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Network neighborhood for query Sequence : HES4_HUMAN

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HES4_HUMAN
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HES4_HUMAN
θ value	1.00825e-67 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_HUMAN
θ value	1.56274e-52 (rank : 2)	NC score	0.979292 (rank : 2)
Query Neighborhood Hits	58	Target Neighborhood Hits	76	Shared Neighborhood Hits	49
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	1.56274e-52 (rank : 3)	NC score	0.977661 (rank : 3)
Query Neighborhood Hits	58	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES2_MOUSE
θ value	4.43474e-23 (rank : 4)	NC score	0.925658 (rank : 4)
Query Neighborhood Hits	58	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
θ value	8.36355e-22 (rank : 5)	NC score	0.916258 (rank : 5)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HEY2_HUMAN
θ value	8.10077e-17 (rank : 6)	NC score	0.813659 (rank : 8)
Query Neighborhood Hits	58	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	8.10077e-17 (rank : 7)	NC score	0.813024 (rank : 9)
Query Neighborhood Hits	58	Target Neighborhood Hits	80	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HEY1_HUMAN
θ value	1.52774e-15 (rank : 8)	NC score	0.796417 (rank : 12)
Query Neighborhood Hits	58	Target Neighborhood Hits	82	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES6_HUMAN
θ value	9.90251e-15 (rank : 9)	NC score	0.818421 (rank : 7)
Query Neighborhood Hits	58	Target Neighborhood Hits	49	Shared Neighborhood Hits	27
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HEY1_MOUSE
θ value	9.90251e-15 (rank : 10)	NC score	0.798989 (rank : 11)
Query Neighborhood Hits	58	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HES6_MOUSE
θ value	2.88119e-14 (rank : 11)	NC score	0.809238 (rank : 10)
Query Neighborhood Hits	58	Target Neighborhood Hits	49	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES7_MOUSE
θ value	3.52202e-12 (rank : 12)	NC score	0.747464 (rank : 14)
Query Neighborhood Hits	58	Target Neighborhood Hits	72	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_HUMAN
θ value	6.00763e-12 (rank : 13)	NC score	0.750303 (rank : 13)
Query Neighborhood Hits	58	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES5_MOUSE
θ value	4.30538e-10 (rank : 14)	NC score	0.849466 (rank : 6)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

BHLH2_HUMAN
θ value	4.76016e-09 (rank : 15)	NC score	0.613807 (rank : 16)
Query Neighborhood Hits	58	Target Neighborhood Hits	80	Shared Neighborhood Hits	40
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH3_MOUSE
θ value	6.21693e-09 (rank : 16)	NC score	0.607797 (rank : 18)
Query Neighborhood Hits	58	Target Neighborhood Hits	70	Shared Neighborhood Hits	40
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH2_MOUSE
θ value	8.11959e-09 (rank : 17)	NC score	0.597139 (rank : 19)
Query Neighborhood Hits	58	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_HUMAN
θ value	8.97725e-08 (rank : 18)	NC score	0.609596 (rank : 17)
Query Neighborhood Hits	58	Target Neighborhood Hits	106	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

HES3_MOUSE
θ value	1.17247e-07 (rank : 19)	NC score	0.714274 (rank : 15)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

MITF_HUMAN
θ value	0.0736092 (rank : 20)	NC score	0.213779 (rank : 21)
Query Neighborhood Hits	58	Target Neighborhood Hits	113	Shared Neighborhood Hits	39
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	0.0736092 (rank : 21)	NC score	0.209548 (rank : 22)
Query Neighborhood Hits	58	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TFE3_HUMAN
θ value	0.0736092 (rank : 22)	NC score	0.214406 (rank : 20)
Query Neighborhood Hits	58	Target Neighborhood Hits	190	Shared Neighborhood Hits	34
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MAD1_MOUSE
θ value	0.163984 (rank : 23)	NC score	0.133884 (rank : 35)
Query Neighborhood Hits	58	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

SRBP1_HUMAN
θ value	0.163984 (rank : 24)	NC score	0.176583 (rank : 29)
Query Neighborhood Hits	58	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SSBP4_HUMAN
θ value	0.279714 (rank : 25)	NC score	0.028407 (rank : 64)
Query Neighborhood Hits	58	Target Neighborhood Hits	753	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

BMAL1_HUMAN
θ value	0.365318 (rank : 26)	NC score	0.153142 (rank : 33)
Query Neighborhood Hits	58	Target Neighborhood Hits	115	Shared Neighborhood Hits	40
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	0.365318 (rank : 27)	NC score	0.155603 (rank : 32)
Query Neighborhood Hits	58	Target Neighborhood Hits	121	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

USF2_HUMAN
θ value	0.47712 (rank : 28)	NC score	0.180311 (rank : 27)
Query Neighborhood Hits	58	Target Neighborhood Hits	155	Shared Neighborhood Hits	33
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	0.47712 (rank : 29)	NC score	0.183238 (rank : 26)
Query Neighborhood Hits	58	Target Neighborhood Hits	173	Shared Neighborhood Hits	34
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

NCOA6_MOUSE
θ value	0.62314 (rank : 30)	NC score	0.025132 (rank : 65)
Query Neighborhood Hits	58	Target Neighborhood Hits	1076	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SRBP2_HUMAN
θ value	0.813845 (rank : 31)	NC score	0.186360 (rank : 25)
Query Neighborhood Hits	58	Target Neighborhood Hits	133	Shared Neighborhood Hits	39
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

ARNT_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.098277 (rank : 40)
Query Neighborhood Hits	58	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	1.38821 (rank : 33)	NC score	0.098514 (rank : 39)
Query Neighborhood Hits	58	Target Neighborhood Hits	213	Shared Neighborhood Hits	33
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

MAD4_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.117909 (rank : 37)
Query Neighborhood Hits	58	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

SRBP1_MOUSE
θ value	1.38821 (rank : 35)	NC score	0.158414 (rank : 31)
Query Neighborhood Hits	58	Target Neighborhood Hits	384	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

NCOA1_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.072986 (rank : 51)
Query Neighborhood Hits	58	Target Neighborhood Hits	198	Shared Neighborhood Hits	23
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	1.81305 (rank : 37)	NC score	0.072869 (rank : 52)
Query Neighborhood Hits	58	Target Neighborhood Hits	196	Shared Neighborhood Hits	21
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

MAD1_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.112237 (rank : 38)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	25
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

USF1_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.190833 (rank : 24)
Query Neighborhood Hits	58	Target Neighborhood Hits	70	Shared Neighborhood Hits	34
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	2.36792 (rank : 40)	NC score	0.190910 (rank : 23)
Query Neighborhood Hits	58	Target Neighborhood Hits	71	Shared Neighborhood Hits	34
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

MYF6_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.071754 (rank : 55)
Query Neighborhood Hits	58	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
θ value	3.0926 (rank : 42)	NC score	0.071247 (rank : 56)
Query Neighborhood Hits	58	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

RB6I2_HUMAN
θ value	3.0926 (rank : 43)	NC score	0.004350 (rank : 69)
Query Neighborhood Hits	58	Target Neighborhood Hits	1584	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

TFEB_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.176159 (rank : 30)
Query Neighborhood Hits	58	Target Neighborhood Hits	111	Shared Neighborhood Hits	32
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.178321 (rank : 28)
Query Neighborhood Hits	58	Target Neighborhood Hits	119	Shared Neighborhood Hits	33
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

RB6I2_MOUSE
θ value	4.03905 (rank : 46)	NC score	0.008170 (rank : 67)
Query Neighborhood Hits	58	Target Neighborhood Hits	1433	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

MAD4_MOUSE
θ value	5.27518 (rank : 47)	NC score	0.086891 (rank : 44)
Query Neighborhood Hits	58	Target Neighborhood Hits	65	Shared Neighborhood Hits	16
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MYF5_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.050235 (rank : 62)
Query Neighborhood Hits	58	Target Neighborhood Hits	80	Shared Neighborhood Hits	11
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYF5_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.049871 (rank : 63)
Query Neighborhood Hits	58	Target Neighborhood Hits	77	Shared Neighborhood Hits	11
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYOD1_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.081039 (rank : 47)
Query Neighborhood Hits	58	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOD1_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.081722 (rank : 46)
Query Neighborhood Hits	58	Target Neighborhood Hits	82	Shared Neighborhood Hits	14
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

CO1A2_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.004479 (rank : 68)
Query Neighborhood Hits	58	Target Neighborhood Hits	388	Shared Neighborhood Hits	4
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

MY18A_MOUSE
θ value	6.88961 (rank : 53)	NC score	-0.000456 (rank : 70)
Query Neighborhood Hits	58	Target Neighborhood Hits	1989	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYOG_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.076367 (rank : 48)
Query Neighborhood Hits	58	Target Neighborhood Hits	67	Shared Neighborhood Hits	16
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.075920 (rank : 49)
Query Neighborhood Hits	58	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

ARNT2_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.094545 (rank : 42)
Query Neighborhood Hits	58	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	8.99809 (rank : 57)	NC score	0.096194 (rank : 41)
Query Neighborhood Hits	58	Target Neighborhood Hits	115	Shared Neighborhood Hits	31
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

MMAC_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.012169 (rank : 66)
Query Neighborhood Hits	58	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y4U1, Q5T157, Q9BRQ7	Gene names	MMACHC
Domain Architecture	No domain graphic available
Description	Methylmalonic aciduria and homocystinuria type C protein.

CLOCK_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.068688 (rank : 57)
Query Neighborhood Hits	58	Target Neighborhood Hits	127	Shared Neighborhood Hits	28
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.067138 (rank : 58)
Query Neighborhood Hits	58	Target Neighborhood Hits	148	Shared Neighborhood Hits	27
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MAD3_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.072754 (rank : 53)
Query Neighborhood Hits	58	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAD3_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.058355 (rank : 59)
Query Neighborhood Hits	58	Target Neighborhood Hits	94	Shared Neighborhood Hits	21
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

MAX_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.071967 (rank : 54)
Query Neighborhood Hits	58	Target Neighborhood Hits	125	Shared Neighborhood Hits	30
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MAX_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.073893 (rank : 50)
Query Neighborhood Hits	58	Target Neighborhood Hits	139	Shared Neighborhood Hits	31
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

MLX_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.133155 (rank : 36)
Query Neighborhood Hits	58	Target Neighborhood Hits	95	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.135424 (rank : 34)
Query Neighborhood Hits	58	Target Neighborhood Hits	100	Shared Neighborhood Hits	31
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MXI1_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.087532 (rank : 43)
Query Neighborhood Hits	58	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MXI1_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.086741 (rank : 45)
Query Neighborhood Hits	58	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

NPAS2_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.055530 (rank : 60)
Query Neighborhood Hits	58	Target Neighborhood Hits	150	Shared Neighborhood Hits	27
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.055333 (rank : 61)
Query Neighborhood Hits	58	Target Neighborhood Hits	132	Shared Neighborhood Hits	28
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

Hits sorted by NC score

HES4_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.00825e-67 (rank : 1)
Query Neighborhood Hits	58	Target Neighborhood Hits	58	Shared Neighborhood Hits	58
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES1_HUMAN
NC score	0.979292 (rank : 2)	θ value	1.56274e-52 (rank : 2)
Query Neighborhood Hits	58	Target Neighborhood Hits	76	Shared Neighborhood Hits	49
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
NC score	0.977661 (rank : 3)	θ value	1.56274e-52 (rank : 3)
Query Neighborhood Hits	58	Target Neighborhood Hits	78	Shared Neighborhood Hits	48
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES2_MOUSE
NC score	0.925658 (rank : 4)	θ value	4.43474e-23 (rank : 4)
Query Neighborhood Hits	58	Target Neighborhood Hits	36	Shared Neighborhood Hits	28
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES2_HUMAN
NC score	0.916258 (rank : 5)	θ value	8.36355e-22 (rank : 5)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES5_MOUSE
NC score	0.849466 (rank : 6)	θ value	4.30538e-10 (rank : 14)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES6_HUMAN
NC score	0.818421 (rank : 7)	θ value	9.90251e-15 (rank : 9)
Query Neighborhood Hits	58	Target Neighborhood Hits	49	Shared Neighborhood Hits	27
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HEY2_HUMAN
NC score	0.813659 (rank : 8)	θ value	8.10077e-17 (rank : 6)
Query Neighborhood Hits	58	Target Neighborhood Hits	77	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.813024 (rank : 9)	θ value	8.10077e-17 (rank : 7)
Query Neighborhood Hits	58	Target Neighborhood Hits	80	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HES6_MOUSE
NC score	0.809238 (rank : 10)	θ value	2.88119e-14 (rank : 11)
Query Neighborhood Hits	58	Target Neighborhood Hits	49	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HEY1_MOUSE
NC score	0.798989 (rank : 11)	θ value	9.90251e-15 (rank : 10)
Query Neighborhood Hits	58	Target Neighborhood Hits	69	Shared Neighborhood Hits	39
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY1_HUMAN
NC score	0.796417 (rank : 12)	θ value	1.52774e-15 (rank : 8)
Query Neighborhood Hits	58	Target Neighborhood Hits	82	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES7_HUMAN
NC score	0.750303 (rank : 13)	θ value	6.00763e-12 (rank : 13)
Query Neighborhood Hits	58	Target Neighborhood Hits	72	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_MOUSE
NC score	0.747464 (rank : 14)	θ value	3.52202e-12 (rank : 12)
Query Neighborhood Hits	58	Target Neighborhood Hits	72	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES3_MOUSE
NC score	0.714274 (rank : 15)	θ value	1.17247e-07 (rank : 19)
Query Neighborhood Hits	58	Target Neighborhood Hits	38	Shared Neighborhood Hits	22
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

BHLH2_HUMAN
NC score	0.613807 (rank : 16)	θ value	4.76016e-09 (rank : 15)
Query Neighborhood Hits	58	Target Neighborhood Hits	80	Shared Neighborhood Hits	40
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH3_HUMAN
NC score	0.609596 (rank : 17)	θ value	8.97725e-08 (rank : 18)
Query Neighborhood Hits	58	Target Neighborhood Hits	106	Shared Neighborhood Hits	41
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.607797 (rank : 18)	θ value	6.21693e-09 (rank : 16)
Query Neighborhood Hits	58	Target Neighborhood Hits	70	Shared Neighborhood Hits	40
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BHLH2_MOUSE
NC score	0.597139 (rank : 19)	θ value	8.11959e-09 (rank : 17)
Query Neighborhood Hits	58	Target Neighborhood Hits	70	Shared Neighborhood Hits	38
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

TFE3_HUMAN
NC score	0.214406 (rank : 20)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	58	Target Neighborhood Hits	190	Shared Neighborhood Hits	34
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

MITF_HUMAN
NC score	0.213779 (rank : 21)	θ value	0.0736092 (rank : 20)
Query Neighborhood Hits	58	Target Neighborhood Hits	113	Shared Neighborhood Hits	39
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.209548 (rank : 22)	θ value	0.0736092 (rank : 21)
Query Neighborhood Hits	58	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

USF1_MOUSE
NC score	0.190910 (rank : 23)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	58	Target Neighborhood Hits	71	Shared Neighborhood Hits	34
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_HUMAN
NC score	0.190833 (rank : 24)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	58	Target Neighborhood Hits	70	Shared Neighborhood Hits	34
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

SRBP2_HUMAN
NC score	0.186360 (rank : 25)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	58	Target Neighborhood Hits	133	Shared Neighborhood Hits	39
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

USF2_MOUSE
NC score	0.183238 (rank : 26)	θ value	0.47712 (rank : 29)
Query Neighborhood Hits	58	Target Neighborhood Hits	173	Shared Neighborhood Hits	34
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
NC score	0.180311 (rank : 27)	θ value	0.47712 (rank : 28)
Query Neighborhood Hits	58	Target Neighborhood Hits	155	Shared Neighborhood Hits	33
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

TFEB_MOUSE
NC score	0.178321 (rank : 28)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	58	Target Neighborhood Hits	119	Shared Neighborhood Hits	33
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

SRBP1_HUMAN
NC score	0.176583 (rank : 29)	θ value	0.163984 (rank : 24)
Query Neighborhood Hits	58	Target Neighborhood Hits	225	Shared Neighborhood Hits	38
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TFEB_HUMAN
NC score	0.176159 (rank : 30)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	58	Target Neighborhood Hits	111	Shared Neighborhood Hits	32
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

SRBP1_MOUSE
NC score	0.158414 (rank : 31)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	58	Target Neighborhood Hits	384	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

BMAL1_MOUSE
NC score	0.155603 (rank : 32)	θ value	0.365318 (rank : 27)
Query Neighborhood Hits	58	Target Neighborhood Hits	121	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.153142 (rank : 33)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	58	Target Neighborhood Hits	115	Shared Neighborhood Hits	40
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

MLX_MOUSE
NC score	0.135424 (rank : 34)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	58	Target Neighborhood Hits	100	Shared Neighborhood Hits	31
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MAD1_MOUSE
NC score	0.133884 (rank : 35)	θ value	0.163984 (rank : 23)
Query Neighborhood Hits	58	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	P50538, Q60798, Q61825	Gene names	Mxd1, Mad, Mad1
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

MLX_HUMAN
NC score	0.133155 (rank : 36)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	58	Target Neighborhood Hits	95	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MAD4_HUMAN
NC score	0.117909 (rank : 37)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	58	Target Neighborhood Hits	94	Shared Neighborhood Hits	30
SwissProt Accessions	Q14582, Q5TZX4	Gene names	MXD4, MAD4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MAD1_HUMAN
NC score	0.112237 (rank : 38)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	58	Target Neighborhood Hits	68	Shared Neighborhood Hits	25
SwissProt Accessions	Q05195	Gene names	MXD1, MAD
Domain Architecture
Description	MAD protein (MAX dimerizer) (MAX dimerization protein 1).

ARNT_MOUSE
NC score	0.098514 (rank : 39)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	58	Target Neighborhood Hits	213	Shared Neighborhood Hits	33
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_HUMAN
NC score	0.098277 (rank : 40)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	58	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_MOUSE
NC score	0.096194 (rank : 41)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	58	Target Neighborhood Hits	115	Shared Neighborhood Hits	31
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_HUMAN
NC score	0.094545 (rank : 42)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	58	Target Neighborhood Hits	109	Shared Neighborhood Hits	31
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

MXI1_HUMAN
NC score	0.087532 (rank : 43)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	58	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	P50539, Q15887	Gene names	MXI1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MAD4_MOUSE
NC score	0.086891 (rank : 44)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	58	Target Neighborhood Hits	65	Shared Neighborhood Hits	16
SwissProt Accessions	Q60948	Gene names	Mxd4, Mad4
Domain Architecture
Description	Max-interacting transcriptional repressor MAD4 (Max-associated protein 4) (MAX dimerization protein 4).

MXI1_MOUSE
NC score	0.086741 (rank : 45)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	58	Target Neighborhood Hits	109	Shared Neighborhood Hits	25
SwissProt Accessions	P50540	Gene names	Mxi1
Domain Architecture
Description	MAX-interacting protein 1 (Protein MXI1).

MYOD1_MOUSE
NC score	0.081722 (rank : 46)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	58	Target Neighborhood Hits	82	Shared Neighborhood Hits	14
SwissProt Accessions	P10085	Gene names	Myod1, Myod
Domain Architecture
Description	Myoblast determination protein 1.

MYOD1_HUMAN
NC score	0.081039 (rank : 47)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	58	Target Neighborhood Hits	100	Shared Neighborhood Hits	14
SwissProt Accessions	P15172	Gene names	MYOD1, MYF3, MYOD
Domain Architecture
Description	Myoblast determination protein 1 (Myogenic factor 3) (Myf-3).

MYOG_HUMAN
NC score	0.076367 (rank : 48)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	58	Target Neighborhood Hits	67	Shared Neighborhood Hits	16
SwissProt Accessions	P15173	Gene names	MYOG, MYF4
Domain Architecture
Description	Myogenin (Myogenic factor 4) (Myf-4).

MYOG_MOUSE
NC score	0.075920 (rank : 49)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	58	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	P12979	Gene names	Myog
Domain Architecture
Description	Myogenin (MYOD1-related protein).

MAX_MOUSE
NC score	0.073893 (rank : 50)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	58	Target Neighborhood Hits	139	Shared Neighborhood Hits	31
SwissProt Accessions	P28574	Gene names	Max, Myn
Domain Architecture
Description	Protein max (Myc-associated factor X) (Protein myn) (Myc-binding novel HLH/LZ protein).

NCOA1_HUMAN
NC score	0.072986 (rank : 51)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	58	Target Neighborhood Hits	198	Shared Neighborhood Hits	23
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
NC score	0.072869 (rank : 52)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	58	Target Neighborhood Hits	196	Shared Neighborhood Hits	21
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

MAD3_HUMAN
NC score	0.072754 (rank : 53)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	58	Target Neighborhood Hits	92	Shared Neighborhood Hits	27
SwissProt Accessions	Q9BW11, Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3	Gene names	MXD3, MAD3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3) (Myx).

MAX_HUMAN
NC score	0.071967 (rank : 54)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	58	Target Neighborhood Hits	125	Shared Neighborhood Hits	30
SwissProt Accessions	P61244, P25912, P52163	Gene names	MAX
Domain Architecture
Description	Protein max (Myc-associated factor X).

MYF6_HUMAN
NC score	0.071754 (rank : 55)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	58	Target Neighborhood Hits	74	Shared Neighborhood Hits	16
SwissProt Accessions	P23409, Q53X80, Q6FHI9	Gene names	MYF6
Domain Architecture
Description	Myogenic factor 6 (Myf-6).

MYF6_MOUSE
NC score	0.071247 (rank : 56)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	58	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	P15375	Gene names	Myf6, Myf-6
Domain Architecture
Description	Myogenic factor 6 (Myf-6) (Herculin).

CLOCK_HUMAN
NC score	0.068688 (rank : 57)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	58	Target Neighborhood Hits	127	Shared Neighborhood Hits	28
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

CLOCK_MOUSE
NC score	0.067138 (rank : 58)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	58	Target Neighborhood Hits	148	Shared Neighborhood Hits	27
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MAD3_MOUSE
NC score	0.058355 (rank : 59)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	58	Target Neighborhood Hits	94	Shared Neighborhood Hits	21
SwissProt Accessions	Q80US8, Q60947	Gene names	Mxd3, Mad3
Domain Architecture	No domain graphic available
Description	Max-interacting transcriptional repressor MAD3 (Max-associated protein 3) (MAX dimerization protein 3).

NPAS2_HUMAN
NC score	0.055530 (rank : 60)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	58	Target Neighborhood Hits	150	Shared Neighborhood Hits	27
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
NC score	0.055333 (rank : 61)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	58	Target Neighborhood Hits	132	Shared Neighborhood Hits	28
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

MYF5_HUMAN
NC score	0.050235 (rank : 62)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	58	Target Neighborhood Hits	80	Shared Neighborhood Hits	11
SwissProt Accessions	P13349	Gene names	MYF5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

MYF5_MOUSE
NC score	0.049871 (rank : 63)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	58	Target Neighborhood Hits	77	Shared Neighborhood Hits	11
SwissProt Accessions	P24699, Q543W7	Gene names	Myf5, Myf-5
Domain Architecture
Description	Myogenic factor 5 (Myf-5).

SSBP4_HUMAN
NC score	0.028407 (rank : 64)	θ value	0.279714 (rank : 25)
Query Neighborhood Hits	58	Target Neighborhood Hits	753	Shared Neighborhood Hits	10
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

NCOA6_MOUSE
NC score	0.025132 (rank : 65)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	58	Target Neighborhood Hits	1076	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

MMAC_HUMAN
NC score	0.012169 (rank : 66)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	58	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Y4U1, Q5T157, Q9BRQ7	Gene names	MMACHC
Domain Architecture	No domain graphic available
Description	Methylmalonic aciduria and homocystinuria type C protein.

RB6I2_MOUSE
NC score	0.008170 (rank : 67)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	58	Target Neighborhood Hits	1433	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MI1, Q80TK7, Q8BPL1, Q8C7Y1, Q99MI2	Gene names	Erc1, Cast2, Kiaa1081, Rab6ip2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1) (ERC1) (CAZ-associated structural protein 2) (CAST2).

CO1A2_MOUSE
NC score	0.004479 (rank : 68)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	58	Target Neighborhood Hits	388	Shared Neighborhood Hits	4
SwissProt Accessions	Q01149, Q8CGA5	Gene names	Col1a2, Cola2
Domain Architecture
Description	Collagen alpha-2(I) chain precursor.

RB6I2_HUMAN
NC score	0.004350 (rank : 69)	θ value	3.0926 (rank : 43)
Query Neighborhood Hits	58	Target Neighborhood Hits	1584	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

MY18A_MOUSE
NC score	-0.000456 (rank : 70)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	58	Target Neighborhood Hits	1989	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).