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Network neighborhood for query Sequence : FGD3_HUMAN

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FGD3_HUMAN
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FGD3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	249	Target Neighborhood Hits	249	Shared Neighborhood Hits	249
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	0 (rank : 2)	NC score	0.978640 (rank : 2)
Query Neighborhood Hits	249	Target Neighborhood Hits	257	Shared Neighborhood Hits	148
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD1_HUMAN
θ value	5.01279e-176 (rank : 3)	NC score	0.947911 (rank : 7)
Query Neighborhood Hits	249	Target Neighborhood Hits	367	Shared Neighborhood Hits	130
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	1.78289e-173 (rank : 4)	NC score	0.946063 (rank : 8)
Query Neighborhood Hits	249	Target Neighborhood Hits	387	Shared Neighborhood Hits	130
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD4_MOUSE
θ value	5.05951e-144 (rank : 5)	NC score	0.956267 (rank : 5)
Query Neighborhood Hits	249	Target Neighborhood Hits	227	Shared Neighborhood Hits	117
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD4_HUMAN
θ value	2.511e-143 (rank : 6)	NC score	0.957184 (rank : 4)
Query Neighborhood Hits	249	Target Neighborhood Hits	219	Shared Neighborhood Hits	117
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD2_HUMAN
θ value	2.06368e-129 (rank : 7)	NC score	0.958998 (rank : 3)
Query Neighborhood Hits	249	Target Neighborhood Hits	151	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	7.33985e-127 (rank : 8)	NC score	0.954095 (rank : 6)
Query Neighborhood Hits	249	Target Neighborhood Hits	163	Shared Neighborhood Hits	112
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD6_MOUSE
θ value	2.57589e-55 (rank : 9)	NC score	0.868323 (rank : 10)
Query Neighborhood Hits	249	Target Neighborhood Hits	282	Shared Neighborhood Hits	108
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
θ value	1.08223e-53 (rank : 10)	NC score	0.868451 (rank : 9)
Query Neighborhood Hits	249	Target Neighborhood Hits	237	Shared Neighborhood Hits	107
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD5_HUMAN
θ value	1.05066e-40 (rank : 11)	NC score	0.799008 (rank : 11)
Query Neighborhood Hits	249	Target Neighborhood Hits	235	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	8.32485e-38 (rank : 12)	NC score	0.792274 (rank : 12)
Query Neighborhood Hits	249	Target Neighborhood Hits	170	Shared Neighborhood Hits	96
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

FARP2_MOUSE
θ value	1.6813e-30 (rank : 13)	NC score	0.566456 (rank : 35)
Query Neighborhood Hits	249	Target Neighborhood Hits	209	Shared Neighborhood Hits	76
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP2_HUMAN
θ value	1.47289e-26 (rank : 14)	NC score	0.545492 (rank : 42)
Query Neighborhood Hits	249	Target Neighborhood Hits	240	Shared Neighborhood Hits	74
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FARP1_HUMAN
θ value	3.28125e-26 (rank : 15)	NC score	0.515031 (rank : 50)
Query Neighborhood Hits	249	Target Neighborhood Hits	241	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

PREX1_HUMAN
θ value	1.05554e-24 (rank : 16)	NC score	0.736814 (rank : 13)
Query Neighborhood Hits	249	Target Neighborhood Hits	177	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ARHG4_HUMAN
θ value	1.2077e-20 (rank : 17)	NC score	0.650990 (rank : 18)
Query Neighborhood Hits	249	Target Neighborhood Hits	242	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ECT2_MOUSE
θ value	8.65492e-19 (rank : 18)	NC score	0.730840 (rank : 14)
Query Neighborhood Hits	249	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
θ value	1.92812e-18 (rank : 19)	NC score	0.717268 (rank : 15)
Query Neighborhood Hits	249	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

DUET_HUMAN
θ value	2.5182e-18 (rank : 20)	NC score	0.228737 (rank : 103)
Query Neighborhood Hits	249	Target Neighborhood Hits	1220	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

ARHG4_MOUSE
θ value	1.80466e-16 (rank : 21)	NC score	0.664942 (rank : 17)
Query Neighborhood Hits	249	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

TRIO_HUMAN
θ value	6.85773e-16 (rank : 22)	NC score	0.219799 (rank : 104)
Query Neighborhood Hits	249	Target Neighborhood Hits	1580	Shared Neighborhood Hits	92
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

NGEF_MOUSE
θ value	1.52774e-15 (rank : 23)	NC score	0.625222 (rank : 23)
Query Neighborhood Hits	249	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_HUMAN
θ value	1.99529e-15 (rank : 24)	NC score	0.638414 (rank : 20)
Query Neighborhood Hits	249	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ITSN1_MOUSE
θ value	3.40345e-15 (rank : 25)	NC score	0.393891 (rank : 78)
Query Neighborhood Hits	249	Target Neighborhood Hits	1669	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PKHG1_HUMAN
θ value	3.40345e-15 (rank : 26)	NC score	0.692447 (rank : 16)
Query Neighborhood Hits	249	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ITSN1_HUMAN
θ value	7.58209e-15 (rank : 27)	NC score	0.394794 (rank : 77)
Query Neighborhood Hits	249	Target Neighborhood Hits	1757	Shared Neighborhood Hits	105
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN2_HUMAN
θ value	4.91457e-14 (rank : 28)	NC score	0.423086 (rank : 72)
Query Neighborhood Hits	249	Target Neighborhood Hits	1173	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

VAV2_MOUSE
θ value	4.91457e-14 (rank : 29)	NC score	0.470883 (rank : 57)
Query Neighborhood Hits	249	Target Neighborhood Hits	456	Shared Neighborhood Hits	78
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

HAPIP_HUMAN
θ value	6.41864e-14 (rank : 30)	NC score	0.537752 (rank : 46)
Query Neighborhood Hits	249	Target Neighborhood Hits	350	Shared Neighborhood Hits	78
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

VAV2_HUMAN
θ value	1.42992e-13 (rank : 31)	NC score	0.461909 (rank : 60)
Query Neighborhood Hits	249	Target Neighborhood Hits	453	Shared Neighborhood Hits	74
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ITSN2_MOUSE
θ value	3.18553e-13 (rank : 32)	NC score	0.400894 (rank : 76)
Query Neighborhood Hits	249	Target Neighborhood Hits	1371	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG2_HUMAN
θ value	9.26847e-13 (rank : 33)	NC score	0.530790 (rank : 48)
Query Neighborhood Hits	249	Target Neighborhood Hits	142	Shared Neighborhood Hits	63
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG5_HUMAN
θ value	9.26847e-13 (rank : 34)	NC score	0.643901 (rank : 19)
Query Neighborhood Hits	249	Target Neighborhood Hits	172	Shared Neighborhood Hits	69
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

VAV3_HUMAN
θ value	2.0648e-12 (rank : 35)	NC score	0.455978 (rank : 62)
Query Neighborhood Hits	249	Target Neighborhood Hits	398	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ARHG2_MOUSE
θ value	2.69671e-12 (rank : 36)	NC score	0.578195 (rank : 30)
Query Neighborhood Hits	249	Target Neighborhood Hits	120	Shared Neighborhood Hits	63
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

VAV3_MOUSE
θ value	2.69671e-12 (rank : 37)	NC score	0.458394 (rank : 61)
Query Neighborhood Hits	249	Target Neighborhood Hits	404	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

MCF2L_MOUSE
θ value	4.59992e-12 (rank : 38)	NC score	0.578579 (rank : 29)
Query Neighborhood Hits	249	Target Neighborhood Hits	255	Shared Neighborhood Hits	70
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHGA_MOUSE
θ value	1.74796e-11 (rank : 39)	NC score	0.601130 (rank : 27)
Query Neighborhood Hits	249	Target Neighborhood Hits	125	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

GNRP_HUMAN
θ value	2.28291e-11 (rank : 40)	NC score	0.480701 (rank : 54)
Query Neighborhood Hits	249	Target Neighborhood Hits	239	Shared Neighborhood Hits	60
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHGA_HUMAN
θ value	2.98157e-11 (rank : 41)	NC score	0.604352 (rank : 26)
Query Neighborhood Hits	249	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

GNRP_MOUSE
θ value	2.98157e-11 (rank : 42)	NC score	0.511716 (rank : 51)
Query Neighborhood Hits	249	Target Neighborhood Hits	191	Shared Neighborhood Hits	61
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGB_HUMAN
θ value	3.89403e-11 (rank : 43)	NC score	0.537140 (rank : 47)
Query Neighborhood Hits	249	Target Neighborhood Hits	375	Shared Neighborhood Hits	72
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

VAV_MOUSE
θ value	6.64225e-11 (rank : 44)	NC score	0.472018 (rank : 56)
Query Neighborhood Hits	249	Target Neighborhood Hits	430	Shared Neighborhood Hits	69
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ARHGC_MOUSE
θ value	8.67504e-11 (rank : 45)	NC score	0.510523 (rank : 53)
Query Neighborhood Hits	249	Target Neighborhood Hits	344	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

VAV_HUMAN
θ value	1.133e-10 (rank : 46)	NC score	0.463633 (rank : 59)
Query Neighborhood Hits	249	Target Neighborhood Hits	452	Shared Neighborhood Hits	70
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG1_HUMAN
θ value	1.47974e-10 (rank : 47)	NC score	0.567839 (rank : 33)
Query Neighborhood Hits	249	Target Neighborhood Hits	176	Shared Neighborhood Hits	82
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG9_HUMAN
θ value	1.47974e-10 (rank : 48)	NC score	0.628600 (rank : 21)
Query Neighborhood Hits	249	Target Neighborhood Hits	235	Shared Neighborhood Hits	70
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

LBC_HUMAN
θ value	1.9326e-10 (rank : 49)	NC score	0.542542 (rank : 45)
Query Neighborhood Hits	249	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

OBSCN_HUMAN
θ value	1.9326e-10 (rank : 50)	NC score	0.109240 (rank : 120)
Query Neighborhood Hits	249	Target Neighborhood Hits	1931	Shared Neighborhood Hits	88
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

MCF2_HUMAN
θ value	2.52405e-10 (rank : 51)	NC score	0.610551 (rank : 25)
Query Neighborhood Hits	249	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHG9_MOUSE
θ value	3.29651e-10 (rank : 52)	NC score	0.627327 (rank : 22)
Query Neighborhood Hits	249	Target Neighborhood Hits	234	Shared Neighborhood Hits	70
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ABR_HUMAN
θ value	5.62301e-10 (rank : 53)	NC score	0.423757 (rank : 71)
Query Neighborhood Hits	249	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ARHGC_HUMAN
θ value	9.59137e-10 (rank : 54)	NC score	0.511194 (rank : 52)
Query Neighborhood Hits	249	Target Neighborhood Hits	351	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

EEA1_MOUSE
θ value	1.25267e-09 (rank : 55)	NC score	0.173759 (rank : 109)
Query Neighborhood Hits	249	Target Neighborhood Hits	1637	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

SOS2_HUMAN
θ value	1.25267e-09 (rank : 56)	NC score	0.331228 (rank : 85)
Query Neighborhood Hits	249	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

BCR_HUMAN
θ value	1.63604e-09 (rank : 57)	NC score	0.422045 (rank : 74)
Query Neighborhood Hits	249	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

ARHG1_MOUSE
θ value	2.13673e-09 (rank : 58)	NC score	0.545154 (rank : 43)
Query Neighborhood Hits	249	Target Neighborhood Hits	266	Shared Neighborhood Hits	81
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

PKHF2_HUMAN
θ value	4.76016e-09 (rank : 59)	NC score	0.575385 (rank : 31)
Query Neighborhood Hits	249	Target Neighborhood Hits	75	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

ARHG7_MOUSE
θ value	8.11959e-09 (rank : 60)	NC score	0.451900 (rank : 64)
Query Neighborhood Hits	249	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

EEA1_HUMAN
θ value	8.11959e-09 (rank : 61)	NC score	0.161599 (rank : 111)
Query Neighborhood Hits	249	Target Neighborhood Hits	1796	Shared Neighborhood Hits	86
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ARHG7_HUMAN
θ value	1.06045e-08 (rank : 62)	NC score	0.469293 (rank : 58)
Query Neighborhood Hits	249	Target Neighborhood Hits	347	Shared Neighborhood Hits	74
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

PKHF2_MOUSE
θ value	1.38499e-08 (rank : 63)	NC score	0.574849 (rank : 32)
Query Neighborhood Hits	249	Target Neighborhood Hits	77	Shared Neighborhood Hits	57
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

DNMBP_MOUSE
θ value	3.08544e-08 (rank : 64)	NC score	0.450104 (rank : 65)
Query Neighborhood Hits	249	Target Neighborhood Hits	435	Shared Neighborhood Hits	70
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHGG_HUMAN
θ value	4.0297e-08 (rank : 65)	NC score	0.621317 (rank : 24)
Query Neighborhood Hits	249	Target Neighborhood Hits	129	Shared Neighborhood Hits	67
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

DNMBP_HUMAN
θ value	6.87365e-08 (rank : 66)	NC score	0.431767 (rank : 68)
Query Neighborhood Hits	249	Target Neighborhood Hits	413	Shared Neighborhood Hits	72
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

PKHG4_HUMAN
θ value	8.97725e-08 (rank : 67)	NC score	0.519556 (rank : 49)
Query Neighborhood Hits	249	Target Neighborhood Hits	200	Shared Neighborhood Hits	69
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

RUFY2_HUMAN
θ value	8.97725e-08 (rank : 68)	NC score	0.209522 (rank : 105)
Query Neighborhood Hits	249	Target Neighborhood Hits	1208	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TIAM1_MOUSE
θ value	8.97725e-08 (rank : 69)	NC score	0.567255 (rank : 34)
Query Neighborhood Hits	249	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ARHG3_HUMAN
θ value	1.17247e-07 (rank : 70)	NC score	0.553964 (rank : 40)
Query Neighborhood Hits	249	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	1.17247e-07 (rank : 71)	NC score	0.554993 (rank : 39)
Query Neighborhood Hits	249	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHGG_MOUSE
θ value	1.17247e-07 (rank : 72)	NC score	0.600470 (rank : 28)
Query Neighborhood Hits	249	Target Neighborhood Hits	152	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SOS1_HUMAN
θ value	1.17247e-07 (rank : 73)	NC score	0.327049 (rank : 86)
Query Neighborhood Hits	249	Target Neighborhood Hits	274	Shared Neighborhood Hits	40
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

WDFY3_HUMAN
θ value	1.17247e-07 (rank : 74)	NC score	0.259990 (rank : 95)
Query Neighborhood Hits	249	Target Neighborhood Hits	348	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	1.17247e-07 (rank : 75)	NC score	0.260137 (rank : 94)
Query Neighborhood Hits	249	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

SOS1_MOUSE
θ value	5.81887e-07 (rank : 76)	NC score	0.307848 (rank : 88)
Query Neighborhood Hits	249	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ZFY16_HUMAN
θ value	5.81887e-07 (rank : 77)	NC score	0.422982 (rank : 73)
Query Neighborhood Hits	249	Target Neighborhood Hits	125	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

PKHF1_HUMAN
θ value	1.69304e-06 (rank : 78)	NC score	0.560005 (rank : 37)
Query Neighborhood Hits	249	Target Neighborhood Hits	76	Shared Neighborhood Hits	61
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	1.69304e-06 (rank : 79)	NC score	0.556525 (rank : 38)
Query Neighborhood Hits	249	Target Neighborhood Hits	80	Shared Neighborhood Hits	59
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

TIAM1_HUMAN
θ value	3.77169e-06 (rank : 80)	NC score	0.563727 (rank : 36)
Query Neighborhood Hits	249	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ZFY16_MOUSE
θ value	3.77169e-06 (rank : 81)	NC score	0.429793 (rank : 69)
Query Neighborhood Hits	249	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

FYCO1_HUMAN
θ value	8.40245e-06 (rank : 82)	NC score	0.174061 (rank : 108)
Query Neighborhood Hits	249	Target Neighborhood Hits	1149	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

ZFYV9_HUMAN
θ value	1.09739e-05 (rank : 83)	NC score	0.439806 (rank : 66)
Query Neighborhood Hits	249	Target Neighborhood Hits	134	Shared Neighborhood Hits	56
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

RUFY2_MOUSE
θ value	1.43324e-05 (rank : 84)	NC score	0.250287 (rank : 97)
Query Neighborhood Hits	249	Target Neighborhood Hits	820	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

HGS_HUMAN
θ value	2.44474e-05 (rank : 85)	NC score	0.340079 (rank : 83)
Query Neighborhood Hits	249	Target Neighborhood Hits	517	Shared Neighborhood Hits	63
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	2.44474e-05 (rank : 86)	NC score	0.340204 (rank : 82)
Query Neighborhood Hits	249	Target Neighborhood Hits	589	Shared Neighborhood Hits	64
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

RBNS5_HUMAN
θ value	2.44474e-05 (rank : 87)	NC score	0.344027 (rank : 81)
Query Neighborhood Hits	249	Target Neighborhood Hits	242	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	2.44474e-05 (rank : 88)	NC score	0.339802 (rank : 84)
Query Neighborhood Hits	249	Target Neighborhood Hits	266	Shared Neighborhood Hits	56
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

ARHG8_HUMAN
θ value	9.29e-05 (rank : 89)	NC score	0.545677 (rank : 41)
Query Neighborhood Hits	249	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FYCO1_MOUSE
θ value	9.29e-05 (rank : 90)	NC score	0.162485 (rank : 110)
Query Neighborhood Hits	249	Target Neighborhood Hits	1059	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

FYV1_HUMAN
θ value	0.000121331 (rank : 91)	NC score	0.289472 (rank : 91)
Query Neighborhood Hits	249	Target Neighborhood Hits	217	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

RUFY1_MOUSE
θ value	0.000121331 (rank : 92)	NC score	0.247896 (rank : 98)
Query Neighborhood Hits	249	Target Neighborhood Hits	765	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

MTMR3_HUMAN
θ value	0.000158464 (rank : 93)	NC score	0.233540 (rank : 101)
Query Neighborhood Hits	249	Target Neighborhood Hits	163	Shared Neighborhood Hits	55
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

RUFY1_HUMAN
θ value	0.000270298 (rank : 94)	NC score	0.242950 (rank : 99)
Query Neighborhood Hits	249	Target Neighborhood Hits	848	Shared Neighborhood Hits	72
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

ZFY21_MOUSE
θ value	0.000270298 (rank : 95)	NC score	0.436807 (rank : 67)
Query Neighborhood Hits	249	Target Neighborhood Hits	72	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ANFY1_MOUSE
θ value	0.000461057 (rank : 96)	NC score	0.161248 (rank : 112)
Query Neighborhood Hits	249	Target Neighborhood Hits	480	Shared Neighborhood Hits	58
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

WDFY1_HUMAN
θ value	0.000461057 (rank : 97)	NC score	0.255854 (rank : 96)
Query Neighborhood Hits	249	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

ZFY28_HUMAN
θ value	0.000461057 (rank : 98)	NC score	0.454668 (rank : 63)
Query Neighborhood Hits	249	Target Neighborhood Hits	152	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ANFY1_HUMAN
θ value	0.000602161 (rank : 99)	NC score	0.160854 (rank : 113)
Query Neighborhood Hits	249	Target Neighborhood Hits	480	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ARHG8_MOUSE
θ value	0.000602161 (rank : 100)	NC score	0.476597 (rank : 55)
Query Neighborhood Hits	249	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

FYV1_MOUSE
θ value	0.000602161 (rank : 101)	NC score	0.286175 (rank : 93)
Query Neighborhood Hits	249	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

ZFY21_HUMAN
θ value	0.000786445 (rank : 102)	NC score	0.428783 (rank : 70)
Query Neighborhood Hits	249	Target Neighborhood Hits	72	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

WDFY2_HUMAN
θ value	0.00134147 (rank : 103)	NC score	0.233259 (rank : 102)
Query Neighborhood Hits	249	Target Neighborhood Hits	332	Shared Neighborhood Hits	51
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	0.00134147 (rank : 104)	NC score	0.234932 (rank : 100)
Query Neighborhood Hits	249	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

PGCA_HUMAN
θ value	0.0148317 (rank : 105)	NC score	0.023621 (rank : 294)
Query Neighborhood Hits	249	Target Neighborhood Hits	821	Shared Neighborhood Hits	29
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

CHD1_MOUSE
θ value	0.0252991 (rank : 106)	NC score	0.013531 (rank : 312)
Query Neighborhood Hits	249	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

AKAP2_HUMAN
θ value	0.0330416 (rank : 107)	NC score	0.044047 (rank : 258)
Query Neighborhood Hits	249	Target Neighborhood Hits	507	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

HAIR_MOUSE
θ value	0.0563607 (rank : 108)	NC score	0.028991 (rank : 286)
Query Neighborhood Hits	249	Target Neighborhood Hits	97	Shared Neighborhood Hits	7
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

TCOF_MOUSE
θ value	0.0563607 (rank : 109)	NC score	0.038811 (rank : 267)
Query Neighborhood Hits	249	Target Neighborhood Hits	471	Shared Neighborhood Hits	28
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

ZFYV1_HUMAN
θ value	0.0563607 (rank : 110)	NC score	0.310819 (rank : 87)
Query Neighborhood Hits	249	Target Neighborhood Hits	166	Shared Neighborhood Hits	56
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
θ value	0.0563607 (rank : 111)	NC score	0.307665 (rank : 89)
Query Neighborhood Hits	249	Target Neighborhood Hits	153	Shared Neighborhood Hits	60
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

CEL_HUMAN
θ value	0.0736092 (rank : 112)	NC score	0.018969 (rank : 301)
Query Neighborhood Hits	249	Target Neighborhood Hits	896	Shared Neighborhood Hits	47
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

CO1A1_MOUSE
θ value	0.0736092 (rank : 113)	NC score	0.050144 (rank : 252)
Query Neighborhood Hits	249	Target Neighborhood Hits	457	Shared Neighborhood Hits	39
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

PAK4_HUMAN
θ value	0.0736092 (rank : 114)	NC score	0.004042 (rank : 347)
Query Neighborhood Hits	249	Target Neighborhood Hits	924	Shared Neighborhood Hits	15
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

ZFY27_HUMAN
θ value	0.0736092 (rank : 115)	NC score	0.190999 (rank : 107)
Query Neighborhood Hits	249	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
θ value	0.0736092 (rank : 116)	NC score	0.198470 (rank : 106)
Query Neighborhood Hits	249	Target Neighborhood Hits	53	Shared Neighborhood Hits	45
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ALS2_MOUSE
θ value	0.125558 (rank : 117)	NC score	0.116375 (rank : 117)
Query Neighborhood Hits	249	Target Neighborhood Hits	111	Shared Neighborhood Hits	20
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

APC_HUMAN
θ value	0.125558 (rank : 118)	NC score	0.028923 (rank : 287)
Query Neighborhood Hits	249	Target Neighborhood Hits	603	Shared Neighborhood Hits	20
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

CD19_HUMAN
θ value	0.125558 (rank : 119)	NC score	0.033267 (rank : 276)
Query Neighborhood Hits	249	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	P15391, Q96S68, Q9BRD6	Gene names	CD19
Domain Architecture
Description	B-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B- lymphocyte surface antigen B4) (Leu-12).

CO1A1_HUMAN
θ value	0.125558 (rank : 120)	NC score	0.047190 (rank : 254)
Query Neighborhood Hits	249	Target Neighborhood Hits	475	Shared Neighborhood Hits	38
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

OPTN_MOUSE
θ value	0.125558 (rank : 121)	NC score	0.034815 (rank : 270)
Query Neighborhood Hits	249	Target Neighborhood Hits	1120	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

SGIP1_HUMAN
θ value	0.125558 (rank : 122)	NC score	0.031340 (rank : 280)
Query Neighborhood Hits	249	Target Neighborhood Hits	198	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

AP1B1_MOUSE
θ value	0.163984 (rank : 123)	NC score	0.012806 (rank : 315)
Query Neighborhood Hits	249	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

GCYB2_HUMAN
θ value	0.163984 (rank : 124)	NC score	0.016409 (rank : 304)
Query Neighborhood Hits	249	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

ZFY19_HUMAN
θ value	0.163984 (rank : 125)	NC score	0.295836 (rank : 90)
Query Neighborhood Hits	249	Target Neighborhood Hits	206	Shared Neighborhood Hits	59
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	0.163984 (rank : 126)	NC score	0.289353 (rank : 92)
Query Neighborhood Hits	249	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

CO3A1_MOUSE
θ value	0.21417 (rank : 127)	NC score	0.052877 (rank : 225)
Query Neighborhood Hits	249	Target Neighborhood Hits	466	Shared Neighborhood Hits	45
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO5A1_MOUSE
θ value	0.21417 (rank : 128)	NC score	0.052098 (rank : 233)
Query Neighborhood Hits	249	Target Neighborhood Hits	419	Shared Neighborhood Hits	36
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

CO5A3_HUMAN
θ value	0.21417 (rank : 129)	NC score	0.042408 (rank : 260)
Query Neighborhood Hits	249	Target Neighborhood Hits	433	Shared Neighborhood Hits	40
SwissProt Accessions	P25940, Q9NZQ6	Gene names	COL5A3
Domain Architecture
Description	Collagen alpha-3(V) chain precursor.

K0323_MOUSE
θ value	0.21417 (rank : 130)	NC score	0.025360 (rank : 290)
Query Neighborhood Hits	249	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q80U38, Q8BGJ6, Q8C082	Gene names	Kiaa0323
Domain Architecture	No domain graphic available
Description	Protein KIAA0323.

RNF37_MOUSE
θ value	0.21417 (rank : 131)	NC score	0.035923 (rank : 269)
Query Neighborhood Hits	249	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q925F4	Gene names	Ubox5, Rnf37, Ubce7ip5, Uip5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (UbcM4-interacting protein 5) (U-box domain-containing protein 5).

SRRM2_MOUSE
θ value	0.21417 (rank : 132)	NC score	0.025297 (rank : 291)
Query Neighborhood Hits	249	Target Neighborhood Hits	1470	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ARI3A_HUMAN
θ value	0.279714 (rank : 133)	NC score	0.023702 (rank : 293)
Query Neighborhood Hits	249	Target Neighborhood Hits	80	Shared Neighborhood Hits	4
SwissProt Accessions	Q99856, Q8IZA7	Gene names	ARID3A, DRIL1, DRX, E2FBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (E2F-binding protein 1).

OGFR_MOUSE
θ value	0.279714 (rank : 134)	NC score	0.042630 (rank : 259)
Query Neighborhood Hits	249	Target Neighborhood Hits	584	Shared Neighborhood Hits	37
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

CO5A1_HUMAN
θ value	0.365318 (rank : 135)	NC score	0.051109 (rank : 246)
Query Neighborhood Hits	249	Target Neighborhood Hits	434	Shared Neighborhood Hits	38
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

COBA2_MOUSE
θ value	0.365318 (rank : 136)	NC score	0.041560 (rank : 264)
Query Neighborhood Hits	249	Target Neighborhood Hits	501	Shared Neighborhood Hits	43
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

RNF34_HUMAN
θ value	0.365318 (rank : 137)	NC score	0.065807 (rank : 181)
Query Neighborhood Hits	249	Target Neighborhood Hits	153	Shared Neighborhood Hits	34
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

COBA2_HUMAN
θ value	0.47712 (rank : 138)	NC score	0.041573 (rank : 263)
Query Neighborhood Hits	249	Target Neighborhood Hits	408	Shared Neighborhood Hits	42
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

RNF34_MOUSE
θ value	0.47712 (rank : 139)	NC score	0.068507 (rank : 172)
Query Neighborhood Hits	249	Target Neighborhood Hits	160	Shared Neighborhood Hits	36
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

CO3A1_HUMAN
θ value	0.62314 (rank : 140)	NC score	0.052828 (rank : 226)
Query Neighborhood Hits	249	Target Neighborhood Hits	452	Shared Neighborhood Hits	42
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

DTBP1_HUMAN
θ value	0.62314 (rank : 141)	NC score	0.025511 (rank : 289)
Query Neighborhood Hits	249	Target Neighborhood Hits	185	Shared Neighborhood Hits	9
SwissProt Accessions	Q96EV8, Q96NV2, Q9H0U2, Q9H3J5	Gene names	DTNBP1
Domain Architecture
Description	Dystrobrevin-binding protein 1 (Dysbindin) (Hermansky-Pudlak syndrome 7 protein).

PKHA2_HUMAN
θ value	0.62314 (rank : 142)	NC score	0.056382 (rank : 211)
Query Neighborhood Hits	249	Target Neighborhood Hits	119	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

SYTL5_MOUSE
θ value	0.62314 (rank : 143)	NC score	0.021641 (rank : 296)
Query Neighborhood Hits	249	Target Neighborhood Hits	154	Shared Neighborhood Hits	12
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

ZIMP7_HUMAN
θ value	0.62314 (rank : 144)	NC score	0.018761 (rank : 302)
Query Neighborhood Hits	249	Target Neighborhood Hits	290	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

LCOR_HUMAN
θ value	0.813845 (rank : 145)	NC score	0.020806 (rank : 298)
Query Neighborhood Hits	249	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JN0, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6	Gene names	LCOR, KIAA1795, MLR2
Domain Architecture	No domain graphic available
Description	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2).

MAML1_MOUSE
θ value	0.813845 (rank : 146)	NC score	0.019283 (rank : 300)
Query Neighborhood Hits	249	Target Neighborhood Hits	279	Shared Neighborhood Hits	22
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

ZBTB1_HUMAN
θ value	0.813845 (rank : 147)	NC score	0.004144 (rank : 345)
Query Neighborhood Hits	249	Target Neighborhood Hits	805	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y2K1, Q86SW8	Gene names	ZBTB1, KIAA0997
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ZN433_HUMAN
θ value	0.813845 (rank : 148)	NC score	0.002019 (rank : 355)
Query Neighborhood Hits	249	Target Neighborhood Hits	782	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N7K0	Gene names	ZNF433
Domain Architecture
Description	Zinc finger protein 433.

ZN440_HUMAN
θ value	0.813845 (rank : 149)	NC score	0.002585 (rank : 351)
Query Neighborhood Hits	249	Target Neighborhood Hits	750	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IYI8, Q8N1R9	Gene names	ZNF440
Domain Architecture
Description	Zinc finger protein 440.

CO1A2_MOUSE
θ value	1.06291 (rank : 150)	NC score	0.047061 (rank : 255)
Query Neighborhood Hits	249	Target Neighborhood Hits	388	Shared Neighborhood Hits	42
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

COBA1_HUMAN
θ value	1.06291 (rank : 151)	NC score	0.042216 (rank : 261)
Query Neighborhood Hits	249	Target Neighborhood Hits	491	Shared Neighborhood Hits	40
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COBA1_MOUSE
θ value	1.06291 (rank : 152)	NC score	0.041930 (rank : 262)
Query Neighborhood Hits	249	Target Neighborhood Hits	487	Shared Neighborhood Hits	40
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

GBF1_HUMAN
θ value	1.06291 (rank : 153)	NC score	0.010288 (rank : 323)
Query Neighborhood Hits	249	Target Neighborhood Hits	142	Shared Neighborhood Hits	3
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

WNK2_HUMAN
θ value	1.06291 (rank : 154)	NC score	0.004770 (rank : 344)
Query Neighborhood Hits	249	Target Neighborhood Hits	1407	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

CO5A2_HUMAN
θ value	1.38821 (rank : 155)	NC score	0.036415 (rank : 268)
Query Neighborhood Hits	249	Target Neighborhood Hits	760	Shared Neighborhood Hits	50
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

FMN2_HUMAN
θ value	1.38821 (rank : 156)	NC score	0.016072 (rank : 305)
Query Neighborhood Hits	249	Target Neighborhood Hits	484	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

MBD6_HUMAN
θ value	1.38821 (rank : 157)	NC score	0.023982 (rank : 292)
Query Neighborhood Hits	249	Target Neighborhood Hits	349	Shared Neighborhood Hits	17
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

PELP1_HUMAN
θ value	1.38821 (rank : 158)	NC score	0.019655 (rank : 299)
Query Neighborhood Hits	249	Target Neighborhood Hits	596	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PRGR_HUMAN
θ value	1.38821 (rank : 159)	NC score	0.002667 (rank : 350)
Query Neighborhood Hits	249	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

VEZA_HUMAN
θ value	1.38821 (rank : 160)	NC score	0.030749 (rank : 283)
Query Neighborhood Hits	249	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HBM0, Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91	Gene names	VEZT
Domain Architecture	No domain graphic available
Description	Vezatin.

ZBT40_HUMAN
θ value	1.38821 (rank : 161)	NC score	0.005252 (rank : 342)
Query Neighborhood Hits	249	Target Neighborhood Hits	949	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

ZN691_MOUSE
θ value	1.38821 (rank : 162)	NC score	0.001506 (rank : 360)
Query Neighborhood Hits	249	Target Neighborhood Hits	745	Shared Neighborhood Hits	30
SwissProt Accessions	Q3TDE8, Q3TAT2, Q8BIB1	Gene names	Znf691, Zfp691
Domain Architecture	No domain graphic available
Description	Zinc finger protein 691.

CO002_HUMAN
θ value	1.81305 (rank : 163)	NC score	0.032912 (rank : 278)
Query Neighborhood Hits	249	Target Neighborhood Hits	387	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

CO1A2_HUMAN
θ value	1.81305 (rank : 164)	NC score	0.045942 (rank : 256)
Query Neighborhood Hits	249	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO2A1_MOUSE
θ value	1.81305 (rank : 165)	NC score	0.044777 (rank : 257)
Query Neighborhood Hits	249	Target Neighborhood Hits	483	Shared Neighborhood Hits	44
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

HAIR_HUMAN
θ value	1.81305 (rank : 166)	NC score	0.022975 (rank : 295)
Query Neighborhood Hits	249	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

MELPH_MOUSE
θ value	1.81305 (rank : 167)	NC score	0.066777 (rank : 176)
Query Neighborhood Hits	249	Target Neighborhood Hits	112	Shared Neighborhood Hits	16
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

SALL3_HUMAN
θ value	1.81305 (rank : 168)	NC score	0.009669 (rank : 324)
Query Neighborhood Hits	249	Target Neighborhood Hits	1066	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

SPRE2_MOUSE
θ value	1.81305 (rank : 169)	NC score	0.016959 (rank : 303)
Query Neighborhood Hits	249	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

ZEP2_HUMAN
θ value	1.81305 (rank : 170)	NC score	0.004062 (rank : 346)
Query Neighborhood Hits	249	Target Neighborhood Hits	937	Shared Neighborhood Hits	35
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

ZN442_HUMAN
θ value	1.81305 (rank : 171)	NC score	0.001721 (rank : 357)
Query Neighborhood Hits	249	Target Neighborhood Hits	744	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H7R0	Gene names	ZNF442
Domain Architecture
Description	Zinc finger protein 442.

ZN563_HUMAN
θ value	1.81305 (rank : 172)	NC score	0.002260 (rank : 353)
Query Neighborhood Hits	249	Target Neighborhood Hits	754	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TA94, Q8NAT7	Gene names	ZNF563
Domain Architecture	No domain graphic available
Description	Zinc finger protein 563.

FA13A_MOUSE
θ value	2.36792 (rank : 173)	NC score	0.015248 (rank : 308)
Query Neighborhood Hits	249	Target Neighborhood Hits	83	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

ILF3_MOUSE
θ value	2.36792 (rank : 174)	NC score	0.011984 (rank : 316)
Query Neighborhood Hits	249	Target Neighborhood Hits	71	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1X4, Q80VD5, Q812A1, Q8BP80, Q8C2H8, Q8K588	Gene names	Ilf3
Domain Architecture
Description	Interleukin enhancer-binding factor 3.

RENT2_HUMAN
θ value	2.36792 (rank : 175)	NC score	0.031080 (rank : 281)
Query Neighborhood Hits	249	Target Neighborhood Hits	618	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

RNF31_HUMAN
θ value	2.36792 (rank : 176)	NC score	0.014979 (rank : 309)
Query Neighborhood Hits	249	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

ZN136_HUMAN
θ value	2.36792 (rank : 177)	NC score	0.001862 (rank : 356)
Query Neighborhood Hits	249	Target Neighborhood Hits	739	Shared Neighborhood Hits	32
SwissProt Accessions	P52737	Gene names	ZNF136
Domain Architecture
Description	Zinc finger protein 136.

ASCL1_HUMAN
θ value	3.0926 (rank : 178)	NC score	0.009602 (rank : 326)
Query Neighborhood Hits	249	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

ASPX_HUMAN
θ value	3.0926 (rank : 179)	NC score	0.014774 (rank : 310)
Query Neighborhood Hits	249	Target Neighborhood Hits	148	Shared Neighborhood Hits	9
SwissProt Accessions	P26436	Gene names	ACRV1
Domain Architecture
Description	Acrosomal protein SP-10 precursor (Acrosomal vesicle protein 1).

CENB5_HUMAN
θ value	3.0926 (rank : 180)	NC score	0.034385 (rank : 273)
Query Neighborhood Hits	249	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CHD1_HUMAN
θ value	3.0926 (rank : 181)	NC score	0.009558 (rank : 327)
Query Neighborhood Hits	249	Target Neighborhood Hits	337	Shared Neighborhood Hits	12
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

EGLN1_HUMAN
θ value	3.0926 (rank : 182)	NC score	0.009297 (rank : 328)
Query Neighborhood Hits	249	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZT9, Q8N3M8, Q9BZS8, Q9BZT0	Gene names	EGLN1, C1orf12
Domain Architecture
Description	Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20).

ERC2_MOUSE
θ value	3.0926 (rank : 183)	NC score	0.031937 (rank : 279)
Query Neighborhood Hits	249	Target Neighborhood Hits	1166	Shared Neighborhood Hits	32
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

NCA11_MOUSE
θ value	3.0926 (rank : 184)	NC score	0.009151 (rank : 329)
Query Neighborhood Hits	249	Target Neighborhood Hits	661	Shared Neighborhood Hits	13
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

RNF6_HUMAN
θ value	3.0926 (rank : 185)	NC score	0.007491 (rank : 334)
Query Neighborhood Hits	249	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

ZBT7B_MOUSE
θ value	3.0926 (rank : 186)	NC score	0.001041 (rank : 364)
Query Neighborhood Hits	249	Target Neighborhood Hits	792	Shared Neighborhood Hits	29
SwissProt Accessions	Q64321, Q80VV5	Gene names	Zbtb7b, Thpok, Zfp67
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 7B (Zinc finger protein 67) (Zfp-67) (Zinc finger protein Th-POK) (T-helper-inducing POZ/Krueppel-like factor) (Krueppel-related zinc finger protein cKrox) (c-Krox).

ZBTB1_MOUSE
θ value	3.0926 (rank : 187)	NC score	0.002579 (rank : 352)
Query Neighborhood Hits	249	Target Neighborhood Hits	795	Shared Neighborhood Hits	30
SwissProt Accessions	Q91VL9, Q8CDP7, Q99LD2	Gene names	Zbtb1
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ZIM3_HUMAN
θ value	3.0926 (rank : 188)	NC score	0.001364 (rank : 362)
Query Neighborhood Hits	249	Target Neighborhood Hits	765	Shared Neighborhood Hits	29
SwissProt Accessions	Q96PE6	Gene names	ZIM3
Domain Architecture
Description	Zinc finger imprinted 3.

3BP5_MOUSE
θ value	4.03905 (rank : 189)	NC score	0.015579 (rank : 307)
Query Neighborhood Hits	249	Target Neighborhood Hits	346	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

CEBPD_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.008296 (rank : 331)
Query Neighborhood Hits	249	Target Neighborhood Hits	135	Shared Neighborhood Hits	8
SwissProt Accessions	P49716, Q14937	Gene names	CEBPD
Domain Architecture
Description	CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF- IL6-beta) (NF-IL6-beta).

CO4A3_HUMAN
θ value	4.03905 (rank : 191)	NC score	0.034387 (rank : 272)
Query Neighborhood Hits	249	Target Neighborhood Hits	421	Shared Neighborhood Hits	37
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

ELN_MOUSE
θ value	4.03905 (rank : 192)	NC score	0.033470 (rank : 274)
Query Neighborhood Hits	249	Target Neighborhood Hits	105	Shared Neighborhood Hits	23
SwissProt Accessions	P54320	Gene names	Eln
Domain Architecture	No domain graphic available
Description	Elastin precursor (Tropoelastin).

ERC2_HUMAN
θ value	4.03905 (rank : 193)	NC score	0.029871 (rank : 284)
Query Neighborhood Hits	249	Target Neighborhood Hits	1156	Shared Neighborhood Hits	30
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

HIC1_MOUSE
θ value	4.03905 (rank : 194)	NC score	0.001292 (rank : 363)
Query Neighborhood Hits	249	Target Neighborhood Hits	863	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

MYO9B_MOUSE
θ value	4.03905 (rank : 195)	NC score	0.011326 (rank : 318)
Query Neighborhood Hits	249	Target Neighborhood Hits	311	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

PKHA2_MOUSE
θ value	4.03905 (rank : 196)	NC score	0.060568 (rank : 197)
Query Neighborhood Hits	249	Target Neighborhood Hits	116	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

SCAR3_HUMAN
θ value	4.03905 (rank : 197)	NC score	0.034614 (rank : 271)
Query Neighborhood Hits	249	Target Neighborhood Hits	205	Shared Neighborhood Hits	33
SwissProt Accessions	Q6AZY7, Q9UM15, Q9UM16	Gene names	SCARA3, CSR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class A member 3 (Cellular stress response gene protein).

SPRE2_HUMAN
θ value	4.03905 (rank : 198)	NC score	0.010520 (rank : 320)
Query Neighborhood Hits	249	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z698, Q2NKX6	Gene names	SPRED2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

ZN599_HUMAN
θ value	4.03905 (rank : 199)	NC score	0.000661 (rank : 366)
Query Neighborhood Hits	249	Target Neighborhood Hits	744	Shared Neighborhood Hits	30
SwissProt Accessions	Q96NL3, Q569K0, Q5PRG1	Gene names	ZNF599
Domain Architecture	No domain graphic available
Description	Zinc finger protein 599.

ZNF70_HUMAN
θ value	4.03905 (rank : 200)	NC score	0.001640 (rank : 358)
Query Neighborhood Hits	249	Target Neighborhood Hits	760	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

3BP5_HUMAN
θ value	5.27518 (rank : 201)	NC score	0.014486 (rank : 311)
Query Neighborhood Hits	249	Target Neighborhood Hits	375	Shared Neighborhood Hits	8
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

ANKZ1_HUMAN
θ value	5.27518 (rank : 202)	NC score	0.011878 (rank : 317)
Query Neighborhood Hits	249	Target Neighborhood Hits	236	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

CDSN_MOUSE
θ value	5.27518 (rank : 203)	NC score	0.015718 (rank : 306)
Query Neighborhood Hits	249	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

CN140_MOUSE
θ value	5.27518 (rank : 204)	NC score	0.027799 (rank : 288)
Query Neighborhood Hits	249	Target Neighborhood Hits	152	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CCG1, Q8CCM8	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf140 homolog.

CO4A6_HUMAN
θ value	5.27518 (rank : 205)	NC score	0.033224 (rank : 277)
Query Neighborhood Hits	249	Target Neighborhood Hits	318	Shared Neighborhood Hits	35
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

DGKK_HUMAN
θ value	5.27518 (rank : 206)	NC score	0.039407 (rank : 266)
Query Neighborhood Hits	249	Target Neighborhood Hits	378	Shared Neighborhood Hits	24
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

EPHAA_HUMAN
θ value	5.27518 (rank : 207)	NC score	-0.000907 (rank : 375)
Query Neighborhood Hits	249	Target Neighborhood Hits	960	Shared Neighborhood Hits	14
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

IF39_MOUSE
θ value	5.27518 (rank : 208)	NC score	0.008273 (rank : 332)
Query Neighborhood Hits	249	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

MLH3_HUMAN
θ value	5.27518 (rank : 209)	NC score	0.009609 (rank : 325)
Query Neighborhood Hits	249	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHC1, P49751, Q56DK9, Q9P292, Q9UHC0	Gene names	MLH3
Domain Architecture
Description	DNA mismatch repair protein Mlh3 (MutL protein homolog 3).

PCAF_HUMAN
θ value	5.27518 (rank : 210)	NC score	0.003893 (rank : 348)
Query Neighborhood Hits	249	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q92831, Q6NSK1	Gene names	PCAF
Domain Architecture
Description	Histone acetyltransferase PCAF (EC 2.3.1.48) (P300/CBP-associated factor) (P/CAF) (Histone acetylase PCAF).

PGCA_MOUSE
θ value	5.27518 (rank : 211)	NC score	0.013359 (rank : 313)
Query Neighborhood Hits	249	Target Neighborhood Hits	643	Shared Neighborhood Hits	33
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

RU17_MOUSE
θ value	5.27518 (rank : 212)	NC score	0.005657 (rank : 339)
Query Neighborhood Hits	249	Target Neighborhood Hits	278	Shared Neighborhood Hits	11
SwissProt Accessions	Q62376, Q3UIW4	Gene names	Snrp70
Domain Architecture	No domain graphic available
Description	U1 small nuclear ribonucleoprotein 70 kDa (U1 SNRNP 70 kDa) (snRNP70).

SYTL4_HUMAN
θ value	5.27518 (rank : 213)	NC score	0.041509 (rank : 265)
Query Neighborhood Hits	249	Target Neighborhood Hits	138	Shared Neighborhood Hits	19
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

TRI32_HUMAN
θ value	5.27518 (rank : 214)	NC score	0.006031 (rank : 338)
Query Neighborhood Hits	249	Target Neighborhood Hits	264	Shared Neighborhood Hits	11
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

ZBP1_HUMAN
θ value	5.27518 (rank : 215)	NC score	0.010309 (rank : 322)
Query Neighborhood Hits	249	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H171, Q5JY39, Q9BYW4	Gene names	ZBP1, C20orf183, DLM1
Domain Architecture
Description	Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1).

ZFP14_MOUSE
θ value	5.27518 (rank : 216)	NC score	0.000134 (rank : 372)
Query Neighborhood Hits	249	Target Neighborhood Hits	746	Shared Neighborhood Hits	28
SwissProt Accessions	P10755, Q5DTW6, Q8BFZ5	Gene names	Zfp14, Kiaa1559, Krox-9, Zfp-14
Domain Architecture	No domain graphic available
Description	Zinc finger protein 14 (Zfp-14) (Krox-9 protein).

ZN224_HUMAN
θ value	5.27518 (rank : 217)	NC score	0.000130 (rank : 373)
Query Neighborhood Hits	249	Target Neighborhood Hits	808	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZL3, Q86V10, Q8IZC8, Q9UID9, Q9Y2P6	Gene names	ZNF224, BMZF2, ZNF255
Domain Architecture
Description	Zinc finger protein 224 (Zinc finger protein 255) (Bone marrow zinc finger 2) (BMZF-2).

ZN540_HUMAN
θ value	5.27518 (rank : 218)	NC score	0.000328 (rank : 369)
Query Neighborhood Hits	249	Target Neighborhood Hits	759	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NDQ6, Q6ZN36, Q7Z3C8, Q86T31	Gene names	ZNF540
Domain Architecture	No domain graphic available
Description	Zinc finger protein 540.

ZN691_HUMAN
θ value	5.27518 (rank : 219)	NC score	0.000336 (rank : 368)
Query Neighborhood Hits	249	Target Neighborhood Hits	745	Shared Neighborhood Hits	28
SwissProt Accessions	Q5VV52, O95878, Q9NWE8	Gene names	ZNF691
Domain Architecture	No domain graphic available
Description	Zinc finger protein 691.

ZN700_HUMAN
θ value	5.27518 (rank : 220)	NC score	0.001417 (rank : 361)
Query Neighborhood Hits	249	Target Neighborhood Hits	772	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H0M5	Gene names	ZNF700
Domain Architecture	No domain graphic available
Description	Zinc finger protein 700.

ZNF26_HUMAN
θ value	5.27518 (rank : 221)	NC score	0.000976 (rank : 365)
Query Neighborhood Hits	249	Target Neighborhood Hits	736	Shared Neighborhood Hits	29
SwissProt Accessions	P17031, Q9NWL3	Gene names	ZNF26, KOX20
Domain Architecture	No domain graphic available
Description	Zinc finger protein 26 (Zinc finger protein KOX20).

ASCL1_MOUSE
θ value	6.88961 (rank : 222)	NC score	0.007425 (rank : 335)
Query Neighborhood Hits	249	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

CJ006_MOUSE
θ value	6.88961 (rank : 223)	NC score	0.011100 (rank : 319)
Query Neighborhood Hits	249	Target Neighborhood Hits	141	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

DGKH_HUMAN
θ value	6.88961 (rank : 224)	NC score	0.065941 (rank : 180)
Query Neighborhood Hits	249	Target Neighborhood Hits	255	Shared Neighborhood Hits	29
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

DHX36_MOUSE
θ value	6.88961 (rank : 225)	NC score	0.003383 (rank : 349)
Query Neighborhood Hits	249	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VHK9, Q6ZPP7, Q9CSE8	Gene names	Dhx36, Ddx36, Kiaa1488, Mlel1
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX36 (EC 3.6.1.-) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).

EGLN2_HUMAN
θ value	6.88961 (rank : 226)	NC score	0.007988 (rank : 333)
Query Neighborhood Hits	249	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KS0, Q8WWY4, Q9BV14	Gene names	EGLN2, EIT6
Domain Architecture
Description	Egl nine homolog 2 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-prolyl hydroxylase 1) (HIF-PH1) (HPH-3) (Prolyl hydroxylase domain-containing protein 1) (PHD1) (Estrogen-induced tag 6).

FOXQ1_HUMAN
θ value	6.88961 (rank : 227)	NC score	-0.000159 (rank : 374)
Query Neighborhood Hits	249	Target Neighborhood Hits	115	Shared Neighborhood Hits	5
SwissProt Accessions	Q9C009, Q9NS06	Gene names	FOXQ1, HFH1
Domain Architecture
Description	Forkhead box protein Q1 (Hepatocyte nuclear factor 3 forkhead homolog 1) (HNF-3/forkhead-like protein 1) (HFH-1).

MAST1_MOUSE
θ value	6.88961 (rank : 228)	NC score	0.005022 (rank : 343)
Query Neighborhood Hits	249	Target Neighborhood Hits	1123	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

OGFR_HUMAN
θ value	6.88961 (rank : 229)	NC score	0.050696 (rank : 248)
Query Neighborhood Hits	249	Target Neighborhood Hits	1582	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RFFL_MOUSE
θ value	6.88961 (rank : 230)	NC score	0.066772 (rank : 177)
Query Neighborhood Hits	249	Target Neighborhood Hits	145	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

SHAN1_HUMAN
θ value	6.88961 (rank : 231)	NC score	0.057166 (rank : 205)
Query Neighborhood Hits	249	Target Neighborhood Hits	1041	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ZN140_HUMAN
θ value	6.88961 (rank : 232)	NC score	0.000198 (rank : 371)
Query Neighborhood Hits	249	Target Neighborhood Hits	741	Shared Neighborhood Hits	32
SwissProt Accessions	P52738	Gene names	ZNF140
Domain Architecture
Description	Zinc finger protein 140.

ZN222_HUMAN
θ value	6.88961 (rank : 233)	NC score	0.000270 (rank : 370)
Query Neighborhood Hits	249	Target Neighborhood Hits	747	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UK12, Q9P1U5	Gene names	ZNF222
Domain Architecture
Description	Zinc finger protein 222.

AIM1_HUMAN
θ value	8.99809 (rank : 234)	NC score	0.007336 (rank : 336)
Query Neighborhood Hits	249	Target Neighborhood Hits	247	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

CIC_HUMAN
θ value	8.99809 (rank : 235)	NC score	0.021289 (rank : 297)
Query Neighborhood Hits	249	Target Neighborhood Hits	992	Shared Neighborhood Hits	50
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CO8A2_HUMAN
θ value	8.99809 (rank : 236)	NC score	0.031077 (rank : 282)
Query Neighborhood Hits	249	Target Neighborhood Hits	299	Shared Neighborhood Hits	35
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

HIC2_MOUSE
θ value	8.99809 (rank : 237)	NC score	0.000388 (rank : 367)
Query Neighborhood Hits	249	Target Neighborhood Hits	821	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLZ6, Q3U030, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5	Gene names	Hic2, Kiaa1020
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2).

ILF3_HUMAN
θ value	8.99809 (rank : 238)	NC score	0.009004 (rank : 330)
Query Neighborhood Hits	249	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	Q12906, O43409, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2	Gene names	ILF3, DRBF, MPHOSPH4, NF90
Domain Architecture
Description	Interleukin enhancer-binding factor 3 (Nuclear factor of activated T- cells 90 kDa) (NF-AT-90) (Double-stranded RNA-binding protein 76) (DRBP76) (Translational control protein 80) (TCP80) (Nuclear factor associated with dsRNA) (NFAR) (M-phase phosphoprotein 4) (MPP4).

LEG3_MOUSE
θ value	8.99809 (rank : 239)	NC score	0.010505 (rank : 321)
Query Neighborhood Hits	249	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	P16110	Gene names	Lgals3
Domain Architecture
Description	Galectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-binding protein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Laminin-binding protein) (Lectin L-29) (L-34 galactoside-binding lectin).

MARCS_HUMAN
θ value	8.99809 (rank : 240)	NC score	0.005627 (rank : 340)
Query Neighborhood Hits	249	Target Neighborhood Hits	204	Shared Neighborhood Hits	10
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

RFFL_HUMAN
θ value	8.99809 (rank : 241)	NC score	0.057568 (rank : 204)
Query Neighborhood Hits	249	Target Neighborhood Hits	175	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

SALL1_MOUSE
θ value	8.99809 (rank : 242)	NC score	0.002072 (rank : 354)
Query Neighborhood Hits	249	Target Neighborhood Hits	826	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ER74, Q920R5	Gene names	Sall1, Sal3
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein Spalt-3) (Sal-3) (MSal-3).

SCAR3_MOUSE
θ value	8.99809 (rank : 243)	NC score	0.033344 (rank : 275)
Query Neighborhood Hits	249	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C850, Q8C6N1	Gene names	Scara3
Domain Architecture	No domain graphic available
Description	Scavenger receptor class A member 3.

SETBP_HUMAN
θ value	8.99809 (rank : 244)	NC score	0.013207 (rank : 314)
Query Neighborhood Hits	249	Target Neighborhood Hits	305	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SNIP_MOUSE
θ value	8.99809 (rank : 245)	NC score	0.005253 (rank : 341)
Query Neighborhood Hits	249	Target Neighborhood Hits	319	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

SWP70_MOUSE
θ value	8.99809 (rank : 246)	NC score	0.074622 (rank : 154)
Query Neighborhood Hits	249	Target Neighborhood Hits	1097	Shared Neighborhood Hits	49
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SYTL4_MOUSE
θ value	8.99809 (rank : 247)	NC score	0.029241 (rank : 285)
Query Neighborhood Hits	249	Target Neighborhood Hits	137	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

TGON1_MOUSE
θ value	8.99809 (rank : 248)	NC score	0.006680 (rank : 337)
Query Neighborhood Hits	249	Target Neighborhood Hits	243	Shared Neighborhood Hits	13
SwissProt Accessions	Q62313	Gene names	Tgoln1, Ttgn1
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 1 precursor (TGN38A).

ZNF14_HUMAN
θ value	8.99809 (rank : 249)	NC score	0.001580 (rank : 359)
Query Neighborhood Hits	249	Target Neighborhood Hits	760	Shared Neighborhood Hits	37
SwissProt Accessions	P17017, Q9ULZ5	Gene names	ZNF14, GIOT4, KOX6
Domain Architecture
Description	Zinc finger protein 14 (Zinc finger protein KOX6) (Gonadotropin- inducible transcription repressor 4) (GIOT-4).

3BP2_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.051363 (rank : 241)
Query Neighborhood Hits	249	Target Neighborhood Hits	296	Shared Neighborhood Hits	19
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

41_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.052602 (rank : 228)
Query Neighborhood Hits	249	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

41_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.051377 (rank : 240)
Query Neighborhood Hits	249	Target Neighborhood Hits	184	Shared Neighborhood Hits	6
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

ABI1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.065585 (rank : 182)
Query Neighborhood Hits	249	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.070590 (rank : 166)
Query Neighborhood Hits	249	Target Neighborhood Hits	246	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.074348 (rank : 155)
Query Neighborhood Hits	249	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.072577 (rank : 161)
Query Neighborhood Hits	249	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.065518 (rank : 183)
Query Neighborhood Hits	249	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.064490 (rank : 187)
Query Neighborhood Hits	249	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.066440 (rank : 179)
Query Neighborhood Hits	249	Target Neighborhood Hits	537	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.060604 (rank : 195)
Query Neighborhood Hits	249	Target Neighborhood Hits	496	Shared Neighborhood Hits	27
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ALS2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.094819 (rank : 129)
Query Neighborhood Hits	249	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

ANM2_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.053090 (rank : 223)
Query Neighborhood Hits	249	Target Neighborhood Hits	175	Shared Neighborhood Hits	17
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG6_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.384922 (rank : 79)
Query Neighborhood Hits	249	Target Neighborhood Hits	376	Shared Neighborhood Hits	62
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.347868 (rank : 80)
Query Neighborhood Hits	249	Target Neighborhood Hits	394	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHGF_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.543980 (rank : 44)
Query Neighborhood Hits	249	Target Neighborhood Hits	214	Shared Neighborhood Hits	67
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ASPP1_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.053200 (rank : 222)
Query Neighborhood Hits	249	Target Neighborhood Hits	1244	Shared Neighborhood Hits	59
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.054364 (rank : 218)
Query Neighborhood Hits	249	Target Neighborhood Hits	554	Shared Neighborhood Hits	32
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.054697 (rank : 216)
Query Neighborhood Hits	249	Target Neighborhood Hits	438	Shared Neighborhood Hits	28
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BI2L1_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.071421 (rank : 163)
Query Neighborhood Hits	249	Target Neighborhood Hits	156	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.056704 (rank : 210)
Query Neighborhood Hits	249	Target Neighborhood Hits	197	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CASL_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.050459 (rank : 250)
Query Neighborhood Hits	249	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CD2AP_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.107551 (rank : 121)
Query Neighborhood Hits	249	Target Neighborhood Hits	315	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 273)	NC score	0.106082 (rank : 123)
Query Neighborhood Hits	249	Target Neighborhood Hits	336	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CNKR1_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.055674 (rank : 213)
Query Neighborhood Hits	249	Target Neighborhood Hits	154	Shared Neighborhood Hits	19
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CRKL_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.073372 (rank : 159)
Query Neighborhood Hits	249	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.071401 (rank : 164)
Query Neighborhood Hits	249	Target Neighborhood Hits	307	Shared Neighborhood Hits	19
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.067397 (rank : 175)
Query Neighborhood Hits	249	Target Neighborhood Hits	308	Shared Neighborhood Hits	20
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.070856 (rank : 165)
Query Neighborhood Hits	249	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DBNL_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.060187 (rank : 199)
Query Neighborhood Hits	249	Target Neighborhood Hits	244	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.058762 (rank : 201)
Query Neighborhood Hits	249	Target Neighborhood Hits	306	Shared Neighborhood Hits	18
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DGKD_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.050909 (rank : 247)
Query Neighborhood Hits	249	Target Neighborhood Hits	231	Shared Neighborhood Hits	23
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

E41L1_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.051739 (rank : 238)
Query Neighborhood Hits	249	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L1_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.051260 (rank : 243)
Query Neighborhood Hits	249	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.051211 (rank : 244)
Query Neighborhood Hits	249	Target Neighborhood Hits	287	Shared Neighborhood Hits	8
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L2_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.052012 (rank : 235)
Query Neighborhood Hits	249	Target Neighborhood Hits	459	Shared Neighborhood Hits	12
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.053473 (rank : 221)
Query Neighborhood Hits	249	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

E41L3_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.052003 (rank : 236)
Query Neighborhood Hits	249	Target Neighborhood Hits	250	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

E41L5_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.053542 (rank : 219)
Query Neighborhood Hits	249	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.054934 (rank : 214)
Query Neighborhood Hits	249	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

E41LB_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.053517 (rank : 220)
Query Neighborhood Hits	249	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

EFS_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.061285 (rank : 194)
Query Neighborhood Hits	249	Target Neighborhood Hits	389	Shared Neighborhood Hits	24
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

FNBP2_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.052741 (rank : 227)
Query Neighborhood Hits	249	Target Neighborhood Hits	432	Shared Neighborhood Hits	28
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FRMD5_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.051946 (rank : 237)
Query Neighborhood Hits	249	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

FRMD5_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.052296 (rank : 230)
Query Neighborhood Hits	249	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

GRAP2_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.076073 (rank : 148)
Query Neighborhood Hits	249	Target Neighborhood Hits	304	Shared Neighborhood Hits	21
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.075385 (rank : 149)
Query Neighborhood Hits	249	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.094563 (rank : 130)
Query Neighborhood Hits	249	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.092442 (rank : 132)
Query Neighborhood Hits	249	Target Neighborhood Hits	309	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.082804 (rank : 143)
Query Neighborhood Hits	249	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.082763 (rank : 144)
Query Neighborhood Hits	249	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.072654 (rank : 160)
Query Neighborhood Hits	249	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.074323 (rank : 156)
Query Neighborhood Hits	249	Target Neighborhood Hits	358	Shared Neighborhood Hits	28
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.075152 (rank : 152)
Query Neighborhood Hits	249	Target Neighborhood Hits	329	Shared Neighborhood Hits	25
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.056112 (rank : 212)
Query Neighborhood Hits	249	Target Neighborhood Hits	1024	Shared Neighborhood Hits	63
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LASP1_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.054849 (rank : 215)
Query Neighborhood Hits	249	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.053080 (rank : 224)
Query Neighborhood Hits	249	Target Neighborhood Hits	297	Shared Neighborhood Hits	21
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

MELPH_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.051139 (rank : 245)
Query Neighborhood Hits	249	Target Neighborhood Hits	145	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

MYRIP_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.056729 (rank : 209)
Query Neighborhood Hits	249	Target Neighborhood Hits	207	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

NCF1_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.119336 (rank : 116)
Query Neighborhood Hits	249	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.111237 (rank : 119)
Query Neighborhood Hits	249	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.100332 (rank : 126)
Query Neighborhood Hits	249	Target Neighborhood Hits	229	Shared Neighborhood Hits	24
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.087659 (rank : 135)
Query Neighborhood Hits	249	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.087603 (rank : 136)
Query Neighborhood Hits	249	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.093496 (rank : 131)
Query Neighborhood Hits	249	Target Neighborhood Hits	312	Shared Neighborhood Hits	25
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.090031 (rank : 133)
Query Neighborhood Hits	249	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBL_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.062340 (rank : 192)
Query Neighborhood Hits	249	Target Neighborhood Hits	457	Shared Neighborhood Hits	27
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.054455 (rank : 217)
Query Neighborhood Hits	249	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.056767 (rank : 208)
Query Neighborhood Hits	249	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.051502 (rank : 239)
Query Neighborhood Hits	249	Target Neighborhood Hits	288	Shared Neighborhood Hits	22
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.062609 (rank : 191)
Query Neighborhood Hits	249	Target Neighborhood Hits	267	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSBL9_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.057975 (rank : 202)
Query Neighborhood Hits	249	Target Neighborhood Hits	138	Shared Neighborhood Hits	23
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSTF1_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.060417 (rank : 198)
Query Neighborhood Hits	249	Target Neighborhood Hits	466	Shared Neighborhood Hits	23
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.059630 (rank : 200)
Query Neighborhood Hits	249	Target Neighborhood Hits	467	Shared Neighborhood Hits	23
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN2_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.052261 (rank : 231)
Query Neighborhood Hits	249	Target Neighborhood Hits	339	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.052455 (rank : 229)
Query Neighborhood Hits	249	Target Neighborhood Hits	382	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_MOUSE
θ value	θ > 10 (rank : 326)	NC score	0.050216 (rank : 251)
Query Neighborhood Hits	249	Target Neighborhood Hits	380	Shared Neighborhood Hits	26
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.052077 (rank : 234)
Query Neighborhood Hits	249	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PKHA4_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.081958 (rank : 145)
Query Neighborhood Hits	249	Target Neighborhood Hits	283	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.080860 (rank : 146)
Query Neighborhood Hits	249	Target Neighborhood Hits	202	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA5_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.084892 (rank : 139)
Query Neighborhood Hits	249	Target Neighborhood Hits	455	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

PKHA6_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.143812 (rank : 114)
Query Neighborhood Hits	249	Target Neighborhood Hits	556	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.139434 (rank : 115)
Query Neighborhood Hits	249	Target Neighborhood Hits	591	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLCG1_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.068461 (rank : 173)
Query Neighborhood Hits	249	Target Neighborhood Hits	293	Shared Neighborhood Hits	19
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.070012 (rank : 167)
Query Neighborhood Hits	249	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.057098 (rank : 206)
Query Neighborhood Hits	249	Target Neighborhood Hits	280	Shared Neighborhood Hits	15
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.073760 (rank : 158)
Query Neighborhood Hits	249	Target Neighborhood Hits	389	Shared Neighborhood Hits	24
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.072175 (rank : 162)
Query Neighborhood Hits	249	Target Neighborhood Hits	377	Shared Neighborhood Hits	29
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

RGL1_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.052158 (rank : 232)
Query Neighborhood Hits	249	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGL1_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.050022 (rank : 253)
Query Neighborhood Hits	249	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

RGNEF_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.407387 (rank : 75)
Query Neighborhood Hits	249	Target Neighborhood Hits	641	Shared Neighborhood Hits	75
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

RHG04_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.060601 (rank : 196)
Query Neighborhood Hits	249	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 342)	NC score	0.050564 (rank : 249)
Query Neighborhood Hits	249	Target Neighborhood Hits	1479	Shared Neighborhood Hits	72
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RPGF1_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.063179 (rank : 190)
Query Neighborhood Hits	249	Target Neighborhood Hits	262	Shared Neighborhood Hits	18
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

RUFY3_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.063503 (rank : 189)
Query Neighborhood Hits	249	Target Neighborhood Hits	594	Shared Neighborhood Hits	19
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.064106 (rank : 188)
Query Neighborhood Hits	249	Target Neighborhood Hits	579	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

SH3G1_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.068882 (rank : 171)
Query Neighborhood Hits	249	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.065497 (rank : 184)
Query Neighborhood Hits	249	Target Neighborhood Hits	291	Shared Neighborhood Hits	21
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.069305 (rank : 170)
Query Neighborhood Hits	249	Target Neighborhood Hits	324	Shared Neighborhood Hits	27
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.066589 (rank : 178)
Query Neighborhood Hits	249	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.068432 (rank : 174)
Query Neighborhood Hits	249	Target Neighborhood Hits	222	Shared Neighborhood Hits	20
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.069416 (rank : 169)
Query Neighborhood Hits	249	Target Neighborhood Hits	236	Shared Neighborhood Hits	20
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.116155 (rank : 118)
Query Neighborhood Hits	249	Target Neighborhood Hits	341	Shared Neighborhood Hits	30
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.107401 (rank : 122)
Query Neighborhood Hits	249	Target Neighborhood Hits	332	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.064781 (rank : 185)
Query Neighborhood Hits	249	Target Neighborhood Hits	446	Shared Neighborhood Hits	34
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPTA1_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.056790 (rank : 207)
Query Neighborhood Hits	249	Target Neighborhood Hits	748	Shared Neighborhood Hits	39
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	θ > 10 (rank : 356)	NC score	0.057896 (rank : 203)
Query Neighborhood Hits	249	Target Neighborhood Hits	675	Shared Neighborhood Hits	34
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
θ value	θ > 10 (rank : 357)	NC score	0.061864 (rank : 193)
Query Neighborhood Hits	249	Target Neighborhood Hits	888	Shared Neighborhood Hits	37
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SRBS1_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.101704 (rank : 125)
Query Neighborhood Hits	249	Target Neighborhood Hits	396	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.103422 (rank : 124)
Query Neighborhood Hits	249	Target Neighborhood Hits	409	Shared Neighborhood Hits	32
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.075204 (rank : 150)
Query Neighborhood Hits	249	Target Neighborhood Hits	269	Shared Neighborhood Hits	25
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.074135 (rank : 157)
Query Neighborhood Hits	249	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRGP1_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.051322 (rank : 242)
Query Neighborhood Hits	249	Target Neighborhood Hits	390	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

STAC3_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.074680 (rank : 153)
Query Neighborhood Hits	249	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 364)	NC score	0.075160 (rank : 151)
Query Neighborhood Hits	249	Target Neighborhood Hits	232	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.086403 (rank : 138)
Query Neighborhood Hits	249	Target Neighborhood Hits	276	Shared Neighborhood Hits	23
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.083458 (rank : 142)
Query Neighborhood Hits	249	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.088346 (rank : 134)
Query Neighborhood Hits	249	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.087474 (rank : 137)
Query Neighborhood Hits	249	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.083499 (rank : 141)
Query Neighborhood Hits	249	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 370)	NC score	0.083703 (rank : 140)
Query Neighborhood Hits	249	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SWP70_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.076514 (rank : 147)
Query Neighborhood Hits	249	Target Neighborhood Hits	973	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

TCGAP_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.069483 (rank : 168)
Query Neighborhood Hits	249	Target Neighborhood Hits	872	Shared Neighborhood Hits	61
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.064495 (rank : 186)
Query Neighborhood Hits	249	Target Neighborhood Hits	409	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

VINEX_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.095686 (rank : 127)
Query Neighborhood Hits	249	Target Neighborhood Hits	270	Shared Neighborhood Hits	26
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 375)	NC score	0.094943 (rank : 128)
Query Neighborhood Hits	249	Target Neighborhood Hits	286	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

Hits sorted by NC score

FGD3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	249	Target Neighborhood Hits	249	Shared Neighborhood Hits	249
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
NC score	0.978640 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	249	Target Neighborhood Hits	257	Shared Neighborhood Hits	148
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD2_HUMAN
NC score	0.958998 (rank : 3)	θ value	2.06368e-129 (rank : 7)
Query Neighborhood Hits	249	Target Neighborhood Hits	151	Shared Neighborhood Hits	115
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD4_HUMAN
NC score	0.957184 (rank : 4)	θ value	2.511e-143 (rank : 6)
Query Neighborhood Hits	249	Target Neighborhood Hits	219	Shared Neighborhood Hits	117
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
NC score	0.956267 (rank : 5)	θ value	5.05951e-144 (rank : 5)
Query Neighborhood Hits	249	Target Neighborhood Hits	227	Shared Neighborhood Hits	117
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD2_MOUSE
NC score	0.954095 (rank : 6)	θ value	7.33985e-127 (rank : 8)
Query Neighborhood Hits	249	Target Neighborhood Hits	163	Shared Neighborhood Hits	112
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD1_HUMAN
NC score	0.947911 (rank : 7)	θ value	5.01279e-176 (rank : 3)
Query Neighborhood Hits	249	Target Neighborhood Hits	367	Shared Neighborhood Hits	130
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
NC score	0.946063 (rank : 8)	θ value	1.78289e-173 (rank : 4)
Query Neighborhood Hits	249	Target Neighborhood Hits	387	Shared Neighborhood Hits	130
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD6_HUMAN
NC score	0.868451 (rank : 9)	θ value	1.08223e-53 (rank : 10)
Query Neighborhood Hits	249	Target Neighborhood Hits	237	Shared Neighborhood Hits	107
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
NC score	0.868323 (rank : 10)	θ value	2.57589e-55 (rank : 9)
Query Neighborhood Hits	249	Target Neighborhood Hits	282	Shared Neighborhood Hits	108
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD5_HUMAN
NC score	0.799008 (rank : 11)	θ value	1.05066e-40 (rank : 11)
Query Neighborhood Hits	249	Target Neighborhood Hits	235	Shared Neighborhood Hits	99
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
NC score	0.792274 (rank : 12)	θ value	8.32485e-38 (rank : 12)
Query Neighborhood Hits	249	Target Neighborhood Hits	170	Shared Neighborhood Hits	96
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PREX1_HUMAN
NC score	0.736814 (rank : 13)	θ value	1.05554e-24 (rank : 16)
Query Neighborhood Hits	249	Target Neighborhood Hits	177	Shared Neighborhood Hits	82
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

ECT2_MOUSE
NC score	0.730840 (rank : 14)	θ value	8.65492e-19 (rank : 18)
Query Neighborhood Hits	249	Target Neighborhood Hits	98	Shared Neighborhood Hits	72
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_HUMAN
NC score	0.717268 (rank : 15)	θ value	1.92812e-18 (rank : 19)
Query Neighborhood Hits	249	Target Neighborhood Hits	98	Shared Neighborhood Hits	71
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

PKHG1_HUMAN
NC score	0.692447 (rank : 16)	θ value	3.40345e-15 (rank : 26)
Query Neighborhood Hits	249	Target Neighborhood Hits	174	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

ARHG4_MOUSE
NC score	0.664942 (rank : 17)	θ value	1.80466e-16 (rank : 21)
Query Neighborhood Hits	249	Target Neighborhood Hits	185	Shared Neighborhood Hits	68
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_HUMAN
NC score	0.650990 (rank : 18)	θ value	1.2077e-20 (rank : 17)
Query Neighborhood Hits	249	Target Neighborhood Hits	242	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
NC score	0.643901 (rank : 19)	θ value	9.26847e-13 (rank : 34)
Query Neighborhood Hits	249	Target Neighborhood Hits	172	Shared Neighborhood Hits	69
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

NGEF_HUMAN
NC score	0.638414 (rank : 20)	θ value	1.99529e-15 (rank : 24)
Query Neighborhood Hits	249	Target Neighborhood Hits	166	Shared Neighborhood Hits	70
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHG9_HUMAN
NC score	0.628600 (rank : 21)	θ value	1.47974e-10 (rank : 48)
Query Neighborhood Hits	249	Target Neighborhood Hits	235	Shared Neighborhood Hits	70
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.627327 (rank : 22)	θ value	3.29651e-10 (rank : 52)
Query Neighborhood Hits	249	Target Neighborhood Hits	234	Shared Neighborhood Hits	70
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

NGEF_MOUSE
NC score	0.625222 (rank : 23)	θ value	1.52774e-15 (rank : 23)
Query Neighborhood Hits	249	Target Neighborhood Hits	228	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

ARHGG_HUMAN
NC score	0.621317 (rank : 24)	θ value	4.0297e-08 (rank : 65)
Query Neighborhood Hits	249	Target Neighborhood Hits	129	Shared Neighborhood Hits	67
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2_HUMAN
NC score	0.610551 (rank : 25)	θ value	2.52405e-10 (rank : 51)
Query Neighborhood Hits	249	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGA_HUMAN
NC score	0.604352 (rank : 26)	θ value	2.98157e-11 (rank : 41)
Query Neighborhood Hits	249	Target Neighborhood Hits	187	Shared Neighborhood Hits	65
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
NC score	0.601130 (rank : 27)	θ value	1.74796e-11 (rank : 39)
Query Neighborhood Hits	249	Target Neighborhood Hits	125	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGG_MOUSE
NC score	0.600470 (rank : 28)	θ value	1.17247e-07 (rank : 72)
Query Neighborhood Hits	249	Target Neighborhood Hits	152	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

MCF2L_MOUSE
NC score	0.578579 (rank : 29)	θ value	4.59992e-12 (rank : 38)
Query Neighborhood Hits	249	Target Neighborhood Hits	255	Shared Neighborhood Hits	70
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

ARHG2_MOUSE
NC score	0.578195 (rank : 30)	θ value	2.69671e-12 (rank : 36)
Query Neighborhood Hits	249	Target Neighborhood Hits	120	Shared Neighborhood Hits	63
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

PKHF2_HUMAN
NC score	0.575385 (rank : 31)	θ value	4.76016e-09 (rank : 59)
Query Neighborhood Hits	249	Target Neighborhood Hits	75	Shared Neighborhood Hits	57
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.574849 (rank : 32)	θ value	1.38499e-08 (rank : 63)
Query Neighborhood Hits	249	Target Neighborhood Hits	77	Shared Neighborhood Hits	57
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

ARHG1_HUMAN
NC score	0.567839 (rank : 33)	θ value	1.47974e-10 (rank : 47)
Query Neighborhood Hits	249	Target Neighborhood Hits	176	Shared Neighborhood Hits	82
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

TIAM1_MOUSE
NC score	0.567255 (rank : 34)	θ value	8.97725e-08 (rank : 69)
Query Neighborhood Hits	249	Target Neighborhood Hits	205	Shared Neighborhood Hits	72
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

FARP2_MOUSE
NC score	0.566456 (rank : 35)	θ value	1.6813e-30 (rank : 13)
Query Neighborhood Hits	249	Target Neighborhood Hits	209	Shared Neighborhood Hits	76
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

TIAM1_HUMAN
NC score	0.563727 (rank : 36)	θ value	3.77169e-06 (rank : 80)
Query Neighborhood Hits	249	Target Neighborhood Hits	225	Shared Neighborhood Hits	71
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PKHF1_HUMAN
NC score	0.560005 (rank : 37)	θ value	1.69304e-06 (rank : 78)
Query Neighborhood Hits	249	Target Neighborhood Hits	76	Shared Neighborhood Hits	61
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
NC score	0.556525 (rank : 38)	θ value	1.69304e-06 (rank : 79)
Query Neighborhood Hits	249	Target Neighborhood Hits	80	Shared Neighborhood Hits	59
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

ARHG3_MOUSE
NC score	0.554993 (rank : 39)	θ value	1.17247e-07 (rank : 71)
Query Neighborhood Hits	249	Target Neighborhood Hits	85	Shared Neighborhood Hits	64
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG3_HUMAN
NC score	0.553964 (rank : 40)	θ value	1.17247e-07 (rank : 70)
Query Neighborhood Hits	249	Target Neighborhood Hits	82	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG8_HUMAN
NC score	0.545677 (rank : 41)	θ value	9.29e-05 (rank : 89)
Query Neighborhood Hits	249	Target Neighborhood Hits	85	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

FARP2_HUMAN
NC score	0.545492 (rank : 42)	θ value	1.47289e-26 (rank : 14)
Query Neighborhood Hits	249	Target Neighborhood Hits	240	Shared Neighborhood Hits	74
SwissProt Accessions	O94887, Q53QM5, Q8WU27, Q9UFE7	Gene names	FARP2, KIAA0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

ARHG1_MOUSE
NC score	0.545154 (rank : 43)	θ value	2.13673e-09 (rank : 58)
Query Neighborhood Hits	249	Target Neighborhood Hits	266	Shared Neighborhood Hits	81
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHGF_HUMAN
NC score	0.543980 (rank : 44)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	249	Target Neighborhood Hits	214	Shared Neighborhood Hits	67
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

LBC_HUMAN
NC score	0.542542 (rank : 45)	θ value	1.9326e-10 (rank : 49)
Query Neighborhood Hits	249	Target Neighborhood Hits	90	Shared Neighborhood Hits	57
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

HAPIP_HUMAN
NC score	0.537752 (rank : 46)	θ value	6.41864e-14 (rank : 30)
Query Neighborhood Hits	249	Target Neighborhood Hits	350	Shared Neighborhood Hits	78
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ARHGB_HUMAN
NC score	0.537140 (rank : 47)	θ value	3.89403e-11 (rank : 43)
Query Neighborhood Hits	249	Target Neighborhood Hits	375	Shared Neighborhood Hits	72
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHG2_HUMAN
NC score	0.530790 (rank : 48)	θ value	9.26847e-13 (rank : 33)
Query Neighborhood Hits	249	Target Neighborhood Hits	142	Shared Neighborhood Hits	63
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

PKHG4_HUMAN
NC score	0.519556 (rank : 49)	θ value	8.97725e-08 (rank : 67)
Query Neighborhood Hits	249	Target Neighborhood Hits	200	Shared Neighborhood Hits	69
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

FARP1_HUMAN
NC score	0.515031 (rank : 50)	θ value	3.28125e-26 (rank : 15)
Query Neighborhood Hits	249	Target Neighborhood Hits	241	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

GNRP_MOUSE
NC score	0.511716 (rank : 51)	θ value	2.98157e-11 (rank : 42)
Query Neighborhood Hits	249	Target Neighborhood Hits	191	Shared Neighborhood Hits	61
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

ARHGC_HUMAN
NC score	0.511194 (rank : 52)	θ value	9.59137e-10 (rank : 54)
Query Neighborhood Hits	249	Target Neighborhood Hits	351	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
NC score	0.510523 (rank : 53)	θ value	8.67504e-11 (rank : 45)
Query Neighborhood Hits	249	Target Neighborhood Hits	344	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GNRP_HUMAN
NC score	0.480701 (rank : 54)	θ value	2.28291e-11 (rank : 40)
Query Neighborhood Hits	249	Target Neighborhood Hits	239	Shared Neighborhood Hits	60
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

ARHG8_MOUSE
NC score	0.476597 (rank : 55)	θ value	0.000602161 (rank : 100)
Query Neighborhood Hits	249	Target Neighborhood Hits	79	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

VAV_MOUSE
NC score	0.472018 (rank : 56)	θ value	6.64225e-11 (rank : 44)
Query Neighborhood Hits	249	Target Neighborhood Hits	430	Shared Neighborhood Hits	69
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV2_MOUSE
NC score	0.470883 (rank : 57)	θ value	4.91457e-14 (rank : 29)
Query Neighborhood Hits	249	Target Neighborhood Hits	456	Shared Neighborhood Hits	78
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ARHG7_HUMAN
NC score	0.469293 (rank : 58)	θ value	1.06045e-08 (rank : 62)
Query Neighborhood Hits	249	Target Neighborhood Hits	347	Shared Neighborhood Hits	74
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

VAV_HUMAN
NC score	0.463633 (rank : 59)	θ value	1.133e-10 (rank : 46)
Query Neighborhood Hits	249	Target Neighborhood Hits	452	Shared Neighborhood Hits	70
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV2_HUMAN
NC score	0.461909 (rank : 60)	θ value	1.42992e-13 (rank : 31)
Query Neighborhood Hits	249	Target Neighborhood Hits	453	Shared Neighborhood Hits	74
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV3_MOUSE
NC score	0.458394 (rank : 61)	θ value	2.69671e-12 (rank : 37)
Query Neighborhood Hits	249	Target Neighborhood Hits	404	Shared Neighborhood Hits	70
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV3_HUMAN
NC score	0.455978 (rank : 62)	θ value	2.0648e-12 (rank : 35)
Query Neighborhood Hits	249	Target Neighborhood Hits	398	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

ZFY28_HUMAN
NC score	0.454668 (rank : 63)	θ value	0.000461057 (rank : 98)
Query Neighborhood Hits	249	Target Neighborhood Hits	152	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ARHG7_MOUSE
NC score	0.451900 (rank : 64)	θ value	8.11959e-09 (rank : 60)
Query Neighborhood Hits	249	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DNMBP_MOUSE
NC score	0.450104 (rank : 65)	θ value	3.08544e-08 (rank : 64)
Query Neighborhood Hits	249	Target Neighborhood Hits	435	Shared Neighborhood Hits	70
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ZFYV9_HUMAN
NC score	0.439806 (rank : 66)	θ value	1.09739e-05 (rank : 83)
Query Neighborhood Hits	249	Target Neighborhood Hits	134	Shared Neighborhood Hits	56
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

ZFY21_MOUSE
NC score	0.436807 (rank : 67)	θ value	0.000270298 (rank : 95)
Query Neighborhood Hits	249	Target Neighborhood Hits	72	Shared Neighborhood Hits	56
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

DNMBP_HUMAN
NC score	0.431767 (rank : 68)	θ value	6.87365e-08 (rank : 66)
Query Neighborhood Hits	249	Target Neighborhood Hits	413	Shared Neighborhood Hits	72
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ZFY16_MOUSE
NC score	0.429793 (rank : 69)	θ value	3.77169e-06 (rank : 81)
Query Neighborhood Hits	249	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY21_HUMAN
NC score	0.428783 (rank : 70)	θ value	0.000786445 (rank : 102)
Query Neighborhood Hits	249	Target Neighborhood Hits	72	Shared Neighborhood Hits	56
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ABR_HUMAN
NC score	0.423757 (rank : 71)	θ value	5.62301e-10 (rank : 53)
Query Neighborhood Hits	249	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

ITSN2_HUMAN
NC score	0.423086 (rank : 72)	θ value	4.91457e-14 (rank : 28)
Query Neighborhood Hits	249	Target Neighborhood Hits	1173	Shared Neighborhood Hits	87
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ZFY16_HUMAN
NC score	0.422982 (rank : 73)	θ value	5.81887e-07 (rank : 77)
Query Neighborhood Hits	249	Target Neighborhood Hits	125	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

BCR_HUMAN
NC score	0.422045 (rank : 74)	θ value	1.63604e-09 (rank : 57)
Query Neighborhood Hits	249	Target Neighborhood Hits	204	Shared Neighborhood Hits	62
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

RGNEF_MOUSE
NC score	0.407387 (rank : 75)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	249	Target Neighborhood Hits	641	Shared Neighborhood Hits	75
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

ITSN2_MOUSE
NC score	0.400894 (rank : 76)	θ value	3.18553e-13 (rank : 32)
Query Neighborhood Hits	249	Target Neighborhood Hits	1371	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ITSN1_HUMAN
NC score	0.394794 (rank : 77)	θ value	7.58209e-15 (rank : 27)
Query Neighborhood Hits	249	Target Neighborhood Hits	1757	Shared Neighborhood Hits	105
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.393891 (rank : 78)	θ value	3.40345e-15 (rank : 25)
Query Neighborhood Hits	249	Target Neighborhood Hits	1669	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ARHG6_HUMAN
NC score	0.384922 (rank : 79)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	249	Target Neighborhood Hits	376	Shared Neighborhood Hits	62
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
NC score	0.347868 (rank : 80)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	249	Target Neighborhood Hits	394	Shared Neighborhood Hits	63
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

RBNS5_HUMAN
NC score	0.344027 (rank : 81)	θ value	2.44474e-05 (rank : 87)
Query Neighborhood Hits	249	Target Neighborhood Hits	242	Shared Neighborhood Hits	54
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

HGS_MOUSE
NC score	0.340204 (rank : 82)	θ value	2.44474e-05 (rank : 86)
Query Neighborhood Hits	249	Target Neighborhood Hits	589	Shared Neighborhood Hits	64
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HGS_HUMAN
NC score	0.340079 (rank : 83)	θ value	2.44474e-05 (rank : 85)
Query Neighborhood Hits	249	Target Neighborhood Hits	517	Shared Neighborhood Hits	63
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

RBNS5_MOUSE
NC score	0.339802 (rank : 84)	θ value	2.44474e-05 (rank : 88)
Query Neighborhood Hits	249	Target Neighborhood Hits	266	Shared Neighborhood Hits	56
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

SOS2_HUMAN
NC score	0.331228 (rank : 85)	θ value	1.25267e-09 (rank : 56)
Query Neighborhood Hits	249	Target Neighborhood Hits	193	Shared Neighborhood Hits	40
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

SOS1_HUMAN
NC score	0.327049 (rank : 86)	θ value	1.17247e-07 (rank : 73)
Query Neighborhood Hits	249	Target Neighborhood Hits	274	Shared Neighborhood Hits	40
SwissProt Accessions	Q07889	Gene names	SOS1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1).

ZFYV1_HUMAN
NC score	0.310819 (rank : 87)	θ value	0.0563607 (rank : 110)
Query Neighborhood Hits	249	Target Neighborhood Hits	166	Shared Neighborhood Hits	56
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

SOS1_MOUSE
NC score	0.307848 (rank : 88)	θ value	5.81887e-07 (rank : 76)
Query Neighborhood Hits	249	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	Q62245, Q62244	Gene names	Sos1
Domain Architecture
Description	Son of sevenless homolog 1 (SOS-1) (mSOS-1).

ZFYV1_MOUSE
NC score	0.307665 (rank : 89)	θ value	0.0563607 (rank : 111)
Query Neighborhood Hits	249	Target Neighborhood Hits	153	Shared Neighborhood Hits	60
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ZFY19_HUMAN
NC score	0.295836 (rank : 90)	θ value	0.163984 (rank : 125)
Query Neighborhood Hits	249	Target Neighborhood Hits	206	Shared Neighborhood Hits	59
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

FYV1_HUMAN
NC score	0.289472 (rank : 91)	θ value	0.000121331 (rank : 91)
Query Neighborhood Hits	249	Target Neighborhood Hits	217	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

ZFY19_MOUSE
NC score	0.289353 (rank : 92)	θ value	0.163984 (rank : 126)
Query Neighborhood Hits	249	Target Neighborhood Hits	143	Shared Neighborhood Hits	55
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

FYV1_MOUSE
NC score	0.286175 (rank : 93)	θ value	0.000602161 (rank : 101)
Query Neighborhood Hits	249	Target Neighborhood Hits	191	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

WDFY3_MOUSE
NC score	0.260137 (rank : 94)	θ value	1.17247e-07 (rank : 75)
Query Neighborhood Hits	249	Target Neighborhood Hits	332	Shared Neighborhood Hits	56
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

WDFY3_HUMAN
NC score	0.259990 (rank : 95)	θ value	1.17247e-07 (rank : 74)
Query Neighborhood Hits	249	Target Neighborhood Hits	348	Shared Neighborhood Hits	56
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY1_HUMAN
NC score	0.255854 (rank : 96)	θ value	0.000461057 (rank : 97)
Query Neighborhood Hits	249	Target Neighborhood Hits	305	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

RUFY2_MOUSE
NC score	0.250287 (rank : 97)	θ value	1.43324e-05 (rank : 84)
Query Neighborhood Hits	249	Target Neighborhood Hits	820	Shared Neighborhood Hits	64
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

RUFY1_MOUSE
NC score	0.247896 (rank : 98)	θ value	0.000121331 (rank : 92)
Query Neighborhood Hits	249	Target Neighborhood Hits	765	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY1_HUMAN
NC score	0.242950 (rank : 99)	θ value	0.000270298 (rank : 94)
Query Neighborhood Hits	249	Target Neighborhood Hits	848	Shared Neighborhood Hits	72
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

WDFY2_MOUSE
NC score	0.234932 (rank : 100)	θ value	0.00134147 (rank : 104)
Query Neighborhood Hits	249	Target Neighborhood Hits	337	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

MTMR3_HUMAN
NC score	0.233540 (rank : 101)	θ value	0.000158464 (rank : 93)
Query Neighborhood Hits	249	Target Neighborhood Hits	163	Shared Neighborhood Hits	55
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

WDFY2_HUMAN
NC score	0.233259 (rank : 102)	θ value	0.00134147 (rank : 103)
Query Neighborhood Hits	249	Target Neighborhood Hits	332	Shared Neighborhood Hits	51
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

DUET_HUMAN
NC score	0.228737 (rank : 103)	θ value	2.5182e-18 (rank : 20)
Query Neighborhood Hits	249	Target Neighborhood Hits	1220	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y2A5, Q8TBQ5, Q9NSZ4	Gene names	DUET, TRAD
Domain Architecture
Description	Serine/threonine-protein kinase Duet (EC 2.7.11.1) (Serine/threonine kinase with Dbl- and pleckstrin homology domain).

TRIO_HUMAN
NC score	0.219799 (rank : 104)	θ value	6.85773e-16 (rank : 22)
Query Neighborhood Hits	249	Target Neighborhood Hits	1580	Shared Neighborhood Hits	92
SwissProt Accessions	O75962, Q13458	Gene names	TRIO
Domain Architecture
Description	Triple functional domain protein (PTPRF-interacting protein).

RUFY2_HUMAN
NC score	0.209522 (rank : 105)	θ value	8.97725e-08 (rank : 68)
Query Neighborhood Hits	249	Target Neighborhood Hits	1208	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

ZFY27_MOUSE
NC score	0.198470 (rank : 106)	θ value	0.0736092 (rank : 116)
Query Neighborhood Hits	249	Target Neighborhood Hits	53	Shared Neighborhood Hits	45
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_HUMAN
NC score	0.190999 (rank : 107)	θ value	0.0736092 (rank : 115)
Query Neighborhood Hits	249	Target Neighborhood Hits	64	Shared Neighborhood Hits	44
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

FYCO1_HUMAN
NC score	0.174061 (rank : 108)	θ value	8.40245e-06 (rank : 82)
Query Neighborhood Hits	249	Target Neighborhood Hits	1149	Shared Neighborhood Hits	71
SwissProt Accessions	Q9BQS8, Q3MJE6, Q86T41, Q86TB1, Q8TEF9, Q96IV5, Q9H8P9	Gene names	FYCO1, ZFYVE7
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1 (Zinc finger FYVE domain-containing protein 7).

EEA1_MOUSE
NC score	0.173759 (rank : 109)	θ value	1.25267e-09 (rank : 55)
Query Neighborhood Hits	249	Target Neighborhood Hits	1637	Shared Neighborhood Hits	85
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

FYCO1_MOUSE
NC score	0.162485 (rank : 110)	θ value	9.29e-05 (rank : 90)
Query Neighborhood Hits	249	Target Neighborhood Hits	1059	Shared Neighborhood Hits	72
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

EEA1_HUMAN
NC score	0.161599 (rank : 111)	θ value	8.11959e-09 (rank : 61)
Query Neighborhood Hits	249	Target Neighborhood Hits	1796	Shared Neighborhood Hits	86
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

ANFY1_MOUSE
NC score	0.161248 (rank : 112)	θ value	0.000461057 (rank : 96)
Query Neighborhood Hits	249	Target Neighborhood Hits	480	Shared Neighborhood Hits	58
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.160854 (rank : 113)	θ value	0.000602161 (rank : 99)
Query Neighborhood Hits	249	Target Neighborhood Hits	480	Shared Neighborhood Hits	56
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

PKHA6_HUMAN
NC score	0.143812 (rank : 114)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	249	Target Neighborhood Hits	556	Shared Neighborhood Hits	55
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.139434 (rank : 115)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	249	Target Neighborhood Hits	591	Shared Neighborhood Hits	50
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

NCF1_HUMAN
NC score	0.119336 (rank : 116)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	249	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ALS2_MOUSE
NC score	0.116375 (rank : 117)	θ value	0.125558 (rank : 117)
Query Neighborhood Hits	249	Target Neighborhood Hits	111	Shared Neighborhood Hits	20
SwissProt Accessions	Q920R0, Q8JZR1, Q9CXJ3	Gene names	Als2
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2 homolog).

SH3K1_HUMAN
NC score	0.116155 (rank : 118)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	249	Target Neighborhood Hits	341	Shared Neighborhood Hits	30
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

NCF1_MOUSE
NC score	0.111237 (rank : 119)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	249	Target Neighborhood Hits	198	Shared Neighborhood Hits	24
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

OBSCN_HUMAN
NC score	0.109240 (rank : 120)	θ value	1.9326e-10 (rank : 50)
Query Neighborhood Hits	249	Target Neighborhood Hits	1931	Shared Neighborhood Hits	88
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

CD2AP_HUMAN
NC score	0.107551 (rank : 121)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	249	Target Neighborhood Hits	315	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_MOUSE
NC score	0.107401 (rank : 122)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	249	Target Neighborhood Hits	332	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CD2AP_MOUSE
NC score	0.106082 (rank : 123)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	249	Target Neighborhood Hits	336	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

SRBS1_MOUSE
NC score	0.103422 (rank : 124)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	249	Target Neighborhood Hits	409	Shared Neighborhood Hits	32
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.101704 (rank : 125)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	249	Target Neighborhood Hits	396	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

NCF2_HUMAN
NC score	0.100332 (rank : 126)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	249	Target Neighborhood Hits	229	Shared Neighborhood Hits	24
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

VINEX_HUMAN
NC score	0.095686 (rank : 127)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	249	Target Neighborhood Hits	270	Shared Neighborhood Hits	26
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.094943 (rank : 128)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	249	Target Neighborhood Hits	286	Shared Neighborhood Hits	25
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ALS2_HUMAN
NC score	0.094819 (rank : 129)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	249	Target Neighborhood Hits	121	Shared Neighborhood Hits	20
SwissProt Accessions	Q96Q42, Q8N1E0, Q96PC4, Q96Q41, Q9H973, Q9HCK9	Gene names	ALS2, KIAA1563
Domain Architecture
Description	Alsin (Amyotrophic lateral sclerosis protein 2).

GRAP_HUMAN
NC score	0.094563 (rank : 130)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	249	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCK1_HUMAN
NC score	0.093496 (rank : 131)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	249	Target Neighborhood Hits	312	Shared Neighborhood Hits	25
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

GRAP_MOUSE
NC score	0.092442 (rank : 132)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	249	Target Neighborhood Hits	309	Shared Neighborhood Hits	23
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

NCK2_HUMAN
NC score	0.090031 (rank : 133)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	249	Target Neighborhood Hits	310	Shared Neighborhood Hits	25
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

STAM1_HUMAN
NC score	0.088346 (rank : 134)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	249	Target Neighborhood Hits	271	Shared Neighborhood Hits	24
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF4_HUMAN
NC score	0.087659 (rank : 135)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	249	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
NC score	0.087603 (rank : 136)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	249	Target Neighborhood Hits	177	Shared Neighborhood Hits	19
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAM1_MOUSE
NC score	0.087474 (rank : 137)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	249	Target Neighborhood Hits	273	Shared Neighborhood Hits	23
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAC_HUMAN
NC score	0.086403 (rank : 138)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	249	Target Neighborhood Hits	276	Shared Neighborhood Hits	23
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

PKHA5_HUMAN
NC score	0.084892 (rank : 139)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	249	Target Neighborhood Hits	455	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

STAM2_MOUSE
NC score	0.083703 (rank : 140)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	249	Target Neighborhood Hits	285	Shared Neighborhood Hits	26
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STAM2_HUMAN
NC score	0.083499 (rank : 141)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	249	Target Neighborhood Hits	288	Shared Neighborhood Hits	25
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAC_MOUSE
NC score	0.083458 (rank : 142)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	249	Target Neighborhood Hits	268	Shared Neighborhood Hits	23
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRB2_HUMAN
NC score	0.082804 (rank : 143)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	249	Target Neighborhood Hits	310	Shared Neighborhood Hits	20
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.082763 (rank : 144)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	249	Target Neighborhood Hits	312	Shared Neighborhood Hits	20
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

PKHA4_HUMAN
NC score	0.081958 (rank : 145)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	249	Target Neighborhood Hits	283	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
NC score	0.080860 (rank : 146)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	249	Target Neighborhood Hits	202	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SWP70_HUMAN
NC score	0.076514 (rank : 147)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	249	Target Neighborhood Hits	973	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

GRAP2_HUMAN
NC score	0.076073 (rank : 148)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	249	Target Neighborhood Hits	304	Shared Neighborhood Hits	21
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
NC score	0.075385 (rank : 149)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	249	Target Neighborhood Hits	297	Shared Neighborhood Hits	20
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SRC8_HUMAN
NC score	0.075204 (rank : 150)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	249	Target Neighborhood Hits	269	Shared Neighborhood Hits	25
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAC3_MOUSE
NC score	0.075160 (rank : 151)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	249	Target Neighborhood Hits	232	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

HCLS1_MOUSE
NC score	0.075152 (rank : 152)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	249	Target Neighborhood Hits	329	Shared Neighborhood Hits	25
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

STAC3_HUMAN
NC score	0.074680 (rank : 153)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	249	Target Neighborhood Hits	228	Shared Neighborhood Hits	21
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SWP70_MOUSE
NC score	0.074622 (rank : 154)	θ value	8.99809 (rank : 246)
Query Neighborhood Hits	249	Target Neighborhood Hits	1097	Shared Neighborhood Hits	49
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ABI2_HUMAN
NC score	0.074348 (rank : 155)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	249	Target Neighborhood Hits	350	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

HCLS1_HUMAN
NC score	0.074323 (rank : 156)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	249	Target Neighborhood Hits	358	Shared Neighborhood Hits	28
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SRC8_MOUSE
NC score	0.074135 (rank : 157)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	249	Target Neighborhood Hits	292	Shared Neighborhood Hits	27
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

PPIP1_HUMAN
NC score	0.073760 (rank : 158)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	249	Target Neighborhood Hits	389	Shared Neighborhood Hits	24
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

CRKL_HUMAN
NC score	0.073372 (rank : 159)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	249	Target Neighborhood Hits	313	Shared Neighborhood Hits	20
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GRP3_HUMAN
NC score	0.072654 (rank : 160)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	249	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

ABI2_MOUSE
NC score	0.072577 (rank : 161)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	249	Target Neighborhood Hits	266	Shared Neighborhood Hits	23
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

PPIP1_MOUSE
NC score	0.072175 (rank : 162)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	249	Target Neighborhood Hits	377	Shared Neighborhood Hits	29
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

BI2L1_HUMAN
NC score	0.071421 (rank : 163)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	249	Target Neighborhood Hits	156	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

CRKL_MOUSE
NC score	0.071401 (rank : 164)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	249	Target Neighborhood Hits	307	Shared Neighborhood Hits	19
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRK_MOUSE
NC score	0.070856 (rank : 165)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	249	Target Neighborhood Hits	314	Shared Neighborhood Hits	21
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ABI1_MOUSE
NC score	0.070590 (rank : 166)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	249	Target Neighborhood Hits	246	Shared Neighborhood Hits	24
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PLCG1_MOUSE
NC score	0.070012 (rank : 167)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	249	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

TCGAP_HUMAN
NC score	0.069483 (rank : 168)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	249	Target Neighborhood Hits	872	Shared Neighborhood Hits	61
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

SH3G3_MOUSE
NC score	0.069416 (rank : 169)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	249	Target Neighborhood Hits	236	Shared Neighborhood Hits	20
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G2_HUMAN
NC score	0.069305 (rank : 170)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	249	Target Neighborhood Hits	324	Shared Neighborhood Hits	27
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G1_HUMAN
NC score	0.068882 (rank : 171)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	249	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

RNF34_MOUSE
NC score	0.068507 (rank : 172)	θ value	0.47712 (rank : 139)
Query Neighborhood Hits	249	Target Neighborhood Hits	160	Shared Neighborhood Hits	36
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

PLCG1_HUMAN
NC score	0.068461 (rank : 173)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	249	Target Neighborhood Hits	293	Shared Neighborhood Hits	19
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G3_HUMAN
NC score	0.068432 (rank : 174)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	249	Target Neighborhood Hits	222	Shared Neighborhood Hits	20
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

CRK_HUMAN
NC score	0.067397 (rank : 175)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	249	Target Neighborhood Hits	308	Shared Neighborhood Hits	20
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

MELPH_MOUSE
NC score	0.066777 (rank : 176)	θ value	1.81305 (rank : 167)
Query Neighborhood Hits	249	Target Neighborhood Hits	112	Shared Neighborhood Hits	16
SwissProt Accessions	Q91V27, Q99N53	Gene names	Mlph, Ln, Slac2a
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Leaden protein) (Synaptotagmin-like protein 2a) (Slac2-a) (Slp homolog lacking C2 domains a).

RFFL_MOUSE
NC score	0.066772 (rank : 177)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	249	Target Neighborhood Hits	145	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

SH3G2_MOUSE
NC score	0.066589 (rank : 178)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	249	Target Neighborhood Hits	319	Shared Neighborhood Hits	27
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

AHI1_HUMAN
NC score	0.066440 (rank : 179)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	249	Target Neighborhood Hits	537	Shared Neighborhood Hits	32
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

DGKH_HUMAN
NC score	0.065941 (rank : 180)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	249	Target Neighborhood Hits	255	Shared Neighborhood Hits	29
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

RNF34_HUMAN
NC score	0.065807 (rank : 181)	θ value	0.365318 (rank : 137)
Query Neighborhood Hits	249	Target Neighborhood Hits	153	Shared Neighborhood Hits	34
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

ABI1_HUMAN
NC score	0.065585 (rank : 182)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	249	Target Neighborhood Hits	257	Shared Neighborhood Hits	24
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI3_HUMAN
NC score	0.065518 (rank : 183)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	249	Target Neighborhood Hits	227	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SH3G1_MOUSE
NC score	0.065497 (rank : 184)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	249	Target Neighborhood Hits	291	Shared Neighborhood Hits	21
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SHAN2_MOUSE
NC score	0.064781 (rank : 185)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	249	Target Neighborhood Hits	446	Shared Neighborhood Hits	34
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TCGAP_MOUSE
NC score	0.064495 (rank : 186)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	249	Target Neighborhood Hits	409	Shared Neighborhood Hits	42
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ABI3_MOUSE
NC score	0.064490 (rank : 187)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	249	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

RUFY3_MOUSE
NC score	0.064106 (rank : 188)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	249	Target Neighborhood Hits	579	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D394, Q3U348, Q3UF96, Q6PE64, Q8VD10	Gene names	Rufy3, D5Bwg0860e, Ripx
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RUFY3_HUMAN
NC score	0.063503 (rank : 189)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	249	Target Neighborhood Hits	594	Shared Neighborhood Hits	19
SwissProt Accessions	Q7L099, O94948, Q9UI00	Gene names	RUFY3, KIAA0871
Domain Architecture	No domain graphic available
Description	Protein RUFY3 (Rap2-interacting protein x) (RIPx).

RPGF1_HUMAN
NC score	0.063179 (rank : 190)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	249	Target Neighborhood Hits	262	Shared Neighborhood Hits	18
SwissProt Accessions	Q13905	Gene names	RAPGEF1, GRF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 1 (Guanine nucleotide-releasing factor 2) (C3G protein) (CRK SH3-binding GNRP).

NPHP1_MOUSE
NC score	0.062609 (rank : 191)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	249	Target Neighborhood Hits	267	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NEBL_HUMAN
NC score	0.062340 (rank : 192)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	249	Target Neighborhood Hits	457	Shared Neighborhood Hits	27
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SPTA2_HUMAN
NC score	0.061864 (rank : 193)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	249	Target Neighborhood Hits	888	Shared Neighborhood Hits	37
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

EFS_MOUSE
NC score	0.061285 (rank : 194)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	249	Target Neighborhood Hits	389	Shared Neighborhood Hits	24
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

AHI1_MOUSE
NC score	0.060604 (rank : 195)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	249	Target Neighborhood Hits	496	Shared Neighborhood Hits	27
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

RHG04_HUMAN
NC score	0.060601 (rank : 196)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	249	Target Neighborhood Hits	307	Shared Neighborhood Hits	23
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

PKHA2_MOUSE
NC score	0.060568 (rank : 197)	θ value	4.03905 (rank : 196)
Query Neighborhood Hits	249	Target Neighborhood Hits	116	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

OSTF1_HUMAN
NC score	0.060417 (rank : 198)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	249	Target Neighborhood Hits	466	Shared Neighborhood Hits	23
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

DBNL_HUMAN
NC score	0.060187 (rank : 199)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	249	Target Neighborhood Hits	244	Shared Neighborhood Hits	18
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

OSTF1_MOUSE
NC score	0.059630 (rank : 200)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	249	Target Neighborhood Hits	467	Shared Neighborhood Hits	23
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DBNL_MOUSE
NC score	0.058762 (rank : 201)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	249	Target Neighborhood Hits	306	Shared Neighborhood Hits	18
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

OSBL9_HUMAN
NC score	0.057975 (rank : 202)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	249	Target Neighborhood Hits	138	Shared Neighborhood Hits	23
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

SPTA1_MOUSE
NC score	0.057896 (rank : 203)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	249	Target Neighborhood Hits	675	Shared Neighborhood Hits	34
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RFFL_HUMAN
NC score	0.057568 (rank : 204)	θ value	8.99809 (rank : 241)
Query Neighborhood Hits	249	Target Neighborhood Hits	175	Shared Neighborhood Hits	31
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

SHAN1_HUMAN
NC score	0.057166 (rank : 205)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	249	Target Neighborhood Hits	1041	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

PLCG2_HUMAN
NC score	0.057098 (rank : 206)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	249	Target Neighborhood Hits	280	Shared Neighborhood Hits	15
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

SPTA1_HUMAN
NC score	0.056790 (rank : 207)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	249	Target Neighborhood Hits	748	Shared Neighborhood Hits	39
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

NOXO1_MOUSE
NC score	0.056767 (rank : 208)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	249	Target Neighborhood Hits	114	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

MYRIP_MOUSE
NC score	0.056729 (rank : 209)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	249	Target Neighborhood Hits	207	Shared Neighborhood Hits	23
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

BI2L1_MOUSE
NC score	0.056704 (rank : 210)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	249	Target Neighborhood Hits	197	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

PKHA2_HUMAN
NC score	0.056382 (rank : 211)	θ value	0.62314 (rank : 142)
Query Neighborhood Hits	249	Target Neighborhood Hits	119	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

IASPP_MOUSE
NC score	0.056112 (rank : 212)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	249	Target Neighborhood Hits	1024	Shared Neighborhood Hits	63
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CNKR1_HUMAN
NC score	0.055674 (rank : 213)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	249	Target Neighborhood Hits	154	Shared Neighborhood Hits	19
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

E41LB_HUMAN
NC score	0.054934 (rank : 214)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	249	Target Neighborhood Hits	79	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

LASP1_HUMAN
NC score	0.054849 (rank : 215)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	249	Target Neighborhood Hits	293	Shared Neighborhood Hits	22
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

BCAR1_MOUSE
NC score	0.054697 (rank : 216)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	249	Target Neighborhood Hits	438	Shared Neighborhood Hits	28
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

NOXO1_HUMAN
NC score	0.054455 (rank : 217)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	249	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

BCAR1_HUMAN
NC score	0.054364 (rank : 218)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	249	Target Neighborhood Hits	554	Shared Neighborhood Hits	32
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

E41L5_HUMAN
NC score	0.053542 (rank : 219)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	249	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HCM4, Q9H975	Gene names	EPB41L5, KIAA1548
Domain Architecture
Description	Band 4.1-like protein 5.

E41LB_MOUSE
NC score	0.053517 (rank : 220)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	249	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JMC8	Gene names	Epb41l4b, Ehm2, Epb4.1l4b
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2).

E41L3_HUMAN
NC score	0.053473 (rank : 221)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	249	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y2J2, O95713, Q9BRP5	Gene names	EPB41L3, DAL1, KIAA0987
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1).

ASPP1_MOUSE
NC score	0.053200 (rank : 222)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	249	Target Neighborhood Hits	1244	Shared Neighborhood Hits	59
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ANM2_HUMAN
NC score	0.053090 (rank : 223)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	249	Target Neighborhood Hits	175	Shared Neighborhood Hits	17
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

LASP1_MOUSE
NC score	0.053080 (rank : 224)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	249	Target Neighborhood Hits	297	Shared Neighborhood Hits	21
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

CO3A1_MOUSE
NC score	0.052877 (rank : 225)	θ value	0.21417 (rank : 127)
Query Neighborhood Hits	249	Target Neighborhood Hits	466	Shared Neighborhood Hits	45
SwissProt Accessions	P08121, Q61429, Q9CRN7	Gene names	Col3a1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

CO3A1_HUMAN
NC score	0.052828 (rank : 226)	θ value	0.62314 (rank : 140)
Query Neighborhood Hits	249	Target Neighborhood Hits	452	Shared Neighborhood Hits	42
SwissProt Accessions	P02461, Q15112, Q16403, Q6LDB3, Q6LDJ2, Q6LDJ3, Q7KZ56	Gene names	COL3A1
Domain Architecture
Description	Collagen alpha-1(III) chain precursor.

FNBP2_HUMAN
NC score	0.052741 (rank : 227)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	249	Target Neighborhood Hits	432	Shared Neighborhood Hits	28
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

41_HUMAN
NC score	0.052602 (rank : 228)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	249	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	P11171, P11176, Q14245, Q5TB35, Q5VXN8, Q8IXV9, Q9Y578, Q9Y579	Gene names	EPB41, E41P
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (EPB4.1) (4.1R).

PACN2_MOUSE
NC score	0.052455 (rank : 229)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	249	Target Neighborhood Hits	382	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

FRMD5_MOUSE
NC score	0.052296 (rank : 230)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	249	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

PACN2_HUMAN
NC score	0.052261 (rank : 231)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	249	Target Neighborhood Hits	339	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

RGL1_HUMAN
NC score	0.052158 (rank : 232)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	249	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZL6, Q9HBY3, Q9HBY4, Q9NZL5, Q9UG43, Q9Y2G6	Gene names	RGL1, KIAA0959, RGL
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

CO5A1_MOUSE
NC score	0.052098 (rank : 233)	θ value	0.21417 (rank : 128)
Query Neighborhood Hits	249	Target Neighborhood Hits	419	Shared Neighborhood Hits	36
SwissProt Accessions	O88207	Gene names	Col5a1
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(V) chain precursor.

PEX13_MOUSE
NC score	0.052077 (rank : 234)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	249	Target Neighborhood Hits	126	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

E41L2_MOUSE
NC score	0.052012 (rank : 235)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	249	Target Neighborhood Hits	459	Shared Neighborhood Hits	12
SwissProt Accessions	O70318	Gene names	Epb41l2, Epb4.1l2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

E41L3_MOUSE
NC score	0.052003 (rank : 236)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	249	Target Neighborhood Hits	250	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WV92, Q9R102	Gene names	Epb41l3, Dal1, Epb4.1l3
Domain Architecture
Description	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (DAL1P) (mDAL-1).

FRMD5_HUMAN
NC score	0.051946 (rank : 237)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	249	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

E41L1_HUMAN
NC score	0.051739 (rank : 238)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	249	Target Neighborhood Hits	180	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H4G0, O15046, Q4VXN4	Gene names	EPB41L1, KIAA0338
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

NPHP1_HUMAN
NC score	0.051502 (rank : 239)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	249	Target Neighborhood Hits	288	Shared Neighborhood Hits	22
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

41_MOUSE
NC score	0.051377 (rank : 240)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	249	Target Neighborhood Hits	184	Shared Neighborhood Hits	6
SwissProt Accessions	P48193, Q68FF1, Q6NVF5	Gene names	Epb41, Epb4.1
Domain Architecture
Description	Protein 4.1 (Band 4.1) (P4.1) (4.1R).

3BP2_HUMAN
NC score	0.051363 (rank : 241)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	249	Target Neighborhood Hits	296	Shared Neighborhood Hits	19
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

SRGP1_HUMAN
NC score	0.051322 (rank : 242)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	249	Target Neighborhood Hits	390	Shared Neighborhood Hits	25
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

E41L1_MOUSE
NC score	0.051260 (rank : 243)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	249	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z2H5	Gene names	Epb41l1, Epb4, Epb4.1l1
Domain Architecture
Description	Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N).

E41L2_HUMAN
NC score	0.051211 (rank : 244)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	249	Target Neighborhood Hits	287	Shared Neighborhood Hits	8
SwissProt Accessions	O43491	Gene names	EPB41L2
Domain Architecture
Description	Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G).

MELPH_HUMAN
NC score	0.051139 (rank : 245)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	249	Target Neighborhood Hits	145	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BV36, Q9HA71	Gene names	MLPH, SLAC2A
Domain Architecture	No domain graphic available
Description	Melanophilin (Exophilin-3) (Synaptotagmin-like protein 2a) (Slp homolog lacking C2 domains a).

CO5A1_HUMAN
NC score	0.051109 (rank : 246)	θ value	0.365318 (rank : 135)
Query Neighborhood Hits	249	Target Neighborhood Hits	434	Shared Neighborhood Hits	38
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

DGKD_HUMAN
NC score	0.050909 (rank : 247)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	249	Target Neighborhood Hits	231	Shared Neighborhood Hits	23
SwissProt Accessions	Q16760, Q14158, Q6PK55, Q8NG53	Gene names	DGKD, KIAA0145
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase delta (EC 2.7.1.107) (Diglyceride kinase delta) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase).

OGFR_HUMAN
NC score	0.050696 (rank : 248)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	249	Target Neighborhood Hits	1582	Shared Neighborhood Hits	73
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RIMB1_HUMAN
NC score	0.050564 (rank : 249)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	249	Target Neighborhood Hits	1479	Shared Neighborhood Hits	72
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CASL_HUMAN
NC score	0.050459 (rank : 250)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	249	Target Neighborhood Hits	259	Shared Neighborhood Hits	25
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

PACN3_MOUSE
NC score	0.050216 (rank : 251)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	249	Target Neighborhood Hits	380	Shared Neighborhood Hits	26
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

CO1A1_MOUSE
NC score	0.050144 (rank : 252)	θ value	0.0736092 (rank : 113)
Query Neighborhood Hits	249	Target Neighborhood Hits	457	Shared Neighborhood Hits	39
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

RGL1_MOUSE
NC score	0.050022 (rank : 253)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	249	Target Neighborhood Hits	42	Shared Neighborhood Hits	7
SwissProt Accessions	Q60695	Gene names	Rgl1, Rgl
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1).

CO1A1_HUMAN
NC score	0.047190 (rank : 254)	θ value	0.125558 (rank : 120)
Query Neighborhood Hits	249	Target Neighborhood Hits	475	Shared Neighborhood Hits	38
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CO1A2_MOUSE
NC score	0.047061 (rank : 255)	θ value	1.06291 (rank : 150)
Query Neighborhood Hits	249	Target Neighborhood Hits	388	Shared Neighborhood Hits	42
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO1A2_HUMAN
NC score	0.045942 (rank : 256)	θ value	1.81305 (rank : 164)
Query Neighborhood Hits	249	Target Neighborhood Hits	329	Shared Neighborhood Hits	36
SwissProt Accessions	P08123, P02464, Q9UEB6, Q9UPH0	Gene names	COL1A2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

CO2A1_MOUSE
NC score	0.044777 (rank : 257)	θ value	1.81305 (rank : 165)
Query Neighborhood Hits	249	Target Neighborhood Hits	483	Shared Neighborhood Hits	44
SwissProt Accessions	P28481	Gene names	Col2a1
Domain Architecture
Description	Collagen alpha-1(II) chain precursor [Contains: Chondrocalcin].

AKAP2_HUMAN
NC score	0.044047 (rank : 258)	θ value	0.0330416 (rank : 107)
Query Neighborhood Hits	249	Target Neighborhood Hits	507	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

OGFR_MOUSE
NC score	0.042630 (rank : 259)	θ value	0.279714 (rank : 134)
Query Neighborhood Hits	249	Target Neighborhood Hits	584	Shared Neighborhood Hits	37
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

CO5A3_HUMAN
NC score	0.042408 (rank : 260)	θ value	0.21417 (rank : 129)
Query Neighborhood Hits	249	Target Neighborhood Hits	433	Shared Neighborhood Hits	40
SwissProt Accessions	P25940, Q9NZQ6	Gene names	COL5A3
Domain Architecture
Description	Collagen alpha-3(V) chain precursor.

COBA1_HUMAN
NC score	0.042216 (rank : 261)	θ value	1.06291 (rank : 151)
Query Neighborhood Hits	249	Target Neighborhood Hits	491	Shared Neighborhood Hits	40
SwissProt Accessions	P12107, Q14034, Q9UIT4, Q9UIT5, Q9UIT6	Gene names	COL11A1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COBA1_MOUSE
NC score	0.041930 (rank : 262)	θ value	1.06291 (rank : 152)
Query Neighborhood Hits	249	Target Neighborhood Hits	487	Shared Neighborhood Hits	40
SwissProt Accessions	Q61245, Q64047	Gene names	Col11a1
Domain Architecture
Description	Collagen alpha-1(XI) chain precursor.

COBA2_HUMAN
NC score	0.041573 (rank : 263)	θ value	0.47712 (rank : 138)
Query Neighborhood Hits	249	Target Neighborhood Hits	408	Shared Neighborhood Hits	42
SwissProt Accessions	P13942, Q07751, Q13271, Q13272, Q13273, Q99866, Q9UIP9	Gene names	COL11A2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

COBA2_MOUSE
NC score	0.041560 (rank : 264)	θ value	0.365318 (rank : 136)
Query Neighborhood Hits	249	Target Neighborhood Hits	501	Shared Neighborhood Hits	43
SwissProt Accessions	Q64739, Q61432, Q9Z1W0	Gene names	Col11a2
Domain Architecture
Description	Collagen alpha-2(XI) chain precursor.

SYTL4_HUMAN
NC score	0.041509 (rank : 265)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	249	Target Neighborhood Hits	138	Shared Neighborhood Hits	19
SwissProt Accessions	Q96C24, Q5H9J3, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1	Gene names	SYTL4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

DGKK_HUMAN
NC score	0.039407 (rank : 266)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	249	Target Neighborhood Hits	378	Shared Neighborhood Hits	24
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

TCOF_MOUSE
NC score	0.038811 (rank : 267)	θ value	0.0563607 (rank : 109)
Query Neighborhood Hits	249	Target Neighborhood Hits	471	Shared Neighborhood Hits	28
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

CO5A2_HUMAN
NC score	0.036415 (rank : 268)	θ value	1.38821 (rank : 155)
Query Neighborhood Hits	249	Target Neighborhood Hits	760	Shared Neighborhood Hits	50
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

RNF37_MOUSE
NC score	0.035923 (rank : 269)	θ value	0.21417 (rank : 131)
Query Neighborhood Hits	249	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q925F4	Gene names	Ubox5, Rnf37, Ubce7ip5, Uip5
Domain Architecture
Description	RING finger protein 37 (Ubiquitin-conjugating enzyme 7-interacting protein 5) (UbcM4-interacting protein 5) (U-box domain-containing protein 5).

OPTN_MOUSE
NC score	0.034815 (rank : 270)	θ value	0.125558 (rank : 121)
Query Neighborhood Hits	249	Target Neighborhood Hits	1120	Shared Neighborhood Hits	26
SwissProt Accessions	Q8K3K8	Gene names	Optn
Domain Architecture	No domain graphic available
Description	Optineurin.

SCAR3_HUMAN
NC score	0.034614 (rank : 271)	θ value	4.03905 (rank : 197)
Query Neighborhood Hits	249	Target Neighborhood Hits	205	Shared Neighborhood Hits	33
SwissProt Accessions	Q6AZY7, Q9UM15, Q9UM16	Gene names	SCARA3, CSR
Domain Architecture	No domain graphic available
Description	Scavenger receptor class A member 3 (Cellular stress response gene protein).

CO4A3_HUMAN
NC score	0.034387 (rank : 272)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	249	Target Neighborhood Hits	421	Shared Neighborhood Hits	37
SwissProt Accessions	Q01955, Q9BQT2	Gene names	COL4A3
Domain Architecture
Description	Collagen alpha-3(IV) chain precursor (Goodpasture antigen).

CENB5_HUMAN
NC score	0.034385 (rank : 273)	θ value	3.0926 (rank : 180)
Query Neighborhood Hits	249	Target Neighborhood Hits	395	Shared Neighborhood Hits	20
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

ELN_MOUSE
NC score	0.033470 (rank : 274)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	249	Target Neighborhood Hits	105	Shared Neighborhood Hits	23
SwissProt Accessions	P54320	Gene names	Eln
Domain Architecture	No domain graphic available
Description	Elastin precursor (Tropoelastin).

SCAR3_MOUSE
NC score	0.033344 (rank : 275)	θ value	8.99809 (rank : 243)
Query Neighborhood Hits	249	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q8C850, Q8C6N1	Gene names	Scara3
Domain Architecture	No domain graphic available
Description	Scavenger receptor class A member 3.

CD19_HUMAN
NC score	0.033267 (rank : 276)	θ value	0.125558 (rank : 119)
Query Neighborhood Hits	249	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	P15391, Q96S68, Q9BRD6	Gene names	CD19
Domain Architecture
Description	B-lymphocyte antigen CD19 precursor (Differentiation antigen CD19) (B- lymphocyte surface antigen B4) (Leu-12).

CO4A6_HUMAN
NC score	0.033224 (rank : 277)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	249	Target Neighborhood Hits	318	Shared Neighborhood Hits	35
SwissProt Accessions	Q14031, Q12823, Q14053, Q5JYH6, Q9NQM5, Q9NTX3, Q9UJ76, Q9UMG6, Q9Y4L4	Gene names	COL4A6
Domain Architecture
Description	Collagen alpha-6(IV) chain precursor.

CO002_HUMAN
NC score	0.032912 (rank : 278)	θ value	1.81305 (rank : 163)
Query Neighborhood Hits	249	Target Neighborhood Hits	387	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

ERC2_MOUSE
NC score	0.031937 (rank : 279)	θ value	3.0926 (rank : 183)
Query Neighborhood Hits	249	Target Neighborhood Hits	1166	Shared Neighborhood Hits	32
SwissProt Accessions	Q6PH08, Q80U20, Q8CCP1	Gene names	Erc2, Cast1, D14Ertd171e, Kiaa0378
Domain Architecture	No domain graphic available
Description	ERC protein 2 (CAZ-associated structural protein 1) (CAST1).

SGIP1_HUMAN
NC score	0.031340 (rank : 280)	θ value	0.125558 (rank : 122)
Query Neighborhood Hits	249	Target Neighborhood Hits	198	Shared Neighborhood Hits	14
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

RENT2_HUMAN
NC score	0.031080 (rank : 281)	θ value	2.36792 (rank : 175)
Query Neighborhood Hits	249	Target Neighborhood Hits	618	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HAU5, Q8N8U1, Q9H1J2, Q9NWL1, Q9P2D9, Q9Y4M9	Gene names	UPF2, KIAA1408, RENT2
Domain Architecture	No domain graphic available
Description	Regulator of nonsense transcripts 2 (Nonsense mRNA reducing factor 2) (Up-frameshift suppressor 2 homolog) (hUpf2).

CO8A2_HUMAN
NC score	0.031077 (rank : 282)	θ value	8.99809 (rank : 236)
Query Neighborhood Hits	249	Target Neighborhood Hits	299	Shared Neighborhood Hits	35
SwissProt Accessions	P25067, Q8TEJ5	Gene names	COL8A2
Domain Architecture
Description	Collagen alpha-2(VIII) chain precursor (Endothelial collagen).

VEZA_HUMAN
NC score	0.030749 (rank : 283)	θ value	1.38821 (rank : 160)
Query Neighborhood Hits	249	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HBM0, Q9H2F4, Q9H2U5, Q9NT70, Q9NVW0, Q9UF91	Gene names	VEZT
Domain Architecture	No domain graphic available
Description	Vezatin.

ERC2_HUMAN
NC score	0.029871 (rank : 284)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	249	Target Neighborhood Hits	1156	Shared Neighborhood Hits	30
SwissProt Accessions	O15083, Q86TK4	Gene names	ERC2, KIAA0378
Domain Architecture	No domain graphic available
Description	ERC protein 2.

SYTL4_MOUSE
NC score	0.029241 (rank : 285)	θ value	8.99809 (rank : 247)
Query Neighborhood Hits	249	Target Neighborhood Hits	137	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R0Q1, Q8R321, Q9R0Q0	Gene names	Sytl4, Slp4
Domain Architecture
Description	Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin).

HAIR_MOUSE
NC score	0.028991 (rank : 286)	θ value	0.0563607 (rank : 108)
Query Neighborhood Hits	249	Target Neighborhood Hits	97	Shared Neighborhood Hits	7
SwissProt Accessions	Q61645, Q80Y47	Gene names	Hr
Domain Architecture
Description	Protein hairless.

APC_HUMAN
NC score	0.028923 (rank : 287)	θ value	0.125558 (rank : 118)
Query Neighborhood Hits	249	Target Neighborhood Hits	603	Shared Neighborhood Hits	20
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

CN140_MOUSE
NC score	0.027799 (rank : 288)	θ value	5.27518 (rank : 204)
Query Neighborhood Hits	249	Target Neighborhood Hits	152	Shared Neighborhood Hits	11
SwissProt Accessions	Q8CCG1, Q8CCM8	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf140 homolog.

DTBP1_HUMAN
NC score	0.025511 (rank : 289)	θ value	0.62314 (rank : 141)
Query Neighborhood Hits	249	Target Neighborhood Hits	185	Shared Neighborhood Hits	9
SwissProt Accessions	Q96EV8, Q96NV2, Q9H0U2, Q9H3J5	Gene names	DTNBP1
Domain Architecture
Description	Dystrobrevin-binding protein 1 (Dysbindin) (Hermansky-Pudlak syndrome 7 protein).

K0323_MOUSE
NC score	0.025360 (rank : 290)	θ value	0.21417 (rank : 130)
Query Neighborhood Hits	249	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q80U38, Q8BGJ6, Q8C082	Gene names	Kiaa0323
Domain Architecture	No domain graphic available
Description	Protein KIAA0323.

SRRM2_MOUSE
NC score	0.025297 (rank : 291)	θ value	0.21417 (rank : 132)
Query Neighborhood Hits	249	Target Neighborhood Hits	1470	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

MBD6_HUMAN
NC score	0.023982 (rank : 292)	θ value	1.38821 (rank : 157)
Query Neighborhood Hits	249	Target Neighborhood Hits	349	Shared Neighborhood Hits	17
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

ARI3A_HUMAN
NC score	0.023702 (rank : 293)	θ value	0.279714 (rank : 133)
Query Neighborhood Hits	249	Target Neighborhood Hits	80	Shared Neighborhood Hits	4
SwissProt Accessions	Q99856, Q8IZA7	Gene names	ARID3A, DRIL1, DRX, E2FBP1
Domain Architecture
Description	AT-rich interactive domain-containing protein 3A (ARID domain- containing protein 3A) (B-cell regulator of IgH transcription) (Bright) (E2F-binding protein 1).

PGCA_HUMAN
NC score	0.023621 (rank : 294)	θ value	0.0148317 (rank : 105)
Query Neighborhood Hits	249	Target Neighborhood Hits	821	Shared Neighborhood Hits	29
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

HAIR_HUMAN
NC score	0.022975 (rank : 295)	θ value	1.81305 (rank : 166)
Query Neighborhood Hits	249	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

SYTL5_MOUSE
NC score	0.021641 (rank : 296)	θ value	0.62314 (rank : 143)
Query Neighborhood Hits	249	Target Neighborhood Hits	154	Shared Neighborhood Hits	12
SwissProt Accessions	Q80T23, Q812E5	Gene names	Sytl5, Slp5
Domain Architecture
Description	Synaptotagmin-like protein 5.

CIC_HUMAN
NC score	0.021289 (rank : 297)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	249	Target Neighborhood Hits	992	Shared Neighborhood Hits	50
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

LCOR_HUMAN
NC score	0.020806 (rank : 298)	θ value	0.813845 (rank : 145)
Query Neighborhood Hits	249	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JN0, Q5VW16, Q7Z723, Q86T32, Q86T33, Q8N3L6	Gene names	LCOR, KIAA1795, MLR2
Domain Architecture	No domain graphic available
Description	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2).

PELP1_HUMAN
NC score	0.019655 (rank : 299)	θ value	1.38821 (rank : 158)
Query Neighborhood Hits	249	Target Neighborhood Hits	596	Shared Neighborhood Hits	18
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

MAML1_MOUSE
NC score	0.019283 (rank : 300)	θ value	0.813845 (rank : 146)
Query Neighborhood Hits	249	Target Neighborhood Hits	279	Shared Neighborhood Hits	22
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

CEL_HUMAN
NC score	0.018969 (rank : 301)	θ value	0.0736092 (rank : 112)
Query Neighborhood Hits	249	Target Neighborhood Hits	896	Shared Neighborhood Hits	47
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

ZIMP7_HUMAN
NC score	0.018761 (rank : 302)	θ value	0.62314 (rank : 144)
Query Neighborhood Hits	249	Target Neighborhood Hits	290	Shared Neighborhood Hits	31
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

SPRE2_MOUSE
NC score	0.016959 (rank : 303)	θ value	1.81305 (rank : 169)
Query Neighborhood Hits	249	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q924S7	Gene names	Spred2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

GCYB2_HUMAN
NC score	0.016409 (rank : 304)	θ value	0.163984 (rank : 124)
Query Neighborhood Hits	249	Target Neighborhood Hits	61	Shared Neighborhood Hits	6
SwissProt Accessions	O75343, Q9NZ64	Gene names	GUCY1B2
Domain Architecture
Description	Guanylate cyclase soluble subunit beta-2 (EC 4.6.1.2) (GCS-beta-2).

FMN2_HUMAN
NC score	0.016072 (rank : 305)	θ value	1.38821 (rank : 156)
Query Neighborhood Hits	249	Target Neighborhood Hits	484	Shared Neighborhood Hits	23
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

CDSN_MOUSE
NC score	0.015718 (rank : 306)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	249	Target Neighborhood Hits	131	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

3BP5_MOUSE
NC score	0.015579 (rank : 307)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	249	Target Neighborhood Hits	346	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z131, Q8C903, Q8VCZ0	Gene names	Sh3bp5, Sab
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

FA13A_MOUSE
NC score	0.015248 (rank : 308)	θ value	2.36792 (rank : 173)
Query Neighborhood Hits	249	Target Neighborhood Hits	83	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

RNF31_HUMAN
NC score	0.014979 (rank : 309)	θ value	2.36792 (rank : 176)
Query Neighborhood Hits	249	Target Neighborhood Hits	110	Shared Neighborhood Hits	11
SwissProt Accessions	Q96EP0, Q86VI2, Q8TEI0, Q96GB4, Q96NF1, Q9H5F1, Q9NWD2	Gene names	RNF31, ZIBRA
Domain Architecture
Description	RING finger protein 31 (Zinc in-between-RING-finger ubiquitin- associated domain protein).

ASPX_HUMAN
NC score	0.014774 (rank : 310)	θ value	3.0926 (rank : 179)
Query Neighborhood Hits	249	Target Neighborhood Hits	148	Shared Neighborhood Hits	9
SwissProt Accessions	P26436	Gene names	ACRV1
Domain Architecture
Description	Acrosomal protein SP-10 precursor (Acrosomal vesicle protein 1).

3BP5_HUMAN
NC score	0.014486 (rank : 311)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	249	Target Neighborhood Hits	375	Shared Neighborhood Hits	8
SwissProt Accessions	O60239	Gene names	SH3BP5, SAB
Domain Architecture
Description	SH3 domain-binding protein 5 (SH3 domain-binding protein that preferentially associates with BTK).

CHD1_MOUSE
NC score	0.013531 (rank : 312)	θ value	0.0252991 (rank : 106)
Query Neighborhood Hits	249	Target Neighborhood Hits	266	Shared Neighborhood Hits	10
SwissProt Accessions	P40201	Gene names	Chd1, Chd-1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

PGCA_MOUSE
NC score	0.013359 (rank : 313)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	249	Target Neighborhood Hits	643	Shared Neighborhood Hits	33
SwissProt Accessions	Q61282, Q64021	Gene names	Agc1, Agc
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP).

SETBP_HUMAN
NC score	0.013207 (rank : 314)	θ value	8.99809 (rank : 244)
Query Neighborhood Hits	249	Target Neighborhood Hits	305	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

AP1B1_MOUSE
NC score	0.012806 (rank : 315)	θ value	0.163984 (rank : 123)
Query Neighborhood Hits	249	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	O35643, Q922E2	Gene names	Ap1b1, Adtb1
Domain Architecture
Description	AP-1 complex subunit beta-1 (Adapter-related protein complex 1 beta-1 subunit) (Beta-adaptin 1) (Adaptor protein complex AP-1 beta-1 subunit) (Golgi adaptor HA1/AP1 adaptin beta subunit) (Clathrin assembly protein complex 1 beta large chain).

ILF3_MOUSE
NC score	0.011984 (rank : 316)	θ value	2.36792 (rank : 174)
Query Neighborhood Hits	249	Target Neighborhood Hits	71	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1X4, Q80VD5, Q812A1, Q8BP80, Q8C2H8, Q8K588	Gene names	Ilf3
Domain Architecture
Description	Interleukin enhancer-binding factor 3.

ANKZ1_HUMAN
NC score	0.011878 (rank : 317)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	249	Target Neighborhood Hits	236	Shared Neighborhood Hits	10
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

MYO9B_MOUSE
NC score	0.011326 (rank : 318)	θ value	4.03905 (rank : 195)
Query Neighborhood Hits	249	Target Neighborhood Hits	311	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CJ006_MOUSE
NC score	0.011100 (rank : 319)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	249	Target Neighborhood Hits	141	Shared Neighborhood Hits	5
SwissProt Accessions	Q6P9P0, Q8C041, Q8C0J5	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf6 homolog.

SPRE2_HUMAN
NC score	0.010520 (rank : 320)	θ value	4.03905 (rank : 198)
Query Neighborhood Hits	249	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z698, Q2NKX6	Gene names	SPRED2
Domain Architecture	No domain graphic available
Description	Sprouty-related, EVH1 domain-containing protein 2 (Spred-2).

LEG3_MOUSE
NC score	0.010505 (rank : 321)	θ value	8.99809 (rank : 239)
Query Neighborhood Hits	249	Target Neighborhood Hits	113	Shared Neighborhood Hits	17
SwissProt Accessions	P16110	Gene names	Lgals3
Domain Architecture
Description	Galectin-3 (Galactose-specific lectin 3) (Mac-2 antigen) (IgE-binding protein) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Laminin-binding protein) (Lectin L-29) (L-34 galactoside-binding lectin).

ZBP1_HUMAN
NC score	0.010309 (rank : 322)	θ value	5.27518 (rank : 215)
Query Neighborhood Hits	249	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H171, Q5JY39, Q9BYW4	Gene names	ZBP1, C20orf183, DLM1
Domain Architecture
Description	Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1).

GBF1_HUMAN
NC score	0.010288 (rank : 323)	θ value	1.06291 (rank : 153)
Query Neighborhood Hits	249	Target Neighborhood Hits	142	Shared Neighborhood Hits	3
SwissProt Accessions	Q92538, Q5VXX3, Q96CK6, Q96HZ3, Q9H473	Gene names	GBF1, KIAA0248
Domain Architecture
Description	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (BFA-resistant GEF 1).

SALL3_HUMAN
NC score	0.009669 (rank : 324)	θ value	1.81305 (rank : 168)
Query Neighborhood Hits	249	Target Neighborhood Hits	1066	Shared Neighborhood Hits	54
SwissProt Accessions	Q9BXA9, Q9UGH1	Gene names	SALL3
Domain Architecture	No domain graphic available
Description	Sal-like protein 3 (Zinc finger protein SALL3) (hSALL3).

MLH3_HUMAN
NC score	0.009609 (rank : 325)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	249	Target Neighborhood Hits	42	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHC1, P49751, Q56DK9, Q9P292, Q9UHC0	Gene names	MLH3
Domain Architecture
Description	DNA mismatch repair protein Mlh3 (MutL protein homolog 3).

ASCL1_HUMAN
NC score	0.009602 (rank : 326)	θ value	3.0926 (rank : 178)
Query Neighborhood Hits	249	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

CHD1_HUMAN
NC score	0.009558 (rank : 327)	θ value	3.0926 (rank : 181)
Query Neighborhood Hits	249	Target Neighborhood Hits	337	Shared Neighborhood Hits	12
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

EGLN1_HUMAN
NC score	0.009297 (rank : 328)	θ value	3.0926 (rank : 182)
Query Neighborhood Hits	249	Target Neighborhood Hits	61	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZT9, Q8N3M8, Q9BZS8, Q9BZT0	Gene names	EGLN1, C1orf12
Domain Architecture
Description	Egl nine homolog 1 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-prolyl hydroxylase 2) (HIF-PH2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20).

NCA11_MOUSE
NC score	0.009151 (rank : 329)	θ value	3.0926 (rank : 184)
Query Neighborhood Hits	249	Target Neighborhood Hits	661	Shared Neighborhood Hits	13
SwissProt Accessions	P13595, Q61949	Gene names	Ncam1, Ncam
Domain Architecture
Description	Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM 180) (NCAM-180).

ILF3_HUMAN
NC score	0.009004 (rank : 330)	θ value	8.99809 (rank : 238)
Query Neighborhood Hits	249	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	Q12906, O43409, Q6P1X1, Q86XY7, Q99544, Q99545, Q9BZH4, Q9BZH5, Q9NQ95, Q9NQ96, Q9NQ97, Q9NQ98, Q9NQ99, Q9NQA0, Q9NQA1, Q9NQA2, Q9NRN2, Q9NRN3, Q9NRN4, Q9UMZ9, Q9UN00, Q9UN84, Q9UNA2	Gene names	ILF3, DRBF, MPHOSPH4, NF90
Domain Architecture
Description	Interleukin enhancer-binding factor 3 (Nuclear factor of activated T- cells 90 kDa) (NF-AT-90) (Double-stranded RNA-binding protein 76) (DRBP76) (Translational control protein 80) (TCP80) (Nuclear factor associated with dsRNA) (NFAR) (M-phase phosphoprotein 4) (MPP4).

CEBPD_HUMAN
NC score	0.008296 (rank : 331)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	249	Target Neighborhood Hits	135	Shared Neighborhood Hits	8
SwissProt Accessions	P49716, Q14937	Gene names	CEBPD
Domain Architecture
Description	CCAAT/enhancer-binding protein delta (C/EBP delta) (Nuclear factor NF- IL6-beta) (NF-IL6-beta).

IF39_MOUSE
NC score	0.008273 (rank : 332)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	249	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	Q8JZQ9, Q922K2	Gene names	Eif3s9
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 3 subunit 9 (eIF-3 eta) (eIF3 p116).

EGLN2_HUMAN
NC score	0.007988 (rank : 333)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	249	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q96KS0, Q8WWY4, Q9BV14	Gene names	EGLN2, EIT6
Domain Architecture
Description	Egl nine homolog 2 (EC 1.14.11.-) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-prolyl hydroxylase 1) (HIF-PH1) (HPH-3) (Prolyl hydroxylase domain-containing protein 1) (PHD1) (Estrogen-induced tag 6).

RNF6_HUMAN
NC score	0.007491 (rank : 334)	θ value	3.0926 (rank : 185)
Query Neighborhood Hits	249	Target Neighborhood Hits	157	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Y252, Q9UF41	Gene names	RNF6
Domain Architecture
Description	RING finger protein 6 (RING-H2 protein).

ASCL1_MOUSE
NC score	0.007425 (rank : 335)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	249	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

AIM1_HUMAN
NC score	0.007336 (rank : 336)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	249	Target Neighborhood Hits	247	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y4K1, O00296, Q5VWJ2	Gene names	AIM1
Domain Architecture
Description	Absent in melanoma 1 protein.

TGON1_MOUSE
NC score	0.006680 (rank : 337)	θ value	8.99809 (rank : 248)
Query Neighborhood Hits	249	Target Neighborhood Hits	243	Shared Neighborhood Hits	13
SwissProt Accessions	Q62313	Gene names	Tgoln1, Ttgn1
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 1 precursor (TGN38A).

TRI32_HUMAN
NC score	0.006031 (rank : 338)	θ value	5.27518 (rank : 214)
Query Neighborhood Hits	249	Target Neighborhood Hits	264	Shared Neighborhood Hits	11
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

RU17_MOUSE
NC score	0.005657 (rank : 339)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	249	Target Neighborhood Hits	278	Shared Neighborhood Hits	11
SwissProt Accessions	Q62376, Q3UIW4	Gene names	Snrp70
Domain Architecture	No domain graphic available
Description	U1 small nuclear ribonucleoprotein 70 kDa (U1 SNRNP 70 kDa) (snRNP70).

MARCS_HUMAN
NC score	0.005627 (rank : 340)	θ value	8.99809 (rank : 240)
Query Neighborhood Hits	249	Target Neighborhood Hits	204	Shared Neighborhood Hits	10
SwissProt Accessions	P29966, Q2LA83, Q5TDB7	Gene names	MARCKS, MACS, PRKCSL
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate, 80 kDa protein, light chain) (PKCSL) (80K-L protein).

SNIP_MOUSE
NC score	0.005253 (rank : 341)	θ value	8.99809 (rank : 245)
Query Neighborhood Hits	249	Target Neighborhood Hits	319	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

ZBT40_HUMAN
NC score	0.005252 (rank : 342)	θ value	1.38821 (rank : 161)
Query Neighborhood Hits	249	Target Neighborhood Hits	949	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NUA8, O75066, Q5TFU5, Q8N1R1	Gene names	ZBTB40, KIAA0478
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 40.

MAST1_MOUSE
NC score	0.005022 (rank : 343)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	249	Target Neighborhood Hits	1123	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R1L5, Q7TQG9, Q80TN0	Gene names	Mast1, Kiaa0973, Sast
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase).

WNK2_HUMAN
NC score	0.004770 (rank : 344)	θ value	1.06291 (rank : 154)
Query Neighborhood Hits	249	Target Neighborhood Hits	1407	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ZBTB1_HUMAN
NC score	0.004144 (rank : 345)	θ value	0.813845 (rank : 147)
Query Neighborhood Hits	249	Target Neighborhood Hits	805	Shared Neighborhood Hits	31
SwissProt Accessions	Q9Y2K1, Q86SW8	Gene names	ZBTB1, KIAA0997
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ZEP2_HUMAN
NC score	0.004062 (rank : 346)	θ value	1.81305 (rank : 170)
Query Neighborhood Hits	249	Target Neighborhood Hits	937	Shared Neighborhood Hits	35
SwissProt Accessions	P31629, Q02646, Q5THT5, Q9NS05	Gene names	HIVEP2
Domain Architecture	No domain graphic available
Description	Human immunodeficiency virus type I enhancer-binding protein 2 (HIV- EP2) (MHC-binding protein 2) (MBP-2).

PAK4_HUMAN
NC score	0.004042 (rank : 347)	θ value	0.0736092 (rank : 114)
Query Neighborhood Hits	249	Target Neighborhood Hits	924	Shared Neighborhood Hits	15
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

PCAF_HUMAN
NC score	0.003893 (rank : 348)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	249	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q92831, Q6NSK1	Gene names	PCAF
Domain Architecture
Description	Histone acetyltransferase PCAF (EC 2.3.1.48) (P300/CBP-associated factor) (P/CAF) (Histone acetylase PCAF).

DHX36_MOUSE
NC score	0.003383 (rank : 349)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	249	Target Neighborhood Hits	114	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VHK9, Q6ZPP7, Q9CSE8	Gene names	Dhx36, Ddx36, Kiaa1488, Mlel1
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DHX36 (EC 3.6.1.-) (DEAH box protein 36) (MLE-like protein 1) (RNA helicase associated with AU-rich element ARE).

PRGR_HUMAN
NC score	0.002667 (rank : 350)	θ value	1.38821 (rank : 159)
Query Neighborhood Hits	249	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	P06401, Q9UPF7	Gene names	PGR, NR3C3
Domain Architecture
Description	Progesterone receptor (PR).

ZN440_HUMAN
NC score	0.002585 (rank : 351)	θ value	0.813845 (rank : 149)
Query Neighborhood Hits	249	Target Neighborhood Hits	750	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IYI8, Q8N1R9	Gene names	ZNF440
Domain Architecture
Description	Zinc finger protein 440.

ZBTB1_MOUSE
NC score	0.002579 (rank : 352)	θ value	3.0926 (rank : 187)
Query Neighborhood Hits	249	Target Neighborhood Hits	795	Shared Neighborhood Hits	30
SwissProt Accessions	Q91VL9, Q8CDP7, Q99LD2	Gene names	Zbtb1
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 1.

ZN563_HUMAN
NC score	0.002260 (rank : 353)	θ value	1.81305 (rank : 172)
Query Neighborhood Hits	249	Target Neighborhood Hits	754	Shared Neighborhood Hits	32
SwissProt Accessions	Q8TA94, Q8NAT7	Gene names	ZNF563
Domain Architecture	No domain graphic available
Description	Zinc finger protein 563.

SALL1_MOUSE
NC score	0.002072 (rank : 354)	θ value	8.99809 (rank : 242)
Query Neighborhood Hits	249	Target Neighborhood Hits	826	Shared Neighborhood Hits	36
SwissProt Accessions	Q9ER74, Q920R5	Gene names	Sall1, Sal3
Domain Architecture
Description	Sal-like protein 1 (Zinc finger protein Spalt-3) (Sal-3) (MSal-3).

ZN433_HUMAN
NC score	0.002019 (rank : 355)	θ value	0.813845 (rank : 148)
Query Neighborhood Hits	249	Target Neighborhood Hits	782	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N7K0	Gene names	ZNF433
Domain Architecture
Description	Zinc finger protein 433.

ZN136_HUMAN
NC score	0.001862 (rank : 356)	θ value	2.36792 (rank : 177)
Query Neighborhood Hits	249	Target Neighborhood Hits	739	Shared Neighborhood Hits	32
SwissProt Accessions	P52737	Gene names	ZNF136
Domain Architecture
Description	Zinc finger protein 136.

ZN442_HUMAN
NC score	0.001721 (rank : 357)	θ value	1.81305 (rank : 171)
Query Neighborhood Hits	249	Target Neighborhood Hits	744	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H7R0	Gene names	ZNF442
Domain Architecture
Description	Zinc finger protein 442.

ZNF70_HUMAN
NC score	0.001640 (rank : 358)	θ value	4.03905 (rank : 200)
Query Neighborhood Hits	249	Target Neighborhood Hits	760	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UC06	Gene names	ZNF70
Domain Architecture	No domain graphic available
Description	Zinc finger protein 70 (Zinc finger protein N27C7-1).

ZNF14_HUMAN
NC score	0.001580 (rank : 359)	θ value	8.99809 (rank : 249)
Query Neighborhood Hits	249	Target Neighborhood Hits	760	Shared Neighborhood Hits	37
SwissProt Accessions	P17017, Q9ULZ5	Gene names	ZNF14, GIOT4, KOX6
Domain Architecture
Description	Zinc finger protein 14 (Zinc finger protein KOX6) (Gonadotropin- inducible transcription repressor 4) (GIOT-4).

ZN691_MOUSE
NC score	0.001506 (rank : 360)	θ value	1.38821 (rank : 162)
Query Neighborhood Hits	249	Target Neighborhood Hits	745	Shared Neighborhood Hits	30
SwissProt Accessions	Q3TDE8, Q3TAT2, Q8BIB1	Gene names	Znf691, Zfp691
Domain Architecture	No domain graphic available
Description	Zinc finger protein 691.

ZN700_HUMAN
NC score	0.001417 (rank : 361)	θ value	5.27518 (rank : 220)
Query Neighborhood Hits	249	Target Neighborhood Hits	772	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H0M5	Gene names	ZNF700
Domain Architecture	No domain graphic available
Description	Zinc finger protein 700.

ZIM3_HUMAN
NC score	0.001364 (rank : 362)	θ value	3.0926 (rank : 188)
Query Neighborhood Hits	249	Target Neighborhood Hits	765	Shared Neighborhood Hits	29
SwissProt Accessions	Q96PE6	Gene names	ZIM3
Domain Architecture
Description	Zinc finger imprinted 3.

HIC1_MOUSE
NC score	0.001292 (rank : 363)	θ value	4.03905 (rank : 194)
Query Neighborhood Hits	249	Target Neighborhood Hits	863	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R1Y5, Q9R1Y6, Q9R2B0	Gene names	Hic1
Domain Architecture
Description	Hypermethylated in cancer 1 protein (Hic-1).

ZBT7B_MOUSE
NC score	0.001041 (rank : 364)	θ value	3.0926 (rank : 186)
Query Neighborhood Hits	249	Target Neighborhood Hits	792	Shared Neighborhood Hits	29
SwissProt Accessions	Q64321, Q80VV5	Gene names	Zbtb7b, Thpok, Zfp67
Domain Architecture	No domain graphic available
Description	Zinc finger and BTB domain-containing protein 7B (Zinc finger protein 67) (Zfp-67) (Zinc finger protein Th-POK) (T-helper-inducing POZ/Krueppel-like factor) (Krueppel-related zinc finger protein cKrox) (c-Krox).

ZNF26_HUMAN
NC score	0.000976 (rank : 365)	θ value	5.27518 (rank : 221)
Query Neighborhood Hits	249	Target Neighborhood Hits	736	Shared Neighborhood Hits	29
SwissProt Accessions	P17031, Q9NWL3	Gene names	ZNF26, KOX20
Domain Architecture	No domain graphic available
Description	Zinc finger protein 26 (Zinc finger protein KOX20).

ZN599_HUMAN
NC score	0.000661 (rank : 366)	θ value	4.03905 (rank : 199)
Query Neighborhood Hits	249	Target Neighborhood Hits	744	Shared Neighborhood Hits	30
SwissProt Accessions	Q96NL3, Q569K0, Q5PRG1	Gene names	ZNF599
Domain Architecture	No domain graphic available
Description	Zinc finger protein 599.

HIC2_MOUSE
NC score	0.000388 (rank : 367)	θ value	8.99809 (rank : 237)
Query Neighborhood Hits	249	Target Neighborhood Hits	821	Shared Neighborhood Hits	31
SwissProt Accessions	Q9JLZ6, Q3U030, Q3ULP4, Q5K036, Q8BSZ9, Q8C3T5	Gene names	Hic2, Kiaa1020
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2).

ZN691_HUMAN
NC score	0.000336 (rank : 368)	θ value	5.27518 (rank : 219)
Query Neighborhood Hits	249	Target Neighborhood Hits	745	Shared Neighborhood Hits	28
SwissProt Accessions	Q5VV52, O95878, Q9NWE8	Gene names	ZNF691
Domain Architecture	No domain graphic available
Description	Zinc finger protein 691.

ZN540_HUMAN
NC score	0.000328 (rank : 369)	θ value	5.27518 (rank : 218)
Query Neighborhood Hits	249	Target Neighborhood Hits	759	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NDQ6, Q6ZN36, Q7Z3C8, Q86T31	Gene names	ZNF540
Domain Architecture	No domain graphic available
Description	Zinc finger protein 540.

ZN222_HUMAN
NC score	0.000270 (rank : 370)	θ value	6.88961 (rank : 233)
Query Neighborhood Hits	249	Target Neighborhood Hits	747	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UK12, Q9P1U5	Gene names	ZNF222
Domain Architecture
Description	Zinc finger protein 222.

ZN140_HUMAN
NC score	0.000198 (rank : 371)	θ value	6.88961 (rank : 232)
Query Neighborhood Hits	249	Target Neighborhood Hits	741	Shared Neighborhood Hits	32
SwissProt Accessions	P52738	Gene names	ZNF140
Domain Architecture
Description	Zinc finger protein 140.

ZFP14_MOUSE
NC score	0.000134 (rank : 372)	θ value	5.27518 (rank : 216)
Query Neighborhood Hits	249	Target Neighborhood Hits	746	Shared Neighborhood Hits	28
SwissProt Accessions	P10755, Q5DTW6, Q8BFZ5	Gene names	Zfp14, Kiaa1559, Krox-9, Zfp-14
Domain Architecture	No domain graphic available
Description	Zinc finger protein 14 (Zfp-14) (Krox-9 protein).

ZN224_HUMAN
NC score	0.000130 (rank : 373)	θ value	5.27518 (rank : 217)
Query Neighborhood Hits	249	Target Neighborhood Hits	808	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZL3, Q86V10, Q8IZC8, Q9UID9, Q9Y2P6	Gene names	ZNF224, BMZF2, ZNF255
Domain Architecture
Description	Zinc finger protein 224 (Zinc finger protein 255) (Bone marrow zinc finger 2) (BMZF-2).

FOXQ1_HUMAN
NC score	-0.000159 (rank : 374)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	249	Target Neighborhood Hits	115	Shared Neighborhood Hits	5
SwissProt Accessions	Q9C009, Q9NS06	Gene names	FOXQ1, HFH1
Domain Architecture
Description	Forkhead box protein Q1 (Hepatocyte nuclear factor 3 forkhead homolog 1) (HNF-3/forkhead-like protein 1) (HFH-1).

EPHAA_HUMAN
NC score	-0.000907 (rank : 375)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	249	Target Neighborhood Hits	960	Shared Neighborhood Hits	14
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).