10 (rank : 2144)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	315
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

LRRN5_HUMAN
NC score	0.101802 (rank : 1432)	θ value	9.92553e-07 (rank : 711)
Query Neighborhood Hits	1580	Target Neighborhood Hits	493	Shared Neighborhood Hits	216
SwissProt Accessions	O75325, Q5T0Y0, Q6UXM0, Q8N182	Gene names	LRRN5, GAC1, LRRN2
Domain Architecture
Description	Leucine-rich repeats neuronal protein 5 precursor (Glioma amplified on chromosome 1 protein).

TXLNG_MOUSE
NC score	0.101757 (rank : 1433)	θ value	θ > 10 (rank : 2182)
Query Neighborhood Hits	1580	Target Neighborhood Hits	552	Shared Neighborhood Hits	245
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

RFIP4_HUMAN
NC score	0.101452 (rank : 1434)	θ value	θ > 10 (rank : 2059)
Query Neighborhood Hits	1580	Target Neighborhood Hits	785	Shared Neighborhood Hits	288
SwissProt Accessions	Q86YS3, Q8N829, Q8NDT7, Q969D8	Gene names	RAB11FIP4, KIAA1821
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 4 (Rab11-FIP4).

AMOL2_HUMAN
NC score	0.101283 (rank : 1435)	θ value	θ > 10 (rank : 1600)
Query Neighborhood Hits	1580	Target Neighborhood Hits	603	Shared Neighborhood Hits	249
SwissProt Accessions	Q9Y2J4, Q53EP1, Q96F99, Q9UKB4	Gene names	AMOTL2, KIAA0989
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP).

CRCM_HUMAN
NC score	0.101218 (rank : 1436)	θ value	θ > 10 (rank : 1719)
Query Neighborhood Hits	1580	Target Neighborhood Hits	520	Shared Neighborhood Hits	230
SwissProt Accessions	P23508	Gene names	MCC
Domain Architecture
Description	Colorectal mutant cancer protein (Protein MCC).

GPA33_MOUSE
NC score	0.100689 (rank : 1437)	θ value	1.81305 (rank : 1327)
Query Neighborhood Hits	1580	Target Neighborhood Hits	294	Shared Neighborhood Hits	163
SwissProt Accessions	Q9JKA5, Q922D5	Gene names	Gpa33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33) (mA33).

CT2NL_MOUSE
NC score	0.100607 (rank : 1438)	θ value	θ > 10 (rank : 1731)
Query Neighborhood Hits	1580	Target Neighborhood Hits	902	Shared Neighborhood Hits	288
SwissProt Accessions	Q99LJ0, Q6ZPR0, Q8BSV1	Gene names	Cttnbp2nl, Kiaa1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

KINH_HUMAN
NC score	0.100551 (rank : 1439)	θ value	θ > 10 (rank : 1866)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1231	Shared Neighborhood Hits	347
SwissProt Accessions	P33176, Q5VZ85	Gene names	KIF5B, KNS, KNS1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

TXLNG_HUMAN
NC score	0.100534 (rank : 1440)	θ value	θ > 10 (rank : 2181)
Query Neighborhood Hits	1580	Target Neighborhood Hits	568	Shared Neighborhood Hits	242
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

DLG5_HUMAN
NC score	0.100334 (rank : 1441)	θ value	θ > 10 (rank : 1754)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1088	Shared Neighborhood Hits	328
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

LIPA3_HUMAN
NC score	0.099943 (rank : 1442)	θ value	θ > 10 (rank : 1882)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	295
SwissProt Accessions	O75145, Q9H8B5, Q9UEW4	Gene names	PPFIA3, KIAA0654
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

POF1B_HUMAN
NC score	0.099710 (rank : 1443)	θ value	θ > 10 (rank : 2025)
Query Neighborhood Hits	1580	Target Neighborhood Hits	494	Shared Neighborhood Hits	222
SwissProt Accessions	Q8WVV4, Q5H9E9, Q5H9F0, Q8NG12, Q9H5Y2, Q9H738, Q9H744	Gene names	POF1B
Domain Architecture	No domain graphic available
Description	Protein POF1B (Premature ovarian failure protein 1B).

P85B_MOUSE
NC score	0.099697 (rank : 1444)	θ value	θ > 10 (rank : 1988)
Query Neighborhood Hits	1580	Target Neighborhood Hits	519	Shared Neighborhood Hits	232
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CCD45_MOUSE
NC score	0.099575 (rank : 1445)	θ value	θ > 10 (rank : 1659)
Query Neighborhood Hits	1580	Target Neighborhood Hits	663	Shared Neighborhood Hits	238
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

FCRL2_HUMAN
NC score	0.099535 (rank : 1446)	θ value	θ > 10 (rank : 1773)
Query Neighborhood Hits	1580	Target Neighborhood Hits	251	Shared Neighborhood Hits	161
SwissProt Accessions	Q96LA5, Q6NTA1, Q9BZI4, Q9BZI5, Q9BZI6	Gene names	FCRL2, FCRH2, IFGP4, IRTA4, SPAP1
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 2 precursor (SH2 domain-containing phosphatase anchor protein 1) (Fc receptor homolog 2) (FcRH2) (Immunoglobulin receptor translocation-associated 4 protein).

TEX9_HUMAN
NC score	0.099513 (rank : 1447)	θ value	θ > 10 (rank : 2154)
Query Neighborhood Hits	1580	Target Neighborhood Hits	541	Shared Neighborhood Hits	241
SwissProt Accessions	Q8N6V9	Gene names	TEX9
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 9 protein.

TPM4_MOUSE
NC score	0.099353 (rank : 1448)	θ value	θ > 10 (rank : 2169)
Query Neighborhood Hits	1580	Target Neighborhood Hits	703	Shared Neighborhood Hits	267
SwissProt Accessions	Q6IRU2	Gene names	Tpm4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4).

PININ_HUMAN
NC score	0.099187 (rank : 1449)	θ value	θ > 10 (rank : 2011)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	261
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

MYO5B_HUMAN
NC score	0.099184 (rank : 1450)	θ value	θ > 10 (rank : 1945)
Query Neighborhood Hits	1580	Target Neighborhood Hits	911	Shared Neighborhood Hits	295
SwissProt Accessions	Q9ULV0	Gene names	MYO5B, KIAA1119
Domain Architecture
Description	Myosin-5B (Myosin Vb).

P85B_HUMAN
NC score	0.099183 (rank : 1451)	θ value	θ > 10 (rank : 1987)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	239
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

MAP1A_HUMAN
NC score	0.098845 (rank : 1452)	θ value	1.38821 (rank : 1310)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1626	Shared Neighborhood Hits	366
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

NEST_HUMAN
NC score	0.098727 (rank : 1453)	θ value	θ > 10 (rank : 1968)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1305	Shared Neighborhood Hits	337
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

CAR11_HUMAN
NC score	0.098499 (rank : 1454)	θ value	θ > 10 (rank : 1642)
Query Neighborhood Hits	1580	Target Neighborhood Hits	690	Shared Neighborhood Hits	268
SwissProt Accessions	Q9BXL7, Q548H3	Gene names	CARD11, CARMA1
Domain Architecture
Description	Caspase recruitment domain-containing protein 11 (CARD-containing MAGUK protein 3) (Carma 1).

HOME2_MOUSE
NC score	0.098287 (rank : 1455)	θ value	θ > 10 (rank : 1817)
Query Neighborhood Hits	1580	Target Neighborhood Hits	882	Shared Neighborhood Hits	292
SwissProt Accessions	Q9QWW1, O89025, Q9Z0E4	Gene names	Homer2, Vesl2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up- regulated during seizure and LTP 2) (Vesl-2).

AMOL2_MOUSE
NC score	0.097907 (rank : 1456)	θ value	θ > 10 (rank : 1601)
Query Neighborhood Hits	1580	Target Neighborhood Hits	591	Shared Neighborhood Hits	242
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

AL2SB_HUMAN
NC score	0.097766 (rank : 1457)	θ value	θ > 10 (rank : 1598)
Query Neighborhood Hits	1580	Target Neighborhood Hits	294	Shared Neighborhood Hits	163
SwissProt Accessions	Q96Q35	Gene names	ALS2CR12
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein.

TRAIP_MOUSE
NC score	0.097588 (rank : 1458)	θ value	θ > 10 (rank : 2171)
Query Neighborhood Hits	1580	Target Neighborhood Hits	745	Shared Neighborhood Hits	251
SwissProt Accessions	Q8VIG6, O08854, Q922M8, Q9CPP4	Gene names	Traip, Trip
Domain Architecture
Description	TRAF-interacting protein.

TPM4_HUMAN
NC score	0.097338 (rank : 1459)	θ value	θ > 10 (rank : 2168)
Query Neighborhood Hits	1580	Target Neighborhood Hits	525	Shared Neighborhood Hits	230
SwissProt Accessions	P67936, P07226, Q15659, Q9BU85, Q9H8Q3	Gene names	TPM4
Domain Architecture	No domain graphic available
Description	Tropomyosin alpha-4 chain (Tropomyosin-4) (TM30p1).

CCD42_HUMAN
NC score	0.097142 (rank : 1460)	θ value	θ > 10 (rank : 1656)
Query Neighborhood Hits	1580	Target Neighborhood Hits	406	Shared Neighborhood Hits	214
SwissProt Accessions	Q96M95, Q8N6Q0	Gene names	CCDC42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

AN30A_HUMAN
NC score	0.097053 (rank : 1461)	θ value	0.813845 (rank : 1249)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1119	Shared Neighborhood Hits	311
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

PPIP1_HUMAN
NC score	0.097051 (rank : 1462)	θ value	θ > 10 (rank : 2027)
Query Neighborhood Hits	1580	Target Neighborhood Hits	389	Shared Neighborhood Hits	194
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

RABE2_HUMAN
NC score	0.096959 (rank : 1463)	θ value	2.36792 (rank : 1366)
Query Neighborhood Hits	1580	Target Neighborhood Hits	545	Shared Neighborhood Hits	244
SwissProt Accessions	Q9H5N1	Gene names	RABEP2, RABPT5B
Domain Architecture
Description	Rab GTPase-binding effector protein 2 (Rabaptin-5beta).

KIF4A_HUMAN
NC score	0.096934 (rank : 1464)	θ value	1.06291 (rank : 1283)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1159	Shared Neighborhood Hits	331
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

CEP57_HUMAN
NC score	0.096899 (rank : 1465)	θ value	θ > 10 (rank : 1684)
Query Neighborhood Hits	1580	Target Neighborhood Hits	576	Shared Neighborhood Hits	257
SwissProt Accessions	Q86XR8, Q14704, Q8IXP0, Q9BVF9	Gene names	CEP57, KIAA0092, TSP57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin) (FGF2-interacting protein).

CD166_MOUSE
NC score	0.096897 (rank : 1466)	θ value	6.88961 (rank : 1480)
Query Neighborhood Hits	1580	Target Neighborhood Hits	252	Shared Neighborhood Hits	165
SwissProt Accessions	Q61490, O70136, Q8CDA5, Q8R2T0	Gene names	Alcam
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM) (DM-GRASP protein).

CTGE6_HUMAN
NC score	0.096820 (rank : 1467)	θ value	θ > 10 (rank : 1734)
Query Neighborhood Hits	1580	Target Neighborhood Hits	650	Shared Neighborhood Hits	256
SwissProt Accessions	Q86UF2	Gene names	CTAGE6
Domain Architecture	No domain graphic available
Description	Protein cTAGE-6 (cTAGE family member 6).

RAI14_MOUSE
NC score	0.096789 (rank : 1468)	θ value	θ > 10 (rank : 2046)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1505	Shared Neighborhood Hits	347
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

TRAIP_HUMAN
NC score	0.096731 (rank : 1469)	θ value	θ > 10 (rank : 2170)
Query Neighborhood Hits	1580	Target Neighborhood Hits	780	Shared Neighborhood Hits	266
SwissProt Accessions	Q9BWF2, O00467	Gene names	TRAIP, TRIP
Domain Architecture
Description	TRAF-interacting protein.

ASPP2_HUMAN
NC score	0.096654 (rank : 1470)	θ value	θ > 10 (rank : 1617)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1156	Shared Neighborhood Hits	362
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

SIGL5_MOUSE
NC score	0.096620 (rank : 1471)	θ value	0.279714 (rank : 1199)
Query Neighborhood Hits	1580	Target Neighborhood Hits	271	Shared Neighborhood Hits	197
SwissProt Accessions	Q920G3	Gene names	Siglec5, Siglecf
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Sialic acid-binding Ig-like lectin-F) (mSiglec-F).

INVO_MOUSE
NC score	0.096320 (rank : 1472)	θ value	θ > 10 (rank : 1837)
Query Neighborhood Hits	1580	Target Neighborhood Hits	474	Shared Neighborhood Hits	196
SwissProt Accessions	P48997	Gene names	Ivl
Domain Architecture	No domain graphic available
Description	Involucrin.

APOE_MOUSE
NC score	0.096295 (rank : 1473)	θ value	0.0563607 (rank : 1101)
Query Neighborhood Hits	1580	Target Neighborhood Hits	319	Shared Neighborhood Hits	162
SwissProt Accessions	P08226	Gene names	Apoe
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

LZTS1_MOUSE
NC score	0.096215 (rank : 1474)	θ value	θ > 10 (rank : 1901)
Query Neighborhood Hits	1580	Target Neighborhood Hits	540	Shared Neighborhood Hits	239
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

ZWINT_MOUSE
NC score	0.096180 (rank : 1475)	θ value	θ > 10 (rank : 2219)
Query Neighborhood Hits	1580	Target Neighborhood Hits	497	Shared Neighborhood Hits	229
SwissProt Accessions	Q9CQU5, Q3UYT8, Q91VI4, Q9D0W9	Gene names	Zwint, D10Ertd749e
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

CRKL_MOUSE
NC score	0.096125 (rank : 1476)	θ value	θ > 10 (rank : 1721)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	97
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.096108 (rank : 1477)	θ value	θ > 10 (rank : 1720)
Query Neighborhood Hits	1580	Target Neighborhood Hits	313	Shared Neighborhood Hits	99
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CCD93_MOUSE
NC score	0.095854 (rank : 1478)	θ value	θ > 10 (rank : 1661)
Query Neighborhood Hits	1580	Target Neighborhood Hits	362	Shared Neighborhood Hits	197
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CDR2_HUMAN
NC score	0.095833 (rank : 1479)	θ value	0.813845 (rank : 1253)
Query Neighborhood Hits	1580	Target Neighborhood Hits	404	Shared Neighborhood Hits	219
SwissProt Accessions	Q01850, Q13977	Gene names	CDR2, PCD17
Domain Architecture	No domain graphic available
Description	Cerebellar degeneration-related protein 2 (Paraneoplastic cerebellar degeneration-associated antigen) (Major Yo paraneoplastic antigen).

GPA33_HUMAN
NC score	0.095456 (rank : 1480)	θ value	3.0926 (rank : 1391)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	163
SwissProt Accessions	Q99795	Gene names	GPA33
Domain Architecture
Description	Cell surface A33 antigen precursor (Glycoprotein A33).

ADIP_HUMAN
NC score	0.095447 (rank : 1481)	θ value	θ > 10 (rank : 1595)
Query Neighborhood Hits	1580	Target Neighborhood Hits	470	Shared Neighborhood Hits	214
SwissProt Accessions	Q9Y2D8, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0	Gene names	SSX2IP, KIAA0923
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein) (SSX2-interacting protein).

APOA4_HUMAN
NC score	0.094953 (rank : 1482)	θ value	θ > 10 (rank : 1612)
Query Neighborhood Hits	1580	Target Neighborhood Hits	399	Shared Neighborhood Hits	193
SwissProt Accessions	P06727, Q6Q787	Gene names	APOA4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

RAI14_HUMAN
NC score	0.094911 (rank : 1483)	θ value	0.163984 (rank : 1166)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1367	Shared Neighborhood Hits	345
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

LRC4B_MOUSE
NC score	0.094211 (rank : 1484)	θ value	3.08544e-08 (rank : 615)
Query Neighborhood Hits	1580	Target Neighborhood Hits	484	Shared Neighborhood Hits	205
SwissProt Accessions	P0C192	Gene names	Lrrc4b, Lrig4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

AKAP6_HUMAN
NC score	0.094095 (rank : 1485)	θ value	1.38821 (rank : 1295)
Query Neighborhood Hits	1580	Target Neighborhood Hits	263	Shared Neighborhood Hits	124
SwissProt Accessions	Q13023, O15028	Gene names	AKAP6, AKAP100, KIAA0311
Domain Architecture
Description	A-kinase anchor protein 6 (Protein kinase A-anchoring protein 6) (PRKA6) (A-kinase anchor protein 100 kDa) (AKAP 100) (mAKAP).

P55G_HUMAN
NC score	0.094082 (rank : 1486)	θ value	θ > 10 (rank : 1983)
Query Neighborhood Hits	1580	Target Neighborhood Hits	451	Shared Neighborhood Hits	215
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

KINH_MOUSE
NC score	0.094073 (rank : 1487)	θ value	θ > 10 (rank : 1867)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1082	Shared Neighborhood Hits	339
SwissProt Accessions	Q61768, O08711, Q61580	Gene names	Kif5b, Khcs, Kns1
Domain Architecture
Description	Kinesin heavy chain (Ubiquitous kinesin heavy chain) (UKHC).

LRC4B_HUMAN
NC score	0.093862 (rank : 1488)	θ value	3.08544e-08 (rank : 614)
Query Neighborhood Hits	1580	Target Neighborhood Hits	479	Shared Neighborhood Hits	205
SwissProt Accessions	Q9NT99, Q3ZCQ4, Q58F20	Gene names	LRRC4B, LRIG4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4B precursor.

CF182_HUMAN
NC score	0.093790 (rank : 1489)	θ value	θ > 10 (rank : 1692)
Query Neighborhood Hits	1580	Target Neighborhood Hits	474	Shared Neighborhood Hits	226
SwissProt Accessions	Q8IYX8	Gene names	C6orf182
Domain Architecture	No domain graphic available
Description	Protein C6orf182.

APOA4_MOUSE
NC score	0.093560 (rank : 1490)	θ value	θ > 10 (rank : 1613)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	189
SwissProt Accessions	P06728	Gene names	Apoa4
Domain Architecture
Description	Apolipoprotein A-IV precursor (Apo-AIV) (ApoA-IV).

NDE1_MOUSE
NC score	0.093448 (rank : 1491)	θ value	θ > 10 (rank : 1960)
Query Neighborhood Hits	1580	Target Neighborhood Hits	602	Shared Neighborhood Hits	252
SwissProt Accessions	Q9CZA6, Q3UBS6, Q3UIC1, Q9ERR0	Gene names	Nde1, Nude
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE homolog 1 (NudE) (mNudE).

CCD45_HUMAN
NC score	0.093420 (rank : 1492)	θ value	θ > 10 (rank : 1658)
Query Neighborhood Hits	1580	Target Neighborhood Hits	525	Shared Neighborhood Hits	230
SwissProt Accessions	Q96GE4, Q96M81	Gene names	CCDC45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

HAP1_HUMAN
NC score	0.093326 (rank : 1493)	θ value	θ > 10 (rank : 1807)
Query Neighborhood Hits	1580	Target Neighborhood Hits	606	Shared Neighborhood Hits	254
SwissProt Accessions	P54257, O75358, Q9H4G3, Q9HA98, Q9NY90	Gene names	HAP1, HLP1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1) (Neuroan 1).

LIPB1_MOUSE
NC score	0.093141 (rank : 1494)	θ value	θ > 10 (rank : 1885)
Query Neighborhood Hits	1580	Target Neighborhood Hits	727	Shared Neighborhood Hits	281
SwissProt Accessions	Q8C8U0, Q69ZN5, Q6GQV3, Q80VB4, Q9CUT7	Gene names	Ppfibp1, Kiaa1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1).

P55G_MOUSE
NC score	0.093087 (rank : 1495)	θ value	θ > 10 (rank : 1984)
Query Neighborhood Hits	1580	Target Neighborhood Hits	401	Shared Neighborhood Hits	192
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

TCRG1_MOUSE
NC score	0.093067 (rank : 1496)	θ value	1.06291 (rank : 1293)
Query Neighborhood Hits	1580	Target Neighborhood Hits	947	Shared Neighborhood Hits	286
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

AMOL1_HUMAN
NC score	0.093020 (rank : 1497)	θ value	0.0961366 (rank : 1128)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	209
SwissProt Accessions	Q8IY63, Q63HK7, Q8NDN0, Q8WXD1, Q96CM5	Gene names	AMOTL1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

LZTS1_HUMAN
NC score	0.092961 (rank : 1498)	θ value	θ > 10 (rank : 1900)
Query Neighborhood Hits	1580	Target Neighborhood Hits	532	Shared Neighborhood Hits	229
SwissProt Accessions	Q9Y250, Q9Y5V7, Q9Y5V8, Q9Y5V9, Q9Y5W0, Q9Y5W1, Q9Y5W2	Gene names	LZTS1, FEZ1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

LIPB1_HUMAN
NC score	0.092858 (rank : 1499)	θ value	θ > 10 (rank : 1884)
Query Neighborhood Hits	1580	Target Neighborhood Hits	640	Shared Neighborhood Hits	260
SwissProt Accessions	Q86W92, O75336, Q86X70, Q9NY03, Q9ULJ0	Gene names	PPFIBP1, KIAA1230
Domain Architecture
Description	Liprin-beta-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1) (PTPRF-interacting protein-binding protein 1) (hSGT2).

PININ_MOUSE
NC score	0.092559 (rank : 1500)	θ value	θ > 10 (rank : 2012)
Query Neighborhood Hits	1580	Target Neighborhood Hits	777	Shared Neighborhood Hits	259
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

NPHP1_HUMAN
NC score	0.092532 (rank : 1501)	θ value	0.0330416 (rank : 1082)
Query Neighborhood Hits	1580	Target Neighborhood Hits	288	Shared Neighborhood Hits	132
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NGL1_MOUSE
NC score	0.092528 (rank : 1502)	θ value	1.38499e-08 (rank : 600)
Query Neighborhood Hits	1580	Target Neighborhood Hits	512	Shared Neighborhood Hits	208
SwissProt Accessions	Q8C031, Q8BGH8	Gene names	Lrrc4c, Ngl1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

NGL1_HUMAN
NC score	0.092522 (rank : 1503)	θ value	1.38499e-08 (rank : 599)
Query Neighborhood Hits	1580	Target Neighborhood Hits	511	Shared Neighborhood Hits	208
SwissProt Accessions	Q9HCJ2, Q7L0N3	Gene names	LRRC4C, KIAA1580, NGL1
Domain Architecture	No domain graphic available
Description	Netrin-G1 ligand precursor (NGL-1) (Leucine-rich repeat-containing protein 4C).

RUFY3_HUMAN
NC score	0.092286 (rank : 1504)	θ value	θ > 10 (rank : 2070)
Query Neighborhood Hits	1580	Target Neighborhood Hits	594	Shared Neighborhood Hits	251
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
NC score	0.092256 (rank : 1505)	θ value	θ > 10 (rank : 2071)
Query Neighborhood Hits	1580	Target Neighborhood Hits	579	Shared Neighborhood Hits	250
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

NRG1_HUMAN
NC score	0.092248 (rank : 1506)	θ value	1.38821 (rank : 1311)
Query Neighborhood Hits	1580	Target Neighborhood Hits	285	Shared Neighborhood Hits	154
SwissProt Accessions	Q02297, O14667, P98202, Q02298, Q02299, Q07110, Q07111, Q12779, Q12780, Q12781, Q12782, Q12783, Q12784, Q7RTV9, Q7RTW0, Q7RTW1, Q7RTW2, Q8NFN1, Q8NFN2, Q8NFN3, Q9UPE3	Gene names	NRG1, GGF, HGL, HRGA, NDF, SMDF
Domain Architecture
Description	Pro-neuregulin-1, membrane-bound isoform precursor (Pro-NRG1) [Contains: Neuregulin-1 (Neu differentiation factor) (Heregulin) (HRG) (Breast cancer cell differentiation factor p45) (Acetylcholine receptor-inducing activity) (ARIA) (Sensory and motor neuron-derived factor) (Glial growth factor)].

CIP4_HUMAN
NC score	0.092057 (rank : 1507)	θ value	θ > 10 (rank : 1702)
Query Neighborhood Hits	1580	Target Neighborhood Hits	374	Shared Neighborhood Hits	182
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

TCRG1_HUMAN
NC score	0.092032 (rank : 1508)	θ value	1.06291 (rank : 1292)
Query Neighborhood Hits	1580	Target Neighborhood Hits	929	Shared Neighborhood Hits	285
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

CEP57_MOUSE
NC score	0.092013 (rank : 1509)	θ value	θ > 10 (rank : 1685)
Query Neighborhood Hits	1580	Target Neighborhood Hits	580	Shared Neighborhood Hits	257
SwissProt Accessions	Q8CEE0, Q6ZQJ3, Q7TN18, Q80X65, Q810F2, Q9D4J4, Q9D5S4, Q9D5W5	Gene names	Cep57, Kiaa0092, Tsp57
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 57 kDa (Cep57 protein) (Testis-specific protein 57) (Translokin).

CENPJ_HUMAN
NC score	0.091520 (rank : 1510)	θ value	θ > 10 (rank : 1678)
Query Neighborhood Hits	1580	Target Neighborhood Hits	721	Shared Neighborhood Hits	271
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

MOES_MOUSE
NC score	0.091337 (rank : 1511)	θ value	0.0113563 (rank : 1036)
Query Neighborhood Hits	1580	Target Neighborhood Hits	923	Shared Neighborhood Hits	296
SwissProt Accessions	P26041, Q3UL28, Q8BSN4	Gene names	Msn
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

CENPH_HUMAN
NC score	0.090956 (rank : 1512)	θ value	θ > 10 (rank : 1676)
Query Neighborhood Hits	1580	Target Neighborhood Hits	335	Shared Neighborhood Hits	184
SwissProt Accessions	Q9H3R5	Gene names	CENPH, ICEN35
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H) (Interphase centromere complex protein 35).

SNX23_HUMAN
NC score	0.090869 (rank : 1513)	θ value	0.125558 (rank : 1152)
Query Neighborhood Hits	1580	Target Neighborhood Hits	944	Shared Neighborhood Hits	316
SwissProt Accessions	Q96L93, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9	Gene names	C20orf23, KIAA1590, SNX23
Domain Architecture
Description	Kinesin-like motor protein C20orf23 (Sorting nexin-23).

KIF5C_MOUSE
NC score	0.090765 (rank : 1514)	θ value	0.0431538 (rank : 1090)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1040	Shared Neighborhood Hits	327
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

ESAM_HUMAN
NC score	0.090311 (rank : 1515)	θ value	0.813845 (rank : 1255)
Query Neighborhood Hits	1580	Target Neighborhood Hits	251	Shared Neighborhood Hits	161
SwissProt Accessions	Q96AP7, Q96T50	Gene names	ESAM
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

CLC4F_HUMAN
NC score	0.090287 (rank : 1516)	θ value	θ > 10 (rank : 1706)
Query Neighborhood Hits	1580	Target Neighborhood Hits	513	Shared Neighborhood Hits	206
SwissProt Accessions	Q8N1N0	Gene names	CLEC4F, CLECSF13
Domain Architecture	No domain graphic available
Description	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13).

PPIP1_MOUSE
NC score	0.090155 (rank : 1517)	θ value	1.81305 (rank : 1337)
Query Neighborhood Hits	1580	Target Neighborhood Hits	377	Shared Neighborhood Hits	184
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

IF2P_HUMAN
NC score	0.090138 (rank : 1518)	θ value	θ > 10 (rank : 1824)
Query Neighborhood Hits	1580	Target Neighborhood Hits	889	Shared Neighborhood Hits	248
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

3BP5_HUMAN
NC score	0.090091 (rank : 1519)	θ value	θ > 10 (rank : 1581)
Query Neighborhood Hits	1580	Target Neighborhood Hits	375	Shared Neighborhood Hits	189
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

VDP_MOUSE
NC score	0.090004 (rank : 1520)	θ value	θ > 10 (rank : 2196)
Query Neighborhood Hits	1580	Target Neighborhood Hits	469	Shared Neighborhood Hits	223
SwissProt Accessions	Q9Z1Z0, Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5	Gene names	Vdp
Domain Architecture	No domain graphic available
Description	General vesicular transport factor p115 (Transcytosis-associated protein) (TAP) (Vesicle docking protein).

PHLB1_HUMAN
NC score	0.090001 (rank : 1521)	θ value	θ > 10 (rank : 2004)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1038	Shared Neighborhood Hits	330
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

MOES_HUMAN
NC score	0.089914 (rank : 1522)	θ value	0.0193708 (rank : 1061)
Query Neighborhood Hits	1580	Target Neighborhood Hits	892	Shared Neighborhood Hits	300
SwissProt Accessions	P26038	Gene names	MSN
Domain Architecture
Description	Moesin (Membrane-organizing extension spike protein).

KIF5C_HUMAN
NC score	0.089855 (rank : 1523)	θ value	0.00134147 (rank : 964)
Query Neighborhood Hits	1580	Target Neighborhood Hits	974	Shared Neighborhood Hits	317
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

CF152_MOUSE
NC score	0.089270 (rank : 1524)	θ value	θ > 10 (rank : 1691)
Query Neighborhood Hits	1580	Target Neighborhood Hits	597	Shared Neighborhood Hits	238
SwissProt Accessions	Q80ST9, Q9CYM9, Q9D5J9	Gene names
Domain Architecture	No domain graphic available
Description	Protein C6orf152 homolog.

CAF1A_MOUSE
NC score	0.089083 (rank : 1525)	θ value	θ > 10 (rank : 1638)
Query Neighborhood Hits	1580	Target Neighborhood Hits	736	Shared Neighborhood Hits	253
SwissProt Accessions	Q9QWF0	Gene names	Chaf1a, Caip150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

TACC3_MOUSE
NC score	0.088896 (rank : 1526)	θ value	1.81305 (rank : 1343)
Query Neighborhood Hits	1580	Target Neighborhood Hits	607	Shared Neighborhood Hits	235
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

CD166_HUMAN
NC score	0.088783 (rank : 1527)	θ value	θ > 10 (rank : 1668)
Query Neighborhood Hits	1580	Target Neighborhood Hits	247	Shared Neighborhood Hits	159
SwissProt Accessions	Q13740, O60892	Gene names	ALCAM, MEMD
Domain Architecture
Description	CD166 antigen precursor (Activated leukocyte-cell adhesion molecule) (ALCAM).

LRC24_HUMAN
NC score	0.088715 (rank : 1528)	θ value	0.0148317 (rank : 1048)
Query Neighborhood Hits	1580	Target Neighborhood Hits	404	Shared Neighborhood Hits	183
SwissProt Accessions	Q50LG9	Gene names	LRRC24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

CU013_HUMAN
NC score	0.088656 (rank : 1529)	θ value	θ > 10 (rank : 1736)
Query Neighborhood Hits	1580	Target Neighborhood Hits	405	Shared Neighborhood Hits	197
SwissProt Accessions	O95447	Gene names	C21orf13
Domain Architecture
Description	Protein C21orf13.

GP73_MOUSE
NC score	0.088551 (rank : 1530)	θ value	θ > 10 (rank : 1798)
Query Neighborhood Hits	1580	Target Neighborhood Hits	506	Shared Neighborhood Hits	211
SwissProt Accessions	Q91XA2	Gene names	Golph2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

AMOL1_MOUSE
NC score	0.088511 (rank : 1531)	θ value	0.0563607 (rank : 1100)
Query Neighborhood Hits	1580	Target Neighborhood Hits	445	Shared Neighborhood Hits	205
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

MYO10_HUMAN
NC score	0.088504 (rank : 1532)	θ value	5.27518 (rank : 1463)
Query Neighborhood Hits	1580	Target Neighborhood Hits	920	Shared Neighborhood Hits	289
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CRK_MOUSE
NC score	0.088276 (rank : 1533)	θ value	θ > 10 (rank : 1723)
Query Neighborhood Hits	1580	Target Neighborhood Hits	314	Shared Neighborhood Hits	100
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.088184 (rank : 1534)	θ value	θ > 10 (rank : 1722)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	100
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

MYO6_HUMAN
NC score	0.088170 (rank : 1535)	θ value	θ > 10 (rank : 1946)
Query Neighborhood Hits	1580	Target Neighborhood Hits	727	Shared Neighborhood Hits	263
SwissProt Accessions	Q9UM54, Q9BZZ7, Q9UEG2	Gene names	MYO6, KIAA0389
Domain Architecture
Description	Myosin-6 (Myosin VI).

IMMT_HUMAN
NC score	0.088169 (rank : 1536)	θ value	θ > 10 (rank : 1833)
Query Neighborhood Hits	1580	Target Neighborhood Hits	494	Shared Neighborhood Hits	218
SwissProt Accessions	Q16891, Q14539, Q15092, Q68D41, Q69HW5, Q6IBL0, Q7Z3X1, Q8TAJ5, Q9P0V2	Gene names	IMMT, HMP, PIG4
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin) (p87/89) (Proliferation-inducing gene 4 protein).

RASF8_HUMAN
NC score	0.088091 (rank : 1537)	θ value	θ > 10 (rank : 2050)
Query Neighborhood Hits	1580	Target Neighborhood Hits	469	Shared Neighborhood Hits	213
SwissProt Accessions	Q8NHQ8, O95647, Q5SCI2, Q76KB6	Gene names	RASSF8, C12orf2
Domain Architecture
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1).

ADIP_MOUSE
NC score	0.088068 (rank : 1538)	θ value	θ > 10 (rank : 1596)
Query Neighborhood Hits	1580	Target Neighborhood Hits	415	Shared Neighborhood Hits	200
SwissProt Accessions	Q8VC66, Q8BG59, Q8C7X0, Q8K2F7	Gene names	Ssx2ip
Domain Architecture	No domain graphic available
Description	Afadin- and alpha-actinin-binding protein (ADIP) (Afadin DIL domain- interacting protein).

SOS1_HUMAN
NC score	0.087381 (rank : 1539)	θ value	0.000461057 (rank : 928)
Query Neighborhood Hits	1580	Target Neighborhood Hits	274	Shared Neighborhood Hits	78
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

NEBL_HUMAN
NC score	0.087363 (rank : 1540)	θ value	θ > 10 (rank : 1966)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	202
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

MMRN2_HUMAN
NC score	0.087260 (rank : 1541)	θ value	θ > 10 (rank : 1924)
Query Neighborhood Hits	1580	Target Neighborhood Hits	400	Shared Neighborhood Hits	182
SwissProt Accessions	Q9H8L6, Q6P2N2	Gene names	MMRN2, EMILIN3
Domain Architecture
Description	Multimerin-2 precursor (EMILIN-3) (Elastin microfibril interface located protein 3) (Elastin microfibril interfacer 3) (EndoGlyx-1 p125/p140 subunit).

LIPA3_MOUSE
NC score	0.087223 (rank : 1542)	θ value	θ > 10 (rank : 1883)
Query Neighborhood Hits	1580	Target Neighborhood Hits	636	Shared Neighborhood Hits	263
SwissProt Accessions	P60469	Gene names	Ppfia3
Domain Architecture
Description	Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3).

3BP5_MOUSE
NC score	0.087142 (rank : 1543)	θ value	θ > 10 (rank : 1582)
Query Neighborhood Hits	1580	Target Neighborhood Hits	346	Shared Neighborhood Hits	177
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

KIF4A_MOUSE
NC score	0.087034 (rank : 1544)	θ value	θ > 10 (rank : 1860)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1033	Shared Neighborhood Hits	316
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

TACC2_MOUSE
NC score	0.086955 (rank : 1545)	θ value	θ > 10 (rank : 2145)
Query Neighborhood Hits	1580	Target Neighborhood Hits	774	Shared Neighborhood Hits	292
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

PDZD8_HUMAN
NC score	0.086906 (rank : 1546)	θ value	θ > 10 (rank : 1999)
Query Neighborhood Hits	1580	Target Neighborhood Hits	185	Shared Neighborhood Hits	63
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

MORC3_HUMAN
NC score	0.086873 (rank : 1547)	θ value	8.99809 (rank : 1548)
Query Neighborhood Hits	1580	Target Neighborhood Hits	489	Shared Neighborhood Hits	237
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

TRAK2_HUMAN
NC score	0.086816 (rank : 1548)	θ value	θ > 10 (rank : 2172)
Query Neighborhood Hits	1580	Target Neighborhood Hits	476	Shared Neighborhood Hits	229
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

PLCB4_HUMAN
NC score	0.086516 (rank : 1549)	θ value	θ > 10 (rank : 2019)
Query Neighborhood Hits	1580	Target Neighborhood Hits	658	Shared Neighborhood Hits	254
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

RBBP8_HUMAN
NC score	0.086407 (rank : 1550)	θ value	θ > 10 (rank : 2052)
Query Neighborhood Hits	1580	Target Neighborhood Hits	476	Shared Neighborhood Hits	215
SwissProt Accessions	Q99708, O75371	Gene names	RBBP8, CTIP
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 8 (RBBP-8) (CtBP-interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM).

SMOO_HUMAN
NC score	0.086283 (rank : 1551)	θ value	θ > 10 (rank : 2109)
Query Neighborhood Hits	1580	Target Neighborhood Hits	391	Shared Neighborhood Hits	108
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

WDR67_HUMAN
NC score	0.086259 (rank : 1552)	θ value	θ > 10 (rank : 2208)
Query Neighborhood Hits	1580	Target Neighborhood Hits	782	Shared Neighborhood Hits	260
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

ASPP1_MOUSE
NC score	0.086074 (rank : 1553)	θ value	5.27518 (rank : 1442)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1244	Shared Neighborhood Hits	353
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

UN13A_HUMAN
NC score	0.085953 (rank : 1554)	θ value	θ > 10 (rank : 2188)
Query Neighborhood Hits	1580	Target Neighborhood Hits	285	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

LRSM1_HUMAN
NC score	0.085798 (rank : 1555)	θ value	4.03905 (rank : 1433)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1078	Shared Neighborhood Hits	315
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

NEB2_MOUSE
NC score	0.085473 (rank : 1556)	θ value	θ > 10 (rank : 1965)
Query Neighborhood Hits	1580	Target Neighborhood Hits	889	Shared Neighborhood Hits	296
SwissProt Accessions	Q6R891, Q8K0X7	Gene names	Ppp1r9b
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

MILK2_HUMAN
NC score	0.085372 (rank : 1557)	θ value	θ > 10 (rank : 1921)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	148
SwissProt Accessions	Q8IY33, Q7RTP4, Q7Z655, Q8TEQ4, Q9H5F9	Gene names
Domain Architecture
Description	MICAL-like protein 2.

SOS1_MOUSE
NC score	0.085294 (rank : 1558)	θ value	0.00509761 (rank : 1008)
Query Neighborhood Hits	1580	Target Neighborhood Hits	281	Shared Neighborhood Hits	87
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

LIPB2_MOUSE
NC score	0.085130 (rank : 1559)	θ value	0.47712 (rank : 1228)
Query Neighborhood Hits	1580	Target Neighborhood Hits	570	Shared Neighborhood Hits	242
SwissProt Accessions	O35711, Q7TMG4, Q8CBS6, Q99KX6	Gene names	Ppfibp2, Cclp1
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2) (Coiled-coil-like protein 1).

CHIO_HUMAN
NC score	0.084978 (rank : 1560)	θ value	θ > 10 (rank : 1697)
Query Neighborhood Hits	1580	Target Neighborhood Hits	220	Shared Neighborhood Hits	75
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_MOUSE
NC score	0.084786 (rank : 1561)	θ value	θ > 10 (rank : 1696)
Query Neighborhood Hits	1580	Target Neighborhood Hits	229	Shared Neighborhood Hits	78
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

HC127_HUMAN
NC score	0.084784 (rank : 1562)	θ value	0.365318 (rank : 1206)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	157
SwissProt Accessions	Q9NQZ6, Q5JTF9, Q9H9C3, Q9H9H7, Q9ULQ4	Gene names	HCA127, KIAA1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127.

HC127_MOUSE
NC score	0.084784 (rank : 1563)	θ value	0.365318 (rank : 1207)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	157
SwissProt Accessions	Q68FG0, Q6ZPW6	Gene names	Hca127, Kiaa1166
Domain Architecture	No domain graphic available
Description	Hepatocellular carcinoma-associated antigen 127 homolog.

BUB1B_MOUSE
NC score	0.084755 (rank : 1564)	θ value	θ > 10 (rank : 1635)
Query Neighborhood Hits	1580	Target Neighborhood Hits	202	Shared Neighborhood Hits	125
SwissProt Accessions	Q9Z1S0	Gene names	Bub1b, Mad3l
Domain Architecture
Description	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (Mitotic checkpoint kinase MAD3L).

NCF1_HUMAN
NC score	0.084702 (rank : 1565)	θ value	θ > 10 (rank : 1954)
Query Neighborhood Hits	1580	Target Neighborhood Hits	198	Shared Neighborhood Hits	84
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

CLMN_HUMAN
NC score	0.084630 (rank : 1566)	θ value	3.0926 (rank : 1379)
Query Neighborhood Hits	1580	Target Neighborhood Hits	205	Shared Neighborhood Hits	50
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

SKIL_MOUSE
NC score	0.084621 (rank : 1567)	θ value	θ > 10 (rank : 2100)
Query Neighborhood Hits	1580	Target Neighborhood Hits	719	Shared Neighborhood Hits	279
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

DGKD_HUMAN
NC score	0.084591 (rank : 1568)	θ value	θ > 10 (rank : 1747)
Query Neighborhood Hits	1580	Target Neighborhood Hits	231	Shared Neighborhood Hits	106
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

TACC1_MOUSE
NC score	0.084554 (rank : 1569)	θ value	θ > 10 (rank : 2143)
Query Neighborhood Hits	1580	Target Neighborhood Hits	667	Shared Neighborhood Hits	262
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

CAF1A_HUMAN
NC score	0.084417 (rank : 1570)	θ value	θ > 10 (rank : 1637)
Query Neighborhood Hits	1580	Target Neighborhood Hits	750	Shared Neighborhood Hits	246
SwissProt Accessions	Q13111, Q7Z7K3, Q9UJY8	Gene names	CHAF1A, CAF, CAF1P150
Domain Architecture	No domain graphic available
Description	Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-Ip150).

LZTS2_HUMAN
NC score	0.084393 (rank : 1571)	θ value	θ > 10 (rank : 1902)
Query Neighborhood Hits	1580	Target Neighborhood Hits	427	Shared Neighborhood Hits	207
SwissProt Accessions	Q9BRK4, Q8N3I0, Q96J79, Q96JL2	Gene names	LZTS2, KIAA1813, LAPSER1
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2 (Protein LAPSER1).

CEP35_HUMAN
NC score	0.084374 (rank : 1572)	θ value	θ > 10 (rank : 1681)
Query Neighborhood Hits	1580	Target Neighborhood Hits	811	Shared Neighborhood Hits	263
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

SOS2_HUMAN
NC score	0.084365 (rank : 1573)	θ value	0.00035302 (rank : 918)
Query Neighborhood Hits	1580	Target Neighborhood Hits	193	Shared Neighborhood Hits	65
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

MFAP1_MOUSE
NC score	0.084250 (rank : 1574)	θ value	θ > 10 (rank : 1914)
Query Neighborhood Hits	1580	Target Neighborhood Hits	353	Shared Neighborhood Hits	159
SwissProt Accessions	Q9CQU1, Q3TU29, Q8CCL1, Q9CSJ5	Gene names	Mfap1
Domain Architecture	No domain graphic available
Description	Microfibrillar-associated protein 1.

MYO6_MOUSE
NC score	0.084153 (rank : 1575)	θ value	θ > 10 (rank : 1947)
Query Neighborhood Hits	1580	Target Neighborhood Hits	586	Shared Neighborhood Hits	229
SwissProt Accessions	Q64331	Gene names	Myo6, Sv
Domain Architecture
Description	Myosin-6 (Myosin VI).

CHIN_HUMAN
NC score	0.083960 (rank : 1576)	θ value	θ > 10 (rank : 1695)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	77
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

LBN_HUMAN
NC score	0.083945 (rank : 1577)	θ value	θ > 10 (rank : 1879)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	181
SwissProt Accessions	Q86UK5, Q86YT3, Q86YT4, Q8NG49	Gene names	EVC2, LBN
Domain Architecture	No domain graphic available
Description	Limbin.

PGFRL_HUMAN
NC score	0.083924 (rank : 1578)	θ value	3.0926 (rank : 1397)
Query Neighborhood Hits	1580	Target Neighborhood Hits	115	Shared Neighborhood Hits	106
SwissProt Accessions	Q15198, Q6FH04	Gene names	PDGFRL, PRLTS
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor (PDGF receptor beta-like tumor suppressor).

TACC1_HUMAN
NC score	0.083746 (rank : 1579)	θ value	θ > 10 (rank : 2142)
Query Neighborhood Hits	1580	Target Neighborhood Hits	597	Shared Neighborhood Hits	248
SwissProt Accessions	O75410, Q6Y687, Q86YG7, Q8IUJ2, Q8IUJ3, Q8IUJ4, Q8IZG2, Q8NEY7, Q9UPP9	Gene names	TACC1, KIAA1103
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 1 (Taxin 1) (Gastric cancer antigen Ga55).

TEKT1_MOUSE
NC score	0.083681 (rank : 1580)	θ value	θ > 10 (rank : 2153)
Query Neighborhood Hits	1580	Target Neighborhood Hits	399	Shared Neighborhood Hits	190
SwissProt Accessions	Q9DAJ2	Gene names	Tekt1
Domain Architecture
Description	Tektin-1.

PLCG1_MOUSE
NC score	0.083676 (rank : 1581)	θ value	θ > 10 (rank : 2021)
Query Neighborhood Hits	1580	Target Neighborhood Hits	314	Shared Neighborhood Hits	106
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RPGR1_MOUSE
NC score	0.083563 (rank : 1582)	θ value	6.88961 (rank : 1511)
Query Neighborhood Hits	1580	Target Neighborhood Hits	713	Shared Neighborhood Hits	245
SwissProt Accessions	Q9EPQ2, Q8CAC2, Q8CDJ9, Q91WE0, Q9CUK6, Q9D5Q1	Gene names	Rpgrip1
Domain Architecture	No domain graphic available
Description	X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1).

TARA_MOUSE
NC score	0.083500 (rank : 1583)	θ value	8.99809 (rank : 1570)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1133	Shared Neighborhood Hits	331
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CEAM6_HUMAN
NC score	0.083435 (rank : 1584)	θ value	θ > 10 (rank : 1674)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	198
SwissProt Accessions	P40199, Q14920	Gene names	CEACAM6, NCA
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 6 precursor (Normal cross-reacting antigen) (Nonspecific crossreacting antigen) (CD66c antigen).

CLMN_MOUSE
NC score	0.083365 (rank : 1585)	θ value	θ > 10 (rank : 1708)
Query Neighborhood Hits	1580	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q8C5W0, Q91V71, Q91XT7, Q91XT8, Q91XU9	Gene names	Clmn
Domain Architecture
Description	Calmin.

MRIP_HUMAN
NC score	0.083073 (rank : 1586)	θ value	θ > 10 (rank : 1927)
Query Neighborhood Hits	1580	Target Neighborhood Hits	578	Shared Neighborhood Hits	232
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

REN3B_HUMAN
NC score	0.083017 (rank : 1587)	θ value	θ > 10 (rank : 2057)
Query Neighborhood Hits	1580	Target Neighborhood Hits	412	Shared Neighborhood Hits	165
SwissProt Accessions	Q9BZI7, Q9H1J0	Gene names	UPF3B, RENT3B, UPF3X
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (hUpf3p-X).

MRIP_MOUSE
NC score	0.082976 (rank : 1588)	θ value	θ > 10 (rank : 1928)
Query Neighborhood Hits	1580	Target Neighborhood Hits	569	Shared Neighborhood Hits	231
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

K0552_HUMAN
NC score	0.082856 (rank : 1589)	θ value	θ > 10 (rank : 1851)
Query Neighborhood Hits	1580	Target Neighborhood Hits	442	Shared Neighborhood Hits	203
SwissProt Accessions	O60299	Gene names	KIAA0552
Domain Architecture
Description	Protein KIAA0552.

SEC20_MOUSE
NC score	0.082839 (rank : 1590)	θ value	0.279714 (rank : 1197)
Query Neighborhood Hits	1580	Target Neighborhood Hits	323	Shared Neighborhood Hits	177
SwissProt Accessions	Q6QD59, Q5M9M2	Gene names	Bnip1, Sec20, Sec20l
Domain Architecture	No domain graphic available
Description	Vesicle transport protein SEC20.

LIPB2_HUMAN
NC score	0.082828 (rank : 1591)	θ value	1.81305 (rank : 1333)
Query Neighborhood Hits	1580	Target Neighborhood Hits	599	Shared Neighborhood Hits	246
SwissProt Accessions	Q8ND30, O75337, Q8WW26	Gene names	PPFIBP2
Domain Architecture
Description	Liprin-beta-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 2) (PTPRF-interacting protein-binding protein 2).

RASF8_MOUSE
NC score	0.082813 (rank : 1592)	θ value	θ > 10 (rank : 2051)
Query Neighborhood Hits	1580	Target Neighborhood Hits	391	Shared Neighborhood Hits	188
SwissProt Accessions	Q8CJ96, Q8CCW4, Q9CU91	Gene names	Rassf8
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1 homolog).

ENAH_HUMAN
NC score	0.082803 (rank : 1593)	θ value	θ > 10 (rank : 1762)
Query Neighborhood Hits	1580	Target Neighborhood Hits	784	Shared Neighborhood Hits	272
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

STIM1_HUMAN
NC score	0.082787 (rank : 1594)	θ value	8.99809 (rank : 1568)
Query Neighborhood Hits	1580	Target Neighborhood Hits	665	Shared Neighborhood Hits	256
SwissProt Accessions	Q13586	Gene names	STIM1, GOK
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

HOME1_MOUSE
NC score	0.082776 (rank : 1595)	θ value	θ > 10 (rank : 1815)
Query Neighborhood Hits	1580	Target Neighborhood Hits	630	Shared Neighborhood Hits	246
SwissProt Accessions	Q9Z2Y3, Q8K3E1, Q8K4M8, Q9Z0E9, Q9Z216	Gene names	Homer1, Vesl1
Domain Architecture
Description	Homer protein homolog 1 (VASP/Ena-related gene up-regulated during seizure and LTP) (Vesl-1).

PHLB3_HUMAN
NC score	0.082774 (rank : 1596)	θ value	θ > 10 (rank : 2006)
Query Neighborhood Hits	1580	Target Neighborhood Hits	304	Shared Neighborhood Hits	165
SwissProt Accessions	Q6NSJ2, Q8N7Z4	Gene names	PHLDB3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 3.

LRRC4_HUMAN
NC score	0.082583 (rank : 1597)	θ value	0.00102713 (rank : 957)
Query Neighborhood Hits	1580	Target Neighborhood Hits	444	Shared Neighborhood Hits	180
SwissProt Accessions	Q9HBW1, Q6ZMI8, Q96A85	Gene names	LRRC4, BAG
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 4 precursor (Brain tumor- associated protein LRRC4) (NAG14).

SH24A_HUMAN
NC score	0.082569 (rank : 1598)	θ value	θ > 10 (rank : 2081)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	184
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

PLCG1_HUMAN
NC score	0.082515 (rank : 1599)	θ value	θ > 10 (rank : 2020)
Query Neighborhood Hits	1580	Target Neighborhood Hits	293	Shared Neighborhood Hits	103
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NEB2_HUMAN
NC score	0.082382 (rank : 1600)	θ value	θ > 10 (rank : 1964)
Query Neighborhood Hits	1580	Target Neighborhood Hits	883	Shared Neighborhood Hits	290
SwissProt Accessions	Q96SB3, Q8TCR9	Gene names	PPP1R9B
Domain Architecture	No domain graphic available
Description	Neurabin-2 (Neurabin-II) (Spinophilin) (Protein phosphatase 1 regulatory subunit 9B).

ESAM_MOUSE
NC score	0.082252 (rank : 1601)	θ value	0.365318 (rank : 1205)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	150
SwissProt Accessions	Q925F2	Gene names	Esam, Esam1
Domain Architecture	No domain graphic available
Description	Endothelial cell-selective adhesion molecule precursor.

PLVAP_HUMAN
NC score	0.082221 (rank : 1602)	θ value	θ > 10 (rank : 2023)
Query Neighborhood Hits	1580	Target Neighborhood Hits	397	Shared Neighborhood Hits	195
SwissProt Accessions	Q9BX97, Q86VP0, Q8N8Y0, Q8ND68, Q8TER8, Q9BZD5	Gene names	PLVAP, FELS, PV1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (Fenestrated endothelial-linked structure protein).

CAR10_HUMAN
NC score	0.082062 (rank : 1603)	θ value	θ > 10 (rank : 1640)
Query Neighborhood Hits	1580	Target Neighborhood Hits	569	Shared Neighborhood Hits	246
SwissProt Accessions	Q9BWT7, Q14CQ8, Q5TFG6, Q9UGR5, Q9UGR6, Q9Y3H0	Gene names	CARD10, CARMA3
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (CARD-containing MAGUK protein 3) (Carma 3).

TACC3_HUMAN
NC score	0.081886 (rank : 1604)	θ value	θ > 10 (rank : 2146)
Query Neighborhood Hits	1580	Target Neighborhood Hits	779	Shared Neighborhood Hits	271
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

ASPP1_HUMAN
NC score	0.081817 (rank : 1605)	θ value	θ > 10 (rank : 1616)
Query Neighborhood Hits	1580	Target Neighborhood Hits	956	Shared Neighborhood Hits	320
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

LETM1_HUMAN
NC score	0.081736 (rank : 1606)	θ value	3.0926 (rank : 1394)
Query Neighborhood Hits	1580	Target Neighborhood Hits	338	Shared Neighborhood Hits	184
SwissProt Accessions	O95202, Q9UF65	Gene names	LETM1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

UN13B_HUMAN
NC score	0.081447 (rank : 1607)	θ value	θ > 10 (rank : 2189)
Query Neighborhood Hits	1580	Target Neighborhood Hits	217	Shared Neighborhood Hits	62
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

TTC3_HUMAN
NC score	0.081258 (rank : 1608)	θ value	0.279714 (rank : 1201)
Query Neighborhood Hits	1580	Target Neighborhood Hits	664	Shared Neighborhood Hits	228
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

HOME2_HUMAN
NC score	0.081041 (rank : 1609)	θ value	θ > 10 (rank : 1816)
Query Neighborhood Hits	1580	Target Neighborhood Hits	532	Shared Neighborhood Hits	230
SwissProt Accessions	Q9NSB8, O95269, O95349, Q9NSB6, Q9NSB7, Q9UNT7	Gene names	HOMER2
Domain Architecture
Description	Homer protein homolog 2 (Homer-2) (Cupidin).

COVA1_HUMAN
NC score	0.080813 (rank : 1610)	θ value	θ > 10 (rank : 1718)
Query Neighborhood Hits	1580	Target Neighborhood Hits	416	Shared Neighborhood Hits	193
SwissProt Accessions	Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82	Gene names	COVA1
Domain Architecture
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

SIGL8_HUMAN
NC score	0.080803 (rank : 1611)	θ value	6.88961 (rank : 1514)
Query Neighborhood Hits	1580	Target Neighborhood Hits	252	Shared Neighborhood Hits	188
SwissProt Accessions	Q9NYZ4, Q7Z728	Gene names	SIGLEC8, SAF2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 8 precursor (Siglec-8) (Sialoadhesin family member 2) (SAF-2) (CDw329 antigen).

JIP3_MOUSE
NC score	0.080645 (rank : 1612)	θ value	θ > 10 (rank : 1846)
Query Neighborhood Hits	1580	Target Neighborhood Hits	759	Shared Neighborhood Hits	293
SwissProt Accessions	Q9ESN9, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7	Gene names	Mapk8ip3, Jip3, Jsap1, Syd2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3) (JNK/SAPK-associated protein 1) (JSAP1) (Sunday driver 2).

STIM1_MOUSE
NC score	0.080192 (rank : 1613)	θ value	θ > 10 (rank : 2128)
Query Neighborhood Hits	1580	Target Neighborhood Hits	660	Shared Neighborhood Hits	255
SwissProt Accessions	P70302	Gene names	Stim1, Sim
Domain Architecture
Description	Stromal interaction molecule 1 precursor.

RASF1_MOUSE
NC score	0.080166 (rank : 1614)	θ value	θ > 10 (rank : 2049)
Query Neighborhood Hits	1580	Target Neighborhood Hits	74	Shared Neighborhood Hits	35
SwissProt Accessions	Q99MK9, Q9WUF5	Gene names	Rassf1
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1 (Protein 123F2).

NCF1_MOUSE
NC score	0.079923 (rank : 1615)	θ value	θ > 10 (rank : 1955)
Query Neighborhood Hits	1580	Target Neighborhood Hits	198	Shared Neighborhood Hits	83
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

TARA_HUMAN
NC score	0.079826 (rank : 1616)	θ value	0.813845 (rank : 1267)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1626	Shared Neighborhood Hits	390
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

DGKH_HUMAN
NC score	0.079414 (rank : 1617)	θ value	θ > 10 (rank : 1750)
Query Neighborhood Hits	1580	Target Neighborhood Hits	255	Shared Neighborhood Hits	90
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

LZTS2_MOUSE
NC score	0.079236 (rank : 1618)	θ value	θ > 10 (rank : 1903)
Query Neighborhood Hits	1580	Target Neighborhood Hits	423	Shared Neighborhood Hits	195
SwissProt Accessions	Q91YU6, Q569X6	Gene names	Lzts2, Kiaa1813
Domain Architecture
Description	Leucine zipper putative tumor suppressor 2.

CD2AP_HUMAN
NC score	0.079169 (rank : 1619)	θ value	θ > 10 (rank : 1670)
Query Neighborhood Hits	1580	Target Neighborhood Hits	315	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

LRC24_MOUSE
NC score	0.079121 (rank : 1620)	θ value	0.813845 (rank : 1260)
Query Neighborhood Hits	1580	Target Neighborhood Hits	387	Shared Neighborhood Hits	180
SwissProt Accessions	Q8BHA1	Gene names	Lrrc24
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 24 precursor.

CD2AP_MOUSE
NC score	0.078995 (rank : 1621)	θ value	8.99809 (rank : 1530)
Query Neighborhood Hits	1580	Target Neighborhood Hits	336	Shared Neighborhood Hits	130
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

UN13B_MOUSE
NC score	0.078979 (rank : 1622)	θ value	θ > 10 (rank : 2190)
Query Neighborhood Hits	1580	Target Neighborhood Hits	210	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

SPC24_HUMAN
NC score	0.078906 (rank : 1623)	θ value	θ > 10 (rank : 2111)
Query Neighborhood Hits	1580	Target Neighborhood Hits	324	Shared Neighborhood Hits	168
SwissProt Accessions	Q8NBT2	Gene names	SPBC24
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc24 (hSpc24).

LMNB1_HUMAN
NC score	0.078862 (rank : 1624)	θ value	0.125558 (rank : 1148)
Query Neighborhood Hits	1580	Target Neighborhood Hits	714	Shared Neighborhood Hits	275
SwissProt Accessions	P20700, Q3SYN7, Q96EI6	Gene names	LMNB1, LMN2, LMNB
Domain Architecture
Description	Lamin-B1.

SRBS1_HUMAN
NC score	0.078711 (rank : 1625)	θ value	0.365318 (rank : 1217)
Query Neighborhood Hits	1580	Target Neighborhood Hits	396	Shared Neighborhood Hits	131
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

LMNB1_MOUSE
NC score	0.078594 (rank : 1626)	θ value	0.0193708 (rank : 1060)
Query Neighborhood Hits	1580	Target Neighborhood Hits	719	Shared Neighborhood Hits	271
SwissProt Accessions	P14733, Q61791	Gene names	Lmnb1
Domain Architecture
Description	Lamin-B1.

CAR14_MOUSE
NC score	0.078556 (rank : 1627)	θ value	θ > 10 (rank : 1644)
Query Neighborhood Hits	1580	Target Neighborhood Hits	526	Shared Neighborhood Hits	227
SwissProt Accessions	Q99KF0	Gene names	Card14, Bimp2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (Bcl10-interacting MAGUK protein 2) (Bimp2).

CCD42_MOUSE
NC score	0.078338 (rank : 1628)	θ value	θ > 10 (rank : 1657)
Query Neighborhood Hits	1580	Target Neighborhood Hits	284	Shared Neighborhood Hits	171
SwissProt Accessions	Q5SV66, Q8BNY1	Gene names	Ccdc42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

MYO1F_HUMAN
NC score	0.078211 (rank : 1629)	θ value	θ > 10 (rank : 1941)
Query Neighborhood Hits	1580	Target Neighborhood Hits	275	Shared Neighborhood Hits	122
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

STXB4_HUMAN
NC score	0.078119 (rank : 1630)	θ value	θ > 10 (rank : 2134)
Query Neighborhood Hits	1580	Target Neighborhood Hits	616	Shared Neighborhood Hits	222
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

MYO1E_HUMAN
NC score	0.078105 (rank : 1631)	θ value	θ > 10 (rank : 1940)
Query Neighborhood Hits	1580	Target Neighborhood Hits	293	Shared Neighborhood Hits	122
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MILK1_HUMAN
NC score	0.078087 (rank : 1632)	θ value	θ > 10 (rank : 1920)
Query Neighborhood Hits	1580	Target Neighborhood Hits	427	Shared Neighborhood Hits	120
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SH3K1_HUMAN
NC score	0.078080 (rank : 1633)	θ value	θ > 10 (rank : 2088)
Query Neighborhood Hits	1580	Target Neighborhood Hits	341	Shared Neighborhood Hits	134
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

K0586_HUMAN
NC score	0.077925 (rank : 1634)	θ value	θ > 10 (rank : 1852)
Query Neighborhood Hits	1580	Target Neighborhood Hits	311	Shared Neighborhood Hits	149
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

SH21B_MOUSE
NC score	0.077905 (rank : 1635)	θ value	θ > 10 (rank : 2080)
Query Neighborhood Hits	1580	Target Neighborhood Hits	101	Shared Neighborhood Hits	44
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

HOME1_HUMAN
NC score	0.077738 (rank : 1636)	θ value	θ > 10 (rank : 1814)
Query Neighborhood Hits	1580	Target Neighborhood Hits	564	Shared Neighborhood Hits	230
SwissProt Accessions	Q86YM7, O96003, Q86YM5	Gene names	HOMER1, SYN47
Domain Architecture
Description	Homer protein homolog 1.

PLCG2_HUMAN
NC score	0.077690 (rank : 1637)	θ value	θ > 10 (rank : 2022)
Query Neighborhood Hits	1580	Target Neighborhood Hits	280	Shared Neighborhood Hits	90
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

MYO1F_MOUSE
NC score	0.077669 (rank : 1638)	θ value	θ > 10 (rank : 1942)
Query Neighborhood Hits	1580	Target Neighborhood Hits	262	Shared Neighborhood Hits	114
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NDEL1_HUMAN
NC score	0.077658 (rank : 1639)	θ value	θ > 10 (rank : 1961)
Query Neighborhood Hits	1580	Target Neighborhood Hits	415	Shared Neighborhood Hits	202
SwissProt Accessions	Q9GZM8, Q86T80, Q8TAR7, Q9UH50	Gene names	NDEL1, EOPA, MITAP1, NUDEL
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin- associated protein 1).

NDEL1_MOUSE
NC score	0.077169 (rank : 1640)	θ value	θ > 10 (rank : 1962)
Query Neighborhood Hits	1580	Target Neighborhood Hits	420	Shared Neighborhood Hits	203
SwissProt Accessions	Q9ERR1, Q9D0Q4, Q9EPT6	Gene names	Ndel1, Nudel
Domain Architecture	No domain graphic available
Description	Nuclear distribution protein nudE-like 1 (Protein Nudel) (Protein mNudE-like) (mNudE-L).

KIF5A_HUMAN
NC score	0.077088 (rank : 1641)	θ value	θ > 10 (rank : 1861)
Query Neighborhood Hits	1580	Target Neighborhood Hits	843	Shared Neighborhood Hits	297
SwissProt Accessions	Q12840, Q4LE26	Gene names	KIF5A, NKHC1
Domain Architecture
Description	Kinesin heavy chain isoform 5A (Neuronal kinesin heavy chain) (NKHC) (Kinesin heavy chain neuron-specific 1).

LBN_MOUSE
NC score	0.076889 (rank : 1642)	θ value	θ > 10 (rank : 1880)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K1G2, Q8BRF3	Gene names	Evc2, Lbn
Domain Architecture	No domain graphic available
Description	Limbin.

GLE1_MOUSE
NC score	0.076728 (rank : 1643)	θ value	θ > 10 (rank : 1793)
Query Neighborhood Hits	1580	Target Neighborhood Hits	504	Shared Neighborhood Hits	204
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

KIF5A_MOUSE
NC score	0.076622 (rank : 1644)	θ value	θ > 10 (rank : 1862)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	301
SwissProt Accessions	P33175, Q5DTP1, Q6PDY7, Q9Z2F9	Gene names	Kif5a, Kiaa4086, Kif5, Nkhc1
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5A (Neuronal kinesin heavy chain) (NKHC) (Kinesin heavy chain neuron-specific 1).

TEKT1_HUMAN
NC score	0.076599 (rank : 1645)	θ value	θ > 10 (rank : 2152)
Query Neighborhood Hits	1580	Target Neighborhood Hits	289	Shared Neighborhood Hits	173
SwissProt Accessions	Q969V4	Gene names	TEKT1
Domain Architecture
Description	Tektin-1.

MILK1_MOUSE
NC score	0.076572 (rank : 1646)	θ value	2.36792 (rank : 1362)
Query Neighborhood Hits	1580	Target Neighborhood Hits	788	Shared Neighborhood Hits	144
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

TNNT2_HUMAN
NC score	0.076566 (rank : 1647)	θ value	θ > 10 (rank : 2160)
Query Neighborhood Hits	1580	Target Neighborhood Hits	433	Shared Neighborhood Hits	183
SwissProt Accessions	P45379, O60214, Q99596, Q99597, Q9UM96	Gene names	TNNT2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

MAP9_MOUSE
NC score	0.076564 (rank : 1648)	θ value	θ > 10 (rank : 1909)
Query Neighborhood Hits	1580	Target Neighborhood Hits	529	Shared Neighborhood Hits	206
SwissProt Accessions	Q3TRR0, Q3UUD1, Q3UX85, Q3UXE7, Q5M8N8, Q6P8K1, Q8BMM4, Q8BYP7	Gene names	Map9, Asap
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

ZC313_HUMAN
NC score	0.076516 (rank : 1649)	θ value	θ > 10 (rank : 2214)
Query Neighborhood Hits	1580	Target Neighborhood Hits	772	Shared Neighborhood Hits	213
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

CILP2_HUMAN
NC score	0.075989 (rank : 1650)	θ value	θ > 10 (rank : 1701)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	160
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

GP73_HUMAN
NC score	0.075855 (rank : 1651)	θ value	θ > 10 (rank : 1797)
Query Neighborhood Hits	1580	Target Neighborhood Hits	309	Shared Neighborhood Hits	163
SwissProt Accessions	Q8NBJ4, Q6IAF4, Q9NRB9	Gene names	GOLPH2
Domain Architecture	No domain graphic available
Description	Golgi phosphoprotein 2 (Golgi membrane protein GP73).

SIG12_HUMAN
NC score	0.075850 (rank : 1652)	θ value	1.38821 (rank : 1317)
Query Neighborhood Hits	1580	Target Neighborhood Hits	245	Shared Neighborhood Hits	186
SwissProt Accessions	Q96PQ1, Q8IYH7	Gene names	SIGLEC12, SIGLECL1, SLG
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 12 precursor (Siglec-12) (Sialic acid-binding Ig-like lectin-like 1) (Siglec-L1).

VINEX_MOUSE
NC score	0.075675 (rank : 1653)	θ value	θ > 10 (rank : 2200)
Query Neighborhood Hits	1580	Target Neighborhood Hits	286	Shared Neighborhood Hits	103
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

P85A_HUMAN
NC score	0.075526 (rank : 1654)	θ value	θ > 10 (rank : 1985)
Query Neighborhood Hits	1580	Target Neighborhood Hits	479	Shared Neighborhood Hits	198
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

LRSM1_MOUSE
NC score	0.075444 (rank : 1655)	θ value	1.38821 (rank : 1309)
Query Neighborhood Hits	1580	Target Neighborhood Hits	874	Shared Neighborhood Hits	276
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

SH3K1_MOUSE
NC score	0.075403 (rank : 1656)	θ value	θ > 10 (rank : 2089)
Query Neighborhood Hits	1580	Target Neighborhood Hits	332	Shared Neighborhood Hits	133
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

MAP9_HUMAN
NC score	0.075195 (rank : 1657)	θ value	θ > 10 (rank : 1908)
Query Neighborhood Hits	1580	Target Neighborhood Hits	518	Shared Neighborhood Hits	189
SwissProt Accessions	Q49MG5, Q4W5I7, Q68DU1, Q9H781, Q9H7B6	Gene names	MAP9, ASAP
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 9 (Aster-associated protein).

JIP3_HUMAN
NC score	0.075090 (rank : 1658)	θ value	θ > 10 (rank : 1845)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1039	Shared Neighborhood Hits	311
SwissProt Accessions	Q9UPT6, Q96RY4, Q9H4I4, Q9H7P1, Q9NUG0	Gene names	MAPK8IP3, JIP3, KIAA1066
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 3 (JNK-interacting protein 3) (JIP-3) (JNK MAP kinase scaffold protein 3) (Mitogen- activated protein kinase 8-interacting protein 3).

PRC1_HUMAN
NC score	0.075059 (rank : 1659)	θ value	θ > 10 (rank : 2029)
Query Neighborhood Hits	1580	Target Neighborhood Hits	328	Shared Neighborhood Hits	171
SwissProt Accessions	O43663, Q9BSB6	Gene names	PRC1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

DZIP1_MOUSE
NC score	0.075041 (rank : 1660)	θ value	0.00869519 (rank : 1026)
Query Neighborhood Hits	1580	Target Neighborhood Hits	530	Shared Neighborhood Hits	173
SwissProt Accessions	Q8BMD2, Q6ZQ10, Q9CRK5	Gene names	Dzip1, Kiaa0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1 homolog).

CHIO_MOUSE
NC score	0.074998 (rank : 1661)	θ value	θ > 10 (rank : 1698)
Query Neighborhood Hits	1580	Target Neighborhood Hits	130	Shared Neighborhood Hits	46
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

SIGL5_HUMAN
NC score	0.074966 (rank : 1662)	θ value	θ > 10 (rank : 2096)
Query Neighborhood Hits	1580	Target Neighborhood Hits	246	Shared Neighborhood Hits	165
SwissProt Accessions	O15389	Gene names	SIGLEC5, CD33L2, OBBP2
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 5 precursor (Siglec-5) (Obesity- binding protein 2) (OB-binding protein 2) (OB-BP2) (CD33 antigen-like 2) (CD170 antigen).

ANR18_HUMAN
NC score	0.074965 (rank : 1663)	θ value	θ > 10 (rank : 1609)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1106	Shared Neighborhood Hits	295
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

DCX_HUMAN
NC score	0.074898 (rank : 1664)	θ value	θ > 10 (rank : 1744)
Query Neighborhood Hits	1580	Target Neighborhood Hits	141	Shared Neighborhood Hits	33
SwissProt Accessions	O43602, O43911	Gene names	DCX, DBCN, LISX
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

BSN_HUMAN
NC score	0.074784 (rank : 1665)	θ value	1.06291 (rank : 1272)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1537	Shared Neighborhood Hits	351
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

LRRC4_MOUSE
NC score	0.074611 (rank : 1666)	θ value	0.00665767 (rank : 1018)
Query Neighborhood Hits	1580	Target Neighborhood Hits	412	Shared Neighborhood Hits	159
SwissProt Accessions	Q99PH1, Q8VI35	Gene names	Lrrc4
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing 4 protein precursor (Brain tumor- associated protein MBAG1).

ZWINT_HUMAN
NC score	0.074482 (rank : 1667)	θ value	θ > 10 (rank : 2218)
Query Neighborhood Hits	1580	Target Neighborhood Hits	333	Shared Neighborhood Hits	174
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

RADI_HUMAN
NC score	0.074473 (rank : 1668)	θ value	θ > 10 (rank : 2043)
Query Neighborhood Hits	1580	Target Neighborhood Hits	741	Shared Neighborhood Hits	264
SwissProt Accessions	P35241, Q86Y61	Gene names	RDX
Domain Architecture
Description	Radixin.

COVA1_MOUSE
NC score	0.074274 (rank : 1669)	θ value	3.0926 (rank : 1381)
Query Neighborhood Hits	1580	Target Neighborhood Hits	335	Shared Neighborhood Hits	157
SwissProt Accessions	Q8R0Z2, Q8BY59, Q8R372	Gene names	Cova1
Domain Architecture	No domain graphic available
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

RADI_MOUSE
NC score	0.074146 (rank : 1670)	θ value	θ > 10 (rank : 2044)
Query Neighborhood Hits	1580	Target Neighborhood Hits	773	Shared Neighborhood Hits	269
SwissProt Accessions	P26043, Q9QW27	Gene names	Rdx
Domain Architecture
Description	Radixin (ESP10).

VINEX_HUMAN
NC score	0.074119 (rank : 1671)	θ value	θ > 10 (rank : 2199)
Query Neighborhood Hits	1580	Target Neighborhood Hits	270	Shared Neighborhood Hits	100
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

EZRI_MOUSE
NC score	0.074117 (rank : 1672)	θ value	θ > 10 (rank : 1768)
Query Neighborhood Hits	1580	Target Neighborhood Hits	693	Shared Neighborhood Hits	272
SwissProt Accessions	P26040, Q80ZT8, Q9DCI1	Gene names	Vil2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

FINC_MOUSE
NC score	0.073829 (rank : 1673)	θ value	θ > 10 (rank : 1776)
Query Neighborhood Hits	1580	Target Neighborhood Hits	309	Shared Neighborhood Hits	132
SwissProt Accessions	P11276, Q61567, Q61568, Q61569, Q64233, Q80UI4	Gene names	Fn1
Domain Architecture
Description	Fibronectin precursor (FN).

DZIP1_HUMAN
NC score	0.073815 (rank : 1674)	θ value	θ > 10 (rank : 1760)
Query Neighborhood Hits	1580	Target Neighborhood Hits	675	Shared Neighborhood Hits	179
SwissProt Accessions	Q86YF9, Q8WY45, Q8WY46, Q9UGA5, Q9Y2K0	Gene names	DZIP1, DZIP, DZIP2, KIAA0996
Domain Architecture	No domain graphic available
Description	Zinc finger protein DZIP1 (DAZ-interacting protein 1/2).

LAMA2_MOUSE
NC score	0.073742 (rank : 1675)	θ value	0.00134147 (rank : 965)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1198	Shared Neighborhood Hits	297
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

RASA1_HUMAN
NC score	0.073714 (rank : 1676)	θ value	θ > 10 (rank : 2047)
Query Neighborhood Hits	1580	Target Neighborhood Hits	258	Shared Neighborhood Hits	89
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

STAM1_MOUSE
NC score	0.073645 (rank : 1677)	θ value	θ > 10 (rank : 2125)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	103
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

MFAP1_HUMAN
NC score	0.073587 (rank : 1678)	θ value	θ > 10 (rank : 1913)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	148
SwissProt Accessions	P55081	Gene names	MFAP1
Domain Architecture
Description	Microfibrillar-associated protein 1.

NCF2_HUMAN
NC score	0.073533 (rank : 1679)	θ value	θ > 10 (rank : 1956)
Query Neighborhood Hits	1580	Target Neighborhood Hits	229	Shared Neighborhood Hits	86
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

STAM1_HUMAN
NC score	0.073471 (rank : 1680)	θ value	8.99809 (rank : 1567)
Query Neighborhood Hits	1580	Target Neighborhood Hits	271	Shared Neighborhood Hits	104
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ZRF1_MOUSE
NC score	0.073263 (rank : 1681)	θ value	θ > 10 (rank : 2217)
Query Neighborhood Hits	1580	Target Neighborhood Hits	414	Shared Neighborhood Hits	171
SwissProt Accessions	P54103	Gene names	Zrf1, Dnajc2
Domain Architecture
Description	Zuotin-related factor 1.

PSG8_HUMAN
NC score	0.073249 (rank : 1682)	θ value	3.0926 (rank : 1402)
Query Neighborhood Hits	1580	Target Neighborhood Hits	239	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UQ74, O60410	Gene names	PSG8
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 8 precursor (PSBG-8).

CJ068_HUMAN
NC score	0.073228 (rank : 1683)	θ value	θ > 10 (rank : 1703)
Query Neighborhood Hits	1580	Target Neighborhood Hits	316	Shared Neighborhood Hits	131
SwissProt Accessions	Q9H943, Q8N7T7	Gene names	C10orf68
Domain Architecture	No domain graphic available
Description	Protein C10orf68.

CEAM8_HUMAN
NC score	0.073030 (rank : 1684)	θ value	θ > 10 (rank : 1675)
Query Neighborhood Hits	1580	Target Neighborhood Hits	264	Shared Neighborhood Hits	185
SwissProt Accessions	P31997, O60399, Q16574	Gene names	CEACAM8, CGM6
Domain Architecture
Description	Carcinoembryonic antigen-related cell adhesion molecule 8 precursor (Carcinoembryonic antigen CGM6) (Nonspecific cross-reacting antigen NCA-95) (CD67 antigen) (CD66b antigen).

IL1R2_HUMAN
NC score	0.073024 (rank : 1685)	θ value	θ > 10 (rank : 1829)
Query Neighborhood Hits	1580	Target Neighborhood Hits	153	Shared Neighborhood Hits	112
SwissProt Accessions	P27930, Q9UE68	Gene names	IL1R2, IL1RB
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen) (CDw121b).

OLR1_MOUSE
NC score	0.072670 (rank : 1686)	θ value	θ > 10 (rank : 1979)
Query Neighborhood Hits	1580	Target Neighborhood Hits	596	Shared Neighborhood Hits	225
SwissProt Accessions	Q9EQ09	Gene names	Olr1, Lox1
Domain Architecture	No domain graphic available
Description	Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (Lectin-type oxidized LDL receptor 1) (Lectin-like oxidized LDL receptor 1) (Lectin-like oxLDL receptor 1) (LOX-1) [Contains: Oxidized low-density lipoprotein receptor 1, soluble form].

PRC1_MOUSE
NC score	0.072603 (rank : 1687)	θ value	θ > 10 (rank : 2030)
Query Neighborhood Hits	1580	Target Neighborhood Hits	382	Shared Neighborhood Hits	190
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

MICA1_MOUSE
NC score	0.072597 (rank : 1688)	θ value	θ > 10 (rank : 1916)
Query Neighborhood Hits	1580	Target Neighborhood Hits	400	Shared Neighborhood Hits	187
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

PSG3_HUMAN
NC score	0.072517 (rank : 1689)	θ value	5.27518 (rank : 1466)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	168
SwissProt Accessions	Q16557, Q08265, Q9BRW2, Q9UPL4, Q9UQ77	Gene names	PSG3
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 3 precursor (PSBG-3) (Carcinoembryonic antigen SG5).

BCN1_HUMAN
NC score	0.072406 (rank : 1690)	θ value	θ > 10 (rank : 1621)
Query Neighborhood Hits	1580	Target Neighborhood Hits	395	Shared Neighborhood Hits	205
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

CCDC7_HUMAN
NC score	0.072360 (rank : 1691)	θ value	θ > 10 (rank : 1665)
Query Neighborhood Hits	1580	Target Neighborhood Hits	253	Shared Neighborhood Hits	129
SwissProt Accessions	Q96M83, Q8IVQ0, Q8NEQ0	Gene names	CCDC7
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 7.

CDC37_HUMAN
NC score	0.072274 (rank : 1692)	θ value	θ > 10 (rank : 1671)
Query Neighborhood Hits	1580	Target Neighborhood Hits	506	Shared Neighborhood Hits	206
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

STAM2_MOUSE
NC score	0.072215 (rank : 1693)	θ value	θ > 10 (rank : 2127)
Query Neighborhood Hits	1580	Target Neighborhood Hits	285	Shared Neighborhood Hits	108
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

EMB_MOUSE
NC score	0.072163 (rank : 1694)	θ value	0.62314 (rank : 1236)
Query Neighborhood Hits	1580	Target Neighborhood Hits	83	Shared Neighborhood Hits	72
SwissProt Accessions	P21995, Q3UFF1, Q8C2J8, Q8C543, Q96C38	Gene names	Emb, Gp70
Domain Architecture
Description	Embigin precursor (Teratocarcinoma glycoprotein Gp-70).

SKIL_HUMAN
NC score	0.071993 (rank : 1695)	θ value	θ > 10 (rank : 2099)
Query Neighborhood Hits	1580	Target Neighborhood Hits	460	Shared Neighborhood Hits	209
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SRBS1_MOUSE
NC score	0.071950 (rank : 1696)	θ value	θ > 10 (rank : 2114)
Query Neighborhood Hits	1580	Target Neighborhood Hits	409	Shared Neighborhood Hits	130
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PSG4_HUMAN
NC score	0.071935 (rank : 1697)	θ value	1.38821 (rank : 1315)
Query Neighborhood Hits	1580	Target Neighborhood Hits	243	Shared Neighborhood Hits	170
SwissProt Accessions	Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76	Gene names	PSG4, CGM4, PSG9
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 4 precursor (PSBG-4) (PSBG-9).

FINC_HUMAN
NC score	0.071915 (rank : 1698)	θ value	θ > 10 (rank : 1775)
Query Neighborhood Hits	1580	Target Neighborhood Hits	302	Shared Neighborhood Hits	131
SwissProt Accessions	P02751, O95609, O95610, Q14312, Q14325, Q14326, Q6LDP6, Q86T27, Q8IVI8, Q96KP7, Q96KP8, Q96KP9, Q9H1B8, Q9HAP3, Q9UMK2	Gene names	FN1, FN
Domain Architecture
Description	Fibronectin precursor (FN) (Cold-insoluble globulin) (CIG).

STXB4_MOUSE
NC score	0.071581 (rank : 1699)	θ value	θ > 10 (rank : 2135)
Query Neighborhood Hits	1580	Target Neighborhood Hits	629	Shared Neighborhood Hits	233
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

LMNB2_HUMAN
NC score	0.071525 (rank : 1700)	θ value	θ > 10 (rank : 1888)
Query Neighborhood Hits	1580	Target Neighborhood Hits	723	Shared Neighborhood Hits	265
SwissProt Accessions	Q03252, O75292, Q14734, Q96DF6	Gene names	LMNB2, LMN2
Domain Architecture
Description	Lamin-B2.

DCX_MOUSE
NC score	0.071235 (rank : 1701)	θ value	θ > 10 (rank : 1745)
Query Neighborhood Hits	1580	Target Neighborhood Hits	124	Shared Neighborhood Hits	23
SwissProt Accessions	O88809	Gene names	Dcx, Dcn
Domain Architecture
Description	Neuronal migration protein doublecortin (Lissencephalin-X) (Lis-X) (Doublin).

FA50A_MOUSE
NC score	0.071170 (rank : 1702)	θ value	θ > 10 (rank : 1770)
Query Neighborhood Hits	1580	Target Neighborhood Hits	293	Shared Neighborhood Hits	165
SwissProt Accessions	Q9WV03, Q9D866	Gene names	Fam50a, D0HXS9928E, Xap5
Domain Architecture
Description	Protein FAM50A (XAP-5 protein).

DGKQ_HUMAN
NC score	0.070960 (rank : 1703)	θ value	θ > 10 (rank : 1751)
Query Neighborhood Hits	1580	Target Neighborhood Hits	131	Shared Neighborhood Hits	43
SwissProt Accessions	P52824	Gene names	DGKQ, DAGK4
Domain Architecture
Description	Diacylglycerol kinase theta (EC 2.7.1.107) (Diglyceride kinase theta) (DGK-theta) (DAG kinase theta).

OSTF1_HUMAN
NC score	0.070878 (rank : 1704)	θ value	θ > 10 (rank : 1981)
Query Neighborhood Hits	1580	Target Neighborhood Hits	466	Shared Neighborhood Hits	106
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SH21A_MOUSE
NC score	0.070752 (rank : 1705)	θ value	θ > 10 (rank : 2078)
Query Neighborhood Hits	1580	Target Neighborhood Hits	89	Shared Neighborhood Hits	42
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

MYO9B_HUMAN
NC score	0.070693 (rank : 1706)	θ value	θ > 10 (rank : 1950)
Query Neighborhood Hits	1580	Target Neighborhood Hits	641	Shared Neighborhood Hits	159
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

PGFRL_MOUSE
NC score	0.070675 (rank : 1707)	θ value	θ > 10 (rank : 2003)
Query Neighborhood Hits	1580	Target Neighborhood Hits	106	Shared Neighborhood Hits	93
SwissProt Accessions	Q6PE55, Q3V182, Q9D0Z1	Gene names	Pdgfrl
Domain Architecture	No domain graphic available
Description	Platelet-derived growth factor receptor-like protein precursor.

NTBP1_MOUSE
NC score	0.070674 (rank : 1708)	θ value	θ > 10 (rank : 1972)
Query Neighborhood Hits	1580	Target Neighborhood Hits	528	Shared Neighborhood Hits	200
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

EZRI_HUMAN
NC score	0.070551 (rank : 1709)	θ value	θ > 10 (rank : 1767)
Query Neighborhood Hits	1580	Target Neighborhood Hits	663	Shared Neighborhood Hits	258
SwissProt Accessions	P15311, P23714, Q96CU8, Q9NSJ4	Gene names	VIL2
Domain Architecture
Description	Ezrin (p81) (Cytovillin) (Villin-2).

NFM_HUMAN
NC score	0.070518 (rank : 1710)	θ value	θ > 10 (rank : 1969)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1328	Shared Neighborhood Hits	353
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

ES8L3_HUMAN
NC score	0.070449 (rank : 1711)	θ value	2.36792 (rank : 1352)
Query Neighborhood Hits	1580	Target Neighborhood Hits	206	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

LRRF1_HUMAN
NC score	0.070376 (rank : 1712)	θ value	θ > 10 (rank : 1895)
Query Neighborhood Hits	1580	Target Neighborhood Hits	625	Shared Neighborhood Hits	210
SwissProt Accessions	Q32MZ4, O75766, O75799, Q32MZ5, Q53T49, Q6PKG2	Gene names	LRRFIP1, GCF2, TRIP
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 1 (LRR FLII- interacting protein 1) (TAR RNA-interacting protein) (GC-binding factor 2).

CN045_HUMAN
NC score	0.070260 (rank : 1713)	θ value	θ > 10 (rank : 1711)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	138
SwissProt Accessions	Q8ND07, Q9H5P8	Gene names	C14orf45
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf45.

GLE1_HUMAN
NC score	0.070250 (rank : 1714)	θ value	θ > 10 (rank : 1792)
Query Neighborhood Hits	1580	Target Neighborhood Hits	445	Shared Neighborhood Hits	185
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

STAM2_HUMAN
NC score	0.070179 (rank : 1715)	θ value	θ > 10 (rank : 2126)
Query Neighborhood Hits	1580	Target Neighborhood Hits	288	Shared Neighborhood Hits	116
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SH21B_HUMAN
NC score	0.070039 (rank : 1716)	θ value	θ > 10 (rank : 2079)
Query Neighborhood Hits	1580	Target Neighborhood Hits	101	Shared Neighborhood Hits	44
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SIGL6_HUMAN
NC score	0.069964 (rank : 1717)	θ value	θ > 10 (rank : 2097)
Query Neighborhood Hits	1580	Target Neighborhood Hits	233	Shared Neighborhood Hits	166
SwissProt Accessions	O43699, O15388, O43700	Gene names	SIGLEC6, CD33L, CD33L1, OBBP1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 6 precursor (Siglec-6) (Obesity- binding protein 1) (OB-BP1) (CD33 antigen-like 1) (CDw327 antigen).

NEB1_HUMAN
NC score	0.069825 (rank : 1718)	θ value	θ > 10 (rank : 1963)
Query Neighborhood Hits	1580	Target Neighborhood Hits	829	Shared Neighborhood Hits	269
SwissProt Accessions	Q9ULJ8, O76059, Q9NXT2	Gene names	PPP1R9A, KIAA1222
Domain Architecture	No domain graphic available
Description	Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A).

BRAP_HUMAN
NC score	0.069674 (rank : 1719)	θ value	θ > 10 (rank : 1634)
Query Neighborhood Hits	1580	Target Neighborhood Hits	560	Shared Neighborhood Hits	210
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

DYHC_HUMAN
NC score	0.069515 (rank : 1720)	θ value	θ > 10 (rank : 1758)
Query Neighborhood Hits	1580	Target Neighborhood Hits	733	Shared Neighborhood Hits	258
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

DYHC_MOUSE
NC score	0.069365 (rank : 1721)	θ value	θ > 10 (rank : 1759)
Query Neighborhood Hits	1580	Target Neighborhood Hits	729	Shared Neighborhood Hits	259
SwissProt Accessions	Q9JHU4	Gene names	Dync1h1, Dnch1, Dnchc1
Domain Architecture
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

PSG11_HUMAN
NC score	0.069324 (rank : 1722)	θ value	3.0926 (rank : 1400)
Query Neighborhood Hits	1580	Target Neighborhood Hits	223	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UQ72, Q13179, Q15242, Q9UNE4	Gene names	PSG11, PSG13
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 11 precursor (PSBG-11) (PSBG- 13).

LMNA_HUMAN
NC score	0.069305 (rank : 1723)	θ value	θ > 10 (rank : 1886)
Query Neighborhood Hits	1580	Target Neighborhood Hits	653	Shared Neighborhood Hits	269
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

PSG7_HUMAN
NC score	0.069300 (rank : 1724)	θ value	6.88961 (rank : 1507)
Query Neighborhood Hits	1580	Target Neighborhood Hits	239	Shared Neighborhood Hits	167
SwissProt Accessions	Q13046, Q15232	Gene names	PSG7
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 7 precursor (PSBG-7).

CENPK_HUMAN
NC score	0.069178 (rank : 1725)	θ value	θ > 10 (rank : 1679)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BS16, Q9H4L0	Gene names	CENPK, ICEN37
Domain Architecture	No domain graphic available
Description	Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33).

CXAR_HUMAN
NC score	0.069142 (rank : 1726)	θ value	θ > 10 (rank : 1739)
Query Neighborhood Hits	1580	Target Neighborhood Hits	245	Shared Neighborhood Hits	139
SwissProt Accessions	P78310, O00694, Q8WWT6, Q8WWT7, Q8WWT8, Q9UKV4	Gene names	CXADR, CAR
Domain Architecture
Description	Coxsackievirus and adenovirus receptor precursor (Coxsackievirus B- adenovirus receptor) (hCAR) (CVB3-binding protein) (HCVADR).

P85A_MOUSE
NC score	0.069099 (rank : 1727)	θ value	θ > 10 (rank : 1986)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	170
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PHLB1_MOUSE
NC score	0.069070 (rank : 1728)	θ value	θ > 10 (rank : 2005)
Query Neighborhood Hits	1580	Target Neighborhood Hits	678	Shared Neighborhood Hits	242
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

LMNA_MOUSE
NC score	0.069061 (rank : 1729)	θ value	θ > 10 (rank : 1887)
Query Neighborhood Hits	1580	Target Neighborhood Hits	661	Shared Neighborhood Hits	274
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

TNNT2_MOUSE
NC score	0.068928 (rank : 1730)	θ value	θ > 10 (rank : 2161)
Query Neighborhood Hits	1580	Target Neighborhood Hits	395	Shared Neighborhood Hits	181
SwissProt Accessions	P50752, Q64360, Q64377	Gene names	Tnnt2
Domain Architecture	No domain graphic available
Description	Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT).

PSG2_HUMAN
NC score	0.068833 (rank : 1731)	θ value	1.81305 (rank : 1338)
Query Neighborhood Hits	1580	Target Neighborhood Hits	229	Shared Neighborhood Hits	166
SwissProt Accessions	P11465, Q8TCD9, Q9UEA4, Q9UQ78	Gene names	PSG2
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 2 precursor (PSBG-2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E).

LAMA4_HUMAN
NC score	0.068720 (rank : 1732)	θ value	0.62314 (rank : 1240)
Query Neighborhood Hits	1580	Target Neighborhood Hits	708	Shared Neighborhood Hits	224
SwissProt Accessions	Q16363, Q14735, Q15335, Q4LE44, Q5SZG8, Q9UE18, Q9UJN9	Gene names	LAMA4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

MYO9B_MOUSE
NC score	0.068553 (rank : 1733)	θ value	θ > 10 (rank : 1951)
Query Neighborhood Hits	1580	Target Neighborhood Hits	311	Shared Neighborhood Hits	108
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NFM_MOUSE
NC score	0.068472 (rank : 1734)	θ value	θ > 10 (rank : 1970)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1159	Shared Neighborhood Hits	327
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

NUCB2_MOUSE
NC score	0.068210 (rank : 1735)	θ value	1.06291 (rank : 1289)
Query Neighborhood Hits	1580	Target Neighborhood Hits	459	Shared Neighborhood Hits	203
SwissProt Accessions	P81117	Gene names	Nucb2, Nefa
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA).

CUTL2_HUMAN
NC score	0.068151 (rank : 1736)	θ value	θ > 10 (rank : 1737)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	263
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CLUA1_MOUSE
NC score	0.068112 (rank : 1737)	θ value	θ > 10 (rank : 1710)
Query Neighborhood Hits	1580	Target Neighborhood Hits	261	Shared Neighborhood Hits	143
SwissProt Accessions	Q8R3P7, Q6P3Y8	Gene names	Cluap1
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

CLC4F_MOUSE
NC score	0.068104 (rank : 1738)	θ value	θ > 10 (rank : 1707)
Query Neighborhood Hits	1580	Target Neighborhood Hits	572	Shared Neighborhood Hits	212
SwissProt Accessions	P70194, Q8BLZ8	Gene names	Clec4f, Clecsf13, Kclr
Domain Architecture
Description	C-type lectin domain family 4 member F (C-type lectin superfamily member 13) (C-type lectin 13) (Kupffer cell receptor).

PACN2_HUMAN
NC score	0.067953 (rank : 1739)	θ value	θ > 10 (rank : 1993)
Query Neighborhood Hits	1580	Target Neighborhood Hits	339	Shared Neighborhood Hits	163
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
NC score	0.067922 (rank : 1740)	θ value	θ > 10 (rank : 1994)
Query Neighborhood Hits	1580	Target Neighborhood Hits	382	Shared Neighborhood Hits	174
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

DAPP1_HUMAN
NC score	0.067799 (rank : 1741)	θ value	θ > 10 (rank : 1742)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

WDR67_MOUSE
NC score	0.067661 (rank : 1742)	θ value	θ > 10 (rank : 2209)
Query Neighborhood Hits	1580	Target Neighborhood Hits	476	Shared Neighborhood Hits	176
SwissProt Accessions	Q6NXY1, Q3TBW4, Q3U4F6, Q5KSA3, Q810J7, Q8C3Y2	Gene names	Wdr67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67 (Protein 4-B-3).

CCD22_MOUSE
NC score	0.067591 (rank : 1743)	θ value	θ > 10 (rank : 1652)
Query Neighborhood Hits	1580	Target Neighborhood Hits	268	Shared Neighborhood Hits	149
SwissProt Accessions	Q9JIG7, Q8BYH4	Gene names	Ccdc22, DXImx40e
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CAR14_HUMAN
NC score	0.067562 (rank : 1744)	θ value	θ > 10 (rank : 1643)
Query Neighborhood Hits	1580	Target Neighborhood Hits	449	Shared Neighborhood Hits	197
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

RENT2_HUMAN
NC score	0.067561 (rank : 1745)	θ value	θ > 10 (rank : 2058)
Query Neighborhood Hits	1580	Target Neighborhood Hits	618	Shared Neighborhood Hits	215
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

PCQAP_HUMAN
NC score	0.067555 (rank : 1746)	θ value	0.163984 (rank : 1164)
Query Neighborhood Hits	1580	Target Neighborhood Hits	549	Shared Neighborhood Hits	182
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PSG1_HUMAN
NC score	0.067327 (rank : 1747)	θ value	θ > 10 (rank : 2034)
Query Neighborhood Hits	1580	Target Neighborhood Hits	232	Shared Neighborhood Hits	167
SwissProt Accessions	P11464, O75236, P11462, P11463, Q15231, Q15241, Q15243, Q16660, Q9P1W5, Q9UQ79	Gene names	PSG1, B1G1, PSGGA
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 1 precursor (PSBG-1) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (CD66f antigen).

YO11_MOUSE
NC score	0.067098 (rank : 1748)	θ value	θ > 10 (rank : 2213)
Query Neighborhood Hits	1580	Target Neighborhood Hits	272	Shared Neighborhood Hits	133
SwissProt Accessions	P11260	Gene names
Domain Architecture
Description	Hypothetical protein ORF-1137.

OSTF1_MOUSE
NC score	0.066954 (rank : 1749)	θ value	θ > 10 (rank : 1982)
Query Neighborhood Hits	1580	Target Neighborhood Hits	467	Shared Neighborhood Hits	106
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

CENPH_MOUSE
NC score	0.066837 (rank : 1750)	θ value	θ > 10 (rank : 1677)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	123
SwissProt Accessions	Q9QYM8, Q8R3K9, Q9D079, Q9D0N1	Gene names	Cenph, Enp
Domain Architecture	No domain graphic available
Description	Centromere protein H (CENP-H).

SKI_MOUSE
NC score	0.066836 (rank : 1751)	θ value	θ > 10 (rank : 2102)
Query Neighborhood Hits	1580	Target Neighborhood Hits	423	Shared Neighborhood Hits	191
SwissProt Accessions	Q60698, Q8VIL5	Gene names	Ski
Domain Architecture	No domain graphic available
Description	Ski oncogene (C-ski).

IL6RB_HUMAN
NC score	0.066777 (rank : 1752)	θ value	θ > 10 (rank : 1831)
Query Neighborhood Hits	1580	Target Neighborhood Hits	181	Shared Neighborhood Hits	88
SwissProt Accessions	P40189, Q9UQ41	Gene names	IL6ST
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin M receptor) (CD130 antigen) (CDw130).

BCN1_MOUSE
NC score	0.066774 (rank : 1753)	θ value	θ > 10 (rank : 1622)
Query Neighborhood Hits	1580	Target Neighborhood Hits	367	Shared Neighborhood Hits	190
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

DRP2_HUMAN
NC score	0.066733 (rank : 1754)	θ value	θ > 10 (rank : 1757)
Query Neighborhood Hits	1580	Target Neighborhood Hits	186	Shared Neighborhood Hits	98
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

K0494_HUMAN
NC score	0.066718 (rank : 1755)	θ value	θ > 10 (rank : 1849)
Query Neighborhood Hits	1580	Target Neighborhood Hits	230	Shared Neighborhood Hits	126
SwissProt Accessions	O75071	Gene names	KIAA0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

CXAR_MOUSE
NC score	0.066625 (rank : 1756)	θ value	θ > 10 (rank : 1740)
Query Neighborhood Hits	1580	Target Neighborhood Hits	250	Shared Neighborhood Hits	141
SwissProt Accessions	P97792, O09052, Q3ULD0, Q91W66, Q99KG0, Q9DBJ8	Gene names	Cxadr, Car
Domain Architecture
Description	Coxsackievirus and adenovirus receptor homolog precursor (CAR) (mCAR).

PACN3_HUMAN
NC score	0.066496 (rank : 1757)	θ value	θ > 10 (rank : 1995)
Query Neighborhood Hits	1580	Target Neighborhood Hits	385	Shared Neighborhood Hits	186
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

DAPP1_MOUSE
NC score	0.066414 (rank : 1758)	θ value	θ > 10 (rank : 1743)
Query Neighborhood Hits	1580	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

LMNB2_MOUSE
NC score	0.066048 (rank : 1759)	θ value	θ > 10 (rank : 1889)
Query Neighborhood Hits	1580	Target Neighborhood Hits	674	Shared Neighborhood Hits	255
SwissProt Accessions	P21619, P48680, Q8CGB1	Gene names	Lmnb2
Domain Architecture
Description	Lamin-B2.

LETM1_MOUSE
NC score	0.065995 (rank : 1760)	θ value	5.27518 (rank : 1460)
Query Neighborhood Hits	1580	Target Neighborhood Hits	240	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Z2I0, Q5PQC5, Q7TMK8, Q80ZX6, Q8CGJ3, Q8K5E5	Gene names	Letm1
Domain Architecture	No domain graphic available
Description	Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial precursor.

KI21A_HUMAN
NC score	0.065967 (rank : 1761)	θ value	0.47712 (rank : 1227)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1543	Shared Neighborhood Hits	341
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

CD276_HUMAN
NC score	0.065916 (rank : 1762)	θ value	4.03905 (rank : 1423)
Query Neighborhood Hits	1580	Target Neighborhood Hits	261	Shared Neighborhood Hits	129
SwissProt Accessions	Q5ZPR3, Q6P5Y4, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1	Gene names	CD276, B7H3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3) (4Ig-B7-H3).

RASF1_HUMAN
NC score	0.065897 (rank : 1763)	θ value	θ > 10 (rank : 2048)
Query Neighborhood Hits	1580	Target Neighborhood Hits	62	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NS23, O14571, O60539, O60710, Q9HB04, Q9HB18, Q9NS22, Q9UND4, Q9UND5	Gene names	RASSF1, RDA32
Domain Architecture	No domain graphic available
Description	Ras association domain-containing protein 1.

LAMA3_HUMAN
NC score	0.065766 (rank : 1764)	θ value	θ > 10 (rank : 1875)
Query Neighborhood Hits	1580	Target Neighborhood Hits	760	Shared Neighborhood Hits	238
SwissProt Accessions	Q16787, Q13679, Q13680, Q96TG0	Gene names	LAMA3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Epiligrin 170 kDa subunit) (E170) (Nicein subunit alpha).

SH21A_HUMAN
NC score	0.065491 (rank : 1765)	θ value	θ > 10 (rank : 2077)
Query Neighborhood Hits	1580	Target Neighborhood Hits	89	Shared Neighborhood Hits	41
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

DREB_HUMAN
NC score	0.065392 (rank : 1766)	θ value	θ > 10 (rank : 1755)
Query Neighborhood Hits	1580	Target Neighborhood Hits	450	Shared Neighborhood Hits	192
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

PECA1_HUMAN
NC score	0.065372 (rank : 1767)	θ value	6.88961 (rank : 1505)
Query Neighborhood Hits	1580	Target Neighborhood Hits	178	Shared Neighborhood Hits	123
SwissProt Accessions	P16284, Q6LDA9, Q8TBH1, Q96RF5, Q96RF6, Q9NP65, Q9NPB7, Q9NPG9, Q9NQS9, Q9NQT0, Q9NQT1, Q9NQT2	Gene names	PECAM1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (EndoCAM) (GPIIA') (CD31 antigen).

BSN_MOUSE
NC score	0.065259 (rank : 1768)	θ value	0.125558 (rank : 1141)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2057	Shared Neighborhood Hits	375
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CEP72_MOUSE
NC score	0.065042 (rank : 1769)	θ value	θ > 10 (rank : 1689)
Query Neighborhood Hits	1580	Target Neighborhood Hits	381	Shared Neighborhood Hits	172
SwissProt Accessions	Q9D3R3, Q8BM53, Q9D0B7	Gene names	Cep72
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

PKHF1_MOUSE
NC score	0.065003 (rank : 1770)	θ value	1.38821 (rank : 1313)
Query Neighborhood Hits	1580	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF1_HUMAN
NC score	0.064957 (rank : 1771)	θ value	3.0926 (rank : 1399)
Query Neighborhood Hits	1580	Target Neighborhood Hits	76	Shared Neighborhood Hits	28
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

U2AFM_HUMAN
NC score	0.064894 (rank : 1772)	θ value	θ > 10 (rank : 2185)
Query Neighborhood Hits	1580	Target Neighborhood Hits	577	Shared Neighborhood Hits	217
SwissProt Accessions	Q15696	Gene names	ZRSR2, U2AF1-RS2, U2AF1L2, U2AF1RS2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (NY-REN-20 antigen).

PACN1_HUMAN
NC score	0.064871 (rank : 1773)	θ value	θ > 10 (rank : 1991)
Query Neighborhood Hits	1580	Target Neighborhood Hits	320	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

BFSP1_HUMAN
NC score	0.064722 (rank : 1774)	θ value	θ > 10 (rank : 1625)
Query Neighborhood Hits	1580	Target Neighborhood Hits	508	Shared Neighborhood Hits	227
SwissProt Accessions	Q12934, O43595, O76034, Q9HBX4	Gene names	BFSP1
Domain Architecture
Description	Filensin (Beaded filament structural protein 1) (Lens fiber cell beaded-filament structural protein CP 115) (CP115) (Lens intermediate filament-like heavy) (LIFL-H).

PSG6_HUMAN
NC score	0.064690 (rank : 1775)	θ value	θ > 10 (rank : 2035)
Query Neighborhood Hits	1580	Target Neighborhood Hits	231	Shared Neighborhood Hits	163
SwissProt Accessions	Q00889	Gene names	PSG6, CGM3, PSGGB
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 6 precursor (PSBG-6).

SH3G2_HUMAN
NC score	0.064576 (rank : 1776)	θ value	θ > 10 (rank : 2084)
Query Neighborhood Hits	1580	Target Neighborhood Hits	324	Shared Neighborhood Hits	141
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

IRPL2_HUMAN
NC score	0.064390 (rank : 1777)	θ value	θ > 10 (rank : 1840)
Query Neighborhood Hits	1580	Target Neighborhood Hits	194	Shared Neighborhood Hits	131
SwissProt Accessions	Q9NP60, Q9NZN0	Gene names	IL1RAPL2, IL1R9
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (Interleukin-1 receptor 9) (IL-1R9) (IL-1 receptor accessory protein-like 2) (Three immunoglobulin domain- containing IL-1 receptor-related 1) (TIGIRR-1).

PKHF2_HUMAN
NC score	0.064359 (rank : 1778)	θ value	θ > 10 (rank : 2016)
Query Neighborhood Hits	1580	Target Neighborhood Hits	75	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

SEC20_HUMAN
NC score	0.064246 (rank : 1779)	θ value	0.62314 (rank : 1244)
Query Neighborhood Hits	1580	Target Neighborhood Hits	200	Shared Neighborhood Hits	127
SwissProt Accessions	Q12981, O75622, O75623, O75624, Q6K044, Q96FG4	Gene names	BNIP1, NIP1, SEC20L, TRG8
Domain Architecture
Description	Vesicle transport protein SEC20 (BCL2/adenovirus E1B 19 kDa protein- interacting protein 1) (Transformation-related gene 8 protein) (TRG- 8).

DREB_MOUSE
NC score	0.064227 (rank : 1780)	θ value	θ > 10 (rank : 1756)
Query Neighborhood Hits	1580	Target Neighborhood Hits	446	Shared Neighborhood Hits	194
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

NUP88_HUMAN
NC score	0.064201 (rank : 1781)	θ value	θ > 10 (rank : 1978)
Query Neighborhood Hits	1580	Target Neighborhood Hits	354	Shared Neighborhood Hits	183
SwissProt Accessions	Q99567, Q9BWE5	Gene names	NUP88
Domain Architecture	No domain graphic available
Description	Nuclear pore complex protein Nup88 (Nucleoporin Nup88) (88 kDa nuclear pore complex protein).

HAP1_MOUSE
NC score	0.064139 (rank : 1782)	θ value	θ > 10 (rank : 1808)
Query Neighborhood Hits	1580	Target Neighborhood Hits	388	Shared Neighborhood Hits	188
SwissProt Accessions	O35668, O35636	Gene names	Hap1
Domain Architecture
Description	Huntingtin-associated protein 1 (HAP-1).

PKHF2_MOUSE
NC score	0.064097 (rank : 1783)	θ value	θ > 10 (rank : 2017)
Query Neighborhood Hits	1580	Target Neighborhood Hits	77	Shared Neighborhood Hits	27
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

PACE1_MOUSE
NC score	0.063937 (rank : 1784)	θ value	θ > 10 (rank : 1990)
Query Neighborhood Hits	1580	Target Neighborhood Hits	92	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DBQ7, Q6NY01, Q8BQC9, Q8BRJ1	Gene names	Scyl3, Pace1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

PSG5_HUMAN
NC score	0.063788 (rank : 1785)	θ value	3.0926 (rank : 1401)
Query Neighborhood Hits	1580	Target Neighborhood Hits	231	Shared Neighborhood Hits	161
SwissProt Accessions	Q15238, Q15239, Q96QJ1, Q9UQ75	Gene names	PSG5
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 5 precursor (PSBG-5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3).

CILP1_MOUSE
NC score	0.063542 (rank : 1786)	θ value	θ > 10 (rank : 1700)
Query Neighborhood Hits	1580	Target Neighborhood Hits	282	Shared Neighborhood Hits	157
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

NUCB2_HUMAN
NC score	0.063473 (rank : 1787)	θ value	0.279714 (rank : 1196)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	162
SwissProt Accessions	P80303, Q8NFT5	Gene names	NUCB2, NEFA
Domain Architecture	No domain graphic available
Description	Nucleobindin-2 precursor (DNA-binding protein NEFA) (Gastric cancer antigen Zg4).

IRPL2_MOUSE
NC score	0.063411 (rank : 1788)	θ value	θ > 10 (rank : 1841)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	128
SwissProt Accessions	Q9ERS6, Q9ER66	Gene names	Il1rapl2
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 2 precursor (IL1RAPL-2-related protein) (TIGIRR-1).

PSG10_HUMAN
NC score	0.063328 (rank : 1789)	θ value	θ > 10 (rank : 2033)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	162
SwissProt Accessions	Q15235, O75244, Q15224	Gene names	PSG10, PSG12
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 10 precursor (PSBG-10) (PSBG- 12).

TNNT3_MOUSE
NC score	0.063196 (rank : 1790)	θ value	θ > 10 (rank : 2163)
Query Neighborhood Hits	1580	Target Neighborhood Hits	317	Shared Neighborhood Hits	153
SwissProt Accessions	Q9QZ47, O35575, O35576, O35577, O35578, O35579, O35580, O35581, O35582, O35583, O35584, O35585, P97456, Q99L89, Q9QZ46	Gene names	Tnnt3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT).

FA50A_HUMAN
NC score	0.063194 (rank : 1791)	θ value	θ > 10 (rank : 1769)
Query Neighborhood Hits	1580	Target Neighborhood Hits	264	Shared Neighborhood Hits	152
SwissProt Accessions	Q14320, Q5HY37	Gene names	FAM50A, DXS9928E, HXC26, XAP5
Domain Architecture
Description	Protein FAM50A (Protein XAP-5) (Protein HXC-26).

PACE1_HUMAN
NC score	0.063098 (rank : 1792)	θ value	θ > 10 (rank : 1989)
Query Neighborhood Hits	1580	Target Neighborhood Hits	74	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IZE3, Q5THA6, Q5THA8, Q8IZN9, Q96C56, Q9UBK6	Gene names	SCYL3, PACE1
Domain Architecture	No domain graphic available
Description	Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin- binding protein PACE-1) (SCY1-like protein 3).

HCLS1_MOUSE
NC score	0.062971 (rank : 1793)	θ value	θ > 10 (rank : 1811)
Query Neighborhood Hits	1580	Target Neighborhood Hits	329	Shared Neighborhood Hits	109
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SKI_HUMAN
NC score	0.062939 (rank : 1794)	θ value	θ > 10 (rank : 2101)
Query Neighborhood Hits	1580	Target Neighborhood Hits	423	Shared Neighborhood Hits	198
SwissProt Accessions	P12755, Q5SYT7	Gene names	SKI
Domain Architecture
Description	Ski oncogene (C-ski).

CCD22_HUMAN
NC score	0.062873 (rank : 1795)	θ value	θ > 10 (rank : 1651)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	142
SwissProt Accessions	O60826	Gene names	CCDC22, CXorf37
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 22.

CENPU_HUMAN
NC score	0.062858 (rank : 1796)	θ value	θ > 10 (rank : 1680)
Query Neighborhood Hits	1580	Target Neighborhood Hits	289	Shared Neighborhood Hits	156
SwissProt Accessions	Q71F23, Q32Q71, Q9H5G1	Gene names	MLF1IP, CENPU, ICEN24, KLIP1
Domain Architecture	No domain graphic available
Description	Centromere protein U (CENP-U) (CENP-U(50)) (CENP-50) (Interphase centromere complex protein 24) (MLF1-interacting protein) (KSHV latent nuclear antigen-interacting protein 1).

LAMC1_HUMAN
NC score	0.062746 (rank : 1797)	θ value	0.125558 (rank : 1147)
Query Neighborhood Hits	1580	Target Neighborhood Hits	922	Shared Neighborhood Hits	272
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

ES8L2_HUMAN
NC score	0.062723 (rank : 1798)	θ value	0.0252991 (rank : 1067)
Query Neighborhood Hits	1580	Target Neighborhood Hits	193	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

U2AFL_HUMAN
NC score	0.062683 (rank : 1799)	θ value	θ > 10 (rank : 2184)
Query Neighborhood Hits	1580	Target Neighborhood Hits	503	Shared Neighborhood Hits	202
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

TRDN_HUMAN
NC score	0.062682 (rank : 1800)	θ value	θ > 10 (rank : 2173)
Query Neighborhood Hits	1580	Target Neighborhood Hits	542	Shared Neighborhood Hits	162
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

SHE_MOUSE
NC score	0.062660 (rank : 1801)	θ value	θ > 10 (rank : 2095)
Query Neighborhood Hits	1580	Target Neighborhood Hits	169	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

PSG9_HUMAN
NC score	0.062592 (rank : 1802)	θ value	θ > 10 (rank : 2036)
Query Neighborhood Hits	1580	Target Neighborhood Hits	221	Shared Neighborhood Hits	162
SwissProt Accessions	Q00887, Q15236, Q15237, Q8WW78, Q9UQ73	Gene names	PSG9, PSG11
Domain Architecture
Description	Pregnancy-specific beta-1-glycoprotein 9 precursor (PSBG-9) (Pregnancy-specific glycoprotein 9) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (PS34) (Pregnancy-specific glycoprotein 7) (PSG7).

IDLC_HUMAN
NC score	0.062570 (rank : 1803)	θ value	θ > 10 (rank : 1822)
Query Neighborhood Hits	1580	Target Neighborhood Hits	348	Shared Neighborhood Hits	169
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

CT116_HUMAN
NC score	0.062485 (rank : 1804)	θ value	θ > 10 (rank : 1727)
Query Neighborhood Hits	1580	Target Neighborhood Hits	294	Shared Neighborhood Hits	143
SwissProt Accessions	Q96HY6, Q9BW47	Gene names	C20orf116
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf116 precursor.

IMMT_MOUSE
NC score	0.062411 (rank : 1805)	θ value	θ > 10 (rank : 1834)
Query Neighborhood Hits	1580	Target Neighborhood Hits	326	Shared Neighborhood Hits	160
SwissProt Accessions	Q8CAQ8, Q66JS4, Q7TNE2, Q8C7V1, Q8CCI0, Q8CDA8, Q9D9F6	Gene names	Immt
Domain Architecture	No domain graphic available
Description	Mitochondrial inner membrane protein (Mitofilin).

ABI2_HUMAN
NC score	0.062296 (rank : 1806)	θ value	6.88961 (rank : 1476)
Query Neighborhood Hits	1580	Target Neighborhood Hits	350	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

SDPR_MOUSE
NC score	0.062106 (rank : 1807)	θ value	θ > 10 (rank : 2074)
Query Neighborhood Hits	1580	Target Neighborhood Hits	485	Shared Neighborhood Hits	167
SwissProt Accessions	Q63918, Q3V1P6, Q78EC3, Q8CBT4	Gene names	Sdpr, Sdr
Domain Architecture	No domain graphic available
Description	Serum deprivation-response protein (Phosphatidylserine-binding protein).

KIF11_HUMAN
NC score	0.062071 (rank : 1808)	θ value	θ > 10 (rank : 1856)
Query Neighborhood Hits	1580	Target Neighborhood Hits	583	Shared Neighborhood Hits	243
SwissProt Accessions	P52732, Q15716, Q5VWX0	Gene names	KIF11, EG5, KNSL1
Domain Architecture
Description	Kinesin-like protein KIF11 (Kinesin-related motor protein Eg5) (Kinesin-like spindle protein HKSP) (Thyroid receptor-interacting protein 5) (TRIP5) (Kinesin-like protein 1).

SAFB2_HUMAN
NC score	0.062018 (rank : 1809)	θ value	θ > 10 (rank : 2072)
Query Neighborhood Hits	1580	Target Neighborhood Hits	720	Shared Neighborhood Hits	213
SwissProt Accessions	Q14151, Q8TB13	Gene names	SAFB2, KIAA0138
Domain Architecture
Description	Scaffold attachment factor B2.

AHI1_HUMAN
NC score	0.061987 (rank : 1810)	θ value	0.365318 (rank : 1202)
Query Neighborhood Hits	1580	Target Neighborhood Hits	537	Shared Neighborhood Hits	121
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ES8L2_MOUSE
NC score	0.061907 (rank : 1811)	θ value	0.0148317 (rank : 1046)
Query Neighborhood Hits	1580	Target Neighborhood Hits	169	Shared Neighborhood Hits	82
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

DIAP1_MOUSE
NC score	0.061888 (rank : 1812)	θ value	θ > 10 (rank : 1753)
Query Neighborhood Hits	1580	Target Neighborhood Hits	839	Shared Neighborhood Hits	283
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

TARSH_HUMAN
NC score	0.061876 (rank : 1813)	θ value	θ > 10 (rank : 2149)
Query Neighborhood Hits	1580	Target Neighborhood Hits	768	Shared Neighborhood Hits	159
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

IRPL1_MOUSE
NC score	0.061824 (rank : 1814)	θ value	θ > 10 (rank : 1839)
Query Neighborhood Hits	1580	Target Neighborhood Hits	186	Shared Neighborhood Hits	135
SwissProt Accessions	P59823	Gene names	Il1rapl1
Domain Architecture	No domain graphic available
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1).

U2AFM_MOUSE
NC score	0.061792 (rank : 1815)	θ value	θ > 10 (rank : 2186)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	205
SwissProt Accessions	Q62377	Gene names	Zrsr2, U2af1-rs2, U2af1l2, U2af1rs2
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 2 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2).

CTTB2_HUMAN
NC score	0.061784 (rank : 1816)	θ value	θ > 10 (rank : 1735)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1061	Shared Neighborhood Hits	310
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

MAP1B_MOUSE
NC score	0.061678 (rank : 1817)	θ value	θ > 10 (rank : 1907)
Query Neighborhood Hits	1580	Target Neighborhood Hits	977	Shared Neighborhood Hits	254
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

GCP60_HUMAN
NC score	0.061580 (rank : 1818)	θ value	θ > 10 (rank : 1788)
Query Neighborhood Hits	1580	Target Neighborhood Hits	419	Shared Neighborhood Hits	169
SwissProt Accessions	Q9H3P7, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3	Gene names	ACBD3, GCP60
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

TNNT3_HUMAN
NC score	0.061544 (rank : 1819)	θ value	θ > 10 (rank : 2162)
Query Neighborhood Hits	1580	Target Neighborhood Hits	327	Shared Neighborhood Hits	158
SwissProt Accessions	P45378, Q12975, Q12976, Q12977, Q12978, Q86TH6	Gene names	TNNT3
Domain Architecture	No domain graphic available
Description	Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT) (Beta TnTF).

PACN3_MOUSE
NC score	0.061447 (rank : 1820)	θ value	θ > 10 (rank : 1996)
Query Neighborhood Hits	1580	Target Neighborhood Hits	380	Shared Neighborhood Hits	186
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SRC8_HUMAN
NC score	0.061440 (rank : 1821)	θ value	θ > 10 (rank : 2115)
Query Neighborhood Hits	1580	Target Neighborhood Hits	269	Shared Neighborhood Hits	102
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

PKHA6_MOUSE
NC score	0.061439 (rank : 1822)	θ value	θ > 10 (rank : 2015)
Query Neighborhood Hits	1580	Target Neighborhood Hits	591	Shared Neighborhood Hits	190
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

LAMA2_HUMAN
NC score	0.061427 (rank : 1823)	θ value	θ > 10 (rank : 1874)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1092	Shared Neighborhood Hits	273
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

SHE_HUMAN
NC score	0.061337 (rank : 1824)	θ value	θ > 10 (rank : 2094)
Query Neighborhood Hits	1580	Target Neighborhood Hits	164	Shared Neighborhood Hits	58
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

GBP4_HUMAN
NC score	0.061250 (rank : 1825)	θ value	θ > 10 (rank : 1786)
Query Neighborhood Hits	1580	Target Neighborhood Hits	484	Shared Neighborhood Hits	201
SwissProt Accessions	Q96PP9, Q86T99	Gene names	GBP4
Domain Architecture
Description	Guanylate-binding protein 4 (GTP-binding protein 4) (Guanine nucleotide-binding protein 4) (GBP-4).

MOX2R_MOUSE
NC score	0.061225 (rank : 1826)	θ value	8.99809 (rank : 1549)
Query Neighborhood Hits	1580	Target Neighborhood Hits	110	Shared Neighborhood Hits	88
SwissProt Accessions	Q9ES57	Gene names	Cd200r1, Mox2r, Ox2r
Domain Architecture	No domain graphic available
Description	Cell surface glycoprotein OX2 receptor precursor (CD200 cell surface glycoprotein receptor).

ACINU_MOUSE
NC score	0.061005 (rank : 1827)	θ value	θ > 10 (rank : 1590)
Query Neighborhood Hits	1580	Target Neighborhood Hits	712	Shared Neighborhood Hits	223
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

SH3G1_HUMAN
NC score	0.060980 (rank : 1828)	θ value	θ > 10 (rank : 2082)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	137
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

CROP_HUMAN
NC score	0.060863 (rank : 1829)	θ value	θ > 10 (rank : 1724)
Query Neighborhood Hits	1580	Target Neighborhood Hits	402	Shared Neighborhood Hits	167
SwissProt Accessions	O95232, Q6PHR9, Q9NUY0, Q9P2S7	Gene names	CROP, CREAP1, O48
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein (cAMP regulatory element-associated protein 1) (CRE-associated protein 1) (CREAP-1) (Luc7A) (Okadaic acid-inducible phosphoprotein OA48-18).

NUCB1_MOUSE
NC score	0.060861 (rank : 1830)	θ value	θ > 10 (rank : 1975)
Query Neighborhood Hits	1580	Target Neighborhood Hits	414	Shared Neighborhood Hits	183
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

SH3G2_MOUSE
NC score	0.060823 (rank : 1831)	θ value	θ > 10 (rank : 2085)
Query Neighborhood Hits	1580	Target Neighborhood Hits	319	Shared Neighborhood Hits	141
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

RILP_MOUSE
NC score	0.060808 (rank : 1832)	θ value	θ > 10 (rank : 2061)
Query Neighborhood Hits	1580	Target Neighborhood Hits	257	Shared Neighborhood Hits	142
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

HCLS1_HUMAN
NC score	0.060755 (rank : 1833)	θ value	θ > 10 (rank : 1810)
Query Neighborhood Hits	1580	Target Neighborhood Hits	358	Shared Neighborhood Hits	108
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

DOT1L_HUMAN
NC score	0.060743 (rank : 1834)	θ value	0.00228821 (rank : 981)
Query Neighborhood Hits	1580	Target Neighborhood Hits	660	Shared Neighborhood Hits	176
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

BAP29_HUMAN
NC score	0.060690 (rank : 1835)	θ value	θ > 10 (rank : 1618)
Query Neighborhood Hits	1580	Target Neighborhood Hits	362	Shared Neighborhood Hits	168
SwissProt Accessions	Q9UHQ4, O95003	Gene names	BCAP29, BAP29
Domain Architecture
Description	B-cell receptor-associated protein 29 (BCR-associated protein Bap29).

KI21A_MOUSE
NC score	0.060673 (rank : 1836)	θ value	0.365318 (rank : 1209)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1317	Shared Neighborhood Hits	318
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

K0494_MOUSE
NC score	0.060585 (rank : 1837)	θ value	θ > 10 (rank : 1850)
Query Neighborhood Hits	1580	Target Neighborhood Hits	241	Shared Neighborhood Hits	133
SwissProt Accessions	Q8BGQ6, Q3TQN6, Q8BJV7, Q8C0R1	Gene names	Kiaa0494
Domain Architecture	No domain graphic available
Description	Uncharacterized calcium-binding protein KIAA0494.

DTBP1_MOUSE
NC score	0.060419 (rank : 1838)	θ value	4.03905 (rank : 1426)
Query Neighborhood Hits	1580	Target Neighborhood Hits	209	Shared Neighborhood Hits	127
SwissProt Accessions	Q91WZ8, Q80ZN4	Gene names	Dtnbp1
Domain Architecture
Description	Dystrobrevin-binding protein 1 (Dysbindin) (Hermansky-Pudlak syndrome 7 protein homolog).

STMN1_HUMAN
NC score	0.060383 (rank : 1839)	θ value	θ > 10 (rank : 2130)
Query Neighborhood Hits	1580	Target Neighborhood Hits	554	Shared Neighborhood Hits	204
SwissProt Accessions	P16949	Gene names	STMN1, LAP18, OP18
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Protein Pr22).

ES8L3_MOUSE
NC score	0.060328 (rank : 1840)	θ value	6.88961 (rank : 1485)
Query Neighborhood Hits	1580	Target Neighborhood Hits	168	Shared Neighborhood Hits	84
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

CAR10_MOUSE
NC score	0.060224 (rank : 1841)	θ value	θ > 10 (rank : 1641)
Query Neighborhood Hits	1580	Target Neighborhood Hits	407	Shared Neighborhood Hits	202
SwissProt Accessions	P58660	Gene names	Card10, Bimp1
Domain Architecture
Description	Caspase recruitment domain-containing protein 10 (Bcl10-interacting MAGUK protein 1) (Bimp1).

FLNC_HUMAN
NC score	0.060212 (rank : 1842)	θ value	θ > 10 (rank : 1780)
Query Neighborhood Hits	1580	Target Neighborhood Hits	116	Shared Neighborhood Hits	42
SwissProt Accessions	Q14315, O95303, Q07985, Q9NS12, Q9NYE5, Q9UMR8, Q9Y503	Gene names	FLNC, ABPL, FLN2
Domain Architecture
Description	Filamin-C (Gamma-filamin) (Filamin-2) (Protein FLNc) (Actin-binding- like protein) (ABP-L) (ABP-280-like protein).

CTGE4_HUMAN
NC score	0.060112 (rank : 1843)	θ value	θ > 10 (rank : 1732)
Query Neighborhood Hits	1580	Target Neighborhood Hits	393	Shared Neighborhood Hits	187
SwissProt Accessions	Q8IX94, O95046	Gene names	CTAGE4
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 4 (cTAGE-4 protein).

PVRL3_MOUSE
NC score	0.060054 (rank : 1844)	θ value	θ > 10 (rank : 2039)
Query Neighborhood Hits	1580	Target Neighborhood Hits	212	Shared Neighborhood Hits	130
SwissProt Accessions	Q9JLB9, Q9D006, Q9JLB7, Q9JLB8	Gene names	Pvrl3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Cell adhesion molecule nectin-3) (Nectin-3) (CDw113 antigen).

SH3G1_MOUSE
NC score	0.060047 (rank : 1845)	θ value	θ > 10 (rank : 2083)
Query Neighborhood Hits	1580	Target Neighborhood Hits	291	Shared Neighborhood Hits	128
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

UNC5D_MOUSE
NC score	0.059927 (rank : 1846)	θ value	θ > 10 (rank : 2192)
Query Neighborhood Hits	1580	Target Neighborhood Hits	268	Shared Neighborhood Hits	157
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

IRPL1_HUMAN
NC score	0.059860 (rank : 1847)	θ value	θ > 10 (rank : 1838)
Query Neighborhood Hits	1580	Target Neighborhood Hits	196	Shared Neighborhood Hits	135
SwissProt Accessions	Q9NZN1, Q9UJ53	Gene names	IL1RAPL1, OPHN4
Domain Architecture
Description	X-linked interleukin-1 receptor accessory protein-like 1 precursor (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2).

ITB4_HUMAN
NC score	0.059845 (rank : 1848)	θ value	θ > 10 (rank : 1842)
Query Neighborhood Hits	1580	Target Neighborhood Hits	458	Shared Neighborhood Hits	124
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

PCQAP_MOUSE
NC score	0.059751 (rank : 1849)	θ value	θ > 10 (rank : 1997)
Query Neighborhood Hits	1580	Target Neighborhood Hits	506	Shared Neighborhood Hits	162
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PLCB1_HUMAN
NC score	0.059694 (rank : 1850)	θ value	6.88961 (rank : 1506)
Query Neighborhood Hits	1580	Target Neighborhood Hits	614	Shared Neighborhood Hits	227
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

MYO7A_MOUSE
NC score	0.059511 (rank : 1851)	θ value	θ > 10 (rank : 1949)
Query Neighborhood Hits	1580	Target Neighborhood Hits	235	Shared Neighborhood Hits	96
SwissProt Accessions	P97479	Gene names	Myo7a, Myo7
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

IL1R2_MOUSE
NC score	0.059467 (rank : 1852)	θ value	θ > 10 (rank : 1830)
Query Neighborhood Hits	1580	Target Neighborhood Hits	125	Shared Neighborhood Hits	91
SwissProt Accessions	P27931	Gene names	Il1r2, Il-1r2, Il1rb
Domain Architecture
Description	Interleukin-1 receptor type II precursor (IL-1R-2) (IL-1R-beta) (CD121b antigen).

CDC37_MOUSE
NC score	0.059460 (rank : 1853)	θ value	θ > 10 (rank : 1672)
Query Neighborhood Hits	1580	Target Neighborhood Hits	359	Shared Neighborhood Hits	169
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CROP_MOUSE
NC score	0.059396 (rank : 1854)	θ value	θ > 10 (rank : 1725)
Query Neighborhood Hits	1580	Target Neighborhood Hits	403	Shared Neighborhood Hits	164
SwissProt Accessions	Q5SUF2, Q3U9D5, Q8BUJ5, Q921Z3, Q9CRS7, Q9CTY4	Gene names	Crop
Domain Architecture	No domain graphic available
Description	Cisplatin resistance-associated overexpressed protein.

USH2A_HUMAN
NC score	0.059353 (rank : 1855)	θ value	θ > 10 (rank : 2193)
Query Neighborhood Hits	1580	Target Neighborhood Hits	600	Shared Neighborhood Hits	132
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

SRRM2_MOUSE
NC score	0.059335 (rank : 1856)	θ value	0.0961366 (rank : 1138)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1470	Shared Neighborhood Hits	243
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

UNC5D_HUMAN
NC score	0.059267 (rank : 1857)	θ value	θ > 10 (rank : 2191)
Query Neighborhood Hits	1580	Target Neighborhood Hits	267	Shared Neighborhood Hits	157
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

MERL_MOUSE
NC score	0.059209 (rank : 1858)	θ value	θ > 10 (rank : 1911)
Query Neighborhood Hits	1580	Target Neighborhood Hits	524	Shared Neighborhood Hits	223
SwissProt Accessions	P46662, Q8BR03	Gene names	Nf2, Nf-2
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin).

KALM_HUMAN
NC score	0.059191 (rank : 1859)	θ value	θ > 10 (rank : 1855)
Query Neighborhood Hits	1580	Target Neighborhood Hits	114	Shared Neighborhood Hits	59
SwissProt Accessions	P23352	Gene names	KAL1, ADMLX, KAL, KALIG1
Domain Architecture
Description	Anosmin-1 precursor (Kallmann syndrome protein) (Adhesion molecule- like X-linked).

MERL_HUMAN
NC score	0.059130 (rank : 1860)	θ value	θ > 10 (rank : 1910)
Query Neighborhood Hits	1580	Target Neighborhood Hits	532	Shared Neighborhood Hits	225
SwissProt Accessions	P35240, O95683, Q8WUJ2, Q969N0, Q969Q3, Q96T30, Q96T31, Q96T32, Q96T33, Q9BTW3, Q9UNG9, Q9UNH3, Q9UNH4	Gene names	NF2, SCH
Domain Architecture
Description	Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) (Schwannomerlin).

GCP60_MOUSE
NC score	0.059128 (rank : 1861)	θ value	θ > 10 (rank : 1789)
Query Neighborhood Hits	1580	Target Neighborhood Hits	395	Shared Neighborhood Hits	162
SwissProt Accessions	Q8BMP6, O35371	Gene names	Acbd3, Gcp60, Pap7
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

SHAN2_MOUSE
NC score	0.058994 (rank : 1862)	θ value	θ > 10 (rank : 2090)
Query Neighborhood Hits	1580	Target Neighborhood Hits	446	Shared Neighborhood Hits	129
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

LAMB1_HUMAN
NC score	0.058936 (rank : 1863)	θ value	θ > 10 (rank : 1877)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1018	Shared Neighborhood Hits	282
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

IDLC_MOUSE
NC score	0.058891 (rank : 1864)	θ value	θ > 10 (rank : 1823)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	156
SwissProt Accessions	Q8BVN8	Gene names	Dnali1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal).

SRC8_MOUSE
NC score	0.058886 (rank : 1865)	θ value	θ > 10 (rank : 2116)
Query Neighborhood Hits	1580	Target Neighborhood Hits	292	Shared Neighborhood Hits	102
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

RP1L1_HUMAN
NC score	0.058818 (rank : 1866)	θ value	θ > 10 (rank : 2066)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1072	Shared Neighborhood Hits	226
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

PVRL3_HUMAN
NC score	0.058763 (rank : 1867)	θ value	θ > 10 (rank : 2038)
Query Neighborhood Hits	1580	Target Neighborhood Hits	204	Shared Neighborhood Hits	125
SwissProt Accessions	Q9NQS3, Q6NVZ3, Q8WVU4, Q9BVA9, Q9Y412	Gene names	PVRL3, PRR3
Domain Architecture	No domain graphic available
Description	Poliovirus receptor-related protein 3 precursor (Nectin-3) (CDw113 antigen).

GFAP_HUMAN
NC score	0.058742 (rank : 1868)	θ value	θ > 10 (rank : 1790)
Query Neighborhood Hits	1580	Target Neighborhood Hits	723	Shared Neighborhood Hits	283
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

CILP1_HUMAN
NC score	0.058685 (rank : 1869)	θ value	θ > 10 (rank : 1699)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	144
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

PKHA5_HUMAN
NC score	0.058541 (rank : 1870)	θ value	θ > 10 (rank : 2013)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	163
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

KIFC3_HUMAN
NC score	0.058517 (rank : 1871)	θ value	θ > 10 (rank : 1864)
Query Neighborhood Hits	1580	Target Neighborhood Hits	619	Shared Neighborhood Hits	259
SwissProt Accessions	Q9BVG8, O75299, Q8IUT3, Q96HW6	Gene names	KIFC3
Domain Architecture
Description	Kinesin-like protein KIFC3.

SFR12_HUMAN
NC score	0.058471 (rank : 1872)	θ value	θ > 10 (rank : 2076)
Query Neighborhood Hits	1580	Target Neighborhood Hits	553	Shared Neighborhood Hits	162
SwissProt Accessions	Q8WXA9, Q86X37	Gene names	SFRS12, SRRP86
Domain Architecture
Description	Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich- splicing regulatory protein 86) (SRrp86) (Splicing regulatory protein 508) (SRrp508).

FLNB_MOUSE
NC score	0.058465 (rank : 1873)	θ value	4.03905 (rank : 1428)
Query Neighborhood Hits	1580	Target Neighborhood Hits	126	Shared Neighborhood Hits	41
SwissProt Accessions	Q80X90, Q8VHX4, Q8VHX7, Q99KY3	Gene names	Flnb
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (ABP- 280-like protein).

STMN1_MOUSE
NC score	0.058244 (rank : 1874)	θ value	θ > 10 (rank : 2131)
Query Neighborhood Hits	1580	Target Neighborhood Hits	560	Shared Neighborhood Hits	203
SwissProt Accessions	P54227	Gene names	Stmn1, Lag, Lap18, Pr22
Domain Architecture
Description	Stathmin (Phosphoprotein p19) (pp19) (Oncoprotein 18) (Op18) (Leukemia-associated phosphoprotein p18) (pp17) (Prosolin) (Metablastin) (Pr22 protein) (Leukemia-associated gene protein).

MYO15_MOUSE
NC score	0.058206 (rank : 1875)	θ value	θ > 10 (rank : 1932)
Query Neighborhood Hits	1580	Target Neighborhood Hits	467	Shared Neighborhood Hits	92
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

KIF23_HUMAN
NC score	0.058112 (rank : 1876)	θ value	θ > 10 (rank : 1858)
Query Neighborhood Hits	1580	Target Neighborhood Hits	618	Shared Neighborhood Hits	248
SwissProt Accessions	Q02241	Gene names	KIF23, KNSL5, MKLP1
Domain Architecture
Description	Kinesin-like protein KIF23 (Mitotic kinesin-like protein 1) (Kinesin- like protein 5).

PCLO_HUMAN
NC score	0.058077 (rank : 1877)	θ value	6.88961 (rank : 1502)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2046	Shared Neighborhood Hits	380
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

FBX41_MOUSE
NC score	0.058066 (rank : 1878)	θ value	θ > 10 (rank : 1772)
Query Neighborhood Hits	1580	Target Neighborhood Hits	430	Shared Neighborhood Hits	184
SwissProt Accessions	Q6NS60, Q6P7W4, Q6ZPG1	Gene names	Fbxo41, D6Ertd538e, Kiaa1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

ABI2_MOUSE
NC score	0.058023 (rank : 1879)	θ value	θ > 10 (rank : 1588)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	92
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

FLNB_HUMAN
NC score	0.057972 (rank : 1880)	θ value	θ > 10 (rank : 1779)
Query Neighborhood Hits	1580	Target Neighborhood Hits	111	Shared Neighborhood Hits	41
SwissProt Accessions	O75369, Q13706, Q8WXS9, Q8WXT0, Q8WXT1, Q8WXT2, Q9NRB5, Q9NT26, Q9UEV9	Gene names	FLNB, FLN1L, FLN3, TABP, TAP
Domain Architecture
Description	Filamin-B (FLN-B) (Beta-filamin) (Actin-binding-like protein) (Thyroid autoantigen) (Truncated actin-binding protein) (Truncated ABP) (ABP- 280 homolog) (ABP-278) (Filamin 3) (Filamin homolog 1) (Fh1).

EMIL2_HUMAN
NC score	0.057787 (rank : 1881)	θ value	θ > 10 (rank : 1761)
Query Neighborhood Hits	1580	Target Neighborhood Hits	573	Shared Neighborhood Hits	203
SwissProt Accessions	Q9BXX0, Q8NBH3, Q96JQ4	Gene names	EMILIN2
Domain Architecture
Description	EMILIN-2 precursor (Elastin microfibril interface-located protein 2) (Elastin microfibril interfacer 2) (Protein FOAP-10).

MYO15_HUMAN
NC score	0.057740 (rank : 1882)	θ value	6.88961 (rank : 1498)
Query Neighborhood Hits	1580	Target Neighborhood Hits	671	Shared Neighborhood Hits	114
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

WTAP_HUMAN
NC score	0.057723 (rank : 1883)	θ value	θ > 10 (rank : 2210)
Query Neighborhood Hits	1580	Target Neighborhood Hits	262	Shared Neighborhood Hits	138
SwissProt Accessions	Q15007, Q96T28, Q9BYJ7, Q9H4E2	Gene names	WTAP, KIAA0105
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

APOA1_MOUSE
NC score	0.057701 (rank : 1884)	θ value	θ > 10 (rank : 1611)
Query Neighborhood Hits	1580	Target Neighborhood Hits	210	Shared Neighborhood Hits	123
SwissProt Accessions	Q00623	Gene names	Apoa1
Domain Architecture
Description	Apolipoprotein A-I precursor (Apo-AI) (ApoA-I).

ZRF1_HUMAN
NC score	0.057650 (rank : 1885)	θ value	θ > 10 (rank : 2216)
Query Neighborhood Hits	1580	Target Neighborhood Hits	457	Shared Neighborhood Hits	172
SwissProt Accessions	Q99543	Gene names	ZRF1, DNAJC2, MPHOSPH11, MPP11
Domain Architecture
Description	Zuotin-related factor 1 (M-phase phosphoprotein 11).

MYO7A_HUMAN
NC score	0.057617 (rank : 1886)	θ value	θ > 10 (rank : 1948)
Query Neighborhood Hits	1580	Target Neighborhood Hits	209	Shared Neighborhood Hits	81
SwissProt Accessions	Q13402, P78427, Q13321, Q14785, Q92821, Q92822	Gene names	MYO7A, USH1B
Domain Architecture
Description	Myosin-7A (Myosin VIIa).

PLCB2_HUMAN
NC score	0.057617 (rank : 1887)	θ value	θ > 10 (rank : 2018)
Query Neighborhood Hits	1580	Target Neighborhood Hits	608	Shared Neighborhood Hits	240
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

CASC5_HUMAN
NC score	0.057608 (rank : 1888)	θ value	θ > 10 (rank : 1646)
Query Neighborhood Hits	1580	Target Neighborhood Hits	376	Shared Neighborhood Hits	171
SwissProt Accessions	Q8NG31, Q8NHE1, Q8WXA6, Q9HCK2, Q9NR92	Gene names	CASC5, KIAA1570
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein) (ALL1- fused gene from chromosome 15q14) (AF15q14) (D40/AF15q14 protein).

SRRM1_MOUSE
NC score	0.057533 (rank : 1889)	θ value	θ > 10 (rank : 2117)
Query Neighborhood Hits	1580	Target Neighborhood Hits	966	Shared Neighborhood Hits	176
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

PACN1_MOUSE
NC score	0.057503 (rank : 1890)	θ value	θ > 10 (rank : 1992)
Query Neighborhood Hits	1580	Target Neighborhood Hits	283	Shared Neighborhood Hits	123
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

SH3G3_MOUSE
NC score	0.057492 (rank : 1891)	θ value	θ > 10 (rank : 2087)
Query Neighborhood Hits	1580	Target Neighborhood Hits	236	Shared Neighborhood Hits	96
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

FLNA_HUMAN
NC score	0.057443 (rank : 1892)	θ value	θ > 10 (rank : 1777)
Query Neighborhood Hits	1580	Target Neighborhood Hits	138	Shared Neighborhood Hits	37
SwissProt Accessions	P21333	Gene names	FLNA, FLN, FLN1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

FLNA_MOUSE
NC score	0.057407 (rank : 1893)	θ value	θ > 10 (rank : 1778)
Query Neighborhood Hits	1580	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BTM8, O54934, Q7TQI1, Q8BLK1, Q8BTN7, Q8VHX5, Q8VHX8, Q99KQ2	Gene names	Flna, Fln, Fln1
Domain Architecture
Description	Filamin-A (Alpha-filamin) (Filamin-1) (Endothelial actin-binding protein) (Actin-binding protein 280) (ABP-280) (Nonmuscle filamin).

AHI1_MOUSE
NC score	0.057352 (rank : 1894)	θ value	0.813845 (rank : 1248)
Query Neighborhood Hits	1580	Target Neighborhood Hits	496	Shared Neighborhood Hits	108
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

BEGIN_HUMAN
NC score	0.057260 (rank : 1895)	θ value	θ > 10 (rank : 1623)
Query Neighborhood Hits	1580	Target Neighborhood Hits	454	Shared Neighborhood Hits	199
SwissProt Accessions	Q9BUH8, Q9NPU3, Q9P282	Gene names	BEGAIN, KIAA1446
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

ANR12_HUMAN
NC score	0.057163 (rank : 1896)	θ value	θ > 10 (rank : 1608)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1081	Shared Neighborhood Hits	253
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

SPC25_HUMAN
NC score	0.057119 (rank : 1897)	θ value	θ > 10 (rank : 2112)
Query Neighborhood Hits	1580	Target Neighborhood Hits	273	Shared Neighborhood Hits	148
SwissProt Accessions	Q9HBM1	Gene names	SPBC25, SPC25
Domain Architecture	No domain graphic available
Description	Kinetochore protein Spc25 (hSpc25).

CCD38_HUMAN
NC score	0.057064 (rank : 1898)	θ value	θ > 10 (rank : 1654)
Query Neighborhood Hits	1580	Target Neighborhood Hits	287	Shared Neighborhood Hits	152
SwissProt Accessions	Q502W7, Q8N835	Gene names	CCDC38
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 38.

SSNA1_MOUSE
NC score	0.057002 (rank : 1899)	θ value	θ > 10 (rank : 2120)
Query Neighborhood Hits	1580	Target Neighborhood Hits	182	Shared Neighborhood Hits	106
SwissProt Accessions	Q9JJ94	Gene names	Ssna1
Domain Architecture	No domain graphic available
Description	Sjoegren syndrome nuclear autoantigen 1 homolog.

GO45_HUMAN
NC score	0.056891 (rank : 1900)	θ value	θ > 10 (rank : 1796)
Query Neighborhood Hits	1580	Target Neighborhood Hits	189	Shared Neighborhood Hits	123
SwissProt Accessions	Q9H2G9, O15298, Q5T531, Q9GZX4	Gene names	BLZF1, JEM1
Domain Architecture	No domain graphic available
Description	Golgin 45 (Basic leucine zipper nuclear factor 1) (JEM-1) (p45 basic leucine-zipper nuclear factor).

NCF4_MOUSE
NC score	0.056788 (rank : 1901)	θ value	θ > 10 (rank : 1958)
Query Neighborhood Hits	1580	Target Neighborhood Hits	177	Shared Neighborhood Hits	66
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

HSH2D_HUMAN
NC score	0.056740 (rank : 1902)	θ value	θ > 10 (rank : 1820)
Query Neighborhood Hits	1580	Target Neighborhood Hits	159	Shared Neighborhood Hits	54
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

ES8L1_HUMAN
NC score	0.056681 (rank : 1903)	θ value	5.27518 (rank : 1450)
Query Neighborhood Hits	1580	Target Neighborhood Hits	162	Shared Neighborhood Hits	80
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

KIFC3_MOUSE
NC score	0.056668 (rank : 1904)	θ value	θ > 10 (rank : 1865)
Query Neighborhood Hits	1580	Target Neighborhood Hits	571	Shared Neighborhood Hits	247
SwissProt Accessions	O35231, Q91YQ2	Gene names	Kifc3
Domain Architecture
Description	Kinesin-like protein KIFC3.

CNOT3_MOUSE
NC score	0.056655 (rank : 1905)	θ value	θ > 10 (rank : 1715)
Query Neighborhood Hits	1580	Target Neighborhood Hits	504	Shared Neighborhood Hits	177
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

PIGR_MOUSE
NC score	0.056530 (rank : 1906)	θ value	θ > 10 (rank : 2010)
Query Neighborhood Hits	1580	Target Neighborhood Hits	214	Shared Neighborhood Hits	119
SwissProt Accessions	O70570	Gene names	Pigr
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) [Contains: Secretory component].

SPN90_HUMAN
NC score	0.056469 (rank : 1907)	θ value	θ > 10 (rank : 2113)
Query Neighborhood Hits	1580	Target Neighborhood Hits	157	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

GRB14_MOUSE
NC score	0.056348 (rank : 1908)	θ value	θ > 10 (rank : 1802)
Query Neighborhood Hits	1580	Target Neighborhood Hits	149	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

FBX41_HUMAN
NC score	0.056297 (rank : 1909)	θ value	θ > 10 (rank : 1771)
Query Neighborhood Hits	1580	Target Neighborhood Hits	475	Shared Neighborhood Hits	189
SwissProt Accessions	Q8TF61	Gene names	FBXO41, FBX41, KIAA1940
Domain Architecture	No domain graphic available
Description	F-box only protein 41.

ANM2_HUMAN
NC score	0.056233 (rank : 1910)	θ value	θ > 10 (rank : 1604)
Query Neighborhood Hits	1580	Target Neighborhood Hits	175	Shared Neighborhood Hits	78
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

KIF3A_HUMAN
NC score	0.056163 (rank : 1911)	θ value	θ > 10 (rank : 1859)
Query Neighborhood Hits	1580	Target Neighborhood Hits	704	Shared Neighborhood Hits	265
SwissProt Accessions	Q9Y496, Q86XE9, Q9Y6V4	Gene names	KIF3A, KIF3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

SSNA1_HUMAN
NC score	0.056073 (rank : 1912)	θ value	θ > 10 (rank : 2119)
Query Neighborhood Hits	1580	Target Neighborhood Hits	175	Shared Neighborhood Hits	97
SwissProt Accessions	O43805, Q6FG70, Q9BVW8	Gene names	SSNA1, NA14
Domain Architecture
Description	Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa).

PLCB1_MOUSE
NC score	0.056034 (rank : 1913)	θ value	8.99809 (rank : 1557)
Query Neighborhood Hits	1580	Target Neighborhood Hits	531	Shared Neighborhood Hits	216
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

CLUA1_HUMAN
NC score	0.055984 (rank : 1914)	θ value	θ > 10 (rank : 1709)
Query Neighborhood Hits	1580	Target Neighborhood Hits	236	Shared Neighborhood Hits	126
SwissProt Accessions	Q96AJ1, O75138, Q65ZA3, Q9H8R4, Q9H8T1	Gene names	CLUAP1, KIAA0643
Domain Architecture	No domain graphic available
Description	Clusterin-associated protein 1.

SRRM2_HUMAN
NC score	0.055975 (rank : 1915)	θ value	θ > 10 (rank : 2118)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1296	Shared Neighborhood Hits	217
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

DGKB_HUMAN
NC score	0.055609 (rank : 1916)	θ value	θ > 10 (rank : 1746)
Query Neighborhood Hits	1580	Target Neighborhood Hits	238	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Y6T7, O75241, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29	Gene names	DGKB, DAGK2, KIAA0718
Domain Architecture
Description	Diacylglycerol kinase beta (EC 2.7.1.107) (Diglyceride kinase beta) (DGK-beta) (DAG kinase beta) (90 kDa diacylglycerol kinase).

KIF3A_MOUSE
NC score	0.055593 (rank : 1917)	θ value	5.27518 (rank : 1459)
Query Neighborhood Hits	1580	Target Neighborhood Hits	715	Shared Neighborhood Hits	266
SwissProt Accessions	P28741	Gene names	Kif3a, Kif3
Domain Architecture
Description	Kinesin-like protein KIF3A (Microtubule plus end-directed kinesin motor 3A).

HCFC2_MOUSE
NC score	0.055536 (rank : 1918)	θ value	θ > 10 (rank : 1809)
Query Neighborhood Hits	1580	Target Neighborhood Hits	97	Shared Neighborhood Hits	79
SwissProt Accessions	Q9D968	Gene names	Hcfc2
Domain Architecture	No domain graphic available
Description	Host cell factor 2 (HCF-2) (C2 factor).

APS_HUMAN
NC score	0.055376 (rank : 1919)	θ value	θ > 10 (rank : 1615)
Query Neighborhood Hits	1580	Target Neighborhood Hits	162	Shared Neighborhood Hits	64
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ACINU_HUMAN
NC score	0.055290 (rank : 1920)	θ value	θ > 10 (rank : 1589)
Query Neighborhood Hits	1580	Target Neighborhood Hits	828	Shared Neighborhood Hits	225
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

TMCO3_HUMAN
NC score	0.055254 (rank : 1921)	θ value	θ > 10 (rank : 2155)
Query Neighborhood Hits	1580	Target Neighborhood Hits	238	Shared Neighborhood Hits	142
SwissProt Accessions	Q6UWJ1, Q5JSB1, Q6NUN1, Q8NG29, Q8TCI6, Q96EA6, Q9NWT2	Gene names	TMCO3, C13orf11
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domain-containing protein 3 precursor (Putative LAG1-interacting protein).

MPP10_HUMAN
NC score	0.055175 (rank : 1922)	θ value	θ > 10 (rank : 1925)
Query Neighborhood Hits	1580	Target Neighborhood Hits	306	Shared Neighborhood Hits	135
SwissProt Accessions	O00566	Gene names	MPHOSPH10, MPP10
Domain Architecture
Description	U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10).

JIP4_HUMAN
NC score	0.055172 (rank : 1923)	θ value	θ > 10 (rank : 1847)
Query Neighborhood Hits	1580	Target Neighborhood Hits	585	Shared Neighborhood Hits	226
SwissProt Accessions	O60271, O60905, Q3KQU8, Q3MKM7, Q86WC7, Q86WC8, Q8IZX7, Q96II0, Q9H811	Gene names	SPAG9, HSS, KIAA0516, MAPK8IP4, SYD1
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (Human lung cancer protein 6) (HLC-6) (Proliferation-inducing protein 6) (Sperm-specific protein) (Sperm surface protein) (Protein highly expressed in testis) (PHET) (Sunday driver 1).

CUTL2_MOUSE
NC score	0.055132 (rank : 1924)	θ value	θ > 10 (rank : 1738)
Query Neighborhood Hits	1580	Target Neighborhood Hits	771	Shared Neighborhood Hits	254
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

LAMC1_MOUSE
NC score	0.055055 (rank : 1925)	θ value	θ > 10 (rank : 1878)
Query Neighborhood Hits	1580	Target Neighborhood Hits	856	Shared Neighborhood Hits	259
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

PLVAP_MOUSE
NC score	0.055041 (rank : 1926)	θ value	θ > 10 (rank : 2024)
Query Neighborhood Hits	1580	Target Neighborhood Hits	210	Shared Neighborhood Hits	124
SwissProt Accessions	Q91VC4, Q99JB1	Gene names	Plvap, Pv1
Domain Architecture	No domain graphic available
Description	Plasmalemma vesicle-associated protein (Plasmalemma vesicle protein 1) (PV-1) (MECA-32 antigen).

GPS2_HUMAN
NC score	0.055000 (rank : 1927)	θ value	θ > 10 (rank : 1799)
Query Neighborhood Hits	1580	Target Neighborhood Hits	459	Shared Neighborhood Hits	151
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

AMRP_MOUSE
NC score	0.054997 (rank : 1928)	θ value	θ > 10 (rank : 1603)
Query Neighborhood Hits	1580	Target Neighborhood Hits	173	Shared Neighborhood Hits	109
SwissProt Accessions	P55302	Gene names	Lrpap1
Domain Architecture
Description	Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2- MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin-binding protein 44) (HBP-44).

USH2A_MOUSE
NC score	0.054978 (rank : 1929)	θ value	θ > 10 (rank : 2194)
Query Neighborhood Hits	1580	Target Neighborhood Hits	626	Shared Neighborhood Hits	137
SwissProt Accessions	Q2QI47, Q9JLP3	Gene names	Ush2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein homolog) (Usher syndrome type IIa protein homolog).

LRC27_HUMAN
NC score	0.054919 (rank : 1930)	θ value	θ > 10 (rank : 1892)
Query Neighborhood Hits	1580	Target Neighborhood Hits	710	Shared Neighborhood Hits	220
SwissProt Accessions	Q9C0I9, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21	Gene names	LRRC27, KIAA1674
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

BAZ2B_HUMAN
NC score	0.054841 (rank : 1931)	θ value	θ > 10 (rank : 1620)
Query Neighborhood Hits	1580	Target Neighborhood Hits	803	Shared Neighborhood Hits	239
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

MFAP3_HUMAN
NC score	0.054839 (rank : 1932)	θ value	0.813845 (rank : 1261)
Query Neighborhood Hits	1580	Target Neighborhood Hits	91	Shared Neighborhood Hits	82
SwissProt Accessions	P55082, Q9NXA7	Gene names	MFAP3
Domain Architecture
Description	Microfibril-associated glycoprotein 3 precursor.

K0831_MOUSE
NC score	0.054804 (rank : 1933)	θ value	θ > 10 (rank : 1853)
Query Neighborhood Hits	1580	Target Neighborhood Hits	277	Shared Neighborhood Hits	143
SwissProt Accessions	Q8CDJ3, Q69ZY1, Q6PFY6, Q8C6N0, Q8R3M3	Gene names	Kiaa0831, D14Ertd436e
Domain Architecture	No domain graphic available
Description	Protein KIAA0831.

RIMB2_MOUSE
NC score	0.054781 (rank : 1934)	θ value	θ > 10 (rank : 2064)
Query Neighborhood Hits	1580	Target Neighborhood Hits	246	Shared Neighborhood Hits	115
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

ENAH_MOUSE
NC score	0.054762 (rank : 1935)	θ value	θ > 10 (rank : 1763)
Query Neighborhood Hits	1580	Target Neighborhood Hits	919	Shared Neighborhood Hits	268
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

RBNS5_MOUSE
NC score	0.054735 (rank : 1936)	θ value	θ > 10 (rank : 2054)
Query Neighborhood Hits	1580	Target Neighborhood Hits	266	Shared Neighborhood Hits	117
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

NOP14_HUMAN
NC score	0.054732 (rank : 1937)	θ value	θ > 10 (rank : 1971)
Query Neighborhood Hits	1580	Target Neighborhood Hits	573	Shared Neighborhood Hits	193
SwissProt Accessions	P78316, Q7LGI5, Q7Z6K0, Q8TBR6	Gene names	NOP14, C4orf9
Domain Architecture	No domain graphic available
Description	Probable nucleolar complex protein 14.

TAF7_HUMAN
NC score	0.054730 (rank : 1938)	θ value	θ > 10 (rank : 2147)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	136
SwissProt Accessions	Q15545, Q13036	Gene names	TAF7, TAF2F, TAFII55
Domain Architecture
Description	Transcription initiation factor TFIID subunit 7 (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55).

PKHA6_HUMAN
NC score	0.054641 (rank : 1939)	θ value	θ > 10 (rank : 2014)
Query Neighborhood Hits	1580	Target Neighborhood Hits	556	Shared Neighborhood Hits	169
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

GFAP_MOUSE
NC score	0.054561 (rank : 1940)	θ value	θ > 10 (rank : 1791)
Query Neighborhood Hits	1580	Target Neighborhood Hits	725	Shared Neighborhood Hits	270
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

SYCP3_HUMAN
NC score	0.054486 (rank : 1941)	θ value	θ > 10 (rank : 2139)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	138
SwissProt Accessions	Q8IZU3	Gene names	SYCP3, SCP3
Domain Architecture	No domain graphic available
Description	Synaptonemal complex protein 3 (SCP-3).

RBP1_HUMAN
NC score	0.054373 (rank : 1942)	θ value	θ > 10 (rank : 2055)
Query Neighborhood Hits	1580	Target Neighborhood Hits	521	Shared Neighborhood Hits	210
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

WTAP_MOUSE
NC score	0.054363 (rank : 1943)	θ value	θ > 10 (rank : 2211)
Query Neighborhood Hits	1580	Target Neighborhood Hits	250	Shared Neighborhood Hits	136
SwissProt Accessions	Q9ER69	Gene names	Wtap
Domain Architecture	No domain graphic available
Description	Wilms' tumor 1-associating protein (WT1-associated protein) (Putative pre-mRNA-splicing regulator female-lethal(2D) homolog).

KIFC1_HUMAN
NC score	0.054275 (rank : 1944)	θ value	θ > 10 (rank : 1863)
Query Neighborhood Hits	1580	Target Neighborhood Hits	545	Shared Neighborhood Hits	238
SwissProt Accessions	Q9BW19, O60887, Q14834, Q9UQP7	Gene names	KIFC1, HSET, KNSL2
Domain Architecture
Description	Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET).

PVRL1_HUMAN
NC score	0.054238 (rank : 1945)	θ value	θ > 10 (rank : 2037)
Query Neighborhood Hits	1580	Target Neighborhood Hits	219	Shared Neighborhood Hits	135
SwissProt Accessions	Q15223, O75465, Q9HBE6, Q9HBW2	Gene names	PVRL1, HVEC, PRR1
Domain Architecture
Description	Poliovirus receptor-related protein 1 precursor (Herpes virus entry mediator C) (HveC) (Nectin-1) (Herpesvirus Ig-like receptor) (HIgR) (CD111 antigen).

SDS3_HUMAN
NC score	0.054189 (rank : 1946)	θ value	θ > 10 (rank : 2075)
Query Neighborhood Hits	1580	Target Neighborhood Hits	257	Shared Neighborhood Hits	120
SwissProt Accessions	Q9H7L9, Q8N6H0, Q9H8D2	Gene names	SUDS3, SDS3
Domain Architecture	No domain graphic available
Description	Sin3 histone deacetylase corepressor complex component SDS3 (Suppressor of defective silencing 3 protein homolog).

IASPP_MOUSE
NC score	0.054174 (rank : 1947)	θ value	0.00390308 (rank : 1000)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1024	Shared Neighborhood Hits	173
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MYO1D_MOUSE
NC score	0.053987 (rank : 1948)	θ value	θ > 10 (rank : 1939)
Query Neighborhood Hits	1580	Target Neighborhood Hits	57	Shared Neighborhood Hits	28
SwissProt Accessions	Q5SYD0, Q5SSK7, Q8BWY5	Gene names	Myo1d
Domain Architecture	No domain graphic available
Description	Myosin Id.

MYO1D_HUMAN
NC score	0.053938 (rank : 1949)	θ value	θ > 10 (rank : 1938)
Query Neighborhood Hits	1580	Target Neighborhood Hits	56	Shared Neighborhood Hits	28
SwissProt Accessions	O94832, Q8NHP9	Gene names	MYO1D, KIAA0727
Domain Architecture
Description	Myosin Id.

CT075_HUMAN
NC score	0.053875 (rank : 1950)	θ value	θ > 10 (rank : 1726)
Query Neighborhood Hits	1580	Target Neighborhood Hits	387	Shared Neighborhood Hits	103
SwissProt Accessions	Q8WUT4, Q5JWV6, Q9H419	Gene names	C20orf75
Domain Architecture
Description	Uncharacterized protein C20orf75 precursor.

A20A4_HUMAN
NC score	0.053763 (rank : 1951)	θ value	θ > 10 (rank : 1586)
Query Neighborhood Hits	1580	Target Neighborhood Hits	710	Shared Neighborhood Hits	236
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

VIME_MOUSE
NC score	0.053673 (rank : 1952)	θ value	θ > 10 (rank : 2198)
Query Neighborhood Hits	1580	Target Neighborhood Hits	716	Shared Neighborhood Hits	275
SwissProt Accessions	P20152, O08704, Q8CCH1	Gene names	Vim
Domain Architecture
Description	Vimentin.

MYO1C_MOUSE
NC score	0.053649 (rank : 1953)	θ value	θ > 10 (rank : 1937)
Query Neighborhood Hits	1580	Target Neighborhood Hits	63	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WTI7, O08571, O08834, Q9QW54	Gene names	Myo1c
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMIb).

MYO1C_HUMAN
NC score	0.053631 (rank : 1954)	θ value	θ > 10 (rank : 1936)
Query Neighborhood Hits	1580	Target Neighborhood Hits	65	Shared Neighborhood Hits	28
SwissProt Accessions	O00159	Gene names	MYO1C
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMI-beta) (MMIb).

ABI1_MOUSE
NC score	0.053553 (rank : 1955)	θ value	6.88961 (rank : 1475)
Query Neighborhood Hits	1580	Target Neighborhood Hits	246	Shared Neighborhood Hits	94
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

RNF8_HUMAN
NC score	0.053534 (rank : 1956)	θ value	6.88961 (rank : 1510)
Query Neighborhood Hits	1580	Target Neighborhood Hits	622	Shared Neighborhood Hits	198
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

STMN2_HUMAN
NC score	0.053512 (rank : 1957)	θ value	θ > 10 (rank : 2132)
Query Neighborhood Hits	1580	Target Neighborhood Hits	458	Shared Neighborhood Hits	195
SwissProt Accessions	Q93045, O14952, Q6PK68	Gene names	STMN2, SCG10, SCGN10
Domain Architecture
Description	Stathmin-2 (SCG10 protein) (Superior cervical ganglion-10 protein).

STMN2_MOUSE
NC score	0.053512 (rank : 1958)	θ value	θ > 10 (rank : 2133)
Query Neighborhood Hits	1580	Target Neighborhood Hits	458	Shared Neighborhood Hits	195
SwissProt Accessions	P55821	Gene names	Stmn2, Scg10, Scgn10, Stmb2
Domain Architecture
Description	Stathmin-2 (SCG10 protein) (Superior cervical ganglion-10 protein).

IL1R1_HUMAN
NC score	0.053463 (rank : 1959)	θ value	θ > 10 (rank : 1828)
Query Neighborhood Hits	1580	Target Neighborhood Hits	140	Shared Neighborhood Hits	107
SwissProt Accessions	P14778	Gene names	IL1R1, IL1R, IL1RA, IL1RT1
Domain Architecture
Description	Interleukin-1 receptor type I precursor (IL-1R-1) (IL-1RT1) (IL-1R- alpha) (p80) (CD121a antigen).

TAF7_MOUSE
NC score	0.053391 (rank : 1960)	θ value	θ > 10 (rank : 2148)
Query Neighborhood Hits	1580	Target Neighborhood Hits	217	Shared Neighborhood Hits	127
SwissProt Accessions	Q9R1C0	Gene names	Taf7, Taf2f
Domain Architecture
Description	Transcription initiation factor TFIID subunit 7 (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55).

CT116_MOUSE
NC score	0.053333 (rank : 1961)	θ value	θ > 10 (rank : 1728)
Query Neighborhood Hits	1580	Target Neighborhood Hits	268	Shared Neighborhood Hits	124
SwissProt Accessions	Q80WW9, Q9CT52	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf116 homolog precursor.

MYO1B_HUMAN
NC score	0.053319 (rank : 1962)	θ value	θ > 10 (rank : 1934)
Query Neighborhood Hits	1580	Target Neighborhood Hits	70	Shared Neighborhood Hits	33
SwissProt Accessions	O43795, O43794, Q7Z6L5	Gene names	MYO1B
Domain Architecture	No domain graphic available
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MYH-1c).

FNBP2_HUMAN
NC score	0.053313 (rank : 1963)	θ value	θ > 10 (rank : 1781)
Query Neighborhood Hits	1580	Target Neighborhood Hits	432	Shared Neighborhood Hits	178
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

MYO1A_HUMAN
NC score	0.053280 (rank : 1964)	θ value	θ > 10 (rank : 1933)
Query Neighborhood Hits	1580	Target Neighborhood Hits	67	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBC5, Q9UQD7	Gene names	MYO1A, MYHL
Domain Architecture
Description	Myosin Ia (Brush border myosin I) (BBM-I) (BBMI) (Myosin I heavy chain) (MIHC).

IL6RB_MOUSE
NC score	0.053133 (rank : 1965)	θ value	θ > 10 (rank : 1832)
Query Neighborhood Hits	1580	Target Neighborhood Hits	168	Shared Neighborhood Hits	88
SwissProt Accessions	Q00560	Gene names	Il6st
Domain Architecture
Description	Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen).

MYO1B_MOUSE
NC score	0.053064 (rank : 1966)	θ value	θ > 10 (rank : 1935)
Query Neighborhood Hits	1580	Target Neighborhood Hits	71	Shared Neighborhood Hits	31
SwissProt Accessions	P46735, P70244	Gene names	Myo1b
Domain Architecture
Description	Myosin Ib (Myosin I alpha) (MMI-alpha) (MMIa) (MIH-L).

PECA1_MOUSE
NC score	0.053034 (rank : 1967)	θ value	θ > 10 (rank : 2000)
Query Neighborhood Hits	1580	Target Neighborhood Hits	126	Shared Neighborhood Hits	86
SwissProt Accessions	Q08481	Gene names	Pecam1, Pecam, Pecam-1
Domain Architecture
Description	Platelet endothelial cell adhesion molecule precursor (PECAM-1) (CD31 antigen).

CCAR1_HUMAN
NC score	0.052973 (rank : 1968)	θ value	θ > 10 (rank : 1647)
Query Neighborhood Hits	1580	Target Neighborhood Hits	444	Shared Neighborhood Hits	177
SwissProt Accessions	Q8IX12, Q32NE3, Q5VUP6, Q6PIZ0, Q6X935, Q9H8N4, Q9NVA7, Q9NVQ0, Q9NWM6	Gene names	CCAR1, CARP1, DIS
Domain Architecture	No domain graphic available
Description	Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain).

RIMB2_HUMAN
NC score	0.052874 (rank : 1969)	θ value	θ > 10 (rank : 2063)
Query Neighborhood Hits	1580	Target Neighborhood Hits	263	Shared Neighborhood Hits	114
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SHB_MOUSE
NC score	0.052860 (rank : 1970)	θ value	θ > 10 (rank : 2092)
Query Neighborhood Hits	1580	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

CT151_HUMAN
NC score	0.052746 (rank : 1971)	θ value	θ > 10 (rank : 1729)
Query Neighborhood Hits	1580	Target Neighborhood Hits	382	Shared Neighborhood Hits	148
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

MFAP3_MOUSE
NC score	0.052649 (rank : 1972)	θ value	2.36792 (rank : 1361)
Query Neighborhood Hits	1580	Target Neighborhood Hits	97	Shared Neighborhood Hits	82
SwissProt Accessions	Q922T2, Q8BHK5	Gene names	Mfap3
Domain Architecture	No domain graphic available
Description	Microfibril-associated glycoprotein 3 precursor.

CHCH3_MOUSE
NC score	0.052644 (rank : 1973)	θ value	θ > 10 (rank : 1694)
Query Neighborhood Hits	1580	Target Neighborhood Hits	249	Shared Neighborhood Hits	121
SwissProt Accessions	Q9CRB9	Gene names	Chchd3
Domain Architecture	No domain graphic available
Description	Coiled-coil-helix-coiled-coil-helix domain-containing protein 3.

LAMA4_MOUSE
NC score	0.052564 (rank : 1974)	θ value	0.62314 (rank : 1241)
Query Neighborhood Hits	1580	Target Neighborhood Hits	584	Shared Neighborhood Hits	193
SwissProt Accessions	P97927, O88785, P70409	Gene names	Lama4
Domain Architecture
Description	Laminin alpha-4 chain precursor.

PCLO_MOUSE
NC score	0.052541 (rank : 1975)	θ value	6.88961 (rank : 1503)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2275	Shared Neighborhood Hits	372
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CEP72_HUMAN
NC score	0.052502 (rank : 1976)	θ value	θ > 10 (rank : 1688)
Query Neighborhood Hits	1580	Target Neighborhood Hits	374	Shared Neighborhood Hits	161
SwissProt Accessions	Q9P209, Q9BV03, Q9BWM3, Q9NVR4	Gene names	CEP72, KIAA1519
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 72 kDa (Cep72 protein).

BEGIN_MOUSE
NC score	0.052423 (rank : 1977)	θ value	θ > 10 (rank : 1624)
Query Neighborhood Hits	1580	Target Neighborhood Hits	383	Shared Neighborhood Hits	181
SwissProt Accessions	Q68EF6	Gene names	Begain
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

A20A1_HUMAN
NC score	0.052350 (rank : 1978)	θ value	θ > 10 (rank : 1583)
Query Neighborhood Hits	1580	Target Neighborhood Hits	698	Shared Neighborhood Hits	234
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

MICA3_MOUSE
NC score	0.052347 (rank : 1979)	θ value	θ > 10 (rank : 1919)
Query Neighborhood Hits	1580	Target Neighborhood Hits	104	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CJ19, Q80TE8, Q8BXB1	Gene names	Mical3, Kiaa1364
Domain Architecture
Description	Protein MICAL-3.

DGKG_MOUSE
NC score	0.052300 (rank : 1980)	θ value	θ > 10 (rank : 1749)
Query Neighborhood Hits	1580	Target Neighborhood Hits	188	Shared Neighborhood Hits	44
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

DGKG_HUMAN
NC score	0.051973 (rank : 1981)	θ value	θ > 10 (rank : 1748)
Query Neighborhood Hits	1580	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	P49619	Gene names	DGKG, DAGK3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma).

VIME_HUMAN
NC score	0.051968 (rank : 1982)	θ value	θ > 10 (rank : 2197)
Query Neighborhood Hits	1580	Target Neighborhood Hits	706	Shared Neighborhood Hits	277
SwissProt Accessions	P08670, Q15867, Q15868, Q15869, Q6LER9, Q8N850, Q96ML2, Q9NTM3	Gene names	VIM
Domain Architecture
Description	Vimentin.

LMO7_HUMAN
NC score	0.051928 (rank : 1983)	θ value	θ > 10 (rank : 1890)
Query Neighborhood Hits	1580	Target Neighborhood Hits	507	Shared Neighborhood Hits	155
SwissProt Accessions	Q8WWI1, O15462, O95346, Q9UKC1, Q9UQM5, Q9Y6A7	Gene names	LMO7, FBX20, FBXO20, KIAA0858
Domain Architecture
Description	LIM domain only protein 7 (LOMP) (F-box only protein 20).

GBP2_MOUSE
NC score	0.051813 (rank : 1984)	θ value	1.06291 (rank : 1280)
Query Neighborhood Hits	1580	Target Neighborhood Hits	323	Shared Neighborhood Hits	168
SwissProt Accessions	Q9Z0E6, Q8CIC6, Q921N2, Q9R1I0	Gene names	Gbp2
Domain Architecture
Description	Interferon-induced guanylate-binding protein 2 (GTP-binding protein 2) (Guanine nucleotide-binding protein 2) (GBP-2) (mGBP2) (mGBP-2).

LNK_HUMAN
NC score	0.051795 (rank : 1985)	θ value	θ > 10 (rank : 1891)
Query Neighborhood Hits	1580	Target Neighborhood Hits	151	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ANM2_MOUSE
NC score	0.051753 (rank : 1986)	θ value	θ > 10 (rank : 1605)
Query Neighborhood Hits	1580	Target Neighborhood Hits	175	Shared Neighborhood Hits	78
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

GRB14_HUMAN
NC score	0.051751 (rank : 1987)	θ value	θ > 10 (rank : 1801)
Query Neighborhood Hits	1580	Target Neighborhood Hits	137	Shared Neighborhood Hits	52
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

JIP4_MOUSE
NC score	0.051588 (rank : 1988)	θ value	θ > 10 (rank : 1848)
Query Neighborhood Hits	1580	Target Neighborhood Hits	593	Shared Neighborhood Hits	232
SwissProt Accessions	Q58A65, Q3UH77, Q3UHF0, Q58VQ4, Q5NC70, Q5NC78, Q6A057, Q6PAS3, Q8CJC2	Gene names	Spag9, Jip4, Jsap2, Kiaa0516, Mapk8ip4
Domain Architecture	No domain graphic available
Description	C-jun-amino-terminal kinase-interacting protein 4 (JNK-interacting protein 4) (JIP-4) (JNK-associated leucine-zipper protein) (JLP) (Sperm-associated antigen 9) (Mitogen-activated protein kinase 8- interacting protein 4) (JNK/SAPK-associated protein 2) (JSAP2).

AAT1_HUMAN
NC score	0.051548 (rank : 1989)	θ value	θ > 10 (rank : 1587)
Query Neighborhood Hits	1580	Target Neighborhood Hits	199	Shared Neighborhood Hits	114
SwissProt Accessions	Q7Z4T9, Q68DX2, Q8TD41, Q96A45, Q96JE8	Gene names	AAT1, C3orf15
Domain Architecture	No domain graphic available
Description	AMY-1-associating protein expressed in testis 1 (AAT-1).

BAP29_MOUSE
NC score	0.051547 (rank : 1990)	θ value	θ > 10 (rank : 1619)
Query Neighborhood Hits	1580	Target Neighborhood Hits	285	Shared Neighborhood Hits	146
SwissProt Accessions	Q61334	Gene names	Bcap29, Bap29
Domain Architecture
Description	B-cell receptor-associated protein 29 (BCR-associated protein Bap29).

PDL1_HUMAN
NC score	0.051468 (rank : 1991)	θ value	θ > 10 (rank : 1998)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	115
SwissProt Accessions	Q9NZQ7, Q66RK1, Q6WEX4, Q9NUZ5	Gene names	CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
Domain Architecture	No domain graphic available
Description	Programmed cell death 1 ligand 1 precursor (Programmed death ligand 1) (PD-L1) (PDCD1 ligand 1) (B7 homolog 1) (B7-H1) (CD274 antigen).

TBCD2_HUMAN
NC score	0.051464 (rank : 1992)	θ value	0.0736092 (rank : 1123)
Query Neighborhood Hits	1580	Target Neighborhood Hits	419	Shared Neighborhood Hits	161
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

MICA1_HUMAN
NC score	0.051335 (rank : 1993)	θ value	θ > 10 (rank : 1915)
Query Neighborhood Hits	1580	Target Neighborhood Hits	279	Shared Neighborhood Hits	106
SwissProt Accessions	Q8TDZ2, Q7Z633, Q8IVS9, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7	Gene names	MICAL1, MICAL, NICAL
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

NCF4_HUMAN
NC score	0.051328 (rank : 1994)	θ value	θ > 10 (rank : 1957)
Query Neighborhood Hits	1580	Target Neighborhood Hits	161	Shared Neighborhood Hits	52
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

TMCO3_MOUSE
NC score	0.051239 (rank : 1995)	θ value	θ > 10 (rank : 2156)
Query Neighborhood Hits	1580	Target Neighborhood Hits	241	Shared Neighborhood Hits	136
SwissProt Accessions	Q8BH01, Q3UFX1, Q7TMT5, Q8BGL4, Q8R303	Gene names	Tmco3
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domain-containing protein 3 precursor.

SURF6_MOUSE
NC score	0.051139 (rank : 1996)	θ value	θ > 10 (rank : 2136)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	104
SwissProt Accessions	P70279, Q8BPI4, Q8BRL7, Q8R0Q7	Gene names	Surf6, Surf-6
Domain Architecture
Description	Surfeit locus protein 6.

A20A2_HUMAN
NC score	0.051116 (rank : 1997)	θ value	θ > 10 (rank : 1584)
Query Neighborhood Hits	1580	Target Neighborhood Hits	716	Shared Neighborhood Hits	234
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

CNOT3_HUMAN
NC score	0.051089 (rank : 1998)	θ value	θ > 10 (rank : 1714)
Query Neighborhood Hits	1580	Target Neighborhood Hits	425	Shared Neighborhood Hits	164
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

RBP1_MOUSE
NC score	0.051080 (rank : 1999)	θ value	θ > 10 (rank : 2056)
Query Neighborhood Hits	1580	Target Neighborhood Hits	493	Shared Neighborhood Hits	210
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

A20A3_HUMAN
NC score	0.050996 (rank : 2000)	θ value	θ > 10 (rank : 1585)
Query Neighborhood Hits	1580	Target Neighborhood Hits	692	Shared Neighborhood Hits	229
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

SAFB2_MOUSE
NC score	0.050929 (rank : 2001)	θ value	θ > 10 (rank : 2073)
Query Neighborhood Hits	1580	Target Neighborhood Hits	581	Shared Neighborhood Hits	196
SwissProt Accessions	Q80YR5, Q8K153	Gene names	Safb2
Domain Architecture
Description	Scaffold attachment factor B2.

LAMA3_MOUSE
NC score	0.050848 (rank : 2002)	θ value	θ > 10 (rank : 1876)
Query Neighborhood Hits	1580	Target Neighborhood Hits	859	Shared Neighborhood Hits	239
SwissProt Accessions	Q61789, O08751, Q61788, Q61966, Q9JHQ7	Gene names	Lama3
Domain Architecture
Description	Laminin alpha-3 chain precursor (Nicein subunit alpha).

COCA1_MOUSE
NC score	0.050728 (rank : 2003)	θ value	θ > 10 (rank : 1717)
Query Neighborhood Hits	1580	Target Neighborhood Hits	467	Shared Neighborhood Hits	152
SwissProt Accessions	Q60847, P70322	Gene names	Col12a1
Domain Architecture
Description	Collagen alpha-1(XII) chain precursor.

STIM2_HUMAN
NC score	0.050710 (rank : 2004)	θ value	θ > 10 (rank : 2129)
Query Neighborhood Hits	1580	Target Neighborhood Hits	420	Shared Neighborhood Hits	195
SwissProt Accessions	Q9P246, Q96BF1, Q9BQH2, Q9H8R1	Gene names	STIM2, KIAA1482
Domain Architecture
Description	Stromal interaction molecule 2 precursor.

APOE_HUMAN
NC score	0.050687 (rank : 2005)	θ value	θ > 10 (rank : 1614)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	108
SwissProt Accessions	P02649, Q9P2S4	Gene names	APOE
Domain Architecture
Description	Apolipoprotein E precursor (Apo-E).

SH3G3_HUMAN
NC score	0.050672 (rank : 2006)	θ value	θ > 10 (rank : 2086)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	90
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

TS101_HUMAN
NC score	0.050662 (rank : 2007)	θ value	θ > 10 (rank : 2174)
Query Neighborhood Hits	1580	Target Neighborhood Hits	359	Shared Neighborhood Hits	158
SwissProt Accessions	Q99816, Q9BUM5	Gene names	TSG101
Domain Architecture
Description	Tumor susceptibility gene 101 protein.

MICA2_HUMAN
NC score	0.050627 (rank : 2008)	θ value	θ > 10 (rank : 1917)
Query Neighborhood Hits	1580	Target Neighborhood Hits	174	Shared Neighborhood Hits	38
SwissProt Accessions	O94851, Q7Z3A8	Gene names	MICAL2, KIAA0750
Domain Architecture
Description	Protein MICAL-2.

SHD_MOUSE
NC score	0.050611 (rank : 2009)	θ value	θ > 10 (rank : 2093)
Query Neighborhood Hits	1580	Target Neighborhood Hits	137	Shared Neighborhood Hits	58
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

PPIP2_MOUSE
NC score	0.050604 (rank : 2010)	θ value	θ > 10 (rank : 2028)
Query Neighborhood Hits	1580	Target Neighborhood Hits	308	Shared Neighborhood Hits	148
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

SIGL7_HUMAN
NC score	0.050557 (rank : 2011)	θ value	θ > 10 (rank : 2098)
Query Neighborhood Hits	1580	Target Neighborhood Hits	180	Shared Neighborhood Hits	132
SwissProt Accessions	Q9Y286, Q9NZQ1, Q9UJ86, Q9UJ87, Q9Y502	Gene names	SIGLEC7, AIRM1
Domain Architecture
Description	Sialic acid-binding Ig-like lectin 7 precursor (Siglec-7) (QA79 membrane protein) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (p75) (D-siglec) (CDw328 antigen).

RNF8_MOUSE
NC score	0.050553 (rank : 2012)	θ value	θ > 10 (rank : 2065)
Query Neighborhood Hits	1580	Target Neighborhood Hits	618	Shared Neighborhood Hits	200
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

K2C1_HUMAN
NC score	0.050380 (rank : 2013)	θ value	θ > 10 (rank : 1854)
Query Neighborhood Hits	1580	Target Neighborhood Hits	624	Shared Neighborhood Hits	239
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

AMGO2_HUMAN
NC score	0.050375 (rank : 2014)	θ value	0.365318 (rank : 1204)
Query Neighborhood Hits	1580	Target Neighborhood Hits	357	Shared Neighborhood Hits	123
SwissProt Accessions	Q86SJ2, Q7Z4A0, Q96CN8	Gene names	AMIGO2, ALI1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1) (Differentially expressed in gastric adenocarcinomas) (DEGA).

MICA3_HUMAN
NC score	0.050303 (rank : 2015)	θ value	θ > 10 (rank : 1918)
Query Neighborhood Hits	1580	Target Neighborhood Hits	160	Shared Neighborhood Hits	35
SwissProt Accessions	Q7RTP6, Q6ICK4, Q9P2I3	Gene names	MICAL3, KIAA1364
Domain Architecture
Description	Protein MICAL-3.

AFAD_HUMAN
NC score	0.050303 (rank : 2016)	θ value	θ > 10 (rank : 1597)
Query Neighborhood Hits	1580	Target Neighborhood Hits	689	Shared Neighborhood Hits	214
SwissProt Accessions	P55196, O75087, O75088, O75089, Q5TIG6, Q9NSN7, Q9NU92	Gene names	MLLT4, AF6
Domain Architecture
Description	Afadin (Protein AF-6).

NFH_MOUSE
NC score	0.050268 (rank : 2017)	θ value	0.000461057 (rank : 924)
Query Neighborhood Hits	1580	Target Neighborhood Hits	2247	Shared Neighborhood Hits	410
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

DIAP1_HUMAN
NC score	0.050257 (rank : 2018)	θ value	θ > 10 (rank : 1752)
Query Neighborhood Hits	1580	Target Neighborhood Hits	784	Shared Neighborhood Hits	274
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

IASPP_HUMAN
NC score	0.050118 (rank : 2019)	θ value	θ > 10 (rank : 1821)
Query Neighborhood Hits	1580	Target Neighborhood Hits	688	Shared Neighborhood Hits	141
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SHB_HUMAN
NC score	0.050041 (rank : 2020)	θ value	θ > 10 (rank : 2091)
Query Neighborhood Hits	1580	Target Neighborhood Hits	141	Shared Neighborhood Hits	57
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

KIF14_HUMAN
NC score	0.050033 (rank : 2021)	θ value	θ > 10 (rank : 1857)
Query Neighborhood Hits	1580	Target Neighborhood Hits	732	Shared Neighborhood Hits	273
SwissProt Accessions	Q15058	Gene names	KIF14, KIAA0042
Domain Architecture	No domain graphic available
Description	Kinesin-like protein KIF14.

ILRL2_MOUSE
NC score	0.050010 (rank : 2022)	θ value	4.03905 (rank : 1432)
Query Neighborhood Hits	1580	Target Neighborhood Hits	158	Shared Neighborhood Hits	123
SwissProt Accessions	Q9ERS7	Gene names	Il1rl2
Domain Architecture
Description	Interleukin-1 receptor-like 2 precursor (IL-1Rrp2).

PIGR_HUMAN
NC score	0.050004 (rank : 2023)	θ value	θ > 10 (rank : 2009)
Query Neighborhood Hits	1580	Target Neighborhood Hits	164	Shared Neighborhood Hits	88
SwissProt Accessions	P01833, Q8IZY7	Gene names	PIGR
Domain Architecture
Description	Polymeric-immunoglobulin receptor precursor (Poly-Ig receptor) (PIGR) (Hepatocellular carcinoma-associated protein TB6) [Contains: Secretory component].

CD276_MOUSE
NC score	0.049809 (rank : 2024)	θ value	8.99809 (rank : 1529)
Query Neighborhood Hits	1580	Target Neighborhood Hits	243	Shared Neighborhood Hits	134
SwissProt Accessions	Q8VE98	Gene names	Cd276, B7h3
Domain Architecture	No domain graphic available
Description	CD276 antigen precursor (Costimulatory molecule) (B7 homolog 3) (B7- H3).

HHLA2_HUMAN
NC score	0.049571 (rank : 2025)	θ value	2.36792 (rank : 1354)
Query Neighborhood Hits	1580	Target Neighborhood Hits	140	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UM44, Q9NWQ6	Gene names	HHLA2
Domain Architecture	No domain graphic available
Description	HERV-H LTR-associating protein 2 precursor (Human endogenous retrovirus-H long terminal repeat-associating protein 2).

AMPH_MOUSE
NC score	0.049487 (rank : 2026)	θ value	4.03905 (rank : 1417)
Query Neighborhood Hits	1580	Target Neighborhood Hits	291	Shared Neighborhood Hits	112
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

CHCH3_HUMAN
NC score	0.049347 (rank : 2027)	θ value	2.36792 (rank : 1349)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	110
SwissProt Accessions	Q9NX63	Gene names	CHCHD3
Domain Architecture	No domain graphic available
Description	Coiled-coil-helix-coiled-coil-helix domain-containing protein 3.

AMPH_HUMAN
NC score	0.048675 (rank : 2028)	θ value	1.81305 (rank : 1321)
Query Neighborhood Hits	1580	Target Neighborhood Hits	455	Shared Neighborhood Hits	135
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMGO2_MOUSE
NC score	0.047132 (rank : 2029)	θ value	0.0961366 (rank : 1127)
Query Neighborhood Hits	1580	Target Neighborhood Hits	329	Shared Neighborhood Hits	100
SwissProt Accessions	Q80ZD9	Gene names	Amigo2, Ali1
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 2 precursor (AMIGO-2) (Alivin-1).

NACAM_MOUSE
NC score	0.047071 (rank : 2030)	θ value	0.125558 (rank : 1150)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1866	Shared Neighborhood Hits	249
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

PVR_HUMAN
NC score	0.045976 (rank : 2031)	θ value	0.813845 (rank : 1265)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	104
SwissProt Accessions	P15151, P15152, Q15267, Q15268, Q96BJ1	Gene names	PVR, PVS
Domain Architecture
Description	Poliovirus receptor precursor (Nectin-like protein 5) (Necl-5) (CD155 antigen).

DAAM1_MOUSE
NC score	0.044805 (rank : 2032)	θ value	3.0926 (rank : 1386)
Query Neighborhood Hits	1580	Target Neighborhood Hits	443	Shared Neighborhood Hits	198
SwissProt Accessions	Q8BPM0, Q80Y68, Q9CQQ2	Gene names	Daam1
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

PEX13_HUMAN
NC score	0.044364 (rank : 2033)	θ value	8.99809 (rank : 1552)
Query Neighborhood Hits	1580	Target Neighborhood Hits	128	Shared Neighborhood Hits	62
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

AMGO1_HUMAN
NC score	0.043708 (rank : 2034)	θ value	3.0926 (rank : 1376)
Query Neighborhood Hits	1580	Target Neighborhood Hits	353	Shared Neighborhood Hits	96
SwissProt Accessions	Q86WK6, Q8IW71, Q9ULQ7	Gene names	AMIGO1, ALI2, AMIGO, KIAA1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

BIN1_MOUSE
NC score	0.043694 (rank : 2035)	θ value	0.0961366 (rank : 1130)
Query Neighborhood Hits	1580	Target Neighborhood Hits	283	Shared Neighborhood Hits	105
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

NFL_HUMAN
NC score	0.043677 (rank : 2036)	θ value	8.99809 (rank : 1550)
Query Neighborhood Hits	1580	Target Neighborhood Hits	666	Shared Neighborhood Hits	246
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

PVRL2_HUMAN
NC score	0.043476 (rank : 2037)	θ value	0.813845 (rank : 1264)
Query Neighborhood Hits	1580	Target Neighborhood Hits	185	Shared Neighborhood Hits	104
SwissProt Accessions	Q92692, O75455, Q96J29	Gene names	PVRL2, HVEB, PRR2
Domain Architecture
Description	Poliovirus receptor-related protein 2 precursor (Herpes virus entry mediator B) (HveB) (Nectin-2) (CD112 antigen).

EPS8_MOUSE
NC score	0.042432 (rank : 2038)	θ value	8.99809 (rank : 1537)
Query Neighborhood Hits	1580	Target Neighborhood Hits	157	Shared Neighborhood Hits	74
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

K1C9_HUMAN
NC score	0.042241 (rank : 2039)	θ value	0.21417 (rank : 1170)
Query Neighborhood Hits	1580	Target Neighborhood Hits	526	Shared Neighborhood Hits	234
SwissProt Accessions	P35527, O00109, Q14665	Gene names	KRT9
Domain Architecture
Description	Keratin, type I cytoskeletal 9 (Cytokeratin-9) (CK-9) (Keratin-9) (K9).

DAAM1_HUMAN
NC score	0.042046 (rank : 2040)	θ value	3.0926 (rank : 1385)
Query Neighborhood Hits	1580	Target Neighborhood Hits	483	Shared Neighborhood Hits	204
SwissProt Accessions	Q9Y4D1, Q86U34, Q8N1Z8, Q8TB39	Gene names	DAAM1, KIAA0666
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 1.

BAZ1A_HUMAN
NC score	0.042011 (rank : 2041)	θ value	5.27518 (rank : 1443)
Query Neighborhood Hits	1580	Target Neighborhood Hits	693	Shared Neighborhood Hits	226
SwissProt Accessions	Q9NRL2, Q9NZ15, Q9P065, Q9UIG1, Q9Y3V3	Gene names	BAZ1A, ACF1, WCRF180
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain protein 1A (ATP-utilizing chromatin assembly and remodeling factor 1) (hACF1) (ATP-dependent chromatin remodelling protein) (Williams syndrome transcription factor-related chromatin remodeling factor 180) (WCRF180) (hWALp1) (CHRAC subunit ACF1).

BIN1_HUMAN
NC score	0.041929 (rank : 2042)	θ value	0.0736092 (rank : 1112)
Query Neighborhood Hits	1580	Target Neighborhood Hits	335	Shared Neighborhood Hits	97
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

MLL2_HUMAN
NC score	0.041620 (rank : 2043)	θ value	2.36792 (rank : 1364)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1788	Shared Neighborhood Hits	322
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

KI20A_HUMAN
NC score	0.041170 (rank : 2044)	θ value	0.0961366 (rank : 1135)
Query Neighborhood Hits	1580	Target Neighborhood Hits	321	Shared Neighborhood Hits	160
SwissProt Accessions	O95235	Gene names	KIF20A, RAB6KIFL
Domain Architecture
Description	Kinesin family member 20A (Rabkinesin-6) (Rab6-interacting kinesin- like protein) (GG10_2).

AMGO3_MOUSE
NC score	0.040642 (rank : 2045)	θ value	3.0926 (rank : 1377)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	80
SwissProt Accessions	Q8C2S7, Q6ZPH1, Q8CEB3	Gene names	Amigo3, Ali3, Kiaa1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

AMGO3_HUMAN
NC score	0.040389 (rank : 2046)	θ value	8.99809 (rank : 1523)
Query Neighborhood Hits	1580	Target Neighborhood Hits	276	Shared Neighborhood Hits	82
SwissProt Accessions	Q86WK7, Q96JH6	Gene names	AMIGO3, ALI3, KIAA1851
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 3 precursor (AMIGO-3) (Alivin-3).

AMGO1_MOUSE
NC score	0.040211 (rank : 2047)	θ value	1.38821 (rank : 1296)
Query Neighborhood Hits	1580	Target Neighborhood Hits	325	Shared Neighborhood Hits	86
SwissProt Accessions	Q80ZD8, Q69ZQ0, Q8R5D4, Q921U9	Gene names	Amigo1, Ali2, Amigo, Kiaa1163
Domain Architecture	No domain graphic available
Description	Amphoterin-induced protein 1 precursor (AMIGO-1) (Alivin-2).

EPS8_HUMAN
NC score	0.040211 (rank : 2048)	θ value	8.99809 (rank : 1536)
Query Neighborhood Hits	1580	Target Neighborhood Hits	151	Shared Neighborhood Hits	71
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ZN318_HUMAN
NC score	0.038286 (rank : 2049)	θ value	2.36792 (rank : 1374)
Query Neighborhood Hits	1580	Target Neighborhood Hits	497	Shared Neighborhood Hits	155
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

MDC1_HUMAN
NC score	0.037684 (rank : 2050)	θ value	8.99809 (rank : 1547)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1446	Shared Neighborhood Hits	233
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

GBP5_MOUSE
NC score	0.037610 (rank : 2051)	θ value	0.279714 (rank : 1187)
Query Neighborhood Hits	1580	Target Neighborhood Hits	254	Shared Neighborhood Hits	124
SwissProt Accessions	Q8CFB4, Q8CFA4	Gene names	Gbp5
Domain Architecture
Description	Interferon-induced guanylate-binding protein 5 (GTP-binding protein 5) (Guanine nucleotide-binding protein 5) (GBP-5) (MuGBP-5).

KI20A_MOUSE
NC score	0.035844 (rank : 2052)	θ value	0.279714 (rank : 1193)
Query Neighborhood Hits	1580	Target Neighborhood Hits	310	Shared Neighborhood Hits	152
SwissProt Accessions	P97329, Q542M4	Gene names	Kif20a, Rab6kifl
Domain Architecture
Description	Kinesin family member 20A (Rabkinesin-6) (Rab6-interacting kinesin- like protein) (Kinesin-like protein 174).

RHG25_MOUSE
NC score	0.035319 (rank : 2053)	θ value	8.99809 (rank : 1559)
Query Neighborhood Hits	1580	Target Neighborhood Hits	492	Shared Neighborhood Hits	166
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

OGFR_HUMAN
NC score	0.033981 (rank : 2054)	θ value	0.0330416 (rank : 1083)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1582	Shared Neighborhood Hits	204
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RGS3_MOUSE
NC score	0.033736 (rank : 2055)	θ value	0.0193708 (rank : 1062)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1621	Shared Neighborhood Hits	213
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ANR11_HUMAN
NC score	0.033425 (rank : 2056)	θ value	1.38821 (rank : 1297)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1289	Shared Neighborhood Hits	256
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

TENS4_MOUSE
NC score	0.033216 (rank : 2057)	θ value	4.03905 (rank : 1439)
Query Neighborhood Hits	1580	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

RGS3_HUMAN
NC score	0.033068 (rank : 2058)	θ value	6.88961 (rank : 1509)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1375	Shared Neighborhood Hits	179
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

AINX_HUMAN
NC score	0.032835 (rank : 2059)	θ value	4.03905 (rank : 1415)
Query Neighborhood Hits	1580	Target Neighborhood Hits	442	Shared Neighborhood Hits	208
SwissProt Accessions	Q16352, Q9BRC5	Gene names	INA
Domain Architecture
Description	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (Neurofilament-66) (NF-66).

FYV1_HUMAN
NC score	0.032459 (rank : 2060)	θ value	1.06291 (rank : 1279)
Query Neighborhood Hits	1580	Target Neighborhood Hits	217	Shared Neighborhood Hits	56
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

LAMA1_HUMAN
NC score	0.031303 (rank : 2061)	θ value	0.62314 (rank : 1239)
Query Neighborhood Hits	1580	Target Neighborhood Hits	804	Shared Neighborhood Hits	214
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

COG3_HUMAN
NC score	0.031141 (rank : 2062)	θ value	0.0193708 (rank : 1056)
Query Neighborhood Hits	1580	Target Neighborhood Hits	56	Shared Neighborhood Hits	30
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

TANK_MOUSE
NC score	0.029825 (rank : 2063)	θ value	0.0736092 (rank : 1122)
Query Neighborhood Hits	1580	Target Neighborhood Hits	80	Shared Neighborhood Hits	44
SwissProt Accessions	P70347, Q61178	Gene names	Tank, Itraf
Domain Architecture
Description	TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF).

FA76B_HUMAN
NC score	0.029675 (rank : 2064)	θ value	6.88961 (rank : 1486)
Query Neighborhood Hits	1580	Target Neighborhood Hits	184	Shared Neighborhood Hits	97
SwissProt Accessions	Q5HYJ3, Q6PIU3, Q8TC53	Gene names	FAM76B
Domain Architecture	No domain graphic available
Description	Protein FAM76B.

K2C3_HUMAN
NC score	0.028682 (rank : 2065)	θ value	0.0431538 (rank : 1089)
Query Neighborhood Hits	1580	Target Neighborhood Hits	443	Shared Neighborhood Hits	180
SwissProt Accessions	P12035, Q701L8	Gene names	KRT3
Domain Architecture
Description	Keratin, type II cytoskeletal 3 (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (65 kDa cytokeratin).

GRIN1_HUMAN
NC score	0.028239 (rank : 2066)	θ value	0.47712 (rank : 1226)
Query Neighborhood Hits	1580	Target Neighborhood Hits	681	Shared Neighborhood Hits	105
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

TMCC2_MOUSE
NC score	0.028062 (rank : 2067)	θ value	0.0736092 (rank : 1124)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	117
SwissProt Accessions	Q80W04, Q6A061	Gene names	Tmcc2, Kiaa0481
Domain Architecture	No domain graphic available
Description	Transmembrane and coiled-coil domains protein 2.

FA76B_MOUSE
NC score	0.027986 (rank : 2068)	θ value	3.0926 (rank : 1387)
Query Neighborhood Hits	1580	Target Neighborhood Hits	181	Shared Neighborhood Hits	95
SwissProt Accessions	Q80XP8, Q3UMA6, Q80YR1, Q8CI69	Gene names	Fam76b
Domain Architecture	No domain graphic available
Description	Protein FAM76B.

SON_HUMAN
NC score	0.027898 (rank : 2069)	θ value	5.27518 (rank : 1470)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1568	Shared Neighborhood Hits	208
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

T22D4_HUMAN
NC score	0.027847 (rank : 2070)	θ value	0.00298849 (rank : 994)
Query Neighborhood Hits	1580	Target Neighborhood Hits	403	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

PARVB_MOUSE
NC score	0.027653 (rank : 2071)	θ value	0.365318 (rank : 1210)
Query Neighborhood Hits	1580	Target Neighborhood Hits	43	Shared Neighborhood Hits	26
SwissProt Accessions	Q9ES46	Gene names	Parvb
Domain Architecture
Description	Beta-parvin.

CEP68_HUMAN
NC score	0.027193 (rank : 2072)	θ value	0.0961366 (rank : 1131)
Query Neighborhood Hits	1580	Target Neighborhood Hits	128	Shared Neighborhood Hits	42
SwissProt Accessions	Q76N32, O60326, Q9BQ18, Q9UDM9	Gene names	CEP68, KIAA0582
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

SEPT7_MOUSE
NC score	0.026901 (rank : 2073)	θ value	8.99809 (rank : 1562)
Query Neighborhood Hits	1580	Target Neighborhood Hits	327	Shared Neighborhood Hits	158
SwissProt Accessions	O55131	Gene names	Sept7, Cdc10
Domain Architecture
Description	Septin-7 (CDC10 protein homolog).

TGON2_HUMAN
NC score	0.026185 (rank : 2074)	θ value	1.38821 (rank : 1318)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1037	Shared Neighborhood Hits	147
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

CEP68_MOUSE
NC score	0.026045 (rank : 2075)	θ value	0.279714 (rank : 1185)
Query Neighborhood Hits	1580	Target Neighborhood Hits	62	Shared Neighborhood Hits	25
SwissProt Accessions	Q8C0D9, Q3US49, Q5SW85, Q8R2V0	Gene names	Cep68
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 68 kDa (Cep68 protein).

MAP4_MOUSE
NC score	0.025778 (rank : 2076)	θ value	0.163984 (rank : 1161)
Query Neighborhood Hits	1580	Target Neighborhood Hits	409	Shared Neighborhood Hits	86
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

COG3_MOUSE
NC score	0.025754 (rank : 2077)	θ value	0.47712 (rank : 1223)
Query Neighborhood Hits	1580	Target Neighborhood Hits	59	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CI04	Gene names	Cog3
Domain Architecture	No domain graphic available
Description	Conserved oligomeric Golgi complex component 3.

PARVB_HUMAN
NC score	0.025578 (rank : 2078)	θ value	1.38821 (rank : 1312)
Query Neighborhood Hits	1580	Target Neighborhood Hits	42	Shared Neighborhood Hits	24
SwissProt Accessions	Q9HBI1, Q5TGJ5, Q86X93, Q9NSP7, Q9UGT3, Q9Y368, Q9Y3L6, Q9Y3L7	Gene names	PARVB
Domain Architecture
Description	Beta-parvin (Affixin).

TCOF_HUMAN
NC score	0.025479 (rank : 2079)	θ value	2.36792 (rank : 1370)
Query Neighborhood Hits	1580	Target Neighborhood Hits	543	Shared Neighborhood Hits	111
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

IWS1_HUMAN
NC score	0.025290 (rank : 2080)	θ value	0.0563607 (rank : 1106)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1241	Shared Neighborhood Hits	175
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ANK2_HUMAN
NC score	0.025048 (rank : 2081)	θ value	6.88961 (rank : 1477)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1615	Shared Neighborhood Hits	241
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

SIGIR_MOUSE
NC score	0.023602 (rank : 2082)	θ value	6.88961 (rank : 1513)
Query Neighborhood Hits	1580	Target Neighborhood Hits	95	Shared Neighborhood Hits	50
SwissProt Accessions	Q9JLZ8, Q52L48	Gene names	Sigirr, Tir8
Domain Architecture	No domain graphic available
Description	Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8).

FOXP2_MOUSE
NC score	0.023531 (rank : 2083)	θ value	5.27518 (rank : 1452)
Query Neighborhood Hits	1580	Target Neighborhood Hits	366	Shared Neighborhood Hits	149
SwissProt Accessions	P58463, Q6PD37, Q8C4F0, Q8R441	Gene names	Foxp2
Domain Architecture
Description	Forkhead box protein P2.

MBB1A_HUMAN
NC score	0.023050 (rank : 2084)	θ value	5.27518 (rank : 1462)
Query Neighborhood Hits	1580	Target Neighborhood Hits	665	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

RUSC2_HUMAN
NC score	0.023010 (rank : 2085)	θ value	5.27518 (rank : 1468)
Query Neighborhood Hits	1580	Target Neighborhood Hits	205	Shared Neighborhood Hits	63
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SNPC4_HUMAN
NC score	0.022898 (rank : 2086)	θ value	1.81305 (rank : 1340)
Query Neighborhood Hits	1580	Target Neighborhood Hits	589	Shared Neighborhood Hits	115
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

FOXP2_HUMAN
NC score	0.022700 (rank : 2087)	θ value	3.0926 (rank : 1390)
Query Neighborhood Hits	1580	Target Neighborhood Hits	366	Shared Neighborhood Hits	146
SwissProt Accessions	O15409, Q6ZND1, Q75MJ3, Q8IZE0, Q8N0W2, Q8N6B7, Q8N6B8, Q8NFQ1, Q8NFQ2, Q8NFQ3, Q8NFQ4, Q8TD74	Gene names	FOXP2, CAGH44, TNRC10
Domain Architecture
Description	Forkhead box protein P2 (CAG repeat protein 44) (Trinucleotide repeat- containing gene 10 protein).

FMN2_HUMAN
NC score	0.022253 (rank : 2088)	θ value	5.27518 (rank : 1451)
Query Neighborhood Hits	1580	Target Neighborhood Hits	484	Shared Neighborhood Hits	130
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

REPS1_MOUSE
NC score	0.022196 (rank : 2089)	θ value	3.0926 (rank : 1404)
Query Neighborhood Hits	1580	Target Neighborhood Hits	204	Shared Neighborhood Hits	52
SwissProt Accessions	O54916, Q8C9J9, Q99LR8	Gene names	Reps1
Domain Architecture
Description	RalBP1-associated Eps domain-containing protein 1 (RalBP1-interacting protein 1).

TP53B_MOUSE
NC score	0.021016 (rank : 2090)	θ value	1.38821 (rank : 1319)
Query Neighborhood Hits	1580	Target Neighborhood Hits	644	Shared Neighborhood Hits	105
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

MAGE1_HUMAN
NC score	0.019778 (rank : 2091)	θ value	2.44474e-05 (rank : 823)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1389	Shared Neighborhood Hits	180
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

IWS1_MOUSE
NC score	0.019522 (rank : 2092)	θ value	0.0193708 (rank : 1059)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1258	Shared Neighborhood Hits	160
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

NCOR1_HUMAN
NC score	0.019139 (rank : 2093)	θ value	6.88961 (rank : 1499)
Query Neighborhood Hits	1580	Target Neighborhood Hits	577	Shared Neighborhood Hits	133
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

MTSS1_MOUSE
NC score	0.019127 (rank : 2094)	θ value	3.0926 (rank : 1396)
Query Neighborhood Hits	1580	Target Neighborhood Hits	592	Shared Neighborhood Hits	101
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

BTNL1_MOUSE
NC score	0.018708 (rank : 2095)	θ value	0.813845 (rank : 1251)
Query Neighborhood Hits	1580	Target Neighborhood Hits	151	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TST0, O70356	Gene names	Btnl1, Btnl3, Gm316, Ng10
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 1 precursor.

CABIN_HUMAN
NC score	0.018435 (rank : 2096)	θ value	3.0926 (rank : 1378)
Query Neighborhood Hits	1580	Target Neighborhood Hits	490	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

MUC13_MOUSE
NC score	0.018372 (rank : 2097)	θ value	6.88961 (rank : 1495)
Query Neighborhood Hits	1580	Target Neighborhood Hits	447	Shared Neighborhood Hits	77
SwissProt Accessions	P19467	Gene names	Muc13, Ly64
Domain Architecture
Description	Mucin-13 precursor (Cell surface antigen 114/A10) (Lymphocyte antigen 64).

K0310_HUMAN
NC score	0.017998 (rank : 2098)	θ value	2.36792 (rank : 1359)
Query Neighborhood Hits	1580	Target Neighborhood Hits	420	Shared Neighborhood Hits	70
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

ZAR1_HUMAN
NC score	0.017601 (rank : 2099)	θ value	8.99809 (rank : 1577)
Query Neighborhood Hits	1580	Target Neighborhood Hits	163	Shared Neighborhood Hits	31
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

MUC1_HUMAN
NC score	0.017467 (rank : 2100)	θ value	0.813845 (rank : 1262)
Query Neighborhood Hits	1580	Target Neighborhood Hits	975	Shared Neighborhood Hits	129
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

GRIN1_MOUSE
NC score	0.016947 (rank : 2101)	θ value	8.99809 (rank : 1541)
Query Neighborhood Hits	1580	Target Neighborhood Hits	337	Shared Neighborhood Hits	69
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

SVIL_MOUSE
NC score	0.016662 (rank : 2102)	θ value	2.36792 (rank : 1369)
Query Neighborhood Hits	1580	Target Neighborhood Hits	439	Shared Neighborhood Hits	86
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

UN84A_MOUSE
NC score	0.016627 (rank : 2103)	θ value	5.27518 (rank : 1472)
Query Neighborhood Hits	1580	Target Neighborhood Hits	99	Shared Neighborhood Hits	52
SwissProt Accessions	Q9D666, Q80SU8, Q8BZ99, Q99P23	Gene names	Unc84a, Sun1
Domain Architecture	No domain graphic available
Description	Sad1/unc-84 protein-like 1 (Unc-84 homolog A).

SHLB1_HUMAN
NC score	0.016381 (rank : 2104)	θ value	8.99809 (rank : 1565)
Query Neighborhood Hits	1580	Target Neighborhood Hits	96	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

CIC_HUMAN
NC score	0.015832 (rank : 2105)	θ value	1.06291 (rank : 1274)
Query Neighborhood Hits	1580	Target Neighborhood Hits	992	Shared Neighborhood Hits	135
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

RTN4_HUMAN
NC score	0.015788 (rank : 2106)	θ value	4.03905 (rank : 1436)
Query Neighborhood Hits	1580	Target Neighborhood Hits	357	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SHLB1_MOUSE
NC score	0.014892 (rank : 2107)	θ value	6.88961 (rank : 1512)
Query Neighborhood Hits	1580	Target Neighborhood Hits	101	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

RINT1_MOUSE
NC score	0.014717 (rank : 2108)	θ value	8.99809 (rank : 1560)
Query Neighborhood Hits	1580	Target Neighborhood Hits	98	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BZ36, Q3UXS1, Q6P1I2, Q8C193	Gene names	Rint1
Domain Architecture	No domain graphic available
Description	RAD50-interacting protein 1 (RAD50 interactor 1) (Protein RINT-1).

BCL9_HUMAN
NC score	0.014605 (rank : 2109)	θ value	0.279714 (rank : 1184)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1008	Shared Neighborhood Hits	126
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

REXO1_HUMAN
NC score	0.014321 (rank : 2110)	θ value	0.62314 (rank : 1243)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

PHC1_MOUSE
NC score	0.013922 (rank : 2111)	θ value	3.0926 (rank : 1398)
Query Neighborhood Hits	1580	Target Neighborhood Hits	205	Shared Neighborhood Hits	52
SwissProt Accessions	Q64028, P70359, Q64307, Q8BZ80	Gene names	Phc1, Edr, Edr1, Rae28
Domain Architecture
Description	Polyhomeotic-like protein 1 (mPH1) (Early development regulatory protein 1) (RAE-28).

LEUK_HUMAN
NC score	0.013869 (rank : 2112)	θ value	6.88961 (rank : 1493)
Query Neighborhood Hits	1580	Target Neighborhood Hits	213	Shared Neighborhood Hits	40
SwissProt Accessions	P16150	Gene names	SPN, CD43
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Galactoglycoprotein) (GALGP) (CD43 antigen).

PHC1_HUMAN
NC score	0.013509 (rank : 2113)	θ value	1.81305 (rank : 1335)
Query Neighborhood Hits	1580	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	P78364, Q8WVM3, Q9BU63	Gene names	PHC1, EDR1, PH1
Domain Architecture
Description	Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1).

MYCB2_HUMAN
NC score	0.013358 (rank : 2114)	θ value	6.88961 (rank : 1497)
Query Neighborhood Hits	1580	Target Neighborhood Hits	390	Shared Neighborhood Hits	53
SwissProt Accessions	O75592, Q5JSX8, Q5VZN6, Q6PIB6, Q9UQ11, Q9Y6E4	Gene names	MYCBP2, KIAA0916, PAM
Domain Architecture	No domain graphic available
Description	Probable ubiquitin ligase protein MYCBP2 (EC 6.3.2.-) (Myc-binding protein 2) (Protein associated with Myc) (Pam/highwire/rpm-1 protein).

TPSNR_MOUSE
NC score	0.013056 (rank : 2115)	θ value	8.99809 (rank : 1574)
Query Neighborhood Hits	1580	Target Neighborhood Hits	336	Shared Neighborhood Hits	78
SwissProt Accessions	Q8VD31	Gene names	Tapbpl
Domain Architecture	No domain graphic available
Description	Tapasin-related protein precursor (TAPASIN-R) (Tapasin-like) (TAP- binding protein-related protein) (TAPBP-R) (TAP-binding protein-like).

CBP_MOUSE
NC score	0.012987 (rank : 2116)	θ value	1.38821 (rank : 1300)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1051	Shared Neighborhood Hits	148
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SYCC_HUMAN
NC score	0.012896 (rank : 2117)	θ value	0.365318 (rank : 1218)
Query Neighborhood Hits	1580	Target Neighborhood Hits	51	Shared Neighborhood Hits	22
SwissProt Accessions	P49589, Q53XI8, Q9HD24, Q9HD25	Gene names	CARS
Domain Architecture
Description	Cysteinyl-tRNA synthetase, cytoplasmic (EC 6.1.1.16) (Cysteine--tRNA ligase) (CysRS).

MAML3_HUMAN
NC score	0.012392 (rank : 2118)	θ value	5.27518 (rank : 1461)
Query Neighborhood Hits	1580	Target Neighborhood Hits	323	Shared Neighborhood Hits	66
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

FIP1_HUMAN
NC score	0.012146 (rank : 2119)	θ value	1.81305 (rank : 1326)
Query Neighborhood Hits	1580	Target Neighborhood Hits	118	Shared Neighborhood Hits	27
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

BT1A1_HUMAN
NC score	0.012036 (rank : 2120)	θ value	4.03905 (rank : 1421)
Query Neighborhood Hits	1580	Target Neighborhood Hits	322	Shared Neighborhood Hits	98
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

GPTC8_HUMAN
NC score	0.011536 (rank : 2121)	θ value	8.99809 (rank : 1540)
Query Neighborhood Hits	1580	Target Neighborhood Hits	366	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

BCL9_MOUSE
NC score	0.011534 (rank : 2122)	θ value	1.06291 (rank : 1271)
Query Neighborhood Hits	1580	Target Neighborhood Hits	770	Shared Neighborhood Hits	110
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

PALB2_MOUSE
NC score	0.011487 (rank : 2123)	θ value	1.06291 (rank : 1290)
Query Neighborhood Hits	1580	Target Neighborhood Hits	133	Shared Neighborhood Hits	27
SwissProt Accessions	Q3U0P1, Q6NZG9, Q7TMQ4, Q8CEA9	Gene names	Palb2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

PSL1_HUMAN
NC score	0.011451 (rank : 2124)	θ value	8.99809 (rank : 1558)
Query Neighborhood Hits	1580	Target Neighborhood Hits	650	Shared Neighborhood Hits	73
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

MAVS_MOUSE
NC score	0.011084 (rank : 2125)	θ value	4.03905 (rank : 1434)
Query Neighborhood Hits	1580	Target Neighborhood Hits	170	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VCF0	Gene names	Mavs, Ips1, Visa
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif).

SF3B1_MOUSE
NC score	0.010905 (rank : 2126)	θ value	8.99809 (rank : 1564)
Query Neighborhood Hits	1580	Target Neighborhood Hits	352	Shared Neighborhood Hits	54
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

IF39_MOUSE
NC score	0.010677 (rank : 2127)	θ value	6.88961 (rank : 1490)
Query Neighborhood Hits	1580	Target Neighborhood Hits	206	Shared Neighborhood Hits	37
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

HPLN2_MOUSE
NC score	0.010547 (rank : 2128)	θ value	6.88961 (rank : 1488)
Query Neighborhood Hits	1580	Target Neighborhood Hits	102	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ESM3	Gene names	Hapln2, Bral1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

HELZ_HUMAN
NC score	0.010427 (rank : 2129)	θ value	0.0736092 (rank : 1118)
Query Neighborhood Hits	1580	Target Neighborhood Hits	198	Shared Neighborhood Hits	33
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

SF3B1_HUMAN
NC score	0.010415 (rank : 2130)	θ value	8.99809 (rank : 1563)
Query Neighborhood Hits	1580	Target Neighborhood Hits	341	Shared Neighborhood Hits	52
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

TEX15_HUMAN
NC score	0.010317 (rank : 2131)	θ value	8.99809 (rank : 1571)
Query Neighborhood Hits	1580	Target Neighborhood Hits	174	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BXT5	Gene names	TEX15
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 15 protein.

SAS10_HUMAN
NC score	0.010264 (rank : 2132)	θ value	8.99809 (rank : 1561)
Query Neighborhood Hits	1580	Target Neighborhood Hits	102	Shared Neighborhood Hits	41
SwissProt Accessions	Q9NQZ2, Q6FI82	Gene names	CRLZ1, SAS10
Domain Architecture	No domain graphic available
Description	Something about silencing protein 10 (Disrupter of silencing SAS10) (Charged amino acid-rich leucine zipper 1).

SYCC_MOUSE
NC score	0.010098 (rank : 2133)	θ value	1.81305 (rank : 1342)
Query Neighborhood Hits	1580	Target Neighborhood Hits	63	Shared Neighborhood Hits	17
SwissProt Accessions	Q9ER72, O88303, Q8BP81, Q8CAY7, Q8CCE3, Q8K0S4, Q9ER68	Gene names	Cars
Domain Architecture
Description	Cysteinyl-tRNA synthetase, cytoplasmic (EC 6.1.1.16) (Cysteine--tRNA ligase) (CysRS).

CDT1_MOUSE
NC score	0.009985 (rank : 2134)	θ value	5.27518 (rank : 1447)
Query Neighborhood Hits	1580	Target Neighborhood Hits	72	Shared Neighborhood Hits	23
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

ASXL1_HUMAN
NC score	0.009878 (rank : 2135)	θ value	6.88961 (rank : 1479)
Query Neighborhood Hits	1580	Target Neighborhood Hits	260	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IXJ9, Q5JWS9, Q8IYY7, Q9H466, Q9NQF8, Q9UFJ0, Q9UFP8, Q9Y2I4	Gene names	ASXL1, KIAA0978
Domain Architecture	No domain graphic available
Description	Putative Polycomb group protein ASXL1 (Additional sex combs-like protein 1).

BRD8_MOUSE
NC score	0.009488 (rank : 2136)	θ value	0.62314 (rank : 1234)
Query Neighborhood Hits	1580	Target Neighborhood Hits	422	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

ELOA1_HUMAN
NC score	0.009296 (rank : 2137)	θ value	1.81305 (rank : 1325)
Query Neighborhood Hits	1580	Target Neighborhood Hits	388	Shared Neighborhood Hits	46
SwissProt Accessions	Q14241, Q8IXH1	Gene names	TCEB3
Domain Architecture
Description	Transcription elongation factor B polypeptide 3 (RNA polymerase II transcription factor SIII subunit A1) (SIII p110) (Elongin-A) (EloA) (Elongin 110 kDa subunit).

ZCPW1_MOUSE
NC score	0.009052 (rank : 2138)	θ value	6.88961 (rank : 1521)
Query Neighborhood Hits	1580	Target Neighborhood Hits	307	Shared Neighborhood Hits	57
SwissProt Accessions	Q6IR42	Gene names	Zcwpw1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1 homolog.

PCX3_MOUSE
NC score	0.008948 (rank : 2139)	θ value	6.88961 (rank : 1504)
Query Neighborhood Hits	1580	Target Neighborhood Hits	134	Shared Neighborhood Hits	35
SwissProt Accessions	Q8VI59	Gene names	Pcnxl3
Domain Architecture
Description	Pecanex-like protein 3.

RMP_HUMAN
NC score	0.008940 (rank : 2140)	θ value	5.27518 (rank : 1467)
Query Neighborhood Hits	1580	Target Neighborhood Hits	40	Shared Neighborhood Hits	11
SwissProt Accessions	O94763	Gene names	RMP, C19orf2
Domain Architecture
Description	RNA polymerase II subunit 5-mediating protein (RPB5-mediating protein).

HN1L_HUMAN
NC score	0.008728 (rank : 2141)	θ value	4.03905 (rank : 1431)
Query Neighborhood Hits	1580	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	Q9H910, Q6EIC7	Gene names	C16orf34, HN1L
Domain Architecture	No domain graphic available
Description	Hematological and neurological expressed 1-like protein (HN1-like protein).

IRS1_MOUSE
NC score	0.008437 (rank : 2142)	θ value	8.99809 (rank : 1544)
Query Neighborhood Hits	1580	Target Neighborhood Hits	112	Shared Neighborhood Hits	26
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

SYN3_HUMAN
NC score	0.008387 (rank : 2143)	θ value	3.0926 (rank : 1407)
Query Neighborhood Hits	1580	Target Neighborhood Hits	203	Shared Neighborhood Hits	41
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

P66A_MOUSE
NC score	0.008331 (rank : 2144)	θ value	0.47712 (rank : 1230)
Query Neighborhood Hits	1580	Target Neighborhood Hits	58	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CHY6, Q8BTQ2, Q8VEC9	Gene names	Gatad2a
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 alpha (GATA zinc finger domain- containing protein 2A).

X3CL1_HUMAN
NC score	0.008141 (rank : 2145)	θ value	0.365318 (rank : 1221)
Query Neighborhood Hits	1580	Target Neighborhood Hits	152	Shared Neighborhood Hits	21
SwissProt Accessions	P78423, O00672	Gene names	CX3CL1, A-152E5.2, FKN, NTT, SCYD1
Domain Architecture
Description	Fractalkine precursor (CX3CL1) (Neurotactin) (CX3C membrane-anchored chemokine) (Small inducible cytokine D1).

HPLN2_HUMAN
NC score	0.007964 (rank : 2146)	θ value	1.38821 (rank : 1304)
Query Neighborhood Hits	1580	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q9GZV7	Gene names	HAPLN2, BRAL1
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 2 precursor (Brain link protein 1).

FIP1_MOUSE
NC score	0.007947 (rank : 2147)	θ value	6.88961 (rank : 1487)
Query Neighborhood Hits	1580	Target Neighborhood Hits	120	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D824, Q8BWX7, Q99LH0, Q9DBB2	Gene names	Fip1l1
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1).

PRGC2_HUMAN
NC score	0.007816 (rank : 2148)	θ value	5.27518 (rank : 1465)
Query Neighborhood Hits	1580	Target Neighborhood Hits	272	Shared Neighborhood Hits	38
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

NCOA1_MOUSE
NC score	0.007779 (rank : 2149)	θ value	0.0961366 (rank : 1136)
Query Neighborhood Hits	1580	Target Neighborhood Hits	196	Shared Neighborhood Hits	37
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

TRI63_HUMAN
NC score	0.007562 (rank : 2150)	θ value	3.0926 (rank : 1413)
Query Neighborhood Hits	1580	Target Neighborhood Hits	298	Shared Neighborhood Hits	86
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

CO033_MOUSE
NC score	0.007147 (rank : 2151)	θ value	2.36792 (rank : 1350)
Query Neighborhood Hits	1580	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D518	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf33 homolog.

HPLN4_HUMAN
NC score	0.006609 (rank : 2152)	θ value	6.88961 (rank : 1489)
Query Neighborhood Hits	1580	Target Neighborhood Hits	100	Shared Neighborhood Hits	49
SwissProt Accessions	Q86UW8, Q96PW2	Gene names	HAPLN4, BRAL2, KIAA1926
Domain Architecture
Description	Hyaluronan and proteoglycan link protein 4 precursor (Brain link protein 2).

DSCR6_HUMAN
NC score	0.006601 (rank : 2153)	θ value	8.99809 (rank : 1534)
Query Neighborhood Hits	1580	Target Neighborhood Hits	22	Shared Neighborhood Hits	4
SwissProt Accessions	P57055	Gene names	DSCR6, RIPPLY3
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 6.

CBX2_HUMAN
NC score	0.006334 (rank : 2154)	θ value	2.36792 (rank : 1348)
Query Neighborhood Hits	1580	Target Neighborhood Hits	264	Shared Neighborhood Hits	38
SwissProt Accessions	Q14781, Q9BTB1	Gene names	CBX2
Domain Architecture	No domain graphic available
Description	Chromobox protein homolog 2.

TF3B_MOUSE
NC score	0.006310 (rank : 2155)	θ value	2.36792 (rank : 1371)
Query Neighborhood Hits	1580	Target Neighborhood Hits	69	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CFK2	Gene names	Brf1
Domain Architecture	No domain graphic available
Description	Transcription factor IIIB 90 kDa subunit (TFIIIB90) (hTFIIIB90) (B- related factor 1) (BRF-1).

FBX34_MOUSE
NC score	0.006209 (rank : 2156)	θ value	3.0926 (rank : 1388)
Query Neighborhood Hits	1580	Target Neighborhood Hits	100	Shared Neighborhood Hits	19
SwissProt Accessions	Q80XI1, Q9D290	Gene names	Fbxo34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

NCOA1_HUMAN
NC score	0.005326 (rank : 2157)	θ value	1.06291 (rank : 1286)
Query Neighborhood Hits	1580	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

GORS2_MOUSE
NC score	0.005210 (rank : 2158)	θ value	5.27518 (rank : 1453)
Query Neighborhood Hits	1580	Target Neighborhood Hits	89	Shared Neighborhood Hits	19
SwissProt Accessions	Q99JX3, Q3U9D2, Q8CCD0, Q91W68	Gene names	Gorasp2
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55).

IRS1_HUMAN
NC score	0.005152 (rank : 2159)	θ value	5.27518 (rank : 1454)
Query Neighborhood Hits	1580	Target Neighborhood Hits	109	Shared Neighborhood Hits	21
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

JAD1D_MOUSE
NC score	0.005053 (rank : 2160)	θ value	2.36792 (rank : 1357)
Query Neighborhood Hits	1580	Target Neighborhood Hits	228	Shared Neighborhood Hits	65
SwissProt Accessions	Q62240, Q9QVR9, Q9R040	Gene names	Smcy, Hya, Jarid1d
Domain Architecture
Description	Jumonji/ARID domain-containing protein 1D (SmcY protein) (Histocompatibility Y antigen) (H-Y).

CCD71_HUMAN
NC score	0.004682 (rank : 2161)	θ value	8.99809 (rank : 1527)
Query Neighborhood Hits	1580	Target Neighborhood Hits	55	Shared Neighborhood Hits	16
SwissProt Accessions	Q8IV32, Q6IPE2, Q9H8H4, Q9H9F1	Gene names	CCDC71
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 71.

COQ6_MOUSE
NC score	0.004084 (rank : 2162)	θ value	3.0926 (rank : 1380)
Query Neighborhood Hits	1580	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R1S0	Gene names	Coq6
Domain Architecture
Description	Ubiquinone biosynthesis monooxygenase COQ6 (EC 1.14.13.-).

T240L_HUMAN
NC score	0.003562 (rank : 2163)	θ value	4.03905 (rank : 1438)
Query Neighborhood Hits	1580	Target Neighborhood Hits	132	Shared Neighborhood Hits	22
SwissProt Accessions	Q71F56, Q68DN4, Q9H8C0, Q9NSY9, Q9UFD8, Q9UPX5	Gene names	THRAP2, KIAA1025, PROSIT240, TRAP240L
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor-associated protein 2 (Thyroid hormone receptor-associated protein complex 240 kDa component-like).

URFB1_HUMAN
NC score	0.003371 (rank : 2164)	θ value	5.27518 (rank : 1473)
Query Neighborhood Hits	1580	Target Neighborhood Hits	67	Shared Neighborhood Hits	7
SwissProt Accessions	Q6BDS2, Q9NXE0	Gene names	UHRF1BP1, C6orf107
Domain Architecture	No domain graphic available
Description	UHRF1-binding protein 1 (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1) (ICBP90-binding protein 1).

MUCDL_MOUSE
NC score	0.002971 (rank : 2165)	θ value	6.88961 (rank : 1496)
Query Neighborhood Hits	1580	Target Neighborhood Hits	461	Shared Neighborhood Hits	67
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

ITPR1_HUMAN
NC score	0.002920 (rank : 2166)	θ value	2.36792 (rank : 1356)
Query Neighborhood Hits	1580	Target Neighborhood Hits	90	Shared Neighborhood Hits	32
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

THUM1_MOUSE
NC score	0.002278 (rank : 2167)	θ value	8.99809 (rank : 1572)
Query Neighborhood Hits	1580	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q99J36, Q3U6Y3	Gene names	Thumpd1
Domain Architecture
Description	THUMP domain-containing protein 1.

SYRM_MOUSE
NC score	0.002223 (rank : 2168)	θ value	4.03905 (rank : 1437)
Query Neighborhood Hits	1580	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q3U186, Q8QZU7	Gene names	Rarsl, Rars2
Domain Architecture	No domain graphic available
Description	Probable arginyl-tRNA synthetase, mitochondrial precursor (EC 6.1.1.19) (Arginine--tRNA ligase) (ArgRS) (Arginyl-tRNA synthetase-like).

TRI30_MOUSE
NC score	0.001852 (rank : 2169)	θ value	3.0926 (rank : 1412)
Query Neighborhood Hits	1580	Target Neighborhood Hits	434	Shared Neighborhood Hits	118
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

ANS4B_HUMAN
NC score	0.001813 (rank : 2170)	θ value	6.88961 (rank : 1478)
Query Neighborhood Hits	1580	Target Neighborhood Hits	289	Shared Neighborhood Hits	29
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

RFIP5_MOUSE
NC score	0.001686 (rank : 2171)	θ value	6.88961 (rank : 1508)
Query Neighborhood Hits	1580	Target Neighborhood Hits	126	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R361	Gene names	Rab11fip5, D6Ertd32e, Rip11
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 5 (Rab11-FIP5) (Rab11-interacting protein Rip11).

SSBP4_HUMAN
NC score	0.001684 (rank : 2172)	θ value	1.81305 (rank : 1341)
Query Neighborhood Hits	1580	Target Neighborhood Hits	753	Shared Neighborhood Hits	73
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

EZH1_HUMAN
NC score	0.001533 (rank : 2173)	θ value	1.38821 (rank : 1303)
Query Neighborhood Hits	1580	Target Neighborhood Hits	121	Shared Neighborhood Hits	14
SwissProt Accessions	Q92800, O43287, Q14459	Gene names	EZH1, KIAA0388
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

ZFAN3_MOUSE
NC score	0.001457 (rank : 2174)	θ value	8.99809 (rank : 1578)
Query Neighborhood Hits	1580	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q497H0, Q8K230, Q8R2V7, Q8R3V1	Gene names	Zfand3, Tex27
Domain Architecture	No domain graphic available
Description	AN1-type zinc finger protein 3 (Testis-expressed sequence 27).

EZH1_MOUSE
NC score	0.001082 (rank : 2175)	θ value	2.36792 (rank : 1353)
Query Neighborhood Hits	1580	Target Neighborhood Hits	126	Shared Neighborhood Hits	14
SwissProt Accessions	P70351, Q9R089	Gene names	Ezh1, Enx2
Domain Architecture
Description	Enhancer of zeste homolog 1 (ENX-2).

JHD2B_MOUSE
NC score	0.000991 (rank : 2176)	θ value	1.81305 (rank : 1330)
Query Neighborhood Hits	1580	Target Neighborhood Hits	115	Shared Neighborhood Hits	20
SwissProt Accessions	Q6ZPY7, Q2VPQ5, Q5U5V7, Q6P9K3, Q8CCE2, Q8K2A5, Q9CU57	Gene names	Jmjd1b, Jhdm2b, Kiaa1082
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2B (EC 1.14.11.-) (Jumonji domain-containing protein 1B).

KCNH6_HUMAN
NC score	0.000770 (rank : 2177)	θ value	8.99809 (rank : 1545)
Query Neighborhood Hits	1580	Target Neighborhood Hits	222	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H252, Q9BRD7	Gene names	KCNH6, ERG2, HERG2
Domain Architecture
Description	Potassium voltage-gated channel subfamily H member 6 (Voltage-gated potassium channel subunit Kv11.2) (Ether-a-go-go-related gene potassium channel 2) (Ether-a-go-go-related protein 2) (Eag-related protein 2).

JARD2_MOUSE
NC score	0.000768 (rank : 2178)	θ value	5.27518 (rank : 1456)
Query Neighborhood Hits	1580	Target Neighborhood Hits	169	Shared Neighborhood Hits	27
SwissProt Accessions	Q62315, Q99LD1	Gene names	Jarid2, Jmj
Domain Architecture
Description	Jumonji protein (Jumonji/ARID domain-containing protein 2).

BT2A3_HUMAN
NC score	0.000387 (rank : 2179)	θ value	2.36792 (rank : 1347)
Query Neighborhood Hits	1580	Target Neighborhood Hits	195	Shared Neighborhood Hits	45
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

TRAF2_HUMAN
NC score	0.000033 (rank : 2180)	θ value	3.0926 (rank : 1411)
Query Neighborhood Hits	1580	Target Neighborhood Hits	402	Shared Neighborhood Hits	54
SwissProt Accessions	Q12933, Q96NT2	Gene names	TRAF2, TRAP3
Domain Architecture
Description	TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3).

ARNT_MOUSE
NC score	-0.000283 (rank : 2181)	θ value	4.03905 (rank : 1418)
Query Neighborhood Hits	1580	Target Neighborhood Hits	213	Shared Neighborhood Hits	26
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NKTR_MOUSE
NC score	-0.000619 (rank : 2182)	θ value	4.03905 (rank : 1435)
Query Neighborhood Hits	1580	Target Neighborhood Hits	417	Shared Neighborhood Hits	54
SwissProt Accessions	P30415	Gene names	Nktr
Domain Architecture
Description	NK-tumor recognition protein (Natural-killer cells cyclophilin-related protein) (NK-TR protein).

CAC1H_MOUSE
NC score	-0.002270 (rank : 2183)	θ value	5.27518 (rank : 1446)
Query Neighborhood Hits	1580	Target Neighborhood Hits	230	Shared Neighborhood Hits	32
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

IQEC1_HUMAN
NC score	-0.002301 (rank : 2184)	θ value	8.99809 (rank : 1543)
Query Neighborhood Hits	1580	Target Neighborhood Hits	76	Shared Neighborhood Hits	18
SwissProt Accessions	Q6DN90, O94863, Q96D85	Gene names	IQSEC1, ARFGEP100, BRAG2, KIAA0763
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 1 (ADP-ribosylation factors guanine nucleotide-exchange protein 100) (ADP-ribosylation factors guanine nucleotide-exchange protein 2) (Brefeldin-resistant Arf-GEF 2 protein).

CPT1A_MOUSE
NC score	-0.002590 (rank : 2185)	θ value	6.88961 (rank : 1483)
Query Neighborhood Hits	1580	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P97742, O35288, Q80SW3, Q8BP98, Q8C7H8	Gene names	Cpt1a, Cpt-1, Cpt1
Domain Architecture
Description	Carnitine O-palmitoyltransferase I, liver isoform (EC 2.3.1.21) (CPT I) (CPTI-L) (Carnitine palmitoyltransferase 1A).

DHX8_HUMAN
NC score	-0.002795 (rank : 2186)	θ value	5.27518 (rank : 1449)
Query Neighborhood Hits	1580	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	Q14562	Gene names	DHX8, DDX8
Domain Architecture
Description	ATP-dependent RNA helicase DHX8 (EC 3.6.1.-) (DEAH box protein 8) (RNA helicase HRH1).

PKD2_MOUSE
NC score	-0.002898 (rank : 2187)	θ value	8.99809 (rank : 1556)
Query Neighborhood Hits	1580	Target Neighborhood Hits	99	Shared Neighborhood Hits	11
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

TRI43_HUMAN
NC score	-0.003480 (rank : 2188)	θ value	1.81305 (rank : 1345)
Query Neighborhood Hits	1580	Target Neighborhood Hits	341	Shared Neighborhood Hits	77
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

PHF12_MOUSE
NC score	-0.004316 (rank : 2189)	θ value	8.99809 (rank : 1553)
Query Neighborhood Hits	1580	Target Neighborhood Hits	172	Shared Neighborhood Hits	16
SwissProt Accessions	Q5SPL2, Q5SPL3, Q6ZPN8, Q80W50	Gene names	Phf12, Kiaa1523
Domain Architecture	No domain graphic available
Description	PHD finger protein 12 (PHD factor 1) (Pf1).

UBE3A_MOUSE
NC score	-0.004791 (rank : 2190)	θ value	8.99809 (rank : 1575)
Query Neighborhood Hits	1580	Target Neighborhood Hits	47	Shared Neighborhood Hits	7
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

KCNQ2_MOUSE
NC score	-0.004875 (rank : 2191)	θ value	6.88961 (rank : 1492)
Query Neighborhood Hits	1580	Target Neighborhood Hits	163	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

SC6A5_MOUSE
NC score	-0.005319 (rank : 2192)	θ value	5.27518 (rank : 1469)
Query Neighborhood Hits	1580	Target Neighborhood Hits	135	Shared Neighborhood Hits	21
SwissProt Accessions	Q761V0, Q8CFM5, Q91ZQ2	Gene names	Slc6a5, Glyt2
Domain Architecture	No domain graphic available
Description	Sodium- and chloride-dependent glycine transporter 2 (GlyT2) (GlyT-2) (Solute carrier family 6 member 5).

PRGR_MOUSE
NC score	-0.005674 (rank : 2193)	θ value	1.38821 (rank : 1314)
Query Neighborhood Hits	1580	Target Neighborhood Hits	286	Shared Neighborhood Hits	31
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

DDX24_MOUSE
NC score	-0.006150 (rank : 2194)	θ value	6.88961 (rank : 1484)
Query Neighborhood Hits	1580	Target Neighborhood Hits	147	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ESV0, Q61119	Gene names	Ddx24
Domain Architecture
Description	ATP-dependent RNA helicase DDX24 (EC 3.6.1.-) (DEAD box protein 24).

NOTC2_MOUSE
NC score	-0.006480 (rank : 2195)	θ value	0.62314 (rank : 1242)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1069	Shared Neighborhood Hits	72
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

CO4A2_MOUSE
NC score	-0.006574 (rank : 2196)	θ value	1.81305 (rank : 1323)
Query Neighborhood Hits	1580	Target Neighborhood Hits	492	Shared Neighborhood Hits	61
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

CMC2_MOUSE
NC score	-0.006836 (rank : 2197)	θ value	8.99809 (rank : 1532)
Query Neighborhood Hits	1580	Target Neighborhood Hits	98	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXX4, Q9CZF6, Q9DCF5	Gene names	Slc25a13, Aralar2
Domain Architecture
Description	Calcium-binding mitochondrial carrier protein Aralar2 (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13) (Citrin).

TLE3_MOUSE
NC score	-0.007442 (rank : 2198)	θ value	0.813845 (rank : 1268)
Query Neighborhood Hits	1580	Target Neighborhood Hits	378	Shared Neighborhood Hits	36
SwissProt Accessions	Q08122, Q923A4	Gene names	Tle3, Esg
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG) (Grg-3).

CO9A1_MOUSE
NC score	-0.008293 (rank : 2199)	θ value	5.27518 (rank : 1448)
Query Neighborhood Hits	1580	Target Neighborhood Hits	477	Shared Neighborhood Hits	43
SwissProt Accessions	Q05722, Q61269, Q61270, Q61433, Q61940	Gene names	Col9a1
Domain Architecture
Description	Collagen alpha-1(IX) chain precursor.

TLE3_HUMAN
NC score	-0.008411 (rank : 2200)	θ value	3.0926 (rank : 1410)
Query Neighborhood Hits	1580	Target Neighborhood Hits	385	Shared Neighborhood Hits	36
SwissProt Accessions	Q04726, Q8IVV6, Q8WVR2, Q9HCM5	Gene names	TLE3, KIAA1547
Domain Architecture
Description	Transducin-like enhancer protein 3 (ESG3).

PC11X_HUMAN
NC score	-0.012087 (rank : 2201)	θ value	1.81305 (rank : 1334)
Query Neighborhood Hits	1580	Target Neighborhood Hits	199	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BZA7, Q2TJH0, Q2TJH1, Q2TJH3, Q5JVZ0, Q70LR8, Q70LS7, Q70LS8, Q70LS9, Q70LT7, Q70LT8, Q70LT9, Q70LU0, Q70LU1, Q96RV4, Q96RW0, Q9BZA6, Q9H4E0, Q9P2M0, Q9P2X5	Gene names	PCDH11X, PCDH11, PCDHX
Domain Architecture	No domain graphic available
Description	Protocadherin-11 X-linked precursor (Protocadherin-11) (Protocadherin on the X chromosome) (PCDH-X) (Protocadherin-S).

LV1E_HUMAN
NC score	-0.013612 (rank : 2202)	θ value	6.88961 (rank : 1494)
Query Neighborhood Hits	1580	Target Neighborhood Hits	238	Shared Neighborhood Hits	11
SwissProt Accessions	P01703	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda chain V-I region NEWM.

ATBF1_MOUSE
NC score	-0.013911 (rank : 2203)	θ value	0.21417 (rank : 1168)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1841	Shared Neighborhood Hits	176
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

LV1C_MOUSE
NC score	-0.014031 (rank : 2204)	θ value	3.0926 (rank : 1395)
Query Neighborhood Hits	1580	Target Neighborhood Hits	242	Shared Neighborhood Hits	6
SwissProt Accessions	P01725	Gene names
Domain Architecture	No domain graphic available
Description	Ig lambda-1 chain V region S178.

LV2A_MOUSE
NC score	-0.014115 (rank : 2205)	θ value	8.99809 (rank : 1546)
Query Neighborhood Hits	1580	Target Neighborhood Hits	217	Shared Neighborhood Hits	4
SwissProt Accessions	P01728	Gene names
Domain Architecture
Description	Ig lambda-2 chain V region precursor.

HXD3_MOUSE
NC score	-0.017185 (rank : 2206)	θ value	8.99809 (rank : 1542)
Query Neighborhood Hits	1580	Target Neighborhood Hits	435	Shared Neighborhood Hits	26
SwissProt Accessions	P09027, Q3UUD3	Gene names	Hoxd3, Hox-4.1, Hoxd-3
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4.1) (Homeobox protein MH-19).

VAX1_HUMAN
NC score	-0.018137 (rank : 2207)	θ value	8.99809 (rank : 1576)
Query Neighborhood Hits	1580	Target Neighborhood Hits	355	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SQQ9, Q6ZSX0	Gene names	VAX1
Domain Architecture	No domain graphic available
Description	Ventral anterior homeobox 1.

PHX2A_HUMAN
NC score	-0.018227 (rank : 2208)	θ value	8.99809 (rank : 1555)
Query Neighborhood Hits	1580	Target Neighborhood Hits	345	Shared Neighborhood Hits	9
SwissProt Accessions	O14813, Q8IVZ2	Gene names	PHOX2A, ARIX, PMX2A
Domain Architecture
Description	Paired mesoderm homeobox protein 2A (Paired-like homeobox 2A) (Aristaless homeobox protein homolog) (ARIX1 homeodomain protein).

ZN438_HUMAN
NC score	-0.025867 (rank : 2209)	θ value	2.36792 (rank : 1375)
Query Neighborhood Hits	1580	Target Neighborhood Hits	906	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z4V0, Q5T426, Q658Q4, Q6ZN65	Gene names	ZNF438
Domain Architecture	No domain graphic available
Description	Zinc finger protein 438.

SALL2_HUMAN
NC score	-0.027111 (rank : 2210)	θ value	3.0926 (rank : 1406)
Query Neighborhood Hits	1580	Target Neighborhood Hits	835	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y467, Q9Y4G1	Gene names	SALL2, KIAA0360, SAL2
Domain Architecture	No domain graphic available
Description	Sal-like protein 2 (Zinc finger protein SALL2) (HSal2).

ZN335_HUMAN
NC score	-0.027250 (rank : 2211)	θ value	4.03905 (rank : 1441)
Query Neighborhood Hits	1580	Target Neighborhood Hits	973	Shared Neighborhood Hits	59
SwissProt Accessions	Q9H4Z2, Q9H684	Gene names	ZNF335
Domain Architecture	No domain graphic available
Description	Zinc finger protein 335.

ZN142_HUMAN
NC score	-0.027503 (rank : 2212)	θ value	8.99809 (rank : 1579)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1007	Shared Neighborhood Hits	58
SwissProt Accessions	P52746, Q92510	Gene names	ZNF142, KIAA0236
Domain Architecture	No domain graphic available
Description	Zinc finger protein 142 (HA4654).

ZN692_HUMAN
NC score	-0.028192 (rank : 2213)	θ value	1.38821 (rank : 1320)
Query Neighborhood Hits	1580	Target Neighborhood Hits	808	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BU19, Q5SRA5, Q5SRA6, Q9HBC9, Q9NW93, Q9NWY6, Q9UF97	Gene names	ZNF692
Domain Architecture	No domain graphic available
Description	Zinc finger protein 692.

EGR4_MOUSE
NC score	-0.028478 (rank : 2214)	θ value	0.47712 (rank : 1224)
Query Neighborhood Hits	1580	Target Neighborhood Hits	710	Shared Neighborhood Hits	16
SwissProt Accessions	Q9WUF2	Gene names	Egr4
Domain Architecture
Description	Early growth response protein 4 (EGR-4).

ZN667_HUMAN
NC score	-0.028574 (rank : 2215)	θ value	5.27518 (rank : 1474)
Query Neighborhood Hits	1580	Target Neighborhood Hits	773	Shared Neighborhood Hits	21
SwissProt Accessions	Q5HYK9, Q6B093, Q9H807	Gene names	ZNF667
Domain Architecture	No domain graphic available
Description	Zinc finger protein 667.

ZBTB3_HUMAN
NC score	-0.028759 (rank : 2216)	θ value	6.88961 (rank : 1520)
Query Neighborhood Hits	1580	Target Neighborhood Hits	910	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H5J0	Gene names	ZBTB3
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 3.

ZN679_HUMAN
NC score	-0.028913 (rank : 2217)	θ value	6.88961 (rank : 1522)
Query Neighborhood Hits	1580	Target Neighborhood Hits	746	Shared Neighborhood Hits	21
SwissProt Accessions	Q8IYX0	Gene names	ZNF679
Domain Architecture	No domain graphic available
Description	Zinc finger protein 679.

ZNF81_HUMAN
NC score	-0.029086 (rank : 2218)	θ value	8.99809 (rank : 1580)
Query Neighborhood Hits	1580	Target Neighborhood Hits	786	Shared Neighborhood Hits	21
SwissProt Accessions	P51508, Q6RX22, Q96QH6	Gene names	ZNF81
Domain Architecture	No domain graphic available
Description	Zinc finger protein 81 (HFZ20).

ZBT16_HUMAN
NC score	-0.030559 (rank : 2219)	θ value	3.0926 (rank : 1414)
Query Neighborhood Hits	1580	Target Neighborhood Hits	1010	Shared Neighborhood Hits	37
SwissProt Accessions	Q05516, Q8TAL4	Gene names	ZBTB16, PLZF, ZNF145
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 16 (Zinc finger protein PLZF) (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145).