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Network neighborhood for query Sequence : BHLH2_MOUSE

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BHLH2_MOUSE
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BHLH2_HUMAN
θ value	0 (rank : 1)	NC score	0.992403 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	80	Shared Neighborhood Hits	57
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_MOUSE
θ value	9.76566e-63 (rank : 3)	NC score	0.935672 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	50
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
θ value	1.61343e-57 (rank : 4)	NC score	0.926259 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

HES4_HUMAN
θ value	8.11959e-09 (rank : 5)	NC score	0.597139 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	58	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_HUMAN
θ value	5.26297e-08 (rank : 6)	NC score	0.566630 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	5.26297e-08 (rank : 7)	NC score	0.563815 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	78	Shared Neighborhood Hits	36
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HEY1_HUMAN
θ value	2.88788e-06 (rank : 8)	NC score	0.510443 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
θ value	2.88788e-06 (rank : 9)	NC score	0.516869 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	2.88788e-06 (rank : 10)	NC score	0.519838 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	2.88788e-06 (rank : 11)	NC score	0.525737 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HES2_MOUSE
θ value	7.1131e-05 (rank : 12)	NC score	0.513980 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
θ value	0.00035302 (rank : 13)	NC score	0.508893 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES5_MOUSE
θ value	0.00035302 (rank : 14)	NC score	0.548708 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	29
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES7_MOUSE
θ value	0.00035302 (rank : 15)	NC score	0.417193 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES6_HUMAN
θ value	0.000602161 (rank : 16)	NC score	0.458028 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
θ value	0.000786445 (rank : 17)	NC score	0.440288 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES3_MOUSE
θ value	0.00390308 (rank : 18)	NC score	0.467223 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

SRBP2_HUMAN
θ value	0.0193708 (rank : 19)	NC score	0.202030 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	133	Shared Neighborhood Hits	41
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

HES7_HUMAN
θ value	0.0330416 (rank : 20)	NC score	0.394978 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

MAD1_MOUSE
θ value	0.0330416 (rank : 21)	NC score	0.187960 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	75	Shared Neighborhood Hits	29
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SRBP1_MOUSE
θ value	0.0563607 (rank : 22)	NC score	0.184509 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	384	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

BMAL1_HUMAN
θ value	0.0736092 (rank : 23)	NC score	0.168582 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	0.0736092 (rank : 24)	NC score	0.169481 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	121	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

MAD1_HUMAN
θ value	0.0961366 (rank : 25)	NC score	0.179008 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	68	Shared Neighborhood Hits	29
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SRBP1_HUMAN
θ value	0.125558 (rank : 26)	NC score	0.187466 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

ARNT2_MOUSE
θ value	0.279714 (rank : 27)	NC score	0.126585 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

USF1_HUMAN
θ value	0.279714 (rank : 28)	NC score	0.200889 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	43
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	0.279714 (rank : 29)	NC score	0.201137 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	71	Shared Neighborhood Hits	43
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

NPAS2_HUMAN
θ value	0.365318 (rank : 30)	NC score	0.110609 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	150	Shared Neighborhood Hits	29
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	0.365318 (rank : 31)	NC score	0.110622 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	132	Shared Neighborhood Hits	30
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

MAD4_HUMAN
θ value	0.813845 (rank : 32)	NC score	0.146579 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	94	Shared Neighborhood Hits	35
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MLX_MOUSE
θ value	0.813845 (rank : 33)	NC score	0.176044 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

CN048_HUMAN
θ value	1.06291 (rank : 34)	NC score	0.098417 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NCU1, Q8N7S1	Gene names	C14orf48
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf48.

MLX_HUMAN
θ value	1.06291 (rank : 35)	NC score	0.174464 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	95	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MXI1_HUMAN
θ value	1.06291 (rank : 36)	NC score	0.164104 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	28
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	1.06291 (rank : 37)	NC score	0.162617 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	28
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

ARNT2_HUMAN
θ value	1.38821 (rank : 38)	NC score	0.120346 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.121873 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	1.38821 (rank : 40)	NC score	0.124367 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	213	Shared Neighborhood Hits	39
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

MAD3_HUMAN
θ value	1.38821 (rank : 41)	NC score	0.139083 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	92	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MYC_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.085370 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

PHLB1_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.021485 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	1038	Shared Neighborhood Hits	8
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PRDM1_MOUSE
θ value	1.38821 (rank : 44)	NC score	0.002419 (rank : 75)
Query Neighborhood Hits	70	Target Neighborhood Hits	766	Shared Neighborhood Hits	3
SwissProt Accessions	Q60636	Gene names	Prdm1, Blimp1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1).

MEOX2_MOUSE
θ value	1.81305 (rank : 45)	NC score	0.016831 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	341	Shared Neighborhood Hits	4
SwissProt Accessions	P32443, Q544T6	Gene names	Meox2, Gax, Mox-2, Mox2
Domain Architecture
Description	Homeobox protein MOX-2 (Mesenchyme homeobox 2).

USF2_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.168124 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	155	Shared Neighborhood Hits	42
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	1.81305 (rank : 47)	NC score	0.170481 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	173	Shared Neighborhood Hits	43
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

CLOCK_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.110722 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	127	Shared Neighborhood Hits	31
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	2.36792 (rank : 49)	NC score	0.107885 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MAD3_MOUSE
θ value	2.36792 (rank : 50)	NC score	0.119760 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	94	Shared Neighborhood Hits	25
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

TFE3_HUMAN
θ value	2.36792 (rank : 51)	NC score	0.145124 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

BACH2_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.007757 (rank : 73)
Query Neighborhood Hits	70	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	P97303	Gene names	Bach2
Domain Architecture
Description	Transcription regulator protein BACH2 (BTB and CNC homolog 2).

CCD93_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.018822 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	362	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

MITF_MOUSE
θ value	4.03905 (rank : 54)	NC score	0.124687 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MYCL1_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.089106 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.092237 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

PSB10_HUMAN
θ value	4.03905 (rank : 57)	NC score	0.014027 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P40306, Q5U098	Gene names	PSMB10, MECL1
Domain Architecture
Description	Proteasome subunit beta type 10 precursor (EC 3.4.25.1) (Proteasome MECl-1) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1).

CHD6_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.006689 (rank : 74)
Query Neighborhood Hits	70	Target Neighborhood Hits	342	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

MEOX2_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.013185 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	340	Shared Neighborhood Hits	4
SwissProt Accessions	P50222, O75263, Q9UPL6	Gene names	MEOX2, GAX, MOX2
Domain Architecture
Description	Homeobox protein MOX-2 (Mesenchyme homeobox 2) (Growth arrest-specific homeobox).

NAC1_MOUSE
θ value	5.27518 (rank : 60)	NC score	0.015653 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P70414	Gene names	Slc8a1, Ncx
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

PTF1A_MOUSE
θ value	5.27518 (rank : 61)	NC score	0.014146 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	100	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

REST_MOUSE
θ value	5.27518 (rank : 62)	NC score	0.001711 (rank : 76)
Query Neighborhood Hits	70	Target Neighborhood Hits	1506	Shared Neighborhood Hits	8
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

CCD93_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.012868 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	600	Shared Neighborhood Hits	5
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

EDF1_MOUSE
θ value	6.88961 (rank : 64)	NC score	0.019323 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JMG1, Q99NE6	Gene names	Edf1
Domain Architecture	No domain graphic available
Description	Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein- bridging factor 1) (MBF1).

MYCN_MOUSE
θ value	6.88961 (rank : 65)	NC score	0.058932 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

ZCPW1_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.044131 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

CREB3_MOUSE
θ value	8.99809 (rank : 67)	NC score	0.012039 (rank : 72)
Query Neighborhood Hits	70	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q61817, Q99M21, Q9CVK9	Gene names	Creb3, Lzip
Domain Architecture	No domain graphic available
Description	Cyclic AMP-responsive element-binding protein 3 (Transcription factor LZIP).

MAD4_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.105045 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	65	Shared Neighborhood Hits	24
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

NAC1_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.013934 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P32418, O95849, Q9UBL8, Q9UDN1, Q9UDN2, Q9UKX6	Gene names	SLC8A1, CNC, NCX1
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

PHLB1_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.015154 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	678	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

MAX_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.077321 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	35
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.077640 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	139	Shared Neighborhood Hits	35
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MITF_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.117714 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MYC_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.055454 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

TFEB_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.101227 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	111	Shared Neighborhood Hits	43
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.101771 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	119	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

Hits sorted by NC score

BHLH2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	70
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH2_HUMAN
NC score	0.992403 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	70	Target Neighborhood Hits	80	Shared Neighborhood Hits	57
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH3_MOUSE
NC score	0.935672 (rank : 3)	θ value	9.76566e-63 (rank : 3)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	50
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH3_HUMAN
NC score	0.926259 (rank : 4)	θ value	1.61343e-57 (rank : 4)
Query Neighborhood Hits	70	Target Neighborhood Hits	106	Shared Neighborhood Hits	50
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

HES4_HUMAN
NC score	0.597139 (rank : 5)	θ value	8.11959e-09 (rank : 5)
Query Neighborhood Hits	70	Target Neighborhood Hits	58	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_HUMAN
NC score	0.566630 (rank : 6)	θ value	5.26297e-08 (rank : 6)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	36
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
NC score	0.563815 (rank : 7)	θ value	5.26297e-08 (rank : 7)
Query Neighborhood Hits	70	Target Neighborhood Hits	78	Shared Neighborhood Hits	36
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES5_MOUSE
NC score	0.548708 (rank : 8)	θ value	0.00035302 (rank : 14)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	29
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HEY2_MOUSE
NC score	0.525737 (rank : 9)	θ value	2.88788e-06 (rank : 11)
Query Neighborhood Hits	70	Target Neighborhood Hits	80	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY2_HUMAN
NC score	0.519838 (rank : 10)	θ value	2.88788e-06 (rank : 10)
Query Neighborhood Hits	70	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY1_MOUSE
NC score	0.516869 (rank : 11)	θ value	2.88788e-06 (rank : 9)
Query Neighborhood Hits	70	Target Neighborhood Hits	69	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HES2_MOUSE
NC score	0.513980 (rank : 12)	θ value	7.1131e-05 (rank : 12)
Query Neighborhood Hits	70	Target Neighborhood Hits	36	Shared Neighborhood Hits	25
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HEY1_HUMAN
NC score	0.510443 (rank : 13)	θ value	2.88788e-06 (rank : 8)
Query Neighborhood Hits	70	Target Neighborhood Hits	82	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES2_HUMAN
NC score	0.508893 (rank : 14)	θ value	0.00035302 (rank : 13)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES3_MOUSE
NC score	0.467223 (rank : 15)	θ value	0.00390308 (rank : 18)
Query Neighborhood Hits	70	Target Neighborhood Hits	38	Shared Neighborhood Hits	24
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES6_HUMAN
NC score	0.458028 (rank : 16)	θ value	0.000602161 (rank : 16)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.440288 (rank : 17)	θ value	0.000786445 (rank : 17)
Query Neighborhood Hits	70	Target Neighborhood Hits	49	Shared Neighborhood Hits	23
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_MOUSE
NC score	0.417193 (rank : 18)	θ value	0.00035302 (rank : 15)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_HUMAN
NC score	0.394978 (rank : 19)	θ value	0.0330416 (rank : 20)
Query Neighborhood Hits	70	Target Neighborhood Hits	72	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

SRBP2_HUMAN
NC score	0.202030 (rank : 20)	θ value	0.0193708 (rank : 19)
Query Neighborhood Hits	70	Target Neighborhood Hits	133	Shared Neighborhood Hits	41
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

USF1_MOUSE
NC score	0.201137 (rank : 21)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	70	Target Neighborhood Hits	71	Shared Neighborhood Hits	43
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.200889 (rank : 22)	θ value	0.279714 (rank : 28)
Query Neighborhood Hits	70	Target Neighborhood Hits	70	Shared Neighborhood Hits	43
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MAD1_MOUSE
NC score	0.187960 (rank : 23)	θ value	0.0330416 (rank : 21)
Query Neighborhood Hits	70	Target Neighborhood Hits	75	Shared Neighborhood Hits	29
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SRBP1_HUMAN
NC score	0.187466 (rank : 24)	θ value	0.125558 (rank : 26)
Query Neighborhood Hits	70	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
NC score	0.184509 (rank : 25)	θ value	0.0563607 (rank : 22)
Query Neighborhood Hits	70	Target Neighborhood Hits	384	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAD1_HUMAN
NC score	0.179008 (rank : 26)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	70	Target Neighborhood Hits	68	Shared Neighborhood Hits	29
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MLX_MOUSE
NC score	0.176044 (rank : 27)	θ value	0.813845 (rank : 33)
Query Neighborhood Hits	70	Target Neighborhood Hits	100	Shared Neighborhood Hits	32
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.174464 (rank : 28)	θ value	1.06291 (rank : 35)
Query Neighborhood Hits	70	Target Neighborhood Hits	95	Shared Neighborhood Hits	32
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

USF2_MOUSE
NC score	0.170481 (rank : 29)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	70	Target Neighborhood Hits	173	Shared Neighborhood Hits	43
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

BMAL1_MOUSE
NC score	0.169481 (rank : 30)	θ value	0.0736092 (rank : 24)
Query Neighborhood Hits	70	Target Neighborhood Hits	121	Shared Neighborhood Hits	46
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.168582 (rank : 31)	θ value	0.0736092 (rank : 23)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	46
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

USF2_HUMAN
NC score	0.168124 (rank : 32)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	70	Target Neighborhood Hits	155	Shared Neighborhood Hits	42
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

MXI1_HUMAN
NC score	0.164104 (rank : 33)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	70	Target Neighborhood Hits	76	Shared Neighborhood Hits	28
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
NC score	0.162617 (rank : 34)	θ value	1.06291 (rank : 37)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	28
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD4_HUMAN
NC score	0.146579 (rank : 35)	θ value	0.813845 (rank : 32)
Query Neighborhood Hits	70	Target Neighborhood Hits	94	Shared Neighborhood Hits	35
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

TFE3_HUMAN
NC score	0.145124 (rank : 36)	θ value	2.36792 (rank : 51)
Query Neighborhood Hits	70	Target Neighborhood Hits	190	Shared Neighborhood Hits	44
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MAD3_HUMAN
NC score	0.139083 (rank : 37)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	70	Target Neighborhood Hits	92	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

ARNT2_MOUSE
NC score	0.126585 (rank : 38)	θ value	0.279714 (rank : 27)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	37
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

MITF_MOUSE
NC score	0.124687 (rank : 39)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	70	Target Neighborhood Hits	115	Shared Neighborhood Hits	47
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

ARNT_MOUSE
NC score	0.124367 (rank : 40)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	70	Target Neighborhood Hits	213	Shared Neighborhood Hits	39
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_HUMAN
NC score	0.121873 (rank : 41)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_HUMAN
NC score	0.120346 (rank : 42)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	70	Target Neighborhood Hits	109	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

MAD3_MOUSE
NC score	0.119760 (rank : 43)	θ value	2.36792 (rank : 50)
Query Neighborhood Hits	70	Target Neighborhood Hits	94	Shared Neighborhood Hits	25
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MITF_HUMAN
NC score	0.117714 (rank : 44)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	70	Target Neighborhood Hits	113	Shared Neighborhood Hits	46
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

CLOCK_HUMAN
NC score	0.110722 (rank : 45)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	70	Target Neighborhood Hits	127	Shared Neighborhood Hits	31
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

NPAS2_MOUSE
NC score	0.110622 (rank : 46)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	70	Target Neighborhood Hits	132	Shared Neighborhood Hits	30
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NPAS2_HUMAN
NC score	0.110609 (rank : 47)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	70	Target Neighborhood Hits	150	Shared Neighborhood Hits	29
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

CLOCK_MOUSE
NC score	0.107885 (rank : 48)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	70	Target Neighborhood Hits	148	Shared Neighborhood Hits	29
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MAD4_MOUSE
NC score	0.105045 (rank : 49)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	70	Target Neighborhood Hits	65	Shared Neighborhood Hits	24
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

TFEB_MOUSE
NC score	0.101771 (rank : 50)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	70	Target Neighborhood Hits	119	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.101227 (rank : 51)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	70	Target Neighborhood Hits	111	Shared Neighborhood Hits	43
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

CN048_HUMAN
NC score	0.098417 (rank : 52)	θ value	1.06291 (rank : 34)
Query Neighborhood Hits	70	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NCU1, Q8N7S1	Gene names	C14orf48
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf48.

MYCL1_MOUSE
NC score	0.092237 (rank : 53)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	70	Target Neighborhood Hits	123	Shared Neighborhood Hits	36
SwissProt Accessions	P10166, Q5FWI7	Gene names	Mycl1, Lmyc1, Mycl
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYCL1_HUMAN
NC score	0.089106 (rank : 54)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	70	Target Neighborhood Hits	146	Shared Neighborhood Hits	36
SwissProt Accessions	P12524, Q14897, Q5QPL0, Q5QPL1, Q9NUE9	Gene names	MYCL1, LMYC, MYCL
Domain Architecture
Description	L-myc-1 proto-oncogene protein.

MYC_HUMAN
NC score	0.085370 (rank : 55)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	70	Target Neighborhood Hits	146	Shared Neighborhood Hits	30
SwissProt Accessions	P01106, P01107, Q14026	Gene names	MYC
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

MAX_MOUSE
NC score	0.077640 (rank : 56)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	70	Target Neighborhood Hits	139	Shared Neighborhood Hits	35
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MAX_HUMAN
NC score	0.077321 (rank : 57)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	35
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MYCN_MOUSE
NC score	0.058932 (rank : 58)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	29
SwissProt Accessions	P03966, Q61978	Gene names	Mycn, Nmyc, Nmyc1
Domain Architecture
Description	N-myc proto-oncogene protein.

MYC_MOUSE
NC score	0.055454 (rank : 59)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	70	Target Neighborhood Hits	125	Shared Neighborhood Hits	26
SwissProt Accessions	P01108, P70247, Q3UM70, Q61422	Gene names	Myc
Domain Architecture
Description	Myc proto-oncogene protein (c-Myc) (Transcription factor p64).

ZCPW1_HUMAN
NC score	0.044131 (rank : 60)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	70	Target Neighborhood Hits	116	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

PHLB1_HUMAN
NC score	0.021485 (rank : 61)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	70	Target Neighborhood Hits	1038	Shared Neighborhood Hits	8
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

EDF1_MOUSE
NC score	0.019323 (rank : 62)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	70	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JMG1, Q99NE6	Gene names	Edf1
Domain Architecture	No domain graphic available
Description	Endothelial differentiation-related factor 1 (EDF-1) (Multiprotein- bridging factor 1) (MBF1).

CCD93_MOUSE
NC score	0.018822 (rank : 63)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	70	Target Neighborhood Hits	362	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TQK5, Q3TX53	Gene names	Ccdc93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

MEOX2_MOUSE
NC score	0.016831 (rank : 64)	θ value	1.81305 (rank : 45)
Query Neighborhood Hits	70	Target Neighborhood Hits	341	Shared Neighborhood Hits	4
SwissProt Accessions	P32443, Q544T6	Gene names	Meox2, Gax, Mox-2, Mox2
Domain Architecture
Description	Homeobox protein MOX-2 (Mesenchyme homeobox 2).

NAC1_MOUSE
NC score	0.015653 (rank : 65)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	70	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P70414	Gene names	Slc8a1, Ncx
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

PHLB1_MOUSE
NC score	0.015154 (rank : 66)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	70	Target Neighborhood Hits	678	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PTF1A_MOUSE
NC score	0.014146 (rank : 67)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	70	Target Neighborhood Hits	100	Shared Neighborhood Hits	8
SwissProt Accessions	Q9QX98, Q9QYF5, Q9QYF6	Gene names	Ptf1a, Ptf1p48
Domain Architecture	No domain graphic available
Description	Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA- binding subunit of transcription factor PTF1) (PTF1-p48).

PSB10_HUMAN
NC score	0.014027 (rank : 68)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	70	Target Neighborhood Hits	35	Shared Neighborhood Hits	2
SwissProt Accessions	P40306, Q5U098	Gene names	PSMB10, MECL1
Domain Architecture
Description	Proteasome subunit beta type 10 precursor (EC 3.4.25.1) (Proteasome MECl-1) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1).

NAC1_HUMAN
NC score	0.013934 (rank : 69)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	70	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	P32418, O95849, Q9UBL8, Q9UDN1, Q9UDN2, Q9UKX6	Gene names	SLC8A1, CNC, NCX1
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

MEOX2_HUMAN
NC score	0.013185 (rank : 70)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	70	Target Neighborhood Hits	340	Shared Neighborhood Hits	4
SwissProt Accessions	P50222, O75263, Q9UPL6	Gene names	MEOX2, GAX, MOX2
Domain Architecture
Description	Homeobox protein MOX-2 (Mesenchyme homeobox 2) (Growth arrest-specific homeobox).

CCD93_HUMAN
NC score	0.012868 (rank : 71)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	70	Target Neighborhood Hits	600	Shared Neighborhood Hits	5
SwissProt Accessions	Q567U6, Q4LE78, Q53TJ2, Q8TBX5, Q9H6R5, Q9NV15	Gene names	CCDC93
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 93.

CREB3_MOUSE
NC score	0.012039 (rank : 72)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	70	Target Neighborhood Hits	97	Shared Neighborhood Hits	3
SwissProt Accessions	Q61817, Q99M21, Q9CVK9	Gene names	Creb3, Lzip
Domain Architecture	No domain graphic available
Description	Cyclic AMP-responsive element-binding protein 3 (Transcription factor LZIP).

BACH2_MOUSE
NC score	0.007757 (rank : 73)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	70	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	P97303	Gene names	Bach2
Domain Architecture
Description	Transcription regulator protein BACH2 (BTB and CNC homolog 2).

CHD6_HUMAN
NC score	0.006689 (rank : 74)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	70	Target Neighborhood Hits	342	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TD26, Q5JYQ0, Q5TGZ9, Q5TH00, Q5TH01, Q8IZR2, Q8WTY0, Q9H4H6, Q9H6D4, Q9NTT7, Q9P2L1	Gene names	CHD6, CHD5, KIAA1335, RIGB
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 6 (EC 3.6.1.-) (ATP- dependent helicase CHD6) (CHD-6) (Radiation-induced gene B protein).

PRDM1_MOUSE
NC score	0.002419 (rank : 75)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	70	Target Neighborhood Hits	766	Shared Neighborhood Hits	3
SwissProt Accessions	Q60636	Gene names	Prdm1, Blimp1
Domain Architecture
Description	PR domain zinc finger protein 1 (PR domain-containing protein 1) (Beta-interferon gene positive-regulatory domain I-binding factor) (BLIMP-1).

REST_MOUSE
NC score	0.001711 (rank : 76)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	70	Target Neighborhood Hits	1506	Shared Neighborhood Hits	8
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.