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Network neighborhood for query Sequence : RFFL_HUMAN

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RFFL_HUMAN
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RFFL_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	175	Target Neighborhood Hits	175	Shared Neighborhood Hits	175
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	0 (rank : 2)	NC score	0.981856 (rank : 2)
Query Neighborhood Hits	175	Target Neighborhood Hits	145	Shared Neighborhood Hits	123
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_HUMAN
θ value	2.92676e-75 (rank : 3)	NC score	0.926200 (rank : 3)
Query Neighborhood Hits	175	Target Neighborhood Hits	153	Shared Neighborhood Hits	105
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	2.73936e-73 (rank : 4)	NC score	0.925967 (rank : 4)
Query Neighborhood Hits	175	Target Neighborhood Hits	160	Shared Neighborhood Hits	107
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

BIRC2_HUMAN
θ value	4.76016e-09 (rank : 5)	NC score	0.462711 (rank : 9)
Query Neighborhood Hits	175	Target Neighborhood Hits	142	Shared Neighborhood Hits	74
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC2_MOUSE
θ value	1.38499e-08 (rank : 6)	NC score	0.461487 (rank : 10)
Query Neighborhood Hits	175	Target Neighborhood Hits	137	Shared Neighborhood Hits	73
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_HUMAN
θ value	1.80886e-08 (rank : 7)	NC score	0.465416 (rank : 8)
Query Neighborhood Hits	175	Target Neighborhood Hits	133	Shared Neighborhood Hits	77
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC3_MOUSE
θ value	1.80886e-08 (rank : 8)	NC score	0.468363 (rank : 7)
Query Neighborhood Hits	175	Target Neighborhood Hits	113	Shared Neighborhood Hits	76
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC4_HUMAN
θ value	3.08544e-08 (rank : 9)	NC score	0.452716 (rank : 11)
Query Neighborhood Hits	175	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	3.08544e-08 (rank : 10)	NC score	0.450760 (rank : 12)
Query Neighborhood Hits	175	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC8_HUMAN
θ value	3.08544e-08 (rank : 11)	NC score	0.511446 (rank : 5)
Query Neighborhood Hits	175	Target Neighborhood Hits	121	Shared Neighborhood Hits	69
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC7_HUMAN
θ value	3.77169e-06 (rank : 12)	NC score	0.484402 (rank : 6)
Query Neighborhood Hits	175	Target Neighborhood Hits	185	Shared Neighborhood Hits	82
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

MYLIP_HUMAN
θ value	8.40245e-06 (rank : 13)	NC score	0.277191 (rank : 21)
Query Neighborhood Hits	175	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MIB1_HUMAN
θ value	1.43324e-05 (rank : 14)	NC score	0.195892 (rank : 32)
Query Neighborhood Hits	175	Target Neighborhood Hits	470	Shared Neighborhood Hits	76
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	1.43324e-05 (rank : 15)	NC score	0.196824 (rank : 31)
Query Neighborhood Hits	175	Target Neighborhood Hits	471	Shared Neighborhood Hits	76
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

LRSM1_MOUSE
θ value	2.44474e-05 (rank : 16)	NC score	0.219810 (rank : 23)
Query Neighborhood Hits	175	Target Neighborhood Hits	874	Shared Neighborhood Hits	79
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MYLIP_MOUSE
θ value	2.44474e-05 (rank : 17)	NC score	0.248285 (rank : 22)
Query Neighborhood Hits	175	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NEURL_MOUSE
θ value	2.44474e-05 (rank : 18)	NC score	0.411612 (rank : 14)
Query Neighborhood Hits	175	Target Neighborhood Hits	106	Shared Neighborhood Hits	70
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

LRSM1_HUMAN
θ value	3.19293e-05 (rank : 19)	NC score	0.201230 (rank : 29)
Query Neighborhood Hits	175	Target Neighborhood Hits	1078	Shared Neighborhood Hits	79
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

NEUL1_HUMAN
θ value	3.19293e-05 (rank : 20)	NC score	0.408715 (rank : 17)
Query Neighborhood Hits	175	Target Neighborhood Hits	114	Shared Neighborhood Hits	71
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

MIB2_MOUSE
θ value	9.29e-05 (rank : 21)	NC score	0.178165 (rank : 38)
Query Neighborhood Hits	175	Target Neighborhood Hits	409	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

CGRF1_HUMAN
θ value	0.000158464 (rank : 22)	NC score	0.419365 (rank : 13)
Query Neighborhood Hits	175	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

MIB2_HUMAN
θ value	0.000270298 (rank : 23)	NC score	0.179701 (rank : 37)
Query Neighborhood Hits	175	Target Neighborhood Hits	438	Shared Neighborhood Hits	63
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

RKHD1_HUMAN
θ value	0.00035302 (rank : 24)	NC score	0.411443 (rank : 15)
Query Neighborhood Hits	175	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

CGRF1_MOUSE
θ value	0.000461057 (rank : 25)	NC score	0.399181 (rank : 18)
Query Neighborhood Hits	175	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

PCQAP_HUMAN
θ value	0.000786445 (rank : 26)	NC score	0.096139 (rank : 112)
Query Neighborhood Hits	175	Target Neighborhood Hits	549	Shared Neighborhood Hits	17
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

MGRN1_HUMAN
θ value	0.00102713 (rank : 27)	NC score	0.335368 (rank : 20)
Query Neighborhood Hits	175	Target Neighborhood Hits	192	Shared Neighborhood Hits	64
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

ZFY21_MOUSE
θ value	0.00102713 (rank : 28)	NC score	0.217408 (rank : 24)
Query Neighborhood Hits	175	Target Neighborhood Hits	72	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

MGRN1_MOUSE
θ value	0.00175202 (rank : 29)	NC score	0.337788 (rank : 19)
Query Neighborhood Hits	175	Target Neighborhood Hits	149	Shared Neighborhood Hits	61
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

RNF8_HUMAN
θ value	0.00390308 (rank : 30)	NC score	0.208942 (rank : 27)
Query Neighborhood Hits	175	Target Neighborhood Hits	622	Shared Neighborhood Hits	86
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

HGS_HUMAN
θ value	0.00665767 (rank : 31)	NC score	0.154440 (rank : 51)
Query Neighborhood Hits	175	Target Neighborhood Hits	517	Shared Neighborhood Hits	49
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	0.00869519 (rank : 32)	NC score	0.152456 (rank : 54)
Query Neighborhood Hits	175	Target Neighborhood Hits	589	Shared Neighborhood Hits	45
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

ZFY21_HUMAN
θ value	0.00869519 (rank : 33)	NC score	0.209127 (rank : 25)
Query Neighborhood Hits	175	Target Neighborhood Hits	72	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

MORC4_MOUSE
θ value	0.0113563 (rank : 34)	NC score	0.048779 (rank : 224)
Query Neighborhood Hits	175	Target Neighborhood Hits	235	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BMD7, Q4KMM6, Q8BX95, Q9CS96	Gene names	Morc4, Zcwcc2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

RNF26_HUMAN
θ value	0.0148317 (rank : 35)	NC score	0.409218 (rank : 16)
Query Neighborhood Hits	175	Target Neighborhood Hits	95	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

RO52_HUMAN
θ value	0.0148317 (rank : 36)	NC score	0.137322 (rank : 64)
Query Neighborhood Hits	175	Target Neighborhood Hits	419	Shared Neighborhood Hits	82
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

RN123_HUMAN
θ value	0.0193708 (rank : 37)	NC score	0.152449 (rank : 55)
Query Neighborhood Hits	175	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

ZFY28_HUMAN
θ value	0.0193708 (rank : 38)	NC score	0.209064 (rank : 26)
Query Neighborhood Hits	175	Target Neighborhood Hits	152	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

ZFYV9_HUMAN
θ value	0.0193708 (rank : 39)	NC score	0.172148 (rank : 45)
Query Neighborhood Hits	175	Target Neighborhood Hits	134	Shared Neighborhood Hits	31
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

PCLO_MOUSE
θ value	0.0252991 (rank : 40)	NC score	0.043497 (rank : 228)
Query Neighborhood Hits	175	Target Neighborhood Hits	2275	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

CUTL2_HUMAN
θ value	0.0330416 (rank : 41)	NC score	0.047319 (rank : 226)
Query Neighborhood Hits	175	Target Neighborhood Hits	906	Shared Neighborhood Hits	23
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

MDM4_HUMAN
θ value	0.0431538 (rank : 42)	NC score	0.207436 (rank : 28)
Query Neighborhood Hits	175	Target Neighborhood Hits	37	Shared Neighborhood Hits	24
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

RN123_MOUSE
θ value	0.0431538 (rank : 43)	NC score	0.152365 (rank : 56)
Query Neighborhood Hits	175	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

ZFY16_MOUSE
θ value	0.0431538 (rank : 44)	NC score	0.175987 (rank : 40)
Query Neighborhood Hits	175	Target Neighborhood Hits	108	Shared Neighborhood Hits	32
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

ZFY16_HUMAN
θ value	0.0563607 (rank : 45)	NC score	0.174657 (rank : 43)
Query Neighborhood Hits	175	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

MDM2_MOUSE
θ value	0.0736092 (rank : 46)	NC score	0.180397 (rank : 36)
Query Neighborhood Hits	175	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

RO52_MOUSE
θ value	0.0961366 (rank : 47)	NC score	0.127976 (rank : 75)
Query Neighborhood Hits	175	Target Neighborhood Hits	360	Shared Neighborhood Hits	76
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

TRI35_HUMAN
θ value	0.0961366 (rank : 48)	NC score	0.132659 (rank : 70)
Query Neighborhood Hits	175	Target Neighborhood Hits	382	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

DEN1A_HUMAN
θ value	0.125558 (rank : 49)	NC score	0.033869 (rank : 235)
Query Neighborhood Hits	175	Target Neighborhood Hits	176	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

GOGB1_HUMAN
θ value	0.163984 (rank : 50)	NC score	0.028684 (rank : 240)
Query Neighborhood Hits	175	Target Neighborhood Hits	2297	Shared Neighborhood Hits	53
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

RN185_HUMAN
θ value	0.163984 (rank : 51)	NC score	0.198546 (rank : 30)
Query Neighborhood Hits	175	Target Neighborhood Hits	213	Shared Neighborhood Hits	68
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

CBLB_HUMAN
θ value	0.21417 (rank : 52)	NC score	0.174847 (rank : 42)
Query Neighborhood Hits	175	Target Neighborhood Hits	261	Shared Neighborhood Hits	76
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBLB_MOUSE
θ value	0.21417 (rank : 53)	NC score	0.175255 (rank : 41)
Query Neighborhood Hits	175	Target Neighborhood Hits	277	Shared Neighborhood Hits	76
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBL_HUMAN
θ value	0.21417 (rank : 54)	NC score	0.176087 (rank : 39)
Query Neighborhood Hits	175	Target Neighborhood Hits	353	Shared Neighborhood Hits	80
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
θ value	0.21417 (rank : 55)	NC score	0.173605 (rank : 44)
Query Neighborhood Hits	175	Target Neighborhood Hits	426	Shared Neighborhood Hits	83
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

IQEC3_HUMAN
θ value	0.21417 (rank : 56)	NC score	0.023313 (rank : 246)
Query Neighborhood Hits	175	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

TRI35_MOUSE
θ value	0.21417 (rank : 57)	NC score	0.133345 (rank : 69)
Query Neighborhood Hits	175	Target Neighborhood Hits	465	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

CHFR_HUMAN
θ value	0.279714 (rank : 58)	NC score	0.139522 (rank : 63)
Query Neighborhood Hits	175	Target Neighborhood Hits	255	Shared Neighborhood Hits	58
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

CUTL2_MOUSE
θ value	0.279714 (rank : 59)	NC score	0.043548 (rank : 227)
Query Neighborhood Hits	175	Target Neighborhood Hits	771	Shared Neighborhood Hits	15
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

EEA1_MOUSE
θ value	0.279714 (rank : 60)	NC score	0.061008 (rank : 192)
Query Neighborhood Hits	175	Target Neighborhood Hits	1637	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

MDM2_HUMAN
θ value	0.279714 (rank : 61)	NC score	0.191739 (rank : 33)
Query Neighborhood Hits	175	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

PCQAP_MOUSE
θ value	0.279714 (rank : 62)	NC score	0.089901 (rank : 119)
Query Neighborhood Hits	175	Target Neighborhood Hits	506	Shared Neighborhood Hits	21
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PRR11_MOUSE
θ value	0.279714 (rank : 63)	NC score	0.049393 (rank : 223)
Query Neighborhood Hits	175	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BHE0, Q3V3H1	Gene names	Prr11
Domain Architecture	No domain graphic available
Description	Proline-rich protein 11.

RUFY1_MOUSE
θ value	0.279714 (rank : 64)	NC score	0.108591 (rank : 87)
Query Neighborhood Hits	175	Target Neighborhood Hits	765	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

TRI31_HUMAN
θ value	0.279714 (rank : 65)	NC score	0.140551 (rank : 61)
Query Neighborhood Hits	175	Target Neighborhood Hits	299	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

RUFY2_HUMAN
θ value	0.365318 (rank : 66)	NC score	0.089498 (rank : 120)
Query Neighborhood Hits	175	Target Neighborhood Hits	1208	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

RUFY2_MOUSE
θ value	0.365318 (rank : 67)	NC score	0.107195 (rank : 92)
Query Neighborhood Hits	175	Target Neighborhood Hits	820	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

CHFR_MOUSE
θ value	0.47712 (rank : 68)	NC score	0.141392 (rank : 60)
Query Neighborhood Hits	175	Target Neighborhood Hits	264	Shared Neighborhood Hits	63
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

EEA1_HUMAN
θ value	0.47712 (rank : 69)	NC score	0.060950 (rank : 194)
Query Neighborhood Hits	175	Target Neighborhood Hits	1796	Shared Neighborhood Hits	63
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

PI51C_HUMAN
θ value	0.47712 (rank : 70)	NC score	0.027346 (rank : 243)
Query Neighborhood Hits	175	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

RN168_HUMAN
θ value	0.47712 (rank : 71)	NC score	0.162927 (rank : 47)
Query Neighborhood Hits	175	Target Neighborhood Hits	370	Shared Neighborhood Hits	75
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN185_MOUSE
θ value	0.47712 (rank : 72)	NC score	0.191293 (rank : 34)
Query Neighborhood Hits	175	Target Neighborhood Hits	211	Shared Neighborhood Hits	68
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RUFY1_HUMAN
θ value	0.47712 (rank : 73)	NC score	0.108441 (rank : 88)
Query Neighborhood Hits	175	Target Neighborhood Hits	848	Shared Neighborhood Hits	47
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

TRI26_MOUSE
θ value	0.47712 (rank : 74)	NC score	0.151508 (rank : 58)
Query Neighborhood Hits	175	Target Neighborhood Hits	339	Shared Neighborhood Hits	81
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

RNF8_MOUSE
θ value	0.62314 (rank : 75)	NC score	0.185515 (rank : 35)
Query Neighborhood Hits	175	Target Neighborhood Hits	618	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

TRI11_HUMAN
θ value	0.62314 (rank : 76)	NC score	0.105749 (rank : 93)
Query Neighborhood Hits	175	Target Neighborhood Hits	316	Shared Neighborhood Hits	73
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI11_MOUSE
θ value	0.62314 (rank : 77)	NC score	0.107250 (rank : 91)
Query Neighborhood Hits	175	Target Neighborhood Hits	329	Shared Neighborhood Hits	75
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI26_HUMAN
θ value	0.62314 (rank : 78)	NC score	0.148998 (rank : 59)
Query Neighborhood Hits	175	Target Neighborhood Hits	335	Shared Neighborhood Hits	80
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI50_MOUSE
θ value	0.62314 (rank : 79)	NC score	0.124761 (rank : 76)
Query Neighborhood Hits	175	Target Neighborhood Hits	326	Shared Neighborhood Hits	81
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

UBP34_HUMAN
θ value	0.62314 (rank : 80)	NC score	0.037353 (rank : 231)
Query Neighborhood Hits	175	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

WDFY3_HUMAN
θ value	0.62314 (rank : 81)	NC score	0.098041 (rank : 106)
Query Neighborhood Hits	175	Target Neighborhood Hits	348	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
θ value	0.62314 (rank : 82)	NC score	0.097991 (rank : 107)
Query Neighborhood Hits	175	Target Neighborhood Hits	332	Shared Neighborhood Hits	34
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

RN169_HUMAN
θ value	0.813845 (rank : 83)	NC score	0.131179 (rank : 71)
Query Neighborhood Hits	175	Target Neighborhood Hits	203	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

TRI39_HUMAN
θ value	0.813845 (rank : 84)	NC score	0.104881 (rank : 94)
Query Neighborhood Hits	175	Target Neighborhood Hits	693	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI39_MOUSE
θ value	0.813845 (rank : 85)	NC score	0.104119 (rank : 96)
Query Neighborhood Hits	175	Target Neighborhood Hits	691	Shared Neighborhood Hits	76
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

ZFYV1_HUMAN
θ value	0.813845 (rank : 86)	NC score	0.130165 (rank : 72)
Query Neighborhood Hits	175	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

BTBD7_HUMAN
θ value	1.06291 (rank : 87)	NC score	0.034850 (rank : 232)
Query Neighborhood Hits	175	Target Neighborhood Hits	176	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P203, Q69Z05, Q7Z308, Q86TS0, Q9HAA4, Q9NVM0	Gene names	BTBD7, KIAA1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

MYRIP_HUMAN
θ value	1.06291 (rank : 88)	NC score	0.033053 (rank : 237)
Query Neighborhood Hits	175	Target Neighborhood Hits	269	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

PO6F2_MOUSE
θ value	1.06291 (rank : 89)	NC score	0.019741 (rank : 256)
Query Neighborhood Hits	175	Target Neighborhood Hits	639	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PRRX2_MOUSE
θ value	1.06291 (rank : 90)	NC score	0.009111 (rank : 269)
Query Neighborhood Hits	175	Target Neighborhood Hits	351	Shared Neighborhood Hits	6
SwissProt Accessions	Q06348, Q61651	Gene names	Prrx2, Prx2, S8
Domain Architecture
Description	Paired mesoderm homeobox protein 2 (PRX-2) (Homeobox protein S8).

RNF5_HUMAN
θ value	1.06291 (rank : 91)	NC score	0.158561 (rank : 49)
Query Neighborhood Hits	175	Target Neighborhood Hits	206	Shared Neighborhood Hits	68
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

TIRAP_MOUSE
θ value	1.06291 (rank : 92)	NC score	0.034486 (rank : 234)
Query Neighborhood Hits	175	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JY1, Q91ZW0	Gene names	Tirap, Mal
Domain Architecture
Description	Toll-interleukin 1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (MyD88 adapter-like protein) (Adaptor protein Wyatt).

TRI12_MOUSE
θ value	1.06291 (rank : 93)	NC score	0.118420 (rank : 77)
Query Neighborhood Hits	175	Target Neighborhood Hits	387	Shared Neighborhood Hits	72
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

ZFY27_HUMAN
θ value	1.06291 (rank : 94)	NC score	0.152663 (rank : 53)
Query Neighborhood Hits	175	Target Neighborhood Hits	64	Shared Neighborhood Hits	32
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFY27_MOUSE
θ value	1.06291 (rank : 95)	NC score	0.152097 (rank : 57)
Query Neighborhood Hits	175	Target Neighborhood Hits	53	Shared Neighborhood Hits	32
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

ZFYV1_MOUSE
θ value	1.06291 (rank : 96)	NC score	0.129326 (rank : 73)
Query Neighborhood Hits	175	Target Neighborhood Hits	153	Shared Neighborhood Hits	32
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

ARI1A_HUMAN
θ value	1.38821 (rank : 97)	NC score	0.021966 (rank : 252)
Query Neighborhood Hits	175	Target Neighborhood Hits	787	Shared Neighborhood Hits	16
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

RN168_MOUSE
θ value	1.38821 (rank : 98)	NC score	0.140551 (rank : 62)
Query Neighborhood Hits	175	Target Neighborhood Hits	440	Shared Neighborhood Hits	78
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RNF5_MOUSE
θ value	1.38821 (rank : 99)	NC score	0.154841 (rank : 50)
Query Neighborhood Hits	175	Target Neighborhood Hits	206	Shared Neighborhood Hits	68
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

SIAH2_HUMAN
θ value	1.38821 (rank : 100)	NC score	0.135994 (rank : 67)
Query Neighborhood Hits	175	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

SIAH2_MOUSE
θ value	1.38821 (rank : 101)	NC score	0.136602 (rank : 65)
Query Neighborhood Hits	175	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

TRI27_MOUSE
θ value	1.38821 (rank : 102)	NC score	0.103583 (rank : 98)
Query Neighborhood Hits	175	Target Neighborhood Hits	261	Shared Neighborhood Hits	76
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

MINT_HUMAN
θ value	1.81305 (rank : 103)	NC score	0.017639 (rank : 258)
Query Neighborhood Hits	175	Target Neighborhood Hits	1291	Shared Neighborhood Hits	23
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

RNF13_HUMAN
θ value	1.81305 (rank : 104)	NC score	0.068717 (rank : 171)
Query Neighborhood Hits	175	Target Neighborhood Hits	147	Shared Neighborhood Hits	28
SwissProt Accessions	O43567	Gene names	RNF13, RZF
Domain Architecture
Description	RING finger protein 13.

SETD8_HUMAN
θ value	1.81305 (rank : 105)	NC score	0.020346 (rank : 254)
Query Neighborhood Hits	175	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQR1, Q86W83, Q8TD09	Gene names	SETD8, PRSET7, SET07, SET8
Domain Architecture
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7).

UBP34_MOUSE
θ value	1.81305 (rank : 106)	NC score	0.031885 (rank : 238)
Query Neighborhood Hits	175	Target Neighborhood Hits	189	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

BRCA1_MOUSE
θ value	2.36792 (rank : 107)	NC score	0.086838 (rank : 124)
Query Neighborhood Hits	175	Target Neighborhood Hits	436	Shared Neighborhood Hits	72
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

CBLC_HUMAN
θ value	2.36792 (rank : 108)	NC score	0.164257 (rank : 46)
Query Neighborhood Hits	175	Target Neighborhood Hits	173	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

FGD3_MOUSE
θ value	2.36792 (rank : 109)	NC score	0.048043 (rank : 225)
Query Neighborhood Hits	175	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD5_MOUSE
θ value	2.36792 (rank : 110)	NC score	0.077786 (rank : 150)
Query Neighborhood Hits	175	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

MTMR3_HUMAN
θ value	2.36792 (rank : 111)	NC score	0.081132 (rank : 138)
Query Neighborhood Hits	175	Target Neighborhood Hits	163	Shared Neighborhood Hits	33
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

NCOR1_HUMAN
θ value	2.36792 (rank : 112)	NC score	0.017588 (rank : 259)
Query Neighborhood Hits	175	Target Neighborhood Hits	577	Shared Neighborhood Hits	16
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

PCLO_HUMAN
θ value	2.36792 (rank : 113)	NC score	0.033557 (rank : 236)
Query Neighborhood Hits	175	Target Neighborhood Hits	2046	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

PEX10_HUMAN
θ value	2.36792 (rank : 114)	NC score	0.162284 (rank : 48)
Query Neighborhood Hits	175	Target Neighborhood Hits	255	Shared Neighborhood Hits	73
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

SPEG_HUMAN
θ value	2.36792 (rank : 115)	NC score	-0.001918 (rank : 278)
Query Neighborhood Hits	175	Target Neighborhood Hits	1762	Shared Neighborhood Hits	13
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

T22D2_HUMAN
θ value	2.36792 (rank : 116)	NC score	0.023109 (rank : 247)
Query Neighborhood Hits	175	Target Neighborhood Hits	250	Shared Neighborhood Hits	8
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TRI40_HUMAN
θ value	2.36792 (rank : 117)	NC score	0.134904 (rank : 68)
Query Neighborhood Hits	175	Target Neighborhood Hits	279	Shared Neighborhood Hits	67
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

AMFR2_HUMAN
θ value	3.0926 (rank : 118)	NC score	0.087210 (rank : 123)
Query Neighborhood Hits	175	Target Neighborhood Hits	219	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

AMFR_MOUSE
θ value	3.0926 (rank : 119)	NC score	0.086085 (rank : 127)
Query Neighborhood Hits	175	Target Neighborhood Hits	208	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R049, Q8K008, Q99LH5	Gene names	Amfr
Domain Architecture
Description	Autocrine motility factor receptor (EC 6.3.2.19) (AMF receptor).

BTBD7_MOUSE
θ value	3.0926 (rank : 120)	NC score	0.034530 (rank : 233)
Query Neighborhood Hits	175	Target Neighborhood Hits	228	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

FGD5_HUMAN
θ value	3.0926 (rank : 121)	NC score	0.075547 (rank : 158)
Query Neighborhood Hits	175	Target Neighborhood Hits	235	Shared Neighborhood Hits	32
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

LPIN2_MOUSE
θ value	3.0926 (rank : 122)	NC score	0.022867 (rank : 249)
Query Neighborhood Hits	175	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PI5, Q8C357, Q8C7I8, Q8CC85, Q8CHR7	Gene names	Lpin2
Domain Architecture
Description	Lipin-2.

NPAS2_HUMAN
θ value	3.0926 (rank : 123)	NC score	0.011680 (rank : 263)
Query Neighborhood Hits	175	Target Neighborhood Hits	150	Shared Neighborhood Hits	8
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

PO6F2_HUMAN
θ value	3.0926 (rank : 124)	NC score	0.017910 (rank : 257)
Query Neighborhood Hits	175	Target Neighborhood Hits	618	Shared Neighborhood Hits	14
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

RFWD2_HUMAN
θ value	3.0926 (rank : 125)	NC score	0.077563 (rank : 153)
Query Neighborhood Hits	175	Target Neighborhood Hits	518	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

RFWD2_MOUSE
θ value	3.0926 (rank : 126)	NC score	0.080563 (rank : 140)
Query Neighborhood Hits	175	Target Neighborhood Hits	535	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RN183_HUMAN
θ value	3.0926 (rank : 127)	NC score	0.063434 (rank : 185)
Query Neighborhood Hits	175	Target Neighborhood Hits	126	Shared Neighborhood Hits	31
SwissProt Accessions	Q96D59	Gene names	RNF183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

TRI60_HUMAN
θ value	3.0926 (rank : 128)	NC score	0.104111 (rank : 97)
Query Neighborhood Hits	175	Target Neighborhood Hits	357	Shared Neighborhood Hits	76
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

ANFY1_HUMAN
θ value	4.03905 (rank : 129)	NC score	0.070382 (rank : 170)
Query Neighborhood Hits	175	Target Neighborhood Hits	480	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_MOUSE
θ value	4.03905 (rank : 130)	NC score	0.072833 (rank : 163)
Query Neighborhood Hits	175	Target Neighborhood Hits	480	Shared Neighborhood Hits	39
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANK3_HUMAN
θ value	4.03905 (rank : 131)	NC score	0.028789 (rank : 239)
Query Neighborhood Hits	175	Target Neighborhood Hits	853	Shared Neighborhood Hits	20
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

FBN3_HUMAN
θ value	4.03905 (rank : 132)	NC score	0.004568 (rank : 271)
Query Neighborhood Hits	175	Target Neighborhood Hits	543	Shared Neighborhood Hits	4
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

LPIN3_HUMAN
θ value	4.03905 (rank : 133)	NC score	0.022366 (rank : 250)
Query Neighborhood Hits	175	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

MAGAA_HUMAN
θ value	4.03905 (rank : 134)	NC score	0.009115 (rank : 268)
Query Neighborhood Hits	175	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	P43363	Gene names	MAGEA10, MAGE10
Domain Architecture
Description	Melanoma-associated antigen 10 (MAGE-10 antigen).

NCOA6_MOUSE
θ value	4.03905 (rank : 135)	NC score	0.027641 (rank : 242)
Query Neighborhood Hits	175	Target Neighborhood Hits	1076	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PI51C_MOUSE
θ value	4.03905 (rank : 136)	NC score	0.022023 (rank : 251)
Query Neighborhood Hits	175	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

SIA1A_MOUSE
θ value	4.03905 (rank : 137)	NC score	0.112354 (rank : 84)
Query Neighborhood Hits	175	Target Neighborhood Hits	72	Shared Neighborhood Hits	33
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIA1B_MOUSE
θ value	4.03905 (rank : 138)	NC score	0.113184 (rank : 80)
Query Neighborhood Hits	175	Target Neighborhood Hits	69	Shared Neighborhood Hits	33
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

SIAH1_HUMAN
θ value	4.03905 (rank : 139)	NC score	0.112448 (rank : 83)
Query Neighborhood Hits	175	Target Neighborhood Hits	72	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

SYN3_HUMAN
θ value	4.03905 (rank : 140)	NC score	0.023506 (rank : 245)
Query Neighborhood Hits	175	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

TESK2_MOUSE
θ value	4.03905 (rank : 141)	NC score	-0.003422 (rank : 279)
Query Neighborhood Hits	175	Target Neighborhood Hits	833	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

TRI27_HUMAN
θ value	4.03905 (rank : 142)	NC score	0.095005 (rank : 116)
Query Neighborhood Hits	175	Target Neighborhood Hits	273	Shared Neighborhood Hits	72
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

ZN687_MOUSE
θ value	4.03905 (rank : 143)	NC score	0.002252 (rank : 277)
Query Neighborhood Hits	175	Target Neighborhood Hits	913	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

BFAR_MOUSE
θ value	5.27518 (rank : 144)	NC score	0.104131 (rank : 95)
Query Neighborhood Hits	175	Target Neighborhood Hits	232	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

CP250_MOUSE
θ value	5.27518 (rank : 145)	NC score	0.020797 (rank : 253)
Query Neighborhood Hits	175	Target Neighborhood Hits	1583	Shared Neighborhood Hits	39
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

KI21A_MOUSE
θ value	5.27518 (rank : 146)	NC score	0.010854 (rank : 266)
Query Neighborhood Hits	175	Target Neighborhood Hits	1317	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

RN183_MOUSE
θ value	5.27518 (rank : 147)	NC score	0.055273 (rank : 213)
Query Neighborhood Hits	175	Target Neighborhood Hits	119	Shared Neighborhood Hits	28
SwissProt Accessions	Q8QZS5, Q5NBV8	Gene names	Rnf183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

RNF13_MOUSE
θ value	5.27518 (rank : 148)	NC score	0.054598 (rank : 214)
Query Neighborhood Hits	175	Target Neighborhood Hits	164	Shared Neighborhood Hits	29
SwissProt Accessions	O54965, O54966	Gene names	Rnf13, Rzf
Domain Architecture
Description	RING finger protein 13.

SIN3B_MOUSE
θ value	5.27518 (rank : 149)	NC score	0.011464 (rank : 264)
Query Neighborhood Hits	175	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q62141, O54976, Q6A013, Q8VCB8, Q8VDZ5	Gene names	Sin3b, Kiaa0700
Domain Architecture
Description	Paired amphipathic helix protein Sin3b (Transcriptional corepressor Sin3b) (Histone deacetylase complex subunit Sin3b).

SYN3_MOUSE
θ value	5.27518 (rank : 150)	NC score	0.022998 (rank : 248)
Query Neighborhood Hits	175	Target Neighborhood Hits	200	Shared Neighborhood Hits	10
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

TRI17_MOUSE
θ value	5.27518 (rank : 151)	NC score	0.098123 (rank : 104)
Query Neighborhood Hits	175	Target Neighborhood Hits	620	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

TRI25_HUMAN
θ value	5.27518 (rank : 152)	NC score	0.077952 (rank : 149)
Query Neighborhood Hits	175	Target Neighborhood Hits	472	Shared Neighborhood Hits	70
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

ANR15_HUMAN
θ value	6.88961 (rank : 153)	NC score	0.028649 (rank : 241)
Query Neighborhood Hits	175	Target Neighborhood Hits	478	Shared Neighborhood Hits	17
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

B3A3_HUMAN
θ value	6.88961 (rank : 154)	NC score	0.005544 (rank : 270)
Query Neighborhood Hits	175	Target Neighborhood Hits	119	Shared Neighborhood Hits	4
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

CBLC_MOUSE
θ value	6.88961 (rank : 155)	NC score	0.153289 (rank : 52)
Query Neighborhood Hits	175	Target Neighborhood Hits	186	Shared Neighborhood Hits	69
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

FRAS1_MOUSE
θ value	6.88961 (rank : 156)	NC score	0.002856 (rank : 275)
Query Neighborhood Hits	175	Target Neighborhood Hits	747	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

LPIN2_HUMAN
θ value	6.88961 (rank : 157)	NC score	0.020290 (rank : 255)
Query Neighborhood Hits	175	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q92539	Gene names	LPIN2, KIAA0249
Domain Architecture	No domain graphic available
Description	Lipin-2.

MAGI1_MOUSE
θ value	6.88961 (rank : 158)	NC score	0.004541 (rank : 272)
Query Neighborhood Hits	175	Target Neighborhood Hits	403	Shared Neighborhood Hits	5
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

NEUM_HUMAN
θ value	6.88961 (rank : 159)	NC score	0.015708 (rank : 261)
Query Neighborhood Hits	175	Target Neighborhood Hits	132	Shared Neighborhood Hits	5
SwissProt Accessions	P17677	Gene names	GAP43
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (PP46) (Neural phosphoprotein B-50).

TRI50_HUMAN
θ value	6.88961 (rank : 160)	NC score	0.108173 (rank : 90)
Query Neighborhood Hits	175	Target Neighborhood Hits	294	Shared Neighborhood Hits	77
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRIM4_HUMAN
θ value	6.88961 (rank : 161)	NC score	0.102498 (rank : 99)
Query Neighborhood Hits	175	Target Neighborhood Hits	321	Shared Neighborhood Hits	72
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

ZN287_MOUSE
θ value	6.88961 (rank : 162)	NC score	-0.005133 (rank : 280)
Query Neighborhood Hits	175	Target Neighborhood Hits	771	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQB9	Gene names	Znf287, Skat2, Zfp287
Domain Architecture
Description	Zinc finger protein 287 (Zfp-287) (Zinc finger protein SKAT-2).

ANR41_HUMAN
θ value	8.99809 (rank : 163)	NC score	0.025625 (rank : 244)
Query Neighborhood Hits	175	Target Neighborhood Hits	332	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

BRMS1_HUMAN
θ value	8.99809 (rank : 164)	NC score	0.016495 (rank : 260)
Query Neighborhood Hits	175	Target Neighborhood Hits	60	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCU9	Gene names	BRMS1
Domain Architecture	No domain graphic available
Description	Breast cancer metastasis-suppressor 1.

CABYR_MOUSE
θ value	8.99809 (rank : 165)	NC score	0.013115 (rank : 262)
Query Neighborhood Hits	175	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D424, Q91Y41, Q91Y42	Gene names	Cabyr, Cbp86
Domain Architecture	No domain graphic available
Description	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium- binding protein 86) (Testis-specific calcium-binding protein CBP86).

FGD3_HUMAN
θ value	8.99809 (rank : 166)	NC score	0.057568 (rank : 205)
Query Neighborhood Hits	175	Target Neighborhood Hits	249	Shared Neighborhood Hits	31
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

HSP74_HUMAN
θ value	8.99809 (rank : 167)	NC score	0.004273 (rank : 273)
Query Neighborhood Hits	175	Target Neighborhood Hits	154	Shared Neighborhood Hits	8
SwissProt Accessions	P34932, O95756	Gene names	HSPA4
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2) (HSP70RY).

KCNN3_MOUSE
θ value	8.99809 (rank : 168)	NC score	0.010471 (rank : 267)
Query Neighborhood Hits	175	Target Neighborhood Hits	171	Shared Neighborhood Hits	10
SwissProt Accessions	P58391	Gene names	Kcnn3, Sk3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3).

RXRB_HUMAN
θ value	8.99809 (rank : 169)	NC score	0.002642 (rank : 276)
Query Neighborhood Hits	175	Target Neighborhood Hits	280	Shared Neighborhood Hits	7
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

RXRB_MOUSE
θ value	8.99809 (rank : 170)	NC score	0.002968 (rank : 274)
Query Neighborhood Hits	175	Target Neighborhood Hits	230	Shared Neighborhood Hits	8
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

TRAF7_HUMAN
θ value	8.99809 (rank : 171)	NC score	0.041669 (rank : 230)
Query Neighborhood Hits	175	Target Neighborhood Hits	482	Shared Neighborhood Hits	64
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

TRAF7_MOUSE
θ value	8.99809 (rank : 172)	NC score	0.042782 (rank : 229)
Query Neighborhood Hits	175	Target Neighborhood Hits	470	Shared Neighborhood Hits	63
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TRI17_HUMAN
θ value	8.99809 (rank : 173)	NC score	0.096159 (rank : 111)
Query Neighborhood Hits	175	Target Neighborhood Hits	318	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRIM5_HUMAN
θ value	8.99809 (rank : 174)	NC score	0.096105 (rank : 113)
Query Neighborhood Hits	175	Target Neighborhood Hits	424	Shared Neighborhood Hits	76
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

WASIP_HUMAN
θ value	8.99809 (rank : 175)	NC score	0.011328 (rank : 265)
Query Neighborhood Hits	175	Target Neighborhood Hits	458	Shared Neighborhood Hits	9
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

BFAR_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.100069 (rank : 101)
Query Neighborhood Hits	175	Target Neighborhood Hits	222	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BIR1A_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.110027 (rank : 86)
Query Neighborhood Hits	175	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1B_MOUSE
θ value	θ > 10 (rank : 178)	NC score	0.111793 (rank : 85)
Query Neighborhood Hits	175	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1E_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.113212 (rank : 79)
Query Neighborhood Hits	175	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
θ value	θ > 10 (rank : 180)	NC score	0.112659 (rank : 81)
Query Neighborhood Hits	175	Target Neighborhood Hits	88	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.112601 (rank : 82)
Query Neighborhood Hits	175	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIRC1_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.113645 (rank : 78)
Query Neighborhood Hits	175	Target Neighborhood Hits	61	Shared Neighborhood Hits	9
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIRC5_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.128608 (rank : 74)
Query Neighborhood Hits	175	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.136551 (rank : 66)
Query Neighborhood Hits	175	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC6_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.084372 (rank : 129)
Query Neighborhood Hits	175	Target Neighborhood Hits	161	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

BRCA1_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.077676 (rank : 151)
Query Neighborhood Hits	175	Target Neighborhood Hits	381	Shared Neighborhood Hits	66
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

ERMAP_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.050515 (rank : 222)
Query Neighborhood Hits	175	Target Neighborhood Hits	155	Shared Neighborhood Hits	20
SwissProt Accessions	Q96PL5, Q5VV53, Q6DUE0, Q7Z3X0, Q8NCV8, Q8NCW2, Q8NCW3, Q96PL6	Gene names	ERMAP, RD, SC
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor (hERMAP) (Scianna blood group antigen) (Radin blood group antigen).

FGD2_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.052085 (rank : 216)
Query Neighborhood Hits	175	Target Neighborhood Hits	151	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.051823 (rank : 217)
Query Neighborhood Hits	175	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD6_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.058780 (rank : 201)
Query Neighborhood Hits	175	Target Neighborhood Hits	237	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

FGD6_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.060556 (rank : 196)
Query Neighborhood Hits	175	Target Neighborhood Hits	282	Shared Neighborhood Hits	31
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FYV1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.081980 (rank : 133)
Query Neighborhood Hits	175	Target Neighborhood Hits	217	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

FYV1_MOUSE
θ value	θ > 10 (rank : 193)	NC score	0.082369 (rank : 132)
Query Neighborhood Hits	175	Target Neighborhood Hits	191	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

MDM4_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.096815 (rank : 109)
Query Neighborhood Hits	175	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MEFV_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.057260 (rank : 207)
Query Neighborhood Hits	175	Target Neighborhood Hits	431	Shared Neighborhood Hits	27
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MEFV_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.057410 (rank : 206)
Query Neighborhood Hits	175	Target Neighborhood Hits	236	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

PKHF1_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.090102 (rank : 118)
Query Neighborhood Hits	175	Target Neighborhood Hits	76	Shared Neighborhood Hits	27
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PKHF1_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.086622 (rank : 125)
Query Neighborhood Hits	175	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

PKHF2_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.079235 (rank : 143)
Query Neighborhood Hits	175	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.079215 (rank : 144)
Query Neighborhood Hits	175	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

RBNS5_HUMAN
θ value	θ > 10 (rank : 201)	NC score	0.064140 (rank : 182)
Query Neighborhood Hits	175	Target Neighborhood Hits	242	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

RBNS5_MOUSE
θ value	θ > 10 (rank : 202)	NC score	0.063360 (rank : 186)
Query Neighborhood Hits	175	Target Neighborhood Hits	266	Shared Neighborhood Hits	33
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RFPL1_HUMAN
θ value	θ > 10 (rank : 203)	NC score	0.055626 (rank : 212)
Query Neighborhood Hits	175	Target Neighborhood Hits	119	Shared Neighborhood Hits	31
SwissProt Accessions	O75677, Q6IC06	Gene names	RFPL1, RFPL1L, RNF78
Domain Architecture
Description	Ret finger protein-like 1 (RING finger protein 78).

RFPL2_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.060425 (rank : 197)
Query Neighborhood Hits	175	Target Neighborhood Hits	126	Shared Neighborhood Hits	38
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

RFPL3_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.057248 (rank : 208)
Query Neighborhood Hits	175	Target Neighborhood Hits	134	Shared Neighborhood Hits	34
SwissProt Accessions	O75679, Q6IC04	Gene names	RFPL3
Domain Architecture
Description	Ret finger protein-like 3.

RING1_HUMAN
θ value	θ > 10 (rank : 206)	NC score	0.064474 (rank : 181)
Query Neighborhood Hits	175	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

RING1_MOUSE
θ value	θ > 10 (rank : 207)	NC score	0.063203 (rank : 187)
Query Neighborhood Hits	175	Target Neighborhood Hits	220	Shared Neighborhood Hits	53
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

RING2_HUMAN
θ value	θ > 10 (rank : 208)	NC score	0.057862 (rank : 203)
Query Neighborhood Hits	175	Target Neighborhood Hits	201	Shared Neighborhood Hits	50
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
θ value	θ > 10 (rank : 209)	NC score	0.057858 (rank : 204)
Query Neighborhood Hits	175	Target Neighborhood Hits	199	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

RN125_HUMAN
θ value	θ > 10 (rank : 210)	NC score	0.081564 (rank : 135)
Query Neighborhood Hits	175	Target Neighborhood Hits	230	Shared Neighborhood Hits	62
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

RN125_MOUSE
θ value	θ > 10 (rank : 211)	NC score	0.074698 (rank : 161)
Query Neighborhood Hits	175	Target Neighborhood Hits	220	Shared Neighborhood Hits	62
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

RN141_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.098318 (rank : 103)
Query Neighborhood Hits	175	Target Neighborhood Hits	199	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.097411 (rank : 108)
Query Neighborhood Hits	175	Target Neighborhood Hits	200	Shared Neighborhood Hits	54
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN146_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.067350 (rank : 173)
Query Neighborhood Hits	175	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

RN146_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.066393 (rank : 175)
Query Neighborhood Hits	175	Target Neighborhood Hits	161	Shared Neighborhood Hits	52
SwissProt Accessions	Q9CZW6, Q3TF93	Gene names	Rnf146
Domain Architecture	No domain graphic available
Description	RING finger protein 146.

RN166_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.071955 (rank : 165)
Query Neighborhood Hits	175	Target Neighborhood Hits	240	Shared Neighborhood Hits	61
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RN166_MOUSE
θ value	θ > 10 (rank : 217)	NC score	0.071387 (rank : 168)
Query Neighborhood Hits	175	Target Neighborhood Hits	248	Shared Neighborhood Hits	61
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RNF39_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.056921 (rank : 209)
Query Neighborhood Hits	175	Target Neighborhood Hits	200	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

RNF4_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.076435 (rank : 155)
Query Neighborhood Hits	175	Target Neighborhood Hits	212	Shared Neighborhood Hits	61
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RNF4_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.073562 (rank : 162)
Query Neighborhood Hits	175	Target Neighborhood Hits	212	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

SMRA3_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.063771 (rank : 184)
Query Neighborhood Hits	175	Target Neighborhood Hits	265	Shared Neighborhood Hits	62
SwissProt Accessions	Q14527, Q14536, Q16051, Q7KYJ6, Q86YA5, Q92652, Q96KM9	Gene names	SMARCA3, HIP116A, HLTF, SNF2L3, ZBU1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (Helicase-like transcription factor) (HIP116).

SMRA3_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.067509 (rank : 172)
Query Neighborhood Hits	175	Target Neighborhood Hits	267	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PCN7, O35596, O35597, Q80VT6	Gene names	Smarca3, Snf2l3, Zbu1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein) (P113).

TOPRS_HUMAN
θ value	θ > 10 (rank : 223)	NC score	0.080745 (rank : 139)
Query Neighborhood Hits	175	Target Neighborhood Hits	286	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TOPRS_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.084040 (rank : 131)
Query Neighborhood Hits	175	Target Neighborhood Hits	263	Shared Neighborhood Hits	54
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TRI10_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.079183 (rank : 145)
Query Neighborhood Hits	175	Target Neighborhood Hits	315	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRI10_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.075951 (rank : 156)
Query Neighborhood Hits	175	Target Neighborhood Hits	285	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRI13_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.064621 (rank : 179)
Query Neighborhood Hits	175	Target Neighborhood Hits	274	Shared Neighborhood Hits	54
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

TRI13_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.067015 (rank : 174)
Query Neighborhood Hits	175	Target Neighborhood Hits	282	Shared Neighborhood Hits	56
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRI15_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.084647 (rank : 128)
Query Neighborhood Hits	175	Target Neighborhood Hits	395	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

TRI22_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.081490 (rank : 136)
Query Neighborhood Hits	175	Target Neighborhood Hits	396	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRI25_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.080234 (rank : 141)
Query Neighborhood Hits	175	Target Neighborhood Hits	446	Shared Neighborhood Hits	72
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

TRI30_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.084092 (rank : 130)
Query Neighborhood Hits	175	Target Neighborhood Hits	434	Shared Neighborhood Hits	62
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TRI32_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.062141 (rank : 189)
Query Neighborhood Hits	175	Target Neighborhood Hits	264	Shared Neighborhood Hits	54
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.061486 (rank : 191)
Query Neighborhood Hits	175	Target Neighborhood Hits	271	Shared Neighborhood Hits	53
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI34_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.080082 (rank : 142)
Query Neighborhood Hits	175	Target Neighborhood Hits	416	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRI34_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.078676 (rank : 148)
Query Neighborhood Hits	175	Target Neighborhood Hits	332	Shared Neighborhood Hits	55
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRI37_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.064490 (rank : 180)
Query Neighborhood Hits	175	Target Neighborhood Hits	307	Shared Neighborhood Hits	51
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.064760 (rank : 178)
Query Neighborhood Hits	175	Target Neighborhood Hits	316	Shared Neighborhood Hits	52
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRI38_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.075576 (rank : 157)
Query Neighborhood Hits	175	Target Neighborhood Hits	373	Shared Neighborhood Hits	57
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

TRI41_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.077592 (rank : 152)
Query Neighborhood Hits	175	Target Neighborhood Hits	349	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRI43_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.095038 (rank : 115)
Query Neighborhood Hits	175	Target Neighborhood Hits	341	Shared Neighborhood Hits	70
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI47_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.064763 (rank : 177)
Query Neighborhood Hits	175	Target Neighborhood Hits	286	Shared Neighborhood Hits	62
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRI47_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.065700 (rank : 176)
Query Neighborhood Hits	175	Target Neighborhood Hits	295	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRI48_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.078964 (rank : 146)
Query Neighborhood Hits	175	Target Neighborhood Hits	192	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRI49_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.074813 (rank : 159)
Query Neighborhood Hits	175	Target Neighborhood Hits	199	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

TRI52_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.095930 (rank : 114)
Query Neighborhood Hits	175	Target Neighborhood Hits	213	Shared Neighborhood Hits	54
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TRI56_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.056683 (rank : 211)
Query Neighborhood Hits	175	Target Neighborhood Hits	339	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

TRI56_MOUSE
θ value	θ > 10 (rank : 248)	NC score	0.051009 (rank : 221)
Query Neighborhood Hits	175	Target Neighborhood Hits	255	Shared Neighborhood Hits	59
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

TRI59_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.061894 (rank : 190)
Query Neighborhood Hits	175	Target Neighborhood Hits	307	Shared Neighborhood Hits	53
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI59_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.064090 (rank : 183)
Query Neighborhood Hits	175	Target Neighborhood Hits	292	Shared Neighborhood Hits	56
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI60_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.074731 (rank : 160)
Query Neighborhood Hits	175	Target Neighborhood Hits	240	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

TRI62_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.071679 (rank : 166)
Query Neighborhood Hits	175	Target Neighborhood Hits	584	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI62_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.071106 (rank : 169)
Query Neighborhood Hits	175	Target Neighborhood Hits	478	Shared Neighborhood Hits	60
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI63_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.051377 (rank : 220)
Query Neighborhood Hits	175	Target Neighborhood Hits	298	Shared Neighborhood Hits	46
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TRI65_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.088465 (rank : 121)
Query Neighborhood Hits	175	Target Neighborhood Hits	330	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI65_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.098075 (rank : 105)
Query Neighborhood Hits	175	Target Neighborhood Hits	340	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI68_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.078873 (rank : 147)
Query Neighborhood Hits	175	Target Neighborhood Hits	267	Shared Neighborhood Hits	59
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

TRI68_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.086168 (rank : 126)
Query Neighborhood Hits	175	Target Neighborhood Hits	356	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

TRI73_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.108436 (rank : 89)
Query Neighborhood Hits	175	Target Neighborhood Hits	258	Shared Neighborhood Hits	71
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

TRI74_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.100930 (rank : 100)
Query Neighborhood Hits	175	Target Neighborhood Hits	249	Shared Neighborhood Hits	68
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

TRIM2_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.058847 (rank : 200)
Query Neighborhood Hits	175	Target Neighborhood Hits	330	Shared Neighborhood Hits	65
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRIM2_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.058122 (rank : 202)
Query Neighborhood Hits	175	Target Neighborhood Hits	331	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

TRIM3_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.059692 (rank : 199)
Query Neighborhood Hits	175	Target Neighborhood Hits	357	Shared Neighborhood Hits	68
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRIM3_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.056901 (rank : 210)
Query Neighborhood Hits	175	Target Neighborhood Hits	351	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRIM6_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.077291 (rank : 154)
Query Neighborhood Hits	175	Target Neighborhood Hits	412	Shared Neighborhood Hits	58
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

TRIM6_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.081335 (rank : 137)
Query Neighborhood Hits	175	Target Neighborhood Hits	451	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

TRIM7_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.071997 (rank : 164)
Query Neighborhood Hits	175	Target Neighborhood Hits	336	Shared Neighborhood Hits	52
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TRIM7_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.071655 (rank : 167)
Query Neighborhood Hits	175	Target Neighborhood Hits	358	Shared Neighborhood Hits	52
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

TRIM8_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.060829 (rank : 195)
Query Neighborhood Hits	175	Target Neighborhood Hits	650	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM8_MOUSE
θ value	θ > 10 (rank : 270)	NC score	0.061000 (rank : 193)
Query Neighborhood Hits	175	Target Neighborhood Hits	674	Shared Neighborhood Hits	52
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

UHRF2_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.060170 (rank : 198)
Query Neighborhood Hits	175	Target Neighborhood Hits	269	Shared Neighborhood Hits	50
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

UHRF2_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.062557 (rank : 188)
Query Neighborhood Hits	175	Target Neighborhood Hits	275	Shared Neighborhood Hits	48
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

WDFY1_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.052744 (rank : 215)
Query Neighborhood Hits	175	Target Neighborhood Hits	305	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

WDFY2_HUMAN
θ value	θ > 10 (rank : 274)	NC score	0.051560 (rank : 219)
Query Neighborhood Hits	175	Target Neighborhood Hits	332	Shared Neighborhood Hits	30
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

WDFY2_MOUSE
θ value	θ > 10 (rank : 275)	NC score	0.051732 (rank : 218)
Query Neighborhood Hits	175	Target Neighborhood Hits	337	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

ZFY19_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.099694 (rank : 102)
Query Neighborhood Hits	175	Target Neighborhood Hits	206	Shared Neighborhood Hits	32
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

ZFY19_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.093324 (rank : 117)
Query Neighborhood Hits	175	Target Neighborhood Hits	143	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

ZN179_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.081772 (rank : 134)
Query Neighborhood Hits	175	Target Neighborhood Hits	178	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

ZN313_HUMAN
θ value	θ > 10 (rank : 279)	NC score	0.087948 (rank : 122)
Query Neighborhood Hits	175	Target Neighborhood Hits	264	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

ZN313_MOUSE
θ value	θ > 10 (rank : 280)	NC score	0.096562 (rank : 110)
Query Neighborhood Hits	175	Target Neighborhood Hits	273	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

Hits sorted by NC score

RFFL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	175	Target Neighborhood Hits	175	Shared Neighborhood Hits	175
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
NC score	0.981856 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	175	Target Neighborhood Hits	145	Shared Neighborhood Hits	123
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_HUMAN
NC score	0.926200 (rank : 3)	θ value	2.92676e-75 (rank : 3)
Query Neighborhood Hits	175	Target Neighborhood Hits	153	Shared Neighborhood Hits	105
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
NC score	0.925967 (rank : 4)	θ value	2.73936e-73 (rank : 4)
Query Neighborhood Hits	175	Target Neighborhood Hits	160	Shared Neighborhood Hits	107
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

BIRC8_HUMAN
NC score	0.511446 (rank : 5)	θ value	3.08544e-08 (rank : 11)
Query Neighborhood Hits	175	Target Neighborhood Hits	121	Shared Neighborhood Hits	69
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC7_HUMAN
NC score	0.484402 (rank : 6)	θ value	3.77169e-06 (rank : 12)
Query Neighborhood Hits	175	Target Neighborhood Hits	185	Shared Neighborhood Hits	82
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC3_MOUSE
NC score	0.468363 (rank : 7)	θ value	1.80886e-08 (rank : 8)
Query Neighborhood Hits	175	Target Neighborhood Hits	113	Shared Neighborhood Hits	76
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC3_HUMAN
NC score	0.465416 (rank : 8)	θ value	1.80886e-08 (rank : 7)
Query Neighborhood Hits	175	Target Neighborhood Hits	133	Shared Neighborhood Hits	77
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC2_HUMAN
NC score	0.462711 (rank : 9)	θ value	4.76016e-09 (rank : 5)
Query Neighborhood Hits	175	Target Neighborhood Hits	142	Shared Neighborhood Hits	74
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC2_MOUSE
NC score	0.461487 (rank : 10)	θ value	1.38499e-08 (rank : 6)
Query Neighborhood Hits	175	Target Neighborhood Hits	137	Shared Neighborhood Hits	73
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC4_HUMAN
NC score	0.452716 (rank : 11)	θ value	3.08544e-08 (rank : 9)
Query Neighborhood Hits	175	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
NC score	0.450760 (rank : 12)	θ value	3.08544e-08 (rank : 10)
Query Neighborhood Hits	175	Target Neighborhood Hits	89	Shared Neighborhood Hits	58
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

CGRF1_HUMAN
NC score	0.419365 (rank : 13)	θ value	0.000158464 (rank : 22)
Query Neighborhood Hits	175	Target Neighborhood Hits	51	Shared Neighborhood Hits	33
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

NEURL_MOUSE
NC score	0.411612 (rank : 14)	θ value	2.44474e-05 (rank : 18)
Query Neighborhood Hits	175	Target Neighborhood Hits	106	Shared Neighborhood Hits	70
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

RKHD1_HUMAN
NC score	0.411443 (rank : 15)	θ value	0.00035302 (rank : 24)
Query Neighborhood Hits	175	Target Neighborhood Hits	163	Shared Neighborhood Hits	56
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RNF26_HUMAN
NC score	0.409218 (rank : 16)	θ value	0.0148317 (rank : 35)
Query Neighborhood Hits	175	Target Neighborhood Hits	95	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

NEUL1_HUMAN
NC score	0.408715 (rank : 17)	θ value	3.19293e-05 (rank : 20)
Query Neighborhood Hits	175	Target Neighborhood Hits	114	Shared Neighborhood Hits	71
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

CGRF1_MOUSE
NC score	0.399181 (rank : 18)	θ value	0.000461057 (rank : 25)
Query Neighborhood Hits	175	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

MGRN1_MOUSE
NC score	0.337788 (rank : 19)	θ value	0.00175202 (rank : 29)
Query Neighborhood Hits	175	Target Neighborhood Hits	149	Shared Neighborhood Hits	61
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MGRN1_HUMAN
NC score	0.335368 (rank : 20)	θ value	0.00102713 (rank : 27)
Query Neighborhood Hits	175	Target Neighborhood Hits	192	Shared Neighborhood Hits	64
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MYLIP_HUMAN
NC score	0.277191 (rank : 21)	θ value	8.40245e-06 (rank : 13)
Query Neighborhood Hits	175	Target Neighborhood Hits	162	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
NC score	0.248285 (rank : 22)	θ value	2.44474e-05 (rank : 17)
Query Neighborhood Hits	175	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

LRSM1_MOUSE
NC score	0.219810 (rank : 23)	θ value	2.44474e-05 (rank : 16)
Query Neighborhood Hits	175	Target Neighborhood Hits	874	Shared Neighborhood Hits	79
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

ZFY21_MOUSE
NC score	0.217408 (rank : 24)	θ value	0.00102713 (rank : 28)
Query Neighborhood Hits	175	Target Neighborhood Hits	72	Shared Neighborhood Hits	31
SwissProt Accessions	Q8VCM3, Q9D1E2	Gene names	Zfyve21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY21_HUMAN
NC score	0.209127 (rank : 25)	θ value	0.00869519 (rank : 33)
Query Neighborhood Hits	175	Target Neighborhood Hits	72	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BQ24, Q86T05, Q96LT1	Gene names	ZFYVE21
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 21.

ZFY28_HUMAN
NC score	0.209064 (rank : 26)	θ value	0.0193708 (rank : 38)
Query Neighborhood Hits	175	Target Neighborhood Hits	152	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCC9	Gene names	ZFYVE28, KIAA1643
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 28.

RNF8_HUMAN
NC score	0.208942 (rank : 27)	θ value	0.00390308 (rank : 30)
Query Neighborhood Hits	175	Target Neighborhood Hits	622	Shared Neighborhood Hits	86
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

MDM4_HUMAN
NC score	0.207436 (rank : 28)	θ value	0.0431538 (rank : 42)
Query Neighborhood Hits	175	Target Neighborhood Hits	37	Shared Neighborhood Hits	24
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

LRSM1_HUMAN
NC score	0.201230 (rank : 29)	θ value	3.19293e-05 (rank : 19)
Query Neighborhood Hits	175	Target Neighborhood Hits	1078	Shared Neighborhood Hits	79
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

RN185_HUMAN
NC score	0.198546 (rank : 30)	θ value	0.163984 (rank : 51)
Query Neighborhood Hits	175	Target Neighborhood Hits	213	Shared Neighborhood Hits	68
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

MIB1_MOUSE
NC score	0.196824 (rank : 31)	θ value	1.43324e-05 (rank : 15)
Query Neighborhood Hits	175	Target Neighborhood Hits	471	Shared Neighborhood Hits	76
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB1_HUMAN
NC score	0.195892 (rank : 32)	θ value	1.43324e-05 (rank : 14)
Query Neighborhood Hits	175	Target Neighborhood Hits	470	Shared Neighborhood Hits	76
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MDM2_HUMAN
NC score	0.191739 (rank : 33)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	175	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

RN185_MOUSE
NC score	0.191293 (rank : 34)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	175	Target Neighborhood Hits	211	Shared Neighborhood Hits	68
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RNF8_MOUSE
NC score	0.185515 (rank : 35)	θ value	0.62314 (rank : 75)
Query Neighborhood Hits	175	Target Neighborhood Hits	618	Shared Neighborhood Hits	91
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

MDM2_MOUSE
NC score	0.180397 (rank : 36)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	175	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

MIB2_HUMAN
NC score	0.179701 (rank : 37)	θ value	0.000270298 (rank : 23)
Query Neighborhood Hits	175	Target Neighborhood Hits	438	Shared Neighborhood Hits	63
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

MIB2_MOUSE
NC score	0.178165 (rank : 38)	θ value	9.29e-05 (rank : 21)
Query Neighborhood Hits	175	Target Neighborhood Hits	409	Shared Neighborhood Hits	61
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

CBL_HUMAN
NC score	0.176087 (rank : 39)	θ value	0.21417 (rank : 54)
Query Neighborhood Hits	175	Target Neighborhood Hits	353	Shared Neighborhood Hits	80
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

ZFY16_MOUSE
NC score	0.175987 (rank : 40)	θ value	0.0431538 (rank : 44)
Query Neighborhood Hits	175	Target Neighborhood Hits	108	Shared Neighborhood Hits	32
SwissProt Accessions	Q80U44, Q8BRD2, Q8CG97	Gene names	Zfyve16, Kiaa0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosomal- associated FYVE domain protein).

CBLB_MOUSE
NC score	0.175255 (rank : 41)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	175	Target Neighborhood Hits	277	Shared Neighborhood Hits	76
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBLB_HUMAN
NC score	0.174847 (rank : 42)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	175	Target Neighborhood Hits	261	Shared Neighborhood Hits	76
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

ZFY16_HUMAN
NC score	0.174657 (rank : 43)	θ value	0.0563607 (rank : 45)
Query Neighborhood Hits	175	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	Q7Z3T8, O15023, Q7LAU7, Q86T69, Q8N5L3, Q8NEK3	Gene names	ZFYVE16, KIAA0305
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome- associated FYVE domain protein).

CBL_MOUSE
NC score	0.173605 (rank : 44)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	175	Target Neighborhood Hits	426	Shared Neighborhood Hits	83
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

ZFYV9_HUMAN
NC score	0.172148 (rank : 45)	θ value	0.0193708 (rank : 39)
Query Neighborhood Hits	175	Target Neighborhood Hits	134	Shared Neighborhood Hits	31
SwissProt Accessions	O95405, Q9UNE1, Q9Y5R7	Gene names	ZFYVE9, MADHIP, SARA, SMADIP
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Smad anchor for receptor activation) (Receptor activation anchor) (hSARA) (Novel serine protease) (NSP).

CBLC_HUMAN
NC score	0.164257 (rank : 46)	θ value	2.36792 (rank : 108)
Query Neighborhood Hits	175	Target Neighborhood Hits	173	Shared Neighborhood Hits	69
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

RN168_HUMAN
NC score	0.162927 (rank : 47)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	175	Target Neighborhood Hits	370	Shared Neighborhood Hits	75
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

PEX10_HUMAN
NC score	0.162284 (rank : 48)	θ value	2.36792 (rank : 114)
Query Neighborhood Hits	175	Target Neighborhood Hits	255	Shared Neighborhood Hits	73
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

RNF5_HUMAN
NC score	0.158561 (rank : 49)	θ value	1.06291 (rank : 91)
Query Neighborhood Hits	175	Target Neighborhood Hits	206	Shared Neighborhood Hits	68
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RNF5_MOUSE
NC score	0.154841 (rank : 50)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	175	Target Neighborhood Hits	206	Shared Neighborhood Hits	68
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

HGS_HUMAN
NC score	0.154440 (rank : 51)	θ value	0.00665767 (rank : 31)
Query Neighborhood Hits	175	Target Neighborhood Hits	517	Shared Neighborhood Hits	49
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

CBLC_MOUSE
NC score	0.153289 (rank : 52)	θ value	6.88961 (rank : 155)
Query Neighborhood Hits	175	Target Neighborhood Hits	186	Shared Neighborhood Hits	69
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

ZFY27_HUMAN
NC score	0.152663 (rank : 53)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	175	Target Neighborhood Hits	64	Shared Neighborhood Hits	32
SwissProt Accessions	Q5T4F4, Q5T4F1, Q5T4F2, Q5T4F3, Q8N1K0, Q8N6D6, Q8NCA0, Q8NDE4, Q96M08	Gene names	ZFYVE27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

HGS_MOUSE
NC score	0.152456 (rank : 54)	θ value	0.00869519 (rank : 32)
Query Neighborhood Hits	175	Target Neighborhood Hits	589	Shared Neighborhood Hits	45
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

RN123_HUMAN
NC score	0.152449 (rank : 55)	θ value	0.0193708 (rank : 37)
Query Neighborhood Hits	175	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

RN123_MOUSE
NC score	0.152365 (rank : 56)	θ value	0.0431538 (rank : 43)
Query Neighborhood Hits	175	Target Neighborhood Hits	174	Shared Neighborhood Hits	60
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

ZFY27_MOUSE
NC score	0.152097 (rank : 57)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	175	Target Neighborhood Hits	53	Shared Neighborhood Hits	32
SwissProt Accessions	Q3TXX3, Q8CFP8	Gene names	Zfyve27
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 27.

TRI26_MOUSE
NC score	0.151508 (rank : 58)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	175	Target Neighborhood Hits	339	Shared Neighborhood Hits	81
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI26_HUMAN
NC score	0.148998 (rank : 59)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	175	Target Neighborhood Hits	335	Shared Neighborhood Hits	80
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

CHFR_MOUSE
NC score	0.141392 (rank : 60)	θ value	0.47712 (rank : 68)
Query Neighborhood Hits	175	Target Neighborhood Hits	264	Shared Neighborhood Hits	63
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

TRI31_HUMAN
NC score	0.140551 (rank : 61)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	175	Target Neighborhood Hits	299	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

RN168_MOUSE
NC score	0.140551 (rank : 62)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	175	Target Neighborhood Hits	440	Shared Neighborhood Hits	78
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

CHFR_HUMAN
NC score	0.139522 (rank : 63)	θ value	0.279714 (rank : 58)
Query Neighborhood Hits	175	Target Neighborhood Hits	255	Shared Neighborhood Hits	58
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

RO52_HUMAN
NC score	0.137322 (rank : 64)	θ value	0.0148317 (rank : 36)
Query Neighborhood Hits	175	Target Neighborhood Hits	419	Shared Neighborhood Hits	82
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

SIAH2_MOUSE
NC score	0.136602 (rank : 65)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	175	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

BIRC5_MOUSE
NC score	0.136551 (rank : 66)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	175	Target Neighborhood Hits	19	Shared Neighborhood Hits	8
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

SIAH2_HUMAN
NC score	0.135994 (rank : 67)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	175	Target Neighborhood Hits	94	Shared Neighborhood Hits	39
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

TRI40_HUMAN
NC score	0.134904 (rank : 68)	θ value	2.36792 (rank : 117)
Query Neighborhood Hits	175	Target Neighborhood Hits	279	Shared Neighborhood Hits	67
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI35_MOUSE
NC score	0.133345 (rank : 69)	θ value	0.21417 (rank : 57)
Query Neighborhood Hits	175	Target Neighborhood Hits	465	Shared Neighborhood Hits	76
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRI35_HUMAN
NC score	0.132659 (rank : 70)	θ value	0.0961366 (rank : 48)
Query Neighborhood Hits	175	Target Neighborhood Hits	382	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

RN169_HUMAN
NC score	0.131179 (rank : 71)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	175	Target Neighborhood Hits	203	Shared Neighborhood Hits	47
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

ZFYV1_HUMAN
NC score	0.130165 (rank : 72)	θ value	0.813845 (rank : 86)
Query Neighborhood Hits	175	Target Neighborhood Hits	166	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HBF4, Q8WYX7, Q96K57, Q9BXP9, Q9HCI3	Gene names	ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (Tandem FYVE fingers-1) (SR3).

ZFYV1_MOUSE
NC score	0.129326 (rank : 73)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	175	Target Neighborhood Hits	153	Shared Neighborhood Hits	32
SwissProt Accessions	Q810J8	Gene names	Zfyve1
Domain Architecture
Description	Zinc finger FYVE domain-containing protein 1.

BIRC5_HUMAN
NC score	0.128608 (rank : 74)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	175	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

RO52_MOUSE
NC score	0.127976 (rank : 75)	θ value	0.0961366 (rank : 47)
Query Neighborhood Hits	175	Target Neighborhood Hits	360	Shared Neighborhood Hits	76
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

TRI50_MOUSE
NC score	0.124761 (rank : 76)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	175	Target Neighborhood Hits	326	Shared Neighborhood Hits	81
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRI12_MOUSE
NC score	0.118420 (rank : 77)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	175	Target Neighborhood Hits	387	Shared Neighborhood Hits	72
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

BIRC1_HUMAN
NC score	0.113645 (rank : 78)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	175	Target Neighborhood Hits	61	Shared Neighborhood Hits	9
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1E_MOUSE
NC score	0.113212 (rank : 79)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	175	Target Neighborhood Hits	93	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

SIA1B_MOUSE
NC score	0.113184 (rank : 80)	θ value	4.03905 (rank : 138)
Query Neighborhood Hits	175	Target Neighborhood Hits	69	Shared Neighborhood Hits	33
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

BIR1F_MOUSE
NC score	0.112659 (rank : 81)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	175	Target Neighborhood Hits	88	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
NC score	0.112601 (rank : 82)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	175	Target Neighborhood Hits	92	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

SIAH1_HUMAN
NC score	0.112448 (rank : 83)	θ value	4.03905 (rank : 139)
Query Neighborhood Hits	175	Target Neighborhood Hits	72	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

SIA1A_MOUSE
NC score	0.112354 (rank : 84)	θ value	4.03905 (rank : 137)
Query Neighborhood Hits	175	Target Neighborhood Hits	72	Shared Neighborhood Hits	33
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

BIR1B_MOUSE
NC score	0.111793 (rank : 85)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	175	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1A_MOUSE
NC score	0.110027 (rank : 86)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	175	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

RUFY1_MOUSE
NC score	0.108591 (rank : 87)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	175	Target Neighborhood Hits	765	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6	Gene names	Rufy1, Rabip4
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 1 (Rab4-interacting protein).

RUFY1_HUMAN
NC score	0.108441 (rank : 88)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	175	Target Neighborhood Hits	848	Shared Neighborhood Hits	47
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

TRI73_HUMAN
NC score	0.108436 (rank : 89)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	175	Target Neighborhood Hits	258	Shared Neighborhood Hits	71
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

TRI50_HUMAN
NC score	0.108173 (rank : 90)	θ value	6.88961 (rank : 160)
Query Neighborhood Hits	175	Target Neighborhood Hits	294	Shared Neighborhood Hits	77
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRI11_MOUSE
NC score	0.107250 (rank : 91)	θ value	0.62314 (rank : 77)
Query Neighborhood Hits	175	Target Neighborhood Hits	329	Shared Neighborhood Hits	75
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

RUFY2_MOUSE
NC score	0.107195 (rank : 92)	θ value	0.365318 (rank : 67)
Query Neighborhood Hits	175	Target Neighborhood Hits	820	Shared Neighborhood Hits	48
SwissProt Accessions	Q8R4C2, Q69ZH1	Gene names	Rufy2, Kiaa1537
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Leucine zipper FYVE-finger protein) (LZ-FYVE).

TRI11_HUMAN
NC score	0.105749 (rank : 93)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	175	Target Neighborhood Hits	316	Shared Neighborhood Hits	73
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI39_HUMAN
NC score	0.104881 (rank : 94)	θ value	0.813845 (rank : 84)
Query Neighborhood Hits	175	Target Neighborhood Hits	693	Shared Neighborhood Hits	78
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

BFAR_MOUSE
NC score	0.104131 (rank : 95)	θ value	5.27518 (rank : 144)
Query Neighborhood Hits	175	Target Neighborhood Hits	232	Shared Neighborhood Hits	60
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

TRI39_MOUSE
NC score	0.104119 (rank : 96)	θ value	0.813845 (rank : 85)
Query Neighborhood Hits	175	Target Neighborhood Hits	691	Shared Neighborhood Hits	76
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI60_HUMAN
NC score	0.104111 (rank : 97)	θ value	3.0926 (rank : 128)
Query Neighborhood Hits	175	Target Neighborhood Hits	357	Shared Neighborhood Hits	76
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

TRI27_MOUSE
NC score	0.103583 (rank : 98)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	175	Target Neighborhood Hits	261	Shared Neighborhood Hits	76
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRIM4_HUMAN
NC score	0.102498 (rank : 99)	θ value	6.88961 (rank : 161)
Query Neighborhood Hits	175	Target Neighborhood Hits	321	Shared Neighborhood Hits	72
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

TRI74_HUMAN
NC score	0.100930 (rank : 100)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	175	Target Neighborhood Hits	249	Shared Neighborhood Hits	68
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

BFAR_HUMAN
NC score	0.100069 (rank : 101)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	175	Target Neighborhood Hits	222	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

ZFY19_HUMAN
NC score	0.099694 (rank : 102)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	175	Target Neighborhood Hits	206	Shared Neighborhood Hits	32
SwissProt Accessions	Q96K21, Q86WC2, Q8WU96	Gene names	ZFYVE19, MPFYVE
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19 (MLL partner containing FYVE domain).

RN141_HUMAN
NC score	0.098318 (rank : 103)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	175	Target Neighborhood Hits	199	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

TRI17_MOUSE
NC score	0.098123 (rank : 104)	θ value	5.27518 (rank : 151)
Query Neighborhood Hits	175	Target Neighborhood Hits	620	Shared Neighborhood Hits	71
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

TRI65_MOUSE
NC score	0.098075 (rank : 105)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	175	Target Neighborhood Hits	340	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

WDFY3_HUMAN
NC score	0.098041 (rank : 106)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	175	Target Neighborhood Hits	348	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IZQ1, Q4W5K5, Q6P0Q5, Q8N1T2, Q96BS7, Q96N85, Q9Y2J7	Gene names	WDFY3, KIAA0993
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy).

WDFY3_MOUSE
NC score	0.097991 (rank : 107)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	175	Target Neighborhood Hits	332	Shared Neighborhood Hits	34
SwissProt Accessions	Q6VNB8, Q8C8H7	Gene names	Wdfy3
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 3 (Beach domain, WD repeat and FYVE domain-containing protein 1) (BWF1).

RN141_MOUSE
NC score	0.097411 (rank : 108)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	175	Target Neighborhood Hits	200	Shared Neighborhood Hits	54
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

MDM4_MOUSE
NC score	0.096815 (rank : 109)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	175	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

ZN313_MOUSE
NC score	0.096562 (rank : 110)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	175	Target Neighborhood Hits	273	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

TRI17_HUMAN
NC score	0.096159 (rank : 111)	θ value	8.99809 (rank : 173)
Query Neighborhood Hits	175	Target Neighborhood Hits	318	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

PCQAP_HUMAN
NC score	0.096139 (rank : 112)	θ value	0.000786445 (rank : 26)
Query Neighborhood Hits	175	Target Neighborhood Hits	549	Shared Neighborhood Hits	17
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

TRIM5_HUMAN
NC score	0.096105 (rank : 113)	θ value	8.99809 (rank : 174)
Query Neighborhood Hits	175	Target Neighborhood Hits	424	Shared Neighborhood Hits	76
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

TRI52_HUMAN
NC score	0.095930 (rank : 114)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	175	Target Neighborhood Hits	213	Shared Neighborhood Hits	54
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TRI43_HUMAN
NC score	0.095038 (rank : 115)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	175	Target Neighborhood Hits	341	Shared Neighborhood Hits	70
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI27_HUMAN
NC score	0.095005 (rank : 116)	θ value	4.03905 (rank : 142)
Query Neighborhood Hits	175	Target Neighborhood Hits	273	Shared Neighborhood Hits	72
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

ZFY19_MOUSE
NC score	0.093324 (rank : 117)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	175	Target Neighborhood Hits	143	Shared Neighborhood Hits	30
SwissProt Accessions	Q9DAZ9, Q8VCV7	Gene names	Zfyve19
Domain Architecture	No domain graphic available
Description	Zinc finger FYVE domain-containing protein 19.

PKHF1_HUMAN
NC score	0.090102 (rank : 118)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	175	Target Neighborhood Hits	76	Shared Neighborhood Hits	27
SwissProt Accessions	Q96S99, Q96K11, Q9BUB9	Gene names	PLEKHF1, APPD, LAPF, ZFYVE15
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (PH and FYVE domain-containing protein 1) (Phafin-1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains) (Apoptosis-inducing protein) (Zinc finger FYVE domain-containing protein 15).

PCQAP_MOUSE
NC score	0.089901 (rank : 119)	θ value	0.279714 (rank : 62)
Query Neighborhood Hits	175	Target Neighborhood Hits	506	Shared Neighborhood Hits	21
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

RUFY2_HUMAN
NC score	0.089498 (rank : 120)	θ value	0.365318 (rank : 66)
Query Neighborhood Hits	175	Target Neighborhood Hits	1208	Shared Neighborhood Hits	54
SwissProt Accessions	Q8WXA3, Q96P51, Q9P1Z1	Gene names	RUFY2, KIAA1537, RABIP4R
Domain Architecture	No domain graphic available
Description	RUN and FYVE domain-containing protein 2 (Rab4-interacting protein related).

TRI65_HUMAN
NC score	0.088465 (rank : 121)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	175	Target Neighborhood Hits	330	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

ZN313_HUMAN
NC score	0.087948 (rank : 122)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	175	Target Neighborhood Hits	264	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

AMFR2_HUMAN
NC score	0.087210 (rank : 123)	θ value	3.0926 (rank : 118)
Query Neighborhood Hits	175	Target Neighborhood Hits	219	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UKV5, Q8IZ70	Gene names	AMFR
Domain Architecture
Description	Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78).

BRCA1_MOUSE
NC score	0.086838 (rank : 124)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	175	Target Neighborhood Hits	436	Shared Neighborhood Hits	72
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

PKHF1_MOUSE
NC score	0.086622 (rank : 125)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	175	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q3TB82, Q99M16	Gene names	Plekhf1, Lapf
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 1 (PH domain- containing family F member 1) (Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains).

TRI68_MOUSE
NC score	0.086168 (rank : 126)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	175	Target Neighborhood Hits	356	Shared Neighborhood Hits	68
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

AMFR_MOUSE
NC score	0.086085 (rank : 127)	θ value	3.0926 (rank : 119)
Query Neighborhood Hits	175	Target Neighborhood Hits	208	Shared Neighborhood Hits	56
SwissProt Accessions	Q9R049, Q8K008, Q99LH5	Gene names	Amfr
Domain Architecture
Description	Autocrine motility factor receptor (EC 6.3.2.19) (AMF receptor).

TRI15_HUMAN
NC score	0.084647 (rank : 128)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	175	Target Neighborhood Hits	395	Shared Neighborhood Hits	62
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

BIRC6_HUMAN
NC score	0.084372 (rank : 129)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	175	Target Neighborhood Hits	161	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

TRI30_MOUSE
NC score	0.084092 (rank : 130)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	175	Target Neighborhood Hits	434	Shared Neighborhood Hits	62
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TOPRS_MOUSE
NC score	0.084040 (rank : 131)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	175	Target Neighborhood Hits	263	Shared Neighborhood Hits	54
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

FYV1_MOUSE
NC score	0.082369 (rank : 132)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	175	Target Neighborhood Hits	191	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z1T6	Gene names	Pip5k3, Pikfyve
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (PIP5K) (PtdIns(4)P-5- kinase) (PIKfyve) (p235).

FYV1_HUMAN
NC score	0.081980 (rank : 133)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	175	Target Neighborhood Hits	217	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y2I7, Q8NB67	Gene names	PIP5K3, KIAA0981, PIKFYVE
Domain Architecture
Description	FYVE finger-containing phosphoinositide kinase (EC 2.7.1.68) (1- phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3- phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve) (p235).

ZN179_HUMAN
NC score	0.081772 (rank : 134)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	175	Target Neighborhood Hits	178	Shared Neighborhood Hits	51
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

RN125_HUMAN
NC score	0.081564 (rank : 135)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	175	Target Neighborhood Hits	230	Shared Neighborhood Hits	62
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

TRI22_HUMAN
NC score	0.081490 (rank : 136)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	175	Target Neighborhood Hits	396	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRIM6_MOUSE
NC score	0.081335 (rank : 137)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	175	Target Neighborhood Hits	451	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

MTMR3_HUMAN
NC score	0.081132 (rank : 138)	θ value	2.36792 (rank : 111)
Query Neighborhood Hits	175	Target Neighborhood Hits	163	Shared Neighborhood Hits	33
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

TOPRS_HUMAN
NC score	0.080745 (rank : 139)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	175	Target Neighborhood Hits	286	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

RFWD2_MOUSE
NC score	0.080563 (rank : 140)	θ value	3.0926 (rank : 126)
Query Neighborhood Hits	175	Target Neighborhood Hits	535	Shared Neighborhood Hits	64
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

TRI25_MOUSE
NC score	0.080234 (rank : 141)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	175	Target Neighborhood Hits	446	Shared Neighborhood Hits	72
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

TRI34_HUMAN
NC score	0.080082 (rank : 142)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	175	Target Neighborhood Hits	416	Shared Neighborhood Hits	65
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

PKHF2_HUMAN
NC score	0.079235 (rank : 143)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	175	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H8W4	Gene names	PLEKHF2, ZFYVE18
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2) (PH and FYVE domain-containing protein 2) (Phafin-2) (Zinc finger FYVE domain-containing protein 18).

PKHF2_MOUSE
NC score	0.079215 (rank : 144)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	175	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q91WB4	Gene names	Plekhf2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family F member 2 (PH domain- containing family F member 2).

TRI10_HUMAN
NC score	0.079183 (rank : 145)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	175	Target Neighborhood Hits	315	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRI48_HUMAN
NC score	0.078964 (rank : 146)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	175	Target Neighborhood Hits	192	Shared Neighborhood Hits	51
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRI68_HUMAN
NC score	0.078873 (rank : 147)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	175	Target Neighborhood Hits	267	Shared Neighborhood Hits	59
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

TRI34_MOUSE
NC score	0.078676 (rank : 148)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	175	Target Neighborhood Hits	332	Shared Neighborhood Hits	55
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRI25_HUMAN
NC score	0.077952 (rank : 149)	θ value	5.27518 (rank : 152)
Query Neighborhood Hits	175	Target Neighborhood Hits	472	Shared Neighborhood Hits	70
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

FGD5_MOUSE
NC score	0.077786 (rank : 150)	θ value	2.36792 (rank : 110)
Query Neighborhood Hits	175	Target Neighborhood Hits	170	Shared Neighborhood Hits	33
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

BRCA1_HUMAN
NC score	0.077676 (rank : 151)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	175	Target Neighborhood Hits	381	Shared Neighborhood Hits	66
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

TRI41_HUMAN
NC score	0.077592 (rank : 152)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	175	Target Neighborhood Hits	349	Shared Neighborhood Hits	56
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

RFWD2_HUMAN
NC score	0.077563 (rank : 153)	θ value	3.0926 (rank : 125)
Query Neighborhood Hits	175	Target Neighborhood Hits	518	Shared Neighborhood Hits	61
SwissProt Accessions	Q8NHY2, Q6H103, Q9H6L7	Gene names	RFWD2, COP1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1).

TRIM6_HUMAN
NC score	0.077291 (rank : 154)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	175	Target Neighborhood Hits	412	Shared Neighborhood Hits	58
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

RNF4_HUMAN
NC score	0.076435 (rank : 155)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	175	Target Neighborhood Hits	212	Shared Neighborhood Hits	61
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

TRI10_MOUSE
NC score	0.075951 (rank : 156)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	175	Target Neighborhood Hits	285	Shared Neighborhood Hits	59
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRI38_HUMAN
NC score	0.075576 (rank : 157)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	175	Target Neighborhood Hits	373	Shared Neighborhood Hits	57
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

FGD5_HUMAN
NC score	0.075547 (rank : 158)	θ value	3.0926 (rank : 121)
Query Neighborhood Hits	175	Target Neighborhood Hits	235	Shared Neighborhood Hits	32
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

TRI49_HUMAN
NC score	0.074813 (rank : 159)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	175	Target Neighborhood Hits	199	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

TRI60_MOUSE
NC score	0.074731 (rank : 160)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	175	Target Neighborhood Hits	240	Shared Neighborhood Hits	51
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

RN125_MOUSE
NC score	0.074698 (rank : 161)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	175	Target Neighborhood Hits	220	Shared Neighborhood Hits	62
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

RNF4_MOUSE
NC score	0.073562 (rank : 162)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	175	Target Neighborhood Hits	212	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

ANFY1_MOUSE
NC score	0.072833 (rank : 163)	θ value	4.03905 (rank : 130)
Query Neighborhood Hits	175	Target Neighborhood Hits	480	Shared Neighborhood Hits	39
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

TRIM7_HUMAN
NC score	0.071997 (rank : 164)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	175	Target Neighborhood Hits	336	Shared Neighborhood Hits	52
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

RN166_HUMAN
NC score	0.071955 (rank : 165)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	175	Target Neighborhood Hits	240	Shared Neighborhood Hits	61
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

TRI62_HUMAN
NC score	0.071679 (rank : 166)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	175	Target Neighborhood Hits	584	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRIM7_MOUSE
NC score	0.071655 (rank : 167)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	175	Target Neighborhood Hits	358	Shared Neighborhood Hits	52
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

RN166_MOUSE
NC score	0.071387 (rank : 168)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	175	Target Neighborhood Hits	248	Shared Neighborhood Hits	61
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

TRI62_MOUSE
NC score	0.071106 (rank : 169)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	175	Target Neighborhood Hits	478	Shared Neighborhood Hits	60
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

ANFY1_HUMAN
NC score	0.070382 (rank : 170)	θ value	4.03905 (rank : 129)
Query Neighborhood Hits	175	Target Neighborhood Hits	480	Shared Neighborhood Hits	39
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

RNF13_HUMAN
NC score	0.068717 (rank : 171)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	175	Target Neighborhood Hits	147	Shared Neighborhood Hits	28
SwissProt Accessions	O43567	Gene names	RNF13, RZF
Domain Architecture
Description	RING finger protein 13.

SMRA3_MOUSE
NC score	0.067509 (rank : 172)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	175	Target Neighborhood Hits	267	Shared Neighborhood Hits	64
SwissProt Accessions	Q6PCN7, O35596, O35597, Q80VT6	Gene names	Smarca3, Snf2l3, Zbu1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein) (P113).

RN146_HUMAN
NC score	0.067350 (rank : 173)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	175	Target Neighborhood Hits	162	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

TRI13_MOUSE
NC score	0.067015 (rank : 174)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	175	Target Neighborhood Hits	282	Shared Neighborhood Hits	56
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

RN146_MOUSE
NC score	0.066393 (rank : 175)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	175	Target Neighborhood Hits	161	Shared Neighborhood Hits	52
SwissProt Accessions	Q9CZW6, Q3TF93	Gene names	Rnf146
Domain Architecture	No domain graphic available
Description	RING finger protein 146.

TRI47_MOUSE
NC score	0.065700 (rank : 176)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	175	Target Neighborhood Hits	295	Shared Neighborhood Hits	63
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRI47_HUMAN
NC score	0.064763 (rank : 177)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	175	Target Neighborhood Hits	286	Shared Neighborhood Hits	62
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRI37_MOUSE
NC score	0.064760 (rank : 178)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	175	Target Neighborhood Hits	316	Shared Neighborhood Hits	52
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRI13_HUMAN
NC score	0.064621 (rank : 179)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	175	Target Neighborhood Hits	274	Shared Neighborhood Hits	54
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

TRI37_HUMAN
NC score	0.064490 (rank : 180)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	175	Target Neighborhood Hits	307	Shared Neighborhood Hits	51
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

RING1_HUMAN
NC score	0.064474 (rank : 181)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	175	Target Neighborhood Hits	219	Shared Neighborhood Hits	53
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

RBNS5_HUMAN
NC score	0.064140 (rank : 182)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	175	Target Neighborhood Hits	242	Shared Neighborhood Hits	35
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

TRI59_MOUSE
NC score	0.064090 (rank : 183)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	175	Target Neighborhood Hits	292	Shared Neighborhood Hits	56
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

SMRA3_HUMAN
NC score	0.063771 (rank : 184)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	175	Target Neighborhood Hits	265	Shared Neighborhood Hits	62
SwissProt Accessions	Q14527, Q14536, Q16051, Q7KYJ6, Q86YA5, Q92652, Q96KM9	Gene names	SMARCA3, HIP116A, HLTF, SNF2L3, ZBU1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (Helicase-like transcription factor) (HIP116).

RN183_HUMAN
NC score	0.063434 (rank : 185)	θ value	3.0926 (rank : 127)
Query Neighborhood Hits	175	Target Neighborhood Hits	126	Shared Neighborhood Hits	31
SwissProt Accessions	Q96D59	Gene names	RNF183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

RBNS5_MOUSE
NC score	0.063360 (rank : 186)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	175	Target Neighborhood Hits	266	Shared Neighborhood Hits	33
SwissProt Accessions	Q80Y56, Q8K0L6, Q9CTW0	Gene names	Zfyve20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20).

RING1_MOUSE
NC score	0.063203 (rank : 187)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	175	Target Neighborhood Hits	220	Shared Neighborhood Hits	53
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

UHRF2_MOUSE
NC score	0.062557 (rank : 188)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	175	Target Neighborhood Hits	275	Shared Neighborhood Hits	48
SwissProt Accessions	Q7TMI3, Q8BG56, Q8BJP6, Q8BY30, Q8K1I5	Gene names	Uhrf2, Nirf
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95-like ring finger protein) (Nuclear zinc finger protein Np97) (NIRF).

TRI32_HUMAN
NC score	0.062141 (rank : 189)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	175	Target Neighborhood Hits	264	Shared Neighborhood Hits	54
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI59_HUMAN
NC score	0.061894 (rank : 190)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	175	Target Neighborhood Hits	307	Shared Neighborhood Hits	53
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI32_MOUSE
NC score	0.061486 (rank : 191)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	175	Target Neighborhood Hits	271	Shared Neighborhood Hits	53
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

EEA1_MOUSE
NC score	0.061008 (rank : 192)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	175	Target Neighborhood Hits	1637	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BL66, Q6DIC2	Gene names	Eea1
Domain Architecture	No domain graphic available
Description	Early endosome antigen 1.

TRIM8_MOUSE
NC score	0.061000 (rank : 193)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	175	Target Neighborhood Hits	674	Shared Neighborhood Hits	52
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

EEA1_HUMAN
NC score	0.060950 (rank : 194)	θ value	0.47712 (rank : 69)
Query Neighborhood Hits	175	Target Neighborhood Hits	1796	Shared Neighborhood Hits	63
SwissProt Accessions	Q15075, Q14221	Gene names	EEA1, ZFYVE2
Domain Architecture
Description	Early endosome antigen 1 (Endosome-associated protein p162) (Zinc finger FYVE domain-containing protein 2).

TRIM8_HUMAN
NC score	0.060829 (rank : 195)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	175	Target Neighborhood Hits	650	Shared Neighborhood Hits	51
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

FGD6_MOUSE
NC score	0.060556 (rank : 196)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	175	Target Neighborhood Hits	282	Shared Neighborhood Hits	31
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

RFPL2_HUMAN
NC score	0.060425 (rank : 197)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	175	Target Neighborhood Hits	126	Shared Neighborhood Hits	38
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

UHRF2_HUMAN
NC score	0.060170 (rank : 198)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	175	Target Neighborhood Hits	269	Shared Neighborhood Hits	50
SwissProt Accessions	Q96PU4, Q5VYR1, Q5VYR3, Q659C8, Q8TAG7	Gene names	UHRF2, NIRF, RNF107
Domain Architecture	No domain graphic available
Description	Ubiquitin-like PHD and RING finger domain-containing protein 2 (EC 6.3.2.-) (Ubiquitin-like-containing PHD and RING finger domains protein 2) (Np95/ICBP90-like RING finger protein) (Np95-like RING finger protein) (Nuclear zinc finger protein Np97) (RING finger protein 107).

TRIM3_HUMAN
NC score	0.059692 (rank : 199)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	175	Target Neighborhood Hits	357	Shared Neighborhood Hits	68
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRIM2_HUMAN
NC score	0.058847 (rank : 200)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	175	Target Neighborhood Hits	330	Shared Neighborhood Hits	65
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

FGD6_HUMAN
NC score	0.058780 (rank : 201)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	175	Target Neighborhood Hits	237	Shared Neighborhood Hits	28
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

TRIM2_MOUSE
NC score	0.058122 (rank : 202)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	175	Target Neighborhood Hits	331	Shared Neighborhood Hits	65
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

RING2_HUMAN
NC score	0.057862 (rank : 203)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	175	Target Neighborhood Hits	201	Shared Neighborhood Hits	50
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
NC score	0.057858 (rank : 204)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	175	Target Neighborhood Hits	199	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

FGD3_HUMAN
NC score	0.057568 (rank : 205)	θ value	8.99809 (rank : 166)
Query Neighborhood Hits	175	Target Neighborhood Hits	249	Shared Neighborhood Hits	31
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

MEFV_MOUSE
NC score	0.057410 (rank : 206)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	175	Target Neighborhood Hits	236	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

MEFV_HUMAN
NC score	0.057260 (rank : 207)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	175	Target Neighborhood Hits	431	Shared Neighborhood Hits	27
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

RFPL3_HUMAN
NC score	0.057248 (rank : 208)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	175	Target Neighborhood Hits	134	Shared Neighborhood Hits	34
SwissProt Accessions	O75679, Q6IC04	Gene names	RFPL3
Domain Architecture
Description	Ret finger protein-like 3.

RNF39_HUMAN
NC score	0.056921 (rank : 209)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	175	Target Neighborhood Hits	200	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

TRIM3_MOUSE
NC score	0.056901 (rank : 210)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	175	Target Neighborhood Hits	351	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRI56_HUMAN
NC score	0.056683 (rank : 211)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	175	Target Neighborhood Hits	339	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

RFPL1_HUMAN
NC score	0.055626 (rank : 212)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	175	Target Neighborhood Hits	119	Shared Neighborhood Hits	31
SwissProt Accessions	O75677, Q6IC06	Gene names	RFPL1, RFPL1L, RNF78
Domain Architecture
Description	Ret finger protein-like 1 (RING finger protein 78).

RN183_MOUSE
NC score	0.055273 (rank : 213)	θ value	5.27518 (rank : 147)
Query Neighborhood Hits	175	Target Neighborhood Hits	119	Shared Neighborhood Hits	28
SwissProt Accessions	Q8QZS5, Q5NBV8	Gene names	Rnf183
Domain Architecture	No domain graphic available
Description	RING finger protein 183.

RNF13_MOUSE
NC score	0.054598 (rank : 214)	θ value	5.27518 (rank : 148)
Query Neighborhood Hits	175	Target Neighborhood Hits	164	Shared Neighborhood Hits	29
SwissProt Accessions	O54965, O54966	Gene names	Rnf13, Rzf
Domain Architecture
Description	RING finger protein 13.

WDFY1_HUMAN
NC score	0.052744 (rank : 215)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	175	Target Neighborhood Hits	305	Shared Neighborhood Hits	30
SwissProt Accessions	Q8IWB7, Q9H9D5, Q9P2B3	Gene names	WDFY1, KIAA1435, WDF1, ZFYVE17
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 1 (WD40- and FYVE domain- containing protein 1) (Phosphoinositide-binding protein 1) (FENS-1) (Zinc finger FYVE domain-containing protein 17).

FGD2_HUMAN
NC score	0.052085 (rank : 216)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	175	Target Neighborhood Hits	151	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
NC score	0.051823 (rank : 217)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	175	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

WDFY2_MOUSE
NC score	0.051732 (rank : 218)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	175	Target Neighborhood Hits	337	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BUB4	Gene names	Wdfy2
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2).

WDFY2_HUMAN
NC score	0.051560 (rank : 219)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	175	Target Neighborhood Hits	332	Shared Neighborhood Hits	30
SwissProt Accessions	Q96P53, Q96CS1	Gene names	WDFY2, WDF2, ZFYVE22
Domain Architecture	No domain graphic available
Description	WD repeat and FYVE domain-containing protein 2 (WD40- and FYVE domain- containing protein 2) (Zinc finger FYVE domain-containing protein 22).

TRI63_HUMAN
NC score	0.051377 (rank : 220)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	175	Target Neighborhood Hits	298	Shared Neighborhood Hits	46
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TRI56_MOUSE
NC score	0.051009 (rank : 221)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	175	Target Neighborhood Hits	255	Shared Neighborhood Hits	59
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

ERMAP_HUMAN
NC score	0.050515 (rank : 222)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	175	Target Neighborhood Hits	155	Shared Neighborhood Hits	20
SwissProt Accessions	Q96PL5, Q5VV53, Q6DUE0, Q7Z3X0, Q8NCV8, Q8NCW2, Q8NCW3, Q96PL6	Gene names	ERMAP, RD, SC
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor (hERMAP) (Scianna blood group antigen) (Radin blood group antigen).

PRR11_MOUSE
NC score	0.049393 (rank : 223)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	175	Target Neighborhood Hits	36	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BHE0, Q3V3H1	Gene names	Prr11
Domain Architecture	No domain graphic available
Description	Proline-rich protein 11.

MORC4_MOUSE
NC score	0.048779 (rank : 224)	θ value	0.0113563 (rank : 34)
Query Neighborhood Hits	175	Target Neighborhood Hits	235	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BMD7, Q4KMM6, Q8BX95, Q9CS96	Gene names	Morc4, Zcwcc2
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled- coil domain protein 2).

FGD3_MOUSE
NC score	0.048043 (rank : 225)	θ value	2.36792 (rank : 109)
Query Neighborhood Hits	175	Target Neighborhood Hits	257	Shared Neighborhood Hits	30
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

CUTL2_HUMAN
NC score	0.047319 (rank : 226)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	175	Target Neighborhood Hits	906	Shared Neighborhood Hits	23
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

CUTL2_MOUSE
NC score	0.043548 (rank : 227)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	175	Target Neighborhood Hits	771	Shared Neighborhood Hits	15
SwissProt Accessions	P70298	Gene names	Cutl2
Domain Architecture
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

PCLO_MOUSE
NC score	0.043497 (rank : 228)	θ value	0.0252991 (rank : 40)
Query Neighborhood Hits	175	Target Neighborhood Hits	2275	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TRAF7_MOUSE
NC score	0.042782 (rank : 229)	θ value	8.99809 (rank : 172)
Query Neighborhood Hits	175	Target Neighborhood Hits	470	Shared Neighborhood Hits	63
SwissProt Accessions	Q922B6, Q99JV3	Gene names	Traf7
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7).

TRAF7_HUMAN
NC score	0.041669 (rank : 230)	θ value	8.99809 (rank : 171)
Query Neighborhood Hits	175	Target Neighborhood Hits	482	Shared Neighborhood Hits	64
SwissProt Accessions	Q6Q0C0, Q9H073	Gene names	TRAF7, RFWD1, RNF119
Domain Architecture	No domain graphic available
Description	E3 ubiquitin protein ligase TRAF7 (EC 6.3.2.-) (TNF receptor- associated factor 7) (RING finger and WD repeat domain protein 1) (RING finger protein 119).

UBP34_HUMAN
NC score	0.037353 (rank : 231)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	175	Target Neighborhood Hits	210	Shared Neighborhood Hits	5
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

BTBD7_HUMAN
NC score	0.034850 (rank : 232)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	175	Target Neighborhood Hits	176	Shared Neighborhood Hits	7
SwissProt Accessions	Q9P203, Q69Z05, Q7Z308, Q86TS0, Q9HAA4, Q9NVM0	Gene names	BTBD7, KIAA1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

BTBD7_MOUSE
NC score	0.034530 (rank : 233)	θ value	3.0926 (rank : 120)
Query Neighborhood Hits	175	Target Neighborhood Hits	228	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CFE5, Q80TC3, Q8BZY9	Gene names	Btbd7, Kiaa1525
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 7.

TIRAP_MOUSE
NC score	0.034486 (rank : 234)	θ value	1.06291 (rank : 92)
Query Neighborhood Hits	175	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	Q99JY1, Q91ZW0	Gene names	Tirap, Mal
Domain Architecture
Description	Toll-interleukin 1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (MyD88 adapter-like protein) (Adaptor protein Wyatt).

DEN1A_HUMAN
NC score	0.033869 (rank : 235)	θ value	0.125558 (rank : 49)
Query Neighborhood Hits	175	Target Neighborhood Hits	176	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TEH3, Q5VWF0, Q8IVD6, Q9H796	Gene names	DENND1A
Domain Architecture	No domain graphic available
Description	DENN domain-containing protein 1A.

PCLO_HUMAN
NC score	0.033557 (rank : 236)	θ value	2.36792 (rank : 113)
Query Neighborhood Hits	175	Target Neighborhood Hits	2046	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

MYRIP_HUMAN
NC score	0.033053 (rank : 237)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	175	Target Neighborhood Hits	269	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NFW9, Q8IUF5, Q9Y3V4	Gene names	MYRIP, SLAC2C
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

UBP34_MOUSE
NC score	0.031885 (rank : 238)	θ value	1.81305 (rank : 106)
Query Neighborhood Hits	175	Target Neighborhood Hits	189	Shared Neighborhood Hits	5
SwissProt Accessions	Q6ZQ93, Q3UPN0, Q6P563, Q7TMJ6, Q8CCH0	Gene names	Usp34, Kiaa0570
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

ANK3_HUMAN
NC score	0.028789 (rank : 239)	θ value	4.03905 (rank : 131)
Query Neighborhood Hits	175	Target Neighborhood Hits	853	Shared Neighborhood Hits	20
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

GOGB1_HUMAN
NC score	0.028684 (rank : 240)	θ value	0.163984 (rank : 50)
Query Neighborhood Hits	175	Target Neighborhood Hits	2297	Shared Neighborhood Hits	53
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ANR15_HUMAN
NC score	0.028649 (rank : 241)	θ value	6.88961 (rank : 153)
Query Neighborhood Hits	175	Target Neighborhood Hits	478	Shared Neighborhood Hits	17
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

NCOA6_MOUSE
NC score	0.027641 (rank : 242)	θ value	4.03905 (rank : 135)
Query Neighborhood Hits	175	Target Neighborhood Hits	1076	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PI51C_HUMAN
NC score	0.027346 (rank : 243)	θ value	0.47712 (rank : 70)
Query Neighborhood Hits	175	Target Neighborhood Hits	109	Shared Neighborhood Hits	5
SwissProt Accessions	O60331, Q7LE07	Gene names	PIP5K1C, KIAA0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

ANR41_HUMAN
NC score	0.025625 (rank : 244)	θ value	8.99809 (rank : 163)
Query Neighborhood Hits	175	Target Neighborhood Hits	332	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

SYN3_HUMAN
NC score	0.023506 (rank : 245)	θ value	4.03905 (rank : 140)
Query Neighborhood Hits	175	Target Neighborhood Hits	203	Shared Neighborhood Hits	8
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

IQEC3_HUMAN
NC score	0.023313 (rank : 246)	θ value	0.21417 (rank : 56)
Query Neighborhood Hits	175	Target Neighborhood Hits	125	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPP2, Q8TB43	Gene names	IQSEC3, KIAA1110
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 3.

T22D2_HUMAN
NC score	0.023109 (rank : 247)	θ value	2.36792 (rank : 116)
Query Neighborhood Hits	175	Target Neighborhood Hits	250	Shared Neighborhood Hits	8
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

SYN3_MOUSE
NC score	0.022998 (rank : 248)	θ value	5.27518 (rank : 150)
Query Neighborhood Hits	175	Target Neighborhood Hits	200	Shared Neighborhood Hits	10
SwissProt Accessions	Q8JZP2	Gene names	Syn3
Domain Architecture	No domain graphic available
Description	Synapsin-3 (Synapsin III).

LPIN2_MOUSE
NC score	0.022867 (rank : 249)	θ value	3.0926 (rank : 122)
Query Neighborhood Hits	175	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	Q99PI5, Q8C357, Q8C7I8, Q8CC85, Q8CHR7	Gene names	Lpin2
Domain Architecture
Description	Lipin-2.

LPIN3_HUMAN
NC score	0.022366 (rank : 250)	θ value	4.03905 (rank : 133)
Query Neighborhood Hits	175	Target Neighborhood Hits	92	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BQK8, Q5TDB9, Q9NPY8, Q9UJE5	Gene names	LPIN3, LIPN3L
Domain Architecture	No domain graphic available
Description	Lipin-3 (Lipin 3-like).

PI51C_MOUSE
NC score	0.022023 (rank : 251)	θ value	4.03905 (rank : 136)
Query Neighborhood Hits	175	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O70161, Q505A1, Q80TW9, Q8VCU5	Gene names	Pip5k1c, Kiaa0589
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I gamma) (PtdIns(4)P- 5-kinase gamma) (PtdInsPKIgamma) (PIP5KIgamma).

ARI1A_HUMAN
NC score	0.021966 (rank : 252)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	175	Target Neighborhood Hits	787	Shared Neighborhood Hits	16
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

CP250_MOUSE
NC score	0.020797 (rank : 253)	θ value	5.27518 (rank : 145)
Query Neighborhood Hits	175	Target Neighborhood Hits	1583	Shared Neighborhood Hits	39
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

SETD8_HUMAN
NC score	0.020346 (rank : 254)	θ value	1.81305 (rank : 105)
Query Neighborhood Hits	175	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NQR1, Q86W83, Q8TD09	Gene names	SETD8, PRSET7, SET07, SET8
Domain Architecture
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8) (PR/SET domain-containing protein 07) (PR/SET07) (PR-Set7).

LPIN2_HUMAN
NC score	0.020290 (rank : 255)	θ value	6.88961 (rank : 157)
Query Neighborhood Hits	175	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	Q92539	Gene names	LPIN2, KIAA0249
Domain Architecture	No domain graphic available
Description	Lipin-2.

PO6F2_MOUSE
NC score	0.019741 (rank : 256)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	175	Target Neighborhood Hits	639	Shared Neighborhood Hits	15
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PO6F2_HUMAN
NC score	0.017910 (rank : 257)	θ value	3.0926 (rank : 124)
Query Neighborhood Hits	175	Target Neighborhood Hits	618	Shared Neighborhood Hits	14
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

MINT_HUMAN
NC score	0.017639 (rank : 258)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	175	Target Neighborhood Hits	1291	Shared Neighborhood Hits	23
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NCOR1_HUMAN
NC score	0.017588 (rank : 259)	θ value	2.36792 (rank : 112)
Query Neighborhood Hits	175	Target Neighborhood Hits	577	Shared Neighborhood Hits	16
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

BRMS1_HUMAN
NC score	0.016495 (rank : 260)	θ value	8.99809 (rank : 164)
Query Neighborhood Hits	175	Target Neighborhood Hits	60	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HCU9	Gene names	BRMS1
Domain Architecture	No domain graphic available
Description	Breast cancer metastasis-suppressor 1.

NEUM_HUMAN
NC score	0.015708 (rank : 261)	θ value	6.88961 (rank : 159)
Query Neighborhood Hits	175	Target Neighborhood Hits	132	Shared Neighborhood Hits	5
SwissProt Accessions	P17677	Gene names	GAP43
Domain Architecture
Description	Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (PP46) (Neural phosphoprotein B-50).

CABYR_MOUSE
NC score	0.013115 (rank : 262)	θ value	8.99809 (rank : 165)
Query Neighborhood Hits	175	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q9D424, Q91Y41, Q91Y42	Gene names	Cabyr, Cbp86
Domain Architecture	No domain graphic available
Description	Calcium-binding tyrosine phosphorylation-regulated protein (Calcium- binding protein 86) (Testis-specific calcium-binding protein CBP86).

NPAS2_HUMAN
NC score	0.011680 (rank : 263)	θ value	3.0926 (rank : 123)
Query Neighborhood Hits	175	Target Neighborhood Hits	150	Shared Neighborhood Hits	8
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

SIN3B_MOUSE
NC score	0.011464 (rank : 264)	θ value	5.27518 (rank : 149)
Query Neighborhood Hits	175	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q62141, O54976, Q6A013, Q8VCB8, Q8VDZ5	Gene names	Sin3b, Kiaa0700
Domain Architecture
Description	Paired amphipathic helix protein Sin3b (Transcriptional corepressor Sin3b) (Histone deacetylase complex subunit Sin3b).

WASIP_HUMAN
NC score	0.011328 (rank : 265)	θ value	8.99809 (rank : 175)
Query Neighborhood Hits	175	Target Neighborhood Hits	458	Shared Neighborhood Hits	9
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

KI21A_MOUSE
NC score	0.010854 (rank : 266)	θ value	5.27518 (rank : 146)
Query Neighborhood Hits	175	Target Neighborhood Hits	1317	Shared Neighborhood Hits	34
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

KCNN3_MOUSE
NC score	0.010471 (rank : 267)	θ value	8.99809 (rank : 168)
Query Neighborhood Hits	175	Target Neighborhood Hits	171	Shared Neighborhood Hits	10
SwissProt Accessions	P58391	Gene names	Kcnn3, Sk3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3).

MAGAA_HUMAN
NC score	0.009115 (rank : 268)	θ value	4.03905 (rank : 134)
Query Neighborhood Hits	175	Target Neighborhood Hits	82	Shared Neighborhood Hits	7
SwissProt Accessions	P43363	Gene names	MAGEA10, MAGE10
Domain Architecture
Description	Melanoma-associated antigen 10 (MAGE-10 antigen).

PRRX2_MOUSE
NC score	0.009111 (rank : 269)	θ value	1.06291 (rank : 90)
Query Neighborhood Hits	175	Target Neighborhood Hits	351	Shared Neighborhood Hits	6
SwissProt Accessions	Q06348, Q61651	Gene names	Prrx2, Prx2, S8
Domain Architecture
Description	Paired mesoderm homeobox protein 2 (PRX-2) (Homeobox protein S8).

B3A3_HUMAN
NC score	0.005544 (rank : 270)	θ value	6.88961 (rank : 154)
Query Neighborhood Hits	175	Target Neighborhood Hits	119	Shared Neighborhood Hits	4
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

FBN3_HUMAN
NC score	0.004568 (rank : 271)	θ value	4.03905 (rank : 132)
Query Neighborhood Hits	175	Target Neighborhood Hits	543	Shared Neighborhood Hits	4
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

MAGI1_MOUSE
NC score	0.004541 (rank : 272)	θ value	6.88961 (rank : 158)
Query Neighborhood Hits	175	Target Neighborhood Hits	403	Shared Neighborhood Hits	5
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

HSP74_HUMAN
NC score	0.004273 (rank : 273)	θ value	8.99809 (rank : 167)
Query Neighborhood Hits	175	Target Neighborhood Hits	154	Shared Neighborhood Hits	8
SwissProt Accessions	P34932, O95756	Gene names	HSPA4
Domain Architecture
Description	Heat shock 70 kDa protein 4 (Heat shock 70-related protein APG-2) (HSP70RY).

RXRB_MOUSE
NC score	0.002968 (rank : 274)	θ value	8.99809 (rank : 170)
Query Neighborhood Hits	175	Target Neighborhood Hits	230	Shared Neighborhood Hits	8
SwissProt Accessions	P28704, P33243	Gene names	Rxrb, Nr2b2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta) (MHC class I regulatory element-binding protein H-2RIIBP).

FRAS1_MOUSE
NC score	0.002856 (rank : 275)	θ value	6.88961 (rank : 156)
Query Neighborhood Hits	175	Target Neighborhood Hits	747	Shared Neighborhood Hits	5
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

RXRB_HUMAN
NC score	0.002642 (rank : 276)	θ value	8.99809 (rank : 169)
Query Neighborhood Hits	175	Target Neighborhood Hits	280	Shared Neighborhood Hits	7
SwissProt Accessions	P28702, P28703	Gene names	RXRB, NR2B2
Domain Architecture
Description	Retinoic acid receptor RXR-beta (Retinoid X receptor beta).

ZN687_MOUSE
NC score	0.002252 (rank : 277)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	175	Target Neighborhood Hits	913	Shared Neighborhood Hits	11
SwissProt Accessions	Q9D2D7, Q6PAP3, Q6ZPQ9	Gene names	Znf687, Kiaa1441, Zfp687
Domain Architecture	No domain graphic available
Description	Zinc finger protein 687.

SPEG_HUMAN
NC score	-0.001918 (rank : 278)	θ value	2.36792 (rank : 115)
Query Neighborhood Hits	175	Target Neighborhood Hits	1762	Shared Neighborhood Hits	13
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

TESK2_MOUSE
NC score	-0.003422 (rank : 279)	θ value	4.03905 (rank : 141)
Query Neighborhood Hits	175	Target Neighborhood Hits	833	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VCT9	Gene names	Tesk2
Domain Architecture
Description	Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2).

ZN287_MOUSE
NC score	-0.005133 (rank : 280)	θ value	6.88961 (rank : 162)
Query Neighborhood Hits	175	Target Neighborhood Hits	771	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EQB9	Gene names	Znf287, Skat2, Zfp287
Domain Architecture
Description	Zinc finger protein 287 (Zfp-287) (Zinc finger protein SKAT-2).