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Network neighborhood for query Sequence : HES7_MOUSE

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HES7_MOUSE
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HES7_MOUSE
θ value	9.035e-101 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_HUMAN
θ value	2.08775e-89 (rank : 2)	NC score	0.981917 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES4_HUMAN
θ value	3.52202e-12 (rank : 3)	NC score	0.747464 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES2_MOUSE
θ value	6.64225e-11 (rank : 4)	NC score	0.759426 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES5_MOUSE
θ value	8.67504e-11 (rank : 5)	NC score	0.772129 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES1_HUMAN
θ value	2.52405e-10 (rank : 6)	NC score	0.701169 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
θ value	2.52405e-10 (rank : 7)	NC score	0.701064 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES2_HUMAN
θ value	3.64472e-09 (rank : 8)	NC score	0.739017 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HEY1_HUMAN
θ value	3.41135e-07 (rank : 9)	NC score	0.594307 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	82	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HES6_MOUSE
θ value	1.69304e-06 (rank : 10)	NC score	0.631795 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HES6_HUMAN
θ value	2.21117e-06 (rank : 11)	NC score	0.633060 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	23
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HEY1_MOUSE
θ value	2.21117e-06 (rank : 12)	NC score	0.591632 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	69	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
θ value	4.92598e-06 (rank : 13)	NC score	0.584949 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
θ value	4.92598e-06 (rank : 14)	NC score	0.584886 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

HES3_MOUSE
θ value	8.40245e-06 (rank : 15)	NC score	0.634729 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

BHLH2_HUMAN
θ value	0.000121331 (rank : 16)	NC score	0.437821 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
θ value	0.00035302 (rank : 17)	NC score	0.417193 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_HUMAN
θ value	0.21417 (rank : 18)	NC score	0.386499 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	106	Shared Neighborhood Hits	29
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
θ value	0.21417 (rank : 19)	NC score	0.385187 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	28
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

SPR1B_MOUSE
θ value	0.279714 (rank : 20)	NC score	0.055923 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	395	Shared Neighborhood Hits	10
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

NPAS2_HUMAN
θ value	0.365318 (rank : 21)	NC score	0.092084 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

NPAS2_MOUSE
θ value	0.365318 (rank : 22)	NC score	0.092848 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	132	Shared Neighborhood Hits	25
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

PCLO_MOUSE
θ value	0.365318 (rank : 23)	NC score	0.032349 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	2275	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

TREF1_MOUSE
θ value	0.47712 (rank : 24)	NC score	0.034346 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	682	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

ZN385_HUMAN
θ value	0.47712 (rank : 25)	NC score	0.052755 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	614	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

CEL_HUMAN
θ value	0.62314 (rank : 26)	NC score	0.032594 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	896	Shared Neighborhood Hits	22
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

LIMD1_HUMAN
θ value	0.62314 (rank : 27)	NC score	0.028779 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

NCOA1_HUMAN
θ value	0.62314 (rank : 28)	NC score	0.092223 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	198	Shared Neighborhood Hits	23
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NCOA1_MOUSE
θ value	0.62314 (rank : 29)	NC score	0.092669 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	196	Shared Neighborhood Hits	25
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

SON_HUMAN
θ value	0.813845 (rank : 30)	NC score	0.035338 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	1568	Shared Neighborhood Hits	35
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

MEF2B_MOUSE
θ value	1.06291 (rank : 31)	NC score	0.032671 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

MUCDL_HUMAN
θ value	1.38821 (rank : 32)	NC score	0.026887 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	777	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SCAP_HUMAN
θ value	1.38821 (rank : 33)	NC score	0.026074 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	368	Shared Neighborhood Hits	4
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

ZAR1_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.040381 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

DDR1_HUMAN
θ value	1.81305 (rank : 35)	NC score	0.006269 (rank : 80)
Query Neighborhood Hits	72	Target Neighborhood Hits	819	Shared Neighborhood Hits	6
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

TNR1A_HUMAN
θ value	1.81305 (rank : 36)	NC score	0.025369 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

BMAL1_HUMAN
θ value	2.36792 (rank : 37)	NC score	0.113528 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	30
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

BMAL1_MOUSE
θ value	2.36792 (rank : 38)	NC score	0.114988 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	121	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

DDR1_MOUSE
θ value	2.36792 (rank : 39)	NC score	0.006007 (rank : 81)
Query Neighborhood Hits	72	Target Neighborhood Hits	818	Shared Neighborhood Hits	6
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

K1543_MOUSE
θ value	2.36792 (rank : 40)	NC score	0.031126 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	497	Shared Neighborhood Hits	14
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

MINT_MOUSE
θ value	3.0926 (rank : 41)	NC score	0.019949 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	1514	Shared Neighborhood Hits	21
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

LATS2_HUMAN
θ value	4.03905 (rank : 42)	NC score	0.001695 (rank : 86)
Query Neighborhood Hits	72	Target Neighborhood Hits	884	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

MITF_HUMAN
θ value	4.03905 (rank : 43)	NC score	0.106530 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	113	Shared Neighborhood Hits	27
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
θ value	4.03905 (rank : 44)	NC score	0.103756 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	27
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TM108_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.028706 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	336	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

HXA2_HUMAN
θ value	5.27518 (rank : 46)	NC score	0.003973 (rank : 84)
Query Neighborhood Hits	72	Target Neighborhood Hits	370	Shared Neighborhood Hits	2
SwissProt Accessions	O43364	Gene names	HOXA2
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-A2.

LCP2_HUMAN
θ value	5.27518 (rank : 47)	NC score	0.020534 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	531	Shared Neighborhood Hits	14
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

TAU_MOUSE
θ value	5.27518 (rank : 48)	NC score	0.018160 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	502	Shared Neighborhood Hits	12
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TCGAP_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.013470 (rank : 77)
Query Neighborhood Hits	72	Target Neighborhood Hits	409	Shared Neighborhood Hits	13
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

AHR_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.052024 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	15
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

CAC1G_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.010776 (rank : 79)
Query Neighborhood Hits	72	Target Neighborhood Hits	587	Shared Neighborhood Hits	12
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

E2AK4_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.001794 (rank : 85)
Query Neighborhood Hits	72	Target Neighborhood Hits	984	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

ELL_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.016048 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	183	Shared Neighborhood Hits	5
SwissProt Accessions	P55199	Gene names	ELL, C19orf17
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

FXL19_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.018478 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	147	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

RGS3_MOUSE
θ value	6.88961 (rank : 55)	NC score	0.018285 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	1621	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SCO1_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.023118 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	O75880	Gene names	SCO1, SCOD1
Domain Architecture
Description	SCO1 protein homolog, mitochondrial precursor.

SYNP2_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.013851 (rank : 75)
Query Neighborhood Hits	72	Target Neighborhood Hits	323	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

UB7I1_MOUSE
θ value	6.88961 (rank : 58)	NC score	0.017971 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

ZFPL1_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.020614 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	O95159, O14616, Q9UID0	Gene names	ZFPL1
Domain Architecture	No domain graphic available
Description	Zinc finger protein-like 1 (Zinc finger protein MCG4).

ABCA7_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.004700 (rank : 83)
Query Neighborhood Hits	72	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

AMOL2_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.004728 (rank : 82)
Query Neighborhood Hits	72	Target Neighborhood Hits	591	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

CLOCK_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.079596 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	127	Shared Neighborhood Hits	25
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

EGR4_HUMAN
θ value	8.99809 (rank : 63)	NC score	-0.000063 (rank : 87)
Query Neighborhood Hits	72	Target Neighborhood Hits	939	Shared Neighborhood Hits	8
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).

ERCC2_MOUSE
θ value	8.99809 (rank : 64)	NC score	0.015841 (rank : 73)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O08811, Q9DC01	Gene names	Ercc2, Xpd
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

FXL19_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.016489 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

K1802_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.013498 (rank : 76)
Query Neighborhood Hits	72	Target Neighborhood Hits	1378	Shared Neighborhood Hits	22
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

MLL3_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.016059 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	1644	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NCOA3_HUMAN
θ value	8.99809 (rank : 68)	NC score	0.049249 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	171	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

RTN1_MOUSE
θ value	8.99809 (rank : 69)	NC score	0.012555 (rank : 78)
Query Neighborhood Hits	72	Target Neighborhood Hits	189	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

SAPS1_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.015111 (rank : 74)
Query Neighborhood Hits	72	Target Neighborhood Hits	704	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

TFEB_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.083016 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

TFEB_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.083238 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	119	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

ARNT2_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.059284 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT2_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.060670 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.060068 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.059454 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	213	Shared Neighborhood Hits	24
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

CLOCK_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.073398 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	148	Shared Neighborhood Hits	24
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

MLX_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.075215 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	95	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.076462 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	100	Shared Neighborhood Hits	19
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

SRBP1_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.068454 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	225	Shared Neighborhood Hits	27
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP1_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.062802 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	384	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.067252 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	133	Shared Neighborhood Hits	20
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

TFE3_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.088653 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

USF1_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.070422 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	20
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.070391 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	71	Shared Neighborhood Hits	20
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF2_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.062926 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	155	Shared Neighborhood Hits	19
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

USF2_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.066963 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	173	Shared Neighborhood Hits	21
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

Hits sorted by NC score

HES7_MOUSE
NC score	0.999962 (rank : 1)	θ value	9.035e-101 (rank : 1)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES7_HUMAN
NC score	0.981917 (rank : 2)	θ value	2.08775e-89 (rank : 2)
Query Neighborhood Hits	72	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	Q9BYE0	Gene names	HES7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

HES5_MOUSE
NC score	0.772129 (rank : 3)	θ value	8.67504e-11 (rank : 5)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	25
SwissProt Accessions	P70120, Q8BVI1	Gene names	Hes5, Hes-5
Domain Architecture
Description	Transcription factor HES-5 (Hairy and enhancer of split 5).

HES2_MOUSE
NC score	0.759426 (rank : 4)	θ value	6.64225e-11 (rank : 4)
Query Neighborhood Hits	72	Target Neighborhood Hits	36	Shared Neighborhood Hits	21
SwissProt Accessions	O54792	Gene names	Hes2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES4_HUMAN
NC score	0.747464 (rank : 5)	θ value	3.52202e-12 (rank : 3)
Query Neighborhood Hits	72	Target Neighborhood Hits	58	Shared Neighborhood Hits	27
SwissProt Accessions	Q9HCC6	Gene names	HES4
Domain Architecture
Description	Transcription factor HES-4 (Hairy and enhancer of split 4) (bHLH factor Hes4).

HES2_HUMAN
NC score	0.739017 (rank : 6)	θ value	3.64472e-09 (rank : 8)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q9Y543, Q96EN4, Q9Y542	Gene names	HES2
Domain Architecture
Description	Transcription factor HES-2 (Hairy and enhancer of split 2).

HES1_HUMAN
NC score	0.701169 (rank : 7)	θ value	2.52405e-10 (rank : 6)
Query Neighborhood Hits	72	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q14469	Gene names	HES1, HL, HRY
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1) (Hairy- like) (HHL) (Hairy homolog).

HES1_MOUSE
NC score	0.701064 (rank : 8)	θ value	2.52405e-10 (rank : 7)
Query Neighborhood Hits	72	Target Neighborhood Hits	78	Shared Neighborhood Hits	29
SwissProt Accessions	P35428	Gene names	Hes1, Hes-1
Domain Architecture
Description	Transcription factor HES-1 (Hairy and enhancer of split 1).

HES3_MOUSE
NC score	0.634729 (rank : 9)	θ value	8.40245e-06 (rank : 15)
Query Neighborhood Hits	72	Target Neighborhood Hits	38	Shared Neighborhood Hits	23
SwissProt Accessions	Q61657, O09083, O09150	Gene names	Hes3, Hes-3
Domain Architecture
Description	Transcription factor HES-3 (Hairy and enhancer of split 3).

HES6_HUMAN
NC score	0.633060 (rank : 10)	θ value	2.21117e-06 (rank : 11)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	23
SwissProt Accessions	Q96HZ4, Q8N2J2, Q96T93, Q9P2S3	Gene names	HES6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6) (C- HAIRY1).

HES6_MOUSE
NC score	0.631795 (rank : 11)	θ value	1.69304e-06 (rank : 10)
Query Neighborhood Hits	72	Target Neighborhood Hits	49	Shared Neighborhood Hits	21
SwissProt Accessions	Q9JHE6, Q3U2D7	Gene names	Hes6
Domain Architecture	No domain graphic available
Description	Transcription cofactor HES-6 (Hairy and enhancer of split 6).

HEY1_HUMAN
NC score	0.594307 (rank : 12)	θ value	3.41135e-07 (rank : 9)
Query Neighborhood Hits	72	Target Neighborhood Hits	82	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Y5J3, Q5TZS3, Q9NYP4	Gene names	HEY1, CHF2, HESR1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1) (Cardiovascular helix-loop-helix factor 2) (HES-related repressor protein 2) (HERP2).

HEY1_MOUSE
NC score	0.591632 (rank : 13)	θ value	2.21117e-06 (rank : 12)
Query Neighborhood Hits	72	Target Neighborhood Hits	69	Shared Neighborhood Hits	31
SwissProt Accessions	Q9WV93	Gene names	Hey1, Hesr1
Domain Architecture
Description	Hairy/enhancer-of-split related with YRPW motif 1 (Hairy and enhancer of split-related protein 1) (HESR-1).

HEY2_HUMAN
NC score	0.584949 (rank : 14)	θ value	4.92598e-06 (rank : 13)
Query Neighborhood Hits	72	Target Neighborhood Hits	77	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UBP5	Gene names	HEY2, CHF1, GRL, HERP, HERP1, HRT2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Cardiovascular helix-loop-helix factor 1) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES- related repressor protein 2) (Protein gridlock homolog).

HEY2_MOUSE
NC score	0.584886 (rank : 15)	θ value	4.92598e-06 (rank : 14)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QUS4, Q3TZ99, Q8CD44	Gene names	Hey2, Chf1, Herp, Herp1, Hesr2, Hrt2
Domain Architecture	No domain graphic available
Description	Hairy/enhancer-of-split related with YRPW motif 2 (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HES-related repressor protein 2).

BHLH2_HUMAN
NC score	0.437821 (rank : 16)	θ value	0.000121331 (rank : 16)
Query Neighborhood Hits	72	Target Neighborhood Hits	80	Shared Neighborhood Hits	29
SwissProt Accessions	O14503, Q96TD3	Gene names	BHLHB2, DEC1, SHARP2, STRA13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Differentially expressed in chondrocytes protein 1) (DEC1) (Enhancer-of-split and hairy-related protein 2) (SHARP-2) (Stimulated with retinoic acid 13).

BHLH2_MOUSE
NC score	0.417193 (rank : 17)	θ value	0.00035302 (rank : 17)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	25
SwissProt Accessions	O35185, P97289	Gene names	Bhlhb2, Clast5, Stra13
Domain Architecture
Description	Class B basic helix-loop-helix protein 2 (bHLHB2) (Stimulated with retinoic acid 13) (E47 interaction protein 1) (eipl).

BHLH3_HUMAN
NC score	0.386499 (rank : 18)	θ value	0.21417 (rank : 18)
Query Neighborhood Hits	72	Target Neighborhood Hits	106	Shared Neighborhood Hits	29
SwissProt Accessions	Q9C0J9	Gene names	BHLHB3, DEC2, SHARP1
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (hDEC2) (Enhancer-of-split and hairy-related protein 1) (SHARP-1).

BHLH3_MOUSE
NC score	0.385187 (rank : 19)	θ value	0.21417 (rank : 19)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	28
SwissProt Accessions	Q99PV5	Gene names	Bhlhb3, Dec2
Domain Architecture
Description	Class B basic helix-loop-helix protein 3 (bHLHB3) (Differentially expressed in chondrocytes protein 2) (mDEC2).

BMAL1_MOUSE
NC score	0.114988 (rank : 20)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	72	Target Neighborhood Hits	121	Shared Neighborhood Hits	30
SwissProt Accessions	Q9WTL8, O88295, Q921S4, Q9R0U2, Q9WTL9	Gene names	Arntl, Bmal1
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Arnt3).

BMAL1_HUMAN
NC score	0.113528 (rank : 21)	θ value	2.36792 (rank : 37)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	30
SwissProt Accessions	O00327, O00313, O00314, O00315, O00316, O00317, Q99631, Q99649	Gene names	ARNTL, BMAL1, MOP3
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Brain and muscle ARNT-like 1) (Member of PAS protein 3) (Basic-helix-loop- helix-PAS orphan MOP3) (bHLH-PAS protein JAP3).

MITF_HUMAN
NC score	0.106530 (rank : 22)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	72	Target Neighborhood Hits	113	Shared Neighborhood Hits	27
SwissProt Accessions	O75030, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8	Gene names	MITF
Domain Architecture
Description	Microphthalmia-associated transcription factor.

MITF_MOUSE
NC score	0.103756 (rank : 23)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	27
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

NPAS2_MOUSE
NC score	0.092848 (rank : 24)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	72	Target Neighborhood Hits	132	Shared Neighborhood Hits	25
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

NCOA1_MOUSE
NC score	0.092669 (rank : 25)	θ value	0.62314 (rank : 29)
Query Neighborhood Hits	72	Target Neighborhood Hits	196	Shared Neighborhood Hits	25
SwissProt Accessions	P70365, P70366, Q61202, Q8CBI9	Gene names	Ncoa1, Src1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (Nuclear receptor coactivator protein 1) (mNRC-1).

NCOA1_HUMAN
NC score	0.092223 (rank : 26)	θ value	0.62314 (rank : 28)
Query Neighborhood Hits	72	Target Neighborhood Hits	198	Shared Neighborhood Hits	23
SwissProt Accessions	Q15788, O00150, O43792, O43793, Q13071, Q13420, Q6GVI5, Q7KYV3	Gene names	NCOA1, SRC1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 1 (EC 2.3.1.48) (NCoA-1) (Steroid receptor coactivator 1) (SRC-1) (RIP160) (Protein Hin-2) (NY-REN-52 antigen).

NPAS2_HUMAN
NC score	0.092084 (rank : 27)	θ value	0.365318 (rank : 21)
Query Neighborhood Hits	72	Target Neighborhood Hits	150	Shared Neighborhood Hits	24
SwissProt Accessions	Q99743, Q99629	Gene names	NPAS2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2) (Member of PAS protein 4) (MOP4).

TFE3_HUMAN
NC score	0.088653 (rank : 28)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	72	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	P19532, Q92757, Q92758, Q99964	Gene names	TFE3
Domain Architecture
Description	Transcription factor E3.

TFEB_MOUSE
NC score	0.083238 (rank : 29)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	72	Target Neighborhood Hits	119	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R210	Gene names	Tfeb, Tcfeb
Domain Architecture
Description	Transcription factor EB.

TFEB_HUMAN
NC score	0.083016 (rank : 30)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	72	Target Neighborhood Hits	111	Shared Neighborhood Hits	24
SwissProt Accessions	P19484, Q709B3, Q7Z6P9, Q9BRJ5, Q9UJD8	Gene names	TFEB
Domain Architecture
Description	Transcription factor EB.

CLOCK_HUMAN
NC score	0.079596 (rank : 31)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	72	Target Neighborhood Hits	127	Shared Neighborhood Hits	25
SwissProt Accessions	O15516, O14516, Q9UIT8	Gene names	CLOCK, KIAA0334
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (hCLOCK).

MLX_MOUSE
NC score	0.076462 (rank : 32)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	72	Target Neighborhood Hits	100	Shared Neighborhood Hits	19
SwissProt Accessions	O08609, Q9EQJ7, Q9EQJ8	Gene names	Mlx, Tcfl4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

MLX_HUMAN
NC score	0.075215 (rank : 33)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	72	Target Neighborhood Hits	95	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UH92, Q53XM6, Q96FL2, Q9H2V0, Q9H2V1, Q9H2V2, Q9NXN3	Gene names	MLX, TCFL4
Domain Architecture
Description	Max-like protein X (Max-like bHLHZip protein) (BigMax protein) (Protein Mlx) (Transcription factor-like protein 4).

CLOCK_MOUSE
NC score	0.073398 (rank : 34)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	72	Target Neighborhood Hits	148	Shared Neighborhood Hits	24
SwissProt Accessions	O08785	Gene names	Clock
Domain Architecture
Description	Circadian locomoter output cycles protein kaput (mCLOCK).

USF1_HUMAN
NC score	0.070422 (rank : 35)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	72	Target Neighborhood Hits	70	Shared Neighborhood Hits	20
SwissProt Accessions	P22415	Gene names	USF1, USF
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

USF1_MOUSE
NC score	0.070391 (rank : 36)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	72	Target Neighborhood Hits	71	Shared Neighborhood Hits	20
SwissProt Accessions	Q61069	Gene names	Usf1, Usf
Domain Architecture
Description	Upstream stimulatory factor 1 (Major late transcription factor 1).

SRBP1_HUMAN
NC score	0.068454 (rank : 37)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	72	Target Neighborhood Hits	225	Shared Neighborhood Hits	27
SwissProt Accessions	P36956, Q16062	Gene names	SREBF1, SREBP1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SRBP2_HUMAN
NC score	0.067252 (rank : 38)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	72	Target Neighborhood Hits	133	Shared Neighborhood Hits	20
SwissProt Accessions	Q12772, Q9UH04	Gene names	SREBF2, SREBP2
Domain Architecture
Description	Sterol regulatory element-binding protein 2 (SREBP-2) (Sterol regulatory element-binding transcription factor 2).

USF2_MOUSE
NC score	0.066963 (rank : 39)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	72	Target Neighborhood Hits	173	Shared Neighborhood Hits	21
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
NC score	0.062926 (rank : 40)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	72	Target Neighborhood Hits	155	Shared Neighborhood Hits	19
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

SRBP1_MOUSE
NC score	0.062802 (rank : 41)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	72	Target Neighborhood Hits	384	Shared Neighborhood Hits	28
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

ARNT2_MOUSE
NC score	0.060670 (rank : 42)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	72	Target Neighborhood Hits	115	Shared Neighborhood Hits	23
SwissProt Accessions	Q61324	Gene names	Arnt2
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

ARNT_HUMAN
NC score	0.060068 (rank : 43)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	P27540	Gene names	ARNT
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT_MOUSE
NC score	0.059454 (rank : 44)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	72	Target Neighborhood Hits	213	Shared Neighborhood Hits	24
SwissProt Accessions	P53762, Q60661	Gene names	Arnt
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator (ARNT protein) (Dioxin receptor, nuclear translocator) (Hypoxia-inducible factor 1 beta) (HIF-1 beta).

ARNT2_HUMAN
NC score	0.059284 (rank : 45)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	72	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HBZ2, O15024	Gene names	ARNT2, KIAA0307
Domain Architecture
Description	Aryl hydrocarbon receptor nuclear translocator 2 (ARNT protein 2).

SPR1B_MOUSE
NC score	0.055923 (rank : 46)	θ value	0.279714 (rank : 20)
Query Neighborhood Hits	72	Target Neighborhood Hits	395	Shared Neighborhood Hits	10
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

ZN385_HUMAN
NC score	0.052755 (rank : 47)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	72	Target Neighborhood Hits	614	Shared Neighborhood Hits	14
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

AHR_HUMAN
NC score	0.052024 (rank : 48)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	72	Target Neighborhood Hits	47	Shared Neighborhood Hits	15
SwissProt Accessions	P35869, Q13728, Q13803, Q13804	Gene names	AHR
Domain Architecture
Description	Aryl hydrocarbon receptor precursor (Ah receptor) (AhR).

NCOA3_HUMAN
NC score	0.049249 (rank : 49)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	72	Target Neighborhood Hits	171	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y6Q9, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7	Gene names	NCOA3, AIB1, RAC3, TRAM1
Domain Architecture
Description	Nuclear receptor coactivator 3 (EC 2.3.1.48) (NCoA-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) (ACTR) (Receptor-associated coactivator 3) (RAC-3) (Amplified in breast cancer-1 protein) (AIB-1) (Steroid receptor coactivator protein 3) (SRC-3) (CBP-interacting protein) (pCIP).

ZAR1_HUMAN
NC score	0.040381 (rank : 50)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	72	Target Neighborhood Hits	163	Shared Neighborhood Hits	4
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

SON_HUMAN
NC score	0.035338 (rank : 51)	θ value	0.813845 (rank : 30)
Query Neighborhood Hits	72	Target Neighborhood Hits	1568	Shared Neighborhood Hits	35
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

TREF1_MOUSE
NC score	0.034346 (rank : 52)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	72	Target Neighborhood Hits	682	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BXJ2, Q6PCQ4, Q80X25, Q810H8, Q8BY31	Gene names	Trerf1
Domain Architecture	No domain graphic available
Description	Transcriptional-regulating factor 1 (Transcriptional-regulating protein 132) (Zinc finger transcription factor TReP-132).

MEF2B_MOUSE
NC score	0.032671 (rank : 53)	θ value	1.06291 (rank : 31)
Query Neighborhood Hits	72	Target Neighborhood Hits	218	Shared Neighborhood Hits	6
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

CEL_HUMAN
NC score	0.032594 (rank : 54)	θ value	0.62314 (rank : 26)
Query Neighborhood Hits	72	Target Neighborhood Hits	896	Shared Neighborhood Hits	22
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

PCLO_MOUSE
NC score	0.032349 (rank : 55)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	72	Target Neighborhood Hits	2275	Shared Neighborhood Hits	30
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

K1543_MOUSE
NC score	0.031126 (rank : 56)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	72	Target Neighborhood Hits	497	Shared Neighborhood Hits	14
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

LIMD1_HUMAN
NC score	0.028779 (rank : 57)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	72	Target Neighborhood Hits	201	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UGP4, Q9BQQ9, Q9NQ47	Gene names	LIMD1
Domain Architecture
Description	LIM domain-containing protein 1.

TM108_MOUSE
NC score	0.028706 (rank : 58)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	72	Target Neighborhood Hits	336	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

MUCDL_HUMAN
NC score	0.026887 (rank : 59)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	72	Target Neighborhood Hits	777	Shared Neighborhood Hits	16
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SCAP_HUMAN
NC score	0.026074 (rank : 60)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	72	Target Neighborhood Hits	368	Shared Neighborhood Hits	4
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

TNR1A_HUMAN
NC score	0.025369 (rank : 61)	θ value	1.81305 (rank : 36)
Query Neighborhood Hits	72	Target Neighborhood Hits	121	Shared Neighborhood Hits	3
SwissProt Accessions	P19438	Gene names	TNFRSF1A, TNFAR, TNFR1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 1A precursor (p60) (TNF-R1) (TNF-RI) (TNFR-I) (p55) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)].

SCO1_HUMAN
NC score	0.023118 (rank : 62)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	72	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	O75880	Gene names	SCO1, SCOD1
Domain Architecture
Description	SCO1 protein homolog, mitochondrial precursor.

ZFPL1_HUMAN
NC score	0.020614 (rank : 63)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	72	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	O95159, O14616, Q9UID0	Gene names	ZFPL1
Domain Architecture	No domain graphic available
Description	Zinc finger protein-like 1 (Zinc finger protein MCG4).

LCP2_HUMAN
NC score	0.020534 (rank : 64)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	72	Target Neighborhood Hits	531	Shared Neighborhood Hits	14
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MINT_MOUSE
NC score	0.019949 (rank : 65)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	72	Target Neighborhood Hits	1514	Shared Neighborhood Hits	21
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

FXL19_HUMAN
NC score	0.018478 (rank : 66)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	72	Target Neighborhood Hits	147	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

RGS3_MOUSE
NC score	0.018285 (rank : 67)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	72	Target Neighborhood Hits	1621	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TAU_MOUSE
NC score	0.018160 (rank : 68)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	72	Target Neighborhood Hits	502	Shared Neighborhood Hits	12
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

UB7I1_MOUSE
NC score	0.017971 (rank : 69)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	72	Target Neighborhood Hits	206	Shared Neighborhood Hits	9
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

FXL19_MOUSE
NC score	0.016489 (rank : 70)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	72	Target Neighborhood Hits	217	Shared Neighborhood Hits	6
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

MLL3_HUMAN
NC score	0.016059 (rank : 71)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	72	Target Neighborhood Hits	1644	Shared Neighborhood Hits	25
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

ELL_HUMAN
NC score	0.016048 (rank : 72)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	72	Target Neighborhood Hits	183	Shared Neighborhood Hits	5
SwissProt Accessions	P55199	Gene names	ELL, C19orf17
Domain Architecture
Description	RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein).

ERCC2_MOUSE
NC score	0.015841 (rank : 73)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	72	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O08811, Q9DC01	Gene names	Ercc2, Xpd
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

SAPS1_HUMAN
NC score	0.015111 (rank : 74)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	72	Target Neighborhood Hits	704	Shared Neighborhood Hits	17
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SYNP2_HUMAN
NC score	0.013851 (rank : 75)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	72	Target Neighborhood Hits	323	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UMS6, Q9UK89	Gene names	SYNPO2
Domain Architecture	No domain graphic available
Description	Synaptopodin-2 (Myopodin) (Genethonin 2).

K1802_HUMAN
NC score	0.013498 (rank : 76)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	72	Target Neighborhood Hits	1378	Shared Neighborhood Hits	22
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

TCGAP_MOUSE
NC score	0.013470 (rank : 77)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	72	Target Neighborhood Hits	409	Shared Neighborhood Hits	13
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RTN1_MOUSE
NC score	0.012555 (rank : 78)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	72	Target Neighborhood Hits	189	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K0T0, Q8K4S4	Gene names	Rtn1, Nsp
Domain Architecture	No domain graphic available
Description	Reticulon-1 (Neuroendocrine-specific protein).

CAC1G_HUMAN
NC score	0.010776 (rank : 79)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	72	Target Neighborhood Hits	587	Shared Neighborhood Hits	12
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

DDR1_HUMAN
NC score	0.006269 (rank : 80)	θ value	1.81305 (rank : 35)
Query Neighborhood Hits	72	Target Neighborhood Hits	819	Shared Neighborhood Hits	6
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
NC score	0.006007 (rank : 81)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	72	Target Neighborhood Hits	818	Shared Neighborhood Hits	6
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

AMOL2_MOUSE
NC score	0.004728 (rank : 82)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	72	Target Neighborhood Hits	591	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K371, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q9QUS0	Gene names	Amotl2
Domain Architecture	No domain graphic available
Description	Angiomotin-like protein 2.

ABCA7_HUMAN
NC score	0.004700 (rank : 83)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	72	Target Neighborhood Hits	144	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

HXA2_HUMAN
NC score	0.003973 (rank : 84)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	72	Target Neighborhood Hits	370	Shared Neighborhood Hits	2
SwissProt Accessions	O43364	Gene names	HOXA2
Domain Architecture	No domain graphic available
Description	Homeobox protein Hox-A2.

E2AK4_MOUSE
NC score	0.001794 (rank : 85)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	72	Target Neighborhood Hits	984	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QZ05, Q6GQT4, Q6ZPT5, Q8C5S0, Q8CIF5, Q9CT30, Q9CUV9, Q9ESB6, Q9ESB7, Q9ESB8	Gene names	Eif2ak4, Gcn2, Kiaa1338
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) (GCN2-like protein) (mGCN2).

LATS2_HUMAN
NC score	0.001695 (rank : 86)	θ value	4.03905 (rank : 42)
Query Neighborhood Hits	72	Target Neighborhood Hits	884	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NRM7, Q9P2X1	Gene names	LATS2, KPM
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Kinase phosphorylated during mitosis protein) (Warts-like kinase).

EGR4_HUMAN
NC score	-0.000063 (rank : 87)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	72	Target Neighborhood Hits	939	Shared Neighborhood Hits	8
SwissProt Accessions	Q05215	Gene names	EGR4
Domain Architecture
Description	Early growth response protein 4 (EGR-4) (AT133).