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Network neighborhood for query Sequence : NPAS2_HUMAN

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NPAS2_HUMAN
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CLOCK_HUMAN
θ value	0 (rank : 1)	NC score	0.968979 (rank : 3)
Query Neighborhood Hits	150	Target Neighborhood Hits	127	Shared Neighborhood Hits	68
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	0 (rank : 2)	NC score	0.967165 (rank : 4)
Query Neighborhood Hits	150	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

NPAS2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	150	Target Neighborhood Hits	150	Shared Neighborhood Hits	150
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	0 (rank : 4)	NC score	0.988447 (rank : 2)
Query Neighborhood Hits	150	Target Neighborhood Hits	132	Shared Neighborhood Hits	81
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

BMAL1_HUMAN
θ value	1.20211e-36 (rank : 5)	NC score	0.844131 (rank : 5)
Query Neighborhood Hits	150	Target Neighborhood Hits	115	Shared Neighborhood Hits	62
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	2.26708e-35 (rank : 6)	NC score	0.840258 (rank : 6)
Query Neighborhood Hits	150	Target Neighborhood Hits	121	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

ARNT_HUMAN
θ value	1.0531e-32 (rank : 7)	NC score	0.807856 (rank : 7)
Query Neighborhood Hits	150	Target Neighborhood Hits	109	Shared Neighborhood Hits	60
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	8.91499e-32 (rank : 8)	NC score	0.794288 (rank : 8)
Query Neighborhood Hits	150	Target Neighborhood Hits	213	Shared Neighborhood Hits	66
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

EPAS1_HUMAN
θ value	6.38894e-30 (rank : 9)	NC score	0.792996 (rank : 10)
Query Neighborhood Hits	150	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	1.4233e-29 (rank : 10)	NC score	0.789720 (rank : 12)
Query Neighborhood Hits	150	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_HUMAN
θ value	7.06379e-29 (rank : 11)	NC score	0.783999 (rank : 13)
Query Neighborhood Hits	150	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	1.47289e-26 (rank : 12)	NC score	0.781677 (rank : 14)
Query Neighborhood Hits	150	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

ARNT2_MOUSE
θ value	3.62785e-25 (rank : 13)	NC score	0.793339 (rank : 9)
Query Neighborhood Hits	150	Target Neighborhood Hits	115	Shared Neighborhood Hits	59
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
θ value	4.73814e-25 (rank : 14)	NC score	0.792793 (rank : 11)
Query Neighborhood Hits	150	Target Neighborhood Hits	109	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

SIM1_HUMAN
θ value	1.13037e-18 (rank : 15)	NC score	0.731785 (rank : 16)
Query Neighborhood Hits	150	Target Neighborhood Hits	62	Shared Neighborhood Hits	41
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	1.13037e-18 (rank : 16)	NC score	0.731920 (rank : 15)
Query Neighborhood Hits	150	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	5.60996e-18 (rank : 17)	NC score	0.727511 (rank : 17)
Query Neighborhood Hits	150	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	3.63628e-17 (rank : 18)	NC score	0.726641 (rank : 18)
Query Neighborhood Hits	150	Target Neighborhood Hits	75	Shared Neighborhood Hits	42
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

AHR_HUMAN
θ value	1.38178e-16 (rank : 19)	NC score	0.721429 (rank : 19)
Query Neighborhood Hits	150	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
θ value	8.95645e-16 (rank : 20)	NC score	0.712314 (rank : 20)
Query Neighborhood Hits	150	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NCOA1_MOUSE
θ value	8.95645e-16 (rank : 21)	NC score	0.628594 (rank : 25)
Query Neighborhood Hits	150	Target Neighborhood Hits	196	Shared Neighborhood Hits	51
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
θ value	1.99529e-15 (rank : 22)	NC score	0.623987 (rank : 26)
Query Neighborhood Hits	150	Target Neighborhood Hits	198	Shared Neighborhood Hits	46
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NPAS3_MOUSE
θ value	6.41864e-14 (rank : 23)	NC score	0.686872 (rank : 21)
Query Neighborhood Hits	150	Target Neighborhood Hits	103	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NCOA2_HUMAN
θ value	1.86753e-13 (rank : 24)	NC score	0.569581 (rank : 27)
Query Neighborhood Hits	150	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA2_MOUSE
θ value	3.18553e-13 (rank : 25)	NC score	0.568298 (rank : 29)
Query Neighborhood Hits	150	Target Neighborhood Hits	281	Shared Neighborhood Hits	37
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NPAS3_HUMAN
θ value	5.43371e-13 (rank : 26)	NC score	0.682649 (rank : 22)
Query Neighborhood Hits	150	Target Neighborhood Hits	81	Shared Neighborhood Hits	36
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

PER2_MOUSE
θ value	7.34386e-10 (rank : 27)	NC score	0.414964 (rank : 38)
Query Neighborhood Hits	150	Target Neighborhood Hits	325	Shared Neighborhood Hits	38
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER2_HUMAN
θ value	2.79066e-09 (rank : 28)	NC score	0.434540 (rank : 34)
Query Neighborhood Hits	150	Target Neighborhood Hits	170	Shared Neighborhood Hits	32
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER3_MOUSE
θ value	2.79066e-09 (rank : 29)	NC score	0.456176 (rank : 33)
Query Neighborhood Hits	150	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

NCOA3_HUMAN
θ value	3.64472e-09 (rank : 30)	NC score	0.569420 (rank : 28)
Query Neighborhood Hits	150	Target Neighborhood Hits	171	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

PER3_HUMAN
θ value	6.21693e-09 (rank : 31)	NC score	0.419036 (rank : 37)
Query Neighborhood Hits	150	Target Neighborhood Hits	479	Shared Neighborhood Hits	44
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

NPAS1_MOUSE
θ value	1.38499e-08 (rank : 32)	NC score	0.664367 (rank : 23)
Query Neighborhood Hits	150	Target Neighborhood Hits	63	Shared Neighborhood Hits	33
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
θ value	2.36244e-08 (rank : 33)	NC score	0.661296 (rank : 24)
Query Neighborhood Hits	150	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

PER1_HUMAN
θ value	4.0297e-08 (rank : 34)	NC score	0.427623 (rank : 35)
Query Neighborhood Hits	150	Target Neighborhood Hits	215	Shared Neighborhood Hits	37
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
θ value	5.26297e-08 (rank : 35)	NC score	0.423123 (rank : 36)
Query Neighborhood Hits	150	Target Neighborhood Hits	235	Shared Neighborhood Hits	40
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

NCOA3_MOUSE
θ value	2.61198e-07 (rank : 36)	NC score	0.531060 (rank : 30)
Query Neighborhood Hits	150	Target Neighborhood Hits	203	Shared Neighborhood Hits	38
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NPAS4_HUMAN
θ value	0.00020696 (rank : 37)	NC score	0.507368 (rank : 31)
Query Neighborhood Hits	150	Target Neighborhood Hits	214	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
θ value	0.000270298 (rank : 38)	NC score	0.491599 (rank : 32)
Query Neighborhood Hits	150	Target Neighborhood Hits	245	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

HNF1A_MOUSE
θ value	0.0113563 (rank : 39)	NC score	0.041654 (rank : 83)
Query Neighborhood Hits	150	Target Neighborhood Hits	212	Shared Neighborhood Hits	17
SwissProt Accessions	P22361	Gene names	Tcf1, Hnf-1, Hnf-1a, Hnf1a
Domain Architecture
Description	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1).

EMSY_HUMAN
θ value	0.0193708 (rank : 40)	NC score	0.087680 (rank : 63)
Query Neighborhood Hits	150	Target Neighborhood Hits	296	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

RUNX1_HUMAN
θ value	0.0252991 (rank : 41)	NC score	0.043345 (rank : 81)
Query Neighborhood Hits	150	Target Neighborhood Hits	94	Shared Neighborhood Hits	7
SwissProt Accessions	Q01196, O60472, O60473, O76047, O76089, Q13081, Q13755, Q13756, Q13757, Q13758, Q13759, Q15341, Q15343, Q16122, Q16284, Q16285, Q16286, Q16346, Q16347, Q92479	Gene names	RUNX1, AML1, CBFA2
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

ZIMP7_MOUSE
θ value	0.0252991 (rank : 42)	NC score	0.039672 (rank : 84)
Query Neighborhood Hits	150	Target Neighborhood Hits	566	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

RUNX1_MOUSE
θ value	0.0431538 (rank : 43)	NC score	0.041745 (rank : 82)
Query Neighborhood Hits	150	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

MYH9_HUMAN
θ value	0.0563607 (rank : 44)	NC score	0.024163 (rank : 96)
Query Neighborhood Hits	150	Target Neighborhood Hits	1762	Shared Neighborhood Hits	36
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
θ value	0.0736092 (rank : 45)	NC score	0.023462 (rank : 97)
Query Neighborhood Hits	150	Target Neighborhood Hits	1829	Shared Neighborhood Hits	33
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

EMSY_MOUSE
θ value	0.0961366 (rank : 46)	NC score	0.080939 (rank : 68)
Query Neighborhood Hits	150	Target Neighborhood Hits	294	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

NCOA6_HUMAN
θ value	0.125558 (rank : 47)	NC score	0.072939 (rank : 71)
Query Neighborhood Hits	150	Target Neighborhood Hits	1202	Shared Neighborhood Hits	60
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NCOA6_MOUSE
θ value	0.125558 (rank : 48)	NC score	0.082141 (rank : 67)
Query Neighborhood Hits	150	Target Neighborhood Hits	1076	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SON_HUMAN
θ value	0.163984 (rank : 49)	NC score	0.052450 (rank : 78)
Query Neighborhood Hits	150	Target Neighborhood Hits	1568	Shared Neighborhood Hits	58
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

US6NL_HUMAN
θ value	0.163984 (rank : 50)	NC score	0.028367 (rank : 88)
Query Neighborhood Hits	150	Target Neighborhood Hits	201	Shared Neighborhood Hits	12
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

CD248_HUMAN
θ value	0.21417 (rank : 51)	NC score	0.022363 (rank : 99)
Query Neighborhood Hits	150	Target Neighborhood Hits	679	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

MAML3_HUMAN
θ value	0.21417 (rank : 52)	NC score	0.065583 (rank : 74)
Query Neighborhood Hits	150	Target Neighborhood Hits	323	Shared Neighborhood Hits	23
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

TFE3_HUMAN
θ value	0.21417 (rank : 53)	NC score	0.177910 (rank : 39)
Query Neighborhood Hits	150	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

HES7_HUMAN
θ value	0.279714 (rank : 54)	NC score	0.096405 (rank : 61)
Query Neighborhood Hits	150	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MITF_HUMAN
θ value	0.279714 (rank : 55)	NC score	0.170197 (rank : 41)
Query Neighborhood Hits	150	Target Neighborhood Hits	113	Shared Neighborhood Hits	39
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	0.279714 (rank : 56)	NC score	0.171370 (rank : 40)
Query Neighborhood Hits	150	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

BHLH2_HUMAN
θ value	0.365318 (rank : 57)	NC score	0.111474 (rank : 55)
Query Neighborhood Hits	150	Target Neighborhood Hits	80	Shared Neighborhood Hits	33
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	0.365318 (rank : 58)	NC score	0.110609 (rank : 56)
Query Neighborhood Hits	150	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES7_MOUSE
θ value	0.365318 (rank : 59)	NC score	0.092084 (rank : 62)
Query Neighborhood Hits	150	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MLX_HUMAN
θ value	0.365318 (rank : 60)	NC score	0.160216 (rank : 42)
Query Neighborhood Hits	150	Target Neighborhood Hits	95	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	0.365318 (rank : 61)	NC score	0.159794 (rank : 43)
Query Neighborhood Hits	150	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TTLL5_MOUSE
θ value	0.365318 (rank : 62)	NC score	0.021006 (rank : 101)
Query Neighborhood Hits	150	Target Neighborhood Hits	150	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

WNK1_MOUSE
θ value	0.365318 (rank : 63)	NC score	0.008020 (rank : 142)
Query Neighborhood Hits	150	Target Neighborhood Hits	1179	Shared Neighborhood Hits	36
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

PO2F1_MOUSE
θ value	0.47712 (rank : 64)	NC score	0.012660 (rank : 126)
Query Neighborhood Hits	150	Target Neighborhood Hits	408	Shared Neighborhood Hits	12
SwissProt Accessions	P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6	Gene names	Pou2f1, Oct-1, Otf-1, Otf1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

SDC3_MOUSE
θ value	0.47712 (rank : 65)	NC score	0.039241 (rank : 85)
Query Neighborhood Hits	150	Target Neighborhood Hits	107	Shared Neighborhood Hits	11
SwissProt Accessions	Q64519, Q3UDD9, Q6ZQA4, Q7TQD4	Gene names	Sdc3, Kiaa0468
Domain Architecture
Description	Syndecan-3 precursor (SYND3).

USF1_HUMAN
θ value	0.47712 (rank : 66)	NC score	0.142897 (rank : 46)
Query Neighborhood Hits	150	Target Neighborhood Hits	70	Shared Neighborhood Hits	30
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	0.47712 (rank : 67)	NC score	0.142819 (rank : 47)
Query Neighborhood Hits	150	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

HCN1_MOUSE
θ value	0.813845 (rank : 68)	NC score	0.014261 (rank : 119)
Query Neighborhood Hits	150	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

MDC1_MOUSE
θ value	0.813845 (rank : 69)	NC score	0.027569 (rank : 89)
Query Neighborhood Hits	150	Target Neighborhood Hits	998	Shared Neighborhood Hits	38
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

ULK1_HUMAN
θ value	0.813845 (rank : 70)	NC score	-0.000603 (rank : 158)
Query Neighborhood Hits	150	Target Neighborhood Hits	1121	Shared Neighborhood Hits	12
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

USF2_HUMAN
θ value	0.813845 (rank : 71)	NC score	0.135239 (rank : 48)
Query Neighborhood Hits	150	Target Neighborhood Hits	155	Shared Neighborhood Hits	31
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

DACH1_HUMAN
θ value	1.06291 (rank : 72)	NC score	0.022404 (rank : 98)
Query Neighborhood Hits	150	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

DCC_MOUSE
θ value	1.06291 (rank : 73)	NC score	0.005681 (rank : 150)
Query Neighborhood Hits	150	Target Neighborhood Hits	896	Shared Neighborhood Hits	22
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

MYH10_HUMAN
θ value	1.06291 (rank : 74)	NC score	0.018510 (rank : 106)
Query Neighborhood Hits	150	Target Neighborhood Hits	1620	Shared Neighborhood Hits	28
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

RN165_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.018460 (rank : 108)
Query Neighborhood Hits	150	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZSG1	Gene names	RNF165
Domain Architecture	No domain graphic available
Description	RING finger protein 165.

TULP4_HUMAN
θ value	1.06291 (rank : 76)	NC score	0.026480 (rank : 91)
Query Neighborhood Hits	150	Target Neighborhood Hits	426	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

DCP1A_HUMAN
θ value	1.38821 (rank : 77)	NC score	0.046854 (rank : 80)
Query Neighborhood Hits	150	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

GAK2_HUMAN
θ value	1.38821 (rank : 78)	NC score	0.015991 (rank : 116)
Query Neighborhood Hits	150	Target Neighborhood Hits	406	Shared Neighborhood Hits	17
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

KIF17_HUMAN
θ value	1.38821 (rank : 79)	NC score	0.008592 (rank : 139)
Query Neighborhood Hits	150	Target Neighborhood Hits	365	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P2E2, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411	Gene names	KIF17, KIAA1405, KIF3X
Domain Architecture
Description	Kinesin-like protein KIF17 (KIF3-related motor protein).

MLL3_HUMAN
θ value	1.38821 (rank : 80)	NC score	0.033331 (rank : 86)
Query Neighborhood Hits	150	Target Neighborhood Hits	1644	Shared Neighborhood Hits	51
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

MYH10_MOUSE
θ value	1.38821 (rank : 81)	NC score	0.018268 (rank : 109)
Query Neighborhood Hits	150	Target Neighborhood Hits	1612	Shared Neighborhood Hits	29
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

USF2_MOUSE
θ value	1.38821 (rank : 82)	NC score	0.127512 (rank : 54)
Query Neighborhood Hits	150	Target Neighborhood Hits	173	Shared Neighborhood Hits	30
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

ADA12_MOUSE
θ value	1.81305 (rank : 83)	NC score	0.004716 (rank : 151)
Query Neighborhood Hits	150	Target Neighborhood Hits	474	Shared Neighborhood Hits	14
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ATOH1_HUMAN
θ value	1.81305 (rank : 84)	NC score	0.016670 (rank : 114)
Query Neighborhood Hits	150	Target Neighborhood Hits	97	Shared Neighborhood Hits	5
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

BHLH3_HUMAN
θ value	1.81305 (rank : 85)	NC score	0.110389 (rank : 57)
Query Neighborhood Hits	150	Target Neighborhood Hits	106	Shared Neighborhood Hits	33
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	1.81305 (rank : 86)	NC score	0.108672 (rank : 58)
Query Neighborhood Hits	150	Target Neighborhood Hits	70	Shared Neighborhood Hits	32
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BRCA1_MOUSE
θ value	1.81305 (rank : 87)	NC score	0.010432 (rank : 134)
Query Neighborhood Hits	150	Target Neighborhood Hits	436	Shared Neighborhood Hits	8
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

MUC5B_HUMAN
θ value	1.81305 (rank : 88)	NC score	0.026973 (rank : 90)
Query Neighborhood Hits	150	Target Neighborhood Hits	1020	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

RANB3_HUMAN
θ value	1.81305 (rank : 89)	NC score	0.018471 (rank : 107)
Query Neighborhood Hits	150	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H6Z4, O60405, O75759, O75760, Q9BT47, Q9UG74	Gene names	RANBP3
Domain Architecture	No domain graphic available
Description	Ran-binding protein 3 (RanBP3).

TAF3_HUMAN
θ value	1.81305 (rank : 90)	NC score	0.018600 (rank : 104)
Query Neighborhood Hits	150	Target Neighborhood Hits	568	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

DLX5_MOUSE
θ value	2.36792 (rank : 91)	NC score	0.003100 (rank : 154)
Query Neighborhood Hits	150	Target Neighborhood Hits	434	Shared Neighborhood Hits	5
SwissProt Accessions	P70396, O54876, O54877, O54878, Q9JJ45	Gene names	Dlx5
Domain Architecture
Description	Homeobox protein DLX-5.

MYH11_HUMAN
θ value	2.36792 (rank : 92)	NC score	0.017515 (rank : 112)
Query Neighborhood Hits	150	Target Neighborhood Hits	1806	Shared Neighborhood Hits	29
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
θ value	2.36792 (rank : 93)	NC score	0.017678 (rank : 111)
Query Neighborhood Hits	150	Target Neighborhood Hits	1777	Shared Neighborhood Hits	28
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

KIF17_MOUSE
θ value	3.0926 (rank : 94)	NC score	0.009807 (rank : 137)
Query Neighborhood Hits	150	Target Neighborhood Hits	452	Shared Neighborhood Hits	18
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

PI51A_HUMAN
θ value	3.0926 (rank : 95)	NC score	0.008476 (rank : 140)
Query Neighborhood Hits	150	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

RFFL_HUMAN
θ value	3.0926 (rank : 96)	NC score	0.011680 (rank : 131)
Query Neighborhood Hits	150	Target Neighborhood Hits	175	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

TARA_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.024266 (rank : 95)
Query Neighborhood Hits	150	Target Neighborhood Hits	1626	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TFEB_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.150564 (rank : 45)
Query Neighborhood Hits	150	Target Neighborhood Hits	111	Shared Neighborhood Hits	33
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	3.0926 (rank : 99)	NC score	0.151452 (rank : 44)
Query Neighborhood Hits	150	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TIMD1_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.021785 (rank : 100)
Query Neighborhood Hits	150	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

AMOT_HUMAN
θ value	4.03905 (rank : 101)	NC score	0.016391 (rank : 115)
Query Neighborhood Hits	150	Target Neighborhood Hits	712	Shared Neighborhood Hits	23
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

APOB_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.020144 (rank : 102)
Query Neighborhood Hits	150	Target Neighborhood Hits	202	Shared Neighborhood Hits	9
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

CDK8_HUMAN
θ value	4.03905 (rank : 103)	NC score	-0.001377 (rank : 161)
Query Neighborhood Hits	150	Target Neighborhood Hits	831	Shared Neighborhood Hits	8
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

GAK5_HUMAN
θ value	4.03905 (rank : 104)	NC score	0.014640 (rank : 118)
Query Neighborhood Hits	150	Target Neighborhood Hits	429	Shared Neighborhood Hits	19
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GMEB2_HUMAN
θ value	4.03905 (rank : 105)	NC score	0.011072 (rank : 133)
Query Neighborhood Hits	150	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKD1, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9ULF1	Gene names	GMEB2, KIAA1269
Domain Architecture
Description	Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (Parvovirus initiation factor p79) (PIF p79) (DNA-binding protein p79PIF).

CBL_MOUSE
θ value	5.27518 (rank : 106)	NC score	0.007241 (rank : 146)
Query Neighborhood Hits	150	Target Neighborhood Hits	426	Shared Neighborhood Hits	15
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

CO039_MOUSE
θ value	5.27518 (rank : 107)	NC score	0.017184 (rank : 113)
Query Neighborhood Hits	150	Target Neighborhood Hits	445	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

HAX1_MOUSE
θ value	5.27518 (rank : 108)	NC score	0.013808 (rank : 122)
Query Neighborhood Hits	150	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	O35387	Gene names	Hax1, Hs1bp1
Domain Architecture	No domain graphic available
Description	HS1-associating protein X-1 (HAX-1) (HS1-binding protein).

HGS_HUMAN
θ value	5.27518 (rank : 109)	NC score	0.025434 (rank : 94)
Query Neighborhood Hits	150	Target Neighborhood Hits	517	Shared Neighborhood Hits	37
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

K0240_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.014151 (rank : 120)
Query Neighborhood Hits	150	Target Neighborhood Hits	211	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHH5	Gene names	Kiaa0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

LIPA1_HUMAN
θ value	5.27518 (rank : 111)	NC score	0.006245 (rank : 149)
Query Neighborhood Hits	150	Target Neighborhood Hits	1294	Shared Neighborhood Hits	28
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

RFX1_HUMAN
θ value	5.27518 (rank : 112)	NC score	0.018048 (rank : 110)
Query Neighborhood Hits	150	Target Neighborhood Hits	256	Shared Neighborhood Hits	26
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

STK39_MOUSE
θ value	5.27518 (rank : 113)	NC score	-0.002592 (rank : 162)
Query Neighborhood Hits	150	Target Neighborhood Hits	915	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

T22D2_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.025495 (rank : 93)
Query Neighborhood Hits	150	Target Neighborhood Hits	250	Shared Neighborhood Hits	25
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TAF1C_MOUSE
θ value	5.27518 (rank : 115)	NC score	0.018729 (rank : 103)
Query Neighborhood Hits	150	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDZ2, P97359, Q3U3B6, Q8BN54	Gene names	Taf1c
Domain Architecture	No domain graphic available
Description	TATA box-binding protein-associated factor, RNA polymerase I, subunit C (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (TBP-associated factor RNA polymerase I 95 kDa) (TAFI95).

TCFL5_HUMAN
θ value	5.27518 (rank : 116)	NC score	0.129367 (rank : 52)
Query Neighborhood Hits	150	Target Neighborhood Hits	43	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

XKR5_MOUSE
θ value	5.27518 (rank : 117)	NC score	0.009379 (rank : 138)
Query Neighborhood Hits	150	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q5GH66	Gene names	Xkr5, Xrg5
Domain Architecture	No domain graphic available
Description	XK-related protein 5.

ZN645_HUMAN
θ value	5.27518 (rank : 118)	NC score	0.029317 (rank : 87)
Query Neighborhood Hits	150	Target Neighborhood Hits	265	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

GAK6_HUMAN
θ value	6.88961 (rank : 119)	NC score	0.013899 (rank : 121)
Query Neighborhood Hits	150	Target Neighborhood Hits	392	Shared Neighborhood Hits	16
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HES5_MOUSE
θ value	6.88961 (rank : 120)	NC score	0.106422 (rank : 59)
Query Neighborhood Hits	150	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY1_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.128273 (rank : 53)
Query Neighborhood Hits	150	Target Neighborhood Hits	82	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	6.88961 (rank : 122)	NC score	0.133491 (rank : 49)
Query Neighborhood Hits	150	Target Neighborhood Hits	69	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

MCM6_MOUSE
θ value	6.88961 (rank : 123)	NC score	0.007353 (rank : 144)
Query Neighborhood Hits	150	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	P97311, Q80YQ7	Gene names	Mcm6, Mcmd6, Mis5
Domain Architecture
Description	DNA replication licensing factor MCM6 (Mis5 homolog).

MK07_MOUSE
θ value	6.88961 (rank : 124)	NC score	-0.001179 (rank : 160)
Query Neighborhood Hits	150	Target Neighborhood Hits	1054	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

MYCL1_HUMAN
θ value	6.88961 (rank : 125)	NC score	0.078269 (rank : 69)
Query Neighborhood Hits	150	Target Neighborhood Hits	146	Shared Neighborhood Hits	31
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	6.88961 (rank : 126)	NC score	0.082784 (rank : 66)
Query Neighborhood Hits	150	Target Neighborhood Hits	123	Shared Neighborhood Hits	29
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

POGK_MOUSE
θ value	6.88961 (rank : 127)	NC score	0.001875 (rank : 157)
Query Neighborhood Hits	150	Target Neighborhood Hits	257	Shared Neighborhood Hits	2
SwissProt Accessions	Q80TC5, Q8BPJ3, Q8C887	Gene names	Pogk, Kiaa1513
Domain Architecture
Description	Pogo transposable element with KRAB domain.

RUFY1_HUMAN
θ value	6.88961 (rank : 128)	NC score	0.012508 (rank : 128)
Query Neighborhood Hits	150	Target Neighborhood Hits	848	Shared Neighborhood Hits	17
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

SDC3_HUMAN
θ value	6.88961 (rank : 129)	NC score	0.025988 (rank : 92)
Query Neighborhood Hits	150	Target Neighborhood Hits	103	Shared Neighborhood Hits	11
SwissProt Accessions	O75056, Q5T1Z6, Q5T1Z7, Q96CT3, Q96PR8	Gene names	SDC3, KIAA0468
Domain Architecture
Description	Syndecan-3 (SYND3).

TITIN_HUMAN
θ value	6.88961 (rank : 130)	NC score	-0.000892 (rank : 159)
Query Neighborhood Hits	150	Target Neighborhood Hits	2923	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

TTLL4_HUMAN
θ value	6.88961 (rank : 131)	NC score	0.012040 (rank : 130)
Query Neighborhood Hits	150	Target Neighborhood Hits	79	Shared Neighborhood Hits	6
SwissProt Accessions	Q14679, Q8WW29	Gene names	TTLL4, KIAA0173
Domain Architecture
Description	Tubulin--tyrosine ligase-like protein 4.

WNK2_HUMAN
θ value	6.88961 (rank : 132)	NC score	0.007259 (rank : 145)
Query Neighborhood Hits	150	Target Neighborhood Hits	1407	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ADA19_HUMAN
θ value	8.99809 (rank : 133)	NC score	0.003874 (rank : 152)
Query Neighborhood Hits	150	Target Neighborhood Hits	381	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

AKAP2_HUMAN
θ value	8.99809 (rank : 134)	NC score	0.010278 (rank : 135)
Query Neighborhood Hits	150	Target Neighborhood Hits	507	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

AMOL1_MOUSE
θ value	8.99809 (rank : 135)	NC score	0.011306 (rank : 132)
Query Neighborhood Hits	150	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

BRD4_HUMAN
θ value	8.99809 (rank : 136)	NC score	0.018576 (rank : 105)
Query Neighborhood Hits	150	Target Neighborhood Hits	851	Shared Neighborhood Hits	44
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CEP63_HUMAN
θ value	8.99809 (rank : 137)	NC score	0.008023 (rank : 141)
Query Neighborhood Hits	150	Target Neighborhood Hits	1005	Shared Neighborhood Hits	20
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CIC_HUMAN
θ value	8.99809 (rank : 138)	NC score	0.015117 (rank : 117)
Query Neighborhood Hits	150	Target Neighborhood Hits	992	Shared Neighborhood Hits	50
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

ELF1_MOUSE
θ value	8.99809 (rank : 139)	NC score	0.006854 (rank : 147)
Query Neighborhood Hits	150	Target Neighborhood Hits	139	Shared Neighborhood Hits	12
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

GAK11_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.013597 (rank : 124)
Query Neighborhood Hits	150	Target Neighborhood Hits	409	Shared Neighborhood Hits	17
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK12_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.013529 (rank : 125)
Query Neighborhood Hits	150	Target Neighborhood Hits	374	Shared Neighborhood Hits	15
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.013602 (rank : 123)
Query Neighborhood Hits	150	Target Neighborhood Hits	415	Shared Neighborhood Hits	17
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GOGA5_MOUSE
θ value	8.99809 (rank : 143)	NC score	0.007998 (rank : 143)
Query Neighborhood Hits	150	Target Neighborhood Hits	1434	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

IF35_HUMAN
θ value	8.99809 (rank : 144)	NC score	0.009867 (rank : 136)
Query Neighborhood Hits	150	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

IWS1_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.003278 (rank : 153)
Query Neighborhood Hits	150	Target Neighborhood Hits	1241	Shared Neighborhood Hits	22
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

LTB1L_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.002560 (rank : 155)
Query Neighborhood Hits	150	Target Neighborhood Hits	553	Shared Neighborhood Hits	13
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_HUMAN
θ value	8.99809 (rank : 147)	NC score	0.002506 (rank : 156)
Query Neighborhood Hits	150	Target Neighborhood Hits	502	Shared Neighborhood Hits	11
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

MUCEN_HUMAN
θ value	8.99809 (rank : 148)	NC score	0.012657 (rank : 127)
Query Neighborhood Hits	150	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULC0, Q8NEY5, Q8WWE7, Q9NRM8	Gene names	EMCN, EMCN2. MUC14
Domain Architecture	No domain graphic available
Description	Endomucin precursor (Endomucin-2) (Gastric cancer antigen Ga34).

NMNA1_MOUSE
θ value	8.99809 (rank : 149)	NC score	0.006534 (rank : 148)
Query Neighborhood Hits	150	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPA7, Q6B504	Gene names	Nmnat1, D4Cole1e, Nmnat
Domain Architecture
Description	Nicotinamide mononucleotide adenylyltransferase 1 (EC 2.7.7.1) (NMN adenylyltransferase 1).

TEKT2_HUMAN
θ value	8.99809 (rank : 150)	NC score	0.012407 (rank : 129)
Query Neighborhood Hits	150	Target Neighborhood Hits	197	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UIF3, O60638	Gene names	TEKT2
Domain Architecture
Description	Tektin-2 (Testicular tektin) (Tektin-t) (Testicular tektin B1-like protein) (Tektin-B1) (TEKTB1).

HES3_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.070983 (rank : 73)
Query Neighborhood Hits	150	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES4_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.055530 (rank : 75)
Query Neighborhood Hits	150	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HEY2_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.132357 (rank : 50)
Query Neighborhood Hits	150	Target Neighborhood Hits	77	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	θ > 10 (rank : 154)	NC score	0.130818 (rank : 51)
Query Neighborhood Hits	150	Target Neighborhood Hits	80	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MAD4_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.052697 (rank : 76)
Query Neighborhood Hits	150	Target Neighborhood Hits	94	Shared Neighborhood Hits	25
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAX_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.072109 (rank : 72)
Query Neighborhood Hits	150	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.083968 (rank : 65)
Query Neighborhood Hits	150	Target Neighborhood Hits	139	Shared Neighborhood Hits	32
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MUC7_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.050342 (rank : 79)
Query Neighborhood Hits	150	Target Neighborhood Hits	538	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

PCQAP_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.052464 (rank : 77)
Query Neighborhood Hits	150	Target Neighborhood Hits	549	Shared Neighborhood Hits	40
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

SRBP1_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.097196 (rank : 60)
Query Neighborhood Hits	150	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.087017 (rank : 64)
Query Neighborhood Hits	150	Target Neighborhood Hits	384	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.077100 (rank : 70)
Query Neighborhood Hits	150	Target Neighborhood Hits	133	Shared Neighborhood Hits	34
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

Hits sorted by NC score

NPAS2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	150	Target Neighborhood Hits	150	Shared Neighborhood Hits	150
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.988447 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	150	Target Neighborhood Hits	132	Shared Neighborhood Hits	81
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

CLOCK_HUMAN
NC score	0.968979 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	150	Target Neighborhood Hits	127	Shared Neighborhood Hits	68
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.967165 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	150	Target Neighborhood Hits	148	Shared Neighborhood Hits	72
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

BMAL1_HUMAN
NC score	0.844131 (rank : 5)	θ value	1.20211e-36 (rank : 5)
Query Neighborhood Hits	150	Target Neighborhood Hits	115	Shared Neighborhood Hits	62
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.840258 (rank : 6)	θ value	2.26708e-35 (rank : 6)
Query Neighborhood Hits	150	Target Neighborhood Hits	121	Shared Neighborhood Hits	62
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

ARNT_HUMAN
NC score	0.807856 (rank : 7)	θ value	1.0531e-32 (rank : 7)
Query Neighborhood Hits	150	Target Neighborhood Hits	109	Shared Neighborhood Hits	60
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.794288 (rank : 8)	θ value	8.91499e-32 (rank : 8)
Query Neighborhood Hits	150	Target Neighborhood Hits	213	Shared Neighborhood Hits	66
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_MOUSE
NC score	0.793339 (rank : 9)	θ value	3.62785e-25 (rank : 13)
Query Neighborhood Hits	150	Target Neighborhood Hits	115	Shared Neighborhood Hits	59
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

EPAS1_HUMAN
NC score	0.792996 (rank : 10)	θ value	6.38894e-30 (rank : 9)
Query Neighborhood Hits	150	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

ARNT2_HUMAN
NC score	0.792793 (rank : 11)	θ value	4.73814e-25 (rank : 14)
Query Neighborhood Hits	150	Target Neighborhood Hits	109	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

EPAS1_MOUSE
NC score	0.789720 (rank : 12)	θ value	1.4233e-29 (rank : 10)
Query Neighborhood Hits	150	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_HUMAN
NC score	0.783999 (rank : 13)	θ value	7.06379e-29 (rank : 11)
Query Neighborhood Hits	150	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
NC score	0.781677 (rank : 14)	θ value	1.47289e-26 (rank : 12)
Query Neighborhood Hits	150	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

SIM1_MOUSE
NC score	0.731920 (rank : 15)	θ value	1.13037e-18 (rank : 16)
Query Neighborhood Hits	150	Target Neighborhood Hits	69	Shared Neighborhood Hits	43
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM1_HUMAN
NC score	0.731785 (rank : 16)	θ value	1.13037e-18 (rank : 15)
Query Neighborhood Hits	150	Target Neighborhood Hits	62	Shared Neighborhood Hits	41
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM2_HUMAN
NC score	0.727511 (rank : 17)	θ value	5.60996e-18 (rank : 17)
Query Neighborhood Hits	150	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
NC score	0.726641 (rank : 18)	θ value	3.63628e-17 (rank : 18)
Query Neighborhood Hits	150	Target Neighborhood Hits	75	Shared Neighborhood Hits	42
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

AHR_HUMAN
NC score	0.721429 (rank : 19)	θ value	1.38178e-16 (rank : 19)
Query Neighborhood Hits	150	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
NC score	0.712314 (rank : 20)	θ value	8.95645e-16 (rank : 20)
Query Neighborhood Hits	150	Target Neighborhood Hits	55	Shared Neighborhood Hits	34
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NPAS3_MOUSE
NC score	0.686872 (rank : 21)	θ value	6.41864e-14 (rank : 23)
Query Neighborhood Hits	150	Target Neighborhood Hits	103	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_HUMAN
NC score	0.682649 (rank : 22)	θ value	5.43371e-13 (rank : 26)
Query Neighborhood Hits	150	Target Neighborhood Hits	81	Shared Neighborhood Hits	36
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS1_MOUSE
NC score	0.664367 (rank : 23)	θ value	1.38499e-08 (rank : 32)
Query Neighborhood Hits	150	Target Neighborhood Hits	63	Shared Neighborhood Hits	33
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS1_HUMAN
NC score	0.661296 (rank : 24)	θ value	2.36244e-08 (rank : 33)
Query Neighborhood Hits	150	Target Neighborhood Hits	77	Shared Neighborhood Hits	35
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NCOA1_MOUSE
NC score	0.628594 (rank : 25)	θ value	8.95645e-16 (rank : 21)
Query Neighborhood Hits	150	Target Neighborhood Hits	196	Shared Neighborhood Hits	51
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.623987 (rank : 26)	θ value	1.99529e-15 (rank : 22)
Query Neighborhood Hits	150	Target Neighborhood Hits	198	Shared Neighborhood Hits	46
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA2_HUMAN
NC score	0.569581 (rank : 27)	θ value	1.86753e-13 (rank : 24)
Query Neighborhood Hits	150	Target Neighborhood Hits	281	Shared Neighborhood Hits	40
SwissProt Accessions	Q15596	Gene names	NCOA2, TIF2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2).

NCOA3_HUMAN
NC score	0.569420 (rank : 28)	θ value	3.64472e-09 (rank : 30)
Query Neighborhood Hits	150	Target Neighborhood Hits	171	Shared Neighborhood Hits	42
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NCOA2_MOUSE
NC score	0.568298 (rank : 29)	θ value	3.18553e-13 (rank : 25)
Query Neighborhood Hits	150	Target Neighborhood Hits	281	Shared Neighborhood Hits	37
SwissProt Accessions	Q61026, O09001, P97759	Gene names	Ncoa2, Grip1, Tif2
Domain Architecture
Description	Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1).

NCOA3_MOUSE
NC score	0.531060 (rank : 30)	θ value	2.61198e-07 (rank : 36)
Query Neighborhood Hits	150	Target Neighborhood Hits	203	Shared Neighborhood Hits	38
SwissProt Accessions	O09000, Q9CRD5	Gene names	Ncoa3, Aib1, Pcip, Rac3, Tram1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP- interacting protein) (p/CIP) (pCIP).

NPAS4_HUMAN
NC score	0.507368 (rank : 31)	θ value	0.00020696 (rank : 37)
Query Neighborhood Hits	150	Target Neighborhood Hits	214	Shared Neighborhood Hits	44
SwissProt Accessions	Q8IUM7, Q8N8S5, Q8N9Q9	Gene names	NPAS4, NXF
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF).

NPAS4_MOUSE
NC score	0.491599 (rank : 32)	θ value	0.000270298 (rank : 38)
Query Neighborhood Hits	150	Target Neighborhood Hits	245	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

PER3_MOUSE
NC score	0.456176 (rank : 33)	θ value	2.79066e-09 (rank : 29)
Query Neighborhood Hits	150	Target Neighborhood Hits	85	Shared Neighborhood Hits	27
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PER2_HUMAN
NC score	0.434540 (rank : 34)	θ value	2.79066e-09 (rank : 28)
Query Neighborhood Hits	150	Target Neighborhood Hits	170	Shared Neighborhood Hits	32
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER1_HUMAN
NC score	0.427623 (rank : 35)	θ value	4.0297e-08 (rank : 34)
Query Neighborhood Hits	150	Target Neighborhood Hits	215	Shared Neighborhood Hits	37
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PER1_MOUSE
NC score	0.423123 (rank : 36)	θ value	5.26297e-08 (rank : 35)
Query Neighborhood Hits	150	Target Neighborhood Hits	235	Shared Neighborhood Hits	40
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PER3_HUMAN
NC score	0.419036 (rank : 37)	θ value	6.21693e-09 (rank : 31)
Query Neighborhood Hits	150	Target Neighborhood Hits	479	Shared Neighborhood Hits	44
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PER2_MOUSE
NC score	0.414964 (rank : 38)	θ value	7.34386e-10 (rank : 27)
Query Neighborhood Hits	150	Target Neighborhood Hits	325	Shared Neighborhood Hits	38
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

TFE3_HUMAN
NC score	0.177910 (rank : 39)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	150	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_MOUSE
NC score	0.171370 (rank : 40)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	150	Target Neighborhood Hits	115	Shared Neighborhood Hits	38
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_HUMAN
NC score	0.170197 (rank : 41)	θ value	0.279714 (rank : 55)
Query Neighborhood Hits	150	Target Neighborhood Hits	113	Shared Neighborhood Hits	39
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
NC score	0.160216 (rank : 42)	θ value	0.365318 (rank : 60)
Query Neighborhood Hits	150	Target Neighborhood Hits	95	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
NC score	0.159794 (rank : 43)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	150	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

TFEB_MOUSE
NC score	0.151452 (rank : 44)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	150	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.150564 (rank : 45)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	150	Target Neighborhood Hits	111	Shared Neighborhood Hits	33
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

USF1_HUMAN
NC score	0.142897 (rank : 46)	θ value	0.47712 (rank : 66)
Query Neighborhood Hits	150	Target Neighborhood Hits	70	Shared Neighborhood Hits	30
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.142819 (rank : 47)	θ value	0.47712 (rank : 67)
Query Neighborhood Hits	150	Target Neighborhood Hits	71	Shared Neighborhood Hits	30
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
NC score	0.135239 (rank : 48)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	150	Target Neighborhood Hits	155	Shared Neighborhood Hits	31
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

HEY1_MOUSE
NC score	0.133491 (rank : 49)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	150	Target Neighborhood Hits	69	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
NC score	0.132357 (rank : 50)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	150	Target Neighborhood Hits	77	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.130818 (rank : 51)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	150	Target Neighborhood Hits	80	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

TCFL5_HUMAN
NC score	0.129367 (rank : 52)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	150	Target Neighborhood Hits	43	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

HEY1_HUMAN
NC score	0.128273 (rank : 53)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	150	Target Neighborhood Hits	82	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

USF2_MOUSE
NC score	0.127512 (rank : 54)	θ value	1.38821 (rank : 82)
Query Neighborhood Hits	150	Target Neighborhood Hits	173	Shared Neighborhood Hits	30
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

BHLH2_HUMAN
NC score	0.111474 (rank : 55)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	150	Target Neighborhood Hits	80	Shared Neighborhood Hits	33
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.110609 (rank : 56)	θ value	0.365318 (rank : 58)
Query Neighborhood Hits	150	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_HUMAN
NC score	0.110389 (rank : 57)	θ value	1.81305 (rank : 85)
Query Neighborhood Hits	150	Target Neighborhood Hits	106	Shared Neighborhood Hits	33
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.108672 (rank : 58)	θ value	1.81305 (rank : 86)
Query Neighborhood Hits	150	Target Neighborhood Hits	70	Shared Neighborhood Hits	32
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

HES5_MOUSE
NC score	0.106422 (rank : 59)	θ value	6.88961 (rank : 120)
Query Neighborhood Hits	150	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

SRBP1_HUMAN
NC score	0.097196 (rank : 60)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	150	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

HES7_HUMAN
NC score	0.096405 (rank : 61)	θ value	0.279714 (rank : 54)
Query Neighborhood Hits	150	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.092084 (rank : 62)	θ value	0.365318 (rank : 59)
Query Neighborhood Hits	150	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

EMSY_HUMAN
NC score	0.087680 (rank : 63)	θ value	0.0193708 (rank : 40)
Query Neighborhood Hits	150	Target Neighborhood Hits	296	Shared Neighborhood Hits	22
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

SRBP1_MOUSE
NC score	0.087017 (rank : 64)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	150	Target Neighborhood Hits	384	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAX_MOUSE
NC score	0.083968 (rank : 65)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	150	Target Neighborhood Hits	139	Shared Neighborhood Hits	32
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MYCL1_MOUSE
NC score	0.082784 (rank : 66)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	150	Target Neighborhood Hits	123	Shared Neighborhood Hits	29
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

NCOA6_MOUSE
NC score	0.082141 (rank : 67)	θ value	0.125558 (rank : 48)
Query Neighborhood Hits	150	Target Neighborhood Hits	1076	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

EMSY_MOUSE
NC score	0.080939 (rank : 68)	θ value	0.0961366 (rank : 46)
Query Neighborhood Hits	150	Target Neighborhood Hits	294	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

MYCL1_HUMAN
NC score	0.078269 (rank : 69)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	150	Target Neighborhood Hits	146	Shared Neighborhood Hits	31
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

SRBP2_HUMAN
NC score	0.077100 (rank : 70)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	150	Target Neighborhood Hits	133	Shared Neighborhood Hits	34
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

NCOA6_HUMAN
NC score	0.072939 (rank : 71)	θ value	0.125558 (rank : 47)
Query Neighborhood Hits	150	Target Neighborhood Hits	1202	Shared Neighborhood Hits	60
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

MAX_HUMAN
NC score	0.072109 (rank : 72)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	150	Target Neighborhood Hits	125	Shared Neighborhood Hits	31
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

HES3_MOUSE
NC score	0.070983 (rank : 73)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	150	Target Neighborhood Hits	38	Shared Neighborhood Hits	15
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

MAML3_HUMAN
NC score	0.065583 (rank : 74)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	150	Target Neighborhood Hits	323	Shared Neighborhood Hits	23
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

HES4_HUMAN
NC score	0.055530 (rank : 75)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	150	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MAD4_HUMAN
NC score	0.052697 (rank : 76)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	150	Target Neighborhood Hits	94	Shared Neighborhood Hits	25
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

PCQAP_HUMAN
NC score	0.052464 (rank : 77)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	150	Target Neighborhood Hits	549	Shared Neighborhood Hits	40
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

SON_HUMAN
NC score	0.052450 (rank : 78)	θ value	0.163984 (rank : 49)
Query Neighborhood Hits	150	Target Neighborhood Hits	1568	Shared Neighborhood Hits	58
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

MUC7_HUMAN
NC score	0.050342 (rank : 79)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	150	Target Neighborhood Hits	538	Shared Neighborhood Hits	35
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

DCP1A_HUMAN
NC score	0.046854 (rank : 80)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	150	Target Neighborhood Hits	228	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

RUNX1_HUMAN
NC score	0.043345 (rank : 81)	θ value	0.0252991 (rank : 41)
Query Neighborhood Hits	150	Target Neighborhood Hits	94	Shared Neighborhood Hits	7
SwissProt Accessions	Q01196, O60472, O60473, O76047, O76089, Q13081, Q13755, Q13756, Q13757, Q13758, Q13759, Q15341, Q15343, Q16122, Q16284, Q16285, Q16286, Q16346, Q16347, Q92479	Gene names	RUNX1, AML1, CBFA2
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

RUNX1_MOUSE
NC score	0.041745 (rank : 82)	θ value	0.0431538 (rank : 43)
Query Neighborhood Hits	150	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q03347, O08598, Q62049, Q9ESB9, Q9ET65	Gene names	Runx1, Aml1, Cbfa2, Pebp2ab
Domain Architecture
Description	Runt-related transcription factor 1 (Core-binding factor, alpha 2 subunit) (CBF-alpha 2) (Acute myeloid leukemia 1 protein) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEBP2-alpha B) (PEA2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit).

HNF1A_MOUSE
NC score	0.041654 (rank : 83)	θ value	0.0113563 (rank : 39)
Query Neighborhood Hits	150	Target Neighborhood Hits	212	Shared Neighborhood Hits	17
SwissProt Accessions	P22361	Gene names	Tcf1, Hnf-1, Hnf-1a, Hnf1a
Domain Architecture
Description	Hepatocyte nuclear factor 1-alpha (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1).

ZIMP7_MOUSE
NC score	0.039672 (rank : 84)	θ value	0.0252991 (rank : 42)
Query Neighborhood Hits	150	Target Neighborhood Hits	566	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

SDC3_MOUSE
NC score	0.039241 (rank : 85)	θ value	0.47712 (rank : 65)
Query Neighborhood Hits	150	Target Neighborhood Hits	107	Shared Neighborhood Hits	11
SwissProt Accessions	Q64519, Q3UDD9, Q6ZQA4, Q7TQD4	Gene names	Sdc3, Kiaa0468
Domain Architecture
Description	Syndecan-3 precursor (SYND3).

MLL3_HUMAN
NC score	0.033331 (rank : 86)	θ value	1.38821 (rank : 80)
Query Neighborhood Hits	150	Target Neighborhood Hits	1644	Shared Neighborhood Hits	51
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ZN645_HUMAN
NC score	0.029317 (rank : 87)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	150	Target Neighborhood Hits	265	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

US6NL_HUMAN
NC score	0.028367 (rank : 88)	θ value	0.163984 (rank : 50)
Query Neighborhood Hits	150	Target Neighborhood Hits	201	Shared Neighborhood Hits	12
SwissProt Accessions	Q92738, Q15400, Q7L0K9	Gene names	USP6NL, KIAA0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).

MDC1_MOUSE
NC score	0.027569 (rank : 89)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	150	Target Neighborhood Hits	998	Shared Neighborhood Hits	38
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MUC5B_HUMAN
NC score	0.026973 (rank : 90)	θ value	1.81305 (rank : 88)
Query Neighborhood Hits	150	Target Neighborhood Hits	1020	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

TULP4_HUMAN
NC score	0.026480 (rank : 91)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	150	Target Neighborhood Hits	426	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

SDC3_HUMAN
NC score	0.025988 (rank : 92)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	150	Target Neighborhood Hits	103	Shared Neighborhood Hits	11
SwissProt Accessions	O75056, Q5T1Z6, Q5T1Z7, Q96CT3, Q96PR8	Gene names	SDC3, KIAA0468
Domain Architecture
Description	Syndecan-3 (SYND3).

T22D2_HUMAN
NC score	0.025495 (rank : 93)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	150	Target Neighborhood Hits	250	Shared Neighborhood Hits	25
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

HGS_HUMAN
NC score	0.025434 (rank : 94)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	150	Target Neighborhood Hits	517	Shared Neighborhood Hits	37
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

TARA_HUMAN
NC score	0.024266 (rank : 95)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	150	Target Neighborhood Hits	1626	Shared Neighborhood Hits	51
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

MYH9_HUMAN
NC score	0.024163 (rank : 96)	θ value	0.0563607 (rank : 44)
Query Neighborhood Hits	150	Target Neighborhood Hits	1762	Shared Neighborhood Hits	36
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
NC score	0.023462 (rank : 97)	θ value	0.0736092 (rank : 45)
Query Neighborhood Hits	150	Target Neighborhood Hits	1829	Shared Neighborhood Hits	33
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

DACH1_HUMAN
NC score	0.022404 (rank : 98)	θ value	1.06291 (rank : 72)
Query Neighborhood Hits	150	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UI36, O75523, O75687, Q5VYY3, Q5VYY4, Q96SG3, Q96SG4, Q9H524, Q9UMH4	Gene names	DACH1, DACH
Domain Architecture
Description	Dachshund homolog 1 (Dach1).

CD248_HUMAN
NC score	0.022363 (rank : 99)	θ value	0.21417 (rank : 51)
Query Neighborhood Hits	150	Target Neighborhood Hits	679	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

TIMD1_HUMAN
NC score	0.021785 (rank : 100)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	150	Target Neighborhood Hits	155	Shared Neighborhood Hits	12
SwissProt Accessions	Q96D42, O43656	Gene names	HAVCR1, TIM1, TIMD1
Domain Architecture	No domain graphic available
Description	Hepatitis A virus cellular receptor 1 precursor (HAVcr-1) (T cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T cell membrane protein 1) (TIM-1) (TIM).

TTLL5_MOUSE
NC score	0.021006 (rank : 101)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	150	Target Neighborhood Hits	150	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CHB8	Gene names	Ttll5, Kiaa0998
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5.

APOB_HUMAN
NC score	0.020144 (rank : 102)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	150	Target Neighborhood Hits	202	Shared Neighborhood Hits	9
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

TAF1C_MOUSE
NC score	0.018729 (rank : 103)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	150	Target Neighborhood Hits	54	Shared Neighborhood Hits	7
SwissProt Accessions	Q6PDZ2, P97359, Q3U3B6, Q8BN54	Gene names	Taf1c
Domain Architecture	No domain graphic available
Description	TATA box-binding protein-associated factor, RNA polymerase I, subunit C (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (TBP-associated factor RNA polymerase I 95 kDa) (TAFI95).

TAF3_HUMAN
NC score	0.018600 (rank : 104)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	150	Target Neighborhood Hits	568	Shared Neighborhood Hits	21
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

BRD4_HUMAN
NC score	0.018576 (rank : 105)	θ value	8.99809 (rank : 136)
Query Neighborhood Hits	150	Target Neighborhood Hits	851	Shared Neighborhood Hits	44
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

MYH10_HUMAN
NC score	0.018510 (rank : 106)	θ value	1.06291 (rank : 74)
Query Neighborhood Hits	150	Target Neighborhood Hits	1620	Shared Neighborhood Hits	28
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

RANB3_HUMAN
NC score	0.018471 (rank : 107)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	150	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H6Z4, O60405, O75759, O75760, Q9BT47, Q9UG74	Gene names	RANBP3
Domain Architecture	No domain graphic available
Description	Ran-binding protein 3 (RanBP3).

RN165_HUMAN
NC score	0.018460 (rank : 108)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	150	Target Neighborhood Hits	151	Shared Neighborhood Hits	3
SwissProt Accessions	Q6ZSG1	Gene names	RNF165
Domain Architecture	No domain graphic available
Description	RING finger protein 165.

MYH10_MOUSE
NC score	0.018268 (rank : 109)	θ value	1.38821 (rank : 81)
Query Neighborhood Hits	150	Target Neighborhood Hits	1612	Shared Neighborhood Hits	29
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

RFX1_HUMAN
NC score	0.018048 (rank : 110)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	150	Target Neighborhood Hits	256	Shared Neighborhood Hits	26
SwissProt Accessions	P22670	Gene names	RFX1
Domain Architecture
Description	MHC class II regulatory factor RFX1 (RFX) (Enhancer factor C) (EF-C).

MYH11_MOUSE
NC score	0.017678 (rank : 111)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	150	Target Neighborhood Hits	1777	Shared Neighborhood Hits	28
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_HUMAN
NC score	0.017515 (rank : 112)	θ value	2.36792 (rank : 92)
Query Neighborhood Hits	150	Target Neighborhood Hits	1806	Shared Neighborhood Hits	29
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CO039_MOUSE
NC score	0.017184 (rank : 113)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	150	Target Neighborhood Hits	445	Shared Neighborhood Hits	22
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

ATOH1_HUMAN
NC score	0.016670 (rank : 114)	θ value	1.81305 (rank : 84)
Query Neighborhood Hits	150	Target Neighborhood Hits	97	Shared Neighborhood Hits	5
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

AMOT_HUMAN
NC score	0.016391 (rank : 115)	θ value	4.03905 (rank : 101)
Query Neighborhood Hits	150	Target Neighborhood Hits	712	Shared Neighborhood Hits	23
SwissProt Accessions	Q4VCS5, Q504X5, Q9HD27, Q9UPT1	Gene names	AMOT, KIAA1071
Domain Architecture	No domain graphic available
Description	Angiomotin.

GAK2_HUMAN
NC score	0.015991 (rank : 116)	θ value	1.38821 (rank : 78)
Query Neighborhood Hits	150	Target Neighborhood Hits	406	Shared Neighborhood Hits	17
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

CIC_HUMAN
NC score	0.015117 (rank : 117)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	150	Target Neighborhood Hits	992	Shared Neighborhood Hits	50
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

GAK5_HUMAN
NC score	0.014640 (rank : 118)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	150	Target Neighborhood Hits	429	Shared Neighborhood Hits	19
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HCN1_MOUSE
NC score	0.014261 (rank : 119)	θ value	0.813845 (rank : 68)
Query Neighborhood Hits	150	Target Neighborhood Hits	172	Shared Neighborhood Hits	12
SwissProt Accessions	O88704, O54899, Q9D613	Gene names	Hcn1, Bcng1, Hac2
Domain Architecture
Description	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1) (Hyperpolarization-activated cation channel 2) (HAC-2).

K0240_MOUSE
NC score	0.014151 (rank : 120)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	150	Target Neighborhood Hits	211	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHH5	Gene names	Kiaa0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

GAK6_HUMAN
NC score	0.013899 (rank : 121)	θ value	6.88961 (rank : 119)
Query Neighborhood Hits	150	Target Neighborhood Hits	392	Shared Neighborhood Hits	16
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HAX1_MOUSE
NC score	0.013808 (rank : 122)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	150	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	O35387	Gene names	Hax1, Hs1bp1
Domain Architecture	No domain graphic available
Description	HS1-associating protein X-1 (HAX-1) (HS1-binding protein).

GAK4_HUMAN
NC score	0.013602 (rank : 123)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	150	Target Neighborhood Hits	415	Shared Neighborhood Hits	17
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK11_HUMAN
NC score	0.013597 (rank : 124)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	150	Target Neighborhood Hits	409	Shared Neighborhood Hits	17
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK12_HUMAN
NC score	0.013529 (rank : 125)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	150	Target Neighborhood Hits	374	Shared Neighborhood Hits	15
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

PO2F1_MOUSE
NC score	0.012660 (rank : 126)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	150	Target Neighborhood Hits	408	Shared Neighborhood Hits	12
SwissProt Accessions	P25425, Q61994, Q63891, Q6Y681, Q7TSD0, Q8BT04, Q8K570, Q99JH0, Q9WTZ4, Q9WTZ5, Q9WTZ6	Gene names	Pou2f1, Oct-1, Otf-1, Otf1
Domain Architecture
Description	POU domain, class 2, transcription factor 1 (Octamer-binding transcription factor 1) (Oct-1) (OTF-1) (NF-A1).

MUCEN_HUMAN
NC score	0.012657 (rank : 127)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	150	Target Neighborhood Hits	20	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ULC0, Q8NEY5, Q8WWE7, Q9NRM8	Gene names	EMCN, EMCN2. MUC14
Domain Architecture	No domain graphic available
Description	Endomucin precursor (Endomucin-2) (Gastric cancer antigen Ga34).

RUFY1_HUMAN
NC score	0.012508 (rank : 128)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	150	Target Neighborhood Hits	848	Shared Neighborhood Hits	17
SwissProt Accessions	Q96T51, Q59FF3, Q71S93, Q9H6I3	Gene names	RUFY1, RABIP4, ZFYVE12
Domain Architecture
Description	RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (Zinc finger FYVE domain-containing protein 12) (La-binding protein 1) (Rab4-interacting protein).

TEKT2_HUMAN
NC score	0.012407 (rank : 129)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	150	Target Neighborhood Hits	197	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UIF3, O60638	Gene names	TEKT2
Domain Architecture
Description	Tektin-2 (Testicular tektin) (Tektin-t) (Testicular tektin B1-like protein) (Tektin-B1) (TEKTB1).

TTLL4_HUMAN
NC score	0.012040 (rank : 130)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	150	Target Neighborhood Hits	79	Shared Neighborhood Hits	6
SwissProt Accessions	Q14679, Q8WW29	Gene names	TTLL4, KIAA0173
Domain Architecture
Description	Tubulin--tyrosine ligase-like protein 4.

RFFL_HUMAN
NC score	0.011680 (rank : 131)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	150	Target Neighborhood Hits	175	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

AMOL1_MOUSE
NC score	0.011306 (rank : 132)	θ value	8.99809 (rank : 135)
Query Neighborhood Hits	150	Target Neighborhood Hits	445	Shared Neighborhood Hits	17
SwissProt Accessions	Q9D4H4, Q571F1	Gene names	Amotl1
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 1.

GMEB2_HUMAN
NC score	0.011072 (rank : 133)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	150	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UKD1, Q5TDS0, Q9H431, Q9H4X7, Q9H4X8, Q9UF78, Q9ULF1	Gene names	GMEB2, KIAA1269
Domain Architecture
Description	Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (Parvovirus initiation factor p79) (PIF p79) (DNA-binding protein p79PIF).

BRCA1_MOUSE
NC score	0.010432 (rank : 134)	θ value	1.81305 (rank : 87)
Query Neighborhood Hits	150	Target Neighborhood Hits	436	Shared Neighborhood Hits	8
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

AKAP2_HUMAN
NC score	0.010278 (rank : 135)	θ value	8.99809 (rank : 134)
Query Neighborhood Hits	150	Target Neighborhood Hits	507	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y2D5, Q9UG26	Gene names	AKAP2, KIAA0920
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2).

IF35_HUMAN
NC score	0.009867 (rank : 136)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	150	Target Neighborhood Hits	130	Shared Neighborhood Hits	9
SwissProt Accessions	O00303, Q8N978	Gene names	EIF3S5
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 5 (eIF-3 epsilon) (eIF3 p47 subunit) (eIF3f).

KIF17_MOUSE
NC score	0.009807 (rank : 137)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	150	Target Neighborhood Hits	452	Shared Neighborhood Hits	18
SwissProt Accessions	Q99PW8	Gene names	Kif17
Domain Architecture
Description	Kinesin-like protein KIF17 (MmKIF17).

XKR5_MOUSE
NC score	0.009379 (rank : 138)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	150	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q5GH66	Gene names	Xkr5, Xrg5
Domain Architecture	No domain graphic available
Description	XK-related protein 5.

KIF17_HUMAN
NC score	0.008592 (rank : 139)	θ value	1.38821 (rank : 79)
Query Neighborhood Hits	150	Target Neighborhood Hits	365	Shared Neighborhood Hits	15
SwissProt Accessions	Q9P2E2, O95077, Q53YS6, Q5VWA9, Q6GSA8, Q8N411	Gene names	KIF17, KIAA1405, KIF3X
Domain Architecture
Description	Kinesin-like protein KIF17 (KIF3-related motor protein).

PI51A_HUMAN
NC score	0.008476 (rank : 140)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	150	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	Q99755, Q99754, Q99756	Gene names	PIP5K1A
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (EC 2.7.1.68) (Phosphatidylinositol-4-phosphate 5-kinase type I alpha) (PtdIns(4)P- 5-kinase alpha) (PIP5KIalpha) (68 kDa type I phosphatidylinositol-4- phosphate 5-kinase alpha).

CEP63_HUMAN
NC score	0.008023 (rank : 141)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	150	Target Neighborhood Hits	1005	Shared Neighborhood Hits	20
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

WNK1_MOUSE
NC score	0.008020 (rank : 142)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	150	Target Neighborhood Hits	1179	Shared Neighborhood Hits	36
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

GOGA5_MOUSE
NC score	0.007998 (rank : 143)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	150	Target Neighborhood Hits	1434	Shared Neighborhood Hits	23
SwissProt Accessions	Q9QYE6, O88317, Q3TGE7, Q3U6S5, Q3UUF9	Gene names	Golga5, Retii
Domain Architecture
Description	Golgin subfamily A member 5 (Golgin-84) (Sumiko protein) (Ret-II protein).

MCM6_MOUSE
NC score	0.007353 (rank : 144)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	150	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	P97311, Q80YQ7	Gene names	Mcm6, Mcmd6, Mis5
Domain Architecture
Description	DNA replication licensing factor MCM6 (Mis5 homolog).

WNK2_HUMAN
NC score	0.007259 (rank : 145)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	150	Target Neighborhood Hits	1407	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

CBL_MOUSE
NC score	0.007241 (rank : 146)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	150	Target Neighborhood Hits	426	Shared Neighborhood Hits	15
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

ELF1_MOUSE
NC score	0.006854 (rank : 147)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	150	Target Neighborhood Hits	139	Shared Neighborhood Hits	12
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

NMNA1_MOUSE
NC score	0.006534 (rank : 148)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	150	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPA7, Q6B504	Gene names	Nmnat1, D4Cole1e, Nmnat
Domain Architecture
Description	Nicotinamide mononucleotide adenylyltransferase 1 (EC 2.7.7.1) (NMN adenylyltransferase 1).

LIPA1_HUMAN
NC score	0.006245 (rank : 149)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	150	Target Neighborhood Hits	1294	Shared Neighborhood Hits	28
SwissProt Accessions	Q13136, Q13135, Q14567, Q8N4I2	Gene names	PPFIA1, LIP1
Domain Architecture
Description	Liprin-alpha-1 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1) (PTPRF-interacting protein alpha-1) (LAR-interacting protein 1) (LIP.1).

DCC_MOUSE
NC score	0.005681 (rank : 150)	θ value	1.06291 (rank : 73)
Query Neighborhood Hits	150	Target Neighborhood Hits	896	Shared Neighborhood Hits	22
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

ADA12_MOUSE
NC score	0.004716 (rank : 151)	θ value	1.81305 (rank : 83)
Query Neighborhood Hits	150	Target Neighborhood Hits	474	Shared Neighborhood Hits	14
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA19_HUMAN
NC score	0.003874 (rank : 152)	θ value	8.99809 (rank : 133)
Query Neighborhood Hits	150	Target Neighborhood Hits	381	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

IWS1_HUMAN
NC score	0.003278 (rank : 153)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	150	Target Neighborhood Hits	1241	Shared Neighborhood Hits	22
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

DLX5_MOUSE
NC score	0.003100 (rank : 154)	θ value	2.36792 (rank : 91)
Query Neighborhood Hits	150	Target Neighborhood Hits	434	Shared Neighborhood Hits	5
SwissProt Accessions	P70396, O54876, O54877, O54878, Q9JJ45	Gene names	Dlx5
Domain Architecture
Description	Homeobox protein DLX-5.

LTB1L_HUMAN
NC score	0.002560 (rank : 155)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	150	Target Neighborhood Hits	553	Shared Neighborhood Hits	13
SwissProt Accessions	Q14766	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1L precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

LTB1S_HUMAN
NC score	0.002506 (rank : 156)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	150	Target Neighborhood Hits	502	Shared Neighborhood Hits	11
SwissProt Accessions	P22064, Q8TD95	Gene names	LTBP1
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein, isoform 1S precursor (LTBP-1) (Transforming growth factor beta-1-binding protein 1) (TGF-beta1-BP-1).

POGK_MOUSE
NC score	0.001875 (rank : 157)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	150	Target Neighborhood Hits	257	Shared Neighborhood Hits	2
SwissProt Accessions	Q80TC5, Q8BPJ3, Q8C887	Gene names	Pogk, Kiaa1513
Domain Architecture
Description	Pogo transposable element with KRAB domain.

ULK1_HUMAN
NC score	-0.000603 (rank : 158)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	150	Target Neighborhood Hits	1121	Shared Neighborhood Hits	12
SwissProt Accessions	O75385	Gene names	ULK1
Domain Architecture
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1).

TITIN_HUMAN
NC score	-0.000892 (rank : 159)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	150	Target Neighborhood Hits	2923	Shared Neighborhood Hits	52
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

MK07_MOUSE
NC score	-0.001179 (rank : 160)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	150	Target Neighborhood Hits	1054	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVS8	Gene names	Mapk7, Erk5
Domain Architecture
Description	Mitogen-activated protein kinase 7 (EC 2.7.11.24) (Extracellular signal-regulated kinase 5) (ERK-5) (BMK1 kinase).

CDK8_HUMAN
NC score	-0.001377 (rank : 161)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	150	Target Neighborhood Hits	831	Shared Neighborhood Hits	8
SwissProt Accessions	P49336	Gene names	CDK8
Domain Architecture
Description	Cell division protein kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Protein kinase K35).

STK39_MOUSE
NC score	-0.002592 (rank : 162)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	150	Target Neighborhood Hits	915	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).