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Network neighborhood for query Sequence : LCP2_HUMAN

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LCP2_HUMAN
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

LCP2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	531	Target Neighborhood Hits	531	Shared Neighborhood Hits	531
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	0 (rank : 2)	NC score	0.806570 (rank : 2)
Query Neighborhood Hits	531	Target Neighborhood Hits	177	Shared Neighborhood Hits	127
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BLNK_MOUSE
θ value	2.77775e-25 (rank : 3)	NC score	0.586558 (rank : 3)
Query Neighborhood Hits	531	Target Neighborhood Hits	296	Shared Neighborhood Hits	142
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BLNK_HUMAN
θ value	8.08199e-25 (rank : 4)	NC score	0.551823 (rank : 4)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	96
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

PLCG1_HUMAN
θ value	1.17247e-07 (rank : 5)	NC score	0.284236 (rank : 12)
Query Neighborhood Hits	531	Target Neighborhood Hits	293	Shared Neighborhood Hits	84
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	1.17247e-07 (rank : 6)	NC score	0.282660 (rank : 13)
Query Neighborhood Hits	531	Target Neighborhood Hits	314	Shared Neighborhood Hits	88
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SRRM1_HUMAN
θ value	2.21117e-06 (rank : 7)	NC score	0.230767 (rank : 39)
Query Neighborhood Hits	531	Target Neighborhood Hits	690	Shared Neighborhood Hits	135
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

WASIP_HUMAN
θ value	2.21117e-06 (rank : 8)	NC score	0.287889 (rank : 11)
Query Neighborhood Hits	531	Target Neighborhood Hits	458	Shared Neighborhood Hits	121
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

NCK1_HUMAN
θ value	3.77169e-06 (rank : 9)	NC score	0.289507 (rank : 9)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	86
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

DAPP1_HUMAN
θ value	1.09739e-05 (rank : 10)	NC score	0.315183 (rank : 6)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PRG4_HUMAN
θ value	2.44474e-05 (rank : 11)	NC score	0.173639 (rank : 104)
Query Neighborhood Hits	531	Target Neighborhood Hits	764	Shared Neighborhood Hits	137
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SHC3_MOUSE
θ value	2.44474e-05 (rank : 12)	NC score	0.274349 (rank : 15)
Query Neighborhood Hits	531	Target Neighborhood Hits	151	Shared Neighborhood Hits	77
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

DAPP1_MOUSE
θ value	3.19293e-05 (rank : 13)	NC score	0.307550 (rank : 8)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NCOA6_HUMAN
θ value	3.19293e-05 (rank : 14)	NC score	0.326547 (rank : 5)
Query Neighborhood Hits	531	Target Neighborhood Hits	1202	Shared Neighborhood Hits	298
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ARI1B_HUMAN
θ value	4.1701e-05 (rank : 15)	NC score	0.214210 (rank : 51)
Query Neighborhood Hits	531	Target Neighborhood Hits	567	Shared Neighborhood Hits	159
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

NCK2_HUMAN
θ value	5.44631e-05 (rank : 16)	NC score	0.288537 (rank : 10)
Query Neighborhood Hits	531	Target Neighborhood Hits	310	Shared Neighborhood Hits	94
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

SRC_HUMAN
θ value	7.1131e-05 (rank : 17)	NC score	0.123154 (rank : 231)
Query Neighborhood Hits	531	Target Neighborhood Hits	1058	Shared Neighborhood Hits	103
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	7.1131e-05 (rank : 18)	NC score	0.123300 (rank : 230)
Query Neighborhood Hits	531	Target Neighborhood Hits	1033	Shared Neighborhood Hits	103
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

WASIP_MOUSE
θ value	9.29e-05 (rank : 19)	NC score	0.261691 (rank : 20)
Query Neighborhood Hits	531	Target Neighborhood Hits	392	Shared Neighborhood Hits	113
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

CSKI1_HUMAN
θ value	0.000121331 (rank : 20)	NC score	0.110396 (rank : 285)
Query Neighborhood Hits	531	Target Neighborhood Hits	997	Shared Neighborhood Hits	183
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MBD6_HUMAN
θ value	0.000121331 (rank : 21)	NC score	0.200504 (rank : 63)
Query Neighborhood Hits	531	Target Neighborhood Hits	349	Shared Neighborhood Hits	96
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

BTK_HUMAN
θ value	0.000158464 (rank : 22)	NC score	0.123434 (rank : 229)
Query Neighborhood Hits	531	Target Neighborhood Hits	1026	Shared Neighborhood Hits	96
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SHC3_HUMAN
θ value	0.000158464 (rank : 23)	NC score	0.264028 (rank : 19)
Query Neighborhood Hits	531	Target Neighborhood Hits	155	Shared Neighborhood Hits	76
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

MLL3_MOUSE
θ value	0.00020696 (rank : 24)	NC score	0.241366 (rank : 32)
Query Neighborhood Hits	531	Target Neighborhood Hits	1399	Shared Neighborhood Hits	253
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

PLCG2_HUMAN
θ value	0.00020696 (rank : 25)	NC score	0.267665 (rank : 17)
Query Neighborhood Hits	531	Target Neighborhood Hits	280	Shared Neighborhood Hits	83
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PRP1_HUMAN
θ value	0.00020696 (rank : 26)	NC score	0.198249 (rank : 66)
Query Neighborhood Hits	531	Target Neighborhood Hits	385	Shared Neighborhood Hits	102
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

SPEG_MOUSE
θ value	0.00020696 (rank : 27)	NC score	0.083660 (rank : 437)
Query Neighborhood Hits	531	Target Neighborhood Hits	1959	Shared Neighborhood Hits	246
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SFPQ_HUMAN
θ value	0.000270298 (rank : 28)	NC score	0.137104 (rank : 191)
Query Neighborhood Hits	531	Target Neighborhood Hits	986	Shared Neighborhood Hits	125
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

BTK_MOUSE
θ value	0.00035302 (rank : 29)	NC score	0.122762 (rank : 232)
Query Neighborhood Hits	531	Target Neighborhood Hits	1017	Shared Neighborhood Hits	96
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CEL_HUMAN
θ value	0.00035302 (rank : 30)	NC score	0.223597 (rank : 45)
Query Neighborhood Hits	531	Target Neighborhood Hits	896	Shared Neighborhood Hits	229
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

SRRM1_MOUSE
θ value	0.00035302 (rank : 31)	NC score	0.268043 (rank : 16)
Query Neighborhood Hits	531	Target Neighborhood Hits	966	Shared Neighborhood Hits	216
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

PRB4S_HUMAN
θ value	0.000461057 (rank : 32)	NC score	0.199117 (rank : 65)
Query Neighborhood Hits	531	Target Neighborhood Hits	330	Shared Neighborhood Hits	90
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

MUC2_HUMAN
θ value	0.000786445 (rank : 33)	NC score	0.102420 (rank : 324)
Query Neighborhood Hits	531	Target Neighborhood Hits	906	Shared Neighborhood Hits	121
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

NCOA6_MOUSE
θ value	0.000786445 (rank : 34)	NC score	0.278267 (rank : 14)
Query Neighborhood Hits	531	Target Neighborhood Hits	1076	Shared Neighborhood Hits	261
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

PCLO_HUMAN
θ value	0.000786445 (rank : 35)	NC score	0.213328 (rank : 52)
Query Neighborhood Hits	531	Target Neighborhood Hits	2046	Shared Neighborhood Hits	315
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RERE_MOUSE
θ value	0.000786445 (rank : 36)	NC score	0.181486 (rank : 86)
Query Neighborhood Hits	531	Target Neighborhood Hits	785	Shared Neighborhood Hits	173
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

RGS3_MOUSE
θ value	0.000786445 (rank : 37)	NC score	0.261608 (rank : 21)
Query Neighborhood Hits	531	Target Neighborhood Hits	1621	Shared Neighborhood Hits	333
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

RAPH1_HUMAN
θ value	0.00102713 (rank : 38)	NC score	0.192219 (rank : 75)
Query Neighborhood Hits	531	Target Neighborhood Hits	593	Shared Neighborhood Hits	159
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

ENAH_MOUSE
θ value	0.00134147 (rank : 39)	NC score	0.137689 (rank : 185)
Query Neighborhood Hits	531	Target Neighborhood Hits	919	Shared Neighborhood Hits	140
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

GRAP_MOUSE
θ value	0.00134147 (rank : 40)	NC score	0.254105 (rank : 24)
Query Neighborhood Hits	531	Target Neighborhood Hits	309	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

EP300_HUMAN
θ value	0.00175202 (rank : 41)	NC score	0.165990 (rank : 119)
Query Neighborhood Hits	531	Target Neighborhood Hits	821	Shared Neighborhood Hits	181
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

GRAP_HUMAN
θ value	0.00175202 (rank : 42)	NC score	0.253789 (rank : 25)
Query Neighborhood Hits	531	Target Neighborhood Hits	307	Shared Neighborhood Hits	89
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

PRG4_MOUSE
θ value	0.00175202 (rank : 43)	NC score	0.154587 (rank : 139)
Query Neighborhood Hits	531	Target Neighborhood Hits	624	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SFPQ_MOUSE
θ value	0.00175202 (rank : 44)	NC score	0.140796 (rank : 178)
Query Neighborhood Hits	531	Target Neighborhood Hits	958	Shared Neighborhood Hits	119
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

SHAN1_HUMAN
θ value	0.00175202 (rank : 45)	NC score	0.102614 (rank : 321)
Query Neighborhood Hits	531	Target Neighborhood Hits	1041	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ZIM10_MOUSE
θ value	0.00175202 (rank : 46)	NC score	0.144680 (rank : 167)
Query Neighborhood Hits	531	Target Neighborhood Hits	430	Shared Neighborhood Hits	125
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

FYB_HUMAN
θ value	0.00228821 (rank : 47)	NC score	0.221720 (rank : 47)
Query Neighborhood Hits	531	Target Neighborhood Hits	379	Shared Neighborhood Hits	113
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

MISS_MOUSE
θ value	0.00228821 (rank : 48)	NC score	0.248450 (rank : 28)
Query Neighborhood Hits	531	Target Neighborhood Hits	444	Shared Neighborhood Hits	149
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

PTN11_HUMAN
θ value	0.00228821 (rank : 49)	NC score	0.168094 (rank : 115)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	0.00228821 (rank : 50)	NC score	0.168115 (rank : 114)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

RBM12_MOUSE
θ value	0.00228821 (rank : 51)	NC score	0.118293 (rank : 249)
Query Neighborhood Hits	531	Target Neighborhood Hits	313	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

WASF1_MOUSE
θ value	0.00228821 (rank : 52)	NC score	0.171942 (rank : 109)
Query Neighborhood Hits	531	Target Neighborhood Hits	261	Shared Neighborhood Hits	78
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

HRX_HUMAN
θ value	0.00298849 (rank : 53)	NC score	0.144510 (rank : 168)
Query Neighborhood Hits	531	Target Neighborhood Hits	825	Shared Neighborhood Hits	133
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

MLL2_HUMAN
θ value	0.00298849 (rank : 54)	NC score	0.175639 (rank : 98)
Query Neighborhood Hits	531	Target Neighborhood Hits	1788	Shared Neighborhood Hits	255
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

WASF1_HUMAN
θ value	0.00298849 (rank : 55)	NC score	0.172634 (rank : 106)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	80
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WASP_HUMAN
θ value	0.00298849 (rank : 56)	NC score	0.175736 (rank : 97)
Query Neighborhood Hits	531	Target Neighborhood Hits	195	Shared Neighborhood Hits	74
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

TITIN_HUMAN
θ value	0.00390308 (rank : 57)	NC score	0.060751 (rank : 637)
Query Neighborhood Hits	531	Target Neighborhood Hits	2923	Shared Neighborhood Hits	215
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

WASL_MOUSE
θ value	0.00390308 (rank : 58)	NC score	0.210944 (rank : 53)
Query Neighborhood Hits	531	Target Neighborhood Hits	339	Shared Neighborhood Hits	100
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

FGR_MOUSE
θ value	0.00509761 (rank : 59)	NC score	0.127867 (rank : 216)
Query Neighborhood Hits	531	Target Neighborhood Hits	1069	Shared Neighborhood Hits	104
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

K1802_HUMAN
θ value	0.00509761 (rank : 60)	NC score	0.146181 (rank : 160)
Query Neighborhood Hits	531	Target Neighborhood Hits	1378	Shared Neighborhood Hits	222
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

FMNL_HUMAN
θ value	0.00665767 (rank : 61)	NC score	0.134606 (rank : 197)
Query Neighborhood Hits	531	Target Neighborhood Hits	529	Shared Neighborhood Hits	102
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

RERE_HUMAN
θ value	0.00665767 (rank : 62)	NC score	0.173902 (rank : 102)
Query Neighborhood Hits	531	Target Neighborhood Hits	779	Shared Neighborhood Hits	166
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SHC2_MOUSE
θ value	0.00665767 (rank : 63)	NC score	0.246416 (rank : 29)
Query Neighborhood Hits	531	Target Neighborhood Hits	144	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

WASF2_MOUSE
θ value	0.00665767 (rank : 64)	NC score	0.181050 (rank : 88)
Query Neighborhood Hits	531	Target Neighborhood Hits	315	Shared Neighborhood Hits	104
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

ATN1_HUMAN
θ value	0.00869519 (rank : 65)	NC score	0.194008 (rank : 72)
Query Neighborhood Hits	531	Target Neighborhood Hits	676	Shared Neighborhood Hits	131
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

FGR_HUMAN
θ value	0.00869519 (rank : 66)	NC score	0.124138 (rank : 226)
Query Neighborhood Hits	531	Target Neighborhood Hits	1067	Shared Neighborhood Hits	104
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYB_MOUSE
θ value	0.00869519 (rank : 67)	NC score	0.122356 (rank : 235)
Query Neighborhood Hits	531	Target Neighborhood Hits	194	Shared Neighborhood Hits	42
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

PRRT3_HUMAN
θ value	0.00869519 (rank : 68)	NC score	0.311008 (rank : 7)
Query Neighborhood Hits	531	Target Neighborhood Hits	998	Shared Neighborhood Hits	262
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

RNC_HUMAN
θ value	0.00869519 (rank : 69)	NC score	0.121814 (rank : 238)
Query Neighborhood Hits	531	Target Neighborhood Hits	176	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

SRRM2_HUMAN
θ value	0.00869519 (rank : 70)	NC score	0.172088 (rank : 108)
Query Neighborhood Hits	531	Target Neighborhood Hits	1296	Shared Neighborhood Hits	196
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

TENS1_HUMAN
θ value	0.00869519 (rank : 71)	NC score	0.119834 (rank : 243)
Query Neighborhood Hits	531	Target Neighborhood Hits	400	Shared Neighborhood Hits	118
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

ZIM10_HUMAN
θ value	0.00869519 (rank : 72)	NC score	0.177454 (rank : 96)
Query Neighborhood Hits	531	Target Neighborhood Hits	577	Shared Neighborhood Hits	181
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

AB1IP_MOUSE
θ value	0.0113563 (rank : 73)	NC score	0.126057 (rank : 222)
Query Neighborhood Hits	531	Target Neighborhood Hits	181	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

CCNK_MOUSE
θ value	0.0113563 (rank : 74)	NC score	0.136027 (rank : 193)
Query Neighborhood Hits	531	Target Neighborhood Hits	350	Shared Neighborhood Hits	100
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

GGN_HUMAN
θ value	0.0113563 (rank : 75)	NC score	0.153290 (rank : 142)
Query Neighborhood Hits	531	Target Neighborhood Hits	269	Shared Neighborhood Hits	80
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

MKL1_MOUSE
θ value	0.0113563 (rank : 76)	NC score	0.159372 (rank : 132)
Query Neighborhood Hits	531	Target Neighborhood Hits	667	Shared Neighborhood Hits	174
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

WBS14_HUMAN
θ value	0.0113563 (rank : 77)	NC score	0.113953 (rank : 263)
Query Neighborhood Hits	531	Target Neighborhood Hits	273	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

BMX_HUMAN
θ value	0.0148317 (rank : 78)	NC score	0.111137 (rank : 280)
Query Neighborhood Hits	531	Target Neighborhood Hits	942	Shared Neighborhood Hits	89
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

BRD4_MOUSE
θ value	0.0148317 (rank : 79)	NC score	0.117200 (rank : 253)
Query Neighborhood Hits	531	Target Neighborhood Hits	845	Shared Neighborhood Hits	129
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

FMN1A_MOUSE
θ value	0.0148317 (rank : 80)	NC score	0.140571 (rank : 179)
Query Neighborhood Hits	531	Target Neighborhood Hits	423	Shared Neighborhood Hits	101
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

FMN1B_MOUSE
θ value	0.0148317 (rank : 81)	NC score	0.132431 (rank : 203)
Query Neighborhood Hits	531	Target Neighborhood Hits	447	Shared Neighborhood Hits	103
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

MLL4_HUMAN
θ value	0.0148317 (rank : 82)	NC score	0.177484 (rank : 95)
Query Neighborhood Hits	531	Target Neighborhood Hits	722	Shared Neighborhood Hits	159
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

PCQAP_HUMAN
θ value	0.0148317 (rank : 83)	NC score	0.128830 (rank : 211)
Query Neighborhood Hits	531	Target Neighborhood Hits	549	Shared Neighborhood Hits	78
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

PTN23_MOUSE
θ value	0.0148317 (rank : 84)	NC score	0.098140 (rank : 353)
Query Neighborhood Hits	531	Target Neighborhood Hits	726	Shared Neighborhood Hits	131
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

SMAD5_MOUSE
θ value	0.0148317 (rank : 85)	NC score	0.054148 (rank : 808)
Query Neighborhood Hits	531	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

TCOF_MOUSE
θ value	0.0148317 (rank : 86)	NC score	0.107342 (rank : 300)
Query Neighborhood Hits	531	Target Neighborhood Hits	471	Shared Neighborhood Hits	75
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

WASL_HUMAN
θ value	0.0148317 (rank : 87)	NC score	0.194896 (rank : 71)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	102
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

3BP2_HUMAN
θ value	0.0193708 (rank : 88)	NC score	0.145629 (rank : 162)
Query Neighborhood Hits	531	Target Neighborhood Hits	296	Shared Neighborhood Hits	108
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

BMX_MOUSE
θ value	0.0193708 (rank : 89)	NC score	0.110938 (rank : 283)
Query Neighborhood Hits	531	Target Neighborhood Hits	912	Shared Neighborhood Hits	88
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

GCX1_HUMAN
θ value	0.0193708 (rank : 90)	NC score	0.074693 (rank : 506)
Query Neighborhood Hits	531	Target Neighborhood Hits	132	Shared Neighborhood Hits	24
SwissProt Accessions	Q96NM4, Q5TE33, Q5TE34, Q5TE35, Q96IC9, Q9BQN5	Gene names	GCX1, C20orf100
Domain Architecture
Description	Granulosa cell HMG box protein 1 (GCX-1).

K1802_MOUSE
θ value	0.0193708 (rank : 91)	NC score	0.227522 (rank : 44)
Query Neighborhood Hits	531	Target Neighborhood Hits	1596	Shared Neighborhood Hits	276
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

RBM12_HUMAN
θ value	0.0193708 (rank : 92)	NC score	0.107877 (rank : 296)
Query Neighborhood Hits	531	Target Neighborhood Hits	298	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NTZ6, O94865, Q8N3B1, Q9H196	Gene names	RBM12, KIAA0765
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

WIRE_HUMAN
θ value	0.0193708 (rank : 93)	NC score	0.205508 (rank : 58)
Query Neighborhood Hits	531	Target Neighborhood Hits	329	Shared Neighborhood Hits	102
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

WIRE_MOUSE
θ value	0.0193708 (rank : 94)	NC score	0.201935 (rank : 59)
Query Neighborhood Hits	531	Target Neighborhood Hits	310	Shared Neighborhood Hits	100
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

3BP1_HUMAN
θ value	0.0252991 (rank : 95)	NC score	0.073557 (rank : 516)
Query Neighborhood Hits	531	Target Neighborhood Hits	376	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ANK2_HUMAN
θ value	0.0252991 (rank : 96)	NC score	0.117775 (rank : 251)
Query Neighborhood Hits	531	Target Neighborhood Hits	1615	Shared Neighborhood Hits	238
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CIC_MOUSE
θ value	0.0252991 (rank : 97)	NC score	0.108586 (rank : 292)
Query Neighborhood Hits	531	Target Neighborhood Hits	742	Shared Neighborhood Hits	153
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CN032_HUMAN
θ value	0.0252991 (rank : 98)	NC score	0.169638 (rank : 111)
Query Neighborhood Hits	531	Target Neighborhood Hits	267	Shared Neighborhood Hits	74
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

CSKI2_HUMAN
θ value	0.0252991 (rank : 99)	NC score	0.073523 (rank : 517)
Query Neighborhood Hits	531	Target Neighborhood Hits	747	Shared Neighborhood Hits	96
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

HNRL1_MOUSE
θ value	0.0252991 (rank : 100)	NC score	0.089698 (rank : 402)
Query Neighborhood Hits	531	Target Neighborhood Hits	200	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

LAD1_HUMAN
θ value	0.0252991 (rank : 101)	NC score	0.162841 (rank : 124)
Query Neighborhood Hits	531	Target Neighborhood Hits	441	Shared Neighborhood Hits	111
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

PTN6_MOUSE
θ value	0.0252991 (rank : 102)	NC score	0.137449 (rank : 186)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	0.0252991 (rank : 103)	NC score	0.230973 (rank : 38)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	79
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SHC1_MOUSE
θ value	0.0252991 (rank : 104)	NC score	0.237249 (rank : 36)
Query Neighborhood Hits	531	Target Neighborhood Hits	180	Shared Neighborhood Hits	85
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	0.0252991 (rank : 105)	NC score	0.239911 (rank : 34)
Query Neighborhood Hits	531	Target Neighborhood Hits	170	Shared Neighborhood Hits	82
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

HCK_HUMAN
θ value	0.0330416 (rank : 106)	NC score	0.111638 (rank : 275)
Query Neighborhood Hits	531	Target Neighborhood Hits	1035	Shared Neighborhood Hits	98
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	0.0330416 (rank : 107)	NC score	0.111973 (rank : 271)
Query Neighborhood Hits	531	Target Neighborhood Hits	1029	Shared Neighborhood Hits	99
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

IWS1_HUMAN
θ value	0.0330416 (rank : 108)	NC score	0.144495 (rank : 169)
Query Neighborhood Hits	531	Target Neighborhood Hits	1241	Shared Neighborhood Hits	163
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

PTK6_MOUSE
θ value	0.0330416 (rank : 109)	NC score	0.102099 (rank : 325)
Query Neighborhood Hits	531	Target Neighborhood Hits	1026	Shared Neighborhood Hits	91
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TJAP1_HUMAN
θ value	0.0330416 (rank : 110)	NC score	0.055540 (rank : 776)
Query Neighborhood Hits	531	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7	Gene names	TJAP1, PILT, TJP4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

AFF1_MOUSE
θ value	0.0431538 (rank : 111)	NC score	0.109372 (rank : 287)
Query Neighborhood Hits	531	Target Neighborhood Hits	351	Shared Neighborhood Hits	78
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

CSKI1_MOUSE
θ value	0.0431538 (rank : 112)	NC score	0.117879 (rank : 250)
Query Neighborhood Hits	531	Target Neighborhood Hits	1031	Shared Neighborhood Hits	219
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

G3BP2_HUMAN
θ value	0.0431538 (rank : 113)	NC score	0.071844 (rank : 533)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

LYN_HUMAN
θ value	0.0431538 (rank : 114)	NC score	0.108410 (rank : 293)
Query Neighborhood Hits	531	Target Neighborhood Hits	1022	Shared Neighborhood Hits	94
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

SOS2_HUMAN
θ value	0.0431538 (rank : 115)	NC score	0.053132 (rank : 822)
Query Neighborhood Hits	531	Target Neighborhood Hits	193	Shared Neighborhood Hits	37
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

TXK_HUMAN
θ value	0.0431538 (rank : 116)	NC score	0.113763 (rank : 266)
Query Neighborhood Hits	531	Target Neighborhood Hits	971	Shared Neighborhood Hits	91
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

WASF4_HUMAN
θ value	0.0431538 (rank : 117)	NC score	0.177694 (rank : 94)
Query Neighborhood Hits	531	Target Neighborhood Hits	282	Shared Neighborhood Hits	100
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

BCL9_MOUSE
θ value	0.0563607 (rank : 118)	NC score	0.221524 (rank : 48)
Query Neighborhood Hits	531	Target Neighborhood Hits	770	Shared Neighborhood Hits	208
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

CPSF6_HUMAN
θ value	0.0563607 (rank : 119)	NC score	0.146882 (rank : 157)
Query Neighborhood Hits	531	Target Neighborhood Hits	359	Shared Neighborhood Hits	93
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

CPSF6_MOUSE
θ value	0.0563607 (rank : 120)	NC score	0.148298 (rank : 152)
Query Neighborhood Hits	531	Target Neighborhood Hits	356	Shared Neighborhood Hits	93
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

LYN_MOUSE
θ value	0.0563607 (rank : 121)	NC score	0.108608 (rank : 291)
Query Neighborhood Hits	531	Target Neighborhood Hits	1023	Shared Neighborhood Hits	94
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MAGE1_HUMAN
θ value	0.0563607 (rank : 122)	NC score	0.217695 (rank : 50)
Query Neighborhood Hits	531	Target Neighborhood Hits	1389	Shared Neighborhood Hits	283
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

PRR12_HUMAN
θ value	0.0563607 (rank : 123)	NC score	0.181296 (rank : 87)
Query Neighborhood Hits	531	Target Neighborhood Hits	460	Shared Neighborhood Hits	117
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

SRRM2_MOUSE
θ value	0.0563607 (rank : 124)	NC score	0.191426 (rank : 76)
Query Neighborhood Hits	531	Target Neighborhood Hits	1470	Shared Neighborhood Hits	221
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

WBP11_HUMAN
θ value	0.0563607 (rank : 125)	NC score	0.173219 (rank : 105)
Query Neighborhood Hits	531	Target Neighborhood Hits	354	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	0.0563607 (rank : 126)	NC score	0.172542 (rank : 107)
Query Neighborhood Hits	531	Target Neighborhood Hits	362	Shared Neighborhood Hits	91
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

ARI5B_HUMAN
θ value	0.0736092 (rank : 127)	NC score	0.075425 (rank : 497)
Query Neighborhood Hits	531	Target Neighborhood Hits	328	Shared Neighborhood Hits	53
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

CJ078_MOUSE
θ value	0.0736092 (rank : 128)	NC score	0.153629 (rank : 140)
Query Neighborhood Hits	531	Target Neighborhood Hits	559	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

FGD1_HUMAN
θ value	0.0736092 (rank : 129)	NC score	0.052492 (rank : 839)
Query Neighborhood Hits	531	Target Neighborhood Hits	367	Shared Neighborhood Hits	78
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MILK1_MOUSE
θ value	0.0736092 (rank : 130)	NC score	0.138368 (rank : 182)
Query Neighborhood Hits	531	Target Neighborhood Hits	788	Shared Neighborhood Hits	188
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

PRDM2_HUMAN
θ value	0.0736092 (rank : 131)	NC score	0.036746 (rank : 947)
Query Neighborhood Hits	531	Target Neighborhood Hits	1135	Shared Neighborhood Hits	108
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

PS1C2_HUMAN
θ value	0.0736092 (rank : 132)	NC score	0.139130 (rank : 180)
Query Neighborhood Hits	531	Target Neighborhood Hits	66	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

SF3A2_HUMAN
θ value	0.0736092 (rank : 133)	NC score	0.144133 (rank : 170)
Query Neighborhood Hits	531	Target Neighborhood Hits	263	Shared Neighborhood Hits	80
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

SH21B_HUMAN
θ value	0.0736092 (rank : 134)	NC score	0.229200 (rank : 42)
Query Neighborhood Hits	531	Target Neighborhood Hits	101	Shared Neighborhood Hits	58
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SMAD5_HUMAN
θ value	0.0736092 (rank : 135)	NC score	0.048796 (rank : 896)
Query Neighborhood Hits	531	Target Neighborhood Hits	57	Shared Neighborhood Hits	14
SwissProt Accessions	Q99717, O14688, Q15798, Q9UQA1	Gene names	SMAD5, MADH5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (hSmad5) (JV5-1).

TAB3_HUMAN
θ value	0.0736092 (rank : 136)	NC score	0.090791 (rank : 397)
Query Neighborhood Hits	531	Target Neighborhood Hits	168	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

TARA_HUMAN
θ value	0.0736092 (rank : 137)	NC score	0.166297 (rank : 118)
Query Neighborhood Hits	531	Target Neighborhood Hits	1626	Shared Neighborhood Hits	245
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TEC_HUMAN
θ value	0.0736092 (rank : 138)	NC score	0.114179 (rank : 262)
Query Neighborhood Hits	531	Target Neighborhood Hits	1006	Shared Neighborhood Hits	93
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

ASPP2_HUMAN
θ value	0.0961366 (rank : 139)	NC score	0.111972 (rank : 272)
Query Neighborhood Hits	531	Target Neighborhood Hits	1156	Shared Neighborhood Hits	149
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

AUTS2_HUMAN
θ value	0.0961366 (rank : 140)	NC score	0.122406 (rank : 234)
Query Neighborhood Hits	531	Target Neighborhood Hits	342	Shared Neighborhood Hits	95
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

BRD4_HUMAN
θ value	0.0961366 (rank : 141)	NC score	0.120616 (rank : 239)
Query Neighborhood Hits	531	Target Neighborhood Hits	851	Shared Neighborhood Hits	150
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

G3BP2_MOUSE
θ value	0.0961366 (rank : 142)	NC score	0.071674 (rank : 534)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	38
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

P85B_HUMAN
θ value	0.0961366 (rank : 143)	NC score	0.206436 (rank : 56)
Query Neighborhood Hits	531	Target Neighborhood Hits	543	Shared Neighborhood Hits	99
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PTN23_HUMAN
θ value	0.0961366 (rank : 144)	NC score	0.088556 (rank : 408)
Query Neighborhood Hits	531	Target Neighborhood Hits	646	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

SYP2L_HUMAN
θ value	0.0961366 (rank : 145)	NC score	0.085249 (rank : 426)
Query Neighborhood Hits	531	Target Neighborhood Hits	400	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

TRIP6_HUMAN
θ value	0.0961366 (rank : 146)	NC score	0.029238 (rank : 973)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	25
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

ARI1A_HUMAN
θ value	0.125558 (rank : 147)	NC score	0.190495 (rank : 77)
Query Neighborhood Hits	531	Target Neighborhood Hits	787	Shared Neighborhood Hits	178
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

CISH_MOUSE
θ value	0.125558 (rank : 148)	NC score	0.147685 (rank : 153)
Query Neighborhood Hits	531	Target Neighborhood Hits	94	Shared Neighborhood Hits	49
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

FA47A_HUMAN
θ value	0.125558 (rank : 149)	NC score	0.249713 (rank : 27)
Query Neighborhood Hits	531	Target Neighborhood Hits	451	Shared Neighborhood Hits	171
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FOXP4_MOUSE
θ value	0.125558 (rank : 150)	NC score	0.023853 (rank : 999)
Query Neighborhood Hits	531	Target Neighborhood Hits	211	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DBY0, Q80V92, Q8CG10, Q8CIS1	Gene names	Foxp4
Domain Architecture	No domain graphic available
Description	Forkhead box protein P4 (Fork head-related protein like A) (mFKHLA).

FYN_HUMAN
θ value	0.125558 (rank : 151)	NC score	0.115544 (rank : 258)
Query Neighborhood Hits	531	Target Neighborhood Hits	1078	Shared Neighborhood Hits	103
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.125558 (rank : 152)	NC score	0.117163 (rank : 255)
Query Neighborhood Hits	531	Target Neighborhood Hits	1073	Shared Neighborhood Hits	102
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

MLL3_HUMAN
θ value	0.125558 (rank : 153)	NC score	0.258024 (rank : 22)
Query Neighborhood Hits	531	Target Neighborhood Hits	1644	Shared Neighborhood Hits	294
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

PCGF2_MOUSE
θ value	0.125558 (rank : 154)	NC score	0.048432 (rank : 898)
Query Neighborhood Hits	531	Target Neighborhood Hits	213	Shared Neighborhood Hits	20
SwissProt Accessions	P23798	Gene names	Pcgf2, Mel-18, Mel18, Rnf110, Zfp144, Znf144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144).

PTN6_HUMAN
θ value	0.125558 (rank : 155)	NC score	0.131958 (rank : 204)
Query Neighborhood Hits	531	Target Neighborhood Hits	234	Shared Neighborhood Hits	75
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

TESK1_HUMAN
θ value	0.125558 (rank : 156)	NC score	0.048684 (rank : 897)
Query Neighborhood Hits	531	Target Neighborhood Hits	864	Shared Neighborhood Hits	58
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

TXK_MOUSE
θ value	0.125558 (rank : 157)	NC score	0.113251 (rank : 267)
Query Neighborhood Hits	531	Target Neighborhood Hits	980	Shared Neighborhood Hits	93
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

WASF2_HUMAN
θ value	0.125558 (rank : 158)	NC score	0.164604 (rank : 121)
Query Neighborhood Hits	531	Target Neighborhood Hits	280	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

BCL9_HUMAN
θ value	0.163984 (rank : 159)	NC score	0.267431 (rank : 18)
Query Neighborhood Hits	531	Target Neighborhood Hits	1008	Shared Neighborhood Hits	252
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

CO039_MOUSE
θ value	0.163984 (rank : 160)	NC score	0.179757 (rank : 89)
Query Neighborhood Hits	531	Target Neighborhood Hits	445	Shared Neighborhood Hits	162
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

HNRL1_HUMAN
θ value	0.163984 (rank : 161)	NC score	0.077812 (rank : 485)
Query Neighborhood Hits	531	Target Neighborhood Hits	173	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BUJ2, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75	Gene names	HNRPUL1, E1BAP5
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5).

IWS1_MOUSE
θ value	0.163984 (rank : 162)	NC score	0.158124 (rank : 134)
Query Neighborhood Hits	531	Target Neighborhood Hits	1258	Shared Neighborhood Hits	179
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MEF2B_MOUSE
θ value	0.163984 (rank : 163)	NC score	0.107580 (rank : 297)
Query Neighborhood Hits	531	Target Neighborhood Hits	218	Shared Neighborhood Hits	70
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

NSD1_MOUSE
θ value	0.163984 (rank : 164)	NC score	0.095439 (rank : 371)
Query Neighborhood Hits	531	Target Neighborhood Hits	472	Shared Neighborhood Hits	84
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

OBSCN_HUMAN
θ value	0.163984 (rank : 165)	NC score	0.059010 (rank : 668)
Query Neighborhood Hits	531	Target Neighborhood Hits	1931	Shared Neighborhood Hits	194
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

P85A_HUMAN
θ value	0.163984 (rank : 166)	NC score	0.185811 (rank : 80)
Query Neighborhood Hits	531	Target Neighborhood Hits	479	Shared Neighborhood Hits	81
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PO6F2_MOUSE
θ value	0.163984 (rank : 167)	NC score	0.058900 (rank : 671)
Query Neighborhood Hits	531	Target Neighborhood Hits	639	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

PRR8_HUMAN
θ value	0.163984 (rank : 168)	NC score	0.126596 (rank : 221)
Query Neighborhood Hits	531	Target Neighborhood Hits	217	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

SNPC4_HUMAN
θ value	0.163984 (rank : 169)	NC score	0.167597 (rank : 116)
Query Neighborhood Hits	531	Target Neighborhood Hits	589	Shared Neighborhood Hits	162
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SYNJ1_HUMAN
θ value	0.163984 (rank : 170)	NC score	0.100397 (rank : 336)
Query Neighborhood Hits	531	Target Neighborhood Hits	498	Shared Neighborhood Hits	140
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TEC_MOUSE
θ value	0.163984 (rank : 171)	NC score	0.111421 (rank : 277)
Query Neighborhood Hits	531	Target Neighborhood Hits	1006	Shared Neighborhood Hits	90
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

YES_MOUSE
θ value	0.163984 (rank : 172)	NC score	0.117165 (rank : 254)
Query Neighborhood Hits	531	Target Neighborhood Hits	1052	Shared Neighborhood Hits	100
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_MOUSE
θ value	0.163984 (rank : 173)	NC score	0.091151 (rank : 394)
Query Neighborhood Hits	531	Target Neighborhood Hits	905	Shared Neighborhood Hits	89
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

CISH_HUMAN
θ value	0.21417 (rank : 174)	NC score	0.145543 (rank : 163)
Query Neighborhood Hits	531	Target Neighborhood Hits	94	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

CRKL_MOUSE
θ value	0.21417 (rank : 175)	NC score	0.206164 (rank : 57)
Query Neighborhood Hits	531	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

GRB2_HUMAN
θ value	0.21417 (rank : 176)	NC score	0.229274 (rank : 41)
Query Neighborhood Hits	531	Target Neighborhood Hits	310	Shared Neighborhood Hits	90
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.21417 (rank : 177)	NC score	0.229713 (rank : 40)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	92
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

LEO1_MOUSE
θ value	0.21417 (rank : 178)	NC score	0.059349 (rank : 660)
Query Neighborhood Hits	531	Target Neighborhood Hits	946	Shared Neighborhood Hits	73
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

LTBP4_MOUSE
θ value	0.21417 (rank : 179)	NC score	0.019948 (rank : 1010)
Query Neighborhood Hits	531	Target Neighborhood Hits	607	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

PHF2_MOUSE
θ value	0.21417 (rank : 180)	NC score	0.046341 (rank : 908)
Query Neighborhood Hits	531	Target Neighborhood Hits	241	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTU0, Q80WA8	Gene names	Phf2
Domain Architecture
Description	PHD finger protein 2 (GRC5).

SHC1_HUMAN
θ value	0.21417 (rank : 181)	NC score	0.228910 (rank : 43)
Query Neighborhood Hits	531	Target Neighborhood Hits	170	Shared Neighborhood Hits	79
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SNIP_MOUSE
θ value	0.21417 (rank : 182)	NC score	0.077376 (rank : 486)
Query Neighborhood Hits	531	Target Neighborhood Hits	319	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

SP5_MOUSE
θ value	0.21417 (rank : 183)	NC score	0.010939 (rank : 1033)
Query Neighborhood Hits	531	Target Neighborhood Hits	821	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JHX2	Gene names	Sp5
Domain Architecture
Description	Transcription factor Sp5.

SREC2_MOUSE
θ value	0.21417 (rank : 184)	NC score	0.023741 (rank : 1000)
Query Neighborhood Hits	531	Target Neighborhood Hits	605	Shared Neighborhood Hits	57
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

T22D4_HUMAN
θ value	0.21417 (rank : 185)	NC score	0.169249 (rank : 112)
Query Neighborhood Hits	531	Target Neighborhood Hits	403	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

YES_HUMAN
θ value	0.21417 (rank : 186)	NC score	0.116929 (rank : 256)
Query Neighborhood Hits	531	Target Neighborhood Hits	1059	Shared Neighborhood Hits	101
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ZAP70_HUMAN
θ value	0.21417 (rank : 187)	NC score	0.089998 (rank : 401)
Query Neighborhood Hits	531	Target Neighborhood Hits	893	Shared Neighborhood Hits	91
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

ZC313_HUMAN
θ value	0.21417 (rank : 188)	NC score	0.070674 (rank : 540)
Query Neighborhood Hits	531	Target Neighborhood Hits	772	Shared Neighborhood Hits	64
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

ZN207_HUMAN
θ value	0.21417 (rank : 189)	NC score	0.128114 (rank : 214)
Query Neighborhood Hits	531	Target Neighborhood Hits	326	Shared Neighborhood Hits	56
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

AB1IP_HUMAN
θ value	0.279714 (rank : 190)	NC score	0.128048 (rank : 215)
Query Neighborhood Hits	531	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

CLCN1_HUMAN
θ value	0.279714 (rank : 191)	NC score	0.029269 (rank : 972)
Query Neighborhood Hits	531	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

DIAP1_HUMAN
θ value	0.279714 (rank : 192)	NC score	0.086425 (rank : 419)
Query Neighborhood Hits	531	Target Neighborhood Hits	784	Shared Neighborhood Hits	95
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

FGD1_MOUSE
θ value	0.279714 (rank : 193)	NC score	0.049972 (rank : 893)
Query Neighborhood Hits	531	Target Neighborhood Hits	387	Shared Neighborhood Hits	70
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

GLIS1_HUMAN
θ value	0.279714 (rank : 194)	NC score	0.002419 (rank : 1056)
Query Neighborhood Hits	531	Target Neighborhood Hits	748	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

GRB14_MOUSE
θ value	0.279714 (rank : 195)	NC score	0.179391 (rank : 92)
Query Neighborhood Hits	531	Target Neighborhood Hits	149	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

JPH2_MOUSE
θ value	0.279714 (rank : 196)	NC score	0.059622 (rank : 654)
Query Neighborhood Hits	531	Target Neighborhood Hits	279	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

P85B_MOUSE
θ value	0.279714 (rank : 197)	NC score	0.200696 (rank : 62)
Query Neighborhood Hits	531	Target Neighborhood Hits	519	Shared Neighborhood Hits	83
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PCQAP_MOUSE
θ value	0.279714 (rank : 198)	NC score	0.113006 (rank : 269)
Query Neighborhood Hits	531	Target Neighborhood Hits	506	Shared Neighborhood Hits	78
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

PER1_MOUSE
θ value	0.279714 (rank : 199)	NC score	0.055545 (rank : 775)
Query Neighborhood Hits	531	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

PHF2_HUMAN
θ value	0.279714 (rank : 200)	NC score	0.045589 (rank : 909)
Query Neighborhood Hits	531	Target Neighborhood Hits	208	Shared Neighborhood Hits	32
SwissProt Accessions	O75151, Q8N3K2, Q9Y6N4	Gene names	PHF2, KIAA0662
Domain Architecture
Description	PHD finger protein 2 (GRC5).

PI5PA_HUMAN
θ value	0.279714 (rank : 201)	NC score	0.164639 (rank : 120)
Query Neighborhood Hits	531	Target Neighborhood Hits	749	Shared Neighborhood Hits	209
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

RGS3_HUMAN
θ value	0.279714 (rank : 202)	NC score	0.210482 (rank : 54)
Query Neighborhood Hits	531	Target Neighborhood Hits	1375	Shared Neighborhood Hits	284
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RSMB_HUMAN
θ value	0.279714 (rank : 203)	NC score	0.059154 (rank : 666)
Query Neighborhood Hits	531	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	P14678, Q15490, Q9UIS5	Gene names	SNRPB, COD, SNRPB1
Domain Architecture
Description	Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/Sm-B') (SmB/SmB').

SC24A_MOUSE
θ value	0.279714 (rank : 204)	NC score	0.138337 (rank : 183)
Query Neighborhood Hits	531	Target Neighborhood Hits	394	Shared Neighborhood Hits	152
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

SGIP1_HUMAN
θ value	0.279714 (rank : 205)	NC score	0.100268 (rank : 338)
Query Neighborhood Hits	531	Target Neighborhood Hits	198	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SH21B_MOUSE
θ value	0.279714 (rank : 206)	NC score	0.222231 (rank : 46)
Query Neighborhood Hits	531	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SOCS2_HUMAN
θ value	0.279714 (rank : 207)	NC score	0.169095 (rank : 113)
Query Neighborhood Hits	531	Target Neighborhood Hits	104	Shared Neighborhood Hits	55
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

SOCS2_MOUSE
θ value	0.279714 (rank : 208)	NC score	0.170680 (rank : 110)
Query Neighborhood Hits	531	Target Neighborhood Hits	94	Shared Neighborhood Hits	55
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

SP5_HUMAN
θ value	0.279714 (rank : 209)	NC score	0.012985 (rank : 1028)
Query Neighborhood Hits	531	Target Neighborhood Hits	832	Shared Neighborhood Hits	79
SwissProt Accessions	Q6BEB4	Gene names	SP5
Domain Architecture	No domain graphic available
Description	Transcription factor Sp5.

TAB3_MOUSE
θ value	0.279714 (rank : 210)	NC score	0.119875 (rank : 242)
Query Neighborhood Hits	531	Target Neighborhood Hits	273	Shared Neighborhood Hits	82
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

YLPM1_MOUSE
θ value	0.279714 (rank : 211)	NC score	0.150324 (rank : 148)
Query Neighborhood Hits	531	Target Neighborhood Hits	505	Shared Neighborhood Hits	115
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

ACINU_MOUSE
θ value	0.365318 (rank : 212)	NC score	0.076147 (rank : 492)
Query Neighborhood Hits	531	Target Neighborhood Hits	712	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

BAT2_MOUSE
θ value	0.365318 (rank : 213)	NC score	0.196554 (rank : 68)
Query Neighborhood Hits	531	Target Neighborhood Hits	947	Shared Neighborhood Hits	230
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

ECM1_HUMAN
θ value	0.365318 (rank : 214)	NC score	0.127706 (rank : 217)
Query Neighborhood Hits	531	Target Neighborhood Hits	182	Shared Neighborhood Hits	76
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

FMN2_HUMAN
θ value	0.365318 (rank : 215)	NC score	0.119158 (rank : 245)
Query Neighborhood Hits	531	Target Neighborhood Hits	484	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

GGN_MOUSE
θ value	0.365318 (rank : 216)	NC score	0.148419 (rank : 151)
Query Neighborhood Hits	531	Target Neighborhood Hits	311	Shared Neighborhood Hits	88
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

HUWE1_MOUSE
θ value	0.365318 (rank : 217)	NC score	0.030584 (rank : 965)
Query Neighborhood Hits	531	Target Neighborhood Hits	406	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

PCGF2_HUMAN
θ value	0.365318 (rank : 218)	NC score	0.047443 (rank : 901)
Query Neighborhood Hits	531	Target Neighborhood Hits	222	Shared Neighborhood Hits	23
SwissProt Accessions	P35227	Gene names	PCGF2, MEL18, RNF110, ZNF144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144).

PCLO_MOUSE
θ value	0.365318 (rank : 219)	NC score	0.183440 (rank : 83)
Query Neighborhood Hits	531	Target Neighborhood Hits	2275	Shared Neighborhood Hits	324
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PRB3_HUMAN
θ value	0.365318 (rank : 220)	NC score	0.152701 (rank : 143)
Query Neighborhood Hits	531	Target Neighborhood Hits	318	Shared Neighborhood Hits	87
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

RPB1_HUMAN
θ value	0.365318 (rank : 221)	NC score	0.083755 (rank : 435)
Query Neighborhood Hits	531	Target Neighborhood Hits	362	Shared Neighborhood Hits	69
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	0.365318 (rank : 222)	NC score	0.084289 (rank : 430)
Query Neighborhood Hits	531	Target Neighborhood Hits	363	Shared Neighborhood Hits	68
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SF3A2_MOUSE
θ value	0.365318 (rank : 223)	NC score	0.142987 (rank : 175)
Query Neighborhood Hits	531	Target Neighborhood Hits	247	Shared Neighborhood Hits	81
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

STK39_MOUSE
θ value	0.365318 (rank : 224)	NC score	0.043143 (rank : 921)
Query Neighborhood Hits	531	Target Neighborhood Hits	915	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

ZO1_HUMAN
θ value	0.365318 (rank : 225)	NC score	0.059231 (rank : 664)
Query Neighborhood Hits	531	Target Neighborhood Hits	474	Shared Neighborhood Hits	100
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

ZYX_MOUSE
θ value	0.365318 (rank : 226)	NC score	0.053057 (rank : 825)
Query Neighborhood Hits	531	Target Neighborhood Hits	347	Shared Neighborhood Hits	62
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

ALEX_MOUSE
θ value	0.47712 (rank : 227)	NC score	0.101401 (rank : 331)
Query Neighborhood Hits	531	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

AMELX_HUMAN
θ value	0.47712 (rank : 228)	NC score	0.074399 (rank : 507)
Query Neighborhood Hits	531	Target Neighborhood Hits	95	Shared Neighborhood Hits	34
SwissProt Accessions	Q99217, Q96NW6, Q9UCA7	Gene names	AMELX, AMG, AMGX
Domain Architecture
Description	Amelogenin, X isoform precursor.

BAG3_MOUSE
θ value	0.47712 (rank : 229)	NC score	0.182441 (rank : 84)
Query Neighborhood Hits	531	Target Neighborhood Hits	513	Shared Neighborhood Hits	184
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

CD2L7_HUMAN
θ value	0.47712 (rank : 230)	NC score	0.049998 (rank : 892)
Query Neighborhood Hits	531	Target Neighborhood Hits	1275	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

FBX7_HUMAN
θ value	0.47712 (rank : 231)	NC score	0.052708 (rank : 833)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y3I1, Q5TGC4, Q96HM6, Q9UF21, Q9UKT2	Gene names	FBXO7, FBX7
Domain Architecture	No domain graphic available
Description	F-box only protein 7.

HXA3_MOUSE
θ value	0.47712 (rank : 232)	NC score	0.027432 (rank : 983)
Query Neighborhood Hits	531	Target Neighborhood Hits	558	Shared Neighborhood Hits	80
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

PO121_MOUSE
θ value	0.47712 (rank : 233)	NC score	0.094123 (rank : 378)
Query Neighborhood Hits	531	Target Neighborhood Hits	345	Shared Neighborhood Hits	70
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

SRBP1_MOUSE
θ value	0.47712 (rank : 234)	NC score	0.093898 (rank : 379)
Query Neighborhood Hits	531	Target Neighborhood Hits	384	Shared Neighborhood Hits	110
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

ADA19_HUMAN
θ value	0.62314 (rank : 235)	NC score	0.017338 (rank : 1018)
Query Neighborhood Hits	531	Target Neighborhood Hits	381	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

ASPP1_HUMAN
θ value	0.62314 (rank : 236)	NC score	0.094810 (rank : 375)
Query Neighborhood Hits	531	Target Neighborhood Hits	956	Shared Neighborhood Hits	110
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	0.62314 (rank : 237)	NC score	0.160638 (rank : 129)
Query Neighborhood Hits	531	Target Neighborhood Hits	1244	Shared Neighborhood Hits	221
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ATX7_HUMAN
θ value	0.62314 (rank : 238)	NC score	0.143133 (rank : 174)
Query Neighborhood Hits	531	Target Neighborhood Hits	351	Shared Neighborhood Hits	131
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

CRKL_HUMAN
θ value	0.62314 (rank : 239)	NC score	0.192749 (rank : 74)
Query Neighborhood Hits	531	Target Neighborhood Hits	313	Shared Neighborhood Hits	87
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CS007_HUMAN
θ value	0.62314 (rank : 240)	NC score	0.088072 (rank : 412)
Query Neighborhood Hits	531	Target Neighborhood Hits	401	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

DYN2_MOUSE
θ value	0.62314 (rank : 241)	NC score	0.037684 (rank : 943)
Query Neighborhood Hits	531	Target Neighborhood Hits	104	Shared Neighborhood Hits	23
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

FXL19_HUMAN
θ value	0.62314 (rank : 242)	NC score	0.042532 (rank : 923)
Query Neighborhood Hits	531	Target Neighborhood Hits	147	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

GNAS1_MOUSE
θ value	0.62314 (rank : 243)	NC score	0.096609 (rank : 361)
Query Neighborhood Hits	531	Target Neighborhood Hits	651	Shared Neighborhood Hits	153
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

INAR2_HUMAN
θ value	0.62314 (rank : 244)	NC score	0.036104 (rank : 948)
Query Neighborhood Hits	531	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P48551	Gene names	IFNAR2, IFNARB
Domain Architecture
Description	Interferon-alpha/beta receptor beta chain precursor (IFN-alpha-REC) (Type I interferon receptor) (IFN-R) (Interferon alpha/beta receptor 2).

KMHN1_MOUSE
θ value	0.62314 (rank : 245)	NC score	0.008512 (rank : 1040)
Query Neighborhood Hits	531	Target Neighborhood Hits	949	Shared Neighborhood Hits	34
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

LEO1_HUMAN
θ value	0.62314 (rank : 246)	NC score	0.058796 (rank : 672)
Query Neighborhood Hits	531	Target Neighborhood Hits	958	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

MAST4_HUMAN
θ value	0.62314 (rank : 247)	NC score	0.075975 (rank : 494)
Query Neighborhood Hits	531	Target Neighborhood Hits	1804	Shared Neighborhood Hits	251
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MBD5_HUMAN
θ value	0.62314 (rank : 248)	NC score	0.107211 (rank : 301)
Query Neighborhood Hits	531	Target Neighborhood Hits	176	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

MILK1_HUMAN
θ value	0.62314 (rank : 249)	NC score	0.081626 (rank : 453)
Query Neighborhood Hits	531	Target Neighborhood Hits	427	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

MNT_HUMAN
θ value	0.62314 (rank : 250)	NC score	0.121926 (rank : 237)
Query Neighborhood Hits	531	Target Neighborhood Hits	496	Shared Neighborhood Hits	129
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NCOR2_MOUSE
θ value	0.62314 (rank : 251)	NC score	0.095402 (rank : 372)
Query Neighborhood Hits	531	Target Neighborhood Hits	790	Shared Neighborhood Hits	129
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

P55G_HUMAN
θ value	0.62314 (rank : 252)	NC score	0.201727 (rank : 60)
Query Neighborhood Hits	531	Target Neighborhood Hits	451	Shared Neighborhood Hits	72
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	0.62314 (rank : 253)	NC score	0.200018 (rank : 64)
Query Neighborhood Hits	531	Target Neighborhood Hits	401	Shared Neighborhood Hits	69
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85A_MOUSE
θ value	0.62314 (rank : 254)	NC score	0.189083 (rank : 78)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	81
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PHAR2_HUMAN
θ value	0.62314 (rank : 255)	NC score	0.062344 (rank : 619)
Query Neighborhood Hits	531	Target Neighborhood Hits	208	Shared Neighborhood Hits	32
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

ROBO1_HUMAN
θ value	0.62314 (rank : 256)	NC score	0.020367 (rank : 1008)
Query Neighborhood Hits	531	Target Neighborhood Hits	529	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

WHRN_MOUSE
θ value	0.62314 (rank : 257)	NC score	0.047639 (rank : 900)
Query Neighborhood Hits	531	Target Neighborhood Hits	412	Shared Neighborhood Hits	74
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

YLPM1_HUMAN
θ value	0.62314 (rank : 258)	NC score	0.160832 (rank : 128)
Query Neighborhood Hits	531	Target Neighborhood Hits	670	Shared Neighborhood Hits	152
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ARID2_HUMAN
θ value	0.813845 (rank : 259)	NC score	0.091708 (rank : 392)
Query Neighborhood Hits	531	Target Neighborhood Hits	302	Shared Neighborhood Hits	61
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

CO5A1_HUMAN
θ value	0.813845 (rank : 260)	NC score	0.034253 (rank : 950)
Query Neighborhood Hits	531	Target Neighborhood Hits	434	Shared Neighborhood Hits	62
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

DYN2_HUMAN
θ value	0.813845 (rank : 261)	NC score	0.040580 (rank : 932)
Query Neighborhood Hits	531	Target Neighborhood Hits	112	Shared Neighborhood Hits	32
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

ITK_HUMAN
θ value	0.813845 (rank : 262)	NC score	0.106324 (rank : 304)
Query Neighborhood Hits	531	Target Neighborhood Hits	1016	Shared Neighborhood Hits	91
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MAP1A_HUMAN
θ value	0.813845 (rank : 263)	NC score	0.124914 (rank : 224)
Query Neighborhood Hits	531	Target Neighborhood Hits	1626	Shared Neighborhood Hits	222
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MYO15_HUMAN
θ value	0.813845 (rank : 264)	NC score	0.076060 (rank : 493)
Query Neighborhood Hits	531	Target Neighborhood Hits	671	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MYPN_HUMAN
θ value	0.813845 (rank : 265)	NC score	0.038445 (rank : 939)
Query Neighborhood Hits	531	Target Neighborhood Hits	418	Shared Neighborhood Hits	32
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

NELFA_MOUSE
θ value	0.813845 (rank : 266)	NC score	0.082254 (rank : 446)
Query Neighborhood Hits	531	Target Neighborhood Hits	195	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9	Gene names	Whsc2, Nelfa, Whsc2h
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2).

PRCC_HUMAN
θ value	0.813845 (rank : 267)	NC score	0.088108 (rank : 411)
Query Neighborhood Hits	531	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q92733, O00665, O00724	Gene names	PRCC, TPRC
Domain Architecture	No domain graphic available
Description	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein).

PS1C2_MOUSE
θ value	0.813845 (rank : 268)	NC score	0.116647 (rank : 257)
Query Neighborhood Hits	531	Target Neighborhood Hits	59	Shared Neighborhood Hits	20
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

RBM6_HUMAN
θ value	0.813845 (rank : 269)	NC score	0.045333 (rank : 911)
Query Neighborhood Hits	531	Target Neighborhood Hits	221	Shared Neighborhood Hits	24
SwissProt Accessions	P78332, O60549, O75524	Gene names	RBM6, DEF3
Domain Architecture
Description	RNA-binding protein 6 (RNA-binding motif protein 6) (RNA-binding protein DEF-3) (Lung cancer antigen NY-LU-12) (Protein G16).

SASH1_HUMAN
θ value	0.813845 (rank : 270)	NC score	0.062100 (rank : 622)
Query Neighborhood Hits	531	Target Neighborhood Hits	292	Shared Neighborhood Hits	65
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SETBP_MOUSE
θ value	0.813845 (rank : 271)	NC score	0.096420 (rank : 364)
Query Neighborhood Hits	531	Target Neighborhood Hits	352	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SOCS6_HUMAN
θ value	0.813845 (rank : 272)	NC score	0.146223 (rank : 158)
Query Neighborhood Hits	531	Target Neighborhood Hits	126	Shared Neighborhood Hits	53
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

SOCS6_MOUSE
θ value	0.813845 (rank : 273)	NC score	0.150437 (rank : 147)
Query Neighborhood Hits	531	Target Neighborhood Hits	146	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

TAU_MOUSE
θ value	0.813845 (rank : 274)	NC score	0.111897 (rank : 273)
Query Neighborhood Hits	531	Target Neighborhood Hits	502	Shared Neighborhood Hits	125
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TNIK_HUMAN
θ value	0.813845 (rank : 275)	NC score	0.041563 (rank : 928)
Query Neighborhood Hits	531	Target Neighborhood Hits	1570	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

TRAK2_HUMAN
θ value	0.813845 (rank : 276)	NC score	0.020520 (rank : 1007)
Query Neighborhood Hits	531	Target Neighborhood Hits	476	Shared Neighborhood Hits	14
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

ZIC5_HUMAN
θ value	0.813845 (rank : 277)	NC score	0.002236 (rank : 1059)
Query Neighborhood Hits	531	Target Neighborhood Hits	774	Shared Neighborhood Hits	48
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

AFF1_HUMAN
θ value	1.06291 (rank : 278)	NC score	0.124310 (rank : 225)
Query Neighborhood Hits	531	Target Neighborhood Hits	506	Shared Neighborhood Hits	97
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

ATX2_HUMAN
θ value	1.06291 (rank : 279)	NC score	0.084719 (rank : 428)
Query Neighborhood Hits	531	Target Neighborhood Hits	375	Shared Neighborhood Hits	97
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

DLX3_MOUSE
θ value	1.06291 (rank : 280)	NC score	0.005066 (rank : 1052)
Query Neighborhood Hits	531	Target Neighborhood Hits	367	Shared Neighborhood Hits	11
SwissProt Accessions	Q64205	Gene names	Dlx3
Domain Architecture
Description	Homeobox protein DLX-3.

FOG1_MOUSE
θ value	1.06291 (rank : 281)	NC score	0.040974 (rank : 929)
Query Neighborhood Hits	531	Target Neighborhood Hits	1237	Shared Neighborhood Hits	159
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

HRG_HUMAN
θ value	1.06291 (rank : 282)	NC score	0.039760 (rank : 934)
Query Neighborhood Hits	531	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	P04196	Gene names	HRG
Domain Architecture
Description	Histidine-rich glycoprotein precursor (Histidine-proline-rich glycoprotein) (HPRG).

ITK_MOUSE
θ value	1.06291 (rank : 283)	NC score	0.106260 (rank : 305)
Query Neighborhood Hits	531	Target Neighborhood Hits	985	Shared Neighborhood Hits	89
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

M3K11_HUMAN
θ value	1.06291 (rank : 284)	NC score	0.068787 (rank : 563)
Query Neighborhood Hits	531	Target Neighborhood Hits	1136	Shared Neighborhood Hits	110
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

MNAB_HUMAN
θ value	1.06291 (rank : 285)	NC score	0.032009 (rank : 960)
Query Neighborhood Hits	531	Target Neighborhood Hits	196	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

NFH_HUMAN
θ value	1.06291 (rank : 286)	NC score	0.047245 (rank : 904)
Query Neighborhood Hits	531	Target Neighborhood Hits	1242	Shared Neighborhood Hits	111
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NFM_HUMAN
θ value	1.06291 (rank : 287)	NC score	0.030134 (rank : 966)
Query Neighborhood Hits	531	Target Neighborhood Hits	1328	Shared Neighborhood Hits	120
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

PO121_HUMAN
θ value	1.06291 (rank : 288)	NC score	0.096985 (rank : 358)
Query Neighborhood Hits	531	Target Neighborhood Hits	344	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

PYR1_HUMAN
θ value	1.06291 (rank : 289)	NC score	0.043103 (rank : 922)
Query Neighborhood Hits	531	Target Neighborhood Hits	119	Shared Neighborhood Hits	28
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

RAI1_HUMAN
θ value	1.06291 (rank : 290)	NC score	0.083664 (rank : 436)
Query Neighborhood Hits	531	Target Neighborhood Hits	360	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

UBP6_HUMAN
θ value	1.06291 (rank : 291)	NC score	0.025261 (rank : 992)
Query Neighborhood Hits	531	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

UBP8_HUMAN
θ value	1.06291 (rank : 292)	NC score	0.023191 (rank : 1001)
Query Neighborhood Hits	531	Target Neighborhood Hits	751	Shared Neighborhood Hits	64
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

ZCH14_HUMAN
θ value	1.06291 (rank : 293)	NC score	0.065147 (rank : 600)
Query Neighborhood Hits	531	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WYQ9, O60324, Q9UFP0	Gene names	ZCCHC14, KIAA0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

B3A3_HUMAN
θ value	1.38821 (rank : 294)	NC score	0.015645 (rank : 1024)
Query Neighborhood Hits	531	Target Neighborhood Hits	119	Shared Neighborhood Hits	23
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

CCD45_MOUSE
θ value	1.38821 (rank : 295)	NC score	0.051220 (rank : 865)
Query Neighborhood Hits	531	Target Neighborhood Hits	663	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

CRK_HUMAN
θ value	1.38821 (rank : 296)	NC score	0.197248 (rank : 67)
Query Neighborhood Hits	531	Target Neighborhood Hits	308	Shared Neighborhood Hits	87
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	1.38821 (rank : 297)	NC score	0.195672 (rank : 70)
Query Neighborhood Hits	531	Target Neighborhood Hits	314	Shared Neighborhood Hits	90
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAAM2_MOUSE
θ value	1.38821 (rank : 298)	NC score	0.054372 (rank : 803)
Query Neighborhood Hits	531	Target Neighborhood Hits	371	Shared Neighborhood Hits	38
SwissProt Accessions	Q80U19, Q810J5	Gene names	Daam2, Kiaa0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DYN1_HUMAN
θ value	1.38821 (rank : 299)	NC score	0.053542 (rank : 817)
Query Neighborhood Hits	531	Target Neighborhood Hits	216	Shared Neighborhood Hits	53
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

ENAH_HUMAN
θ value	1.38821 (rank : 300)	NC score	0.069108 (rank : 557)
Query Neighborhood Hits	531	Target Neighborhood Hits	784	Shared Neighborhood Hits	101
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

K1688_HUMAN
θ value	1.38821 (rank : 301)	NC score	0.075298 (rank : 498)
Query Neighborhood Hits	531	Target Neighborhood Hits	217	Shared Neighborhood Hits	57
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

MNT_MOUSE
θ value	1.38821 (rank : 302)	NC score	0.099438 (rank : 347)
Query Neighborhood Hits	531	Target Neighborhood Hits	432	Shared Neighborhood Hits	85
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

NCOR2_HUMAN
θ value	1.38821 (rank : 303)	NC score	0.107418 (rank : 298)
Query Neighborhood Hits	531	Target Neighborhood Hits	870	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

RC3H1_HUMAN
θ value	1.38821 (rank : 304)	NC score	0.089645 (rank : 403)
Query Neighborhood Hits	531	Target Neighborhood Hits	433	Shared Neighborhood Hits	109
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

RTN4_MOUSE
θ value	1.38821 (rank : 305)	NC score	0.067055 (rank : 579)
Query Neighborhood Hits	531	Target Neighborhood Hits	341	Shared Neighborhood Hits	73
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

SF3B4_HUMAN
θ value	1.38821 (rank : 306)	NC score	0.056690 (rank : 747)
Query Neighborhood Hits	531	Target Neighborhood Hits	445	Shared Neighborhood Hits	73
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

SH21A_MOUSE
θ value	1.38821 (rank : 307)	NC score	0.201349 (rank : 61)
Query Neighborhood Hits	531	Target Neighborhood Hits	89	Shared Neighborhood Hits	53
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SMCA4_HUMAN
θ value	1.38821 (rank : 308)	NC score	0.043413 (rank : 920)
Query Neighborhood Hits	531	Target Neighborhood Hits	597	Shared Neighborhood Hits	96
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

SMRC2_MOUSE
θ value	1.38821 (rank : 309)	NC score	0.070563 (rank : 542)
Query Neighborhood Hits	531	Target Neighborhood Hits	487	Shared Neighborhood Hits	90
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SOCS7_MOUSE
θ value	1.38821 (rank : 310)	NC score	0.155014 (rank : 137)
Query Neighborhood Hits	531	Target Neighborhood Hits	154	Shared Neighborhood Hits	66
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SOX11_MOUSE
θ value	1.38821 (rank : 311)	NC score	0.019806 (rank : 1013)
Query Neighborhood Hits	531	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q7M6Y2, O35178, O89036, Q04889, Q80XF0	Gene names	Sox11, Sox-11
Domain Architecture	No domain graphic available
Description	Transcription factor SOX-11.

SOX8_HUMAN
θ value	1.38821 (rank : 312)	NC score	0.018781 (rank : 1016)
Query Neighborhood Hits	531	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	P57073, Q9NZW2	Gene names	SOX8
Domain Architecture
Description	Transcription factor SOX-8.

ZCHC8_HUMAN
θ value	1.38821 (rank : 313)	NC score	0.039625 (rank : 935)
Query Neighborhood Hits	531	Target Neighborhood Hits	92	Shared Neighborhood Hits	16
SwissProt Accessions	Q6NZY4, Q7L2P6, Q8N2K5, Q96SK7, Q9NSS2, Q9NSS3	Gene names	ZCCHC8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

ZN509_MOUSE
θ value	1.38821 (rank : 314)	NC score	0.000261 (rank : 1063)
Query Neighborhood Hits	531	Target Neighborhood Hits	990	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

ZN516_MOUSE
θ value	1.38821 (rank : 315)	NC score	0.038059 (rank : 940)
Query Neighborhood Hits	531	Target Neighborhood Hits	1197	Shared Neighborhood Hits	160
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

CBP_MOUSE
θ value	1.81305 (rank : 316)	NC score	0.175408 (rank : 100)
Query Neighborhood Hits	531	Target Neighborhood Hits	1051	Shared Neighborhood Hits	216
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CD2_HUMAN
θ value	1.81305 (rank : 317)	NC score	0.207751 (rank : 55)
Query Neighborhood Hits	531	Target Neighborhood Hits	504	Shared Neighborhood Hits	178
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

CEP35_HUMAN
θ value	1.81305 (rank : 318)	NC score	0.037567 (rank : 944)
Query Neighborhood Hits	531	Target Neighborhood Hits	811	Shared Neighborhood Hits	64
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

DAB1_MOUSE
θ value	1.81305 (rank : 319)	NC score	0.066911 (rank : 582)
Query Neighborhood Hits	531	Target Neighborhood Hits	145	Shared Neighborhood Hits	48
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

GAB1_MOUSE
θ value	1.81305 (rank : 320)	NC score	0.102491 (rank : 322)
Query Neighborhood Hits	531	Target Neighborhood Hits	233	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAK2_HUMAN
θ value	1.81305 (rank : 321)	NC score	0.099571 (rank : 343)
Query Neighborhood Hits	531	Target Neighborhood Hits	406	Shared Neighborhood Hits	155
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK3_HUMAN
θ value	1.81305 (rank : 322)	NC score	0.054400 (rank : 801)
Query Neighborhood Hits	531	Target Neighborhood Hits	182	Shared Neighborhood Hits	72
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK5_HUMAN
θ value	1.81305 (rank : 323)	NC score	0.103288 (rank : 318)
Query Neighborhood Hits	531	Target Neighborhood Hits	429	Shared Neighborhood Hits	163
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GGA3_MOUSE
θ value	1.81305 (rank : 324)	NC score	0.029825 (rank : 969)
Query Neighborhood Hits	531	Target Neighborhood Hits	148	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

JADE2_HUMAN
θ value	1.81305 (rank : 325)	NC score	0.033108 (rank : 956)
Query Neighborhood Hits	531	Target Neighborhood Hits	199	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

MYPN_MOUSE
θ value	1.81305 (rank : 326)	NC score	0.040776 (rank : 931)
Query Neighborhood Hits	531	Target Neighborhood Hits	421	Shared Neighborhood Hits	34
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

MYST3_HUMAN
θ value	1.81305 (rank : 327)	NC score	0.062964 (rank : 613)
Query Neighborhood Hits	531	Target Neighborhood Hits	772	Shared Neighborhood Hits	106
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

NSD1_HUMAN
θ value	1.81305 (rank : 328)	NC score	0.100799 (rank : 334)
Query Neighborhood Hits	531	Target Neighborhood Hits	427	Shared Neighborhood Hits	81
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

PO6F2_HUMAN
θ value	1.81305 (rank : 329)	NC score	0.057625 (rank : 710)
Query Neighborhood Hits	531	Target Neighborhood Hits	618	Shared Neighborhood Hits	91
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

PRP2_MOUSE
θ value	1.81305 (rank : 330)	NC score	0.164479 (rank : 123)
Query Neighborhood Hits	531	Target Neighborhood Hits	347	Shared Neighborhood Hits	94
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

SMAD9_HUMAN
θ value	1.81305 (rank : 331)	NC score	0.039390 (rank : 936)
Query Neighborhood Hits	531	Target Neighborhood Hits	48	Shared Neighborhood Hits	10
SwissProt Accessions	O15198, O14989	Gene names	SMAD9, MADH6, MADH9
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Madh6).

TARSH_HUMAN
θ value	1.81305 (rank : 332)	NC score	0.240172 (rank : 33)
Query Neighborhood Hits	531	Target Neighborhood Hits	768	Shared Neighborhood Hits	231
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

ALEX_HUMAN
θ value	2.36792 (rank : 333)	NC score	0.153584 (rank : 141)
Query Neighborhood Hits	531	Target Neighborhood Hits	361	Shared Neighborhood Hits	107
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

ANTOL_MOUSE
θ value	2.36792 (rank : 334)	NC score	0.034125 (rank : 951)
Query Neighborhood Hits	531	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D8N6	Gene names
Domain Architecture	No domain graphic available
Description	Antolefinin (Antolefinine).

BASP_HUMAN
θ value	2.36792 (rank : 335)	NC score	0.099521 (rank : 344)
Query Neighborhood Hits	531	Target Neighborhood Hits	321	Shared Neighborhood Hits	55
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BASP_MOUSE
θ value	2.36792 (rank : 336)	NC score	0.098605 (rank : 352)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	46
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

BCAR1_HUMAN
θ value	2.36792 (rank : 337)	NC score	0.161428 (rank : 127)
Query Neighborhood Hits	531	Target Neighborhood Hits	554	Shared Neighborhood Hits	184
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BIN1_MOUSE
θ value	2.36792 (rank : 338)	NC score	0.056267 (rank : 755)
Query Neighborhood Hits	531	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CRSP7_HUMAN
θ value	2.36792 (rank : 339)	NC score	0.082456 (rank : 443)
Query Neighborhood Hits	531	Target Neighborhood Hits	247	Shared Neighborhood Hits	67
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

ELL2_HUMAN
θ value	2.36792 (rank : 340)	NC score	0.024889 (rank : 993)
Query Neighborhood Hits	531	Target Neighborhood Hits	77	Shared Neighborhood Hits	13
SwissProt Accessions	O00472	Gene names	ELL2
Domain Architecture
Description	RNA polymerase II elongation factor ELL2.

FIP1_HUMAN
θ value	2.36792 (rank : 341)	NC score	0.051942 (rank : 853)
Query Neighborhood Hits	531	Target Neighborhood Hits	118	Shared Neighborhood Hits	25
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

FIP1_MOUSE
θ value	2.36792 (rank : 342)	NC score	0.050461 (rank : 882)
Query Neighborhood Hits	531	Target Neighborhood Hits	120	Shared Neighborhood Hits	24
SwissProt Accessions	Q9D824, Q8BWX7, Q99LH0, Q9DBB2	Gene names	Fip1l1
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1).

FZD8_MOUSE
θ value	2.36792 (rank : 343)	NC score	0.005512 (rank : 1051)
Query Neighborhood Hits	531	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q61091	Gene names	Fzd8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (mFz8).

GSCR1_HUMAN
θ value	2.36792 (rank : 344)	NC score	0.151707 (rank : 145)
Query Neighborhood Hits	531	Target Neighborhood Hits	674	Shared Neighborhood Hits	167
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

LTBP2_HUMAN
θ value	2.36792 (rank : 345)	NC score	0.009170 (rank : 1038)
Query Neighborhood Hits	531	Target Neighborhood Hits	552	Shared Neighborhood Hits	32
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MINK1_HUMAN
θ value	2.36792 (rank : 346)	NC score	0.044112 (rank : 914)
Query Neighborhood Hits	531	Target Neighborhood Hits	1477	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

MYO15_MOUSE
θ value	2.36792 (rank : 347)	NC score	0.051594 (rank : 859)
Query Neighborhood Hits	531	Target Neighborhood Hits	467	Shared Neighborhood Hits	140
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

OXRP_HUMAN
θ value	2.36792 (rank : 348)	NC score	0.027523 (rank : 981)
Query Neighborhood Hits	531	Target Neighborhood Hits	544	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

PKN3_HUMAN
θ value	2.36792 (rank : 349)	NC score	0.027980 (rank : 978)
Query Neighborhood Hits	531	Target Neighborhood Hits	893	Shared Neighborhood Hits	52
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

PROL1_HUMAN
θ value	2.36792 (rank : 350)	NC score	0.042128 (rank : 925)
Query Neighborhood Hits	531	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q99935	Gene names	PROL1, BPLP
Domain Architecture	No domain graphic available
Description	Proline-rich protein 1 precursor (PRL1) (Basic proline-rich lacrimal protein).

RILP_MOUSE
θ value	2.36792 (rank : 351)	NC score	0.024294 (rank : 995)
Query Neighborhood Hits	531	Target Neighborhood Hits	257	Shared Neighborhood Hits	7
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

S23IP_MOUSE
θ value	2.36792 (rank : 352)	NC score	0.099470 (rank : 346)
Query Neighborhood Hits	531	Target Neighborhood Hits	363	Shared Neighborhood Hits	116
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

SLIK5_MOUSE
θ value	2.36792 (rank : 353)	NC score	0.001952 (rank : 1060)
Query Neighborhood Hits	531	Target Neighborhood Hits	301	Shared Neighborhood Hits	10
SwissProt Accessions	Q810B7, Q9CT21	Gene names	Slitrk5
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor.

SNIP_HUMAN
θ value	2.36792 (rank : 354)	NC score	0.064251 (rank : 605)
Query Neighborhood Hits	531	Target Neighborhood Hits	313	Shared Neighborhood Hits	49
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

STK39_HUMAN
θ value	2.36792 (rank : 355)	NC score	0.041691 (rank : 927)
Query Neighborhood Hits	531	Target Neighborhood Hits	882	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

ULK1_MOUSE
θ value	2.36792 (rank : 356)	NC score	0.070150 (rank : 548)
Query Neighborhood Hits	531	Target Neighborhood Hits	1214	Shared Neighborhood Hits	190
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

WDR19_HUMAN
θ value	2.36792 (rank : 357)	NC score	0.027410 (rank : 984)
Query Neighborhood Hits	531	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEZ3, Q8N5B4, Q9H5S0, Q9HCD4	Gene names	WDR19, KIAA1638
Domain Architecture	No domain graphic available
Description	WD repeat protein 19.

WDR19_MOUSE
θ value	2.36792 (rank : 358)	NC score	0.027448 (rank : 982)
Query Neighborhood Hits	531	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UGF1, Q6ZPK8, Q80VQ6, Q8C794, Q8K3R5	Gene names	Wdr19, Kiaa1638
Domain Architecture	No domain graphic available
Description	WD repeat protein 19.

WNK4_HUMAN
θ value	2.36792 (rank : 359)	NC score	0.044104 (rank : 915)
Query Neighborhood Hits	531	Target Neighborhood Hits	1043	Shared Neighborhood Hits	103
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

ZAN_MOUSE
θ value	2.36792 (rank : 360)	NC score	0.024202 (rank : 996)
Query Neighborhood Hits	531	Target Neighborhood Hits	808	Shared Neighborhood Hits	40
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ACK1_HUMAN
θ value	3.0926 (rank : 361)	NC score	0.092288 (rank : 388)
Query Neighborhood Hits	531	Target Neighborhood Hits	1140	Shared Neighborhood Hits	173
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ANX11_HUMAN
θ value	3.0926 (rank : 362)	NC score	0.032195 (rank : 958)
Query Neighborhood Hits	531	Target Neighborhood Hits	192	Shared Neighborhood Hits	53
SwissProt Accessions	P50995	Gene names	ANXA11, ANX11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50) (56 kDa autoantigen).

BIN1_HUMAN
θ value	3.0926 (rank : 363)	NC score	0.070647 (rank : 541)
Query Neighborhood Hits	531	Target Neighborhood Hits	335	Shared Neighborhood Hits	69
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

CAC1A_MOUSE
θ value	3.0926 (rank : 364)	NC score	0.017071 (rank : 1019)
Query Neighborhood Hits	531	Target Neighborhood Hits	267	Shared Neighborhood Hits	49
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CECR2_HUMAN
θ value	3.0926 (rank : 365)	NC score	0.144107 (rank : 171)
Query Neighborhood Hits	531	Target Neighborhood Hits	543	Shared Neighborhood Hits	145
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CT151_HUMAN
θ value	3.0926 (rank : 366)	NC score	0.078964 (rank : 470)
Query Neighborhood Hits	531	Target Neighborhood Hits	382	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

DPOLL_MOUSE
θ value	3.0926 (rank : 367)	NC score	0.023872 (rank : 998)
Query Neighborhood Hits	531	Target Neighborhood Hits	71	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXE2, Q9CTJ1	Gene names	Poll, Polk
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa).

FER_HUMAN
θ value	3.0926 (rank : 368)	NC score	0.095894 (rank : 367)
Query Neighborhood Hits	531	Target Neighborhood Hits	1278	Shared Neighborhood Hits	108
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FOXN1_HUMAN
θ value	3.0926 (rank : 369)	NC score	0.062696 (rank : 614)
Query Neighborhood Hits	531	Target Neighborhood Hits	377	Shared Neighborhood Hits	107
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

GGA1_MOUSE
θ value	3.0926 (rank : 370)	NC score	0.027272 (rank : 987)
Query Neighborhood Hits	531	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

IQEC2_HUMAN
θ value	3.0926 (rank : 371)	NC score	0.049337 (rank : 895)
Query Neighborhood Hits	531	Target Neighborhood Hits	403	Shared Neighborhood Hits	87
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IQEC2_MOUSE
θ value	3.0926 (rank : 372)	NC score	0.051006 (rank : 871)
Query Neighborhood Hits	531	Target Neighborhood Hits	417	Shared Neighborhood Hits	88
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

IRS2_HUMAN
θ value	3.0926 (rank : 373)	NC score	0.055336 (rank : 781)
Query Neighborhood Hits	531	Target Neighborhood Hits	262	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

KCT2_HUMAN
θ value	3.0926 (rank : 374)	NC score	0.026619 (rank : 989)
Query Neighborhood Hits	531	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NC54, Q9NRG2	Gene names	KCT2, C5orf15
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated transmembrane protein 2 precursor.

MINT_HUMAN
θ value	3.0926 (rank : 375)	NC score	0.094810 (rank : 374)
Query Neighborhood Hits	531	Target Neighborhood Hits	1291	Shared Neighborhood Hits	180
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MUCDL_MOUSE
θ value	3.0926 (rank : 376)	NC score	0.054082 (rank : 809)
Query Neighborhood Hits	531	Target Neighborhood Hits	461	Shared Neighborhood Hits	76
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

PRGC2_HUMAN
θ value	3.0926 (rank : 377)	NC score	0.064217 (rank : 606)
Query Neighborhood Hits	531	Target Neighborhood Hits	272	Shared Neighborhood Hits	70
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

RILP_HUMAN
θ value	3.0926 (rank : 378)	NC score	0.032298 (rank : 957)
Query Neighborhood Hits	531	Target Neighborhood Hits	249	Shared Neighborhood Hits	18
SwissProt Accessions	Q96NA2, Q71RE6, Q9BSL3, Q9BYS3	Gene names	RILP
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

RIN3_MOUSE
θ value	3.0926 (rank : 379)	NC score	0.063912 (rank : 610)
Query Neighborhood Hits	531	Target Neighborhood Hits	239	Shared Neighborhood Hits	73
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

SCAP_HUMAN
θ value	3.0926 (rank : 380)	NC score	0.032081 (rank : 959)
Query Neighborhood Hits	531	Target Neighborhood Hits	368	Shared Neighborhood Hits	60
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

SH21A_HUMAN
θ value	3.0926 (rank : 381)	NC score	0.195777 (rank : 69)
Query Neighborhood Hits	531	Target Neighborhood Hits	89	Shared Neighborhood Hits	54
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH23A_HUMAN
θ value	3.0926 (rank : 382)	NC score	0.120079 (rank : 241)
Query Neighborhood Hits	531	Target Neighborhood Hits	149	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

SN1L2_HUMAN
θ value	3.0926 (rank : 383)	NC score	0.042318 (rank : 924)
Query Neighborhood Hits	531	Target Neighborhood Hits	964	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

SN1L2_MOUSE
θ value	3.0926 (rank : 384)	NC score	0.040933 (rank : 930)
Query Neighborhood Hits	531	Target Neighborhood Hits	944	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

VINC_HUMAN
θ value	3.0926 (rank : 385)	NC score	0.017836 (rank : 1017)
Query Neighborhood Hits	531	Target Neighborhood Hits	145	Shared Neighborhood Hits	16
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

WASP_MOUSE
θ value	3.0926 (rank : 386)	NC score	0.149425 (rank : 150)
Query Neighborhood Hits	531	Target Neighborhood Hits	223	Shared Neighborhood Hits	78
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

ZCH14_MOUSE
θ value	3.0926 (rank : 387)	NC score	0.067738 (rank : 574)
Query Neighborhood Hits	531	Target Neighborhood Hits	109	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VIG0, Q80TX3, Q91VU4	Gene names	Zcchc14, Kiaa0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

ACRO_HUMAN
θ value	4.03905 (rank : 388)	NC score	0.006809 (rank : 1049)
Query Neighborhood Hits	531	Target Neighborhood Hits	291	Shared Neighborhood Hits	52
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

AFF4_HUMAN
θ value	4.03905 (rank : 389)	NC score	0.072860 (rank : 523)
Query Neighborhood Hits	531	Target Neighborhood Hits	611	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

AP2A1_HUMAN
θ value	4.03905 (rank : 390)	NC score	0.010272 (rank : 1035)
Query Neighborhood Hits	531	Target Neighborhood Hits	56	Shared Neighborhood Hits	10
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

ARHGF_HUMAN
θ value	4.03905 (rank : 391)	NC score	0.053549 (rank : 816)
Query Neighborhood Hits	531	Target Neighborhood Hits	214	Shared Neighborhood Hits	56
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

BC11A_HUMAN
θ value	4.03905 (rank : 392)	NC score	0.001583 (rank : 1061)
Query Neighborhood Hits	531	Target Neighborhood Hits	745	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H165, Q86W14, Q8WU92, Q96JL6, Q9H163, Q9H164, Q9H3G9, Q9NWA7	Gene names	BCL11A, CTIP1, EVI9, KIAA1809
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A) (COUP-TF- interacting protein 1) (Ecotropic viral integration site 9 protein) (EVI-9).

BC11A_MOUSE
θ value	4.03905 (rank : 393)	NC score	0.002311 (rank : 1058)
Query Neighborhood Hits	531	Target Neighborhood Hits	732	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QYE3, Q80T89, Q8BLC7, Q8BLR4, Q8BWX3, Q921V4, Q9D0V2, Q9JIT4, Q9JLK8, Q9JLK9	Gene names	Bcl11a, Ctip1, Evi9, Kiaa1809
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A) (COUP-TF- interacting protein 1) (Ecotropic viral integration site 9 protein) (EVI-9).

CA106_HUMAN
θ value	4.03905 (rank : 394)	NC score	0.030870 (rank : 963)
Query Neighborhood Hits	531	Target Neighborhood Hits	124	Shared Neighborhood Hits	24
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

CI040_HUMAN
θ value	4.03905 (rank : 395)	NC score	0.025384 (rank : 991)
Query Neighborhood Hits	531	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IXQ3, Q9NWD3	Gene names	C9orf40
Domain Architecture	No domain graphic available
Description	Protein C9orf40.

DAB1_HUMAN
θ value	4.03905 (rank : 396)	NC score	0.100320 (rank : 337)
Query Neighborhood Hits	531	Target Neighborhood Hits	219	Shared Neighborhood Hits	82
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

ELOA3_HUMAN
θ value	4.03905 (rank : 397)	NC score	0.047309 (rank : 903)
Query Neighborhood Hits	531	Target Neighborhood Hits	98	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

ENL_HUMAN
θ value	4.03905 (rank : 398)	NC score	0.083158 (rank : 439)
Query Neighborhood Hits	531	Target Neighborhood Hits	305	Shared Neighborhood Hits	60
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

ERRFI_MOUSE
θ value	4.03905 (rank : 399)	NC score	0.043631 (rank : 917)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

FOG1_HUMAN
θ value	4.03905 (rank : 400)	NC score	0.022327 (rank : 1004)
Query Neighborhood Hits	531	Target Neighborhood Hits	981	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

GRB14_HUMAN
θ value	4.03905 (rank : 401)	NC score	0.164579 (rank : 122)
Query Neighborhood Hits	531	Target Neighborhood Hits	137	Shared Neighborhood Hits	65
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

HS105_HUMAN
θ value	4.03905 (rank : 402)	NC score	0.015837 (rank : 1021)
Query Neighborhood Hits	531	Target Neighborhood Hits	209	Shared Neighborhood Hits	29
SwissProt Accessions	Q92598, O95739, Q5TBM6, Q5TBM8, Q9UPC4	Gene names	HSPH1, HSP105, HSP110, KIAA0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock 110 kDa protein) (Antigen NY- CO-25).

HXD3_MOUSE
θ value	4.03905 (rank : 403)	NC score	0.007925 (rank : 1044)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	34
SwissProt Accessions	P09027, Q3UUD3	Gene names	Hoxd3, Hox-4.1, Hoxd-3
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4.1) (Homeobox protein MH-19).

IASPP_HUMAN
θ value	4.03905 (rank : 404)	NC score	0.110849 (rank : 284)
Query Neighborhood Hits	531	Target Neighborhood Hits	688	Shared Neighborhood Hits	138
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

INCE_HUMAN
θ value	4.03905 (rank : 405)	NC score	0.024561 (rank : 994)
Query Neighborhood Hits	531	Target Neighborhood Hits	978	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

K1949_MOUSE
θ value	4.03905 (rank : 406)	NC score	0.047078 (rank : 906)
Query Neighborhood Hits	531	Target Neighborhood Hits	134	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

KIF9_HUMAN
θ value	4.03905 (rank : 407)	NC score	0.002532 (rank : 1055)
Query Neighborhood Hits	531	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HAQ2, Q86Z28, Q9H8A4	Gene names	KIF9
Domain Architecture
Description	Kinesin-like protein KIF9.

LR37A_HUMAN
θ value	4.03905 (rank : 408)	NC score	0.101726 (rank : 330)
Query Neighborhood Hits	531	Target Neighborhood Hits	720	Shared Neighborhood Hits	122
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

MECP2_MOUSE
θ value	4.03905 (rank : 409)	NC score	0.029859 (rank : 968)
Query Neighborhood Hits	531	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z2D6	Gene names	Mecp2
Domain Architecture
Description	Methyl-CpG-binding protein 2 (MeCP-2 protein) (MeCP2).

NAF1_HUMAN
θ value	4.03905 (rank : 410)	NC score	0.019698 (rank : 1015)
Query Neighborhood Hits	531	Target Neighborhood Hits	937	Shared Neighborhood Hits	53
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

NFAC2_MOUSE
θ value	4.03905 (rank : 411)	NC score	0.026276 (rank : 990)
Query Neighborhood Hits	531	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q60591, Q60984, Q60985	Gene names	Nfatc2, Nfat1, Nfatp
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

PDC6I_HUMAN
θ value	4.03905 (rank : 412)	NC score	0.078659 (rank : 474)
Query Neighborhood Hits	531	Target Neighborhood Hits	278	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

PER1_HUMAN
θ value	4.03905 (rank : 413)	NC score	0.047200 (rank : 905)
Query Neighborhood Hits	531	Target Neighborhood Hits	215	Shared Neighborhood Hits	46
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

PKHA4_HUMAN
θ value	4.03905 (rank : 414)	NC score	0.054189 (rank : 806)
Query Neighborhood Hits	531	Target Neighborhood Hits	283	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PUM2_HUMAN
θ value	4.03905 (rank : 415)	NC score	0.013026 (rank : 1027)
Query Neighborhood Hits	531	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TB72, O00234, Q53TV7, Q8WY43, Q9HAN2	Gene names	PUM2, KIAA0235, PUMH2
Domain Architecture
Description	Pumilio homolog 2 (Pumilio-2).

RAI1_MOUSE
θ value	4.03905 (rank : 416)	NC score	0.085217 (rank : 427)
Query Neighborhood Hits	531	Target Neighborhood Hits	344	Shared Neighborhood Hits	81
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

SEM6C_HUMAN
θ value	4.03905 (rank : 417)	NC score	0.005926 (rank : 1050)
Query Neighborhood Hits	531	Target Neighborhood Hits	117	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3T2, Q5JR71, Q8WXT8, Q8WXT9, Q8WXU0, Q96JF8	Gene names	SEMA6C, KIAA1869, SEMAY
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

SMAD1_HUMAN
θ value	4.03905 (rank : 418)	NC score	0.043430 (rank : 919)
Query Neighborhood Hits	531	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	Q15797, Q16636	Gene names	SMAD1, BSP1, MADH1, MADR1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Transforming growth factor- beta signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

SON_HUMAN
θ value	4.03905 (rank : 419)	NC score	0.244691 (rank : 30)
Query Neighborhood Hits	531	Target Neighborhood Hits	1568	Shared Neighborhood Hits	300
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

SOX30_MOUSE
θ value	4.03905 (rank : 420)	NC score	0.069084 (rank : 560)
Query Neighborhood Hits	531	Target Neighborhood Hits	374	Shared Neighborhood Hits	115
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

SOX9_HUMAN
θ value	4.03905 (rank : 421)	NC score	0.029822 (rank : 970)
Query Neighborhood Hits	531	Target Neighborhood Hits	210	Shared Neighborhood Hits	47
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

TEAD2_HUMAN
θ value	4.03905 (rank : 422)	NC score	0.012413 (rank : 1030)
Query Neighborhood Hits	531	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q15562, Q96IG3	Gene names	TEAD2, TEF4
Domain Architecture
Description	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2).

ZN703_HUMAN
θ value	4.03905 (rank : 423)	NC score	0.038049 (rank : 941)
Query Neighborhood Hits	531	Target Neighborhood Hits	154	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H7S9, Q5XG76	Gene names	ZNF703
Domain Architecture	No domain graphic available
Description	Zinc finger protein 703.

3BP1_MOUSE
θ value	5.27518 (rank : 424)	NC score	0.045394 (rank : 910)
Query Neighborhood Hits	531	Target Neighborhood Hits	238	Shared Neighborhood Hits	51
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ABI1_HUMAN
θ value	5.27518 (rank : 425)	NC score	0.075551 (rank : 496)
Query Neighborhood Hits	531	Target Neighborhood Hits	257	Shared Neighborhood Hits	68
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

AFF4_MOUSE
θ value	5.27518 (rank : 426)	NC score	0.074833 (rank : 503)
Query Neighborhood Hits	531	Target Neighborhood Hits	581	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

ANKS6_MOUSE
θ value	5.27518 (rank : 427)	NC score	0.027982 (rank : 977)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	37
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

BCOR_MOUSE
θ value	5.27518 (rank : 428)	NC score	0.037522 (rank : 945)
Query Neighborhood Hits	531	Target Neighborhood Hits	521	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

C2TA_HUMAN
θ value	5.27518 (rank : 429)	NC score	0.038971 (rank : 938)
Query Neighborhood Hits	531	Target Neighborhood Hits	190	Shared Neighborhood Hits	54
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

CBP_HUMAN
θ value	5.27518 (rank : 430)	NC score	0.150690 (rank : 146)
Query Neighborhood Hits	531	Target Neighborhood Hits	941	Shared Neighborhood Hits	196
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CCDC4_HUMAN
θ value	5.27518 (rank : 431)	NC score	0.035574 (rank : 949)
Query Neighborhood Hits	531	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

CI005_HUMAN
θ value	5.27518 (rank : 432)	NC score	0.019875 (rank : 1011)
Query Neighborhood Hits	531	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H330, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6	Gene names	C9orf5
Domain Architecture	No domain graphic available
Description	Protein C9orf5 (Protein CG-2).

ETV6_HUMAN
θ value	5.27518 (rank : 433)	NC score	0.027744 (rank : 980)
Query Neighborhood Hits	531	Target Neighborhood Hits	120	Shared Neighborhood Hits	32
SwissProt Accessions	P41212, Q9UMF6	Gene names	ETV6, TEL, TEL1
Domain Architecture
Description	Transcription factor ETV6 (ETS-related protein Tel1) (Tel) (ETS translocation variant 6).

FA47B_HUMAN
θ value	5.27518 (rank : 434)	NC score	0.231944 (rank : 37)
Query Neighborhood Hits	531	Target Neighborhood Hits	431	Shared Neighborhood Hits	163
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

GAB1_HUMAN
θ value	5.27518 (rank : 435)	NC score	0.104076 (rank : 314)
Query Neighborhood Hits	531	Target Neighborhood Hits	279	Shared Neighborhood Hits	106
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAK11_HUMAN
θ value	5.27518 (rank : 436)	NC score	0.099355 (rank : 348)
Query Neighborhood Hits	531	Target Neighborhood Hits	409	Shared Neighborhood Hits	158
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK12_HUMAN
θ value	5.27518 (rank : 437)	NC score	0.090942 (rank : 395)
Query Neighborhood Hits	531	Target Neighborhood Hits	374	Shared Neighborhood Hits	147
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK1_HUMAN
θ value	5.27518 (rank : 438)	NC score	0.071127 (rank : 537)
Query Neighborhood Hits	531	Target Neighborhood Hits	268	Shared Neighborhood Hits	111
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GAK4_HUMAN
θ value	5.27518 (rank : 439)	NC score	0.100160 (rank : 339)
Query Neighborhood Hits	531	Target Neighborhood Hits	415	Shared Neighborhood Hits	160
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

HES7_MOUSE
θ value	5.27518 (rank : 440)	NC score	0.020534 (rank : 1006)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

KLC4_HUMAN
θ value	5.27518 (rank : 441)	NC score	0.007425 (rank : 1045)
Query Neighborhood Hits	531	Target Neighborhood Hits	327	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NSK0	Gene names	KLC4, KNSL8
Domain Architecture
Description	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8).

MAP1B_MOUSE
θ value	5.27518 (rank : 442)	NC score	0.072688 (rank : 526)
Query Neighborhood Hits	531	Target Neighborhood Hits	977	Shared Neighborhood Hits	112
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

NCOR1_MOUSE
θ value	5.27518 (rank : 443)	NC score	0.053471 (rank : 818)
Query Neighborhood Hits	531	Target Neighborhood Hits	521	Shared Neighborhood Hits	71
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

NFAC1_HUMAN
θ value	5.27518 (rank : 444)	NC score	0.065300 (rank : 599)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	93
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

PAIP1_HUMAN
θ value	5.27518 (rank : 445)	NC score	0.029926 (rank : 967)
Query Neighborhood Hits	531	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H074, O60455, Q96B61, Q9BS63	Gene names	PAIP1
Domain Architecture
Description	Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1) (PABP-interacting protein 1) (PAIP-1).

PGCA_HUMAN
θ value	5.27518 (rank : 446)	NC score	0.030831 (rank : 964)
Query Neighborhood Hits	531	Target Neighborhood Hits	821	Shared Neighborhood Hits	77
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

PHF3_HUMAN
θ value	5.27518 (rank : 447)	NC score	0.039100 (rank : 937)
Query Neighborhood Hits	531	Target Neighborhood Hits	419	Shared Neighborhood Hits	47
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

PHLPP_MOUSE
θ value	5.27518 (rank : 448)	NC score	0.006974 (rank : 1048)
Query Neighborhood Hits	531	Target Neighborhood Hits	394	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

SAPS1_MOUSE
θ value	5.27518 (rank : 449)	NC score	0.027313 (rank : 985)
Query Neighborhood Hits	531	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

SET1A_HUMAN
θ value	5.27518 (rank : 450)	NC score	0.150188 (rank : 149)
Query Neighborhood Hits	531	Target Neighborhood Hits	690	Shared Neighborhood Hits	128
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

SETBP_HUMAN
θ value	5.27518 (rank : 451)	NC score	0.081979 (rank : 449)
Query Neighborhood Hits	531	Target Neighborhood Hits	305	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SHD_HUMAN
θ value	5.27518 (rank : 452)	NC score	0.135314 (rank : 195)
Query Neighborhood Hits	531	Target Neighborhood Hits	204	Shared Neighborhood Hits	87
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SIN3A_HUMAN
θ value	5.27518 (rank : 453)	NC score	0.037710 (rank : 942)
Query Neighborhood Hits	531	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

SIN3A_MOUSE
θ value	5.27518 (rank : 454)	NC score	0.031978 (rank : 962)
Query Neighborhood Hits	531	Target Neighborhood Hits	169	Shared Neighborhood Hits	40
SwissProt Accessions	Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2	Gene names	Sin3a
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

SYNPO_HUMAN
θ value	5.27518 (rank : 455)	NC score	0.085959 (rank : 421)
Query Neighborhood Hits	531	Target Neighborhood Hits	281	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TIAM1_MOUSE
θ value	5.27518 (rank : 456)	NC score	0.015689 (rank : 1023)
Query Neighborhood Hits	531	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TULP4_MOUSE
θ value	5.27518 (rank : 457)	NC score	0.036786 (rank : 946)
Query Neighborhood Hits	531	Target Neighborhood Hits	247	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JIL5, Q8CA75, Q922C2	Gene names	Tulp4, Tusp
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

UB7I1_HUMAN
θ value	5.27518 (rank : 458)	NC score	0.027995 (rank : 976)
Query Neighborhood Hits	531	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

UB7I1_MOUSE
θ value	5.27518 (rank : 459)	NC score	0.046937 (rank : 907)
Query Neighborhood Hits	531	Target Neighborhood Hits	206	Shared Neighborhood Hits	50
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

UBP34_HUMAN
θ value	5.27518 (rank : 460)	NC score	0.012795 (rank : 1029)
Query Neighborhood Hits	531	Target Neighborhood Hits	210	Shared Neighborhood Hits	19
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

XRCC1_HUMAN
θ value	5.27518 (rank : 461)	NC score	0.028364 (rank : 975)
Query Neighborhood Hits	531	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	P18887, Q9HCB1	Gene names	XRCC1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

ZBP1_HUMAN
θ value	5.27518 (rank : 462)	NC score	0.020034 (rank : 1009)
Query Neighborhood Hits	531	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H171, Q5JY39, Q9BYW4	Gene names	ZBP1, C20orf183, DLM1
Domain Architecture
Description	Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1).

AMELY_HUMAN
θ value	6.88961 (rank : 463)	NC score	0.044992 (rank : 912)
Query Neighborhood Hits	531	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	Q99218, Q6RWT1	Gene names	AMELY, AMGL, AMGY
Domain Architecture
Description	Amelogenin, Y isoform precursor.

ANTOL_HUMAN
θ value	6.88961 (rank : 464)	NC score	0.027839 (rank : 979)
Query Neighborhood Hits	531	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q96GY3, O14557, Q7Z2T9	Gene names	ames=MSTP064
Domain Architecture	No domain graphic available
Description	Antolefinin.

ATBF1_MOUSE
θ value	6.88961 (rank : 465)	NC score	0.033946 (rank : 953)
Query Neighborhood Hits	531	Target Neighborhood Hits	1841	Shared Neighborhood Hits	154
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

BAZ2A_HUMAN
θ value	6.88961 (rank : 466)	NC score	0.079145 (rank : 468)
Query Neighborhood Hits	531	Target Neighborhood Hits	780	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

CAC1B_HUMAN
θ value	6.88961 (rank : 467)	NC score	0.011754 (rank : 1032)
Query Neighborhood Hits	531	Target Neighborhood Hits	257	Shared Neighborhood Hits	32
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CBLB_HUMAN
θ value	6.88961 (rank : 468)	NC score	0.022445 (rank : 1003)
Query Neighborhood Hits	531	Target Neighborhood Hits	261	Shared Neighborhood Hits	35
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CSPG2_MOUSE
θ value	6.88961 (rank : 469)	NC score	0.016982 (rank : 1020)
Query Neighborhood Hits	531	Target Neighborhood Hits	711	Shared Neighborhood Hits	48
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

CSPG3_MOUSE
θ value	6.88961 (rank : 470)	NC score	0.012394 (rank : 1031)
Query Neighborhood Hits	531	Target Neighborhood Hits	657	Shared Neighborhood Hits	51
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

DOT1L_HUMAN
θ value	6.88961 (rank : 471)	NC score	0.080823 (rank : 461)
Query Neighborhood Hits	531	Target Neighborhood Hits	660	Shared Neighborhood Hits	108
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

EGR1_HUMAN
θ value	6.88961 (rank : 472)	NC score	-0.001973 (rank : 1064)
Query Neighborhood Hits	531	Target Neighborhood Hits	788	Shared Neighborhood Hits	31
SwissProt Accessions	P18146	Gene names	EGR1, ZNF225
Domain Architecture
Description	Early growth response protein 1 (EGR-1) (Krox-24 protein) (Transcription factor Zif268) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Zinc finger protein 225) (AT225).

ELK3_HUMAN
θ value	6.88961 (rank : 473)	NC score	0.004641 (rank : 1053)
Query Neighborhood Hits	531	Target Neighborhood Hits	64	Shared Neighborhood Hits	7
SwissProt Accessions	P41970, Q6FG57, Q6GU29, Q9UD17	Gene names	ELK3, NET, SAP2
Domain Architecture
Description	ETS domain-containing protein Elk-3 (ETS-related protein NET) (ETS- related protein ERP) (SRF accessory protein 2) (SAP-2).

ERRFI_HUMAN
θ value	6.88961 (rank : 474)	NC score	0.041913 (rank : 926)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJM3, Q9NTG9, Q9UD05	Gene names	ERRFI1, MIG6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (Mig-6).

GAK6_HUMAN
θ value	6.88961 (rank : 475)	NC score	0.095793 (rank : 369)
Query Neighborhood Hits	531	Target Neighborhood Hits	392	Shared Neighborhood Hits	153
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

JPH2_HUMAN
θ value	6.88961 (rank : 476)	NC score	0.114975 (rank : 260)
Query Neighborhood Hits	531	Target Neighborhood Hits	639	Shared Neighborhood Hits	173
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

K0460_HUMAN
θ value	6.88961 (rank : 477)	NC score	0.050469 (rank : 881)
Query Neighborhood Hits	531	Target Neighborhood Hits	357	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

LR37B_HUMAN
θ value	6.88961 (rank : 478)	NC score	0.029058 (rank : 974)
Query Neighborhood Hits	531	Target Neighborhood Hits	392	Shared Neighborhood Hits	46
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

MAP4_HUMAN
θ value	6.88961 (rank : 479)	NC score	0.106839 (rank : 302)
Query Neighborhood Hits	531	Target Neighborhood Hits	428	Shared Neighborhood Hits	109
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

NFAC2_HUMAN
θ value	6.88961 (rank : 480)	NC score	0.029529 (rank : 971)
Query Neighborhood Hits	531	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

NOLC1_HUMAN
θ value	6.88961 (rank : 481)	NC score	0.095758 (rank : 370)
Query Neighborhood Hits	531	Target Neighborhood Hits	452	Shared Neighborhood Hits	75
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NU153_HUMAN
θ value	6.88961 (rank : 482)	NC score	0.044955 (rank : 913)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	46
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

PAIRB_HUMAN
θ value	6.88961 (rank : 483)	NC score	0.031988 (rank : 961)
Query Neighborhood Hits	531	Target Neighborhood Hits	27	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NC51, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3	Gene names	SERBP1, PAIRBP1
Domain Architecture	No domain graphic available
Description	Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1).

PAK4_HUMAN
θ value	6.88961 (rank : 484)	NC score	0.033712 (rank : 954)
Query Neighborhood Hits	531	Target Neighborhood Hits	924	Shared Neighborhood Hits	65
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

RBBP6_HUMAN
θ value	6.88961 (rank : 485)	NC score	0.068017 (rank : 570)
Query Neighborhood Hits	531	Target Neighborhood Hits	1135	Shared Neighborhood Hits	127
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RBM15_HUMAN
θ value	6.88961 (rank : 486)	NC score	0.043655 (rank : 916)
Query Neighborhood Hits	531	Target Neighborhood Hits	309	Shared Neighborhood Hits	36
SwissProt Accessions	Q96T37, Q5D058, Q96PE4, Q96SC5, Q96SC6, Q96SC9, Q96SD0, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0	Gene names	RBM15, OTT
Domain Architecture
Description	Putative RNA-binding protein 15 (RNA-binding motif protein 15) (One- twenty two protein).

ROBO3_HUMAN
θ value	6.88961 (rank : 487)	NC score	0.019785 (rank : 1014)
Query Neighborhood Hits	531	Target Neighborhood Hits	570	Shared Neighborhood Hits	41
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

SF3B2_HUMAN
θ value	6.88961 (rank : 488)	NC score	0.047357 (rank : 902)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

SMR1_MOUSE
θ value	6.88961 (rank : 489)	NC score	0.079393 (rank : 467)
Query Neighborhood Hits	531	Target Neighborhood Hits	103	Shared Neighborhood Hits	44
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

SSBP3_HUMAN
θ value	6.88961 (rank : 490)	NC score	0.058582 (rank : 678)
Query Neighborhood Hits	531	Target Neighborhood Hits	132	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BWW4, Q9BTM0, Q9BWW3	Gene names	SSBP3, SSDP, SSDP1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein).

SSBP3_MOUSE
θ value	6.88961 (rank : 491)	NC score	0.058582 (rank : 679)
Query Neighborhood Hits	531	Target Neighborhood Hits	132	Shared Neighborhood Hits	49
SwissProt Accessions	Q9D032, Q99LC6, Q9EQP3	Gene names	Ssbp3, Last, Ssdp1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein) (Lck-associated signal transducer).

STAP2_MOUSE
θ value	6.88961 (rank : 492)	NC score	0.027305 (rank : 986)
Query Neighborhood Hits	531	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

SYNJ1_MOUSE
θ value	6.88961 (rank : 493)	NC score	0.104073 (rank : 315)
Query Neighborhood Hits	531	Target Neighborhood Hits	516	Shared Neighborhood Hits	153
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

T2FA_HUMAN
θ value	6.88961 (rank : 494)	NC score	0.048209 (rank : 899)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	28
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

TGON2_HUMAN
θ value	6.88961 (rank : 495)	NC score	0.151835 (rank : 144)
Query Neighborhood Hits	531	Target Neighborhood Hits	1037	Shared Neighborhood Hits	164
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

US6NL_MOUSE
θ value	6.88961 (rank : 496)	NC score	0.033955 (rank : 952)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q80XC3, Q6ZQK8	Gene names	Usp6nl, Kiaa0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein.

VAV3_MOUSE
θ value	6.88961 (rank : 497)	NC score	0.146066 (rank : 161)
Query Neighborhood Hits	531	Target Neighborhood Hits	404	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

WASF3_HUMAN
θ value	6.88961 (rank : 498)	NC score	0.137167 (rank : 190)
Query Neighborhood Hits	531	Target Neighborhood Hits	204	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

ZHX3_MOUSE
θ value	6.88961 (rank : 499)	NC score	0.008399 (rank : 1041)
Query Neighborhood Hits	531	Target Neighborhood Hits	321	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0Q2, Q80U14	Gene names	Zhx3, Kiaa0395, Tix1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

AFF2_MOUSE
θ value	8.99809 (rank : 500)	NC score	0.072660 (rank : 527)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

ANTR2_MOUSE
θ value	8.99809 (rank : 501)	NC score	0.007204 (rank : 1047)
Query Neighborhood Hits	531	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q6DFX2, Q99L17	Gene names	Antxr2
Domain Architecture	No domain graphic available
Description	Anthrax toxin receptor 2 precursor.

ATBF1_HUMAN
θ value	8.99809 (rank : 502)	NC score	0.023911 (rank : 997)
Query Neighborhood Hits	531	Target Neighborhood Hits	1547	Shared Neighborhood Hits	113
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

ATS12_MOUSE
θ value	8.99809 (rank : 503)	NC score	0.000300 (rank : 1062)
Query Neighborhood Hits	531	Target Neighborhood Hits	220	Shared Neighborhood Hits	8
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

BAT2_HUMAN
θ value	8.99809 (rank : 504)	NC score	0.182307 (rank : 85)
Query Neighborhood Hits	531	Target Neighborhood Hits	931	Shared Neighborhood Hits	226
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

CABL2_MOUSE
θ value	8.99809 (rank : 505)	NC score	0.022461 (rank : 1002)
Query Neighborhood Hits	531	Target Neighborhood Hits	79	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

CAC1G_HUMAN
θ value	8.99809 (rank : 506)	NC score	0.073437 (rank : 520)
Query Neighborhood Hits	531	Target Neighborhood Hits	587	Shared Neighborhood Hits	157
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CD6_HUMAN
θ value	8.99809 (rank : 507)	NC score	0.007420 (rank : 1046)
Query Neighborhood Hits	531	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

CN155_HUMAN
θ value	8.99809 (rank : 508)	NC score	0.120081 (rank : 240)
Query Neighborhood Hits	531	Target Neighborhood Hits	385	Shared Neighborhood Hits	90
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CO8A_HUMAN
θ value	8.99809 (rank : 509)	NC score	0.004312 (rank : 1054)
Query Neighborhood Hits	531	Target Neighborhood Hits	200	Shared Neighborhood Hits	8
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

COHA1_HUMAN
θ value	8.99809 (rank : 510)	NC score	0.040486 (rank : 933)
Query Neighborhood Hits	531	Target Neighborhood Hits	400	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

DDEF1_MOUSE
θ value	8.99809 (rank : 511)	NC score	0.051367 (rank : 862)
Query Neighborhood Hits	531	Target Neighborhood Hits	592	Shared Neighborhood Hits	102
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDHD1_HUMAN
θ value	8.99809 (rank : 512)	NC score	0.014528 (rank : 1025)
Query Neighborhood Hits	531	Target Neighborhood Hits	40	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NEL9, Q8WVH3, Q96LL2, Q9C0F8	Gene names	DDHD1, KIAA1705
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).

E2F2_HUMAN
θ value	8.99809 (rank : 513)	NC score	0.008002 (rank : 1043)
Query Neighborhood Hits	531	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q14209	Gene names	E2F2
Domain Architecture
Description	Transcription factor E2F2 (E2F-2).

EPN1_MOUSE
θ value	8.99809 (rank : 514)	NC score	0.049422 (rank : 894)
Query Neighborhood Hits	531	Target Neighborhood Hits	240	Shared Neighborhood Hits	74
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

FOXJ3_HUMAN
θ value	8.99809 (rank : 515)	NC score	0.009201 (rank : 1037)
Query Neighborhood Hits	531	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

ITCH_HUMAN
θ value	8.99809 (rank : 516)	NC score	0.009096 (rank : 1039)
Query Neighborhood Hits	531	Target Neighborhood Hits	162	Shared Neighborhood Hits	21
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

KCNN3_MOUSE
θ value	8.99809 (rank : 517)	NC score	0.008222 (rank : 1042)
Query Neighborhood Hits	531	Target Neighborhood Hits	171	Shared Neighborhood Hits	18
SwissProt Accessions	P58391	Gene names	Kcnn3, Sk3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3).

LRP10_MOUSE
θ value	8.99809 (rank : 518)	NC score	0.002333 (rank : 1057)
Query Neighborhood Hits	531	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQH7, Q7TS95, Q921T0, Q9EPE8	Gene names	Lrp10, Lrp9
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

MICA1_MOUSE
θ value	8.99809 (rank : 519)	NC score	0.010634 (rank : 1034)
Query Neighborhood Hits	531	Target Neighborhood Hits	400	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

NAT6_MOUSE
θ value	8.99809 (rank : 520)	NC score	0.022191 (rank : 1005)
Query Neighborhood Hits	531	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R123, Q8QZY5, Q8R014, Q9ERM0	Gene names	Nat6, Fus2
Domain Architecture
Description	N-acetyltransferase 6 (EC 2.3.1.-) (Fus-2 protein) (Fusion 2 protein).

PK1L1_HUMAN
θ value	8.99809 (rank : 521)	NC score	0.027054 (rank : 988)
Query Neighborhood Hits	531	Target Neighborhood Hits	140	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

RTN4_HUMAN
θ value	8.99809 (rank : 522)	NC score	0.070156 (rank : 547)
Query Neighborhood Hits	531	Target Neighborhood Hits	357	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SEC63_MOUSE
θ value	8.99809 (rank : 523)	NC score	0.019845 (rank : 1012)
Query Neighborhood Hits	531	Target Neighborhood Hits	601	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SHAN2_HUMAN
θ value	8.99809 (rank : 524)	NC score	0.060689 (rank : 639)
Query Neighborhood Hits	531	Target Neighborhood Hits	346	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SMR3A_HUMAN
θ value	8.99809 (rank : 525)	NC score	0.104859 (rank : 311)
Query Neighborhood Hits	531	Target Neighborhood Hits	93	Shared Neighborhood Hits	41
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

SYN3_HUMAN
θ value	8.99809 (rank : 526)	NC score	0.043579 (rank : 918)
Query Neighborhood Hits	531	Target Neighborhood Hits	203	Shared Neighborhood Hits	55
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

TEAD3_HUMAN
θ value	8.99809 (rank : 527)	NC score	0.009708 (rank : 1036)
Query Neighborhood Hits	531	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q99594, O95910, Q8N6Y4	Gene names	TEAD3, TEF5
Domain Architecture
Description	Transcriptional enhancer factor TEF-5 (TEA domain family member 3) (TEAD-3) (DTEF-1).

TROAP_HUMAN
θ value	8.99809 (rank : 528)	NC score	0.111118 (rank : 281)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	89
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

TTLL5_HUMAN
θ value	8.99809 (rank : 529)	NC score	0.015784 (rank : 1022)
Query Neighborhood Hits	531	Target Neighborhood Hits	141	Shared Neighborhood Hits	28
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

UBN1_HUMAN
θ value	8.99809 (rank : 530)	NC score	0.033278 (rank : 955)
Query Neighborhood Hits	531	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

ZN217_HUMAN
θ value	8.99809 (rank : 531)	NC score	0.014514 (rank : 1026)
Query Neighborhood Hits	531	Target Neighborhood Hits	905	Shared Neighborhood Hits	90
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

3BP2_MOUSE
θ value	θ > 10 (rank : 532)	NC score	0.073829 (rank : 512)
Query Neighborhood Hits	531	Target Neighborhood Hits	142	Shared Neighborhood Hits	40
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

AAK1_HUMAN
θ value	θ > 10 (rank : 533)	NC score	0.054672 (rank : 795)
Query Neighborhood Hits	531	Target Neighborhood Hits	1077	Shared Neighborhood Hits	146
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

AATK_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.090726 (rank : 398)
Query Neighborhood Hits	531	Target Neighborhood Hits	1243	Shared Neighborhood Hits	186
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AATK_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.069092 (rank : 558)
Query Neighborhood Hits	531	Target Neighborhood Hits	942	Shared Neighborhood Hits	83
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

ABI1_MOUSE
θ value	θ > 10 (rank : 536)	NC score	0.067680 (rank : 575)
Query Neighborhood Hits	531	Target Neighborhood Hits	246	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 537)	NC score	0.100034 (rank : 342)
Query Neighborhood Hits	531	Target Neighborhood Hits	350	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 538)	NC score	0.080338 (rank : 462)
Query Neighborhood Hits	531	Target Neighborhood Hits	266	Shared Neighborhood Hits	61
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 539)	NC score	0.082080 (rank : 448)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	72
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 540)	NC score	0.074343 (rank : 509)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL1_HUMAN
θ value	θ > 10 (rank : 541)	NC score	0.108898 (rank : 289)
Query Neighborhood Hits	531	Target Neighborhood Hits	1220	Shared Neighborhood Hits	137
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 542)	NC score	0.111522 (rank : 276)
Query Neighborhood Hits	531	Target Neighborhood Hits	1178	Shared Neighborhood Hits	141
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 543)	NC score	0.105976 (rank : 307)
Query Neighborhood Hits	531	Target Neighborhood Hits	1045	Shared Neighborhood Hits	110
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ACINU_HUMAN
θ value	θ > 10 (rank : 544)	NC score	0.078201 (rank : 479)
Query Neighborhood Hits	531	Target Neighborhood Hits	828	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

ACK1_MOUSE
θ value	θ > 10 (rank : 545)	NC score	0.085944 (rank : 422)
Query Neighborhood Hits	531	Target Neighborhood Hits	1080	Shared Neighborhood Hits	153
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

AFF2_HUMAN
θ value	θ > 10 (rank : 546)	NC score	0.068917 (rank : 561)
Query Neighborhood Hits	531	Target Neighborhood Hits	218	Shared Neighborhood Hits	59
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

AHI1_HUMAN
θ value	θ > 10 (rank : 547)	NC score	0.070277 (rank : 546)
Query Neighborhood Hits	531	Target Neighborhood Hits	537	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	θ > 10 (rank : 548)	NC score	0.060619 (rank : 640)
Query Neighborhood Hits	531	Target Neighborhood Hits	496	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

AKA12_HUMAN
θ value	θ > 10 (rank : 549)	NC score	0.050347 (rank : 884)
Query Neighborhood Hits	531	Target Neighborhood Hits	825	Shared Neighborhood Hits	84
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

AL2S4_MOUSE
θ value	θ > 10 (rank : 550)	NC score	0.054785 (rank : 791)
Query Neighborhood Hits	531	Target Neighborhood Hits	193	Shared Neighborhood Hits	58
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

ALK_HUMAN
θ value	θ > 10 (rank : 551)	NC score	0.061470 (rank : 631)
Query Neighborhood Hits	531	Target Neighborhood Hits	795	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALK_MOUSE
θ value	θ > 10 (rank : 552)	NC score	0.061921 (rank : 625)
Query Neighborhood Hits	531	Target Neighborhood Hits	811	Shared Neighborhood Hits	49
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ALMS1_HUMAN
θ value	θ > 10 (rank : 553)	NC score	0.057317 (rank : 719)
Query Neighborhood Hits	531	Target Neighborhood Hits	356	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

AMPH_HUMAN
θ value	θ > 10 (rank : 554)	NC score	0.066481 (rank : 588)
Query Neighborhood Hits	531	Target Neighborhood Hits	455	Shared Neighborhood Hits	95
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ANM2_HUMAN
θ value	θ > 10 (rank : 555)	NC score	0.062405 (rank : 617)
Query Neighborhood Hits	531	Target Neighborhood Hits	175	Shared Neighborhood Hits	44
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANM2_MOUSE
θ value	θ > 10 (rank : 556)	NC score	0.056836 (rank : 743)
Query Neighborhood Hits	531	Target Neighborhood Hits	175	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ANPRA_HUMAN
θ value	θ > 10 (rank : 557)	NC score	0.050518 (rank : 880)
Query Neighborhood Hits	531	Target Neighborhood Hits	612	Shared Neighborhood Hits	43
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

ANR11_HUMAN
θ value	θ > 10 (rank : 558)	NC score	0.059744 (rank : 650)
Query Neighborhood Hits	531	Target Neighborhood Hits	1289	Shared Neighborhood Hits	147
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

APC_HUMAN
θ value	θ > 10 (rank : 559)	NC score	0.052619 (rank : 837)
Query Neighborhood Hits	531	Target Neighborhood Hits	603	Shared Neighborhood Hits	86
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

APS_HUMAN
θ value	θ > 10 (rank : 560)	NC score	0.141913 (rank : 177)
Query Neighborhood Hits	531	Target Neighborhood Hits	162	Shared Neighborhood Hits	64
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 561)	NC score	0.118567 (rank : 248)
Query Neighborhood Hits	531	Target Neighborhood Hits	134	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APXL_HUMAN
θ value	θ > 10 (rank : 562)	NC score	0.055707 (rank : 771)
Query Neighborhood Hits	531	Target Neighborhood Hits	553	Shared Neighborhood Hits	79
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

ARAF_HUMAN
θ value	θ > 10 (rank : 563)	NC score	0.051763 (rank : 856)
Query Neighborhood Hits	531	Target Neighborhood Hits	924	Shared Neighborhood Hits	57
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

ARAF_MOUSE
θ value	θ > 10 (rank : 564)	NC score	0.050674 (rank : 877)
Query Neighborhood Hits	531	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

ARHG6_HUMAN
θ value	θ > 10 (rank : 565)	NC score	0.066508 (rank : 587)
Query Neighborhood Hits	531	Target Neighborhood Hits	376	Shared Neighborhood Hits	50
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 566)	NC score	0.064946 (rank : 603)
Query Neighborhood Hits	531	Target Neighborhood Hits	394	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 567)	NC score	0.077206 (rank : 487)
Query Neighborhood Hits	531	Target Neighborhood Hits	347	Shared Neighborhood Hits	54
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 568)	NC score	0.078462 (rank : 477)
Query Neighborhood Hits	531	Target Neighborhood Hits	396	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARMX2_MOUSE
θ value	θ > 10 (rank : 569)	NC score	0.056965 (rank : 739)
Query Neighborhood Hits	531	Target Neighborhood Hits	349	Shared Neighborhood Hits	93
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

ATX1_MOUSE
θ value	θ > 10 (rank : 570)	NC score	0.108206 (rank : 294)
Query Neighborhood Hits	531	Target Neighborhood Hits	264	Shared Neighborhood Hits	97
SwissProt Accessions	P54254	Gene names	Atxn1, Sca1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).

ATX2L_HUMAN
θ value	θ > 10 (rank : 571)	NC score	0.102432 (rank : 323)
Query Neighborhood Hits	531	Target Neighborhood Hits	443	Shared Neighborhood Hits	117
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

ATX2L_MOUSE
θ value	θ > 10 (rank : 572)	NC score	0.092157 (rank : 389)
Query Neighborhood Hits	531	Target Neighborhood Hits	401	Shared Neighborhood Hits	109
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

ATX2_MOUSE
θ value	θ > 10 (rank : 573)	NC score	0.106224 (rank : 306)
Query Neighborhood Hits	531	Target Neighborhood Hits	445	Shared Neighborhood Hits	125
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

ATX7_MOUSE
θ value	θ > 10 (rank : 574)	NC score	0.109461 (rank : 286)
Query Neighborhood Hits	531	Target Neighborhood Hits	328	Shared Neighborhood Hits	125
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

BAG3_HUMAN
θ value	θ > 10 (rank : 575)	NC score	0.093111 (rank : 382)
Query Neighborhood Hits	531	Target Neighborhood Hits	314	Shared Neighborhood Hits	92
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BAT3_HUMAN
θ value	θ > 10 (rank : 576)	NC score	0.086079 (rank : 420)
Query Neighborhood Hits	531	Target Neighborhood Hits	490	Shared Neighborhood Hits	113
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

BAT3_MOUSE
θ value	θ > 10 (rank : 577)	NC score	0.083008 (rank : 440)
Query Neighborhood Hits	531	Target Neighborhood Hits	518	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

BAZ2A_MOUSE
θ value	θ > 10 (rank : 578)	NC score	0.102923 (rank : 319)
Query Neighborhood Hits	531	Target Neighborhood Hits	744	Shared Neighborhood Hits	159
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

BCAR1_MOUSE
θ value	θ > 10 (rank : 579)	NC score	0.122598 (rank : 233)
Query Neighborhood Hits	531	Target Neighborhood Hits	438	Shared Neighborhood Hits	158
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR3_HUMAN
θ value	θ > 10 (rank : 580)	NC score	0.107373 (rank : 299)
Query Neighborhood Hits	531	Target Neighborhood Hits	129	Shared Neighborhood Hits	53
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 581)	NC score	0.107897 (rank : 295)
Query Neighborhood Hits	531	Target Neighborhood Hits	127	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCOR_HUMAN
θ value	θ > 10 (rank : 582)	NC score	0.054982 (rank : 785)
Query Neighborhood Hits	531	Target Neighborhood Hits	609	Shared Neighborhood Hits	91
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

BLK_HUMAN
θ value	θ > 10 (rank : 583)	NC score	0.101279 (rank : 332)
Query Neighborhood Hits	531	Target Neighborhood Hits	994	Shared Neighborhood Hits	95
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 584)	NC score	0.102827 (rank : 320)
Query Neighborhood Hits	531	Target Neighborhood Hits	992	Shared Neighborhood Hits	95
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BPTF_HUMAN
θ value	θ > 10 (rank : 585)	NC score	0.068746 (rank : 564)
Query Neighborhood Hits	531	Target Neighborhood Hits	786	Shared Neighborhood Hits	89
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

BRD8_MOUSE
θ value	θ > 10 (rank : 586)	NC score	0.054161 (rank : 807)
Query Neighborhood Hits	531	Target Neighborhood Hits	422	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

BSN_HUMAN
θ value	θ > 10 (rank : 587)	NC score	0.127065 (rank : 219)
Query Neighborhood Hits	531	Target Neighborhood Hits	1537	Shared Neighborhood Hits	230
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BSN_MOUSE
θ value	θ > 10 (rank : 588)	NC score	0.192835 (rank : 73)
Query Neighborhood Hits	531	Target Neighborhood Hits	2057	Shared Neighborhood Hits	324
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CABIN_HUMAN
θ value	θ > 10 (rank : 589)	NC score	0.092361 (rank : 386)
Query Neighborhood Hits	531	Target Neighborhood Hits	490	Shared Neighborhood Hits	122
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

CASC3_MOUSE
θ value	θ > 10 (rank : 590)	NC score	0.073734 (rank : 513)
Query Neighborhood Hits	531	Target Neighborhood Hits	333	Shared Neighborhood Hits	90
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

CASL_HUMAN
θ value	θ > 10 (rank : 591)	NC score	0.054458 (rank : 799)
Query Neighborhood Hits	531	Target Neighborhood Hits	259	Shared Neighborhood Hits	62
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 592)	NC score	0.052381 (rank : 843)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CBL_MOUSE
θ value	θ > 10 (rank : 593)	NC score	0.057407 (rank : 717)
Query Neighborhood Hits	531	Target Neighborhood Hits	426	Shared Neighborhood Hits	92
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

CD248_HUMAN
θ value	θ > 10 (rank : 594)	NC score	0.097918 (rank : 355)
Query Neighborhood Hits	531	Target Neighborhood Hits	679	Shared Neighborhood Hits	156
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD248_MOUSE
θ value	θ > 10 (rank : 595)	NC score	0.078698 (rank : 473)
Query Neighborhood Hits	531	Target Neighborhood Hits	578	Shared Neighborhood Hits	128
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CD2AP_HUMAN
θ value	θ > 10 (rank : 596)	NC score	0.084559 (rank : 429)
Query Neighborhood Hits	531	Target Neighborhood Hits	315	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 597)	NC score	0.089218 (rank : 407)
Query Neighborhood Hits	531	Target Neighborhood Hits	336	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CG1_HUMAN
θ value	θ > 10 (rank : 598)	NC score	0.074347 (rank : 508)
Query Neighborhood Hits	531	Target Neighborhood Hits	222	Shared Neighborhood Hits	68
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

CHIN_HUMAN
θ value	θ > 10 (rank : 599)	NC score	0.055531 (rank : 777)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_MOUSE
θ value	θ > 10 (rank : 600)	NC score	0.059377 (rank : 659)
Query Neighborhood Hits	531	Target Neighborhood Hits	229	Shared Neighborhood Hits	60
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CI079_HUMAN
θ value	θ > 10 (rank : 601)	NC score	0.058056 (rank : 694)
Query Neighborhood Hits	531	Target Neighborhood Hits	288	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

CIC_HUMAN
θ value	θ > 10 (rank : 602)	NC score	0.147467 (rank : 154)
Query Neighborhood Hits	531	Target Neighborhood Hits	992	Shared Neighborhood Hits	216
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

CIZ1_HUMAN
θ value	θ > 10 (rank : 603)	NC score	0.084239 (rank : 431)
Query Neighborhood Hits	531	Target Neighborhood Hits	359	Shared Neighborhood Hits	82
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

CJ012_HUMAN
θ value	θ > 10 (rank : 604)	NC score	0.078658 (rank : 475)
Query Neighborhood Hits	531	Target Neighborhood Hits	467	Shared Neighborhood Hits	89
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

CJ108_HUMAN
θ value	θ > 10 (rank : 605)	NC score	0.087954 (rank : 413)
Query Neighborhood Hits	531	Target Neighborhood Hits	165	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

CK024_HUMAN
θ value	θ > 10 (rank : 606)	NC score	0.126772 (rank : 220)
Query Neighborhood Hits	531	Target Neighborhood Hits	408	Shared Neighborhood Hits	126
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CK024_MOUSE
θ value	θ > 10 (rank : 607)	NC score	0.087330 (rank : 416)
Query Neighborhood Hits	531	Target Neighborhood Hits	307	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

CN032_MOUSE
θ value	θ > 10 (rank : 608)	NC score	0.139000 (rank : 181)
Query Neighborhood Hits	531	Target Neighborhood Hits	233	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

CNOT3_HUMAN
θ value	θ > 10 (rank : 609)	NC score	0.066060 (rank : 596)
Query Neighborhood Hits	531	Target Neighborhood Hits	425	Shared Neighborhood Hits	64
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CNOT3_MOUSE
θ value	θ > 10 (rank : 610)	NC score	0.061957 (rank : 624)
Query Neighborhood Hits	531	Target Neighborhood Hits	504	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

CNOT4_MOUSE
θ value	θ > 10 (rank : 611)	NC score	0.058627 (rank : 676)
Query Neighborhood Hits	531	Target Neighborhood Hits	277	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

CO002_HUMAN
θ value	θ > 10 (rank : 612)	NC score	0.095893 (rank : 368)
Query Neighborhood Hits	531	Target Neighborhood Hits	387	Shared Neighborhood Hits	99
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

CO039_HUMAN
θ value	θ > 10 (rank : 613)	NC score	0.080284 (rank : 463)
Query Neighborhood Hits	531	Target Neighborhood Hits	264	Shared Neighborhood Hits	84
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

CO5A2_HUMAN
θ value	θ > 10 (rank : 614)	NC score	0.056542 (rank : 752)
Query Neighborhood Hits	531	Target Neighborhood Hits	760	Shared Neighborhood Hits	124
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

CRSP2_HUMAN
θ value	θ > 10 (rank : 615)	NC score	0.104598 (rank : 312)
Query Neighborhood Hits	531	Target Neighborhood Hits	380	Shared Neighborhood Hits	118
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

CRTC1_HUMAN
θ value	θ > 10 (rank : 616)	NC score	0.105464 (rank : 309)
Query Neighborhood Hits	531	Target Neighborhood Hits	319	Shared Neighborhood Hits	115
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

CRTC1_MOUSE
θ value	θ > 10 (rank : 617)	NC score	0.066270 (rank : 592)
Query Neighborhood Hits	531	Target Neighborhood Hits	230	Shared Neighborhood Hits	65
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

CS007_MOUSE
θ value	θ > 10 (rank : 618)	NC score	0.094647 (rank : 376)
Query Neighborhood Hits	531	Target Neighborhood Hits	464	Shared Neighborhood Hits	110
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

CS016_HUMAN
θ value	θ > 10 (rank : 619)	NC score	0.104115 (rank : 313)
Query Neighborhood Hits	531	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

CSF1R_HUMAN
θ value	θ > 10 (rank : 620)	NC score	0.057160 (rank : 727)
Query Neighborhood Hits	531	Target Neighborhood Hits	943	Shared Neighborhood Hits	46
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1R_MOUSE
θ value	θ > 10 (rank : 621)	NC score	0.055560 (rank : 774)
Query Neighborhood Hits	531	Target Neighborhood Hits	983	Shared Neighborhood Hits	47
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

CSF1_HUMAN
θ value	θ > 10 (rank : 622)	NC score	0.115195 (rank : 259)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	81
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

CSKI2_MOUSE
θ value	θ > 10 (rank : 623)	NC score	0.070703 (rank : 538)
Query Neighborhood Hits	531	Target Neighborhood Hits	812	Shared Neighborhood Hits	123
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSK_HUMAN
θ value	θ > 10 (rank : 624)	NC score	0.100108 (rank : 340)
Query Neighborhood Hits	531	Target Neighborhood Hits	1009	Shared Neighborhood Hits	94
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 625)	NC score	0.100064 (rank : 341)
Query Neighborhood Hits	531	Target Neighborhood Hits	1009	Shared Neighborhood Hits	94
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	θ > 10 (rank : 626)	NC score	0.057298 (rank : 721)
Query Neighborhood Hits	531	Target Neighborhood Hits	235	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

CT174_HUMAN
θ value	θ > 10 (rank : 627)	NC score	0.051297 (rank : 864)
Query Neighborhood Hits	531	Target Neighborhood Hits	181	Shared Neighborhood Hits	56
SwissProt Accessions	Q5JPB2, Q5TDR4, Q8TCP0	Gene names	C20orf174
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf174.

CTDP1_HUMAN
θ value	θ > 10 (rank : 628)	NC score	0.090655 (rank : 399)
Query Neighborhood Hits	531	Target Neighborhood Hits	416	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

DAB2_HUMAN
θ value	θ > 10 (rank : 629)	NC score	0.050898 (rank : 874)
Query Neighborhood Hits	531	Target Neighborhood Hits	197	Shared Neighborhood Hits	58
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

DACT1_HUMAN
θ value	θ > 10 (rank : 630)	NC score	0.067961 (rank : 571)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

DBNL_HUMAN
θ value	θ > 10 (rank : 631)	NC score	0.058332 (rank : 687)
Query Neighborhood Hits	531	Target Neighborhood Hits	244	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 632)	NC score	0.060029 (rank : 647)
Query Neighborhood Hits	531	Target Neighborhood Hits	306	Shared Neighborhood Hits	57
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DCC_MOUSE
θ value	θ > 10 (rank : 633)	NC score	0.060725 (rank : 638)
Query Neighborhood Hits	531	Target Neighborhood Hits	896	Shared Neighborhood Hits	162
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

DCP1A_HUMAN
θ value	θ > 10 (rank : 634)	NC score	0.076936 (rank : 489)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

DDR1_HUMAN
θ value	θ > 10 (rank : 635)	NC score	0.059435 (rank : 657)
Query Neighborhood Hits	531	Target Neighborhood Hits	819	Shared Neighborhood Hits	47
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

DDR1_MOUSE
θ value	θ > 10 (rank : 636)	NC score	0.059631 (rank : 653)
Query Neighborhood Hits	531	Target Neighborhood Hits	818	Shared Neighborhood Hits	47
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

DDR2_HUMAN
θ value	θ > 10 (rank : 637)	NC score	0.057085 (rank : 731)
Query Neighborhood Hits	531	Target Neighborhood Hits	818	Shared Neighborhood Hits	45
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DDR2_MOUSE
θ value	θ > 10 (rank : 638)	NC score	0.056895 (rank : 742)
Query Neighborhood Hits	531	Target Neighborhood Hits	813	Shared Neighborhood Hits	45
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

DGKK_HUMAN
θ value	θ > 10 (rank : 639)	NC score	0.055787 (rank : 769)
Query Neighborhood Hits	531	Target Neighborhood Hits	378	Shared Neighborhood Hits	73
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

DIAP1_MOUSE
θ value	θ > 10 (rank : 640)	NC score	0.068843 (rank : 562)
Query Neighborhood Hits	531	Target Neighborhood Hits	839	Shared Neighborhood Hits	90
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

DIAP2_HUMAN
θ value	θ > 10 (rank : 641)	NC score	0.052424 (rank : 841)
Query Neighborhood Hits	531	Target Neighborhood Hits	342	Shared Neighborhood Hits	49
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

DIAP2_MOUSE
θ value	θ > 10 (rank : 642)	NC score	0.056235 (rank : 757)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	55
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

DIDO1_HUMAN
θ value	θ > 10 (rank : 643)	NC score	0.159732 (rank : 131)
Query Neighborhood Hits	531	Target Neighborhood Hits	960	Shared Neighborhood Hits	201
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DMRTD_HUMAN
θ value	θ > 10 (rank : 644)	NC score	0.083525 (rank : 438)
Query Neighborhood Hits	531	Target Neighborhood Hits	216	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

DNMBP_HUMAN
θ value	θ > 10 (rank : 645)	NC score	0.069385 (rank : 554)
Query Neighborhood Hits	531	Target Neighborhood Hits	413	Shared Neighborhood Hits	70
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 646)	NC score	0.072859 (rank : 524)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	90
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DOK2_MOUSE
θ value	θ > 10 (rank : 647)	NC score	0.067533 (rank : 577)
Query Neighborhood Hits	531	Target Neighborhood Hits	244	Shared Neighborhood Hits	94
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

ECM1_MOUSE
θ value	θ > 10 (rank : 648)	NC score	0.067949 (rank : 573)
Query Neighborhood Hits	531	Target Neighborhood Hits	105	Shared Neighborhood Hits	47
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

EFS_HUMAN
θ value	θ > 10 (rank : 649)	NC score	0.080199 (rank : 464)
Query Neighborhood Hits	531	Target Neighborhood Hits	348	Shared Neighborhood Hits	96
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 650)	NC score	0.111780 (rank : 274)
Query Neighborhood Hits	531	Target Neighborhood Hits	389	Shared Neighborhood Hits	128
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EGFR_HUMAN
θ value	θ > 10 (rank : 651)	NC score	0.056032 (rank : 761)
Query Neighborhood Hits	531	Target Neighborhood Hits	939	Shared Neighborhood Hits	50
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

EGFR_MOUSE
θ value	θ > 10 (rank : 652)	NC score	0.055859 (rank : 764)
Query Neighborhood Hits	531	Target Neighborhood Hits	927	Shared Neighborhood Hits	49
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EHMT2_MOUSE
θ value	θ > 10 (rank : 653)	NC score	0.050567 (rank : 879)
Query Neighborhood Hits	531	Target Neighborhood Hits	750	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

EMSY_HUMAN
θ value	θ > 10 (rank : 654)	NC score	0.052224 (rank : 846)
Query Neighborhood Hits	531	Target Neighborhood Hits	296	Shared Neighborhood Hits	58
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

ENAM_HUMAN
θ value	θ > 10 (rank : 655)	NC score	0.074860 (rank : 502)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

ENAM_MOUSE
θ value	θ > 10 (rank : 656)	NC score	0.082444 (rank : 444)
Query Neighborhood Hits	531	Target Neighborhood Hits	229	Shared Neighborhood Hits	85
SwissProt Accessions	O55196	Gene names	Enam
Domain Architecture	No domain graphic available
Description	Enamelin precursor.

EPHA1_HUMAN
θ value	θ > 10 (rank : 657)	NC score	0.059480 (rank : 656)
Query Neighborhood Hits	531	Target Neighborhood Hits	997	Shared Neighborhood Hits	53
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

EPHA1_MOUSE
θ value	θ > 10 (rank : 658)	NC score	0.059693 (rank : 652)
Query Neighborhood Hits	531	Target Neighborhood Hits	958	Shared Neighborhood Hits	56
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA2_HUMAN
θ value	θ > 10 (rank : 659)	NC score	0.058412 (rank : 684)
Query Neighborhood Hits	531	Target Neighborhood Hits	1021	Shared Neighborhood Hits	53
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA2_MOUSE
θ value	θ > 10 (rank : 660)	NC score	0.058613 (rank : 677)
Query Neighborhood Hits	531	Target Neighborhood Hits	1020	Shared Neighborhood Hits	54
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHA3_HUMAN
θ value	θ > 10 (rank : 661)	NC score	0.054458 (rank : 800)
Query Neighborhood Hits	531	Target Neighborhood Hits	1005	Shared Neighborhood Hits	51
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 662)	NC score	0.054326 (rank : 804)
Query Neighborhood Hits	531	Target Neighborhood Hits	1009	Shared Neighborhood Hits	51
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

EPHA4_HUMAN
θ value	θ > 10 (rank : 663)	NC score	0.056550 (rank : 751)
Query Neighborhood Hits	531	Target Neighborhood Hits	975	Shared Neighborhood Hits	51
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

EPHA4_MOUSE
θ value	θ > 10 (rank : 664)	NC score	0.056613 (rank : 748)
Query Neighborhood Hits	531	Target Neighborhood Hits	982	Shared Neighborhood Hits	52
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA5_HUMAN
θ value	θ > 10 (rank : 665)	NC score	0.057593 (rank : 711)
Query Neighborhood Hits	531	Target Neighborhood Hits	1009	Shared Neighborhood Hits	55
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

EPHA5_MOUSE
θ value	θ > 10 (rank : 666)	NC score	0.059249 (rank : 663)
Query Neighborhood Hits	531	Target Neighborhood Hits	950	Shared Neighborhood Hits	53
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHA6_HUMAN
θ value	θ > 10 (rank : 667)	NC score	0.059004 (rank : 669)
Query Neighborhood Hits	531	Target Neighborhood Hits	959	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA6_MOUSE
θ value	θ > 10 (rank : 668)	NC score	0.058654 (rank : 675)
Query Neighborhood Hits	531	Target Neighborhood Hits	946	Shared Neighborhood Hits	50
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

EPHA7_HUMAN
θ value	θ > 10 (rank : 669)	NC score	0.055929 (rank : 763)
Query Neighborhood Hits	531	Target Neighborhood Hits	1053	Shared Neighborhood Hits	53
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
θ value	θ > 10 (rank : 670)	NC score	0.055817 (rank : 765)
Query Neighborhood Hits	531	Target Neighborhood Hits	1025	Shared Neighborhood Hits	53
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHA8_HUMAN
θ value	θ > 10 (rank : 671)	NC score	0.056932 (rank : 740)
Query Neighborhood Hits	531	Target Neighborhood Hits	956	Shared Neighborhood Hits	54
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	θ > 10 (rank : 672)	NC score	0.057226 (rank : 724)
Query Neighborhood Hits	531	Target Neighborhood Hits	969	Shared Neighborhood Hits	56
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	θ > 10 (rank : 673)	NC score	0.060087 (rank : 644)
Query Neighborhood Hits	531	Target Neighborhood Hits	960	Shared Neighborhood Hits	54
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

EPHB1_HUMAN
θ value	θ > 10 (rank : 674)	NC score	0.056985 (rank : 736)
Query Neighborhood Hits	531	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHB2_HUMAN
θ value	θ > 10 (rank : 675)	NC score	0.057175 (rank : 726)
Query Neighborhood Hits	531	Target Neighborhood Hits	983	Shared Neighborhood Hits	53
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	θ > 10 (rank : 676)	NC score	0.056903 (rank : 741)
Query Neighborhood Hits	531	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHB3_HUMAN
θ value	θ > 10 (rank : 677)	NC score	0.058393 (rank : 686)
Query Neighborhood Hits	531	Target Neighborhood Hits	996	Shared Neighborhood Hits	57
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

EPHB3_MOUSE
θ value	θ > 10 (rank : 678)	NC score	0.057997 (rank : 699)
Query Neighborhood Hits	531	Target Neighborhood Hits	996	Shared Neighborhood Hits	55
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB4_HUMAN
θ value	θ > 10 (rank : 679)	NC score	0.057998 (rank : 698)
Query Neighborhood Hits	531	Target Neighborhood Hits	1056	Shared Neighborhood Hits	55
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB4_MOUSE
θ value	θ > 10 (rank : 680)	NC score	0.057725 (rank : 705)
Query Neighborhood Hits	531	Target Neighborhood Hits	1013	Shared Neighborhood Hits	56
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

EPHB6_HUMAN
θ value	θ > 10 (rank : 681)	NC score	0.062104 (rank : 621)
Query Neighborhood Hits	531	Target Neighborhood Hits	912	Shared Neighborhood Hits	65
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

EPHB6_MOUSE
θ value	θ > 10 (rank : 682)	NC score	0.059821 (rank : 649)
Query Neighborhood Hits	531	Target Neighborhood Hits	906	Shared Neighborhood Hits	57
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

EPN3_HUMAN
θ value	θ > 10 (rank : 683)	NC score	0.051748 (rank : 857)
Query Neighborhood Hits	531	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H201, Q9BVN6, Q9NWK2	Gene names	EPN3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

EPN3_MOUSE
θ value	θ > 10 (rank : 684)	NC score	0.081023 (rank : 460)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	102
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

ERBB2_HUMAN
θ value	θ > 10 (rank : 685)	NC score	0.067016 (rank : 581)
Query Neighborhood Hits	531	Target Neighborhood Hits	1073	Shared Neighborhood Hits	109
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

ERBB2_MOUSE
θ value	θ > 10 (rank : 686)	NC score	0.059583 (rank : 655)
Query Neighborhood Hits	531	Target Neighborhood Hits	918	Shared Neighborhood Hits	58
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

ERBB3_HUMAN
θ value	θ > 10 (rank : 687)	NC score	0.057316 (rank : 720)
Query Neighborhood Hits	531	Target Neighborhood Hits	918	Shared Neighborhood Hits	44
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

ERBB3_MOUSE
θ value	θ > 10 (rank : 688)	NC score	0.056985 (rank : 735)
Query Neighborhood Hits	531	Target Neighborhood Hits	898	Shared Neighborhood Hits	45
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

ERBB4_HUMAN
θ value	θ > 10 (rank : 689)	NC score	0.058055 (rank : 695)
Query Neighborhood Hits	531	Target Neighborhood Hits	910	Shared Neighborhood Hits	49
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

ES8L1_HUMAN
θ value	θ > 10 (rank : 690)	NC score	0.060141 (rank : 643)
Query Neighborhood Hits	531	Target Neighborhood Hits	162	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 691)	NC score	0.051721 (rank : 858)
Query Neighborhood Hits	531	Target Neighborhood Hits	143	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 692)	NC score	0.057148 (rank : 728)
Query Neighborhood Hits	531	Target Neighborhood Hits	193	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 693)	NC score	0.054855 (rank : 789)
Query Neighborhood Hits	531	Target Neighborhood Hits	169	Shared Neighborhood Hits	43
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_HUMAN
θ value	θ > 10 (rank : 694)	NC score	0.075671 (rank : 495)
Query Neighborhood Hits	531	Target Neighborhood Hits	206	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_MOUSE
θ value	θ > 10 (rank : 695)	NC score	0.063950 (rank : 609)
Query Neighborhood Hits	531	Target Neighborhood Hits	168	Shared Neighborhood Hits	42
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

EVL_HUMAN
θ value	θ > 10 (rank : 696)	NC score	0.066270 (rank : 591)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

EVL_MOUSE
θ value	θ > 10 (rank : 697)	NC score	0.056195 (rank : 759)
Query Neighborhood Hits	531	Target Neighborhood Hits	203	Shared Neighborhood Hits	56
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

FAK1_HUMAN
θ value	θ > 10 (rank : 698)	NC score	0.057708 (rank : 707)
Query Neighborhood Hits	531	Target Neighborhood Hits	850	Shared Neighborhood Hits	48
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

FAK1_MOUSE
θ value	θ > 10 (rank : 699)	NC score	0.057463 (rank : 716)
Query Neighborhood Hits	531	Target Neighborhood Hits	850	Shared Neighborhood Hits	47
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

FAK2_HUMAN
θ value	θ > 10 (rank : 700)	NC score	0.059281 (rank : 662)
Query Neighborhood Hits	531	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FAK2_MOUSE
θ value	θ > 10 (rank : 701)	NC score	0.059034 (rank : 667)
Query Neighborhood Hits	531	Target Neighborhood Hits	851	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

FES_HUMAN
θ value	θ > 10 (rank : 702)	NC score	0.074781 (rank : 504)
Query Neighborhood Hits	531	Target Neighborhood Hits	978	Shared Neighborhood Hits	77
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FES_MOUSE
θ value	θ > 10 (rank : 703)	NC score	0.070444 (rank : 543)
Query Neighborhood Hits	531	Target Neighborhood Hits	980	Shared Neighborhood Hits	76
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

FGFR1_HUMAN
θ value	θ > 10 (rank : 704)	NC score	0.053063 (rank : 824)
Query Neighborhood Hits	531	Target Neighborhood Hits	1069	Shared Neighborhood Hits	50
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	θ > 10 (rank : 705)	NC score	0.053200 (rank : 821)
Query Neighborhood Hits	531	Target Neighborhood Hits	1068	Shared Neighborhood Hits	50
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR2_HUMAN
θ value	θ > 10 (rank : 706)	NC score	0.052628 (rank : 836)
Query Neighborhood Hits	531	Target Neighborhood Hits	1062	Shared Neighborhood Hits	48
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

FGFR2_MOUSE
θ value	θ > 10 (rank : 707)	NC score	0.052782 (rank : 831)
Query Neighborhood Hits	531	Target Neighborhood Hits	1062	Shared Neighborhood Hits	48
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

FGFR3_HUMAN
θ value	θ > 10 (rank : 708)	NC score	0.052881 (rank : 828)
Query Neighborhood Hits	531	Target Neighborhood Hits	1042	Shared Neighborhood Hits	48
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

FGFR3_MOUSE
θ value	θ > 10 (rank : 709)	NC score	0.052659 (rank : 834)
Query Neighborhood Hits	531	Target Neighborhood Hits	1059	Shared Neighborhood Hits	48
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

FGFR4_HUMAN
θ value	θ > 10 (rank : 710)	NC score	0.054831 (rank : 790)
Query Neighborhood Hits	531	Target Neighborhood Hits	1037	Shared Neighborhood Hits	51
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

FGFR4_MOUSE
θ value	θ > 10 (rank : 711)	NC score	0.055997 (rank : 762)
Query Neighborhood Hits	531	Target Neighborhood Hits	1026	Shared Neighborhood Hits	49
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

FHOD1_MOUSE
θ value	θ > 10 (rank : 712)	NC score	0.059314 (rank : 661)
Query Neighborhood Hits	531	Target Neighborhood Hits	217	Shared Neighborhood Hits	57
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

FLT3_HUMAN
θ value	θ > 10 (rank : 713)	NC score	0.057472 (rank : 713)
Query Neighborhood Hits	531	Target Neighborhood Hits	843	Shared Neighborhood Hits	45
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

FLT3_MOUSE
θ value	θ > 10 (rank : 714)	NC score	0.058117 (rank : 691)
Query Neighborhood Hits	531	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

FMN2_MOUSE
θ value	θ > 10 (rank : 715)	NC score	0.112867 (rank : 270)
Query Neighborhood Hits	531	Target Neighborhood Hits	349	Shared Neighborhood Hits	103
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

FMNL_MOUSE
θ value	θ > 10 (rank : 716)	NC score	0.082598 (rank : 442)
Query Neighborhood Hits	531	Target Neighborhood Hits	428	Shared Neighborhood Hits	73
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

FRK_HUMAN
θ value	θ > 10 (rank : 717)	NC score	0.106531 (rank : 303)
Query Neighborhood Hits	531	Target Neighborhood Hits	1058	Shared Neighborhood Hits	102
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FXL19_MOUSE
θ value	θ > 10 (rank : 718)	NC score	0.057211 (rank : 725)
Query Neighborhood Hits	531	Target Neighborhood Hits	217	Shared Neighborhood Hits	71
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

GA2L2_MOUSE
θ value	θ > 10 (rank : 719)	NC score	0.128554 (rank : 212)
Query Neighborhood Hits	531	Target Neighborhood Hits	395	Shared Neighborhood Hits	150
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

GAB2_MOUSE
θ value	θ > 10 (rank : 720)	NC score	0.060067 (rank : 646)
Query Neighborhood Hits	531	Target Neighborhood Hits	220	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GAK10_HUMAN
θ value	θ > 10 (rank : 721)	NC score	0.078655 (rank : 476)
Query Neighborhood Hits	531	Target Neighborhood Hits	289	Shared Neighborhood Hits	120
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GON4L_HUMAN
θ value	θ > 10 (rank : 722)	NC score	0.054716 (rank : 793)
Query Neighborhood Hits	531	Target Neighborhood Hits	555	Shared Neighborhood Hits	94
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

GON4L_MOUSE
θ value	θ > 10 (rank : 723)	NC score	0.069284 (rank : 555)
Query Neighborhood Hits	531	Target Neighborhood Hits	455	Shared Neighborhood Hits	97
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

GPS2_HUMAN
θ value	θ > 10 (rank : 724)	NC score	0.079957 (rank : 466)
Query Neighborhood Hits	531	Target Neighborhood Hits	459	Shared Neighborhood Hits	76
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

GPTC8_HUMAN
θ value	θ > 10 (rank : 725)	NC score	0.051126 (rank : 869)
Query Neighborhood Hits	531	Target Neighborhood Hits	366	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

GRAP2_HUMAN
θ value	θ > 10 (rank : 726)	NC score	0.183999 (rank : 81)
Query Neighborhood Hits	531	Target Neighborhood Hits	304	Shared Neighborhood Hits	81
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 727)	NC score	0.179707 (rank : 90)
Query Neighborhood Hits	531	Target Neighborhood Hits	297	Shared Neighborhood Hits	80
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRB10_HUMAN
θ value	θ > 10 (rank : 728)	NC score	0.137168 (rank : 189)
Query Neighborhood Hits	531	Target Neighborhood Hits	147	Shared Neighborhood Hits	66
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 729)	NC score	0.137251 (rank : 188)
Query Neighborhood Hits	531	Target Neighborhood Hits	156	Shared Neighborhood Hits	65
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 730)	NC score	0.143314 (rank : 172)
Query Neighborhood Hits	531	Target Neighborhood Hits	156	Shared Neighborhood Hits	70
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 731)	NC score	0.146207 (rank : 159)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	73
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

GRIN1_HUMAN
θ value	θ > 10 (rank : 732)	NC score	0.099278 (rank : 349)
Query Neighborhood Hits	531	Target Neighborhood Hits	681	Shared Neighborhood Hits	137
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

GRIN1_MOUSE
θ value	θ > 10 (rank : 733)	NC score	0.073715 (rank : 514)
Query Neighborhood Hits	531	Target Neighborhood Hits	337	Shared Neighborhood Hits	84
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

GTSE1_HUMAN
θ value	θ > 10 (rank : 734)	NC score	0.067956 (rank : 572)
Query Neighborhood Hits	531	Target Neighborhood Hits	193	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NYZ3, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9UGZ9, Q9Y557	Gene names	GTSE1
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (B99 homolog).

GTSE1_MOUSE
θ value	θ > 10 (rank : 735)	NC score	0.061514 (rank : 630)
Query Neighborhood Hits	531	Target Neighborhood Hits	245	Shared Neighborhood Hits	75
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

GUC2F_HUMAN
θ value	θ > 10 (rank : 736)	NC score	0.052243 (rank : 845)
Query Neighborhood Hits	531	Target Neighborhood Hits	740	Shared Neighborhood Hits	43
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

HCLS1_HUMAN
θ value	θ > 10 (rank : 737)	NC score	0.119163 (rank : 244)
Query Neighborhood Hits	531	Target Neighborhood Hits	358	Shared Neighborhood Hits	122
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 738)	NC score	0.091479 (rank : 393)
Query Neighborhood Hits	531	Target Neighborhood Hits	329	Shared Neighborhood Hits	98
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HGS_MOUSE
θ value	θ > 10 (rank : 739)	NC score	0.056763 (rank : 745)
Query Neighborhood Hits	531	Target Neighborhood Hits	589	Shared Neighborhood Hits	105
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HSF1_MOUSE
θ value	θ > 10 (rank : 740)	NC score	0.058174 (rank : 689)
Query Neighborhood Hits	531	Target Neighborhood Hits	267	Shared Neighborhood Hits	76
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

HSH2D_HUMAN
θ value	θ > 10 (rank : 741)	NC score	0.118999 (rank : 246)
Query Neighborhood Hits	531	Target Neighborhood Hits	159	Shared Neighborhood Hits	69
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 742)	NC score	0.093047 (rank : 383)
Query Neighborhood Hits	531	Target Neighborhood Hits	124	Shared Neighborhood Hits	50
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IASPP_MOUSE
θ value	θ > 10 (rank : 743)	NC score	0.174176 (rank : 101)
Query Neighborhood Hits	531	Target Neighborhood Hits	1024	Shared Neighborhood Hits	230
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IF4B_HUMAN
θ value	θ > 10 (rank : 744)	NC score	0.078847 (rank : 471)
Query Neighborhood Hits	531	Target Neighborhood Hits	417	Shared Neighborhood Hits	90
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

IF4B_MOUSE
θ value	θ > 10 (rank : 745)	NC score	0.077859 (rank : 483)
Query Neighborhood Hits	531	Target Neighborhood Hits	368	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

IF4G1_MOUSE
θ value	θ > 10 (rank : 746)	NC score	0.081930 (rank : 450)
Query Neighborhood Hits	531	Target Neighborhood Hits	534	Shared Neighborhood Hits	140
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

IGF1R_HUMAN
θ value	θ > 10 (rank : 747)	NC score	0.058002 (rank : 697)
Query Neighborhood Hits	531	Target Neighborhood Hits	977	Shared Neighborhood Hits	51
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IGF1R_MOUSE
θ value	θ > 10 (rank : 748)	NC score	0.058151 (rank : 690)
Query Neighborhood Hits	531	Target Neighborhood Hits	973	Shared Neighborhood Hits	49
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

IL3B2_MOUSE
θ value	θ > 10 (rank : 749)	NC score	0.078339 (rank : 478)
Query Neighborhood Hits	531	Target Neighborhood Hits	372	Shared Neighborhood Hits	117
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

IL3RB_MOUSE
θ value	θ > 10 (rank : 750)	NC score	0.074332 (rank : 510)
Query Neighborhood Hits	531	Target Neighborhood Hits	355	Shared Neighborhood Hits	114
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

ILK1_HUMAN
θ value	θ > 10 (rank : 751)	NC score	0.057275 (rank : 722)
Query Neighborhood Hits	531	Target Neighborhood Hits	857	Shared Neighborhood Hits	51
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 752)	NC score	0.057237 (rank : 723)
Query Neighborhood Hits	531	Target Neighborhood Hits	848	Shared Neighborhood Hits	51
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 753)	NC score	0.057807 (rank : 702)
Query Neighborhood Hits	531	Target Neighborhood Hits	858	Shared Neighborhood Hits	52
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

INP5E_HUMAN
θ value	θ > 10 (rank : 754)	NC score	0.054977 (rank : 786)
Query Neighborhood Hits	531	Target Neighborhood Hits	201	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

INSRR_HUMAN
θ value	θ > 10 (rank : 755)	NC score	0.058326 (rank : 688)
Query Neighborhood Hits	531	Target Neighborhood Hits	950	Shared Neighborhood Hits	53
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSRR_MOUSE
θ value	θ > 10 (rank : 756)	NC score	0.057901 (rank : 700)
Query Neighborhood Hits	531	Target Neighborhood Hits	961	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

INSR_HUMAN
θ value	θ > 10 (rank : 757)	NC score	0.056533 (rank : 753)
Query Neighborhood Hits	531	Target Neighborhood Hits	963	Shared Neighborhood Hits	48
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

INSR_MOUSE
θ value	θ > 10 (rank : 758)	NC score	0.056693 (rank : 746)
Query Neighborhood Hits	531	Target Neighborhood Hits	968	Shared Neighborhood Hits	51
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

IRAK3_MOUSE
θ value	θ > 10 (rank : 759)	NC score	0.050071 (rank : 890)
Query Neighborhood Hits	531	Target Neighborhood Hits	628	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

ITSN1_HUMAN
θ value	θ > 10 (rank : 760)	NC score	0.083815 (rank : 434)
Query Neighborhood Hits	531	Target Neighborhood Hits	1757	Shared Neighborhood Hits	169
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	θ > 10 (rank : 761)	NC score	0.081733 (rank : 452)
Query Neighborhood Hits	531	Target Neighborhood Hits	1669	Shared Neighborhood Hits	153
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

ITSN2_HUMAN
θ value	θ > 10 (rank : 762)	NC score	0.066457 (rank : 589)
Query Neighborhood Hits	531	Target Neighborhood Hits	1173	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	θ > 10 (rank : 763)	NC score	0.066154 (rank : 595)
Query Neighborhood Hits	531	Target Neighborhood Hits	1371	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JADE2_MOUSE
θ value	θ > 10 (rank : 764)	NC score	0.098774 (rank : 351)
Query Neighborhood Hits	531	Target Neighborhood Hits	560	Shared Neighborhood Hits	145
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

JAK1_HUMAN
θ value	θ > 10 (rank : 765)	NC score	0.053112 (rank : 823)
Query Neighborhood Hits	531	Target Neighborhood Hits	858	Shared Neighborhood Hits	48
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK1_MOUSE
θ value	θ > 10 (rank : 766)	NC score	0.053419 (rank : 819)
Query Neighborhood Hits	531	Target Neighborhood Hits	854	Shared Neighborhood Hits	48
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

JAK3_HUMAN
θ value	θ > 10 (rank : 767)	NC score	0.050803 (rank : 875)
Query Neighborhood Hits	531	Target Neighborhood Hits	827	Shared Neighborhood Hits	44
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

JIP1_HUMAN
θ value	θ > 10 (rank : 768)	NC score	0.064787 (rank : 604)
Query Neighborhood Hits	531	Target Neighborhood Hits	271	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	θ > 10 (rank : 769)	NC score	0.069576 (rank : 551)
Query Neighborhood Hits	531	Target Neighborhood Hits	259	Shared Neighborhood Hits	82
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

K0310_HUMAN
θ value	θ > 10 (rank : 770)	NC score	0.093203 (rank : 381)
Query Neighborhood Hits	531	Target Neighborhood Hits	420	Shared Neighborhood Hits	120
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

K1210_HUMAN
θ value	θ > 10 (rank : 771)	NC score	0.053696 (rank : 814)
Query Neighborhood Hits	531	Target Neighborhood Hits	219	Shared Neighborhood Hits	61
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

K1543_HUMAN
θ value	θ > 10 (rank : 772)	NC score	0.108704 (rank : 290)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	135
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1543_MOUSE
θ value	θ > 10 (rank : 773)	NC score	0.130254 (rank : 210)
Query Neighborhood Hits	531	Target Neighborhood Hits	497	Shared Neighborhood Hits	143
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

K1683_HUMAN
θ value	θ > 10 (rank : 774)	NC score	0.083925 (rank : 433)
Query Neighborhood Hits	531	Target Neighborhood Hits	240	Shared Neighborhood Hits	71
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

KI67_HUMAN
θ value	θ > 10 (rank : 775)	NC score	0.081500 (rank : 456)
Query Neighborhood Hits	531	Target Neighborhood Hits	581	Shared Neighborhood Hits	84
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

KIT_HUMAN
θ value	θ > 10 (rank : 776)	NC score	0.054769 (rank : 792)
Query Neighborhood Hits	531	Target Neighborhood Hits	953	Shared Neighborhood Hits	48
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KIT_MOUSE
θ value	θ > 10 (rank : 777)	NC score	0.054465 (rank : 798)
Query Neighborhood Hits	531	Target Neighborhood Hits	949	Shared Neighborhood Hits	45
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

KSR1_HUMAN
θ value	θ > 10 (rank : 778)	NC score	0.050128 (rank : 889)
Query Neighborhood Hits	531	Target Neighborhood Hits	867	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

KSR2_HUMAN
θ value	θ > 10 (rank : 779)	NC score	0.054669 (rank : 796)
Query Neighborhood Hits	531	Target Neighborhood Hits	920	Shared Neighborhood Hits	84
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

KSYK_HUMAN
θ value	θ > 10 (rank : 780)	NC score	0.086719 (rank : 418)
Query Neighborhood Hits	531	Target Neighborhood Hits	901	Shared Neighborhood Hits	86
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

KSYK_MOUSE
θ value	θ > 10 (rank : 781)	NC score	0.089257 (rank : 406)
Query Neighborhood Hits	531	Target Neighborhood Hits	944	Shared Neighborhood Hits	104
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

LAD1_MOUSE
θ value	θ > 10 (rank : 782)	NC score	0.138010 (rank : 184)
Query Neighborhood Hits	531	Target Neighborhood Hits	391	Shared Neighborhood Hits	96
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LARP4_MOUSE
θ value	θ > 10 (rank : 783)	NC score	0.073058 (rank : 521)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

LASP1_HUMAN
θ value	θ > 10 (rank : 784)	NC score	0.058690 (rank : 674)
Query Neighborhood Hits	531	Target Neighborhood Hits	293	Shared Neighborhood Hits	48
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	θ > 10 (rank : 785)	NC score	0.058397 (rank : 685)
Query Neighborhood Hits	531	Target Neighborhood Hits	297	Shared Neighborhood Hits	48
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LCK_HUMAN
θ value	θ > 10 (rank : 786)	NC score	0.103823 (rank : 316)
Query Neighborhood Hits	531	Target Neighborhood Hits	987	Shared Neighborhood Hits	92
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 787)	NC score	0.103296 (rank : 317)
Query Neighborhood Hits	531	Target Neighborhood Hits	981	Shared Neighborhood Hits	93
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LEUK_HUMAN
θ value	θ > 10 (rank : 788)	NC score	0.062627 (rank : 615)
Query Neighborhood Hits	531	Target Neighborhood Hits	213	Shared Neighborhood Hits	50
SwissProt Accessions	P16150	Gene names	SPN, CD43
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Galactoglycoprotein) (GALGP) (CD43 antigen).

LIPS_HUMAN
θ value	θ > 10 (rank : 789)	NC score	0.073490 (rank : 518)
Query Neighborhood Hits	531	Target Neighborhood Hits	314	Shared Neighborhood Hits	93
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

LNK_HUMAN
θ value	θ > 10 (rank : 790)	NC score	0.128195 (rank : 213)
Query Neighborhood Hits	531	Target Neighborhood Hits	151	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 791)	NC score	0.131111 (rank : 208)
Query Neighborhood Hits	531	Target Neighborhood Hits	132	Shared Neighborhood Hits	63
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LPP_HUMAN
θ value	θ > 10 (rank : 792)	NC score	0.162641 (rank : 125)
Query Neighborhood Hits	531	Target Neighborhood Hits	775	Shared Neighborhood Hits	207
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

LTK_HUMAN
θ value	θ > 10 (rank : 793)	NC score	0.062540 (rank : 616)
Query Neighborhood Hits	531	Target Neighborhood Hits	774	Shared Neighborhood Hits	44
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

LTK_MOUSE
θ value	θ > 10 (rank : 794)	NC score	0.062253 (rank : 620)
Query Neighborhood Hits	531	Target Neighborhood Hits	770	Shared Neighborhood Hits	46
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

M3K10_HUMAN
θ value	θ > 10 (rank : 795)	NC score	0.058069 (rank : 693)
Query Neighborhood Hits	531	Target Neighborhood Hits	1071	Shared Neighborhood Hits	82
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K9_HUMAN
θ value	θ > 10 (rank : 796)	NC score	0.060595 (rank : 641)
Query Neighborhood Hits	531	Target Neighborhood Hits	1123	Shared Neighborhood Hits	103
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

M3KL4_HUMAN
θ value	θ > 10 (rank : 797)	NC score	0.058573 (rank : 681)
Query Neighborhood Hits	531	Target Neighborhood Hits	1087	Shared Neighborhood Hits	75
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MADCA_HUMAN
θ value	θ > 10 (rank : 798)	NC score	0.054542 (rank : 797)
Query Neighborhood Hits	531	Target Neighborhood Hits	221	Shared Neighborhood Hits	50
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MAML1_MOUSE
θ value	θ > 10 (rank : 799)	NC score	0.054994 (rank : 784)
Query Neighborhood Hits	531	Target Neighborhood Hits	279	Shared Neighborhood Hits	67
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

MAML3_HUMAN
θ value	θ > 10 (rank : 800)	NC score	0.058919 (rank : 670)
Query Neighborhood Hits	531	Target Neighborhood Hits	323	Shared Neighborhood Hits	55
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

MAP1B_HUMAN
θ value	θ > 10 (rank : 801)	NC score	0.066659 (rank : 585)
Query Neighborhood Hits	531	Target Neighborhood Hits	903	Shared Neighborhood Hits	97
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

MAP4_MOUSE
θ value	θ > 10 (rank : 802)	NC score	0.084024 (rank : 432)
Query Neighborhood Hits	531	Target Neighborhood Hits	409	Shared Neighborhood Hits	87
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MATK_HUMAN
θ value	θ > 10 (rank : 803)	NC score	0.091821 (rank : 391)
Query Neighborhood Hits	531	Target Neighborhood Hits	954	Shared Neighborhood Hits	95
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 804)	NC score	0.090847 (rank : 396)
Query Neighborhood Hits	531	Target Neighborhood Hits	952	Shared Neighborhood Hits	94
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MAVS_HUMAN
θ value	θ > 10 (rank : 805)	NC score	0.072225 (rank : 531)
Query Neighborhood Hits	531	Target Neighborhood Hits	271	Shared Neighborhood Hits	78
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

MBB1A_HUMAN
θ value	θ > 10 (rank : 806)	NC score	0.117562 (rank : 252)
Query Neighborhood Hits	531	Target Neighborhood Hits	665	Shared Neighborhood Hits	151
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

MDC1_HUMAN
θ value	θ > 10 (rank : 807)	NC score	0.219751 (rank : 49)
Query Neighborhood Hits	531	Target Neighborhood Hits	1446	Shared Neighborhood Hits	239
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MDC1_MOUSE
θ value	θ > 10 (rank : 808)	NC score	0.243489 (rank : 31)
Query Neighborhood Hits	531	Target Neighborhood Hits	998	Shared Neighborhood Hits	233
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MEF2B_HUMAN
θ value	θ > 10 (rank : 809)	NC score	0.051064 (rank : 870)
Query Neighborhood Hits	531	Target Neighborhood Hits	150	Shared Neighborhood Hits	58
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

MEGF9_MOUSE
θ value	θ > 10 (rank : 810)	NC score	0.076927 (rank : 490)
Query Neighborhood Hits	531	Target Neighborhood Hits	896	Shared Neighborhood Hits	167
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

MERTK_HUMAN
θ value	θ > 10 (rank : 811)	NC score	0.058574 (rank : 680)
Query Neighborhood Hits	531	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MERTK_MOUSE
θ value	θ > 10 (rank : 812)	NC score	0.058075 (rank : 692)
Query Neighborhood Hits	531	Target Neighborhood Hits	974	Shared Neighborhood Hits	55
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

MET_HUMAN
θ value	θ > 10 (rank : 813)	NC score	0.054393 (rank : 802)
Query Neighborhood Hits	531	Target Neighborhood Hits	831	Shared Neighborhood Hits	43
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MET_MOUSE
θ value	θ > 10 (rank : 814)	NC score	0.054684 (rank : 794)
Query Neighborhood Hits	531	Target Neighborhood Hits	844	Shared Neighborhood Hits	44
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

MINT_MOUSE
θ value	θ > 10 (rank : 815)	NC score	0.133241 (rank : 201)
Query Neighborhood Hits	531	Target Neighborhood Hits	1514	Shared Neighborhood Hits	244
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

MLTK_HUMAN
θ value	θ > 10 (rank : 816)	NC score	0.051374 (rank : 861)
Query Neighborhood Hits	531	Target Neighborhood Hits	911	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

MLTK_MOUSE
θ value	θ > 10 (rank : 817)	NC score	0.050249 (rank : 886)
Query Neighborhood Hits	531	Target Neighborhood Hits	874	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

MTSS1_HUMAN
θ value	θ > 10 (rank : 818)	NC score	0.101240 (rank : 333)
Query Neighborhood Hits	531	Target Neighborhood Hits	504	Shared Neighborhood Hits	113
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

MTSS1_MOUSE
θ value	θ > 10 (rank : 819)	NC score	0.131805 (rank : 205)
Query Neighborhood Hits	531	Target Neighborhood Hits	592	Shared Neighborhood Hits	159
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

MUC1_HUMAN
θ value	θ > 10 (rank : 820)	NC score	0.251340 (rank : 26)
Query Neighborhood Hits	531	Target Neighborhood Hits	975	Shared Neighborhood Hits	230
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

MUC1_MOUSE
θ value	θ > 10 (rank : 821)	NC score	0.065030 (rank : 601)
Query Neighborhood Hits	531	Target Neighborhood Hits	388	Shared Neighborhood Hits	57
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

MUC5B_HUMAN
θ value	θ > 10 (rank : 822)	NC score	0.064053 (rank : 608)
Query Neighborhood Hits	531	Target Neighborhood Hits	1020	Shared Neighborhood Hits	108
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

MUC7_HUMAN
θ value	θ > 10 (rank : 823)	NC score	0.123699 (rank : 228)
Query Neighborhood Hits	531	Target Neighborhood Hits	538	Shared Neighborhood Hits	113
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

MUCDL_HUMAN
θ value	θ > 10 (rank : 824)	NC score	0.134735 (rank : 196)
Query Neighborhood Hits	531	Target Neighborhood Hits	777	Shared Neighborhood Hits	182
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

MUSK_HUMAN
θ value	θ > 10 (rank : 825)	NC score	0.055716 (rank : 770)
Query Neighborhood Hits	531	Target Neighborhood Hits	1074	Shared Neighborhood Hits	48
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

MUSK_MOUSE
θ value	θ > 10 (rank : 826)	NC score	0.055560 (rank : 773)
Query Neighborhood Hits	531	Target Neighborhood Hits	1057	Shared Neighborhood Hits	47
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

MYST3_MOUSE
θ value	θ > 10 (rank : 827)	NC score	0.060067 (rank : 645)
Query Neighborhood Hits	531	Target Neighborhood Hits	688	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

NACAM_MOUSE
θ value	θ > 10 (rank : 828)	NC score	0.258004 (rank : 23)
Query Neighborhood Hits	531	Target Neighborhood Hits	1866	Shared Neighborhood Hits	323
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NCF1_HUMAN
θ value	θ > 10 (rank : 829)	NC score	0.068684 (rank : 565)
Query Neighborhood Hits	531	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF1_MOUSE
θ value	θ > 10 (rank : 830)	NC score	0.072014 (rank : 532)
Query Neighborhood Hits	531	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF2_HUMAN
θ value	θ > 10 (rank : 831)	NC score	0.067490 (rank : 578)
Query Neighborhood Hits	531	Target Neighborhood Hits	229	Shared Neighborhood Hits	43
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCOR1_HUMAN
θ value	θ > 10 (rank : 832)	NC score	0.059175 (rank : 665)
Query Neighborhood Hits	531	Target Neighborhood Hits	577	Shared Neighborhood Hits	87
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

NEBL_HUMAN
θ value	θ > 10 (rank : 833)	NC score	0.053744 (rank : 813)
Query Neighborhood Hits	531	Target Neighborhood Hits	457	Shared Neighborhood Hits	62
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NELFA_HUMAN
θ value	θ > 10 (rank : 834)	NC score	0.057757 (rank : 703)
Query Neighborhood Hits	531	Target Neighborhood Hits	161	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H3P2, O95392	Gene names	WHSC2, NELFA
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein).

NFH_MOUSE
θ value	θ > 10 (rank : 835)	NC score	0.144940 (rank : 166)
Query Neighborhood Hits	531	Target Neighborhood Hits	2247	Shared Neighborhood Hits	286
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NFRKB_MOUSE
θ value	θ > 10 (rank : 836)	NC score	0.069087 (rank : 559)
Query Neighborhood Hits	531	Target Neighborhood Hits	393	Shared Neighborhood Hits	93
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

NIPBL_HUMAN
θ value	θ > 10 (rank : 837)	NC score	0.100581 (rank : 335)
Query Neighborhood Hits	531	Target Neighborhood Hits	1311	Shared Neighborhood Hits	163
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NPAS4_MOUSE
θ value	θ > 10 (rank : 838)	NC score	0.061694 (rank : 626)
Query Neighborhood Hits	531	Target Neighborhood Hits	245	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

NPBL_MOUSE
θ value	θ > 10 (rank : 839)	NC score	0.097069 (rank : 357)
Query Neighborhood Hits	531	Target Neighborhood Hits	1041	Shared Neighborhood Hits	143
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

NPHP1_HUMAN
θ value	θ > 10 (rank : 840)	NC score	0.088282 (rank : 409)
Query Neighborhood Hits	531	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 841)	NC score	0.096726 (rank : 360)
Query Neighborhood Hits	531	Target Neighborhood Hits	267	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

NRX2A_HUMAN
θ value	θ > 10 (rank : 842)	NC score	0.069523 (rank : 552)
Query Neighborhood Hits	531	Target Neighborhood Hits	614	Shared Neighborhood Hits	149
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

NRX2B_HUMAN
θ value	θ > 10 (rank : 843)	NC score	0.105115 (rank : 310)
Query Neighborhood Hits	531	Target Neighborhood Hits	481	Shared Neighborhood Hits	140
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

NTRK1_HUMAN
θ value	θ > 10 (rank : 844)	NC score	0.057670 (rank : 709)
Query Neighborhood Hits	531	Target Neighborhood Hits	1023	Shared Neighborhood Hits	51
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

NTRK2_HUMAN
θ value	θ > 10 (rank : 845)	NC score	0.055051 (rank : 783)
Query Neighborhood Hits	531	Target Neighborhood Hits	1081	Shared Neighborhood Hits	49
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

NTRK2_MOUSE
θ value	θ > 10 (rank : 846)	NC score	0.054927 (rank : 787)
Query Neighborhood Hits	531	Target Neighborhood Hits	1088	Shared Neighborhood Hits	49
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

NTRK3_HUMAN
θ value	θ > 10 (rank : 847)	NC score	0.057465 (rank : 715)
Query Neighborhood Hits	531	Target Neighborhood Hits	1115	Shared Neighborhood Hits	52
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

NU214_HUMAN
θ value	θ > 10 (rank : 848)	NC score	0.088151 (rank : 410)
Query Neighborhood Hits	531	Target Neighborhood Hits	657	Shared Neighborhood Hits	105
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

NUCKS_HUMAN
θ value	θ > 10 (rank : 849)	NC score	0.052645 (rank : 835)
Query Neighborhood Hits	531	Target Neighborhood Hits	143	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H1E3, Q9H1D6, Q9H723	Gene names	NUCKS1, NUCKS
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (P1).

NUMBL_HUMAN
θ value	θ > 10 (rank : 850)	NC score	0.113181 (rank : 268)
Query Neighborhood Hits	531	Target Neighborhood Hits	394	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

NUP53_HUMAN
θ value	θ > 10 (rank : 851)	NC score	0.063823 (rank : 611)
Query Neighborhood Hits	531	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

OBF1_HUMAN
θ value	θ > 10 (rank : 852)	NC score	0.094534 (rank : 377)
Query Neighborhood Hits	531	Target Neighborhood Hits	203	Shared Neighborhood Hits	84
SwissProt Accessions	Q16633, Q14983	Gene names	POU2AF1, OBF1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B).

OGFR_HUMAN
θ value	θ > 10 (rank : 853)	NC score	0.237655 (rank : 35)
Query Neighborhood Hits	531	Target Neighborhood Hits	1582	Shared Neighborhood Hits	296
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

OGFR_MOUSE
θ value	θ > 10 (rank : 854)	NC score	0.105873 (rank : 308)
Query Neighborhood Hits	531	Target Neighborhood Hits	584	Shared Neighborhood Hits	123
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

OSTF1_HUMAN
θ value	θ > 10 (rank : 855)	NC score	0.081468 (rank : 457)
Query Neighborhood Hits	531	Target Neighborhood Hits	466	Shared Neighborhood Hits	53
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 856)	NC score	0.078080 (rank : 480)
Query Neighborhood Hits	531	Target Neighborhood Hits	467	Shared Neighborhood Hits	52
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN1_HUMAN
θ value	θ > 10 (rank : 857)	NC score	0.065669 (rank : 598)
Query Neighborhood Hits	531	Target Neighborhood Hits	320	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 858)	NC score	0.064111 (rank : 607)
Query Neighborhood Hits	531	Target Neighborhood Hits	283	Shared Neighborhood Hits	48
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 859)	NC score	0.068293 (rank : 568)
Query Neighborhood Hits	531	Target Neighborhood Hits	339	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 860)	NC score	0.070425 (rank : 544)
Query Neighborhood Hits	531	Target Neighborhood Hits	382	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 861)	NC score	0.057037 (rank : 734)
Query Neighborhood Hits	531	Target Neighborhood Hits	385	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 862)	NC score	0.057054 (rank : 733)
Query Neighborhood Hits	531	Target Neighborhood Hits	380	Shared Neighborhood Hits	52
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PDC6I_MOUSE
θ value	θ > 10 (rank : 863)	NC score	0.066452 (rank : 590)
Query Neighborhood Hits	531	Target Neighborhood Hits	275	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

PDLI7_HUMAN
θ value	θ > 10 (rank : 864)	NC score	0.053783 (rank : 811)
Query Neighborhood Hits	531	Target Neighborhood Hits	547	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

PDZD2_HUMAN
θ value	θ > 10 (rank : 865)	NC score	0.072615 (rank : 528)
Query Neighborhood Hits	531	Target Neighborhood Hits	772	Shared Neighborhood Hits	133
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PELP1_HUMAN
θ value	θ > 10 (rank : 866)	NC score	0.075296 (rank : 499)
Query Neighborhood Hits	531	Target Neighborhood Hits	596	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

PELP1_MOUSE
θ value	θ > 10 (rank : 867)	NC score	0.122147 (rank : 236)
Query Neighborhood Hits	531	Target Neighborhood Hits	709	Shared Neighborhood Hits	147
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PER2_MOUSE
θ value	θ > 10 (rank : 868)	NC score	0.078975 (rank : 469)
Query Neighborhood Hits	531	Target Neighborhood Hits	325	Shared Neighborhood Hits	98
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

PER3_HUMAN
θ value	θ > 10 (rank : 869)	NC score	0.096447 (rank : 363)
Query Neighborhood Hits	531	Target Neighborhood Hits	479	Shared Neighborhood Hits	131
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PF21B_MOUSE
θ value	θ > 10 (rank : 870)	NC score	0.057142 (rank : 729)
Query Neighborhood Hits	531	Target Neighborhood Hits	278	Shared Neighborhood Hits	73
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

PGFRA_HUMAN
θ value	θ > 10 (rank : 871)	NC score	0.056592 (rank : 749)
Query Neighborhood Hits	531	Target Neighborhood Hits	980	Shared Neighborhood Hits	50
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
θ value	θ > 10 (rank : 872)	NC score	0.056584 (rank : 750)
Query Neighborhood Hits	531	Target Neighborhood Hits	975	Shared Neighborhood Hits	48
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRB_HUMAN
θ value	θ > 10 (rank : 873)	NC score	0.057074 (rank : 732)
Query Neighborhood Hits	531	Target Neighborhood Hits	962	Shared Neighborhood Hits	50
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PGFRB_MOUSE
θ value	θ > 10 (rank : 874)	NC score	0.056971 (rank : 737)
Query Neighborhood Hits	531	Target Neighborhood Hits	960	Shared Neighborhood Hits	49
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PHC2_HUMAN
θ value	θ > 10 (rank : 875)	NC score	0.091835 (rank : 390)
Query Neighborhood Hits	531	Target Neighborhood Hits	388	Shared Neighborhood Hits	126
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

PHLB1_HUMAN
θ value	θ > 10 (rank : 876)	NC score	0.087570 (rank : 415)
Query Neighborhood Hits	531	Target Neighborhood Hits	1038	Shared Neighborhood Hits	165
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PI5PA_MOUSE
θ value	θ > 10 (rank : 877)	NC score	0.072984 (rank : 522)
Query Neighborhood Hits	531	Target Neighborhood Hits	331	Shared Neighborhood Hits	92
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

PKHA6_HUMAN
θ value	θ > 10 (rank : 878)	NC score	0.057511 (rank : 712)
Query Neighborhood Hits	531	Target Neighborhood Hits	556	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 879)	NC score	0.057705 (rank : 708)
Query Neighborhood Hits	531	Target Neighborhood Hits	591	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLCD1_HUMAN
θ value	θ > 10 (rank : 880)	NC score	0.057469 (rank : 714)
Query Neighborhood Hits	531	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PLCD1_MOUSE
θ value	θ > 10 (rank : 881)	NC score	0.056965 (rank : 738)
Query Neighborhood Hits	531	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PPIP1_HUMAN
θ value	θ > 10 (rank : 882)	NC score	0.071504 (rank : 535)
Query Neighborhood Hits	531	Target Neighborhood Hits	389	Shared Neighborhood Hits	57
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 883)	NC score	0.070282 (rank : 545)
Query Neighborhood Hits	531	Target Neighborhood Hits	377	Shared Neighborhood Hits	58
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PPRB_MOUSE
θ value	θ > 10 (rank : 884)	NC score	0.051145 (rank : 868)
Query Neighborhood Hits	531	Target Neighborhood Hits	354	Shared Neighborhood Hits	82
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

PRAX_HUMAN
θ value	θ > 10 (rank : 885)	NC score	0.073996 (rank : 511)
Query Neighborhood Hits	531	Target Neighborhood Hits	215	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRAX_MOUSE
θ value	θ > 10 (rank : 886)	NC score	0.070679 (rank : 539)
Query Neighborhood Hits	531	Target Neighborhood Hits	199	Shared Neighborhood Hits	52
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

PRGC2_MOUSE
θ value	θ > 10 (rank : 887)	NC score	0.050767 (rank : 876)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VHJ7, Q8C1C0	Gene names	Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta protein) (PGC-1beta) (ERR ligand 1) (PPARGC-1-beta) (PGC-1-beta).

PRP5_HUMAN
θ value	θ > 10 (rank : 888)	NC score	0.101930 (rank : 328)
Query Neighborhood Hits	531	Target Neighborhood Hits	108	Shared Neighborhood Hits	34
SwissProt Accessions	P04281	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide IB-1.

PRPC_HUMAN
θ value	θ > 10 (rank : 889)	NC score	0.111412 (rank : 278)
Query Neighborhood Hits	531	Target Neighborhood Hits	165	Shared Neighborhood Hits	43
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

PRPE_HUMAN
θ value	θ > 10 (rank : 890)	NC score	0.059994 (rank : 648)
Query Neighborhood Hits	531	Target Neighborhood Hits	44	Shared Neighborhood Hits	13
SwissProt Accessions	P02811	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide P-E (IB-9).

PRR13_HUMAN
θ value	θ > 10 (rank : 891)	NC score	0.086993 (rank : 417)
Query Neighborhood Hits	531	Target Neighborhood Hits	105	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

PRRT1_MOUSE
θ value	θ > 10 (rank : 892)	NC score	0.051307 (rank : 863)
Query Neighborhood Hits	531	Target Neighborhood Hits	102	Shared Neighborhood Hits	32
SwissProt Accessions	O35449	Gene names	Prrt1, Ng5
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 1.

PRRT3_MOUSE
θ value	θ > 10 (rank : 893)	NC score	0.052826 (rank : 830)
Query Neighborhood Hits	531	Target Neighborhood Hits	162	Shared Neighborhood Hits	32
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

PSL1_HUMAN
θ value	θ > 10 (rank : 894)	NC score	0.147337 (rank : 156)
Query Neighborhood Hits	531	Target Neighborhood Hits	650	Shared Neighborhood Hits	204
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

PTK6_HUMAN
θ value	θ > 10 (rank : 895)	NC score	0.092521 (rank : 385)
Query Neighborhood Hits	531	Target Neighborhood Hits	1020	Shared Neighborhood Hits	90
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK7_HUMAN
θ value	θ > 10 (rank : 896)	NC score	0.055299 (rank : 782)
Query Neighborhood Hits	531	Target Neighborhood Hits	1103	Shared Neighborhood Hits	48
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

PYGO2_HUMAN
θ value	θ > 10 (rank : 897)	NC score	0.076376 (rank : 491)
Query Neighborhood Hits	531	Target Neighborhood Hits	189	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

R3HD2_MOUSE
θ value	θ > 10 (rank : 898)	NC score	0.109211 (rank : 288)
Query Neighborhood Hits	531	Target Neighborhood Hits	397	Shared Neighborhood Hits	110
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

RAF1_HUMAN
θ value	θ > 10 (rank : 899)	NC score	0.050181 (rank : 887)
Query Neighborhood Hits	531	Target Neighborhood Hits	886	Shared Neighborhood Hits	46
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RAF1_MOUSE
θ value	θ > 10 (rank : 900)	NC score	0.050012 (rank : 891)
Query Neighborhood Hits	531	Target Neighborhood Hits	886	Shared Neighborhood Hits	48
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

RBBP6_MOUSE
θ value	θ > 10 (rank : 901)	NC score	0.072726 (rank : 525)
Query Neighborhood Hits	531	Target Neighborhood Hits	1014	Shared Neighborhood Hits	123
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RBM16_HUMAN
θ value	θ > 10 (rank : 902)	NC score	0.052085 (rank : 851)
Query Neighborhood Hits	531	Target Neighborhood Hits	300	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPN6, Q5TBU6, Q9BQN8, Q9BX43	Gene names	RBM16, KIAA1116
Domain Architecture
Description	Putative RNA-binding protein 16 (RNA-binding motif protein 16).

RECQ5_HUMAN
θ value	θ > 10 (rank : 903)	NC score	0.057718 (rank : 706)
Query Neighborhood Hits	531	Target Neighborhood Hits	390	Shared Neighborhood Hits	100
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

RET_HUMAN
θ value	θ > 10 (rank : 904)	NC score	0.055520 (rank : 778)
Query Neighborhood Hits	531	Target Neighborhood Hits	873	Shared Neighborhood Hits	46
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RET_MOUSE
θ value	θ > 10 (rank : 905)	NC score	0.054927 (rank : 788)
Query Neighborhood Hits	531	Target Neighborhood Hits	884	Shared Neighborhood Hits	46
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

RIMB1_HUMAN
θ value	θ > 10 (rank : 906)	NC score	0.057740 (rank : 704)
Query Neighborhood Hits	531	Target Neighborhood Hits	1479	Shared Neighborhood Hits	166
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIN3_HUMAN
θ value	θ > 10 (rank : 907)	NC score	0.051172 (rank : 867)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

RIPK3_MOUSE
θ value	θ > 10 (rank : 908)	NC score	0.050337 (rank : 885)
Query Neighborhood Hits	531	Target Neighborhood Hits	867	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

RON_HUMAN
θ value	θ > 10 (rank : 909)	NC score	0.055791 (rank : 768)
Query Neighborhood Hits	531	Target Neighborhood Hits	842	Shared Neighborhood Hits	44
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

RON_MOUSE
θ value	θ > 10 (rank : 910)	NC score	0.056490 (rank : 754)
Query Neighborhood Hits	531	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

ROR1_HUMAN
θ value	θ > 10 (rank : 911)	NC score	0.055436 (rank : 779)
Query Neighborhood Hits	531	Target Neighborhood Hits	1018	Shared Neighborhood Hits	48
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

ROR1_MOUSE
θ value	θ > 10 (rank : 912)	NC score	0.055798 (rank : 767)
Query Neighborhood Hits	531	Target Neighborhood Hits	1025	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

ROR2_HUMAN
θ value	θ > 10 (rank : 913)	NC score	0.056224 (rank : 758)
Query Neighborhood Hits	531	Target Neighborhood Hits	1014	Shared Neighborhood Hits	47
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

ROR2_MOUSE
θ value	θ > 10 (rank : 914)	NC score	0.057844 (rank : 701)
Query Neighborhood Hits	531	Target Neighborhood Hits	1000	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ROS_HUMAN
θ value	θ > 10 (rank : 915)	NC score	0.061176 (rank : 632)
Query Neighborhood Hits	531	Target Neighborhood Hits	907	Shared Neighborhood Hits	47
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RP1L1_HUMAN
θ value	θ > 10 (rank : 916)	NC score	0.056243 (rank : 756)
Query Neighborhood Hits	531	Target Neighborhood Hits	1072	Shared Neighborhood Hits	127
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

RTP3_MOUSE
θ value	θ > 10 (rank : 917)	NC score	0.142858 (rank : 176)
Query Neighborhood Hits	531	Target Neighborhood Hits	374	Shared Neighborhood Hits	126
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

RUSC1_HUMAN
θ value	θ > 10 (rank : 918)	NC score	0.052385 (rank : 842)
Query Neighborhood Hits	531	Target Neighborhood Hits	226	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RYK_HUMAN
θ value	θ > 10 (rank : 919)	NC score	0.061567 (rank : 629)
Query Neighborhood Hits	531	Target Neighborhood Hits	701	Shared Neighborhood Hits	44
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

RYK_MOUSE
θ value	θ > 10 (rank : 920)	NC score	0.061167 (rank : 633)
Query Neighborhood Hits	531	Target Neighborhood Hits	715	Shared Neighborhood Hits	44
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SAPS1_HUMAN
θ value	θ > 10 (rank : 921)	NC score	0.157104 (rank : 135)
Query Neighborhood Hits	531	Target Neighborhood Hits	704	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SASH1_MOUSE
θ value	θ > 10 (rank : 922)	NC score	0.066639 (rank : 586)
Query Neighborhood Hits	531	Target Neighborhood Hits	263	Shared Neighborhood Hits	57
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SC24C_HUMAN
θ value	θ > 10 (rank : 923)	NC score	0.177988 (rank : 93)
Query Neighborhood Hits	531	Target Neighborhood Hits	662	Shared Neighborhood Hits	181
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SELPL_MOUSE
θ value	θ > 10 (rank : 924)	NC score	0.155835 (rank : 136)
Query Neighborhood Hits	531	Target Neighborhood Hits	588	Shared Neighborhood Hits	158
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SEPT9_HUMAN
θ value	θ > 10 (rank : 925)	NC score	0.093579 (rank : 380)
Query Neighborhood Hits	531	Target Neighborhood Hits	706	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

SETD2_HUMAN
θ value	θ > 10 (rank : 926)	NC score	0.072547 (rank : 530)
Query Neighborhood Hits	531	Target Neighborhood Hits	412	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SETD8_MOUSE
θ value	θ > 10 (rank : 927)	NC score	0.053885 (rank : 810)
Query Neighborhood Hits	531	Target Neighborhood Hits	131	Shared Neighborhood Hits	31
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

SF01_HUMAN
θ value	θ > 10 (rank : 928)	NC score	0.071298 (rank : 536)
Query Neighborhood Hits	531	Target Neighborhood Hits	287	Shared Neighborhood Hits	76
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

SF01_MOUSE
θ value	θ > 10 (rank : 929)	NC score	0.059423 (rank : 658)
Query Neighborhood Hits	531	Target Neighborhood Hits	240	Shared Neighborhood Hits	63
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

SF3A1_HUMAN
θ value	θ > 10 (rank : 930)	NC score	0.051445 (rank : 860)
Query Neighborhood Hits	531	Target Neighborhood Hits	199	Shared Neighborhood Hits	61
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

SF3B1_HUMAN
θ value	θ > 10 (rank : 931)	NC score	0.066200 (rank : 594)
Query Neighborhood Hits	531	Target Neighborhood Hits	341	Shared Neighborhood Hits	75
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	θ > 10 (rank : 932)	NC score	0.066882 (rank : 583)
Query Neighborhood Hits	531	Target Neighborhood Hits	352	Shared Neighborhood Hits	78
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SFR15_HUMAN
θ value	θ > 10 (rank : 933)	NC score	0.092300 (rank : 387)
Query Neighborhood Hits	531	Target Neighborhood Hits	368	Shared Neighborhood Hits	88
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SFRIP_HUMAN
θ value	θ > 10 (rank : 934)	NC score	0.078044 (rank : 481)
Query Neighborhood Hits	531	Target Neighborhood Hits	530	Shared Neighborhood Hits	86
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

SGIP1_MOUSE
θ value	θ > 10 (rank : 935)	NC score	0.069478 (rank : 553)
Query Neighborhood Hits	531	Target Neighborhood Hits	180	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VD37, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q9CXT2	Gene names	Sgip1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SH22A_HUMAN
θ value	θ > 10 (rank : 936)	NC score	0.102041 (rank : 326)
Query Neighborhood Hits	531	Target Neighborhood Hits	144	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 937)	NC score	0.125545 (rank : 223)
Query Neighborhood Hits	531	Target Neighborhood Hits	179	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH24A_HUMAN
θ value	θ > 10 (rank : 938)	NC score	0.133449 (rank : 200)
Query Neighborhood Hits	531	Target Neighborhood Hits	455	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 939)	NC score	0.090116 (rank : 400)
Query Neighborhood Hits	531	Target Neighborhood Hits	326	Shared Neighborhood Hits	67
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 940)	NC score	0.111349 (rank : 279)
Query Neighborhood Hits	531	Target Neighborhood Hits	188	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 941)	NC score	0.111051 (rank : 282)
Query Neighborhood Hits	531	Target Neighborhood Hits	174	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SH3G2_HUMAN
θ value	θ > 10 (rank : 942)	NC score	0.052523 (rank : 838)
Query Neighborhood Hits	531	Target Neighborhood Hits	324	Shared Neighborhood Hits	52
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 943)	NC score	0.052069 (rank : 852)
Query Neighborhood Hits	531	Target Neighborhood Hits	319	Shared Neighborhood Hits	51
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_MOUSE
θ value	θ > 10 (rank : 944)	NC score	0.050918 (rank : 873)
Query Neighborhood Hits	531	Target Neighborhood Hits	236	Shared Neighborhood Hits	47
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3K1_HUMAN
θ value	θ > 10 (rank : 945)	NC score	0.089451 (rank : 404)
Query Neighborhood Hits	531	Target Neighborhood Hits	341	Shared Neighborhood Hits	62
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 946)	NC score	0.089298 (rank : 405)
Query Neighborhood Hits	531	Target Neighborhood Hits	332	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 947)	NC score	0.077857 (rank : 484)
Query Neighborhood Hits	531	Target Neighborhood Hits	446	Shared Neighborhood Hits	77
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SHB_HUMAN
θ value	θ > 10 (rank : 948)	NC score	0.135965 (rank : 194)
Query Neighborhood Hits	531	Target Neighborhood Hits	141	Shared Neighborhood Hits	69
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 949)	NC score	0.137322 (rank : 187)
Query Neighborhood Hits	531	Target Neighborhood Hits	137	Shared Neighborhood Hits	69
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_MOUSE
θ value	θ > 10 (rank : 950)	NC score	0.127305 (rank : 218)
Query Neighborhood Hits	531	Target Neighborhood Hits	137	Shared Neighborhood Hits	69
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 951)	NC score	0.161473 (rank : 126)
Query Neighborhood Hits	531	Target Neighborhood Hits	164	Shared Neighborhood Hits	79
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 952)	NC score	0.159225 (rank : 133)
Query Neighborhood Hits	531	Target Neighborhood Hits	169	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 953)	NC score	0.173877 (rank : 103)
Query Neighborhood Hits	531	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 954)	NC score	0.175595 (rank : 99)
Query Neighborhood Hits	531	Target Neighborhood Hits	117	Shared Neighborhood Hits	61
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 955)	NC score	0.183644 (rank : 82)
Query Neighborhood Hits	531	Target Neighborhood Hits	139	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 956)	NC score	0.188047 (rank : 79)
Query Neighborhood Hits	531	Target Neighborhood Hits	136	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SMOO_HUMAN
θ value	θ > 10 (rank : 957)	NC score	0.061082 (rank : 634)
Query Neighborhood Hits	531	Target Neighborhood Hits	391	Shared Neighborhood Hits	85
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

SMRC2_HUMAN
θ value	θ > 10 (rank : 958)	NC score	0.058512 (rank : 683)
Query Neighborhood Hits	531	Target Neighborhood Hits	499	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

SNPC4_MOUSE
θ value	θ > 10 (rank : 959)	NC score	0.062087 (rank : 623)
Query Neighborhood Hits	531	Target Neighborhood Hits	237	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

SOCS1_HUMAN
θ value	θ > 10 (rank : 960)	NC score	0.077123 (rank : 488)
Query Neighborhood Hits	531	Target Neighborhood Hits	79	Shared Neighborhood Hits	34
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

SOCS1_MOUSE
θ value	θ > 10 (rank : 961)	NC score	0.079979 (rank : 465)
Query Neighborhood Hits	531	Target Neighborhood Hits	82	Shared Neighborhood Hits	33
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

SOCS3_HUMAN
θ value	θ > 10 (rank : 962)	NC score	0.096883 (rank : 359)
Query Neighborhood Hits	531	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

SOCS3_MOUSE
θ value	θ > 10 (rank : 963)	NC score	0.095362 (rank : 373)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	39
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

SOCS4_HUMAN
θ value	θ > 10 (rank : 964)	NC score	0.061687 (rank : 627)
Query Neighborhood Hits	531	Target Neighborhood Hits	69	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS4_MOUSE
θ value	θ > 10 (rank : 965)	NC score	0.062370 (rank : 618)
Query Neighborhood Hits	531	Target Neighborhood Hits	69	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

SOCS5_HUMAN
θ value	θ > 10 (rank : 966)	NC score	0.069244 (rank : 556)
Query Neighborhood Hits	531	Target Neighborhood Hits	91	Shared Neighborhood Hits	41
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

SOCS5_MOUSE
θ value	θ > 10 (rank : 967)	NC score	0.068671 (rank : 566)
Query Neighborhood Hits	531	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SON_MOUSE
θ value	θ > 10 (rank : 968)	NC score	0.145134 (rank : 165)
Query Neighborhood Hits	531	Target Neighborhood Hits	957	Shared Neighborhood Hits	196
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SOX13_HUMAN
θ value	θ > 10 (rank : 969)	NC score	0.097657 (rank : 356)
Query Neighborhood Hits	531	Target Neighborhood Hits	464	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

SOX13_MOUSE
θ value	θ > 10 (rank : 970)	NC score	0.085894 (rank : 423)
Query Neighborhood Hits	531	Target Neighborhood Hits	495	Shared Neighborhood Hits	150
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

SOX30_HUMAN
θ value	θ > 10 (rank : 971)	NC score	0.058026 (rank : 696)
Query Neighborhood Hits	531	Target Neighborhood Hits	305	Shared Neighborhood Hits	79
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

SPEG_HUMAN
θ value	θ > 10 (rank : 972)	NC score	0.058529 (rank : 682)
Query Neighborhood Hits	531	Target Neighborhood Hits	1762	Shared Neighborhood Hits	192
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SPN90_HUMAN
θ value	θ > 10 (rank : 973)	NC score	0.082311 (rank : 445)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 974)	NC score	0.081040 (rank : 458)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	46
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPR1A_MOUSE
θ value	θ > 10 (rank : 975)	NC score	0.143235 (rank : 173)
Query Neighborhood Hits	531	Target Neighborhood Hits	343	Shared Neighborhood Hits	139
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SPR1B_MOUSE
θ value	θ > 10 (rank : 976)	NC score	0.179493 (rank : 91)
Query Neighborhood Hits	531	Target Neighborhood Hits	395	Shared Neighborhood Hits	155
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SPRR3_HUMAN
θ value	θ > 10 (rank : 977)	NC score	0.082835 (rank : 441)
Query Neighborhood Hits	531	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UBC9, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3	Gene names	SPRR3, SPRC
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta) (Esophagin) (22 kDa pancornulin).

SPRR3_MOUSE
θ value	θ > 10 (rank : 978)	NC score	0.058705 (rank : 673)
Query Neighborhood Hits	531	Target Neighborhood Hits	106	Shared Neighborhood Hits	27
SwissProt Accessions	O09116	Gene names	Sprr3
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta).

SPT5H_HUMAN
θ value	θ > 10 (rank : 979)	NC score	0.133130 (rank : 202)
Query Neighborhood Hits	531	Target Neighborhood Hits	436	Shared Neighborhood Hits	131
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

SPT5H_MOUSE
θ value	θ > 10 (rank : 980)	NC score	0.133889 (rank : 199)
Query Neighborhood Hits	531	Target Neighborhood Hits	437	Shared Neighborhood Hits	130
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SRBS1_HUMAN
θ value	θ > 10 (rank : 981)	NC score	0.081762 (rank : 451)
Query Neighborhood Hits	531	Target Neighborhood Hits	396	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	θ > 10 (rank : 982)	NC score	0.087664 (rank : 414)
Query Neighborhood Hits	531	Target Neighborhood Hits	409	Shared Neighborhood Hits	92
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRC8_HUMAN
θ value	θ > 10 (rank : 983)	NC score	0.068338 (rank : 567)
Query Neighborhood Hits	531	Target Neighborhood Hits	269	Shared Neighborhood Hits	51
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 984)	NC score	0.068114 (rank : 569)
Query Neighborhood Hits	531	Target Neighborhood Hits	292	Shared Neighborhood Hits	59
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRMS_HUMAN
θ value	θ > 10 (rank : 985)	NC score	0.092990 (rank : 384)
Query Neighborhood Hits	531	Target Neighborhood Hits	946	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 986)	NC score	0.096342 (rank : 365)
Query Neighborhood Hits	531	Target Neighborhood Hits	964	Shared Neighborhood Hits	87
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

SSBP4_HUMAN
θ value	θ > 10 (rank : 987)	NC score	0.167508 (rank : 117)
Query Neighborhood Hits	531	Target Neighborhood Hits	753	Shared Neighborhood Hits	194
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

STAC3_HUMAN
θ value	θ > 10 (rank : 988)	NC score	0.075086 (rank : 501)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 989)	NC score	0.074766 (rank : 505)
Query Neighborhood Hits	531	Target Neighborhood Hits	232	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 990)	NC score	0.067049 (rank : 580)
Query Neighborhood Hits	531	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 991)	NC score	0.069799 (rank : 550)
Query Neighborhood Hits	531	Target Neighborhood Hits	268	Shared Neighborhood Hits	49
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 992)	NC score	0.077919 (rank : 482)
Query Neighborhood Hits	531	Target Neighborhood Hits	271	Shared Neighborhood Hits	57
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 993)	NC score	0.081036 (rank : 459)
Query Neighborhood Hits	531	Target Neighborhood Hits	273	Shared Neighborhood Hits	59
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 994)	NC score	0.082234 (rank : 447)
Query Neighborhood Hits	531	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 995)	NC score	0.081558 (rank : 455)
Query Neighborhood Hits	531	Target Neighborhood Hits	285	Shared Neighborhood Hits	56
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

STYK1_HUMAN
θ value	θ > 10 (rank : 996)	NC score	0.060434 (rank : 642)
Query Neighborhood Hits	531	Target Neighborhood Hits	786	Shared Neighborhood Hits	43
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

STYK1_MOUSE
θ value	θ > 10 (rank : 997)	NC score	0.060971 (rank : 635)
Query Neighborhood Hits	531	Target Neighborhood Hits	779	Shared Neighborhood Hits	44
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

SYN1_HUMAN
θ value	θ > 10 (rank : 998)	NC score	0.098996 (rank : 350)
Query Neighborhood Hits	531	Target Neighborhood Hits	419	Shared Neighborhood Hits	107
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

SYN1_MOUSE
θ value	θ > 10 (rank : 999)	NC score	0.078781 (rank : 472)
Query Neighborhood Hits	531	Target Neighborhood Hits	363	Shared Neighborhood Hits	96
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

SYNPO_MOUSE
θ value	θ > 10 (rank : 1000)	NC score	0.085320 (rank : 424)
Query Neighborhood Hits	531	Target Neighborhood Hits	242	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

T22D2_HUMAN
θ value	θ > 10 (rank : 1001)	NC score	0.066227 (rank : 593)
Query Neighborhood Hits	531	Target Neighborhood Hits	250	Shared Neighborhood Hits	64
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

TACC2_HUMAN
θ value	θ > 10 (rank : 1002)	NC score	0.052856 (rank : 829)
Query Neighborhood Hits	531	Target Neighborhood Hits	856	Shared Neighborhood Hits	109
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TAF3_HUMAN
θ value	θ > 10 (rank : 1003)	NC score	0.052927 (rank : 827)
Query Neighborhood Hits	531	Target Neighborhood Hits	568	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

TAF4_HUMAN
θ value	θ > 10 (rank : 1004)	NC score	0.102021 (rank : 327)
Query Neighborhood Hits	531	Target Neighborhood Hits	687	Shared Neighborhood Hits	120
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

TARA_MOUSE
θ value	θ > 10 (rank : 1005)	NC score	0.113818 (rank : 265)
Query Neighborhood Hits	531	Target Neighborhood Hits	1133	Shared Neighborhood Hits	170
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TAU_HUMAN
θ value	θ > 10 (rank : 1006)	NC score	0.085253 (rank : 425)
Query Neighborhood Hits	531	Target Neighborhood Hits	448	Shared Neighborhood Hits	111
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

TB182_HUMAN
θ value	θ > 10 (rank : 1007)	NC score	0.055631 (rank : 772)
Query Neighborhood Hits	531	Target Neighborhood Hits	414	Shared Neighborhood Hits	68
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

TCF20_HUMAN
θ value	θ > 10 (rank : 1008)	NC score	0.060826 (rank : 636)
Query Neighborhood Hits	531	Target Neighborhood Hits	323	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TCF20_MOUSE
θ value	θ > 10 (rank : 1009)	NC score	0.065027 (rank : 602)
Query Neighborhood Hits	531	Target Neighborhood Hits	396	Shared Neighborhood Hits	67
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

TCGAP_HUMAN
θ value	θ > 10 (rank : 1010)	NC score	0.154656 (rank : 138)
Query Neighborhood Hits	531	Target Neighborhood Hits	872	Shared Neighborhood Hits	216
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCOF_HUMAN
θ value	θ > 10 (rank : 1011)	NC score	0.070085 (rank : 549)
Query Neighborhood Hits	531	Target Neighborhood Hits	543	Shared Neighborhood Hits	81
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TENS4_HUMAN
θ value	θ > 10 (rank : 1012)	NC score	0.101836 (rank : 329)
Query Neighborhood Hits	531	Target Neighborhood Hits	214	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TENS4_MOUSE
θ value	θ > 10 (rank : 1013)	NC score	0.096273 (rank : 366)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

TEX14_HUMAN
θ value	θ > 10 (rank : 1014)	NC score	0.072561 (rank : 529)
Query Neighborhood Hits	531	Target Neighborhood Hits	1103	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_MOUSE
θ value	θ > 10 (rank : 1015)	NC score	0.066755 (rank : 584)
Query Neighborhood Hits	531	Target Neighborhood Hits	1333	Shared Neighborhood Hits	98
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TGON2_MOUSE
θ value	θ > 10 (rank : 1016)	NC score	0.052461 (rank : 840)
Query Neighborhood Hits	531	Target Neighborhood Hits	277	Shared Neighborhood Hits	61
SwissProt Accessions	Q62314	Gene names	Tgoln2, Ttgn2
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 2 precursor (TGN38B).

TIE1_HUMAN
θ value	θ > 10 (rank : 1017)	NC score	0.052136 (rank : 848)
Query Neighborhood Hits	531	Target Neighborhood Hits	1241	Shared Neighborhood Hits	55
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE1_MOUSE
θ value	θ > 10 (rank : 1018)	NC score	0.052099 (rank : 850)
Query Neighborhood Hits	531	Target Neighborhood Hits	1266	Shared Neighborhood Hits	54
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

TIE2_HUMAN
θ value	θ > 10 (rank : 1019)	NC score	0.051892 (rank : 854)
Query Neighborhood Hits	531	Target Neighborhood Hits	1192	Shared Neighborhood Hits	54
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	θ > 10 (rank : 1020)	NC score	0.052365 (rank : 844)
Query Neighborhood Hits	531	Target Neighborhood Hits	1204	Shared Neighborhood Hits	54
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

TM108_MOUSE
θ value	θ > 10 (rank : 1021)	NC score	0.096577 (rank : 362)
Query Neighborhood Hits	531	Target Neighborhood Hits	336	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

TNK1_HUMAN
θ value	θ > 10 (rank : 1022)	NC score	0.061581 (rank : 628)
Query Neighborhood Hits	531	Target Neighborhood Hits	815	Shared Neighborhood Hits	55
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

TNK1_MOUSE
θ value	θ > 10 (rank : 1023)	NC score	0.059699 (rank : 651)
Query Neighborhood Hits	531	Target Neighborhood Hits	806	Shared Neighborhood Hits	54
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

TP53B_MOUSE
θ value	θ > 10 (rank : 1024)	NC score	0.099506 (rank : 345)
Query Neighborhood Hits	531	Target Neighborhood Hits	644	Shared Neighborhood Hits	122
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TPO_MOUSE
θ value	θ > 10 (rank : 1025)	NC score	0.123761 (rank : 227)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	104
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

TRI66_MOUSE
θ value	θ > 10 (rank : 1026)	NC score	0.053775 (rank : 812)
Query Neighborhood Hits	531	Target Neighborhood Hits	491	Shared Neighborhood Hits	97
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

TTBK1_HUMAN
θ value	θ > 10 (rank : 1027)	NC score	0.050660 (rank : 878)
Query Neighborhood Hits	531	Target Neighborhood Hits	1058	Shared Neighborhood Hits	109
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

TULP4_HUMAN
θ value	θ > 10 (rank : 1028)	NC score	0.113937 (rank : 264)
Query Neighborhood Hits	531	Target Neighborhood Hits	426	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

TXND2_HUMAN
θ value	θ > 10 (rank : 1029)	NC score	0.147432 (rank : 155)
Query Neighborhood Hits	531	Target Neighborhood Hits	793	Shared Neighborhood Hits	163
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

TXND2_MOUSE
θ value	θ > 10 (rank : 1030)	NC score	0.073573 (rank : 515)
Query Neighborhood Hits	531	Target Neighborhood Hits	828	Shared Neighborhood Hits	91
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

TYK2_HUMAN
θ value	θ > 10 (rank : 1031)	NC score	0.050940 (rank : 872)
Query Neighborhood Hits	531	Target Neighborhood Hits	841	Shared Neighborhood Hits	44
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYK2_MOUSE
θ value	θ > 10 (rank : 1032)	NC score	0.054312 (rank : 805)
Query Neighborhood Hits	531	Target Neighborhood Hits	850	Shared Neighborhood Hits	49
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

TYRO3_HUMAN
θ value	θ > 10 (rank : 1033)	NC score	0.055805 (rank : 766)
Query Neighborhood Hits	531	Target Neighborhood Hits	995	Shared Neighborhood Hits	49
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

TYRO3_MOUSE
θ value	θ > 10 (rank : 1034)	NC score	0.056060 (rank : 760)
Query Neighborhood Hits	531	Target Neighborhood Hits	1007	Shared Neighborhood Hits	51
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

UFO_HUMAN
θ value	θ > 10 (rank : 1035)	NC score	0.057346 (rank : 718)
Query Neighborhood Hits	531	Target Neighborhood Hits	981	Shared Neighborhood Hits	59
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

UFO_MOUSE
θ value	θ > 10 (rank : 1036)	NC score	0.057120 (rank : 730)
Query Neighborhood Hits	531	Target Neighborhood Hits	988	Shared Neighborhood Hits	54
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

VASP_HUMAN
θ value	θ > 10 (rank : 1037)	NC score	0.065954 (rank : 597)
Query Neighborhood Hits	531	Target Neighborhood Hits	201	Shared Neighborhood Hits	52
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

VASP_MOUSE
θ value	θ > 10 (rank : 1038)	NC score	0.056812 (rank : 744)
Query Neighborhood Hits	531	Target Neighborhood Hits	195	Shared Neighborhood Hits	49
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

VAV2_HUMAN
θ value	θ > 10 (rank : 1039)	NC score	0.131669 (rank : 206)
Query Neighborhood Hits	531	Target Neighborhood Hits	453	Shared Neighborhood Hits	93
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 1040)	NC score	0.131610 (rank : 207)
Query Neighborhood Hits	531	Target Neighborhood Hits	456	Shared Neighborhood Hits	97
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 1041)	NC score	0.145192 (rank : 164)
Query Neighborhood Hits	531	Target Neighborhood Hits	398	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 1042)	NC score	0.136687 (rank : 192)
Query Neighborhood Hits	531	Target Neighborhood Hits	452	Shared Neighborhood Hits	87
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 1043)	NC score	0.130427 (rank : 209)
Query Neighborhood Hits	531	Target Neighborhood Hits	430	Shared Neighborhood Hits	85
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VGFR1_HUMAN
θ value	θ > 10 (rank : 1044)	NC score	0.051871 (rank : 855)
Query Neighborhood Hits	531	Target Neighborhood Hits	1109	Shared Neighborhood Hits	48
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

VGFR1_MOUSE
θ value	θ > 10 (rank : 1045)	NC score	0.051219 (rank : 866)
Query Neighborhood Hits	531	Target Neighborhood Hits	1118	Shared Neighborhood Hits	48
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

VGFR2_HUMAN
θ value	θ > 10 (rank : 1046)	NC score	0.052988 (rank : 826)
Query Neighborhood Hits	531	Target Neighborhood Hits	1103	Shared Neighborhood Hits	52
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

VGFR2_MOUSE
θ value	θ > 10 (rank : 1047)	NC score	0.052215 (rank : 847)
Query Neighborhood Hits	531	Target Neighborhood Hits	1089	Shared Neighborhood Hits	50
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

VGFR3_HUMAN
θ value	θ > 10 (rank : 1048)	NC score	0.052754 (rank : 832)
Query Neighborhood Hits	531	Target Neighborhood Hits	1037	Shared Neighborhood Hits	47
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGFR3_MOUSE
θ value	θ > 10 (rank : 1049)	NC score	0.053288 (rank : 820)
Query Neighborhood Hits	531	Target Neighborhood Hits	1056	Shared Neighborhood Hits	48
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

VGF_HUMAN
θ value	θ > 10 (rank : 1050)	NC score	0.063461 (rank : 612)
Query Neighborhood Hits	531	Target Neighborhood Hits	167	Shared Neighborhood Hits	24
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

VINEX_HUMAN
θ value	θ > 10 (rank : 1051)	NC score	0.073479 (rank : 519)
Query Neighborhood Hits	531	Target Neighborhood Hits	270	Shared Neighborhood Hits	56
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 1052)	NC score	0.075185 (rank : 500)
Query Neighborhood Hits	531	Target Neighborhood Hits	286	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

WASF3_MOUSE
θ value	θ > 10 (rank : 1053)	NC score	0.118960 (rank : 247)
Query Neighborhood Hits	531	Target Neighborhood Hits	188	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

WBS14_MOUSE
θ value	θ > 10 (rank : 1054)	NC score	0.055385 (rank : 780)
Query Neighborhood Hits	531	Target Neighborhood Hits	171	Shared Neighborhood Hits	47
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

WNK1_HUMAN
θ value	θ > 10 (rank : 1055)	NC score	0.050154 (rank : 888)
Query Neighborhood Hits	531	Target Neighborhood Hits	1158	Shared Neighborhood Hits	120
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

WNK1_MOUSE
θ value	θ > 10 (rank : 1056)	NC score	0.052110 (rank : 849)
Query Neighborhood Hits	531	Target Neighborhood Hits	1179	Shared Neighborhood Hits	124
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

WNK2_HUMAN
θ value	θ > 10 (rank : 1057)	NC score	0.067600 (rank : 576)
Query Neighborhood Hits	531	Target Neighborhood Hits	1407	Shared Neighborhood Hits	193
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

ZAN_HUMAN
θ value	θ > 10 (rank : 1058)	NC score	0.050458 (rank : 883)
Query Neighborhood Hits	531	Target Neighborhood Hits	679	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

ZIMP7_HUMAN
θ value	θ > 10 (rank : 1059)	NC score	0.081596 (rank : 454)
Query Neighborhood Hits	531	Target Neighborhood Hits	290	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZIMP7_MOUSE
θ value	θ > 10 (rank : 1060)	NC score	0.159904 (rank : 130)
Query Neighborhood Hits	531	Target Neighborhood Hits	566	Shared Neighborhood Hits	158
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

ZN385_HUMAN
θ value	θ > 10 (rank : 1061)	NC score	0.114321 (rank : 261)
Query Neighborhood Hits	531	Target Neighborhood Hits	614	Shared Neighborhood Hits	155
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

ZN645_HUMAN
θ value	θ > 10 (rank : 1062)	NC score	0.134320 (rank : 198)
Query Neighborhood Hits	531	Target Neighborhood Hits	265	Shared Neighborhood Hits	102
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

ZN750_MOUSE
θ value	θ > 10 (rank : 1063)	NC score	0.097994 (rank : 354)
Query Neighborhood Hits	531	Target Neighborhood Hits	346	Shared Neighborhood Hits	95
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

ZYX_HUMAN
θ value	θ > 10 (rank : 1064)	NC score	0.053569 (rank : 815)
Query Neighborhood Hits	531	Target Neighborhood Hits	387	Shared Neighborhood Hits	71
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

Hits sorted by NC score

LCP2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	531	Target Neighborhood Hits	531	Shared Neighborhood Hits	531
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
NC score	0.806570 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	531	Target Neighborhood Hits	177	Shared Neighborhood Hits	127
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BLNK_MOUSE
NC score	0.586558 (rank : 3)	θ value	2.77775e-25 (rank : 3)
Query Neighborhood Hits	531	Target Neighborhood Hits	296	Shared Neighborhood Hits	142
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

BLNK_HUMAN
NC score	0.551823 (rank : 4)	θ value	8.08199e-25 (rank : 4)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	96
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

NCOA6_HUMAN
NC score	0.326547 (rank : 5)	θ value	3.19293e-05 (rank : 14)
Query Neighborhood Hits	531	Target Neighborhood Hits	1202	Shared Neighborhood Hits	298
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

DAPP1_HUMAN
NC score	0.315183 (rank : 6)	θ value	1.09739e-05 (rank : 10)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PRRT3_HUMAN
NC score	0.311008 (rank : 7)	θ value	0.00869519 (rank : 68)
Query Neighborhood Hits	531	Target Neighborhood Hits	998	Shared Neighborhood Hits	262
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

DAPP1_MOUSE
NC score	0.307550 (rank : 8)	θ value	3.19293e-05 (rank : 13)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

NCK1_HUMAN
NC score	0.289507 (rank : 9)	θ value	3.77169e-06 (rank : 9)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	86
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
NC score	0.288537 (rank : 10)	θ value	5.44631e-05 (rank : 16)
Query Neighborhood Hits	531	Target Neighborhood Hits	310	Shared Neighborhood Hits	94
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

WASIP_HUMAN
NC score	0.287889 (rank : 11)	θ value	2.21117e-06 (rank : 8)
Query Neighborhood Hits	531	Target Neighborhood Hits	458	Shared Neighborhood Hits	121
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

PLCG1_HUMAN
NC score	0.284236 (rank : 12)	θ value	1.17247e-07 (rank : 5)
Query Neighborhood Hits	531	Target Neighborhood Hits	293	Shared Neighborhood Hits	84
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
NC score	0.282660 (rank : 13)	θ value	1.17247e-07 (rank : 6)
Query Neighborhood Hits	531	Target Neighborhood Hits	314	Shared Neighborhood Hits	88
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NCOA6_MOUSE
NC score	0.278267 (rank : 14)	θ value	0.000786445 (rank : 34)
Query Neighborhood Hits	531	Target Neighborhood Hits	1076	Shared Neighborhood Hits	261
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

SHC3_MOUSE
NC score	0.274349 (rank : 15)	θ value	2.44474e-05 (rank : 12)
Query Neighborhood Hits	531	Target Neighborhood Hits	151	Shared Neighborhood Hits	77
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SRRM1_MOUSE
NC score	0.268043 (rank : 16)	θ value	0.00035302 (rank : 31)
Query Neighborhood Hits	531	Target Neighborhood Hits	966	Shared Neighborhood Hits	216
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

PLCG2_HUMAN
NC score	0.267665 (rank : 17)	θ value	0.00020696 (rank : 25)
Query Neighborhood Hits	531	Target Neighborhood Hits	280	Shared Neighborhood Hits	83
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

BCL9_HUMAN
NC score	0.267431 (rank : 18)	θ value	0.163984 (rank : 159)
Query Neighborhood Hits	531	Target Neighborhood Hits	1008	Shared Neighborhood Hits	252
SwissProt Accessions	O00512	Gene names	BCL9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9) (Legless homolog).

SHC3_HUMAN
NC score	0.264028 (rank : 19)	θ value	0.000158464 (rank : 23)
Query Neighborhood Hits	531	Target Neighborhood Hits	155	Shared Neighborhood Hits	76
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

WASIP_MOUSE
NC score	0.261691 (rank : 20)	θ value	9.29e-05 (rank : 19)
Query Neighborhood Hits	531	Target Neighborhood Hits	392	Shared Neighborhood Hits	113
SwissProt Accessions	Q8K1I7, Q3U0U8	Gene names	Waspip, Wip
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein).

RGS3_MOUSE
NC score	0.261608 (rank : 21)	θ value	0.000786445 (rank : 37)
Query Neighborhood Hits	531	Target Neighborhood Hits	1621	Shared Neighborhood Hits	333
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

MLL3_HUMAN
NC score	0.258024 (rank : 22)	θ value	0.125558 (rank : 153)
Query Neighborhood Hits	531	Target Neighborhood Hits	1644	Shared Neighborhood Hits	294
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

NACAM_MOUSE
NC score	0.258004 (rank : 23)	θ value	θ > 10 (rank : 828)
Query Neighborhood Hits	531	Target Neighborhood Hits	1866	Shared Neighborhood Hits	323
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

GRAP_MOUSE
NC score	0.254105 (rank : 24)	θ value	0.00134147 (rank : 40)
Query Neighborhood Hits	531	Target Neighborhood Hits	309	Shared Neighborhood Hits	88
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.253789 (rank : 25)	θ value	0.00175202 (rank : 42)
Query Neighborhood Hits	531	Target Neighborhood Hits	307	Shared Neighborhood Hits	89
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

MUC1_HUMAN
NC score	0.251340 (rank : 26)	θ value	θ > 10 (rank : 820)
Query Neighborhood Hits	531	Target Neighborhood Hits	975	Shared Neighborhood Hits	230
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

FA47A_HUMAN
NC score	0.249713 (rank : 27)	θ value	0.125558 (rank : 149)
Query Neighborhood Hits	531	Target Neighborhood Hits	451	Shared Neighborhood Hits	171
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

MISS_MOUSE
NC score	0.248450 (rank : 28)	θ value	0.00228821 (rank : 48)
Query Neighborhood Hits	531	Target Neighborhood Hits	444	Shared Neighborhood Hits	149
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

SHC2_MOUSE
NC score	0.246416 (rank : 29)	θ value	0.00665767 (rank : 63)
Query Neighborhood Hits	531	Target Neighborhood Hits	144	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SON_HUMAN
NC score	0.244691 (rank : 30)	θ value	4.03905 (rank : 419)
Query Neighborhood Hits	531	Target Neighborhood Hits	1568	Shared Neighborhood Hits	300
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

MDC1_MOUSE
NC score	0.243489 (rank : 31)	θ value	θ > 10 (rank : 808)
Query Neighborhood Hits	531	Target Neighborhood Hits	998	Shared Neighborhood Hits	233
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MLL3_MOUSE
NC score	0.241366 (rank : 32)	θ value	0.00020696 (rank : 24)
Query Neighborhood Hits	531	Target Neighborhood Hits	1399	Shared Neighborhood Hits	253
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

TARSH_HUMAN
NC score	0.240172 (rank : 33)	θ value	1.81305 (rank : 332)
Query Neighborhood Hits	531	Target Neighborhood Hits	768	Shared Neighborhood Hits	231
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

SHC2_HUMAN
NC score	0.239911 (rank : 34)	θ value	0.0252991 (rank : 105)
Query Neighborhood Hits	531	Target Neighborhood Hits	170	Shared Neighborhood Hits	82
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

OGFR_HUMAN
NC score	0.237655 (rank : 35)	θ value	θ > 10 (rank : 853)
Query Neighborhood Hits	531	Target Neighborhood Hits	1582	Shared Neighborhood Hits	296
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

SHC1_MOUSE
NC score	0.237249 (rank : 36)	θ value	0.0252991 (rank : 104)
Query Neighborhood Hits	531	Target Neighborhood Hits	180	Shared Neighborhood Hits	85
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

FA47B_HUMAN
NC score	0.231944 (rank : 37)	θ value	5.27518 (rank : 434)
Query Neighborhood Hits	531	Target Neighborhood Hits	431	Shared Neighborhood Hits	163
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

RASA1_HUMAN
NC score	0.230973 (rank : 38)	θ value	0.0252991 (rank : 103)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	79
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SRRM1_HUMAN
NC score	0.230767 (rank : 39)	θ value	2.21117e-06 (rank : 7)
Query Neighborhood Hits	531	Target Neighborhood Hits	690	Shared Neighborhood Hits	135
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

GRB2_MOUSE
NC score	0.229713 (rank : 40)	θ value	0.21417 (rank : 177)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	92
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRB2_HUMAN
NC score	0.229274 (rank : 41)	θ value	0.21417 (rank : 176)
Query Neighborhood Hits	531	Target Neighborhood Hits	310	Shared Neighborhood Hits	90
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

SH21B_HUMAN
NC score	0.229200 (rank : 42)	θ value	0.0736092 (rank : 134)
Query Neighborhood Hits	531	Target Neighborhood Hits	101	Shared Neighborhood Hits	58
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHC1_HUMAN
NC score	0.228910 (rank : 43)	θ value	0.21417 (rank : 181)
Query Neighborhood Hits	531	Target Neighborhood Hits	170	Shared Neighborhood Hits	79
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

K1802_MOUSE
NC score	0.227522 (rank : 44)	θ value	0.0193708 (rank : 91)
Query Neighborhood Hits	531	Target Neighborhood Hits	1596	Shared Neighborhood Hits	276
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

CEL_HUMAN
NC score	0.223597 (rank : 45)	θ value	0.00035302 (rank : 30)
Query Neighborhood Hits	531	Target Neighborhood Hits	896	Shared Neighborhood Hits	229
SwissProt Accessions	P19835, Q16398	Gene names	CEL, BAL
Domain Architecture
Description	Bile salt-activated lipase precursor (EC 3.1.1.3) (EC 3.1.1.13) (BAL) (Bile salt-stimulated lipase) (BSSL) (Carboxyl ester lipase) (Sterol esterase) (Cholesterol esterase) (Pancreatic lysophospholipase).

SH21B_MOUSE
NC score	0.222231 (rank : 46)	θ value	0.279714 (rank : 206)
Query Neighborhood Hits	531	Target Neighborhood Hits	101	Shared Neighborhood Hits	56
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

FYB_HUMAN
NC score	0.221720 (rank : 47)	θ value	0.00228821 (rank : 47)
Query Neighborhood Hits	531	Target Neighborhood Hits	379	Shared Neighborhood Hits	113
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

BCL9_MOUSE
NC score	0.221524 (rank : 48)	θ value	0.0563607 (rank : 118)
Query Neighborhood Hits	531	Target Neighborhood Hits	770	Shared Neighborhood Hits	208
SwissProt Accessions	Q9D219, Q67FX9, Q8BUJ8, Q8VE74	Gene names	Bcl9
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 9 protein (Bcl-9).

MDC1_HUMAN
NC score	0.219751 (rank : 49)	θ value	θ > 10 (rank : 807)
Query Neighborhood Hits	531	Target Neighborhood Hits	1446	Shared Neighborhood Hits	239
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MAGE1_HUMAN
NC score	0.217695 (rank : 50)	θ value	0.0563607 (rank : 122)
Query Neighborhood Hits	531	Target Neighborhood Hits	1389	Shared Neighborhood Hits	283
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

ARI1B_HUMAN
NC score	0.214210 (rank : 51)	θ value	4.1701e-05 (rank : 15)
Query Neighborhood Hits	531	Target Neighborhood Hits	567	Shared Neighborhood Hits	159
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

PCLO_HUMAN
NC score	0.213328 (rank : 52)	θ value	0.000786445 (rank : 35)
Query Neighborhood Hits	531	Target Neighborhood Hits	2046	Shared Neighborhood Hits	315
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

WASL_MOUSE
NC score	0.210944 (rank : 53)	θ value	0.00390308 (rank : 58)
Query Neighborhood Hits	531	Target Neighborhood Hits	339	Shared Neighborhood Hits	100
SwissProt Accessions	Q91YD9	Gene names	Wasl
Domain Architecture	No domain graphic available
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

RGS3_HUMAN
NC score	0.210482 (rank : 54)	θ value	0.279714 (rank : 202)
Query Neighborhood Hits	531	Target Neighborhood Hits	1375	Shared Neighborhood Hits	284
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

CD2_HUMAN
NC score	0.207751 (rank : 55)	θ value	1.81305 (rank : 317)
Query Neighborhood Hits	531	Target Neighborhood Hits	504	Shared Neighborhood Hits	178
SwissProt Accessions	P06729, Q96TE5	Gene names	CD2
Domain Architecture
Description	T-cell surface antigen CD2 precursor (T-cell surface antigen T11/Leu- 5) (LFA-2) (LFA-3 receptor) (Erythrocyte receptor) (Rosette receptor).

P85B_HUMAN
NC score	0.206436 (rank : 56)	θ value	0.0961366 (rank : 143)
Query Neighborhood Hits	531	Target Neighborhood Hits	543	Shared Neighborhood Hits	99
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

CRKL_MOUSE
NC score	0.206164 (rank : 57)	θ value	0.21417 (rank : 175)
Query Neighborhood Hits	531	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

WIRE_HUMAN
NC score	0.205508 (rank : 58)	θ value	0.0193708 (rank : 93)
Query Neighborhood Hits	531	Target Neighborhood Hits	329	Shared Neighborhood Hits	102
SwissProt Accessions	Q8TF74, Q658J8, Q71RE1, Q8TE44	Gene names	WIRE, WICH
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein).

WIRE_MOUSE
NC score	0.201935 (rank : 59)	θ value	0.0193708 (rank : 94)
Query Neighborhood Hits	531	Target Neighborhood Hits	310	Shared Neighborhood Hits	100
SwissProt Accessions	Q6PEV3	Gene names	Wire
Domain Architecture	No domain graphic available
Description	WIP-related protein (WASP-interacting protein-related protein).

P55G_HUMAN
NC score	0.201727 (rank : 60)	θ value	0.62314 (rank : 252)
Query Neighborhood Hits	531	Target Neighborhood Hits	451	Shared Neighborhood Hits	72
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SH21A_MOUSE
NC score	0.201349 (rank : 61)	θ value	1.38821 (rank : 307)
Query Neighborhood Hits	531	Target Neighborhood Hits	89	Shared Neighborhood Hits	53
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

P85B_MOUSE
NC score	0.200696 (rank : 62)	θ value	0.279714 (rank : 197)
Query Neighborhood Hits	531	Target Neighborhood Hits	519	Shared Neighborhood Hits	83
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

MBD6_HUMAN
NC score	0.200504 (rank : 63)	θ value	0.000121331 (rank : 21)
Query Neighborhood Hits	531	Target Neighborhood Hits	349	Shared Neighborhood Hits	96
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

P55G_MOUSE
NC score	0.200018 (rank : 64)	θ value	0.62314 (rank : 253)
Query Neighborhood Hits	531	Target Neighborhood Hits	401	Shared Neighborhood Hits	69
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PRB4S_HUMAN
NC score	0.199117 (rank : 65)	θ value	0.000461057 (rank : 32)
Query Neighborhood Hits	531	Target Neighborhood Hits	330	Shared Neighborhood Hits	90
SwissProt Accessions	P10163, P02813	Gene names	PRB4
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 4 allele S precursor (Salivary proline-rich protein Po) (Parotid o protein) [Contains: Protein N1; Glycosylated protein A].

PRP1_HUMAN
NC score	0.198249 (rank : 66)	θ value	0.00020696 (rank : 26)
Query Neighborhood Hits	531	Target Neighborhood Hits	385	Shared Neighborhood Hits	102
SwissProt Accessions	P04280, Q08805, Q15186, Q15187, Q15214, Q15215, Q16038	Gene names	PRB1
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 1 precursor (Salivary proline-rich protein) [Contains: Basic peptide IB-6; Peptide P-H].

CRK_HUMAN
NC score	0.197248 (rank : 67)	θ value	1.38821 (rank : 296)
Query Neighborhood Hits	531	Target Neighborhood Hits	308	Shared Neighborhood Hits	87
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

BAT2_MOUSE
NC score	0.196554 (rank : 68)	θ value	0.365318 (rank : 213)
Query Neighborhood Hits	531	Target Neighborhood Hits	947	Shared Neighborhood Hits	230
SwissProt Accessions	Q7TSC1, Q923A9, Q9Z1R1	Gene names	Bat2
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

SH21A_HUMAN
NC score	0.195777 (rank : 69)	θ value	3.0926 (rank : 381)
Query Neighborhood Hits	531	Target Neighborhood Hits	89	Shared Neighborhood Hits	54
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

CRK_MOUSE
NC score	0.195672 (rank : 70)	θ value	1.38821 (rank : 297)
Query Neighborhood Hits	531	Target Neighborhood Hits	314	Shared Neighborhood Hits	90
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

WASL_HUMAN
NC score	0.194896 (rank : 71)	θ value	0.0148317 (rank : 87)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	102
SwissProt Accessions	O00401, Q7Z746	Gene names	WASL
Domain Architecture
Description	Neural Wiskott-Aldrich syndrome protein (N-WASP).

ATN1_HUMAN
NC score	0.194008 (rank : 72)	θ value	0.00869519 (rank : 65)
Query Neighborhood Hits	531	Target Neighborhood Hits	676	Shared Neighborhood Hits	131
SwissProt Accessions	P54259, Q99495, Q99621, Q9UEK7	Gene names	ATN1, DRPLA
Domain Architecture
Description	Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein).

BSN_MOUSE
NC score	0.192835 (rank : 73)	θ value	θ > 10 (rank : 588)
Query Neighborhood Hits	531	Target Neighborhood Hits	2057	Shared Neighborhood Hits	324
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

CRKL_HUMAN
NC score	0.192749 (rank : 74)	θ value	0.62314 (rank : 239)
Query Neighborhood Hits	531	Target Neighborhood Hits	313	Shared Neighborhood Hits	87
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

RAPH1_HUMAN
NC score	0.192219 (rank : 75)	θ value	0.00102713 (rank : 38)
Query Neighborhood Hits	531	Target Neighborhood Hits	593	Shared Neighborhood Hits	159
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SRRM2_MOUSE
NC score	0.191426 (rank : 76)	θ value	0.0563607 (rank : 124)
Query Neighborhood Hits	531	Target Neighborhood Hits	1470	Shared Neighborhood Hits	221
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ARI1A_HUMAN
NC score	0.190495 (rank : 77)	θ value	0.125558 (rank : 147)
Query Neighborhood Hits	531	Target Neighborhood Hits	787	Shared Neighborhood Hits	178
SwissProt Accessions	O14497, Q53FK9, Q5T0W1, Q5T0W2, Q5T0W3, Q8NFD6, Q96T89, Q9BY33, Q9HBJ5, Q9UPZ1	Gene names	ARID1A, C1orf4, OSA1, SMARCF1
Domain Architecture
Description	AT-rich interactive domain-containing protein 1A (ARID domain- containing protein 1A) (SWI/SNF-related, matrix-associated, actin- dependent regulator of chromatin subfamily F member 1) (SWI-SNF complex protein p270) (B120) (SWI-like protein) (Osa homolog 1) (hOSA1) (hELD) (BRG1-associated factor 250) (BAF250) (BRG1-associated factor 250a) (BAF250A).

P85A_MOUSE
NC score	0.189083 (rank : 78)	θ value	0.62314 (rank : 254)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	81
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SLAP2_MOUSE
NC score	0.188047 (rank : 79)	θ value	θ > 10 (rank : 956)
Query Neighborhood Hits	531	Target Neighborhood Hits	136	Shared Neighborhood Hits	66
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

P85A_HUMAN
NC score	0.185811 (rank : 80)	θ value	0.163984 (rank : 166)
Query Neighborhood Hits	531	Target Neighborhood Hits	479	Shared Neighborhood Hits	81
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

GRAP2_HUMAN
NC score	0.183999 (rank : 81)	θ value	θ > 10 (rank : 726)
Query Neighborhood Hits	531	Target Neighborhood Hits	304	Shared Neighborhood Hits	81
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SLAP2_HUMAN
NC score	0.183644 (rank : 82)	θ value	θ > 10 (rank : 955)
Query Neighborhood Hits	531	Target Neighborhood Hits	139	Shared Neighborhood Hits	68
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

PCLO_MOUSE
NC score	0.183440 (rank : 83)	θ value	0.365318 (rank : 219)
Query Neighborhood Hits	531	Target Neighborhood Hits	2275	Shared Neighborhood Hits	324
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

BAG3_MOUSE
NC score	0.182441 (rank : 84)	θ value	0.47712 (rank : 229)
Query Neighborhood Hits	531	Target Neighborhood Hits	513	Shared Neighborhood Hits	184
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BAT2_HUMAN
NC score	0.182307 (rank : 85)	θ value	8.99809 (rank : 504)
Query Neighborhood Hits	531	Target Neighborhood Hits	931	Shared Neighborhood Hits	226
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

RERE_MOUSE
NC score	0.181486 (rank : 86)	θ value	0.000786445 (rank : 36)
Query Neighborhood Hits	531	Target Neighborhood Hits	785	Shared Neighborhood Hits	173
SwissProt Accessions	Q80TZ9	Gene names	Rere, Atr2, Kiaa0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-2).

PRR12_HUMAN
NC score	0.181296 (rank : 87)	θ value	0.0563607 (rank : 123)
Query Neighborhood Hits	531	Target Neighborhood Hits	460	Shared Neighborhood Hits	117
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

WASF2_MOUSE
NC score	0.181050 (rank : 88)	θ value	0.00665767 (rank : 64)
Query Neighborhood Hits	531	Target Neighborhood Hits	315	Shared Neighborhood Hits	104
SwissProt Accessions	Q8BH43	Gene names	Wasf2, Wave2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2).

CO039_MOUSE
NC score	0.179757 (rank : 89)	θ value	0.163984 (rank : 160)
Query Neighborhood Hits	531	Target Neighborhood Hits	445	Shared Neighborhood Hits	162
SwissProt Accessions	Q3TEI4, Q3TMF2, Q3U253, Q3UM75, Q9DA93	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39 homolog.

GRAP2_MOUSE
NC score	0.179707 (rank : 90)	θ value	θ > 10 (rank : 727)
Query Neighborhood Hits	531	Target Neighborhood Hits	297	Shared Neighborhood Hits	80
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SPR1B_MOUSE
NC score	0.179493 (rank : 91)	θ value	θ > 10 (rank : 976)
Query Neighborhood Hits	531	Target Neighborhood Hits	395	Shared Neighborhood Hits	155
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

GRB14_MOUSE
NC score	0.179391 (rank : 92)	θ value	0.279714 (rank : 195)
Query Neighborhood Hits	531	Target Neighborhood Hits	149	Shared Neighborhood Hits	69
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

SC24C_HUMAN
NC score	0.177988 (rank : 93)	θ value	θ > 10 (rank : 923)
Query Neighborhood Hits	531	Target Neighborhood Hits	662	Shared Neighborhood Hits	181
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

WASF4_HUMAN
NC score	0.177694 (rank : 94)	θ value	0.0431538 (rank : 117)
Query Neighborhood Hits	531	Target Neighborhood Hits	282	Shared Neighborhood Hits	100
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

MLL4_HUMAN
NC score	0.177484 (rank : 95)	θ value	0.0148317 (rank : 82)
Query Neighborhood Hits	531	Target Neighborhood Hits	722	Shared Neighborhood Hits	159
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

ZIM10_HUMAN
NC score	0.177454 (rank : 96)	θ value	0.00869519 (rank : 72)
Query Neighborhood Hits	531	Target Neighborhood Hits	577	Shared Neighborhood Hits	181
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

WASP_HUMAN
NC score	0.175736 (rank : 97)	θ value	0.00298849 (rank : 56)
Query Neighborhood Hits	531	Target Neighborhood Hits	195	Shared Neighborhood Hits	74
SwissProt Accessions	P42768, Q9BU11, Q9UNJ9	Gene names	WAS, IMD2
Domain Architecture
Description	Wiskott-Aldrich syndrome protein (WASp).

MLL2_HUMAN
NC score	0.175639 (rank : 98)	θ value	0.00298849 (rank : 54)
Query Neighborhood Hits	531	Target Neighborhood Hits	1788	Shared Neighborhood Hits	255
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

SLAP1_MOUSE
NC score	0.175595 (rank : 99)	θ value	θ > 10 (rank : 954)
Query Neighborhood Hits	531	Target Neighborhood Hits	117	Shared Neighborhood Hits	61
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

CBP_MOUSE
NC score	0.175408 (rank : 100)	θ value	1.81305 (rank : 316)
Query Neighborhood Hits	531	Target Neighborhood Hits	1051	Shared Neighborhood Hits	216
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

IASPP_MOUSE
NC score	0.174176 (rank : 101)	θ value	θ > 10 (rank : 743)
Query Neighborhood Hits	531	Target Neighborhood Hits	1024	Shared Neighborhood Hits	230
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

RERE_HUMAN
NC score	0.173902 (rank : 102)	θ value	0.00665767 (rank : 62)
Query Neighborhood Hits	531	Target Neighborhood Hits	779	Shared Neighborhood Hits	166
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

SLAP1_HUMAN
NC score	0.173877 (rank : 103)	θ value	θ > 10 (rank : 953)
Query Neighborhood Hits	531	Target Neighborhood Hits	113	Shared Neighborhood Hits	62
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

PRG4_HUMAN
NC score	0.173639 (rank : 104)	θ value	2.44474e-05 (rank : 11)
Query Neighborhood Hits	531	Target Neighborhood Hits	764	Shared Neighborhood Hits	137
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

WBP11_HUMAN
NC score	0.173219 (rank : 105)	θ value	0.0563607 (rank : 125)
Query Neighborhood Hits	531	Target Neighborhood Hits	354	Shared Neighborhood Hits	93
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WASF1_HUMAN
NC score	0.172634 (rank : 106)	θ value	0.00298849 (rank : 55)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	80
SwissProt Accessions	Q92558	Gene names	WASF1, KIAA0269, SCAR1, WAVE1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1).

WBP11_MOUSE
NC score	0.172542 (rank : 107)	θ value	0.0563607 (rank : 126)
Query Neighborhood Hits	531	Target Neighborhood Hits	362	Shared Neighborhood Hits	91
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

SRRM2_HUMAN
NC score	0.172088 (rank : 108)	θ value	0.00869519 (rank : 70)
Query Neighborhood Hits	531	Target Neighborhood Hits	1296	Shared Neighborhood Hits	196
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

WASF1_MOUSE
NC score	0.171942 (rank : 109)	θ value	0.00228821 (rank : 52)
Query Neighborhood Hits	531	Target Neighborhood Hits	261	Shared Neighborhood Hits	78
SwissProt Accessions	Q8R5H6, Q91W51, Q9ERQ9	Gene names	Wasf1, Wave1
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 1 (WASP-family protein member 1) (Protein WAVE-1).

SOCS2_MOUSE
NC score	0.170680 (rank : 110)	θ value	0.279714 (rank : 208)
Query Neighborhood Hits	531	Target Neighborhood Hits	94	Shared Neighborhood Hits	55
SwissProt Accessions	O35717	Gene names	Socs2, Cis2, Cish2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2).

CN032_HUMAN
NC score	0.169638 (rank : 111)	θ value	0.0252991 (rank : 98)
Query Neighborhood Hits	531	Target Neighborhood Hits	267	Shared Neighborhood Hits	74
SwissProt Accessions	Q8NDC0, Q96BG5	Gene names	C14orf32
Domain Architecture	No domain graphic available
Description	Protein C14orf32.

T22D4_HUMAN
NC score	0.169249 (rank : 112)	θ value	0.21417 (rank : 185)
Query Neighborhood Hits	531	Target Neighborhood Hits	403	Shared Neighborhood Hits	126
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

SOCS2_HUMAN
NC score	0.169095 (rank : 113)	θ value	0.279714 (rank : 207)
Query Neighborhood Hits	531	Target Neighborhood Hits	104	Shared Neighborhood Hits	55
SwissProt Accessions	O14508, O14542, O95102, Q9UKS5	Gene names	SOCS2, CIS2, SSI2, STATI2
Domain Architecture
Description	Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2).

PTN11_MOUSE
NC score	0.168115 (rank : 114)	θ value	0.00228821 (rank : 50)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.168094 (rank : 115)	θ value	0.00228821 (rank : 49)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	78
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

SNPC4_HUMAN
NC score	0.167597 (rank : 116)	θ value	0.163984 (rank : 169)
Query Neighborhood Hits	531	Target Neighborhood Hits	589	Shared Neighborhood Hits	162
SwissProt Accessions	Q5SXM2, Q9Y6P7	Gene names	SNAPC4, SNAP190
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit) (Proximal sequence element-binding transcription factor subunit alpha) (PSE-binding factor subunit alpha) (PTF subunit alpha).

SSBP4_HUMAN
NC score	0.167508 (rank : 117)	θ value	θ > 10 (rank : 987)
Query Neighborhood Hits	531	Target Neighborhood Hits	753	Shared Neighborhood Hits	194
SwissProt Accessions	Q9BWG4	Gene names	SSBP4
Domain Architecture
Description	Single-stranded DNA-binding protein 4.

TARA_HUMAN
NC score	0.166297 (rank : 118)	θ value	0.0736092 (rank : 137)
Query Neighborhood Hits	531	Target Neighborhood Hits	1626	Shared Neighborhood Hits	245
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

EP300_HUMAN
NC score	0.165990 (rank : 119)	θ value	0.00175202 (rank : 41)
Query Neighborhood Hits	531	Target Neighborhood Hits	821	Shared Neighborhood Hits	181
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

PI5PA_HUMAN
NC score	0.164639 (rank : 120)	θ value	0.279714 (rank : 201)
Query Neighborhood Hits	531	Target Neighborhood Hits	749	Shared Neighborhood Hits	209
SwissProt Accessions	Q15735, Q32M61, Q6ZTH6, Q8N902, Q9UDT9	Gene names	PIB5PA, PIPP
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

WASF2_HUMAN
NC score	0.164604 (rank : 121)	θ value	0.125558 (rank : 158)
Query Neighborhood Hits	531	Target Neighborhood Hits	280	Shared Neighborhood Hits	95
SwissProt Accessions	Q9Y6W5, O60794, Q9UDY7	Gene names	WASF2, WAVE2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 2 (WASP-family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2).

GRB14_HUMAN
NC score	0.164579 (rank : 122)	θ value	4.03905 (rank : 401)
Query Neighborhood Hits	531	Target Neighborhood Hits	137	Shared Neighborhood Hits	65
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

PRP2_MOUSE
NC score	0.164479 (rank : 123)	θ value	1.81305 (rank : 330)
Query Neighborhood Hits	531	Target Neighborhood Hits	347	Shared Neighborhood Hits	94
SwissProt Accessions	P05142	Gene names	Prh1, Prp
Domain Architecture	No domain graphic available
Description	Proline-rich protein MP-2 precursor.

LAD1_HUMAN
NC score	0.162841 (rank : 124)	θ value	0.0252991 (rank : 101)
Query Neighborhood Hits	531	Target Neighborhood Hits	441	Shared Neighborhood Hits	111
SwissProt Accessions	O00515, O95614	Gene names	LAD1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (120 kDa linear IgA bullous dermatosis antigen) (97 kDa linear IgA bullous dermatosis antigen) (Linear IgA disease antigen homolog) (LadA).

LPP_HUMAN
NC score	0.162641 (rank : 125)	θ value	θ > 10 (rank : 792)
Query Neighborhood Hits	531	Target Neighborhood Hits	775	Shared Neighborhood Hits	207
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

SHE_HUMAN
NC score	0.161473 (rank : 126)	θ value	θ > 10 (rank : 951)
Query Neighborhood Hits	531	Target Neighborhood Hits	164	Shared Neighborhood Hits	79
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

BCAR1_HUMAN
NC score	0.161428 (rank : 127)	θ value	2.36792 (rank : 337)
Query Neighborhood Hits	531	Target Neighborhood Hits	554	Shared Neighborhood Hits	184
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

YLPM1_HUMAN
NC score	0.160832 (rank : 128)	θ value	0.62314 (rank : 258)
Query Neighborhood Hits	531	Target Neighborhood Hits	670	Shared Neighborhood Hits	152
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

ASPP1_MOUSE
NC score	0.160638 (rank : 129)	θ value	0.62314 (rank : 237)
Query Neighborhood Hits	531	Target Neighborhood Hits	1244	Shared Neighborhood Hits	221
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ZIMP7_MOUSE
NC score	0.159904 (rank : 130)	θ value	θ > 10 (rank : 1060)
Query Neighborhood Hits	531	Target Neighborhood Hits	566	Shared Neighborhood Hits	158
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

DIDO1_HUMAN
NC score	0.159732 (rank : 131)	θ value	θ > 10 (rank : 643)
Query Neighborhood Hits	531	Target Neighborhood Hits	960	Shared Neighborhood Hits	201
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

MKL1_MOUSE
NC score	0.159372 (rank : 132)	θ value	0.0113563 (rank : 76)
Query Neighborhood Hits	531	Target Neighborhood Hits	667	Shared Neighborhood Hits	174
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

SHE_MOUSE
NC score	0.159225 (rank : 133)	θ value	θ > 10 (rank : 952)
Query Neighborhood Hits	531	Target Neighborhood Hits	169	Shared Neighborhood Hits	79
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

IWS1_MOUSE
NC score	0.158124 (rank : 134)	θ value	0.163984 (rank : 162)
Query Neighborhood Hits	531	Target Neighborhood Hits	1258	Shared Neighborhood Hits	179
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SAPS1_HUMAN
NC score	0.157104 (rank : 135)	θ value	θ > 10 (rank : 921)
Query Neighborhood Hits	531	Target Neighborhood Hits	704	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

SELPL_MOUSE
NC score	0.155835 (rank : 136)	θ value	θ > 10 (rank : 924)
Query Neighborhood Hits	531	Target Neighborhood Hits	588	Shared Neighborhood Hits	158
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SOCS7_MOUSE
NC score	0.155014 (rank : 137)	θ value	1.38821 (rank : 310)
Query Neighborhood Hits	531	Target Neighborhood Hits	154	Shared Neighborhood Hits	66
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

TCGAP_HUMAN
NC score	0.154656 (rank : 138)	θ value	θ > 10 (rank : 1010)
Query Neighborhood Hits	531	Target Neighborhood Hits	872	Shared Neighborhood Hits	216
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

PRG4_MOUSE
NC score	0.154587 (rank : 139)	θ value	0.00175202 (rank : 43)
Query Neighborhood Hits	531	Target Neighborhood Hits	624	Shared Neighborhood Hits	115
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

CJ078_MOUSE
NC score	0.153629 (rank : 140)	θ value	0.0736092 (rank : 128)
Query Neighborhood Hits	531	Target Neighborhood Hits	559	Shared Neighborhood Hits	115
SwissProt Accessions	Q8BP27, Q3UIQ6, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4	Gene names
Domain Architecture	No domain graphic available
Description	Protein C10orf78 homolog.

ALEX_HUMAN
NC score	0.153584 (rank : 141)	θ value	2.36792 (rank : 333)
Query Neighborhood Hits	531	Target Neighborhood Hits	361	Shared Neighborhood Hits	107
SwissProt Accessions	P84996	Gene names	GNAS, GNAS1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

GGN_HUMAN
NC score	0.153290 (rank : 142)	θ value	0.0113563 (rank : 75)
Query Neighborhood Hits	531	Target Neighborhood Hits	269	Shared Neighborhood Hits	80
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

PRB3_HUMAN
NC score	0.152701 (rank : 143)	θ value	0.365318 (rank : 220)
Query Neighborhood Hits	531	Target Neighborhood Hits	318	Shared Neighborhood Hits	87
SwissProt Accessions	Q04118, Q15188, Q7M4M9	Gene names	PRB3
Domain Architecture	No domain graphic available
Description	Basic salivary proline-rich protein 3 precursor (Parotid salivary glycoprotein G1) (Proline-rich protein G1).

TGON2_HUMAN
NC score	0.151835 (rank : 144)	θ value	6.88961 (rank : 495)
Query Neighborhood Hits	531	Target Neighborhood Hits	1037	Shared Neighborhood Hits	164
SwissProt Accessions	O43493, O15282, O43492, O43499, O43500, O43501, Q92760	Gene names	TGOLN2, TGN46, TGN51
Domain Architecture
Description	Trans-Golgi network integral membrane protein 2 precursor (Trans-Golgi network protein TGN51) (TGN46) (TGN48) (TGN38 homolog).

GSCR1_HUMAN
NC score	0.151707 (rank : 145)	θ value	2.36792 (rank : 344)
Query Neighborhood Hits	531	Target Neighborhood Hits	674	Shared Neighborhood Hits	167
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

CBP_HUMAN
NC score	0.150690 (rank : 146)	θ value	5.27518 (rank : 430)
Query Neighborhood Hits	531	Target Neighborhood Hits	941	Shared Neighborhood Hits	196
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

SOCS6_MOUSE
NC score	0.150437 (rank : 147)	θ value	0.813845 (rank : 273)
Query Neighborhood Hits	531	Target Neighborhood Hits	146	Shared Neighborhood Hits	62
SwissProt Accessions	Q9JLY0, Q9D2A0	Gene names	Socs6, Cis4, Cish4, Socs4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

YLPM1_MOUSE
NC score	0.150324 (rank : 148)	θ value	0.279714 (rank : 211)
Query Neighborhood Hits	531	Target Neighborhood Hits	505	Shared Neighborhood Hits	115
SwissProt Accessions	Q9R0I7, Q7TMM4	Gene names	Ylpm1, Zap, Zap3
Domain Architecture	No domain graphic available
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3).

SET1A_HUMAN
NC score	0.150188 (rank : 149)	θ value	5.27518 (rank : 450)
Query Neighborhood Hits	531	Target Neighborhood Hits	690	Shared Neighborhood Hits	128
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

WASP_MOUSE
NC score	0.149425 (rank : 150)	θ value	3.0926 (rank : 386)
Query Neighborhood Hits	531	Target Neighborhood Hits	223	Shared Neighborhood Hits	78
SwissProt Accessions	P70315	Gene names	Was, Wasp
Domain Architecture
Description	Wiskott-Aldrich syndrome protein homolog (WASp).

GGN_MOUSE
NC score	0.148419 (rank : 151)	θ value	0.365318 (rank : 216)
Query Neighborhood Hits	531	Target Neighborhood Hits	311	Shared Neighborhood Hits	88
SwissProt Accessions	Q80WJ1, Q5EBP4, Q80WI9, Q80WJ0	Gene names	Ggn
Domain Architecture	No domain graphic available
Description	Gametogenetin.

CPSF6_MOUSE
NC score	0.148298 (rank : 152)	θ value	0.0563607 (rank : 120)
Query Neighborhood Hits	531	Target Neighborhood Hits	356	Shared Neighborhood Hits	93
SwissProt Accessions	Q6NVF9, Q8BX86, Q8BXI8	Gene names	Cpsf6
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6.

CISH_MOUSE
NC score	0.147685 (rank : 153)	θ value	0.125558 (rank : 148)
Query Neighborhood Hits	531	Target Neighborhood Hits	94	Shared Neighborhood Hits	49
SwissProt Accessions	Q62225, Q3TC70	Gene names	Cish, Cis
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS).

CIC_HUMAN
NC score	0.147467 (rank : 154)	θ value	θ > 10 (rank : 602)
Query Neighborhood Hits	531	Target Neighborhood Hits	992	Shared Neighborhood Hits	216
SwissProt Accessions	Q96RK0, Q7LGI1, Q9UEG5, Q9Y6T1	Gene names	CIC, KIAA0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

TXND2_HUMAN
NC score	0.147432 (rank : 155)	θ value	θ > 10 (rank : 1029)
Query Neighborhood Hits	531	Target Neighborhood Hits	793	Shared Neighborhood Hits	163
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

PSL1_HUMAN
NC score	0.147337 (rank : 156)	θ value	θ > 10 (rank : 894)
Query Neighborhood Hits	531	Target Neighborhood Hits	650	Shared Neighborhood Hits	204
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

CPSF6_HUMAN
NC score	0.146882 (rank : 157)	θ value	0.0563607 (rank : 119)
Query Neighborhood Hits	531	Target Neighborhood Hits	359	Shared Neighborhood Hits	93
SwissProt Accessions	Q16630, Q53ES1, Q9BSJ7, Q9BW18	Gene names	CPSF6, CFIM68
Domain Architecture	No domain graphic available
Description	Cleavage and polyadenylation specificity factor 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII- 4/7).

SOCS6_HUMAN
NC score	0.146223 (rank : 158)	θ value	0.813845 (rank : 272)
Query Neighborhood Hits	531	Target Neighborhood Hits	126	Shared Neighborhood Hits	53
SwissProt Accessions	O14544	Gene names	SOCS6, CIS4, SOCS4
Domain Architecture
Description	Suppressor of cytokine signaling 6 (SOCS-6) (Suppressor of cytokine signaling 4) (SOCS-4) (Cytokine-inducible SH2 protein 4) (CIS-4).

GRB7_MOUSE
NC score	0.146207 (rank : 159)	θ value	θ > 10 (rank : 731)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	73
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

K1802_HUMAN
NC score	0.146181 (rank : 160)	θ value	0.00509761 (rank : 60)
Query Neighborhood Hits	531	Target Neighborhood Hits	1378	Shared Neighborhood Hits	222
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

VAV3_MOUSE
NC score	0.146066 (rank : 161)	θ value	6.88961 (rank : 497)
Query Neighborhood Hits	531	Target Neighborhood Hits	404	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

3BP2_HUMAN
NC score	0.145629 (rank : 162)	θ value	0.0193708 (rank : 88)
Query Neighborhood Hits	531	Target Neighborhood Hits	296	Shared Neighborhood Hits	108
SwissProt Accessions	P78314, O00500, O15373, P78315	Gene names	SH3BP2, 3BP2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CISH_HUMAN
NC score	0.145543 (rank : 163)	θ value	0.21417 (rank : 174)
Query Neighborhood Hits	531	Target Neighborhood Hits	94	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NSE2, Q9NS38, Q9Y5R1	Gene names	CISH, G18
Domain Architecture
Description	Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS) (Protein G18).

VAV3_HUMAN
NC score	0.145192 (rank : 164)	θ value	θ > 10 (rank : 1041)
Query Neighborhood Hits	531	Target Neighborhood Hits	398	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SON_MOUSE
NC score	0.145134 (rank : 165)	θ value	θ > 10 (rank : 968)
Query Neighborhood Hits	531	Target Neighborhood Hits	957	Shared Neighborhood Hits	196
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

NFH_MOUSE
NC score	0.144940 (rank : 166)	θ value	θ > 10 (rank : 835)
Query Neighborhood Hits	531	Target Neighborhood Hits	2247	Shared Neighborhood Hits	286
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

ZIM10_MOUSE
NC score	0.144680 (rank : 167)	θ value	0.00175202 (rank : 46)
Query Neighborhood Hits	531	Target Neighborhood Hits	430	Shared Neighborhood Hits	125
SwissProt Accessions	Q6P1E1, Q6PDK9, Q6PF85, Q8BW47	Gene names	Rai17, Zimp10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

HRX_HUMAN
NC score	0.144510 (rank : 168)	θ value	0.00298849 (rank : 53)
Query Neighborhood Hits	531	Target Neighborhood Hits	825	Shared Neighborhood Hits	133
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

IWS1_HUMAN
NC score	0.144495 (rank : 169)	θ value	0.0330416 (rank : 108)
Query Neighborhood Hits	531	Target Neighborhood Hits	1241	Shared Neighborhood Hits	163
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

SF3A2_HUMAN
NC score	0.144133 (rank : 170)	θ value	0.0736092 (rank : 133)
Query Neighborhood Hits	531	Target Neighborhood Hits	263	Shared Neighborhood Hits	80
SwissProt Accessions	Q15428, O75245	Gene names	SF3A2, SAP62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

CECR2_HUMAN
NC score	0.144107 (rank : 171)	θ value	3.0926 (rank : 365)
Query Neighborhood Hits	531	Target Neighborhood Hits	543	Shared Neighborhood Hits	145
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

GRB7_HUMAN
NC score	0.143314 (rank : 172)	θ value	θ > 10 (rank : 730)
Query Neighborhood Hits	531	Target Neighborhood Hits	156	Shared Neighborhood Hits	70
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

SPR1A_MOUSE
NC score	0.143235 (rank : 173)	θ value	θ > 10 (rank : 975)
Query Neighborhood Hits	531	Target Neighborhood Hits	343	Shared Neighborhood Hits	139
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

ATX7_HUMAN
NC score	0.143133 (rank : 174)	θ value	0.62314 (rank : 238)
Query Neighborhood Hits	531	Target Neighborhood Hits	351	Shared Neighborhood Hits	131
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

SF3A2_MOUSE
NC score	0.142987 (rank : 175)	θ value	0.365318 (rank : 223)
Query Neighborhood Hits	531	Target Neighborhood Hits	247	Shared Neighborhood Hits	81
SwissProt Accessions	Q62203	Gene names	Sf3a2, Sap62
Domain Architecture
Description	Splicing factor 3A subunit 2 (Spliceosome-associated protein 62) (SAP 62) (SF3a66).

RTP3_MOUSE
NC score	0.142858 (rank : 176)	θ value	θ > 10 (rank : 917)
Query Neighborhood Hits	531	Target Neighborhood Hits	374	Shared Neighborhood Hits	126
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

APS_HUMAN
NC score	0.141913 (rank : 177)	θ value	θ > 10 (rank : 560)
Query Neighborhood Hits	531	Target Neighborhood Hits	162	Shared Neighborhood Hits	64
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

SFPQ_MOUSE
NC score	0.140796 (rank : 178)	θ value	0.00175202 (rank : 44)
Query Neighborhood Hits	531	Target Neighborhood Hits	958	Shared Neighborhood Hits	119
SwissProt Accessions	Q8VIJ6, Q9ERW2	Gene names	Sfpq
Domain Architecture	No domain graphic available
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit).

FMN1A_MOUSE
NC score	0.140571 (rank : 179)	θ value	0.0148317 (rank : 80)
Query Neighborhood Hits	531	Target Neighborhood Hits	423	Shared Neighborhood Hits	101
SwissProt Accessions	Q05860	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoforms I/II/III (Limb deformity protein).

PS1C2_HUMAN
NC score	0.139130 (rank : 180)	θ value	0.0736092 (rank : 132)
Query Neighborhood Hits	531	Target Neighborhood Hits	66	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UIG4	Gene names	PSORS1C2, C6orf17, SPR1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein precursor (SPR1 protein).

CN032_MOUSE
NC score	0.139000 (rank : 181)	θ value	θ > 10 (rank : 608)
Query Neighborhood Hits	531	Target Neighborhood Hits	233	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BH93, Q3TF12, Q3TGL0, Q8CC90	Gene names
Domain Architecture	No domain graphic available
Description	Protein C14orf32 homolog.

MILK1_MOUSE
NC score	0.138368 (rank : 182)	θ value	0.0736092 (rank : 130)
Query Neighborhood Hits	531	Target Neighborhood Hits	788	Shared Neighborhood Hits	188
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

SC24A_MOUSE
NC score	0.138337 (rank : 183)	θ value	0.279714 (rank : 204)
Query Neighborhood Hits	531	Target Neighborhood Hits	394	Shared Neighborhood Hits	152
SwissProt Accessions	Q3U2P1, Q3TQ05, Q3TRG7, Q8BIS0	Gene names	Sec24a
Domain Architecture	No domain graphic available
Description	Protein transport protein Sec24A (SEC24-related protein A).

LAD1_MOUSE
NC score	0.138010 (rank : 184)	θ value	θ > 10 (rank : 782)
Query Neighborhood Hits	531	Target Neighborhood Hits	391	Shared Neighborhood Hits	96
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

ENAH_MOUSE
NC score	0.137689 (rank : 185)	θ value	0.00134147 (rank : 39)
Query Neighborhood Hits	531	Target Neighborhood Hits	919	Shared Neighborhood Hits	140
SwissProt Accessions	Q03173, P70430, P70431, P70432, P70433, Q5D053	Gene names	Enah, Mena, Ndpp1
Domain Architecture
Description	Protein enabled homolog (NPC-derived proline-rich protein 1) (NDPP-1).

PTN6_MOUSE
NC score	0.137449 (rank : 186)	θ value	0.0252991 (rank : 102)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	78
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

SHB_MOUSE
NC score	0.137322 (rank : 187)	θ value	θ > 10 (rank : 949)
Query Neighborhood Hits	531	Target Neighborhood Hits	137	Shared Neighborhood Hits	69
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

GRB10_MOUSE
NC score	0.137251 (rank : 188)	θ value	θ > 10 (rank : 729)
Query Neighborhood Hits	531	Target Neighborhood Hits	156	Shared Neighborhood Hits	65
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB10_HUMAN
NC score	0.137168 (rank : 189)	θ value	θ > 10 (rank : 728)
Query Neighborhood Hits	531	Target Neighborhood Hits	147	Shared Neighborhood Hits	66
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

WASF3_HUMAN
NC score	0.137167 (rank : 190)	θ value	6.88961 (rank : 498)
Query Neighborhood Hits	531	Target Neighborhood Hits	204	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UPY6, O94974	Gene names	WASF3, KIAA0900, SCAR3, WAVE3
Domain Architecture
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3).

SFPQ_HUMAN
NC score	0.137104 (rank : 191)	θ value	0.000270298 (rank : 28)
Query Neighborhood Hits	531	Target Neighborhood Hits	986	Shared Neighborhood Hits	125
SwissProt Accessions	P23246, P30808	Gene names	SFPQ, PSF
Domain Architecture
Description	Splicing factor, proline- and glutamine-rich (Polypyrimidine tract- binding protein-associated-splicing factor) (PTB-associated-splicing factor) (PSF) (DNA-binding p52/p100 complex, 100 kDa subunit) (100 kDa DNA-pairing protein) (hPOMp100).

VAV_HUMAN
NC score	0.136687 (rank : 192)	θ value	θ > 10 (rank : 1042)
Query Neighborhood Hits	531	Target Neighborhood Hits	452	Shared Neighborhood Hits	87
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

CCNK_MOUSE
NC score	0.136027 (rank : 193)	θ value	0.0113563 (rank : 74)
Query Neighborhood Hits	531	Target Neighborhood Hits	350	Shared Neighborhood Hits	100
SwissProt Accessions	O88874, Q8R068	Gene names	Ccnk
Domain Architecture	No domain graphic available
Description	Cyclin-K.

SHB_HUMAN
NC score	0.135965 (rank : 194)	θ value	θ > 10 (rank : 948)
Query Neighborhood Hits	531	Target Neighborhood Hits	141	Shared Neighborhood Hits	69
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHD_HUMAN
NC score	0.135314 (rank : 195)	θ value	5.27518 (rank : 452)
Query Neighborhood Hits	531	Target Neighborhood Hits	204	Shared Neighborhood Hits	87
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

MUCDL_HUMAN
NC score	0.134735 (rank : 196)	θ value	θ > 10 (rank : 824)
Query Neighborhood Hits	531	Target Neighborhood Hits	777	Shared Neighborhood Hits	182
SwissProt Accessions	Q9HBB8, Q9H746, Q9HAU3, Q9HBB5, Q9HBB6, Q9HBB7, Q9NX86, Q9NXI9	Gene names	MUCDHL
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

FMNL_HUMAN
NC score	0.134606 (rank : 197)	θ value	0.00665767 (rank : 61)
Query Neighborhood Hits	531	Target Neighborhood Hits	529	Shared Neighborhood Hits	102
SwissProt Accessions	O95466, Q6DKG5, Q6IBP3, Q86UH1, Q8N671, Q8TDH1, Q96H10	Gene names	FMNL1, C17orf1, C17orf1B, FMNL
Domain Architecture
Description	Formin-like protein 1 (Leukocyte formin) (CLL-associated antigen KW- 13).

ZN645_HUMAN
NC score	0.134320 (rank : 198)	θ value	θ > 10 (rank : 1062)
Query Neighborhood Hits	531	Target Neighborhood Hits	265	Shared Neighborhood Hits	102
SwissProt Accessions	Q8N7E2, Q6DJY9	Gene names	ZNF645
Domain Architecture	No domain graphic available
Description	Zinc finger protein 645.

SPT5H_MOUSE
NC score	0.133889 (rank : 199)	θ value	θ > 10 (rank : 980)
Query Neighborhood Hits	531	Target Neighborhood Hits	437	Shared Neighborhood Hits	130
SwissProt Accessions	O55201, Q3UJ77, Q3UJH1, Q3UKD7, Q3UM54, Q6PB73, Q6PDP0, Q6PFR4	Gene names	Supt5h
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (DRB sensitivity-inducing factor large subunit) (DSIF large subunit).

SH24A_HUMAN
NC score	0.133449 (rank : 200)	θ value	θ > 10 (rank : 938)
Query Neighborhood Hits	531	Target Neighborhood Hits	455	Shared Neighborhood Hits	80
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

MINT_MOUSE
NC score	0.133241 (rank : 201)	θ value	θ > 10 (rank : 815)
Query Neighborhood Hits	531	Target Neighborhood Hits	1514	Shared Neighborhood Hits	244
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

SPT5H_HUMAN
NC score	0.133130 (rank : 202)	θ value	θ > 10 (rank : 979)
Query Neighborhood Hits	531	Target Neighborhood Hits	436	Shared Neighborhood Hits	131
SwissProt Accessions	O00267, O43279, Q59G52, Q99639	Gene names	SUPT5H, SPT5, SPT5H
Domain Architecture	No domain graphic available
Description	Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (DSIF p160) (Tat- cotransactivator 1 protein) (Tat-CT1 protein).

FMN1B_MOUSE
NC score	0.132431 (rank : 203)	θ value	0.0148317 (rank : 81)
Query Neighborhood Hits	531	Target Neighborhood Hits	447	Shared Neighborhood Hits	103
SwissProt Accessions	Q05859	Gene names	Fmn, Ld
Domain Architecture
Description	Formin-1 isoform IV (Limb deformity protein).

PTN6_HUMAN
NC score	0.131958 (rank : 204)	θ value	0.125558 (rank : 155)
Query Neighborhood Hits	531	Target Neighborhood Hits	234	Shared Neighborhood Hits	75
SwissProt Accessions	P29350, Q969V8	Gene names	PTPN6, HCP, PTP1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1).

MTSS1_MOUSE
NC score	0.131805 (rank : 205)	θ value	θ > 10 (rank : 819)
Query Neighborhood Hits	531	Target Neighborhood Hits	592	Shared Neighborhood Hits	159
SwissProt Accessions	Q8R1S4, Q8BMM3, Q99LB3	Gene names	Mtss1, Mim
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein).

VAV2_HUMAN
NC score	0.131669 (rank : 206)	θ value	θ > 10 (rank : 1039)
Query Neighborhood Hits	531	Target Neighborhood Hits	453	Shared Neighborhood Hits	93
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.131610 (rank : 207)	θ value	θ > 10 (rank : 1040)
Query Neighborhood Hits	531	Target Neighborhood Hits	456	Shared Neighborhood Hits	97
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

LNK_MOUSE
NC score	0.131111 (rank : 208)	θ value	θ > 10 (rank : 791)
Query Neighborhood Hits	531	Target Neighborhood Hits	132	Shared Neighborhood Hits	63
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

VAV_MOUSE
NC score	0.130427 (rank : 209)	θ value	θ > 10 (rank : 1043)
Query Neighborhood Hits	531	Target Neighborhood Hits	430	Shared Neighborhood Hits	85
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

K1543_MOUSE
NC score	0.130254 (rank : 210)	θ value	θ > 10 (rank : 773)
Query Neighborhood Hits	531	Target Neighborhood Hits	497	Shared Neighborhood Hits	143
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

PCQAP_HUMAN
NC score	0.128830 (rank : 211)	θ value	0.0148317 (rank : 83)
Query Neighborhood Hits	531	Target Neighborhood Hits	549	Shared Neighborhood Hits	78
SwissProt Accessions	Q96RN5, O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3	Gene names	PCQAP, ARC105, CTG7A, TIG1
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a).

GA2L2_MOUSE
NC score	0.128554 (rank : 212)	θ value	θ > 10 (rank : 719)
Query Neighborhood Hits	531	Target Neighborhood Hits	395	Shared Neighborhood Hits	150
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

LNK_HUMAN
NC score	0.128195 (rank : 213)	θ value	θ > 10 (rank : 790)
Query Neighborhood Hits	531	Target Neighborhood Hits	151	Shared Neighborhood Hits	66
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

ZN207_HUMAN
NC score	0.128114 (rank : 214)	θ value	0.21417 (rank : 189)
Query Neighborhood Hits	531	Target Neighborhood Hits	326	Shared Neighborhood Hits	56
SwissProt Accessions	O43670, Q96HW5, Q9BUQ7	Gene names	ZNF207
Domain Architecture	No domain graphic available
Description	Zinc finger protein 207.

AB1IP_HUMAN
NC score	0.128048 (rank : 215)	θ value	0.279714 (rank : 190)
Query Neighborhood Hits	531	Target Neighborhood Hits	213	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z5R6, Q8IWS8, Q8IZZ7	Gene names	APBB1IP, PREL1, RARP1, RIAM
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Rap1-GTP- interacting adapter molecule) (RIAM) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Retinoic acid-responsive proline- rich protein 1) (RARP-1).

FGR_MOUSE
NC score	0.127867 (rank : 216)	θ value	0.00509761 (rank : 59)
Query Neighborhood Hits	531	Target Neighborhood Hits	1069	Shared Neighborhood Hits	104
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ECM1_HUMAN
NC score	0.127706 (rank : 217)	θ value	0.365318 (rank : 214)
Query Neighborhood Hits	531	Target Neighborhood Hits	182	Shared Neighborhood Hits	76
SwissProt Accessions	Q16610	Gene names	ECM1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

SHD_MOUSE
NC score	0.127305 (rank : 218)	θ value	θ > 10 (rank : 950)
Query Neighborhood Hits	531	Target Neighborhood Hits	137	Shared Neighborhood Hits	69
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

BSN_HUMAN
NC score	0.127065 (rank : 219)	θ value	θ > 10 (rank : 587)
Query Neighborhood Hits	531	Target Neighborhood Hits	1537	Shared Neighborhood Hits	230
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

CK024_HUMAN
NC score	0.126772 (rank : 220)	θ value	θ > 10 (rank : 606)
Query Neighborhood Hits	531	Target Neighborhood Hits	408	Shared Neighborhood Hits	126
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

PRR8_HUMAN
NC score	0.126596 (rank : 221)	θ value	0.163984 (rank : 168)
Query Neighborhood Hits	531	Target Neighborhood Hits	217	Shared Neighborhood Hits	54
SwissProt Accessions	Q9NSV0	Gene names	PRR8
Domain Architecture	No domain graphic available
Description	Proline-rich protein 8.

AB1IP_MOUSE
NC score	0.126057 (rank : 222)	θ value	0.0113563 (rank : 73)
Query Neighborhood Hits	531	Target Neighborhood Hits	181	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5A3, O35329, Q8BRU0, Q99KV8	Gene names	Apbb1ip, Prel1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 1- interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 48).

SH22A_MOUSE
NC score	0.125545 (rank : 223)	θ value	θ > 10 (rank : 937)
Query Neighborhood Hits	531	Target Neighborhood Hits	179	Shared Neighborhood Hits	84
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

MAP1A_HUMAN
NC score	0.124914 (rank : 224)	θ value	0.813845 (rank : 263)
Query Neighborhood Hits	531	Target Neighborhood Hits	1626	Shared Neighborhood Hits	222
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

AFF1_HUMAN
NC score	0.124310 (rank : 225)	θ value	1.06291 (rank : 278)
Query Neighborhood Hits	531	Target Neighborhood Hits	506	Shared Neighborhood Hits	97
SwissProt Accessions	P51825	Gene names	AFF1, AF4, FEL, MLLT2
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4) (Protein FEL).

FGR_HUMAN
NC score	0.124138 (rank : 226)	θ value	0.00869519 (rank : 66)
Query Neighborhood Hits	531	Target Neighborhood Hits	1067	Shared Neighborhood Hits	104
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

TPO_MOUSE
NC score	0.123761 (rank : 227)	θ value	θ > 10 (rank : 1025)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	104
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

MUC7_HUMAN
NC score	0.123699 (rank : 228)	θ value	θ > 10 (rank : 823)
Query Neighborhood Hits	531	Target Neighborhood Hits	538	Shared Neighborhood Hits	113
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

BTK_HUMAN
NC score	0.123434 (rank : 229)	θ value	0.000158464 (rank : 22)
Query Neighborhood Hits	531	Target Neighborhood Hits	1026	Shared Neighborhood Hits	96
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SRC_MOUSE
NC score	0.123300 (rank : 230)	θ value	7.1131e-05 (rank : 18)
Query Neighborhood Hits	531	Target Neighborhood Hits	1033	Shared Neighborhood Hits	103
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRC_HUMAN
NC score	0.123154 (rank : 231)	θ value	7.1131e-05 (rank : 17)
Query Neighborhood Hits	531	Target Neighborhood Hits	1058	Shared Neighborhood Hits	103
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

BTK_MOUSE
NC score	0.122762 (rank : 232)	θ value	0.00035302 (rank : 29)
Query Neighborhood Hits	531	Target Neighborhood Hits	1017	Shared Neighborhood Hits	96
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

BCAR1_MOUSE
NC score	0.122598 (rank : 233)	θ value	θ > 10 (rank : 579)
Query Neighborhood Hits	531	Target Neighborhood Hits	438	Shared Neighborhood Hits	158
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

AUTS2_HUMAN
NC score	0.122406 (rank : 234)	θ value	0.0961366 (rank : 140)
Query Neighborhood Hits	531	Target Neighborhood Hits	342	Shared Neighborhood Hits	95
SwissProt Accessions	Q8WXX7, Q9Y4F2	Gene names	AUTS2, KIAA0442
Domain Architecture	No domain graphic available
Description	Autism susceptibility gene 2 protein.

FYB_MOUSE
NC score	0.122356 (rank : 235)	θ value	0.00869519 (rank : 67)
Query Neighborhood Hits	531	Target Neighborhood Hits	194	Shared Neighborhood Hits	42
SwissProt Accessions	O35601, Q9Z2H3	Gene names	Fyb
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

PELP1_MOUSE
NC score	0.122147 (rank : 236)	θ value	θ > 10 (rank : 867)
Query Neighborhood Hits	531	Target Neighborhood Hits	709	Shared Neighborhood Hits	147
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

MNT_HUMAN
NC score	0.121926 (rank : 237)	θ value	0.62314 (rank : 250)
Query Neighborhood Hits	531	Target Neighborhood Hits	496	Shared Neighborhood Hits	129
SwissProt Accessions	Q99583	Gene names	MNT, ROX
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

RNC_HUMAN
NC score	0.121814 (rank : 238)	θ value	0.00869519 (rank : 69)
Query Neighborhood Hits	531	Target Neighborhood Hits	176	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NRR4, Q7Z5V2, Q86YH0, Q9NW73, Q9Y2V9, Q9Y4Y0	Gene names	RNASEN, RN3, RNASE3L
Domain Architecture
Description	Ribonuclease III (EC 3.1.26.3) (RNase III) (Drosha) (p241).

BRD4_HUMAN
NC score	0.120616 (rank : 239)	θ value	0.0961366 (rank : 141)
Query Neighborhood Hits	531	Target Neighborhood Hits	851	Shared Neighborhood Hits	150
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CN155_HUMAN
NC score	0.120081 (rank : 240)	θ value	8.99809 (rank : 508)
Query Neighborhood Hits	531	Target Neighborhood Hits	385	Shared Neighborhood Hits	90
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

SH23A_HUMAN
NC score	0.120079 (rank : 241)	θ value	3.0926 (rank : 382)
Query Neighborhood Hits	531	Target Neighborhood Hits	149	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BRG2, Q9Y2X4	Gene names	SH2D3A, NSP1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3A (Novel SH2-containing protein 1).

TAB3_MOUSE
NC score	0.119875 (rank : 242)	θ value	0.279714 (rank : 210)
Query Neighborhood Hits	531	Target Neighborhood Hits	273	Shared Neighborhood Hits	82
SwissProt Accessions	Q571K4	Gene names	Map3k7ip3, Kiaa4135, Tab3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3).

TENS1_HUMAN
NC score	0.119834 (rank : 243)	θ value	0.00869519 (rank : 71)
Query Neighborhood Hits	531	Target Neighborhood Hits	400	Shared Neighborhood Hits	118
SwissProt Accessions	Q9HBL0	Gene names	TNS1, TNS
Domain Architecture	No domain graphic available
Description	Tensin-1.

HCLS1_HUMAN
NC score	0.119163 (rank : 244)	θ value	θ > 10 (rank : 737)
Query Neighborhood Hits	531	Target Neighborhood Hits	358	Shared Neighborhood Hits	122
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

FMN2_HUMAN
NC score	0.119158 (rank : 245)	θ value	0.365318 (rank : 215)
Query Neighborhood Hits	531	Target Neighborhood Hits	484	Shared Neighborhood Hits	106
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

HSH2D_HUMAN
NC score	0.118999 (rank : 246)	θ value	θ > 10 (rank : 741)
Query Neighborhood Hits	531	Target Neighborhood Hits	159	Shared Neighborhood Hits	69
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

WASF3_MOUSE
NC score	0.118960 (rank : 247)	θ value	θ > 10 (rank : 1053)
Query Neighborhood Hits	531	Target Neighborhood Hits	188	Shared Neighborhood Hits	55
SwissProt Accessions	Q8VHI6	Gene names	Wasf3, Wave3
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 3 (WASP-family protein member 3) (Protein WAVE-3).

APS_MOUSE
NC score	0.118567 (rank : 248)	θ value	θ > 10 (rank : 561)
Query Neighborhood Hits	531	Target Neighborhood Hits	134	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

RBM12_MOUSE
NC score	0.118293 (rank : 249)	θ value	0.00228821 (rank : 51)
Query Neighborhood Hits	531	Target Neighborhood Hits	313	Shared Neighborhood Hits	62
SwissProt Accessions	Q8R4X3, Q8K373, Q8R302, Q9CS80	Gene names	Rbm12
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

CSKI1_MOUSE
NC score	0.117879 (rank : 250)	θ value	0.0431538 (rank : 112)
Query Neighborhood Hits	531	Target Neighborhood Hits	1031	Shared Neighborhood Hits	219
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ANK2_HUMAN
NC score	0.117775 (rank : 251)	θ value	0.0252991 (rank : 96)
Query Neighborhood Hits	531	Target Neighborhood Hits	1615	Shared Neighborhood Hits	238
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

MBB1A_HUMAN
NC score	0.117562 (rank : 252)	θ value	θ > 10 (rank : 806)
Query Neighborhood Hits	531	Target Neighborhood Hits	665	Shared Neighborhood Hits	151
SwissProt Accessions	Q9BQG0, Q86VM3, Q9BW49, Q9P0V5, Q9UF99	Gene names	MYBBP1A, P160
Domain Architecture	No domain graphic available
Description	Myb-binding protein 1A.

BRD4_MOUSE
NC score	0.117200 (rank : 253)	θ value	0.0148317 (rank : 79)
Query Neighborhood Hits	531	Target Neighborhood Hits	845	Shared Neighborhood Hits	129
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

YES_MOUSE
NC score	0.117165 (rank : 254)	θ value	0.163984 (rank : 172)
Query Neighborhood Hits	531	Target Neighborhood Hits	1052	Shared Neighborhood Hits	100
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.117163 (rank : 255)	θ value	0.125558 (rank : 152)
Query Neighborhood Hits	531	Target Neighborhood Hits	1073	Shared Neighborhood Hits	102
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

YES_HUMAN
NC score	0.116929 (rank : 256)	θ value	0.21417 (rank : 186)
Query Neighborhood Hits	531	Target Neighborhood Hits	1059	Shared Neighborhood Hits	101
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PS1C2_MOUSE
NC score	0.116647 (rank : 257)	θ value	0.813845 (rank : 268)
Query Neighborhood Hits	531	Target Neighborhood Hits	59	Shared Neighborhood Hits	20
SwissProt Accessions	Q80ZC9	Gene names	Psors1c2, Spr1
Domain Architecture	No domain graphic available
Description	Psoriasis susceptibility 1 candidate gene 2 protein homolog precursor (SPR1 protein).

FYN_HUMAN
NC score	0.115544 (rank : 258)	θ value	0.125558 (rank : 151)
Query Neighborhood Hits	531	Target Neighborhood Hits	1078	Shared Neighborhood Hits	103
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

CSF1_HUMAN
NC score	0.115195 (rank : 259)	θ value	θ > 10 (rank : 622)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	81
SwissProt Accessions	P09603, Q13130, Q14086, Q14806, Q9UQR8	Gene names	CSF1
Domain Architecture
Description	Macrophage colony-stimulating factor 1 precursor (CSF-1) (MCSF) (M- CSF) (Lanimostim).

JPH2_HUMAN
NC score	0.114975 (rank : 260)	θ value	6.88961 (rank : 476)
Query Neighborhood Hits	531	Target Neighborhood Hits	639	Shared Neighborhood Hits	173
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

ZN385_HUMAN
NC score	0.114321 (rank : 261)	θ value	θ > 10 (rank : 1061)
Query Neighborhood Hits	531	Target Neighborhood Hits	614	Shared Neighborhood Hits	155
SwissProt Accessions	Q96PM9, Q5VH53, Q9H7R6, Q9UFU3	Gene names	ZNF385, HZF, RZF
Domain Architecture
Description	Zinc finger protein 385 (Hematopoietic zinc finger protein) (Retinal zinc finger protein).

TEC_HUMAN
NC score	0.114179 (rank : 262)	θ value	0.0736092 (rank : 138)
Query Neighborhood Hits	531	Target Neighborhood Hits	1006	Shared Neighborhood Hits	93
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

WBS14_HUMAN
NC score	0.113953 (rank : 263)	θ value	0.0113563 (rank : 77)
Query Neighborhood Hits	531	Target Neighborhood Hits	273	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NP71, Q96E48, Q9BY03, Q9BY04, Q9BY05, Q9BY06, Q9Y2P3	Gene names	MLXIPL, MIO, WBSCR14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein (WS basic-helix- loop-helix leucine zipper protein) (WS-bHLH) (Mlx interactor) (MLX- interacting protein-like).

TULP4_HUMAN
NC score	0.113937 (rank : 264)	θ value	θ > 10 (rank : 1028)
Query Neighborhood Hits	531	Target Neighborhood Hits	426	Shared Neighborhood Hits	123
SwissProt Accessions	Q9NRJ4, Q9HD22, Q9P2F0	Gene names	TULP4, KIAA1397, TUSP
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

TARA_MOUSE
NC score	0.113818 (rank : 265)	θ value	θ > 10 (rank : 1005)
Query Neighborhood Hits	531	Target Neighborhood Hits	1133	Shared Neighborhood Hits	170
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TXK_HUMAN
NC score	0.113763 (rank : 266)	θ value	0.0431538 (rank : 116)
Query Neighborhood Hits	531	Target Neighborhood Hits	971	Shared Neighborhood Hits	91
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

TXK_MOUSE
NC score	0.113251 (rank : 267)	θ value	0.125558 (rank : 157)
Query Neighborhood Hits	531	Target Neighborhood Hits	980	Shared Neighborhood Hits	93
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

NUMBL_HUMAN
NC score	0.113181 (rank : 268)	θ value	θ > 10 (rank : 850)
Query Neighborhood Hits	531	Target Neighborhood Hits	394	Shared Neighborhood Hits	127
SwissProt Accessions	Q9Y6R0, Q7Z4J9	Gene names	NUMBL
Domain Architecture
Description	Numb-like protein (Numb-R).

PCQAP_MOUSE
NC score	0.113006 (rank : 269)	θ value	0.279714 (rank : 198)
Query Neighborhood Hits	531	Target Neighborhood Hits	506	Shared Neighborhood Hits	78
SwissProt Accessions	Q924H2	Gene names	Pcqap
Domain Architecture	No domain graphic available
Description	Positive cofactor 2 glutamine/Q-rich-associated protein (PC2 glutamine/Q-rich-associated protein) (mPcqap).

FMN2_MOUSE
NC score	0.112867 (rank : 270)	θ value	θ > 10 (rank : 715)
Query Neighborhood Hits	531	Target Neighborhood Hits	349	Shared Neighborhood Hits	103
SwissProt Accessions	Q9JL04	Gene names	Fmn2
Domain Architecture
Description	Formin-2.

HCK_MOUSE
NC score	0.111973 (rank : 271)	θ value	0.0330416 (rank : 107)
Query Neighborhood Hits	531	Target Neighborhood Hits	1029	Shared Neighborhood Hits	99
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

ASPP2_HUMAN
NC score	0.111972 (rank : 272)	θ value	0.0961366 (rank : 139)
Query Neighborhood Hits	531	Target Neighborhood Hits	1156	Shared Neighborhood Hits	149
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

TAU_MOUSE
NC score	0.111897 (rank : 273)	θ value	0.813845 (rank : 274)
Query Neighborhood Hits	531	Target Neighborhood Hits	502	Shared Neighborhood Hits	125
SwissProt Accessions	P10637, P10638, Q60684, Q60685, Q60686, Q62286	Gene names	Mapt, Mtapt, Tau
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

EFS_MOUSE
NC score	0.111780 (rank : 274)	θ value	θ > 10 (rank : 650)
Query Neighborhood Hits	531	Target Neighborhood Hits	389	Shared Neighborhood Hits	128
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

HCK_HUMAN
NC score	0.111638 (rank : 275)	θ value	0.0330416 (rank : 106)
Query Neighborhood Hits	531	Target Neighborhood Hits	1035	Shared Neighborhood Hits	98
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

ABL1_MOUSE
NC score	0.111522 (rank : 276)	θ value	θ > 10 (rank : 542)
Query Neighborhood Hits	531	Target Neighborhood Hits	1178	Shared Neighborhood Hits	141
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TEC_MOUSE
NC score	0.111421 (rank : 277)	θ value	0.163984 (rank : 171)
Query Neighborhood Hits	531	Target Neighborhood Hits	1006	Shared Neighborhood Hits	90
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

PRPC_HUMAN
NC score	0.111412 (rank : 278)	θ value	θ > 10 (rank : 889)
Query Neighborhood Hits	531	Target Neighborhood Hits	165	Shared Neighborhood Hits	43
SwissProt Accessions	P02810, Q4VBP2, Q53XA2, Q6P2F6	Gene names	PRH1
Domain Architecture	No domain graphic available
Description	Salivary acidic proline-rich phosphoprotein 1/2 precursor (PRP-1/PRP- 2) (Parotid proline-rich protein 1/2) (Pr1/Pr2) (Protein C) (Parotid acidic protein) (Pa) (Parotid isoelectric focusing variant protein) (PIF-S) (Parotid double-band protein) (Db-s) [Contains: Salivary acidic proline-rich phosphoprotein 1/2; Salivary acidic proline-rich phosphoprotein 3/4 (PRP-3/PRP-4) (Protein A) (PIF-F) (Db-F); Peptide P-C].

SH2D3_HUMAN
NC score	0.111349 (rank : 279)	θ value	θ > 10 (rank : 940)
Query Neighborhood Hits	531	Target Neighborhood Hits	188	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

BMX_HUMAN
NC score	0.111137 (rank : 280)	θ value	0.0148317 (rank : 78)
Query Neighborhood Hits	531	Target Neighborhood Hits	942	Shared Neighborhood Hits	89
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

TROAP_HUMAN
NC score	0.111118 (rank : 281)	θ value	8.99809 (rank : 528)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	89
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

SH2D3_MOUSE
NC score	0.111051 (rank : 282)	θ value	θ > 10 (rank : 941)
Query Neighborhood Hits	531	Target Neighborhood Hits	174	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

BMX_MOUSE
NC score	0.110938 (rank : 283)	θ value	0.0193708 (rank : 89)
Query Neighborhood Hits	531	Target Neighborhood Hits	912	Shared Neighborhood Hits	88
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

IASPP_HUMAN
NC score	0.110849 (rank : 284)	θ value	4.03905 (rank : 404)
Query Neighborhood Hits	531	Target Neighborhood Hits	688	Shared Neighborhood Hits	138
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CSKI1_HUMAN
NC score	0.110396 (rank : 285)	θ value	0.000121331 (rank : 20)
Query Neighborhood Hits	531	Target Neighborhood Hits	997	Shared Neighborhood Hits	183
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ATX7_MOUSE
NC score	0.109461 (rank : 286)	θ value	θ > 10 (rank : 574)
Query Neighborhood Hits	531	Target Neighborhood Hits	328	Shared Neighborhood Hits	125
SwissProt Accessions	Q8R4I1, Q8BL17	Gene names	Atxn7, Sca7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein homolog).

AFF1_MOUSE
NC score	0.109372 (rank : 287)	θ value	0.0431538 (rank : 111)
Query Neighborhood Hits	531	Target Neighborhood Hits	351	Shared Neighborhood Hits	78
SwissProt Accessions	O88573	Gene names	Aff1, Mllt2, Mllt2h
Domain Architecture
Description	AF4/FMR2 family member 1 (Protein AF-4) (Proto-oncogene AF4).

R3HD2_MOUSE
NC score	0.109211 (rank : 288)	θ value	θ > 10 (rank : 898)
Query Neighborhood Hits	531	Target Neighborhood Hits	397	Shared Neighborhood Hits	110
SwissProt Accessions	Q80TM6, Q80YB1, Q8BLS5, Q9CW50	Gene names	R3hdm2, Kiaa1002
Domain Architecture
Description	R3H domain-containing protein 2.

ABL1_HUMAN
NC score	0.108898 (rank : 289)	θ value	θ > 10 (rank : 541)
Query Neighborhood Hits	531	Target Neighborhood Hits	1220	Shared Neighborhood Hits	137
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

K1543_HUMAN
NC score	0.108704 (rank : 290)	θ value	θ > 10 (rank : 772)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	135
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

LYN_MOUSE
NC score	0.108608 (rank : 291)	θ value	0.0563607 (rank : 121)
Query Neighborhood Hits	531	Target Neighborhood Hits	1023	Shared Neighborhood Hits	94
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CIC_MOUSE
NC score	0.108586 (rank : 292)	θ value	0.0252991 (rank : 97)
Query Neighborhood Hits	531	Target Neighborhood Hits	742	Shared Neighborhood Hits	153
SwissProt Accessions	Q924A2, Q6PDJ8, Q8CGE4, Q8CHH0, Q9CW61	Gene names	Cic, Kiaa0306
Domain Architecture	No domain graphic available
Description	Protein capicua homolog.

LYN_HUMAN
NC score	0.108410 (rank : 293)	θ value	0.0431538 (rank : 114)
Query Neighborhood Hits	531	Target Neighborhood Hits	1022	Shared Neighborhood Hits	94
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

ATX1_MOUSE
NC score	0.108206 (rank : 294)	θ value	θ > 10 (rank : 570)
Query Neighborhood Hits	531	Target Neighborhood Hits	264	Shared Neighborhood Hits	97
SwissProt Accessions	P54254	Gene names	Atxn1, Sca1
Domain Architecture
Description	Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog).

BCAR3_MOUSE
NC score	0.107897 (rank : 295)	θ value	θ > 10 (rank : 581)
Query Neighborhood Hits	531	Target Neighborhood Hits	127	Shared Neighborhood Hits	55
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

RBM12_HUMAN
NC score	0.107877 (rank : 296)	θ value	0.0193708 (rank : 92)
Query Neighborhood Hits	531	Target Neighborhood Hits	298	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NTZ6, O94865, Q8N3B1, Q9H196	Gene names	RBM12, KIAA0765
Domain Architecture
Description	RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN).

MEF2B_MOUSE
NC score	0.107580 (rank : 297)	θ value	0.163984 (rank : 163)
Query Neighborhood Hits	531	Target Neighborhood Hits	218	Shared Neighborhood Hits	70
SwissProt Accessions	O55087, O55088, O55089, O55090, O55231, Q61843	Gene names	Mef2b
Domain Architecture
Description	Myocyte-specific enhancer factor 2B.

NCOR2_HUMAN
NC score	0.107418 (rank : 298)	θ value	1.38821 (rank : 303)
Query Neighborhood Hits	531	Target Neighborhood Hits	870	Shared Neighborhood Hits	149
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

BCAR3_HUMAN
NC score	0.107373 (rank : 299)	θ value	θ > 10 (rank : 580)
Query Neighborhood Hits	531	Target Neighborhood Hits	129	Shared Neighborhood Hits	53
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

TCOF_MOUSE
NC score	0.107342 (rank : 300)	θ value	0.0148317 (rank : 86)
Query Neighborhood Hits	531	Target Neighborhood Hits	471	Shared Neighborhood Hits	75
SwissProt Accessions	O08784, O08857	Gene names	Tcof1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein homolog).

MBD5_HUMAN
NC score	0.107211 (rank : 301)	θ value	0.62314 (rank : 248)
Query Neighborhood Hits	531	Target Neighborhood Hits	176	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P267, Q9NUV6	Gene names	MBD5, KIAA1461
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).

MAP4_HUMAN
NC score	0.106839 (rank : 302)	θ value	6.88961 (rank : 479)
Query Neighborhood Hits	531	Target Neighborhood Hits	428	Shared Neighborhood Hits	109
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

FRK_HUMAN
NC score	0.106531 (rank : 303)	θ value	θ > 10 (rank : 717)
Query Neighborhood Hits	531	Target Neighborhood Hits	1058	Shared Neighborhood Hits	102
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ITK_HUMAN
NC score	0.106324 (rank : 304)	θ value	0.813845 (rank : 262)
Query Neighborhood Hits	531	Target Neighborhood Hits	1016	Shared Neighborhood Hits	91
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
NC score	0.106260 (rank : 305)	θ value	1.06291 (rank : 283)
Query Neighborhood Hits	531	Target Neighborhood Hits	985	Shared Neighborhood Hits	89
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

ATX2_MOUSE
NC score	0.106224 (rank : 306)	θ value	θ > 10 (rank : 573)
Query Neighborhood Hits	531	Target Neighborhood Hits	445	Shared Neighborhood Hits	125
SwissProt Accessions	O70305, P97421	Gene names	Atxn2, Atx2, Sca2
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein homolog).

ABL2_HUMAN
NC score	0.105976 (rank : 307)	θ value	θ > 10 (rank : 543)
Query Neighborhood Hits	531	Target Neighborhood Hits	1045	Shared Neighborhood Hits	110
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

OGFR_MOUSE
NC score	0.105873 (rank : 308)	θ value	θ > 10 (rank : 854)
Query Neighborhood Hits	531	Target Neighborhood Hits	584	Shared Neighborhood Hits	123
SwissProt Accessions	Q99PG2, Q99L33	Gene names	Ogfr
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor).

CRTC1_HUMAN
NC score	0.105464 (rank : 309)	θ value	θ > 10 (rank : 616)
Query Neighborhood Hits	531	Target Neighborhood Hits	319	Shared Neighborhood Hits	115
SwissProt Accessions	Q6UUV9, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801	Gene names	CRTC1, KIAA0616, MECT1, TORC1, WAMTP1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Transducer of regulated cAMP response element-binding protein 1) (Transducer of CREB protein 1) (Mucoepidermoid carcinoma translocated protein 1).

NRX2B_HUMAN
NC score	0.105115 (rank : 310)	θ value	θ > 10 (rank : 843)
Query Neighborhood Hits	531	Target Neighborhood Hits	481	Shared Neighborhood Hits	140
SwissProt Accessions	P58401	Gene names	NRXN2
Domain Architecture	No domain graphic available
Description	Neurexin-2-beta precursor (Neurexin II-beta).

SMR3A_HUMAN
NC score	0.104859 (rank : 311)	θ value	8.99809 (rank : 525)
Query Neighborhood Hits	531	Target Neighborhood Hits	93	Shared Neighborhood Hits	41
SwissProt Accessions	Q99954	Gene names	SMR3A, PBI, PROL5
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 3 homolog A precursor (Proline-rich protein 5) (Proline-rich protein PBI).

CRSP2_HUMAN
NC score	0.104598 (rank : 312)	θ value	θ > 10 (rank : 615)
Query Neighborhood Hits	531	Target Neighborhood Hits	380	Shared Neighborhood Hits	118
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

CS016_HUMAN
NC score	0.104115 (rank : 313)	θ value	θ > 10 (rank : 619)
Query Neighborhood Hits	531	Target Neighborhood Hits	310	Shared Neighborhood Hits	86
SwissProt Accessions	Q8ND99	Gene names	C19orf16
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf16.

GAB1_HUMAN
NC score	0.104076 (rank : 314)	θ value	5.27518 (rank : 435)
Query Neighborhood Hits	531	Target Neighborhood Hits	279	Shared Neighborhood Hits	106
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

SYNJ1_MOUSE
NC score	0.104073 (rank : 315)	θ value	6.88961 (rank : 493)
Query Neighborhood Hits	531	Target Neighborhood Hits	516	Shared Neighborhood Hits	153
SwissProt Accessions	Q8CHC4	Gene names	Synj1, Kiaa0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

LCK_HUMAN
NC score	0.103823 (rank : 316)	θ value	θ > 10 (rank : 786)
Query Neighborhood Hits	531	Target Neighborhood Hits	987	Shared Neighborhood Hits	92
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
NC score	0.103296 (rank : 317)	θ value	θ > 10 (rank : 787)
Query Neighborhood Hits	531	Target Neighborhood Hits	981	Shared Neighborhood Hits	93
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

GAK5_HUMAN
NC score	0.103288 (rank : 318)	θ value	1.81305 (rank : 323)
Query Neighborhood Hits	531	Target Neighborhood Hits	429	Shared Neighborhood Hits	163
SwissProt Accessions	P62684	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19p13.11 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K113 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

BAZ2A_MOUSE
NC score	0.102923 (rank : 319)	θ value	θ > 10 (rank : 578)
Query Neighborhood Hits	531	Target Neighborhood Hits	744	Shared Neighborhood Hits	159
SwissProt Accessions	Q91YE5	Gene names	Baz2a, Tip5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5).

BLK_MOUSE
NC score	0.102827 (rank : 320)	θ value	θ > 10 (rank : 584)
Query Neighborhood Hits	531	Target Neighborhood Hits	992	Shared Neighborhood Hits	95
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SHAN1_HUMAN
NC score	0.102614 (rank : 321)	θ value	0.00175202 (rank : 45)
Query Neighborhood Hits	531	Target Neighborhood Hits	1041	Shared Neighborhood Hits	142
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

GAB1_MOUSE
NC score	0.102491 (rank : 322)	θ value	1.81305 (rank : 320)
Query Neighborhood Hits	531	Target Neighborhood Hits	233	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

ATX2L_HUMAN
NC score	0.102432 (rank : 323)	θ value	θ > 10 (rank : 571)
Query Neighborhood Hits	531	Target Neighborhood Hits	443	Shared Neighborhood Hits	117
SwissProt Accessions	Q8WWM7, O95135, Q6NVJ8, Q6PJW6, Q8IU61, Q8IU95, Q8WWM3, Q8WWM4, Q8WWM5, Q8WWM6, Q99703	Gene names	ATXN2L, A2D, A2LG, A2LP, A2RP
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein (Ataxin-2 domain protein) (Ataxin-2-related protein).

MUC2_HUMAN
NC score	0.102420 (rank : 324)	θ value	0.000786445 (rank : 33)
Query Neighborhood Hits	531	Target Neighborhood Hits	906	Shared Neighborhood Hits	121
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

PTK6_MOUSE
NC score	0.102099 (rank : 325)	θ value	0.0330416 (rank : 109)
Query Neighborhood Hits	531	Target Neighborhood Hits	1026	Shared Neighborhood Hits	91
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SH22A_HUMAN
NC score	0.102041 (rank : 326)	θ value	θ > 10 (rank : 936)
Query Neighborhood Hits	531	Target Neighborhood Hits	144	Shared Neighborhood Hits	60
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

TAF4_HUMAN
NC score	0.102021 (rank : 327)	θ value	θ > 10 (rank : 1004)
Query Neighborhood Hits	531	Target Neighborhood Hits	687	Shared Neighborhood Hits	120
SwissProt Accessions	O00268, Q5TBP6, Q99721, Q9BR40, Q9BX42	Gene names	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135
Domain Architecture
Description	Transcription initiation factor TFIID subunit 4 (TBP-associated factor 4) (Transcription initiation factor TFIID 135 kDa subunit) (TAF(II)135) (TAFII-135) (TAFII135) (TAFII-130) (TAFII130).

PRP5_HUMAN
NC score	0.101930 (rank : 328)	θ value	θ > 10 (rank : 888)
Query Neighborhood Hits	531	Target Neighborhood Hits	108	Shared Neighborhood Hits	34
SwissProt Accessions	P04281	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide IB-1.

TENS4_HUMAN
NC score	0.101836 (rank : 329)	θ value	θ > 10 (rank : 1012)
Query Neighborhood Hits	531	Target Neighborhood Hits	214	Shared Neighborhood Hits	84
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

LR37A_HUMAN
NC score	0.101726 (rank : 330)	θ value	4.03905 (rank : 408)
Query Neighborhood Hits	531	Target Neighborhood Hits	720	Shared Neighborhood Hits	122
SwissProt Accessions	O60309, Q49A01, Q49A80, Q8NB33	Gene names	LRRC37A, KIAA0563
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37A.

ALEX_MOUSE
NC score	0.101401 (rank : 331)	θ value	0.47712 (rank : 227)
Query Neighborhood Hits	531	Target Neighborhood Hits	197	Shared Neighborhood Hits	53
SwissProt Accessions	Q6R0H6, Q8BIR3	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Protein ALEX (Alternative gene product encoded by XL-exon).

BLK_HUMAN
NC score	0.101279 (rank : 332)	θ value	θ > 10 (rank : 583)
Query Neighborhood Hits	531	Target Neighborhood Hits	994	Shared Neighborhood Hits	95
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

MTSS1_HUMAN
NC score	0.101240 (rank : 333)	θ value	θ > 10 (rank : 818)
Query Neighborhood Hits	531	Target Neighborhood Hits	504	Shared Neighborhood Hits	113
SwissProt Accessions	O43312, Q8TCA2, Q96RX2	Gene names	MTSS1, KIAA0429, MIM
Domain Architecture	No domain graphic available
Description	Metastasis suppressor protein 1 (Missing in metastasis protein) (Metastasis suppressor YGL-1).

NSD1_HUMAN
NC score	0.100799 (rank : 334)	θ value	1.81305 (rank : 328)
Query Neighborhood Hits	531	Target Neighborhood Hits	427	Shared Neighborhood Hits	81
SwissProt Accessions	Q96L73, Q96PD8, Q96RN7	Gene names	NSD1, ARA267
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) (Androgen receptor-associated coregulator 267).

NIPBL_HUMAN
NC score	0.100581 (rank : 335)	θ value	θ > 10 (rank : 837)
Query Neighborhood Hits	531	Target Neighborhood Hits	1311	Shared Neighborhood Hits	163
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

SYNJ1_HUMAN
NC score	0.100397 (rank : 336)	θ value	0.163984 (rank : 170)
Query Neighborhood Hits	531	Target Neighborhood Hits	498	Shared Neighborhood Hits	140
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

DAB1_HUMAN
NC score	0.100320 (rank : 337)	θ value	4.03905 (rank : 396)
Query Neighborhood Hits	531	Target Neighborhood Hits	219	Shared Neighborhood Hits	82
SwissProt Accessions	O75553, Q9NYA8	Gene names	DAB1
Domain Architecture
Description	Disabled homolog 1.

SGIP1_HUMAN
NC score	0.100268 (rank : 338)	θ value	0.279714 (rank : 205)
Query Neighborhood Hits	531	Target Neighborhood Hits	198	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

GAK4_HUMAN
NC score	0.100160 (rank : 339)	θ value	5.27518 (rank : 439)
Query Neighborhood Hits	531	Target Neighborhood Hits	415	Shared Neighborhood Hits	160
SwissProt Accessions	P63126, Q9UKH4	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_6q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K109 Gag protein) (HERV-K(C6) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

CSK_HUMAN
NC score	0.100108 (rank : 340)	θ value	θ > 10 (rank : 624)
Query Neighborhood Hits	531	Target Neighborhood Hits	1009	Shared Neighborhood Hits	94
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
NC score	0.100064 (rank : 341)	θ value	θ > 10 (rank : 625)
Query Neighborhood Hits	531	Target Neighborhood Hits	1009	Shared Neighborhood Hits	94
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

ABI2_HUMAN
NC score	0.100034 (rank : 342)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	531	Target Neighborhood Hits	350	Shared Neighborhood Hits	84
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

GAK2_HUMAN
NC score	0.099571 (rank : 343)	θ value	1.81305 (rank : 321)
Query Neighborhood Hits	531	Target Neighborhood Hits	406	Shared Neighborhood Hits	155
SwissProt Accessions	Q7LDI9, Q9UKH5, Q9Y6I1, Q9YNA6, Q9YNB0	Gene names	ERVK6
Domain Architecture	No domain graphic available
Description	HERV-K_7p22.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(HML-2.HOM) Gag protein) (HERV-K108 Gag protein) (HERV-K(C7) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

BASP_HUMAN
NC score	0.099521 (rank : 344)	θ value	2.36792 (rank : 335)
Query Neighborhood Hits	531	Target Neighborhood Hits	321	Shared Neighborhood Hits	55
SwissProt Accessions	P80723, O43596, Q5U0S0	Gene names	BASP1, NAP22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

TP53B_MOUSE
NC score	0.099506 (rank : 345)	θ value	θ > 10 (rank : 1024)
Query Neighborhood Hits	531	Target Neighborhood Hits	644	Shared Neighborhood Hits	122
SwissProt Accessions	P70399, Q68FD0, Q8CI97, Q91YC9	Gene names	Tp53bp1, Trp53bp1
Domain Architecture	No domain graphic available
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

S23IP_MOUSE
NC score	0.099470 (rank : 346)	θ value	2.36792 (rank : 352)
Query Neighborhood Hits	531	Target Neighborhood Hits	363	Shared Neighborhood Hits	116
SwissProt Accessions	Q6NZC7, Q8BXY6	Gene names	Sec23ip
Domain Architecture	No domain graphic available
Description	SEC23-interacting protein.

MNT_MOUSE
NC score	0.099438 (rank : 347)	θ value	1.38821 (rank : 302)
Query Neighborhood Hits	531	Target Neighborhood Hits	432	Shared Neighborhood Hits	85
SwissProt Accessions	O08789, P97349	Gene names	Mnt, Rox
Domain Architecture
Description	Max-binding protein MNT (Protein ROX) (Myc antagonist MNT).

GAK11_HUMAN
NC score	0.099355 (rank : 348)	θ value	5.27518 (rank : 436)
Query Neighborhood Hits	531	Target Neighborhood Hits	409	Shared Neighborhood Hits	158
SwissProt Accessions	P63145, Q9UKI1	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_22q11.21 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K101 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

GRIN1_HUMAN
NC score	0.099278 (rank : 349)	θ value	θ > 10 (rank : 732)
Query Neighborhood Hits	531	Target Neighborhood Hits	681	Shared Neighborhood Hits	137
SwissProt Accessions	Q7Z2K8, Q8ND74, Q96PZ4	Gene names	GPRIN1, KIAA1893
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

SYN1_HUMAN
NC score	0.098996 (rank : 350)	θ value	θ > 10 (rank : 998)
Query Neighborhood Hits	531	Target Neighborhood Hits	419	Shared Neighborhood Hits	107
SwissProt Accessions	P17600, O75825, Q5H9A9	Gene names	SYN1
Domain Architecture
Description	Synapsin-1 (Synapsin I) (Brain protein 4.1).

JADE2_MOUSE
NC score	0.098774 (rank : 351)	θ value	θ > 10 (rank : 764)
Query Neighborhood Hits	531	Target Neighborhood Hits	560	Shared Neighborhood Hits	145
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

BASP_MOUSE
NC score	0.098605 (rank : 352)	θ value	2.36792 (rank : 336)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	46
SwissProt Accessions	Q91XV3	Gene names	Basp1, Nap22
Domain Architecture	No domain graphic available
Description	Brain acid soluble protein 1 (BASP1 protein) (Neuronal axonal membrane protein NAP-22) (22 kDa neuronal tissue-enriched acidic protein).

PTN23_MOUSE
NC score	0.098140 (rank : 353)	θ value	0.0148317 (rank : 84)
Query Neighborhood Hits	531	Target Neighborhood Hits	726	Shared Neighborhood Hits	131
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

ZN750_MOUSE
NC score	0.097994 (rank : 354)	θ value	θ > 10 (rank : 1063)
Query Neighborhood Hits	531	Target Neighborhood Hits	346	Shared Neighborhood Hits	95
SwissProt Accessions	Q8BH05, Q66JP3, Q8C0L1	Gene names	Znf750
Domain Architecture	No domain graphic available
Description	Protein ZNF750.

CD248_HUMAN
NC score	0.097918 (rank : 355)	θ value	θ > 10 (rank : 594)
Query Neighborhood Hits	531	Target Neighborhood Hits	679	Shared Neighborhood Hits	156
SwissProt Accessions	Q9HCU0, Q3SX55, Q96KB6	Gene names	CD248, CD164L1, TEM1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

SOX13_HUMAN
NC score	0.097657 (rank : 356)	θ value	θ > 10 (rank : 969)
Query Neighborhood Hits	531	Target Neighborhood Hits	464	Shared Neighborhood Hits	144
SwissProt Accessions	Q9UN79, O95275, O95826, Q9UHW7	Gene names	SOX13
Domain Architecture
Description	SOX-13 protein (Type 1 diabetes autoantigen ICA12) (Islet cell antigen 12).

NPBL_MOUSE
NC score	0.097069 (rank : 357)	θ value	θ > 10 (rank : 839)
Query Neighborhood Hits	531	Target Neighborhood Hits	1041	Shared Neighborhood Hits	143
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

PO121_HUMAN
NC score	0.096985 (rank : 358)	θ value	1.06291 (rank : 288)
Query Neighborhood Hits	531	Target Neighborhood Hits	344	Shared Neighborhood Hits	74
SwissProt Accessions	Q9Y2N3, O75115, Q9Y4S7	Gene names	POM121, KIAA0618, NUP121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa) (P145).

SOCS3_HUMAN
NC score	0.096883 (rank : 359)	θ value	θ > 10 (rank : 962)
Query Neighborhood Hits	531	Target Neighborhood Hits	77	Shared Neighborhood Hits	38
SwissProt Accessions	O14543, O14509	Gene names	SOCS3, CIS3, SSI3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3).

NPHP1_MOUSE
NC score	0.096726 (rank : 360)	θ value	θ > 10 (rank : 841)
Query Neighborhood Hits	531	Target Neighborhood Hits	267	Shared Neighborhood Hits	46
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

GNAS1_MOUSE
NC score	0.096609 (rank : 361)	θ value	0.62314 (rank : 243)
Query Neighborhood Hits	531	Target Neighborhood Hits	651	Shared Neighborhood Hits	153
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

TM108_MOUSE
NC score	0.096577 (rank : 362)	θ value	θ > 10 (rank : 1021)
Query Neighborhood Hits	531	Target Neighborhood Hits	336	Shared Neighborhood Hits	91
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

PER3_HUMAN
NC score	0.096447 (rank : 363)	θ value	θ > 10 (rank : 869)
Query Neighborhood Hits	531	Target Neighborhood Hits	479	Shared Neighborhood Hits	131
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

SETBP_MOUSE
NC score	0.096420 (rank : 364)	θ value	0.813845 (rank : 271)
Query Neighborhood Hits	531	Target Neighborhood Hits	352	Shared Neighborhood Hits	98
SwissProt Accessions	Q9Z180, Q66JL8	Gene names	Setbp1, Kiaa0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

SRMS_MOUSE
NC score	0.096342 (rank : 365)	θ value	θ > 10 (rank : 986)
Query Neighborhood Hits	531	Target Neighborhood Hits	964	Shared Neighborhood Hits	87
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TENS4_MOUSE
NC score	0.096273 (rank : 366)	θ value	θ > 10 (rank : 1013)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	84
SwissProt Accessions	Q8BZ33, Q3TCM8, Q7TNR5	Gene names	Tns4
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor.

FER_HUMAN
NC score	0.095894 (rank : 367)	θ value	3.0926 (rank : 368)
Query Neighborhood Hits	531	Target Neighborhood Hits	1278	Shared Neighborhood Hits	108
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CO002_HUMAN
NC score	0.095893 (rank : 368)	θ value	θ > 10 (rank : 612)
Query Neighborhood Hits	531	Target Neighborhood Hits	387	Shared Neighborhood Hits	99
SwissProt Accessions	Q9NZP6	Gene names	C15orf2
Domain Architecture	No domain graphic available
Description	Protein C15orf2.

GAK6_HUMAN
NC score	0.095793 (rank : 369)	θ value	6.88961 (rank : 475)
Query Neighborhood Hits	531	Target Neighborhood Hits	392	Shared Neighborhood Hits	153
SwissProt Accessions	P62685	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_8p23.1 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K115 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

NOLC1_HUMAN
NC score	0.095758 (rank : 370)	θ value	6.88961 (rank : 481)
Query Neighborhood Hits	531	Target Neighborhood Hits	452	Shared Neighborhood Hits	75
SwissProt Accessions	Q14978, Q15030	Gene names	NOLC1, KIAA0035
Domain Architecture
Description	Nucleolar phosphoprotein p130 (Nucleolar 130 kDa protein) (140 kDa nucleolar phosphoprotein) (Nopp140) (Nucleolar and coiled-body phosphoprotein 1).

NSD1_MOUSE
NC score	0.095439 (rank : 371)	θ value	0.163984 (rank : 164)
Query Neighborhood Hits	531	Target Neighborhood Hits	472	Shared Neighborhood Hits	84
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

NCOR2_MOUSE
NC score	0.095402 (rank : 372)	θ value	0.62314 (rank : 251)
Query Neighborhood Hits	531	Target Neighborhood Hits	790	Shared Neighborhood Hits	129
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

SOCS3_MOUSE
NC score	0.095362 (rank : 373)	θ value	θ > 10 (rank : 963)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	39
SwissProt Accessions	O35718, P97803, Q3U7X5	Gene names	Socs3, Cis3, Cish3
Domain Architecture
Description	Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (Protein EF-10).

MINT_HUMAN
NC score	0.094810 (rank : 374)	θ value	3.0926 (rank : 375)
Query Neighborhood Hits	531	Target Neighborhood Hits	1291	Shared Neighborhood Hits	180
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ASPP1_HUMAN
NC score	0.094810 (rank : 375)	θ value	0.62314 (rank : 236)
Query Neighborhood Hits	531	Target Neighborhood Hits	956	Shared Neighborhood Hits	110
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

CS007_MOUSE
NC score	0.094647 (rank : 376)	θ value	θ > 10 (rank : 618)
Query Neighborhood Hits	531	Target Neighborhood Hits	464	Shared Neighborhood Hits	110
SwissProt Accessions	Q6ZPZ3	Gene names	Kiaa1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7 homolog.

OBF1_HUMAN
NC score	0.094534 (rank : 377)	θ value	θ > 10 (rank : 852)
Query Neighborhood Hits	531	Target Neighborhood Hits	203	Shared Neighborhood Hits	84
SwissProt Accessions	Q16633, Q14983	Gene names	POU2AF1, OBF1
Domain Architecture	No domain graphic available
Description	POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1) (OCT-binding factor 1) (BOB-1) (OCA-B).

PO121_MOUSE
NC score	0.094123 (rank : 378)	θ value	0.47712 (rank : 233)
Query Neighborhood Hits	531	Target Neighborhood Hits	345	Shared Neighborhood Hits	70
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

SRBP1_MOUSE
NC score	0.093898 (rank : 379)	θ value	0.47712 (rank : 234)
Query Neighborhood Hits	531	Target Neighborhood Hits	384	Shared Neighborhood Hits	110
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

SEPT9_HUMAN
NC score	0.093579 (rank : 380)	θ value	θ > 10 (rank : 925)
Query Neighborhood Hits	531	Target Neighborhood Hits	706	Shared Neighborhood Hits	174
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

K0310_HUMAN
NC score	0.093203 (rank : 381)	θ value	θ > 10 (rank : 770)
Query Neighborhood Hits	531	Target Neighborhood Hits	420	Shared Neighborhood Hits	120
SwissProt Accessions	O15027, Q5SXP0, Q5SXP1, Q8N347, Q96HP1	Gene names	KIAA0310
Domain Architecture	No domain graphic available
Description	Protein KIAA0310.

BAG3_HUMAN
NC score	0.093111 (rank : 382)	θ value	θ > 10 (rank : 575)
Query Neighborhood Hits	531	Target Neighborhood Hits	314	Shared Neighborhood Hits	92
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

HSH2D_MOUSE
NC score	0.093047 (rank : 383)	θ value	θ > 10 (rank : 742)
Query Neighborhood Hits	531	Target Neighborhood Hits	124	Shared Neighborhood Hits	50
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SRMS_HUMAN
NC score	0.092990 (rank : 384)	θ value	θ > 10 (rank : 985)
Query Neighborhood Hits	531	Target Neighborhood Hits	946	Shared Neighborhood Hits	83
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

PTK6_HUMAN
NC score	0.092521 (rank : 385)	θ value	θ > 10 (rank : 895)
Query Neighborhood Hits	531	Target Neighborhood Hits	1020	Shared Neighborhood Hits	90
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

CABIN_HUMAN
NC score	0.092361 (rank : 386)	θ value	θ > 10 (rank : 589)
Query Neighborhood Hits	531	Target Neighborhood Hits	490	Shared Neighborhood Hits	122
SwissProt Accessions	Q9Y6J0, Q9Y460	Gene names	CABIN1, KIAA0330
Domain Architecture
Description	Calcineurin-binding protein Cabin 1 (Calcineurin inhibitor) (CAIN).

SFR15_HUMAN
NC score	0.092300 (rank : 387)	θ value	θ > 10 (rank : 933)
Query Neighborhood Hits	531	Target Neighborhood Hits	368	Shared Neighborhood Hits	88
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

ACK1_HUMAN
NC score	0.092288 (rank : 388)	θ value	3.0926 (rank : 361)
Query Neighborhood Hits	531	Target Neighborhood Hits	1140	Shared Neighborhood Hits	173
SwissProt Accessions	Q07912, Q8N6U7, Q96H59	Gene names	TNK2, ACK1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine kinase non- receptor protein 2).

ATX2L_MOUSE
NC score	0.092157 (rank : 389)	θ value	θ > 10 (rank : 572)
Query Neighborhood Hits	531	Target Neighborhood Hits	401	Shared Neighborhood Hits	109
SwissProt Accessions	Q7TQH0, Q80XN9, Q8K059	Gene names	Atxn2l, A2lp
Domain Architecture	No domain graphic available
Description	Ataxin-2-like protein.

PHC2_HUMAN
NC score	0.091835 (rank : 390)	θ value	θ > 10 (rank : 875)
Query Neighborhood Hits	531	Target Neighborhood Hits	388	Shared Neighborhood Hits	126
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

MATK_HUMAN
NC score	0.091821 (rank : 391)	θ value	θ > 10 (rank : 803)
Query Neighborhood Hits	531	Target Neighborhood Hits	954	Shared Neighborhood Hits	95
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

ARID2_HUMAN
NC score	0.091708 (rank : 392)	θ value	0.813845 (rank : 259)
Query Neighborhood Hits	531	Target Neighborhood Hits	302	Shared Neighborhood Hits	61
SwissProt Accessions	Q68CP9, Q5EB51, Q645I3, Q6ZRY5, Q7Z3I5, Q86T28, Q96SJ6, Q9HCL5	Gene names	ARID2, KIAA1557
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 2 (ARID domain- containing protein 2) (BRG1-associated factor 200) (BAF200).

HCLS1_MOUSE
NC score	0.091479 (rank : 393)	θ value	θ > 10 (rank : 738)
Query Neighborhood Hits	531	Target Neighborhood Hits	329	Shared Neighborhood Hits	98
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

ZAP70_MOUSE
NC score	0.091151 (rank : 394)	θ value	0.163984 (rank : 173)
Query Neighborhood Hits	531	Target Neighborhood Hits	905	Shared Neighborhood Hits	89
SwissProt Accessions	P43404	Gene names	Zap70, Srk, Zap-70
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

GAK12_HUMAN
NC score	0.090942 (rank : 395)	θ value	5.27518 (rank : 437)
Query Neighborhood Hits	531	Target Neighborhood Hits	374	Shared Neighborhood Hits	147
SwissProt Accessions	P63130, Q9UKI0	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_1q22 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K102 Gag protein) (HERV-K(III) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MATK_MOUSE
NC score	0.090847 (rank : 396)	θ value	θ > 10 (rank : 804)
Query Neighborhood Hits	531	Target Neighborhood Hits	952	Shared Neighborhood Hits	94
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

TAB3_HUMAN
NC score	0.090791 (rank : 397)	θ value	0.0736092 (rank : 136)
Query Neighborhood Hits	531	Target Neighborhood Hits	168	Shared Neighborhood Hits	37
SwissProt Accessions	Q8N5C8, Q6VQR0	Gene names	MAP3K7IP3, TAB3
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 (TAK1-binding protein 3) (NF-kappa-B-activating protein 1).

AATK_HUMAN
NC score	0.090726 (rank : 398)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	531	Target Neighborhood Hits	1243	Shared Neighborhood Hits	186
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

CTDP1_HUMAN
NC score	0.090655 (rank : 399)	θ value	θ > 10 (rank : 628)
Query Neighborhood Hits	531	Target Neighborhood Hits	416	Shared Neighborhood Hits	102
SwissProt Accessions	Q9Y5B0, Q7Z644, Q96BZ1, Q9Y6F5	Gene names	CTDP1, FCP1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

SH24A_MOUSE
NC score	0.090116 (rank : 400)	θ value	θ > 10 (rank : 939)
Query Neighborhood Hits	531	Target Neighborhood Hits	326	Shared Neighborhood Hits	67
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

ZAP70_HUMAN
NC score	0.089998 (rank : 401)	θ value	0.21417 (rank : 187)
Query Neighborhood Hits	531	Target Neighborhood Hits	893	Shared Neighborhood Hits	91
SwissProt Accessions	P43403	Gene names	ZAP70, SRK
Domain Architecture
Description	Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-associated protein) (Syk-related tyrosine kinase).

HNRL1_MOUSE
NC score	0.089698 (rank : 402)	θ value	0.0252991 (rank : 100)
Query Neighborhood Hits	531	Target Neighborhood Hits	200	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VDM6, Q3U201, Q3UPB0, Q6AZA7, Q8BY45, Q8K365	Gene names	Hnrpul1
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1.

RC3H1_HUMAN
NC score	0.089645 (rank : 403)	θ value	1.38821 (rank : 304)
Query Neighborhood Hits	531	Target Neighborhood Hits	433	Shared Neighborhood Hits	109
SwissProt Accessions	Q5TC82, Q5W180, Q5W181, Q8IVE6, Q8N9V1	Gene names	RC3H1, KIAA2025
Domain Architecture	No domain graphic available
Description	Roquin (RING finger and C3H zinc finger protein 1).

SH3K1_HUMAN
NC score	0.089451 (rank : 404)	θ value	θ > 10 (rank : 945)
Query Neighborhood Hits	531	Target Neighborhood Hits	341	Shared Neighborhood Hits	62
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.089298 (rank : 405)	θ value	θ > 10 (rank : 946)
Query Neighborhood Hits	531	Target Neighborhood Hits	332	Shared Neighborhood Hits	63
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

KSYK_MOUSE
NC score	0.089257 (rank : 406)	θ value	θ > 10 (rank : 781)
Query Neighborhood Hits	531	Target Neighborhood Hits	944	Shared Neighborhood Hits	104
SwissProt Accessions	P48025	Gene names	Syk
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

CD2AP_MOUSE
NC score	0.089218 (rank : 407)	θ value	θ > 10 (rank : 597)
Query Neighborhood Hits	531	Target Neighborhood Hits	336	Shared Neighborhood Hits	67
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PTN23_HUMAN
NC score	0.088556 (rank : 408)	θ value	0.0961366 (rank : 144)
Query Neighborhood Hits	531	Target Neighborhood Hits	646	Shared Neighborhood Hits	104
SwissProt Accessions	Q9H3S7, Q7KZF8, Q8N6Z5, Q9BSR5, Q9P257, Q9UG03, Q9UMZ4	Gene names	PTPN23, KIAA1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His- domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14).

NPHP1_HUMAN
NC score	0.088282 (rank : 409)	θ value	θ > 10 (rank : 840)
Query Neighborhood Hits	531	Target Neighborhood Hits	288	Shared Neighborhood Hits	49
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NU214_HUMAN
NC score	0.088151 (rank : 410)	θ value	θ > 10 (rank : 848)
Query Neighborhood Hits	531	Target Neighborhood Hits	657	Shared Neighborhood Hits	105
SwissProt Accessions	P35658	Gene names	NUP214, CAIN, CAN
Domain Architecture
Description	Nuclear pore complex protein Nup214 (Nucleoporin Nup214) (214 kDa nucleoporin) (CAN protein).

PRCC_HUMAN
NC score	0.088108 (rank : 411)	θ value	0.813845 (rank : 267)
Query Neighborhood Hits	531	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q92733, O00665, O00724	Gene names	PRCC, TPRC
Domain Architecture	No domain graphic available
Description	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein).

CS007_HUMAN
NC score	0.088072 (rank : 412)	θ value	0.62314 (rank : 240)
Query Neighborhood Hits	531	Target Neighborhood Hits	401	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UPT8, Q9Y420	Gene names	C19orf7, KIAA1064
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein C19orf7.

CJ108_HUMAN
NC score	0.087954 (rank : 413)	θ value	θ > 10 (rank : 605)
Query Neighborhood Hits	531	Target Neighborhood Hits	165	Shared Neighborhood Hits	66
SwissProt Accessions	Q8N8Z3	Gene names	C10orf108
Domain Architecture	No domain graphic available
Description	Putative uncharacterized protein C10orf108.

SRBS1_MOUSE
NC score	0.087664 (rank : 414)	θ value	θ > 10 (rank : 982)
Query Neighborhood Hits	531	Target Neighborhood Hits	409	Shared Neighborhood Hits	92
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PHLB1_HUMAN
NC score	0.087570 (rank : 415)	θ value	θ > 10 (rank : 876)
Query Neighborhood Hits	531	Target Neighborhood Hits	1038	Shared Neighborhood Hits	165
SwissProt Accessions	Q86UU1, O75133, Q4KMF8, Q8TEQ2	Gene names	PHLDB1, DLNB07, KIAA0638, LL5A
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

CK024_MOUSE
NC score	0.087330 (rank : 416)	θ value	θ > 10 (rank : 607)
Query Neighborhood Hits	531	Target Neighborhood Hits	307	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D8N1, Q8VCP2	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 homolog precursor.

PRR13_HUMAN
NC score	0.086993 (rank : 417)	θ value	θ > 10 (rank : 891)
Query Neighborhood Hits	531	Target Neighborhood Hits	105	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

KSYK_HUMAN
NC score	0.086719 (rank : 418)	θ value	θ > 10 (rank : 780)
Query Neighborhood Hits	531	Target Neighborhood Hits	901	Shared Neighborhood Hits	86
SwissProt Accessions	P43405	Gene names	SYK
Domain Architecture
Description	Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase).

DIAP1_HUMAN
NC score	0.086425 (rank : 419)	θ value	0.279714 (rank : 192)
Query Neighborhood Hits	531	Target Neighborhood Hits	784	Shared Neighborhood Hits	95
SwissProt Accessions	O60610, Q9UC76	Gene names	DIAPH1, DIAP1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1).

BAT3_HUMAN
NC score	0.086079 (rank : 420)	θ value	θ > 10 (rank : 576)
Query Neighborhood Hits	531	Target Neighborhood Hits	490	Shared Neighborhood Hits	113
SwissProt Accessions	P46379, O95874, Q5SQ35, Q5SQ36, Q5SQ37, Q5SRP8, Q96SA6, Q9BCN4	Gene names	BAT3, G3
Domain Architecture
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3) (Protein G3).

SYNPO_HUMAN
NC score	0.085959 (rank : 421)	θ value	5.27518 (rank : 455)
Query Neighborhood Hits	531	Target Neighborhood Hits	281	Shared Neighborhood Hits	82
SwissProt Accessions	Q8N3V7, O15271, Q9UPX1	Gene names	SYNPO, KIAA1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

ACK1_MOUSE
NC score	0.085944 (rank : 422)	θ value	θ > 10 (rank : 545)
Query Neighborhood Hits	531	Target Neighborhood Hits	1080	Shared Neighborhood Hits	153
SwissProt Accessions	O54967, Q8C2U0, Q8K0K4	Gene names	Tnk2, Ack1
Domain Architecture
Description	Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2).

SOX13_MOUSE
NC score	0.085894 (rank : 423)	θ value	θ > 10 (rank : 970)
Query Neighborhood Hits	531	Target Neighborhood Hits	495	Shared Neighborhood Hits	150
SwissProt Accessions	Q04891, Q922L3	Gene names	Sox13, Sox-13
Domain Architecture
Description	SOX-13 protein.

SYNPO_MOUSE
NC score	0.085320 (rank : 424)	θ value	θ > 10 (rank : 1000)
Query Neighborhood Hits	531	Target Neighborhood Hits	242	Shared Neighborhood Hits	72
SwissProt Accessions	Q8CC35, Q99JI0	Gene names	Synpo, Kiaa1029
Domain Architecture	No domain graphic available
Description	Synaptopodin.

TAU_HUMAN
NC score	0.085253 (rank : 425)	θ value	θ > 10 (rank : 1006)
Query Neighborhood Hits	531	Target Neighborhood Hits	448	Shared Neighborhood Hits	111
SwissProt Accessions	P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q9UDJ3, Q9UMH0, Q9UQ96	Gene names	MAPT, MTBT1, TAU
Domain Architecture
Description	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau).

SYP2L_HUMAN
NC score	0.085249 (rank : 426)	θ value	0.0961366 (rank : 145)
Query Neighborhood Hits	531	Target Neighborhood Hits	400	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H987	Gene names	SYNPO2L
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

RAI1_MOUSE
NC score	0.085217 (rank : 427)	θ value	4.03905 (rank : 416)
Query Neighborhood Hits	531	Target Neighborhood Hits	344	Shared Neighborhood Hits	81
SwissProt Accessions	Q61818, Q6ZPH7, Q8CEV1	Gene names	Rai1, Kiaa1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

ATX2_HUMAN
NC score	0.084719 (rank : 428)	θ value	1.06291 (rank : 279)
Query Neighborhood Hits	531	Target Neighborhood Hits	375	Shared Neighborhood Hits	97
SwissProt Accessions	Q99700, Q6ZQZ7, Q99493	Gene names	ATXN2, ATX2, SCA2, TNRC13
Domain Architecture	No domain graphic available
Description	Ataxin-2 (Spinocerebellar ataxia type 2 protein) (Trinucleotide repeat-containing gene 13 protein).

CD2AP_HUMAN
NC score	0.084559 (rank : 429)	θ value	θ > 10 (rank : 596)
Query Neighborhood Hits	531	Target Neighborhood Hits	315	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

RPB1_MOUSE
NC score	0.084289 (rank : 430)	θ value	0.365318 (rank : 222)
Query Neighborhood Hits	531	Target Neighborhood Hits	363	Shared Neighborhood Hits	68
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

CIZ1_HUMAN
NC score	0.084239 (rank : 431)	θ value	θ > 10 (rank : 603)
Query Neighborhood Hits	531	Target Neighborhood Hits	359	Shared Neighborhood Hits	82
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

MAP4_MOUSE
NC score	0.084024 (rank : 432)	θ value	θ > 10 (rank : 802)
Query Neighborhood Hits	531	Target Neighborhood Hits	409	Shared Neighborhood Hits	87
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

K1683_HUMAN
NC score	0.083925 (rank : 433)	θ value	θ > 10 (rank : 774)
Query Neighborhood Hits	531	Target Neighborhood Hits	240	Shared Neighborhood Hits	71
SwissProt Accessions	Q9H0B3, Q8N4G8, Q96M14, Q9C0I0	Gene names	KIAA1683
Domain Architecture	No domain graphic available
Description	Protein KIAA1683.

ITSN1_HUMAN
NC score	0.083815 (rank : 434)	θ value	θ > 10 (rank : 760)
Query Neighborhood Hits	531	Target Neighborhood Hits	1757	Shared Neighborhood Hits	169
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

RPB1_HUMAN
NC score	0.083755 (rank : 435)	θ value	0.365318 (rank : 221)
Query Neighborhood Hits	531	Target Neighborhood Hits	362	Shared Neighborhood Hits	69
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RAI1_HUMAN
NC score	0.083664 (rank : 436)	θ value	1.06291 (rank : 290)
Query Neighborhood Hits	531	Target Neighborhood Hits	360	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

SPEG_MOUSE
NC score	0.083660 (rank : 437)	θ value	0.00020696 (rank : 27)
Query Neighborhood Hits	531	Target Neighborhood Hits	1959	Shared Neighborhood Hits	246
SwissProt Accessions	Q62407, Q3TPH8, Q6P5V1, Q80TF7, Q80ZN0, Q8BZF4, Q9EQJ5	Gene names	Speg, Apeg1, Kiaa1297
Domain Architecture
Description	Striated muscle-specific serine/threonine protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

DMRTD_HUMAN
NC score	0.083525 (rank : 438)	θ value	θ > 10 (rank : 644)
Query Neighborhood Hits	531	Target Neighborhood Hits	216	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IXT2, Q8N6Q2, Q96M39, Q96SD4	Gene names	DMRTC2
Domain Architecture	No domain graphic available
Description	Doublesex- and mab-3-related transcription factor C2.

ENL_HUMAN
NC score	0.083158 (rank : 439)	θ value	4.03905 (rank : 398)
Query Neighborhood Hits	531	Target Neighborhood Hits	305	Shared Neighborhood Hits	60
SwissProt Accessions	Q03111, Q14768	Gene names	MLLT1, ENL, LTG19, YEATS1
Domain Architecture
Description	Protein ENL (YEATS domain-containing protein 1).

BAT3_MOUSE
NC score	0.083008 (rank : 440)	θ value	θ > 10 (rank : 577)
Query Neighborhood Hits	531	Target Neighborhood Hits	518	Shared Neighborhood Hits	116
SwissProt Accessions	Q9Z1R2, Q8SNA3	Gene names	Bat3
Domain Architecture	No domain graphic available
Description	Large proline-rich protein BAT3 (HLA-B-associated transcript 3).

SPRR3_HUMAN
NC score	0.082835 (rank : 441)	θ value	θ > 10 (rank : 977)
Query Neighborhood Hits	531	Target Neighborhood Hits	102	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UBC9, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3	Gene names	SPRR3, SPRC
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta) (Esophagin) (22 kDa pancornulin).

FMNL_MOUSE
NC score	0.082598 (rank : 442)	θ value	θ > 10 (rank : 716)
Query Neighborhood Hits	531	Target Neighborhood Hits	428	Shared Neighborhood Hits	73
SwissProt Accessions	Q9JL26, Q6KAN4, Q9Z2V7	Gene names	Fmnl1, Frl
Domain Architecture	No domain graphic available
Description	Formin-like protein 1 (Formin-related protein).

CRSP7_HUMAN
NC score	0.082456 (rank : 443)	θ value	2.36792 (rank : 339)
Query Neighborhood Hits	531	Target Neighborhood Hits	247	Shared Neighborhood Hits	67
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

ENAM_MOUSE
NC score	0.082444 (rank : 444)	θ value	θ > 10 (rank : 656)
Query Neighborhood Hits	531	Target Neighborhood Hits	229	Shared Neighborhood Hits	85
SwissProt Accessions	O55196	Gene names	Enam
Domain Architecture	No domain graphic available
Description	Enamelin precursor.

SPN90_HUMAN
NC score	0.082311 (rank : 445)	θ value	θ > 10 (rank : 973)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

NELFA_MOUSE
NC score	0.082254 (rank : 446)	θ value	0.813845 (rank : 266)
Query Neighborhood Hits	531	Target Neighborhood Hits	195	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9	Gene names	Whsc2, Nelfa, Whsc2h
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2).

STAM2_HUMAN
NC score	0.082234 (rank : 447)	θ value	θ > 10 (rank : 994)
Query Neighborhood Hits	531	Target Neighborhood Hits	288	Shared Neighborhood Hits	59
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ABI3_HUMAN
NC score	0.082080 (rank : 448)	θ value	θ > 10 (rank : 539)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	72
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

SETBP_HUMAN
NC score	0.081979 (rank : 449)	θ value	5.27518 (rank : 451)
Query Neighborhood Hits	531	Target Neighborhood Hits	305	Shared Neighborhood Hits	76
SwissProt Accessions	Q9Y6X0, Q9UEF3	Gene names	SETBP1, KIAA0437
Domain Architecture	No domain graphic available
Description	SET-binding protein (SEB).

IF4G1_MOUSE
NC score	0.081930 (rank : 450)	θ value	θ > 10 (rank : 746)
Query Neighborhood Hits	531	Target Neighborhood Hits	534	Shared Neighborhood Hits	140
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

SRBS1_HUMAN
NC score	0.081762 (rank : 451)	θ value	θ > 10 (rank : 981)
Query Neighborhood Hits	531	Target Neighborhood Hits	396	Shared Neighborhood Hits	81
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ITSN1_MOUSE
NC score	0.081733 (rank : 452)	θ value	θ > 10 (rank : 761)
Query Neighborhood Hits	531	Target Neighborhood Hits	1669	Shared Neighborhood Hits	153
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

MILK1_HUMAN
NC score	0.081626 (rank : 453)	θ value	0.62314 (rank : 249)
Query Neighborhood Hits	531	Target Neighborhood Hits	427	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

ZIMP7_HUMAN
NC score	0.081596 (rank : 454)	θ value	θ > 10 (rank : 1059)
Query Neighborhood Hits	531	Target Neighborhood Hits	290	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NF64, O94790, Q659A8, Q6JKL5, Q8WTX8, Q96Q01, Q9BQH7	Gene names	ZIMP7, KIAA1886
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

STAM2_MOUSE
NC score	0.081558 (rank : 455)	θ value	θ > 10 (rank : 995)
Query Neighborhood Hits	531	Target Neighborhood Hits	285	Shared Neighborhood Hits	56
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

KI67_HUMAN
NC score	0.081500 (rank : 456)	θ value	θ > 10 (rank : 775)
Query Neighborhood Hits	531	Target Neighborhood Hits	581	Shared Neighborhood Hits	84
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

OSTF1_HUMAN
NC score	0.081468 (rank : 457)	θ value	θ > 10 (rank : 855)
Query Neighborhood Hits	531	Target Neighborhood Hits	466	Shared Neighborhood Hits	53
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SPN90_MOUSE
NC score	0.081040 (rank : 458)	θ value	θ > 10 (rank : 974)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	46
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

STAM1_MOUSE
NC score	0.081036 (rank : 459)	θ value	θ > 10 (rank : 993)
Query Neighborhood Hits	531	Target Neighborhood Hits	273	Shared Neighborhood Hits	59
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

EPN3_MOUSE
NC score	0.081023 (rank : 460)	θ value	θ > 10 (rank : 684)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	102
SwissProt Accessions	Q91W69, Q9CV55	Gene names	Epn3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

DOT1L_HUMAN
NC score	0.080823 (rank : 461)	θ value	6.88961 (rank : 471)
Query Neighborhood Hits	531	Target Neighborhood Hits	660	Shared Neighborhood Hits	108
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

ABI2_MOUSE
NC score	0.080338 (rank : 462)	θ value	θ > 10 (rank : 538)
Query Neighborhood Hits	531	Target Neighborhood Hits	266	Shared Neighborhood Hits	61
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CO039_HUMAN
NC score	0.080284 (rank : 463)	θ value	θ > 10 (rank : 613)
Query Neighborhood Hits	531	Target Neighborhood Hits	264	Shared Neighborhood Hits	84
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

EFS_HUMAN
NC score	0.080199 (rank : 464)	θ value	θ > 10 (rank : 649)
Query Neighborhood Hits	531	Target Neighborhood Hits	348	Shared Neighborhood Hits	96
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

SOCS1_MOUSE
NC score	0.079979 (rank : 465)	θ value	θ > 10 (rank : 961)
Query Neighborhood Hits	531	Target Neighborhood Hits	82	Shared Neighborhood Hits	33
SwissProt Accessions	O35716, O35960, Q3U3L0	Gene names	Socs1, Cish1, Ssi1
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1).

GPS2_HUMAN
NC score	0.079957 (rank : 466)	θ value	θ > 10 (rank : 724)
Query Neighborhood Hits	531	Target Neighborhood Hits	459	Shared Neighborhood Hits	76
SwissProt Accessions	Q13227	Gene names	GPS2
Domain Architecture	No domain graphic available
Description	G protein pathway suppressor 2 (Protein GPS2).

SMR1_MOUSE
NC score	0.079393 (rank : 467)	θ value	6.88961 (rank : 489)
Query Neighborhood Hits	531	Target Neighborhood Hits	103	Shared Neighborhood Hits	44
SwissProt Accessions	Q61900	Gene names	Smr1, Msg1
Domain Architecture	No domain graphic available
Description	Submaxillary gland androgen-regulated protein 1 precursor (Salivary protein MSG1).

BAZ2A_HUMAN
NC score	0.079145 (rank : 468)	θ value	6.88961 (rank : 466)
Query Neighborhood Hits	531	Target Neighborhood Hits	780	Shared Neighborhood Hits	141
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

PER2_MOUSE
NC score	0.078975 (rank : 469)	θ value	θ > 10 (rank : 868)
Query Neighborhood Hits	531	Target Neighborhood Hits	325	Shared Neighborhood Hits	98
SwissProt Accessions	O54943, O54954	Gene names	Per2
Domain Architecture
Description	Period circadian protein 2 (mPER2).

CT151_HUMAN
NC score	0.078964 (rank : 470)	θ value	3.0926 (rank : 366)
Query Neighborhood Hits	531	Target Neighborhood Hits	382	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NC74, Q8N4Z9, Q9BR75, Q9H0Y9	Gene names	C20orf151
Domain Architecture
Description	Uncharacterized protein C20orf151.

IF4B_HUMAN
NC score	0.078847 (rank : 471)	θ value	θ > 10 (rank : 744)
Query Neighborhood Hits	531	Target Neighborhood Hits	417	Shared Neighborhood Hits	90
SwissProt Accessions	P23588	Gene names	EIF4B
Domain Architecture
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

SYN1_MOUSE
NC score	0.078781 (rank : 472)	θ value	θ > 10 (rank : 999)
Query Neighborhood Hits	531	Target Neighborhood Hits	363	Shared Neighborhood Hits	96
SwissProt Accessions	O88935, Q62279, Q8QZT8	Gene names	Syn1, Syn-1
Domain Architecture
Description	Synapsin-1 (Synapsin I).

CD248_MOUSE
NC score	0.078698 (rank : 473)	θ value	θ > 10 (rank : 595)
Query Neighborhood Hits	531	Target Neighborhood Hits	578	Shared Neighborhood Hits	128
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

PDC6I_HUMAN
NC score	0.078659 (rank : 474)	θ value	4.03905 (rank : 412)
Query Neighborhood Hits	531	Target Neighborhood Hits	278	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WUM4, Q9BX86, Q9NUN0, Q9P2H2, Q9UKL5	Gene names	PDCD6IP, AIP1, ALIX, KIAA1375
Domain Architecture
Description	Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (Hp95).

CJ012_HUMAN
NC score	0.078658 (rank : 475)	θ value	θ > 10 (rank : 604)
Query Neighborhood Hits	531	Target Neighborhood Hits	467	Shared Neighborhood Hits	89
SwissProt Accessions	Q8N655, Q9H945, Q9Y457	Gene names	C10orf12
Domain Architecture	No domain graphic available
Description	Protein C10orf12.

GAK10_HUMAN
NC score	0.078655 (rank : 476)	θ value	θ > 10 (rank : 721)
Query Neighborhood Hits	531	Target Neighborhood Hits	289	Shared Neighborhood Hits	120
SwissProt Accessions	P87889, P10263, P10264, Q69385, Q9UKH6	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_5q33.3 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K10 Gag protein) (HERV-K107 Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

ARHG7_MOUSE
NC score	0.078462 (rank : 477)	θ value	θ > 10 (rank : 568)
Query Neighborhood Hits	531	Target Neighborhood Hits	396	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

IL3B2_MOUSE
NC score	0.078339 (rank : 478)	θ value	θ > 10 (rank : 749)
Query Neighborhood Hits	531	Target Neighborhood Hits	372	Shared Neighborhood Hits	117
SwissProt Accessions	P26954	Gene names	Csf2rb2, Ai2ca, Il3r, Il3rb2
Domain Architecture
Description	Interleukin-3 receptor class 2 beta chain precursor (Interleukin-3 receptor class II beta chain) (Colony-stimulating factor 2 receptor, beta 2 chain).

ACINU_HUMAN
NC score	0.078201 (rank : 479)	θ value	θ > 10 (rank : 544)
Query Neighborhood Hits	531	Target Neighborhood Hits	828	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UKV3, O75158, Q9UG91, Q9UKV1, Q9UKV2	Gene names	ACIN1, ACINUS, KIAA0670
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

OSTF1_MOUSE
NC score	0.078080 (rank : 480)	θ value	θ > 10 (rank : 856)
Query Neighborhood Hits	531	Target Neighborhood Hits	467	Shared Neighborhood Hits	52
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

SFRIP_HUMAN
NC score	0.078044 (rank : 481)	θ value	θ > 10 (rank : 934)
Query Neighborhood Hits	531	Target Neighborhood Hits	530	Shared Neighborhood Hits	86
SwissProt Accessions	Q99590, Q8IW59	Gene names	SFRS2IP, CASP11, SIP1
Domain Architecture	No domain graphic available
Description	SFRS2-interacting protein (Splicing factor, arginine/serine-rich 2- interacting protein) (SC35-interacting protein 1) (CTD-associated SR protein 11) (Splicing regulatory protein 129) (SRrp129) (NY-REN-40 antigen).

STAM1_HUMAN
NC score	0.077919 (rank : 482)	θ value	θ > 10 (rank : 992)
Query Neighborhood Hits	531	Target Neighborhood Hits	271	Shared Neighborhood Hits	57
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

IF4B_MOUSE
NC score	0.077859 (rank : 483)	θ value	θ > 10 (rank : 745)
Query Neighborhood Hits	531	Target Neighborhood Hits	368	Shared Neighborhood Hits	90
SwissProt Accessions	Q8BGD9, Q3TD64	Gene names	Eif4b
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4B (eIF-4B).

SHAN2_MOUSE
NC score	0.077857 (rank : 484)	θ value	θ > 10 (rank : 947)
Query Neighborhood Hits	531	Target Neighborhood Hits	446	Shared Neighborhood Hits	77
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

HNRL1_HUMAN
NC score	0.077812 (rank : 485)	θ value	0.163984 (rank : 161)
Query Neighborhood Hits	531	Target Neighborhood Hits	173	Shared Neighborhood Hits	43
SwissProt Accessions	Q9BUJ2, O76022, Q6ZSZ0, Q7L8P4, Q8N6Z4, Q96G37, Q9HAL3, Q9UG75	Gene names	HNRPUL1, E1BAP5
Domain Architecture	No domain graphic available
Description	Heterogeneous nuclear ribonucleoprotein U-like protein 1 (Adenovirus early region 1B-associated protein 5) (E1B-55 kDa-associated protein 5) (E1B-AP5).

SNIP_MOUSE
NC score	0.077376 (rank : 486)	θ value	0.21417 (rank : 182)
Query Neighborhood Hits	531	Target Neighborhood Hits	319	Shared Neighborhood Hits	53
SwissProt Accessions	Q9QWI6, O70298	Gene names	P140, Kiaa1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

ARHG7_HUMAN
NC score	0.077206 (rank : 487)	θ value	θ > 10 (rank : 567)
Query Neighborhood Hits	531	Target Neighborhood Hits	347	Shared Neighborhood Hits	54
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

SOCS1_HUMAN
NC score	0.077123 (rank : 488)	θ value	θ > 10 (rank : 960)
Query Neighborhood Hits	531	Target Neighborhood Hits	79	Shared Neighborhood Hits	34
SwissProt Accessions	O15524, O15097, Q9NSA7	Gene names	SOCS1, SSI1, TIP3
Domain Architecture
Description	Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3).

DCP1A_HUMAN
NC score	0.076936 (rank : 489)	θ value	θ > 10 (rank : 634)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	78
SwissProt Accessions	Q9NPI6	Gene names	DCP1A, SMIF
Domain Architecture	No domain graphic available
Description	mRNA decapping enzyme 1A (EC 3.-.-.-) (Transcription factor SMIF) (Smad4-interacting transcriptional co-activator).

MEGF9_MOUSE
NC score	0.076927 (rank : 490)	θ value	θ > 10 (rank : 810)
Query Neighborhood Hits	531	Target Neighborhood Hits	896	Shared Neighborhood Hits	167
SwissProt Accessions	Q8BH27, Q8BWI4	Gene names	Megf9, Egfl5, Kiaa0818
Domain Architecture
Description	Multiple epidermal growth factor-like domains 9 precursor (EGF-like domain-containing protein 5) (Multiple EGF-like domain protein 5).

PYGO2_HUMAN
NC score	0.076376 (rank : 491)	θ value	θ > 10 (rank : 897)
Query Neighborhood Hits	531	Target Neighborhood Hits	189	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BRQ0, Q8WYZ4, Q96CY2	Gene names	PYGO2
Domain Architecture
Description	Pygopus homolog 2.

ACINU_MOUSE
NC score	0.076147 (rank : 492)	θ value	0.365318 (rank : 212)
Query Neighborhood Hits	531	Target Neighborhood Hits	712	Shared Neighborhood Hits	77
SwissProt Accessions	Q9JIX8, Q9CSN7, Q9CSR9, Q9CSX7, Q9R046, Q9R047	Gene names	Acin1, Acinus
Domain Architecture
Description	Apoptotic chromatin condensation inducer in the nucleus (Acinus).

MYO15_HUMAN
NC score	0.076060 (rank : 493)	θ value	0.813845 (rank : 264)
Query Neighborhood Hits	531	Target Neighborhood Hits	671	Shared Neighborhood Hits	201
SwissProt Accessions	Q9UKN7	Gene names	MYO15A, MYO15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

MAST4_HUMAN
NC score	0.075975 (rank : 494)	θ value	0.62314 (rank : 247)
Query Neighborhood Hits	531	Target Neighborhood Hits	1804	Shared Neighborhood Hits	251
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ES8L3_HUMAN
NC score	0.075671 (rank : 495)	θ value	θ > 10 (rank : 694)
Query Neighborhood Hits	531	Target Neighborhood Hits	206	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ABI1_HUMAN
NC score	0.075551 (rank : 496)	θ value	5.27518 (rank : 425)
Query Neighborhood Hits	531	Target Neighborhood Hits	257	Shared Neighborhood Hits	68
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ARI5B_HUMAN
NC score	0.075425 (rank : 497)	θ value	0.0736092 (rank : 127)
Query Neighborhood Hits	531	Target Neighborhood Hits	328	Shared Neighborhood Hits	53
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

K1688_HUMAN
NC score	0.075298 (rank : 498)	θ value	1.38821 (rank : 301)
Query Neighborhood Hits	531	Target Neighborhood Hits	217	Shared Neighborhood Hits	57
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

PELP1_HUMAN
NC score	0.075296 (rank : 499)	θ value	θ > 10 (rank : 866)
Query Neighborhood Hits	531	Target Neighborhood Hits	596	Shared Neighborhood Hits	87
SwissProt Accessions	Q8IZL8, O15450, Q5EGN3, Q6NTE6, Q96FT1, Q9BU60	Gene names	PELP1, HMX3, MNAR
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor) (Transcription factor HMX3).

VINEX_MOUSE
NC score	0.075185 (rank : 500)	θ value	θ > 10 (rank : 1052)
Query Neighborhood Hits	531	Target Neighborhood Hits	286	Shared Neighborhood Hits	59
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

STAC3_HUMAN
NC score	0.075086 (rank : 501)	θ value	θ > 10 (rank : 988)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	41
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ENAM_HUMAN
NC score	0.074860 (rank : 502)	θ value	θ > 10 (rank : 655)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NRM1, Q9H3D1	Gene names	ENAM
Domain Architecture
Description	Enamelin precursor.

AFF4_MOUSE
NC score	0.074833 (rank : 503)	θ value	5.27518 (rank : 426)
Query Neighborhood Hits	531	Target Neighborhood Hits	581	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESC8, Q8C6K4, Q8C6W3, Q8CCH3	Gene names	Aff4, Alf4
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4.

FES_HUMAN
NC score	0.074781 (rank : 504)	θ value	θ > 10 (rank : 702)
Query Neighborhood Hits	531	Target Neighborhood Hits	978	Shared Neighborhood Hits	77
SwissProt Accessions	P07332	Gene names	FES, FPS
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

STAC3_MOUSE
NC score	0.074766 (rank : 505)	θ value	θ > 10 (rank : 989)
Query Neighborhood Hits	531	Target Neighborhood Hits	232	Shared Neighborhood Hits	43
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

GCX1_HUMAN
NC score	0.074693 (rank : 506)	θ value	0.0193708 (rank : 90)
Query Neighborhood Hits	531	Target Neighborhood Hits	132	Shared Neighborhood Hits	24
SwissProt Accessions	Q96NM4, Q5TE33, Q5TE34, Q5TE35, Q96IC9, Q9BQN5	Gene names	GCX1, C20orf100
Domain Architecture
Description	Granulosa cell HMG box protein 1 (GCX-1).

AMELX_HUMAN
NC score	0.074399 (rank : 507)	θ value	0.47712 (rank : 228)
Query Neighborhood Hits	531	Target Neighborhood Hits	95	Shared Neighborhood Hits	34
SwissProt Accessions	Q99217, Q96NW6, Q9UCA7	Gene names	AMELX, AMG, AMGX
Domain Architecture
Description	Amelogenin, X isoform precursor.

CG1_HUMAN
NC score	0.074347 (rank : 508)	θ value	θ > 10 (rank : 598)
Query Neighborhood Hits	531	Target Neighborhood Hits	222	Shared Neighborhood Hits	68
SwissProt Accessions	Q13495	Gene names	CXorf6, CG1
Domain Architecture	No domain graphic available
Description	CG1 protein (F18).

ABI3_MOUSE
NC score	0.074343 (rank : 509)	θ value	θ > 10 (rank : 540)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

IL3RB_MOUSE
NC score	0.074332 (rank : 510)	θ value	θ > 10 (rank : 750)
Query Neighborhood Hits	531	Target Neighborhood Hits	355	Shared Neighborhood Hits	114
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

PRAX_HUMAN
NC score	0.073996 (rank : 511)	θ value	θ > 10 (rank : 885)
Query Neighborhood Hits	531	Target Neighborhood Hits	215	Shared Neighborhood Hits	53
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

3BP2_MOUSE
NC score	0.073829 (rank : 512)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	531	Target Neighborhood Hits	142	Shared Neighborhood Hits	40
SwissProt Accessions	Q06649	Gene names	Sh3bp2, 3bp2
Domain Architecture
Description	SH3 domain-binding protein 2 (3BP-2).

CASC3_MOUSE
NC score	0.073734 (rank : 513)	θ value	θ > 10 (rank : 590)
Query Neighborhood Hits	531	Target Neighborhood Hits	333	Shared Neighborhood Hits	90
SwissProt Accessions	Q8K3W3, Q8K219, Q99NF0	Gene names	Casc3, Mln51
Domain Architecture	No domain graphic available
Description	Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (Protein MLN 51 homolog) (Protein barentsz) (Btz).

GRIN1_MOUSE
NC score	0.073715 (rank : 514)	θ value	θ > 10 (rank : 733)
Query Neighborhood Hits	531	Target Neighborhood Hits	337	Shared Neighborhood Hits	84
SwissProt Accessions	Q3UNH4, Q6PGF9, Q9QZY2	Gene names	Gprin1
Domain Architecture	No domain graphic available
Description	G protein-regulated inducer of neurite outgrowth 1 (GRIN1).

TXND2_MOUSE
NC score	0.073573 (rank : 515)	θ value	θ > 10 (rank : 1030)
Query Neighborhood Hits	531	Target Neighborhood Hits	828	Shared Neighborhood Hits	91
SwissProt Accessions	Q6P902, Q8CJD1	Gene names	Txndc2, Sptrx, Sptrx1, Trx4
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1) (Thioredoxin-4).

3BP1_HUMAN
NC score	0.073557 (rank : 516)	θ value	0.0252991 (rank : 95)
Query Neighborhood Hits	531	Target Neighborhood Hits	376	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CSKI2_HUMAN
NC score	0.073523 (rank : 517)	θ value	0.0252991 (rank : 99)
Query Neighborhood Hits	531	Target Neighborhood Hits	747	Shared Neighborhood Hits	96
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

LIPS_HUMAN
NC score	0.073490 (rank : 518)	θ value	θ > 10 (rank : 789)
Query Neighborhood Hits	531	Target Neighborhood Hits	314	Shared Neighborhood Hits	93
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

VINEX_HUMAN
NC score	0.073479 (rank : 519)	θ value	θ > 10 (rank : 1051)
Query Neighborhood Hits	531	Target Neighborhood Hits	270	Shared Neighborhood Hits	56
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

CAC1G_HUMAN
NC score	0.073437 (rank : 520)	θ value	8.99809 (rank : 506)
Query Neighborhood Hits	531	Target Neighborhood Hits	587	Shared Neighborhood Hits	157
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

LARP4_MOUSE
NC score	0.073058 (rank : 521)	θ value	θ > 10 (rank : 783)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	77
SwissProt Accessions	Q8BWW4, Q3UR69	Gene names	Larp4
Domain Architecture	No domain graphic available
Description	La-related protein 4 (La ribonucleoprotein domain family member 4).

PI5PA_MOUSE
NC score	0.072984 (rank : 522)	θ value	θ > 10 (rank : 877)
Query Neighborhood Hits	531	Target Neighborhood Hits	331	Shared Neighborhood Hits	92
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

AFF4_HUMAN
NC score	0.072860 (rank : 523)	θ value	4.03905 (rank : 389)
Query Neighborhood Hits	531	Target Neighborhood Hits	611	Shared Neighborhood Hits	82
SwissProt Accessions	Q9UHB7, Q498B2, Q59FB3, Q6P592, Q8TDR1, Q9P0E4	Gene names	AFF4, AF5Q31, MCEF
Domain Architecture	No domain graphic available
Description	AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31) (Major CDK9 elongation factor-associated protein).

DNMBP_MOUSE
NC score	0.072859 (rank : 524)	θ value	θ > 10 (rank : 646)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	90
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

RBBP6_MOUSE
NC score	0.072726 (rank : 525)	θ value	θ > 10 (rank : 901)
Query Neighborhood Hits	531	Target Neighborhood Hits	1014	Shared Neighborhood Hits	123
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

MAP1B_MOUSE
NC score	0.072688 (rank : 526)	θ value	5.27518 (rank : 442)
Query Neighborhood Hits	531	Target Neighborhood Hits	977	Shared Neighborhood Hits	112
SwissProt Accessions	P14873	Gene names	Map1b, Mtap1b, Mtap5
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) (MAP1.2) (MAP1(X)) [Contains: MAP1 light chain LC1].

AFF2_MOUSE
NC score	0.072660 (rank : 527)	θ value	8.99809 (rank : 500)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	69
SwissProt Accessions	O55112	Gene names	Aff2, Fmr2, Ox19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation protein 2 homolog) (Protein FMR-2) (FMR2P) (Protein Ox19).

PDZD2_HUMAN
NC score	0.072615 (rank : 528)	θ value	θ > 10 (rank : 865)
Query Neighborhood Hits	531	Target Neighborhood Hits	772	Shared Neighborhood Hits	133
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

TEX14_HUMAN
NC score	0.072561 (rank : 529)	θ value	θ > 10 (rank : 1014)
Query Neighborhood Hits	531	Target Neighborhood Hits	1103	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

SETD2_HUMAN
NC score	0.072547 (rank : 530)	θ value	θ > 10 (rank : 926)
Query Neighborhood Hits	531	Target Neighborhood Hits	412	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

MAVS_HUMAN
NC score	0.072225 (rank : 531)	θ value	θ > 10 (rank : 805)
Query Neighborhood Hits	531	Target Neighborhood Hits	271	Shared Neighborhood Hits	78
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

NCF1_MOUSE
NC score	0.072014 (rank : 532)	θ value	θ > 10 (rank : 830)
Query Neighborhood Hits	531	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

G3BP2_HUMAN
NC score	0.071844 (rank : 533)	θ value	0.0431538 (rank : 113)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

G3BP2_MOUSE
NC score	0.071674 (rank : 534)	θ value	0.0961366 (rank : 142)
Query Neighborhood Hits	531	Target Neighborhood Hits	258	Shared Neighborhood Hits	38
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

PPIP1_HUMAN
NC score	0.071504 (rank : 535)	θ value	θ > 10 (rank : 882)
Query Neighborhood Hits	531	Target Neighborhood Hits	389	Shared Neighborhood Hits	57
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

SF01_HUMAN
NC score	0.071298 (rank : 536)	θ value	θ > 10 (rank : 928)
Query Neighborhood Hits	531	Target Neighborhood Hits	287	Shared Neighborhood Hits	76
SwissProt Accessions	Q15637, Q14818, Q14819, Q15913, Q8IY00, Q92744, Q92745, Q969H7, Q9BW01, Q9UEI0	Gene names	SF1, ZFM1, ZNF162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (Zinc finger gene in MEN1 locus) (Mammalian branch point-binding protein mBBP) (BBP).

GAK1_HUMAN
NC score	0.071127 (rank : 537)	θ value	5.27518 (rank : 438)
Query Neighborhood Hits	531	Target Neighborhood Hits	268	Shared Neighborhood Hits	111
SwissProt Accessions	P62683	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_12q14.1 provirus ancestral Gag polyprotein (Gag polyprotein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

CSKI2_MOUSE
NC score	0.070703 (rank : 538)	θ value	θ > 10 (rank : 623)
Query Neighborhood Hits	531	Target Neighborhood Hits	812	Shared Neighborhood Hits	123
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

PRAX_MOUSE
NC score	0.070679 (rank : 539)	θ value	θ > 10 (rank : 886)
Query Neighborhood Hits	531	Target Neighborhood Hits	199	Shared Neighborhood Hits	52
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

ZC313_HUMAN
NC score	0.070674 (rank : 540)	θ value	0.21417 (rank : 188)
Query Neighborhood Hits	531	Target Neighborhood Hits	772	Shared Neighborhood Hits	64
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

BIN1_HUMAN
NC score	0.070647 (rank : 541)	θ value	3.0926 (rank : 363)
Query Neighborhood Hits	531	Target Neighborhood Hits	335	Shared Neighborhood Hits	69
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SMRC2_MOUSE
NC score	0.070563 (rank : 542)	θ value	1.38821 (rank : 309)
Query Neighborhood Hits	531	Target Neighborhood Hits	487	Shared Neighborhood Hits	90
SwissProt Accessions	Q6PDG5, Q6P6P3	Gene names	Smarcc2, Baf170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

FES_MOUSE
NC score	0.070444 (rank : 543)	θ value	θ > 10 (rank : 703)
Query Neighborhood Hits	531	Target Neighborhood Hits	980	Shared Neighborhood Hits	76
SwissProt Accessions	P16879, Q62122	Gene names	Fes, Fps
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (C-Fes).

PACN2_MOUSE
NC score	0.070425 (rank : 544)	θ value	θ > 10 (rank : 860)
Query Neighborhood Hits	531	Target Neighborhood Hits	382	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PPIP1_MOUSE
NC score	0.070282 (rank : 545)	θ value	θ > 10 (rank : 883)
Query Neighborhood Hits	531	Target Neighborhood Hits	377	Shared Neighborhood Hits	58
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

AHI1_HUMAN
NC score	0.070277 (rank : 546)	θ value	θ > 10 (rank : 547)
Query Neighborhood Hits	531	Target Neighborhood Hits	537	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

RTN4_HUMAN
NC score	0.070156 (rank : 547)	θ value	8.99809 (rank : 522)
Query Neighborhood Hits	531	Target Neighborhood Hits	357	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

ULK1_MOUSE
NC score	0.070150 (rank : 548)	θ value	2.36792 (rank : 356)
Query Neighborhood Hits	531	Target Neighborhood Hits	1214	Shared Neighborhood Hits	190
SwissProt Accessions	O70405, Q6PGB2	Gene names	Ulk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1).

TCOF_HUMAN
NC score	0.070085 (rank : 549)	θ value	θ > 10 (rank : 1011)
Query Neighborhood Hits	531	Target Neighborhood Hits	543	Shared Neighborhood Hits	81
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

STAC_MOUSE
NC score	0.069799 (rank : 550)	θ value	θ > 10 (rank : 991)
Query Neighborhood Hits	531	Target Neighborhood Hits	268	Shared Neighborhood Hits	49
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

JIP1_MOUSE
NC score	0.069576 (rank : 551)	θ value	θ > 10 (rank : 769)
Query Neighborhood Hits	531	Target Neighborhood Hits	259	Shared Neighborhood Hits	82
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

NRX2A_HUMAN
NC score	0.069523 (rank : 552)	θ value	θ > 10 (rank : 842)
Query Neighborhood Hits	531	Target Neighborhood Hits	614	Shared Neighborhood Hits	149
SwissProt Accessions	Q9P2S2, Q9Y2D6	Gene names	NRXN2, KIAA0921
Domain Architecture
Description	Neurexin-2-alpha precursor (Neurexin II-alpha).

SGIP1_MOUSE
NC score	0.069478 (rank : 553)	θ value	θ > 10 (rank : 935)
Query Neighborhood Hits	531	Target Neighborhood Hits	180	Shared Neighborhood Hits	49
SwissProt Accessions	Q8VD37, Q3UFU3, Q3UGA0, Q8BXX4, Q8C034, Q9CXT2	Gene names	Sgip1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

DNMBP_HUMAN
NC score	0.069385 (rank : 554)	θ value	θ > 10 (rank : 645)
Query Neighborhood Hits	531	Target Neighborhood Hits	413	Shared Neighborhood Hits	70
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GON4L_MOUSE
NC score	0.069284 (rank : 555)	θ value	θ > 10 (rank : 723)
Query Neighborhood Hits	531	Target Neighborhood Hits	455	Shared Neighborhood Hits	97
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

SOCS5_HUMAN
NC score	0.069244 (rank : 556)	θ value	θ > 10 (rank : 966)
Query Neighborhood Hits	531	Target Neighborhood Hits	91	Shared Neighborhood Hits	41
SwissProt Accessions	O75159, Q8IYZ4	Gene names	SOCS5, CIS6, CISH5, CISH6, KIAA0671
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5) (Cytokine-inducible SH2 protein 6) (CIS-6).

ENAH_HUMAN
NC score	0.069108 (rank : 557)	θ value	1.38821 (rank : 300)
Query Neighborhood Hits	531	Target Neighborhood Hits	784	Shared Neighborhood Hits	101
SwissProt Accessions	Q8N8S7, Q502W5, Q5T5M7, Q5VTQ9, Q5VTR0, Q9NVF3, Q9UFB8	Gene names	ENAH, MENA
Domain Architecture
Description	Protein enabled homolog.

AATK_MOUSE
NC score	0.069092 (rank : 558)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	531	Target Neighborhood Hits	942	Shared Neighborhood Hits	83
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

NFRKB_MOUSE
NC score	0.069087 (rank : 559)	θ value	θ > 10 (rank : 836)
Query Neighborhood Hits	531	Target Neighborhood Hits	393	Shared Neighborhood Hits	93
SwissProt Accessions	Q6PIJ4, Q8BWV5, Q8K0X6	Gene names	Nfrkb
Domain Architecture	No domain graphic available
Description	Nuclear factor related to kappa-B-binding protein (DNA-binding protein R kappa-B).

SOX30_MOUSE
NC score	0.069084 (rank : 560)	θ value	4.03905 (rank : 420)
Query Neighborhood Hits	531	Target Neighborhood Hits	374	Shared Neighborhood Hits	115
SwissProt Accessions	Q8CGW4	Gene names	Sox30
Domain Architecture
Description	Transcription factor SOX-30.

AFF2_HUMAN
NC score	0.068917 (rank : 561)	θ value	θ > 10 (rank : 546)
Query Neighborhood Hits	531	Target Neighborhood Hits	218	Shared Neighborhood Hits	59
SwissProt Accessions	P51816, O43786, O60215, P78407, Q13521, Q14323, Q9UNA5	Gene names	AFF2, FMR2, OX19
Domain Architecture
Description	AF4/FMR2 family member 2 (Fragile X mental retardation 2 protein) (Protein FMR-2) (FMR2P) (Protein Ox19) (Fragile X E mental retardation syndrome protein).

DIAP1_MOUSE
NC score	0.068843 (rank : 562)	θ value	θ > 10 (rank : 640)
Query Neighborhood Hits	531	Target Neighborhood Hits	839	Shared Neighborhood Hits	90
SwissProt Accessions	O08808	Gene names	Diaph1, Diap1
Domain Architecture
Description	Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) (mDIA1) (p140mDIA).

M3K11_HUMAN
NC score	0.068787 (rank : 563)	θ value	1.06291 (rank : 284)
Query Neighborhood Hits	531	Target Neighborhood Hits	1136	Shared Neighborhood Hits	110
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

BPTF_HUMAN
NC score	0.068746 (rank : 564)	θ value	θ > 10 (rank : 585)
Query Neighborhood Hits	531	Target Neighborhood Hits	786	Shared Neighborhood Hits	89
SwissProt Accessions	Q12830, Q6NX67, Q7Z7D6, Q9UIG2	Gene names	FALZ, BPTF, FAC1
Domain Architecture
Description	Nucleosome remodeling factor subunit BPTF (Bromodomain and PHD finger- containing transcription factor) (Fetal Alzheimer antigen) (Fetal Alz- 50 clone 1 protein).

NCF1_HUMAN
NC score	0.068684 (rank : 565)	θ value	θ > 10 (rank : 829)
Query Neighborhood Hits	531	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SOCS5_MOUSE
NC score	0.068671 (rank : 566)	θ value	θ > 10 (rank : 967)
Query Neighborhood Hits	531	Target Neighborhood Hits	93	Shared Neighborhood Hits	40
SwissProt Accessions	O54928	Gene names	Socs5, Cish5
Domain Architecture
Description	Suppressor of cytokine signaling 5 (SOCS-5) (Cytokine-inducible SH2- containing protein 5).

SRC8_HUMAN
NC score	0.068338 (rank : 567)	θ value	θ > 10 (rank : 983)
Query Neighborhood Hits	531	Target Neighborhood Hits	269	Shared Neighborhood Hits	51
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

PACN2_HUMAN
NC score	0.068293 (rank : 568)	θ value	θ > 10 (rank : 859)
Query Neighborhood Hits	531	Target Neighborhood Hits	339	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SRC8_MOUSE
NC score	0.068114 (rank : 569)	θ value	θ > 10 (rank : 984)
Query Neighborhood Hits	531	Target Neighborhood Hits	292	Shared Neighborhood Hits	59
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

RBBP6_HUMAN
NC score	0.068017 (rank : 570)	θ value	6.88961 (rank : 485)
Query Neighborhood Hits	531	Target Neighborhood Hits	1135	Shared Neighborhood Hits	127
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

DACT1_HUMAN
NC score	0.067961 (rank : 571)	θ value	θ > 10 (rank : 630)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

GTSE1_HUMAN
NC score	0.067956 (rank : 572)	θ value	θ > 10 (rank : 734)
Query Neighborhood Hits	531	Target Neighborhood Hits	193	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NYZ3, Q53GX5, Q5R3I6, Q6DHX4, Q9BRE0, Q9UGZ9, Q9Y557	Gene names	GTSE1
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (B99 homolog).

ECM1_MOUSE
NC score	0.067949 (rank : 573)	θ value	θ > 10 (rank : 648)
Query Neighborhood Hits	531	Target Neighborhood Hits	105	Shared Neighborhood Hits	47
SwissProt Accessions	Q61508	Gene names	Ecm1
Domain Architecture
Description	Extracellular matrix protein 1 precursor (Secretory component p85).

ZCH14_MOUSE
NC score	0.067738 (rank : 574)	θ value	3.0926 (rank : 387)
Query Neighborhood Hits	531	Target Neighborhood Hits	109	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VIG0, Q80TX3, Q91VU4	Gene names	Zcchc14, Kiaa0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

ABI1_MOUSE
NC score	0.067680 (rank : 575)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	531	Target Neighborhood Hits	246	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

WNK2_HUMAN
NC score	0.067600 (rank : 576)	θ value	θ > 10 (rank : 1057)
Query Neighborhood Hits	531	Target Neighborhood Hits	1407	Shared Neighborhood Hits	193
SwissProt Accessions	Q9Y3S1, Q8IY36, Q9C0A3, Q9H3P4	Gene names	WNK2, KIAA1760, PRKWNK2
Domain Architecture
Description	Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2).

DOK2_MOUSE
NC score	0.067533 (rank : 577)	θ value	θ > 10 (rank : 647)
Query Neighborhood Hits	531	Target Neighborhood Hits	244	Shared Neighborhood Hits	94
SwissProt Accessions	O70469, O70272, Q99KL1	Gene names	Dok2, Frip
Domain Architecture
Description	Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2)) (Dok- related protein) (Dok-R) (IL-four receptor-interacting protein) (FRIP).

NCF2_HUMAN
NC score	0.067490 (rank : 578)	θ value	θ > 10 (rank : 831)
Query Neighborhood Hits	531	Target Neighborhood Hits	229	Shared Neighborhood Hits	43
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

RTN4_MOUSE
NC score	0.067055 (rank : 579)	θ value	1.38821 (rank : 305)
Query Neighborhood Hits	531	Target Neighborhood Hits	341	Shared Neighborhood Hits	73
SwissProt Accessions	Q99P72, Q5DTK9, Q7TNB7, Q80W95, Q8BGK7, Q8BGM9, Q8K290, Q8K3G8, Q9CTE3	Gene names	Rtn4, Kiaa0886, Nogo
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein).

STAC_HUMAN
NC score	0.067049 (rank : 580)	θ value	θ > 10 (rank : 990)
Query Neighborhood Hits	531	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ERBB2_HUMAN
NC score	0.067016 (rank : 581)	θ value	θ > 10 (rank : 685)
Query Neighborhood Hits	531	Target Neighborhood Hits	1073	Shared Neighborhood Hits	109
SwissProt Accessions	P04626, Q14256, Q6LDV1, Q9UMK4	Gene names	ERBB2, HER2, NEU, NGL
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene) (Tyrosine kinase-type cell surface receptor HER2) (MLN 19).

DAB1_MOUSE
NC score	0.066911 (rank : 582)	θ value	1.81305 (rank : 319)
Query Neighborhood Hits	531	Target Neighborhood Hits	145	Shared Neighborhood Hits	48
SwissProt Accessions	P97318, P97316, P97317	Gene names	Dab1
Domain Architecture
Description	Disabled homolog 1.

SF3B1_MOUSE
NC score	0.066882 (rank : 583)	θ value	θ > 10 (rank : 932)
Query Neighborhood Hits	531	Target Neighborhood Hits	352	Shared Neighborhood Hits	78
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

TEX14_MOUSE
NC score	0.066755 (rank : 584)	θ value	θ > 10 (rank : 1015)
Query Neighborhood Hits	531	Target Neighborhood Hits	1333	Shared Neighborhood Hits	98
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

MAP1B_HUMAN
NC score	0.066659 (rank : 585)	θ value	θ > 10 (rank : 801)
Query Neighborhood Hits	531	Target Neighborhood Hits	903	Shared Neighborhood Hits	97
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

SASH1_MOUSE
NC score	0.066639 (rank : 586)	θ value	θ > 10 (rank : 922)
Query Neighborhood Hits	531	Target Neighborhood Hits	263	Shared Neighborhood Hits	57
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

ARHG6_HUMAN
NC score	0.066508 (rank : 587)	θ value	θ > 10 (rank : 565)
Query Neighborhood Hits	531	Target Neighborhood Hits	376	Shared Neighborhood Hits	50
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

AMPH_HUMAN
NC score	0.066481 (rank : 588)	θ value	θ > 10 (rank : 554)
Query Neighborhood Hits	531	Target Neighborhood Hits	455	Shared Neighborhood Hits	95
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ITSN2_HUMAN
NC score	0.066457 (rank : 589)	θ value	θ > 10 (rank : 762)
Query Neighborhood Hits	531	Target Neighborhood Hits	1173	Shared Neighborhood Hits	94
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

PDC6I_MOUSE
NC score	0.066452 (rank : 590)	θ value	θ > 10 (rank : 863)
Query Neighborhood Hits	531	Target Neighborhood Hits	275	Shared Neighborhood Hits	71
SwissProt Accessions	Q9WU78, O88695, O89014, Q8BSL8, Q8R0H5, Q99LR3, Q9QZN8	Gene names	Pdcd6ip, Aip1, Alix
Domain Architecture
Description	Programmed cell death 6-interacting protein (ALG-2-interacting protein X) (ALG-2-interacting protein 1) (E2F1-inducible protein) (Eig2).

EVL_HUMAN
NC score	0.066270 (rank : 591)	θ value	θ > 10 (rank : 696)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UI08, O95884, Q7Z522, Q8TBV1, Q9UF25, Q9UIC2	Gene names	EVL, RNB6
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

CRTC1_MOUSE
NC score	0.066270 (rank : 592)	θ value	θ > 10 (rank : 617)
Query Neighborhood Hits	531	Target Neighborhood Hits	230	Shared Neighborhood Hits	65
SwissProt Accessions	Q68ED7, Q6ZQ85	Gene names	Crtc1, Kiaa0616, Mect1
Domain Architecture	No domain graphic available
Description	CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1 homolog).

T22D2_HUMAN
NC score	0.066227 (rank : 593)	θ value	θ > 10 (rank : 1001)
Query Neighborhood Hits	531	Target Neighborhood Hits	250	Shared Neighborhood Hits	64
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

SF3B1_HUMAN
NC score	0.066200 (rank : 594)	θ value	θ > 10 (rank : 931)
Query Neighborhood Hits	531	Target Neighborhood Hits	341	Shared Neighborhood Hits	75
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

ITSN2_MOUSE
NC score	0.066154 (rank : 595)	θ value	θ > 10 (rank : 763)
Query Neighborhood Hits	531	Target Neighborhood Hits	1371	Shared Neighborhood Hits	99
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

CNOT3_HUMAN
NC score	0.066060 (rank : 596)	θ value	θ > 10 (rank : 609)
Query Neighborhood Hits	531	Target Neighborhood Hits	425	Shared Neighborhood Hits	64
SwissProt Accessions	O75175, Q9NZN7, Q9UF76	Gene names	CNOT3, KIAA0691, NOT3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

VASP_HUMAN
NC score	0.065954 (rank : 597)	θ value	θ > 10 (rank : 1037)
Query Neighborhood Hits	531	Target Neighborhood Hits	201	Shared Neighborhood Hits	52
SwissProt Accessions	P50552, Q6PIZ1, Q93035	Gene names	VASP
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

PACN1_HUMAN
NC score	0.065669 (rank : 598)	θ value	θ > 10 (rank : 857)
Query Neighborhood Hits	531	Target Neighborhood Hits	320	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

NFAC1_HUMAN
NC score	0.065300 (rank : 599)	θ value	5.27518 (rank : 444)
Query Neighborhood Hits	531	Target Neighborhood Hits	312	Shared Neighborhood Hits	93
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

ZCH14_HUMAN
NC score	0.065147 (rank : 600)	θ value	1.06291 (rank : 293)
Query Neighborhood Hits	531	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	Q8WYQ9, O60324, Q9UFP0	Gene names	ZCCHC14, KIAA0579
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 14 (BDG-29).

MUC1_MOUSE
NC score	0.065030 (rank : 601)	θ value	θ > 10 (rank : 821)
Query Neighborhood Hits	531	Target Neighborhood Hits	388	Shared Neighborhood Hits	57
SwissProt Accessions	Q02496	Gene names	Muc1, Muc-1
Domain Architecture
Description	Mucin-1 precursor (Polymorphic epithelial mucin) (PEMT) (Episialin).

TCF20_MOUSE
NC score	0.065027 (rank : 602)	θ value	θ > 10 (rank : 1009)
Query Neighborhood Hits	531	Target Neighborhood Hits	396	Shared Neighborhood Hits	67
SwissProt Accessions	Q9EPQ8, Q60792	Gene names	Tcf20, Spbp
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP).

ARHG6_MOUSE
NC score	0.064946 (rank : 603)	θ value	θ > 10 (rank : 566)
Query Neighborhood Hits	531	Target Neighborhood Hits	394	Shared Neighborhood Hits	52
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

JIP1_HUMAN
NC score	0.064787 (rank : 604)	θ value	θ > 10 (rank : 768)
Query Neighborhood Hits	531	Target Neighborhood Hits	271	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

SNIP_HUMAN
NC score	0.064251 (rank : 605)	θ value	2.36792 (rank : 354)
Query Neighborhood Hits	531	Target Neighborhood Hits	313	Shared Neighborhood Hits	49
SwissProt Accessions	Q9C0H9, Q8N4W8	Gene names	P140, KIAA1684
Domain Architecture	No domain graphic available
Description	p130Cas-associated protein (p140Cap) (SNAP-25-interacting protein) (SNIP).

PRGC2_HUMAN
NC score	0.064217 (rank : 606)	θ value	3.0926 (rank : 377)
Query Neighborhood Hits	531	Target Neighborhood Hits	272	Shared Neighborhood Hits	70
SwissProt Accessions	Q86YN6, Q86YN3, Q86YN4, Q86YN5, Q8N1N9, Q8TDE4, Q8TDE5	Gene names	PPARGC1B, PERC, PGC1, PGC1B, PPARGC1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta) (PGC-1-related estrogen receptor alpha coactivator) (PPARGC-1-beta) (PGC-1-beta).

PACN1_MOUSE
NC score	0.064111 (rank : 607)	θ value	θ > 10 (rank : 858)
Query Neighborhood Hits	531	Target Neighborhood Hits	283	Shared Neighborhood Hits	48
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

MUC5B_HUMAN
NC score	0.064053 (rank : 608)	θ value	θ > 10 (rank : 822)
Query Neighborhood Hits	531	Target Neighborhood Hits	1020	Shared Neighborhood Hits	108
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

ES8L3_MOUSE
NC score	0.063950 (rank : 609)	θ value	θ > 10 (rank : 695)
Query Neighborhood Hits	531	Target Neighborhood Hits	168	Shared Neighborhood Hits	42
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

RIN3_MOUSE
NC score	0.063912 (rank : 610)	θ value	3.0926 (rank : 379)
Query Neighborhood Hits	531	Target Neighborhood Hits	239	Shared Neighborhood Hits	73
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

NUP53_HUMAN
NC score	0.063823 (rank : 611)	θ value	θ > 10 (rank : 851)
Query Neighborhood Hits	531	Target Neighborhood Hits	156	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NFH5, Q4ZFZ9, Q53S95, Q8TDJ1	Gene names	NUP35, MP44, NUP53
Domain Architecture	No domain graphic available
Description	Nucleoporin NUP53 (Nuclear pore complex protein Nup53) (Nucleoporin Nup35) (35 kDa nucleoporin) (Mitotic phosphoprotein 44) (MP-44).

VGF_HUMAN
NC score	0.063461 (rank : 612)	θ value	θ > 10 (rank : 1050)
Query Neighborhood Hits	531	Target Neighborhood Hits	167	Shared Neighborhood Hits	24
SwissProt Accessions	O15240	Gene names	VGF
Domain Architecture	No domain graphic available
Description	Neurosecretory protein VGF precursor.

MYST3_HUMAN
NC score	0.062964 (rank : 613)	θ value	1.81305 (rank : 327)
Query Neighborhood Hits	531	Target Neighborhood Hits	772	Shared Neighborhood Hits	106
SwissProt Accessions	Q92794	Gene names	MYST3, MOZ, RUNXBP2, ZNF220
Domain Architecture
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Runt-related transcription factor-binding protein 2) (Monocytic leukemia zinc finger protein) (Zinc finger protein 220).

FOXN1_HUMAN
NC score	0.062696 (rank : 614)	θ value	3.0926 (rank : 369)
Query Neighborhood Hits	531	Target Neighborhood Hits	377	Shared Neighborhood Hits	107
SwissProt Accessions	O15353, O15352	Gene names	FOXN1, WHN
Domain Architecture
Description	Forkhead box protein N1 (Transcription factor winged-helix nude).

LEUK_HUMAN
NC score	0.062627 (rank : 615)	θ value	θ > 10 (rank : 788)
Query Neighborhood Hits	531	Target Neighborhood Hits	213	Shared Neighborhood Hits	50
SwissProt Accessions	P16150	Gene names	SPN, CD43
Domain Architecture	No domain graphic available
Description	Leukosialin precursor (Leukocyte sialoglycoprotein) (Sialophorin) (Galactoglycoprotein) (GALGP) (CD43 antigen).

LTK_HUMAN
NC score	0.062540 (rank : 616)	θ value	θ > 10 (rank : 793)
Query Neighborhood Hits	531	Target Neighborhood Hits	774	Shared Neighborhood Hits	44
SwissProt Accessions	P29376	Gene names	LTK, TYK1
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1) (Protein tyrosine kinase 1).

ANM2_HUMAN
NC score	0.062405 (rank : 617)	θ value	θ > 10 (rank : 555)
Query Neighborhood Hits	531	Target Neighborhood Hits	175	Shared Neighborhood Hits	44
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SOCS4_MOUSE
NC score	0.062370 (rank : 618)	θ value	θ > 10 (rank : 965)
Query Neighborhood Hits	531	Target Neighborhood Hits	69	Shared Neighborhood Hits	29
SwissProt Accessions	Q91ZA6	Gene names	Socs4, Socs7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

PHAR2_HUMAN
NC score	0.062344 (rank : 619)	θ value	0.62314 (rank : 255)
Query Neighborhood Hits	531	Target Neighborhood Hits	208	Shared Neighborhood Hits	32
SwissProt Accessions	O75167, Q68DM2	Gene names	PHACTR2, C6orf56, KIAA0680
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 2.

LTK_MOUSE
NC score	0.062253 (rank : 620)	θ value	θ > 10 (rank : 794)
Query Neighborhood Hits	531	Target Neighborhood Hits	770	Shared Neighborhood Hits	46
SwissProt Accessions	P08923	Gene names	Ltk
Domain Architecture
Description	Leukocyte tyrosine kinase receptor precursor (EC 2.7.10.1).

EPHB6_HUMAN
NC score	0.062104 (rank : 621)	θ value	θ > 10 (rank : 681)
Query Neighborhood Hits	531	Target Neighborhood Hits	912	Shared Neighborhood Hits	65
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

SASH1_HUMAN
NC score	0.062100 (rank : 622)	θ value	0.813845 (rank : 270)
Query Neighborhood Hits	531	Target Neighborhood Hits	292	Shared Neighborhood Hits	65
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SNPC4_MOUSE
NC score	0.062087 (rank : 623)	θ value	θ > 10 (rank : 959)
Query Neighborhood Hits	531	Target Neighborhood Hits	237	Shared Neighborhood Hits	73
SwissProt Accessions	Q8BP86, Q6PGG7, Q80UG9, Q810L1	Gene names	Snapc4
Domain Architecture	No domain graphic available
Description	snRNA-activating protein complex subunit 4 (SNAPc subunit 4) (snRNA- activating protein complex 190 kDa subunit) (SNAPc 190 kDa subunit).

CNOT3_MOUSE
NC score	0.061957 (rank : 624)	θ value	θ > 10 (rank : 610)
Query Neighborhood Hits	531	Target Neighborhood Hits	504	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K0V4	Gene names	Cnot3, Not3
Domain Architecture
Description	CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3).

ALK_MOUSE
NC score	0.061921 (rank : 625)	θ value	θ > 10 (rank : 552)
Query Neighborhood Hits	531	Target Neighborhood Hits	811	Shared Neighborhood Hits	49
SwissProt Accessions	P97793	Gene names	Alk
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

NPAS4_MOUSE
NC score	0.061694 (rank : 626)	θ value	θ > 10 (rank : 838)
Query Neighborhood Hits	531	Target Neighborhood Hits	245	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BGD7, Q3V3U3	Gene names	Npas4, Nxf
Domain Architecture	No domain graphic available
Description	Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (HLH-PAS transcription factor NXF) (Limbic-enhanced PAS protein) (LE-PAS).

SOCS4_HUMAN
NC score	0.061687 (rank : 627)	θ value	θ > 10 (rank : 964)
Query Neighborhood Hits	531	Target Neighborhood Hits	69	Shared Neighborhood Hits	30
SwissProt Accessions	Q8WXH5	Gene names	SOCS4, SOCS7
Domain Architecture
Description	Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7).

TNK1_HUMAN
NC score	0.061581 (rank : 628)	θ value	θ > 10 (rank : 1022)
Query Neighborhood Hits	531	Target Neighborhood Hits	815	Shared Neighborhood Hits	55
SwissProt Accessions	Q13470, O95364, Q8IYI4	Gene names	TNK1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1).

RYK_HUMAN
NC score	0.061567 (rank : 629)	θ value	θ > 10 (rank : 919)
Query Neighborhood Hits	531	Target Neighborhood Hits	701	Shared Neighborhood Hits	44
SwissProt Accessions	P34925, Q04696	Gene names	RYK, JTK5A
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1).

GTSE1_MOUSE
NC score	0.061514 (rank : 630)	θ value	θ > 10 (rank : 735)
Query Neighborhood Hits	531	Target Neighborhood Hits	245	Shared Neighborhood Hits	75
SwissProt Accessions	Q8R080, O89015, Q9CSG9	Gene names	Gtse1, B99
Domain Architecture	No domain graphic available
Description	G2 and S phase expressed protein 1 (Gtse-1) (B99 protein).

ALK_HUMAN
NC score	0.061470 (rank : 631)	θ value	θ > 10 (rank : 551)
Query Neighborhood Hits	531	Target Neighborhood Hits	795	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UM73, Q9Y4K6	Gene names	ALK
Domain Architecture
Description	ALK tyrosine kinase receptor precursor (EC 2.7.10.1) (Anaplastic lymphoma kinase) (CD246 antigen).

ROS_HUMAN
NC score	0.061176 (rank : 632)	θ value	θ > 10 (rank : 915)
Query Neighborhood Hits	531	Target Neighborhood Hits	907	Shared Neighborhood Hits	47
SwissProt Accessions	P08922, Q15368	Gene names	ROS1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c- ros-1).

RYK_MOUSE
NC score	0.061167 (rank : 633)	θ value	θ > 10 (rank : 920)
Query Neighborhood Hits	531	Target Neighborhood Hits	715	Shared Neighborhood Hits	44
SwissProt Accessions	Q01887, Q61890	Gene names	Ryk, Mrk
Domain Architecture
Description	Tyrosine-protein kinase RYK precursor (EC 2.7.10.1) (Kinase VIK) (NYK- R) (Met-related kinase).

SMOO_HUMAN
NC score	0.061082 (rank : 634)	θ value	θ > 10 (rank : 957)
Query Neighborhood Hits	531	Target Neighborhood Hits	391	Shared Neighborhood Hits	85
SwissProt Accessions	P53814, O00569, O95769, O95937, Q9P1S8, Q9UIT1, Q9UIT2	Gene names	SMTN, SMSMO
Domain Architecture
Description	Smoothelin.

STYK1_MOUSE
NC score	0.060971 (rank : 635)	θ value	θ > 10 (rank : 997)
Query Neighborhood Hits	531	Target Neighborhood Hits	779	Shared Neighborhood Hits	44
SwissProt Accessions	Q6J9G1, Q8BZH6, Q8BZT1	Gene names	Styk1, Nok
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (mNOK).

TCF20_HUMAN
NC score	0.060826 (rank : 636)	θ value	θ > 10 (rank : 1008)
Query Neighborhood Hits	531	Target Neighborhood Hits	323	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UGU0, O14528, Q13078, Q4V353, Q9H4M0	Gene names	TCF20, KIAA0292, SPBP
Domain Architecture	No domain graphic available
Description	Transcription factor 20 (Stromelysin 1 PDGF-responsive element-binding protein) (SPRE-binding protein) (Nuclear factor SPBP) (AR1).

TITIN_HUMAN
NC score	0.060751 (rank : 637)	θ value	0.00390308 (rank : 57)
Query Neighborhood Hits	531	Target Neighborhood Hits	2923	Shared Neighborhood Hits	215
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

DCC_MOUSE
NC score	0.060725 (rank : 638)	θ value	θ > 10 (rank : 633)
Query Neighborhood Hits	531	Target Neighborhood Hits	896	Shared Neighborhood Hits	162
SwissProt Accessions	P70211	Gene names	Dcc
Domain Architecture
Description	Netrin receptor DCC precursor (Tumor suppressor protein DCC).

SHAN2_HUMAN
NC score	0.060689 (rank : 639)	θ value	8.99809 (rank : 524)
Query Neighborhood Hits	531	Target Neighborhood Hits	346	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

AHI1_MOUSE
NC score	0.060619 (rank : 640)	θ value	θ > 10 (rank : 548)
Query Neighborhood Hits	531	Target Neighborhood Hits	496	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

M3K9_HUMAN
NC score	0.060595 (rank : 641)	θ value	θ > 10 (rank : 796)
Query Neighborhood Hits	531	Target Neighborhood Hits	1123	Shared Neighborhood Hits	103
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

STYK1_HUMAN
NC score	0.060434 (rank : 642)	θ value	θ > 10 (rank : 996)
Query Neighborhood Hits	531	Target Neighborhood Hits	786	Shared Neighborhood Hits	43
SwissProt Accessions	Q6J9G0, Q9BXY2, Q9NSH1	Gene names	STYK1, NOK
Domain Architecture	No domain graphic available
Description	Tyrosine protein-kinase STYK1 (EC 2.7.10.2) (Serine/threonine/tyrosine kinase 1) (Novel oncogene with kinase-domain) (Protein PK-unique).

ES8L1_HUMAN
NC score	0.060141 (rank : 643)	θ value	θ > 10 (rank : 690)
Query Neighborhood Hits	531	Target Neighborhood Hits	162	Shared Neighborhood Hits	39
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

EPHAA_HUMAN
NC score	0.060087 (rank : 644)	θ value	θ > 10 (rank : 673)
Query Neighborhood Hits	531	Target Neighborhood Hits	960	Shared Neighborhood Hits	54
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

MYST3_MOUSE
NC score	0.060067 (rank : 645)	θ value	θ > 10 (rank : 827)
Query Neighborhood Hits	531	Target Neighborhood Hits	688	Shared Neighborhood Hits	105
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

GAB2_MOUSE
NC score	0.060067 (rank : 646)	θ value	θ > 10 (rank : 720)
Query Neighborhood Hits	531	Target Neighborhood Hits	220	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

DBNL_MOUSE
NC score	0.060029 (rank : 647)	θ value	θ > 10 (rank : 632)
Query Neighborhood Hits	531	Target Neighborhood Hits	306	Shared Neighborhood Hits	57
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

PRPE_HUMAN
NC score	0.059994 (rank : 648)	θ value	θ > 10 (rank : 890)
Query Neighborhood Hits	531	Target Neighborhood Hits	44	Shared Neighborhood Hits	13
SwissProt Accessions	P02811	Gene names
Domain Architecture	No domain graphic available
Description	Basic proline-rich peptide P-E (IB-9).

EPHB6_MOUSE
NC score	0.059821 (rank : 649)	θ value	θ > 10 (rank : 682)
Query Neighborhood Hits	531	Target Neighborhood Hits	906	Shared Neighborhood Hits	57
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

ANR11_HUMAN
NC score	0.059744 (rank : 650)	θ value	θ > 10 (rank : 558)
Query Neighborhood Hits	531	Target Neighborhood Hits	1289	Shared Neighborhood Hits	147
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

TNK1_MOUSE
NC score	0.059699 (rank : 651)	θ value	θ > 10 (rank : 1023)
Query Neighborhood Hits	531	Target Neighborhood Hits	806	Shared Neighborhood Hits	54
SwissProt Accessions	Q99ML2, Q8CCC4, Q8K0X9, Q91V11	Gene names	Tnk1, Kos1
Domain Architecture	No domain graphic available
Description	Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (Kinase of embryonic stem cells).

EPHA1_MOUSE
NC score	0.059693 (rank : 652)	θ value	θ > 10 (rank : 658)
Query Neighborhood Hits	531	Target Neighborhood Hits	958	Shared Neighborhood Hits	56
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

DDR1_MOUSE
NC score	0.059631 (rank : 653)	θ value	θ > 10 (rank : 636)
Query Neighborhood Hits	531	Target Neighborhood Hits	818	Shared Neighborhood Hits	47
SwissProt Accessions	Q03146	Gene names	Ddr1, Cak, Eddr1, Mpk6
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (Protein-tyrosine kinase MPK-6) (CD167a antigen).

JPH2_MOUSE
NC score	0.059622 (rank : 654)	θ value	0.279714 (rank : 196)
Query Neighborhood Hits	531	Target Neighborhood Hits	279	Shared Neighborhood Hits	59
SwissProt Accessions	Q9ET78, Q9ET79	Gene names	Jph2, Jp2
Domain Architecture	No domain graphic available
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

ERBB2_MOUSE
NC score	0.059583 (rank : 655)	θ value	θ > 10 (rank : 686)
Query Neighborhood Hits	531	Target Neighborhood Hits	918	Shared Neighborhood Hits	58
SwissProt Accessions	P70424, Q61525, Q6ZPE0	Gene names	Erbb2, Kiaa3023, Neu
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-2 precursor (EC 2.7.10.1) (p185erbB2) (C-erbB-2) (NEU proto-oncogene).

EPHA1_HUMAN
NC score	0.059480 (rank : 656)	θ value	θ > 10 (rank : 657)
Query Neighborhood Hits	531	Target Neighborhood Hits	997	Shared Neighborhood Hits	53
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

DDR1_HUMAN
NC score	0.059435 (rank : 657)	θ value	θ > 10 (rank : 635)
Query Neighborhood Hits	531	Target Neighborhood Hits	819	Shared Neighborhood Hits	47
SwissProt Accessions	Q08345, Q14196, Q16562, Q5ST12, Q9UD37	Gene names	DDR1, CAK, EDDR1, RTK6, TRKE
Domain Architecture
Description	Epithelial discoidin domain-containing receptor 1 precursor (EC 2.7.10.1) (Epithelial discoidin domain receptor 1) (Tyrosine kinase DDR) (Discoidin receptor tyrosine kinase) (Tyrosine-protein kinase CAK) (Cell adhesion kinase) (TRK E) (Protein-tyrosine kinase RTK 6) (HGK2) (CD167a antigen).

SF01_MOUSE
NC score	0.059423 (rank : 658)	θ value	θ > 10 (rank : 929)
Query Neighborhood Hits	531	Target Neighborhood Hits	240	Shared Neighborhood Hits	63
SwissProt Accessions	Q64213, O08817, P70167, Q61454, Q921Z4	Gene names	Sf1, Zfm1, Zfp162
Domain Architecture
Description	Splicing factor 1 (Zinc finger protein 162) (Transcription factor ZFM1) (mZFM) (Zinc finger gene in MEN1 locus) (Mammalian branch point- binding protein mBBP) (BBP) (CW17).

CHIN_MOUSE
NC score	0.059377 (rank : 659)	θ value	θ > 10 (rank : 600)
Query Neighborhood Hits	531	Target Neighborhood Hits	229	Shared Neighborhood Hits	60
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

LEO1_MOUSE
NC score	0.059349 (rank : 660)	θ value	0.21417 (rank : 178)
Query Neighborhood Hits	531	Target Neighborhood Hits	946	Shared Neighborhood Hits	73
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

FHOD1_MOUSE
NC score	0.059314 (rank : 661)	θ value	θ > 10 (rank : 712)
Query Neighborhood Hits	531	Target Neighborhood Hits	217	Shared Neighborhood Hits	57
SwissProt Accessions	Q6P9Q4, Q8BMK2	Gene names	Fhod1, Fhos1
Domain Architecture	No domain graphic available
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

FAK2_HUMAN
NC score	0.059281 (rank : 662)	θ value	θ > 10 (rank : 700)
Query Neighborhood Hits	531	Target Neighborhood Hits	847	Shared Neighborhood Hits	50
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

EPHA5_MOUSE
NC score	0.059249 (rank : 663)	θ value	θ > 10 (rank : 666)
Query Neighborhood Hits	531	Target Neighborhood Hits	950	Shared Neighborhood Hits	53
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

ZO1_HUMAN
NC score	0.059231 (rank : 664)	θ value	0.365318 (rank : 225)
Query Neighborhood Hits	531	Target Neighborhood Hits	474	Shared Neighborhood Hits	100
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

NCOR1_HUMAN
NC score	0.059175 (rank : 665)	θ value	θ > 10 (rank : 832)
Query Neighborhood Hits	531	Target Neighborhood Hits	577	Shared Neighborhood Hits	87
SwissProt Accessions	O75376, Q9UPV5, Q9UQ18	Gene names	NCOR1, KIAA1047
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR).

RSMB_HUMAN
NC score	0.059154 (rank : 666)	θ value	0.279714 (rank : 203)
Query Neighborhood Hits	531	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	P14678, Q15490, Q9UIS5	Gene names	SNRPB, COD, SNRPB1
Domain Architecture
Description	Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/Sm-B') (SmB/SmB').

FAK2_MOUSE
NC score	0.059034 (rank : 667)	θ value	θ > 10 (rank : 701)
Query Neighborhood Hits	531	Target Neighborhood Hits	851	Shared Neighborhood Hits	50
SwissProt Accessions	Q9QVP9	Gene names	Ptk2b, Fak2, Pyk2, Raftk
Domain Architecture	No domain graphic available
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

OBSCN_HUMAN
NC score	0.059010 (rank : 668)	θ value	0.163984 (rank : 165)
Query Neighborhood Hits	531	Target Neighborhood Hits	1931	Shared Neighborhood Hits	194
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

EPHA6_HUMAN
NC score	0.059004 (rank : 669)	θ value	θ > 10 (rank : 667)
Query Neighborhood Hits	531	Target Neighborhood Hits	959	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

MAML3_HUMAN
NC score	0.058919 (rank : 670)	θ value	θ > 10 (rank : 800)
Query Neighborhood Hits	531	Target Neighborhood Hits	323	Shared Neighborhood Hits	55
SwissProt Accessions	Q96JK9	Gene names	MAML3, KIAA1816
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 3 (Mam-3).

PO6F2_MOUSE
NC score	0.058900 (rank : 671)	θ value	0.163984 (rank : 167)
Query Neighborhood Hits	531	Target Neighborhood Hits	639	Shared Neighborhood Hits	83
SwissProt Accessions	Q8BJI4	Gene names	Pou6f2
Domain Architecture	No domain graphic available
Description	POU domain, class 6, transcription factor 2.

LEO1_HUMAN
NC score	0.058796 (rank : 672)	θ value	0.62314 (rank : 246)
Query Neighborhood Hits	531	Target Neighborhood Hits	958	Shared Neighborhood Hits	71
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

SPRR3_MOUSE
NC score	0.058705 (rank : 673)	θ value	θ > 10 (rank : 978)
Query Neighborhood Hits	531	Target Neighborhood Hits	106	Shared Neighborhood Hits	27
SwissProt Accessions	O09116	Gene names	Sprr3
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta).

LASP1_HUMAN
NC score	0.058690 (rank : 674)	θ value	θ > 10 (rank : 784)
Query Neighborhood Hits	531	Target Neighborhood Hits	293	Shared Neighborhood Hits	48
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

EPHA6_MOUSE
NC score	0.058654 (rank : 675)	θ value	θ > 10 (rank : 668)
Query Neighborhood Hits	531	Target Neighborhood Hits	946	Shared Neighborhood Hits	50
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

CNOT4_MOUSE
NC score	0.058627 (rank : 676)	θ value	θ > 10 (rank : 611)
Query Neighborhood Hits	531	Target Neighborhood Hits	277	Shared Neighborhood Hits	68
SwissProt Accessions	Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0	Gene names	Cnot4, Not4
Domain Architecture
Description	CCR4-NOT transcription complex subunit 4 (EC 6.3.2.-) (E3 ubiquitin protein ligase CNOT4) (CCR4-associated factor 4) (Potential transcriptional repressor NOT4Hp).

EPHA2_MOUSE
NC score	0.058613 (rank : 677)	θ value	θ > 10 (rank : 660)
Query Neighborhood Hits	531	Target Neighborhood Hits	1020	Shared Neighborhood Hits	54
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

SSBP3_HUMAN
NC score	0.058582 (rank : 678)	θ value	6.88961 (rank : 490)
Query Neighborhood Hits	531	Target Neighborhood Hits	132	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BWW4, Q9BTM0, Q9BWW3	Gene names	SSBP3, SSDP, SSDP1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein).

SSBP3_MOUSE
NC score	0.058582 (rank : 679)	θ value	6.88961 (rank : 491)
Query Neighborhood Hits	531	Target Neighborhood Hits	132	Shared Neighborhood Hits	49
SwissProt Accessions	Q9D032, Q99LC6, Q9EQP3	Gene names	Ssbp3, Last, Ssdp1
Domain Architecture
Description	Single-stranded DNA-binding protein 3 (Sequence-specific single- stranded-DNA-binding protein) (Lck-associated signal transducer).

MERTK_HUMAN
NC score	0.058574 (rank : 680)	θ value	θ > 10 (rank : 811)
Query Neighborhood Hits	531	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	Q12866, Q9HBB4	Gene names	MERTK, MER
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

M3KL4_HUMAN
NC score	0.058573 (rank : 681)	θ value	θ > 10 (rank : 797)
Query Neighborhood Hits	531	Target Neighborhood Hits	1087	Shared Neighborhood Hits	75
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SPEG_HUMAN
NC score	0.058529 (rank : 682)	θ value	θ > 10 (rank : 972)
Query Neighborhood Hits	531	Target Neighborhood Hits	1762	Shared Neighborhood Hits	192
SwissProt Accessions	Q15772, Q27J74, Q695L1, Q6FGA6, Q6ZQW1, Q6ZTL8, Q9P2P9	Gene names	SPEG, APEG1, KIAA1297
Domain Architecture
Description	Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1).

SMRC2_HUMAN
NC score	0.058512 (rank : 683)	θ value	θ > 10 (rank : 958)
Query Neighborhood Hits	531	Target Neighborhood Hits	499	Shared Neighborhood Hits	86
SwissProt Accessions	Q8TAQ2, Q92923, Q96E12, Q96GY4	Gene names	SMARCC2, BAF170
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 (SWI/SNF complex 170 kDa subunit) (BRG1-associated factor 170).

EPHA2_HUMAN
NC score	0.058412 (rank : 684)	θ value	θ > 10 (rank : 659)
Query Neighborhood Hits	531	Target Neighborhood Hits	1021	Shared Neighborhood Hits	53
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

LASP1_MOUSE
NC score	0.058397 (rank : 685)	θ value	θ > 10 (rank : 785)
Query Neighborhood Hits	531	Target Neighborhood Hits	297	Shared Neighborhood Hits	48
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

EPHB3_HUMAN
NC score	0.058393 (rank : 686)	θ value	θ > 10 (rank : 677)
Query Neighborhood Hits	531	Target Neighborhood Hits	996	Shared Neighborhood Hits	57
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

DBNL_HUMAN
NC score	0.058332 (rank : 687)	θ value	θ > 10 (rank : 631)
Query Neighborhood Hits	531	Target Neighborhood Hits	244	Shared Neighborhood Hits	51
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

INSRR_HUMAN
NC score	0.058326 (rank : 688)	θ value	θ > 10 (rank : 755)
Query Neighborhood Hits	531	Target Neighborhood Hits	950	Shared Neighborhood Hits	53
SwissProt Accessions	P14616, O60724	Gene names	INSRR, IRR
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

HSF1_MOUSE
NC score	0.058174 (rank : 689)	θ value	θ > 10 (rank : 740)
Query Neighborhood Hits	531	Target Neighborhood Hits	267	Shared Neighborhood Hits	76
SwissProt Accessions	P38532, O70462	Gene names	Hsf1
Domain Architecture
Description	Heat shock factor protein 1 (HSF 1) (Heat shock transcription factor 1) (HSTF 1).

IGF1R_MOUSE
NC score	0.058151 (rank : 690)	θ value	θ > 10 (rank : 748)
Query Neighborhood Hits	531	Target Neighborhood Hits	973	Shared Neighborhood Hits	49
SwissProt Accessions	Q60751, O70438, Q62123	Gene names	Igf1r
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

FLT3_MOUSE
NC score	0.058117 (rank : 691)	θ value	θ > 10 (rank : 714)
Query Neighborhood Hits	531	Target Neighborhood Hits	847	Shared Neighborhood Hits	45
SwissProt Accessions	Q00342	Gene names	Flt3, Flk-2, Flt-3
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor flk-2) (Fetal liver kinase 2) (Tyrosine-protein kinase FLT3) (CD135 antigen).

MERTK_MOUSE
NC score	0.058075 (rank : 692)	θ value	θ > 10 (rank : 812)
Query Neighborhood Hits	531	Target Neighborhood Hits	974	Shared Neighborhood Hits	55
SwissProt Accessions	Q60805, Q62194	Gene names	Mertk, Mer
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase MER precursor (EC 2.7.10.1) (C- mer) (Receptor tyrosine kinase MerTK).

M3K10_HUMAN
NC score	0.058069 (rank : 693)	θ value	θ > 10 (rank : 795)
Query Neighborhood Hits	531	Target Neighborhood Hits	1071	Shared Neighborhood Hits	82
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

CI079_HUMAN
NC score	0.058056 (rank : 694)	θ value	θ > 10 (rank : 601)
Query Neighborhood Hits	531	Target Neighborhood Hits	288	Shared Neighborhood Hits	64
SwissProt Accessions	Q6ZUB1, Q5SQC9, Q8NA41, Q8ND27	Gene names	C9orf79
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf79.

ERBB4_HUMAN
NC score	0.058055 (rank : 695)	θ value	θ > 10 (rank : 689)
Query Neighborhood Hits	531	Target Neighborhood Hits	910	Shared Neighborhood Hits	49
SwissProt Accessions	Q15303	Gene names	ERBB4, HER4
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-4 precursor (EC 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4).

SOX30_HUMAN
NC score	0.058026 (rank : 696)	θ value	θ > 10 (rank : 971)
Query Neighborhood Hits	531	Target Neighborhood Hits	305	Shared Neighborhood Hits	79
SwissProt Accessions	O94993, O94995, Q8IYX6	Gene names	SOX30
Domain Architecture
Description	Transcription factor SOX-30.

IGF1R_HUMAN
NC score	0.058002 (rank : 697)	θ value	θ > 10 (rank : 747)
Query Neighborhood Hits	531	Target Neighborhood Hits	977	Shared Neighborhood Hits	51
SwissProt Accessions	P08069	Gene names	IGF1R
Domain Architecture
Description	Insulin-like growth factor 1 receptor precursor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD221 antigen) [Contains: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain].

EPHB4_HUMAN
NC score	0.057998 (rank : 698)	θ value	θ > 10 (rank : 679)
Query Neighborhood Hits	531	Target Neighborhood Hits	1056	Shared Neighborhood Hits	55
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB3_MOUSE
NC score	0.057997 (rank : 699)	θ value	θ > 10 (rank : 678)
Query Neighborhood Hits	531	Target Neighborhood Hits	996	Shared Neighborhood Hits	55
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

INSRR_MOUSE
NC score	0.057901 (rank : 700)	θ value	θ > 10 (rank : 756)
Query Neighborhood Hits	531	Target Neighborhood Hits	961	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WTL4	Gene names	Insrr, Irr
Domain Architecture
Description	Insulin receptor-related protein precursor (EC 2.7.10.1) (IRR) (IR- related receptor) [Contains: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain].

ROR2_MOUSE
NC score	0.057844 (rank : 701)	θ value	θ > 10 (rank : 914)
Query Neighborhood Hits	531	Target Neighborhood Hits	1000	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Z138	Gene names	Ror2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) (mROR2).

ILK_MOUSE
NC score	0.057807 (rank : 702)	θ value	θ > 10 (rank : 753)
Query Neighborhood Hits	531	Target Neighborhood Hits	858	Shared Neighborhood Hits	52
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

NELFA_HUMAN
NC score	0.057757 (rank : 703)	θ value	θ > 10 (rank : 834)
Query Neighborhood Hits	531	Target Neighborhood Hits	161	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H3P2, O95392	Gene names	WHSC2, NELFA
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein).

RIMB1_HUMAN
NC score	0.057740 (rank : 704)	θ value	θ > 10 (rank : 906)
Query Neighborhood Hits	531	Target Neighborhood Hits	1479	Shared Neighborhood Hits	166
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

EPHB4_MOUSE
NC score	0.057725 (rank : 705)	θ value	θ > 10 (rank : 680)
Query Neighborhood Hits	531	Target Neighborhood Hits	1013	Shared Neighborhood Hits	56
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

RECQ5_HUMAN
NC score	0.057718 (rank : 706)	θ value	θ > 10 (rank : 903)
Query Neighborhood Hits	531	Target Neighborhood Hits	390	Shared Neighborhood Hits	100
SwissProt Accessions	O94762, Q9P1W7, Q9UNC8	Gene names	RECQL5, RECQ5
Domain Architecture
Description	ATP-dependent DNA helicase Q5 (EC 3.6.1.-) (RecQ protein-like 5) (RecQ5).

FAK1_HUMAN
NC score	0.057708 (rank : 707)	θ value	θ > 10 (rank : 698)
Query Neighborhood Hits	531	Target Neighborhood Hits	850	Shared Neighborhood Hits	48
SwissProt Accessions	Q05397, Q14291, Q9UD85	Gene names	PTK2, FAK, FAK1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK) (Protein- tyrosine kinase 2).

PKHA6_MOUSE
NC score	0.057705 (rank : 708)	θ value	θ > 10 (rank : 879)
Query Neighborhood Hits	531	Target Neighborhood Hits	591	Shared Neighborhood Hits	88
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

NTRK1_HUMAN
NC score	0.057670 (rank : 709)	θ value	θ > 10 (rank : 844)
Query Neighborhood Hits	531	Target Neighborhood Hits	1023	Shared Neighborhood Hits	51
SwissProt Accessions	P04629, P08119, Q15655, Q15656, Q5D056, Q5VZS2, Q9UIU7	Gene names	NTRK1, TRK
Domain Architecture
Description	High affinity nerve growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1 transforming tyrosine kinase protein) (p140-TrkA) (Trk-A).

PO6F2_HUMAN
NC score	0.057625 (rank : 710)	θ value	1.81305 (rank : 329)
Query Neighborhood Hits	531	Target Neighborhood Hits	618	Shared Neighborhood Hits	91
SwissProt Accessions	P78424, P78425, Q75ME8, Q86UM6, Q9UDS7	Gene names	POU6F2, RPF1
Domain Architecture
Description	POU domain, class 6, transcription factor 2 (Retina-derived POU-domain factor 1) (RPF-1).

EPHA5_HUMAN
NC score	0.057593 (rank : 711)	θ value	θ > 10 (rank : 665)
Query Neighborhood Hits	531	Target Neighborhood Hits	1009	Shared Neighborhood Hits	55
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

PKHA6_HUMAN
NC score	0.057511 (rank : 712)	θ value	θ > 10 (rank : 878)
Query Neighborhood Hits	531	Target Neighborhood Hits	556	Shared Neighborhood Hits	86
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

FLT3_HUMAN
NC score	0.057472 (rank : 713)	θ value	θ > 10 (rank : 713)
Query Neighborhood Hits	531	Target Neighborhood Hits	843	Shared Neighborhood Hits	45
SwissProt Accessions	P36888, Q13414	Gene names	FLT3, STK1
Domain Architecture
Description	FL cytokine receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor FLT3) (Stem cell tyrosine kinase 1) (STK-1) (CD135 antigen).

PLCD1_HUMAN
NC score	0.057469 (rank : 714)	θ value	θ > 10 (rank : 880)
Query Neighborhood Hits	531	Target Neighborhood Hits	93	Shared Neighborhood Hits	8
SwissProt Accessions	P51178	Gene names	PLCD1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

NTRK3_HUMAN
NC score	0.057465 (rank : 715)	θ value	θ > 10 (rank : 847)
Query Neighborhood Hits	531	Target Neighborhood Hits	1115	Shared Neighborhood Hits	52
SwissProt Accessions	Q16288, Q12827, Q16289	Gene names	NTRK3, TRKC
Domain Architecture
Description	NT-3 growth factor receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) (GP145-TrkC) (Trk-C).

FAK1_MOUSE
NC score	0.057463 (rank : 716)	θ value	θ > 10 (rank : 699)
Query Neighborhood Hits	531	Target Neighborhood Hits	850	Shared Neighborhood Hits	47
SwissProt Accessions	P34152, O08578	Gene names	Ptk2, Fadk, Fak, Fak1
Domain Architecture
Description	Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK).

CBL_MOUSE
NC score	0.057407 (rank : 717)	θ value	θ > 10 (rank : 593)
Query Neighborhood Hits	531	Target Neighborhood Hits	426	Shared Neighborhood Hits	92
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

UFO_HUMAN
NC score	0.057346 (rank : 718)	θ value	θ > 10 (rank : 1035)
Query Neighborhood Hits	531	Target Neighborhood Hits	981	Shared Neighborhood Hits	59
SwissProt Accessions	P30530	Gene names	AXL, UFO
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (AXL oncogene).

ALMS1_HUMAN
NC score	0.057317 (rank : 719)	θ value	θ > 10 (rank : 553)
Query Neighborhood Hits	531	Target Neighborhood Hits	356	Shared Neighborhood Hits	72
SwissProt Accessions	Q8TCU4, Q53S05, Q580Q8, Q86VP9, Q9Y4G4	Gene names	ALMS1, KIAA0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1.

ERBB3_HUMAN
NC score	0.057316 (rank : 720)	θ value	θ > 10 (rank : 687)
Query Neighborhood Hits	531	Target Neighborhood Hits	918	Shared Neighborhood Hits	44
SwissProt Accessions	P21860	Gene names	ERBB3, HER3
Domain Architecture
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Tyrosine kinase-type cell surface receptor HER3).

CT032_HUMAN
NC score	0.057298 (rank : 721)	θ value	θ > 10 (rank : 626)
Query Neighborhood Hits	531	Target Neighborhood Hits	235	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

ILK1_HUMAN
NC score	0.057275 (rank : 722)	θ value	θ > 10 (rank : 751)
Query Neighborhood Hits	531	Target Neighborhood Hits	857	Shared Neighborhood Hits	51
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
NC score	0.057237 (rank : 723)	θ value	θ > 10 (rank : 752)
Query Neighborhood Hits	531	Target Neighborhood Hits	848	Shared Neighborhood Hits	51
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

EPHA8_MOUSE
NC score	0.057226 (rank : 724)	θ value	θ > 10 (rank : 672)
Query Neighborhood Hits	531	Target Neighborhood Hits	969	Shared Neighborhood Hits	56
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

FXL19_MOUSE
NC score	0.057211 (rank : 725)	θ value	θ > 10 (rank : 718)
Query Neighborhood Hits	531	Target Neighborhood Hits	217	Shared Neighborhood Hits	71
SwissProt Accessions	Q6PB97, Q7TSH0, Q8BIB4	Gene names	Fbxl19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

EPHB2_HUMAN
NC score	0.057175 (rank : 726)	θ value	θ > 10 (rank : 675)
Query Neighborhood Hits	531	Target Neighborhood Hits	983	Shared Neighborhood Hits	53
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

CSF1R_HUMAN
NC score	0.057160 (rank : 727)	θ value	θ > 10 (rank : 620)
Query Neighborhood Hits	531	Target Neighborhood Hits	943	Shared Neighborhood Hits	46
SwissProt Accessions	P07333, Q6LDW5, Q6LDY4	Gene names	CSF1R, FMS
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

ES8L2_HUMAN
NC score	0.057148 (rank : 728)	θ value	θ > 10 (rank : 692)
Query Neighborhood Hits	531	Target Neighborhood Hits	193	Shared Neighborhood Hits	50
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

PF21B_MOUSE
NC score	0.057142 (rank : 729)	θ value	θ > 10 (rank : 870)
Query Neighborhood Hits	531	Target Neighborhood Hits	278	Shared Neighborhood Hits	73
SwissProt Accessions	Q8C966	Gene names	Phf21b
Domain Architecture	No domain graphic available
Description	PHD finger protein 21B.

UFO_MOUSE
NC score	0.057120 (rank : 730)	θ value	θ > 10 (rank : 1036)
Query Neighborhood Hits	531	Target Neighborhood Hits	988	Shared Neighborhood Hits	54
SwissProt Accessions	Q00993	Gene names	Axl, Ark, Ufo
Domain Architecture
Description	Tyrosine-protein kinase receptor UFO precursor (EC 2.7.10.1) (Adhesion-related kinase).

DDR2_HUMAN
NC score	0.057085 (rank : 731)	θ value	θ > 10 (rank : 637)
Query Neighborhood Hits	531	Target Neighborhood Hits	818	Shared Neighborhood Hits	45
SwissProt Accessions	Q16832	Gene names	DDR2, NTRKR3, TKT, TYRO10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

PGFRB_HUMAN
NC score	0.057074 (rank : 732)	θ value	θ > 10 (rank : 873)
Query Neighborhood Hits	531	Target Neighborhood Hits	962	Shared Neighborhood Hits	50
SwissProt Accessions	P09619, Q8N5L4	Gene names	PDGFRB
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PACN3_MOUSE
NC score	0.057054 (rank : 733)	θ value	θ > 10 (rank : 862)
Query Neighborhood Hits	531	Target Neighborhood Hits	380	Shared Neighborhood Hits	52
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PACN3_HUMAN
NC score	0.057037 (rank : 734)	θ value	θ > 10 (rank : 861)
Query Neighborhood Hits	531	Target Neighborhood Hits	385	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ERBB3_MOUSE
NC score	0.056985 (rank : 735)	θ value	θ > 10 (rank : 688)
Query Neighborhood Hits	531	Target Neighborhood Hits	898	Shared Neighborhood Hits	45
SwissProt Accessions	Q61526, Q3KQR1, Q68J64, Q810U8, Q8K317	Gene names	Erbb3
Domain Architecture	No domain graphic available
Description	Receptor tyrosine-protein kinase erbB-3 precursor (EC 2.7.10.1) (c- erbB3) (Glial growth factor receptor).

EPHB1_HUMAN
NC score	0.056985 (rank : 736)	θ value	θ > 10 (rank : 674)
Query Neighborhood Hits	531	Target Neighborhood Hits	988	Shared Neighborhood Hits	55
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

PGFRB_MOUSE
NC score	0.056971 (rank : 737)	θ value	θ > 10 (rank : 874)
Query Neighborhood Hits	531	Target Neighborhood Hits	960	Shared Neighborhood Hits	49
SwissProt Accessions	P05622	Gene names	Pdgfrb, Pdgfr
Domain Architecture
Description	Beta platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-beta) (CD140b antigen).

PLCD1_MOUSE
NC score	0.056965 (rank : 738)	θ value	θ > 10 (rank : 881)
Query Neighborhood Hits	531	Target Neighborhood Hits	106	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

ARMX2_MOUSE
NC score	0.056965 (rank : 739)	θ value	θ > 10 (rank : 569)
Query Neighborhood Hits	531	Target Neighborhood Hits	349	Shared Neighborhood Hits	93
SwissProt Accessions	Q6A058, Q9CXI9	Gene names	Armcx2, Kiaa0512
Domain Architecture	No domain graphic available
Description	Armadillo repeat-containing X-linked protein 2.

EPHA8_HUMAN
NC score	0.056932 (rank : 740)	θ value	θ > 10 (rank : 671)
Query Neighborhood Hits	531	Target Neighborhood Hits	956	Shared Neighborhood Hits	54
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHB2_MOUSE
NC score	0.056903 (rank : 741)	θ value	θ > 10 (rank : 676)
Query Neighborhood Hits	531	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

DDR2_MOUSE
NC score	0.056895 (rank : 742)	θ value	θ > 10 (rank : 638)
Query Neighborhood Hits	531	Target Neighborhood Hits	813	Shared Neighborhood Hits	45
SwissProt Accessions	Q62371	Gene names	Ddr2, Ntrkr3, Tkt, Tyro10
Domain Architecture
Description	Discoidin domain-containing receptor 2 precursor (EC 2.7.10.1) (Discoidin domain receptor 2) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO 10) (Neurotrophic tyrosine kinase, receptor-related 3) (CD167b antigen).

ANM2_MOUSE
NC score	0.056836 (rank : 743)	θ value	θ > 10 (rank : 556)
Query Neighborhood Hits	531	Target Neighborhood Hits	175	Shared Neighborhood Hits	44
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

VASP_MOUSE
NC score	0.056812 (rank : 744)	θ value	θ > 10 (rank : 1038)
Query Neighborhood Hits	531	Target Neighborhood Hits	195	Shared Neighborhood Hits	49
SwissProt Accessions	P70460, Q3TAP0, Q3TCD2, Q3U0C2, Q3UDF1, Q91VD2, Q9R214	Gene names	Vasp
Domain Architecture
Description	Vasodilator-stimulated phosphoprotein (VASP).

HGS_MOUSE
NC score	0.056763 (rank : 745)	θ value	θ > 10 (rank : 739)
Query Neighborhood Hits	531	Target Neighborhood Hits	589	Shared Neighborhood Hits	105
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

INSR_MOUSE
NC score	0.056693 (rank : 746)	θ value	θ > 10 (rank : 758)
Query Neighborhood Hits	531	Target Neighborhood Hits	968	Shared Neighborhood Hits	51
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

SF3B4_HUMAN
NC score	0.056690 (rank : 747)	θ value	1.38821 (rank : 306)
Query Neighborhood Hits	531	Target Neighborhood Hits	445	Shared Neighborhood Hits	73
SwissProt Accessions	Q15427	Gene names	SF3B4, SAP49
Domain Architecture
Description	Splicing factor 3B subunit 4 (Spliceosome-associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA-splicing factor SF3b 49 kDa subunit).

EPHA4_MOUSE
NC score	0.056613 (rank : 748)	θ value	θ > 10 (rank : 664)
Query Neighborhood Hits	531	Target Neighborhood Hits	982	Shared Neighborhood Hits	52
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

PGFRA_HUMAN
NC score	0.056592 (rank : 749)	θ value	θ > 10 (rank : 871)
Query Neighborhood Hits	531	Target Neighborhood Hits	980	Shared Neighborhood Hits	50
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PGFRA_MOUSE
NC score	0.056584 (rank : 750)	θ value	θ > 10 (rank : 872)
Query Neighborhood Hits	531	Target Neighborhood Hits	975	Shared Neighborhood Hits	48
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

EPHA4_HUMAN
NC score	0.056550 (rank : 751)	θ value	θ > 10 (rank : 663)
Query Neighborhood Hits	531	Target Neighborhood Hits	975	Shared Neighborhood Hits	51
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

CO5A2_HUMAN
NC score	0.056542 (rank : 752)	θ value	θ > 10 (rank : 614)
Query Neighborhood Hits	531	Target Neighborhood Hits	760	Shared Neighborhood Hits	124
SwissProt Accessions	P05997	Gene names	COL5A2
Domain Architecture
Description	Collagen alpha-2(V) chain precursor.

INSR_HUMAN
NC score	0.056533 (rank : 753)	θ value	θ > 10 (rank : 757)
Query Neighborhood Hits	531	Target Neighborhood Hits	963	Shared Neighborhood Hits	48
SwissProt Accessions	P06213	Gene names	INSR
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

RON_MOUSE
NC score	0.056490 (rank : 754)	θ value	θ > 10 (rank : 910)
Query Neighborhood Hits	531	Target Neighborhood Hits	836	Shared Neighborhood Hits	43
SwissProt Accessions	Q62190, Q62555	Gene names	Mst1r, Ron, Stk
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

BIN1_MOUSE
NC score	0.056267 (rank : 755)	θ value	2.36792 (rank : 338)
Query Neighborhood Hits	531	Target Neighborhood Hits	283	Shared Neighborhood Hits	56
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

RP1L1_HUMAN
NC score	0.056243 (rank : 756)	θ value	θ > 10 (rank : 916)
Query Neighborhood Hits	531	Target Neighborhood Hits	1072	Shared Neighborhood Hits	127
SwissProt Accessions	Q8IWN7, Q86SQ1, Q8IWN8, Q8IWN9, Q8IWP0, Q8IWP1, Q8IWP2	Gene names	RP1L1
Domain Architecture
Description	Retinitis pigmentosa 1-like 1 protein.

DIAP2_MOUSE
NC score	0.056235 (rank : 757)	θ value	θ > 10 (rank : 642)
Query Neighborhood Hits	531	Target Neighborhood Hits	260	Shared Neighborhood Hits	55
SwissProt Accessions	O70566, Q8C2G8	Gene names	Diaph2, Diap2
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) (mDia3).

ROR2_HUMAN
NC score	0.056224 (rank : 758)	θ value	θ > 10 (rank : 913)
Query Neighborhood Hits	531	Target Neighborhood Hits	1014	Shared Neighborhood Hits	47
SwissProt Accessions	Q01974, Q59GF5, Q5SPI5, Q9HAY7, Q9HB61	Gene names	ROR2, NTRKR2
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR2 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2).

EVL_MOUSE
NC score	0.056195 (rank : 759)	θ value	θ > 10 (rank : 697)
Query Neighborhood Hits	531	Target Neighborhood Hits	203	Shared Neighborhood Hits	56
SwissProt Accessions	P70429, Q9ERU8	Gene names	Evl
Domain Architecture
Description	Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein- like).

TYRO3_MOUSE
NC score	0.056060 (rank : 760)	θ value	θ > 10 (rank : 1034)
Query Neighborhood Hits	531	Target Neighborhood Hits	1007	Shared Neighborhood Hits	51
SwissProt Accessions	P55144, O09070, O09080, P70285, Q60752, Q62482, Q62483, Q62484, Q78E85, Q78E87	Gene names	Tyro3, Dtk, Rse
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase DTK) (TK19-2) (Etk2/tyro3).

EGFR_HUMAN
NC score	0.056032 (rank : 761)	θ value	θ > 10 (rank : 651)
Query Neighborhood Hits	531	Target Neighborhood Hits	939	Shared Neighborhood Hits	50
SwissProt Accessions	P00533, O00688, O00732, P06268, Q14225, Q92795, Q9BZS2, Q9GZX1, Q9H2C9, Q9H3C9, Q9UMD7, Q9UMD8, Q9UMG5	Gene names	EGFR, ERBB1
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1) (Receptor tyrosine-protein kinase ErbB-1).

FGFR4_MOUSE
NC score	0.055997 (rank : 762)	θ value	θ > 10 (rank : 711)
Query Neighborhood Hits	531	Target Neighborhood Hits	1026	Shared Neighborhood Hits	49
SwissProt Accessions	Q03142, Q5J7D9, Q8C3V5, Q8CIB8	Gene names	Fgfr4, Fgfr-4, Mpk-11
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) (CD334 antigen).

EPHA7_HUMAN
NC score	0.055929 (rank : 763)	θ value	θ > 10 (rank : 669)
Query Neighborhood Hits	531	Target Neighborhood Hits	1053	Shared Neighborhood Hits	53
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EGFR_MOUSE
NC score	0.055859 (rank : 764)	θ value	θ > 10 (rank : 652)
Query Neighborhood Hits	531	Target Neighborhood Hits	927	Shared Neighborhood Hits	49
SwissProt Accessions	Q01279	Gene names	Egfr
Domain Architecture
Description	Epidermal growth factor receptor precursor (EC 2.7.10.1).

EPHA7_MOUSE
NC score	0.055817 (rank : 765)	θ value	θ > 10 (rank : 670)
Query Neighborhood Hits	531	Target Neighborhood Hits	1025	Shared Neighborhood Hits	53
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

TYRO3_HUMAN
NC score	0.055805 (rank : 766)	θ value	θ > 10 (rank : 1033)
Query Neighborhood Hits	531	Target Neighborhood Hits	995	Shared Neighborhood Hits	49
SwissProt Accessions	Q06418, O14953, Q86VR3	Gene names	TYRO3, BYK, DTK, RSE, SKY
Domain Architecture
Description	Tyrosine-protein kinase receptor TYRO3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine- protein kinase DTK) (Protein-tyrosine kinase byk).

ROR1_MOUSE
NC score	0.055798 (rank : 767)	θ value	θ > 10 (rank : 912)
Query Neighborhood Hits	531	Target Neighborhood Hits	1025	Shared Neighborhood Hits	48
SwissProt Accessions	Q9Z139	Gene names	Ror1, Ntrkr1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1) (mROR1).

RON_HUMAN
NC score	0.055791 (rank : 768)	θ value	θ > 10 (rank : 909)
Query Neighborhood Hits	531	Target Neighborhood Hits	842	Shared Neighborhood Hits	44
SwissProt Accessions	Q04912	Gene names	MST1R, RON
Domain Architecture
Description	Macrophage-stimulating protein receptor precursor (EC 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage- stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain].

DGKK_HUMAN
NC score	0.055787 (rank : 769)	θ value	θ > 10 (rank : 639)
Query Neighborhood Hits	531	Target Neighborhood Hits	378	Shared Neighborhood Hits	73
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

MUSK_HUMAN
NC score	0.055716 (rank : 770)	θ value	θ > 10 (rank : 825)
Query Neighborhood Hits	531	Target Neighborhood Hits	1074	Shared Neighborhood Hits	48
SwissProt Accessions	O15146	Gene names	MUSK
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific tyrosine protein kinase receptor) (Muscle-specific kinase receptor) (MuSK).

APXL_HUMAN
NC score	0.055707 (rank : 771)	θ value	θ > 10 (rank : 562)
Query Neighborhood Hits	531	Target Neighborhood Hits	553	Shared Neighborhood Hits	79
SwissProt Accessions	Q13796	Gene names	APXL
Domain Architecture
Description	Apical-like protein (Protein APXL).

TB182_HUMAN
NC score	0.055631 (rank : 772)	θ value	θ > 10 (rank : 1007)
Query Neighborhood Hits	531	Target Neighborhood Hits	414	Shared Neighborhood Hits	68
SwissProt Accessions	Q9C0C2	Gene names	TNKS1BP1, KIAA1741, TAB182
Domain Architecture	No domain graphic available
Description	182 kDa tankyrase 1-binding protein.

MUSK_MOUSE
NC score	0.055560 (rank : 773)	θ value	θ > 10 (rank : 826)
Query Neighborhood Hits	531	Target Neighborhood Hits	1057	Shared Neighborhood Hits	47
SwissProt Accessions	Q61006, Q61005, Q61987, Q61988	Gene names	Musk, Nsk2
Domain Architecture	No domain graphic available
Description	Muscle, skeletal receptor tyrosine protein kinase precursor (EC 2.7.10.1) (Muscle-specific kinase receptor) (MuSK).

CSF1R_MOUSE
NC score	0.055560 (rank : 774)	θ value	θ > 10 (rank : 621)
Query Neighborhood Hits	531	Target Neighborhood Hits	983	Shared Neighborhood Hits	47
SwissProt Accessions	P09581, Q3U3P1, Q9DBH9	Gene names	Csf1r, Csfmr, Fms
Domain Architecture
Description	Macrophage colony-stimulating factor 1 receptor precursor (EC 2.7.10.1) (CSF-1-R) (Fms proto-oncogene) (c-fms) (CD115 antigen).

PER1_MOUSE
NC score	0.055545 (rank : 775)	θ value	0.279714 (rank : 199)
Query Neighborhood Hits	531	Target Neighborhood Hits	235	Shared Neighborhood Hits	54
SwissProt Accessions	O35973	Gene names	Per1, Per, Rigui
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (mPER) (M-Rigui).

TJAP1_HUMAN
NC score	0.055540 (rank : 776)	θ value	0.0330416 (rank : 110)
Query Neighborhood Hits	531	Target Neighborhood Hits	214	Shared Neighborhood Hits	15
SwissProt Accessions	Q5JTD0, Q5JTD1, Q5JWW1, Q68DB2, Q6P2P3, Q9H7V7	Gene names	TJAP1, PILT, TJP4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

CHIN_HUMAN
NC score	0.055531 (rank : 777)	θ value	θ > 10 (rank : 599)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	53
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RET_HUMAN
NC score	0.055520 (rank : 778)	θ value	θ > 10 (rank : 904)
Query Neighborhood Hits	531	Target Neighborhood Hits	873	Shared Neighborhood Hits	46
SwissProt Accessions	P07949, Q15250	Gene names	RET
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ROR1_HUMAN
NC score	0.055436 (rank : 779)	θ value	θ > 10 (rank : 911)
Query Neighborhood Hits	531	Target Neighborhood Hits	1018	Shared Neighborhood Hits	48
SwissProt Accessions	Q01973, Q92776	Gene names	ROR1, NTRKR1
Domain Architecture
Description	Tyrosine-protein kinase transmembrane receptor ROR1 precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 1).

WBS14_MOUSE
NC score	0.055385 (rank : 780)	θ value	θ > 10 (rank : 1054)
Query Neighborhood Hits	531	Target Neighborhood Hits	171	Shared Neighborhood Hits	47
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

IRS2_HUMAN
NC score	0.055336 (rank : 781)	θ value	3.0926 (rank : 373)
Query Neighborhood Hits	531	Target Neighborhood Hits	262	Shared Neighborhood Hits	68
SwissProt Accessions	Q9Y4H2, Q96RR2, Q9BZG0, Q9Y6I5	Gene names	IRS2
Domain Architecture
Description	Insulin receptor substrate 2 (IRS-2).

PTK7_HUMAN
NC score	0.055299 (rank : 782)	θ value	θ > 10 (rank : 896)
Query Neighborhood Hits	531	Target Neighborhood Hits	1103	Shared Neighborhood Hits	48
SwissProt Accessions	Q13308, Q13417	Gene names	PTK7, CCK4
Domain Architecture
Description	Tyrosine-protein kinase-like 7 precursor (Colon carcinoma kinase 4) (CCK-4).

NTRK2_HUMAN
NC score	0.055051 (rank : 783)	θ value	θ > 10 (rank : 845)
Query Neighborhood Hits	531	Target Neighborhood Hits	1081	Shared Neighborhood Hits	49
SwissProt Accessions	Q16620, Q16675, Q8WXJ6	Gene names	NTRK2, TRKB
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB) (Trk-B).

MAML1_MOUSE
NC score	0.054994 (rank : 784)	θ value	θ > 10 (rank : 799)
Query Neighborhood Hits	531	Target Neighborhood Hits	279	Shared Neighborhood Hits	67
SwissProt Accessions	Q6T264, Q505D8, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0	Gene names	Maml1, Kiaa0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

BCOR_HUMAN
NC score	0.054982 (rank : 785)	θ value	θ > 10 (rank : 582)
Query Neighborhood Hits	531	Target Neighborhood Hits	609	Shared Neighborhood Hits	91
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

INP5E_HUMAN
NC score	0.054977 (rank : 786)	θ value	θ > 10 (rank : 754)
Query Neighborhood Hits	531	Target Neighborhood Hits	201	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NRR6, Q15734	Gene names	INPP5E
Domain Architecture
Description	72 kDa inositol polyphosphate 5-phosphatase (EC 3.1.3.36) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (Phosphatidylinositol polyphosphate 5-phosphatase type IV).

NTRK2_MOUSE
NC score	0.054927 (rank : 787)	θ value	θ > 10 (rank : 846)
Query Neighborhood Hits	531	Target Neighborhood Hits	1088	Shared Neighborhood Hits	49
SwissProt Accessions	P15209, Q3TUF9, Q80WU0, Q91XJ9	Gene names	Ntrk2, Trkb
Domain Architecture
Description	BDNF/NT-3 growth factors receptor precursor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (GP145-TrkB/GP95-TrkB) (Trk-B).

RET_MOUSE
NC score	0.054927 (rank : 788)	θ value	θ > 10 (rank : 905)
Query Neighborhood Hits	531	Target Neighborhood Hits	884	Shared Neighborhood Hits	46
SwissProt Accessions	P35546, Q8BQ34, Q9QXH9	Gene names	Ret
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.10.1) (C-ret).

ES8L2_MOUSE
NC score	0.054855 (rank : 789)	θ value	θ > 10 (rank : 693)
Query Neighborhood Hits	531	Target Neighborhood Hits	169	Shared Neighborhood Hits	43
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FGFR4_HUMAN
NC score	0.054831 (rank : 790)	θ value	θ > 10 (rank : 710)
Query Neighborhood Hits	531	Target Neighborhood Hits	1037	Shared Neighborhood Hits	51
SwissProt Accessions	P22455, O43785, Q14309	Gene names	FGFR4, JTK2, TKF
Domain Architecture
Description	Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1) (FGFR-4) (CD334 antigen).

AL2S4_MOUSE
NC score	0.054785 (rank : 791)	θ value	θ > 10 (rank : 550)
Query Neighborhood Hits	531	Target Neighborhood Hits	193	Shared Neighborhood Hits	58
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

KIT_HUMAN
NC score	0.054769 (rank : 792)	θ value	θ > 10 (rank : 776)
Query Neighborhood Hits	531	Target Neighborhood Hits	953	Shared Neighborhood Hits	48
SwissProt Accessions	P10721, Q9UM99	Gene names	KIT
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

GON4L_HUMAN
NC score	0.054716 (rank : 793)	θ value	θ > 10 (rank : 722)
Query Neighborhood Hits	531	Target Neighborhood Hits	555	Shared Neighborhood Hits	94
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

MET_MOUSE
NC score	0.054684 (rank : 794)	θ value	θ > 10 (rank : 814)
Query Neighborhood Hits	531	Target Neighborhood Hits	844	Shared Neighborhood Hits	44
SwissProt Accessions	P16056, Q62125	Gene names	Met
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

AAK1_HUMAN
NC score	0.054672 (rank : 795)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	531	Target Neighborhood Hits	1077	Shared Neighborhood Hits	146
SwissProt Accessions	Q2M2I8, Q4ZFZ3, Q53RX6, Q9UPV4	Gene names	AAK1, KIAA1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

KSR2_HUMAN
NC score	0.054669 (rank : 796)	θ value	θ > 10 (rank : 779)
Query Neighborhood Hits	531	Target Neighborhood Hits	920	Shared Neighborhood Hits	84
SwissProt Accessions	Q6VAB6, Q8N775	Gene names	KSR2
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-2 (hKSR2).

MADCA_HUMAN
NC score	0.054542 (rank : 797)	θ value	θ > 10 (rank : 798)
Query Neighborhood Hits	531	Target Neighborhood Hits	221	Shared Neighborhood Hits	50
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

KIT_MOUSE
NC score	0.054465 (rank : 798)	θ value	θ > 10 (rank : 777)
Query Neighborhood Hits	531	Target Neighborhood Hits	949	Shared Neighborhood Hits	45
SwissProt Accessions	P05532, Q61415, Q61416, Q61417, Q6LEE9	Gene names	Kit, Sl
Domain Architecture
Description	Mast/stem cell growth factor receptor precursor (EC 2.7.10.1) (SCFR) (Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

CASL_HUMAN
NC score	0.054458 (rank : 799)	θ value	θ > 10 (rank : 591)
Query Neighborhood Hits	531	Target Neighborhood Hits	259	Shared Neighborhood Hits	62
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

EPHA3_HUMAN
NC score	0.054458 (rank : 800)	θ value	θ > 10 (rank : 661)
Query Neighborhood Hits	531	Target Neighborhood Hits	1005	Shared Neighborhood Hits	51
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

GAK3_HUMAN
NC score	0.054400 (rank : 801)	θ value	1.81305 (rank : 322)
Query Neighborhood Hits	531	Target Neighborhood Hits	182	Shared Neighborhood Hits	72
SwissProt Accessions	Q9YNA8	Gene names
Domain Architecture	No domain graphic available
Description	HERV-K_19q12 provirus ancestral Gag polyprotein (Gag polyprotein) (HERV-K(C19) Gag protein) [Contains: Matrix protein; Capsid protein; Nucleocapsid protein].

MET_HUMAN
NC score	0.054393 (rank : 802)	θ value	θ > 10 (rank : 813)
Query Neighborhood Hits	531	Target Neighborhood Hits	831	Shared Neighborhood Hits	43
SwissProt Accessions	P08581, O60366, Q12875, Q9UDX7, Q9UPL8	Gene names	MET
Domain Architecture
Description	Hepatocyte growth factor receptor precursor (EC 2.7.10.1) (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met).

DAAM2_MOUSE
NC score	0.054372 (rank : 803)	θ value	1.38821 (rank : 298)
Query Neighborhood Hits	531	Target Neighborhood Hits	371	Shared Neighborhood Hits	38
SwissProt Accessions	Q80U19, Q810J5	Gene names	Daam2, Kiaa0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

EPHA3_MOUSE
NC score	0.054326 (rank : 804)	θ value	θ > 10 (rank : 662)
Query Neighborhood Hits	531	Target Neighborhood Hits	1009	Shared Neighborhood Hits	51
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

TYK2_MOUSE
NC score	0.054312 (rank : 805)	θ value	θ > 10 (rank : 1032)
Query Neighborhood Hits	531	Target Neighborhood Hits	850	Shared Neighborhood Hits	49
SwissProt Accessions	Q9R117, O88431, Q8VE41	Gene names	Tyk2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

PKHA4_HUMAN
NC score	0.054189 (rank : 806)	θ value	4.03905 (rank : 414)
Query Neighborhood Hits	531	Target Neighborhood Hits	283	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

BRD8_MOUSE
NC score	0.054161 (rank : 807)	θ value	θ > 10 (rank : 586)
Query Neighborhood Hits	531	Target Neighborhood Hits	422	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R3B7, Q8C049, Q8R583, Q8VDP0	Gene names	Brd8
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 8.

SMAD5_MOUSE
NC score	0.054148 (rank : 808)	θ value	0.0148317 (rank : 85)
Query Neighborhood Hits	531	Target Neighborhood Hits	74	Shared Neighborhood Hits	19
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

MUCDL_MOUSE
NC score	0.054082 (rank : 809)	θ value	3.0926 (rank : 376)
Query Neighborhood Hits	531	Target Neighborhood Hits	461	Shared Neighborhood Hits	76
SwissProt Accessions	Q8VHF2, Q8CEJ3, Q9D8I9	Gene names	Mucdhl
Domain Architecture
Description	Mucin and cadherin-like protein precursor (Mu-protocadherin).

SETD8_MOUSE
NC score	0.053885 (rank : 810)	θ value	θ > 10 (rank : 927)
Query Neighborhood Hits	531	Target Neighborhood Hits	131	Shared Neighborhood Hits	31
SwissProt Accessions	Q2YDW7, Q8C0J9	Gene names	SETD8
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H4 lysine-20 specific (EC 2.1.1.43) (Histone H4-K20 methyltransferase) (H4-K20-HMTase) (SET domain-containing lysine methyltransferase 8) (SET domain-containing protein 8).

PDLI7_HUMAN
NC score	0.053783 (rank : 811)	θ value	θ > 10 (rank : 864)
Query Neighborhood Hits	531	Target Neighborhood Hits	547	Shared Neighborhood Hits	121
SwissProt Accessions	Q9NR12, Q14250, Q5XG82, Q6NVZ5, Q96C91, Q9BXB8, Q9BXB9	Gene names	PDLIM7, ENIGMA
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma).

TRI66_MOUSE
NC score	0.053775 (rank : 812)	θ value	θ > 10 (rank : 1026)
Query Neighborhood Hits	531	Target Neighborhood Hits	491	Shared Neighborhood Hits	97
SwissProt Accessions	Q924W6	Gene names	Trim66
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

NEBL_HUMAN
NC score	0.053744 (rank : 813)	θ value	θ > 10 (rank : 833)
Query Neighborhood Hits	531	Target Neighborhood Hits	457	Shared Neighborhood Hits	62
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

K1210_HUMAN
NC score	0.053696 (rank : 814)	θ value	θ > 10 (rank : 771)
Query Neighborhood Hits	531	Target Neighborhood Hits	219	Shared Neighborhood Hits	61
SwissProt Accessions	Q9ULL0, Q5JPN4	Gene names	KIAA1210
Domain Architecture	No domain graphic available
Description	Protein KIAA1210.

ZYX_HUMAN
NC score	0.053569 (rank : 815)	θ value	θ > 10 (rank : 1064)
Query Neighborhood Hits	531	Target Neighborhood Hits	387	Shared Neighborhood Hits	71
SwissProt Accessions	Q15942	Gene names	ZYX
Domain Architecture
Description	Zyxin (Zyxin-2).

ARHGF_HUMAN
NC score	0.053549 (rank : 816)	θ value	4.03905 (rank : 391)
Query Neighborhood Hits	531	Target Neighborhood Hits	214	Shared Neighborhood Hits	56
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

DYN1_HUMAN
NC score	0.053542 (rank : 817)	θ value	1.38821 (rank : 299)
Query Neighborhood Hits	531	Target Neighborhood Hits	216	Shared Neighborhood Hits	53
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

NCOR1_MOUSE
NC score	0.053471 (rank : 818)	θ value	5.27518 (rank : 443)
Query Neighborhood Hits	531	Target Neighborhood Hits	521	Shared Neighborhood Hits	71
SwissProt Accessions	Q60974, Q60812	Gene names	Ncor1, Rxrip13
Domain Architecture
Description	Nuclear receptor corepressor 1 (N-CoR1) (N-CoR) (Retinoid X receptor- interacting protein 13) (RIP13).

JAK1_MOUSE
NC score	0.053419 (rank : 819)	θ value	θ > 10 (rank : 766)
Query Neighborhood Hits	531	Target Neighborhood Hits	854	Shared Neighborhood Hits	48
SwissProt Accessions	P52332, Q62126	Gene names	Jak1
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

VGFR3_MOUSE
NC score	0.053288 (rank : 820)	θ value	θ > 10 (rank : 1049)
Query Neighborhood Hits	531	Target Neighborhood Hits	1056	Shared Neighborhood Hits	48
SwissProt Accessions	P35917	Gene names	Flt4, Flt-4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FGFR1_MOUSE
NC score	0.053200 (rank : 821)	θ value	θ > 10 (rank : 705)
Query Neighborhood Hits	531	Target Neighborhood Hits	1068	Shared Neighborhood Hits	50
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

SOS2_HUMAN
NC score	0.053132 (rank : 822)	θ value	0.0431538 (rank : 115)
Query Neighborhood Hits	531	Target Neighborhood Hits	193	Shared Neighborhood Hits	37
SwissProt Accessions	Q07890, Q15503	Gene names	SOS2
Domain Architecture
Description	Son of sevenless homolog 2 (SOS-2).

JAK1_HUMAN
NC score	0.053112 (rank : 823)	θ value	θ > 10 (rank : 765)
Query Neighborhood Hits	531	Target Neighborhood Hits	858	Shared Neighborhood Hits	48
SwissProt Accessions	P23458	Gene names	JAK1, JAK1A
Domain Architecture
Description	Tyrosine-protein kinase JAK1 (EC 2.7.10.2) (Janus kinase 1) (JAK-1).

FGFR1_HUMAN
NC score	0.053063 (rank : 824)	θ value	θ > 10 (rank : 704)
Query Neighborhood Hits	531	Target Neighborhood Hits	1069	Shared Neighborhood Hits	50
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

ZYX_MOUSE
NC score	0.053057 (rank : 825)	θ value	0.365318 (rank : 226)
Query Neighborhood Hits	531	Target Neighborhood Hits	347	Shared Neighborhood Hits	62
SwissProt Accessions	Q62523, P70461	Gene names	Zyx
Domain Architecture
Description	Zyxin.

VGFR2_HUMAN
NC score	0.052988 (rank : 826)	θ value	θ > 10 (rank : 1046)
Query Neighborhood Hits	531	Target Neighborhood Hits	1103	Shared Neighborhood Hits	52
SwissProt Accessions	P35968, O60723, Q14178	Gene names	KDR, FLK1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Kinase insert domain receptor) (Protein-tyrosine kinase receptor Flk-1) (CD309 antigen).

TAF3_HUMAN
NC score	0.052927 (rank : 827)	θ value	θ > 10 (rank : 1003)
Query Neighborhood Hits	531	Target Neighborhood Hits	568	Shared Neighborhood Hits	68
SwissProt Accessions	Q5VWG9, Q6GMS5, Q6P6B5, Q86VY6, Q9BQS9, Q9UFI8	Gene names	TAF3
Domain Architecture	No domain graphic available
Description	Transcription initiation factor TFIID subunit 3 (TBP-associated factor 3) (Transcription initiation factor TFIID 140 kDa subunit) (140 kDa TATA box-binding protein-associated factor) (TAF140) (TAFII140).

FGFR3_HUMAN
NC score	0.052881 (rank : 828)	θ value	θ > 10 (rank : 708)
Query Neighborhood Hits	531	Target Neighborhood Hits	1042	Shared Neighborhood Hits	48
SwissProt Accessions	P22607, Q14308, Q16294, Q16608	Gene names	FGFR3, JTK4
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (CD333 antigen).

TACC2_HUMAN
NC score	0.052856 (rank : 829)	θ value	θ > 10 (rank : 1002)
Query Neighborhood Hits	531	Target Neighborhood Hits	856	Shared Neighborhood Hits	109
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

PRRT3_MOUSE
NC score	0.052826 (rank : 830)	θ value	θ > 10 (rank : 893)
Query Neighborhood Hits	531	Target Neighborhood Hits	162	Shared Neighborhood Hits	32
SwissProt Accessions	Q6PE13	Gene names	Prrt3
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

FGFR2_MOUSE
NC score	0.052782 (rank : 831)	θ value	θ > 10 (rank : 707)
Query Neighborhood Hits	531	Target Neighborhood Hits	1062	Shared Neighborhood Hits	48
SwissProt Accessions	P21803, O55141, Q00389, Q61342	Gene names	Fgfr2, Bek, Ect1
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor) (CD332 antigen).

VGFR3_HUMAN
NC score	0.052754 (rank : 832)	θ value	θ > 10 (rank : 1048)
Query Neighborhood Hits	531	Target Neighborhood Hits	1037	Shared Neighborhood Hits	47
SwissProt Accessions	P35916	Gene names	FLT4
Domain Architecture
Description	Vascular endothelial growth factor receptor 3 precursor (EC 2.7.10.1) (VEGFR-3) (Tyrosine-protein kinase receptor FLT4).

FBX7_HUMAN
NC score	0.052708 (rank : 833)	θ value	0.47712 (rank : 231)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y3I1, Q5TGC4, Q96HM6, Q9UF21, Q9UKT2	Gene names	FBXO7, FBX7
Domain Architecture	No domain graphic available
Description	F-box only protein 7.

FGFR3_MOUSE
NC score	0.052659 (rank : 834)	θ value	θ > 10 (rank : 709)
Query Neighborhood Hits	531	Target Neighborhood Hits	1059	Shared Neighborhood Hits	48
SwissProt Accessions	Q61851, Q61564, Q63834	Gene names	Fgfr3, Mfr3, Sam3
Domain Architecture
Description	Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1) (FGFR-3) (Heparin-binding growth factor receptor) (CD333 antigen).

NUCKS_HUMAN
NC score	0.052645 (rank : 835)	θ value	θ > 10 (rank : 849)
Query Neighborhood Hits	531	Target Neighborhood Hits	143	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H1E3, Q9H1D6, Q9H723	Gene names	NUCKS1, NUCKS
Domain Architecture	No domain graphic available
Description	Nuclear ubiquitous casein and cyclin-dependent kinases substrate (P1).

FGFR2_HUMAN
NC score	0.052628 (rank : 836)	θ value	θ > 10 (rank : 706)
Query Neighborhood Hits	531	Target Neighborhood Hits	1062	Shared Neighborhood Hits	48
SwissProt Accessions	P21802, P18443, Q01742, Q12922, Q14300, Q14301, Q14302, Q14303, Q14304, Q14305, Q14672, Q14718, Q14719, Q86YI4, Q96KL9, Q96KM0, Q96KM1, Q96KM2, Q9NZU2, Q9NZU3, Q9UD01, Q9UD02, Q9UIH3, Q9UIH4, Q9UIH5, Q9UIH6, Q9UIH7, Q9UIH8, Q9UM87, Q9UMC6, Q9UNS7, Q9UQH7, Q9UQH8, Q9UQH9, Q9UQI0	Gene names	FGFR2, BEK, KSAM
Domain Architecture
Description	Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1) (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen).

APC_HUMAN
NC score	0.052619 (rank : 837)	θ value	θ > 10 (rank : 559)
Query Neighborhood Hits	531	Target Neighborhood Hits	603	Shared Neighborhood Hits	86
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

SH3G2_HUMAN
NC score	0.052523 (rank : 838)	θ value	θ > 10 (rank : 942)
Query Neighborhood Hits	531	Target Neighborhood Hits	324	Shared Neighborhood Hits	52
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

FGD1_HUMAN
NC score	0.052492 (rank : 839)	θ value	0.0736092 (rank : 129)
Query Neighborhood Hits	531	Target Neighborhood Hits	367	Shared Neighborhood Hits	78
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

TGON2_MOUSE
NC score	0.052461 (rank : 840)	θ value	θ > 10 (rank : 1016)
Query Neighborhood Hits	531	Target Neighborhood Hits	277	Shared Neighborhood Hits	61
SwissProt Accessions	Q62314	Gene names	Tgoln2, Ttgn2
Domain Architecture	No domain graphic available
Description	Trans-Golgi network integral membrane protein 2 precursor (TGN38B).

DIAP2_HUMAN
NC score	0.052424 (rank : 841)	θ value	θ > 10 (rank : 641)
Query Neighborhood Hits	531	Target Neighborhood Hits	342	Shared Neighborhood Hits	49
SwissProt Accessions	O60879, O60878, Q8WX06, Q8WX48, Q9UJL2	Gene names	DIAPH2, DIA
Domain Architecture
Description	Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2).

RUSC1_HUMAN
NC score	0.052385 (rank : 842)	θ value	θ > 10 (rank : 918)
Query Neighborhood Hits	531	Target Neighborhood Hits	226	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

CASL_MOUSE
NC score	0.052381 (rank : 843)	θ value	θ > 10 (rank : 592)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	52
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

TIE2_MOUSE
NC score	0.052365 (rank : 844)	θ value	θ > 10 (rank : 1020)
Query Neighborhood Hits	531	Target Neighborhood Hits	1204	Shared Neighborhood Hits	54
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

GUC2F_HUMAN
NC score	0.052243 (rank : 845)	θ value	θ > 10 (rank : 736)
Query Neighborhood Hits	531	Target Neighborhood Hits	740	Shared Neighborhood Hits	43
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

EMSY_HUMAN
NC score	0.052224 (rank : 846)	θ value	θ > 10 (rank : 654)
Query Neighborhood Hits	531	Target Neighborhood Hits	296	Shared Neighborhood Hits	58
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

VGFR2_MOUSE
NC score	0.052215 (rank : 847)	θ value	θ > 10 (rank : 1047)
Query Neighborhood Hits	531	Target Neighborhood Hits	1089	Shared Neighborhood Hits	50
SwissProt Accessions	P35918	Gene names	Kdr, Flk-1, Flk1
Domain Architecture
Description	Vascular endothelial growth factor receptor 2 precursor (EC 2.7.10.1) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (Kinase NYK) (CD309 antigen).

TIE1_HUMAN
NC score	0.052136 (rank : 848)	θ value	θ > 10 (rank : 1017)
Query Neighborhood Hits	531	Target Neighborhood Hits	1241	Shared Neighborhood Hits	55
SwissProt Accessions	P35590	Gene names	TIE1, TIE
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

WNK1_MOUSE
NC score	0.052110 (rank : 849)	θ value	θ > 10 (rank : 1056)
Query Neighborhood Hits	531	Target Neighborhood Hits	1179	Shared Neighborhood Hits	124
SwissProt Accessions	P83741	Gene names	Wnk1, Prkwnk1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1).

TIE1_MOUSE
NC score	0.052099 (rank : 850)	θ value	θ > 10 (rank : 1018)
Query Neighborhood Hits	531	Target Neighborhood Hits	1266	Shared Neighborhood Hits	54
SwissProt Accessions	Q06806, Q811F4	Gene names	Tie1, Tie, Tie-1
Domain Architecture
Description	Tyrosine-protein kinase receptor Tie-1 precursor (EC 2.7.10.1).

RBM16_HUMAN
NC score	0.052085 (rank : 851)	θ value	θ > 10 (rank : 902)
Query Neighborhood Hits	531	Target Neighborhood Hits	300	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UPN6, Q5TBU6, Q9BQN8, Q9BX43	Gene names	RBM16, KIAA1116
Domain Architecture
Description	Putative RNA-binding protein 16 (RNA-binding motif protein 16).

SH3G2_MOUSE
NC score	0.052069 (rank : 852)	θ value	θ > 10 (rank : 943)
Query Neighborhood Hits	531	Target Neighborhood Hits	319	Shared Neighborhood Hits	51
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

FIP1_HUMAN
NC score	0.051942 (rank : 853)	θ value	2.36792 (rank : 341)
Query Neighborhood Hits	531	Target Neighborhood Hits	118	Shared Neighborhood Hits	25
SwissProt Accessions	Q6UN15, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077	Gene names	FIP1L1, FIP1, RHE
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1) (Factor interacting with PAP) (hFip1) (Rearranged in hypereosinophilia).

TIE2_HUMAN
NC score	0.051892 (rank : 854)	θ value	θ > 10 (rank : 1019)
Query Neighborhood Hits	531	Target Neighborhood Hits	1192	Shared Neighborhood Hits	54
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

VGFR1_HUMAN
NC score	0.051871 (rank : 855)	θ value	θ > 10 (rank : 1044)
Query Neighborhood Hits	531	Target Neighborhood Hits	1109	Shared Neighborhood Hits	48
SwissProt Accessions	P17948, O60722, P16057, Q12954	Gene names	FLT1, FLT, FRT
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Vascular permeability factor receptor) (Tyrosine-protein kinase receptor FLT) (Flt-1) (Tyrosine-protein kinase FRT) (Fms-like tyrosine kinase 1).

ARAF_HUMAN
NC score	0.051763 (rank : 856)	θ value	θ > 10 (rank : 563)
Query Neighborhood Hits	531	Target Neighborhood Hits	924	Shared Neighborhood Hits	57
SwissProt Accessions	P10398, P07557, Q5H9B3	Gene names	ARAF, ARAF1, PKS, PKS2
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (A- raf-1) (Proto-oncogene Pks).

EPN3_HUMAN
NC score	0.051748 (rank : 857)	θ value	θ > 10 (rank : 683)
Query Neighborhood Hits	531	Target Neighborhood Hits	197	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H201, Q9BVN6, Q9NWK2	Gene names	EPN3
Domain Architecture
Description	Epsin-3 (EPS-15-interacting protein 3).

ES8L1_MOUSE
NC score	0.051721 (rank : 858)	θ value	θ > 10 (rank : 691)
Query Neighborhood Hits	531	Target Neighborhood Hits	143	Shared Neighborhood Hits	40
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

MYO15_MOUSE
NC score	0.051594 (rank : 859)	θ value	2.36792 (rank : 347)
Query Neighborhood Hits	531	Target Neighborhood Hits	467	Shared Neighborhood Hits	140
SwissProt Accessions	Q9QZZ4, O70395, Q9QWL6	Gene names	Myo15a, Myo15
Domain Architecture
Description	Myosin-15 (Myosin XV) (Unconventional myosin-15).

SF3A1_HUMAN
NC score	0.051445 (rank : 860)	θ value	θ > 10 (rank : 930)
Query Neighborhood Hits	531	Target Neighborhood Hits	199	Shared Neighborhood Hits	61
SwissProt Accessions	Q15459	Gene names	SF3A1, SAP114
Domain Architecture
Description	Splicing factor 3 subunit 1 (Spliceosome-associated protein 114) (SAP 114) (SF3a120).

MLTK_HUMAN
NC score	0.051374 (rank : 861)	θ value	θ > 10 (rank : 816)
Query Neighborhood Hits	531	Target Neighborhood Hits	911	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

DDEF1_MOUSE
NC score	0.051367 (rank : 862)	θ value	8.99809 (rank : 511)
Query Neighborhood Hits	531	Target Neighborhood Hits	592	Shared Neighborhood Hits	102
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

PRRT1_MOUSE
NC score	0.051307 (rank : 863)	θ value	θ > 10 (rank : 892)
Query Neighborhood Hits	531	Target Neighborhood Hits	102	Shared Neighborhood Hits	32
SwissProt Accessions	O35449	Gene names	Prrt1, Ng5
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 1.

CT174_HUMAN
NC score	0.051297 (rank : 864)	θ value	θ > 10 (rank : 627)
Query Neighborhood Hits	531	Target Neighborhood Hits	181	Shared Neighborhood Hits	56
SwissProt Accessions	Q5JPB2, Q5TDR4, Q8TCP0	Gene names	C20orf174
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf174.

CCD45_MOUSE
NC score	0.051220 (rank : 865)	θ value	1.38821 (rank : 295)
Query Neighborhood Hits	531	Target Neighborhood Hits	663	Shared Neighborhood Hits	72
SwissProt Accessions	Q8BVV7	Gene names	Ccdc45
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 45.

VGFR1_MOUSE
NC score	0.051219 (rank : 866)	θ value	θ > 10 (rank : 1045)
Query Neighborhood Hits	531	Target Neighborhood Hits	1118	Shared Neighborhood Hits	48
SwissProt Accessions	P35969, O55094, Q61517	Gene names	Flt1, Emrk2, Flt
Domain Architecture
Description	Vascular endothelial growth factor receptor 1 precursor (EC 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2).

RIN3_HUMAN
NC score	0.051172 (rank : 867)	θ value	θ > 10 (rank : 907)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

PPRB_MOUSE
NC score	0.051145 (rank : 868)	θ value	θ > 10 (rank : 884)
Query Neighborhood Hits	531	Target Neighborhood Hits	354	Shared Neighborhood Hits	82
SwissProt Accessions	Q925J9, O88323, Q3UHV0, Q6AXD5, Q8BW37, Q8BX19, Q8VDQ7, Q925K0	Gene names	Pparbp, Trip2
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor-binding protein (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TRIP-2).

GPTC8_HUMAN
NC score	0.051126 (rank : 869)	θ value	θ > 10 (rank : 725)
Query Neighborhood Hits	531	Target Neighborhood Hits	366	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

MEF2B_HUMAN
NC score	0.051064 (rank : 870)	θ value	θ > 10 (rank : 809)
Query Neighborhood Hits	531	Target Neighborhood Hits	150	Shared Neighborhood Hits	58
SwissProt Accessions	Q02080	Gene names	MEF2B, XMEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2B (Serum response factor-like protein 2) (XMEF2) (RSRFR2).

IQEC2_MOUSE
NC score	0.051006 (rank : 871)	θ value	3.0926 (rank : 372)
Query Neighborhood Hits	531	Target Neighborhood Hits	417	Shared Neighborhood Hits	88
SwissProt Accessions	Q5DU25	Gene names	Iqsec2, Kiaa0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

TYK2_HUMAN
NC score	0.050940 (rank : 872)	θ value	θ > 10 (rank : 1031)
Query Neighborhood Hits	531	Target Neighborhood Hits	841	Shared Neighborhood Hits	44
SwissProt Accessions	P29597, Q6QB10, Q96CH0	Gene names	TYK2
Domain Architecture
Description	Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2).

SH3G3_MOUSE
NC score	0.050918 (rank : 873)	θ value	θ > 10 (rank : 944)
Query Neighborhood Hits	531	Target Neighborhood Hits	236	Shared Neighborhood Hits	47
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

DAB2_HUMAN
NC score	0.050898 (rank : 874)	θ value	θ > 10 (rank : 629)
Query Neighborhood Hits	531	Target Neighborhood Hits	197	Shared Neighborhood Hits	58
SwissProt Accessions	P98082, Q13598, Q9BTY0, Q9UK04	Gene names	DAB2, DOC2
Domain Architecture
Description	Disabled homolog 2 (Differentially expressed protein 2) (DOC-2).

JAK3_HUMAN
NC score	0.050803 (rank : 875)	θ value	θ > 10 (rank : 767)
Query Neighborhood Hits	531	Target Neighborhood Hits	827	Shared Neighborhood Hits	44
SwissProt Accessions	P52333, Q13259, Q13260, Q13611, Q9Y6S2	Gene names	JAK3
Domain Architecture
Description	Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK).

PRGC2_MOUSE
NC score	0.050767 (rank : 876)	θ value	θ > 10 (rank : 887)
Query Neighborhood Hits	531	Target Neighborhood Hits	225	Shared Neighborhood Hits	50
SwissProt Accessions	Q8VHJ7, Q8C1C0	Gene names	Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta protein) (PGC-1beta) (ERR ligand 1) (PPARGC-1-beta) (PGC-1-beta).

ARAF_MOUSE
NC score	0.050674 (rank : 877)	θ value	θ > 10 (rank : 564)
Query Neighborhood Hits	531	Target Neighborhood Hits	874	Shared Neighborhood Hits	50
SwissProt Accessions	P04627, Q99J44, Q9CTT5, Q9D6R6, Q9DBU7	Gene names	Araf, A-raf, Araf1
Domain Architecture
Description	A-Raf proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1).

TTBK1_HUMAN
NC score	0.050660 (rank : 878)	θ value	θ > 10 (rank : 1027)
Query Neighborhood Hits	531	Target Neighborhood Hits	1058	Shared Neighborhood Hits	109
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

EHMT2_MOUSE
NC score	0.050567 (rank : 879)	θ value	θ > 10 (rank : 653)
Query Neighborhood Hits	531	Target Neighborhood Hits	750	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ANPRA_HUMAN
NC score	0.050518 (rank : 880)	θ value	θ > 10 (rank : 557)
Query Neighborhood Hits	531	Target Neighborhood Hits	612	Shared Neighborhood Hits	43
SwissProt Accessions	P16066, Q6P4Q3	Gene names	NPR1, ANPRA
Domain Architecture
Description	Atrial natriuretic peptide receptor A precursor (ANP-A) (ANPRA) (GC-A) (Guanylate cyclase) (EC 4.6.1.2) (NPR-A) (Atrial natriuretic peptide A-type receptor).

K0460_HUMAN
NC score	0.050469 (rank : 881)	θ value	6.88961 (rank : 477)
Query Neighborhood Hits	531	Target Neighborhood Hits	357	Shared Neighborhood Hits	56
SwissProt Accessions	Q5VT52, O75048, Q5VT53, Q6MZL4, Q86XD2	Gene names	KIAA0460
Domain Architecture	No domain graphic available
Description	Protein KIAA0460.

FIP1_MOUSE
NC score	0.050461 (rank : 882)	θ value	2.36792 (rank : 342)
Query Neighborhood Hits	531	Target Neighborhood Hits	120	Shared Neighborhood Hits	24
SwissProt Accessions	Q9D824, Q8BWX7, Q99LH0, Q9DBB2	Gene names	Fip1l1
Domain Architecture	No domain graphic available
Description	Pre-mRNA 3'-end-processing factor FIP1 (FIP1-like 1).

ZAN_HUMAN
NC score	0.050458 (rank : 883)	θ value	θ > 10 (rank : 1058)
Query Neighborhood Hits	531	Target Neighborhood Hits	679	Shared Neighborhood Hits	62
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

AKA12_HUMAN
NC score	0.050347 (rank : 884)	θ value	θ > 10 (rank : 549)
Query Neighborhood Hits	531	Target Neighborhood Hits	825	Shared Neighborhood Hits	84
SwissProt Accessions	Q02952, O00310, O00498, Q99970	Gene names	AKAP12, AKAP250
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 12 (A-kinase anchor protein 250 kDa) (AKAP 250) (Myasthenia gravis autoantigen gravin).

RIPK3_MOUSE
NC score	0.050337 (rank : 885)	θ value	θ > 10 (rank : 908)
Query Neighborhood Hits	531	Target Neighborhood Hits	867	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QZL0	Gene names	Ripk3, Rip3
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3).

MLTK_MOUSE
NC score	0.050249 (rank : 886)	θ value	θ > 10 (rank : 817)
Query Neighborhood Hits	531	Target Neighborhood Hits	874	Shared Neighborhood Hits	47
SwissProt Accessions	Q9ESL4, Q3V1X8, Q8BR73, Q9ESL3	Gene names	Mltk
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK).

RAF1_HUMAN
NC score	0.050181 (rank : 887)	θ value	θ > 10 (rank : 899)
Query Neighborhood Hits	531	Target Neighborhood Hits	886	Shared Neighborhood Hits	46
SwissProt Accessions	P04049	Gene names	RAF1, RAF
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

WNK1_HUMAN
NC score	0.050154 (rank : 888)	θ value	θ > 10 (rank : 1055)
Query Neighborhood Hits	531	Target Neighborhood Hits	1158	Shared Neighborhood Hits	120
SwissProt Accessions	Q9H4A3, O15052, Q86WL5, Q8N673, Q9P1S9	Gene names	WNK1, KDP, KIAA0344, PRKWNK1
Domain Architecture
Description	Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase with no lysine 1) (Protein kinase, lysine-deficient 1) (Kinase deficient protein).

KSR1_HUMAN
NC score	0.050128 (rank : 889)	θ value	θ > 10 (rank : 778)
Query Neighborhood Hits	531	Target Neighborhood Hits	867	Shared Neighborhood Hits	50
SwissProt Accessions	Q8IVT5, Q13476	Gene names	KSR1, KSR
Domain Architecture	No domain graphic available
Description	Kinase suppressor of ras-1 (Kinase suppressor of ras).

IRAK3_MOUSE
NC score	0.050071 (rank : 890)	θ value	θ > 10 (rank : 759)
Query Neighborhood Hits	531	Target Neighborhood Hits	628	Shared Neighborhood Hits	46
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

RAF1_MOUSE
NC score	0.050012 (rank : 891)	θ value	θ > 10 (rank : 900)
Query Neighborhood Hits	531	Target Neighborhood Hits	886	Shared Neighborhood Hits	48
SwissProt Accessions	Q99N57, Q91WH1	Gene names	Raf1, Craf
Domain Architecture
Description	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf).

CD2L7_HUMAN
NC score	0.049998 (rank : 892)	θ value	0.47712 (rank : 230)
Query Neighborhood Hits	531	Target Neighborhood Hits	1275	Shared Neighborhood Hits	148
SwissProt Accessions	Q9NYV4, O94978	Gene names	CRKRS, CRK7, KIAA0904
Domain Architecture
Description	Cell division cycle 2-related protein kinase 7 (EC 2.7.11.22) (CDC2- related protein kinase 7) (Cdc2-related kinase, arginine/serine-rich) (CrkRS).

FGD1_MOUSE
NC score	0.049972 (rank : 893)	θ value	0.279714 (rank : 193)
Query Neighborhood Hits	531	Target Neighborhood Hits	387	Shared Neighborhood Hits	70
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

EPN1_MOUSE
NC score	0.049422 (rank : 894)	θ value	8.99809 (rank : 514)
Query Neighborhood Hits	531	Target Neighborhood Hits	240	Shared Neighborhood Hits	74
SwissProt Accessions	Q80VP1, O70446	Gene names	Epn1
Domain Architecture
Description	Epsin-1 (EPS-15-interacting protein 1) (Intersectin-EH-binding protein 1) (Ibp1).

IQEC2_HUMAN
NC score	0.049337 (rank : 895)	θ value	3.0926 (rank : 371)
Query Neighborhood Hits	531	Target Neighborhood Hits	403	Shared Neighborhood Hits	87
SwissProt Accessions	Q5JU85, O60275	Gene names	IQSEC2, KIAA0522
Domain Architecture	No domain graphic available
Description	IQ motif and Sec7 domain-containing protein 2.

SMAD5_HUMAN
NC score	0.048796 (rank : 896)	θ value	0.0736092 (rank : 135)
Query Neighborhood Hits	531	Target Neighborhood Hits	57	Shared Neighborhood Hits	14
SwissProt Accessions	Q99717, O14688, Q15798, Q9UQA1	Gene names	SMAD5, MADH5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (hSmad5) (JV5-1).

TESK1_HUMAN
NC score	0.048684 (rank : 897)	θ value	0.125558 (rank : 156)
Query Neighborhood Hits	531	Target Neighborhood Hits	864	Shared Neighborhood Hits	58
SwissProt Accessions	Q15569	Gene names	TESK1
Domain Architecture
Description	Dual specificity testis-specific protein kinase 1 (EC 2.7.12.1) (Testicular protein kinase 1).

PCGF2_MOUSE
NC score	0.048432 (rank : 898)	θ value	0.125558 (rank : 154)
Query Neighborhood Hits	531	Target Neighborhood Hits	213	Shared Neighborhood Hits	20
SwissProt Accessions	P23798	Gene names	Pcgf2, Mel-18, Mel18, Rnf110, Zfp144, Znf144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) (Zfp-144).

T2FA_HUMAN
NC score	0.048209 (rank : 899)	θ value	6.88961 (rank : 494)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	28
SwissProt Accessions	P35269, Q9BWN0	Gene names	GTF2F1, RAP74
Domain Architecture
Description	Transcription initiation factor IIF alpha subunit (EC 2.7.11.1) (TFIIF-alpha) (Transcription initiation factor RAP74) (General transcription factor IIF polypeptide 1 74 kDa subunit protein).

WHRN_MOUSE
NC score	0.047639 (rank : 900)	θ value	0.62314 (rank : 257)
Query Neighborhood Hits	531	Target Neighborhood Hits	412	Shared Neighborhood Hits	74
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

PCGF2_HUMAN
NC score	0.047443 (rank : 901)	θ value	0.365318 (rank : 218)
Query Neighborhood Hits	531	Target Neighborhood Hits	222	Shared Neighborhood Hits	23
SwissProt Accessions	P35227	Gene names	PCGF2, MEL18, RNF110, ZNF144
Domain Architecture
Description	Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144).

SF3B2_HUMAN
NC score	0.047357 (rank : 902)	θ value	6.88961 (rank : 488)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q13435	Gene names	SF3B2, SAP145
Domain Architecture
Description	Splicing factor 3B subunit 2 (Spliceosome-associated protein 145) (SAP 145) (SF3b150) (Pre-mRNA-splicing factor SF3b 145 kDa subunit).

ELOA3_HUMAN
NC score	0.047309 (rank : 903)	θ value	4.03905 (rank : 397)
Query Neighborhood Hits	531	Target Neighborhood Hits	98	Shared Neighborhood Hits	29
SwissProt Accessions	Q8NG57	Gene names	TCEB3C, TCEB3L2
Domain Architecture
Description	RNA polymerase II transcription factor SIII subunit A3 (Elongin-A3) (EloA3) (Transcription elongation factor B polypeptide 3C).

NFH_HUMAN
NC score	0.047245 (rank : 904)	θ value	1.06291 (rank : 286)
Query Neighborhood Hits	531	Target Neighborhood Hits	1242	Shared Neighborhood Hits	111
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

PER1_HUMAN
NC score	0.047200 (rank : 905)	θ value	4.03905 (rank : 413)
Query Neighborhood Hits	531	Target Neighborhood Hits	215	Shared Neighborhood Hits	46
SwissProt Accessions	O15534	Gene names	PER1, KIAA0482, PER, RIGUI
Domain Architecture
Description	Period circadian protein 1 (Circadian pacemaker protein Rigui) (hPER).

K1949_MOUSE
NC score	0.047078 (rank : 906)	θ value	4.03905 (rank : 406)
Query Neighborhood Hits	531	Target Neighborhood Hits	134	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BQ30, Q3UDS6, Q8CEY9, Q8R3D8	Gene names
Domain Architecture	No domain graphic available
Description	Protein KIAA1949 homolog.

UB7I1_MOUSE
NC score	0.046937 (rank : 907)	θ value	5.27518 (rank : 459)
Query Neighborhood Hits	531	Target Neighborhood Hits	206	Shared Neighborhood Hits	50
SwissProt Accessions	P58283, Q3U493, Q3UE56, Q3UGM3, Q68FN0, Q6P1H8, Q6PWY5, Q8BN27, Q8C1U3	Gene names	Ubce7ip1, Triad3, Uip83, Zin
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (UbcM4-interacting protein 83) (Triad domain- containing protein 3).

PHF2_MOUSE
NC score	0.046341 (rank : 908)	θ value	0.21417 (rank : 180)
Query Neighborhood Hits	531	Target Neighborhood Hits	241	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTU0, Q80WA8	Gene names	Phf2
Domain Architecture
Description	PHD finger protein 2 (GRC5).

PHF2_HUMAN
NC score	0.045589 (rank : 909)	θ value	0.279714 (rank : 200)
Query Neighborhood Hits	531	Target Neighborhood Hits	208	Shared Neighborhood Hits	32
SwissProt Accessions	O75151, Q8N3K2, Q9Y6N4	Gene names	PHF2, KIAA0662
Domain Architecture
Description	PHD finger protein 2 (GRC5).

3BP1_MOUSE
NC score	0.045394 (rank : 910)	θ value	5.27518 (rank : 424)
Query Neighborhood Hits	531	Target Neighborhood Hits	238	Shared Neighborhood Hits	51
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RBM6_HUMAN
NC score	0.045333 (rank : 911)	θ value	0.813845 (rank : 269)
Query Neighborhood Hits	531	Target Neighborhood Hits	221	Shared Neighborhood Hits	24
SwissProt Accessions	P78332, O60549, O75524	Gene names	RBM6, DEF3
Domain Architecture
Description	RNA-binding protein 6 (RNA-binding motif protein 6) (RNA-binding protein DEF-3) (Lung cancer antigen NY-LU-12) (Protein G16).

AMELY_HUMAN
NC score	0.044992 (rank : 912)	θ value	6.88961 (rank : 463)
Query Neighborhood Hits	531	Target Neighborhood Hits	57	Shared Neighborhood Hits	21
SwissProt Accessions	Q99218, Q6RWT1	Gene names	AMELY, AMGL, AMGY
Domain Architecture
Description	Amelogenin, Y isoform precursor.

NU153_HUMAN
NC score	0.044955 (rank : 913)	θ value	6.88961 (rank : 482)
Query Neighborhood Hits	531	Target Neighborhood Hits	227	Shared Neighborhood Hits	46
SwissProt Accessions	P49790	Gene names	NUP153
Domain Architecture
Description	Nuclear pore complex protein Nup153 (Nucleoporin Nup153) (153 kDa nucleoporin).

MINK1_HUMAN
NC score	0.044112 (rank : 914)	θ value	2.36792 (rank : 346)
Query Neighborhood Hits	531	Target Neighborhood Hits	1477	Shared Neighborhood Hits	113
SwissProt Accessions	Q8N4C8, Q9P1X1, Q9P2R8	Gene names	MINK1, MAP4K6, MINK
Domain Architecture
Description	Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK).

WNK4_HUMAN
NC score	0.044104 (rank : 915)	θ value	2.36792 (rank : 359)
Query Neighborhood Hits	531	Target Neighborhood Hits	1043	Shared Neighborhood Hits	103
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

RBM15_HUMAN
NC score	0.043655 (rank : 916)	θ value	6.88961 (rank : 486)
Query Neighborhood Hits	531	Target Neighborhood Hits	309	Shared Neighborhood Hits	36
SwissProt Accessions	Q96T37, Q5D058, Q96PE4, Q96SC5, Q96SC6, Q96SC9, Q96SD0, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0	Gene names	RBM15, OTT
Domain Architecture
Description	Putative RNA-binding protein 15 (RNA-binding motif protein 15) (One- twenty two protein).

ERRFI_MOUSE
NC score	0.043631 (rank : 917)	θ value	4.03905 (rank : 399)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q99JZ7	Gene names	Errfi1, Mig6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein homolog) (Mig-6).

SYN3_HUMAN
NC score	0.043579 (rank : 918)	θ value	8.99809 (rank : 526)
Query Neighborhood Hits	531	Target Neighborhood Hits	203	Shared Neighborhood Hits	55
SwissProt Accessions	O14994	Gene names	SYN3
Domain Architecture
Description	Synapsin-3 (Synapsin III).

SMAD1_HUMAN
NC score	0.043430 (rank : 919)	θ value	4.03905 (rank : 418)
Query Neighborhood Hits	531	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	Q15797, Q16636	Gene names	SMAD1, BSP1, MADH1, MADR1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Transforming growth factor- beta signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

SMCA4_HUMAN
NC score	0.043413 (rank : 920)	θ value	1.38821 (rank : 308)
Query Neighborhood Hits	531	Target Neighborhood Hits	597	Shared Neighborhood Hits	96
SwissProt Accessions	P51532, O95052, Q9HBD3	Gene names	SMARCA4, BRG1, SNF2B, SNF2L4
Domain Architecture
Description	Probable global transcription activator SNF2L4 (EC 3.6.1.-) (ATP- dependent helicase SMARCA4) (SNF2-beta) (BRG-1 protein) (Mitotic growth and transcription activator) (Brahma protein homolog 1) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4).

STK39_MOUSE
NC score	0.043143 (rank : 921)	θ value	0.365318 (rank : 224)
Query Neighborhood Hits	531	Target Neighborhood Hits	915	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z1W9, Q80W13	Gene names	Stk39, Spak
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39).

PYR1_HUMAN
NC score	0.043103 (rank : 922)	θ value	1.06291 (rank : 289)
Query Neighborhood Hits	531	Target Neighborhood Hits	119	Shared Neighborhood Hits	28
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

FXL19_HUMAN
NC score	0.042532 (rank : 923)	θ value	0.62314 (rank : 242)
Query Neighborhood Hits	531	Target Neighborhood Hits	147	Shared Neighborhood Hits	25
SwissProt Accessions	Q6PCT2, Q8N789, Q9NT14	Gene names	FBXL19, FBL19
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19).

SN1L2_HUMAN
NC score	0.042318 (rank : 924)	θ value	3.0926 (rank : 383)
Query Neighborhood Hits	531	Target Neighborhood Hits	964	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H0K1, O94878, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8	Gene names	SNF1LK2, KIAA0781, QIK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Qin- induced kinase).

PROL1_HUMAN
NC score	0.042128 (rank : 925)	θ value	2.36792 (rank : 350)
Query Neighborhood Hits	531	Target Neighborhood Hits	7	Shared Neighborhood Hits	4
SwissProt Accessions	Q99935	Gene names	PROL1, BPLP
Domain Architecture	No domain graphic available
Description	Proline-rich protein 1 precursor (PRL1) (Basic proline-rich lacrimal protein).

ERRFI_HUMAN
NC score	0.041913 (rank : 926)	θ value	6.88961 (rank : 474)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UJM3, Q9NTG9, Q9UD05	Gene names	ERRFI1, MIG6
Domain Architecture	No domain graphic available
Description	ERBB receptor feedback inhibitor 1 (Mitogen-inducible gene 6 protein) (Mig-6).

STK39_HUMAN
NC score	0.041691 (rank : 927)	θ value	2.36792 (rank : 355)
Query Neighborhood Hits	531	Target Neighborhood Hits	882	Shared Neighborhood Hits	48
SwissProt Accessions	Q9UEW8, O14774, Q9UER4	Gene names	STK39, SPAK
Domain Architecture
Description	STE20/SPS1-related proline-alanine-rich protein kinase (EC 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT).

TNIK_HUMAN
NC score	0.041563 (rank : 928)	θ value	0.813845 (rank : 275)
Query Neighborhood Hits	531	Target Neighborhood Hits	1570	Shared Neighborhood Hits	103
SwissProt Accessions	Q9UKE5, O60298, Q8WUY7, Q9UKD8, Q9UKD9, Q9UKE0, Q9UKE1, Q9UKE2, Q9UKE3, Q9UKE4	Gene names	TNIK, KIAA0551
Domain Architecture
Description	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1).

FOG1_MOUSE
NC score	0.040974 (rank : 929)	θ value	1.06291 (rank : 281)
Query Neighborhood Hits	531	Target Neighborhood Hits	1237	Shared Neighborhood Hits	159
SwissProt Accessions	O35615	Gene names	Zfpm1, Fog, Fog1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

SN1L2_MOUSE
NC score	0.040933 (rank : 930)	θ value	3.0926 (rank : 384)
Query Neighborhood Hits	531	Target Neighborhood Hits	944	Shared Neighborhood Hits	79
SwissProt Accessions	Q8CFH6	Gene names	Snf1lk2, Sik2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SNF1-like kinase 2 (EC 2.7.11.1) (Salt-inducible kinase 2).

MYPN_MOUSE
NC score	0.040776 (rank : 931)	θ value	1.81305 (rank : 326)
Query Neighborhood Hits	531	Target Neighborhood Hits	421	Shared Neighborhood Hits	34
SwissProt Accessions	Q5DTJ9, Q7TPW5, Q8BZ76	Gene names	Mypn, Kiaa4170
Domain Architecture	No domain graphic available
Description	Myopalladin.

DYN2_HUMAN
NC score	0.040580 (rank : 932)	θ value	0.813845 (rank : 261)
Query Neighborhood Hits	531	Target Neighborhood Hits	112	Shared Neighborhood Hits	32
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

COHA1_HUMAN
NC score	0.040486 (rank : 933)	θ value	8.99809 (rank : 510)
Query Neighborhood Hits	531	Target Neighborhood Hits	400	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UMD9, Q02802, Q99018, Q9NQK9, Q9UC14	Gene names	COL17A1, BP180, BPAG2
Domain Architecture	No domain graphic available
Description	Collagen alpha-1(XVII) chain (Bullous pemphigoid antigen 2) (180 kDa bullous pemphigoid antigen 2).

HRG_HUMAN
NC score	0.039760 (rank : 934)	θ value	1.06291 (rank : 282)
Query Neighborhood Hits	531	Target Neighborhood Hits	43	Shared Neighborhood Hits	5
SwissProt Accessions	P04196	Gene names	HRG
Domain Architecture
Description	Histidine-rich glycoprotein precursor (Histidine-proline-rich glycoprotein) (HPRG).

ZCHC8_HUMAN
NC score	0.039625 (rank : 935)	θ value	1.38821 (rank : 313)
Query Neighborhood Hits	531	Target Neighborhood Hits	92	Shared Neighborhood Hits	16
SwissProt Accessions	Q6NZY4, Q7L2P6, Q8N2K5, Q96SK7, Q9NSS2, Q9NSS3	Gene names	ZCCHC8
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 8.

SMAD9_HUMAN
NC score	0.039390 (rank : 936)	θ value	1.81305 (rank : 331)
Query Neighborhood Hits	531	Target Neighborhood Hits	48	Shared Neighborhood Hits	10
SwissProt Accessions	O15198, O14989	Gene names	SMAD9, MADH6, MADH9
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Madh6).

PHF3_HUMAN
NC score	0.039100 (rank : 937)	θ value	5.27518 (rank : 447)
Query Neighborhood Hits	531	Target Neighborhood Hits	419	Shared Neighborhood Hits	47
SwissProt Accessions	Q92576, Q5T1T6, Q9NQ16, Q9UI45	Gene names	PHF3, KIAA0244
Domain Architecture
Description	PHD finger protein 3.

C2TA_HUMAN
NC score	0.038971 (rank : 938)	θ value	5.27518 (rank : 429)
Query Neighborhood Hits	531	Target Neighborhood Hits	190	Shared Neighborhood Hits	54
SwissProt Accessions	P33076	Gene names	CIITA, MHC2TA
Domain Architecture
Description	MHC class II transactivator (CIITA).

MYPN_HUMAN
NC score	0.038445 (rank : 939)	θ value	0.813845 (rank : 265)
Query Neighborhood Hits	531	Target Neighborhood Hits	418	Shared Neighborhood Hits	32
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

ZN516_MOUSE
NC score	0.038059 (rank : 940)	θ value	1.38821 (rank : 315)
Query Neighborhood Hits	531	Target Neighborhood Hits	1197	Shared Neighborhood Hits	160
SwissProt Accessions	Q7TSH3	Gene names	Znf516, Kiaa0222, Zfp516
Domain Architecture
Description	Zinc finger protein 516.

ZN703_HUMAN
NC score	0.038049 (rank : 941)	θ value	4.03905 (rank : 423)
Query Neighborhood Hits	531	Target Neighborhood Hits	154	Shared Neighborhood Hits	24
SwissProt Accessions	Q9H7S9, Q5XG76	Gene names	ZNF703
Domain Architecture	No domain graphic available
Description	Zinc finger protein 703.

SIN3A_HUMAN
NC score	0.037710 (rank : 942)	θ value	5.27518 (rank : 453)
Query Neighborhood Hits	531	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

DYN2_MOUSE
NC score	0.037684 (rank : 943)	θ value	0.62314 (rank : 241)
Query Neighborhood Hits	531	Target Neighborhood Hits	104	Shared Neighborhood Hits	23
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

CEP35_HUMAN
NC score	0.037567 (rank : 944)	θ value	1.81305 (rank : 318)
Query Neighborhood Hits	531	Target Neighborhood Hits	811	Shared Neighborhood Hits	64
SwissProt Accessions	Q5VT06, O75068, Q8TDK3, Q8WY20	Gene names	CEP350, CAP350, GM133
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein 350 (Centrosome-associated protein of 350 kDa).

BCOR_MOUSE
NC score	0.037522 (rank : 945)	θ value	5.27518 (rank : 428)
Query Neighborhood Hits	531	Target Neighborhood Hits	521	Shared Neighborhood Hits	63
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

TULP4_MOUSE
NC score	0.036786 (rank : 946)	θ value	5.27518 (rank : 457)
Query Neighborhood Hits	531	Target Neighborhood Hits	247	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JIL5, Q8CA75, Q922C2	Gene names	Tulp4, Tusp
Domain Architecture
Description	Tubby-like protein 4 (Tubby superfamily protein).

PRDM2_HUMAN
NC score	0.036746 (rank : 947)	θ value	0.0736092 (rank : 131)
Query Neighborhood Hits	531	Target Neighborhood Hits	1135	Shared Neighborhood Hits	108
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

INAR2_HUMAN
NC score	0.036104 (rank : 948)	θ value	0.62314 (rank : 244)
Query Neighborhood Hits	531	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	P48551	Gene names	IFNAR2, IFNARB
Domain Architecture
Description	Interferon-alpha/beta receptor beta chain precursor (IFN-alpha-REC) (Type I interferon receptor) (IFN-R) (Interferon alpha/beta receptor 2).

CCDC4_HUMAN
NC score	0.035574 (rank : 949)	θ value	5.27518 (rank : 431)
Query Neighborhood Hits	531	Target Neighborhood Hits	104	Shared Neighborhood Hits	18
SwissProt Accessions	Q6ZU67, Q58A26, Q58A27	Gene names	CCDC4
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 4.

CO5A1_HUMAN
NC score	0.034253 (rank : 950)	θ value	0.813845 (rank : 260)
Query Neighborhood Hits	531	Target Neighborhood Hits	434	Shared Neighborhood Hits	62
SwissProt Accessions	P20908, Q15094, Q5SUX4	Gene names	COL5A1
Domain Architecture
Description	Collagen alpha-1(V) chain precursor.

ANTOL_MOUSE
NC score	0.034125 (rank : 951)	θ value	2.36792 (rank : 334)
Query Neighborhood Hits	531	Target Neighborhood Hits	13	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D8N6	Gene names
Domain Architecture	No domain graphic available
Description	Antolefinin (Antolefinine).

US6NL_MOUSE
NC score	0.033955 (rank : 952)	θ value	6.88961 (rank : 496)
Query Neighborhood Hits	531	Target Neighborhood Hits	157	Shared Neighborhood Hits	39
SwissProt Accessions	Q80XC3, Q6ZQK8	Gene names	Usp6nl, Kiaa0019
Domain Architecture	No domain graphic available
Description	USP6 N-terminal-like protein.

ATBF1_MOUSE
NC score	0.033946 (rank : 953)	θ value	6.88961 (rank : 465)
Query Neighborhood Hits	531	Target Neighborhood Hits	1841	Shared Neighborhood Hits	154
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

PAK4_HUMAN
NC score	0.033712 (rank : 954)	θ value	6.88961 (rank : 484)
Query Neighborhood Hits	531	Target Neighborhood Hits	924	Shared Neighborhood Hits	65
SwissProt Accessions	O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8	Gene names	PAK4, KIAA1142
Domain Architecture
Description	Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4).

UBN1_HUMAN
NC score	0.033278 (rank : 955)	θ value	8.99809 (rank : 530)
Query Neighborhood Hits	531	Target Neighborhood Hits	170	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

JADE2_HUMAN
NC score	0.033108 (rank : 956)	θ value	1.81305 (rank : 325)
Query Neighborhood Hits	531	Target Neighborhood Hits	199	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NQC1, Q6IE80, Q8TEK0, Q92513, Q96GQ6	Gene names	PHF15, JADE2, KIAA0239
Domain Architecture
Description	Protein Jade-2 (PHD finger protein 15).

RILP_HUMAN
NC score	0.032298 (rank : 957)	θ value	3.0926 (rank : 378)
Query Neighborhood Hits	531	Target Neighborhood Hits	249	Shared Neighborhood Hits	18
SwissProt Accessions	Q96NA2, Q71RE6, Q9BSL3, Q9BYS3	Gene names	RILP
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

ANX11_HUMAN
NC score	0.032195 (rank : 958)	θ value	3.0926 (rank : 362)
Query Neighborhood Hits	531	Target Neighborhood Hits	192	Shared Neighborhood Hits	53
SwissProt Accessions	P50995	Gene names	ANXA11, ANX11
Domain Architecture
Description	Annexin A11 (Annexin XI) (Calcyclin-associated annexin 50) (CAP-50) (56 kDa autoantigen).

SCAP_HUMAN
NC score	0.032081 (rank : 959)	θ value	3.0926 (rank : 380)
Query Neighborhood Hits	531	Target Neighborhood Hits	368	Shared Neighborhood Hits	60
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

MNAB_HUMAN
NC score	0.032009 (rank : 960)	θ value	1.06291 (rank : 285)
Query Neighborhood Hits	531	Target Neighborhood Hits	196	Shared Neighborhood Hits	18
SwissProt Accessions	Q9HBD1, Q5JPD7, Q86ST6, Q8N3D6, Q96F27, Q9H5J2, Q9HBD2, Q9NWN9, Q9NXE1	Gene names	MNAB, RNF164
Domain Architecture	No domain graphic available
Description	Membrane-associated nucleic acid-binding protein (RING finger protein 164).

PAIRB_HUMAN
NC score	0.031988 (rank : 961)	θ value	6.88961 (rank : 483)
Query Neighborhood Hits	531	Target Neighborhood Hits	27	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NC51, Q8WUH0, Q96SE2, Q9BTY3, Q9BUM4, Q9Y367, Q9Y4S3	Gene names	SERBP1, PAIRBP1
Domain Architecture	No domain graphic available
Description	Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA- binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1).

SIN3A_MOUSE
NC score	0.031978 (rank : 962)	θ value	5.27518 (rank : 454)
Query Neighborhood Hits	531	Target Neighborhood Hits	169	Shared Neighborhood Hits	40
SwissProt Accessions	Q60520, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2	Gene names	Sin3a
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

CA106_HUMAN
NC score	0.030870 (rank : 963)	θ value	4.03905 (rank : 394)
Query Neighborhood Hits	531	Target Neighborhood Hits	124	Shared Neighborhood Hits	24
SwissProt Accessions	Q3KP66, Q9NV65, Q9NVI0	Gene names	C1orf106
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf106.

PGCA_HUMAN
NC score	0.030831 (rank : 964)	θ value	5.27518 (rank : 446)
Query Neighborhood Hits	531	Target Neighborhood Hits	821	Shared Neighborhood Hits	77
SwissProt Accessions	P16112, Q13650, Q9UCP4, Q9UCP5, Q9UDE0	Gene names	AGC1, CSPG1
Domain Architecture
Description	Aggrecan core protein precursor (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) [Contains: Aggrecan core protein 2].

HUWE1_MOUSE
NC score	0.030584 (rank : 965)	θ value	0.365318 (rank : 217)
Query Neighborhood Hits	531	Target Neighborhood Hits	406	Shared Neighborhood Hits	53
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

NFM_HUMAN
NC score	0.030134 (rank : 966)	θ value	1.06291 (rank : 287)
Query Neighborhood Hits	531	Target Neighborhood Hits	1328	Shared Neighborhood Hits	120
SwissProt Accessions	P07197	Gene names	NEF3, NEFM, NFM
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M) (Neurofilament 3).

PAIP1_HUMAN
NC score	0.029926 (rank : 967)	θ value	5.27518 (rank : 445)
Query Neighborhood Hits	531	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9H074, O60455, Q96B61, Q9BS63	Gene names	PAIP1
Domain Architecture
Description	Polyadenylate-binding protein-interacting protein 1 (Poly(A)-binding protein-interacting protein 1) (PABP-interacting protein 1) (PAIP-1).

MECP2_MOUSE
NC score	0.029859 (rank : 968)	θ value	4.03905 (rank : 409)
Query Neighborhood Hits	531	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z2D6	Gene names	Mecp2
Domain Architecture
Description	Methyl-CpG-binding protein 2 (MeCP-2 protein) (MeCP2).

GGA3_MOUSE
NC score	0.029825 (rank : 969)	θ value	1.81305 (rank : 324)
Query Neighborhood Hits	531	Target Neighborhood Hits	148	Shared Neighborhood Hits	25
SwissProt Accessions	Q8BMI3, Q80U71	Gene names	Gga3, Kiaa0154
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3).

SOX9_HUMAN
NC score	0.029822 (rank : 970)	θ value	4.03905 (rank : 421)
Query Neighborhood Hits	531	Target Neighborhood Hits	210	Shared Neighborhood Hits	47
SwissProt Accessions	P48436	Gene names	SOX9
Domain Architecture
Description	Transcription factor SOX-9.

NFAC2_HUMAN
NC score	0.029529 (rank : 971)	θ value	6.88961 (rank : 480)
Query Neighborhood Hits	531	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

CLCN1_HUMAN
NC score	0.029269 (rank : 972)	θ value	0.279714 (rank : 191)
Query Neighborhood Hits	531	Target Neighborhood Hits	89	Shared Neighborhood Hits	24
SwissProt Accessions	P35523	Gene names	CLCN1, CLC1
Domain Architecture
Description	Chloride channel protein, skeletal muscle (Chloride channel protein 1) (ClC-1).

TRIP6_HUMAN
NC score	0.029238 (rank : 973)	θ value	0.0961366 (rank : 146)
Query Neighborhood Hits	531	Target Neighborhood Hits	228	Shared Neighborhood Hits	25
SwissProt Accessions	Q15654, O15170, O15275, Q9BTB2, Q9UNT4	Gene names	TRIP6, OIP1
Domain Architecture
Description	Thyroid receptor-interacting protein 6 (TRIP6) (OPA-interacting protein 1) (Zyxin-related protein 1) (ZRP-1).

LR37B_HUMAN
NC score	0.029058 (rank : 974)	θ value	6.88961 (rank : 478)
Query Neighborhood Hits	531	Target Neighborhood Hits	392	Shared Neighborhood Hits	46
SwissProt Accessions	Q96QE4, Q5YKG6	Gene names	LRRC37B
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 37B precursor (C66 SLIT-like testicular protein).

XRCC1_HUMAN
NC score	0.028364 (rank : 975)	θ value	5.27518 (rank : 461)
Query Neighborhood Hits	531	Target Neighborhood Hits	131	Shared Neighborhood Hits	25
SwissProt Accessions	P18887, Q9HCB1	Gene names	XRCC1
Domain Architecture
Description	DNA-repair protein XRCC1 (X-ray repair cross-complementing protein 1).

UB7I1_HUMAN
NC score	0.027995 (rank : 976)	θ value	5.27518 (rank : 458)
Query Neighborhood Hits	531	Target Neighborhood Hits	177	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NWF9, Q6Y691, Q75ML7, Q7Z2H7, Q7Z7C1, Q8NHW7, Q9NYT1	Gene names	UBCE7IP1, ZIN
Domain Architecture	No domain graphic available
Description	E3 ubiquitin ligase TRIAD3 (EC 6.3.2.-) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B) (Triad domain-containing protein 3).

ANKS6_MOUSE
NC score	0.027982 (rank : 977)	θ value	5.27518 (rank : 427)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	37
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

PKN3_HUMAN
NC score	0.027980 (rank : 978)	θ value	2.36792 (rank : 349)
Query Neighborhood Hits	531	Target Neighborhood Hits	893	Shared Neighborhood Hits	52
SwissProt Accessions	Q6P5Z2, Q9UM03	Gene names	PKN3, PKNBETA
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN- beta) (Protein-kinase C-related kinase 3).

ANTOL_HUMAN
NC score	0.027839 (rank : 979)	θ value	6.88961 (rank : 464)
Query Neighborhood Hits	531	Target Neighborhood Hits	17	Shared Neighborhood Hits	6
SwissProt Accessions	Q96GY3, O14557, Q7Z2T9	Gene names	ames=MSTP064
Domain Architecture	No domain graphic available
Description	Antolefinin.

ETV6_HUMAN
NC score	0.027744 (rank : 980)	θ value	5.27518 (rank : 433)
Query Neighborhood Hits	531	Target Neighborhood Hits	120	Shared Neighborhood Hits	32
SwissProt Accessions	P41212, Q9UMF6	Gene names	ETV6, TEL, TEL1
Domain Architecture
Description	Transcription factor ETV6 (ETS-related protein Tel1) (Tel) (ETS translocation variant 6).

OXRP_HUMAN
NC score	0.027523 (rank : 981)	θ value	2.36792 (rank : 348)
Query Neighborhood Hits	531	Target Neighborhood Hits	544	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Y4L1	Gene names	HYOU1, ORP150
Domain Architecture
Description	150 kDa oxygen-regulated protein precursor (Orp150) (Hypoxia up- regulated 1).

WDR19_MOUSE
NC score	0.027448 (rank : 982)	θ value	2.36792 (rank : 358)
Query Neighborhood Hits	531	Target Neighborhood Hits	83	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UGF1, Q6ZPK8, Q80VQ6, Q8C794, Q8K3R5	Gene names	Wdr19, Kiaa1638
Domain Architecture	No domain graphic available
Description	WD repeat protein 19.

HXA3_MOUSE
NC score	0.027432 (rank : 983)	θ value	0.47712 (rank : 232)
Query Neighborhood Hits	531	Target Neighborhood Hits	558	Shared Neighborhood Hits	80
SwissProt Accessions	P02831, Q4V9Z8, Q61197	Gene names	Hoxa3, Hox-1.5, Hoxa-3
Domain Architecture
Description	Homeobox protein Hox-A3 (Hox-1.5) (MO-10).

WDR19_HUMAN
NC score	0.027410 (rank : 984)	θ value	2.36792 (rank : 357)
Query Neighborhood Hits	531	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NEZ3, Q8N5B4, Q9H5S0, Q9HCD4	Gene names	WDR19, KIAA1638
Domain Architecture	No domain graphic available
Description	WD repeat protein 19.

SAPS1_MOUSE
NC score	0.027313 (rank : 985)	θ value	5.27518 (rank : 449)
Query Neighborhood Hits	531	Target Neighborhood Hits	144	Shared Neighborhood Hits	38
SwissProt Accessions	Q7TSI3, Q80TJ4	Gene names	Saps1, Kiaa1115
Domain Architecture	No domain graphic available
Description	SAPS domain family member 1.

STAP2_MOUSE
NC score	0.027305 (rank : 986)	θ value	6.88961 (rank : 492)
Query Neighborhood Hits	531	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	Q8R0L1, Q8BWS2	Gene names	Stap2
Domain Architecture	No domain graphic available
Description	Signal-transducing adaptor protein 2 (STAP-2).

GGA1_MOUSE
NC score	0.027272 (rank : 987)	θ value	3.0926 (rank : 370)
Query Neighborhood Hits	531	Target Neighborhood Hits	128	Shared Neighborhood Hits	25
SwissProt Accessions	Q8R0H9, Q3U2N1	Gene names	Gga1
Domain Architecture	No domain graphic available
Description	ADP-ribosylation factor-binding protein GGA1 (Golgi-localized, gamma ear-containing, ARF-binding protein 1) (Gamma-adaptin-related protein 1).

PK1L1_HUMAN
NC score	0.027054 (rank : 988)	θ value	8.99809 (rank : 521)
Query Neighborhood Hits	531	Target Neighborhood Hits	140	Shared Neighborhood Hits	36
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

KCT2_HUMAN
NC score	0.026619 (rank : 989)	θ value	3.0926 (rank : 374)
Query Neighborhood Hits	531	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q8NC54, Q9NRG2	Gene names	KCT2, C5orf15
Domain Architecture	No domain graphic available
Description	Keratinocytes-associated transmembrane protein 2 precursor.

NFAC2_MOUSE
NC score	0.026276 (rank : 990)	θ value	4.03905 (rank : 411)
Query Neighborhood Hits	531	Target Neighborhood Hits	98	Shared Neighborhood Hits	22
SwissProt Accessions	Q60591, Q60984, Q60985	Gene names	Nfatc2, Nfat1, Nfatp
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

CI040_HUMAN
NC score	0.025384 (rank : 991)	θ value	4.03905 (rank : 395)
Query Neighborhood Hits	531	Target Neighborhood Hits	16	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IXQ3, Q9NWD3	Gene names	C9orf40
Domain Architecture	No domain graphic available
Description	Protein C9orf40.

UBP6_HUMAN
NC score	0.025261 (rank : 992)	θ value	1.06291 (rank : 291)
Query Neighborhood Hits	531	Target Neighborhood Hits	188	Shared Neighborhood Hits	30
SwissProt Accessions	P35125, Q15634, Q86WP6, Q8IWT4	Gene names	USP6, TRE2
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.1.2.15) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2).

ELL2_HUMAN
NC score	0.024889 (rank : 993)	θ value	2.36792 (rank : 340)
Query Neighborhood Hits	531	Target Neighborhood Hits	77	Shared Neighborhood Hits	13
SwissProt Accessions	O00472	Gene names	ELL2
Domain Architecture
Description	RNA polymerase II elongation factor ELL2.

INCE_HUMAN
NC score	0.024561 (rank : 994)	θ value	4.03905 (rank : 405)
Query Neighborhood Hits	531	Target Neighborhood Hits	978	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

RILP_MOUSE
NC score	0.024294 (rank : 995)	θ value	2.36792 (rank : 351)
Query Neighborhood Hits	531	Target Neighborhood Hits	257	Shared Neighborhood Hits	7
SwissProt Accessions	Q5ND29, Q80WB8, Q8CHY9	Gene names	Rilp
Domain Architecture	No domain graphic available
Description	Rab-interacting lysosomal protein.

ZAN_MOUSE
NC score	0.024202 (rank : 996)	θ value	2.36792 (rank : 360)
Query Neighborhood Hits	531	Target Neighborhood Hits	808	Shared Neighborhood Hits	40
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ATBF1_HUMAN
NC score	0.023911 (rank : 997)	θ value	8.99809 (rank : 502)
Query Neighborhood Hits	531	Target Neighborhood Hits	1547	Shared Neighborhood Hits	113
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

DPOLL_MOUSE
NC score	0.023872 (rank : 998)	θ value	3.0926 (rank : 367)
Query Neighborhood Hits	531	Target Neighborhood Hits	71	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QXE2, Q9CTJ1	Gene names	Poll, Polk
Domain Architecture
Description	DNA polymerase lambda (EC 2.7.7.7) (EC 4.2.99.-) (Pol Lambda) (DNA polymerase kappa).

FOXP4_MOUSE
NC score	0.023853 (rank : 999)	θ value	0.125558 (rank : 150)
Query Neighborhood Hits	531	Target Neighborhood Hits	211	Shared Neighborhood Hits	29
SwissProt Accessions	Q9DBY0, Q80V92, Q8CG10, Q8CIS1	Gene names	Foxp4
Domain Architecture	No domain graphic available
Description	Forkhead box protein P4 (Fork head-related protein like A) (mFKHLA).

SREC2_MOUSE
NC score	0.023741 (rank : 1000)	θ value	0.21417 (rank : 184)
Query Neighborhood Hits	531	Target Neighborhood Hits	605	Shared Neighborhood Hits	57
SwissProt Accessions	P59222	Gene names	Scarf2, Srec2
Domain Architecture	No domain graphic available
Description	Scavenger receptor class F member 2 precursor (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II).

UBP8_HUMAN
NC score	0.023191 (rank : 1001)	θ value	1.06291 (rank : 292)
Query Neighborhood Hits	531	Target Neighborhood Hits	751	Shared Neighborhood Hits	64
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

CABL2_MOUSE
NC score	0.022461 (rank : 1002)	θ value	8.99809 (rank : 505)
Query Neighborhood Hits	531	Target Neighborhood Hits	79	Shared Neighborhood Hits	18
SwissProt Accessions	Q8K3M5	Gene names	Cables2
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

CBLB_HUMAN
NC score	0.022445 (rank : 1003)	θ value	6.88961 (rank : 468)
Query Neighborhood Hits	531	Target Neighborhood Hits	261	Shared Neighborhood Hits	35
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

FOG1_HUMAN
NC score	0.022327 (rank : 1004)	θ value	4.03905 (rank : 400)
Query Neighborhood Hits	531	Target Neighborhood Hits	981	Shared Neighborhood Hits	81
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

NAT6_MOUSE
NC score	0.022191 (rank : 1005)	θ value	8.99809 (rank : 520)
Query Neighborhood Hits	531	Target Neighborhood Hits	36	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R123, Q8QZY5, Q8R014, Q9ERM0	Gene names	Nat6, Fus2
Domain Architecture
Description	N-acetyltransferase 6 (EC 2.3.1.-) (Fus-2 protein) (Fusion 2 protein).

HES7_MOUSE
NC score	0.020534 (rank : 1006)	θ value	5.27518 (rank : 440)
Query Neighborhood Hits	531	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BKT2, Q99JA6	Gene names	Hes7
Domain Architecture	No domain graphic available
Description	Transcription factor HES-7 (Hairy and enhancer of split 7) (bHLH factor Hes7).

TRAK2_HUMAN
NC score	0.020520 (rank : 1007)	θ value	0.813845 (rank : 276)
Query Neighborhood Hits	531	Target Neighborhood Hits	476	Shared Neighborhood Hits	14
SwissProt Accessions	O60296, Q8WVH7, Q96NS2, Q9C0K5, Q9C0K6	Gene names	TRAK2, ALS2CR3, KIAA0549
Domain Architecture
Description	Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein).

ROBO1_HUMAN
NC score	0.020367 (rank : 1008)	θ value	0.62314 (rank : 256)
Query Neighborhood Hits	531	Target Neighborhood Hits	529	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y6N7, Q7Z300, Q9BUS7	Gene names	ROBO1, DUTT1
Domain Architecture
Description	Roundabout homolog 1 precursor (H-Robo-1) (Deleted in U twenty twenty).

ZBP1_HUMAN
NC score	0.020034 (rank : 1009)	θ value	5.27518 (rank : 462)
Query Neighborhood Hits	531	Target Neighborhood Hits	43	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H171, Q5JY39, Q9BYW4	Gene names	ZBP1, C20orf183, DLM1
Domain Architecture
Description	Z-DNA-binding protein 1 (Tumor stroma and activated macrophage protein DLM-1).

LTBP4_MOUSE
NC score	0.019948 (rank : 1010)	θ value	0.21417 (rank : 179)
Query Neighborhood Hits	531	Target Neighborhood Hits	607	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

CI005_HUMAN
NC score	0.019875 (rank : 1011)	θ value	5.27518 (rank : 432)
Query Neighborhood Hits	531	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H330, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6	Gene names	C9orf5
Domain Architecture	No domain graphic available
Description	Protein C9orf5 (Protein CG-2).

SEC63_MOUSE
NC score	0.019845 (rank : 1012)	θ value	8.99809 (rank : 523)
Query Neighborhood Hits	531	Target Neighborhood Hits	601	Shared Neighborhood Hits	41
SwissProt Accessions	Q8VHE0, Q8VEB9	Gene names	Sec63, Sec63l
Domain Architecture
Description	Translocation protein SEC63 homolog.

SOX11_MOUSE
NC score	0.019806 (rank : 1013)	θ value	1.38821 (rank : 311)
Query Neighborhood Hits	531	Target Neighborhood Hits	96	Shared Neighborhood Hits	10
SwissProt Accessions	Q7M6Y2, O35178, O89036, Q04889, Q80XF0	Gene names	Sox11, Sox-11
Domain Architecture	No domain graphic available
Description	Transcription factor SOX-11.

ROBO3_HUMAN
NC score	0.019785 (rank : 1014)	θ value	6.88961 (rank : 487)
Query Neighborhood Hits	531	Target Neighborhood Hits	570	Shared Neighborhood Hits	41
SwissProt Accessions	Q96MS0	Gene names	ROBO3
Domain Architecture
Description	Roundabout homolog 3 precursor (Roundabout-like protein 3).

NAF1_HUMAN
NC score	0.019698 (rank : 1015)	θ value	4.03905 (rank : 410)
Query Neighborhood Hits	531	Target Neighborhood Hits	937	Shared Neighborhood Hits	53
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

SOX8_HUMAN
NC score	0.018781 (rank : 1016)	θ value	1.38821 (rank : 312)
Query Neighborhood Hits	531	Target Neighborhood Hits	100	Shared Neighborhood Hits	12
SwissProt Accessions	P57073, Q9NZW2	Gene names	SOX8
Domain Architecture
Description	Transcription factor SOX-8.

VINC_HUMAN
NC score	0.017836 (rank : 1017)	θ value	3.0926 (rank : 385)
Query Neighborhood Hits	531	Target Neighborhood Hits	145	Shared Neighborhood Hits	16
SwissProt Accessions	P18206, Q16450, Q5SWX2, Q7Z3B8, Q8IXU7	Gene names	VCL
Domain Architecture
Description	Vinculin (Metavinculin).

ADA19_HUMAN
NC score	0.017338 (rank : 1018)	θ value	0.62314 (rank : 235)
Query Neighborhood Hits	531	Target Neighborhood Hits	381	Shared Neighborhood Hits	61
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

CAC1A_MOUSE
NC score	0.017071 (rank : 1019)	θ value	3.0926 (rank : 364)
Query Neighborhood Hits	531	Target Neighborhood Hits	267	Shared Neighborhood Hits	49
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CSPG2_MOUSE
NC score	0.016982 (rank : 1020)	θ value	6.88961 (rank : 469)
Query Neighborhood Hits	531	Target Neighborhood Hits	711	Shared Neighborhood Hits	48
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

HS105_HUMAN
NC score	0.015837 (rank : 1021)	θ value	4.03905 (rank : 402)
Query Neighborhood Hits	531	Target Neighborhood Hits	209	Shared Neighborhood Hits	29
SwissProt Accessions	Q92598, O95739, Q5TBM6, Q5TBM8, Q9UPC4	Gene names	HSPH1, HSP105, HSP110, KIAA0201
Domain Architecture
Description	Heat-shock protein 105 kDa (Heat shock 110 kDa protein) (Antigen NY- CO-25).

TTLL5_HUMAN
NC score	0.015784 (rank : 1022)	θ value	8.99809 (rank : 529)
Query Neighborhood Hits	531	Target Neighborhood Hits	141	Shared Neighborhood Hits	28
SwissProt Accessions	Q6EMB2, Q9P1V5, Q9UPZ4	Gene names	TTLL5, KIAA0998, STAMP
Domain Architecture	No domain graphic available
Description	Tubulin--tyrosine ligase-like protein 5 (SRC1 and TIF2-associated modulatory protein).

TIAM1_MOUSE
NC score	0.015689 (rank : 1023)	θ value	5.27518 (rank : 456)
Query Neighborhood Hits	531	Target Neighborhood Hits	205	Shared Neighborhood Hits	18
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

B3A3_HUMAN
NC score	0.015645 (rank : 1024)	θ value	1.38821 (rank : 294)
Query Neighborhood Hits	531	Target Neighborhood Hits	119	Shared Neighborhood Hits	23
SwissProt Accessions	P48751	Gene names	SLC4A3, AE3
Domain Architecture
Description	Anion exchange protein 3 (Neuronal band 3-like protein) (Solute carrier family 4 member 3) (Cardiac/brain band 3-like protein) (CAE3/BAE3).

DDHD1_HUMAN
NC score	0.014528 (rank : 1025)	θ value	8.99809 (rank : 512)
Query Neighborhood Hits	531	Target Neighborhood Hits	40	Shared Neighborhood Hits	9
SwissProt Accessions	Q8NEL9, Q8WVH3, Q96LL2, Q9C0F8	Gene names	DDHD1, KIAA1705
Domain Architecture
Description	Probable phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1).

ZN217_HUMAN
NC score	0.014514 (rank : 1026)	θ value	8.99809 (rank : 531)
Query Neighborhood Hits	531	Target Neighborhood Hits	905	Shared Neighborhood Hits	90
SwissProt Accessions	O75362	Gene names	ZNF217, ZABC1
Domain Architecture	No domain graphic available
Description	Zinc finger protein 217.

PUM2_HUMAN
NC score	0.013026 (rank : 1027)	θ value	4.03905 (rank : 415)
Query Neighborhood Hits	531	Target Neighborhood Hits	67	Shared Neighborhood Hits	8
SwissProt Accessions	Q8TB72, O00234, Q53TV7, Q8WY43, Q9HAN2	Gene names	PUM2, KIAA0235, PUMH2
Domain Architecture
Description	Pumilio homolog 2 (Pumilio-2).

SP5_HUMAN
NC score	0.012985 (rank : 1028)	θ value	0.279714 (rank : 209)
Query Neighborhood Hits	531	Target Neighborhood Hits	832	Shared Neighborhood Hits	79
SwissProt Accessions	Q6BEB4	Gene names	SP5
Domain Architecture	No domain graphic available
Description	Transcription factor Sp5.

UBP34_HUMAN
NC score	0.012795 (rank : 1029)	θ value	5.27518 (rank : 460)
Query Neighborhood Hits	531	Target Neighborhood Hits	210	Shared Neighborhood Hits	19
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

TEAD2_HUMAN
NC score	0.012413 (rank : 1030)	θ value	4.03905 (rank : 422)
Query Neighborhood Hits	531	Target Neighborhood Hits	21	Shared Neighborhood Hits	7
SwissProt Accessions	Q15562, Q96IG3	Gene names	TEAD2, TEF4
Domain Architecture
Description	Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2).

CSPG3_MOUSE
NC score	0.012394 (rank : 1031)	θ value	6.88961 (rank : 470)
Query Neighborhood Hits	531	Target Neighborhood Hits	657	Shared Neighborhood Hits	51
SwissProt Accessions	P55066, Q6P1E3, Q8C4F8	Gene names	Cspg3, Ncan
Domain Architecture
Description	Neurocan core protein precursor (Chondroitin sulfate proteoglycan 3).

CAC1B_HUMAN
NC score	0.011754 (rank : 1032)	θ value	6.88961 (rank : 467)
Query Neighborhood Hits	531	Target Neighborhood Hits	257	Shared Neighborhood Hits	32
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

SP5_MOUSE
NC score	0.010939 (rank : 1033)	θ value	0.21417 (rank : 183)
Query Neighborhood Hits	531	Target Neighborhood Hits	821	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JHX2	Gene names	Sp5
Domain Architecture
Description	Transcription factor Sp5.

MICA1_MOUSE
NC score	0.010634 (rank : 1034)	θ value	8.99809 (rank : 519)
Query Neighborhood Hits	531	Target Neighborhood Hits	400	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

AP2A1_HUMAN
NC score	0.010272 (rank : 1035)	θ value	4.03905 (rank : 390)
Query Neighborhood Hits	531	Target Neighborhood Hits	56	Shared Neighborhood Hits	10
SwissProt Accessions	O95782, Q96CI7, Q96PP6, Q96PP7, Q9H070	Gene names	AP2A1, ADTAA
Domain Architecture
Description	AP-2 complex subunit alpha-1 (Adapter-related protein complex 2 alpha- 1 subunit) (Alpha-adaptin A) (Adaptor protein complex AP-2 alpha-1 subunit) (Clathrin assembly protein complex 2 alpha-A large chain) (100 kDa coated vesicle protein A) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit).

TEAD3_HUMAN
NC score	0.009708 (rank : 1036)	θ value	8.99809 (rank : 527)
Query Neighborhood Hits	531	Target Neighborhood Hits	22	Shared Neighborhood Hits	5
SwissProt Accessions	Q99594, O95910, Q8N6Y4	Gene names	TEAD3, TEF5
Domain Architecture
Description	Transcriptional enhancer factor TEF-5 (TEA domain family member 3) (TEAD-3) (DTEF-1).

FOXJ3_HUMAN
NC score	0.009201 (rank : 1037)	θ value	8.99809 (rank : 515)
Query Neighborhood Hits	531	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UPW0, Q9NSS7	Gene names	FOXJ3, KIAA1041
Domain Architecture
Description	Forkhead box protein J3.

LTBP2_HUMAN
NC score	0.009170 (rank : 1038)	θ value	2.36792 (rank : 345)
Query Neighborhood Hits	531	Target Neighborhood Hits	552	Shared Neighborhood Hits	32
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

ITCH_HUMAN
NC score	0.009096 (rank : 1039)	θ value	8.99809 (rank : 516)
Query Neighborhood Hits	531	Target Neighborhood Hits	162	Shared Neighborhood Hits	21
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

KMHN1_MOUSE
NC score	0.008512 (rank : 1040)	θ value	0.62314 (rank : 245)
Query Neighborhood Hits	531	Target Neighborhood Hits	949	Shared Neighborhood Hits	34
SwissProt Accessions	Q3V125, Q3TTQ8	Gene names	Gm172
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1 homolog.

ZHX3_MOUSE
NC score	0.008399 (rank : 1041)	θ value	6.88961 (rank : 499)
Query Neighborhood Hits	531	Target Neighborhood Hits	321	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0Q2, Q80U14	Gene names	Zhx3, Kiaa0395, Tix1
Domain Architecture
Description	Zinc finger and homeodomain protein 3 (Triple homeobox protein 1).

KCNN3_MOUSE
NC score	0.008222 (rank : 1042)	θ value	8.99809 (rank : 517)
Query Neighborhood Hits	531	Target Neighborhood Hits	171	Shared Neighborhood Hits	18
SwissProt Accessions	P58391	Gene names	Kcnn3, Sk3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3).

E2F2_HUMAN
NC score	0.008002 (rank : 1043)	θ value	8.99809 (rank : 513)
Query Neighborhood Hits	531	Target Neighborhood Hits	76	Shared Neighborhood Hits	13
SwissProt Accessions	Q14209	Gene names	E2F2
Domain Architecture
Description	Transcription factor E2F2 (E2F-2).

HXD3_MOUSE
NC score	0.007925 (rank : 1044)	θ value	4.03905 (rank : 403)
Query Neighborhood Hits	531	Target Neighborhood Hits	435	Shared Neighborhood Hits	34
SwissProt Accessions	P09027, Q3UUD3	Gene names	Hoxd3, Hox-4.1, Hoxd-3
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4.1) (Homeobox protein MH-19).

KLC4_HUMAN
NC score	0.007425 (rank : 1045)	θ value	5.27518 (rank : 441)
Query Neighborhood Hits	531	Target Neighborhood Hits	327	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NSK0	Gene names	KLC4, KNSL8
Domain Architecture
Description	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8).

CD6_HUMAN
NC score	0.007420 (rank : 1046)	θ value	8.99809 (rank : 507)
Query Neighborhood Hits	531	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	P30203, Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0	Gene names	CD6
Domain Architecture
Description	T-cell differentiation antigen CD6 precursor (T12) (TP120).

ANTR2_MOUSE
NC score	0.007204 (rank : 1047)	θ value	8.99809 (rank : 501)
Query Neighborhood Hits	531	Target Neighborhood Hits	26	Shared Neighborhood Hits	3
SwissProt Accessions	Q6DFX2, Q99L17	Gene names	Antxr2
Domain Architecture	No domain graphic available
Description	Anthrax toxin receptor 2 precursor.

PHLPP_MOUSE
NC score	0.006974 (rank : 1048)	θ value	5.27518 (rank : 448)
Query Neighborhood Hits	531	Target Neighborhood Hits	394	Shared Neighborhood Hits	23
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

ACRO_HUMAN
NC score	0.006809 (rank : 1049)	θ value	4.03905 (rank : 388)
Query Neighborhood Hits	531	Target Neighborhood Hits	291	Shared Neighborhood Hits	52
SwissProt Accessions	P10323, Q6ICK2	Gene names	ACR, ACRS
Domain Architecture
Description	Acrosin precursor (EC 3.4.21.10) [Contains: Acrosin light chain; Acrosin heavy chain].

SEM6C_HUMAN
NC score	0.005926 (rank : 1050)	θ value	4.03905 (rank : 417)
Query Neighborhood Hits	531	Target Neighborhood Hits	117	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H3T2, Q5JR71, Q8WXT8, Q8WXT9, Q8WXU0, Q96JF8	Gene names	SEMA6C, KIAA1869, SEMAY
Domain Architecture
Description	Semaphorin-6C precursor (Semaphorin Y) (Sema Y).

FZD8_MOUSE
NC score	0.005512 (rank : 1051)	θ value	2.36792 (rank : 343)
Query Neighborhood Hits	531	Target Neighborhood Hits	89	Shared Neighborhood Hits	7
SwissProt Accessions	Q61091	Gene names	Fzd8
Domain Architecture
Description	Frizzled-8 precursor (Fz-8) (mFz8).

DLX3_MOUSE
NC score	0.005066 (rank : 1052)	θ value	1.06291 (rank : 280)
Query Neighborhood Hits	531	Target Neighborhood Hits	367	Shared Neighborhood Hits	11
SwissProt Accessions	Q64205	Gene names	Dlx3
Domain Architecture
Description	Homeobox protein DLX-3.

ELK3_HUMAN
NC score	0.004641 (rank : 1053)	θ value	6.88961 (rank : 473)
Query Neighborhood Hits	531	Target Neighborhood Hits	64	Shared Neighborhood Hits	7
SwissProt Accessions	P41970, Q6FG57, Q6GU29, Q9UD17	Gene names	ELK3, NET, SAP2
Domain Architecture
Description	ETS domain-containing protein Elk-3 (ETS-related protein NET) (ETS- related protein ERP) (SRF accessory protein 2) (SAP-2).

CO8A_HUMAN
NC score	0.004312 (rank : 1054)	θ value	8.99809 (rank : 509)
Query Neighborhood Hits	531	Target Neighborhood Hits	200	Shared Neighborhood Hits	8
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

KIF9_HUMAN
NC score	0.002532 (rank : 1055)	θ value	4.03905 (rank : 407)
Query Neighborhood Hits	531	Target Neighborhood Hits	118	Shared Neighborhood Hits	5
SwissProt Accessions	Q9HAQ2, Q86Z28, Q9H8A4	Gene names	KIF9
Domain Architecture
Description	Kinesin-like protein KIF9.

GLIS1_HUMAN
NC score	0.002419 (rank : 1056)	θ value	0.279714 (rank : 194)
Query Neighborhood Hits	531	Target Neighborhood Hits	748	Shared Neighborhood Hits	36
SwissProt Accessions	Q8NBF1, Q8N9V9	Gene names	GLIS1
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLIS1 (GLI-similar 1).

LRP10_MOUSE
NC score	0.002333 (rank : 1057)	θ value	8.99809 (rank : 518)
Query Neighborhood Hits	531	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q7TQH7, Q7TS95, Q921T0, Q9EPE8	Gene names	Lrp10, Lrp9
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 10 precursor.

BC11A_MOUSE
NC score	0.002311 (rank : 1058)	θ value	4.03905 (rank : 393)
Query Neighborhood Hits	531	Target Neighborhood Hits	732	Shared Neighborhood Hits	27
SwissProt Accessions	Q9QYE3, Q80T89, Q8BLC7, Q8BLR4, Q8BWX3, Q921V4, Q9D0V2, Q9JIT4, Q9JLK8, Q9JLK9	Gene names	Bcl11a, Ctip1, Evi9, Kiaa1809
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A) (COUP-TF- interacting protein 1) (Ecotropic viral integration site 9 protein) (EVI-9).

ZIC5_HUMAN
NC score	0.002236 (rank : 1059)	θ value	0.813845 (rank : 277)
Query Neighborhood Hits	531	Target Neighborhood Hits	774	Shared Neighborhood Hits	48
SwissProt Accessions	Q96T25	Gene names	ZIC5
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5).

SLIK5_MOUSE
NC score	0.001952 (rank : 1060)	θ value	2.36792 (rank : 353)
Query Neighborhood Hits	531	Target Neighborhood Hits	301	Shared Neighborhood Hits	10
SwissProt Accessions	Q810B7, Q9CT21	Gene names	Slitrk5
Domain Architecture
Description	SLIT and NTRK-like protein 5 precursor.

BC11A_HUMAN
NC score	0.001583 (rank : 1061)	θ value	4.03905 (rank : 392)
Query Neighborhood Hits	531	Target Neighborhood Hits	745	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H165, Q86W14, Q8WU92, Q96JL6, Q9H163, Q9H164, Q9H3G9, Q9NWA7	Gene names	BCL11A, CTIP1, EVI9, KIAA1809
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11A (B-cell CLL/lymphoma 11A) (COUP-TF- interacting protein 1) (Ecotropic viral integration site 9 protein) (EVI-9).

ATS12_MOUSE
NC score	0.000300 (rank : 1062)	θ value	8.99809 (rank : 503)
Query Neighborhood Hits	531	Target Neighborhood Hits	220	Shared Neighborhood Hits	8
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ZN509_MOUSE
NC score	0.000261 (rank : 1063)	θ value	1.38821 (rank : 314)
Query Neighborhood Hits	531	Target Neighborhood Hits	990	Shared Neighborhood Hits	69
SwissProt Accessions	Q8BXX2, Q8CID4, Q8K2Z6	Gene names	Znf509, Zfp509
Domain Architecture	No domain graphic available
Description	Zinc finger protein 509.

EGR1_HUMAN
NC score	-0.001973 (rank : 1064)	θ value	6.88961 (rank : 472)
Query Neighborhood Hits	531	Target Neighborhood Hits	788	Shared Neighborhood Hits	31
SwissProt Accessions	P18146	Gene names	EGR1, ZNF225
Domain Architecture
Description	Early growth response protein 1 (EGR-1) (Krox-24 protein) (Transcription factor Zif268) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Zinc finger protein 225) (AT225).