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Network neighborhood for query Sequence : USF2_HUMAN

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USF2_HUMAN
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

USF2_MOUSE
θ value	1.41267e-170 (rank : 1)	NC score	0.992906 (rank : 2)
Query Neighborhood Hits	155	Target Neighborhood Hits	173	Shared Neighborhood Hits	143
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
θ value	1.6163e-166 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	155	Target Neighborhood Hits	155	Shared Neighborhood Hits	155
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF1_MOUSE
θ value	1.95861e-79 (rank : 3)	NC score	0.949116 (rank : 4)
Query Neighborhood Hits	155	Target Neighborhood Hits	71	Shared Neighborhood Hits	60
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
θ value	2.55803e-79 (rank : 4)	NC score	0.949506 (rank : 3)
Query Neighborhood Hits	155	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MITF_HUMAN
θ value	1.38499e-08 (rank : 5)	NC score	0.517998 (rank : 8)
Query Neighborhood Hits	155	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_HUMAN
θ value	1.80886e-08 (rank : 6)	NC score	0.503386 (rank : 11)
Query Neighborhood Hits	155	Target Neighborhood Hits	111	Shared Neighborhood Hits	54
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	1.80886e-08 (rank : 7)	NC score	0.503856 (rank : 10)
Query Neighborhood Hits	155	Target Neighborhood Hits	119	Shared Neighborhood Hits	54
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

MITF_MOUSE
θ value	4.0297e-08 (rank : 8)	NC score	0.513430 (rank : 9)
Query Neighborhood Hits	155	Target Neighborhood Hits	115	Shared Neighborhood Hits	57
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
θ value	1.17247e-07 (rank : 9)	NC score	0.527883 (rank : 7)
Query Neighborhood Hits	155	Target Neighborhood Hits	190	Shared Neighborhood Hits	69
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MAX_HUMAN
θ value	3.41135e-07 (rank : 10)	NC score	0.565091 (rank : 5)
Query Neighborhood Hits	155	Target Neighborhood Hits	125	Shared Neighborhood Hits	60
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	3.41135e-07 (rank : 11)	NC score	0.552235 (rank : 6)
Query Neighborhood Hits	155	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

SRBP2_HUMAN
θ value	9.92553e-07 (rank : 12)	NC score	0.426778 (rank : 12)
Query Neighborhood Hits	155	Target Neighborhood Hits	133	Shared Neighborhood Hits	52
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

SRBP1_HUMAN
θ value	8.40245e-06 (rank : 13)	NC score	0.392121 (rank : 15)
Query Neighborhood Hits	155	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
θ value	2.44474e-05 (rank : 14)	NC score	0.380085 (rank : 16)
Query Neighborhood Hits	155	Target Neighborhood Hits	384	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

BMAL1_HUMAN
θ value	5.44631e-05 (rank : 15)	NC score	0.261539 (rank : 40)
Query Neighborhood Hits	155	Target Neighborhood Hits	115	Shared Neighborhood Hits	50
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	5.44631e-05 (rank : 16)	NC score	0.262672 (rank : 39)
Query Neighborhood Hits	155	Target Neighborhood Hits	121	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

MLX_HUMAN
θ value	0.000121331 (rank : 17)	NC score	0.409565 (rank : 14)
Query Neighborhood Hits	155	Target Neighborhood Hits	95	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	0.000121331 (rank : 18)	NC score	0.421414 (rank : 13)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	47
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

ARNT_HUMAN
θ value	0.000461057 (rank : 19)	NC score	0.271355 (rank : 36)
Query Neighborhood Hits	155	Target Neighborhood Hits	109	Shared Neighborhood Hits	48
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	0.000461057 (rank : 20)	NC score	0.265429 (rank : 37)
Query Neighborhood Hits	155	Target Neighborhood Hits	213	Shared Neighborhood Hits	47
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_HUMAN
θ value	0.000602161 (rank : 21)	NC score	0.258175 (rank : 42)
Query Neighborhood Hits	155	Target Neighborhood Hits	109	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	0.000602161 (rank : 22)	NC score	0.258678 (rank : 41)
Query Neighborhood Hits	155	Target Neighborhood Hits	115	Shared Neighborhood Hits	45
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

MYCN_HUMAN
θ value	0.000602161 (rank : 23)	NC score	0.361386 (rank : 18)
Query Neighborhood Hits	155	Target Neighborhood Hits	127	Shared Neighborhood Hits	48
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MXI1_MOUSE
θ value	0.00102713 (rank : 24)	NC score	0.347672 (rank : 21)
Query Neighborhood Hits	155	Target Neighborhood Hits	109	Shared Neighborhood Hits	44
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD4_HUMAN
θ value	0.00228821 (rank : 25)	NC score	0.353202 (rank : 19)
Query Neighborhood Hits	155	Target Neighborhood Hits	94	Shared Neighborhood Hits	49
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MXI1_HUMAN
θ value	0.00228821 (rank : 26)	NC score	0.341876 (rank : 23)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCN_MOUSE
θ value	0.00228821 (rank : 27)	NC score	0.352257 (rank : 20)
Query Neighborhood Hits	155	Target Neighborhood Hits	125	Shared Neighborhood Hits	51
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCS_MOUSE
θ value	0.00298849 (rank : 28)	NC score	0.332027 (rank : 24)
Query Neighborhood Hits	155	Target Neighborhood Hits	83	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

HEY2_HUMAN
θ value	0.00390308 (rank : 29)	NC score	0.300093 (rank : 28)
Query Neighborhood Hits	155	Target Neighborhood Hits	77	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

MYC_HUMAN
θ value	0.00390308 (rank : 30)	NC score	0.347627 (rank : 22)
Query Neighborhood Hits	155	Target Neighborhood Hits	146	Shared Neighborhood Hits	52
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_MOUSE
θ value	0.00390308 (rank : 31)	NC score	0.364873 (rank : 17)
Query Neighborhood Hits	155	Target Neighborhood Hits	125	Shared Neighborhood Hits	48
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MNT_HUMAN
θ value	0.00509761 (rank : 32)	NC score	0.265301 (rank : 38)
Query Neighborhood Hits	155	Target Neighborhood Hits	496	Shared Neighborhood Hits	56
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	0.00509761 (rank : 33)	NC score	0.275182 (rank : 34)
Query Neighborhood Hits	155	Target Neighborhood Hits	432	Shared Neighborhood Hits	53
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HEY2_MOUSE
θ value	0.00869519 (rank : 34)	NC score	0.298020 (rank : 29)
Query Neighborhood Hits	155	Target Neighborhood Hits	80	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MAD3_MOUSE
θ value	0.00869519 (rank : 35)	NC score	0.305783 (rank : 27)
Query Neighborhood Hits	155	Target Neighborhood Hits	94	Shared Neighborhood Hits	42
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MAD3_HUMAN
θ value	0.0113563 (rank : 36)	NC score	0.313247 (rank : 26)
Query Neighborhood Hits	155	Target Neighborhood Hits	92	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

BHLH8_HUMAN
θ value	0.0148317 (rank : 37)	NC score	0.157255 (rank : 56)
Query Neighborhood Hits	155	Target Neighborhood Hits	123	Shared Neighborhood Hits	31
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
θ value	0.0148317 (rank : 38)	NC score	0.154232 (rank : 57)
Query Neighborhood Hits	155	Target Neighborhood Hits	107	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

TFAP4_HUMAN
θ value	0.0148317 (rank : 39)	NC score	0.315859 (rank : 25)
Query Neighborhood Hits	155	Target Neighborhood Hits	289	Shared Neighborhood Hits	64
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

MAD4_MOUSE
θ value	0.0193708 (rank : 40)	NC score	0.275535 (rank : 33)
Query Neighborhood Hits	155	Target Neighborhood Hits	65	Shared Neighborhood Hits	33
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

HEY1_HUMAN
θ value	0.0330416 (rank : 41)	NC score	0.272305 (rank : 35)
Query Neighborhood Hits	155	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	0.0330416 (rank : 42)	NC score	0.276970 (rank : 32)
Query Neighborhood Hits	155	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

WBS14_HUMAN
θ value	0.0330416 (rank : 43)	NC score	0.182713 (rank : 52)
Query Neighborhood Hits	155	Target Neighborhood Hits	273	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

HAND2_HUMAN
θ value	0.0431538 (rank : 44)	NC score	0.125650 (rank : 62)
Query Neighborhood Hits	155	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
θ value	0.0431538 (rank : 45)	NC score	0.125650 (rank : 63)
Query Neighborhood Hits	155	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

WBS14_MOUSE
θ value	0.0431538 (rank : 46)	NC score	0.183980 (rank : 49)
Query Neighborhood Hits	155	Target Neighborhood Hits	171	Shared Neighborhood Hits	22
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

SMC3_HUMAN
θ value	0.0736092 (rank : 47)	NC score	0.072290 (rank : 74)
Query Neighborhood Hits	155	Target Neighborhood Hits	1186	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	0.0736092 (rank : 48)	NC score	0.072446 (rank : 73)
Query Neighborhood Hits	155	Target Neighborhood Hits	1187	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

MYCL1_HUMAN
θ value	0.125558 (rank : 49)	NC score	0.297245 (rank : 30)
Query Neighborhood Hits	155	Target Neighborhood Hits	146	Shared Neighborhood Hits	53
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL2_HUMAN
θ value	0.125558 (rank : 50)	NC score	0.225708 (rank : 46)
Query Neighborhood Hits	155	Target Neighborhood Hits	63	Shared Neighborhood Hits	35
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

FOSL2_HUMAN
θ value	0.163984 (rank : 51)	NC score	0.071818 (rank : 76)
Query Neighborhood Hits	155	Target Neighborhood Hits	158	Shared Neighborhood Hits	18
SwissProt Accessions	P15408	Gene names	FOSL2, FRA2
Domain Architecture	No domain graphic available
Description	Fos-related antigen 2.

MCA1_HUMAN
θ value	0.163984 (rank : 52)	NC score	0.084697 (rank : 68)
Query Neighborhood Hits	155	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	Q12904, Q6FG28, Q96CQ9	Gene names	SCYE1, EMAP2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

UACA_MOUSE
θ value	0.163984 (rank : 53)	NC score	0.047674 (rank : 143)
Query Neighborhood Hits	155	Target Neighborhood Hits	1620	Shared Neighborhood Hits	68
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

KTN1_HUMAN
θ value	0.21417 (rank : 54)	NC score	0.065014 (rank : 83)
Query Neighborhood Hits	155	Target Neighborhood Hits	1197	Shared Neighborhood Hits	66
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

TCFL5_HUMAN
θ value	0.21417 (rank : 55)	NC score	0.232648 (rank : 45)
Query Neighborhood Hits	155	Target Neighborhood Hits	43	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

HCFC1_HUMAN
θ value	0.279714 (rank : 56)	NC score	0.053211 (rank : 114)
Query Neighborhood Hits	155	Target Neighborhood Hits	331	Shared Neighborhood Hits	8
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

HCFC1_MOUSE
θ value	0.279714 (rank : 57)	NC score	0.053121 (rank : 116)
Query Neighborhood Hits	155	Target Neighborhood Hits	348	Shared Neighborhood Hits	6
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

KTN1_MOUSE
θ value	0.279714 (rank : 58)	NC score	0.060845 (rank : 98)
Query Neighborhood Hits	155	Target Neighborhood Hits	1324	Shared Neighborhood Hits	65
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

MYCL1_MOUSE
θ value	0.279714 (rank : 59)	NC score	0.293780 (rank : 31)
Query Neighborhood Hits	155	Target Neighborhood Hits	123	Shared Neighborhood Hits	51
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

SWP70_HUMAN
θ value	0.365318 (rank : 60)	NC score	0.061206 (rank : 95)
Query Neighborhood Hits	155	Target Neighborhood Hits	973	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

HES4_HUMAN
θ value	0.47712 (rank : 61)	NC score	0.180311 (rank : 53)
Query Neighborhood Hits	155	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

MAD1_HUMAN
θ value	0.47712 (rank : 62)	NC score	0.236783 (rank : 44)
Query Neighborhood Hits	155	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SWP70_MOUSE
θ value	0.47712 (rank : 63)	NC score	0.059132 (rank : 100)
Query Neighborhood Hits	155	Target Neighborhood Hits	1097	Shared Neighborhood Hits	58
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENPE_HUMAN
θ value	0.62314 (rank : 64)	NC score	0.045069 (rank : 150)
Query Neighborhood Hits	155	Target Neighborhood Hits	2060	Shared Neighborhood Hits	78
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

GAS8_MOUSE
θ value	0.62314 (rank : 65)	NC score	0.064846 (rank : 84)
Query Neighborhood Hits	155	Target Neighborhood Hits	622	Shared Neighborhood Hits	54
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

MAD1_MOUSE
θ value	0.62314 (rank : 66)	NC score	0.257720 (rank : 43)
Query Neighborhood Hits	155	Target Neighborhood Hits	75	Shared Neighborhood Hits	44
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

ASPP2_HUMAN
θ value	0.813845 (rank : 67)	NC score	0.038093 (rank : 164)
Query Neighborhood Hits	155	Target Neighborhood Hits	1156	Shared Neighborhood Hits	56
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

FOSL2_MOUSE
θ value	0.813845 (rank : 68)	NC score	0.063119 (rank : 86)
Query Neighborhood Hits	155	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	P47930	Gene names	Fosl2, Fra-2, Fra2
Domain Architecture	No domain graphic available
Description	Fos-related antigen 2.

HES1_HUMAN
θ value	0.813845 (rank : 69)	NC score	0.183010 (rank : 51)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	31
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	0.813845 (rank : 70)	NC score	0.183361 (rank : 50)
Query Neighborhood Hits	155	Target Neighborhood Hits	78	Shared Neighborhood Hits	31
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

NPAS2_HUMAN
θ value	0.813845 (rank : 71)	NC score	0.135239 (rank : 58)
Query Neighborhood Hits	155	Target Neighborhood Hits	150	Shared Neighborhood Hits	31
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	0.813845 (rank : 72)	NC score	0.134909 (rank : 59)
Query Neighborhood Hits	155	Target Neighborhood Hits	132	Shared Neighborhood Hits	30
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NUMA1_HUMAN
θ value	0.813845 (rank : 73)	NC score	0.053103 (rank : 117)
Query Neighborhood Hits	155	Target Neighborhood Hits	1523	Shared Neighborhood Hits	69
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

PKHA4_MOUSE
θ value	0.813845 (rank : 74)	NC score	0.042255 (rank : 157)
Query Neighborhood Hits	155	Target Neighborhood Hits	202	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

BHLH3_HUMAN
θ value	1.06291 (rank : 75)	NC score	0.197948 (rank : 47)
Query Neighborhood Hits	155	Target Neighborhood Hits	106	Shared Neighborhood Hits	44
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

GOGA3_HUMAN
θ value	1.06291 (rank : 76)	NC score	0.056288 (rank : 106)
Query Neighborhood Hits	155	Target Neighborhood Hits	1317	Shared Neighborhood Hits	66
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

GOGA3_MOUSE
θ value	1.06291 (rank : 77)	NC score	0.055087 (rank : 110)
Query Neighborhood Hits	155	Target Neighborhood Hits	1437	Shared Neighborhood Hits	65
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

MCA1_MOUSE
θ value	1.06291 (rank : 78)	NC score	0.072184 (rank : 75)
Query Neighborhood Hits	155	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	P31230, Q60659	Gene names	Scye1, Emap2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

TRIPB_HUMAN
θ value	1.06291 (rank : 79)	NC score	0.060531 (rank : 99)
Query Neighborhood Hits	155	Target Neighborhood Hits	1587	Shared Neighborhood Hits	77
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

AKAP9_HUMAN
θ value	1.38821 (rank : 80)	NC score	0.051562 (rank : 130)
Query Neighborhood Hits	155	Target Neighborhood Hits	1710	Shared Neighborhood Hits	71
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

BHLH2_HUMAN
θ value	1.38821 (rank : 81)	NC score	0.169556 (rank : 54)
Query Neighborhood Hits	155	Target Neighborhood Hits	80	Shared Neighborhood Hits	46
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH3_MOUSE
θ value	1.38821 (rank : 82)	NC score	0.191900 (rank : 48)
Query Neighborhood Hits	155	Target Neighborhood Hits	70	Shared Neighborhood Hits	43
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BRE1A_MOUSE
θ value	1.38821 (rank : 83)	NC score	0.050429 (rank : 137)
Query Neighborhood Hits	155	Target Neighborhood Hits	1025	Shared Neighborhood Hits	59
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

FA50B_HUMAN
θ value	1.38821 (rank : 84)	NC score	0.035925 (rank : 167)
Query Neighborhood Hits	155	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y247	Gene names	FAM50B, X5L
Domain Architecture
Description	Protein FAM50B (XAP-5-like protein).

GCC2_HUMAN
θ value	1.38821 (rank : 85)	NC score	0.051931 (rank : 125)
Query Neighborhood Hits	155	Target Neighborhood Hits	1558	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
θ value	1.38821 (rank : 86)	NC score	0.052104 (rank : 122)
Query Neighborhood Hits	155	Target Neighborhood Hits	1559	Shared Neighborhood Hits	73
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

ATF3_HUMAN
θ value	1.81305 (rank : 87)	NC score	0.061522 (rank : 94)
Query Neighborhood Hits	155	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	P18847	Gene names	ATF3
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-3 (Activating transcription factor 3).

ATF3_MOUSE
θ value	1.81305 (rank : 88)	NC score	0.062116 (rank : 90)
Query Neighborhood Hits	155	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q60765	Gene names	Atf3
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-3 (Activating transcription factor 3) (Transcription factor LRG-21).

BHLH2_MOUSE
θ value	1.81305 (rank : 89)	NC score	0.168124 (rank : 55)
Query Neighborhood Hits	155	Target Neighborhood Hits	70	Shared Neighborhood Hits	42
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

CAR14_HUMAN
θ value	1.81305 (rank : 90)	NC score	0.047742 (rank : 142)
Query Neighborhood Hits	155	Target Neighborhood Hits	449	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

CYTSA_HUMAN
θ value	1.81305 (rank : 91)	NC score	0.054744 (rank : 112)
Query Neighborhood Hits	155	Target Neighborhood Hits	1138	Shared Neighborhood Hits	70
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

ACTN3_HUMAN
θ value	2.36792 (rank : 92)	NC score	0.016511 (rank : 189)
Query Neighborhood Hits	155	Target Neighborhood Hits	272	Shared Neighborhood Hits	27
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

MORC3_HUMAN
θ value	2.36792 (rank : 93)	NC score	0.046120 (rank : 148)
Query Neighborhood Hits	155	Target Neighborhood Hits	489	Shared Neighborhood Hits	52
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

ADIPO_MOUSE
θ value	3.0926 (rank : 94)	NC score	0.009745 (rank : 196)
Query Neighborhood Hits	155	Target Neighborhood Hits	182	Shared Neighborhood Hits	3
SwissProt Accessions	Q60994, Q62400, Q9DC68	Gene names	Adipoq, Acdc, Acrp30, Apm1
Domain Architecture
Description	Adiponectin precursor (Adipocyte, C1q and collagen domain-containing protein) (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte-specific protein AdipoQ).

ATOH1_HUMAN
θ value	3.0926 (rank : 95)	NC score	0.058298 (rank : 101)
Query Neighborhood Hits	155	Target Neighborhood Hits	97	Shared Neighborhood Hits	19
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

ATOH1_MOUSE
θ value	3.0926 (rank : 96)	NC score	0.057483 (rank : 104)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

CEBPE_HUMAN
θ value	3.0926 (rank : 97)	NC score	0.028892 (rank : 177)
Query Neighborhood Hits	155	Target Neighborhood Hits	236	Shared Neighborhood Hits	16
SwissProt Accessions	Q15744, Q15745, Q8IYI2, Q99803	Gene names	CEBPE
Domain Architecture
Description	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon).

COVA1_HUMAN
θ value	3.0926 (rank : 98)	NC score	0.050436 (rank : 136)
Query Neighborhood Hits	155	Target Neighborhood Hits	416	Shared Neighborhood Hits	38
SwissProt Accessions	Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82	Gene names	COVA1
Domain Architecture
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

HAND1_HUMAN
θ value	3.0926 (rank : 99)	NC score	0.092265 (rank : 66)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	28
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

PSIP1_HUMAN
θ value	3.0926 (rank : 100)	NC score	0.021957 (rank : 182)
Query Neighborhood Hits	155	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

ZHX2_MOUSE
θ value	3.0926 (rank : 101)	NC score	0.016993 (rank : 188)
Query Neighborhood Hits	155	Target Neighborhood Hits	435	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C0C0	Gene names	Zhx2, Afr1, Raf
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

MD1L1_HUMAN
θ value	4.03905 (rank : 102)	NC score	0.048571 (rank : 140)
Query Neighborhood Hits	155	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

MYH3_HUMAN
θ value	4.03905 (rank : 103)	NC score	0.036326 (rank : 166)
Query Neighborhood Hits	155	Target Neighborhood Hits	1660	Shared Neighborhood Hits	73
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

WWTR1_MOUSE
θ value	4.03905 (rank : 104)	NC score	0.028958 (rank : 176)
Query Neighborhood Hits	155	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

XBP1_MOUSE
θ value	4.03905 (rank : 105)	NC score	0.051505 (rank : 131)
Query Neighborhood Hits	155	Target Neighborhood Hits	99	Shared Neighborhood Hits	16
SwissProt Accessions	O35426, Q8VHM0, Q922G5, Q9ESS3	Gene names	Xbp1, Treb5
Domain Architecture	No domain graphic available
Description	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5 homolog).

ABCCB_HUMAN
θ value	5.27518 (rank : 106)	NC score	0.005941 (rank : 198)
Query Neighborhood Hits	155	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	Q96J66, Q8TDJ0, Q96JA6, Q9BX80	Gene names	ABCC11, MRP8
Domain Architecture	No domain graphic available
Description	ATP-binding cassette transporter sub-family C member 11 (Multidrug resistance-associated protein 8).

BPAEA_MOUSE
θ value	5.27518 (rank : 107)	NC score	0.042725 (rank : 155)
Query Neighborhood Hits	155	Target Neighborhood Hits	1480	Shared Neighborhood Hits	75
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

BRE1A_HUMAN
θ value	5.27518 (rank : 108)	NC score	0.045041 (rank : 151)
Query Neighborhood Hits	155	Target Neighborhood Hits	1071	Shared Neighborhood Hits	59
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

HAND1_MOUSE
θ value	5.27518 (rank : 109)	NC score	0.088288 (rank : 67)
Query Neighborhood Hits	155	Target Neighborhood Hits	107	Shared Neighborhood Hits	30
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

K0240_MOUSE
θ value	5.27518 (rank : 110)	NC score	0.016183 (rank : 191)
Query Neighborhood Hits	155	Target Neighborhood Hits	211	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CHH5	Gene names	Kiaa0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

LAMA5_MOUSE
θ value	5.27518 (rank : 111)	NC score	0.008799 (rank : 197)
Query Neighborhood Hits	155	Target Neighborhood Hits	828	Shared Neighborhood Hits	36
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LMNA_MOUSE
θ value	5.27518 (rank : 112)	NC score	0.030204 (rank : 173)
Query Neighborhood Hits	155	Target Neighborhood Hits	661	Shared Neighborhood Hits	53
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

MY18A_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.038132 (rank : 163)
Query Neighborhood Hits	155	Target Neighborhood Hits	1929	Shared Neighborhood Hits	75
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

NAF1_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.047471 (rank : 144)
Query Neighborhood Hits	155	Target Neighborhood Hits	937	Shared Neighborhood Hits	57
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NAF1_MOUSE
θ value	5.27518 (rank : 115)	NC score	0.050403 (rank : 138)
Query Neighborhood Hits	155	Target Neighborhood Hits	852	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

OFD1_HUMAN
θ value	5.27518 (rank : 116)	NC score	0.046364 (rank : 147)
Query Neighborhood Hits	155	Target Neighborhood Hits	753	Shared Neighborhood Hits	51
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

RBCC1_HUMAN
θ value	5.27518 (rank : 117)	NC score	0.045382 (rank : 149)
Query Neighborhood Hits	155	Target Neighborhood Hits	1023	Shared Neighborhood Hits	60
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

ROCK1_HUMAN
θ value	5.27518 (rank : 118)	NC score	0.016184 (rank : 190)
Query Neighborhood Hits	155	Target Neighborhood Hits	2000	Shared Neighborhood Hits	66
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

WWTR1_HUMAN
θ value	5.27518 (rank : 119)	NC score	0.025554 (rank : 178)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

ZO3_MOUSE
θ value	5.27518 (rank : 120)	NC score	0.010403 (rank : 194)
Query Neighborhood Hits	155	Target Neighborhood Hits	224	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ANGP4_HUMAN
θ value	6.88961 (rank : 121)	NC score	0.010363 (rank : 195)
Query Neighborhood Hits	155	Target Neighborhood Hits	187	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y264, Q9H4Z4	Gene names	ANGPT4, ANG3, ANG4
Domain Architecture
Description	Angiopoietin-4 precursor (ANG-4) (ANG-3).

ANR18_HUMAN
θ value	6.88961 (rank : 122)	NC score	0.031576 (rank : 171)
Query Neighborhood Hits	155	Target Neighborhood Hits	1106	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

COVA1_MOUSE
θ value	6.88961 (rank : 123)	NC score	0.044370 (rank : 153)
Query Neighborhood Hits	155	Target Neighborhood Hits	335	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R0Z2, Q8BY59, Q8R372	Gene names	Cova1
Domain Architecture	No domain graphic available
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

CP250_HUMAN
θ value	6.88961 (rank : 124)	NC score	0.041811 (rank : 158)
Query Neighborhood Hits	155	Target Neighborhood Hits	1805	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

CYTSA_MOUSE
θ value	6.88961 (rank : 125)	NC score	0.051570 (rank : 129)
Query Neighborhood Hits	155	Target Neighborhood Hits	1104	Shared Neighborhood Hits	69
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

GOGA6_HUMAN
θ value	6.88961 (rank : 126)	NC score	0.043064 (rank : 154)
Query Neighborhood Hits	155	Target Neighborhood Hits	1007	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

HOOK2_HUMAN
θ value	6.88961 (rank : 127)	NC score	0.039755 (rank : 161)
Query Neighborhood Hits	155	Target Neighborhood Hits	714	Shared Neighborhood Hits	53
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

LZTS1_MOUSE
θ value	6.88961 (rank : 128)	NC score	0.038811 (rank : 162)
Query Neighborhood Hits	155	Target Neighborhood Hits	540	Shared Neighborhood Hits	51
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

MYH1_HUMAN
θ value	6.88961 (rank : 129)	NC score	0.034220 (rank : 169)
Query Neighborhood Hits	155	Target Neighborhood Hits	1478	Shared Neighborhood Hits	68
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH9_HUMAN
θ value	6.88961 (rank : 130)	NC score	0.036987 (rank : 165)
Query Neighborhood Hits	155	Target Neighborhood Hits	1762	Shared Neighborhood Hits	76
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NIN_MOUSE
θ value	6.88961 (rank : 131)	NC score	0.047465 (rank : 145)
Query Neighborhood Hits	155	Target Neighborhood Hits	1376	Shared Neighborhood Hits	71
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

PEPL_MOUSE
θ value	6.88961 (rank : 132)	NC score	0.044622 (rank : 152)
Query Neighborhood Hits	155	Target Neighborhood Hits	1105	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

PKHA4_HUMAN
θ value	6.88961 (rank : 133)	NC score	0.030369 (rank : 172)
Query Neighborhood Hits	155	Target Neighborhood Hits	283	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

SH3G1_HUMAN
θ value	6.88961 (rank : 134)	NC score	0.021815 (rank : 183)
Query Neighborhood Hits	155	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	6.88961 (rank : 135)	NC score	0.022373 (rank : 181)
Query Neighborhood Hits	155	Target Neighborhood Hits	291	Shared Neighborhood Hits	18
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	6.88961 (rank : 136)	NC score	0.020542 (rank : 184)
Query Neighborhood Hits	155	Target Neighborhood Hits	324	Shared Neighborhood Hits	20
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	6.88961 (rank : 137)	NC score	0.020369 (rank : 185)
Query Neighborhood Hits	155	Target Neighborhood Hits	319	Shared Neighborhood Hits	19
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

U2AFL_HUMAN
θ value	6.88961 (rank : 138)	NC score	0.029101 (rank : 174)
Query Neighborhood Hits	155	Target Neighborhood Hits	503	Shared Neighborhood Hits	45
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

APC_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.025026 (rank : 179)
Query Neighborhood Hits	155	Target Neighborhood Hits	603	Shared Neighborhood Hits	34
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

APC_MOUSE
θ value	8.99809 (rank : 140)	NC score	0.022501 (rank : 180)
Query Neighborhood Hits	155	Target Neighborhood Hits	441	Shared Neighborhood Hits	30
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

CENPF_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.046774 (rank : 146)
Query Neighborhood Hits	155	Target Neighborhood Hits	1932	Shared Neighborhood Hits	80
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CKAP2_HUMAN
θ value	8.99809 (rank : 142)	NC score	0.011779 (rank : 193)
Query Neighborhood Hits	155	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WWK9, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4	Gene names	CKAP2, LB1, TMAP
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2 (Tumor-associated microtubule- associated protein) (CTCL tumor antigen se20-10).

GAS8_HUMAN
θ value	8.99809 (rank : 143)	NC score	0.048026 (rank : 141)
Query Neighborhood Hits	155	Target Neighborhood Hits	819	Shared Neighborhood Hits	56
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

GCC2_MOUSE
θ value	8.99809 (rank : 144)	NC score	0.049064 (rank : 139)
Query Neighborhood Hits	155	Target Neighborhood Hits	1619	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

GOGB1_HUMAN
θ value	8.99809 (rank : 145)	NC score	0.042477 (rank : 156)
Query Neighborhood Hits	155	Target Neighborhood Hits	2297	Shared Neighborhood Hits	75
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

GRAP1_HUMAN
θ value	8.99809 (rank : 146)	NC score	0.041646 (rank : 159)
Query Neighborhood Hits	155	Target Neighborhood Hits	944	Shared Neighborhood Hits	57
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

GRAP1_MOUSE
θ value	8.99809 (rank : 147)	NC score	0.041112 (rank : 160)
Query Neighborhood Hits	155	Target Neighborhood Hits	1234	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

K2C4_MOUSE
θ value	8.99809 (rank : 148)	NC score	0.019484 (rank : 186)
Query Neighborhood Hits	155	Target Neighborhood Hits	521	Shared Neighborhood Hits	46
SwissProt Accessions	P07744, Q6P3F5	Gene names	Krt4, Krt2-4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Cytoskeletal 57 kDa keratin).

LMNA_HUMAN
θ value	8.99809 (rank : 149)	NC score	0.029081 (rank : 175)
Query Neighborhood Hits	155	Target Neighborhood Hits	653	Shared Neighborhood Hits	53
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

MYH1_MOUSE
θ value	8.99809 (rank : 150)	NC score	0.033696 (rank : 170)
Query Neighborhood Hits	155	Target Neighborhood Hits	1461	Shared Neighborhood Hits	67
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH8_MOUSE
θ value	8.99809 (rank : 151)	NC score	0.035789 (rank : 168)
Query Neighborhood Hits	155	Target Neighborhood Hits	1600	Shared Neighborhood Hits	71
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

PTPRT_HUMAN
θ value	8.99809 (rank : 152)	NC score	0.002938 (rank : 199)
Query Neighborhood Hits	155	Target Neighborhood Hits	217	Shared Neighborhood Hits	4
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
θ value	8.99809 (rank : 153)	NC score	0.002935 (rank : 200)
Query Neighborhood Hits	155	Target Neighborhood Hits	219	Shared Neighborhood Hits	4
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).

SAFB1_HUMAN
θ value	8.99809 (rank : 154)	NC score	0.018616 (rank : 187)
Query Neighborhood Hits	155	Target Neighborhood Hits	493	Shared Neighborhood Hits	29
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

ZHX2_HUMAN
θ value	8.99809 (rank : 155)	NC score	0.012403 (rank : 192)
Query Neighborhood Hits	155	Target Neighborhood Hits	347	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6X8	Gene names	ZHX2, AFR1, KIAA0854, RAF
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

AHR_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.057900 (rank : 103)
Query Neighborhood Hits	155	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

AHR_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.052435 (rank : 118)
Query Neighborhood Hits	155	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

ASCL1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.053173 (rank : 115)
Query Neighborhood Hits	155	Target Neighborhood Hits	94	Shared Neighborhood Hits	19
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

ASCL1_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.050530 (rank : 134)
Query Neighborhood Hits	155	Target Neighborhood Hits	97	Shared Neighborhood Hits	19
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

ASCL2_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.056124 (rank : 108)
Query Neighborhood Hits	155	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

CLOCK_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.130622 (rank : 61)
Query Neighborhood Hits	155	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.132895 (rank : 60)
Query Neighborhood Hits	155	Target Neighborhood Hits	148	Shared Neighborhood Hits	36
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

EPAS1_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.068232 (rank : 79)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.067952 (rank : 80)
Query Neighborhood Hits	155	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

FIGLA_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.074427 (rank : 72)
Query Neighborhood Hits	155	Target Neighborhood Hits	108	Shared Neighborhood Hits	25
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

FIGLA_MOUSE
θ value	θ > 10 (rank : 166)	NC score	0.071205 (rank : 77)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	23
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

HES2_HUMAN
θ value	θ > 10 (rank : 167)	NC score	0.070692 (rank : 78)
Query Neighborhood Hits	155	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_MOUSE
θ value	θ > 10 (rank : 168)	NC score	0.077818 (rank : 70)
Query Neighborhood Hits	155	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.062808 (rank : 89)
Query Neighborhood Hits	155	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES5_MOUSE
θ value	θ > 10 (rank : 170)	NC score	0.117727 (rank : 64)
Query Neighborhood Hits	155	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES6_HUMAN
θ value	θ > 10 (rank : 171)	NC score	0.076359 (rank : 71)
Query Neighborhood Hits	155	Target Neighborhood Hits	49	Shared Neighborhood Hits	17
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
θ value	θ > 10 (rank : 172)	NC score	0.077901 (rank : 69)
Query Neighborhood Hits	155	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.064187 (rank : 85)
Query Neighborhood Hits	155	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.062926 (rank : 88)
Query Neighborhood Hits	155	Target Neighborhood Hits	72	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HIF1A_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.065699 (rank : 81)
Query Neighborhood Hits	155	Target Neighborhood Hits	118	Shared Neighborhood Hits	11
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.065608 (rank : 82)
Query Neighborhood Hits	155	Target Neighborhood Hits	90	Shared Neighborhood Hits	11
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

MYCB_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.110954 (rank : 65)
Query Neighborhood Hits	155	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

NCOA1_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.060957 (rank : 97)
Query Neighborhood Hits	155	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.061002 (rank : 96)
Query Neighborhood Hits	155	Target Neighborhood Hits	196	Shared Neighborhood Hits	25
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA3_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.050448 (rank : 135)
Query Neighborhood Hits	155	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

NGN3_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.053866 (rank : 113)
Query Neighborhood Hits	155	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

NPAS1_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.051585 (rank : 128)
Query Neighborhood Hits	155	Target Neighborhood Hits	77	Shared Neighborhood Hits	10
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

NPAS1_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.051055 (rank : 133)
Query Neighborhood Hits	155	Target Neighborhood Hits	63	Shared Neighborhood Hits	8
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

NPAS3_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.056283 (rank : 107)
Query Neighborhood Hits	155	Target Neighborhood Hits	81	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

NPAS3_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.058097 (rank : 102)
Query Neighborhood Hits	155	Target Neighborhood Hits	103	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

PER2_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.051200 (rank : 132)
Query Neighborhood Hits	155	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

PER2_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.055093 (rank : 109)
Query Neighborhood Hits	155	Target Neighborhood Hits	325	Shared Neighborhood Hits	15
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.052070 (rank : 123)
Query Neighborhood Hits	155	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PTF1A_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.052019 (rank : 124)
Query Neighborhood Hits	155	Target Neighborhood Hits	95	Shared Neighborhood Hits	22
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

PTF1A_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.052199 (rank : 121)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

SIM1_HUMAN
θ value	θ > 10 (rank : 191)	NC score	0.061870 (rank : 91)
Query Neighborhood Hits	155	Target Neighborhood Hits	62	Shared Neighborhood Hits	12
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
θ value	θ > 10 (rank : 192)	NC score	0.061810 (rank : 92)
Query Neighborhood Hits	155	Target Neighborhood Hits	69	Shared Neighborhood Hits	12
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.063002 (rank : 87)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

SIM2_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.061674 (rank : 93)
Query Neighborhood Hits	155	Target Neighborhood Hits	75	Shared Neighborhood Hits	12
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

TAL1_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.056514 (rank : 105)
Query Neighborhood Hits	155	Target Neighborhood Hits	112	Shared Neighborhood Hits	26
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

TAL1_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.054892 (rank : 111)
Query Neighborhood Hits	155	Target Neighborhood Hits	110	Shared Neighborhood Hits	26
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

TWST1_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.052327 (rank : 119)
Query Neighborhood Hits	155	Target Neighborhood Hits	93	Shared Neighborhood Hits	20
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.052255 (rank : 120)
Query Neighborhood Hits	155	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

TWST2_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.051862 (rank : 126)
Query Neighborhood Hits	155	Target Neighborhood Hits	107	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_MOUSE
θ value	θ > 10 (rank : 200)	NC score	0.051767 (rank : 127)
Query Neighborhood Hits	155	Target Neighborhood Hits	107	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

Hits sorted by NC score

USF2_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.6163e-166 (rank : 2)
Query Neighborhood Hits	155	Target Neighborhood Hits	155	Shared Neighborhood Hits	155
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.992906 (rank : 2)	θ value	1.41267e-170 (rank : 1)
Query Neighborhood Hits	155	Target Neighborhood Hits	173	Shared Neighborhood Hits	143
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF1_HUMAN
NC score	0.949506 (rank : 3)	θ value	2.55803e-79 (rank : 4)
Query Neighborhood Hits	155	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.949116 (rank : 4)	θ value	1.95861e-79 (rank : 3)
Query Neighborhood Hits	155	Target Neighborhood Hits	71	Shared Neighborhood Hits	60
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MAX_HUMAN
NC score	0.565091 (rank : 5)	θ value	3.41135e-07 (rank : 10)
Query Neighborhood Hits	155	Target Neighborhood Hits	125	Shared Neighborhood Hits	60
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
NC score	0.552235 (rank : 6)	θ value	3.41135e-07 (rank : 11)
Query Neighborhood Hits	155	Target Neighborhood Hits	139	Shared Neighborhood Hits	65
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

TFE3_HUMAN
NC score	0.527883 (rank : 7)	θ value	1.17247e-07 (rank : 9)
Query Neighborhood Hits	155	Target Neighborhood Hits	190	Shared Neighborhood Hits	69
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_HUMAN
NC score	0.517998 (rank : 8)	θ value	1.38499e-08 (rank : 5)
Query Neighborhood Hits	155	Target Neighborhood Hits	113	Shared Neighborhood Hits	56
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.513430 (rank : 9)	θ value	4.0297e-08 (rank : 8)
Query Neighborhood Hits	155	Target Neighborhood Hits	115	Shared Neighborhood Hits	57
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFEB_MOUSE
NC score	0.503856 (rank : 10)	θ value	1.80886e-08 (rank : 7)
Query Neighborhood Hits	155	Target Neighborhood Hits	119	Shared Neighborhood Hits	54
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.503386 (rank : 11)	θ value	1.80886e-08 (rank : 6)
Query Neighborhood Hits	155	Target Neighborhood Hits	111	Shared Neighborhood Hits	54
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

SRBP2_HUMAN
NC score	0.426778 (rank : 12)	θ value	9.92553e-07 (rank : 12)
Query Neighborhood Hits	155	Target Neighborhood Hits	133	Shared Neighborhood Hits	52
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

MLX_MOUSE
NC score	0.421414 (rank : 13)	θ value	0.000121331 (rank : 18)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	47
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.409565 (rank : 14)	θ value	0.000121331 (rank : 17)
Query Neighborhood Hits	155	Target Neighborhood Hits	95	Shared Neighborhood Hits	44
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

SRBP1_HUMAN
NC score	0.392121 (rank : 15)	θ value	8.40245e-06 (rank : 13)
Query Neighborhood Hits	155	Target Neighborhood Hits	225	Shared Neighborhood Hits	51
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
NC score	0.380085 (rank : 16)	θ value	2.44474e-05 (rank : 14)
Query Neighborhood Hits	155	Target Neighborhood Hits	384	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYC_MOUSE
NC score	0.364873 (rank : 17)	θ value	0.00390308 (rank : 31)
Query Neighborhood Hits	155	Target Neighborhood Hits	125	Shared Neighborhood Hits	48
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCN_HUMAN
NC score	0.361386 (rank : 18)	θ value	0.000602161 (rank : 23)
Query Neighborhood Hits	155	Target Neighborhood Hits	127	Shared Neighborhood Hits	48
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MAD4_HUMAN
NC score	0.353202 (rank : 19)	θ value	0.00228821 (rank : 25)
Query Neighborhood Hits	155	Target Neighborhood Hits	94	Shared Neighborhood Hits	49
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYCN_MOUSE
NC score	0.352257 (rank : 20)	θ value	0.00228821 (rank : 27)
Query Neighborhood Hits	155	Target Neighborhood Hits	125	Shared Neighborhood Hits	51
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MXI1_MOUSE
NC score	0.347672 (rank : 21)	θ value	0.00102713 (rank : 24)
Query Neighborhood Hits	155	Target Neighborhood Hits	109	Shared Neighborhood Hits	44
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYC_HUMAN
NC score	0.347627 (rank : 22)	θ value	0.00390308 (rank : 30)
Query Neighborhood Hits	155	Target Neighborhood Hits	146	Shared Neighborhood Hits	52
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MXI1_HUMAN
NC score	0.341876 (rank : 23)	θ value	0.00228821 (rank : 26)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	43
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCS_MOUSE
NC score	0.332027 (rank : 24)	θ value	0.00298849 (rank : 28)
Query Neighborhood Hits	155	Target Neighborhood Hits	83	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

TFAP4_HUMAN
NC score	0.315859 (rank : 25)	θ value	0.0148317 (rank : 39)
Query Neighborhood Hits	155	Target Neighborhood Hits	289	Shared Neighborhood Hits	64
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

MAD3_HUMAN
NC score	0.313247 (rank : 26)	θ value	0.0113563 (rank : 36)
Query Neighborhood Hits	155	Target Neighborhood Hits	92	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAD3_MOUSE
NC score	0.305783 (rank : 27)	θ value	0.00869519 (rank : 35)
Query Neighborhood Hits	155	Target Neighborhood Hits	94	Shared Neighborhood Hits	42
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

HEY2_HUMAN
NC score	0.300093 (rank : 28)	θ value	0.00390308 (rank : 29)
Query Neighborhood Hits	155	Target Neighborhood Hits	77	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.298020 (rank : 29)	θ value	0.00869519 (rank : 34)
Query Neighborhood Hits	155	Target Neighborhood Hits	80	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MYCL1_HUMAN
NC score	0.297245 (rank : 30)	θ value	0.125558 (rank : 49)
Query Neighborhood Hits	155	Target Neighborhood Hits	146	Shared Neighborhood Hits	53
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
NC score	0.293780 (rank : 31)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	155	Target Neighborhood Hits	123	Shared Neighborhood Hits	51
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

HEY1_MOUSE
NC score	0.276970 (rank : 32)	θ value	0.0330416 (rank : 42)
Query Neighborhood Hits	155	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

MAD4_MOUSE
NC score	0.275535 (rank : 33)	θ value	0.0193708 (rank : 40)
Query Neighborhood Hits	155	Target Neighborhood Hits	65	Shared Neighborhood Hits	33
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MNT_MOUSE
NC score	0.275182 (rank : 34)	θ value	0.00509761 (rank : 33)
Query Neighborhood Hits	155	Target Neighborhood Hits	432	Shared Neighborhood Hits	53
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HEY1_HUMAN
NC score	0.272305 (rank : 35)	θ value	0.0330416 (rank : 41)
Query Neighborhood Hits	155	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

ARNT_HUMAN
NC score	0.271355 (rank : 36)	θ value	0.000461057 (rank : 19)
Query Neighborhood Hits	155	Target Neighborhood Hits	109	Shared Neighborhood Hits	48
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.265429 (rank : 37)	θ value	0.000461057 (rank : 20)
Query Neighborhood Hits	155	Target Neighborhood Hits	213	Shared Neighborhood Hits	47
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

MNT_HUMAN
NC score	0.265301 (rank : 38)	θ value	0.00509761 (rank : 32)
Query Neighborhood Hits	155	Target Neighborhood Hits	496	Shared Neighborhood Hits	56
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

BMAL1_MOUSE
NC score	0.262672 (rank : 39)	θ value	5.44631e-05 (rank : 16)
Query Neighborhood Hits	155	Target Neighborhood Hits	121	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.261539 (rank : 40)	θ value	5.44631e-05 (rank : 15)
Query Neighborhood Hits	155	Target Neighborhood Hits	115	Shared Neighborhood Hits	50
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

ARNT2_MOUSE
NC score	0.258678 (rank : 41)	θ value	0.000602161 (rank : 22)
Query Neighborhood Hits	155	Target Neighborhood Hits	115	Shared Neighborhood Hits	45
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.258175 (rank : 42)	θ value	0.000602161 (rank : 21)
Query Neighborhood Hits	155	Target Neighborhood Hits	109	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

MAD1_MOUSE
NC score	0.257720 (rank : 43)	θ value	0.62314 (rank : 66)
Query Neighborhood Hits	155	Target Neighborhood Hits	75	Shared Neighborhood Hits	44
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD1_HUMAN
NC score	0.236783 (rank : 44)	θ value	0.47712 (rank : 62)
Query Neighborhood Hits	155	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

TCFL5_HUMAN
NC score	0.232648 (rank : 45)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	155	Target Neighborhood Hits	43	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MYCL2_HUMAN
NC score	0.225708 (rank : 46)	θ value	0.125558 (rank : 50)
Query Neighborhood Hits	155	Target Neighborhood Hits	63	Shared Neighborhood Hits	35
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

BHLH3_HUMAN
NC score	0.197948 (rank : 47)	θ value	1.06291 (rank : 75)
Query Neighborhood Hits	155	Target Neighborhood Hits	106	Shared Neighborhood Hits	44
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.191900 (rank : 48)	θ value	1.38821 (rank : 82)
Query Neighborhood Hits	155	Target Neighborhood Hits	70	Shared Neighborhood Hits	43
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

WBS14_MOUSE
NC score	0.183980 (rank : 49)	θ value	0.0431538 (rank : 46)
Query Neighborhood Hits	155	Target Neighborhood Hits	171	Shared Neighborhood Hits	22
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

HES1_MOUSE
NC score	0.183361 (rank : 50)	θ value	0.813845 (rank : 70)
Query Neighborhood Hits	155	Target Neighborhood Hits	78	Shared Neighborhood Hits	31
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES1_HUMAN
NC score	0.183010 (rank : 51)	θ value	0.813845 (rank : 69)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	31
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

WBS14_HUMAN
NC score	0.182713 (rank : 52)	θ value	0.0330416 (rank : 43)
Query Neighborhood Hits	155	Target Neighborhood Hits	273	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

HES4_HUMAN
NC score	0.180311 (rank : 53)	θ value	0.47712 (rank : 61)
Query Neighborhood Hits	155	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

BHLH2_HUMAN
NC score	0.169556 (rank : 54)	θ value	1.38821 (rank : 81)
Query Neighborhood Hits	155	Target Neighborhood Hits	80	Shared Neighborhood Hits	46
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.168124 (rank : 55)	θ value	1.81305 (rank : 89)
Query Neighborhood Hits	155	Target Neighborhood Hits	70	Shared Neighborhood Hits	42
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH8_HUMAN
NC score	0.157255 (rank : 56)	θ value	0.0148317 (rank : 37)
Query Neighborhood Hits	155	Target Neighborhood Hits	123	Shared Neighborhood Hits	31
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
NC score	0.154232 (rank : 57)	θ value	0.0148317 (rank : 38)
Query Neighborhood Hits	155	Target Neighborhood Hits	107	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

NPAS2_HUMAN
NC score	0.135239 (rank : 58)	θ value	0.813845 (rank : 71)
Query Neighborhood Hits	155	Target Neighborhood Hits	150	Shared Neighborhood Hits	31
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.134909 (rank : 59)	θ value	0.813845 (rank : 72)
Query Neighborhood Hits	155	Target Neighborhood Hits	132	Shared Neighborhood Hits	30
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

CLOCK_MOUSE
NC score	0.132895 (rank : 60)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	155	Target Neighborhood Hits	148	Shared Neighborhood Hits	36
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

CLOCK_HUMAN
NC score	0.130622 (rank : 61)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	155	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

HAND2_HUMAN
NC score	0.125650 (rank : 62)	θ value	0.0431538 (rank : 44)
Query Neighborhood Hits	155	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
NC score	0.125650 (rank : 63)	θ value	0.0431538 (rank : 45)
Query Neighborhood Hits	155	Target Neighborhood Hits	99	Shared Neighborhood Hits	24
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

HES5_MOUSE
NC score	0.117727 (rank : 64)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	155	Target Neighborhood Hits	38	Shared Neighborhood Hits	19
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

MYCB_MOUSE
NC score	0.110954 (rank : 65)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	155	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

HAND1_HUMAN
NC score	0.092265 (rank : 66)	θ value	3.0926 (rank : 99)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	28
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HAND1_MOUSE
NC score	0.088288 (rank : 67)	θ value	5.27518 (rank : 109)
Query Neighborhood Hits	155	Target Neighborhood Hits	107	Shared Neighborhood Hits	30
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

MCA1_HUMAN
NC score	0.084697 (rank : 68)	θ value	0.163984 (rank : 52)
Query Neighborhood Hits	155	Target Neighborhood Hits	86	Shared Neighborhood Hits	17
SwissProt Accessions	Q12904, Q6FG28, Q96CQ9	Gene names	SCYE1, EMAP2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

HES6_MOUSE
NC score	0.077901 (rank : 69)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	155	Target Neighborhood Hits	49	Shared Neighborhood Hits	18
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES2_MOUSE
NC score	0.077818 (rank : 70)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	155	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES6_HUMAN
NC score	0.076359 (rank : 71)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	155	Target Neighborhood Hits	49	Shared Neighborhood Hits	17
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

FIGLA_HUMAN
NC score	0.074427 (rank : 72)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	155	Target Neighborhood Hits	108	Shared Neighborhood Hits	25
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

SMC3_MOUSE
NC score	0.072446 (rank : 73)	θ value	0.0736092 (rank : 48)
Query Neighborhood Hits	155	Target Neighborhood Hits	1187	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.072290 (rank : 74)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	155	Target Neighborhood Hits	1186	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

MCA1_MOUSE
NC score	0.072184 (rank : 75)	θ value	1.06291 (rank : 78)
Query Neighborhood Hits	155	Target Neighborhood Hits	96	Shared Neighborhood Hits	19
SwissProt Accessions	P31230, Q60659	Gene names	Scye1, Emap2
Domain Architecture
Description	Multisynthetase complex auxiliary component p43 [Contains: Endothelial monocyte-activating polypeptide 2 (EMAP-II) (Small inducible cytokine subfamily E member 1)].

FOSL2_HUMAN
NC score	0.071818 (rank : 76)	θ value	0.163984 (rank : 51)
Query Neighborhood Hits	155	Target Neighborhood Hits	158	Shared Neighborhood Hits	18
SwissProt Accessions	P15408	Gene names	FOSL2, FRA2
Domain Architecture	No domain graphic available
Description	Fos-related antigen 2.

FIGLA_MOUSE
NC score	0.071205 (rank : 77)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	23
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

HES2_HUMAN
NC score	0.070692 (rank : 78)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	155	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

EPAS1_HUMAN
NC score	0.068232 (rank : 79)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	8
SwissProt Accessions	Q99814, Q86VA2, Q99630	Gene names	EPAS1, HIF2A
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Member of PAS protein 2) (MOP2) (Hypoxia-inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (HLF).

EPAS1_MOUSE
NC score	0.067952 (rank : 80)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	155	Target Neighborhood Hits	94	Shared Neighborhood Hits	8
SwissProt Accessions	P97481, O08787, O55046	Gene names	Epas1, Hif2a
Domain Architecture
Description	Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia- inducible factor 2 alpha) (HIF-2 alpha) (HIF2 alpha) (HIF-1 alpha-like factor) (MHLF) (HIF-related factor) (HRF).

HIF1A_HUMAN
NC score	0.065699 (rank : 81)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	155	Target Neighborhood Hits	118	Shared Neighborhood Hits	11
SwissProt Accessions	Q16665, Q96PT9, Q9UPB1	Gene names	HIF1A
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein) (Member of PAS protein 1) (MOP1).

HIF1A_MOUSE
NC score	0.065608 (rank : 82)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	155	Target Neighborhood Hits	90	Shared Neighborhood Hits	11
SwissProt Accessions	Q61221, O08741, O08993, Q61664, Q61665, Q8C681, Q8CC19, Q8CCB6, Q8R385, Q9CYA8	Gene names	Hif1a
Domain Architecture
Description	Hypoxia-inducible factor 1 alpha (HIF-1 alpha) (HIF1 alpha) (ARNT- interacting protein).

KTN1_HUMAN
NC score	0.065014 (rank : 83)	θ value	0.21417 (rank : 54)
Query Neighborhood Hits	155	Target Neighborhood Hits	1197	Shared Neighborhood Hits	66
SwissProt Accessions	Q86UP2, Q13999, Q14707, Q15387, Q86W57	Gene names	KTN1, CG1, KIAA0004
Domain Architecture	No domain graphic available
Description	Kinectin (Kinesin receptor) (CG-1 antigen).

GAS8_MOUSE
NC score	0.064846 (rank : 84)	θ value	0.62314 (rank : 65)
Query Neighborhood Hits	155	Target Neighborhood Hits	622	Shared Neighborhood Hits	54
SwissProt Accessions	Q60779, Q99L71	Gene names	Gas8, Gas11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

HES7_HUMAN
NC score	0.064187 (rank : 85)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	155	Target Neighborhood Hits	72	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

FOSL2_MOUSE
NC score	0.063119 (rank : 86)	θ value	0.813845 (rank : 68)
Query Neighborhood Hits	155	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	P47930	Gene names	Fosl2, Fra-2, Fra2
Domain Architecture	No domain graphic available
Description	Fos-related antigen 2.

SIM2_HUMAN
NC score	0.063002 (rank : 87)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q14190, O60766, Q15470, Q15471, Q15472, Q15473, Q16532	Gene names	SIM2
Domain Architecture
Description	Single-minded homolog 2.

HES7_MOUSE
NC score	0.062926 (rank : 88)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	155	Target Neighborhood Hits	72	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES3_MOUSE
NC score	0.062808 (rank : 89)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	155	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

ATF3_MOUSE
NC score	0.062116 (rank : 90)	θ value	1.81305 (rank : 88)
Query Neighborhood Hits	155	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q60765	Gene names	Atf3
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-3 (Activating transcription factor 3) (Transcription factor LRG-21).

SIM1_HUMAN
NC score	0.061870 (rank : 91)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	155	Target Neighborhood Hits	62	Shared Neighborhood Hits	12
SwissProt Accessions	P81133, Q5TDP7	Gene names	SIM1
Domain Architecture
Description	Single-minded homolog 1.

SIM1_MOUSE
NC score	0.061810 (rank : 92)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	155	Target Neighborhood Hits	69	Shared Neighborhood Hits	12
SwissProt Accessions	Q61045, O70284, P70183	Gene names	Sim1
Domain Architecture
Description	Single-minded homolog 1 (mSIM1).

SIM2_MOUSE
NC score	0.061674 (rank : 93)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	155	Target Neighborhood Hits	75	Shared Neighborhood Hits	12
SwissProt Accessions	Q61079, O35391, Q61046, Q61904	Gene names	Sim2
Domain Architecture
Description	Single-minded homolog 2 (SIM transcription factor) (mSIM).

ATF3_HUMAN
NC score	0.061522 (rank : 94)	θ value	1.81305 (rank : 87)
Query Neighborhood Hits	155	Target Neighborhood Hits	120	Shared Neighborhood Hits	16
SwissProt Accessions	P18847	Gene names	ATF3
Domain Architecture
Description	Cyclic AMP-dependent transcription factor ATF-3 (Activating transcription factor 3).

SWP70_HUMAN
NC score	0.061206 (rank : 95)	θ value	0.365318 (rank : 60)
Query Neighborhood Hits	155	Target Neighborhood Hits	973	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

NCOA1_MOUSE
NC score	0.061002 (rank : 96)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	155	Target Neighborhood Hits	196	Shared Neighborhood Hits	25
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.060957 (rank : 97)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	155	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

KTN1_MOUSE
NC score	0.060845 (rank : 98)	θ value	0.279714 (rank : 58)
Query Neighborhood Hits	155	Target Neighborhood Hits	1324	Shared Neighborhood Hits	65
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

TRIPB_HUMAN
NC score	0.060531 (rank : 99)	θ value	1.06291 (rank : 79)
Query Neighborhood Hits	155	Target Neighborhood Hits	1587	Shared Neighborhood Hits	77
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

SWP70_MOUSE
NC score	0.059132 (rank : 100)	θ value	0.47712 (rank : 63)
Query Neighborhood Hits	155	Target Neighborhood Hits	1097	Shared Neighborhood Hits	58
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ATOH1_HUMAN
NC score	0.058298 (rank : 101)	θ value	3.0926 (rank : 95)
Query Neighborhood Hits	155	Target Neighborhood Hits	97	Shared Neighborhood Hits	19
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

NPAS3_MOUSE
NC score	0.058097 (rank : 102)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	155	Target Neighborhood Hits	103	Shared Neighborhood Hits	12
SwissProt Accessions	Q9QZQ0, Q9EQP4	Gene names	Npas3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

AHR_HUMAN
NC score	0.057900 (rank : 103)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	155	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

ATOH1_MOUSE
NC score	0.057483 (rank : 104)	θ value	3.0926 (rank : 96)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	18
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

TAL1_HUMAN
NC score	0.056514 (rank : 105)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	155	Target Neighborhood Hits	112	Shared Neighborhood Hits	26
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

GOGA3_HUMAN
NC score	0.056288 (rank : 106)	θ value	1.06291 (rank : 76)
Query Neighborhood Hits	155	Target Neighborhood Hits	1317	Shared Neighborhood Hits	66
SwissProt Accessions	Q08378, O43241, Q6P9C7, Q86XW3, Q8TDA9, Q8WZA3	Gene names	GOLGA3
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Golgi complex-associated protein of 170 kDa) (GCP170).

NPAS3_HUMAN
NC score	0.056283 (rank : 107)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	155	Target Neighborhood Hits	81	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IXF0, Q86US6, Q86US7, Q8IXF2, Q9BY81, Q9H323, Q9Y4L8	Gene names	NPAS3
Domain Architecture
Description	Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Member of PAS protein 6) (MOP6).

ASCL2_MOUSE
NC score	0.056124 (rank : 108)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	155	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

PER2_MOUSE
NC score	0.055093 (rank : 109)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	155	Target Neighborhood Hits	325	Shared Neighborhood Hits	15
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

GOGA3_MOUSE
NC score	0.055087 (rank : 110)	θ value	1.06291 (rank : 77)
Query Neighborhood Hits	155	Target Neighborhood Hits	1437	Shared Neighborhood Hits	65
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

TAL1_MOUSE
NC score	0.054892 (rank : 111)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	155	Target Neighborhood Hits	110	Shared Neighborhood Hits	26
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

CYTSA_HUMAN
NC score	0.054744 (rank : 112)	θ value	1.81305 (rank : 91)
Query Neighborhood Hits	155	Target Neighborhood Hits	1138	Shared Neighborhood Hits	70
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

NGN3_MOUSE
NC score	0.053866 (rank : 113)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	155	Target Neighborhood Hits	90	Shared Neighborhood Hits	20
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

HCFC1_HUMAN
NC score	0.053211 (rank : 114)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	155	Target Neighborhood Hits	331	Shared Neighborhood Hits	8
SwissProt Accessions	P51610, Q6P4G5	Gene names	HCFC1, HCF1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) (VP16 accessory protein) (VCAF) (CFF) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C- terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

ASCL1_HUMAN
NC score	0.053173 (rank : 115)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	155	Target Neighborhood Hits	94	Shared Neighborhood Hits	19
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

HCFC1_MOUSE
NC score	0.053121 (rank : 116)	θ value	0.279714 (rank : 57)
Query Neighborhood Hits	155	Target Neighborhood Hits	348	Shared Neighborhood Hits	6
SwissProt Accessions	Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2	Gene names	Hcfc1
Domain Architecture	No domain graphic available
Description	Host cell factor (HCF) (HCF-1) (C1 factor) [Contains: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N- terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6].

NUMA1_HUMAN
NC score	0.053103 (rank : 117)	θ value	0.813845 (rank : 73)
Query Neighborhood Hits	155	Target Neighborhood Hits	1523	Shared Neighborhood Hits	69
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

AHR_MOUSE
NC score	0.052435 (rank : 118)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	155	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	P30561, Q8QZX6, Q8R4S3, Q99P79, Q9QVY1	Gene names	Ahr
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

TWST1_HUMAN
NC score	0.052327 (rank : 119)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	155	Target Neighborhood Hits	93	Shared Neighborhood Hits	20
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
NC score	0.052255 (rank : 120)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	155	Target Neighborhood Hits	101	Shared Neighborhood Hits	20
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

PTF1A_MOUSE
NC score	0.052199 (rank : 121)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	155	Target Neighborhood Hits	100	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

RBP24_HUMAN
NC score	0.052104 (rank : 122)	θ value	1.38821 (rank : 86)
Query Neighborhood Hits	155	Target Neighborhood Hits	1559	Shared Neighborhood Hits	73
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

PER3_MOUSE
NC score	0.052070 (rank : 123)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	155	Target Neighborhood Hits	85	Shared Neighborhood Hits	10
SwissProt Accessions	O70361	Gene names	Per3
Domain Architecture
Description	Period circadian protein 3 (mPER3).

PTF1A_HUMAN
NC score	0.052019 (rank : 124)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	155	Target Neighborhood Hits	95	Shared Neighborhood Hits	22
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

GCC2_HUMAN
NC score	0.051931 (rank : 125)	θ value	1.38821 (rank : 85)
Query Neighborhood Hits	155	Target Neighborhood Hits	1558	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

TWST2_HUMAN
NC score	0.051862 (rank : 126)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	155	Target Neighborhood Hits	107	Shared Neighborhood Hits	20
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_MOUSE
NC score	0.051767 (rank : 127)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	155	Target Neighborhood Hits	107	Shared Neighborhood Hits	20
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

NPAS1_HUMAN
NC score	0.051585 (rank : 128)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	155	Target Neighborhood Hits	77	Shared Neighborhood Hits	10
SwissProt Accessions	Q99742, Q99632, Q9BY83	Gene names	NPAS1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Member of PAS protein 5) (MOP5).

CYTSA_MOUSE
NC score	0.051570 (rank : 129)	θ value	6.88961 (rank : 125)
Query Neighborhood Hits	155	Target Neighborhood Hits	1104	Shared Neighborhood Hits	69
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

AKAP9_HUMAN
NC score	0.051562 (rank : 130)	θ value	1.38821 (rank : 80)
Query Neighborhood Hits	155	Target Neighborhood Hits	1710	Shared Neighborhood Hits	71
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

XBP1_MOUSE
NC score	0.051505 (rank : 131)	θ value	4.03905 (rank : 105)
Query Neighborhood Hits	155	Target Neighborhood Hits	99	Shared Neighborhood Hits	16
SwissProt Accessions	O35426, Q8VHM0, Q922G5, Q9ESS3	Gene names	Xbp1, Treb5
Domain Architecture	No domain graphic available
Description	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5 homolog).

PER2_HUMAN
NC score	0.051200 (rank : 132)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	155	Target Neighborhood Hits	170	Shared Neighborhood Hits	9
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

NPAS1_MOUSE
NC score	0.051055 (rank : 133)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	155	Target Neighborhood Hits	63	Shared Neighborhood Hits	8
SwissProt Accessions	P97459	Gene names	Npas1
Domain Architecture
Description	Neuronal PAS domain-containing protein 1 (Neuronal PAS1).

ASCL1_MOUSE
NC score	0.050530 (rank : 134)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	155	Target Neighborhood Hits	97	Shared Neighborhood Hits	19
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

NCOA3_HUMAN
NC score	0.050448 (rank : 135)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	155	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

COVA1_HUMAN
NC score	0.050436 (rank : 136)	θ value	3.0926 (rank : 98)
Query Neighborhood Hits	155	Target Neighborhood Hits	416	Shared Neighborhood Hits	38
SwissProt Accessions	Q16206, Q5VTJ1, Q5VTJ2, Q8WUX0, Q9NTP6, Q9UH82	Gene names	COVA1
Domain Architecture
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

BRE1A_MOUSE
NC score	0.050429 (rank : 137)	θ value	1.38821 (rank : 83)
Query Neighborhood Hits	155	Target Neighborhood Hits	1025	Shared Neighborhood Hits	59
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

NAF1_MOUSE
NC score	0.050403 (rank : 138)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	155	Target Neighborhood Hits	852	Shared Neighborhood Hits	55
SwissProt Accessions	Q9WUU8, Q922A9, Q922F7, Q9EPP8, Q9R0X3	Gene names	Tnip1, Abin, Naf1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (A20- binding inhibitor of NF-kappa-B activation) (ABIN) (Virion-associated nuclear shuttling protein) (VAN) (mVAN).

GCC2_MOUSE
NC score	0.049064 (rank : 139)	θ value	8.99809 (rank : 144)
Query Neighborhood Hits	155	Target Neighborhood Hits	1619	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

MD1L1_HUMAN
NC score	0.048571 (rank : 140)	θ value	4.03905 (rank : 102)
Query Neighborhood Hits	155	Target Neighborhood Hits	893	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

GAS8_HUMAN
NC score	0.048026 (rank : 141)	θ value	8.99809 (rank : 143)
Query Neighborhood Hits	155	Target Neighborhood Hits	819	Shared Neighborhood Hits	56
SwissProt Accessions	O95995	Gene names	GAS8, GAS11
Domain Architecture	No domain graphic available
Description	Growth-arrest-specific protein 8 (Growth arrest-specific 11).

CAR14_HUMAN
NC score	0.047742 (rank : 142)	θ value	1.81305 (rank : 90)
Query Neighborhood Hits	155	Target Neighborhood Hits	449	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BXL6, Q9BVB5	Gene names	CARD14, CARMA2
Domain Architecture
Description	Caspase recruitment domain-containing protein 14 (CARD-containing MAGUK protein 2) (Carma 2).

UACA_MOUSE
NC score	0.047674 (rank : 143)	θ value	0.163984 (rank : 53)
Query Neighborhood Hits	155	Target Neighborhood Hits	1620	Shared Neighborhood Hits	68
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

NAF1_HUMAN
NC score	0.047471 (rank : 144)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	155	Target Neighborhood Hits	937	Shared Neighborhood Hits	57
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NIN_MOUSE
NC score	0.047465 (rank : 145)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	155	Target Neighborhood Hits	1376	Shared Neighborhood Hits	71
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

CENPF_HUMAN
NC score	0.046774 (rank : 146)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	155	Target Neighborhood Hits	1932	Shared Neighborhood Hits	80
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

OFD1_HUMAN
NC score	0.046364 (rank : 147)	θ value	5.27518 (rank : 116)
Query Neighborhood Hits	155	Target Neighborhood Hits	753	Shared Neighborhood Hits	51
SwissProt Accessions	O75665, O75666	Gene names	OFD1, CXorf5
Domain Architecture	No domain graphic available
Description	Oral-facial-digital syndrome 1 protein (Protein 71-7A).

MORC3_HUMAN
NC score	0.046120 (rank : 148)	θ value	2.36792 (rank : 93)
Query Neighborhood Hits	155	Target Neighborhood Hits	489	Shared Neighborhood Hits	52
SwissProt Accessions	Q14149, Q9UEZ2	Gene names	MORC3, KIAA0136, ZCWCC3
Domain Architecture	No domain graphic available
Description	MORC family CW-type zinc finger protein 3 (Zinc finger CW-type coiled- coil domain protein 3).

RBCC1_HUMAN
NC score	0.045382 (rank : 149)	θ value	5.27518 (rank : 117)
Query Neighborhood Hits	155	Target Neighborhood Hits	1023	Shared Neighborhood Hits	60
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

CENPE_HUMAN
NC score	0.045069 (rank : 150)	θ value	0.62314 (rank : 64)
Query Neighborhood Hits	155	Target Neighborhood Hits	2060	Shared Neighborhood Hits	78
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

BRE1A_HUMAN
NC score	0.045041 (rank : 151)	θ value	5.27518 (rank : 108)
Query Neighborhood Hits	155	Target Neighborhood Hits	1071	Shared Neighborhood Hits	59
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

PEPL_MOUSE
NC score	0.044622 (rank : 152)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	155	Target Neighborhood Hits	1105	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R269, O70231, Q9CUT1, Q9JLZ7	Gene names	Ppl
Domain Architecture
Description	Periplakin.

COVA1_MOUSE
NC score	0.044370 (rank : 153)	θ value	6.88961 (rank : 123)
Query Neighborhood Hits	155	Target Neighborhood Hits	335	Shared Neighborhood Hits	31
SwissProt Accessions	Q8R0Z2, Q8BY59, Q8R372	Gene names	Cova1
Domain Architecture	No domain graphic available
Description	Tumor-associated hydroquinone oxidase (tNOX) (Cytosolic ovarian carcinoma antigen 1) (APK1 antigen) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)].

GOGA6_HUMAN
NC score	0.043064 (rank : 154)	θ value	6.88961 (rank : 126)
Query Neighborhood Hits	155	Target Neighborhood Hits	1007	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NYA3, Q9NYA7	Gene names	GOLGA6, GLP
Domain Architecture
Description	Golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein).

BPAEA_MOUSE
NC score	0.042725 (rank : 155)	θ value	5.27518 (rank : 107)
Query Neighborhood Hits	155	Target Neighborhood Hits	1480	Shared Neighborhood Hits	75
SwissProt Accessions	Q91ZU8, Q8K5D4	Gene names	Dst, Bpag1
Domain Architecture
Description	Bullous pemphigoid antigen 1, isoform 5 (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Dystonin).

GOGB1_HUMAN
NC score	0.042477 (rank : 156)	θ value	8.99809 (rank : 145)
Query Neighborhood Hits	155	Target Neighborhood Hits	2297	Shared Neighborhood Hits	75
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

PKHA4_MOUSE
NC score	0.042255 (rank : 157)	θ value	0.813845 (rank : 74)
Query Neighborhood Hits	155	Target Neighborhood Hits	202	Shared Neighborhood Hits	5
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CP250_HUMAN
NC score	0.041811 (rank : 158)	θ value	6.88961 (rank : 124)
Query Neighborhood Hits	155	Target Neighborhood Hits	1805	Shared Neighborhood Hits	72
SwissProt Accessions	Q9BV73, O14812, O60588, Q9H450	Gene names	CEP250, CEP2, CNAP1
Domain Architecture
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1).

GRAP1_HUMAN
NC score	0.041646 (rank : 159)	θ value	8.99809 (rank : 146)
Query Neighborhood Hits	155	Target Neighborhood Hits	944	Shared Neighborhood Hits	57
SwissProt Accessions	Q4V328, Q4V327, Q4V330, Q5HYG1, Q6N046, Q96DH8, Q9NQ43, Q9ULQ3	Gene names	GRIPAP1, KIAA1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1).

GRAP1_MOUSE
NC score	0.041112 (rank : 160)	θ value	8.99809 (rank : 147)
Query Neighborhood Hits	155	Target Neighborhood Hits	1234	Shared Neighborhood Hits	60
SwissProt Accessions	Q8VD04, O35693, Q3T9C3, Q69ZP9	Gene names	Gripap1, DXImx47e, Kiaa1167
Domain Architecture	No domain graphic available
Description	GRIP1-associated protein 1 (GRASP-1) (HCMV-interacting protein).

HOOK2_HUMAN
NC score	0.039755 (rank : 161)	θ value	6.88961 (rank : 127)
Query Neighborhood Hits	155	Target Neighborhood Hits	714	Shared Neighborhood Hits	53
SwissProt Accessions	Q96ED9, O60562	Gene names	HOOK2
Domain Architecture
Description	Hook homolog 2 (h-hook2) (hHK2).

LZTS1_MOUSE
NC score	0.038811 (rank : 162)	θ value	6.88961 (rank : 128)
Query Neighborhood Hits	155	Target Neighborhood Hits	540	Shared Neighborhood Hits	51
SwissProt Accessions	P60853	Gene names	Lzts1, Fez1
Domain Architecture	No domain graphic available
Description	Leucine zipper putative tumor suppressor 1 (F37/Esophageal cancer- related gene-coding leucine-zipper motif) (Fez1).

MY18A_HUMAN
NC score	0.038132 (rank : 163)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	155	Target Neighborhood Hits	1929	Shared Neighborhood Hits	75
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

ASPP2_HUMAN
NC score	0.038093 (rank : 164)	θ value	0.813845 (rank : 67)
Query Neighborhood Hits	155	Target Neighborhood Hits	1156	Shared Neighborhood Hits	56
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

MYH9_HUMAN
NC score	0.036987 (rank : 165)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	155	Target Neighborhood Hits	1762	Shared Neighborhood Hits	76
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH3_HUMAN
NC score	0.036326 (rank : 166)	θ value	4.03905 (rank : 103)
Query Neighborhood Hits	155	Target Neighborhood Hits	1660	Shared Neighborhood Hits	73
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

FA50B_HUMAN
NC score	0.035925 (rank : 167)	θ value	1.38821 (rank : 84)
Query Neighborhood Hits	155	Target Neighborhood Hits	130	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y247	Gene names	FAM50B, X5L
Domain Architecture
Description	Protein FAM50B (XAP-5-like protein).

MYH8_MOUSE
NC score	0.035789 (rank : 168)	θ value	8.99809 (rank : 151)
Query Neighborhood Hits	155	Target Neighborhood Hits	1600	Shared Neighborhood Hits	71
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH1_HUMAN
NC score	0.034220 (rank : 169)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	155	Target Neighborhood Hits	1478	Shared Neighborhood Hits	68
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
NC score	0.033696 (rank : 170)	θ value	8.99809 (rank : 150)
Query Neighborhood Hits	155	Target Neighborhood Hits	1461	Shared Neighborhood Hits	67
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

ANR18_HUMAN
NC score	0.031576 (rank : 171)	θ value	6.88961 (rank : 122)
Query Neighborhood Hits	155	Target Neighborhood Hits	1106	Shared Neighborhood Hits	54
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

PKHA4_HUMAN
NC score	0.030369 (rank : 172)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	155	Target Neighborhood Hits	283	Shared Neighborhood Hits	12
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

LMNA_MOUSE
NC score	0.030204 (rank : 173)	θ value	5.27518 (rank : 112)
Query Neighborhood Hits	155	Target Neighborhood Hits	661	Shared Neighborhood Hits	53
SwissProt Accessions	P48678, P11516, P97859, Q3TIH0, Q3TTS8, Q3UCA0, Q3UCJ8, Q91WF2, Q9DC21	Gene names	Lmna, Lmn1
Domain Architecture
Description	Lamin-A/C.

U2AFL_HUMAN
NC score	0.029101 (rank : 174)	θ value	6.88961 (rank : 138)
Query Neighborhood Hits	155	Target Neighborhood Hits	503	Shared Neighborhood Hits	45
SwissProt Accessions	Q15695, Q13570	Gene names	ZRSR1, U2AF1-RS1, U2AF1L1, U2AF1RS1, U2AFBPL
Domain Architecture
Description	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit- related protein 1 (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1) (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1).

LMNA_HUMAN
NC score	0.029081 (rank : 175)	θ value	8.99809 (rank : 149)
Query Neighborhood Hits	155	Target Neighborhood Hits	653	Shared Neighborhood Hits	53
SwissProt Accessions	P02545, P02546, Q969I8, Q96JA2	Gene names	LMNA, LMN1
Domain Architecture
Description	Lamin-A/C (70 kDa lamin) (NY-REN-32 antigen).

WWTR1_MOUSE
NC score	0.028958 (rank : 176)	θ value	4.03905 (rank : 104)
Query Neighborhood Hits	155	Target Neighborhood Hits	54	Shared Neighborhood Hits	4
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

CEBPE_HUMAN
NC score	0.028892 (rank : 177)	θ value	3.0926 (rank : 97)
Query Neighborhood Hits	155	Target Neighborhood Hits	236	Shared Neighborhood Hits	16
SwissProt Accessions	Q15744, Q15745, Q8IYI2, Q99803	Gene names	CEBPE
Domain Architecture
Description	CCAAT/enhancer-binding protein epsilon (C/EBP epsilon).

WWTR1_HUMAN
NC score	0.025554 (rank : 178)	θ value	5.27518 (rank : 119)
Query Neighborhood Hits	155	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

APC_HUMAN
NC score	0.025026 (rank : 179)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	155	Target Neighborhood Hits	603	Shared Neighborhood Hits	34
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

APC_MOUSE
NC score	0.022501 (rank : 180)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	155	Target Neighborhood Hits	441	Shared Neighborhood Hits	30
SwissProt Accessions	Q61315, Q62044	Gene names	Apc
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC) (mAPC).

SH3G1_MOUSE
NC score	0.022373 (rank : 181)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	155	Target Neighborhood Hits	291	Shared Neighborhood Hits	18
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

PSIP1_HUMAN
NC score	0.021957 (rank : 182)	θ value	3.0926 (rank : 100)
Query Neighborhood Hits	155	Target Neighborhood Hits	341	Shared Neighborhood Hits	17
SwissProt Accessions	O75475, O00256, O95368, Q6P391, Q86YB9, Q9NZI3, Q9UER6	Gene names	PSIP1, DFS70, LEDGF, PSIP2
Domain Architecture	No domain graphic available
Description	PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52) (Dense fine speckles 70 kDa protein) (DFS 70) (CLL-associated antigen KW-7).

SH3G1_HUMAN
NC score	0.021815 (rank : 183)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	155	Target Neighborhood Hits	307	Shared Neighborhood Hits	22
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_HUMAN
NC score	0.020542 (rank : 184)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	155	Target Neighborhood Hits	324	Shared Neighborhood Hits	20
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
NC score	0.020369 (rank : 185)	θ value	6.88961 (rank : 137)
Query Neighborhood Hits	155	Target Neighborhood Hits	319	Shared Neighborhood Hits	19
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

K2C4_MOUSE
NC score	0.019484 (rank : 186)	θ value	8.99809 (rank : 148)
Query Neighborhood Hits	155	Target Neighborhood Hits	521	Shared Neighborhood Hits	46
SwissProt Accessions	P07744, Q6P3F5	Gene names	Krt4, Krt2-4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Cytoskeletal 57 kDa keratin).

SAFB1_HUMAN
NC score	0.018616 (rank : 187)	θ value	8.99809 (rank : 154)
Query Neighborhood Hits	155	Target Neighborhood Hits	493	Shared Neighborhood Hits	29
SwissProt Accessions	Q15424, O60406, Q59HH8	Gene names	SAFB, HAP, HET, SAFB1
Domain Architecture
Description	Scaffold attachment factor B (Scaffold attachment factor B1) (SAF-B) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE- TATA-binding protein).

ZHX2_MOUSE
NC score	0.016993 (rank : 188)	θ value	3.0926 (rank : 101)
Query Neighborhood Hits	155	Target Neighborhood Hits	435	Shared Neighborhood Hits	6
SwissProt Accessions	Q8C0C0	Gene names	Zhx2, Afr1, Raf
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

ACTN3_HUMAN
NC score	0.016511 (rank : 189)	θ value	2.36792 (rank : 92)
Query Neighborhood Hits	155	Target Neighborhood Hits	272	Shared Neighborhood Hits	27
SwissProt Accessions	Q08043	Gene names	ACTN3
Domain Architecture
Description	Alpha-actinin-3 (Alpha actinin skeletal muscle isoform 3) (F-actin cross-linking protein).

ROCK1_HUMAN
NC score	0.016184 (rank : 190)	θ value	5.27518 (rank : 118)
Query Neighborhood Hits	155	Target Neighborhood Hits	2000	Shared Neighborhood Hits	66
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

K0240_MOUSE
NC score	0.016183 (rank : 191)	θ value	5.27518 (rank : 110)
Query Neighborhood Hits	155	Target Neighborhood Hits	211	Shared Neighborhood Hits	7
SwissProt Accessions	Q8CHH5	Gene names	Kiaa0240
Domain Architecture	No domain graphic available
Description	Protein KIAA0240.

ZHX2_HUMAN
NC score	0.012403 (rank : 192)	θ value	8.99809 (rank : 155)
Query Neighborhood Hits	155	Target Neighborhood Hits	347	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6X8	Gene names	ZHX2, AFR1, KIAA0854, RAF
Domain Architecture
Description	Zinc fingers and homeoboxes protein 2 (Zinc finger and homeodomain protein 2) (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP).

CKAP2_HUMAN
NC score	0.011779 (rank : 193)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	155	Target Neighborhood Hits	116	Shared Neighborhood Hits	7
SwissProt Accessions	Q8WWK9, Q3KRA5, Q5VXB4, Q8IWV5, Q8IWV6, Q96FH9, Q9H012, Q9H0D0, Q9H988, Q9HC49, Q9NVG4	Gene names	CKAP2, LB1, TMAP
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 2 (Tumor-associated microtubule- associated protein) (CTCL tumor antigen se20-10).

ZO3_MOUSE
NC score	0.010403 (rank : 194)	θ value	5.27518 (rank : 120)
Query Neighborhood Hits	155	Target Neighborhood Hits	224	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QXY1	Gene names	Tjp3, Zo3
Domain Architecture
Description	Tight junction protein ZO-3 (Zonula occludens 3 protein) (Zona occludens 3 protein) (Tight junction protein 3).

ANGP4_HUMAN
NC score	0.010363 (rank : 195)	θ value	6.88961 (rank : 121)
Query Neighborhood Hits	155	Target Neighborhood Hits	187	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y264, Q9H4Z4	Gene names	ANGPT4, ANG3, ANG4
Domain Architecture
Description	Angiopoietin-4 precursor (ANG-4) (ANG-3).

ADIPO_MOUSE
NC score	0.009745 (rank : 196)	θ value	3.0926 (rank : 94)
Query Neighborhood Hits	155	Target Neighborhood Hits	182	Shared Neighborhood Hits	3
SwissProt Accessions	Q60994, Q62400, Q9DC68	Gene names	Adipoq, Acdc, Acrp30, Apm1
Domain Architecture
Description	Adiponectin precursor (Adipocyte, C1q and collagen domain-containing protein) (30 kDa adipocyte complement-related protein) (Adipocyte complement-related 30 kDa protein) (ACRP30) (Adipocyte-specific protein AdipoQ).

LAMA5_MOUSE
NC score	0.008799 (rank : 197)	θ value	5.27518 (rank : 111)
Query Neighborhood Hits	155	Target Neighborhood Hits	828	Shared Neighborhood Hits	36
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

ABCCB_HUMAN
NC score	0.005941 (rank : 198)	θ value	5.27518 (rank : 106)
Query Neighborhood Hits	155	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	Q96J66, Q8TDJ0, Q96JA6, Q9BX80	Gene names	ABCC11, MRP8
Domain Architecture	No domain graphic available
Description	ATP-binding cassette transporter sub-family C member 11 (Multidrug resistance-associated protein 8).

PTPRT_HUMAN
NC score	0.002938 (rank : 199)	θ value	8.99809 (rank : 152)
Query Neighborhood Hits	155	Target Neighborhood Hits	217	Shared Neighborhood Hits	4
SwissProt Accessions	O14522, O43655, O75664, Q5W0X9, Q5W0Y1, Q9BR24, Q9BR28, Q9H0Y8, Q9NTL1, Q9NU72, Q9UBD2, Q9UJL7	Gene names	PTPRT, KIAA0283
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho).

PTPRT_MOUSE
NC score	0.002935 (rank : 200)	θ value	8.99809 (rank : 153)
Query Neighborhood Hits	155	Target Neighborhood Hits	219	Shared Neighborhood Hits	4
SwissProt Accessions	Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0	Gene names	Ptprt
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase T precursor (EC 3.1.3.48) (R-PTP-T) (RPTP-rho) (mRPTPrho) (RPTPmam4).