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Network neighborhood for query Sequence : BHLH8_HUMAN

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BHLH8_HUMAN
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BHLH8_HUMAN
θ value	8.22888e-78 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	123	Target Neighborhood Hits	123	Shared Neighborhood Hits	123
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
θ value	9.45883e-58 (rank : 2)	NC score	0.992662 (rank : 2)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	104
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

NGN2_MOUSE
θ value	2.0648e-12 (rank : 3)	NC score	0.869262 (rank : 3)
Query Neighborhood Hits	123	Target Neighborhood Hits	106	Shared Neighborhood Hits	77
SwissProt Accessions	P70447, P70237	Gene names	Neurog2, Ath4a, Atoh4, Ngn2
Domain Architecture
Description	Neurogenin 2 (Atonal protein homolog 4) (Helix-loop-helix protein mATH-4A) (MATH4A).

ATOH1_HUMAN
θ value	1.02475e-11 (rank : 4)	NC score	0.809856 (rank : 11)
Query Neighborhood Hits	123	Target Neighborhood Hits	97	Shared Neighborhood Hits	81
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

ATOH1_MOUSE
θ value	3.89403e-11 (rank : 5)	NC score	0.805285 (rank : 14)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	83
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

NGN3_HUMAN
θ value	3.89403e-11 (rank : 6)	NC score	0.864161 (rank : 5)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y4Z2, Q9BY24	Gene names	NEUROG3, NGN3
Domain Architecture
Description	Neurogenin 3.

NGN2_HUMAN
θ value	5.08577e-11 (rank : 7)	NC score	0.867001 (rank : 4)
Query Neighborhood Hits	123	Target Neighborhood Hits	92	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

NGN1_HUMAN
θ value	1.9326e-10 (rank : 8)	NC score	0.857721 (rank : 7)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	77
SwissProt Accessions	Q92886, Q96HE1	Gene names	NEUROG1, NEUROD3, NGN, NGN1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein).

NGN1_MOUSE
θ value	1.9326e-10 (rank : 9)	NC score	0.855564 (rank : 8)
Query Neighborhood Hits	123	Target Neighborhood Hits	87	Shared Neighborhood Hits	77
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

NGN3_MOUSE
θ value	2.52405e-10 (rank : 10)	NC score	0.861977 (rank : 6)
Query Neighborhood Hits	123	Target Neighborhood Hits	90	Shared Neighborhood Hits	84
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

NDF6_HUMAN
θ value	1.25267e-09 (rank : 11)	NC score	0.738015 (rank : 40)
Query Neighborhood Hits	123	Target Neighborhood Hits	91	Shared Neighborhood Hits	74
SwissProt Accessions	Q96NK8, Q9H3H6	Gene names	NEUROD6
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6).

NDF6_MOUSE
θ value	1.25267e-09 (rank : 12)	NC score	0.738122 (rank : 39)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	74
SwissProt Accessions	P48986	Gene names	Neurod6, Ath2, Atoh2, Nex1
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6) (Atonal protein homolog 2) (Helix-loop-helix protein mATH-2) (MATH2) (NEX-1 protein).

NDF1_HUMAN
θ value	2.79066e-09 (rank : 13)	NC score	0.767829 (rank : 29)
Query Neighborhood Hits	123	Target Neighborhood Hits	186	Shared Neighborhood Hits	78
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

NDF1_MOUSE
θ value	2.79066e-09 (rank : 14)	NC score	0.763250 (rank : 31)
Query Neighborhood Hits	123	Target Neighborhood Hits	209	Shared Neighborhood Hits	78
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

NDF2_HUMAN
θ value	3.64472e-09 (rank : 15)	NC score	0.788019 (rank : 23)
Query Neighborhood Hits	123	Target Neighborhood Hits	113	Shared Neighborhood Hits	85
SwissProt Accessions	Q15784, Q8TBI7, Q9UQC6	Gene names	NEUROD2, NDRF
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF2_MOUSE
θ value	3.64472e-09 (rank : 16)	NC score	0.788000 (rank : 24)
Query Neighborhood Hits	123	Target Neighborhood Hits	111	Shared Neighborhood Hits	85
SwissProt Accessions	Q62414, Q61952, Q925V5	Gene names	Neurod2, Ndrf
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF4_MOUSE
θ value	3.64472e-09 (rank : 17)	NC score	0.777905 (rank : 27)
Query Neighborhood Hits	123	Target Neighborhood Hits	105	Shared Neighborhood Hits	83
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

NDF4_HUMAN
θ value	6.21693e-09 (rank : 18)	NC score	0.779283 (rank : 26)
Query Neighborhood Hits	123	Target Neighborhood Hits	91	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HD90	Gene names	NEUROD4
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4).

OLIG3_HUMAN
θ value	6.21693e-09 (rank : 19)	NC score	0.722455 (rank : 48)
Query Neighborhood Hits	123	Target Neighborhood Hits	77	Shared Neighborhood Hits	59
SwissProt Accessions	Q7RTU3, Q8N8Q0	Gene names	OLIG3, BHLHB7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Basic helix-loop- helix domain-containing class B protein 7).

OLIG3_MOUSE
θ value	6.21693e-09 (rank : 20)	NC score	0.728191 (rank : 46)
Query Neighborhood Hits	123	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q6PFG8, Q9EQW5	Gene names	Olig3, Bhlhb7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Oligodendrocyte- specific bHLH transcription factor 3) (Basic helix-loop-helix domain- containing class B protein 7).

OLIG2_HUMAN
θ value	1.38499e-08 (rank : 21)	NC score	0.728984 (rank : 45)
Query Neighborhood Hits	123	Target Neighborhood Hits	84	Shared Neighborhood Hits	64
SwissProt Accessions	Q13516, Q86X04, Q9NZ14	Gene names	OLIG2, BHLHB1, PRKCBP2, RACK17
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2) (Basic helix-loop- helix protein class B 1) (Protein kinase C-binding protein RACK17) (Protein kinase C-binding protein 2).

OLIG2_MOUSE
θ value	1.38499e-08 (rank : 22)	NC score	0.731667 (rank : 44)
Query Neighborhood Hits	123	Target Neighborhood Hits	74	Shared Neighborhood Hits	62
SwissProt Accessions	Q9EQW6, Q9JKN4	Gene names	Olig2
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2).

OLIG1_MOUSE
θ value	3.08544e-08 (rank : 23)	NC score	0.700671 (rank : 57)
Query Neighborhood Hits	123	Target Neighborhood Hits	69	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JKN5	Gene names	Olig1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1) (Oligodendrocyte- specific bHLH transcription factor 1).

HAND2_HUMAN
θ value	4.0297e-08 (rank : 24)	NC score	0.791729 (rank : 20)
Query Neighborhood Hits	123	Target Neighborhood Hits	99	Shared Neighborhood Hits	93
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
θ value	4.0297e-08 (rank : 25)	NC score	0.791729 (rank : 21)
Query Neighborhood Hits	123	Target Neighborhood Hits	99	Shared Neighborhood Hits	93
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

PTF1A_MOUSE
θ value	6.87365e-08 (rank : 26)	NC score	0.808447 (rank : 12)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	91
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

SCX_MOUSE
θ value	6.87365e-08 (rank : 27)	NC score	0.844503 (rank : 9)
Query Neighborhood Hits	123	Target Neighborhood Hits	82	Shared Neighborhood Hits	82
SwissProt Accessions	Q64124	Gene names	Scx
Domain Architecture
Description	Basic helix-loop-helix transcription factor scleraxis.

TCF15_MOUSE
θ value	6.87365e-08 (rank : 28)	NC score	0.806113 (rank : 13)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	76
SwissProt Accessions	Q60756, Q60788	Gene names	Tcf15, Bhlhec2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis) (Meso1).

LYL1_MOUSE
θ value	8.97725e-08 (rank : 29)	NC score	0.766212 (rank : 30)
Query Neighborhood Hits	123	Target Neighborhood Hits	102	Shared Neighborhood Hits	90
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

TCF15_HUMAN
θ value	8.97725e-08 (rank : 30)	NC score	0.797643 (rank : 19)
Query Neighborhood Hits	123	Target Neighborhood Hits	79	Shared Neighborhood Hits	73
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

BHLH4_HUMAN
θ value	1.17247e-07 (rank : 31)	NC score	0.759657 (rank : 32)
Query Neighborhood Hits	123	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NDY6	Gene names	BHLHB4
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

BHLH4_MOUSE
θ value	1.17247e-07 (rank : 32)	NC score	0.750535 (rank : 34)
Query Neighborhood Hits	123	Target Neighborhood Hits	71	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BGW3, Q71MB7	Gene names	Bhlhb4, H20
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

TWST2_HUMAN
θ value	1.17247e-07 (rank : 33)	NC score	0.803548 (rank : 18)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	91
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_MOUSE
θ value	1.17247e-07 (rank : 34)	NC score	0.803792 (rank : 17)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	91
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

ASCL2_MOUSE
θ value	1.99992e-07 (rank : 35)	NC score	0.734443 (rank : 43)
Query Neighborhood Hits	123	Target Neighborhood Hits	98	Shared Neighborhood Hits	85
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

PTF1A_HUMAN
θ value	1.99992e-07 (rank : 36)	NC score	0.815151 (rank : 10)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	91
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

ASCL2_HUMAN
θ value	2.61198e-07 (rank : 37)	NC score	0.756153 (rank : 33)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	84
SwissProt Accessions	Q99929, Q9UM68	Gene names	ASCL2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash2) (HASH2).

LYL1_HUMAN
θ value	3.41135e-07 (rank : 38)	NC score	0.770526 (rank : 28)
Query Neighborhood Hits	123	Target Neighborhood Hits	113	Shared Neighborhood Hits	90
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

TAL2_MOUSE
θ value	9.92553e-07 (rank : 39)	NC score	0.788339 (rank : 22)
Query Neighborhood Hits	123	Target Neighborhood Hits	79	Shared Neighborhood Hits	78
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

HAND1_HUMAN
θ value	1.29631e-06 (rank : 40)	NC score	0.750054 (rank : 35)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	89
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HAND1_MOUSE
θ value	1.29631e-06 (rank : 41)	NC score	0.747531 (rank : 36)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	91
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

TAL1_HUMAN
θ value	1.29631e-06 (rank : 42)	NC score	0.737632 (rank : 41)
Query Neighborhood Hits	123	Target Neighborhood Hits	112	Shared Neighborhood Hits	89
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

TAL1_MOUSE
θ value	1.29631e-06 (rank : 43)	NC score	0.738693 (rank : 38)
Query Neighborhood Hits	123	Target Neighborhood Hits	110	Shared Neighborhood Hits	89
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

TWST1_HUMAN
θ value	1.29631e-06 (rank : 44)	NC score	0.804479 (rank : 16)
Query Neighborhood Hits	123	Target Neighborhood Hits	93	Shared Neighborhood Hits	91
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
θ value	1.29631e-06 (rank : 45)	NC score	0.804523 (rank : 15)
Query Neighborhood Hits	123	Target Neighborhood Hits	101	Shared Neighborhood Hits	93
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

TAL2_HUMAN
θ value	3.77169e-06 (rank : 46)	NC score	0.786776 (rank : 25)
Query Neighborhood Hits	123	Target Neighborhood Hits	77	Shared Neighborhood Hits	75
SwissProt Accessions	Q16559	Gene names	TAL2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein (TAL-2 protein).

OLIG1_HUMAN
θ value	6.43352e-06 (rank : 47)	NC score	0.708481 (rank : 53)
Query Neighborhood Hits	123	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TAK6, Q7RTS0	Gene names	OLIG1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1).

ASCL1_HUMAN
θ value	1.09739e-05 (rank : 48)	NC score	0.693544 (rank : 59)
Query Neighborhood Hits	123	Target Neighborhood Hits	94	Shared Neighborhood Hits	87
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

ASCL1_MOUSE
θ value	1.09739e-05 (rank : 49)	NC score	0.695328 (rank : 58)
Query Neighborhood Hits	123	Target Neighborhood Hits	97	Shared Neighborhood Hits	87
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

TCF21_HUMAN
θ value	1.87187e-05 (rank : 50)	NC score	0.708222 (rank : 54)
Query Neighborhood Hits	123	Target Neighborhood Hits	68	Shared Neighborhood Hits	67
SwissProt Accessions	O43680, O43545, Q9BZ14	Gene names	TCF21, POD1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

TCF21_MOUSE
θ value	1.87187e-05 (rank : 51)	NC score	0.704355 (rank : 56)
Query Neighborhood Hits	123	Target Neighborhood Hits	69	Shared Neighborhood Hits	67
SwissProt Accessions	O35437, Q3U023	Gene names	Tcf21, Pod1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

MUSC_HUMAN
θ value	3.19293e-05 (rank : 52)	NC score	0.715332 (rank : 50)
Query Neighborhood Hits	123	Target Neighborhood Hits	78	Shared Neighborhood Hits	71
SwissProt Accessions	O60682, O75946, Q9BRE7	Gene names	MSC, ABF1
Domain Architecture
Description	Musculin (Activated B-cell factor 1) (ABF-1).

MUSC_MOUSE
θ value	3.19293e-05 (rank : 53)	NC score	0.726137 (rank : 47)
Query Neighborhood Hits	123	Target Neighborhood Hits	78	Shared Neighborhood Hits	71
SwissProt Accessions	O88940	Gene names	Msc, Myor
Domain Architecture
Description	Musculin (Myogenic repressor).

ASCL3_HUMAN
θ value	0.000270298 (rank : 54)	NC score	0.643978 (rank : 61)
Query Neighborhood Hits	123	Target Neighborhood Hits	70	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NQ33, Q8WYQ6	Gene names	ASCL3, HASH3, SGN1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1).

ASCL3_MOUSE
θ value	0.000461057 (rank : 55)	NC score	0.656755 (rank : 60)
Query Neighborhood Hits	123	Target Neighborhood Hits	70	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JJR7	Gene names	Ascl3, Mash3, Sgn1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1) (Mash- 3).

HEN1_HUMAN
θ value	0.00102713 (rank : 56)	NC score	0.743206 (rank : 37)
Query Neighborhood Hits	123	Target Neighborhood Hits	88	Shared Neighborhood Hits	75
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_MOUSE
θ value	0.00102713 (rank : 57)	NC score	0.736271 (rank : 42)
Query Neighborhood Hits	123	Target Neighborhood Hits	86	Shared Neighborhood Hits	75
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN2_HUMAN
θ value	0.00102713 (rank : 58)	NC score	0.717977 (rank : 49)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	76
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HEN2_MOUSE
θ value	0.00102713 (rank : 59)	NC score	0.715096 (rank : 51)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	76
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

FIGLA_HUMAN
θ value	0.00228821 (rank : 60)	NC score	0.711107 (rank : 52)
Query Neighborhood Hits	123	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

FIGLA_MOUSE
θ value	0.00298849 (rank : 61)	NC score	0.704445 (rank : 55)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	93
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

MYOG_HUMAN
θ value	0.00390308 (rank : 62)	NC score	0.350975 (rank : 69)
Query Neighborhood Hits	123	Target Neighborhood Hits	67	Shared Neighborhood Hits	55
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
θ value	0.00390308 (rank : 63)	NC score	0.348179 (rank : 70)
Query Neighborhood Hits	123	Target Neighborhood Hits	71	Shared Neighborhood Hits	55
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

TFAP4_HUMAN
θ value	0.00390308 (rank : 64)	NC score	0.476784 (rank : 62)
Query Neighborhood Hits	123	Target Neighborhood Hits	289	Shared Neighborhood Hits	75
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

MYCS_MOUSE
θ value	0.00665767 (rank : 65)	NC score	0.260915 (rank : 76)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYCN_HUMAN
θ value	0.0113563 (rank : 66)	NC score	0.241005 (rank : 79)
Query Neighborhood Hits	123	Target Neighborhood Hits	127	Shared Neighborhood Hits	46
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_MOUSE
θ value	0.0113563 (rank : 67)	NC score	0.260937 (rank : 75)
Query Neighborhood Hits	123	Target Neighborhood Hits	125	Shared Neighborhood Hits	49
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

USF2_HUMAN
θ value	0.0148317 (rank : 68)	NC score	0.157255 (rank : 94)
Query Neighborhood Hits	123	Target Neighborhood Hits	155	Shared Neighborhood Hits	31
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	0.0148317 (rank : 69)	NC score	0.157350 (rank : 93)
Query Neighborhood Hits	123	Target Neighborhood Hits	173	Shared Neighborhood Hits	31
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

MYCN_MOUSE
θ value	0.0252991 (rank : 70)	NC score	0.246360 (rank : 77)
Query Neighborhood Hits	123	Target Neighborhood Hits	125	Shared Neighborhood Hits	45
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_HUMAN
θ value	0.0252991 (rank : 71)	NC score	0.245535 (rank : 78)
Query Neighborhood Hits	123	Target Neighborhood Hits	146	Shared Neighborhood Hits	49
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYF5_HUMAN
θ value	0.0431538 (rank : 72)	NC score	0.436196 (rank : 64)
Query Neighborhood Hits	123	Target Neighborhood Hits	80	Shared Neighborhood Hits	69
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYF5_MOUSE
θ value	0.0431538 (rank : 73)	NC score	0.444171 (rank : 63)
Query Neighborhood Hits	123	Target Neighborhood Hits	77	Shared Neighborhood Hits	69
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYOD1_HUMAN
θ value	0.0431538 (rank : 74)	NC score	0.396835 (rank : 66)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	66
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOD1_MOUSE
θ value	0.0431538 (rank : 75)	NC score	0.398718 (rank : 65)
Query Neighborhood Hits	123	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

OGFR_HUMAN
θ value	0.0431538 (rank : 76)	NC score	0.022143 (rank : 121)
Query Neighborhood Hits	123	Target Neighborhood Hits	1582	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

ITF2_HUMAN
θ value	0.0736092 (rank : 77)	NC score	0.190246 (rank : 87)
Query Neighborhood Hits	123	Target Neighborhood Hits	168	Shared Neighborhood Hits	51
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ITF2_MOUSE
θ value	0.0736092 (rank : 78)	NC score	0.190999 (rank : 86)
Query Neighborhood Hits	123	Target Neighborhood Hits	154	Shared Neighborhood Hits	51
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

MNT_HUMAN
θ value	0.0961366 (rank : 79)	NC score	0.181248 (rank : 89)
Query Neighborhood Hits	123	Target Neighborhood Hits	496	Shared Neighborhood Hits	50
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MNT_MOUSE
θ value	0.0961366 (rank : 80)	NC score	0.192750 (rank : 85)
Query Neighborhood Hits	123	Target Neighborhood Hits	432	Shared Neighborhood Hits	55
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

ID1_HUMAN
θ value	0.163984 (rank : 81)	NC score	0.306545 (rank : 72)
Query Neighborhood Hits	123	Target Neighborhood Hits	63	Shared Neighborhood Hits	59
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

MYCL1_HUMAN
θ value	0.163984 (rank : 82)	NC score	0.193609 (rank : 84)
Query Neighborhood Hits	123	Target Neighborhood Hits	146	Shared Neighborhood Hits	45
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	0.163984 (rank : 83)	NC score	0.189271 (rank : 88)
Query Neighborhood Hits	123	Target Neighborhood Hits	123	Shared Neighborhood Hits	40
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYF6_HUMAN
θ value	0.163984 (rank : 84)	NC score	0.388323 (rank : 67)
Query Neighborhood Hits	123	Target Neighborhood Hits	74	Shared Neighborhood Hits	60
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
θ value	0.163984 (rank : 85)	NC score	0.386087 (rank : 68)
Query Neighborhood Hits	123	Target Neighborhood Hits	72	Shared Neighborhood Hits	59
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

IASPP_MOUSE
θ value	0.279714 (rank : 86)	NC score	0.013759 (rank : 125)
Query Neighborhood Hits	123	Target Neighborhood Hits	1024	Shared Neighborhood Hits	11
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

PRRT3_HUMAN
θ value	0.279714 (rank : 87)	NC score	0.026597 (rank : 119)
Query Neighborhood Hits	123	Target Neighborhood Hits	998	Shared Neighborhood Hits	17
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SPEG_HUMAN
θ value	0.279714 (rank : 88)	NC score	-0.000327 (rank : 134)
Query Neighborhood Hits	123	Target Neighborhood Hits	1762	Shared Neighborhood Hits	15
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

USF1_HUMAN
θ value	0.47712 (rank : 89)	NC score	0.121108 (rank : 99)
Query Neighborhood Hits	123	Target Neighborhood Hits	70	Shared Neighborhood Hits	24
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

CGRE1_HUMAN
θ value	0.62314 (rank : 90)	NC score	0.032439 (rank : 118)
Query Neighborhood Hits	123	Target Neighborhood Hits	354	Shared Neighborhood Hits	10
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

MAX_HUMAN
θ value	0.813845 (rank : 91)	NC score	0.214991 (rank : 83)
Query Neighborhood Hits	123	Target Neighborhood Hits	125	Shared Neighborhood Hits	42
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	0.813845 (rank : 92)	NC score	0.217363 (rank : 81)
Query Neighborhood Hits	123	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

HTF4_HUMAN
θ value	1.06291 (rank : 93)	NC score	0.166039 (rank : 91)
Query Neighborhood Hits	123	Target Neighborhood Hits	152	Shared Neighborhood Hits	52
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

HTF4_MOUSE
θ value	1.06291 (rank : 94)	NC score	0.171797 (rank : 90)
Query Neighborhood Hits	123	Target Neighborhood Hits	153	Shared Neighborhood Hits	54
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

ID2_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.237671 (rank : 80)
Query Neighborhood Hits	123	Target Neighborhood Hits	48	Shared Neighborhood Hits	47
SwissProt Accessions	Q02363	Gene names	ID2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

CT151_HUMAN
θ value	1.38821 (rank : 96)	NC score	0.026167 (rank : 120)
Query Neighborhood Hits	123	Target Neighborhood Hits	382	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

HEY2_HUMAN
θ value	1.38821 (rank : 97)	NC score	0.077053 (rank : 105)
Query Neighborhood Hits	123	Target Neighborhood Hits	77	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	1.38821 (rank : 98)	NC score	0.083304 (rank : 102)
Query Neighborhood Hits	123	Target Neighborhood Hits	80	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

ID1_MOUSE
θ value	1.38821 (rank : 99)	NC score	0.280283 (rank : 74)
Query Neighborhood Hits	123	Target Neighborhood Hits	64	Shared Neighborhood Hits	59
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

NTBP1_MOUSE
θ value	1.38821 (rank : 100)	NC score	0.015712 (rank : 124)
Query Neighborhood Hits	123	Target Neighborhood Hits	528	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

S39A5_MOUSE
θ value	1.38821 (rank : 101)	NC score	0.021234 (rank : 122)
Query Neighborhood Hits	123	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D856, Q9D909	Gene names	Slc39a5, Zip5
Domain Architecture	No domain graphic available
Description	Zinc transporter ZIP5 precursor (Solute carrier family 39 member 5).

USF1_MOUSE
θ value	1.38821 (rank : 102)	NC score	0.119114 (rank : 100)
Query Neighborhood Hits	123	Target Neighborhood Hits	71	Shared Neighborhood Hits	24
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

ID2_MOUSE
θ value	2.36792 (rank : 103)	NC score	0.217112 (rank : 82)
Query Neighborhood Hits	123	Target Neighborhood Hits	47	Shared Neighborhood Hits	46
SwissProt Accessions	P41136, O88604	Gene names	Id2, Id-2, Idb2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

ID4_HUMAN
θ value	2.36792 (rank : 104)	NC score	0.309717 (rank : 71)
Query Neighborhood Hits	123	Target Neighborhood Hits	67	Shared Neighborhood Hits	65
SwissProt Accessions	P47928, Q13005	Gene names	ID4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID4_MOUSE
θ value	2.36792 (rank : 105)	NC score	0.304412 (rank : 73)
Query Neighborhood Hits	123	Target Neighborhood Hits	66	Shared Neighborhood Hits	65
SwissProt Accessions	P41139	Gene names	Id4, Id-4, Idb4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

MAD3_HUMAN
θ value	2.36792 (rank : 106)	NC score	0.057991 (rank : 113)
Query Neighborhood Hits	123	Target Neighborhood Hits	92	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

TFE2_HUMAN
θ value	2.36792 (rank : 107)	NC score	0.157835 (rank : 92)
Query Neighborhood Hits	123	Target Neighborhood Hits	161	Shared Neighborhood Hits	47
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

AIRE_MOUSE
θ value	3.0926 (rank : 108)	NC score	0.010350 (rank : 128)
Query Neighborhood Hits	123	Target Neighborhood Hits	196	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

CO6A2_HUMAN
θ value	3.0926 (rank : 109)	NC score	0.011807 (rank : 126)
Query Neighborhood Hits	123	Target Neighborhood Hits	249	Shared Neighborhood Hits	8
SwissProt Accessions	P12110, Q13909, Q13910, Q13911, Q14049, Q16259, Q16597, Q9UML3	Gene names	COL6A2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

GOGA3_MOUSE
θ value	3.0926 (rank : 110)	NC score	-0.000502 (rank : 135)
Query Neighborhood Hits	123	Target Neighborhood Hits	1437	Shared Neighborhood Hits	8
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

TFE2_MOUSE
θ value	3.0926 (rank : 111)	NC score	0.153851 (rank : 95)
Query Neighborhood Hits	123	Target Neighborhood Hits	118	Shared Neighborhood Hits	48
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

RNZ2_MOUSE
θ value	4.03905 (rank : 112)	NC score	0.015989 (rank : 123)
Query Neighborhood Hits	123	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q80Y81, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2	Gene names	Elac2
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (Ribonuclease Z 2) (RNase Z 2) (tRNase Z 2) (tRNA 3 endonuclease 2) (ElaC homolog protein 2).

ID3_MOUSE
θ value	5.27518 (rank : 113)	NC score	0.150665 (rank : 96)
Query Neighborhood Hits	123	Target Neighborhood Hits	35	Shared Neighborhood Hits	34
SwissProt Accessions	P41133	Gene names	Id3, Hlh462, Id-3, Idb3
Domain Architecture
Description	DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID- like protein inhibitor HLH 462).

CO6A2_MOUSE
θ value	6.88961 (rank : 114)	NC score	0.009892 (rank : 129)
Query Neighborhood Hits	123	Target Neighborhood Hits	260	Shared Neighborhood Hits	8
SwissProt Accessions	Q02788, Q05505	Gene names	Col6a2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

MYCL2_HUMAN
θ value	6.88961 (rank : 115)	NC score	0.135029 (rank : 98)
Query Neighborhood Hits	123	Target Neighborhood Hits	63	Shared Neighborhood Hits	25
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

PAK4_MOUSE
θ value	6.88961 (rank : 116)	NC score	-0.005232 (rank : 136)
Query Neighborhood Hits	123	Target Neighborhood Hits	1098	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

UBP42_HUMAN
θ value	6.88961 (rank : 117)	NC score	0.005544 (rank : 130)
Query Neighborhood Hits	123	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

ASTL_HUMAN
θ value	8.99809 (rank : 118)	NC score	0.005137 (rank : 131)
Query Neighborhood Hits	123	Target Neighborhood Hits	252	Shared Neighborhood Hits	3
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

CTDP1_HUMAN
θ value	8.99809 (rank : 119)	NC score	0.011794 (rank : 127)
Query Neighborhood Hits	123	Target Neighborhood Hits	416	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

HEY1_HUMAN
θ value	8.99809 (rank : 120)	NC score	0.052525 (rank : 115)
Query Neighborhood Hits	123	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	8.99809 (rank : 121)	NC score	0.051398 (rank : 116)
Query Neighborhood Hits	123	Target Neighborhood Hits	69	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

SDK1_HUMAN
θ value	8.99809 (rank : 122)	NC score	-0.000078 (rank : 133)
Query Neighborhood Hits	123	Target Neighborhood Hits	511	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

TARA_MOUSE
θ value	8.99809 (rank : 123)	NC score	0.003266 (rank : 132)
Query Neighborhood Hits	123	Target Neighborhood Hits	1133	Shared Neighborhood Hits	14
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

HES3_MOUSE
θ value	θ > 10 (rank : 124)	NC score	0.053201 (rank : 114)
Query Neighborhood Hits	123	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

ID3_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.136677 (rank : 97)
Query Neighborhood Hits	123	Target Neighborhood Hits	33	Shared Neighborhood Hits	32
SwissProt Accessions	Q02535, O75641	Gene names	ID3, 1R21, HEIR-1
Domain Architecture
Description	DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID- like protein inhibitor HLH 1R21) (Helix-loop-helix protein HEIR-1).

MAD1_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.065051 (rank : 107)
Query Neighborhood Hits	123	Target Neighborhood Hits	75	Shared Neighborhood Hits	24
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MAD3_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.058843 (rank : 111)
Query Neighborhood Hits	123	Target Neighborhood Hits	94	Shared Neighborhood Hits	20
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MITF_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.050542 (rank : 117)
Query Neighborhood Hits	123	Target Neighborhood Hits	113	Shared Neighborhood Hits	31
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MLX_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.077450 (rank : 104)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 130)	NC score	0.080252 (rank : 103)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MXI1_HUMAN
θ value	θ > 10 (rank : 131)	NC score	0.060822 (rank : 110)
Query Neighborhood Hits	123	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	θ > 10 (rank : 132)	NC score	0.062154 (rank : 109)
Query Neighborhood Hits	123	Target Neighborhood Hits	109	Shared Neighborhood Hits	23
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYCB_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.093328 (rank : 101)
Query Neighborhood Hits	123	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

SRBP1_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.063299 (rank : 108)
Query Neighborhood Hits	123	Target Neighborhood Hits	225	Shared Neighborhood Hits	44
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.058281 (rank : 112)
Query Neighborhood Hits	123	Target Neighborhood Hits	384	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.065745 (rank : 106)
Query Neighborhood Hits	123	Target Neighborhood Hits	133	Shared Neighborhood Hits	32
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

Hits sorted by NC score

BHLH8_HUMAN
NC score	0.999962 (rank : 1)	θ value	8.22888e-78 (rank : 1)
Query Neighborhood Hits	123	Target Neighborhood Hits	123	Shared Neighborhood Hits	123
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
NC score	0.992662 (rank : 2)	θ value	9.45883e-58 (rank : 2)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	104
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

NGN2_MOUSE
NC score	0.869262 (rank : 3)	θ value	2.0648e-12 (rank : 3)
Query Neighborhood Hits	123	Target Neighborhood Hits	106	Shared Neighborhood Hits	77
SwissProt Accessions	P70447, P70237	Gene names	Neurog2, Ath4a, Atoh4, Ngn2
Domain Architecture
Description	Neurogenin 2 (Atonal protein homolog 4) (Helix-loop-helix protein mATH-4A) (MATH4A).

NGN2_HUMAN
NC score	0.867001 (rank : 4)	θ value	5.08577e-11 (rank : 7)
Query Neighborhood Hits	123	Target Neighborhood Hits	92	Shared Neighborhood Hits	77
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

NGN3_HUMAN
NC score	0.864161 (rank : 5)	θ value	3.89403e-11 (rank : 6)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y4Z2, Q9BY24	Gene names	NEUROG3, NGN3
Domain Architecture
Description	Neurogenin 3.

NGN3_MOUSE
NC score	0.861977 (rank : 6)	θ value	2.52405e-10 (rank : 10)
Query Neighborhood Hits	123	Target Neighborhood Hits	90	Shared Neighborhood Hits	84
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

NGN1_HUMAN
NC score	0.857721 (rank : 7)	θ value	1.9326e-10 (rank : 8)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	77
SwissProt Accessions	Q92886, Q96HE1	Gene names	NEUROG1, NEUROD3, NGN, NGN1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein).

NGN1_MOUSE
NC score	0.855564 (rank : 8)	θ value	1.9326e-10 (rank : 9)
Query Neighborhood Hits	123	Target Neighborhood Hits	87	Shared Neighborhood Hits	77
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

SCX_MOUSE
NC score	0.844503 (rank : 9)	θ value	6.87365e-08 (rank : 27)
Query Neighborhood Hits	123	Target Neighborhood Hits	82	Shared Neighborhood Hits	82
SwissProt Accessions	Q64124	Gene names	Scx
Domain Architecture
Description	Basic helix-loop-helix transcription factor scleraxis.

PTF1A_HUMAN
NC score	0.815151 (rank : 10)	θ value	1.99992e-07 (rank : 36)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	91
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

ATOH1_HUMAN
NC score	0.809856 (rank : 11)	θ value	1.02475e-11 (rank : 4)
Query Neighborhood Hits	123	Target Neighborhood Hits	97	Shared Neighborhood Hits	81
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

PTF1A_MOUSE
NC score	0.808447 (rank : 12)	θ value	6.87365e-08 (rank : 26)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	91
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

TCF15_MOUSE
NC score	0.806113 (rank : 13)	θ value	6.87365e-08 (rank : 28)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	76
SwissProt Accessions	Q60756, Q60788	Gene names	Tcf15, Bhlhec2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis) (Meso1).

ATOH1_MOUSE
NC score	0.805285 (rank : 14)	θ value	3.89403e-11 (rank : 5)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	83
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

TWST1_MOUSE
NC score	0.804523 (rank : 15)	θ value	1.29631e-06 (rank : 45)
Query Neighborhood Hits	123	Target Neighborhood Hits	101	Shared Neighborhood Hits	93
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

TWST1_HUMAN
NC score	0.804479 (rank : 16)	θ value	1.29631e-06 (rank : 44)
Query Neighborhood Hits	123	Target Neighborhood Hits	93	Shared Neighborhood Hits	91
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST2_MOUSE
NC score	0.803792 (rank : 17)	θ value	1.17247e-07 (rank : 34)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	91
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_HUMAN
NC score	0.803548 (rank : 18)	θ value	1.17247e-07 (rank : 33)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	91
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TCF15_HUMAN
NC score	0.797643 (rank : 19)	θ value	8.97725e-08 (rank : 30)
Query Neighborhood Hits	123	Target Neighborhood Hits	79	Shared Neighborhood Hits	73
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

HAND2_HUMAN
NC score	0.791729 (rank : 20)	θ value	4.0297e-08 (rank : 24)
Query Neighborhood Hits	123	Target Neighborhood Hits	99	Shared Neighborhood Hits	93
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
NC score	0.791729 (rank : 21)	θ value	4.0297e-08 (rank : 25)
Query Neighborhood Hits	123	Target Neighborhood Hits	99	Shared Neighborhood Hits	93
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

TAL2_MOUSE
NC score	0.788339 (rank : 22)	θ value	9.92553e-07 (rank : 39)
Query Neighborhood Hits	123	Target Neighborhood Hits	79	Shared Neighborhood Hits	78
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

NDF2_HUMAN
NC score	0.788019 (rank : 23)	θ value	3.64472e-09 (rank : 15)
Query Neighborhood Hits	123	Target Neighborhood Hits	113	Shared Neighborhood Hits	85
SwissProt Accessions	Q15784, Q8TBI7, Q9UQC6	Gene names	NEUROD2, NDRF
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF2_MOUSE
NC score	0.788000 (rank : 24)	θ value	3.64472e-09 (rank : 16)
Query Neighborhood Hits	123	Target Neighborhood Hits	111	Shared Neighborhood Hits	85
SwissProt Accessions	Q62414, Q61952, Q925V5	Gene names	Neurod2, Ndrf
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

TAL2_HUMAN
NC score	0.786776 (rank : 25)	θ value	3.77169e-06 (rank : 46)
Query Neighborhood Hits	123	Target Neighborhood Hits	77	Shared Neighborhood Hits	75
SwissProt Accessions	Q16559	Gene names	TAL2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein (TAL-2 protein).

NDF4_HUMAN
NC score	0.779283 (rank : 26)	θ value	6.21693e-09 (rank : 18)
Query Neighborhood Hits	123	Target Neighborhood Hits	91	Shared Neighborhood Hits	83
SwissProt Accessions	Q9HD90	Gene names	NEUROD4
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4).

NDF4_MOUSE
NC score	0.777905 (rank : 27)	θ value	3.64472e-09 (rank : 17)
Query Neighborhood Hits	123	Target Neighborhood Hits	105	Shared Neighborhood Hits	83
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

LYL1_HUMAN
NC score	0.770526 (rank : 28)	θ value	3.41135e-07 (rank : 38)
Query Neighborhood Hits	123	Target Neighborhood Hits	113	Shared Neighborhood Hits	90
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

NDF1_HUMAN
NC score	0.767829 (rank : 29)	θ value	2.79066e-09 (rank : 13)
Query Neighborhood Hits	123	Target Neighborhood Hits	186	Shared Neighborhood Hits	78
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

LYL1_MOUSE
NC score	0.766212 (rank : 30)	θ value	8.97725e-08 (rank : 29)
Query Neighborhood Hits	123	Target Neighborhood Hits	102	Shared Neighborhood Hits	90
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

NDF1_MOUSE
NC score	0.763250 (rank : 31)	θ value	2.79066e-09 (rank : 14)
Query Neighborhood Hits	123	Target Neighborhood Hits	209	Shared Neighborhood Hits	78
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

BHLH4_HUMAN
NC score	0.759657 (rank : 32)	θ value	1.17247e-07 (rank : 31)
Query Neighborhood Hits	123	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	Q8NDY6	Gene names	BHLHB4
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

ASCL2_HUMAN
NC score	0.756153 (rank : 33)	θ value	2.61198e-07 (rank : 37)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	84
SwissProt Accessions	Q99929, Q9UM68	Gene names	ASCL2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash2) (HASH2).

BHLH4_MOUSE
NC score	0.750535 (rank : 34)	θ value	1.17247e-07 (rank : 32)
Query Neighborhood Hits	123	Target Neighborhood Hits	71	Shared Neighborhood Hits	63
SwissProt Accessions	Q8BGW3, Q71MB7	Gene names	Bhlhb4, H20
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

HAND1_HUMAN
NC score	0.750054 (rank : 35)	θ value	1.29631e-06 (rank : 40)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	89
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HAND1_MOUSE
NC score	0.747531 (rank : 36)	θ value	1.29631e-06 (rank : 41)
Query Neighborhood Hits	123	Target Neighborhood Hits	107	Shared Neighborhood Hits	91
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

HEN1_HUMAN
NC score	0.743206 (rank : 37)	θ value	0.00102713 (rank : 56)
Query Neighborhood Hits	123	Target Neighborhood Hits	88	Shared Neighborhood Hits	75
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

TAL1_MOUSE
NC score	0.738693 (rank : 38)	θ value	1.29631e-06 (rank : 43)
Query Neighborhood Hits	123	Target Neighborhood Hits	110	Shared Neighborhood Hits	89
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

NDF6_MOUSE
NC score	0.738122 (rank : 39)	θ value	1.25267e-09 (rank : 12)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	74
SwissProt Accessions	P48986	Gene names	Neurod6, Ath2, Atoh2, Nex1
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6) (Atonal protein homolog 2) (Helix-loop-helix protein mATH-2) (MATH2) (NEX-1 protein).

NDF6_HUMAN
NC score	0.738015 (rank : 40)	θ value	1.25267e-09 (rank : 11)
Query Neighborhood Hits	123	Target Neighborhood Hits	91	Shared Neighborhood Hits	74
SwissProt Accessions	Q96NK8, Q9H3H6	Gene names	NEUROD6
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6).

TAL1_HUMAN
NC score	0.737632 (rank : 41)	θ value	1.29631e-06 (rank : 42)
Query Neighborhood Hits	123	Target Neighborhood Hits	112	Shared Neighborhood Hits	89
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

HEN1_MOUSE
NC score	0.736271 (rank : 42)	θ value	0.00102713 (rank : 57)
Query Neighborhood Hits	123	Target Neighborhood Hits	86	Shared Neighborhood Hits	75
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

ASCL2_MOUSE
NC score	0.734443 (rank : 43)	θ value	1.99992e-07 (rank : 35)
Query Neighborhood Hits	123	Target Neighborhood Hits	98	Shared Neighborhood Hits	85
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

OLIG2_MOUSE
NC score	0.731667 (rank : 44)	θ value	1.38499e-08 (rank : 22)
Query Neighborhood Hits	123	Target Neighborhood Hits	74	Shared Neighborhood Hits	62
SwissProt Accessions	Q9EQW6, Q9JKN4	Gene names	Olig2
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2).

OLIG2_HUMAN
NC score	0.728984 (rank : 45)	θ value	1.38499e-08 (rank : 21)
Query Neighborhood Hits	123	Target Neighborhood Hits	84	Shared Neighborhood Hits	64
SwissProt Accessions	Q13516, Q86X04, Q9NZ14	Gene names	OLIG2, BHLHB1, PRKCBP2, RACK17
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2) (Basic helix-loop- helix protein class B 1) (Protein kinase C-binding protein RACK17) (Protein kinase C-binding protein 2).

OLIG3_MOUSE
NC score	0.728191 (rank : 46)	θ value	6.21693e-09 (rank : 20)
Query Neighborhood Hits	123	Target Neighborhood Hits	76	Shared Neighborhood Hits	59
SwissProt Accessions	Q6PFG8, Q9EQW5	Gene names	Olig3, Bhlhb7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Oligodendrocyte- specific bHLH transcription factor 3) (Basic helix-loop-helix domain- containing class B protein 7).

MUSC_MOUSE
NC score	0.726137 (rank : 47)	θ value	3.19293e-05 (rank : 53)
Query Neighborhood Hits	123	Target Neighborhood Hits	78	Shared Neighborhood Hits	71
SwissProt Accessions	O88940	Gene names	Msc, Myor
Domain Architecture
Description	Musculin (Myogenic repressor).

OLIG3_HUMAN
NC score	0.722455 (rank : 48)	θ value	6.21693e-09 (rank : 19)
Query Neighborhood Hits	123	Target Neighborhood Hits	77	Shared Neighborhood Hits	59
SwissProt Accessions	Q7RTU3, Q8N8Q0	Gene names	OLIG3, BHLHB7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Basic helix-loop- helix domain-containing class B protein 7).

HEN2_HUMAN
NC score	0.717977 (rank : 49)	θ value	0.00102713 (rank : 58)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	76
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

MUSC_HUMAN
NC score	0.715332 (rank : 50)	θ value	3.19293e-05 (rank : 52)
Query Neighborhood Hits	123	Target Neighborhood Hits	78	Shared Neighborhood Hits	71
SwissProt Accessions	O60682, O75946, Q9BRE7	Gene names	MSC, ABF1
Domain Architecture
Description	Musculin (Activated B-cell factor 1) (ABF-1).

HEN2_MOUSE
NC score	0.715096 (rank : 51)	θ value	0.00102713 (rank : 59)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	76
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

FIGLA_HUMAN
NC score	0.711107 (rank : 52)	θ value	0.00228821 (rank : 60)
Query Neighborhood Hits	123	Target Neighborhood Hits	108	Shared Neighborhood Hits	94
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

OLIG1_HUMAN
NC score	0.708481 (rank : 53)	θ value	6.43352e-06 (rank : 47)
Query Neighborhood Hits	123	Target Neighborhood Hits	85	Shared Neighborhood Hits	66
SwissProt Accessions	Q8TAK6, Q7RTS0	Gene names	OLIG1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1).

TCF21_HUMAN
NC score	0.708222 (rank : 54)	θ value	1.87187e-05 (rank : 50)
Query Neighborhood Hits	123	Target Neighborhood Hits	68	Shared Neighborhood Hits	67
SwissProt Accessions	O43680, O43545, Q9BZ14	Gene names	TCF21, POD1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

FIGLA_MOUSE
NC score	0.704445 (rank : 55)	θ value	0.00298849 (rank : 61)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	93
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

TCF21_MOUSE
NC score	0.704355 (rank : 56)	θ value	1.87187e-05 (rank : 51)
Query Neighborhood Hits	123	Target Neighborhood Hits	69	Shared Neighborhood Hits	67
SwissProt Accessions	O35437, Q3U023	Gene names	Tcf21, Pod1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

OLIG1_MOUSE
NC score	0.700671 (rank : 57)	θ value	3.08544e-08 (rank : 23)
Query Neighborhood Hits	123	Target Neighborhood Hits	69	Shared Neighborhood Hits	60
SwissProt Accessions	Q9JKN5	Gene names	Olig1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1) (Oligodendrocyte- specific bHLH transcription factor 1).

ASCL1_MOUSE
NC score	0.695328 (rank : 58)	θ value	1.09739e-05 (rank : 49)
Query Neighborhood Hits	123	Target Neighborhood Hits	97	Shared Neighborhood Hits	87
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

ASCL1_HUMAN
NC score	0.693544 (rank : 59)	θ value	1.09739e-05 (rank : 48)
Query Neighborhood Hits	123	Target Neighborhood Hits	94	Shared Neighborhood Hits	87
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

ASCL3_MOUSE
NC score	0.656755 (rank : 60)	θ value	0.000461057 (rank : 55)
Query Neighborhood Hits	123	Target Neighborhood Hits	70	Shared Neighborhood Hits	68
SwissProt Accessions	Q9JJR7	Gene names	Ascl3, Mash3, Sgn1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1) (Mash- 3).

ASCL3_HUMAN
NC score	0.643978 (rank : 61)	θ value	0.000270298 (rank : 54)
Query Neighborhood Hits	123	Target Neighborhood Hits	70	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NQ33, Q8WYQ6	Gene names	ASCL3, HASH3, SGN1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1).

TFAP4_HUMAN
NC score	0.476784 (rank : 62)	θ value	0.00390308 (rank : 64)
Query Neighborhood Hits	123	Target Neighborhood Hits	289	Shared Neighborhood Hits	75
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

MYF5_MOUSE
NC score	0.444171 (rank : 63)	θ value	0.0431538 (rank : 73)
Query Neighborhood Hits	123	Target Neighborhood Hits	77	Shared Neighborhood Hits	69
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYF5_HUMAN
NC score	0.436196 (rank : 64)	θ value	0.0431538 (rank : 72)
Query Neighborhood Hits	123	Target Neighborhood Hits	80	Shared Neighborhood Hits	69
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYOD1_MOUSE
NC score	0.398718 (rank : 65)	θ value	0.0431538 (rank : 75)
Query Neighborhood Hits	123	Target Neighborhood Hits	82	Shared Neighborhood Hits	64
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

MYOD1_HUMAN
NC score	0.396835 (rank : 66)	θ value	0.0431538 (rank : 74)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	66
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYF6_HUMAN
NC score	0.388323 (rank : 67)	θ value	0.163984 (rank : 84)
Query Neighborhood Hits	123	Target Neighborhood Hits	74	Shared Neighborhood Hits	60
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
NC score	0.386087 (rank : 68)	θ value	0.163984 (rank : 85)
Query Neighborhood Hits	123	Target Neighborhood Hits	72	Shared Neighborhood Hits	59
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

MYOG_HUMAN
NC score	0.350975 (rank : 69)	θ value	0.00390308 (rank : 62)
Query Neighborhood Hits	123	Target Neighborhood Hits	67	Shared Neighborhood Hits	55
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
NC score	0.348179 (rank : 70)	θ value	0.00390308 (rank : 63)
Query Neighborhood Hits	123	Target Neighborhood Hits	71	Shared Neighborhood Hits	55
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

ID4_HUMAN
NC score	0.309717 (rank : 71)	θ value	2.36792 (rank : 104)
Query Neighborhood Hits	123	Target Neighborhood Hits	67	Shared Neighborhood Hits	65
SwissProt Accessions	P47928, Q13005	Gene names	ID4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID1_HUMAN
NC score	0.306545 (rank : 72)	θ value	0.163984 (rank : 81)
Query Neighborhood Hits	123	Target Neighborhood Hits	63	Shared Neighborhood Hits	59
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

ID4_MOUSE
NC score	0.304412 (rank : 73)	θ value	2.36792 (rank : 105)
Query Neighborhood Hits	123	Target Neighborhood Hits	66	Shared Neighborhood Hits	65
SwissProt Accessions	P41139	Gene names	Id4, Id-4, Idb4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID1_MOUSE
NC score	0.280283 (rank : 74)	θ value	1.38821 (rank : 99)
Query Neighborhood Hits	123	Target Neighborhood Hits	64	Shared Neighborhood Hits	59
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

MYC_MOUSE
NC score	0.260937 (rank : 75)	θ value	0.0113563 (rank : 67)
Query Neighborhood Hits	123	Target Neighborhood Hits	125	Shared Neighborhood Hits	49
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCS_MOUSE
NC score	0.260915 (rank : 76)	θ value	0.00665767 (rank : 65)
Query Neighborhood Hits	123	Target Neighborhood Hits	83	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYCN_MOUSE
NC score	0.246360 (rank : 77)	θ value	0.0252991 (rank : 70)
Query Neighborhood Hits	123	Target Neighborhood Hits	125	Shared Neighborhood Hits	45
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_HUMAN
NC score	0.245535 (rank : 78)	θ value	0.0252991 (rank : 71)
Query Neighborhood Hits	123	Target Neighborhood Hits	146	Shared Neighborhood Hits	49
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCN_HUMAN
NC score	0.241005 (rank : 79)	θ value	0.0113563 (rank : 66)
Query Neighborhood Hits	123	Target Neighborhood Hits	127	Shared Neighborhood Hits	46
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

ID2_HUMAN
NC score	0.237671 (rank : 80)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	123	Target Neighborhood Hits	48	Shared Neighborhood Hits	47
SwissProt Accessions	Q02363	Gene names	ID2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

MAX_MOUSE
NC score	0.217363 (rank : 81)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	123	Target Neighborhood Hits	139	Shared Neighborhood Hits	44
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

ID2_MOUSE
NC score	0.217112 (rank : 82)	θ value	2.36792 (rank : 103)
Query Neighborhood Hits	123	Target Neighborhood Hits	47	Shared Neighborhood Hits	46
SwissProt Accessions	P41136, O88604	Gene names	Id2, Id-2, Idb2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

MAX_HUMAN
NC score	0.214991 (rank : 83)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	123	Target Neighborhood Hits	125	Shared Neighborhood Hits	42
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MYCL1_HUMAN
NC score	0.193609 (rank : 84)	θ value	0.163984 (rank : 82)
Query Neighborhood Hits	123	Target Neighborhood Hits	146	Shared Neighborhood Hits	45
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MNT_MOUSE
NC score	0.192750 (rank : 85)	θ value	0.0961366 (rank : 80)
Query Neighborhood Hits	123	Target Neighborhood Hits	432	Shared Neighborhood Hits	55
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

ITF2_MOUSE
NC score	0.190999 (rank : 86)	θ value	0.0736092 (rank : 78)
Query Neighborhood Hits	123	Target Neighborhood Hits	154	Shared Neighborhood Hits	51
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

ITF2_HUMAN
NC score	0.190246 (rank : 87)	θ value	0.0736092 (rank : 77)
Query Neighborhood Hits	123	Target Neighborhood Hits	168	Shared Neighborhood Hits	51
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

MYCL1_MOUSE
NC score	0.189271 (rank : 88)	θ value	0.163984 (rank : 83)
Query Neighborhood Hits	123	Target Neighborhood Hits	123	Shared Neighborhood Hits	40
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MNT_HUMAN
NC score	0.181248 (rank : 89)	θ value	0.0961366 (rank : 79)
Query Neighborhood Hits	123	Target Neighborhood Hits	496	Shared Neighborhood Hits	50
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

HTF4_MOUSE
NC score	0.171797 (rank : 90)	θ value	1.06291 (rank : 94)
Query Neighborhood Hits	123	Target Neighborhood Hits	153	Shared Neighborhood Hits	54
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

HTF4_HUMAN
NC score	0.166039 (rank : 91)	θ value	1.06291 (rank : 93)
Query Neighborhood Hits	123	Target Neighborhood Hits	152	Shared Neighborhood Hits	52
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

TFE2_HUMAN
NC score	0.157835 (rank : 92)	θ value	2.36792 (rank : 107)
Query Neighborhood Hits	123	Target Neighborhood Hits	161	Shared Neighborhood Hits	47
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

USF2_MOUSE
NC score	0.157350 (rank : 93)	θ value	0.0148317 (rank : 69)
Query Neighborhood Hits	123	Target Neighborhood Hits	173	Shared Neighborhood Hits	31
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
NC score	0.157255 (rank : 94)	θ value	0.0148317 (rank : 68)
Query Neighborhood Hits	123	Target Neighborhood Hits	155	Shared Neighborhood Hits	31
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

TFE2_MOUSE
NC score	0.153851 (rank : 95)	θ value	3.0926 (rank : 111)
Query Neighborhood Hits	123	Target Neighborhood Hits	118	Shared Neighborhood Hits	48
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

ID3_MOUSE
NC score	0.150665 (rank : 96)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	123	Target Neighborhood Hits	35	Shared Neighborhood Hits	34
SwissProt Accessions	P41133	Gene names	Id3, Hlh462, Id-3, Idb3
Domain Architecture
Description	DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID- like protein inhibitor HLH 462).

ID3_HUMAN
NC score	0.136677 (rank : 97)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	123	Target Neighborhood Hits	33	Shared Neighborhood Hits	32
SwissProt Accessions	Q02535, O75641	Gene names	ID3, 1R21, HEIR-1
Domain Architecture
Description	DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID- like protein inhibitor HLH 1R21) (Helix-loop-helix protein HEIR-1).

MYCL2_HUMAN
NC score	0.135029 (rank : 98)	θ value	6.88961 (rank : 115)
Query Neighborhood Hits	123	Target Neighborhood Hits	63	Shared Neighborhood Hits	25
SwissProt Accessions	P12525	Gene names	MYCL2
Domain Architecture
Description	L-myc-2 protein.

USF1_HUMAN
NC score	0.121108 (rank : 99)	θ value	0.47712 (rank : 89)
Query Neighborhood Hits	123	Target Neighborhood Hits	70	Shared Neighborhood Hits	24
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.119114 (rank : 100)	θ value	1.38821 (rank : 102)
Query Neighborhood Hits	123	Target Neighborhood Hits	71	Shared Neighborhood Hits	24
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MYCB_MOUSE
NC score	0.093328 (rank : 101)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	123	Target Neighborhood Hits	14	Shared Neighborhood Hits	8
SwissProt Accessions	Q6P8Z1, Q9D6E3	Gene names	Mycb, Bmyc
Domain Architecture	No domain graphic available
Description	Protein B-Myc.

HEY2_MOUSE
NC score	0.083304 (rank : 102)	θ value	1.38821 (rank : 98)
Query Neighborhood Hits	123	Target Neighborhood Hits	80	Shared Neighborhood Hits	31
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MLX_MOUSE
NC score	0.080252 (rank : 103)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	123	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.077450 (rank : 104)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	123	Target Neighborhood Hits	95	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

HEY2_HUMAN
NC score	0.077053 (rank : 105)	θ value	1.38821 (rank : 97)
Query Neighborhood Hits	123	Target Neighborhood Hits	77	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

SRBP2_HUMAN
NC score	0.065745 (rank : 106)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	123	Target Neighborhood Hits	133	Shared Neighborhood Hits	32
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

MAD1_MOUSE
NC score	0.065051 (rank : 107)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	123	Target Neighborhood Hits	75	Shared Neighborhood Hits	24
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SRBP1_HUMAN
NC score	0.063299 (rank : 108)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	123	Target Neighborhood Hits	225	Shared Neighborhood Hits	44
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MXI1_MOUSE
NC score	0.062154 (rank : 109)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	123	Target Neighborhood Hits	109	Shared Neighborhood Hits	23
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_HUMAN
NC score	0.060822 (rank : 110)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	123	Target Neighborhood Hits	76	Shared Neighborhood Hits	23
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD3_MOUSE
NC score	0.058843 (rank : 111)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	123	Target Neighborhood Hits	94	Shared Neighborhood Hits	20
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

SRBP1_MOUSE
NC score	0.058281 (rank : 112)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	123	Target Neighborhood Hits	384	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAD3_HUMAN
NC score	0.057991 (rank : 113)	θ value	2.36792 (rank : 106)
Query Neighborhood Hits	123	Target Neighborhood Hits	92	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

HES3_MOUSE
NC score	0.053201 (rank : 114)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	123	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HEY1_HUMAN
NC score	0.052525 (rank : 115)	θ value	8.99809 (rank : 120)
Query Neighborhood Hits	123	Target Neighborhood Hits	82	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
NC score	0.051398 (rank : 116)	θ value	8.99809 (rank : 121)
Query Neighborhood Hits	123	Target Neighborhood Hits	69	Shared Neighborhood Hits	22
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

MITF_HUMAN
NC score	0.050542 (rank : 117)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	123	Target Neighborhood Hits	113	Shared Neighborhood Hits	31
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

CGRE1_HUMAN
NC score	0.032439 (rank : 118)	θ value	0.62314 (rank : 90)
Query Neighborhood Hits	123	Target Neighborhood Hits	354	Shared Neighborhood Hits	10
SwissProt Accessions	Q99674	Gene names	CGREF1, CGR11
Domain Architecture	No domain graphic available
Description	Cell growth regulator with EF hand domain 1 (Cell growth regulatory gene 11 protein).

PRRT3_HUMAN
NC score	0.026597 (rank : 119)	θ value	0.279714 (rank : 87)
Query Neighborhood Hits	123	Target Neighborhood Hits	998	Shared Neighborhood Hits	17
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

CT151_HUMAN
NC score	0.026167 (rank : 120)	θ value	1.38821 (rank : 96)
Query Neighborhood Hits	123	Target Neighborhood Hits	382	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

OGFR_HUMAN
NC score	0.022143 (rank : 121)	θ value	0.0431538 (rank : 76)
Query Neighborhood Hits	123	Target Neighborhood Hits	1582	Shared Neighborhood Hits	20
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

S39A5_MOUSE
NC score	0.021234 (rank : 122)	θ value	1.38821 (rank : 101)
Query Neighborhood Hits	123	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D856, Q9D909	Gene names	Slc39a5, Zip5
Domain Architecture	No domain graphic available
Description	Zinc transporter ZIP5 precursor (Solute carrier family 39 member 5).

RNZ2_MOUSE
NC score	0.015989 (rank : 123)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	123	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q80Y81, Q99MF0, Q99MF1, Q9CTA2, Q9D1A8, Q9EPZ2	Gene names	Elac2
Domain Architecture
Description	Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (Ribonuclease Z 2) (RNase Z 2) (tRNase Z 2) (tRNA 3 endonuclease 2) (ElaC homolog protein 2).

NTBP1_MOUSE
NC score	0.015712 (rank : 124)	θ value	1.38821 (rank : 100)
Query Neighborhood Hits	123	Target Neighborhood Hits	528	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

IASPP_MOUSE
NC score	0.013759 (rank : 125)	θ value	0.279714 (rank : 86)
Query Neighborhood Hits	123	Target Neighborhood Hits	1024	Shared Neighborhood Hits	11
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CO6A2_HUMAN
NC score	0.011807 (rank : 126)	θ value	3.0926 (rank : 109)
Query Neighborhood Hits	123	Target Neighborhood Hits	249	Shared Neighborhood Hits	8
SwissProt Accessions	P12110, Q13909, Q13910, Q13911, Q14049, Q16259, Q16597, Q9UML3	Gene names	COL6A2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

CTDP1_HUMAN
NC score	0.011794 (rank : 127)	θ value	8.99809 (rank : 119)
Query Neighborhood Hits	123	Target Neighborhood Hits	416	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

AIRE_MOUSE
NC score	0.010350 (rank : 128)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	123	Target Neighborhood Hits	196	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0E3, Q9JLW0, Q9JLW1, Q9JLW2, Q9JLW3, Q9JLW4, Q9JLW5, Q9JLW6, Q9JLW7, Q9JLW8, Q9JLW9, Q9JLX0	Gene names	Aire
Domain Architecture
Description	Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog).

CO6A2_MOUSE
NC score	0.009892 (rank : 129)	θ value	6.88961 (rank : 114)
Query Neighborhood Hits	123	Target Neighborhood Hits	260	Shared Neighborhood Hits	8
SwissProt Accessions	Q02788, Q05505	Gene names	Col6a2
Domain Architecture
Description	Collagen alpha-2(VI) chain precursor.

UBP42_HUMAN
NC score	0.005544 (rank : 130)	θ value	6.88961 (rank : 117)
Query Neighborhood Hits	123	Target Neighborhood Hits	445	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H9J4, Q3C166, Q6P9B4	Gene names	USP42
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 42 (EC 3.1.2.15) (Ubiquitin thioesterase 42) (Ubiquitin-specific-processing protease 42) (Deubiquitinating enzyme 42).

ASTL_HUMAN
NC score	0.005137 (rank : 131)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	123	Target Neighborhood Hits	252	Shared Neighborhood Hits	3
SwissProt Accessions	Q6HA08	Gene names	ASTL
Domain Architecture	No domain graphic available
Description	Astacin-like metalloendopeptidase precursor (EC 3.4.-.-) (Oocyte astacin) (Ovastacin).

TARA_MOUSE
NC score	0.003266 (rank : 132)	θ value	8.99809 (rank : 123)
Query Neighborhood Hits	123	Target Neighborhood Hits	1133	Shared Neighborhood Hits	14
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SDK1_HUMAN
NC score	-0.000078 (rank : 133)	θ value	8.99809 (rank : 122)
Query Neighborhood Hits	123	Target Neighborhood Hits	511	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z5N4, Q8TEN9, Q8TEP5, Q96N44	Gene names	SDK1
Domain Architecture	No domain graphic available
Description	Protein sidekick-1 precursor.

SPEG_HUMAN
NC score	-0.000327 (rank : 134)	θ value	0.279714 (rank : 88)
Query Neighborhood Hits	123	Target Neighborhood Hits	1762	Shared Neighborhood Hits	15
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

GOGA3_MOUSE
NC score	-0.000502 (rank : 135)	θ value	3.0926 (rank : 110)
Query Neighborhood Hits	123	Target Neighborhood Hits	1437	Shared Neighborhood Hits	8
SwissProt Accessions	P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3	Gene names	Golga3, Mea2
Domain Architecture
Description	Golgin subfamily A member 3 (Golgin-160) (Male-enhanced antigen 2) (MEA-2).

PAK4_MOUSE
NC score	-0.005232 (rank : 136)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	123	Target Neighborhood Hits	1098	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BTW9, Q6ZPX0, Q80Z97, Q9CS71	Gene names	Pak4, Kiaa1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).