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Network neighborhood for query Sequence : HEN1_MOUSE

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HEN1_MOUSE
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HEN1_MOUSE
θ value	3.74554e-30 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	86	Target Neighborhood Hits	86	Shared Neighborhood Hits	86
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_HUMAN
θ value	1.92365e-26 (rank : 2)	NC score	0.997021 (rank : 2)
Query Neighborhood Hits	86	Target Neighborhood Hits	88	Shared Neighborhood Hits	83
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN2_HUMAN
θ value	2.88119e-14 (rank : 3)	NC score	0.968549 (rank : 3)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	82
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HEN2_MOUSE
θ value	2.88119e-14 (rank : 4)	NC score	0.966880 (rank : 4)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	82
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

TAL1_HUMAN
θ value	9.59137e-10 (rank : 5)	NC score	0.848161 (rank : 9)
Query Neighborhood Hits	86	Target Neighborhood Hits	112	Shared Neighborhood Hits	79
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

TAL1_MOUSE
θ value	9.59137e-10 (rank : 6)	NC score	0.847967 (rank : 10)
Query Neighborhood Hits	86	Target Neighborhood Hits	110	Shared Neighborhood Hits	79
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

TAL2_MOUSE
θ value	9.59137e-10 (rank : 7)	NC score	0.903227 (rank : 6)
Query Neighborhood Hits	86	Target Neighborhood Hits	79	Shared Neighborhood Hits	70
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

TAL2_HUMAN
θ value	1.63604e-09 (rank : 8)	NC score	0.904614 (rank : 5)
Query Neighborhood Hits	86	Target Neighborhood Hits	77	Shared Neighborhood Hits	70
SwissProt Accessions	Q16559	Gene names	TAL2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein (TAL-2 protein).

LYL1_HUMAN
θ value	2.79066e-09 (rank : 9)	NC score	0.859344 (rank : 8)
Query Neighborhood Hits	86	Target Neighborhood Hits	113	Shared Neighborhood Hits	74
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

LYL1_MOUSE
θ value	2.79066e-09 (rank : 10)	NC score	0.844742 (rank : 11)
Query Neighborhood Hits	86	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

SCX_MOUSE
θ value	1.80886e-08 (rank : 11)	NC score	0.862194 (rank : 7)
Query Neighborhood Hits	86	Target Neighborhood Hits	82	Shared Neighborhood Hits	67
SwissProt Accessions	Q64124	Gene names	Scx
Domain Architecture
Description	Basic helix-loop-helix transcription factor scleraxis.

HAND1_MOUSE
θ value	3.08544e-08 (rank : 12)	NC score	0.824207 (rank : 17)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

HAND1_HUMAN
θ value	5.26297e-08 (rank : 13)	NC score	0.831180 (rank : 16)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HAND2_HUMAN
θ value	1.53129e-07 (rank : 14)	NC score	0.834034 (rank : 13)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	78
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
θ value	1.53129e-07 (rank : 15)	NC score	0.834034 (rank : 14)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	78
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

TWST2_HUMAN
θ value	2.61198e-07 (rank : 16)	NC score	0.803466 (rank : 21)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_MOUSE
θ value	2.61198e-07 (rank : 17)	NC score	0.803648 (rank : 20)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

PTF1A_HUMAN
θ value	4.45536e-07 (rank : 18)	NC score	0.785020 (rank : 22)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	74
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

PTF1A_MOUSE
θ value	4.45536e-07 (rank : 19)	NC score	0.778872 (rank : 23)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	74
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

TWST1_HUMAN
θ value	5.81887e-07 (rank : 20)	NC score	0.818310 (rank : 18)
Query Neighborhood Hits	86	Target Neighborhood Hits	93	Shared Neighborhood Hits	72
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
θ value	5.81887e-07 (rank : 21)	NC score	0.817809 (rank : 19)
Query Neighborhood Hits	86	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

TCF15_MOUSE
θ value	2.21117e-06 (rank : 22)	NC score	0.833772 (rank : 15)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	67
SwissProt Accessions	Q60756, Q60788	Gene names	Tcf15, Bhlhec2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis) (Meso1).

TCF15_HUMAN
θ value	4.92598e-06 (rank : 23)	NC score	0.837229 (rank : 12)
Query Neighborhood Hits	86	Target Neighborhood Hits	79	Shared Neighborhood Hits	66
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

NGN3_HUMAN
θ value	1.43324e-05 (rank : 24)	NC score	0.738401 (rank : 32)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y4Z2, Q9BY24	Gene names	NEUROG3, NGN3
Domain Architecture
Description	Neurogenin 3.

NGN3_MOUSE
θ value	1.43324e-05 (rank : 25)	NC score	0.742115 (rank : 31)
Query Neighborhood Hits	86	Target Neighborhood Hits	90	Shared Neighborhood Hits	68
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

NGN2_MOUSE
θ value	2.44474e-05 (rank : 26)	NC score	0.749085 (rank : 29)
Query Neighborhood Hits	86	Target Neighborhood Hits	106	Shared Neighborhood Hits	67
SwissProt Accessions	P70447, P70237	Gene names	Neurog2, Ath4a, Atoh4, Ngn2
Domain Architecture
Description	Neurogenin 2 (Atonal protein homolog 4) (Helix-loop-helix protein mATH-4A) (MATH4A).

NGN2_HUMAN
θ value	3.19293e-05 (rank : 27)	NC score	0.750264 (rank : 28)
Query Neighborhood Hits	86	Target Neighborhood Hits	92	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

ASCL3_MOUSE
θ value	4.1701e-05 (rank : 28)	NC score	0.725092 (rank : 36)
Query Neighborhood Hits	86	Target Neighborhood Hits	70	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JJR7	Gene names	Ascl3, Mash3, Sgn1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1) (Mash- 3).

NDF4_HUMAN
θ value	7.1131e-05 (rank : 29)	NC score	0.650688 (rank : 42)
Query Neighborhood Hits	86	Target Neighborhood Hits	91	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HD90	Gene names	NEUROD4
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4).

NDF4_MOUSE
θ value	7.1131e-05 (rank : 30)	NC score	0.650033 (rank : 44)
Query Neighborhood Hits	86	Target Neighborhood Hits	105	Shared Neighborhood Hits	71
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

ASCL3_HUMAN
θ value	9.29e-05 (rank : 31)	NC score	0.709259 (rank : 39)
Query Neighborhood Hits	86	Target Neighborhood Hits	70	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NQ33, Q8WYQ6	Gene names	ASCL3, HASH3, SGN1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1).

FIGLA_MOUSE
θ value	0.00020696 (rank : 32)	NC score	0.718389 (rank : 37)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

NDF1_HUMAN
θ value	0.000270298 (rank : 33)	NC score	0.627560 (rank : 49)
Query Neighborhood Hits	86	Target Neighborhood Hits	186	Shared Neighborhood Hits	68
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

NDF1_MOUSE
θ value	0.000270298 (rank : 34)	NC score	0.623069 (rank : 51)
Query Neighborhood Hits	86	Target Neighborhood Hits	209	Shared Neighborhood Hits	68
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

NDF2_HUMAN
θ value	0.000270298 (rank : 35)	NC score	0.639779 (rank : 47)
Query Neighborhood Hits	86	Target Neighborhood Hits	113	Shared Neighborhood Hits	71
SwissProt Accessions	Q15784, Q8TBI7, Q9UQC6	Gene names	NEUROD2, NDRF
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF2_MOUSE
θ value	0.000270298 (rank : 36)	NC score	0.639253 (rank : 48)
Query Neighborhood Hits	86	Target Neighborhood Hits	111	Shared Neighborhood Hits	71
SwissProt Accessions	Q62414, Q61952, Q925V5	Gene names	Neurod2, Ndrf
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

TCF21_HUMAN
θ value	0.000270298 (rank : 37)	NC score	0.758465 (rank : 24)
Query Neighborhood Hits	86	Target Neighborhood Hits	68	Shared Neighborhood Hits	65
SwissProt Accessions	O43680, O43545, Q9BZ14	Gene names	TCF21, POD1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

TCF21_MOUSE
θ value	0.000270298 (rank : 38)	NC score	0.755018 (rank : 26)
Query Neighborhood Hits	86	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	O35437, Q3U023	Gene names	Tcf21, Pod1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

FIGLA_HUMAN
θ value	0.00035302 (rank : 39)	NC score	0.713829 (rank : 38)
Query Neighborhood Hits	86	Target Neighborhood Hits	108	Shared Neighborhood Hits	77
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

NGN1_HUMAN
θ value	0.00035302 (rank : 40)	NC score	0.734645 (rank : 34)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	69
SwissProt Accessions	Q92886, Q96HE1	Gene names	NEUROG1, NEUROD3, NGN, NGN1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein).

NGN1_MOUSE
θ value	0.00035302 (rank : 41)	NC score	0.732566 (rank : 35)
Query Neighborhood Hits	86	Target Neighborhood Hits	87	Shared Neighborhood Hits	71
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

MUSC_HUMAN
θ value	0.000602161 (rank : 42)	NC score	0.752637 (rank : 27)
Query Neighborhood Hits	86	Target Neighborhood Hits	78	Shared Neighborhood Hits	69
SwissProt Accessions	O60682, O75946, Q9BRE7	Gene names	MSC, ABF1
Domain Architecture
Description	Musculin (Activated B-cell factor 1) (ABF-1).

MUSC_MOUSE
θ value	0.000602161 (rank : 43)	NC score	0.758416 (rank : 25)
Query Neighborhood Hits	86	Target Neighborhood Hits	78	Shared Neighborhood Hits	69
SwissProt Accessions	O88940	Gene names	Msc, Myor
Domain Architecture
Description	Musculin (Myogenic repressor).

BHLH8_HUMAN
θ value	0.00102713 (rank : 44)	NC score	0.736271 (rank : 33)
Query Neighborhood Hits	86	Target Neighborhood Hits	123	Shared Neighborhood Hits	75
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

BHLH8_MOUSE
θ value	0.00102713 (rank : 45)	NC score	0.744157 (rank : 30)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	75
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

ID4_HUMAN
θ value	0.00102713 (rank : 46)	NC score	0.495405 (rank : 54)
Query Neighborhood Hits	86	Target Neighborhood Hits	67	Shared Neighborhood Hits	58
SwissProt Accessions	P47928, Q13005	Gene names	ID4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID4_MOUSE
θ value	0.00102713 (rank : 47)	NC score	0.490122 (rank : 55)
Query Neighborhood Hits	86	Target Neighborhood Hits	66	Shared Neighborhood Hits	58
SwissProt Accessions	P41139	Gene names	Id4, Id-4, Idb4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ASCL1_MOUSE
θ value	0.00869519 (rank : 48)	NC score	0.650228 (rank : 43)
Query Neighborhood Hits	86	Target Neighborhood Hits	97	Shared Neighborhood Hits	70
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

ASCL1_HUMAN
θ value	0.0113563 (rank : 49)	NC score	0.647441 (rank : 46)
Query Neighborhood Hits	86	Target Neighborhood Hits	94	Shared Neighborhood Hits	70
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

ATOH1_HUMAN
θ value	0.0148317 (rank : 50)	NC score	0.679612 (rank : 41)
Query Neighborhood Hits	86	Target Neighborhood Hits	97	Shared Neighborhood Hits	75
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

ATOH1_MOUSE
θ value	0.0148317 (rank : 51)	NC score	0.681326 (rank : 40)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

ID2_HUMAN
θ value	0.0330416 (rank : 52)	NC score	0.378187 (rank : 66)
Query Neighborhood Hits	86	Target Neighborhood Hits	48	Shared Neighborhood Hits	47
SwissProt Accessions	Q02363	Gene names	ID2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

ID1_HUMAN
θ value	0.0563607 (rank : 53)	NC score	0.436743 (rank : 64)
Query Neighborhood Hits	86	Target Neighborhood Hits	63	Shared Neighborhood Hits	55
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

ID1_MOUSE
θ value	0.0563607 (rank : 54)	NC score	0.422690 (rank : 65)
Query Neighborhood Hits	86	Target Neighborhood Hits	64	Shared Neighborhood Hits	55
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

ID2_MOUSE
θ value	0.0736092 (rank : 55)	NC score	0.354018 (rank : 70)
Query Neighborhood Hits	86	Target Neighborhood Hits	47	Shared Neighborhood Hits	46
SwissProt Accessions	P41136, O88604	Gene names	Id2, Id-2, Idb2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

ITF2_MOUSE
θ value	0.0961366 (rank : 56)	NC score	0.189129 (rank : 79)
Query Neighborhood Hits	86	Target Neighborhood Hits	154	Shared Neighborhood Hits	43
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

ASCL2_MOUSE
θ value	0.125558 (rank : 57)	NC score	0.625102 (rank : 50)
Query Neighborhood Hits	86	Target Neighborhood Hits	98	Shared Neighborhood Hits	70
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

NDF6_HUMAN
θ value	0.163984 (rank : 58)	NC score	0.583319 (rank : 52)
Query Neighborhood Hits	86	Target Neighborhood Hits	91	Shared Neighborhood Hits	73
SwissProt Accessions	Q96NK8, Q9H3H6	Gene names	NEUROD6
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6).

NDF6_MOUSE
θ value	0.163984 (rank : 59)	NC score	0.582153 (rank : 53)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	73
SwissProt Accessions	P48986	Gene names	Neurod6, Ath2, Atoh2, Nex1
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6) (Atonal protein homolog 2) (Helix-loop-helix protein mATH-2) (MATH2) (NEX-1 protein).

MLX_MOUSE
θ value	0.21417 (rank : 60)	NC score	0.124480 (rank : 86)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	20
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

ITF2_HUMAN
θ value	0.279714 (rank : 61)	NC score	0.185849 (rank : 80)
Query Neighborhood Hits	86	Target Neighborhood Hits	168	Shared Neighborhood Hits	41
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

ASCL2_HUMAN
θ value	0.365318 (rank : 62)	NC score	0.649954 (rank : 45)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q99929, Q9UM68	Gene names	ASCL2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash2) (HASH2).

MLX_HUMAN
θ value	0.365318 (rank : 63)	NC score	0.115668 (rank : 88)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

OLIG2_MOUSE
θ value	0.365318 (rank : 64)	NC score	0.482880 (rank : 57)
Query Neighborhood Hits	86	Target Neighborhood Hits	74	Shared Neighborhood Hits	60
SwissProt Accessions	Q9EQW6, Q9JKN4	Gene names	Olig2
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2).

OLIG2_HUMAN
θ value	0.62314 (rank : 65)	NC score	0.476444 (rank : 58)
Query Neighborhood Hits	86	Target Neighborhood Hits	84	Shared Neighborhood Hits	61
SwissProt Accessions	Q13516, Q86X04, Q9NZ14	Gene names	OLIG2, BHLHB1, PRKCBP2, RACK17
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2) (Basic helix-loop- helix protein class B 1) (Protein kinase C-binding protein RACK17) (Protein kinase C-binding protein 2).

OLIG3_HUMAN
θ value	0.813845 (rank : 66)	NC score	0.463773 (rank : 61)
Query Neighborhood Hits	86	Target Neighborhood Hits	77	Shared Neighborhood Hits	57
SwissProt Accessions	Q7RTU3, Q8N8Q0	Gene names	OLIG3, BHLHB7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Basic helix-loop- helix domain-containing class B protein 7).

OLIG3_MOUSE
θ value	0.813845 (rank : 67)	NC score	0.468429 (rank : 60)
Query Neighborhood Hits	86	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PFG8, Q9EQW5	Gene names	Olig3, Bhlhb7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Oligodendrocyte- specific bHLH transcription factor 3) (Basic helix-loop-helix domain- containing class B protein 7).

HTF4_HUMAN
θ value	1.38821 (rank : 68)	NC score	0.160501 (rank : 82)
Query Neighborhood Hits	86	Target Neighborhood Hits	152	Shared Neighborhood Hits	44
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

HTF4_MOUSE
θ value	1.38821 (rank : 69)	NC score	0.162928 (rank : 81)
Query Neighborhood Hits	86	Target Neighborhood Hits	153	Shared Neighborhood Hits	44
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

SRBP1_MOUSE
θ value	1.81305 (rank : 70)	NC score	0.078776 (rank : 96)
Query Neighborhood Hits	86	Target Neighborhood Hits	384	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_HUMAN
θ value	2.36792 (rank : 71)	NC score	0.074485 (rank : 98)
Query Neighborhood Hits	86	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

WHRN_MOUSE
θ value	2.36792 (rank : 72)	NC score	0.009784 (rank : 106)
Query Neighborhood Hits	86	Target Neighborhood Hits	412	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

BMAL1_HUMAN
θ value	3.0926 (rank : 73)	NC score	0.043253 (rank : 103)
Query Neighborhood Hits	86	Target Neighborhood Hits	115	Shared Neighborhood Hits	21
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	3.0926 (rank : 74)	NC score	0.042655 (rank : 104)
Query Neighborhood Hits	86	Target Neighborhood Hits	121	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

ID3_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.256869 (rank : 76)
Query Neighborhood Hits	86	Target Neighborhood Hits	33	Shared Neighborhood Hits	33
SwissProt Accessions	Q02535, O75641	Gene names	ID3, 1R21, HEIR-1
Domain Architecture
Description	DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID- like protein inhibitor HLH 1R21) (Helix-loop-helix protein HEIR-1).

ID3_MOUSE
θ value	3.0926 (rank : 76)	NC score	0.258425 (rank : 75)
Query Neighborhood Hits	86	Target Neighborhood Hits	35	Shared Neighborhood Hits	35
SwissProt Accessions	P41133	Gene names	Id3, Hlh462, Id-3, Idb3
Domain Architecture
Description	DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID- like protein inhibitor HLH 462).

MYF5_HUMAN
θ value	4.03905 (rank : 77)	NC score	0.360201 (rank : 69)
Query Neighborhood Hits	86	Target Neighborhood Hits	80	Shared Neighborhood Hits	61
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYF5_MOUSE
θ value	4.03905 (rank : 78)	NC score	0.371472 (rank : 67)
Query Neighborhood Hits	86	Target Neighborhood Hits	77	Shared Neighborhood Hits	61
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

TFE2_MOUSE
θ value	4.03905 (rank : 79)	NC score	0.152627 (rank : 83)
Query Neighborhood Hits	86	Target Neighborhood Hits	118	Shared Neighborhood Hits	43
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

OLIG1_HUMAN
θ value	6.88961 (rank : 80)	NC score	0.446703 (rank : 62)
Query Neighborhood Hits	86	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TAK6, Q7RTS0	Gene names	OLIG1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1).

OLIG1_MOUSE
θ value	6.88961 (rank : 81)	NC score	0.443440 (rank : 63)
Query Neighborhood Hits	86	Target Neighborhood Hits	69	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JKN5	Gene names	Olig1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1) (Oligodendrocyte- specific bHLH transcription factor 1).

SRBP2_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.062873 (rank : 100)
Query Neighborhood Hits	86	Target Neighborhood Hits	133	Shared Neighborhood Hits	11
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

TFE2_HUMAN
θ value	6.88961 (rank : 83)	NC score	0.145734 (rank : 84)
Query Neighborhood Hits	86	Target Neighborhood Hits	161	Shared Neighborhood Hits	41
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

XBP1_MOUSE
θ value	6.88961 (rank : 84)	NC score	0.015991 (rank : 105)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	O35426, Q8VHM0, Q922G5, Q9ESS3	Gene names	Xbp1, Treb5
Domain Architecture	No domain graphic available
Description	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5 homolog).

IF4G3_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.006536 (rank : 107)
Query Neighborhood Hits	86	Target Neighborhood Hits	279	Shared Neighborhood Hits	3
SwissProt Accessions	Q80XI3, Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0	Gene names	Eif4g3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).

MNT_MOUSE
θ value	8.99809 (rank : 86)	NC score	0.097965 (rank : 93)
Query Neighborhood Hits	86	Target Neighborhood Hits	432	Shared Neighborhood Hits	35
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

BHLH4_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.484630 (rank : 56)
Query Neighborhood Hits	86	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NDY6	Gene names	BHLHB4
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

BHLH4_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.474857 (rank : 59)
Query Neighborhood Hits	86	Target Neighborhood Hits	71	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BGW3, Q71MB7	Gene names	Bhlhb4, H20
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

HEY2_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.053534 (rank : 102)
Query Neighborhood Hits	86	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.062678 (rank : 101)
Query Neighborhood Hits	86	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

MAX_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.112186 (rank : 89)
Query Neighborhood Hits	86	Target Neighborhood Hits	125	Shared Neighborhood Hits	25
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.117638 (rank : 87)
Query Neighborhood Hits	86	Target Neighborhood Hits	139	Shared Neighborhood Hits	26
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MNT_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.085734 (rank : 95)
Query Neighborhood Hits	86	Target Neighborhood Hits	496	Shared Neighborhood Hits	32
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYCL1_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.072880 (rank : 99)
Query Neighborhood Hits	86	Target Neighborhood Hits	146	Shared Neighborhood Hits	32
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.076827 (rank : 97)
Query Neighborhood Hits	86	Target Neighborhood Hits	123	Shared Neighborhood Hits	31
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCN_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.094808 (rank : 94)
Query Neighborhood Hits	86	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCN_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.098501 (rank : 92)
Query Neighborhood Hits	86	Target Neighborhood Hits	125	Shared Neighborhood Hits	33
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYCS_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.139231 (rank : 85)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MYC_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.101417 (rank : 91)
Query Neighborhood Hits	86	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.107107 (rank : 90)
Query Neighborhood Hits	86	Target Neighborhood Hits	125	Shared Neighborhood Hits	30
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYF6_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.284167 (rank : 73)
Query Neighborhood Hits	86	Target Neighborhood Hits	74	Shared Neighborhood Hits	51
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.282908 (rank : 74)
Query Neighborhood Hits	86	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

MYOD1_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.295472 (rank : 72)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	51
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOD1_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.297459 (rank : 71)
Query Neighborhood Hits	86	Target Neighborhood Hits	82	Shared Neighborhood Hits	51
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

MYOG_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.229290 (rank : 77)
Query Neighborhood Hits	86	Target Neighborhood Hits	67	Shared Neighborhood Hits	47
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
θ value	θ > 10 (rank : 106)	NC score	0.222207 (rank : 78)
Query Neighborhood Hits	86	Target Neighborhood Hits	71	Shared Neighborhood Hits	47
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

TFAP4_HUMAN
θ value	θ > 10 (rank : 107)	NC score	0.364958 (rank : 68)
Query Neighborhood Hits	86	Target Neighborhood Hits	289	Shared Neighborhood Hits	54
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

Hits sorted by NC score

HEN1_MOUSE
NC score	0.999962 (rank : 1)	θ value	3.74554e-30 (rank : 1)
Query Neighborhood Hits	86	Target Neighborhood Hits	86	Shared Neighborhood Hits	86
SwissProt Accessions	Q02576	Gene names	Nhlh1, Hen1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN1_HUMAN
NC score	0.997021 (rank : 2)	θ value	1.92365e-26 (rank : 2)
Query Neighborhood Hits	86	Target Neighborhood Hits	88	Shared Neighborhood Hits	83
SwissProt Accessions	Q02575	Gene names	NHLH1, HEN1
Domain Architecture
Description	Helix-loop-helix protein 1 (HEN1) (Nescient helix loop helix 1) (NSCL- 1).

HEN2_HUMAN
NC score	0.968549 (rank : 3)	θ value	2.88119e-14 (rank : 3)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	82
SwissProt Accessions	Q02577	Gene names	NHLH2, HEN2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

HEN2_MOUSE
NC score	0.966880 (rank : 4)	θ value	2.88119e-14 (rank : 4)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	82
SwissProt Accessions	Q64221	Gene names	Nhlh2, Hen2
Domain Architecture
Description	Helix-loop-helix protein 2 (HEN2) (Nescient helix loop helix 2) (NSCL- 2).

TAL2_HUMAN
NC score	0.904614 (rank : 5)	θ value	1.63604e-09 (rank : 8)
Query Neighborhood Hits	86	Target Neighborhood Hits	77	Shared Neighborhood Hits	70
SwissProt Accessions	Q16559	Gene names	TAL2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein (TAL-2 protein).

TAL2_MOUSE
NC score	0.903227 (rank : 6)	θ value	9.59137e-10 (rank : 7)
Query Neighborhood Hits	86	Target Neighborhood Hits	79	Shared Neighborhood Hits	70
SwissProt Accessions	Q62282	Gene names	Tal2
Domain Architecture
Description	T-cell acute lymphocytic leukemia-2 protein homolog (TAL-2 protein).

SCX_MOUSE
NC score	0.862194 (rank : 7)	θ value	1.80886e-08 (rank : 11)
Query Neighborhood Hits	86	Target Neighborhood Hits	82	Shared Neighborhood Hits	67
SwissProt Accessions	Q64124	Gene names	Scx
Domain Architecture
Description	Basic helix-loop-helix transcription factor scleraxis.

LYL1_HUMAN
NC score	0.859344 (rank : 8)	θ value	2.79066e-09 (rank : 9)
Query Neighborhood Hits	86	Target Neighborhood Hits	113	Shared Neighborhood Hits	74
SwissProt Accessions	P12980, O76102	Gene names	LYL1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

TAL1_HUMAN
NC score	0.848161 (rank : 9)	θ value	9.59137e-10 (rank : 5)
Query Neighborhood Hits	86	Target Neighborhood Hits	112	Shared Neighborhood Hits	79
SwissProt Accessions	P17542	Gene names	TAL1, SCL, TCL5
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein).

TAL1_MOUSE
NC score	0.847967 (rank : 10)	θ value	9.59137e-10 (rank : 6)
Query Neighborhood Hits	86	Target Neighborhood Hits	110	Shared Neighborhood Hits	79
SwissProt Accessions	P22091	Gene names	Tal1, Scl, Tal-1
Domain Architecture
Description	T-cell acute lymphocytic leukemia-1 protein homolog (TAL-1 protein) (Stem cell protein).

LYL1_MOUSE
NC score	0.844742 (rank : 11)	θ value	2.79066e-09 (rank : 10)
Query Neighborhood Hits	86	Target Neighborhood Hits	102	Shared Neighborhood Hits	76
SwissProt Accessions	P27792	Gene names	Lyl1, Lyl-1
Domain Architecture
Description	Protein lyl-1 (Lymphoblastic leukemia-derived sequence 1).

TCF15_HUMAN
NC score	0.837229 (rank : 12)	θ value	4.92598e-06 (rank : 23)
Query Neighborhood Hits	86	Target Neighborhood Hits	79	Shared Neighborhood Hits	66
SwissProt Accessions	Q12870, Q9NQQ1	Gene names	TCF15, BHLHEC2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis).

HAND2_HUMAN
NC score	0.834034 (rank : 13)	θ value	1.53129e-07 (rank : 14)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	78
SwissProt Accessions	P61296, O95300, O95301, P97833	Gene names	HAND2, DHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND).

HAND2_MOUSE
NC score	0.834034 (rank : 14)	θ value	1.53129e-07 (rank : 15)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	78
SwissProt Accessions	Q61039, Q61100	Gene names	Hand2, Dhand, Hed, Thing2
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 2 (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND) (Helix-loop-helix transcription factor expressed in embryo and deciduum) (Thing-2).

TCF15_MOUSE
NC score	0.833772 (rank : 15)	θ value	2.21117e-06 (rank : 22)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	67
SwissProt Accessions	Q60756, Q60788	Gene names	Tcf15, Bhlhec2
Domain Architecture
Description	Transcription factor 15 (bHLH-EC2 protein) (Paraxis) (Meso1).

HAND1_HUMAN
NC score	0.831180 (rank : 16)	θ value	5.26297e-08 (rank : 13)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	73
SwissProt Accessions	O96004	Gene names	HAND1, EHAND
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND).

HAND1_MOUSE
NC score	0.824207 (rank : 17)	θ value	3.08544e-08 (rank : 12)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q64279, Q61099	Gene names	Hand1, Ehand, Hxt, Thing1
Domain Architecture
Description	Heart- and neural crest derivatives-expressed protein 1 (Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1) (eHAND) (Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast) (Thing-1) (Th1).

TWST1_HUMAN
NC score	0.818310 (rank : 18)	θ value	5.81887e-07 (rank : 20)
Query Neighborhood Hits	86	Target Neighborhood Hits	93	Shared Neighborhood Hits	72
SwissProt Accessions	Q15672, Q92487, Q99804	Gene names	TWIST1, TWIST
Domain Architecture
Description	Twist-related protein 1 (H-twist).

TWST1_MOUSE
NC score	0.817809 (rank : 19)	θ value	5.81887e-07 (rank : 21)
Query Neighborhood Hits	86	Target Neighborhood Hits	101	Shared Neighborhood Hits	72
SwissProt Accessions	P26687	Gene names	Twist1, Twist
Domain Architecture
Description	Twist-related protein 1 (M-twist).

TWST2_MOUSE
NC score	0.803648 (rank : 20)	θ value	2.61198e-07 (rank : 17)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q9D030	Gene names	Twist2, Dermo1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

TWST2_HUMAN
NC score	0.803466 (rank : 21)	θ value	2.61198e-07 (rank : 16)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	72
SwissProt Accessions	Q8WVJ9	Gene names	TWIST2, DERMO1
Domain Architecture
Description	Twist-related protein 2 (Dermis expressed protein 1) (Dermo-1).

PTF1A_HUMAN
NC score	0.785020 (rank : 22)	θ value	4.45536e-07 (rank : 18)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	74
SwissProt Accessions	Q7RTS3, Q9HC25	Gene names	PTF1A, PTF1P48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

PTF1A_MOUSE
NC score	0.778872 (rank : 23)	θ value	4.45536e-07 (rank : 19)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	74
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

TCF21_HUMAN
NC score	0.758465 (rank : 24)	θ value	0.000270298 (rank : 37)
Query Neighborhood Hits	86	Target Neighborhood Hits	68	Shared Neighborhood Hits	65
SwissProt Accessions	O43680, O43545, Q9BZ14	Gene names	TCF21, POD1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

MUSC_MOUSE
NC score	0.758416 (rank : 25)	θ value	0.000602161 (rank : 43)
Query Neighborhood Hits	86	Target Neighborhood Hits	78	Shared Neighborhood Hits	69
SwissProt Accessions	O88940	Gene names	Msc, Myor
Domain Architecture
Description	Musculin (Myogenic repressor).

TCF21_MOUSE
NC score	0.755018 (rank : 26)	θ value	0.000270298 (rank : 38)
Query Neighborhood Hits	86	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	O35437, Q3U023	Gene names	Tcf21, Pod1
Domain Architecture
Description	Transcription factor 21 (Podocyte-expressed 1) (Pod-1) (Epicardin) (Capsulin).

MUSC_HUMAN
NC score	0.752637 (rank : 27)	θ value	0.000602161 (rank : 42)
Query Neighborhood Hits	86	Target Neighborhood Hits	78	Shared Neighborhood Hits	69
SwissProt Accessions	O60682, O75946, Q9BRE7	Gene names	MSC, ABF1
Domain Architecture
Description	Musculin (Activated B-cell factor 1) (ABF-1).

NGN2_HUMAN
NC score	0.750264 (rank : 28)	θ value	3.19293e-05 (rank : 27)
Query Neighborhood Hits	86	Target Neighborhood Hits	92	Shared Neighborhood Hits	67
SwissProt Accessions	Q9H2A3, Q8N416	Gene names	NEUROG2, NGN2
Domain Architecture	No domain graphic available
Description	Neurogenin 2.

NGN2_MOUSE
NC score	0.749085 (rank : 29)	θ value	2.44474e-05 (rank : 26)
Query Neighborhood Hits	86	Target Neighborhood Hits	106	Shared Neighborhood Hits	67
SwissProt Accessions	P70447, P70237	Gene names	Neurog2, Ath4a, Atoh4, Ngn2
Domain Architecture
Description	Neurogenin 2 (Atonal protein homolog 4) (Helix-loop-helix protein mATH-4A) (MATH4A).

BHLH8_MOUSE
NC score	0.744157 (rank : 30)	θ value	0.00102713 (rank : 45)
Query Neighborhood Hits	86	Target Neighborhood Hits	107	Shared Neighborhood Hits	75
SwissProt Accessions	Q9QYC3, Q9QYE4	Gene names	Bhlhb8, Mist1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

NGN3_MOUSE
NC score	0.742115 (rank : 31)	θ value	1.43324e-05 (rank : 25)
Query Neighborhood Hits	86	Target Neighborhood Hits	90	Shared Neighborhood Hits	68
SwissProt Accessions	P70661	Gene names	Neurog3, Ath4b, Atoh5, Ngn3
Domain Architecture
Description	Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B).

NGN3_HUMAN
NC score	0.738401 (rank : 32)	θ value	1.43324e-05 (rank : 24)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y4Z2, Q9BY24	Gene names	NEUROG3, NGN3
Domain Architecture
Description	Neurogenin 3.

BHLH8_HUMAN
NC score	0.736271 (rank : 33)	θ value	0.00102713 (rank : 44)
Query Neighborhood Hits	86	Target Neighborhood Hits	123	Shared Neighborhood Hits	75
SwissProt Accessions	Q7RTS1	Gene names	BHLHB8, MIST1
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 8 (bHLHB8) (Muscle, intestine and stomach expression 1) (MIST-1).

NGN1_HUMAN
NC score	0.734645 (rank : 34)	θ value	0.00035302 (rank : 40)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	69
SwissProt Accessions	Q92886, Q96HE1	Gene names	NEUROG1, NEUROD3, NGN, NGN1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein).

NGN1_MOUSE
NC score	0.732566 (rank : 35)	θ value	0.00035302 (rank : 41)
Query Neighborhood Hits	86	Target Neighborhood Hits	87	Shared Neighborhood Hits	71
SwissProt Accessions	P70660	Gene names	Neurog1, Ath4c, Neurod3, Ngn, Ngn1
Domain Architecture
Description	Neurogenin 1 (Neurogenic differentiation factor 3) (NeuroD3) (Neurogenic basic-helix-loop-helix protein) (Helix-loop-helix protein mATH-4C) (MATH4C).

ASCL3_MOUSE
NC score	0.725092 (rank : 36)	θ value	4.1701e-05 (rank : 28)
Query Neighborhood Hits	86	Target Neighborhood Hits	70	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JJR7	Gene names	Ascl3, Mash3, Sgn1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1) (Mash- 3).

FIGLA_MOUSE
NC score	0.718389 (rank : 37)	θ value	0.00020696 (rank : 32)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	O55208	Gene names	Figla
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

FIGLA_HUMAN
NC score	0.713829 (rank : 38)	θ value	0.00035302 (rank : 39)
Query Neighborhood Hits	86	Target Neighborhood Hits	108	Shared Neighborhood Hits	77
SwissProt Accessions	Q6QHK4	Gene names	FIGLA
Domain Architecture	No domain graphic available
Description	Factor in the germline alpha (Transcription factor FIGa) (FIGalpha).

ASCL3_HUMAN
NC score	0.709259 (rank : 39)	θ value	9.29e-05 (rank : 31)
Query Neighborhood Hits	86	Target Neighborhood Hits	70	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NQ33, Q8WYQ6	Gene names	ASCL3, HASH3, SGN1
Domain Architecture
Description	Achaete-scute homolog 3 (bHLH transcriptional regulator Sgn-1).

ATOH1_MOUSE
NC score	0.681326 (rank : 40)	θ value	0.0148317 (rank : 51)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	P48985	Gene names	Atoh1, Ath1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein mATH-1) (MATH1).

ATOH1_HUMAN
NC score	0.679612 (rank : 41)	θ value	0.0148317 (rank : 50)
Query Neighborhood Hits	86	Target Neighborhood Hits	97	Shared Neighborhood Hits	75
SwissProt Accessions	Q92858	Gene names	ATOH1, ATH1
Domain Architecture
Description	Atonal protein homolog 1 (Helix-loop-helix protein hATH-1).

NDF4_HUMAN
NC score	0.650688 (rank : 42)	θ value	7.1131e-05 (rank : 29)
Query Neighborhood Hits	86	Target Neighborhood Hits	91	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HD90	Gene names	NEUROD4
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4).

ASCL1_MOUSE
NC score	0.650228 (rank : 43)	θ value	0.00869519 (rank : 48)
Query Neighborhood Hits	86	Target Neighborhood Hits	97	Shared Neighborhood Hits	70
SwissProt Accessions	Q02067	Gene names	Ascl1, Ash1, Mash-1, Mash1
Domain Architecture
Description	Achaete-scute homolog 1 (Mash-1).

NDF4_MOUSE
NC score	0.650033 (rank : 44)	θ value	7.1131e-05 (rank : 30)
Query Neighborhood Hits	86	Target Neighborhood Hits	105	Shared Neighborhood Hits	71
SwissProt Accessions	O09105	Gene names	Neurod4, Ath3, Atoh3
Domain Architecture
Description	Neurogenic differentiation factor 4 (NeuroD4) (Atonal protein homolog 3) (Helix-loop-helix protein mATH-3) (MATH3).

ASCL2_HUMAN
NC score	0.649954 (rank : 45)	θ value	0.365318 (rank : 62)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	71
SwissProt Accessions	Q99929, Q9UM68	Gene names	ASCL2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash2) (HASH2).

ASCL1_HUMAN
NC score	0.647441 (rank : 46)	θ value	0.0113563 (rank : 49)
Query Neighborhood Hits	86	Target Neighborhood Hits	94	Shared Neighborhood Hits	70
SwissProt Accessions	P50553, Q9BQ30	Gene names	ASCL1, ASH1
Domain Architecture
Description	Achaete-scute homolog 1 (HASH1).

NDF2_HUMAN
NC score	0.639779 (rank : 47)	θ value	0.000270298 (rank : 35)
Query Neighborhood Hits	86	Target Neighborhood Hits	113	Shared Neighborhood Hits	71
SwissProt Accessions	Q15784, Q8TBI7, Q9UQC6	Gene names	NEUROD2, NDRF
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF2_MOUSE
NC score	0.639253 (rank : 48)	θ value	0.000270298 (rank : 36)
Query Neighborhood Hits	86	Target Neighborhood Hits	111	Shared Neighborhood Hits	71
SwissProt Accessions	Q62414, Q61952, Q925V5	Gene names	Neurod2, Ndrf
Domain Architecture
Description	Neurogenic differentiation factor 2 (NeuroD2) (NeuroD-related factor) (NDRF).

NDF1_HUMAN
NC score	0.627560 (rank : 49)	θ value	0.000270298 (rank : 33)
Query Neighborhood Hits	86	Target Neighborhood Hits	186	Shared Neighborhood Hits	68
SwissProt Accessions	Q13562, O00343, Q13340, Q5U095, Q96TH0, Q99455, Q9UEC8	Gene names	NEUROD1, NEUROD
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1) (NeuroD).

ASCL2_MOUSE
NC score	0.625102 (rank : 50)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	86	Target Neighborhood Hits	98	Shared Neighborhood Hits	70
SwissProt Accessions	O35885, Q9WUJ7	Gene names	Ascl2, Mash2
Domain Architecture
Description	Achaete-scute homolog 2 (Mash-2).

NDF1_MOUSE
NC score	0.623069 (rank : 51)	θ value	0.000270298 (rank : 34)
Query Neighborhood Hits	86	Target Neighborhood Hits	209	Shared Neighborhood Hits	68
SwissProt Accessions	Q60867, Q545N9, Q60897	Gene names	Neurod1, Neurod
Domain Architecture
Description	Neurogenic differentiation factor 1 (NeuroD1).

NDF6_HUMAN
NC score	0.583319 (rank : 52)	θ value	0.163984 (rank : 58)
Query Neighborhood Hits	86	Target Neighborhood Hits	91	Shared Neighborhood Hits	73
SwissProt Accessions	Q96NK8, Q9H3H6	Gene names	NEUROD6
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6).

NDF6_MOUSE
NC score	0.582153 (rank : 53)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	73
SwissProt Accessions	P48986	Gene names	Neurod6, Ath2, Atoh2, Nex1
Domain Architecture
Description	Neurogenic differentiation factor 6 (NeuroD6) (Atonal protein homolog 2) (Helix-loop-helix protein mATH-2) (MATH2) (NEX-1 protein).

ID4_HUMAN
NC score	0.495405 (rank : 54)	θ value	0.00102713 (rank : 46)
Query Neighborhood Hits	86	Target Neighborhood Hits	67	Shared Neighborhood Hits	58
SwissProt Accessions	P47928, Q13005	Gene names	ID4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

ID4_MOUSE
NC score	0.490122 (rank : 55)	θ value	0.00102713 (rank : 47)
Query Neighborhood Hits	86	Target Neighborhood Hits	66	Shared Neighborhood Hits	58
SwissProt Accessions	P41139	Gene names	Id4, Id-4, Idb4
Domain Architecture
Description	DNA-binding protein inhibitor ID-4 (Inhibitor of DNA binding 4).

BHLH4_HUMAN
NC score	0.484630 (rank : 56)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	86	Target Neighborhood Hits	70	Shared Neighborhood Hits	56
SwissProt Accessions	Q8NDY6	Gene names	BHLHB4
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

OLIG2_MOUSE
NC score	0.482880 (rank : 57)	θ value	0.365318 (rank : 64)
Query Neighborhood Hits	86	Target Neighborhood Hits	74	Shared Neighborhood Hits	60
SwissProt Accessions	Q9EQW6, Q9JKN4	Gene names	Olig2
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2).

OLIG2_HUMAN
NC score	0.476444 (rank : 58)	θ value	0.62314 (rank : 65)
Query Neighborhood Hits	86	Target Neighborhood Hits	84	Shared Neighborhood Hits	61
SwissProt Accessions	Q13516, Q86X04, Q9NZ14	Gene names	OLIG2, BHLHB1, PRKCBP2, RACK17
Domain Architecture
Description	Oligodendrocyte transcription factor 2 (Oligo2) (Basic helix-loop- helix protein class B 1) (Protein kinase C-binding protein RACK17) (Protein kinase C-binding protein 2).

BHLH4_MOUSE
NC score	0.474857 (rank : 59)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	86	Target Neighborhood Hits	71	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BGW3, Q71MB7	Gene names	Bhlhb4, H20
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

OLIG3_MOUSE
NC score	0.468429 (rank : 60)	θ value	0.813845 (rank : 67)
Query Neighborhood Hits	86	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PFG8, Q9EQW5	Gene names	Olig3, Bhlhb7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Oligodendrocyte- specific bHLH transcription factor 3) (Basic helix-loop-helix domain- containing class B protein 7).

OLIG3_HUMAN
NC score	0.463773 (rank : 61)	θ value	0.813845 (rank : 66)
Query Neighborhood Hits	86	Target Neighborhood Hits	77	Shared Neighborhood Hits	57
SwissProt Accessions	Q7RTU3, Q8N8Q0	Gene names	OLIG3, BHLHB7
Domain Architecture	No domain graphic available
Description	Oligodendrocyte transcription factor 3 (Oligo3) (Basic helix-loop- helix domain-containing class B protein 7).

OLIG1_HUMAN
NC score	0.446703 (rank : 62)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	86	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TAK6, Q7RTS0	Gene names	OLIG1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1).

OLIG1_MOUSE
NC score	0.443440 (rank : 63)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	86	Target Neighborhood Hits	69	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JKN5	Gene names	Olig1
Domain Architecture
Description	Oligodendrocyte transcription factor 1 (Oligo1) (Oligodendrocyte- specific bHLH transcription factor 1).

ID1_HUMAN
NC score	0.436743 (rank : 64)	θ value	0.0563607 (rank : 53)
Query Neighborhood Hits	86	Target Neighborhood Hits	63	Shared Neighborhood Hits	55
SwissProt Accessions	P41134, O00651, O00652, Q16371, Q16377, Q5TE66, Q5TE67, Q969Z7, Q9H0Z5, Q9H109	Gene names	ID1, ID
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

ID1_MOUSE
NC score	0.422690 (rank : 65)	θ value	0.0563607 (rank : 54)
Query Neighborhood Hits	86	Target Neighborhood Hits	64	Shared Neighborhood Hits	55
SwissProt Accessions	P20067, Q61101, Q9D897	Gene names	Id1, Id, Id-1, Idb1
Domain Architecture
Description	DNA-binding protein inhibitor ID-1 (Inhibitor of DNA binding 1).

ID2_HUMAN
NC score	0.378187 (rank : 66)	θ value	0.0330416 (rank : 52)
Query Neighborhood Hits	86	Target Neighborhood Hits	48	Shared Neighborhood Hits	47
SwissProt Accessions	Q02363	Gene names	ID2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

MYF5_MOUSE
NC score	0.371472 (rank : 67)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	86	Target Neighborhood Hits	77	Shared Neighborhood Hits	61
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

TFAP4_HUMAN
NC score	0.364958 (rank : 68)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	86	Target Neighborhood Hits	289	Shared Neighborhood Hits	54
SwissProt Accessions	Q01664, O60409	Gene names	TFAP4
Domain Architecture
Description	Transcription factor AP-4 (Activating enhancer-binding protein 4).

MYF5_HUMAN
NC score	0.360201 (rank : 69)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	86	Target Neighborhood Hits	80	Shared Neighborhood Hits	61
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

ID2_MOUSE
NC score	0.354018 (rank : 70)	θ value	0.0736092 (rank : 55)
Query Neighborhood Hits	86	Target Neighborhood Hits	47	Shared Neighborhood Hits	46
SwissProt Accessions	P41136, O88604	Gene names	Id2, Id-2, Idb2
Domain Architecture
Description	DNA-binding protein inhibitor ID-2 (Inhibitor of DNA binding 2).

MYOD1_MOUSE
NC score	0.297459 (rank : 71)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	86	Target Neighborhood Hits	82	Shared Neighborhood Hits	51
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

MYOD1_HUMAN
NC score	0.295472 (rank : 72)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	51
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYF6_HUMAN
NC score	0.284167 (rank : 73)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	86	Target Neighborhood Hits	74	Shared Neighborhood Hits	51
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
NC score	0.282908 (rank : 74)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	86	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

ID3_MOUSE
NC score	0.258425 (rank : 75)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	86	Target Neighborhood Hits	35	Shared Neighborhood Hits	35
SwissProt Accessions	P41133	Gene names	Id3, Hlh462, Id-3, Idb3
Domain Architecture
Description	DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID- like protein inhibitor HLH 462).

ID3_HUMAN
NC score	0.256869 (rank : 76)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	86	Target Neighborhood Hits	33	Shared Neighborhood Hits	33
SwissProt Accessions	Q02535, O75641	Gene names	ID3, 1R21, HEIR-1
Domain Architecture
Description	DNA-binding protein inhibitor ID-3 (Inhibitor of DNA binding 3) (ID- like protein inhibitor HLH 1R21) (Helix-loop-helix protein HEIR-1).

MYOG_HUMAN
NC score	0.229290 (rank : 77)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	86	Target Neighborhood Hits	67	Shared Neighborhood Hits	47
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
NC score	0.222207 (rank : 78)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	86	Target Neighborhood Hits	71	Shared Neighborhood Hits	47
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

ITF2_MOUSE
NC score	0.189129 (rank : 79)	θ value	0.0961366 (rank : 56)
Query Neighborhood Hits	86	Target Neighborhood Hits	154	Shared Neighborhood Hits	43
SwissProt Accessions	Q60722, Q60721, Q62211, Q64072, Q80UE8	Gene names	Tcf4, Itf2, Sef2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2).

ITF2_HUMAN
NC score	0.185849 (rank : 80)	θ value	0.279714 (rank : 61)
Query Neighborhood Hits	86	Target Neighborhood Hits	168	Shared Neighborhood Hits	41
SwissProt Accessions	P15884, Q15439, Q15440	Gene names	TCF4, ITF2, SEF2
Domain Architecture
Description	Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2).

HTF4_MOUSE
NC score	0.162928 (rank : 81)	θ value	1.38821 (rank : 69)
Query Neighborhood Hits	86	Target Neighborhood Hits	153	Shared Neighborhood Hits	44
SwissProt Accessions	Q61286	Gene names	Tcf12, Alf1, Meb
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4) (Class A helix-loop-helix transcription factor ME1).

HTF4_HUMAN
NC score	0.160501 (rank : 82)	θ value	1.38821 (rank : 68)
Query Neighborhood Hits	86	Target Neighborhood Hits	152	Shared Neighborhood Hits	44
SwissProt Accessions	Q99081	Gene names	TCF12, HEB, HTF4
Domain Architecture
Description	Transcription factor 12 (Transcription factor HTF-4) (E-box-binding protein) (DNA-binding protein HTF4).

TFE2_MOUSE
NC score	0.152627 (rank : 83)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	86	Target Neighborhood Hits	118	Shared Neighborhood Hits	43
SwissProt Accessions	P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4	Gene names	Tcf3, Alf2, Me2, Tcfe2a
Domain Architecture	No domain graphic available
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1).

TFE2_HUMAN
NC score	0.145734 (rank : 84)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	86	Target Neighborhood Hits	161	Shared Neighborhood Hits	41
SwissProt Accessions	P15923, P15883, Q14208, Q14635, Q14636, Q9UPI9	Gene names	TCF3, E2A, ITF1
Domain Architecture
Description	Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Immunoglobulin transcription factor 1) (Transcription factor ITF-1) (Kappa-E2-binding factor).

MYCS_MOUSE
NC score	0.139231 (rank : 85)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	86	Target Neighborhood Hits	83	Shared Neighborhood Hits	44
SwissProt Accessions	Q9Z304	Gene names	Mycs
Domain Architecture
Description	Protein S-myc.

MLX_MOUSE
NC score	0.124480 (rank : 86)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	86	Target Neighborhood Hits	100	Shared Neighborhood Hits	20
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MAX_MOUSE
NC score	0.117638 (rank : 87)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	86	Target Neighborhood Hits	139	Shared Neighborhood Hits	26
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MLX_HUMAN
NC score	0.115668 (rank : 88)	θ value	0.365318 (rank : 63)
Query Neighborhood Hits	86	Target Neighborhood Hits	95	Shared Neighborhood Hits	20
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MAX_HUMAN
NC score	0.112186 (rank : 89)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	86	Target Neighborhood Hits	125	Shared Neighborhood Hits	25
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MYC_MOUSE
NC score	0.107107 (rank : 90)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	86	Target Neighborhood Hits	125	Shared Neighborhood Hits	30
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYC_HUMAN
NC score	0.101417 (rank : 91)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	86	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MYCN_MOUSE
NC score	0.098501 (rank : 92)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	86	Target Neighborhood Hits	125	Shared Neighborhood Hits	33
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MNT_MOUSE
NC score	0.097965 (rank : 93)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	86	Target Neighborhood Hits	432	Shared Neighborhood Hits	35
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

MYCN_HUMAN
NC score	0.094808 (rank : 94)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	86	Target Neighborhood Hits	127	Shared Neighborhood Hits	33
SwissProt Accessions	P04198, Q6LDT9	Gene names	MYCN, NMYC
Domain Architecture
Description	N-myc proto-oncogene protein.

MNT_HUMAN
NC score	0.085734 (rank : 95)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	86	Target Neighborhood Hits	496	Shared Neighborhood Hits	32
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

SRBP1_MOUSE
NC score	0.078776 (rank : 96)	θ value	1.81305 (rank : 70)
Query Neighborhood Hits	86	Target Neighborhood Hits	384	Shared Neighborhood Hits	20
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYCL1_MOUSE
NC score	0.076827 (rank : 97)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	86	Target Neighborhood Hits	123	Shared Neighborhood Hits	31
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

SRBP1_HUMAN
NC score	0.074485 (rank : 98)	θ value	2.36792 (rank : 71)
Query Neighborhood Hits	86	Target Neighborhood Hits	225	Shared Neighborhood Hits	21
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MYCL1_HUMAN
NC score	0.072880 (rank : 99)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	86	Target Neighborhood Hits	146	Shared Neighborhood Hits	32
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

SRBP2_HUMAN
NC score	0.062873 (rank : 100)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	86	Target Neighborhood Hits	133	Shared Neighborhood Hits	11
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

HEY2_MOUSE
NC score	0.062678 (rank : 101)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	86	Target Neighborhood Hits	80	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
NC score	0.053534 (rank : 102)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	86	Target Neighborhood Hits	77	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

BMAL1_HUMAN
NC score	0.043253 (rank : 103)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	86	Target Neighborhood Hits	115	Shared Neighborhood Hits	21
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
NC score	0.042655 (rank : 104)	θ value	3.0926 (rank : 74)
Query Neighborhood Hits	86	Target Neighborhood Hits	121	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

XBP1_MOUSE
NC score	0.015991 (rank : 105)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	86	Target Neighborhood Hits	99	Shared Neighborhood Hits	4
SwissProt Accessions	O35426, Q8VHM0, Q922G5, Q9ESS3	Gene names	Xbp1, Treb5
Domain Architecture	No domain graphic available
Description	X box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5 homolog).

WHRN_MOUSE
NC score	0.009784 (rank : 106)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	86	Target Neighborhood Hits	412	Shared Neighborhood Hits	5
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

IF4G3_MOUSE
NC score	0.006536 (rank : 107)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	86	Target Neighborhood Hits	279	Shared Neighborhood Hits	3
SwissProt Accessions	Q80XI3, Q80Y69, Q8BJ68, Q8BQF3, Q8C6Q3, Q8CIH0	Gene names	Eif4g3
Domain Architecture
Description	Eukaryotic translation initiation factor 4 gamma 3 (eIF-4-gamma 3) (eIF-4G 3) (eIF4G 3) (eIF-4-gamma II) (eIF4GII).