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Network neighborhood for query Sequence : MAD1_MOUSE

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MAD1_MOUSE
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MAD1_MOUSE
θ value	4.96919e-91 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	75	Target Neighborhood Hits	75	Shared Neighborhood Hits	75
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD1_HUMAN
θ value	1.18825e-76 (rank : 2)	NC score	0.984508 (rank : 2)
Query Neighborhood Hits	75	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MXI1_MOUSE
θ value	4.71619e-41 (rank : 3)	NC score	0.923602 (rank : 4)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	37
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_HUMAN
θ value	1.16164e-39 (rank : 4)	NC score	0.930349 (rank : 3)
Query Neighborhood Hits	75	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD4_HUMAN
θ value	1.85459e-37 (rank : 5)	NC score	0.907110 (rank : 6)
Query Neighborhood Hits	75	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAD4_MOUSE
θ value	5.39604e-37 (rank : 6)	NC score	0.919926 (rank : 5)
Query Neighborhood Hits	75	Target Neighborhood Hits	65	Shared Neighborhood Hits	27
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAD3_HUMAN
θ value	3.3877e-31 (rank : 7)	NC score	0.892487 (rank : 8)
Query Neighborhood Hits	75	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAD3_MOUSE
θ value	3.17079e-29 (rank : 8)	NC score	0.893348 (rank : 7)
Query Neighborhood Hits	75	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MNT_HUMAN
θ value	9.59137e-10 (rank : 9)	NC score	0.470582 (rank : 10)
Query Neighborhood Hits	75	Target Neighborhood Hits	496	Shared Neighborhood Hits	31
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	1.63604e-09 (rank : 10)	NC score	0.488710 (rank : 9)
Query Neighborhood Hits	75	Target Neighborhood Hits	432	Shared Neighborhood Hits	30
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYCN_MOUSE
θ value	0.00869519 (rank : 11)	NC score	0.213767 (rank : 21)
Query Neighborhood Hits	75	Target Neighborhood Hits	125	Shared Neighborhood Hits	35
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

TCFL5_HUMAN
θ value	0.0113563 (rank : 12)	NC score	0.230905 (rank : 19)
Query Neighborhood Hits	75	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

NGN3_HUMAN
θ value	0.0148317 (rank : 13)	NC score	0.100791 (rank : 39)
Query Neighborhood Hits	75	Target Neighborhood Hits	95	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y4Z2, Q9BY24	Gene names	NEUROG3, NGN3
Domain Architecture
Description	Neurogenin 3.

NGN3_MOUSE
θ value	0.0193708 (rank : 14)	NC score	0.099074 (rank : 40)
Query Neighborhood Hits	75	Target Neighborhood Hits	90	Shared Neighborhood Hits	17
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

MAX_HUMAN
θ value	0.0252991 (rank : 15)	NC score	0.275670 (rank : 11)
Query Neighborhood Hits	75	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	0.0252991 (rank : 16)	NC score	0.270051 (rank : 12)
Query Neighborhood Hits	75	Target Neighborhood Hits	139	Shared Neighborhood Hits	38
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

BHLH2_MOUSE
θ value	0.0330416 (rank : 17)	NC score	0.187960 (rank : 27)
Query Neighborhood Hits	75	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

HES1_HUMAN
θ value	0.0330416 (rank : 18)	NC score	0.162803 (rank : 31)
Query Neighborhood Hits	75	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	0.0330416 (rank : 19)	NC score	0.162689 (rank : 32)
Query Neighborhood Hits	75	Target Neighborhood Hits	78	Shared Neighborhood Hits	23
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

MYCL2_HUMAN
θ value	0.0330416 (rank : 20)	NC score	0.219959 (rank : 20)
Query Neighborhood Hits	75	Target Neighborhood Hits	63	Shared Neighborhood Hits	27
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

BHLH3_HUMAN
θ value	0.0431538 (rank : 21)	NC score	0.202430 (rank : 23)
Query Neighborhood Hits	75	Target Neighborhood Hits	106	Shared Neighborhood Hits	28
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

MYCS_MOUSE
θ value	0.0431538 (rank : 22)	NC score	0.172538 (rank : 29)
Query Neighborhood Hits	75	Target Neighborhood Hits	83	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

WBS14_HUMAN
θ value	0.0563607 (rank : 23)	NC score	0.073112 (rank : 47)
Query Neighborhood Hits	75	Target Neighborhood Hits	273	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

BHLH3_MOUSE
θ value	0.0736092 (rank : 24)	NC score	0.195164 (rank : 24)
Query Neighborhood Hits	75	Target Neighborhood Hits	70	Shared Neighborhood Hits	28
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

USF1_HUMAN
θ value	0.125558 (rank : 25)	NC score	0.245433 (rank : 17)
Query Neighborhood Hits	75	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	0.125558 (rank : 26)	NC score	0.245767 (rank : 16)
Query Neighborhood Hits	75	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

HES4_HUMAN
θ value	0.163984 (rank : 27)	NC score	0.133884 (rank : 35)
Query Neighborhood Hits	75	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

NUMA1_HUMAN
θ value	0.163984 (rank : 28)	NC score	0.028749 (rank : 77)
Query Neighborhood Hits	75	Target Neighborhood Hits	1523	Shared Neighborhood Hits	29
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

NRBF2_HUMAN
θ value	0.279714 (rank : 29)	NC score	0.058364 (rank : 65)
Query Neighborhood Hits	75	Target Neighborhood Hits	122	Shared Neighborhood Hits	7
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

BHLH2_HUMAN
θ value	0.62314 (rank : 30)	NC score	0.173739 (rank : 28)
Query Neighborhood Hits	75	Target Neighborhood Hits	80	Shared Neighborhood Hits	30
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

USF2_HUMAN
θ value	0.62314 (rank : 31)	NC score	0.257720 (rank : 13)
Query Neighborhood Hits	75	Target Neighborhood Hits	155	Shared Neighborhood Hits	44
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	0.62314 (rank : 32)	NC score	0.256225 (rank : 14)
Query Neighborhood Hits	75	Target Neighborhood Hits	173	Shared Neighborhood Hits	44
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MYCN_HUMAN
θ value	0.813845 (rank : 33)	NC score	0.208077 (rank : 22)
Query Neighborhood Hits	75	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

KI67_HUMAN
θ value	1.06291 (rank : 34)	NC score	0.028918 (rank : 76)
Query Neighborhood Hits	75	Target Neighborhood Hits	581	Shared Neighborhood Hits	6
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

CENPF_HUMAN
θ value	1.38821 (rank : 35)	NC score	0.020254 (rank : 84)
Query Neighborhood Hits	75	Target Neighborhood Hits	1932	Shared Neighborhood Hits	28
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

MITF_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.161499 (rank : 33)
Query Neighborhood Hits	75	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

SRBP2_HUMAN
θ value	1.81305 (rank : 37)	NC score	0.119221 (rank : 36)
Query Neighborhood Hits	75	Target Neighborhood Hits	133	Shared Neighborhood Hits	32
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

ARNT_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.066470 (rank : 52)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

BEGIN_MOUSE
θ value	2.36792 (rank : 39)	NC score	0.028672 (rank : 78)
Query Neighborhood Hits	75	Target Neighborhood Hits	383	Shared Neighborhood Hits	17
SwissProt Accessions	Q68EF6	Gene names	Begain
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

CF060_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.016245 (rank : 92)
Query Neighborhood Hits	75	Target Neighborhood Hits	1270	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

CP250_MOUSE
θ value	2.36792 (rank : 41)	NC score	0.020101 (rank : 85)
Query Neighborhood Hits	75	Target Neighborhood Hits	1583	Shared Neighborhood Hits	23
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

LRRF2_HUMAN
θ value	2.36792 (rank : 42)	NC score	0.025131 (rank : 81)
Query Neighborhood Hits	75	Target Neighborhood Hits	791	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

LRRF2_MOUSE
θ value	2.36792 (rank : 43)	NC score	0.029423 (rank : 75)
Query Neighborhood Hits	75	Target Neighborhood Hits	556	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

MITF_MOUSE
θ value	2.36792 (rank : 44)	NC score	0.152725 (rank : 34)
Query Neighborhood Hits	75	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

CROCC_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.019602 (rank : 86)
Query Neighborhood Hits	75	Target Neighborhood Hits	1409	Shared Neighborhood Hits	25
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

NGN2_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.061924 (rank : 62)
Query Neighborhood Hits	75	Target Neighborhood Hits	92	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

NGN2_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.060484 (rank : 63)
Query Neighborhood Hits	75	Target Neighborhood Hits	106	Shared Neighborhood Hits	14
SwissProt Accessions	P70447, P70237	Gene names	Neurog2, Ath4a, Atoh4, Ngn2
Domain Architecture
Description	Neurogenin 2 (Atonal protein homolog 4) (Helix-loop-helix protein mATH-4A) (MATH4A).

RHG07_MOUSE
θ value	3.0926 (rank : 48)	NC score	0.010027 (rank : 95)
Query Neighborhood Hits	75	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

BCN1_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.027955 (rank : 80)
Query Neighborhood Hits	75	Target Neighborhood Hits	395	Shared Neighborhood Hits	15
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

BMAL1_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.079114 (rank : 44)
Query Neighborhood Hits	75	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	4.03905 (rank : 51)	NC score	0.077819 (rank : 45)
Query Neighborhood Hits	75	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

FIGLA_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.063817 (rank : 58)
Query Neighborhood Hits	75	Target Neighborhood Hits	100	Shared Neighborhood Hits	19
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

HMMR_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.018706 (rank : 89)
Query Neighborhood Hits	75	Target Neighborhood Hits	1082	Shared Neighborhood Hits	23
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

BCN1_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.028299 (rank : 79)
Query Neighborhood Hits	75	Target Neighborhood Hits	367	Shared Neighborhood Hits	16
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

BHLH8_MOUSE
θ value	5.27518 (rank : 55)	NC score	0.072091 (rank : 48)
Query Neighborhood Hits	75	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

SMC3_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.018897 (rank : 88)
Query Neighborhood Hits	75	Target Neighborhood Hits	1186	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

SMC3_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.018904 (rank : 87)
Query Neighborhood Hits	75	Target Neighborhood Hits	1187	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

ARNT_MOUSE
θ value	6.88961 (rank : 58)	NC score	0.058467 (rank : 64)
Query Neighborhood Hits	75	Target Neighborhood Hits	213	Shared Neighborhood Hits	29
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

FIGLA_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.067910 (rank : 51)
Query Neighborhood Hits	75	Target Neighborhood Hits	108	Shared Neighborhood Hits	21
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

HES2_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.092796 (rank : 41)
Query Neighborhood Hits	75	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

NDF1_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.043864 (rank : 74)
Query Neighborhood Hits	75	Target Neighborhood Hits	186	Shared Neighborhood Hits	16
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

NDF2_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.051714 (rank : 70)
Query Neighborhood Hits	75	Target Neighborhood Hits	113	Shared Neighborhood Hits	18
SwissProt Accessions	Q15784, Q8TBI7, Q9UQC6	Gene names	NEUROD2, NDRF
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF2_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.051677 (rank : 71)
Query Neighborhood Hits	75	Target Neighborhood Hits	111	Shared Neighborhood Hits	18
SwissProt Accessions	Q62414, Q61952, Q925V5	Gene names	Neurod2, Ndrf
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

ROCK1_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.003518 (rank : 97)
Query Neighborhood Hits	75	Target Neighborhood Hits	2000	Shared Neighborhood Hits	23
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

TRHY_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.020897 (rank : 82)
Query Neighborhood Hits	75	Target Neighborhood Hits	1385	Shared Neighborhood Hits	28
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

ARNT2_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.052844 (rank : 67)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.053340 (rank : 66)
Query Neighborhood Hits	75	Target Neighborhood Hits	115	Shared Neighborhood Hits	27
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

K0555_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.016507 (rank : 90)
Query Neighborhood Hits	75	Target Neighborhood Hits	880	Shared Neighborhood Hits	20
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

K1967_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.014943 (rank : 93)
Query Neighborhood Hits	75	Target Neighborhood Hits	136	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VDP4, Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1967 homolog.

KPCI_HUMAN
θ value	8.99809 (rank : 70)	NC score	-0.002268 (rank : 98)
Query Neighborhood Hits	75	Target Neighborhood Hits	885	Shared Neighborhood Hits	3
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).

MYH4_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.009555 (rank : 96)
Query Neighborhood Hits	75	Target Neighborhood Hits	1476	Shared Neighborhood Hits	25
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

NDF1_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.044188 (rank : 73)
Query Neighborhood Hits	75	Target Neighborhood Hits	209	Shared Neighborhood Hits	16
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

NOG2_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.010923 (rank : 94)
Query Neighborhood Hits	75	Target Neighborhood Hits	117	Shared Neighborhood Hits	8
SwissProt Accessions	Q13823, Q9BWN7	Gene names	GNL2, NGP1
Domain Architecture
Description	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

SDCG8_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.020811 (rank : 83)
Query Neighborhood Hits	75	Target Neighborhood Hits	886	Shared Neighborhood Hits	23
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SMC4_HUMAN
θ value	8.99809 (rank : 75)	NC score	0.016450 (rank : 91)
Query Neighborhood Hits	75	Target Neighborhood Hits	937	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

ASCL2_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.050130 (rank : 72)
Query Neighborhood Hits	75	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

BHLH8_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.065051 (rank : 56)
Query Neighborhood Hits	75	Target Neighborhood Hits	123	Shared Neighborhood Hits	24
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

HES2_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.065570 (rank : 55)
Query Neighborhood Hits	75	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.062715 (rank : 60)
Query Neighborhood Hits	75	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES5_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.066073 (rank : 53)
Query Neighborhood Hits	75	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES6_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.052337 (rank : 68)
Query Neighborhood Hits	75	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.051775 (rank : 69)
Query Neighborhood Hits	75	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HEY1_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.064335 (rank : 57)
Query Neighborhood Hits	75	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.065939 (rank : 54)
Query Neighborhood Hits	75	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.070212 (rank : 49)
Query Neighborhood Hits	75	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.070155 (rank : 50)
Query Neighborhood Hits	75	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MLX_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.062415 (rank : 61)
Query Neighborhood Hits	75	Target Neighborhood Hits	95	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.063529 (rank : 59)
Query Neighborhood Hits	75	Target Neighborhood Hits	100	Shared Neighborhood Hits	26
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MYCL1_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.191113 (rank : 25)
Query Neighborhood Hits	75	Target Neighborhood Hits	146	Shared Neighborhood Hits	40
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.190568 (rank : 26)
Query Neighborhood Hits	75	Target Neighborhood Hits	123	Shared Neighborhood Hits	40
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYC_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.239646 (rank : 18)
Query Neighborhood Hits	75	Target Neighborhood Hits	146	Shared Neighborhood Hits	34
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.246176 (rank : 15)
Query Neighborhood Hits	75	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

SRBP1_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.075778 (rank : 46)
Query Neighborhood Hits	75	Target Neighborhood Hits	225	Shared Neighborhood Hits	33
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.092386 (rank : 42)
Query Neighborhood Hits	75	Target Neighborhood Hits	384	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TFAP4_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.083426 (rank : 43)
Query Neighborhood Hits	75	Target Neighborhood Hits	289	Shared Neighborhood Hits	32
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

TFE3_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.166343 (rank : 30)
Query Neighborhood Hits	75	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.115036 (rank : 38)
Query Neighborhood Hits	75	Target Neighborhood Hits	111	Shared Neighborhood Hits	34
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.116047 (rank : 37)
Query Neighborhood Hits	75	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

Hits sorted by NC score

MAD1_MOUSE
NC score	0.999962 (rank : 1)	θ value	4.96919e-91 (rank : 1)
Query Neighborhood Hits	75	Target Neighborhood Hits	75	Shared Neighborhood Hits	75
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD1_HUMAN
NC score	0.984508 (rank : 2)	θ value	1.18825e-76 (rank : 2)
Query Neighborhood Hits	75	Target Neighborhood Hits	68	Shared Neighborhood Hits	45
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MXI1_HUMAN
NC score	0.930349 (rank : 3)	θ value	1.16164e-39 (rank : 4)
Query Neighborhood Hits	75	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
NC score	0.923602 (rank : 4)	θ value	4.71619e-41 (rank : 3)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	37
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD4_MOUSE
NC score	0.919926 (rank : 5)	θ value	5.39604e-37 (rank : 6)
Query Neighborhood Hits	75	Target Neighborhood Hits	65	Shared Neighborhood Hits	27
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAD4_HUMAN
NC score	0.907110 (rank : 6)	θ value	1.85459e-37 (rank : 5)
Query Neighborhood Hits	75	Target Neighborhood Hits	94	Shared Neighborhood Hits	40
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAD3_MOUSE
NC score	0.893348 (rank : 7)	θ value	3.17079e-29 (rank : 8)
Query Neighborhood Hits	75	Target Neighborhood Hits	94	Shared Neighborhood Hits	28
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MAD3_HUMAN
NC score	0.892487 (rank : 8)	θ value	3.3877e-31 (rank : 7)
Query Neighborhood Hits	75	Target Neighborhood Hits	92	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MNT_MOUSE
NC score	0.488710 (rank : 9)	θ value	1.63604e-09 (rank : 10)
Query Neighborhood Hits	75	Target Neighborhood Hits	432	Shared Neighborhood Hits	30
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_HUMAN
NC score	0.470582 (rank : 10)	θ value	9.59137e-10 (rank : 9)
Query Neighborhood Hits	75	Target Neighborhood Hits	496	Shared Neighborhood Hits	31
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MAX_HUMAN
NC score	0.275670 (rank : 11)	θ value	0.0252991 (rank : 15)
Query Neighborhood Hits	75	Target Neighborhood Hits	125	Shared Neighborhood Hits	36
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
NC score	0.270051 (rank : 12)	θ value	0.0252991 (rank : 16)
Query Neighborhood Hits	75	Target Neighborhood Hits	139	Shared Neighborhood Hits	38
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

USF2_HUMAN
NC score	0.257720 (rank : 13)	θ value	0.62314 (rank : 31)
Query Neighborhood Hits	75	Target Neighborhood Hits	155	Shared Neighborhood Hits	44
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
NC score	0.256225 (rank : 14)	θ value	0.62314 (rank : 32)
Query Neighborhood Hits	75	Target Neighborhood Hits	173	Shared Neighborhood Hits	44
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MYC_MOUSE
NC score	0.246176 (rank : 15)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	75	Target Neighborhood Hits	125	Shared Neighborhood Hits	32
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

USF1_MOUSE
NC score	0.245767 (rank : 16)	θ value	0.125558 (rank : 26)
Query Neighborhood Hits	75	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.245433 (rank : 17)	θ value	0.125558 (rank : 25)
Query Neighborhood Hits	75	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MYC_HUMAN
NC score	0.239646 (rank : 18)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	75	Target Neighborhood Hits	146	Shared Neighborhood Hits	34
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

TCFL5_HUMAN
NC score	0.230905 (rank : 19)	θ value	0.0113563 (rank : 12)
Query Neighborhood Hits	75	Target Neighborhood Hits	43	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UL49, O94771, Q9BYW0	Gene names	TCFL5, CHA, E2BP1
Domain Architecture	No domain graphic available
Description	Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1).

MYCL2_HUMAN
NC score	0.219959 (rank : 20)	θ value	0.0330416 (rank : 20)
Query Neighborhood Hits	75	Target Neighborhood Hits	63	Shared Neighborhood Hits	27
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

MYCN_MOUSE
NC score	0.213767 (rank : 21)	θ value	0.00869519 (rank : 11)
Query Neighborhood Hits	75	Target Neighborhood Hits	125	Shared Neighborhood Hits	35
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_HUMAN
NC score	0.208077 (rank : 22)	θ value	0.813845 (rank : 33)
Query Neighborhood Hits	75	Target Neighborhood Hits	127	Shared Neighborhood Hits	34
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

BHLH3_HUMAN
NC score	0.202430 (rank : 23)	θ value	0.0431538 (rank : 21)
Query Neighborhood Hits	75	Target Neighborhood Hits	106	Shared Neighborhood Hits	28
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.195164 (rank : 24)	θ value	0.0736092 (rank : 24)
Query Neighborhood Hits	75	Target Neighborhood Hits	70	Shared Neighborhood Hits	28
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

MYCL1_HUMAN
NC score	0.191113 (rank : 25)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	75	Target Neighborhood Hits	146	Shared Neighborhood Hits	40
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
NC score	0.190568 (rank : 26)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	75	Target Neighborhood Hits	123	Shared Neighborhood Hits	40
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

BHLH2_MOUSE
NC score	0.187960 (rank : 27)	θ value	0.0330416 (rank : 17)
Query Neighborhood Hits	75	Target Neighborhood Hits	70	Shared Neighborhood Hits	29
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH2_HUMAN
NC score	0.173739 (rank : 28)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	75	Target Neighborhood Hits	80	Shared Neighborhood Hits	30
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

MYCS_MOUSE
NC score	0.172538 (rank : 29)	θ value	0.0431538 (rank : 22)
Query Neighborhood Hits	75	Target Neighborhood Hits	83	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

TFE3_HUMAN
NC score	0.166343 (rank : 30)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	75	Target Neighborhood Hits	190	Shared Neighborhood Hits	38
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

HES1_HUMAN
NC score	0.162803 (rank : 31)	θ value	0.0330416 (rank : 18)
Query Neighborhood Hits	75	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
NC score	0.162689 (rank : 32)	θ value	0.0330416 (rank : 19)
Query Neighborhood Hits	75	Target Neighborhood Hits	78	Shared Neighborhood Hits	23
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

MITF_HUMAN
NC score	0.161499 (rank : 33)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	75	Target Neighborhood Hits	113	Shared Neighborhood Hits	36
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.152725 (rank : 34)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	75	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

HES4_HUMAN
NC score	0.133884 (rank : 35)	θ value	0.163984 (rank : 27)
Query Neighborhood Hits	75	Target Neighborhood Hits	58	Shared Neighborhood Hits	25
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

SRBP2_HUMAN
NC score	0.119221 (rank : 36)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	75	Target Neighborhood Hits	133	Shared Neighborhood Hits	32
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

TFEB_MOUSE
NC score	0.116047 (rank : 37)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	75	Target Neighborhood Hits	119	Shared Neighborhood Hits	36
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.115036 (rank : 38)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	75	Target Neighborhood Hits	111	Shared Neighborhood Hits	34
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

NGN3_HUMAN
NC score	0.100791 (rank : 39)	θ value	0.0148317 (rank : 13)
Query Neighborhood Hits	75	Target Neighborhood Hits	95	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Y4Z2, Q9BY24	Gene names	NEUROG3, NGN3
Domain Architecture
Description	Neurogenin 3.

NGN3_MOUSE
NC score	0.099074 (rank : 40)	θ value	0.0193708 (rank : 14)
Query Neighborhood Hits	75	Target Neighborhood Hits	90	Shared Neighborhood Hits	17
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

HES2_MOUSE
NC score	0.092796 (rank : 41)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	75	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

SRBP1_MOUSE
NC score	0.092386 (rank : 42)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	75	Target Neighborhood Hits	384	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TFAP4_HUMAN
NC score	0.083426 (rank : 43)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	75	Target Neighborhood Hits	289	Shared Neighborhood Hits	32
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

BMAL1_HUMAN
NC score	0.079114 (rank : 44)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	75	Target Neighborhood Hits	115	Shared Neighborhood Hits	32
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.077819 (rank : 45)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	75	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

SRBP1_HUMAN
NC score	0.075778 (rank : 46)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	75	Target Neighborhood Hits	225	Shared Neighborhood Hits	33
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

WBS14_HUMAN
NC score	0.073112 (rank : 47)	θ value	0.0563607 (rank : 23)
Query Neighborhood Hits	75	Target Neighborhood Hits	273	Shared Neighborhood Hits	16
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

BHLH8_MOUSE
NC score	0.072091 (rank : 48)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	75	Target Neighborhood Hits	107	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

HEY2_HUMAN
NC score	0.070212 (rank : 49)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	75	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.070155 (rank : 50)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	75	Target Neighborhood Hits	80	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

FIGLA_HUMAN
NC score	0.067910 (rank : 51)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	75	Target Neighborhood Hits	108	Shared Neighborhood Hits	21
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

ARNT_HUMAN
NC score	0.066470 (rank : 52)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

HES5_MOUSE
NC score	0.066073 (rank : 53)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	75	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY1_MOUSE
NC score	0.065939 (rank : 54)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	75	Target Neighborhood Hits	69	Shared Neighborhood Hits	24
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HES2_HUMAN
NC score	0.065570 (rank : 55)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	75	Target Neighborhood Hits	38	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

BHLH8_HUMAN
NC score	0.065051 (rank : 56)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	75	Target Neighborhood Hits	123	Shared Neighborhood Hits	24
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

HEY1_HUMAN
NC score	0.064335 (rank : 57)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	75	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

FIGLA_MOUSE
NC score	0.063817 (rank : 58)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	75	Target Neighborhood Hits	100	Shared Neighborhood Hits	19
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

MLX_MOUSE
NC score	0.063529 (rank : 59)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	75	Target Neighborhood Hits	100	Shared Neighborhood Hits	26
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

HES3_MOUSE
NC score	0.062715 (rank : 60)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	75	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

MLX_HUMAN
NC score	0.062415 (rank : 61)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	75	Target Neighborhood Hits	95	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

NGN2_HUMAN
NC score	0.061924 (rank : 62)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	75	Target Neighborhood Hits	92	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

NGN2_MOUSE
NC score	0.060484 (rank : 63)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	75	Target Neighborhood Hits	106	Shared Neighborhood Hits	14
SwissProt Accessions	P70447, P70237	Gene names	Neurog2, Ath4a, Atoh4, Ngn2
Domain Architecture
Description	Neurogenin 2 (Atonal protein homolog 4) (Helix-loop-helix protein mATH-4A) (MATH4A).

ARNT_MOUSE
NC score	0.058467 (rank : 64)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	75	Target Neighborhood Hits	213	Shared Neighborhood Hits	29
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

NRBF2_HUMAN
NC score	0.058364 (rank : 65)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	75	Target Neighborhood Hits	122	Shared Neighborhood Hits	7
SwissProt Accessions	Q96F24, Q86UR2, Q96NP6, Q9H0S9, Q9H2I2	Gene names	NRBF2, COPR
Domain Architecture	No domain graphic available
Description	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR).

ARNT2_MOUSE
NC score	0.053340 (rank : 66)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	75	Target Neighborhood Hits	115	Shared Neighborhood Hits	27
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.052844 (rank : 67)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	75	Target Neighborhood Hits	109	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

HES6_HUMAN
NC score	0.052337 (rank : 68)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	75	Target Neighborhood Hits	49	Shared Neighborhood Hits	10
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.051775 (rank : 69)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	75	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

NDF2_HUMAN
NC score	0.051714 (rank : 70)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	75	Target Neighborhood Hits	113	Shared Neighborhood Hits	18
SwissProt Accessions	Q15784, Q8TBI7, Q9UQC6	Gene names	NEUROD2, NDRF
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF2_MOUSE
NC score	0.051677 (rank : 71)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	75	Target Neighborhood Hits	111	Shared Neighborhood Hits	18
SwissProt Accessions	Q62414, Q61952, Q925V5	Gene names	Neurod2, Ndrf
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

ASCL2_MOUSE
NC score	0.050130 (rank : 72)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	75	Target Neighborhood Hits	98	Shared Neighborhood Hits	19
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

NDF1_MOUSE
NC score	0.044188 (rank : 73)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	75	Target Neighborhood Hits	209	Shared Neighborhood Hits	16
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

NDF1_HUMAN
NC score	0.043864 (rank : 74)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	75	Target Neighborhood Hits	186	Shared Neighborhood Hits	16
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

LRRF2_MOUSE
NC score	0.029423 (rank : 75)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	75	Target Neighborhood Hits	556	Shared Neighborhood Hits	17
SwissProt Accessions	Q91WK0, Q8BVD1, Q9CU89	Gene names	Lrrfip2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

KI67_HUMAN
NC score	0.028918 (rank : 76)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	75	Target Neighborhood Hits	581	Shared Neighborhood Hits	6
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

NUMA1_HUMAN
NC score	0.028749 (rank : 77)	θ value	0.163984 (rank : 28)
Query Neighborhood Hits	75	Target Neighborhood Hits	1523	Shared Neighborhood Hits	29
SwissProt Accessions	Q14980, Q14981	Gene names	NUMA1, NUMA
Domain Architecture	No domain graphic available
Description	Nuclear mitotic apparatus protein 1 (NuMA protein) (SP-H antigen).

BEGIN_MOUSE
NC score	0.028672 (rank : 78)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	75	Target Neighborhood Hits	383	Shared Neighborhood Hits	17
SwissProt Accessions	Q68EF6	Gene names	Begain
Domain Architecture	No domain graphic available
Description	Brain-enriched guanylate kinase-associated protein.

BCN1_MOUSE
NC score	0.028299 (rank : 79)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	75	Target Neighborhood Hits	367	Shared Neighborhood Hits	16
SwissProt Accessions	O88597	Gene names	Becn1
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein).

BCN1_HUMAN
NC score	0.027955 (rank : 80)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	75	Target Neighborhood Hits	395	Shared Neighborhood Hits	15
SwissProt Accessions	Q14457, O75595, Q9UNA8	Gene names	BECN1, GT197
Domain Architecture
Description	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197).

LRRF2_HUMAN
NC score	0.025131 (rank : 81)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	75	Target Neighborhood Hits	791	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y608, Q68CV3, Q9NXH5	Gene names	LRRFIP2
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2).

TRHY_HUMAN
NC score	0.020897 (rank : 82)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	75	Target Neighborhood Hits	1385	Shared Neighborhood Hits	28
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

SDCG8_MOUSE
NC score	0.020811 (rank : 83)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	75	Target Neighborhood Hits	886	Shared Neighborhood Hits	23
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

CENPF_HUMAN
NC score	0.020254 (rank : 84)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	75	Target Neighborhood Hits	1932	Shared Neighborhood Hits	28
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CP250_MOUSE
NC score	0.020101 (rank : 85)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	75	Target Neighborhood Hits	1583	Shared Neighborhood Hits	23
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

CROCC_HUMAN
NC score	0.019602 (rank : 86)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	75	Target Neighborhood Hits	1409	Shared Neighborhood Hits	25
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

SMC3_MOUSE
NC score	0.018904 (rank : 87)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	75	Target Neighborhood Hits	1187	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CW03, O35667, Q9QUS3	Gene names	Cspg6, Bam, Bmh, Mmip1, Smc3, Smc3l1, Smcd
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome segregation protein SmcD) (Bamacan) (Basement membrane-associated chondroitin proteoglycan) (Mad member- interacting protein 1).

SMC3_HUMAN
NC score	0.018897 (rank : 88)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	75	Target Neighborhood Hits	1186	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UQE7, O60464	Gene names	CSPG6, BAM, BMH, SMC3, SMC3L1
Domain Architecture
Description	Structural maintenance of chromosome 3 (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) (Bamacan) (Basement membrane-associated chondroitin proteoglycan).

HMMR_HUMAN
NC score	0.018706 (rank : 89)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	75	Target Neighborhood Hits	1082	Shared Neighborhood Hits	23
SwissProt Accessions	O75330, Q92767	Gene names	HMMR, IHABP, RHAMM
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility) (CD168 antigen).

K0555_HUMAN
NC score	0.016507 (rank : 90)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	75	Target Neighborhood Hits	880	Shared Neighborhood Hits	20
SwissProt Accessions	Q96AA8, O60302	Gene names	KIAA0555
Domain Architecture	No domain graphic available
Description	Protein KIAA0555.

SMC4_HUMAN
NC score	0.016450 (rank : 91)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	75	Target Neighborhood Hits	937	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

CF060_HUMAN
NC score	0.016245 (rank : 92)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	75	Target Neighborhood Hits	1270	Shared Neighborhood Hits	18
SwissProt Accessions	Q8NB25, Q96GY8, Q9H851	Gene names	C6orf60
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf60.

K1967_MOUSE
NC score	0.014943 (rank : 93)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	75	Target Neighborhood Hits	136	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VDP4, Q6PIB1, Q8BWR5, Q8C0F0, Q8R3G6	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1967 homolog.

NOG2_HUMAN
NC score	0.010923 (rank : 94)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	75	Target Neighborhood Hits	117	Shared Neighborhood Hits	8
SwissProt Accessions	Q13823, Q9BWN7	Gene names	GNL2, NGP1
Domain Architecture
Description	Nucleolar GTP-binding protein 2 (Autoantigen NGP-1).

RHG07_MOUSE
NC score	0.010027 (rank : 95)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	75	Target Neighborhood Hits	103	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

MYH4_MOUSE
NC score	0.009555 (rank : 96)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	75	Target Neighborhood Hits	1476	Shared Neighborhood Hits	25
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

ROCK1_HUMAN
NC score	0.003518 (rank : 97)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	75	Target Neighborhood Hits	2000	Shared Neighborhood Hits	23
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

KPCI_HUMAN
NC score	-0.002268 (rank : 98)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	75	Target Neighborhood Hits	885	Shared Neighborhood Hits	3
SwissProt Accessions	P41743, Q8WW06	Gene names	PRKCI, DXS1179E
Domain Architecture
Description	Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota) (Atypical protein kinase C-lambda/iota) (aPKC-lambda/iota) (PRKC-lambda/iota).